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Greeley woman dies from West Nile
August 6, 2003
A 77-year-old Greeley woman's death from the West Nile virus cast a pall as health officials Tuesday released even more bad news: The number of human cases in Weld more than tripled in one day.
Maria Flores died Friday as a patient at Hospice and Palliative Care of Northern Colorado Inc. Inpatient Unit at North Colorado Medical Center in Greeley. She is the fourth person nationwide to die of West Nile this year.
Officials Tuesday confirmed 38 human cases in Weld County – the last known number was 10 – and more are probably on the way: The state has confirmed 72 total cases in the state, but 138 people have tested positive for the disease. Not all of those 138 cases
have been confirmed. Occasionally, people who don't have West Nile test positive for various reasons.
With more than two months left in the mosquito season, Weld has more than half of the state's confirmed cases, though officials don't think the county is any worse off based on mosquito infection rates across the state.
"I wouldn't say Weld is any hotter or colder than any other area," said John Pape, epidemiologist with the state health department who specializes in animal-related disease.
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Even so, he said, Weld's two rivers and acres of irrigated fields to support its agricultural economy probably contribute to the county's high mosquito population.
As the number of those infected continues to climb, residents should take heart in the fact that this is supposed to be the worst year, Pape said. History shows that the second year is always the worst. It's a big reason why Colorado has far more cases than any other state. States with a lot of cases in their second year aren't having nearly the numbers this year, Pape said.
Health officials' voices had an edge to them as they warned residents to take simple precautions, including wearing long clothing and repellent. They've issued those warnings since the spring, until they got tired of saying them, yet many residents are still being cavalier about the threat, said Mark Wallace, director of the Weld County Department of Public Health and Environment.
"This includes the golfers and the hunters and the folks who go fishing," Wallace said. "One mosquito bite is enough to do it."
Weld will take a week or two to search for infection rates among adult mosquitoes and will try to target hot areas, Wallace said, before the county takes other steps such as spraying. Most of the effort, including the $750,000 Weld and its cities spent on controlling the population, have targeted larvae. Now, officials need to find out if they need to start going after adult mosquitoes.
Weld is such a big county that just spraying everywhere could cost millions in a hurry, Wallace said.
Even so, the Board of Weld County Commissioners is prepared to spend an additional hundreds of thousands of dollars, even in a budget already hacked apart by a weak economy, if that's what it takes, Commissioner Mike Geile said.
"We'll have to find the financial resources," Geile said.
Wallace said he believes the mosquito-spraying program has been effective despite the number of human cases in Weld. He said mosquito counts are down in areas that were treated with larvacide. He won't speculate on the number of cases the county would have had without the program.
North Colorado Medical Center has several West Nile patients with severe symptoms, including some with neurological problems.
Re-cent medical data have shown it's hard to recover from those problems, said Jack Breen, infectious disease specialist at NCMC.
NCMC is keeping up with the load of patients and has enough staff to take care of them – so far. Emergency room doctors are watching for West Nile symptoms. The hospital could make extra space available if a lot more patients come.
Even as health officials practically threatened residents to take precautions, they also told them not to panic.
Most who get infected don't even get sick, and those who do get sick get West Nile fever, a mild illness that will probably feel like the flu to those who get it.
One mosquito bite shouldn't scare anyone, Breen said.
"The odds of coming down with severe symptoms from one mosquito bite are astronomically small," he said.
Those with symptoms probably have West Nile instead of the flu, Breen said.
"It's not flu season," he said. "It's West Nile season."
And that's OK. In fact, even those who have mild symptoms probably don't need to call their doctor, Pape said. There is no cure, but those who are sick should use the flu cure of plenty of fluids, pain medication and rest. Most should feel better in a few days.
Those 50 and older do tend to be more severely affected by the illness. The average age of those with severe symptoms across the country is 55, and those who die tend to be about Flores' age, 77.
That may be because you can't catch West Nile again once you get it, and more start to build an immunity to it as the summer goes on.
Health officials were cursing the weather even as they refused to speculate on how many cases could erupt. The wet spring and hot summer have created perfect conditions for a lot of mosquitoes.
"You could not have designed a better summer for mosquitoes," Pape said. And then he sighed and shook his head.


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Ryan Nguyen is an Australian-born colorist and digital imaging technician. He first got started with post-production from online editing and motion graphics, before falling into the rabbit hole that is digital cinematography. He runs Huephoric, a small color grading shop based in Houston, TX.
Most of the company's finishing portfolio is comprised of commercials, music videos, and narrative film. In addition to grading, Ryan has repurposed a camera cart for on-set data wrangling, color management, and light-duty transcoding.
Describe Your Setup
The heart of the DIT cart revolves around a Macbook Retina Pro- it sits atop a 4U rack-mount chassis, which houses a UPS, RAID, and a power distribution panel. All my cables, adapters, and readers sit in separate cases for easy access and storage. On the software side, I use ShotPut Pro to verify and log my offloads, and use Mikael Lubtchansky's FoolKat for generating camera reports. For the bigger jobs that require it, Pomfort Silverstack comes into play. And of course, a toolbox full of utilities related to file, metadata, and workflow.
As you know, the world of DIT is a fast and ever-changing landscape, so I'm always looking forward to adding more monitors, converters, and components to the load out. Part of the beauty of it all is its scalability; the kit is entirely modular and can be customised for specific production scenarios.
How are you running ScopeBox? How are you getting the signal into the software?
ScopeBox runs wonderfully (and exclusively) on the Mac platform. For both grading at the suite and monitoring on-set, the Macbook itself powers the software and ingests the signal through a BlackMagic Ultrastudio Thunderbolt device. It may come directly from camera, piped through a recorder or connected wirelessly to a clean loop-through further upstream.
What is your default ScopeBox palette layout and why?
This is a good opportunity to briefly talk about the strength of ScopeBox. At the limit of your monitor resolution and compute power, the entire screen can be divided up and sectioned off in an infinite amount of ways for your immediate monitoring needs. Each scope further has its own distinct settings as well; it's incredibly flexible and responsive. You can save out your layouts, and call them up with a keyboard shortcut.
Right now, I have a custom layout built for grading at the suite, one for greenscreen shoots, and another for exposure and focus assist during shooting. All of these layouts feature the luma waveform, RGB parade, vectorscope, HML balance, and histograms. For me, these are the most basic core palettes for critical image evaluation. All of these tools used together help me quickly assess the visual profile of the shot, and allow me to monitor channel clipping and gamut excursions in real-time as the shot is being set up. This is done all within context, of course; some creative choices celebrate over/under-exposure, or heavy color casts.
How do you like to use scopes in coloring? What problems do you find yourself turning to your scopes for most?
Our eyes aren't meant for objectively analysing color and exposure on the basis that they are biologically superior to cameras. Throw in uncalibrated displays and uncontrollable viewing environments to the mix, and it's anybody's game. Having scopes is tangibly essential, and sending a thumbs up to the DP after a quick glance at Scopebox makes for all the difference.
What challenges do you see coming up more in the future / how do you think scopes and cc will change in the next 5 years?
I would say the next big challenge with scopes over the next 5 years will have to do with HDR. In the pursuit for wider gamuts, higher dynamic range, and deeper bit-depths, the underlying technology of scopes will have to adapt to these new developing standards in order to properly measure and reflect the integrity of a video signal. Despite our imminent departure from the traditional constraints of Rec. 709, it is my firm belief that the fundamental need for these instruments will forever remain.
Where can people find you online?
You can keep up with my most recent doings at huephoric.com and facebook.com/HuephoricHTX, and peek at more photos here at instagram.com/viewmastery.
ScopeBox Setups is a new series of blog posts where we ask ScopeBox users to send in a photo of their suite and answer a few questions about how they've setup their workspace. If you'd like to be highlighted for the series, get in touch!


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Art Showcase
If you experience any problems placing your order online, please call 800-850-1776 to order by phone.
The Art of Mort Künstler / The American Spirit / The Old West
Here you will find a pictorial chronicle of the drama and excitement of American History. These paintings give the viewer an insight into the tumultuous life of this young nation that mere words cannot achieve.
Limited Edition Print
Paper Prints
Reproduction technique: Fine offset lithography on neutral pH archival quality paper using the finest fade-resistant inks.
Each print is numbered and signed by the artist and accompanied by a Certificate of Authenticity.
Image size: 18 x 14-1/2
Overall size: 22-1/2 x 18
400 Limited Edition Signed and Numbered, Issue Price $100.00, Release Date 2004
40 Artists Proofs Signed and Numbered, Issue Price $150.00, Release Date 2004
Mort Kunstler's Comments
The most popular image of the native American is that of the Sioux warrior wearing a long, feathered war bonnet. Chief High Horse resulted from a trip I took to the Rosebud Sioux Reservation in South Dakota, and it is a depiction of a Sioux in his traditional dress.


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Sample Five-Year Budget for Proposed Charter School in CT
A few weeks ago, Jacquline Rabe Thomas reported that five private operators had submitted applications to CT State Board of Education (SBOE) and CT Department of Education (CSDE) to create and operate new charter schools in Connecticut. This year, the applications for new charters would directly impact two suburban/rural towns, Danbury and Winchester, and two cities, Hartford and Norwalk. These applications can be viewed as a sales pitch by private education entrepreneurs attempting to get State government to shift public dollars to their charter school ventures.
Unlike previous years, there are some changes to how new charter schools get approved. Rabe Thomas noted that a recent change in the law required that the SBOE and CSDE call for applications for new charter schools on a yearly basis. However, there is no requirement to actually create any new charter schools. Also, the State Board of Education only recommends the creation of new charter schools through a "certificate". Then the State Legislature has the final say on creation and funding of new schools. At least one reason for these changes came as a result of charter school entrepreneurs advertising for new charter schools that had not even been funded by the legislature, which placed legislators against parents that were promised a new school that did not yet exist.
In any event, it will be interesting to see what the SBOE and CSDE do given what we are learning about charter school issues and problems. For example, the NAACP has called for a national moratorium on charter schools because of excessive disciplinary practices, mixed records of achievement, siphoning resources away from traditional public schools into private ventures, and continuing segregation by race and ability. You can learn more about that charter school moratorium here.
Reviewing these applications could be a daunting task given the amount of information presented in the five new charter school applications, which are several hundred pages in length. In addition to reviewing these long applications, there is also a context of financial strain. There is no State budget (as of 10/3/2017) and there is lack of consensus about the method of funding for public education and charter schools. Below you can take a look at the new charter school applications and find out what these entrepreneurs are trying to sell to the public this year.
Source: Connecticut State Department of Education.
Community First Charter School – Hartford
Danbury Collegiate Charter School
Danbury Prospect Charter School
Norwalk Charter School for Excellence
Winchester Academy Charter School
Winchester Academy Charter School (appendices)


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I've been playing basketball for sixteen years now, but it wasn't until this last year, while playing pick-up at a gym in New Jersey, that I became cognizant of the phenomenon. It had been present the whole time, to my mind's neglect, but I finally saw the pattern that emerged each time I laced up the sneaks. I'll explain through a brief situational narrative:
Game 1: It's my turn to partake in the five-on-five pick-up bout; I'm playing with four guys I don't really know that well. The game starts and I'm immediately glad to be on a team comprised of such willing passers, who know how to screen away and move effectively without the ball. If you didn't know any better you'd think we were out there playing in front of a coach who holds the key to each of our minutes. There is no place for Carmelo Anthony on this team: our united fluidity erases any chance for black-holing or ball-deading. The ball is moving constantly, always finding the open man. When one of us scores, we all score. Defensively we are tethered to one another, moving properly depending on where the ball shifts. Our defense feeds on our offense, and vice versa. To nobody's surprise we win that game easily.
Game 2: It's more of the same. The fluidity, the unison, the unselfishness. Oh, maybe once or twice someone will hoist up an ill-advised shot, or dribble for longer than is necessary, but it's nothing we can't handle as a fortified team. And so we win this game too, though by less than the game previously.
Game 3: You're waiting for the turn and here it is. During the third game something palpable shifts in our team chemistry. The seal of unity has been exposed, and unleashed from the envelope are all the things we silently swore against earlier: black-holing, ball-deading, putting up bad shot after bad shot. Suddenly someone's trying to dribble out of a double team rather than pass to the open teammate. When we don't have the ball in our hands we become listless spectators, refusing to move to the open spaces on the floor. Defensively we've really started slacking, taking plays off, not boxing out, not helping when help is required. The invisible tether is languishing. Miraculously we scrape by the other team and live to play another game.
Game 4: "Unity what? How do you spell it?" "U-N-I--" "Sorry, the only letters I'm familiar with are M-E," say each of the five Carmelos battling with one another for rights to whack off with the basketball in hand. It's a solo mission at this point, pathetically disguised as five-on-five basketball. Whoever gets the ball in the backcourt is going to throw it up on the offensive end, no matter if s/he's double or triple-teamed. A pass will occur if and only if it's in the form of a dazzling assist, and insofar as the credit falls upon the passer and not the scorer. We've all taken permanent leave from defense; the other team is scoring at will now. The outcome is predictable: our reign is through; we've been supplanted by a team that looks awfully similar to how we looked three games prior. It's kill or be killed and the basketball gods have seen enough to smite us from their court.
We're all familiar with "Kill or be killed." It's the maxim that's said to govern the animal kingdom with grim immutability: "If you ain't first you're last"--or worse, a bloody carcass, that which we humans might call "dinner." If the lion doesn't strike against the tiger, well then the tiger will happily do the honors. We've humanized the literal, turning it into a metaphorical guideline by which to live: strike at or be struck at; screw or be screwed. But in many cases we're actually fine with the literal, and we pop someone's head off or bomb an entire village to ode nature's most ruthless maxim.
Well I'll say it flat-out: it is the most outrageously stupid maxim we've come up with in however many thousands of years human beings have been coming up with rules for self-governance. (The 10 Commandments are in close contention for the top spot.) Let me clarify: for the animal kingdom I think "Kill or be killed" is okay. I've got no qualms with animals adhering to this principle. But as much as homo sapien falls under the primate umbrella, which falls under the mammal umbrella, which falls under the animal umbrella, you and I both know we're a different class of animal altogether. We are the pinnacle of evolution, its redoubtable acme, what with our superior bipedalism (the ability to move by means of our two rear legs), opposable thumbs, and most importantly, our ability to conceptualize our own existence. I think there are other animals who possess the latter, but not to the level human beings have attained. We know consciously that we are alive. And we know consciously that we know consciously that we are alive. And we know consciously that we know consciously that we know consciously that we are alive. And... I think you get the picture. (And if you don't, then I'm suspecting whether or not you really or one of us...) In a single word: reason. It is our exquisite ability to reason that separates us from every other organism on the planet. And it is specifically this distinctive, one-of-a-kind ability that should expunge any need to abide by "Kill or be killed." Why? Because we are now past the survival checkpoint in our evolutionary timetable. Reason and rational thinking have delivered us there. The rest of the animal kingdom, however, is still stuck in the mire. They max out at "Live another day." Not us. We have the remarkable capability--OPPORTUNITY--to choose the quality of our lives. Mind you, this is an extraordinary power that we take for granted, without a moment's thought about the uniqueness of it all. The phrase "quality of life" presupposes that we've got (for the most part) survival taken care of. Animals subscribe to "Kill or be killed" because they have no choice. We do! And we exercise this built-in machination of choice all the time: we can eat half our burger and request the other half in a to-go box (not saying that it's easy); we can skip out on parties and bars in favor of studying or saving money; we can hold in our pee and our poop! In short, we can actively go against our own instinct, especially to benefit us in the long run. For this reason we are not eternally subjected to "Kill or be killed." Or, as would be put in Conversations with God, we are until we're not. In other words, until we decide it's time to choose something else. Something that serves us better, like "No more killing," or "Unconditional peace and love," or how about "We are all one"?
Of course, most everyone has consciously or subconsciously already tried chucking "Kill or be killed" out the window. There's just one problem: it's a feisty little shit and boomerangs back into our cell structure no matter how often we try chucking it, no matter how far we try chucking it. The sad reality is that, up until now, the maxim has not left us fully. I think this is why we battle internally with issues like homelessness: helping or neglecting those begging for money on the streets, because they arouse both our natural love (the desire to help) and our learned fear (the safe bet to neglect). I once learned a fantastic acronym for the word "fear": False Evidence Appearing Real. When we shrink into survival mode, it's always fear-based, and nine times out of ten unjustified. It's that false evidence appearing real, so we revert back to instinct: "Me-first"; "Everyone for him/herself"; "Kill or be killed." It's like we're out there on the basketball court with eyes that elect only to see the opponent. We're out there playing one on five.
All this loops us back to the social experiment of pick-up basketball. What catalyzes the Hyde and Jekel transformation between Game 1 and Game 4? And how do evolution and "Kill or be killed" feature into the experiment? Well, let's have a closer look, shall we?
When five people who don't know each other, or know each other just barely, play on the same team, trust is usually no more trust than it is an exacto knife, or the symbol for Boron. Which makes it all the more remarkable that they'll usually come out of the gates playing like quintuplets in a womb, sharing unselfishly, laving in the glory of the united team. My theory is this: natural law dictates that human beings are unconditionally loving and trusting, when they are ranks above survival mode. When the pick-up game starts, these five individuals are creating from a blank canvas. There is nothing yet to survive; no false evidence appearing real, so they act in accordance with natural law. But this usually doesn't last for very long. At some point one of the five players begins to diminish "us" in favor of "me"--and almost always it's F.E.A.R. fomenting this change in paradigm: someone else taking a bad shot, keeping the ball in his/her possession for too long, erring too much, etc. The descension from "us" to "me" is the descension from boundless living to mere surviving. This person feels endangered, which is, of course, an absurd and fallacious notion. Nevertheless he has achieved metamorphosis from Lebron James (or my main man J-Lin, holla!) to Carmelo Anthony. He has already predetermined to shoot the ball the next time he gets it, no matter what. He does this a couple of times, and how do you think his teammates respond? Voila. Their F.E.A.R. bursts into being. "This guy is being a ball hog," say the other four players. "If he's gonna keep shooting every time he gets the ball, I will too." It's usually a subconscious declaration, and as simple as that the crumbling domino effect has spawned, to the inevitable and ultimate demise of the team.
It always happens like this. If one teammate is ball-deading every time he touches the ball, the other players rarely will continue their marked distributing. Instead they follow suit; the cancer spreads and paralyzes the unselfish movement that had benefitted the team as a whole earlier. "We are all one" is now "Kill or be killed," "Get mine before he gets his."
This is the metaphor I spoke of earlier, informing humanity of its learned nature. F.E.A.R. assails our best intentions, our natural proclivity to love and to share and to live together like muhfuckin' gangstaz. It activates survival mode, causing me-first hatred, jealousy, greed, etc. It makes insects out of natural giants, mortals out of gods and goddesses, and I guarantee you this: it is the single biggest fallacy we continue to believe in on planet Earth. There is no promise in "Kill or be killed" but what we've already got on the table today: war, starvation, poverty, genocide, rape--all stemmed from F.E.A.R. If you play one on five what do you think is going to happen?
It's hard to see in the short term but giving to others from your own stash of possessions is the best thing you can do for yourself. The haves should be giving to the have-nots enough so that everybody has. Hatred is not borne from nothing; I think it's the bitter response from the Self feeling incomplete. If everybody in this world had a home and had enough to eat and could live day-to-day decently (which is entirely possible), don't you think a vast majority of the violence and hatred would cease? If we really got that we are all one, wouldn't the bombs stop dropping in the Middle East? On a smaller scale, wouldn't your own daily problems start to dissipate? I'll quote from Conversations with God directly this time: "Live simply, so that others may simply live."
I think it's possible. Inexorably improbable, no doubt; but humanity has moved mountains before. This one here is the Everest of them all. So what would it take? First is recognition. That is always the first step to ameliorating any problem. If you can't see it, how do you expect to change it? Understand deeply when you're on survival mode, rather than live-like-a-muhfuckin'-g mode; when your mind is being about "Kill or be killed" and not "We are all one"; when you're playing one on five with four teammates listlessly watching while you screw up. Once you can recognize these distinctions you get to do something profound: make a clear and conscious choice at the fork. Do I want to keep living in my narrow shell to just get by, or do I want that planetary experience with all my human kin? Then you act accordingly. Rinse, lather, and repeat. Recognize, choose, act, and repeat. For there to be world peace, the whole world's got to get on the "We are all one" frequency.
It's just like in basketball: it only takes one person playing for him/herself to ruin the team. A virus doesn't need to be significant to spread and infect. All five players have to agree that "We are all one" is the most conducive paradigm to team success to hold court. Only one question remains: can we get everybody to agree? That glass-half-empty voice in my head tells me no. But then another voice says, "Fuck that," and gives me the realness in compelling fashion: "What is there not to agree upon? Who the fuck doesn't want world peace? Who the fuck doesn't want that planetary party where the whole world is poppin' bottles, makin' sweet love and dancin' away the night like there was no tomorrow?"


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Ceramic Exploration (for children ages 7+)
with Nancy Blank and Sabrina Kuchta
Day: Saturdays
Dates: November 3, 10, 17 // December 1, 8, 15
Time: 10:00AM - 12:00PM
Location: Pottery Studio
Fee: $30 per class
In this class, we will explore various techniques in handbuilding and wheel throwing. From decorative planters to dragons to mugs, students will learn and experiment with multiple techniques in construction and decoration of functional and sculptural pieces.
All artwork will be bisque fired after each class.
Children under 8 years old will not be permitted to use the ceramic wheels. No exceptions.


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Often these advertisements promote over-the-counter pills, elixirs, sprays, and creams-- claiming to have high amounts of hormone in them. Since hGH must be dispensed by prescription only, none of these products could contain a hint of it.
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The government has drawn a clear line regarding purchasing and using hGH. That's evidenced by the flurry of grand jury indictments, which include the Department of Justice and FDA raids on online drug networks linked to indiscriminate doctors and "anti-aging" healthcare centers.
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Our Elite Program continues to lead the way in the industry by helping thousands of people live life to the fullest again. Our team is ready to help you take your health to the next level!
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Our team is looking forward to providing you with an incredible experience!


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AMovieGuy.com's RATING: 3 ½ STARS (Out of 4)
Skate Kitchen is, as the kids are saying these days, "my jam". The newest film from director Crystal Moselle is a fantastic follow-up to her 2017 documentary hit The Wolfpack. It combines the style of a documentary with the coming-of-age themes in a narrative feature, with a cast of non-actors, and a voyeuristic look that makes it the perfect "hang out" movie for years to come. It also tells a story of female empowerment, friendship, and what it means to grow up in the big city of New York. Skate Kitchen is not just one of my favorite movies of 2018, it is a film that I want to relive again and again.
Our main character is Camille (Rachelle Vinberg), a 19-year old woman, living in Long Island with her single mother. At first glance, one might think Camille is a bit of a loner, but she's actually someone who just needs a chance to fly. She's shy, amazing at skateboarding, and has the passion to back it up. Trying to do a cool trick leads to her needing some stitches in her leg and a stern warning from her mom, but she's not going to be kept down. One day she peruses Instagram and finds a group called "Skate Kitchen", a posse of female skaters, living in mid-town Manhattan, making viral skate videos. Under strict rules from her mother, she sneaks out of the house, locates the group, and they all immediately bond.
It's quite hard to promote a movie like Skate Kitchen. A low-budget film, about women, directed by a woman, and the coming-of-age experience. How can I get you to go see a movie about a group of 18 and 19-year-old's who are phenomenal at skateboarding, have fun chatting about boys, and a genuine love for one another? The answer is you should want to see it and live through different lives. The direction from Moselle is stellar. With cinematography by Shabier Kirchner that captures all of the sights and sounds around the city. The up-beat soundtrack makes us feel alive, as we watch Camille, Kurt (scene stealer Nina Moran), Janay (Ardelia Lovelace), Eliza (Jules Lorenzo), and Kabrina (Kabrina Adams) become true friends. It feels like a reminder of what it was like growing up. No matter what the gender was, I related to the entire experience from beginning to end.
If Skate Kitchen has any flaws it's that it loses a bit of steam in the end as the narrative goes through the dramatic divide, which arises between Camille, possible love interest played by Jaden Smith, and the rest of the crew, but that eventually ties up as a nice expression of the growing pains that we all go through in life. Camille's path from looking for her escape from home and finding out what matters in life, may be predictable, but it's incredibly honest. The final result is one of the most exciting movies of 2018 and the emergence of one of the best directors in cinema today: Crystal Moselle. Skate Kitchen reminds us what it is like to be young. To be free of the stresses of work or paying bills. It's hands down one of my favorite movies of 2018. If you can't stand the heat, go see Skate Kitchen.
Written by: Leo Brady


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Finally, we're back in Italy as of a few weeks ago. And, we're really happy about it.
We had to leave for the summer due to visa reasons. Well, Kamea and I didn't have to leave because we're in the middle of applying for our Italian dual citizenship, but Greg can't apply until I get mine (as my spouse).
Therefore, we had to leave because he couldn't stay.
Obvs, I was eager to get back. Italy is amazing. A little piece of my heart (or, rather, a big piece) was back in Italy while we traveled to Ireland and Bulgaria during the summer months.
And since we've been traveling like nomads pretty much since March of 2018, I'm a little eager to settle down. Now that we're here, we're doing just that.
Update On Our Italian Dual Citizenship Goal
It's progressing nicely. For starters we've been able to get permission from the police headquarters here for Greg to stay while we're processing my citizenship papers. That's a relief because we don't need to come and go anymore from Italy.
The other amaze-balls thing is that my paperwork continues to progress, getting the necessary approvals and verifications along the way. We've only one more approval to secure – the town where my great grandfather was born. They need to verify that he was indeed born there, even though they already sent us a copy of his birth certificate for the application. Mamma Mia!
Meanwhile, we're living up the life in Italy. Indulging in the food, embracing the culture, and taking courses.
This picture pretty much sums it up regarding Italian community culture. Yes, please.
Italian Cooking
I'm back in the kitchen and I'm experimenting with Italian cuisine (yes, that means pasta!). Funny thing, though, as a kid growing up with pasta I would eat a huge plate of it, then find myself noshing on the stuff cold from the fridge in the middle of the night. But in Italy, a serving of pasta is not quite like that.
It's smaller.
So, I bought a scale to serve proper amounts. I also bought a nice pasta pot. You know, a pot with a strainer insert for making pasta? I thought it made sense to buy one.
Well, when I was walking home with my prized possession last week I bumped into my Ukrainian neighbor (they've lived in Italy 11 years).
Always eager to practice my Italian, I told her I bought a pasta pot.
She asked why?
[Read more…] about Back in Italy – Still Working on Dual Citizenship (Italian. Expat Life.)
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Global economic outlook: slowdown, not recession
Global economic outlook: slowdown, not recession
We have revised down our forecast for global GDP growth in 2019 to 2.8% from 2.9%, but increased our projection for 2020 to 2.7% (from 2.5%). The downgrade for this year (the fourth in consecutive quarters) is driven by cuts to our forecasts for the eurozone, UK and Japan which offset a small increase to our China forecast.
In 2020, the upward revision is across the board with, for example, the US upgraded to 1.6% (previously 1.3%), Japan to 0.4% (previously 0%) and China nudged up to 6.1% from 6%.
Meanwhile, our inflation forecasts have been reduced for this year and next with reductions across all regions except Europe. US inflation is also lower as a result of a smaller rise in core inflation (i.e. excluding food & energy prices) which we expect to peak at a lower level before declining in 2020.
Longer-term picture looks brighter
Underpinning these forecasts are a number of factors which give us reasons to be more cheerful about the longer-term outlook:
- Firstly, oil prices are lower. While this is a symptom of weak global demand, it is helping to bring down inflation and boost consumers' spending power.
- Second, the US and China are moving closer to a trade deal. President Trump extended the deadline for raising tariffs on $200bn of Chinese imports from 10% to 25% beyond 1 March. This means tariff increases will now be more limited, helping to reduce costs, protect profit margins and contain inflation.
- Thirdly, monetary policy is easier. This is partly a reflection of lower inflation but it also marks a shift in Federal Reserve (Fed) policymaking where the central bank has become more responsive to financial market conditions.
We now expect the Fed to increase interest rates only once more before they start to fall in 2020 as the boost from tax cuts disappears and monetary tightening feeds through. It seems unlikely that additional fiscal stimulus will be passed by the Democrat-controlled House.
While a trade truce between the US and China could help boost external demand later this year, even as the trade war quietens down the tech war will remain in full swing. We would expect the US to continue to challenge China in this area either through sanctions on Chinese companies or preventing its own companies from exporting key technology items.
Temporary factors have weighed on eurozone growth
We have pushed out rate increases in the UK and eurozone. In the case of the UK, this reflects the growing likelihood that a short delay may be required to facilitate Brexit. Conversely, in Europe, temporary factors have held back growth but we expect the effects to begin dissipating in a few more months.
Among these temporary factors, Germany was impacted by changes to car emissions testing which caused sales of new vehicles to slump sharply from September 2018. Sales have begun recovering. Germany's woes were compounded by a drought that reduced the river Rhine's water levels so significantly that it led to disruption in raw materials shipments.
In the meantime, in Italy political uncertainty caused financing costs to rise across the economy. In the end, the government's expected spending splurge was far more modest than feared and the 2019 budget was approved, albeit after a very public battle with the European Commission.
Given the temporary nature of these shocks, we expect to see an improvement in growth by the summer. Fundamentals are sound in Europe with monetary policy still very loose while most countries have completed their austerity programmes. Following the 8 March European Central Bank meeting, we now forecast a rate rise in March 2020.
- For Azad Zangana's view on the latest ECB meeting, please see ECB's rate rise is likely to hurt banks' profitability
VAT increase in focus in Japan
In Asia, we expect the Bank of Japan to leave monetary policy unchanged. Energy and one-off factors should drive a further moderation in inflation before a VAT-led spike in October, as the VAT rate rises to 10% from 8%. We expect a subsequent sharp decline in demand and dissipating inflationary stimulus. On the other hand, more infrastructure spending for disaster prevention should support growth at the end of 2019, and more substantially in 2020.
China is expected to ease further through a lower reserve requirement ratio which is now forecast at 10% by end 2020 (previously 11%). The ratio dictates the amount of cash banks have to hold in reserve, so a lower ratio frees up more capacity for lending.
The main changes for emerging markets come from inflation. Crude oil prices have fallen dramatically since we last updated our numbers. Combined with surprisingly low domestic inflation this sees substantial downward revisions to the inflation outlook for all BRIC economies bar Russia, for whom cheaper oil means a weaker currency and hence more imported inflation.
Turning to currencies, the US dollar is expected to remain firm in the near term, but to weaken later in the year as rates peak in the US whilst monetary policy tightens in the eurozone and UK. Sterling is also boosted by our assumption that a Brexit deal is struck and the UK enters a transition period after 29 March, rather than crashing out of the EU.
Alternative scenarios
These forecasts represent our baseline case, to which we attach a 60% probability. We also model a number of alternative scenarios. One of these is "Recession excluding US", whereby the outlook in China and Europe deteriorates significantly, while another is "US recession 2020". These two scenarios would both have a deflationary impact on the world economy and we estimate the probability of these at 17%.
We also model three scenarios that would have a stagflationary impact, i.e. causing persistent inflation and stagnant growth. These are "Trade war: US versus Rest of the World", "Global inflation surge" and "Italian debt crisis". We attach a 14% probability to these three scenarios.
We see a lower probability for two reflationary scenarios. In the first of these, "China reopens the spigots", we assume large scale stimulus from Chinese policymakers. In the second, we model a "US supply side surprise" whereby more people enter the US workforce, therefore containing wages and inflation and extending the economic cycle.
Important Information: This communication is marketing material. The views and opinions contained herein are those of the author(s) on this page, and may not necessarily represent views expressed or reflected in other Schroders communications, strategies or funds. This material is intended to be for information purposes only and is not intended as promotional material in any respect. The material is not intended as an offer or solicitation for the purchase or sale of any financial instrument. It is not intended to provide and should not be relied on for accounting, legal or tax advice, or investment recommendations. Reliance should not be placed on the views and information in this document when taking individual investment and/or strategic decisions. Past performance is not a reliable indicator of future results. The value of an investment can go down as well as up and is not guaranteed. All investments involve risks including the risk of possible loss of principal. Information herein is believed to be reliable but Schroders does not warrant its completeness or accuracy. Some information quoted was obtained from external sources we consider to be reliable. No responsibility can be accepted for errors of fact obtained from third parties, and this data may change with market conditions. This does not exclude any duty or liability that Schroders has to its customers under any regulatory system. Regions/ sectors shown for illustrative purposes only and should not be viewed as a recommendation to buy/sell. The opinions in this material include some forecasted views. We believe we are basing our expectations and beliefs on reasonable assumptions within the bounds of what we currently know. However, there is no guarantee than any forecasts or opinions will be realised. These views and opinions may change. To the extent that you are in North America, this content is issued by Schroder Investment Management North America Inc., an indirect wholly owned subsidiary of Schroders plc and SEC registered adviser providing asset management products and services to clients in the US and Canada. For all other users, this content is issued by Schroder Investment Management Limited, 1 London Wall Place, London EC2Y 5AU. Registered No. 1893220 England. Authorised and regulated by the Financial Conduct Authority.


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Filling a Long-Felt Want: The Origin of Playthings Magazine
At the turn of the 20th century, the toy market in the United States relied heavily on European imports—only 30 percent of the toys sold were produced domestically. Retailers and salesmen depended on buyers who traveled abroad for goods and news of industry trends. In 1902, a group of American toy companies sought to change the status quo, stationing themselves in a lower Manhattan hotel for the month of February to entice toy buyers with American-made products as they departed for Europe and arrived home again.
Must-Have Holiday Toys—Past, Present, and Future
Is there someone on your holiday gift-buying list who deserves a memorable toy this season? I'm here to tell you to look no further than the must-have toys of yesteryear to come up with a gift that's sure to delight—a strategy that will spare you from duking it out in the toy aisle over the latest hot plaything that's selling at a premium.
Outlook Good: Magic 8 Ball Inducted into the National Toy Hall of Fame
Documenting the Skylanders Story
It began with a phone call from Paul Reiche III last summer.
Dolls in Focus
In October 2017, I had the chance to be at The Strong National Museum of Play as a research fellow collecting data for my Dolls in Focus project aimed at revisiting and expanding the findings of my previous linguistic investigation on dolls' language. Surprisingly, what I thought would primarily be an exploratory incursion into dolls' universe from an academic perspective turned out to be a rather touching and personal experience that allowed me to revisit my own childhood memories.
Sidewalk Surfing: The Gnarly History of Skateboarding Part II (1973 to 1991)
Sturdily Built: The Playful Longevity of the Cardboard Box.
Examining 21st Century STEM–related Toys and their Impact on Girls
If someone asked you to name the types of toys girls played with, what would you say? Perhaps you would shout out "Barbies" or "baby dolls" or "pink cuddly toys," right? Those types of toys have long been associated with girls, while trucks, cars, and blue toys made from hard plastic have been associated with boys. Meanwhile, the United States is struggling to understand why girls are not attracted to Science, Technology, Engineering, and Mathematics (STEM) subjects.


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Rlogin Ssh
Looking for r ssh login? Find top links for easy and hassle free access to rlogin ssh.
Last Updated: 9th February 2019
Difference Between Rlogin and SSH | Difference Between
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Day 1 :
Keynote Forum
Panayiotis P Constantinides
Biopharmaceutical & Drug Delivery Consulting LLC, USA
Keynote: Development and commercialization of oral peptide and protein therapeutics: Trends and perspectives
Time : 10:00-10:30
Panayiotis P Constantinides is President of Biopharmaceutical & Drug Delivery Consulting, LLC in Gurnee, USA that he founded in 2004, and he has more than 30 years of industrial experience in drug delivery and pharmaceutical development. He did diploma in chemistry from Athens University in 1977 and PhD in Biochemistry from Brown University in 1983. He was a postdoctoral fellow in the Pharmacology Department and Associate Research Scientist in the Comprehensive Cancer Center of Yale University School of Medicine (1983-1987). Past industrial positions held included: Vice President of R&D with DOR Biopharma and Morton Grove Pharmaceuticals (2000-2004), Director of Research at SONUS Pharmaceuticals (1997-2000) and from 1987 to 1997 a number of R&D positions of increasing responsibilities with LipoGen, SmithKline Beecham Pharmaceuticals and Abbott Laboratories. He is inventor in 33 patents and patent applications, has authored more than 130 publications including review articles, book chapters and presentations on the parenteral and oral drug delivery of small molecules and peptides/proteins and has presented more than 100 invited talks at many national and international conferences, pharmaceutical companies and universities. Dr Constantinides is AAPS Fellow, Past Chair of the AAPS Formulation Design and Development Section, the Nanotechnology and Lipid-Based Drug Delivery Systems Focus Groups. He has received numerous honors and awards and serves as Associate Editor of the AAPS Open journal since its launch in the fall of 2015..
The oral route is the most preferred non-invasive route of drug administration due to increased patient compliance. However, advancing oral peptide and protein therapeutics from bench to clinic and commercialization has been a formidable task. Despite major investments and scientific advances in this area over the last three decades, there is no oral water-soluble and poorly permeable (BCS III) peptide/protein drug product on the market. Oral drug delivery approaches used alone and in combination in preclinical and clinical studies include, chemical modifications, intestinal permeability/ absorption enhancers, such as lipids, surfactants, and proprietary molecules, and lipidic and polymeric micro-/nanoparticles with and without targetable ligands directed towards M-cells/Peyer's patches in the intestinal mucosa. Upon introductory remarks on the Biopharmaceutics Classification Scheme (BCS) as applied to peptide therapeutics and characteristics of an ideal oral formulation, advantages and limitations with peptide therapeutics and drug development needs will be presented during the first part of the talk. Then preformulation and formulation development aspects of oral peptides, assessment criteria and development considerations with various delivery technologies will be discussed, followed by lessons learned from preclinical and clinical studies. The last part of the talk will summarize accomplishments to date, address commercialization issues and conclude with future developments in this field.
Keynote Forum
Arwyn T Jones
Cardiff University, UK
Keynote: Activating endocytosis for enhancing cellular delivery and modifying intracellular targeting of therapeutics
Arwyn T Jones obtained a PhD in protein-crystallography at Birkbeck College, University of London and undertook postdoctoral endocytosis research at the University of Liverpool, Harvard University, and EMBL-Heidelberg as EMBO and Alexander von Humboldt fellow. Appointed as a lecturer at the Cardiff University School of Pharmacy and Pharmaceutical Sciences in 2001 he is now Professor of Membrane Traffic and Drug Delivery. His research falls within cancer cell biology, endocytosis, and drug delivery. A major objective understands endocytosis to improve the cellular delivery efficiency of drug delivery vectors including peptides, natural and synthetic nanoparticles and antibodies targeting plasma membrane receptors. Recent work has concentrated on strategic approaches to plasma membrane targeting to stimulate endocytosis and intracellular targeting. He has published widely within these fields and his group has made significant contributions to the current understanding of the way drug delivery vectors interact with cells and enter endocytic pathways that govern their intracellular fate.
Targeting disease processes inside cells with biopharmaceuticals represents a major challenge, not least in overcoming biological barriers such as those posed by the plasma membrane and endolysosomal organelles. Investment in this approach is justified when one considers the number individual intracellular targets now available to us as we continue to understand disease processes at the gene, protein and signaling level. This is true for many high-burden diseases such as cancer, infectious diseases and inherited genetic defects such as cystic fibrosis. Our research at Cardiff University is focused on studying endocytosis and specifically on designing methods to analyze individual endocytic pathways to characterize how Drug Delivery Vectors (DDVs) and associated therapeutics bind to and gain access to cells. As vectors, we have paid particular attention to natural ligands, cell penetrating peptides, antibodies and polymer conjugates. We have made significant contributions to the current understanding of the way DDVs interact with cells, enter cells and traffic on endocytic pathways that critically govern their intracellular fate. This lecture consists of work we have performed focusing on technologies and in vitro models, we have exploited to study cell binding and endocytosis of DDVs including cell penetrating peptides, exosomes, ligand decorated nanoparticles and antibodies targeting plasma membrane receptors on cancer cells. Mainly highlights will be on how we recently demonstrated that Internalisation of receptors, and associated ligands, can be significantly enhanced through manipulating ligand and receptor association, and how normal endocytic routes can be modified to reach a desired intracellular location. Our involvement in a €30M FP7 Innovative Medicine Initiative (IMI-EFPIA) consortium (COMPACT www.compact-research.org) will also be discussed. This represents public-private collaboration between 14 European academic institutes and pharmaceutical companies aiming to improve the cellular delivery of biopharmaceuticals across major biological barriers of the intestine, lung, blood-brain barrier and skin.
Keynote Forum
Prakash V Diwan
National Institute of Pharmaceutical Education and Research, India
Keynote: The pursuit of oral insulin is a reality: Is it simply a matter of when?
Prakash V Diwan obtained his PhD from Postgraduate Institute of Medical Education and Research, Chandigarh, India. Contributed in the areas of Novel Drug Delivery systems & drug discovery. Published over 200 papers in pre-reviewed journals. He delivered guest lectures in India and abroad. He has many awards instituted by Indian Pharmacological Society. He has served as founder Director of NIPER, Hyderabad and fellow of the Royal Society of London, FRSC (London). Presently working as Technical Advisor, Indian Pharmacopeia Commission, Government of India, Director School of Pharmacy, and Hyderabad. Director, CRL, Maratha Mandal Group of Institutions, Belgaum, and Consultant for Indian Institute of Technology, Hyderabad.
Oral insulin delivery has been a promising and interesting research area and can revolutionize treatment. Several studies have achieved positive results which includes nanotechnology. Considerable problems of developing oral insulin are because of the small therapeutic index and short half-life which limits the success. Several insulin delivery systems, such as tablets, capsules, intestinal patches, hydrogels, microparticles, and nanoparticles, have been explored to deliver insulin without much success. Various types of nanoparticles are currently studied for insulin delivery in diabetes treatment such as polymeric biodegradable nanoparticles, polymeric micelles, ceramic nanoparticles, liposomes, and dendrimers. Exubera as the first and until now only inhaled insulin with a market approval, was not a market success due to insufficient uptake in the market. The intestinal micro patches for oral insulin delivery is the well-thought approach. The colon-specific drug delivery system has many advantages. Encapsulation of insulin in vitamin B12-coated dextran nanoparticles has been considered in complementing diabetes therapy by taking advantage of enhanced insulin absorption through vitamin B12 intrinsic factor receptor ligand-mediated endocytosis via intestine leucocytes. Artificial pancreas: The future of diabetes treatment. It's known that intestinal epithelial cells have insulin receptors on their apical surfaces. Researchers think that beta-cell implants or island of langerhans transplants would be a more feasible and perhaps better option? Current research has been going on to deliver insulin experimentally and this has been achieved by the developing "smart" insulin patch. The oral version of an acylated insulin analog with a half-life of ~70 hours is a great breakthrough. The herbal medicines are a symbol of safety in contrast to synthetic drugs. The lifestyle is becoming techno-savvy and we are moving away from Nature. The 80 % of the world population is using herbal medicines. Gymnema sylvestre also increases the amount of insulin in the body and increase the growth of beta cells in the pancreas and many more in the armamentarium of Indian herbal wealth. Most of the developments of these companies have failed in phase II clinical studies, showing insufficient metabolic control in patients with diabetes. However, researchers are concerned that oral insulin could raise the risk of certain types of cancer. Addressing these issues successfully will create a new paradigm in diabetes treatment. Future advance in drug delivery could still make it a reality.
Keynote Forum
Oleg V Tcheremissine
Atrium Health, USA
Keynote: Amyloid hypothesis and drug development for Alzheimer's disorder: A critical review
Oleg V Tcheremissine, MD, is a Professor of Psychiatry, Department of Psychiatry, Atrium Health. He is a board-certified Psychiatrist with 30 years of medical and more than 25 years of research experience in human behavioral and applied clinical psychopharmacology. He has served as a Principal Investigator for numerous pre-clinical and Phase II-IV clinical trials in a range of neuropsychiatric indications. More recently, his research has been focused on developing new insights into neurodegenerative diseases with a primary emphasis on advancing pharmacotherapy of Alzheimer's Disorder and other cognitive disorders. He has successfully combined his research interests with his teaching, clinical, and administrative responsibilities while focusing on eliminating external and internal barriers to novel and innovative treatments with the overall goal of reducing health disparities, improving access to care and increasing the generalizability of clinical trials results.
.Alzheimer's Disease (AD) is a devastating progressive neurogenerative disorder resulting from pathological changes in the brain. AD manifests by a broad range of symptoms affecting memory, concentration, volition, and leading to significant impairment in all activities of daily living. The currently approved pharmacological treatments have only limited efficacy and provide mostly symptomatic benefits as they do not specifically target the underlying pathology of AD. AD pathology is characterized by the accumulation of beta-amyloid protein (Aβ), tau-protein, and associated inflammatory response. The amyloid cascade hypothesis has been the basis for developing an entire new class of disease-modifying therapeutics. In the past 20 years, there have been more than 100 attempts to develop new pharmacological agents, including a wide range of therapeutics targeting different components of the amyloid cascade. Based on their role in the amyloid cascade and the primary mechanisms of action, these new therapies could be divided into three subclasses: a) aimed at reducing production of Aβ; b) aimed at promoting Aβ clearance; and c) aimed at reducing Aβ aggregation. This session will provide a critical overview of the amyloid cascade hypothesis in AD and discuss the future directions in drug development for AD.
Keynote Forum
Edwin G Moore
University of Illinois, Urbana
Keynote: Multivalent polymer conjugate inhibits aggregation of beta amyloid and disassembles amyloid fibrils – potential for a polymer therapeutic
Edwin Moore has 40 years of biopharmaceutical, pharmaceutical, and clinical diagnostic industry experience from global companies, Baxter Healthcare Corp and Abbott Laboratories, in R&D product development. Since retiring he has enjoyed research, teaching, and mentoring startup companies at University of Illinois, Champaign-Urbana campus, and consulting with BioPhia Consulting, Inc. He was a postdoc at University of Michigan, and received his PhD from Cornell University in Biochemistry, B.S. from University of Illinois in Biochemistry.
Beta-amyloid (Aβ) is a member of a class of proteins that are intrinsically unstable. Aβ normally exist as random coil polypeptide. However, the protein will rearrange to the beta-sheet structure resulting in aggregation followed by fibril formation in the brain. Fibrils become the plaques that are observed in Alzheimer's patients. In patients that develop Alzheimer's disease, abnormal levels of Aβ protein accumulate in the brain and aggregate. Aβ protein aggregates and fibrils are believed to be neurotoxic leading to neurodegeneration and cell death. We demonstrated (Y. Song, et.al. JACS, 2014, 136:5233-5236) that a multivalent polymer-peptide conjugate (mPPC) is a very potent inhibitor of Aβ aggregation. The polymer consists of a linear N-(2-hydroxypropyl)-methacrylamide backbone appended with multiple copies of a pentapeptide. As a monomeric strand, this pentapeptide is known to bind to the beta sheet region of the Aβ protein. The enhanced local concentration of the pentapeptide in mPPC dramatically enhances the interference of beta-sheet formation with Aβ. Moreover, mPPC also disassembles amyloid fibrils leaving nanoparticle complexes of mPPC and Aβ aggregates (Y. Song, et.al. JACS, 2017, 139:4298- 4301). Synthetic polymers, like mPPC, represent an untapped class of therapeutic agents. Polymers offer potential benefit as therapeutic agents when designed with specific binding agents and other selective functionality. To realize this potential further research and development is needed to provide discrete chemical entities with defined molecular weights and uniquely positioned functional moieties. Precision polymers are evolving to create a new class of discrete chemical entities to further enhance medical applications.
Keynote Forum
Luke S Fisher
Collaborative Drug Discovery, USA
Keynote: Solutions for collaborative drug discovery: Connecting researchers globally
Luke S Fisher brings twenty years of experience in scientific informatics solutions. Managing Pre-Sales, Post-Sales and working in Account Management has expanded my domain knowledge of scientific informatics and provided me the ability to maintain a successful track record. He have covered a broad range of clients including the world's leading pharmaceutical, biotech, agricultural, chemicals, academic and government labs. He have extensive experience in scientific software solutions from the smaller scale deployment of point solutions like molecular modeling packages to the larger enterprise scale of ELNs, scientific workflow technologies, data content, analysis and visualization. It also includes managing the support complexity of software integration strategies based on numerous mergers and acquisitions.
Collaborative Drug Discovery (CDD) provides trailing innovation for today's chemical and biological data needs, differentiated by ease-of-use and superior, secure collaborative data sharing workflows. Within the CDD Vault® software, activity & registration, visualization, inventory and ELN capabilities all address today's markets. Researchers need to archive, mine, and collaborate around the structure-activity relationships generated from their biological screens. Collaborative hypothesis generation and evaluation allow multiple brains to synergize. In contrast, CDD's Research Informatics Group invents bleeding edge technologies for tomorrow's needs. For example, open source descriptors and model sharing capabilities allow for platform-independent collaborations, even for sensitive data and IP, with groups reticent to share. As a second example, the recently developed BioAssay Express (BAE) technology streamlines the conversion of human-readable assay descriptions to computer-readable information. BAE uses semantic standards to mark up protocols, which unleashes the full power of informatics technology on data that could previously only be organized by crude text searching. These two newer web-technologies may be used not only with the CDD vault but also with non-CDD software tools. Case studies will be shared from a virtual distributed company, government (NIH Neuroscience Blueprint, MM4TB), non-profit (BMGF, MRF, NPDI), and numerous leading academic collaborations.
Keynote Forum
Rodney Villanueva
Atrium Health, USA
Keynote: Minority populations in clinical trials
Rodney Villanueva completed his M.D. at the Uniformed Services University of the Health Sciences in Bethesda, Maryland. He is an Assistant Professor of Psychiatry at Carolinas Medical Center and an Adjunct Associate Professor of Psychiatry at the University of North Carolina School of Medicine. He also serves as the associate director of psychiatry residency training and the psychiatry clerkship director at Atrium Health. He is a strong voice for minority health issues, raising awareness of the health disparities that arise within marginalized communities. At Atrium Health, he has spearheaded efforts at education and advocacy for LGBT health issues, establishing an annual LGBT Healthcare symposium and speaking locally and internationally issues of LGBT mental health.
Notwithstanding the considerable efforts to increase study generalizability and minimize health disparities, the recruitment of minority and underserved individuals in clinical trials across many therapeutics areas remains to be a challenging task. Despite the increase in the number of countries participating in clinical trials used by the FDA to approve of drugs, racial diversity in such trials has not increased. Drug effectiveness and adverse effects can vary according to the ethnicity of an individual patient. However, when the definition of "diversity" is broadened, other marginalized or minority populations are underrepresented in clinical trials, potentially affecting the applicability of the results of the trials to the population as a whole. This presentation will explore the potential causes of poor participation in clinical trials of ethnic minorities, low-income populations, sexual minority populations, and rural populations. The implications of limited diversity, as well as strategies to address these problems, will be discussed in the context of the study design and methodology, and culturally appropriate recruitment strategies employed.


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Mixing device can mix gases and liquids. The use of mixing equipment can increase the solubility of the gas in the liquid, and the concentration of the gas in the liquid is higher, thereby achieving a more desirable use effect.
Home Products Applications About Us Knowledge Support Blogs Contact Hot sale


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Please turn your phone to portrait mode
The ODU Group is a worldwide leader in designing and manufacturing high-performance connector solutions and cable assemblies, ensuring reliable transmission of power, signals, data and media for applications from medical, military and security, eMobility, energy, industrial electronics as well as test and measurement. ODU has expertise across design and development, machine tooling and special machine construction, injection, stamping, turning, surface technology, assembly and cable assembly. It sells its products globally through subsidiaries in Denmark, UK, Germany, France, Italy, Sweden, the U.S., China and Japan, as well as international sales partners. In addition to its headquarters in Mühldorf am Inn, Germany, ODU also has production and distribution sites in Sibiu, Romania; Camarillo, California, U.S.; Shanghai, China; and Tijuana, Mexico.
From medical technology to consumer electronics to automotive technology: the trend towards miniaturization continues.
ODU offers highly reliable connection technology. The ODU Push-Pull circular connectors secure themselves and offer high performance and high durability.
High pin density / space saving connectors with various media transmissions, and break-away function for quick release.
Highly reliable circular connector solutions with Push-Pull locking, power - signal - data or media transfer, robust housing for a wide variety of medical, industrial, military and test and measurement applications.


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InVivo acquires Bioline
29 February 2016
InVivo has signed an agreement to acquire, through its holding company InVivo AgroSciences, Bioline, a subsidiary of Syngenta specialized in the production and marke-ting of biological control agents, and in particular macro-organisms active against insects pests in fruits, vegetable and flower crops.
By joining forces, Bioline and Biotop, a long-standing InVivo subsidiary working in biological pest control, will become a truly global player in a high-potential and fast-growing market. Investing in high-potential businesses to create French champions with critical mass is one of the clearly stated ambitions in the "2025 by InVivo" strategic plan. On the same level as digital agriculture, biosolutions* are among the main future paths that the InVivo group intends to explore as part of its drive to produce more and better.
Strengthened by its long-standing know-how with its subsidiary Biotop, the acquisition of Bioline will enable InVivo to build the capacities required to develop a significant activity in biosolutions. The growth of this USD 2.8 billion market is estimated at 10% a year for the coming ten years.
Bioline is highly present in the macro-organisms market and more specifically in mites in northern Europe used against predatory insects in greenhouse crops. Biotop has a bioplant in the Drôme department in France, specialised notably in the production of ephestia eggs (used for raising auxiliaries) and trichogramma (micro-wasps that fight against corn borers).
The two companies make a highly complementary fit through their expertise in arable crops and specialised crops, their geographical presence in France and internationally, and their portfolio of macro-organisms.
* Biosolutions = Biocontrol** + Biostimulants***
** Biocontrol = A plant-protection method using natural mechanisms such as insects, mites, bacteria, fungi, algae and plants.
*** Biostimulants = Substances acting on soil life and plant physiology so as to improve the crop strength, yield and quality.


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Carwyns Surfhouse
The Place
Shared & Private room options
Solo travellers
5 out of 5
The house itself was bought by ex to professional Welsh surf Carwyn Williams 16 years ago. Over the years the house has evolved from a training camp for some of todays current surfing champions, to being one of the longest running surf hostels in Europe.
Everyday we take you to the best surf spots for the current conditions and your surfing ability. We surf with you and offer any guidance necessary to ensure you are catching the most waves possible, and having the most fun in the water. We have a range of different boards all available for hire.
The house is very spacious and can sleep up to 16 people, with 5 bedrooms and 2.5 bathrooms. Outside there is a large entertaining area with a sun deck surrounding our swimming pool. This is the perfect place for a cold apré surf beer, from our very own pool bar (probably the best bar in town). We have an outdoor kitchen/ BBQ area where we prepare most of the evenings delicious meals. There's also a separate garden area with hammocks and a fire pit for relaxing and unwinding.
NOTE: Nightly price includes..
to buffet style breakfast
to surf guiding daily
to Transport to and from the surf house to surf spots
to Use of our bikes, skateboards and longboards,
to Free WIFI
The surfhouse is located in the beautiful pine to forests of Seignosse, just outside the famous surfing town of Hossegor. A short stroll through the forest is the small village Saubion, home to the best bakery in the area.
All the main beach breaks in Seignosse are less than 10 minutes drive away, and the town of Hossegor is 10 minutes drive away. The Spanish city of San Sebastian is less than an hours drive away, and is home to some of the finest foods and wines in the world.
- Reviews
- Facilities
- Room types
- Getting there
- Surf Lessons
- Waves
- Terms
October 2019
Travelled solo
How did you like the accommodation?
The Southwest Surfhouse us an absolutely wonderful place for everyone who loves surfing or wants to learn it. The accommodation has a really cool vibe but still feels a bit like being home due to the amazing people working there who made me feel very welcome. I stayed there for a week and enjoyed every minute at the Surfhouse, the beautiful beaches of Seignosse and Hossegor the great parties in town every night. I can definitely recommend this place to everyone who wants to have a laid back time with amazing people!
How were the surf lessons?
I took surf lessons with the house instructor Chris and that absolutely made my stay! He did a great job telling us the important things about the different beaches and currents and watched or assisted us when surfing. I felt safe the whole time, which made my first surf holiday a really fun time! Thank you Chris for never getting tired of motivating us!
September 2019
How did you like the accommodation?
Accommodation was as I expected.
I met very friendly people in this house and around in Hossegor. Aquitaine is a magic region.
September 2019
Travelled with friends
How did you like the accommodation?
When you stay at Carwyn's, you aren't just sleeping in a hostel, you are embarking on a journey, a journey of body, soul and some other stuff to. I don't want to spoil the fun, but expect to party lots and to generally do things you might not have expected of yourself. I can't recommend the place more highly
August 2019
Travelled solo
How did you like the accommodation?
Carwyn is an amazing host dedicated to making your stay the best possible. Delicious food, great vibes beautiful beaches. This place can't be beat!
How were the surf lessons?
Instructor took me into an intermediate group and provided valuable feedback. Also translated the lesson for me which was very much appreciated.
August 2019
Travelled with friends
How did you like the accommodation?
I never write reviews as I couldn't be bothered, but this place and the time I had ( 7 days July - Aug 2015) deserves it's first long review. Where do I even begin...words won't give this place enough justice. I travelled solo and didn't know what to expect, but I can tell you, I had the experience of a lifetime at Surf Hostel France ( also known as Carwyn's Surf Hostel) owned by the legendary Carwyn Williams ex-pro surfer and run by 2 Aussies, Ben and James. I'm South African, so having 2 Aussies around was great.
Everyday begins with an excellent free hot breakfast made by Ben or James. We check the surf report and drive ( no charge) to the best spot every day. The guests decide how long they wanna surf for, before heading back to the house for lunch/dinner or having lunch/dinner in town. The BBQ's they cook up for the guests in the evenings are fantastic !!! We were almost 16 people and they go out of their way to meet everyone's needs. I don't eat red meat or chicken and my needs got catered for everytime. Just brilliant!!
I timed this trip perfectly, as the 5 day Festival at Bayonne ( 30 km away) was on. They drove us to Bayonne every night! Believe me, Carwyn and the boyz know how to party!!! You'll see what I mean once you get there. Had the time of my life hanging out with these guys! And so did the other guests. Managed to make some good friends at this house.
Yes, the house is not exactly on the beach, but should you choose to stay at a place right on the beach instead, you better make sure they can drive you to the best breaks around the area, if not, it means you're most likely to only surf the same spot if you don't have a car, and that sucks big time, especially if the waves don't meet your criteria as per your skill level. Game changer for me!
Besides the surfing, the house is huge and decor is fantastic! Cool bar, proper working fast wi-fi, swimming pool, great healthy food ( I'm a fussy eater) , lounge area to chill and watch a movie...Exactly what I wanted from a chilled out surf house.
So for an excellent surf, plus a huge collection of boards, wetsuits, skateboards, bikes and awesome hosts who go out of their way to meet everyone's needs, you really don't have to bother to check out the other places, as I'm confident this can't be beaten. I met other guests who has stayed at other places in the Hossegor/Seignosse area, and they all confirmed my opinion!
Honestly, really can't wait to go back 2016 !
July 2019
Travelled solo
How did you like the accommodation?
I came to Carwyns surfhostel by myself and did not regret it once.The atmosphere is magic. People from all over the world meeting, talking, surfing together and in the end drinking a beer at the iconic bar. I really liked my stay (10 days) and can still feel the warmth of sunshine and friendship glowing.
If you want to go surfing around Hossegor, this is the place to be.
June 2019
Travelled solo
How did you like the accommodation?
Absolutely the best experience I could hope for! Radical house, incredible hosts, really fun surf, everything you need and just a wonderful place to hang out get to know people and be yourself. You're lucky to find a place like this. And Carwyn is the coolest dude ever.
June 2019
Travelled with friends
How did you like the accommodation?
Carwyn & the boys make this surf hostel a home away from home, they are welcoming & the house is beautifully re-decorated. They transport you to and from the beach, provide boards & wetsuits, and lessons if required - or just let you do your own thing, and pool in the garden is a perfect place to chill if the waves aren't that good. I went to many different surf beaches whilst staying here, and taken on some great nights out in Hossegor and around. They cook delicious meals, I had many fun nights drinking at the bar & made some amazing friends. Would highly recommend this to anyone wanting to go to the Hossegor/Biarritz area.
April 2019
Travelled solo
How did you like the accommodation?
The accommodation was amazing! Carwyn and Jane are lovely and they do everything they can to make it an unforgettable time. Carwyn drove me down to the beach everyday and gave me useful tips.
April 2019
Travelled solo
How did you like the accommodation?
The accommodation was amazing! Carwyn and Jane are lovely and they do everything they can to make it an unforgettable time. Carwyn drove me down to the beach everyday and gave me useful tips.
April 2019
Travelled solo
How did you like the accommodation?
Very welcoming and exceeded expectations. Carwyn and Jane were great hosts and made my stay even more enjoyable.
Additional Fees:Surfboards 10 euro per day
Room Type: Shared - Female
Sleeps: 4
The girls dorm sleeps 6 and features hand made driftwood bunk beds. Each bed has its own power point, with USB and reading light. The dorm also has its own private balcony (with hammocks) that catches the morning sun.
NOTE: Nightly price includes buffet style breakfast Surf guiding daily. Transport to and from the surf house to surf spots Use of our bikes, skateboards and longboards, Free WIFI
Room Type: Shared - Male
Sleeps: 8
The boys dorm is the only room downstairs and can sleep 6 to 8. It has its own en to suite bathroom and large living area.
NOTE: Nightly price includes buffet style breakfast Surf guiding daily. Transport to and from the surf house to surf spots Use of our bikes, skateboards and longboards, Free WIFI
Room Type: Private
Sleeps: 2
Upstairs the 'honeymoon suite' features his and her vanity sinks and a large jacuzzi style bath in the room.
NOTE: Nightly price includes buffet style breakfast Surf guiding daily. Transport to and from the surf house to surf spots Use of our bikes, skateboards and longboards, Free WIFI
Room Type: Private
Sleeps: 2
Finally there is one more private double room upstairs that overlooks the pool.
NOTE: Nightly price includes buffet style breakfast Surf guiding daily. Transport to and from the surf house to surf spots Use of our bikes, skateboards and longboards, Free WIFI
You can never get lost
When you book you will receive our confirmation email with full travel directions of how to get to us.
We don't provide airport transfers but you can book one easily here: Airport Transfers
- - Nearest Airport: Biarritz
- - Distance from Airport in kms: 44
- - Time from Airport in a car: 30 minute
- - There is no train from the airport
- - There is a bus from the airport
Come Surf With Us
Surf Lessons can be added in the booking steps if they are not already included in a package.
Main Surf Beach: Hossegor and surrounding beaches
Surf Lessons we offer:
Surf Guide
Surf conditions in Hossegor & Capbreton :
Air Temp (°C)
The beaches along the Hossegor and Capbreton coast stretch continuously north and south offering a huge choice of surf for everyone. Capbreton has 7 km of beaches starting at the busy side of town and extending south where sand dunes and pine forest merge gently with the incredible beauty of the vast expanse of the Atlantic Ocean. The beaches by the main town are perfect for beginners and intermediate surfing standards
Across the harbour is the famous surf town of Hossegor, where European surfing really took off. The main stretch of beach, Plage Centrale and La Sud, beside the main promenade are great place to learn to surf in Hossegor. For those more experienced there's the opportunity to surf the breaks where the Worlds No.1 surfers duke it out every September in the World Championship Tour, the legendary La Nord and La Graviere.
The beaches reach Seignosse a few km's north – here Les Bourdaines is perfect for longboarders, and Le Penon is a real quality beach break that's a bit quieter and just as much fun. Further south is Biarritz with its classic waves and stunning cliffs. And down by St.Jean de Luz is Belharra, one of the worlds most impressive big wave surf spots.
Come Surf Hossegor & Capbreton with us
- A small deposit is required to secure your booking.
- Your balance is due at check in.
- To cancel go to the MyAccount section and log in or register and you can cancel from within your account.
- Your deposit is non refundable but can be used for the same property/surf school within one year of your original booking.
- You can cancels anytime up to 7 days before travelling and you will not be charged the balance.
Similar Surf Packages in Hossegor & Capbreton , France
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- Host: Carwyn


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"It's really devastating that we're here again."
The crowd, which contained politicians, activists, faith leaders and citizens from across Rhode Island, listened Friday evening as …
"It's really devastating that we're here again."
The crowd, which contained politicians, activists, faith leaders and citizens from across Rhode Island, listened Friday evening as Katherine Kerwin introduced the Vigil for Change, an event hosted by the Rhode Island Coalition Against Gun Violence (RICAGV) in the wake of several mass shootings across the country.
As the sun set in a golden sky, the sprawling park at Dexter Field in Providence may have seemed an idyllic place for some late-summer unwinding – but the many local coalitions and political action groups present at the event weren't interested in relaxation. RICAGV was joined by the Rhode Island Latino Action PAC, the One Gun Gone Project, Moms Demand Action, and the Institute of Nonviolence to honor those fallen to gun violence, to discuss moving forward after recent tragedies, and to demand that those moved by the issue contact their local political leaders to incite legislative change.
On Aug. 3, a gunman took the lives of 22 people while opening fire with a semi-automatic rifle in a Walmart store in El Paso, Texas. Just a day later, another shooter took the lives of 10 people, including himself, when opening fire at a bar in Dayton, Ohio, with the use of a high-capacity, semi-automatic weapon technically classified as a pistol under federal law. A recent outbreak of shooting deaths in Chicago, Illinois, in the past week also became a major point of concern. These events, which once again shone a spotlight on the ongoing issue of gun legislation in America, were the primary subjects of remembrance during the vigil.
The event began with a group reading of "If It Were Up to Me," an anti-violence poem written by Cheryl Wheeler, led by members of the RI Feminist Chorus. Kerwin, Director of Communications for RICAGV and Councilwoman for Providence Ward 12, came to the podium to speak about the importance of political action in the face of tragedy, and to introduce Senator Jack Reed, who delivered a statement about his hopes for furthering gun legislation in order to bring about justice for the victims lost in the El Paso and Dayton shootings.
"At this point, I think I'm running out of words," said Nirva LaFortune, a Councilwoman of Ward 3 in Providence, who spoke of the emotional fatigue of having to endure repeated tragedies due to gun violence. "I am sick and tired of mourning these senseless deaths."
"We need to take action. We cannot make any more excuses. We shouldn't use violence to oppress people," she said.
The gunman who took 22 lives in El Paso had a violent anti-immigrant manifesto traced back to him by police, who believe he published the document online minutes before opening fire. The need for acceptance and to unite communities was a common theme throughout the vigil – many speakers were members of coalitions dedicated to minority rights, or individuals who spoke of the need for people to invite those who do not look like them into their homes and lives.
Rodrigo Pimental, a leader of Young Democrats of RI, is a recipient under the Deferred Action for Childhood Arrivals (DACA) policy who arrived in the United States at the age of 10 months.
"I am undocumented and unafraid," he said. "Words matter…that is why we cannot remain silent. We cannot consent to the status quo."
The so-called "Dreamer" program allows undocumented immigrants who arrived to the U.S. before the age of 16 the temporary right to work and live in America. Pimental hopes to attend URI to study data science under the DACA program, which the current presidential administration is seeking to eliminate.
Marcella Betancur, Vice President of the RI Latino Action PAC, spoke of the strength of communities even in the wake of tragedy, and how it inspired her to continue fighting for equality and justice despite when her observation that the deaths of people of color largely tend to go unacknowledged by the mainstream media.
Anna Saal, a rising freshman at Barrington High School, spoke out against the normalization of violence for many American teenagers due to constant news exposure, and the fear that has become an ordinary part of life for schoolchildren across the country.
Rhode Island Congressional Rep. David Cicillin, spoke of the need for increased gun regulation even in the face of political opposition.
Wendy Manchester Ibrahim, a Muslim and an activist for religious freedom, reached out to the community to offer support.
"I have spoken to you and tried to put your grief in words, and like you, I am very, very tired," Ibrahim said. "We have been asked to solve problems we cannot solve alone."
"If this resonates with you, I hope you want to be part of this conversation with me. Diversity is our strength," she said.
Her daughter, Halima Ibrahim, who was also present at the vigil, is one of the founding members of Rhode Island's March for Our Lives chapter. The March for Our Lives organization was originally founded by survivors of the shooting in Florida at Marjory Stoneman Douglas High School in 2017. Wendy grew up in Warwick and graduated from Pilgrim High School in the 1980s. She hopes that religion will be recognized as a valuable asset to unite communities, because of its inherently diverse nature.
The final speaker, Rev. Jamie Washam, closed the vigil with parting words as remembrance candles were being distributed and lit. A pastor of First Baptist Church in America, located in Providence, Rev. Washam told listeners to extend their friendship to members of the community that don't look like them; to invite new people to dinner tables and into homes to create stronger communities. She held her candle high and asked that no one be afraid to ask others for light when their fire ran out.
A moment of silence for the fallen victims of gun violence ended the vigil. The candles, which guttered in the late breeze, were soon lit again by others standing nearby.
Sounds like a whole lot of aggrieved women + Jack Reed lighting candles, reading poems, and singing songs. I'm sure it will have a profound impact the next time some thug pulls a gun in Providence, the most dangerous place in the state according to the FBI and where the event was held, and says: "...but they held their candles high..." And something tells me that Wendy Manchester Ibrahim's "activism" for religious freedom would not extend to Christian bakers. But that's just a hunch based on the affiliations of other gals in attendance. I'm sure they mean well, but it reads like a confluence of grievances.
I'm 1776% sure that no one is taking my guns.
Rodrigo Pimental, a leader of Young Democrats of RI" I am undocumented and unafraid,"
to attend URI to study data science under the DACA program, which the current presidential
i'm sure it will be for FREE on my tax bill!!! But can't help our homeless veterans!!!!
People say there won't be any trouble if they ban the guns. I say if you think there's mass shootings now? Wait till you try to ban the guns!
the last mass shooters were liberal antifa types who hated guns. Conor Betts had a extreme leftist twitter feed and was a member of Antifa and the El Paso shooter is accused of being Antifa, But Antifa is Blaming it on him being a Trumper. Course I sure wouldn't trust antifa as far as I could throw them.
The Second Amendment is and has always been about limiting the GOVERNMENT, not the citizens. Any infringement on that right by well-guarded politicians is unconstitutional.