The article is devoted to defining an approach to studying the readiness to invest on the basis of blockchain technology in terms of new economic paradigm. The goal of the study is to develop a scientific approach to identify the attitude and level of confidence in investing in cryptocurrency among the population of the Russian Federation. Additional goals of the study are justification of the need to assess the internal factors of readiness of investing in cryptocurrency, as well as an analysis of the theory of reasoned action and perceived value. The main research methods are the systematization of the analysis of scientific and practical research, questioning, comparison and synthesis. The widespread distribution of blockchain technology can become a turning point in history; yet now, these technologies and the possibilities of their application are at the starting point of their development. The use of blockchain technologies can lead to a complete reconsideration of the ideas of money, trade and commerce. At the current stage of the development of cryptocurrencies and the technologies based on them, determining a scientific approach to the study of the attitude of the economically-active population to new investment instruments in the conditions of uncertainty cannot be grounded in classical methods that assess the willingness to invest in traditional instruments. The article proposes an approach to assessing the internal factors of readiness to invest in cryptocurrency based on the theory of reasoned action and perceived value.


Essentials An IgA paraprotein with anti‐thrombin activity was not associated with a severe bleeding phenotype. This observation challenges the paradigm that anticoagulant therapy necessarily increases bleeding risk. Characterization of the antibody showed that it specifically binds to thrombin exosite I. A therapeutic drug with the properties of this antibody might be an antithrombotic that doesn't cause bleeding.


The Mobile ad hoc network commonly known as MANET, is a collection of mobile wireless nodes that has the capacity to self-organize dynamically without any preexisting infrastructure. Scalability and network performance are the two distinctive feature found in all MANET routing protocols .The simulation compares AODV with Self Adaptive on Demand Geographic Routing Protocol(SOGR) implemented through NS2.With the help of performance metrics such as throughput ,Packet drop rate ,Control Overhead , Average delay ,Cost factor , latency it is shown that SOGR-HR and SOGR-VR gives better performance than AODV. The simulation results demonstrate that SOGR-HR and SOGRVR deliver high robustness in MANETs. These protocols can efficiently handle different dynamic scenarios and they offer high performance when compared to their existing geographic routing protocols under various environments. This paper presents an overall performance comparison on the basis of throughput ,Packet Delivery Ratio, Cost Factor and Average end-to-end delay considering different number of nodes and their mobility.


Infrared-alarm single chip microprocessor system was designed on basis of introducing the pyroelectric infrared sensor(PIS). Moreover, not only the structure of system and the working principle of the pyroelectric infrared were illustrated, but also the disposal method and software process flowchart were analyzed. This system is achieved by pyroelectric infrared sensor and intel8031 single chip microprocessor.


Restoring shortleaf pine throughout its native range in the Ozark Highlands is a high priority in Missouri. Restoring shortleaf pine on former pine and oak-pine sites is a longterm strategy for mitigating chronic oak decline (Law et al. 2004). Underplanting or preharvest planting is one method that has potential for restoring shortleaf pine.


ABSTRACT Choline transport is characterized by sodium-dependent high-affinity, sodium-independent low-affinity, and sodium-independent blood–brain barrier transport mechanisms. Each defined mechanism has specific characteristics with regard to affinity for choline, transport capacity, and inhibition by hemicholinium. The purpose of this study is to determine the characteristics of choline transport across Caco-2 monolayers. Methods. Choline transport across Caco-2 cell monolayers was determined in both the apical to basal direction and the opposite direction. Further, the determination of calcium dependence and specific inhibitors was made. Determination of the apparent permeability of choline was calculated by established methods. Results. The apical to basal Caco-2 permeability coefficient is 11.11 ± 0.33 × 10−6 cm/sec with 21.3% of the choline associating with the cells. Meanwhile the basal to apical value is approximately 50% less (5.55 ± 0.14 × 10−6 cm/sec), suggesting an active apical to basal transport mechanism. Choline transport in this system was inhibited by nifedipine (82%), verapamil (80%), EGTA (36%), and cyclosporin (15%). Conclusions. Choline transport across Caco-2 cells is demonstrated to be active and both pH- and Ca2+-dependent. Furthermore, choline transport across Caco-2 monolayers has unique characteristics when compared to traditional choline transport models.


The structure, function, characteristics and practice teaching subjects of an experimental base of simulation substation are introduced in this paper. In practice it is proved that the base is advanced in technology in China. And its functions of teaching, training and scientific research are perfect and comprehensive. The substation can be referred in the technology reformation of railway traction substation nowadays because of its newest long-distance monitor technology.


Leokadiya Kashperova's romantic compositions were highly regarded by Rimsky-Korsakov, César Cui, and by Balakirev whose works she premiered and recorded. In 1907, Kashperova performed her own compositions to critical acclaim in Leipzig, Berlin and London. After the 1917 Revolution following her death in 1940, her name joined her fine music in historical anonymity and oblivion. This Element is the result of twenty years' research culminating in eight study-visits by the author to St Petersburg, Moscow and the Yaroslavl/Kostroma region. The Biography (section 1) is the first ever written about this composer. Kashperova's Memoirs (section 2) and her Recollections of Anton Rubinstein (section 3) are made available in translation for the first time. Together with a new edition of her compositions (Boosey & Hawkes, London) this Element aims to support the restoration of Kashperova to her rightful place in music history as Russia's foremost female composer of the early twentieth century.


Red spruce seedlings (Picea rubens Sarg.) were exposed to charcoal-filtered air, at 0 .07 ppm or 0. 15 ppm ozone (0 3), alone or in combination with pH 4 .2 or pH 3.0 acidified rain, and examined with scanning electron microscopy (SEM) to determine if epistomatal wax fine structure was affected. Acidified rain in combination with 0 .15 ppm 0 3 produced changes in wax tubule morphology. Changes were moderate at pH 4.2 and severe at pH 3.0. Needles collected from Whiteface Mountain, New York, displayed injured epistomatal wax structure similar to that observed on needles exposed in the laboratory to 0 .15 ppm 0 3 plus pH 3.0 acidified rain.


INTRODUCTION
Attention deficit hyperactivity disorder is the most common
neurobehavioural disorder of the childhood. It is characterised by inattention,
hyperactivity and impulsivity. Neurological Soft Signs represent subtle
neurological signs that could not be localised to a particular region of brain.
Minor Physical Anomalies are subtle phenotypic abnormalities that don't fit
into dysmorphic syndromes. Both the NSS and MPA indicate a diffuse brain
injury. And both are present in many of psychiatric disorders and behavioural
disorders especially ADHD.
AIMS & OBJECTIVES
To study the Neurological Soft Signs and Minor Physical Anomalies in
ADHD siblings in comparison with age matched controls. To study the
correlations of Neurological Soft Signs and Minor Physical anomalies with
respect to gender and socioeconomic class of the children. To study the
interrelationship between various domains of soft signs with minor physical
Anomalies.
SUBJECTS AND METHODS
Study was conducted in child psychiatry department. Siblings of the
children diagnosed of ADHD during the study period, who doesn't have a
feature of neurological or psychiatric abnormality including ADHD, from 8 to
13 years were included in the case group. Normal children were included in the
control group. The number of children included in both case and control group
were 57. The children included in the study were given revised Physical and
Neurological Evaluation of Soft Signs (PANESS) and WALDROP Minor
Physical Anomaly Scale and scores were assessed.
STATISTICAL ANALYSIS
The scores of various domains of Neurological Soft Signs and Minor
Physical Anomalies were drawn. Independent t test were applied between the
two groups. P <0.05 were taken as significant. Similarly correlations were
drawn among gender and socioeconomic class with NSS/MPA by Pearson's
correlation. Statistical analysis were done by SPSS version 17.0.
RESULTS
Total number of children included in the study was 114. Of that 74 were
male and 40 were female. Socio economic class was obtained for each child by
modified kuppusamy scale. There is a statistical significance of p< 0.05 in
overflow items, gaits and stations, total timed and total PANESS. p> 0.05is
noted for minor physical anomalies for both case and control group. There is no
statistical difference for males and females for NSS/MPA separately for both
the case and control group. There is a positive correlation for overflow items &
timed movements with minor physical anomalies for ADHD siblings in lower
middle and upper lower socioeconomic groups.
CONCLUSION
ADHD siblings showed a significant increase in Neurological soft Signs
when compared with normal children. While ADHD siblings fail to show a
significant increase in Minor Physical Anomalies compared with Normal
children. The inter correlation of Minor Physical Anomalies with various
domains of soft signs showed positivity for overflow and timed movements,
especially for sibling group in lower middle and upper lower group. There is no
significant difference between males and females in both sibling group and
normal children in Neurological Soft Signs and Minor Physical Anomalies.


The research aims to demonstrate the effect of academic freedom in the promotion of social responsibility from the standpoint of teaching faculty members in Palestinian university of Gaza provinces. The researchers used descriptive analytical approach. The research community consists of the faculty members of (the and the study tool is a questionnaire applied on a stratified random sample of staff members, and (250) questionnaires were obtained with recovery rate of (84.75%). The results of the study showed a statistically significant relationship between academic freedom in all its dimensions (teaching, expression of opinion, scientific research, decision-making, community service) and the promotion of social responsibility dimensions (administrative and procedural, societal, ethical and moral, environmental health, national and affiliation, cognitive and educational) from the perspective of university teaching staff. Also it showed the presence of a statistically significant effect between academic freedoms (freedom of teaching, scientific research, community service) and the promotion of social responsibility, and the (freedom of expression, and freedom of decision-making) was a weak effect. The results also showed no statistically significant differences for both variables (educational qualification, and years of service) and that there are differences according to the variable of the university in favor of Al-Azhar University. The researchers recommended providing good regulatory environment for the exercise of academic freedom and promote innovation and support for faculty members and urged them to do diverse and creative scientific research and achievement of leadership, and encourage them to participate in conferences, seminars and express their opinions in complete freedom.


Near velocity-matched coplanar strip electrodes for high-speed BaTiO3 thin film electro-optic modulators are achieved. The velocity mismatch between optical wave and microwave is 2%. Microwave loss and impedance of the electrodes are measured.


An atom-economical and straightforward polymerization method to generate functional isocoumarin-containing polymers was developed in this work. The oxidative polycoupling of 4,4′-(1,2-diphenyl-1,2-ethenylene)dibenzoic acid and 1,6-bis[4-(phenylethynyl)phenoxy]hexane proceeds efficiently in dimethylformamide under nitrogen or air in the presence of [Cp*RhCl2]2 and a catalytic amount of Cu(OAc)2·H2O at 120 °C for 24 h, generating a polymer with a high molecular weight of up to 42 900 in a high yield of up to 92.9%. An isocoumarin framework forms in situ during the polymerization from readily accessible and inexpensive monomers. The resulting polymer possesses good thermal stability, optical transparency and film-forming ability. Its thin film exhibits high and UV-tunable refractive indices (n = 1.9697–1.6507) in a wide wavelength region of 390–890 nm. A two-dimensional fluorescent photopattern can be readily fabricated by irradiating its thin film under UV light through a copper mask. Due to the incorporation of tetraphenylethene units in the monomer, the polymer obtained is weakly emissive in solution but it emits intensely when aggregated, demonstrating a phenomenon of aggregation-induced emission.


has resulted in a substantial redistribution of municipal resources away from the capital and an increase in citizen participation. My only other criticism is the failure to include a conclusion at the end of this rich study. A concluding section could have pulled together the diverse country studies and linked them to the theoretical issues that are raised in the first section. Regardless, Nickson has written a very fine book.


This research is an empirical study with a survey of MSMEs in Banyumas Regency. The purpose of this study was to determine the condition of the structure of internal control of MSMEs, to know the development of MSMEs in Banyumas Regency, to know the significance of the influence of internal control structures, the quality of human resources, the completeness of MSME business records and management functions on the development of MSME businesses both simultaneously and partially. to find out the variables that most influence the business development of MSMEs. This study uses multiple regression analysis. Based on the results of the study, it was concluded that the structure of internal control in MSMEs in Banyumas District was adequate. There are developments in the business of MSMEs in Banyumas Regency from 2012 to 2016. Simultaneously the structure of internal control, quality of human resources, completeness of business records and management functions have a significant effect on the development of MSME businesses in Banyumas Regency. Partially the quality of human resources and completeness of business records documents have a significant effect on the development of MSME businesses in Banyumas Regency, while the internal control structure and management functions have no effect on the development of MSME businesses in Banyumas Regency. Quality of Human Resources is the most influential variable on the development of MSME business in Banyumas Regency.


It is a great honour and a pleasure to be invited to deliver the Kingsley Laffer Lecture this evening. As a graduate of the Faculty of Economics (now Economics and Business) at the University of Sydney it is also something of a homecoming. I am conscious of the prominence of earlier Laffer Lecturers. These include a former Prime Minister, a member of the High Court of Australia, ACTU Presidents and numerous other distinguished persons. As Chief Executive of the Australian Industry Group, I am also very pleased to be following in the footsteps of Bert Evans, one of my predecessors and a mentor, who delivered the Laffer Lecture in 1994. I well remember that lecture. It was something of a watershed for the Ai Group (then the Metal Trades Industry Association). It marked the final capitulation of our defence of Australia's centralised industrial relations system. The Ai Group had been a fervent supporter of this system. Our members had long experienced the damaging effects of wages leapfrogging and union campaigns for shorter hours and other improved conditions. The industrial harmony that prevailed during the accord years in the 1980s was a welcome respite. By mid-1994, the Ai Group's position on the shape of Australia's workplace relations system had shifted dramatically. It had shifted with the recognition that Australia and Australian industry had taken a new path of global integration where international competitiveness was the benchmark andwhen a 'uniquely Australian approach' to markets and their reform would be fundamentally challenged. Bert made the comment that 'things will never be the same again' and when I look back, he was clearly right. That speech also explored how viable and relevant the Australian concept of 'fairness' was to the conduct of industrial relations in Australia. This was juxtaposed against the challenge of trade being conducted not between countries of similar real wages and per capita GDP levels as had characterised the 1960s and 1970s, but between countries of very unequal cost and regulatory regimes.


In the Ming and Qing Dynasties,with the emigration of Fujian people to Taiwan,the religion and culture of Fujian gradually formed a religious tie,with Fujian ancestral temples as their roots,Taiwan mother temples as their branches and Taiwan descendant temples as their leaves.In order to maintain and strengthen this tie,Fujian and Taiwan kept in close touch with each other by means of their religion,which played a very important role in their mutual relationship.Since the implementation of the policy of reform and opento-out,the relationship between Fujian and Taiwan has become closer and a large number of followers have come to Fujian to pay homage to their ancestors in the ancestral temples,thus promoting the economic development of Fujian objectively,sublimating their identification with the traditional Chinese culture and promoting the development of the political relationship between Fujian and Taiwan.


Recent interest in the finiteness problem of the vacuum energy density (VED) in finite QED has motivated us to reexamine this problem in the light of an analysis we have carried out earlier. By a loopwise summation procedure, supplemented by a renormalization-group analysis, we study the finiteness of the VED with $\ensuremath{\alpha}$, the renormalized fine-structure constant, fixed in the process as the (infinite order) zero of the eigenvalue condition ${{F}^{[1]}(x)|}_{x=\ensuremath{\alpha}}={0}^{\ensuremath{\infty}}$, and with the electron mass totally dynamical of origin. We propose a possible finite solution for the VED in QED which may require only one additional eigenvalue condition for $\ensuremath{\alpha}$.


Coleus aromaticus Benth. is a drug which is being used by some folklore practitioners for the diseases like fever, cough and ur o - genital disorders. The drug, Coleus aromaticus Benth. which is widely available in India, which is often discussed as a controversy for the s ource of Pashanabheda. The above mentioned drug is having Kaphavatahara property. Clinical trials were done on 40 patients, assigned in 2 groups of 20 each. The patients were treated with Ambrodil syrup a nd Arka of Coleus aromaticus Benth. in Group A and Group B respectively. The duration of the treatment was 10 days. Patients were assessed on 5 th , 10 th day and a follow up was of 20 day s . The effects of treatment w ere assessed statistically on the basis of gradation of cardinal signs and symptoms, before and after treatment. The results were analysed statistically. The analysis suggested that The Coleus aromaticus Bent h. is a good choice of drug in Kaphajakasa (productive cough) associated with Aruchi (Anor exia) , and number of cough bouts .


[Objective] The study was to find the rooting medium suitable for tube seedling of Cannabis Sativa.[Method] With tube seedling of C.sativa as the tested material,the treatments of different hormone combinations,basic medium,sucrose concn.and pH value were set up.The number of rooting,axillary bud number,stem thickness and root length of the tube seedling in different treatments were made for statistic and the induction rate of root was calculated.[Result] The average rooting number of tube seedling in treatments with 0.1 mg/L IBA and 0.05 mg/L NAA were the most,reaching 2.45 trips/plant and that in treatments with 0.5 mg/L IBA and 0.05 mg/L NAA were the least,and that in treatments with 1/2 MS and MS basic medium were more,being 2.05,2.45 strips/plant resp.The average rooting number and the induction rate of root of tube seedling in treatments with 30 mg/L sucrose was significantly higher than that in other treatments,being 2.25 strips /plant and 80.0% resp.,and that in treatments with pH 5.8 was the biggest,being 2.35 strips /plant and 75.0% resp.[Conclusion] The optimal rooting medium for tube seedling of C.sativa was 1/2 MS+0.1 mg/L IBA+0.05 mg/L NAA+30 mg/L sucrose with pH 5.8.


Background: Patients with oncohematological malignancies have been excluded from the clinical trials in which the vaccines against COVID-19 were approved. Although there are some studies that have evaluated the immunologic


The present paper combined the natural environment excitation technology (NExT) with the eigen system realization algorithm (ERA) to identify the modal parameters of a suspension bridge. Firstly, the critical parameters in NExt–ERA, such as record length, window length, and ranks of the Hankel matrix, and their influence on identification accuracy have been discussed. Subsequently, based on the acceleration series obtained from the Xihoumen Bridge Health Monitoring System, 3015 sets of modal frequencies and modal damping ratios of the Xihoumen Bridge were identified under 7 sets of wind speeds by the NExt–ERA. Finally, the probability distribution and confidence interval of the structural modal damping ratios were analyzed. Besides, the dependence of identified frequencies damping ratios on wind speed was also discussed. The results show that at the same wind speed, the mean value, and variance of the torsional and lateral mode damping ratios are larger than those of the vertical mode, but this difference gradually decreases with the increment of wind speed. The modal damping ratios along three directions under different wind speeds all follow the generalized extreme value distribution, but wind speed affects the tailing properties of probability distribution of the vertical and torsional mode damping ratios. The estimated damping ratios could provide references for structural design and vibration control of similar long-span bridges.


Abstract Objectives: There were two study objectives: (1) to determine the diagnostic accuracy of hysteroscopy in women with abnormal uterine bleeding (AUB) and (2) to correlate hysteroscopic and histopathologic findings in patients who had AUB. Materials and Methods: This prospective longitudinal study was conducted at the Dr. D.Y. Patil Medical College, Hospital & Research Centre, in Pimpri, Pune, India, from April 2015 to November 2016. The study included 60 patients who came to the outpatient department with complaints of AUB. The patients were admitted 1 day before the procedure, after they each signed informed consent forms for participation in the study. The patients did not require anesthesia; a 2.9-mm hysteroscope was used, with normal saline as the distending media. Results were recorded on a prescribed proforma. The patients then underwent dilatation and curettage and the endometrial sample tissues were sent for histopathologic examination. The correlation between findings on hysteroscopy and h...


Clinical Risk does not have a letters page, chiefly because it is only published in alternate months and therefore the cut and thrust of comment and riposte cannot be achieved. Sometimes, however, response to criticism is necessary and I have therefore used the opportunity offered by this column to reply to remarks about the NHSLA by one of the AvMA panel members in the January issue. Two replies to AvMA contributions in successive columns might be perceived as a major falling out. That is definitely not the case. NHSLA and AvMA continue to have cordial relations, but in the world of litigation it is inevitable that there will be significant disagreements from time to time. Indeed, every claim which reaches a contested hearing will have seen lawyers on both sides advising that their case is good and that it is worth putting matters before a judge. John Mead


We present methods and preliminary results of a relatively novel search for nearby stars. The method relies on photometric distance estimates as its primary search criterion, thus distinguishing itself from proper motion-based searches that have produced the bulk of nearby star discoveries.


The development of the OSCAR program (OTEC Steady-state and Control System Analysis Routines) to perform dynamic simulations for arbitrarily configured OTEC plants is described. The design goals for OSCAR are presented, and details about the initial plant equipment models are given. These models have two features: relative simplicity but with enough complexity to permit adequate simulation over a wide range of operating conditions. The most significant new work on modeling is for evaporators and condensers, and these results are given in detail. One unit model is not yet included, the turbine model. After presenting the models in some detail, the design details established to date for OSCAR are presented. These details show the expected structure of OSCAR and indicate what each part is to do. The design is not yet frozen. The approach represents the next generation of several earlier and existing efforts at designing and implementing simulation systems. As such it has features which generalize many features of earlier designs to make the system easier to implement and use while still giving greater flexibility in use. The appendix presents the more detailed aspects of the evaporator and condenser modeling.


This is the first in a series of reviews of the role of the pulmonary physician in critical care medicine. The investigation of mechanically ventilated patients is discussed, with particular reference to those presenting with acute respiratory failure and diffuse pulmonary infiltrates.


Analyzing Role Based Access Control(RBAC) Model,a new extended role_based access control model is developed.The concept and implementation principle of access control are introduced and characteristics of RBAC are analyzed.The application of the extended role_based access control under the struts framework are also described in details with its application exemplified.Compared to conventional access control model,the application of the extended role_based access control model under struts framework reduces the complexity of authorization management,realizes decentralized administration,reduces expenses and supports the security tactics of port in more flexible way


Changes in resistivity and chemical changes in reducing gases were measured for porous zinc oxide ceramics with and without a platinum catalyst at 300° and 400°C to examine the gas sensing mechanism and the effect of platinum additions. Reducing gases were oxidized to CO2 and Hz2 on the sensor surfaces. Platinum addition promoted the oxidation of reducing gases but did not lead to an increase in the resistivity change at 400°C. The reaction sequences for the gas sensing process are proposed, taking into account partially oxidized intermediates of hydrocarbons and oxidation on platinum without an electron transfer process.


: Background - Takotsubo cardiomyopathy is an acute heart failure syndrome characterized by myocardial hypocontractility from the mid left ventricle to apex. It is precipitated by extreme stress and can be triggered by intravenous catecholamine administration, particularly epinephrine. Despite its grave presentation, Takotsubo cardiomyopathy is rapidly reversible with generally good prognosis. We hypothesised that this represents switching of epinephrine signalling through the pleiotropic (cid:69) 2 -adrenoceptor ( (cid:69) 2 AR) from canonical Gs-activated cardiostimulant to Gi-activated cardiodepressant pathways. Methods and Results - We describe an in vivo rat model in which a high intravenous epinephrine, but not norepinephrine, bolus produces the characteristic reversible apical depression of myocardial contraction coupled with basal hypercontractility. The effect is prevented via Gi inactivation by pertussis toxin pretreatment. (cid:69) 2 AR number and functional responses were greater in isolated apical cardiomyocytes compared to basal cardiomyocytes, confirming higher apical sensitivity and response to circulating epinephrine. In vitro studies demonstrated high dose epinephrine can induce direct cardiomyocyte cardiodepression and cardioprotection in a (cid:69) 2 AR-Gi dependent manner. Preventing epinephrine-Gi effects increased mortality in the Takotsubo model, while (cid:533) -blockers which activate (cid:69) 2 AR-Gi exacerbated the epinephrine-dependent negative inotropic effects without further deaths. In contrast levosimendan rescued the acute cardiac dysfunction without increased mortality. Conclusions - We suggest that biased agonism of epinephrine for (cid:69) 2 AR-Gs at low and Gi at high concentrations underpins the acute apical cardiodepression observed in Takotsubo cardiomyopathy, with an apical-basal gradient in (cid:69) 2 ARs explaining the differential regional responses. We suggest this epinephrine-specific (cid:69) 2 AR-Gi signalling may have evolved as a cardioprotective strategy to limit catecholamine-induced myocardial toxicity during acute stress. Myocytes the 30 Isolated rat cardiomyocytes were plated in culture medium at a field density of 10,000 cells/well and infected with either Ad. (cid:69) 2 AR.GFP, (cid:69) 2 AR with mutations at the PKA phosphorylation sites 261, 262, 345, 346 S/A ( (cid:69) 2 AR-PKA-KO) (Ad. (cid:533) 2 AR-PKA-KO) or Ad.GFP (control) at a multiplicity of infection (MOI) of 500 for 48 hours. For pertussis toxin (PTX) treatment, Ad. (cid:69) 2 AR.GFP infected rat ventricular myocytes were cultured in the presence absence of PTX (1.5 μ g/ml) for 48 hours. Survival in culture was shown as a percentage of rod-shaped myocytes at the time of plating: >100 cells per well were counted, with triplicates for each condition. (cid:69) 2 AR-specific contractile responses were measured on separately isolated apical and basal ventricular cardiomyocytes using isoproterenol (100nM) plus the (cid:69) 1 AR selective antagonist CGP20712A 21, stroongng eevividedeencnccee fofofor r a a GiGiGi-d-d-depeppeenndentnt mecchhhaniiismsmsm ooof acacttiioonn. AAApiicaall l aanand d mmimid-d-dLVLVLV wwitititchchhededed cccomomomplpleeetelelelyyy totto gggivive anana iiincncncrrereasasse e ininin ccconnntrtrtaacactitiiononn, , ananandd d evevvenenn bbbasasasalall hhyypypererrcocoontntntrararacctctililliiity y y wawaas ignificantlyyy enenenhahahancncncededed.. PTPTTX X X prprpetetetrereratatatmemementntnt dddididid nnnototot alalateteter bababaseseselililinenene fffununnctctctioioion,n,n, ttthhhe e sysysystststemememicicic arterial


The problem of political discourse appeared as a reaction to the need for generalization, or as an attempt to find common points in the vast variety of political research. This task was set by Foucault when he wrote "The Archaeology of Knowledge", for disciplines "whose boundaries are very blurred, and the content is extremely vague - in the history of ideas, science, thought or knowledge".
Political discourse, apart from the obvious at first glance, the positive results for the study of political phenomena - the possibility of mutual use of different methodological approaches to maximize research of related Sciences (psychology, sociology, linguistics), providing the possibility of determining the object of study, it also raised a lot of issues to be addressed: in particular, the problem of deducing from-under charges of excessive bias in linguistic research, issues, media, politic, problems of structure and form.


This study evaluates the effectiveness of transfer learning models in industrial surface defect detection using few-shot learning. Surface defect detection is a critical task in various industrial applications, where accurately detecting and classifying defects can improve product quality and increase manufacturing efficiency. However, data scarcity is a considerable challenge: obtaining and labelling defect samples is a costly, time-consuming process and difficult due to their infrequent occurrence. Few-Shot learning aims to effectively train models using only a limited number of labelled samples, thus mitigating the impact of data scarcity. This study compares the performance of transfer learning models pre-trained on three different data sets for few-shot learning in the context of surface defect detection. On the one hand, transfer learning models pre-trained on the ImageNet data set yield the best overall results in terms of accuracy. On the other hand, our results indicate that the DAGM data set, an industrial optical inspection data set which is close to the target domain, is particularly effective for training models to clearly detect surface defects in a few-shot learning scenario.


The oxidation of lipid and Metmyoglobin of yellow fin tuna fish in different storage temperatures were researched using kinetics models of the reactions with respect to the storage time and storage temperature. The oxidation of lipid and metmyoglobin increased with prolonging the storage time and increasing the storage temperatures. The zero-grade reaction and Arrhenius equation were used to describe the relationship between the oxidation of lipid and metmyoglobin with the storage time and temperature. The calculated data from the presented model were well consistent with the experimental results.


The main purpose of this study is to investigate the relationship between Writing feedback orientation (WFO) and self-regulated learning (SRL) Writing L2 strategies in online teaching during COVID-19. 200 EFL students from Van Lang University in Vietnam were recruited to participate in this study from a variety of courses (98 first-year students and 102 second-year students), using the questions from Jian Xu's study as a guide (2021). Data from this study are examined using qualitative, quantitative, and theoretical studies methodologies. Evidence from experiments has been gathered and categorized a number of guidelines that students follow when exercising in writing with a focus on feedback and self-controlled learning Writing techniques to develop their writing abilities. The findings revealed that EFL students had developed an optimistic response toward written corrective feedback (WCF), which is related to SRL strategies; at the same time, the teachers' and students' online interactions are also associated with teachers' feedback, which has created a confident academic online space for students accomplishing further tasks during COVID-19.


Seismic monitoring and 4D seismic have been very successful in the clastic reservoirs of the North Sea and the Norwegian sea during the last 10-15 years. The Njord field in the Norwegian sea is a difficult 4D case since results are counterintuitive: a relatively large interval velocity decrease is found in a location where it was thought that the pore pressure had decreased. The understanding of the data has recently improved, by constructing a simple pressure model that puts more weight on overpressure due to gas injection, and little weight on pressure depletion. A proper petro-elastic model was constructed, taking into account both saturation effects and pressure effects. The most important contribution to the new understanding was to study the correlation between the injection history and the 4D seismic response in 3 monitor surveys close to the injection wells. The new understanding of the data allows for a more reliable prediction of future 4D response, and may be important for the future development of the Njord field.


As the quality of ideology is the most important one in the process of quality education, we must reform the teaching of ideology and Marxism to improve students′ ideological quality. To educate qualified personnel, we need pay more attention to the following factors:leaders′ care, teachers′ exploration of new teaching methods, implementation of modern teaching media, a good class teaching and social practice and rennovation of concerned examinations.


Nanofibers as elements for bioscaffolds are pushing the development of tissue engineering. In this study, tussah silk was mechanically disintegrated into nanofibers dispersed in aqueous solution which was cast to generate tussah silk fibroin (TSF) nanofiber mats. The effect of treatment time on the morphology, structure, and mechanical properties of nanofiber mats was examined. SEM indicated decreasing diameter of the nanofiber with shearing time, and the diameter of the nanofiber was 139.7 nm after 30 min treatment. These nanofiber mats exhibited excellent mechanical properties; the breaking strength increased from 26.31 to 72.68 MPa with the decrease of fiber diameter from 196.5 to 139.7 nm. The particulate debris was observed on protease XIV degraded nanofiber mats, and the weight loss was greater than 10% after 30 days in vitro degradation. The cell compatibility experiment confirmed adhesion and spreading of NIH-3T3 cells and enhanced cell proliferation on TSF nanofiber mats compared to that on Bombyx mori silk nanofiber mats. In conclusion, results indicate that TSF nanofiber mats prepared in this study are mechanically robust, slow biodegradable, and biocompatible materials, and have promising application in regenerative medicine.


BACKGROUND
Foot orthoses are widely used in conservative treatment of painful flexible flatfoot (PFFF) however research is limited to choose the best option in orthotic treatment.

AIM
We aimed to compare the effects of computer-aided design/computer-aided manufacturing (CAD-CAM) and conventional insole types in comparison with sham insole, on pain and health related quality of life in patients with PFFF.

DESIGN
Randomized controlled trial.

SETTING
Outpatient rehabilitation clinic.

POPULATION
Sixty-seven people with PFFF, aged between 18 and 45 years, were assigned to CAD-CAM (N.=22), conventional (N.=22) or sham (N.=23) groups.

METHODS
In addition to insoles, a home-based exercise program was followed by all participants for eight weeks. Foot pain intensity and quality of life were assessed at the initial evaluation and at the end of two-month follow-up.

RESULTS
Pain intensity (Mean±SD, mm on VAS) was significantly lower in CAD-CAM (27.84±18.41) and conventional (27.05±16.82) insole groups than sham group (46.39±20.18) after two months (P<0.05), but there was no difference between conventional and CAD-CAM (P>0.05). All groups had significantly higher physical health scores at the second assessment (P<0.05), but there was no intergroup difference (P>0.05).

CONCLUSIONS
CAD-CAM and conventionally designed insoles are both more effective than having sham insole in alleviating pain in PFFF.

CLINICAL REHABILITATION IMPACT
CAD-CAM and conventionally designed semicustom insoles in conjunction with a home-based exercise program are both effective in controlling pain compared with sham insole and exercise in PFFF. Clinicians can prescribe both types of semicustom insoles as a part of conservative treatment instead of each other.


In this paper, we study the power allocation in Orthogonal Frequency Division Multiplexing (OFDM)-based Cognitive Radio (CR) networks with cooperative relay. Since the energy consumption is growing at a staggering rate, green radio, which puts emphasis on the energy-efficiency (EE) in wireless networks, is becoming increasingly important. Therefore, we try to maximize the EE of a relaying CR system, under the consideration of many practical limitations, such as transmission power budget, interference threshold of the primary users and the traffic demand. We first convert the formulated problem into a convex optimization one via its hypogragh form, which can be solved by the barrier method. By exploiting the special structure of the formulated convex optimization problem, we further speed up the computation of Newton step during the barrier method, significantly reducing the complexity of the algorithm. Numerical results validate that our proposal can exploit the overall EE of the CR system, while the algorithm converges efficiently and stably.


The variant management funnel proposed in this work is a method to sort out, evaluate, and improve concepts for new modules and module variants in the market phase of an existing modular product family. Although modular product families are broadly applied in industry today, they are generally not properly managed in their market phase. The key properties of a modular product family, namely its product structure and interfaces, are not safeguarded. Numerous additional modules and module variants are introduced in the market phase of the product family. Many of these new modules and module variants are very expensive in following phases of the innovation process, e.g. development or manufacturing. That is why in the variant management funnel, concepts for new modules and module variants have to pass two screens. • Compatibility screen: It is checked if the concepts are compatible with the existing modular product family in terms of product structure and interfaces. This is done with the help of two tools. The framework for modular product families is a tool to capture the product structure of a modular product family using UML. Module sheets are a tool to capture interfaces and related information for all modules. All concepts that do not pass the compatibility screen are either discarded or reworked. • Stakeholder screen: The remaining concepts are evaluated and improved by means of the effects they have on various stakeholders within the corporation. The probabilistic evaluation and improvement tool allows the decision maker to model these effects using probability distributions of decision criteria such as cash flow and amount of work. Depending on the properties of a concept, the resulting effects will look different. Concepts are therefore characterized by a set of properties. Concepts are evaluated and improved by calculating expected value and risk of the decision criteria for the respective set of properties. The calculation is facilitated by an Excelbased VBA application. The variant management funnel was developed and applied in the scope of an applied research project with industry. Two case examples describing implementation and use at the industrial companies are provided.


In a variety of renal disorders, including SLE and transplantation, in vivo platelet activation is present. This is in part a result of the nephrotic syndrome, but is also observed in patients with g.n. who are not nephrotic. As a result, intraplatelet concentrations of serotonin and other amines are depleted in patients with active nephritis. The functional capacity of such amine-depleted platelets has been little studied; Pareti et al (1980) reported defective aggregation to ADP, adrenaline and collagen in such "acquired storage pool deficiencies". We studied aggregation thresholds to ADP, collagen and AA in 25 patients with SLE nephritis, none of whom had a nephrotic syndrome or reduced renal function. In these patients platelet activation is due principally to circulating factors. Sixteen transplant recipients were also studied. In them, activation is principally within the renal microvasculature of the allograft. We also measured intraplatelet serotonin concentrations, which were low or zero in the great majority of patients in both groups. Bleeding times were normal in all, as were platelet aggregation thresholds to ADP and collagen. AA thresholds, however, were markedly depressed (<0.32 mmol) in all transplant recipients and most patients with SLE. This specific hyperaggregability may be responsible for both persistence of disease and the thrombotic tendency observed in some patients, including those with circulating anticoagulant.


The invention relates to a bacillus thuringiensis cry1Ca gene, expressed protein and application of the bacillus thuringiensis cry1Ca gene and belongs to the technical field of biological prevention and control. Insecticidal protein has amino acid sequence shown as SEQ ID NO.2. In a gene for encoding the insecticidal protein, preferably, the nucleotide sequence of the gene is shown as SEQ ID NO.1. The gene has high toxicity on lepidoptera pests and is applied to transformation of microorganisms and plants, so that the microorganisms and the plants have toxicity on the related pests, and drug resistance of the pests on engineering bacteria and transgenic plants is overcome and delayed.


Discloses a process for rearranging the resource coordination component in a local set of low power nodes (the LPN) a. The method may comprise the local resource FIG resource component macro node receives from a neighboring macro node neighboring physical resource blanking macro node and arrangements of components resources. Local macro node may be grouped together in a local coordinator and at least one set of low power node (LPN). Neighboring macro node may be grouped with at least one coordination within the LPN in the adjacent set. Neighboring macro node may be coordinated within the set is different from the adjacent local coordinate set. Local macro node may be used at FIG resource blanking adjacent macro node resource components in the same frequency domain index and the same time domain index is re-arranged for LPN local cell edge resource coordination component collection .


In 2012, a study on selective exposure to pornographic information via the internet among Jakarta adolescents was carried out in a model. The results showed that based on the theoretical model tested, it was found that the information usefulness variable had a more substantial influence than the group support and belief variables on selective exposure, and belief variable is the weakest. The results of this theoretical model research that has been carried out among adolescents in DKI Jakarta raise the question of what if the testing of this theoretical model is carried out among pesantren adolescents. This research is an exciting study considering that pesantren's parenting style model is subjected to the pesantren's caregiver. Hypothesis testing is done by using multivariate analysis techniques. The sampling method used was random cluster sampling. The research results related to the selective exposure model of pornography via the internet among pesantren adolescents conducted in Tangerang city show that group support dramatically influences the choice of direct pornographic information. Male respondents stated that pornography has information uses, and vice versa for female respondents. Respondents are classified as sensitive to pornography and have opposing beliefs. Furthermore, the study results indicated that there was an interest in pornographic information related to sex education, but this information did not have the effect of being an indication of sexual activity.


A familial decrease in activity in plasma protease inhibitor, Antithrombin III (AT III «as observed in three generations. This autosomal trait is not associated with thrombsis. It is a benign abnormality despite AT III functional values of 23% of normal in heparin co-factor assay. The low activity AT III was purified from fresh plasma on a heparm affinity column. Its functional, biochemical and immunochemical properties were studied. In the progressive AT III assay, both proteins behaved similarly. Binding of low activity I125 AT III to α1, thrombin or heparin column was identical Purified and plasma AT III from normal and propositus had the same electrophoretic mobilit on Polyacrylamide gel and by Immunoelectrophoresis (IEP) in 1.5K agar gelsHowever plasma and purified low activity AT III when analyzed by two dimensional (IEP) with heparin placed in the first gel showed one major immunoprecipltate and a much smaller more electronegative one against AT III antiserum. Under identical conditions, purifi normal AT III showed a reversed pattern. On electrofocusing and by immunodiffusion against antiserum to thrombin, the major immunoprecipltate was identified as an AT III thrombin comply. A variant of the propositus' AT III favors rapid binding of thrombi without need of heparin.


A general, green chemistry approach is developed for the immobilization of inorganic catalysts in monolithic porous flow-reactors for continuous flow reactions, in which pyrogallol (PG) acts as an assistant layer for the in situ immobilization of various catalysts on the inner pore surface of the flow-reactor. Au nanoparticles (AuNPs), Al2O3, and phosphotungstic acid (HPW) are selected as examples of noble metals, metal oxides, and polyoxometalate (POM) type catalysts, respectively, and the corresponding flow-reactors show high catalytic performance in continuous flow hydrogenation reactions, esterification reactions, and Knoevenagel reactions, respectively. These reactions are important in the treatment of environmental contaminants and in the chemical industry. In addition, multiple monolithic flow-reactors can be assembled together for efficient performance of multi-step cascade reactions.


An n‐type WO3 thin film on a p‐type GaAs substrate has been investigated in terms of its structural, electrical, and photocurrent–voltage characteristics. Crystallization of the monoclinic phases of WO3 occurred at 400 °C as identified by a glancing angle x‐ray diffractometer. Above 400 °C, small traces of gallium oxide (Ga2O3)were observed along with higher intensities of the monoclinic peaks. The formation of Ga2O3 was confirmed by a depth profile analysis using an Auger electron spectrometer. Electrical resistivity measured by the van der Pauw method was influenced by the crystalline nature and the interfacial states induced by the diffused atoms from each side of WO3 and GaAs. A high photocurrent density of 7.5 mA/ cm2 at −1.0 V (vs SCE) appeared at the crystalline WO3 on p‐type GaAs at 400 °C resulting from effective carrier movement through the interfaces.


But how far was practice in poetry consistent with this professed aim? Various facts must raise doubts as to whether classical learning was supplanted in any really thoroughgoing way. For to begin with, the new "divine" poetry often adopted the stock devices of Greek and Latin poetry, thus pouring Biblical story into moulds preshaped by neoclassical taste. Many of the Latin dramas on Biblical themes are Senecan in tone. Grimald's play on John the Baptist, for example, has a Nuntius-like Syrian girl report the beheading to John's disciples "with Senecan relish" (to use Miss Campbell's own phrase). Or again, the David of Peele's play responds to Bathsheba in a way clearly borrowed from Ovid. Both Grimald and Peele, moreover, did not hesitate to write other plays on classical themes—a Troilus, and an Arraignement of Paris. And the puritan Golding was a translator not only of Beza's Abraham Sacrifiant but also of Ovid's Metamorphoses. Such evidence does not suggest an aversion to pagan lore.


Looking back on the composer's creative journey and work in this year of his death, we are interested in his internal development and, along with this, his artistic identity. His identity took shape in a special relation to sound, that is, its abstraction – from this comes his predominantly instrumental opus and, with it, his fundamental relation to the world. As a student of Slavko Osterc until the second world war, Ramovs received the spirit of Osterc' avant-garde practices from the thirties and Ramovs was the first to continue these practices during the critical period of the sixties. He, however, identified his mentor as a neoclassical composer even though Osterc was again oriented towards Expressionism from 1934 on; such an orientation was also true of the creative works from Ramovs' first period, even still after his studies with Alfredo Casella during the war. This post war neoclassicism was not without influence from socialist realism with its obligatory optimism. This ideological climate most likely caused a slowing down of the composer's development. Such was true during the fifties, when in the course of a long process Ramovs felt the need to redirect himself away from an objective and towards a subjective expression until, with the attained expressionism at the beginning of the sixties, he went through a serial phase including its total organization. His attendance at the »Warsaw Autumn« in 1960 showed him the way forward into the world of aleatory, into a free but controlled improvised form, into free atonality, and into the free use of dodecaphony with »telling« cores of semitone steps. Thus in 1963, he took on the posture of an extreme narrator of subjective modernism, based on continuous contrasts, and characteristic dramatics and upheavals. In this most important third creative period, he continued varying and reconstructing his musical material in more than 400 opuses. His feeling of the world was extremely spiritualized, disharmonic, and based on pure sound, which is the essence of his aesthetics, the indirect expression of a composer's mental and spiritual world. Pure and ascetic sound enabled him a pure musical development, musical narrativity, and later still with a fullness of sound fields. On the mentioned level of sound, he also reacted in a concerned and intense manner; thus, he felt the threat of the extinction of the human race at the coming of the atomic era (Simfonija 68) and he acted as a dedicated nation-conscious composer (in works dedicated to the attainment of Slovenian national independence in 1991 – Per aspera ad astra [1991] or those in remembrance of the victims of the communist holocaust in Slovenia – Simfonija Pieta [1993]). Ramovs' avant-garde breakthrough in the sixties, when a group of younger composers called Pro musica viva quickly joined him, completes itself in the following three decades in a pronounced modernism, both intensified as well as moderated, which nevertheless do not open the question of postmodernism. With his artistic posture and achievements, he thus remains one of the most important composers of the entire second half of the twentieth century in Slovenia and an artist of international renown.


A model developed for the inelastic buckling of beams under uniform moment, which accounts for strain-hardening residual stresses and monosymmetry of the yielded cross section, is extended to the case of moment gradient by allowing for the effects of nonuniform yielding. A tangent modulus theory of buckling is used, and the governing differential equations are adopted from those which govern the elastic flexural-torsional buckling of tapered monosymmetric I-beams of constant depth. The critical central concentrated loads of simply supported I-beams are obtained by solving the governing differential equations numerically by using the method of finite integrals in an iterative process. The influence of the residual stresses, height of point of application of the load, and in-plane moment distribution on inelastic buckling are investigated, and the theoretical solutions are compared with design rules.


The presolar grains found in meteorites survived potentially destructive processes in the protosolar environment: the radiation field of the collapsing protosolar envelope; the protoplanetary disk formed by the collapse, known as the solar nebula; and the accretion shock through which material passed from the envelope to the disk. Theoretical models of these regimes, combined with experimentally determined destruction criteria, can be used, in principle, to put constraints on the physical conditions that prevailed prior to and during the formation of meteorite parent bodies. Preliminary studies, in which interstellar species are assumed to be destroyed at well-defined, critical temperatures, indicate that refractory species (e.g., silicates) survived envelope and shock to enter the nebula at or within about 1 AU of the Sun; volatile species such as water ice and simple organics retained interstellar characteristics only beyond several AU, the destruction distances being dependent on the protosolar accreti...


The Australian Government's guarantee of funds lodged with deposit-taking entities in Australia, and of security issues by Australian banks, has fostered support for smaller and less well-placed financial entities compared to the four major Australian banks. In applying in these settings there is a prospect of moral hazard in the benefited entities. With respect to the issue guarantee, there are grounds for expecting the prudential authorities to take steps to ensure that the funding support is not dissipated in fostering more risky asset portfolios.


According to the label accompanying the shells, they were found in sinking a Government well in the Murray River Flats, on the road from the Burra-Burra Mines to the Great Bend of the Murray River, about half way (thirty miles) between the two points named. For the determination of the Foraminifera I am much indebted to Mr. H. B. Brady, F.E.S., and to Prof. G. S. Brady, for a like examination of the Ostracoda. The Foraminifera are— Potystomella craticulata, F. & M. " macella, F. & M. Pulvinulina elegans, D'Orb. Quinqueloculina agglutinans, D'Orb. " secans, D'Orb. " seminulum, Linn, (var.) " subrotundn, Montagu. Rotalia Soldanii, D'Orb. Spiroloculina canaliculata, D'Orb. Triloeulina oblonga, Montg. ,, tricarinata, D'Orb. Truncatulina lobatula, W. & J. Biloeulina contraria, D'Orb. " depressa, D'Orb. " elongata, D'Orb. ,, ringens, Lamk. Cornuspira foliacea, Phil. ,, involvens, Reuss. Cristellaria rotulata, Lamk. Glandulina Icevigata, D'Orb. Sauerina cotnpressa, D'Orb. Orbitolites complanatus, Lamk. Planorbulina reticulata, Czjzck. " TJngeriana, D'Orb. The Ostracoda are—. Bairdia ovata, G. Brady. I Cythere Normani, G. Brady. Macrocypris acuminata, Reuss. | Paracypris decora, G. Brady. Prof. Brady remarks that these appear to be perfectly identical with the Ostracodal fauna now living in the seas of Australia and the Malay Archipelago. A few other Ostracoda were also present, probably new; but from the paucity of individuals it was scarcely advisable to describe them at present. The Murray Eiver Flats consist of a flat scrubby plain extendiug from the Murray Eiver on the East, between the Great Bend and Lake Victoria, to the South Australian Chain, or Cape Jervis Range, on the West, and must be composed of strata, geologically speaking, of no great antiquity; in fact, the whole of that portion of the southern coast of Australia bears evident traces of recent upheaval, even in places now going on. E. ETHERIDGE, Jun.


Objectives: 1. Describe some clinical epidemiological characteristics of Shigella dysentery in children in the Department of Gastroenterology of Central Children's Hospital in 2019; 2. Comment on treatment results in the above patients. Subjects: All patients under 15 years old are admitted to the Hospital of Gastroenterology, Vietnam National Children's Hospital.. Method of cross-sectional description. Results: More morbidity rates in men than in women. The male / female ratio is 1.8 / 1. In which, the highest incidence is from 1 to 3 years old. In comparison with other seasons, autumn has the highest proportion of hospital patients, accounting for 46.4%. The majority of patients admitted to hospital due to diarrhea and fever accompanied by blood in the stool accounted for 41.3%, some came to the hospital due to high fever with 15/184 patients accounting for 7.9%, high fever. Accompanied by seizures, accounting for 16.5%. The rate of treatment with Ciprofloxacin is 89.5%. The recovery rate is quite high, 93.3%, the percentage of patients who are also significantly better at 6.7% and there is no case of treatment failure.


This article establishes a dialogue between Virginie Despentes's 2006 memoir-cum-manifesto, King Kong théorie and Jack Halberstam's theorization of 'shadow feminism'. For Halberstam, 'not succeeding at womanhood can offer unexpected pleasures (…) Shadow feminisms take the form not of becoming, being, and doing but of shady, murky modes of undoing, un-becoming, and violating'. In King Kong théorie, I argue, Despentes embraces her failure to 'become woman', and her accounts of rape and rape fantasy present a refusal of mastery wherein the subject might unravel, come undone. Through her use of the King Kong metaphor, Despentes connects 'unbecoming woman' to an unravelling of the human subject; King Kong figures in the text as a composite, cyborgian creature, with whom Despentes herself identifies. In King Kong théorie, then, Despentes adopts a shadowy, hybrid positionality, forging a textual space for all creatures who fail to be or become woman.


Objective To investigate the effect of a soybean extract(CKBN) on immune function in immunosuppressed mice.Methods Immunosuppressed mice were induceded by intraperitoneal injection of cyclophosphamide(CTX).The effect of CKBN treatment at a dose of 1 mg/kg,25 mg/kg,50 mg/kg,and 100 mg/kg on the immune function in CTX-induced immunosuppressed mice was studied.Results The spleen index was significantly increased in the group of mice treated with 25 mg/kg CKBN,respectively.The inhibitory effect of CTX on the peripheral leucocyte count was reversed by the treatment of 25 mg/kg,50 mg/kg,and 100 mg/kg CKBN.The percentage of mononuclear cells was markedly raised by 1 mg/kg CKBN treatment,and the percentage of neutrophils was significantly increased in the 50 mg/kg CKBN treatment group.IgG2a level in the 100 mg/kg CKBN treatment group was higher than that in the CTX group.There was an induction of phagocytic activity of peritoneal macrophages in the groups with 1 g/kg,5 mg/kg,and 50 mg/kg CKBN treatment in comparison with that in the CTX group.The activity of NK cells was remarkably stimulated in the group treated with 25 mg/kg CKBN.Conclusion CKBN significantly increases the immune function in CTX-induced immunosuppressed mice.


With the daily perfection of the Chinese market economy system,as a universal commercial language,accounting must be in line with international standards in order to adapt itself to and promote the economic development.It is necessary to compare the Chinese and the international accounting standards from the following six aspects: the disclosure of transaction,assets impairment,debt reconstructing,accounting treatment and accounting policy of the government subsides,accounting estimation changes and accounting error correction.We should thoroughly analyze the differences and promote the internationalization of Chinese accounting standards.


The quantitative relation governing the blending time in jet mixing was investigated experimentally by using sodium chloride and sodium hydroxide as tracer. The experiments were carried out in two cylindrical vessels with diameter 0.4 and 1m., respectively. Diameter ratios of tank to nozzle were varied from 36 to 400. Most of liquids used in the tests were tap water and a few were Ucon (Polyalkylene glycol synthetic lubricant) aqueaous solution.It was found that mixing time was independent of the angle of inclination of nozzle. Based on the assumption that mixing time is the function of the mean velocity of liquid across nozzle, the dimensions of nozzle and vessel and the physical properties of liquid, a dimensionless equation has been developed which expresses m ixing time number T as a function of NRen and scale ratios. At NRen ranging from 5×103 to 1×105, T became independent of NRen and the equation was found to be of the same type as that obtained by others for Larger tank blending. It also suggested that the blending of liquid with impeller could be explained with this equation.


Acquired Immune Deficiency Syndrome (AIDS) is rapidly becoming the leading cause of death. AIDS caused by a retrovirus called Human Immune Deficiency Virus results into death of a large proportion of people dies within 5-10 years of infection (WHO 1992). This disease is called Syndrome because it is characterized by a group of signs and symptoms affecting different parts of human body. The virus is known to be transmitted primarily through specific preventable behaviors. HIV infection affects the immune system. HIV destroys bodys immune system by killing the T4 helper cells a subgroups of Lymphocytes and thus impairs the immune system. This causes the individual to become susceptible to various opportunistic infections leading ultimately to death. Deaths in person with HIV infection is caused by weakening and destruction of bodys immune system. (excerpt)


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IJMM 2018; 12(2): 116-124 Background and Aims: Microbial contamination is a great threat to human health. Studies have shown that antimicrobial compounds made from a variety of NPs have high antimicrobial activity. The potential effects of nanostructured metal oxides on the reduction of microbial contaminants are well established. The present study aimed to investigate the antimicrobial activities of magnesium oxide nanoparticles in zeolite matrix on Gram-positive and Gramnegative bacteria.


A 76-year-old man was seen for a neurologic evaluation with concerns of progressive left lower extremity weakness. He had 2 lumbar spinal operations, the most recent being at age 68 years, and had a major motor vehicle accident with a pelvic fracture at age 67 years. He was documented to have new impairment in right ankle and distal lower extremity power after the operations and trauma. He began using a left-sided ankle-foot orthosis but used no other gait aid. Brain magnetic resonance imaging revealed 2 prominent and stable T2-signal hyperintensities in the frontal cerebral white matter, with some periventricular T2 hyperintensity with associated T1 hypointensity, and no gadolinium-enhancing lesions or posterior fossa lesions. Sagittal and axial magnetic resonance imaging of the thoracic spine showed an area of T2-signal abnormality without enhancement in the left hemicord at the T3 to T4 level. Nerve conduction studies and electromyography revealed a chronic right L5 radiculopathy without evidence of active denervation as the cause of the right lower motor neuron lower extremity weakness. He was diagnosed with progressive paucisclerotic multiple sclerosis with a primary progressive disease course. The use of ocrelizumab (anti-CD20) was considered initially. However, the exceedingly slow disease progression over many decades and the lack of new magnetic resonance imaging lesions or gadolinium-enhancing lesions, as well as his age, were taken into consideration, and conservative rehabilitation management was recommended instead. It is being increasingly recognized that the location of demyelinating disease lesions may be of crucial importance in the development of motor progression in multiple sclerosis. These critical demyelinating lesions are observed in patients with progressive unilateral hemiparetic impairment due to multiple sclerosis, in which unlimited lesion burden is allowable.


Objective To investigate the effect of triiodothyronine on the expression of alpha subunit of C protein Co (Coa) gene in cultured rat cerebral cortex neurons. Methods Primary cultured neurons of rat were prepared from the cerebral cortex at embryonic day 19. The neurons were cultured in DMEM supplemented with 15% fetal calf serum. After 7 days, the neurons were cultured in different media; DMEM supplemented with 15% fetal calf serum (group A), DMEM supplemented with 15% fetal calf serum stripped of thyroid hormone (group B), 0.5nmol/L T3-containing DMEM supplemented with 15% fetal calf serum stripped of thyroid hormone (group C) , 5nmol/L T3-containing DMEM supplemented with 15% fetal calf serum stripped of thyroid hormone (group D) and 50nmol/L T3-containing DMEM supplemented with 15% fetal calf serum stripped of thyroid hormone (group E). The neurons were cultured for another 7 days and total RNA was extracted. Goa mRNA leves were measured by competitive RT-PCR. Results As compared with group A, Coa mRNA leves in group B, D and E were low (P0.01). Goa mRNA leves in group C were higher than that in group A, B, D and E (P 0.01). No significant difference in Goa mRNA leves was noticed among group B, D and E (P 0.05). Conclusion T, has dual effects on the expression of Coa gene in cultured rat cerebral cortex neurons. T3 down-regulated Coa mRNA in cultured neuron. However, in the absence of T3, Goa mRNA was also very low. Thyroid hormone may exert their action on brain development by regulating the the expression of Goa gene.


Compares the generalization probability of a perceptron using the Delta -rule with other learning algorithms. The numerical results indicate that the Delta -rule gives results which are superior to Hebb's rule, and comparable with the maximal stability perceptron rule (minover), both for randomly generated linear separable example sets and for optimal queries.


In this paper the superconvergence property of isoparametric bilinear finite elements is considered. A new superconvergence recovery method for isoparametric bilinear finite elements is discovered on the four vertices and the four midpoints of the edges of the elements for piecewise strongly regular quadrilateral subdivisions.


Objective To investigate the attention from Shanghai residents on the medical and health system reform,and put forward suggestions on the medical and health system reform. Methods Multistage random sampling method was employed to investigate 1 600 residents with questionnaire survey. Results The issues most concerned by the investigated residents were rationality of drug use,qualification of training for medical staff,personal payment for medical expense and medical insurance coverage of urban residents. Conclusion The management of drug use should be enhanced,the distribution,composition and qualification of medical staff should be optimized,and the national essential drug system should be carried out to lower the personal payment for medical expense.


An absorption system to purify process air and recover solvents has been developed. The system makes use of a new kind of absorber and evaporator, which are rotary-driven and designed to optimize the contact surface between the gas and the absorbent. A silicone oil was used as the absorbent. A test rig has been evaluated a a pharmaceutical industry in Sweden


The paper analyzes the protection of freedoms and human rights before the Constitutional Court of theRepublic of North Macedonia. The constitutional framework of freedoms and rights whose protection is under thejurisdiction of the Constitutional Court of the Republic is contained in the provision of Article 110, line 3 of theConstitution. It is very narrow and covers the following human freedoms and rights: freedom of belief, conscience,thought and public expression of thought, political association and action and the prohibition of discriminationagainst citizens on the grounds of sex, race, religion, national, social and political affiliation. Such a narrowframework of freedoms and rights whose protection may be subject to proceedings before the Constitutional Court isnot in accordance with the provision of Article 50, paragraph 1 of the Constitution according to which "Everycitizen can invoke the protection of freedoms and rights established by the Constitution before the courts and beforethe Constitutional Court of the Republic of North Macedonia in a procedure based on the principles of priority andurgency." This inconsistency creates confusion in the interpretation and application of the Constitution. Theconfusion has been somewhat removed by Article 51 of the Rules of Procedure of the Constitutional Court, whichaccepts the narrowed constitutional framework. But the Rules of Procedure are bylaws that must be fully based onthe constitutional provisions and derive from them.The second chapter of the paper analyzes the procedure for protection of human rights and freedoms before theConstitutional Court of the Republic. From the analysis of the work of the Constitutional Court in the procedures forprotection of human rights and freedoms, it can be concluded that the citizens do not have much trust in theConstitutional Court. In this regard, there are indications that the Constitutional Court views the work on these casesas a secondary, less important matter. Therefore, he does not pay due attention to them which is opposed to efforts toensure effective protection of human rights in a democratic world.Finally, the third chapter of the paper analyzes the need to introduce a constitutional complaint, ie a lawsuit in thelegal system of the Republic of Northern Macedonia. This chapter points out the division of the expert public in theRepublic regarding the need to introduce this legal remedy in the system of constitutional protection of human rightsand freedoms. A comparative review of this issue is then given by listing the countries in which this remedy hasbeen introduced. After the comparative review, the position of the author regarding the introduction of this legalremedy in the Macedonian legal system is presented. According to the author, the introduction of a constitutionalcomplaint or lawsuit will be a particularly major reform in the protection of human rights in the Republic of NorthMacedonia. Its introduction will significantly contribute to the improvement of the responsibility in the work and thequality of the decisions made by the judges in the regular courts and the officials in the state administration bodies.They, knowing that their decision may finally go to review in the Constitutional Court, will undoubtedly work moreresponsibly and with better quality in conducting proceedings and making decisions.


I n recent years, we have witnessed a rapidly growing research activity that incorporates learning techniques, human preferences, and domain knowledge into evolutionary algorithms for solving complex search and optimization problems. It reflects a basic principle that is theoretically supported by the No Free Lunch Theorem: an efficient and effective algorithm should be able to adapt itself to the problem structure and thus problem-specific. Although numerous research papers on incorporation of knowledge into evolutionary computation can be found in a range of academic journals and conferences, there is a lack of suitable reference books in this area for researchers and practitioners. This edited book aims at addressing this challenge. It carefully classifies the various research topics and presents the state-of-the-art of both techniques and applications in a systematic way. The book is divided into six parts. Part I of the book contains a single chapter written by Xin Yao that provides a concise yet insightful introduction to evolutionary computation. Apart from a generic framework for evolutionary algorithms, theoretical and practical aspects concerning the benefit of using a population, search step-size adaptation, and constraint handling are discussed. Six chapters are collected in Part II describing various approaches to the embedding of a priori knowledge and domain knowledge acquired from the previous search into population initial-ization, recombination, and mutation. Chapter 2 shows how knowledge stored in the form of memory can be helpful in genetic p r o g r a m m i n g-based symbol regression and robotic control. The application of cultural algorithms, a class of evolutionary methods that extract and reuse domain knowledge , to a job shop scheduling problem is presented in Chapter 3. Knowledge extraction and incorporation using case-based reasoning techniques is described in Chapter 4. A chained cultural genetic programming algorithm in which two populations communicate by means of a shared belief space is presented in Chapter 5. The effectiveness of this algorithm is demonstrated in solving nonlinear program problems and simulating consumer markets. The reduction of randomness in mutation and crossover is advocated in Chapter 6, where polyno-mials and neural networks, which are two of the most widely-used surrogate models that are able to exploit domain knowledge hidden in the previous search data and thus speed up evolution, are employed to access the quality of candidate solutions. Consequently, those fitter solutions according to the surrogates are chosen as the final offspring. Part II concludes …


We give a short overview over the challenges and some solutions for using compo-nentware for building critical systems. The high quality development of critical systems (be it dependable, security-critical, real-time, or performance-critical systems) is difficult. Many critical systems are developed, fielded, and used that do not satisfy their criticality requirements, sometimes with spectacular failures. Systems whose correct functioning human life and substantial commercial assets depend on need to be developed very carefully. Systems that have to operate under the possibility of system failure or external attack need to be scrutinized to exclude possible weaknesses. Part of the difficulty of critical systems development is that correctness is often in conflict with cost. Where thorough methods of system design pose high cost through personnel training and use, they are all too often avoided. On the other hand, there is an increasing interest in the use of componentware due to a possibility for savings from potential reuse. This raises the question whether the component-ware approach can be used fruitfully in the critical systems area. Beyond the general arguments about savings by reuse, the componentware approach offers an interesting opportunity for high-quality critical systems development that is feasible in an industrial context. • If reusable critical components can be identified, they can be developed at a high standard of quality, and possibly even certified by official authorities. • If a suitable methodology for component-based construction of critical system exists, these critical components can be employed safely and securely within the system context. Under these two provisos, the componentware approach has the potential not only to reduce costs, but at the same time to increase the quality of critical systems software. This observation prompts some challenges one has to overcome to exploit this opportunity, which include the following:


The invention relates to a method for testing a P-V relation of a brake, which comprises the steps of determining a brake clearance delta and a brake rigid deformation amount delta s of the brake under set brake pressure; determining an original brake required liquid amount Vy under the set pressure; determining a theoretical brake required liquid amount V1 through the original brake required liquid amount Vy; and determining a final brake required liquid amount Vz through the theoretical brake required liquid amount V1. Through the method for testing the P-V relation of the brake, an analysis method capable of effectively predicting the P-V relation of the brake without completion of material object development is effectively solved, and an original method, which must measure the P-V relation through a test after a material object of the brake is developed, is greatly relieved and improved.


The contents of this study is about ideal architecture with the system of the circular plan and studied this symbolic principles of planning or thought in the circular plan architecture It is also proposed that the symbol of the architecture is different from the general symbols in other fields. In the ideal space of the death and resurrection, the axis emphasizes arrangement of the concentric circle, namely the circumferences. It is symbolizes the center as a the being of the eternity arriving through all trials and distresses. In the hierarchy of the space, the center is the most sacred space, but the outer space has popularity. The space of the circular architecture is composed of a closed system. In the inner space the direction of the arrangement of path or walls and visual stream is gathered the center point, and so the outer space is composed of the closed system not easy to approach from the outside and in the inner space is emphasized the divinity certainly. Also this study is suggested that the property of the space in the ideal architecture with circular plan can be offered to adapt in the contemporary architectural space such as monument architecture, religious architecture.


But does it necessarily follow, that his task is to take possession of existing science to bring it to increasing degrees of generality, and to proceed, from condensation to condensation, to what has been called the unification of knowledge? -- Henri Bergson, 1911 -- The main objective of this research is an examination of the funded research database of the Canadian Institutes of Health Research (CIHR) to determine, and graphically illustrate, funding levels of mental health and illness research (MHIR) at CIHR as compared to other health research, and relative funding allocations within the MHIR set of research projects. As our main federally funded health research body, CIHR's funding allocations can be used as an indicator of Canada's health research priorities. This research objective is pursued with a three-part research question: (i) what proportion of health research funded by CIHR from 1999 to 2009 was allocated for MHIR; (ii) how much of this can be considered mental health research versus mental illness research; and (iii) how much of this is neuroscientific research versus non-neuroscientific research? -- This is an in-depth analysis of CIHR's funded research database; in particular, a scrutiny of the abstracts of all projects funded by the Institute of Neurosciences, Mental Health and Addiction at CIHR in its first 10 years, and of all neuroscientific, mental health/illness and addiction related research funded in other virtual institutes and programs of CIHR over the same period. Detailed data sets with information on all relevant research projects are studied; dollar value, program type and research classification of each project are recorded; and each is categorized according to its research objective(s). Pursuit of the present study's research objective demands a methodological design driven primarily by analysis of the data itself. This heuristic process unfolds according to what is found, and produces results on multiple levels with tabular and graphic illustrations when necessary. A clear and practicable distinction between mental health research and mental illness research is employed, and the implications of this distinction for the study's research method are explored. -- The results point to one overriding conclusion: Ostensibly, MHIR as a whole is adequately funded at CIHR, but there is ample evidence that allocations within MHIR may not satisfactorily address all the concerns falling under its extensive mandate. In particular, mental illnesses may well be under-funded and under-researched. Thus closer scrutiny of CIHR's funding allocations within its MHIR, both quantitative and qualitative, is required on a number of levels. Based on the extensive but nevertheless preliminary nature of the present study, further research could ultimately call into question the perceived sufficiency of CIHR's overall funding of MHIR. -- Recommendations for future research are derived from two principal sources: 1) the methodological challenges met in the course of the analysis and its results; and 2) the unexpected limitations discovered in generating the results. The value of the findings for mental health/illness advocacy and for CIHR itself is discussed, as well as the influence of CIHR's funding allocation policies, or lack thereof, on the quality and quantity of the MHIR it conducts. This leads to consideration of Canada's level of commitment to this research area, particularly in light of the burden and prevalence of mental illness in Canada, and the fundamental importance of mental health.


Measurements have been made of the magnetic entropy and magnetization of powdered samples of the compounds Dy2Ti2O7 and Gd3Al5O12 The magnetization has been measured for temperatures at and below 4.2K, in applied magnetic fields ranging to 7 Tesla, Isothermal changes in magnetic entropy have been measured for temperatures from 1.2K to 20K, in applied fields up to 100 kilogauss. The results of the measurements are consistent with a doublet ground state for Dy2Ti2O7, and an eight‐fold degenerate ground state for Gd3Al5O12. Absolute values of magnetic entropy have been obtained at the lower temperatures, permitting the isotherms to be properly located in the S‐H plane with the use of adiabatic magnetization data. The iso‐field lines in the S‐T plane have been determined. The results indicate that Dy2Ti2O7 can absorb a maximum of 71±4 joules/kg of heat at 4.2K, while Gd3Al5O12 can absorb 233±11 joules/kg at the same temperature. The large difference between the two is a result of crystal field interactions in...


Abstract Technological innovations are becoming commonplace in research among persons living with dementia (PLWD) and their caregivers. However, few studies attempt to validate technology's ability to appropriately monitor functional assessment in dementia care research. Bringing together industry, academia, and health care, we demonstrate the feasibility of using a novel in-situ sensor system to continuously and accurately assess daily functions for PWLDs in home or assisted care settings. Phase1 revealed a high accuracy (~85%) of detecting and classifying ADLs between sensors and human loggers across 26 defined activities. Phase 2, which will target 140 PLWDs, has already demonstrated the value of such sensors in detecting safety concerns (e.g., no heat). Technology-driven research for PLWD and their caregivers have practical applications for assessing diverse forms of functional assessment and environmental conditions which can improve measurement precision over time and space and the ability to better tailor care plans for PLWDs and their caregivers.


Studies devoted to the application of numerical solutions of the parabolic equation to the prediction of propagation conditions of radio waves traveling above the ground surface are briefly reviewed. Emphasis is placed on the analysis of the physical irregularities of propagation of radio waves in difficult conditions (above the sea surface, including formation of evaporation ducts and in forests, including the influence of forest and terrain profiles on the radiation field of phased array antennas).


Objective: To investigate the psychological status and its influencing factors in parents lost their only child. Methods: Symptom Check list 90( SCL-90),Simplified Coping Style Questionnaire( SCSQ) and General Self-Efficacy Scale( GSES) were applied to surveying on 186 parents lost their only child( observational group) and another 200 counterparts( control subjects) with general condition inventory. Results: Compared with the controls,the observational group scored totally higher on individual components on SCL-90 and negative coping styles,yet lower on items of positive coping styles,general self-efficacy,and availability of social support and auto-support. The two groups were significantly different( P 0. 05 or P 0. 01). Total scoring on SCL-90 for observational group was positively correlated with negative coping styles,whereas negatively with marriage status and living status,religious belief,willingness to give birth to another child,positive coping styles,availability of auto-support and objective support as well as total scores on social support and self-efficacy( P 0. 05 or P 0. 01). Positive coping styles,marriage and spouse living status,religious belief were positive contribution to mental health,whereas negative coping styles were negatively associated with mental health. Conclusion: The mental health levels are overall lower in parents lost their only child,and associated to a certain extent with their current marital status,religious beliefs,possibility to give birth to another child,coping style to the bereavement,availability of social support and self-efficacy. Coping styles can be predictive role in estimation of the mental health status in this population.


The policy has played an important role from its raising,however,there are some defects all the same.It is significative to build a quality evaluation system for evaluating the total throughput of arable land effectively.The paper took account of operable,scientific and efficiency rules,to calculate throughput indices of kinds of arable lands and different indices of kinds of suitability levels,and then built a matrix of different arable land types in different suitability evaluation levels,finally the model of requisition-compensation balance was built with the help of GIS.


Means (1) for generating a random bit sequence, a digital ring oscillator circuit (2), having at least a first feedback path (R8) and a second feedback path (R14). Here, in the feedback path may advance in a given time (R8 R14,) to switch between, and can be extracted with a random level variation curve (4) at the output node of the ring oscillator circuit (2) is a random signal (OS).


SPARC in Frascati is a high brightness photo-injector used to explore advanced beam manipulation techniques. Sub-picosecond, high brightness electron bunch trains (the so called comb beam) can be generated illuminating the cathode of a RF photoinjector with a laser pulse train and via velocity bunching technique. In this paper different aspects of the physics of this advanced beam manipulation technique are discussed combining simulation and measurements. Beam dynamics numerical macroparticle simulations have been compared with the experimental results for model validation; they allow to gain insights on the beam evolution highlighting several aspects which can not be measured. In particular, we focus on the train evolution in the linac sections and in the dogleg line up to the THz station and on the effective rms length of the single pulses within the train when it becomes shorter than the resolution.


The tunable Q-factor wavelet transform (TQWT) is a fully-discrete wavelet transform for which the Q-factor, Q, of the underlying wavelet and the asymptotic redundancy (over-sampling rate), r, of the transform are easily and independently specified. In particular, the specified parameters Q and r can be real-valued. Therefore, by tuning Q, the oscillatory behavior of the wavelet can be chosen to match the oscillatory behavior of the signal of interest, so as to enhance the sparsity of a sparse signal representation. The TQWT is well suited to fast algorithms for sparsity-based inverse problems because it is a Parseval frame, easily invertible, and can be efficiently implemented using radix-2 FFTs. The TQWT can also be used as an easily-invertible discrete approximation of the continuous wavelet transform.


Application of Municipal Solid Waste Compost (MSWC) to soils could help to solve municipalities' problems. To investigate the effect of MSWC on weed control, yield parameters and some quality indices of green pepper, an experiment was conducted with 0, 100, 150 and 200 t. ha-1 MSWC in 2007 at the research station of the Guilan University, Rasht, Iran. Results showed that with increasing the MSWC to 150 t.ha-1, plant length, branch and flower numbers, plant total fresh and dry weight, vitamin C content, chlorophyll a, b and total leaf chlorophyll of green pepper can increase significantly. Higher levels of MSWC (150 and 200 t. ha-1) didn't showed any significant differences on the above mentioned characteristics. However, high an increasing of 150 up to 200 t. ha-1 MSWC could affect the yield, fruit and leaf numbers, fruits chlorophyll a, b and total chlorophyll content. Application of MSWC higher than 150 t. ha-1 could decrease significantly the numbers of several weeds such as Amaranthus spp., Convulvulus spp., Bromus spp., Cinidon spp. Plantago spp., and Digitaria spp. Further increasing of MSWC up to 200 t. ha-1 could not affect the number of Bromus spp., Cinidon spp., Plantago spp., and Digitaria spp. Our results showed also that fresh and dry weight, Zn and Cu content of pepper could increase with increasing of MSWC without any significantly differences.


The gas-solid two phases flow characters in an electret filter was simulated by computational fluid dynamics(CFD) method,and the internal electric field distribution,pressure drop and the permeability of the electric particles which pass through the electret filter were calculated.The results indicate that the electrostatic force is dominant when the particle size is smaller than 0.1μm;the effect of the electrostatic force on the permeability of the electret filter wear off with the increasing particle size;the permeability of the electret filter is increased with the face velocity when the particle size range is 0.05-0.5μm.In addition,it can be seen from the movement of particle trajectory in the electret filter,some particles are deposited on the back of the electret fiber,which may be one of the main reasons of low permeability and low pressure drop in the electret filter.


Preliminary study of a transoceanic surface effect ship (SES) (GEM) is made to evaluate its commercial feasibility. Ship specifications of operating height and speed are determined for the ocean environment, and a range of sizes is considered to define the power requirements. Powerplant weight is a critical factor and state-of-the-art research is performed for suitable nuclear powerplants, and different cycles are analyzed. Optimum ship size is determined through parametric studies, for a range of powerplant specific weights. Vehicle characteristics are then determined and general arrangements are made for optimum sizes considering payload and operating cost factors, identifying a 6000-ton ship as a practical size. Structural design criteria are developed for the 6000-ton ship. Truss-type structure is found most suitable for minimum weight. Machinery weight estimates are made for the complete installation and development needs are identified. Commercial feasibility is evaluated over North Atlantic routes. The study concludes that construction of a nuclear-powered SES is feasible using present technology, but its cost characteristics would be commercially marginal. Further development of the nuclear powerplant is practical and would result in a competitive ship.


Introduction Spinal deformity is one of major orthopaedic manifestations of cerebral palsy (CP). Despite the prevalence of the nosologic condition there is a deficiency in the availability of criteria for screening and management of the spinal pathology in CP patients, difficulties in interdisciplinary logistics, lack of registry and restraints in the continuity of the rehabilitation system. The purpose of the work was to focus the attention of mainstream audience of dedicated experts on the aspects of the course and correction techniques of spinal deformities in CP patients. Evidence level 5 (UK Oxford, version 2011). Results The type of spinal deformity depends on the functional level classified with the GMFCS. Vertebral evaluation included identification of the leading component of the deformity, apex location, mobility, trunk balance, chest deformity, type of pelvic obliquity, the way contractures and dislocation of the femoral heads affected the lumbar spine mobility. The goal of spinal deformity correction in CP patients is to maintain or improve the functionality of the patients, improve the quality of life for the patient and the family. The use of transpedicular multi-support fixation systems and bone allografts can be recommended for bone fusion in the patients. Spinal fixation can be extended from the upper thoracic vertebrae down to the pelvis. Dynamic fixation systems, multilevel or multi-rod fixation can be an option depending on the age, extent of the maturity of the axial skeleton and size of the curve. Conclusion The severity of manifestations of spinal deformity increases in CP patients with greater level of global motor functions and does not depend on the skeletal maturity. Conservative treatment is ineffective at a long term. Correction and instrumentation transpedicular fixation allows for threedimensional correction without the need for anterior fusion. Surgical treatment significantly improves body balance, functional level and quality of life.