Congenital muscular dystrophies (CMDs) are an extremely heterogenous group of neuromuscular diseases. The article presents the general information on clinical and pathogenetic aspects of CMD diagnosis with emphasis on one of the most common forms of nervous system disturbances — merosin-deficient congenital muscular dystrophy (CMD1A). The authors describe clinical pattern of CMD1A, pathogenesis, epidemiological data, approaches to instrumental, morphological and molecular genetic diagnosis, as well as symptomatic treatment and prenatal diagnosis in detail. As long as there are few genetically confirmed clinical cases of CMD1A described in the publications written in Russian, the authors present their 3-year-long follow-up of a child with genetically confirmed diagnosis of CMD1A (mutations c.2049_2050delAG and c.6993-2A > C of gene LAMA2 [compound heterozygous state]). The article presents a detailed discussion of the described case, comparison with results of recent foreign and Russian observational studies of CMD1A in children. It also contains information on differential diagnosis of CMD1A in the structure of other congenital myodystrophies and optimization of molecular genetic diagnosis.


Introduction: Breast implant infection is the most common complication after breast reconstruction surgeries. A lot of different implant infection management protocols exist, and they are still debatable which is the best. We present the case of a patient with breast implant infection after risk-reducing bilateral mastectomy with immediate direct-to-implant reconstruction. Case presentation: A 45-year-old woman underwent bilateral prophylactic mastectomy with immediate implant reconstruction. 31 days after the discharge she was administered to an emergency department with painful, erythematous non-healing wound in left breast. During the examination, a 2 cm wound covered with necrotic masses was observed. During the debridement surgery, a deeper implant-reaching necrosis was revealed. Immediate surgery involving debridement, lavage with antiseptics, defect closure was performed. A day after, the patient complained of left breast redness and enlargement. Despite no leukocytosis or elevated CRP, breast implant infection was diagnosed. Implant salvage procedure was indicated, during which partial capsulectomy and temporal explantation were performed, a swab for microbiological culture taken. The implant was irrigated with saline and povidone – iodine solution, then placed in a povidone – iodinebased solution with gentamicin (80.0 g) and cefazoline (1.0 g) 1.5 hours. After thorough debridement and implant pocket irrigation with 50 % povidone – iodine and antibiotic solution the same implant was reimplanted. Cefuroxime was administered and the drain was taken out after 5 days. 7 days after the surgery the patient was discharged without any signs of infection. Journal of Medical Sciences. May 25, 2020 Volume 8 | Issue 17. Electronic-ISSN: 2345-0592 206 Conclusions: Breast implant infection remains one of the most dreaded complications after breast reconstruction surgery. We could not find any publication about the reimplantation of the same implant during the implant salvage procedure. Our case shows that a new breast implant salvage protocol could be used successfully in order to salvage the infected breast implant.


Now a days use of nonlinear devices has been increased to a large extend. In the power system reforms some of the power supplying companies take into consideration the presence of harmonics as one of the parameter in the tariff. Therefore as we control the power factor within the limit using APFC panel, it is today's need to use appropriate filter to control the harmonics. This paper presents the study of harmonics present in an educational Institute and hardware design of passive filter. Readings are taken with and without filter to validate the developed hardware. The simulation work is also carried out in MATLAB to compare the results of Active and passive filter.


Interacting fluids, endowed with bulk viscous stresses, are discussed in a unified perspective with the aim of generalizing the treatment of cosmological perturbation theory to the case where both fluctuating decay rates and fluctuating bulk viscosity coefficients are simultaneously present in the relativistic plasma. A gauge-invariant treatment of the qualitatively new phenomena arising in this context is provided. In a complementary approach, faithful gauge-fixed descriptions of the gravitational and hydrodynamical fluctuations are developed and exploited. To deepen the interplay between bulk viscous stresses and fluctuating decay rates, illustrative examples are proposed and discussed both analytically and numerically. Particular attention is paid to the coupled evolution of curvature and entropy fluctuations when, in the relativistic plasma, at least one of the interacting fluids possesses a fluctuating bulk viscosity coefficient. It is argued that this class of models may be usefully employed as an effective description of the decay of the inflaton as well as of other phenomena involving imperfect relativistic fluids.


Abstract:In the late 1800s, Eduarda Mansilla de García worked to redefine women's place in Argentine society. While scholarship has praised the pioneering character of her literature for adults, little attention has been paid to the literature she wrote for children. This article analyzes how "La paloma blanca," a children's story published in the 1880 collection Cuentos, compromises the model of modern womanhood that Mansilla advances in her larger oeuvre. "La paloma blanca" tells the story of two cousins, one disabled and one exceptionally abled, who represent the two discourses of femininity that circulated in the late nineteenth century: the angelic "hunchback" metaphorizes how the discourse of domesticity paralyzes porteño women, and the athletic "tomboy" embodies the emancipatory possibilities of feminism. Because "La paloma blanca" mobilizes ableist stereotypes of disability in order to critique the patriarchal status quo, it ultimately implies that the patriarchy cannot be changed, and that women should maintain their traditional roles within the home. By challenging the feminist stance that Mansilla assumes in her literature for adults, "La paloma blanca" defies the expectation that nineteenth-century children's literature was low-quality, frivolous writing that served primarily to entertain. This article thus expands the study of gender and protest in nineteenth-century print culture to include literature written for younger audiences, and it also advances our understanding of Spanish American narratives of disability.


HIV Vaccines
A highly effective HIV vaccine has been the goal of vaccinologists for nearly 35 years. A successful vaccine would need to induce broadly neutralizing antibodies (bnAbs) that are capable of neutralizing multiple HIV strains (see the Perspective by Agazio and Torres). Steichen et al. report a strategy in which the first vaccine shot can lead to immune responses that generate desired bnAbs. By combining knowledge of human antibody repertoires and structure to guide design, they validated candidate immunogens through functional preclinical testing. Saunders et al. designed immunogens with differences in binding strength for bnAb precursors, which enabled selection of rare mutations after immunization. The immunogens promoted bnAb precursor maturation in humanized mice and macaques.

Science , this issue p. [eaax4380][1], p. [eaay7199][2]; see also p. [1197][3]

 [1]: /lookup/doi/10.1126/science.aax4380
 [2]: /lookup/doi/10.1126/science.aay7199
 [3]: /lookup/doi/10.1126/science.aaz8647


Before the Supreme Court's 2004 decision in Crawford v. Washington, Confrontation Clause jurisprudence was a muddled and unsettled area of constitutional law that often merged with evidentiary hearsay rules. In Crawford, however, the Court redefined the purpose of the Confrontation Clause by emphasizing the right of the defendant to test evidence against him in the "crucible of crossexamination." In a string of recent cases, the Court has continued on this trajectory, delineating the scope of its newly developed Confrontation Clause jurisprudence. In Williams v. Illinois, the Court will have the opportunity to do so again, this time by focusing on the admissibility of forensic evidence through expert testimony. Williams offers the Court yet another opportunity to apply the recently developed doctrine, to strengthen the essential right afforded by the Sixth Amendment, and to ensure the continued viability of the Crawford test.


The transformations that have taken place in the French école maternelle (nursery school) over the last 30 years may be characterised by a dual dynamic, internal and external, of scholarisation. Firstly, the analysis of its changing position with regard to primary school and within early childhood education and care shows a relative erasure of its specific nature and an increased dependency with regard to compulsory education. Secondly, an examination of the changes of its institutional curriculum and of the development of knowledge on school learning shows a growing focus on the mastering of language as it relates to the issues of educational success. This question of the influence of the école maternelle on children's future school career also contributes to its definition as part of the first cycle of formal education. International comparisons of pre-primary education serve to underline this process of scholarisation and also the continued diversity of social functions performed by the école maternelle.


By exploiting properties of the joint space mass-inertia matrix of flexure jointed hexapods, a decoupling method is proposed. The decoupling method, through a static input-output mapping, transforms the highly coupled 6 input 6 output dynamics into 6 independent single-input single-output (SISO) channels. Controls for these SISO channels are far simpler than their multiple-input multiple-output counterparts. Prior decoupling control algorithms imposed severe constraints on the allowable geometry, workspace, and payload. The paper derives a new algorithm which removes these constraints, thus greatly expanding the applications. Based on the new decoupling algorithm, an identification algorithm is introduced to identify the joint space mass-inertia matrix using payload accelerations and base forces. This algorithm can be used for precision payload calibration, this improving performance and removing the labor required to design the control for different payloads. The new decoupling algorithm is experimentally compared to earlier techniques. These experimental results indicate that the new approach is practical and improves performance.


Based on MSC Patran and MSC Nastran software, the finite element analysis technique of sub modeling and transferring coordinate system is adopted. The curving corner (sub model)in Z8A side frame A-area is analyzed, and the characteristic of load in curving corner of side frame A-area is obtained.


Blends of poly(vinyl alcohol) (PVA), poly(acrylic acid), (PAA), and poly(vinyl pyrrolidone) (PVP), with poly(N-isopropylacrylamide) (PNIPAM), were prepared by casting from aqueous solutions. Mechanical properties of PNIPAM/PVA blends were analyzed by stress–strain tests. Differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were employed to analyze the miscibility between the polymeric pairs. The results revealed that PNIPAM is not miscible with PVA and PVP in the whole range of composition. On the other hand, PNIPAM interacts strongly with PAA forming interpolymer complex due to the formation of cooperative hydrogen bonds. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 743–748, 2004


The cornea is a transparent tissue covering the front of the eye that refracts the light rays and therefore plays a great role in focusing ability of the eye (1). A slight change in the geometry of the cornea leads to a notable change in its focusing function. Therefore, the understanding of cornea mechanics is of utmost importance to better analyze the focusing ability of the eye.Copyright © 2013 by ASME


Tungstate and molybdate phosphors have received great attention for their excellent photoluminescent properties and thermal stabilities. In the article, Tb3+-activated tungstate and molybdate green phosphors were prepared by a solid-state reaction method at different caline temperatures and were compared and studied. The crystal structures and the morphologies of samples were characterized by X-ray diffraction (XRD) patterns and field emission scanning electron microscopy (FE-SEM) images. The energy-dispersive spectra (EDS) proved the compositions of the prepared samples. The photoluminescence (PL) spectra showed that the PL excitation spectra of Tb3+-doped Lu2W3O12 and Lu2Mo3O12 green phosphors consisted of a broad and strong charge transfer band (CTB) and 4f–5d transitions of Tb3+ in the ultraviolet (UV) wavelength range and some narrowed excitation peaks from the 4f–4f transition of Tb3+ in the near ultraviolet (NUV) wavelength region. The PL emission spectra of the phosphors exhibited the characteristic green emissions owing to the 5D4→7F5 transition of Tb3+ located at about 547 nm. The values of energy gap Eg were calculated based on the diffuse reflection spectra (DRS). The measuring temperature-dependent PL spectra illustrated the thermal stabilities of phosphors. The Tb3+-doped Lu2Mo3O12 phosphor presented normal thermal quenching phenomena and the values of the thermal activation energy Ea were calculated based on the measuring temperature dependent PL emission spectra. The Tb3+-doped Lu2W3O12 phosphor exhibited abnormal thermal enhancing CTB excitation intensity at about 170 °C. Furthermore, the PL decay curves suggested that the lifetime corresponding to the 5D4 level of Tb3+ in the Lu2W3O12 host lattice was longer than that in the Lu2Mo3O12 host lattice. Compared the Tb3+-doped Lu2Mo3O12 phosphor, the Tb3+-doped Lu2W3O12 phosphor has shown potential as an application in temperature sensors.


This study examines the momentum and contrarian effects on stock returns in one of the leading emerging markets, which has a unique market structure, with record-high inflation, high volatility, high turnover, low correlation of returns with other exchanges and myopic investors: the Istanbul Stock Exchange (ISE). It also investigates the weak-form efficiency of the stock market by examining the profitability of a number of contrarian strategies based on past returns, size, price, book-to-market and earnings-to-price ratios of stocks in various lengths of formation and holding periods. Our findings show that a self-financing trading strategy, buying past loser stocks and selling past winner stocks generate significant abnormal returns (approximately 15% annually) in ISE. However, these large contrarian profits are for bearing the extra risk of loser stocks similar to the US results. We also find significant price, size, and B/M effects in stock returns. Finally, our results show the continous profitability of contrarian strategies both in very short (starting from 1 month) and in long holding periods (up to 36 months), which appears to be related to country-specific factors. Copyright (c) International Review of Finance Ltd. 2007.


We have developed a method to design a lateral band-gap modulation in a quantum well heterostructure. The lateral strain variation is induced by patterning of a stressor layer grown on top of a single quantum well which itself is not patterned. The three-dimensional (3D) strain distribution within the lateral nanostructure is calculated using linear elasticity theory applying a finite element technique. Based on the deformation potential approach the calculated strain distribution is translated into a local variation of the band-gap energy. Using a given vertical layer structure we are able to optimize the geometrical parameters to provide a nanostructure with maximum lateral band-gap variation. Experimentally such a structure was realized by etching a surface grating into a tensile-strained InGaP stressor layer grown on top of a compressively strained InGaAs-single quantum well. The achieved 3D strain distribution and the induced band-gap variation are successfully probed by x-ray grazing incidence diffraction and low-temperature photoluminescence measurements, respectively.


The method for studying semileptonic neutral kaon decays at CPLEAR is presented together with a preliminary data analysis. For the first time a direct determination of T violation is shown to be possible and low statistics results are given. From the same data the K{,-K,y mass difference, Am, the CP violation parameter of KS, ES, and the parameter I testing the AS = AQ rule are also obtained.


PurposeWith a growing number of older workers in the labor force, cultivating an age-friendly working environment becomes increasingly important. Inspired by the job demands–resources (JD-R) model, this study aims to investigate whether the negative effects of perceived age discrimination (PAD) on work-related outcomes would be explained by job resources and demands.Design/methodology/approachA total of 333 Hong Kong Chinese employees aged 40 and above (M = 46.62, SD = 6.21; 60% female) completed an online survey that covered measures on workplace age discrimination, job resources and demands, work engagement, intention to stay and work strain.FindingsPAD at work was associated with reduced job resources and increased job demands. The results of the mediation analyses showed support from supervisor and coworkers could account for the effects of PAD on work engagement and intention to stay, whereas emotional demand or workload could explain the effects of PAD on work engagement and work strain.Practical implicationsThe findings of this research unveil the underlying mechanisms between age discrimination and work-related outcomes through job resources and job demands. Cultivating a supportive organizational climate toward older employees and offering awareness-based training programs are necessary to mitigate age biases in the workplace.Originality/valueBuilding on the JD-R model, this study revealed the possible mechanism underlying the negative effects of PAD. Perceptions of age discrimination decrease older workers' job resources and increase their job demands, subsequently lower their work engagement and intention to stay and increase their work strain.


Abiding in silence... Breathing in... I am aware of breathing in...Breathing out...I am aware of breathing out. Distractions arise... hearing...hearing...breathing in...breathing out...The judging mind arises,.."I can't do this...this is boring... uncomfortable" judging...judging... Back to the breath.... breathing in...breathing out ...the feel of the breath flowing in and out of the body...The body relaxes a bit, the mind settles ever so slightly and there are several moments of going on being...perhaps longer... Then body sensations or thoughts come to the forefront once more...gently noticing...welcoming... labeling ... accepting ... holding ...breathing in...breathing out. And so the back and forth dance of ego and self occurs in just five minutes of mindfulness practice.


A partial diallel crossing of Rhode Island Red (RIR), White Leghorn (WLH), Fayoumi (FO), Desi normal (DN) and Desi dwarf (DD) produced RIR, WLH, FO, DN, DD, RIR x DD, WLH x DD and FO x DD offspring. A total 709 chicks, 75 RIR, 130 WLH, 100 FO, 70 DN, 66 DD, 80 RIR x DD, 80 WLH x DD and 108 FO x DD were reared for studying growth performance up to 18 weeks of age. At 19 weeks, the crossbreds RIR x DD, WLH x DD and FO x DD were separated into normal and dwarf genetic groups on the basis of shank length and thus 11 genetic groups, RIR, WLH, FO, DN, DD, RIR x DD normal, RIR x DD dwarf, WLH x DD normal, WLH x DD dwarf, FO x DD normal and FO x DD dwarf were obtained. Day-old weight differed significantly (P 0.05). The shank length differed significantly between genotypes at all ages regardless of sex (P<0.01) and differences between genotypes increased at older ages. Shank length of pure breeds and normal crossbreds were similar and much longer than in dwarf crossbreds DOI: http://dx.doi.org/10.3329/bvet.v30i1.16282 Bangl. vet . 2013. Vol. 30, No. 1, 25-32


The peculiarities of electrical capacitance tomography sensors largely determine the performance of tomography system. The sensors structure parameters have a strong impact on the capacitance sensitivity distribution, further influence the quality of reconstruction image. This paper using finite element simulation analysis formulizes the influence of sensor structure on sensitivity distribution, and presents a method for improving sensitivity.


The interplay between cancerous cells and immune cells has always been an intriguing topic in medicine and biology. Cancer cells emerge from self-cells through a series of genetic mutations. They often retain self-cells' capacity in being exempt from immune surveillance. Therefore, bringing cancer cells back under the radar of immune system has long been considered as a necessary step toward complete tumor eradication and long-term antitumor protection. Based on this rationale, a series of immunotherapies were designed and many have shown promising results. Some have gone through multiple stages of clinical trials. As a result, a successful immunotherapy is an intricate clinical procedure that affects the function of a myriad of cells. Only comprehensive studies that profile multiple aspects (e.g., cellular abundance, phenotypes, and functions) over time at the finest details can effectively monitor the convoluted immune response induced by therapy. Many recent technical developments aim to provide a solution for comprehensive clinical immune assessment.


An analysis of the wool productivity in Caucasian breed sheep of various sex and age groups is presented, and the effectiveness of selection in terms of the length, fineness, thickness and yolk of wool is shown. It was revealed that in the CJSC of "Plemzavod named after V.V. Kalyagin, the Hero of Socialist Labor", the average clip of greasy wool is 5.8 kg when the yield of washed fiber is 59.1%. It has been established that the genetic recourses of the herd enable the farm to receive an average clip of 3.4 kg of washed wool. The selection differential for washed wool clip in animals of different sex and age groups was determined, which has made 0.9-3.3 kg, or 28.8-63.5%. The sheep capita of the Caucasian breed in the breeding plant is characterized by very thick wool (95.7%), which is confirmed by experimental data, where the total thickness of the hair follicles is 59.1 pieces per 1 mm2 of skin. It was established that the selection differential by the length of wool in the context of sex and age groups varies within 1.5-3.5 cm, or 16.7-43.8%. The revealed differentiation of wool fineness in Caucasian breed sheep confirms the consolidation of the herd by this trait, where the 64th quality is the leading fineness. It was experimentally established that the amount of wool fat in greasy non-fatted wool is 8.3%, the amount of wool sweat has made 12.1%, and the amount of diphilic substances is 3.2%. The ratio of wool fat: wool sweat is 0.70. It is noted that animals of the Caucasian breed have a white wool yolk (94.9%) and a sufficient amount of it (95.6%), which indicates a good consolidation of this trait in the sheep capita.


Synthesis and biological evaluation of compounds of the present invention relates to a spermicide formula I, and their pharmaceutically acceptable salts. The present invention provides a bis (4-substituted-1-piperazinyl thiocarbonyl) disulfide (when n = 0) and alkane -1, n--diyl bis (4-substituted piperazin-1-disulfide acid ester) (when n = 0,1,2, or 3), as shown in Figure 1 of the drawings. These compounds because of their spermicidal activity was found to be useful.


THIS THESIS ANALYSES THE NARRATIVE DISCOURSES THROUGH WHICH (HOMO)SEXUAL IDENTITY IS RENDERED AT THE TURN OF THE CENTURY AND MILLENNIUM IN THE NOVELS OF THE ENGLISH WRITER ALAN HOLLINGHURST. HE HAS WRITTEN FOUR NOVELS SO FAR: THE SWIMMING-POOL LIBRARY (1988), THE FOLDING STAR (1994), THE SPELL (1997) AND THE LINE OF BEAUTY (2004). HE HAS RECEIVED SEVERAL PRESTIGIOUS AWARDS, THOUGH IT IS WORTH NOTING THE MANN BOOKER PRIZE FOR HIS LAST NOVEL. HIS PRODUCTION IS INSCRIBED IN THE LONG ENGLISH LITERARY TRADITION (THOUGH OTHER TRADITIONS ARE ALSO PRESENT), AND PARTICULARLY IN A NUMBER OF GENRES AND WORKS WHICH HAVE BEEN ASSOCIATED WITH SAME-SEX DESIRE AND GAY IDENTITY. THAT IS WHY, AFTER REVISING THE STRAIGHT AND GAY CANONS, THE THESIS TURNS TO THE LITERARY TRADITION PRODUCED AFTER THE LIBERATION MOVEMENTS OF THE NINETEEN SIXTIES AND THE AIDS CRISIS. THUS, THROUGHOUT HOLLINGHURST'S PRODUCTION, IT BECOMES INCREASINGLY OBVIOUS HOW OLD DISCOURSES ARE UPDATED AND USED BY A NEW GENERATION SO THAT GAYNESS CAN BE REFORMULATED IN A NEW TEXTUAL FORM. IN FACT, WITH POSTMODERNISM AND AIDS, ONLY THE TEXTUAL, AND PARTICULARLY THE INTERTEXTUAL, CAN MAKE SEXUAL MARGINALITY VISIBLE AND REPRESENTABLE, ALWAYS FROM AN IRONIC PERSPECTIVE. IN SUM, PAST AND PRESENT PROJECT EACH OTHER AND, OUT OF THIS CONFRONTATION, HOLLINGHURST CAN FIND A SUCCESSFUL, NEW HOMOEROTIC DISCOURSE.


Language use in novel accordance with the context of sentence and according to events that occur in the story such as direct sentences and indirect sentences. The purposes of this study are to know the kinds of modal auxiliary verb and the function used in City of Heavenly Fire Novel written by Cassandra Clare. This study is descriptive qualitative research and object discussed about City of Heavenly Fire Novel written by Cassandra Clare. The data collection techniques are observation and literature review. Data analysis is to analyze sentences that use modal auxiliary verbs in the novel. The research findings are (1) modal auxiliary verb "could" and "would" mostly used in City of Heavenly Fire Novel, the use of modal auxiliary verbs "could" and "would" is 62% more than the use of modal auxiliary verb "will" and "can"; (2) The functions of modal auxiliaries are expressing present and past ability, expressing expectation, requesting action, requesting action, requesting permission, requesting permission, expressing preference, expressing present need or lack of need, expressing past need or lack of need, expressing advice, expressing advice about the past (action not taken), expressing present and past possibility, and expressing probability.


The armature of the special moving-coil machine was a cylinder cup made of conductive metal.In order to study the torque-speed characteristic of the special moving-coil machine,a few prototypes with different poles number and shape of permanent magnet,different rotor material and different rotor length were developed,the torque-speed characteristics of these prototypes were tested,the relationships of the special moving-coil machine torque-speed characteristic with the poles number and shape of permanent magnet,the conductivity of the rotor material and the rotor length were analyzed.The test showed that the electromagnetic torque of the prototype with four magnet pole number was greater than that of the prototype with two magnet pole number,the electromagnetic torque was changed with the rotor length linearly,the relationship of the electromagnetic torque with the conductivity of the rotor material need to be tested and analyzed further.


A global selection of about 70 impact craters comprising multiple different types of dark material deposits, such as single dunes, huge dune fields or thin sand sheets was chosen for this study. By analyzing the mineralogy of these deposits, we want to examine whether there is any correlation between the mineralogical composition and the geographical location, or the dune surface induration, which was established previous works [1], respectively.
For this analysis, MarsExpress-OMEGA spectral data were corrected for solar irradiance and atmospheric absorptions. The mineral detection was done using an IDL routine that applies a rationing technique on corrected data sets. The implemented rationing technique, as well as the spectral parameters (spectral criteria) used for mineral detection, were developed and described in detail by [2]. They include the typical absorption features for every mineral of interest, such as high- and low-calcium pyroxenes, olivine (forsterite and fayalite) and hydrated minerals.
We present a global map showing the mineralogical composition of the selected intra-crater dark material occurrences. Besides the well-known mafic mineral composition (pyroxene and olivine), we could assess that most of the dark deposits show strong pyroxene absorptions. The minor part has olivine absorptions, whereas forsterite occurs in most cases. The results show no mineralogical difference between unconsolidated and consolidated dunes. There is also no correlation between the mineralogical composition and the geographical location recognizable. The unoxidized mafic nature of the material indicates that is was not affected by aqueous weathering. Thus, mechanical weathering could be the major process that caused the comminution of the material. In some places, a portion of the dark material shows absorption features of hydrated minerals indicating that the material has partly underlain a chemical alteration process. The hydration might have been caused by the supply of water, e.g. by melting H2O-frost layers. There is no obvious correlation between hydrated minerals and consolidated dune surfaces. However, it is notable that the positive detection of hydrated minerals concentrates in craters located in Arabia Terra and that all of these intra-crater materials show pyroxene absorptions and no olivine features. Although there is no correlation between the detected mineralogical composition and the dune surface induration, it cannot be excluded that the surface consolidation might correlate to any other minerals that could not be detected by OMEGA.


The Bureau of Mines is developing a method to recover Ni, Co, and Cu from laterites containing less than 1.2% Ni and 0.25% Co. The method consists of the following basic unit operations: (1) reduction roasting, (2) leaching, (3) solvent extraction, and (4) electrowinning. The method reflects three Bureau of Mines objectives: (1) recovery of critical minerals that are domestically in short supply from low-grade domestic laterites, (2) lower processing energy requirements, and (3) solution recycling. This report deals with the extraction of cobalt and the preparation of a suitable cobalt electrolyte by solvent extraction from liquor produced by this method. Nickel and copper are coextracted with LIX64N from an ammoniacal ammonium sulfate leach liquor containing about 1.00 g/1 Ni, 0.30 g/1 Co, 0.03 g/1 Cu, and 0.02 g/1 Zn. Cobalt (III) in the nickel-copper barren raffinate is reduced to cobalt (II) with cobalt metal. Reduction of cobalt (III) to cobalt (II) greatly aids subsequent extraction. Commercially available XI-51 extracts about 94% of the cobalt from the treated raffinate in one stage in a laboratory mixer-settler continuous circuit. Ammonia loaded on the solvent is removed in two washing steps. About 94% of the cobalt then is stripped from the XI-51 more » in one stage with spent cobalt electrolyte containing about 77 g/1 Co and 18 g/1 sulfuric acid (H/sub 2/SO/sub 4/). Electrolytes containing less H/sub 2/SO/sub 4/ also may be used. Preliminary data indicate that coextracted zinc may be removed from pregnant cobalt electrolyte containing 3 g/1 or less H/sub 2/SO/sub 4/ with di-(2 ethylhexyl) phosphoric acid (D2EHPA). « less


The major goal of this group is to generate a basic understanding of various types of oscillations and waves in ionized gases that are relevant to problems in thermonuclear fusion and space research. Our research is a continuation of last year's work with a major item (4) added to our program. 1. Investigations of electromagnetic radiation emitted spontaneously by the plasma, because of thermal and nonthermal fluctuations of the free charges. At present, particular attention is being paid to emission generated as a result of many-body (collective) interactions between the charges at frequencies near the electron plasma frequency. 2. Studies of the dispersion characteristics of small-amplitude stable and unstable waves. We are now looking at the properties of ion sound waves in two collisionless plasma facilities built during the past two years. 3. Investigation of nonlinear plasma phenomena is one of our major goals for the next few years. In this connection, we are particularly interested in the properties of large-amplitude waves, particle trapping, nonlinear Landau damping, parametric coupling of three or more waves, coupling of waves with particles, and turbulence. 4. Studies of fluctuation, particle losses, and turbulence in magnetic multipole geometries. For this purpose, we are constructing a steady-state linear quadrupole (SLIM-1) to be operated in the Francis Bitter National Magnet Laboratory. A linear quadrupole is under construction at the present time. This device (see Fig. XVIII-1) is intended for use as a plasma source for the study of the behavior of a low-P plasma in a simple two-dimensional magnetic field geometry. It will be operated on a continuous, rather than pulsed, basis in order to insure that the plasma is in an equilibrium configuration and to facilitate the collection of information on low-frequency (a) t s (b) Fig. XVIII-1. (c) (a) Side view showing quadrupole bars (A), typical access ports (B), and bar supports (C). (b) End view showing two magnetic field lines; 4' s labels the separatrix, which passes through the axis of the device; 'c labels the "critical" field line, for which 6 f df/B = 0. (c) Cross section of conducting bar showing placement of 21 square, water-cooled, copper conductors inside stainless-steel pipe. phenomena. The device will be located at the Francis Bitter National Magnet Laboratory in order to take advantage of the high-current power supply that is available there. It is anticipated that the power consumption will be approximately 2 MW at the …


Ankle sprains are highly prevalent in the population, and not all of them require medical treatment. It is generally agreed that both the individual and health professionals do not always base their decision on evidence, with a negative impact on the evolution of these injuries, which may evolve to chronicity. The involvement of various professionals in rehabilitation, with different approaches, justifies the standardisation of protocols for action. Goals: This study aims to: 1) identify the acronyms of the protocols of action for the management of soft tissue injuries of the ankle joint and, 2) analyse the evidence of the acronyms. Methods: Integrative Literature Review guided by the research question: "Which interventions are recommended in protocols for the management of acute soft tissue injuries in adults and elderly people?", according to the protocol and eligibility criteria. The search took place between October and December 2020, in the EBSCO, B-On, ISI, SCOPUS and JBI platforms. Results: (The 11 studies in the bibliographic sample are heterogeneous in terms of objectives and type of article, making it possible to answer the research question. The following acronyms/protocols were identified: RICE; PRICE; POLICE; MEAT and PEACE and LOVE. Conclusions: There is no evidence on the effectiveness of these protocols for the management of soft tissue injuries of the ankle joint.  Good practices such as ice application, limb elevation and Optimal Loading are recommended because progressive loading is more likely to restore collagen strength and morphological characteristics.


Cisplatin and etoposide are anticancer drug's used for treatment of various human malignancies. Cisplatin is used for treating solid tumors. The beneficial use of drug is often been mitigated due to its long term toxicities, hepatotoxicity and nephrotoxicity. The drug acts on proximal convoluted tubules of kidney reported as a major side-effect. Etoposide is plant derivative of podophyllotoxin also used for treatment of testicular cancer. In our previous studies we have documented cisplatin drug regimen showed changes in histopathological and antioxidant status of rat. We reported decreased reduced glutathione (GSH) level and increase in lipid peroxidation compared to controls. In present studies we have attempted to study the kinetics of Glutathione-S-Transferase (GST) after cisplatin and etoposide treatment in male wistar rat. GST is a enzyme that metabolizes various reactive intermediates also includes anticancer drugs cisplatin, bleomycin by utilizing significant amount of glutathione. Thus it can be said that cisplatin and etoposide at given dose level showed alteration in GST activity where cisplatin is responsible for inducing the toxic action to liver and kidney and etoposide did not cause any damage to both organs.


A major concern is the inappropriate comparison of patients who received rituximab for various therapeutic reasons with all other kidney transplant recipients. We would argue that these are fundamentally incomparable groups, even with the attempts made to subdivide the control group. For example, the immunological hurdles posed by patients treated with rituximab to allow transplantation across a B-cell positive crossmatch in the presence of DSA are very different than those posed by patients needing treatment for acute rejection. Simply put, neither the experimental nor control groups are sufficiently homogeneous to allow comparison.


A submersible net cage facility for culturing a demersal fish is provided to culture much more quantities of demersal fish by partitioning a space of a demersal fish holding net into many spaces by means of many partition plates, and to adjust a water depth of the holding net freely according to a kind of fish by using a buoyant float, built in an upper frame. A submersible net cage facility for culturing a demersal fish includes: a holding net(10), having a space where a fish moves freely; a demersal fish holding net, having an inside space for the demersal fish, and connected and fixed to a bottom surface of the holding net by means of a connection wire; many partition plates, installed at regular intervals inside the demersal fish holding net so as to divide the inside space into many sections with an equal size; and a demersal fish holding unit(60), having many hollowed pipes which are arranged along a peripheral surface of the partition plates so that the latters are supported by the demersal fish holding net, and which generate a buoyant force by means of their hollowed portion so as to raise the demersal fish holding net in the state that a shape of the latter is maintained.


Supply chain management has received considerable attention in the literature and it is meaningful and important to be able to measure the reliability of supply chains. In the article, the suppliers in the supply chain systems are not independent of each other and the dependency relation may be either linear or nonlinear correlation. From the view of the distribution service process, a copula-based method is proposed for analyzing the reliability of supply chains. In this article, by introducing the model of k-out-of-n: G system into the studies of supply chains, an evaluation method is suggested and the reliability indexes are obtained. Finally, a numerical example is presented to illustrate the results obtained in this article.


To the Editor: Niemann-Pick type A and B diseases (OMIM 257200) are caused by mutations in the sphingomyelinase gene (SMPD1 Accession No. M81780M81781) leading toadeficiencyof sphingomyelinase. The result is an accumulation of lipids, mainly sphingomyelin in reticuloendothelial and other cell types throughout the body. The classic infantile form (type A) is distinguished from the visceral form (type B) because in the latter patients remain free of neurologic manifestations despite massive visceral involvement (1). The Canary Islands are located on the Northwest coast of Africa and have been Spanish since the fifteenth century, although the natives are likely to originate from Northern Africa (2). Our hospital is a reference pediatric center located in Gran Canaria Island, head of the province of Las Palmas, providing a service for a population of ca. 750 000, according to the 2000 population census. The R608del mutation was first described in an Askenazi Jewish patient (3) and has been shown to be the most prevalent in causing Niemann-Pick type B disease amongst patients from Northern Africa (4). Recently, it has been shown to be a common mutant allele in Niemann-Pick B patients from various ethnic origins (5, 6). Accordingly, we screened for this mutation in four pediatric patients from three unrelated familieswith the disease thatwe found inourprovince. DNA was extracted from peripheral blood of the patients using standard protocols (7). The mutation R608del was detected by a direct method developed in our laboratory. PCR was performed on 500ng of DNA for 30 cycles of denaturation, annealing and extension at 94, 62 and 72 C, respectively, using the forward primer R608-F (50-CCC TGC CGT CTG GCT ACT CT-30) and the reverse primer R608-R (50-CTC TGG GAG GCT CCC ATC TG-30), which yielded an amplified product of 96/93 nt for the normal and deleted alleles, respectively. The amplified product was then analyzed in non-denaturing 10% polyacrylamide gel on TBE 0.5 overnight at 150V. The presence of the R608del mutation was confirmed by sequencing the deleted amplicon, for at least one member from each family. The result of the analysis in one family is shown in Fig. 1. Three of the four patients were diagnosed because they have hepatomegaly or splenomegaly and a liver or bone marrow biopsy with blue foam cells. The diagnosis was confirmed by deficiency of acid sphingomyelinase (ASM) activity. The clinical, biochemical and genetic findings of these patients are summarized in Table 1. Although the province of Las Palmas comprises the islands of Gran Canaria, Fuerteventura and Lanzarote, all three families have their ancestors in isolated villages in the center and the north of the island of Gran Canaria. Solely in family B was relatedness between the parents (first cousins) known, but we cannot completely rule out kinship between the parents of family A or C, largely because of their origin, and the high degree


The aim of this study was to investigate trends in volatile substance abuse (VSA) deaths over 25 years. VSA deaths in boys and girls (<18 years of age) fell by an estimated 56% and 64% respectively from the underlying trend, but there was no evidence of any similar step change in either group following the 1999 Legislation prohibiting sales of cigarette lighter refills containing butane to those under the age of 18 years.


The machining and subsequent annealing behavior of an Al{sub 2}O{sub 3}-SiC nanocomposite (Al{sub 2}O{sub 3} + 5 vol% 0.2 {micro}m SiC particles) was compared to that of single-phase Al{sub 2}O{sub 3}. The machining-induced residual line force was determined by measuring the extent of elastic bending in thin disk specimens, and the surface roughness was evaluated by profilometry. The results showed that, when the two materials were subjected to the same grinding conditions, they developed compressive residual stresses and surface roughness values of similar magnitude. The maximum thickness of the residual stress layers was estimated to be {approximately}10 {micro}m for the Al{sub 2}O{sub 3} and {approximately}12 {micro}m for the nanocomposite. A direct linear correlation was observed between the residual force and the surface roughness for different machining treatments. Annealing of the machined samples produced complete relaxation of residual stresses in the single-phase Al{sub 2}O{sub 3}, whereas only partial stress relaxation occurred for the nanocomposite.


My purpose is to compare Berkeley's and Gentile's idealism, interpreting Berkeley's Treatise, §§22-23, and Gentile's reading of this passage. The Italian philosopher finds in Berkeley's master argument the original source of the true idealistic way of thinking, but he believes that Berkeley has not been sufficiently consistent in deducing all the consequences from his new principle. This criticism is the ground of Gentile's actual idealism. Comparing the two positions is very instructive both to elucidate the general issue of idealism and to understand Berkeley's philosophy.


Regional volatile organic compound(VOC) pollution from petrochemical plants has attracted increasing concern recently in Taiwan due to concern of local resident health and the production of tropospheric ozone. 1 Meanwhile, the occasional unpleasant odor of anthropogenic VOCs from petrochemical plants causes discomfort of local residents and leads to protests against the plant's operation. The fugitive VOCs usually last in a short time period and can hardly be detected and characterized in time. Regulation has been implemented by Taiwan EPA (Environmental Protection Agency) to assist the emission reduction and leakage control of anthropogenic VOC by petrochemical plants. However, a cost-effective method has yet been established to monitor VOCs from either emission or leakage of the petrochemical plants due to lack of a fast and accurate instrument with on-site, long-term, and continuous VOC analysis capability. This study aims to assess an effective method which can provide fast and accurate VOC concentration detection for monitoring fugitive gas pollutants on-site at a mega petrochemical plant.


The incidence of posttransfusion hepatitis was significantly reduced by a transmembrane washing procedure on thawed, deglycerolized, previously frozen red blood cells (RBC). The method constitutes mechanical centrifugation, high glycerol concentration, slow freeze and thaw, and a 4-liter washing procedure for deglycerolization. Four cases of histologically proved hepatitis (one icteric, three anicteric) occurred in a control group of 104 recipients receiving 442 transfusions (median 3) of such RBC resuspended in autologous plasma, an incidence of 9 per 1,000. No hepatitis occurred in the treatment group receiving 623 transfusions (or a median of 4 units per patient) of such RBC resusThe incidence of posttransfusion hepatitis was significantly


The article focuses on the role of social infrastructure in improving the quality of life of the population and in improving the demographic situation in the Russian Far East. Description of methods of measuring the need for reproduction of social infrastructure is presented. Based on the example of land rationing, rationing of social infrastructure in the field of education and health care, retrospective assessment of experience of using the normative method of measuring the need for reproduction of social infrastructure in Russia is presented. The value of normative method in the system of formation of social standards has been determined.


In this study, it was aimed to examine the effects of functional training applied for eight weeks on the body composition and some physical fitness parameters of male volunteer paramedic students studying at a university's health services vocational schools. In order to determine the effects of functional training applied for eight weeks on body composition (body weight, height, body fat percentage, body mass index), standing long jump, flexibility, push-ups, sit-ups, speed and balance parameters, a pre-test-post-test protocol was applied and the difference between the two measurements was calculated. Normality and T-Tests were used in the analysis of all parameters. Significance was determined at the p


Adolescent obesity is a leading global problem in the 21st century. It is increasing due to excess snack consumption, low physical activity, not following mindful eating. Objectives of the research were (1) To study consumption of hidden sugars and fats in snacks by adolescents, (2) To conduct market survey of packaged foods and to assess hidden sugar and fat content, (3) To assess dietary pattern and somatic status of subject. Methodology followed was Purposive random sampling of adolescents both girls and boys of age 16-18 years (N=100), questionnaire was constructed and validated, general information, anthropometric measurements and dietary information was collected, data was analysed statistically. Results and findings of this study were as follows, Majority (87) respondents were non-vegetarians and consumed snacks atleast twice daily. 47 respondents skipped breakfast always. 41 percent of respondents overate when hungry due to skipping previous meal. Mean consumption of fat (26 grams) and sugar (28 grams) from snacks. Body mass index reveals that 37 respondents were in normal category, 21 respondents were underweight, waist hip ratio revealed 89 adolescents were obese. 45 respondents were involved in physical activity every day. 21 respondents binged on snacks at midnight as an effect of disturbed sleep. Skipping breakfast, increased the intake of snacks and low physical activity are contributing factors to increased BMI and abdominal obesity which leads to insulin resistance, diabetes, ischemic heart disease, high cholesterol levels and early morbidity in adulthood. There is a dire need for nutrition awareness among adolescence to make healthy food choices.

Key words: adolescent, obesity, snacking, Hidden sugars, fat consumption.


Objective To explore the anesthesia points for attention in hip fracture surgery for older patient with unstable angina.Methods Clinical features of anesthesia in hip fracture surgery of 35 older patients with unstable angina were retrospectively summarized and analyzed.Results 31 cases of patients were treated with combined spinal-epidural anesthesia,3 cases with epidural anesthesia,1 cases with general anesthesia.4 patients received IV dopamine to maintain blood pressure until anesthesia disappear.1 patients had short-term disabilities.There was'nt perioperative death in these patients.Conclusion Hip fracture surgery of older patient with unstable angina can be successfully implemented by reducing impacts of all kinds of stress factors,stable anesthesia,approprate application of cardiovascular drugs.


The benzoin group caged compound has received strong interests due to its excellent photo-deprotection properties and wide use in chemical and biological studies. We used time-resolved infrared spectroscopy to investigate the photochemical reaction of the benzoin caged compound, o-(2-methylbenzoyl)-DL-benzoin under 266 nm laser irradiation. Taking advantage of the specific vibrational marker bands and the IR discerning capability, we have detected and identified the uncaging product 2-methylbenzoic acid, and two intermediate radicals of benzoyl and 2-methylbenzoate benzyl in the transient infrared spectra. Our results provide spectral evidence to support the homolytic cleavage reaction of C–C=O bond in competition with the deprotection reaction. Moreover, the product yields of 2-methylbenzoic acid and benzoyl radical were observed to be affected by solvents and a largely water containing solvent can be in favor of the deprotection reaction.


This article undertakes an intrinsic case study of ISIS's social impact on the citizens of Mosul, Iraq directly after its occupation thereof. It does so, moreover, within the framework of ISIS's Takfiri ideology as rooted in its history so as to provide a basis for anticipating the fate of that ideology in the post-ISIS period. This issue is particularly important in light of contemporary debates regarding the essentiality of territory to ISIS's ideological survival. Adding to the importance of this debate is the fact that Mosul was declared ISIS-free in July 2017. Thus, by outlining the social impact of ISIS's ideology at a time in which ISIS had free reign within territory that it once predominantly occupied, this article provides a basis for anticipating the decline of ISIS's ideology.


enough) asked about NIR calibrations is whether the calibration only works because Y, which is the quantity of interest, is strongly correlated with Z, some other quantity that we already know can be measured by NIR. For example, it is possible to get quite a reasonable looking calibration for the volume of test-baked loaves from NIR measurements on the wheat flour used. However, we know that NIR can measure the protein content of flour, and we know that this protein content is one of the major determinants of loaf volume. So is the NIR just measuring protein quantity and its contribution to loaf volume, or is it able to measure something more, the elusive protein quality perhaps? It might be argued (though not by me) that if a calibration works it does not matter why it works, but I hope most researchers would rather know whether they really have achieved something new or whether they are just recycling an old application.


A "table-top" high power laser has been used to generate beams of accelerated electrons up to energy of 20 MeV from interactions with underdense plasmas. The energy spectrum of these beams was measured using a magnetic spectrometer and proof-of-principle experiments were performed to evaluate the suitability of these beams for electron radiography applications.


Kaunas University of Technology, Institute of Synthetic Chemistry, Radvilėnų pl. 19, LT-50270 Kaunas, Lithuania Condensation of 1-propyland 1-(3-phenylpropyl)imidazo[1,2-a]indoles with ortho-hydroxy-substituted aromatic aldehydes afforded 1'-[N-propyland N(3-phenylpropyl)carbamoyl]methylspiro[1-benzopyran-2,2'-indoles]. Treatment of the latter with potassium hydroxide gave bridged oxazepino[3,2-a]indole derivatives.


Introduction: One of the most important questions raised in the wake of the Galileo mission to Jupiter is that of the composition of the dominant silicate lavas on intensely volcanic Io [1-4]. Some spacecraft and ground-based data have been interpreted to suggest that high-temperature ultramafic lavas have erupted at some locations. Such lavas are the result of a high degree of mantle melting, at higher temperatures than for basalts. As the degree of melting within Io is intimately linked to the location and magnitude of tidal heating, determining lava eruption temperatures is a high priority for any Io-dedicated mission. One way of constraining composition is by measuring the temperature of the lava as it erupts. As noted previously (e.g., [3]), this is not a simple task using only remote-sensing data. To differentiate compositions based on remote observations of temperature requires the careful identification of areas where the highest temperatures can be isolated. This depends on the style of volcanic activity – how lava is physically erupted and emplaced on Io's surface – which can be modeled with multispectral infrared observations, even at low spatial resolutions. Models of thermal emission based on eruption style are then used to determine the temperature and area distribution present. Only certain styles of volcanic activity are suitable, those where thermal emission is from a restricted range of surface temperatures close to eruption temperature. Such processes include large lava fountains [1]; fountaining or vigorous overturn in lava lakes [2]; lava tube skylights [3]; and transient explosions [5]. Eruption characteristics are given in Table 1. Overcoming observation uncertainties: Problems... [6, 7]: (1) Lava surface temperatures can change very rapidly, potentially more quickly than typical observation integration times and/or the time between acquiring data at different wavelengths. (2) The intensity of thermal emission from Io's volcanism is so much higher than even sunlit scenes that detector saturation is a common problem. ...and solutions [6, 7]: (1) Acquire data quickly! Monitoring at 60 Hz in a clear bandpass establishes thermal source stability if stable, the temperatures derived from colour data acquired at ~0.1-1 second separations will be robust. (2) Focus attention on eruption styles that provide more stable high temperatures (i.e., skylights – see Table 1). (3) Collect data at a variety of wavelengths so the hottest lavas in the scene are not saturated in the shorter wavelengths, while cooler active lavas are still imaged at the longer wavelengths (also yielding the full temperature and area distributions at each location). We can achieve these solutions by careful instrument and observation design, informed by knowledge of Io's varied styles of volcanic activity, ranging from massive thermal outbursts (e.g., [7]) down to individual lava tube skylights [3]. Recognising useful volcanic eruption styles: Estimation of lava eruption temperature from remote sensing relies on imaging eruptions where sufficient area at peak temperatures are exposed, even where sources are sub-pixel [7]. Different eruptions have different spectral radiance spectra and magnitudes of thermal emission that can span over six orders of magnitude [6,7]. Desirable eruption styles are shown in Table 1, with some pros and cons. Figures 1 and 2 show how target eruption styles and processes are constrained from measurements of thermal emission at two different wavelengths. Figure 1 shows the magnitude of different eruption types seen on Io. The desirable styles of activity lie within the red ovals, and are described below.


New horizontal and vertical trim dipoles have been designed for the Fermilab Main Injector (FMI) and are being assembled in the Fermilab Technical Division. Magnets are 42.6 cm in length (30.5 cm steel length) and have similar cross-section dimensions. The horizontal (vertical) magnet gap is 50.8 mm (127 mm) and the target integrated strength is 0.072 T*m (0.029 T*m). The major design effort lay in making air cooling possible for these magnets. This report presents the magnets' thermal and magnetic properties and discusses the limitation on excitation current.


18011 Background: Therapeutic vaccination of melanoma patients with tumor specific antigenic peptides has been associated with increased frequency of anti-vaccine CTL precursor frequencies in peripheral blood and objective tumor regression in a low percentage of patients.

METHODS
We investigated the safety and activity of two autologous dendritic cell-based vaccines in 2 sequential cohorts of advanced melanoma patients. Patients first underwent a leucapheresis. Following enrichment in a semi-closed culture system using Cell Factories (Nunc), adherent cells were cultured in RPMI 1640 medium supplemented with 1% heat-inactivated autologous plasma, 500U/ml IL-4 and 1000 U/ml GM-CSF for 6 days and cryo-preserved. Upon thawing, DC were pulsed with 8 peptides or electroporated with synthetic mRNA encoding 7 antigens. Dendritic cell vaccines were administered by intradermal and subcutaneous biweekly injections for a total of 6 times (= cycle 1). Thereafter vaccination was repeated every 6w until clinical deterioration or patient refusal. Frequencies of blood anti-vaccine CTL were estimated by in vitro restimulation in limiting dilution conditions followed by detection with tetramer assay.

RESULTS
Fifteen patients were recruited (9M/6F; median age was 49 y, range 28-81). Seven HLA-A2 patients were treated with peptide pulsed DC (cohort A) and 7 patients (4 HLA-A2 and 3 HLA-A1) with mRNA electroporated DC (cohort B). One patient was sequentially treated with both vaccines. Five patients in cohort A and 3 patients in cohort B completed the first treatment cycle of 6 bi-weekly vaccinations (cycle 1 is ongoing in 3 patients of cohort B). Toxicity was limited to grade 1 or 2 local skin reactions at the vaccine administration sites in all patients. In cohort B one patient qualified for stable disease and 2 other patients with progressive disease displayed regression of individual metastases. A >10-fold increase in CTL precursor frequency was observed in 2 out of 3 patients of cohort A that have been analyzed at present.

CONCLUSIONS
Vaccination of melanoma patients with peptide pulsed or mRNA electroporated autologous DC vaccines was found to be feasible and safe. Updated results will be presented at the meeting. [Table: see text].


Target tracking has traditionally focussed on the use of kinematic information such as bearing, range, position, or speed. In some cases it is possible to extract additional target information that may be useful in the maintenance of reliable tracks or the establishment of target type or identity. Several methods have been proposed for the use of feature information in target tracking. In this paper we discuss and evaluate featureassisted tracking using a feature component in the cumulative likelihood ratio used for track initiation and maintenance in a multihypothesis (MHT) tracker. The data set used in the evaluation, PACsim, was specifically developed to investigate the use and value of feature information in multistatic tracking and has been the subject of collaborative analysis by the Multistatic Tracking Working Group (MSTWG).


We present a novel method of measuring the pipe wall thickness using the resonance of the circumferential (C-) Lamb wave generated by a piezoelectric ring-shaped sensor (PS). The PS is a special device for an axially propagating torsional wave; however, the C-Lamb waves are generated simultaneously as spurious signals owing to the structure of the PS. Particularly under resonant conditions, the C-Lamb waves are dominantly generated, distorting the axially propagating wave. In this method, these troublesome spurious signals are used effectively for the measurement of the wall thickness under the PS location that is a dead zone of the PS itself. The method can compensate for its drawback, namely, the dead zone problem, without using additional instruments. In this study, the mechanisms of the generation and resonance of the C-Lamb waves were first explained. Secondly, the principle of the wall thickness estimation utilizing the resonance of the C-Lamb waves was proposed. Finally, experimental verifications were carried out. The estimated wall thicknesses agreed very well (maximum 1.5% error) with those measured by a micrometer caliper under suitable resonant conditions.


To accurately predict passengers' demand for ride-hailing, increase transport capacity in some areas directionally, make it easier for passengers to book ride-hailing, and thus enhance passengers' travel experience, based on BP neural network model, combined with 2015-Mak-2019 ride-hailing demand change data, and based on MATLAB platform, the demand trend of 20202024 is forecasted. The results show that the demand for shared cars and rides will increase rapidly. Demand for shared bikes and taxis is rising slowly.


In this presentation, we investigate the identifiability of the climate state by these limited data. That is, we calculate the precision with which it is possible to estimate the climate state. In contrast to the regression-based and frequentist methods which have been widely adopted, we use an optimal data assimilation methodology to treat the problem as one of Bayesian estimation. Our initial investigations are based on a perfect model paradigm, in which pseudoproxy data are generated by a single model 'truth' run, with the aim being to reconstruct (as far as possible) the full state from these limited data. Using pseudoproxy data from a model run enables us to validate the method precisely.


Aims:  To evaluate the response and progression‐free survival (PFS) of Malaysian patients with advanced lung adenocarcinoma and unknown epidermal growth factor receptor (EGFR) mutation status treated with gefitinib.


The measurement of corporate reputation is a growing issue for practitioners and academics. The corporate
reputation measurement literature concentrates on the United States and European countries. There is an obvious
lack of studies especially on the development of corporate reputation measurement in Malaysia. While interest
in the development of corporate reputation measurement has gained momentum in the last thirteen years, a
precise commonly agreed upon the measurement is still unclear. Therefore, this paper set out to develop a
conceptual model for developing an alternative measurement of corporate reputation within the Malaysian
context. Literature review, conceptual model, hypotheses development and research methodology are discussed.
These will allow companies in Malaysia to develop a new measurement of corporate reputation.


FORMAT OF PROFESSIONAL LEARNING GROUP: The format of this professional learning group will be a train-the-trainer model. THESE GROUPS ARE NOT FOR TECHNOLOGY NOVICES. Participants should possess INTERMEDIATE TO ADVANCED TECHNOLOGY SKILLS. Participants will be instructed on specific technology integration strategies, best practices, resources, and tools. They will then be able to research and develop methods for sharing these strategies, best practices, resources, and tools with the teachers and students at their schools. Participants will be expected to maintain an implementation log to document use of the strategies. Sharing time with other participants as well as classroom observations and model lessons may also be included in the group meetings.


Study dissolution behaviour of ketoprofen through optimum chitosan-CMC microcapsule has been carried out. Into228.6 ml of 1.0% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 ml of CMC solution was added with concentrationvariation of 0.075; 0.0875; and 0.10% (w/v). Afterwards, 7.62 mL of glu was added slowly under stirring, withconcentrations varied: 3; 4.5; and 6% (v/v). All mixtures were shaked for 20 minutes for homogenization. Into eachmicrocapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Everymixture was then added with 5 ml of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature.Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. Thedissolution behaviour of optimum ketoprofen microcapsules were investigated in gastric and intestinal medium.Microcapsule morphology before and after dissolution as well as empty microcapsule (blank) were observed withSEM. Spray drying process had successfully coated ketoprofen in chitosan-CMC microcapsule. Optimization byusing Minitab Release 14 software showed that among the microcapsule compositions studied, CMC and glu of0.0925% (w/v) and 3.01% (v/v), respectively, optimum to coat ketoprofen at constant chitosan concentration 1.0%(w/v). Result of SEM morphology and In vitro dissolution profile showed that ketoprofen in chitosan-CMCmicrocapsule was relatively well than chitosan-guar gum microcapsule. Kinetically, dissolution of ketoprofen frommicrocapsule in intestinal pH condition was first order with release rate constant, k, of 7.285  10-4 % min-1 andrelease half-time, t1/2, of approximately 15 hours.


Although economic texts are generally examined in terms of their specialized discourse, they include numerous conceptual metaphors that conceptualize economy or economy-related issues in different ways. These metaphors serve various functions such as decreasing ambiguity and incomprehensibility in economic discourse. For these reasons, metaphors have become an important constitutive part of the analysis of economic texts. Similarly, translation of metaphors in economic discourse has attracted the attention of a growing number of translation scholars in recent years. This study aims to make a contribution to the study of metaphor and metaphor translation, focusing on the most frequent metaphorical expressions in a widely read multinational business magazine, Fortune. After identifying the types of metaphors in the source texts, they have been compared to their translated versions in order to analyze translation strategies and their effectiveness in terms of rendering the metaphoricity in the target texts. In order to describe the procedures used by the translators to render metaphorical expressions, the theoretical framework proposed by Peter Newmark (2007) for translating metaphor has been adopted. As a result of a detailed analysis, it has been found out that the most frequently used translation procedures are converting the metaphor into sense and reproducing the same image in the target language. On the whole, it can be concluded that the translators have had difficulty in retaining some of the metaphors and hence resorted to rendering their meaning in the target text. For this reason, it is possible to claim that translation of metaphors create a linguistic constraint for translators working on economic texts.


The present study aimed to validate the Satisfation With Life Scale (SWLS; Diener, Emmons, Larsen, & Griffin, 1985) and the Core Self-Evaluations Scale (CSES; Judge, Erez, Bono, & Thoresen, 2003) with a sample of Portuguese managers (N = 108). The SWLS assesses the cognitive component of subjective well-being, also described as the perceived satisfaction with the quality of one's life. The CSES focuses on the person's core self-evaluations, and includes four personality dimensions: self-esteem, generalized self-efficacy, neuroticism, and locus of control. The findings suggest that both instruments present adequate reliability indices and that the original theoretical constructs presented by the authors are partially observed in the dimensional structure of the scales, in the current Portuguese sample, with greater similarity in the SWL. In addition, a positive and significant correlation was observed between personality traits measured with the CSES and life satisfaction assessed with the SWLS, particularly for the items reported to perceived self-efficacy.


This work, published for the first time in Italian, wishes to demonstrate that the art of reasoning demands, as primary requisite, an intense 'love towards truth' and calls for the individuation of some types of reasoning (or ways of reasoning) not mutually reducible, in which the nature of principles of inference is radically different. Once we know the reasons (the principles of inference) by dint of which the various types of reasoning permit true conclusions, given the truth of the premises, then also the conditions of validity for any type of reasoning are easily enucleable.


Hardening mechanism associated with post-firing heat treatment of softening heat treated and then firing simulated Pd-Ag-Au alloy for bonding porcelain was examined by observing the change in hardness, crystal structure and microstructure. By post-firing heat treatment of as-cast, solution treated and pre-firing heat treated specimens at 650 ℃ after casting, the hardness value increased within 10 minutes. Then, hardness consistently increased until 30 minutes, and gap of hardness value among the specimens was reduced. The increase in hardness after post-firing heat treatment was caused by grain interior precipitation in the matrix. The softening heat treatment did not affect the increase in hardness by post-firing heat treatment. The precipitated phase from the parent Pd-Ag-Au-rich α phase with face-centered cubic structure by post-firing heat treatment was Pd3(Sn, In) phase with face-centered tetragonal structure, which has lattice parameters of a 200 =4.0907 Å, c 002 =3.745 Å. From above results, appropriate post-firing heat treatment in order to support the hardness of Pd-Ag-Au metal substructure was expected to bring positive effects to durability of the prosthesis.


The aim of this paper is to study the roll played by arbitrators nowadays in the framework of international commercial arbitration and, more precisely, to establish whether impartiality and independence, compulsory principles in the conduct of any judge are applicable in the same way to arbitrators, especially for those appointed by the parties.


A simple method for the synthesis of new bithienylethenes bearing a functional group on the cyclopentene moiety is developed. Three new photochromic compounds (4a, 4b, 4c) have been successfully synthesized through this simple method, and exhibit good photochromic properties with alternate irradiation of ultraviolet and visible light. Furthermore, the ?uorescence of compound 4a, which bears a quinoline unit on the cyclopentene, can be modulated via optic and proton dual inputs. Upon excitation by 320 nm light, 4a emits a strong ?uorescence at 404 nm. After irradiation with 254 nm light, the emission intensity is reduced due to the ?uorescence resonance energy transfers (FRET) from quinoline unit to bithienylethene unit. Moreover, on addition of H+, the fluorescence is quenched completely due to the protonation of the quinoline. In addition, both the FRET and protonation process are reversible, which indicates a potential application in molecular switches and logic gates.


I would like to congratulate Md Yusof et al (1) on an excellent, large-scale study, focusing attention to an important but underestimated clinical problem in autoimmune rheumatic disease patients (AIRD) treated with B-cell targeted therapies (BCTT). Their data confirms that secondary hypogammaglobulinemia can be an important clinical problem in this group. The commitment of the clinicians in following recommendations for BCTT monitoring is admirable, whereby very high rates of immunoglobulin measurements were achieved in routine clinical settings.


The setting of this paper consists of a map making \nice" returns to a reference set. Criteria for the existence of equilibria, speed of convergence to equilibria and for the central limit theorem are given in terms of the tail of the return time function. The abstract setting considered arises naturally in diierentiable dynamical systems with some expanding or hyperbolic properties. This paper is part of an attempt to understand the speed of mixing and related statistical properties for chaotic dynamical systems. More precisely, we are interested in systems that are expanding or hyperbolic on large parts (though not necessarily all) of their phase spaces. A natural approach to this problem is to pick a suitable reference set, and to regard a part of the system as having \renewed" itself when it makes a \full" return to this set. We obtain in this way a representation of the dynamical system in question, described in terms of a reference set and return times. We propose to study this object abstractly, that is to say, to set aside the speciic characteristics of the original system and to understand its statistical properties purely in terms of these recurrence times. Needless to say, if we are to claim that this approach is valid, we must also show that it is implementable, and that it gives reasonable results in interesting, concrete situations. The ideas described above were put forth in Y]; they continue to be the underlying theme of the present paper. In Y] we focused on mixing at exponential speeds. One of the aims of this paper is to extend the abstract part of this study to all speeds of mixing. Of particular interest is when the recurrence is polynomial, i.e. when the probability of not returning in the rst n iterates is of order n ?. We will show in this case that the speed of mixing is of order n ?+1. More generally, let R


The invention discloses a construction method of an inertial block vibration isolation base of a centrifugal water pump. The construction method of the inertial block vibration isolation base of the centrifugal water pump comprises the steps of determining the plane view size of the inertial block vibration isolation base, determining the thickness of the inertial block vibration isolation base, preparing a damping spring, manufacturing the inertial block vibration isolation base of the water pump, pouring concrete, and installing the inertial block vibration isolation base and the damping spring. The construction method of the inertial block vibration isolation base of the centrifugal water pump is convenient to construct, is environmentally friendly, and can effectively reduce low and medium frequency noise sources generated by the centrifugal water pump and other equipment. Safety potential risks which happen to equipment, instruments and building supporting structures and are caused by vibration produced by inertia force of equipment are effectively lowered.


Art's function has allowed artists to express themselves for centuries. Art was once created solely for religious reasons, especially with the rise of the Catholic Church. The Industrial Revolution and the church's declining influence in the 19th century opened people's eyes to emotion and imagination, which Romanticists later portrayed artistically. This led to nature mysticism and landscape paintings. Similarly, St. Ignatius' Ignatian Spirituality corresponds to the divine yearning in nature. Spirituality and art can go hand in hand, say Jesuit priest-artists. Mystical landscapes reveal humanity's spiritual connection to nature. Artists explore emotion and spirituality through monochromatic art because it can provoke deeply personal experiences
My art explores landscape's spirituality. I like how it evokes spirituality, longing, and comfort.
Keywords: Spirituality; Papar Landscape
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by E-International Publishing House, Ltd., UK. This is an open-access article under the CC  BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behavior Researchers), ABRA (Association of Behavioral Researchers on Asians), and cE-Bs (Centre for Environment-Behavior Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7iSI9.3941


and highlights differences between differing imperial approaches and those of the indigenous populations, allowing for an incredibly nuanced presentation of shared ideas and practices applied to commodities across empires, concluding with their legacies. Environmental historians too will find much of interest in Ross's approach to explaining how the latter stages of empire helped influence future environmental development policy and thinking.


This paper aims to analyze the dayah negotiations in Aceh in the face of modernity. On the one hand, the dayah needs to maintain identity by caring for the uniqueness of the system and methods of religious teaching in accordance with methods that have been taught from generation to generation. Text review determined by the dayah teacher (teungku) starting from the criteria of the dayah student (santri) and the system of evaluation and standardization of abilities. Dayah also takes care of identity by forming the personality of the santri through the development of independence of life in the dayah. The dayah system has succeeded in giving birth to a society that understands Islam in a deep, comprehensive and far-reaching understanding of religion. More importantly, dayah education alienates santri from radical thought patterns and makes them tolerant humans. The results of this study show that Dayah Al-Aziziyah who cared about modernity by not losing its identity successfully spread religious teachings well in Aceh. Negotiations with modernity also made Al-Aziziyah a little left with some of its educational principles such as delaying the big vision to make Islamic Higher Educatin (Sekolah Tinggi Agama Islam, STAI) Al-Aziziyah Samalanga exactly like the dayah manyang (higher dayah level) that had been popular in Aceh.


A real-valued bivariate 'Estimation of Distribution Algorithm' specific for the ab initio and full-atom Protein Structure Prediction problem is proposed. It is known that this is a multidimensional and multimodal problem. In order to deal with the multimodality and the correlation of dihedral angles φ and ψ, we developed approaches based on Kernel Density Estimation and Finite Gaussian Mixtures. Simulation results have shown that both techniques are promising when applied to that problem.


The thesis is to explore and prove that most of the Cantonese speakers find it difficult to pronounce the English voiced fricative / v / if they are adult learners according to the Contrastive Analysis Hypothesis (CAH), and thus, make it to another sound / w / instinctively although I can not prove why those Cantonese speakers will have this problem. The conclusion is most of Cantonese speakers have negative transfer when they produce the consonant fricative /v / if it is followed by a vowel(s) while in otherwise cases, no negative transfer have been found.


The structure of the by-products which are formed during the ring closure to morphinans from the corresponding octahydro-iso-quinolines has been elucidated. They are compounds of apomorphine-like structure: 6-methyl- (benzyl- or allyl-)-10-hydroxy-1,2,3,3a,5-6,6a,7,11b, 11c-decahydro-4H-dibenzo-[de, glquinolines] (VII, XV, XVII).


ABSTRACT This paper provides a critical analysis of the average molecular structure determination For high boiling and nondistll-lahle fractions in fossil fuels. The emphasis is on molecular weight distribution and compound-class composition. The wide molecular weight distribution, resulting from the different volatility of the various chemical classes of compounds comprising these complex mixtures, is demonstrated to be the major limitation.


Purpose
This paper aims to recommend a framework that serves as a practical work tool for conducting risk-based Shari'ah audit (RBSA) in Islamic financial institutions (IFIs).

Design/methodology/approach
Qualitative research method was used through critical in-depth content analysis of documented literature to generate deep insights, further supported with a hypothetical illustrative case study application of the framework on an Islamic bank, aimed at bringing the framework to a practical, near real-life scenario.

Findings
A robust RBSA framework has been developed which focuses on Shari'ah non-compliance risks to systematically and practically arrive at a rated opinion on the level of an IFI's adherence with Shari'ah rules and principles as recommended by the Accounting and Auditing Organization for Islamic Financial Institutions, aimed to safeguard the IFI and promote financial system stability at large.

Research limitations/implications
Practical realities limited the study to the use of a hypothetical case study bank. Future researchers can apply the framework to a real case study of diverse IFIs for effective contextual recalibration in diverse jurisdictions.

Practical implications
This paper aids the development of both internal and external Shari'ah audit practice using the risk-based approach.

Social implications
The RBSA framework contributes to promoting public trust and confidence in the Islamic finance industry.

Originality/value
This paper has proposed this RBSA framework as a practical work tool for Shari'ah auditors in their engagements and regulators in promoting sound governance and financial system stability. It provides foundation for future researchers in the field.


William L. Rivers and William T. Slater (eds.) Aspen Handbook on the Media: 1975-76 Edition (Aspen Institute Program on Communications and Society, 360 Bryant Street, Palo Alto, Calif. 94301—$6.95/3.95) Richard Dyer MacCann and Edward S. Perry's The New Film Index: A Bibliography of Magazine Articles in English, 1930-1970 (New York: Dutton, 1975—$35.00)


Abstract Both radiant and forced convective heat flow were measured for a prototype rowing headgear and white and black cotton caps. The measurements were performed on a thermal manikin headform at a wind speed of 4.0 m · s−1 (s = 0.1) in a climate chamber at 22.0°C (s = 0.05), with and without radiant heat flow from a heat lamp, coming from either directly above (90°) or from above at an angle of 55°. The effects of hair were studied by repeating selected measurements with a wig. All headgear reduced the radiant heat gain compared with the nude headform: about 80% for the caps and 95% for the prototype rowing headgear (P < 0.01). Forced convective heat loss was reduced more by the caps (36%) than by the prototype rowing headgear (9%) (P < 0.01). The radiant heat gain contributed maximally 13% to the net heat transfer, with or without headgear, showing that forced convective heat loss is the dominant heat transfer parameter under the chosen conditions. The results of the headgear – wig combinations were qualitatively similar, with lower absolute heat transfer.


In this paper, we investigate the potentials of distributed generation (DG) in a medium-sized Swiss city. We show the role of private households in the sustainable energy transition process induced by Swiss energy policy. For the analysis, we define six scenarios that enable us to study the potentials and impacts of different combinations of DG technologies in terms of costs, CO2 emissions, and amounts and shares of DG provided by non-industrial end-users (essentially private households and the services sector). Three variants are investigated, one with real electricity costs and CO2 emissions, one with increased electricity costs (e.g., construction of new power plants), and one with increased CO2 emissions (e.g., due to the planned nuclear phase-out in Switzerland). We find that non-industrial entities can play an important role as prosumers. They mitigate the need for centralized generation. Within a scenario where the non-industrial energy end-users install water-water heat pumps and photovoltaics, a total reduction of the gas procurement from the grid is possible whereas the electricity demand from the grid increases by 24%. This scenario reveals higher DG electricity costs in comparison to conventional electricity supply, but the total costs of energy supply decrease due to the elimination of gas supply, and the CO2 emissions can be reduced by 68%.


This thesis considers one of the most widely debated topics in modem European history: why the men of the Einsatzgruppen (mobile killing squads following the Wehrmacht as they advanced into Russia) participated in massacres of supposedly "undesirable" people. Although this topic has been discussed for many years, to date there has been no definitive consensus formed. This thesis examines issues of the official SS publication Das Schwarze Korps and records from the Nuremburg Trials ( contained in the Winfield B. Hale papers in the University of Tennessee's Special Collections Library) in order to bring both new evidence and a new opinion into this debate.


A new approach for microstructuring of aluminum and alumina surfaces based on localized anodization of aluminum is described. It is based on the self-organized equilibrium at the metal/oxide interface and dynamic interactions between individual oxide growth sites. Hexagonal and square closed-packed arrays of hemispherical and pyramidal features from alumina and aluminum on the micrometer scale were prepared. Potential applications of such microstructured surfaces are discussed.


A comparison of two algorithms for modeling the diffraction of an electromagnetic field on the axicon with a high numerical aperture in linear polarization of the illuminating beam. We compare the integral method based on the plane waves expansion and the method of finite difference in time domain FDTD. The integral method, has shown the suitability for the detection of the major trends, which are then investigated more accurate by method FDTD. When using the computer package Meep for the calculation of FDTD has been investigated dynamic changes of the central spot size at high numerical aperture diffractive axicon.


Pedaliodes primera, sp. nov. Habitat: Bolivia, near Cusilluni. Expanse, 2.25 inches. Head and palpi, dark brown, nearly black, Antennæ, above, nearly black; beneath, dark rust colour. Legs, brownish. Thorax, black with brownish hairs. Abdomen, the same but lighter beneath. Upper side of fore wings, entirely dark blackish brown. The hind margins are dentated, especially so on lower wings, The marginal interspaces of fore wings have a prominent white thread.


In this article an attempt was made to analyse the stock, output, and incomes in individual agricultural farms in Poland, in comparison with farms from the other EU countries in the year 2006. Research was based on the FADN database. The research showed, that (among other things) the Polish average individual farm had a four time lower the balance's sum than the medium one in the EU, and the average output and family farm income were about three times lower in Poland than the average in the Union. The highest share of stock in the balance's sum in Poland three direction of production had: permanent crops combined, specialist other field crops and specialist orchards – fruits. While in the Union the highest stock had the specialist wine. According to the regression's models, in Poland the positive influence on the increase of family farm income had stock, crops and livestock output. In the Union positive influence on an income's growth had crops and livestock production and negative influence had the stock.


The order Diptera(Insecta)is one of animal groups most successful in the colonization of mineralized shallow aquatic and semiaquatic environments.At the same time,the taxonomic composition of Diptera,their role in


Consumer Generated Media (CGM) has a significant impact on on companies' product marketing strategies. This paper illustrates development of opinion analysis service for marketing research, WOM Scouter. Then we present an algorithm of associated topic extraction, which is one of main features in WOM Scouter. Associated topic extraction finds out competitive products from blog entries commenting on a specified product. The main feature is to apply product ontology in addition to natural language processing. By looking up a term on product ontology, the product domain is identified in blog entries, and general nouns are excluded. Another feature is to evaluate an importance of each product by means of two kinds of smoothing functions based on link popularity and document frequency. The experimental evaluation shows that the proposed algorithm is closer to blog readers' impression than TF-IDF.


In 2016 Montenegro and America shared a common problem – Russian meddling in the democratic process of both countries. According to an official assessment from American intelligence agencies, Russia was involved in an obstruction of the American presidential elections. During the 2016 October election night in Montenegro, Russian citizens together with individuals from Serbia and Montenegro, planned to kill former Prime Minister Milo Djukanovic and overthrow his pro-Western government. Russian nationalists, members of the Russia's military intelligence service GRU, were involved in the planned action with the goal of stopping Montenegrin accession to NATO. Officially Moscow denied its involvement in both cases. The aim of this article will be to offer answers to the dilemma – how did it happen that Montenegro, after a clear commitment to become the next member of NATO, has found itself in the center of the Russian sphere of influence? Moreover, this article is written with an intention to clarify how modern techniques of Russian hybrid warfare became visible in the case of Montenegrin accession to NATO.


Several extensions to the capacity rating (CR) methodology are developed in this paper. The CR index is related in analytical models to the flow of work which is achieved over a planning period for both single and tandem work centre configurations. Statistical dependency between workload and availability is discussed and included in the flow models. Implications of applying the methodology to a series of periods in a planning horizon are clarified. Results collectively provide direction in applying the CR methodology in the planning process


Abstract : Synchronization offers the Joint Force Commander (JFC) the ability to add synergism to his unified effort to achieve desired results. Today, synchronization of joint forces takes on great importance. Synchronization is addressed throughout Joint Doctrine and to further define it deprives the JFC of initiative and creativity at the operational level. As the link between the strategic and operational levels of war the JFC must synchronize not only his assigned forces at the operational level, but also the total effort of his forces with political, economic, and social actions at the strategic level. To illustrate the concepts and importance of synchronization, this essay first analyzes the role of synchronization in the German invasion of Norway; second, investigates the adequacy of current doctrine in its treatment of synchronization, focusing on Joint Publication 3-0, Doctrine for Joint Operations (JP 3-0) and Army Field Manual 100-5 Operations, (FM 100-5); third, addresses the vertical and horizontal components of synchronization and concludes with an example of modern application of synchronization in the coalition defeat of Iraq in 1991.


New experimental methods at rare-isotope facilities including in-flight separation, storage rings, and traps, setups for reaction studies with beams of exotic nuclei in reversed kinematics and large gamma arrays give new insights into the structure of atomic nuclei at the limits of stability. The discoveries of new isotopes and elements, as well as new phenomena including one and two proton decay, nuclear halos and skins as well as coexistence of nuclear shapes will be discussed. Workhorses are the UNILAC and SIS accelerators in combination with the in-flight separators SHIP and FRS. Physics at the ESR storage ring at GSI addresses the interaction of atomic and nuclear physics and large-scale explorations of the landscape of nuclear masses. A brief outlook on the future, NUSTAR at FAIR will be given.


Purpose: The study demonstrates an antibacterial activity and effect of perillyl alcohol (POH) on the modulation of the inflammatory response of macrophages in vitro. Main methods: The minimum inhibitory concentration (MIC) and minimum bactericidal (MBM) of POH on periodontal pathogens were determined by macrodilution and subculture, respectively. The cytotoxicity of POH on RAW 264.7 macrophages was assessed by Trypan Blue and MTS. The effect on cell proliferation was evaluated by Trypan Blue at periods of 24, 48 and 72 hours. The production of reactive oxygen species (ROS) was analyzed by flow cytometry and the M1/M2 profile by the gene expression of TNF and arginase1 by real-time PCR. Key findings: POH was effective against P. gingivalis (ATCC 33277) and F. nucleatum (ATCC 25586) with MIC = 250 μg / mL. Up to 100uM, no cytotoxicity was observed on macrophages. Cell proliferation was inhibited from 48 hours at 100μM (p <0.05) and 250μM (p <0.01). POH increased ROS production at both 10μM and 100μM (p <0.05) in unstimulated cells. PMA-induced production of ROS was not affected by POH, whereas 100 uM significantly reduced LPSinduced ROS. Expression of TNF was not affected by POH in unstimulated cells or in cells polarized to M1 phenotype, whereas both concentrations of POH reduced (p<0.05) the expression of arginase-1 in M2-polarized macrophages. Significance: POH has antibacterial activity against periodontal pathogens and reduced proliferation of murine macrophages without significant cytotoxicity at concentrations up to 100μM. In addition, POH did not affect ROS production by macrophages and favored the M1-phenotype, as expression of arginase-1 was inhibited in M2-polarized macrophages.


The Carnegie College Classification Method(2005) carries out the most thorough innovation in its classification framework,classification standard,classification system and the presentation form.The British higher education experienced the changes from the binary system to the unified system,and the classification of which evolved from the level classification of the binary system to the multi-latitude classification.The Japanese higher education classification includes both the horizontal classification and the vertical stratification.The higher education of our country takes the vertical level classification as its main frame,which is not conducive for the colleges to develop uniquely and with high quality in their places.


This paper exhibits a grounded meminductor emulator designed using an operational amplifier generalized impedance converter (GIC) and a memristor. One of the resistors of GIC has been judiciously replaced by memristor to convert active inductor circuit into meminductor emulator circuits. For the proposed grounded meminductor emulator, pinched hysteresis loops of up to 5kHz have been produced. The simulation findings were obtained using the LTspice simulation tool. The pinched hysteresis loops are shrinking when the frequency is varied from 100 Hz – 5 kHz. A high pass filter has also been constructed and simulated using the proposed meminductor emulator to validate its performance.


1)The results of an experiment to determine the effects of intrathecally administered streptomycin in a small group of non-meningitic patients are recorded. 2)Particular emphasis is placed on the evaluation of cerebrospinal fluid findings during and after cessation of therapy. 3)A group of 10 cases of tuberculous meningitis treated with streptomycin is reported in which one patient (10 per cent) was still alive and well 33.5 months after onset of therapy. 4)Some important factors which influence length of survival are:
 (a)duration of meningitis prior to onset of therapy. (b)presence or absence of associated intracranial tubercles or tuberculomata. (c)presence or absence of associated acute generalized miliary tuberculosis. (d)age of patient (child or adult). (e)adequacy of treatment. 5)A plan of treatment is outlined arid criteria for an apparent "cure" are suggested.