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Today, I tour other Greek sites in Ancient Ionia. The coin of the Day is an Ionian coin.
Coin of the Day: Drachm of Teos, 500-460 BCE
Teos is one of the cities that was in the Ionian League. This is the only coin I have from any of those cities, and shows a griffin on one side, and an incused quadrangle of four squares on the reverse. (I suspect that pattern actually helped keep the planchet on the anvil during striking and has no real significance.)
Drachm, by the way, really ought to be pronounced with the ch, as a guttural sound like Scottish Loch or German Ach, but most American collectors just say "dram," even getting the vowel sound wrong (it should be somewhat like the A in "father" and not at all like the A in "hand"). If you don't want to take the chance of spraying that ch on the person you're talking to, then "drock-um" is still a huge improvement over "dram."
The modern Greek nation, harking back to antiquity, used the ΔΡΑΧΜΑ–drachma of 100 leptons as their monetary unit before they adopted the Euro (and maybe they got the last laugh–I'll explain that in a future post).
Priene, Miletus, and Didyma
So now on to today's tourism, the Ionian cities of Priene and Miletus, and the Sanctuary of Apollo at Didyma.
Here's the modern map of this part of Turkey. Kuşadesı (where I spent the night) was at the south end of the day's travels yesterday; it's now at the north end of today's map. This means, as a practical matter, that we are no longer in the Little Meander valley, but rather in the Meander valley, which means the silting up I mentioned is an even bigger issue here. I pulled the following straight out of Wikipedia:
You can see various cities of the Ionian league (including some on the island of Samos, which is still Greek territory) and can note just how far inland some have gotten.
After waking up in Kuşadesı, I was picked up by one van, which took me to another van, where I joined my tour group for the day, a couple from Oz. From there we went to Priene, which is, frankly, not all that well preserved. Its biggest landmarks are a Sanctuary of Asclepios and a temple to Athena, but there is also an early Christian church and a few other odds and ends.
You will see a man in a white T-shirt in quite a few of the pictures. This was our guide (and I've long since forgotten his name, unfortunately). He didn't speak a whole lot, and was oftentimes content to let us wander and make our own discoveries. When he did talk, as a consequence, his words carried a lot of gravitas. He described the sorts of awful things that happened to unwanted Roman babies one time, and had our full attention. A very different style from yesterday, and just as good in its own way.
This is the city hall. One wonders how much time here was spent listening to someone complain about his neighbor's plans to open a business, and all the other issues that seem to occupy city governments these days.
Here's a shot down the road towards what used to be the ocean, and is now the flat-as-a-plate silted-up Meander river valley.
One thing about ancient ruins is you can often get insight into ancient building techniques. You can see here the iron bar used to tie two stone blocks together, as well as (upside down) a carved letter "rho" used to label the blocks. I'm not sure what the other holes are but they may have been used to lift the block.
Sanctuary of Asklepios. One of the other people in my tour group actually found a (recent!) ten kopek piece here; evidently some people still leave offerings.
So walk up this staircase to get to the Temple of Athena.
These columns were re-erected recently, but apparently the scholarly consensus is that they are about ten feet too short. I have no idea where they think the mistake might have been.
Here's the early Christian church.
No Greek ruin is complete without a theater, and Priene had a small one. Note the larger chairs on the bottom rows, for the most important personages of the city. I called them "muckey mucks" and the Oz couple had never heard that term before but swore they'd start using it.
None of us could resist playing muckeymuck.
This is enough to make one wonder why they bothered photographing the Priene theater!
Note the arched entryways to the higher levels, a Roman retrofit. The Romans increased the capacity from about 5300 to 15,000.
Remember earlier I highlighted the iron bars used to tie blocks of stone together? Look closely here and you will see holes dug into the rock at the joints. This was due to people in the middle ages (or perhaps later) deciding they wanted the iron in those joints, and treating this theater as an iron mine.
The corridors bringing people to the upper levels are gigantic, and as you can see, pretty well preserved.
On the other hand the corridor behind the very top row of seats hasn't held up so well. (And it looks like more iron mining took place here, to boot.)
Two views of the theater from up high.
And don't forget this is Turkey!
On to the Faustina Baths, established by Faustina, the wife of Marcus Aurelius.
Marcus Aurelius was the kindly Emperor of Rome portrayed at the beginning of the movie Gladiator, killed by Commodus. There's no reason to believe Commodus actually offed his father in real life, but it is true that his rule marks the beginning of the decline of the empire; after a century of stability under the Five Good Emperors (Nerva, Trajan, Hadrian, Antoninus Pius, and Marcus Aurelius) the empire wouldn't see any sort of stability for over a hundred years. Commodus, you might say, flushed the Roman Empire down the commode.
There is a lot of these baths left, but it's difficult to convey the size and complexity of the facility with pictures. This is a shot I took of a map; I'll try to figure out what the pictures are of.
I'm pretty sure this is the Apodyterium.
And the Frigidarium (cold water baths).
You get the impression this was a really impressive structure in its heyday.
Didyma, the Sanctuary of Apollo
This was a surprise. This place was freaking HUGE, and fairly well preserved, all things considered. Again, camera can't give an impression of the sheer size.
This is similar in concept to the Oracle at Delphi. There was even an oracle here. But this is not very famous, whereas Delphi is famous. But (spoiler alert), this one is a far more impressive sight (and site) than Delphi is.
You get a sense for the sheer size of this thing by seeing the people in this picture. Then note the height of the two pillars that somehow managed never to get knocked over during the intervening millenia. (Unlike many places we've seen, those were not restacked during recent times.)
This aerial photograph shows the general layout. The previous picture was taken looking from the upper right on this photo. The courtyard of the sanctuary (right side of picture) has a lot of partial pillars in it, all much taller than we are. There's a fenced off area just to the left of this. Hidden from view are ramps at top and bottom, leading into the large open area on the left, which is a recessed area that the Oracle used. We circumnavigated the outside of the temple, counterclockwise, bottom edge, left edge, then top edge. Then we went through the courtyard and took the ramp inside the bottom wall on the picture (to the left, facing the structure). We then came out the ramp near the top.
Before even starting this, however, we looked at some of the fallen down pieces (you can see hundreds of pieces laid out around the footprint of the actual sanctuary in the photograph). Here are three examples of artwork that survived.
A look at the fancy artwork around the base of a column.
Now beginning to walk along the bottom edge (in the photo) or left side of the temple. Note most ofthe columns are completely gone, all you can see is a raised spot in the gigantic pedestal the whole thing rested on.
Shot of the standing columns, which are on the other (upper in the photograph, right side as you face the front) side of the sanctuary. It was impossible to get a good photograph of them while standing right under them. It turns out though that the bottom ten feet or so have been reinforced with concrete, so that hopefully they will stay standing.
Upper, right side, returning to the front of the temple. You can see how many layers of stone blocks had to be stacked, just to create the platform for the temple to sit on. In the distance you can see the bottom part of one of the two standing columns.
Now standing in the courtyard, looking at one of the entrance ramps into the lower area.
Looking down the ramp
Then back up it. Thankfully the marble on the floor of the ramp is grooved. (It's amazing how slippery marble is, particularly after thousands (or even millions) of people have walked over it.)
One of those rare places where an unarched roof survives in part, and it's decorated.
At the far edge of the recessed area, looking back towards the broad staircase, with the two ramps on either side of it.
Not zoomed in so much, so you can see how big this place is–and the retaining walls are intact. The area immediately in front of me here is probably where the oracle sat.
Now standing on the steps, for a reverse angle.
Having exited, here's another column we noticed.
Closeups of some of the motifs.
After this, we had lunch at a nearby restaurant (fish), then I got taken back to the Izmir airport, arriving back in Istanbul airport after dark.
The hotel staff tells me it's 45 minutes by public transit to the Sultanahmet area, where my tour of Istanbul jumps off at 8:30 tomorrow.


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Extraordinary talent needs extraordinary inspiration
Stet, a troubled and angry 11-year-old orphan from a small Texas town, ends up at a Boy Choir school back East after the death of his single mom. Completely out of his element, he finds himself in a battle of wills with a demanding Choir Master who recognizes a unique talent in this young boy as he pushes him to discover his creative heart and soul in music.
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eBook Title for Download :Hyperbolic Problems and Regularity Questions (Format : pdf , Language : English)
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This book discusses new challenges in the quickly developing field of hyperbolic problems. Particular emphasis lies on the interaction between nonlinear partial differential equations, functional analysis and applied analysis as well as mechanics.
The book originates from a recent conference focusing on hyperbolic problems and regularity questions. It is intended for researchers in functional analysis, PDE, fluid dynamics and differential geometry.
Author(s) Book :Luisa Zanghirati, Mariarosaria Padula
Publish Year :2007 Publisher :
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Pages :228
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Good Morning!
The next day, I woke up early for an early morning stroll in the park. I had wanted to watch the sun rise. At the jetty were boats ferrying people to and fro the islands. An old grandma had just parked her old bicycle laden with the day's newspaper.
I began to take photo. Then I realized, I had made the greatest mistake in digital photography - not having enough power supply!
I had to rush back to the hotel. Get a fresh set of battery. Unfortunately, like this old man (photo will be added later), the magic hour had passed. The jetty and the park was empty. Those people were commuters communiting to work. Nevertheless I continued walking, enjoying the soft morning breeze.
Before long a man stopped me for a chat. He wore a simple clothes. He had a little bag under his right arm. He had noticed me taking photos earlier. The park was a little deserted. I was a little alarmed. As I told him that I used to live here (trying to give the impression that I'm not exactly a tourist), I moved slowly so that I had my back to the more 'populated' part of the park. I was ready to flight should it was needed!
But nothing untoward happen. I told him that I need to get to work. The guy continued his journey. I made my way to the hotel. I really did need to get ready to go to work.
(p.s. I'm updating this post while on the bus to work. Pardon me for any grammar / spelling mistakes.The traffic is amazingly smooth! I guess it is because everyone else is already in the office.)
Monday, September 22, 2008
Posted by Me mobile at 9:34 am
Labels: 2008, going places, Malaysia
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2015 Audi A3 to Make LA Auto Show Debut
The 2015 Audi A3 will finally make its North American debut at the 2013 Los Angeles Auto Show this week.
The compact sedan is aimed to compete against the new Mercedes-Benz CLA. Starting from $30,885 the 2015 Audi A3 sedan will come with a panoramic glass sunroof, leather seating surfaces and bi-xenon headlights.
SEE ALSO: 2013 LA Auto Show Coverage
The standard engine on the Audi A3 sedan will be a 1.8-liter turbocharged four-cylinder with 170 hp, while a trio of 2.0-liter four-cylinder engines will be available as an option: a pair of gasoline engines and a sole diesel option. The diesel will output 150 hp while the S3 is expected to have around 300 hp. The German automaker is expected to share more details on the available powerplants when the vehicle makes its debut at the 2013 LA Auto Show.
Joining the sedan model at the show will be the Audi A3 e-tron, a plug-in hybrid that appeals to the hatchback fans.
GALLERY: 2015 Audi A3 Sedan
Discuss this story at our Audi forum.


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Why Do My Teeth Hurt When I Eat or Drink Something Cold? Cold Sensitive Teeth
Have you ever taken a sip of cold water or took a bite of ice cream only to have a sharp, stinging pain develop around your teeth? If you have, you could be suffering from what dentists call cold sensitive teeth.
Read ahead to learn more about cold sensitive teeth and discover some ways you can prevent your teeth from being in pain after eating or drinking something cold.
Why Do My Teeth Hurt When Exposed to Cold Food or Drink?
Your teeth hurt when you drink or eat something that is cold because the nerves are exposed. The nerves on your teeth are exposed when the gums, which are supposed to protect your teeth, start to recede, when tooth decay has worn away at the enamel of your teeth, or other problems occur to your teeth such as cracks. These problems cause the nerves on your teeth to be exposed and come into direct contact with the cold food or drink which causes the pain you experience.
How to Avoid Experiencing Pain If You Have Cold Sensitive Teeth
If your teeth are sensitive to the cold, there are a few things you can do to help avoid experiencing that sharp, stinging pain every time you eat or drink something cold. Some of the things you can do include:
- Use a soft bristled toothbrush as this helps to protect your teeth and won't cause damage to the enamel around your teeth
- Use a toothpaste that is specifically designed for sensitive teeth
- Avoid any foods or drinks that are too cold. If you can't avoid it, try to eat it in such a way that the cold food or drink won't come into direct contact with your teeth.
If you have cold sensitive teeth, you may want to schedule an appointment with your dentist to make sure you aren't suffering from a severe dental problem such as an abscess or cavity. Sometimes abscesses and cavities can cause sensitivity to cold. It is best to have a dentist check to make sure your teeth are just sensitive and not suffering from any of these problems.
Contact Tumwater Family Dentistry to schedule an appointment for a routine dental exam. Our dentist can help determine if there is a problem causing your cold sensitive teeth.


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Wednesday, June 22, 2011
Surviving My First Year as a Published Author, by guest blogger Karen Witemeyer
27 comments:
Great advice--thanks!ReplyDelete
Really enjoyed this, Karen! Thank you for taking the time to offer insight into "the next step" of an unpublished writer's journey.ReplyDelete
Mitzi and Kathy - Thanks for stopping by today. There is always more to learn, isnt' there? I'm still feeling my way along the path.ReplyDelete
Have a blessed week!
Karen, I'm a reader not a writer but I still enjoyed all the tips that you wrote about. I even loved the scripture you quoted from Proverbs 11:2. Also, you said not everyone would love their book so gird your loins in advance. As a reader I will admit I haven't read too many books I didn't like. Shouldn't this be encouraging to a writer? :) I would love to win a copy of your newest release, To Win Her Heart. This book sounds really good. Reading is my passion!ReplyDelete
I absolutely love your books. You're one of my all time favorites. I can't wait to read the newest one. I loved this article. Very interesting.ReplyDelete
Is this book a sequel to Tailor-made bride? I enjoyed this book so much. It was so good I couldn't put it down. After I finished it, I wanted more. Your a very good author and have a lovely ablitity for challenge one spiritually. Thank you.ReplyDelete
Regardless if this is a sequel or not I would like to be entered in the drawing.
Loved your first two books. Can't wait to read this one! I'm not a writer either but enjoyed the info!ReplyDelete
I loved your first two books and cannot wait to read this one. The information on how to become a successful author was great, too! You are truly a talented gal, Karen!ReplyDelete
Thanks for the great advice! I wish you much success on all of the books you write!ReplyDelete
Hi, Judy. You are EXACTLY the kind of reader we authors adore! Easy to please, enthusiastic. Nothing could be better. With all the critics in this world, it is such a blessing to have readers like you out there. Keep reading!ReplyDelete
Katey, Candice, and Mobile Beauty - Thank you so much for your kinds comments. I'm so glad you've enjoyed my books. You are certainly entered in the drawing!ReplyDelete
Anita - To Win Her Heart is not a sequel to Tailor-Made Bride. It stands alone, but you will find a similar time period and setting. I hope you enjoy it!
Leeswa - Thanks for the encouragement! I hope you found something to bless you along your own journey.ReplyDelete
I will be so excited to read your newest. I have read your other two so far and LOVED them. Enter me, please.ReplyDelete
Wow, Karen, it is hard to believe it was just a year ago that you asked me to be an influencer for your first book that came out. Of course I loved it and posted my review and was also recently able to get your second book's review up on my blog and now the third is out. Whew! Thanks so much for sharing your journey. I do have a freelance editor who works with me so my "hope" is that when an editor from a publishing house gets ahold of me that it may not be tremendously painful thanks to Susan's help! Blessings to you, Karen, and congrats!ReplyDelete
Hi Karen,ReplyDelete
I can't believe you've had all 3 books out within your first year! Wow - lucky us!!
Thanks for these great tips. I will keep them to ponder for the time when I have my first contract.
No need to enter me in the draw. I have your book in my TBR pile!
Maudie-Mae, Your enthusiasm makes me smile. Thanks so much for your kind words. You are definitely in the drawing!ReplyDelete
Carrie - It's hard to believe a full year has gone by. How time does fly. Thanks for all the support you've given during this journey. Travelling together makes the road so much more fun. I can't wait to see a books of yours in the mix!
Hey Sue - Thanks for the encouraging words. You always make me smile. I hope you enjoy Levi and Eden's story when you whittle down your TBR pile enough to meet them. so many great books, so little time. Oh, how I can sympathize!
As someone in your position, every word you say is true. I write like you do and also can't resist reading my reviews. I have your debut on my Kindle and can't wait until I have the time to read it. I hear good things. So happy for your successes!ReplyDelete
Thanks, Gina. That means a lot. I'm wishing you the best at the Christy's next month!ReplyDelete
Thank you so much for sharing this post. I am new to all of this so it really helps to get other people's insights.ReplyDelete
I'm so glad that you started writing! I've read both A Tailor Made Bride and Head in the Clouds and I loved them both! Head in the Clouds is definitely one of my favorite books of all times :) I could not put it down and was sad when it ended. Keep writing! Thanks so much.ReplyDelete
Hi, Deborah. I'm glad you found my post helpful. I hope that you get to experience this part of the journey yourself soon.ReplyDelete
Casey - You've made my day! I'm so glad you enjoyed my first two books. I had so much fun writing Head in the Clouds. I lke to think of it as my Texas fairy tale. I hope you enjoy To Win Her Heart equally well.
Great advice, Karen! I am a few months behind you so enjoy knowing what to expect when my first book comes out in Sept. Your first two books were great, so put me down for a chance to win this one!ReplyDelete
I so appreciate your honest advice. My biggest fear about becoming a published author is that it will never come! However, if it does, I will remember the tips you've shared from your journey!ReplyDelete
Even though I don't write books I do write reviews and post them on various sites. Thank you for the advice on good and bad reviews. I will never forget the bad review I received of my review. I had neglected to say that the dog in the book was not the same breed as the book lets you think in the beginning. Bad reviews teach me to be more careful. I look forward to reading 'To Win Her Heart".ReplyDelete
Honestly? The thing about getting published that unnerves me the most is the follow up novel.ReplyDelete
I've been marketing and dealing with rejections in the art world for over 30 years, so that's not a problem.
But if I sell one novel and can't come up with a second one? That's the monster under my writing bed!
Karen, this is excellent advice. I just received my first edits from my publishing house, so timely advice for me as well! I just love all your books and am so excited that you had such a remarkable year!ReplyDelete
Please don't enter me in the drawing as I have a review copy.ReplyDelete


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|Assorted dumplings
I am such a sucker for yum cha. I love it. The Eight is my favourite yum cha restaurant at the moment. It's closely followed by the fish markets and then probably Sky Phoenix.
Thanks to Mel for taking me here and putting up with my hung over antics over several occassions


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Dor Guez: The Sick Man of Europe
15 Sep 2017 – 29 Oct 2017
Event times
Tuesday-Sunday 11am-7pm
Cost of entry
With this exhibition Guez examines the cultural history of several states in the Middle East through the stories of artists who were recruited to the army and took part in various 20th century wars.
Dor Guez's solo exhibition at DEPO Istanbul, comprises the second of the five-part project, "The Sick Man of Europe." The project includes works in various media such as video, installation, photography, scanogram, and sound.
"The Sick Man of Europe" is a term taken from the end of the 19th century to describe the collapse of the Ottoman Empire and "The Sick Man of Europe: The Architect" focuses on the story of Kemal P., an architecture student who was recruited to the Turkish army just after he graduated in the late 1930s. A two-channel video installation focuses on thirteen of Kemal's photographs from 1938 that document the Turkish Republic's Victory Day Parade in Ankara in August of the same year, and the funeral of the republic's leader, Kemal Ataturk, that took place a few months later. On one channel we hear the story of Kemal P., the architecture student, while he narrates the photographs, commenting on the documented sites and events. The second channel shows sketches of the architectural setting that surrounded those events. By focusing on the buildings, monuments, and squares such as Atatürk Forest Farm, Zafer Square, Güven Park, and Ulus Square, one can track the architectural changes that took place in Turkey during its transformation from Ottoman Empire to the Turkish Republic. Parallel to documenting the historic evolution of Turkey, a story of friendship unfolds in the photographs shown in the video between Kemal P. and his friend Ahmad.
The video begins with an historical story about the Turkish Republic's "architect" Kemal Atatürk. In 1929, Atatürk traveled by boat from Istanbul to Bursa. Along the journey down the coastline of the sea of Marmara a plane tree captured his attention. He was so enamored by the tree that not only did he build his private residence adjacent to it, but when the tree's branches grew too close to the building, threatening to damage its windows, Atatürk chose to move the mansion rather than alter the tree.
The exhibition also includes hundreds of photographs of uniformed men (i.e. soldiers, policemen, scouts) in military parades, army camps, field training, studio poses, and group, couple, and individual portraits, which were collected through the years by Kemal P.


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I had the privilege during my travels in the States last month to visit a democratic free school (based on the Sudbury model) and a homeschool resource centre. I graduate from a different democratic free school seven years ago (🙀), and I found myself drawing a lot of parallels but noting a few key distinctions.
In both communities, the spaces are clearly student-centred, with couches and large community tables in place of rows of desks. Students have access to shelves and shelves of all different genres of books, musical instruments, computers, art supplies, and other resources. There is a School Meeting once per week in which the community votes on key issues of importance to the community. There is a small Judicial Committee composed of youth and staff that handles small issues that concern just one or a few members of the community.
At this particular democratic free school, to graduate, students must write a thesis demonstrating their readiness to leave the support of the free school community and enter the adult world. One of the staff members pointed out that he would never have been able to do that when he was a senior graduating from high school. It does seem to be a more authentic way of demonstrating one's readiness to move on to the next stage of life than a bunch of letter or number grades given to you by an authority figure that are supposed to tell you about what facts you have memorised.
Some key differences between these models of education and compulsory schooling: facts (which can be and often are easily forgotten) vs. skills (which will serve us for life), and what to think vs. how to think.
Since August, I have been teaching New Entrants (five-year-olds) in a wonderful, student-centred, progressive school. I adore my colleagues and administration and am fortunate to have a lot of liberty in how my classroom runs. Our syndicate is embracing play-based learning, and there has been a marked shift to supporting skill-building and tamariki (children)'s own inquiry process. I have been trying to work out how much of my unschooling and free school background I can bring into my classroom while still working within a conventional school environment. So that brought me to re-examining what my role is. What is my responsibility as an adult in the classroom?
There is clearly:
Do no harm.
Nurture my children's natural curiosity.
Facilitate opportunities for deeper inquiry.
Facilitate development of strong social-emotional skills so that tamariki grow up able to articulate their own emotions and successfully navigate conflict with others.
Nurture an environment in which each child feels welcome and supported and sees their culture and identities represented.
What more would you add to this list? What are the concrete actions we are/should be taking to fulfill these responsibilities every day?


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Leidner gains confidence at passing camp
It took Mitch Leidner just three seasons to go from a quarterback with two college offers to one working with Peyton and Eli Manning.
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It took Mitch Leidner just three seasons to go from a quarterback with two college offers to one working with Peyton and Eli Manning.
This season, Minnesota head coach Jerry Kill is looking for offensive lineman with "some lead in their tail end."
Target will begin using chip readers for credit cards in 1300 of its location by this week, the Minneapolis/St. Paul Business Journal reported.
A Zimbabwean diplomat said his government is working to quickly extradite Eden Prairie hunter Walter Palmer, who allegedly shot and killed Cecil the Lion, a well-known research lion, the Star Tribune reports.
For two years, I swore off McDonalds. The golden arches made me think of nothing but toxic artificiality and cheapness. They made me feel like I was among the living dead. While I used to gobble down McChickens en masse on road trips, certain lifestyle changes made me kick that habit and not look back. Heck, the only time I tasted anything from McDonalds during the time frame was for an article I wrote about Shamrock Shakes. After tasting the saccharine elixir for journalism's sake (ice cream is an inappropriate word to describe the pathetic concoction I tried), I threw it away after three sips.
A new law will take effect Saturday to increase fines for drivers who are caught texting two or more times, WCCO reported.
A 43-year-old doctor from Pelican Rapids pleaded guilty on Wednesday morning for stealing prescription drugs.
Minnesota's minimum wage will see a hike up to $9 per hour starting this Saturday, the Minneapolis/St. Paul Business Journal reports.
Two plane crashes occurring within a few hours of each other in and near Minnesota have left seven people dead, the Star Tribune reports.
Shae Kelley returns to Lynx
Some state Republican lawmakers say that Minnesota National Guard and U.S. Armed Forces members shouldn't be required to secure a permit to carry a firearm in the state, the Star Tribune reported.
The University of Minnesota Accessibility Observatory announced Monday that they will be partnering with TomTom, a navigation device company, to create a dataset to document transportation accessibility to jobs across the U.S., according to a University press release.
The historic Fort Snelling military buildings in disrepair will soon be transformed into affordable housing, reports Minnesota Public Radio News. The project will cost $100 million dollars and will bring new life into the deteriorating buildings that were once a military hub, reports the Star Tribune. According to the Star Tribune, the housing will be available for tenants who make under $60,000 dollars a year and rent is estimated at about $900 for a one-bedroom apartment.
Emergency contraception use in teen girls is on the rise, according to a Centers for Disease Control report released Wednesday, with one in five having used the morning after pill. The use of the morning after pill by teenage females has increased by 14 percent since 2002, according to the report that analyzed sexual activity, contraceptive use and childbearing for teenagers ages 15 to 19. The report interviewed about 2,000 males and females.
Minnesota is the best state for childhood well-being according to a report released today. The annual report released by the Annie E. Casey Foundation, called Kids Count, ranked Minnesota near the top for education, the economic stability of families, child death rate and teen drug and alcohol abuse compared to other states.
On Tuesday, MillerCoors announced sponsorship of the Minnesota Vikings to become a Founding partner of the new U.S Bank Stadium, the official Vikings website reported. The partnership will include a MillerCoors branded party deck in the southwest corner of the stadium and a branded space within Club Purple, a Vikings-themed social club, according to the website. The partnership will last at least 10 years and marks the first founding partnership the Vikings have announced for the new stadium, the Minneapolis/St. Paul Business Journal reported.
The Minnesota women's hockey program won the NCAA championship in 2015, despite former Olympian Amanda Kessel sitting out the season due to lingering concussion symptoms. The program will continue to move forward in Kessel's absence, as Minnesota head coach Brad Frost confirmed to the Minnesota Daily on Tuesday the forward will not return for the 2015-16 season due to continuing injury concerns. "Her health takes number one priority, so we determined together that it would not make sense for her to play for us next year," Frost said.
The final day of the festival left everything that came before it behind. Audiences enjoyed beautiful weather, higher attendance and acts that held nothing back. The energy of the night felt chaotic at times due to the packed Union Park -- an increased police presence suggested that the city prepped for a volatile situation. It proved to be unnecessary as the sun came down on a joyful crowd of thousands singing along with Chance the Rapper and feeling the love.
Janzen helps lead Team USA to victory Former Gophers swimmer Kiera Janzen participated in the Pan American Games in Toronto July 14-18. The six-time All-American swam in three events at the games: the 200m Freestyle, the 400m Freestyle and the 4x200m relay. Janzen took 6th and 5th in the Freestyle meets, the 200m and 400m, respectively, but had an exciting run in the relay. The relay team including Janzen won the race and a gold medal. In addition to winning gold, the team beat the previous Pan Am relay record by seven seconds with a time of 7:54.32.
The first day of Pitchfork's 10th annual music festival started with brutal weather. Concertgoers at Union Park experienced temperatures above 90 degrees with a healthy haze of humidity. Though the extreme conditions persisted through the day, Friday's lineup was full of impressive acts. From spaced-out punk to glitched, blippy electronic music, artists ran the gamut and beat the heat — for the most part.


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On the web
Triple R Construction and KLR Construction Ltd in Manukau Franklin is an independent Franchisee of Refresh Renovations
On the web
Triple R Construction and KLR Construction Ltd in Manukau Franklin is an independent Franchisee of Refresh Renovations
That good old Kiwi quality – experience - is at the heart of what Steve brings to our business.
Having started out in the building trade at the tender age of 18, Steve gained his building skills from working with his dear old Dad for 18 years, and he hasn't looked back. He's gone on to manage renovation projects with budgets as tiny as $350, to sizeable budgets of $9 million plus. Along the way, he's collected all of the skills required to be a successful project manager, including an understanding of the entire build, cost allocations and that critical skill – time management.
Steve is a champion multi-tasker, which is one of the most recognised skills successful project managers hold. Being able to juggle multiple projects at one time, whilst not dropping the ball on any, is Steve's forte. Using systems to support the delivery of tasks on time and on budget, is one of the keys to his success.
Satisfaction for Steve comes from delivering to his clients what has been promised, and he achieves this by taking time to fully understand client needs and wants. If that picture looks flawed to Steve's professional eye, he will be sure to provide his clients with alternative options that will deliver the successful outcome they are seeking.
Born and bred in Auckland south, Steve is a dedicated family man, and has been married to his lovely wife Karen for over 20 years. He and Karen have survived the teenage years, and their two boys Jake and Dylan are doing them proud as they head towards adulthood.
During the summer months, you'll find Steve trying his luck in local waters as he attempts to catch "the big one" on yet another fishing escapade. And if that doesn't work, he'll throw on the scuba gear and hit the sea for a dive! If the fishing's no good, he'll pop on some skis, soak up the sun and try his luck out the back of the boat, water skiing with friends and family.
Having spent 15 years playing rugby for Pakuranga United, and then a further 15 years coaching rugby teams, come winter time you'll find Steve watching his favourite game. As per Kiwi tradition, he'll, of course, be offering up suggestions from the couch. Go the AB's!
We're ready to help you with your home renovation project.
If you would like to find out how Refresh Renovations can provide you with a high quality, efficient home renovation, get in touch today. One of our friendly renovation specialists will be happy to meet with you for a free, no obligations consultation.Get in touch
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Every good product you see around you was meticulously designed and was designed to solve to an existing problem. These products have led us to advancement, making our life faster and more efficient.
To sustain/grow in today's competitive market, every company needs to focus on improving their product quality or developing new products. While setting a high quality standard, company also has to look at improving system design, performance of manufacturing processes and selection of elements in automated system. Furthermore, this will result in to reduction of cost and time-to-market. We assure you the best solutions to your system problem when in nee
The entire process in developing a product consists of four basic steps.


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Promote & Develop
The aim of our organization is to promote and develop intellectual property in the state of Iowa
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We help professionals grow by providing continuing legal education (CLE) for members.
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We have a strong focus on the next generation of STEM students, as well as current law students.
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2019 IIPLA Conference
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Pregnant by the Billionaire by Karen Booth: When you look across the room and you just know that the person you are looking at is the one you are going to be spending the night with you don't ask a lot of questions. When they don't call you, then you start wonder…until you can't.
Kendall Ross knew who she was with that night at her friends wedding, but she also thought she deserved a call and when she didn't get one, she built her walls. Every day her walls got higher until she walked into her conference room at work and realized that her walls might not be high enough.
Sawyer Locke was used to getting what he wanted. He worked hard for it, but he got it. He didn't let things get in his way nor did he let people get in his craw. One-night stands were his standard. He didn't realize that one night in Maine at a wedding would stick with him for so long. So when he saw Kendall again he started to wonder if more than one night was going to be possible.
Working together, fighting perceptions and throw in some unsuspecting drama; these two have their work cut out for them. Their future is anything but clear.
Ms. Booth has begun an interesting series on the Locke family with this novel. While the love story of Kendall and Sawyer does wrap up fairly nicely the story of the Locke's leaves the reader needing more. Ms. Booth does a wonderful job of helping the reader get invested in the family and wanting to know more and more about what is going to happen, at times more so than the romance. This is definitely an intriguing book and one that will have you desiring more knowledge of this "prohibited" family.
Book Info:
Publication: Published July 4th 2017 | Harlequin Desire |
Kendall Ross's latest PR assignment is the perfect jump start for her career. But her client is hotel magnate Sawyer Locke–the no-holds-barred one-night stand she had six weeks ago. Sawyer knows the feisty redhead is the key to successfully launching his new hotel, but with his meddling father sabotaging his business plans, they have to keep their arrangement strictly professional. As in, no kisses. No fondling. And certainly no mind-blowing sex! Yet when their best-laid plans end with an unexpected pregnancy, the rebel billionaire must choose between his bachelor ways or losing Kendall and his baby for good!


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Meet the Vendor- Jennifer Glenn
Looking for a unique and custom piece for your home? You're sure to love the one-of-a-kind, handmade ceramics created by Jennifer Glenn. Although it's only her first season at the market, Glenn says she "loves the sense of community at the market, both among the vendors and the shoppers."
Her love for ceramics started by taking classes during high school and college as a source of therapy that provided balance while she worked towards her chemistry degree. Recently, she has set up a studio in her Osierfield home and has been producing pieces for the past nine months. Currently, she is exploring textures by pressing lace doilies into the clay body. She says " the impression left behind is so lovely and tactile!"
Along with her ceramics, Glenn also sells pasture-raised, non-GMO chicken, turkey and duck eggs. Her chicken obsession started about 6 years ago when a friend gave her 7 hens and a rooster, and it has since grown to nearly 50 hens, a rooster, a turkey, and 3 ducks. She and her husband have converted an old peanut wagon into a mobile chicken tractor which they move periodically to give the chickens fresh forage and bugs to eat, in turn, they fertilize the pastures and give fresh eggs! Her son suggested calling their egg business "More Than A Dozen," because purchasing their eggs goes beyond a simple transaction. It helps support their family farm, keeps money in the local community, contributes to sustainable livestock practices, and raises healthy & happy chickens.
In preparing to vend at the market, Glenn was trying to figure out how to combine the presentation of the ceramics and eggs. That's when she came up with the idea of a chicken-shaped deviled egg tray! They make me smile every time I look at them! You can find Jennifer and all of the vendors at the last market of the summer this Saturday, July 27 from 9 a.m. to noon!


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The man shot and killed during an exchange of gunfire at a unit of Hickory Club Apartments on Hickory Club Drive at 7:15 Wednesday night is believed to have come there to commit a robbery.
The deceased is identified as Michael Wayne Jefferson, 36, of Ames Drive. His apparent accomplice, Taleel Green, 19, of Sioux Terrace Drive, was shot in the leg and is recovering.
Witness statements to this point lead South Precinct detectives to believe that Jefferson and Green showed up at the apartment, pulled guns and tried to rob the residents. Two of them retrieved pistols and opened fire. During the exchange of shots, Jefferson was fatally wounded, Green was hit in the leg, and resident Toddrell Bell, 20, was critically wounded in the chest. Bell's friends transported him to StoneCrest Medical Center in Smyrna before officers arrived.
A search of the apartment revealed more than two pounds of marijuana and cash. The investigation is continuing.
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Feeling hungry at work?
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t:+44 (0) 20 7976 7949
Hard Hat (London) Catering are a specialist London based caterer offering a high quality food service to building sites in London and the South East.
Hard Hat (London) Catering have a proven track record for over 20 years in the construction industry, offering a flexible and reliable service reflecting the needs of our clients, workforce and budgets.
Our on-site catering service is competitive and offers a complete catering experience which includes:
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Everyone was very impressed and enjoyed the food and service provided and we are now looking forward to many more of these function with you!
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A Hypoallergenic Mattress Here in San Diego
Although we spend 1/3rd of our lives in bed, a good night's sleep is often the average American's citizen most overlooked aspect of a healthy lifestyle. There are plenty of reasons for this, including the rise of technological devices that prolong nighttime fun and making work a bigger priority than good rest. There are also numerous other factors that contribute to poor quality sleep and generally limited sleeping hours, not the least of which are allergens. Mold, dust mites, bed bugs, and allergens can all build up and create more than a nuisance in your home. Each of these can put you at risk for a wide range of health problems. Plus, these health problems can often be perceived as having another root cause, and go unattended to.
Fortunately, there is a viable, time-tested solution, and for you San Diegans, it exists right in your backyard. Here at Scripps Natural we offer phenomenally comfortable mattresses that are also hypoallergenic. Come and get a good night's rest and wake up feeling more refreshed than you ever have before. Our hypoallergenic models will effectively create an environment that is more favorable to allergies and overall health.
Organic Oceanside Mattresses
Those who have made the switch from a traditional mattress to a hypoallergenic one are quick to point out the immediate improvements. Gone are the mornings waking up with a stuffy nose, plagued with coughing, watery eyes, wheezing, and sneezing. They report a more restful sleep overall and find themselves better prepared to tackle the challenges of the day ahead.
Organic Mattresses in San Diego
So whether you are a newly christened allergy sufferer or you've been fighting allergies each spring for years upon years, consider the switch to an organic, hypoallergenic mattress. Your body will thank you.
Since 2001 we have been helping customers in San Diego, Temecula, and La Jolla get a better night's sleep. We specialize in a purely comfortable mattress that is engineered without the use of harmful chemicals. To learn more about our mattresses and discover all of the useful accoutrements we have to offer, be sure to visit our website today and have a look around!


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Today´s post is probably going to contradict everything you have heard and believed so far about getting what you want. In this post, I would like to provide you and me, even if for a little while, with a space to rest from all the things we are striving so hard to achieve. Aren´t you tired of the race and the games we are playing with life and ourselves? I can honestly say that I am. Sometimes I persuade myself that I want something really bad and that I won´t be happy until I get it. I think I don´t have to give you all the details about how it goes every time I do this. Basically, I vigorously push and try and then push some more until I drive myself crazy and drive away the very thing I wanted to make me happy. And then, when I finally realize that life is not going to create in my experience something that is not in alignment with who I am, I let go and refocus again on what is important:
Take it step by step, day by day…
When I get overwhelmed by the goal itself, it is usually because I have lost the track of the small steps that can be taken right now. No one told us to become everything we are capable of being right now. And if they did, they were wrong. Every great plan is made of smaller actions and those are made of even smaller ones. The opportunities lie in the little things that are in front of us. So the question is – What can I do right now, to fulfill my heart´s calling? Life won´t provide you with the next step if you have refused to take the previous one. Let´s not forget that life is happening now and even though our vision can seem too glorious to have anything in common with the present moment, it is in the ordinariness of daily life where it needs to be executed. If we are not able to handle small tasks, how are we going to handle the big ones?
Remember who you are
In The lost art of prayer, I explained that we don´t get what we want but we always get a match to who we are. If we are too desperate to get something we smell of hopelessness wherever we go. And that isn´t attractive at all, neither for other people nor for opportunities of any kind. For instance, I remember I had one classmate who was so desperate to get a prom date that he had sent a message to almost every girl in the class hoping that one of us would accompany him. Poor guy tried so hard, but he didn´t probably know that girls talk. So, I assume that you already know how it all ended. This happens when we forget who we truly are and when we lose sight of our own value. From my own experience, I know that if I think I can´t be happy without a certain thing, life will be stubbornly refusing to bring that thing into my life so I can receive a greater gift instead – to learn how to be joyful without the specific condition at first.
Instead of WHAT focus on WHY
We can get so easily caught up in the whole chasing-after game that we tend to forget why we started playing it in the first place. When you are frustrated with the results it is either because you forgot why you are doing it or because you are chasing a wrong thing for all the wrong reasons. Once you find the internal satisfaction and fulfillment your external experience will catch up with it. The best way to let go of the results is to be doing something where we see the value in the work itself and we live for the process instead of for the results. It is so easy to tell the difference between a work made out of love and work made from a place of trying too hard to impress someone else.
What does it cost you?
If your goals cost you integrity, inner peace, sanity or people who were always there for you, it is time to ask yourself, whether it is all worth it. Not all that glitters is gold. Let´s make sure we don´t sacrifice the present moment for an imagined future. Because if in order to reach your dream, you don´t treat people with respect and you don´t find time for those you love and those who stand in front of you, even when you arrive at your destination, it´s going to feel empty. Joy, happiness, and fulfillment don´t wait for you at the end of the journey, you have to bring them along with you.
May your dreams chase YOU,


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8,130-Watt, 420cc, 15 HP Commercial Grade Portable Generator
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The United States Senate took a rhetorical stand against President Donald Trump Thursday, passing a resolution defending the press and declaring that the press is "not the enemy of the people."
This nonbinding resolution passed with unanimous consent by voice vote and was introduced by Sen. Brian Schatz, D-Hawaii, and Senate Minority Leader Chuck Schumer, D-N.Y.
US Senate passes resolution with unanimous consent by voice vote that "affirms that the press is not the enemy of the people" and "reaffirms the vital and indispensable role that the free press serves" and "condemns the attacks on the institution of the free press." pic.twitter.com/WENNrGc6KO
— NBC News (@NBCNews) August 16, 2018
This resolution follows tweets Trump sent Thursday morning criticizing the "FAKE NEWS" media.
THE FAKE NEWS MEDIA IS THE OPPOSITION PARTY. It is very bad for our Great Country….BUT WE ARE WINNING!
— Donald J. Trump (@realDonaldTrump) August 16, 2018
There is nothing that I would want more for our Country than true FREEDOM OF THE PRESS. The fact is that the Press is FREE to write and say anything it wants, but much of what it says is FAKE NEWS, pushing a political agenda or just plain trying to hurt people. HONESTY WINS!
— Donald J. Trump (@realDonaldTrump) August 16, 2018
It's nice to know the United States Senate called off the August recess to stay in Washington and pass virtue-signaling resolutions offered by Democrats to throw shade at the president.
Now how about the senators get to work securing the border and addressing the staggering national debt?
… against the mainstream media's biased reporting, selective facts, and outright propaganda. Sign up now for the daily dose of sunlight you need to disinfect the media's lies. It's free!
Chris Pandolfo is a staff writer and type-shouter for Conservative Review. He holds a B.A. in politics and economics from Hillsdale College. His interests are conservative political philosophy, the American founding, and progressive rock. Follow him on Twitter for doom-saying and great album recommendations @ChrisCPandolfo.
Send tips and hate mail to email@example.com.


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The Dubai 7s ancillary tournament has released its schedule for the Boys U19 bracket, which features a few players involved in the North America HS 7s Series.
The tournament will run November 30 to December 2 in Dubai, UAE, and Pool D includes the North American Lions, a team of top USA and Canadian players put together out of performances in the NAHS 7s - mostly the NAI 7s.
The Lions squad can be seen here.
The NA Lions will play against Olymp, KZN Barbarians, and Centurion Warriors. The event features several very strong select teams from Africa and Asia. The Celtic Barbarians, a Canadian team also active in the NAHS events, is also in Dubai. There is also a team from Brussels which is pretty close to a Belgium national team.
RC Olymp is from Ukraine, KZN Barbarians are KwaZulu Rugby from South Africa, and Centurion is also from South Africa.
Here is the Pool Play Schedule (Dubai, remember, is 4 hours ahead of UTC/GMT).
Tag(s): News


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Gene Therapies for Blinding Eye Diseases
Clinical Updates and Access for Canadian Patients
Now that gene therapy is a reality, there is tremendous growth in the world of gene therapies for blinding eye diseases!
What is a gene therapy?
A gene therapy is a new kind of treatment that works by delivering a functioning copy of a gene directly into a patient's cells. This newly introduced, functioning gene acts as a treatment by replacing a gene that is not working properly. After just a single treatment, gene therapy has the potential to provide lifelong benefits.
Gene therapies are poised to transform healthcare by making personalized medicine possible. Although scientists are working on gene therapies for many different diseases, some of the most rapid growth is in inherited retinal diseases.
Inherited retinal diseases, or IRDs, is a term that is used to describe a diverse, rare group of eye diseases. Each IRD is different, but they all share two common traits: 1) they result in progressive retinal degeneration that leads to severe visual impairment or blindness; and 2) they are "inherited," which means that they are caused by one or more genetic mutations that are inherited from the DNA we receive from our parents. Today, more than 250 genetic mutations have been identified as causes for IRDs. Some of the more common IRDs include retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardt disease, choroideremia, Usher syndrome, X-linked retinoschisis (XLRS) and achromatopsia (ACHM).
The chart below highlights ongoing gene therapy clinical trials for IRDs and provides contact information for clinical trials that are accepting Canadian patients. To learn more about the basics of clinical trials and to better understand key terms that are used in the chart (for example, Phase 1 and Phase 2), make sure you read our FBC Primer on Clinical Trials.
ONGOING GENE THERAPY TRIALS FOR INHERITED RETINAL DISEASES (IRDs)
|Inherited Retinal Disease (IRD)
|Clinical Trial Information (NCT# is the number in clinicaltrials.gov database that can be used to search for additional details)
|Contact details for clinical trials that are currently accepting Canadian patients
|Leber congenital amaurosis (LCA) is an early-onset disease caused by mutations in any of at least 16 genes.
|Multiple clinical trials, funded by different sponsors, have evaluated the safety, tolerability, and efficacy of a single subretinal injection of an AAV vector expressing human RPE65 in patients with LCA2. The first RPE65-based gene therapy received approval in December 2017.
|To be determined
|X-linked retinoschisis (XLRS) is characterized by schisis ("splitting") of the retinal layers and reduced visual acuity. XLRS is caused by mutations in the RS1 gene, which encodes the retinoschisin protein.
|Two Phase 1/2 clinical trials are currently studying the safety of an intravitreal injection of an AAV vector expressing human RS1 in XLRS patients.
|To be determined
|Applied Genetic Technologies Corporation (AGTC) is conducting a multicenter, open-label, two-stage dose-escalation trial (NCT02416622).
|The National Eye Institute (NEI) is conducting a single-center, open-label, single-stage dose-escalation trial (NCT02317887).
|To be determined
|Achromatopsia affects the cone photoreceptors and is characterized by severe sensitivity to light, reduced visual acuity, and loss of colour discrimination. 6 genes are known to cause achromatopsia; about 75% of cases are caused by mutations in either the CNGB3 or CNGA3 genes.
|University Hospital Tübingen and Ludwig Maximilian University of Munich are conducting a Phase 1/2 single-center, open-label, single-stage dose-escalation trial for CNGA3 (NCT02610582).
|To be determined
|AGTC is conducting two, Phase 1/2 multicenter, open-label, two-stage dose-escalation trial for CNGB3 (NCT02599922) and CNGA3 (NCT02935517).
|Applied Genetic Technologies Corporation (AGTC) is enrolling Canadian patients – contact Dr. Jill Dolgin at firstname.lastname@example.com to learn more.
|X-linked retinitis pigmentosa (RP) is the diagnosis of approximately 10-20% of RP cases. More than 70% of X-linked RP cases are caused by mutations in the RPGR gene.
|AGTC is conducting a Phase 1/2 multicenter, open-label, two-stage dose-escalation trial to evaluate the safety and tolerability of a subretinal injection of an AAV2 vector expressing human RPGR with a mutation in the ORF15 section of the gene (NCT03316560).
|Applied Genetic Technologies Corporation (AGTC) is enrolling Canadian patients – contact Dr. Jill Dolgin at email@example.com to learn more.
|Stargardt disease is an inherited macular dystrophy characterized by reduced visual acuity that may begin in late childhood. Stargardt disease is caused by mutations in the ABCA4 gene.
|Sanofi is conducting a Phase 1/2 open-label dose-escalation trial (NCT01367444) to evaluate the safety and tolerability of a subretinal injection of a lentiviral vector based on an equine infectious anemia virus (EIAV) expressing human ABCA4 in patients with Stargardt disease.
|To be determined
|Usher syndrome type 1 is associated with profound deafness and early-onset retinitis pigmentosa. More than half of Usher syndrome cases are type 1B and are caused by mutations in the MYO7A gene.
|Sanofi is conducting a Phase 1/2 open-label dose-escalation trial (NCT01505062) to evaluate the safety and tolerability of a subretinal injection of an EIAV-based lentiviral vector expressing human MYO7A.
|To be determined
|Choroideremia is an X-linked retinal disorder caused by mutations in the CHM gene, which leads to progressive constriction of vision and eventual total blindness.
|Six clinical trials, funded by different sponsors, are under way or complete, each evaluating the safety, tolerability, and therapeutic potential of a subretinal injection of an AAV vector expressing human CHM.
|To be determined
|NightstarX Therapeutics just announced the initiation of the first Phase 3 clinical trial (the STAR trial) to study safety and efficacy in patients with choroideremia.
NightstarX will be enrolling Canadian patients at two different sites in Canada; if you live in British Columbia, contact Aleksandra Kuzmanovic, Clinical Research Coordinator, Phone: 604-875-4253
Contact details for the Montreal site will be announced soon
|Leber hereditary optic neuropathy (LHON) is associated with central vision loss and characterized by degenerated retinal ganglion cells. More than 90% of cases are caused by mutations in one of three mitochondrial genes—ND1, ND4, and ND6
|Two clinical trials are currently enrolling patients, including a Phase 3 multicenter, double-masked, controlled trial by GenSight Biologics (NCT02652780) and a Phase 1 single-center, open-label, dose-escalation trial supported by the NEI and conducted at Bascom Palmer Eye Institute (NCT02161380).
|To be determined
|Late-stage IRDs when most photoreceptors have been irreparably damaged or lost, regardless of any specific disease-causing mutations.
|Optogenetic therapy is an emerging gene therapy-based technology in which light sensitivity is introduced into cells that do not normally detect or respond to light. Current efforts in the retina field are focused on delivering the light-sensitive green algae protein channelrhodopsin 2 (ChR2) intoretinal ganglion cells.
|To be determined
|RetroSense Therapeutics and the Retina Foundation of the Southwest are conducting a Phase 1/2 single-center, open-label, dose-escalation trial of this therapeutic approach in patients with advanced RP (NCT02556736).
|To be determined
|AGTC and Bionic Sight are also collaborating to develop a new optogenetic therapy aimed at restoring normal neural signaling in patients with visual deficits or blindness due to retinal disease.
|To be determined
|Clinical Trial of Gene Therapy for the Treatment of Leber Congenital Amaurosis (LCA) (OPTIRPE65)
|Natural History Study of Patients With Leber Congenital Amaurosis Associated With Mutations in RPE65
Kellogg Eye Center
Ann Arbor, Michigan, United States, MI 48105
Contact: Adrienne Chen
|Gene Therapy for X-linked Retinitis Pigmentosa (XLRP) Retinitis Pigmentosa GTPase Regulator (RPGR)
MeiraGTx is conducting an open-label Phase I/II dose-escalation trial to determine the safety and efficacy of subretinal administration of AAV2 vector expressing RPGR.
Kellogg Eye Center
Ann Arbor, Michigan, United States, MI 48105
Contact: Adrienne Chen
|Natural History Study of Patients With X-linked Retinal Dystrophy Associated With Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR)
Kellogg Eye Center
Ann Arbor, Michigan, United States, MI 48105
Contact: Adrienne Chen
|Gene therapy for achromatopsia (CNGB3)
|Gene therapy for achromatopsia (CNGA3)
MeiraGTx is conducting an open-label Phase I/II dose-escalation trial to determine the safety and efficacy of subretinal administration of AAV2 vector expressing CNGA3
|Contact details for the Toronto site will be announced soon
This chart was last updated on August 5, 2019.
This growth in the clinical trials landscape is thanks, in part, to the marvelous, long-term research investments that were made by Fighting Blindness Canada and by the many other organizations that we collaborate with around the world, including the Foundation Fighting Blindness in the US. And of course, thanks to incredible donors, so much is being done to drive the development of new treatments.
These clinical developments are very exciting, especially for our long-term, deeply committed supporters who have been with us since 1974, when we were first established.
Thanks to our supporters, FBC helped to fund Canada's first ocular gene therapy in Edmonton, Alberta under the leadership of Dr. Ian MacDonald. We are passionate about accelerating the development of new treatments, which includes connecting patients to clinical trials that might be a good fit.
If you think that you may be interested in learning more about one of these clinical trials, we encourage you to contact the trial site, to talk with your eye doctor, to seek a second opinion, to reach out to us and to talk with your family. Remember to enroll on the FBC Patient Registry to ensure that you learn about new clinical trial opportunities.
Important tips to remember before searching the clinicaltrials.gov website: If you search on the website clinicaltrials.gov, you can find many gene therapy clinical trials, and other kinds of trials, that are currently recruiting patients to participate. Searching this website can be a good place to start your research, but we must emphasize that this is just a place to start, not a comprehensive or reliable tool. Unfortunately, many of the trials listed on this website have not been approved by the FDA, which means that they may not meet basic safety and ethics standards. This warning is noted on the clinicaltrials.gov website. We emphasize this warning because research has shown that rogue companies are using the clinicaltrials.gov website to "sell" their unproven "treatments" to patients who are willing to pay almost anything because they hope it might work. Always consult with your doctor before participating in potential trial.
Lam, B. 2017. Update on Gene Therapy for the Treatment of Hereditary Retinal Diseases. Retina Today. April, 2017.
Moore, N. et al. 2018. Gene therapy for inherited retinal and optic nerve degenerations. Expert Opinion on Biological Therapy 18: 37-49.
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Mathematics > Combinatorics
Title: The Elementary Divisors of the Incidence Matrices of Skew Lines in PG(3,p)
(Submitted on 14 Jan 2010)
Abstract: The elementary divisors of the incidence matrices of lines in $PG(3,p)$ are computed, where two lines are incident if and only if they are skew.
Submission historyFrom: Peter Sin [view email]
[v1] Thu, 14 Jan 2010 20:41:33 GMT (7kb)
Link back to: arXiv, form interface, contact.


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The summer honey-crop has been harvested last week, and I am busy processing and preparing the honey to be ready to sell. This involves skimming the impurities…… Read more "Pear-rhubarb turnover-cake with honey"
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Blueberry crumble cake
I normally don't use blueberries in cakes or pies, but I wanted to give this recipe a try. It isn't a very high-maintenance cake, you don't have…… Read more "Blueberry crumble cake"
Recipe: Mango-coconut pie using duck eggs
I finally found some coconut flour for sale in my area and I immediately wanted to use it in something delicious. I stumbled on this recipe in…… Read more "Recipe: Mango-coconut pie using duck eggs"
Apple cake squares with honey
This one is the easiest and quickest apple cake recipe I have. You can use a baking tin, but if you dress a deep standard oven tray…… Read more "Apple cake squares with honey"


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Maddie Peplum Top
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Ruffle trim details this patterned peplum top. Mockneck. Sleeveless. Shoulder bow. Peplum hem. Back zip closure. Silk lined. About 24" from shoulder to hem. Polyester/acrylic/viscose/wool. Dry clean. Made in Portugal. . Model shown is 5'10" (177cm) and wearing US size 4.
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How much does it cost to add an untrained salesperson to the floor?
I am working on a proposal to ramp up our training program to the next level, and am looking for #'s.
How much business does it cost to have untrained sales staff on the floor in terms of lost revenue?
How much does the average dealer that actually trains spend on training for the employee?
Is there any ROI data?
I have to move beyond gut feelings here....anyone know where I can get researched #s?
Views: 148
For years it has been said that each alesperson that has to be replaced will cost the dealer about $35,000. I would check with NADA to see if that can be substantiated but I have another suggestion. Get the numbers from the dealer.
If they're going to hire a sales person, what will the ad cost? Who will be doing the interview? What is the cost of taking that person away from their job to do that? If it's a manager doing the interviews, how much will be lost on deals that they can't close because they are interviewing?
Training. If they are hiring one person, there will be no outside trainig to start. Two alternatives. Give them to "Five Car" Fred and have them "learn" the ropes or have a manager work with them to show them the proper procedure. If the manager does this, ask the above questions again.
When I am talking to a dealer concerned about the cost of bringing us into do a recruiting/training campaign and theyare concerned about cost, this is what I talk about. In nearly 100% of the cases, a full campaign will cost the dealer far lessthan if they posted on "Craigslist" for free and did it themselves. In additon, people properly trained by a professional trainer tend to stick around longer. That's a huge savings.
Regarding how much a dealer spends on sales training, there are answers all over the park. The sad truth is, when dealers need training the most, they tend to spend the least. The last few years when business was slower, would have been the ideal time. Easier to get the time to do it, more people could attend, and the benefits of getting more deals would always pay for itself.
Use your ROI in reverse. Ask the dealer what they want for an ROI on each salesperson per year. Then ask them what they are willing to invest to get it.
I love that ROI in reverse! Great idea!!!
Michal - There are a couple of true measurements that can be utilized for performance thus creating an ROI for training and retention. The measurements are "cost per guest" and a real simple tool for measuring the "cost of follow up" on traffic. These metrics will help you put your dealership numbers into a spreadsheet that measures the ROI of the sales person. Once you have proven the cost of each customer and the cost for proper follow up - you can present those costs to affirm the value of investing in a sales training program. I can't attach the spreadsheets here but if you email me at email@example.com , I will forward those excel spreadsheets to you.
Congratulations, on attempting to improve your training programs. Sales people are the face of a franchise and need constant improvement training. Here is an article that I wrote for my blog (http://frontlinetrainingteam.blogspot.com/) that talks about specific steps for sales managers' -http://frontlinetrainingteam.blogspot.com/2011/07/sales-managers-st...
Hope some of this works for your team, it has ours.


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Selecting a pair of eyeglass frames says a lot about your personality and style! With so many different frame styles currently available, picking one pair can feel a bit overwhelming. For example, you'll want to select frames in a color that's flattering to your face. If you have a warm complexion, choose frames in light tortoise, brown shades, gold or honey. Cool skin tones need to watch out for frames that can wash out the face and instead choose colors like dark tortoise, silver or black.
Hendersonville Optometrist Shares Secrets for Selecting the Perfect Frames
The most important part is to select frames that are right for your facial shape so you can feel confident while wearing them. Keep the following frame selection "dos and don'ts" in mind when selecting your next pair.
Round Face
DO choose frames that are square or rectangle. These frames tend to appear wider than a round face, which can enhance the quality of your features.
DON'T choose rimless or round frames, which will only accentuate your roundness in an unflattering manner.
Oval Face
DO opt for frames with a strong bridge that are wider than the broadest part of your face.
DON'T wear frames that are more than half of your face; these frames throw off your natural symmetry and balance.
Square Face
DO choose oval or circular frames to soften the angles of your face and create a thinner appearance.
DON'T wear angular or boxy frames; these frames will accentuate the angles of your face and may make your face appear "bulky".
Diamond Face
DO balance out a narrow forehead and chin with frames that sweep upwards or are wider than your cheekbones.
DON'T select a boxy frame or a too-narrow frame that accentuates your cheeks and further draws attention to a small chin or narrow forehead.
Heart-shaped Face
DO balance the width of your forehead and narrowness of your chin by choosing bottom-heavy frames that add width to the bottom part of your face, like round eyeglasses or square glasses that are curved slightly at the bottom.
DON'T wear frames with decorative or embellished tops that draw attention to the forehead.


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South African President Cyril Ramaphosa appointed Edward Kieswetter, a former chief executive office of insurer Alexander Forbes Group Holdings Ltd., as the head of the nation's tax agency.
Kieswetter will be tasked rebuilding skills and trust in the South African Revenue Service after a commission of inquiry found the previous permanent commissioner had effectively "dismantled" the institution through mismanagement and alleged corruption. He starts at SARS on May 1.
Kieswetter was appointed after a committee named by Ramaphosa shortlisted six candidates, including Deloitte LPP's head of tax in Africa, Nazrien Kader, and Mark Kingon, who took over as acting commissioner following the suspension and later dismissal of Tom Moyane.
"Kieswetter emerged as the strongest candidate, based on his past experience as deputy commissioner for SARS between 2004 and 2009," the Treasury said in an emailed statement Wednesday.
During his time at Alexander Forbes, Kieswetter oversaw the company's return to the Johannesburg Stock Exchange in 2014. He was also a senior general manager at Eskom Holdings SOC Ltd., the state-owned power utility, from 1992 until 2000.


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It's official: Raf Simons has a new gig.
Get up to speed on the Chinese fashion industry with these notes on China's top 20 influencers.
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Video: In the latest installment of Morning T, Jane Herman chats with the actress Mélanie Laurent, the new face of an iconic Dior fragrance.
Students are transformed into models at Harvard's sixth annual student fashion show at Lincoln Center.


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"We made our prayer unto our God, and set a watch" Neh. 4:9
That is always the true attitude of those who are called upon to work for God in face of danger. As the work proceeded, the opposition of the enemies of the people, which first expressed itself in derision, passed to ANGER MINGLED WITH CONTEMPT. Nehemiah was conscious of the menace of this attitude to the work he had in hand, and lifted his heart in prayer to his God. An illuminating sentence in the narrative at this point shows how completely Nehemiah had captured and inspired the people. It declares that "The people had a mind to work." Thus the work went forward, until the wall was raised to half its height. At this point the OPPOSITION BECAME FIERCER, and a determined attempt was made by CONSPIRACY TO STAY ITS PROGRESS. With immediateness, and a keen sense of the necessity created by this fact, Nehemiah says, "We made our prayer unto our God, and set a watch." In this method there was neither foolish independence of God, nor foolhardy neglect of human responsibility and precaution. Everything was done to insure that twofold attitude of complete faith in God, and determined dependence upon personal effort, which always makes for success. How often God's workers fail for lack of one or the other of these important elements!


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Just remember that the hard part is already over. Nothing that will happen over the next several weeks will compare to being told you have cancer. I found celebrating the small daily improvements to be helpful in my ongoing recovery. Keep walking when you get home, just do not over do it.
....what John said.."the hard part is over".....Good luck Jeff and we'll see you on the other side..
HI nemo57
Tomorrow is the first day of the healing process. You will be fine. It seems you have a wonderful support system with your family. Let us know how you are doing on the other side, without prostate cancer.


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Брошь "Неразлучные",
Van Cleef & Arpels. — Les Inséparables clip, 1946.
Van Cleef & Arpels. — Oiseaux de Paradis asymetric earrings, 2009.
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Paradis clip. Set with sapphires and Mandarin garnets perched on a delicate emerald and diamond branch adorned with two exceptional blue and orange pear-shaped sapphires.
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text: With pink bollworm turning virulent and posing a serious threat to the interests of farmers, the Telangana government has asked the farmers to terminate the crop before December. It has ordered an intense awareness campaign to educate the farmers to uproot the plants out after third picking. If the crop is terminated by December, it will break the lifecycle of the bollworm population, lessening the risk of the incidence in the next kharif. The kharif season is coming to end as a good number of farmers have completed their second picking. The third picking doesn't yield much produce but some farmers keep the crop, expecting one or two quintals. Telangana has registered a massive increase in cotton acreage this kharif. The acreage crossed the 46-lakh acre mark, about 15 lakh acres more than the normal acreage. Untimely rains and outbreak of pink bollworm have wreaked a havoc, causing extensive damage to small and medium farmers. But the government's report suggest that the spread of pink bollworms is virulent and has breached the Economic Threshold Level (ETL), which could result in extensive damage. "There is an urgent need to educate the farmers on the need to terminate the crop after December in all the cotton growing areas, particularly in Adilabad and Warangal districts," a senior government official said. He wanted the extension officers to convince to remove the crop and go for shredding of the stubbles. "The worms will survive in the stubbles and could transcend to the next crop," he said.


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TD Bank, Marter Avenue Branch - Moorestown, NJ
The TD Bank Marter Avenue Branch in Moorestown offers all types of deposit accounts with competitive interest rates since March 29, 1993. Besides checking on current deposit rates with the Marter Avenue Branch of TD Bank, also check interest rates with other Moorestown banks to find the best CD rates, savings account rates and money market rates.
Branch Deposits on Hand – $179,943,000
TD Bank Contact Information for Marter Avenue Branch Location
Marter Avenue Branch
316 Marter Avenue
Moorestown, New Jersey 08057
Burlington County
TD Bank branch office number: 786
FDIC Certificate Number: 18409
FDIC Branch Unique Number: 252315
This branch provides: Full Service, brick and mortar office
Established: 29-03-1993
Website: www.tdbank.com
Hours of Operation:Monday: N/A
Tuesday: N/A
Wednesday: N/A
Thursday: N/A
Friday: N/A
Saturday: N/A
Sunday: N/A
Open Now: N/A
If you're looking for a loan to buy a house, a car or get a personal loan the Marter Avenue Branch of TD Bank in Moorestown also offers several different types of loans to banking customers. Moorestown, New Jersey has 12 bank branch(es) to choose from and do business with to find the best mortgage rates, auto loan rates or credit card rate.
TD Bank Marter Avenue Branch Frequently Asked Questions (FAQs)
Where is the TD Bank - Marter Avenue Branch login page for online banking?
Access to online banking is available on the www.tdbank.com website.
Are TD Bank - Marter Avenue Branch auto loans available?
Yes, you can find auto loans offered at competitive interest rates at TD Bank - Marter Avenue Branch. You can find the full auto loan rates and terms available online on the www.tdbank.com website.
Where do I apply for a TD Bank credit card?
The TD Bank - Marter Avenue Branch does offer credit cards. For more information, current credit card rates, and to apply for a credit card, go to the www.tdbank.com website.
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You can go into the Marter Avenue Branch of TD Bank and apply for a mortgage loan. You can also see TD Bank's mortgage rates and get approved for a mortgage loan online at the www.tdbank.com website.
Are TD Bank - Marter Avenue Branch online bill payments available?
Marter Avenue Branch customers can pay bills online by setting up your account on the www.tdbank.com website.
Marter Avenue Branch Location of TD Bank at 316 Marter Avenue, Moorestown, NJ
Other Bank Branches in Moorestown, NJ
Beneficial Bank - Moorestown Branch
Branch Banking and Trust Company - Moorestown Branch
Branch Banking and Trust Company - Moorestown Commons Branch
Cornerstone Bank - Cornerstone Bank
Investors Bank - Delran Branch
Liberty Bell Bank - Moorestown Branch
PNC Bank - Moorestown Main Branch
Republic Bank - Moorestown Branch
TD Bank - Moorestown Branch
Wells Fargo Bank - Moorestown Branch


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Xendoo U • Small Business Learning Center
What's the Best Structure for My Ecommerce Business?
5 min read
Xendoo U • Small Business Learning Center
What's the Best Structure for My Ecommerce Business?
5 min read
The legal formation of your new business is one of the first and most important things you must decide on, as it will affect your tax strategy, debt liability and more. Here's our answer to this frequently asked question, with a quick rundown of the structures used by ecommerce businesses.
Sole Proprietorship
Great for: The individual who runs a fairly small business from home, and doesn't want any bosses or partners involved in the operation.
As the name suggests, you are the single owner of the entire business. Whatever money the business earns goes into your personal bank account, and the company's debts are paid from that account as well. The business does not file a separate tax return; its income (or loss) is "passed through" to your personal tax return.
Great for: Friends or family members who want to go into business together.
With this business structure, you and your partner will share the profits and losses, and are jointly liable for the company's actions and decisions. Usually, decisions can't be made without the express consent of all partners. As with a sole proprietorship, the business is not legally separate from its owners.
LLC (Limited Liability Company)
Great for: Ecommerce owners who want to stay independent while protecting their personal assets from the company's legal liabilities.
The big difference between the previously discussed structures and an LLC is that its owners are not personally responsible for the company's debts or lawsuits. For tax purposes, if it is owned by one person the IRS will consider it a sole proprietorship, and if owned by several people it will be considered a partnership. The LLC can choose to be taxed as a C-corporation or S-corporation, but that is not necessary.
Great for: Those who want to scale the business up and raise capital through issuing stock in the company.
A corporation is a completely separate legal entity from its owners; in fact, you are not technically its owner at all, you are a shareholder (even if you own 100% of the shares). If you perform management or other duties for the corporation, you are its employee and get paid a salary, rather than directly taking profits out of the business. You may choose to register as a C-Corporation or S-Corporation.
There are some limitations in what type of ecommerce business structure you choose — if, for example, one or more of your partners is a foreign national. To make a truly informed decision, please discuss the options with your Xendoo tax professional or a legal advisor.


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An evolution in athleisure, this low-cut ECCO ST.1 WOMEN'S SNEAKER takes a casual, retro-inspired design and brings it up to date with ground-breaking performance features. Giving the nod to 80's style with a combination of state-of-the-art ECCO leathers in opposing colours, this sleek sneaker proves it feels as good as it looks with our game-changing ECCO SHOCK THRU and FLUIDFORM™ Technologies at the sole. Lined in breathable textile, it features an adjustable lace-up fastening for a customised fit every time.
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PROPAGANDHI will be releasing their new album entitled "Failed States" on September 4th, 2012 via Epitaph Records.
PunkNews you an exclusive first look at the upcoming album at this location. Stream the title track from the album below:
PUBLISHED on July 17, 2012.
UPDATED on July 17, 2012 – title track added


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This product is out of stock
Inspired by sea waves, this striking T-shirt is adorned with wavy tulle inserts and ruffles in an asymmetric design. It is crafted from cotton jersey and comes in a straight fit. Dress it up with a skirt or keep it casual with denim.
Product name: DAMI
Product code: 6971950003002
Distributed by Manifatture del Nord S.r.l. Unipersonale, with registered office in Reggio Emilia (Italia), Via Mazzacurati n. 6, 42122
Jersey fabric 1: 100% cotton; Jersey fabric 2: 100% polyester.
Wash by hand in water. Do not bleach. Iron at max. 110 °C using a damp cloth between the iron and the fabric. Delicate dry clean with perchloroethylene. Do not tumble dry. Flat drying in the shade.