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Author Affiliations
- Ignacio Criado1,
- Arancha Rodríguez-Caballero1,
- M. Laura Gutiérrez1,
- Carlos E. Pedreira2,
- Miguel Alcoceba3,
- Wendy Nieto1,
- Cristina Teodosio1,
- Paloma Bárcena1,
- Alfonso Romero4,
- Paulino Fernández-Navarro5,
- Marcos González3,
- Julia Almeida1,*,
- Alberto Orfao1,*⇑,
- The Primary Health Care Group of Salamanca for the Study of MBL
- 1Cancer Research Centre (IBMCC, USAL-CSIC), Department of Medicine and Cytometry Service (NUCLEUS), University of Salamanca, IBSAL and CIBERONC, Spain
- 2Systems and Computing Department (PESC), COPPE, Federal University of Rio de Janeiro (UFRJ), Brazil
- 3Hematology Service, University Hospital of Salamanca, IBMCC, IBSAL, CIBERONC and Department of Nursery and Physiotherapy, University of Salamanca, Spain
- 4Centro de Atención Primaria de Salud Miguel Armijo, Salamanca, Sanidad de Castilla y León (SACYL), Spain
- 5Centro de Atención Primaria de Salud de Ledesma, Salamanca, Sanidad de Castilla y León (SACYL), Spain
- Correspondence:
Low-count monoclonal B-cell lymphocytosis is defined by the presence of very low numbers of circulating clonal B cells, usually phenotypically similar to chronic lymphocytic leukemia cells, whose biological and clinical significance remains elusive. Herein, we re-evaluated 65/91 low-count monoclonal B-cell lymphocytosis cases (54 chronic lymphocytic leukemia-like and 11 non-chronic lymphocytic leukemia-like) followed-up for a median of seven years, using high-sensitivity flow cytometry and interphase fluorescence in situ hybridization. Overall, the clone size significantly increased in 69% of low-count monoclonal B-cell lymphocytosis cases, but only one subject progressed to high-count monoclonal B-cell lymphocytosis. In parallel, the frequency of cytogenetic alterations increased over time (32% vs. 61% of cases, respectively). The absolute number of the major T-cell and natural killer cell populations also increased, but only among chronic lymphocytic leukemia-like cases with increased clone size vs. age- and sex-matched controls. Although progression to chronic lymphocytic leukemia was not observed, the overall survival of low-count monoclonal B-cell lymphocytosis individuals was significantly reduced vs. non-monoclonal B-cell lymphocytosis controls (P=0.03) plus the general population from the same region (P≤0.001), particularly among females (P=0.01); infection and cancer were the main causes of death in low-count monoclonal B-cell lymphocytosis. In summary, despite the fact that mid-term progression from low-count monoclonal B-cell lymphocytosis to high-count monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia appears to be unlikely, these clones persist at increased numbers, usually carrying more genetic alterations, and might thus be a marker of an impaired immune system indirectly associated with a poorer outcome, particularly among females.
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the Western world, typically affecting older patients, particularly males, with a median age at diagnosis of 70 years (y) old.1 It is characterized by the accumulation of mature B cells in peripheral blood (PB), bone marrow (BM) and also secondary lymphoid tissues, with a uniquely aberrant CD19+ CD20+lo CD5+/++ CD23+ sIgM−/+lo phenotype and restricted immunoglobulin (Ig) light chain usage.2,3 Typically, CLL shows a heterogeneous clinical outcome; thus, whereas in some patients the disease remains stable and they will never require treatment, in around 70% of cases treatment is required and results in variable outcomes, from complete response and prolonged survival to refractory disease and death.3–5
Currently, it is well established that virtually every CLL case is preceded by monoclonal B-cell lymphocytosis (MBL) defined by smaller numbers of circulating PB clonal CLL-like B-cells (<5,000 clonal B-cells/μL) in the absence of any clinical symptoms or signs of disease.6 In 2010, MBL was further subdivided into low-count (MBLlo) and high-count MBL (MBLhi), depending on the number of PB clonal B cells (lower vs. higher than 0.5×109/L, respectively).7 While MBLhi has been reported to progress to overt CLL requiring treatment at a rate of 1–2% cases per year,8,9 no information is available at present regarding the ≥5-year risk of progression of MBLlo to MBLhi and CLL.10
The detection of MBLlo has become routinely feasible due to the use of highly sensitive flow cytometry (FCM) approaches for the screening of subjects from the general population who present normal blood cell counts. Of note, the prevalence of MBLlo is significantly higher than that of MBLhi and CLL, with a frequency that ranges between 3% and 14% of the general adult (≥40y) population, depending on the sensitivity of the FCM technique used.11 Independently of the method, it is well-established that the incidence of MBLlo progressively increases with age, with a prevalence >20% among individuals of more than 70 years of age.12 Whether MBLlo represents the normal counterpart of CLL (e.g., some studies suggest that MBLlo clones are more likely related to immunosenescence)13 or a very early stage of development of CLL, remains an open question. This is partially because, in contrast to MBLhi, long-term follow-up studies in large series of MBLlo cases have not been reported thus far, which limits our understanding of the biological and clinical significance of very low numbers of circulating CLL-like clones, as well as those factors and mechanisms involved in potential long-term progression of (conceivably) a minor proportion of all MBLlo cases to MBLhi and CLL; likewise, little information is available about the evolution of non CLL-like MBL. Such information is critical to a better understanding of the ontogenesis of CLL from the very early stages of the disease, and to better identify MBL patients with stable vs. progressive B-cell lymphocytosis who might benefit from a closer clinical follow-up.
Herein, we report on a cohort of 91 MBLlo (CLL-like and non CLL-like) subjects identified in a population-based screening study and followed for a minimum of five years (median >seven years). Our primary goal was to determine the rate of medium-term progression of MBLlo to MBLhi and CLL, and to identify the most relevant clinical and biological characteristics of PB lymphocytes associated with progression.
Subjects and samples
The baseline study was conducted from December 2007 to October 2009, when PB samples from 639 healthy adult (≥40y) volunteers (54% females/46% males) from the general population of the same geographical area (Salamanca, Northwest of Spain) were screened for the presence of small B-cell clones, using highly sensitive FCM.12,14 At inclusion, all subjects had normal PB cell counts and did not suffer from any hematological/immunological disease, as described elsewhere.1,6 In 91/639 subjects studied (14.2%), ≥1 PB clonal B-cell population was detected at recruitment; in the vast majority of them (80/91; 88%) clonal B cells were consistent with CLL-like MBLlo (<0.5×109clonal B cells/L showing a CLL-like phenotype), whereas the remaining 11 individuals (12%) were classified as non CLL-like MBLlo.12,14 MBLlo subjects were re-evaluated at a median time of seven years after recruitment (range: 61 to 95 months). All subjects gave their written informed consent at baseline for both the initial and the follow-up studies, and they filled out an epidemiological questionnaire with demographic and (self-reported) medical information, under the supervision of his/her primary care doctor.15 The study was approved by the Ethics Committee of the University Hospital of Salamanca (Spain).
Flow cytometry immunophenotypic studies
Overall, 1-4 mL of ethylenediamine tetraacetic acid (EDTA)-anticoagulated PB was collected per case and follow-up time-point; subsequently it was processed and analyzed using previously reported highly sensitive FCM approaches12,14,16,17 (Online Supplementary Methods and Online Supplementary Table S1).
Interphase fluorescence in situ hybridization (iFISH) studies studies
The most common CLL - i.e., del(13q14), trisomy 12, del(11q)(ATM) and del(17p)(TP53) - along with other B-cell chronic lymphoproliferative disorders (B-CLPD)-associated cytogenetic alterations were investigated by iFISH on fluorescence-activated cell sorting (FACS)-purified (sorted) single clonal B cells (≥95% purity), as previously described18 (Online Supplementary Table S2). A total of 31/91 PB samples studied at baseline and 56/65 at follow-up (year +7) were analyzed by iFISH; in 21 cases (18 CLL-like and three non CLL-like MBLlo) paired samples were analyzed by iFISH at both baseline and year +7. The potential presence of del(13q14) was also tested in non-clonal B-cells from 5/7 MBLlo cases found to have del(13q14)+ MBL cells.
Statistical analyses
All conventional statistical analyses (i.e., descriptive statistics, univariate analyses, including overall survival (OS) analysis, as well as multivariate analyses to predict the variables independently associated with a greater/lower risk of death), were performed with SPSS 19.0 software (SPSS-IBM, Armonk, NY, USA), using the tests, databases and statistical significance values detailed in Online Supplementary Methods. Appropriate tests were further used to objectively evaluate real changes in the size of the B-cell clones studied during follow-up (resampling bootstrap method)19 and to build a predictive linear regression model to estimate the time CLL-like MBLlo clones might potentially take to progress to MBLhi and CLL, using MATLAB R2015a (Mathworks, Natick, MA, USA) (Online Supplementary Methods).
Follow-up of the MBLlo cohort
From those 91 MBLlo individuals identified in the screening study performed in the general population of Salamanca between 2007 and 2009,12,14 65–71% of MBLlo cases from the original series; 29 males and 36 females; median age at baseline 70 (range: 43–84 years old)-; were re-evaluated after a median follow-up of seven years (range: 61 to 95 months) (Table 1). These 65 individuals were representative of the original MBLlo cohort for all variables analyzed, except for a significantly lower age (P=0.02) vs. those 26 individuals that could not be followed - median age of 75 (range: 48–95 years)-. These later subjects could only be re-evaluated for their death vs. alive status at the end of the study because of: i) 12/26 (46%) died before the fifth year of follow-up; ii) 2 subjects declined continuing their participation in the study; and iii) the remaining 12 cases were lost to follow-up after >5y from recruitment. Eight of 65 cases followed for >5y (12%) died afterward, making a total of 21 (26%) deaths among MBLlo cases included in OS analyses.
In all 65 individuals who were evaluated after five years, ≥1 clonal B-cell population was reliably identified in PB at follow-up. In 22/65 (34%) cases ≥2 clones were detected (vs. 32% at baseline), resulting in a total of 86 MBLlo clones detected (Table 1 and Table 2). All MBLlo clones showed an identical phenotype at both time-points (Table 2). Thus, 74/86 B-cell clones (86%) showed a classical CLL-like phenotype and 12 (14%) were classified as non CLL-like MBL clones. At year +7, 35/74 CLL-like clones (47%) corresponded to monoclonal cases and the remaining 39 (53%), to 19 subjects with bi(multi)clonal CLL-like MBLlo (Table 2); in two subjects, CLL-like and non CLL-like clones coexisted. Of note, two individuals carrying two CLL-like B-cell clones became "monoclonal" while a second clone emerged in one monoclonal CLL-like MBLlo case at seven years follow-up. In turn, non CLL-like clones (n=12) showed phenotypic profiles identical to those observed at baseline and comparable to those of different B-CLPD, as detailed in Online Supplementary Table S3.6
Clonal B-cell load in PB at re-evaluation (year +7)
Overall, a significant (P≤0.001) increase in the median size of MBLlo clones was found at follow-up, both for CLL-like (≈2-fold median increase) and for non CLL-like MBLlo clones (≈3-fold median increase) (Table 2 and Figure 1A,B). Such increased absolute number of clonal B-cells over time was associated with a significantly increased (P≤0.001) percentage of clonal B cells from all PB B cells (Table 2). In detail, most MBLlo clones (59/86; 69%) showed significantly increased numbers at re-evaluation vs. baseline, while the remaining 27 B-cell clones persisted at similar (16%) or lower levels (15%); this behavior was very similar for CLL-like and non CLL-like clones (Table 2). Of note, 30/35 (86%) CLL-like clones from (mono)clonal cases increased in size at follow-up vs. only 21/39 (54%) clones from bi(multi)clonal cases (P=0.004). Interestingly, among non CLL-like clones, most marginal zone lymphoma-like clones increased (5/6; 83%), while the two mantle cell lymphoma-like B-cell clones decreased significantly in number (Online Supplementary Table S3).
Cytogenetic alterations of MBLlo clonal B cells at baseline and follow-up
The overall frequency of CLL-like MBLlo cases carrying CLL-associated cytogenetic alterations, for example del(13q14), trisomy 12, del(11q)(ATM) and del(17p)(TP53), at baseline was of 29% (7/24 cases tested). At recruitment del(13q14)(D13S25) was found in 56%±34% cells from 6/20 cases evaluated (30%), the RB1 gene was additionally involved in 3 of them, and trisomy 12 was present in the remaining case (59% of cells), both as single alterations. After seven years of follow-up, the percentage of cytogenetic altered cases augmented to 62% of MBLlo cases (31/50 cases, including 15 cases studied at baseline). Interestingly, all cytogenetic alterations observed at baseline also remained at follow-up; in addition, 4/15 (27%) individuals studied at both time-points further acquired del(13q14)(D13S25) (Online Supplementary Table S4). Overall, del(13q14)(D13S25) remained the most frequent alteration at follow-up (27/48; 56%), affecting 32±27% of CLL-like cells. Of note, in five cases in which clonal B cells showed del(13q14)(D13S25), non-clonal B cells were also studied for this alteration, and was found to be absent in all of them. RB1 gene involvement was identified in only 1/7 cases tested; furthermore, trisomy 12 was restricted to one patient who had the same abnormality at baseline (Table 3). Clonal B cells from one individual in whom del(17p)(TP53) was not investigated at baseline was found to carry this cytogenetic alteration in 10% of cells at follow-up. Alterations involving 14q32 were investigated only at follow-up in a subset of 20 CLL-like MBLlo cases, being found in five (20%) patients (Table 3).
Regarding non CLL-like clones, t(11;14)(q13-q32) was detected in 100% of clonal B cells from one of the two MCL-like cases studied, while del(7q32) was detected in 2/5 splenic marginal zone lymphoma (SMZL)-like cases (Table 3). None of the cases investigated showed t(14;18) (data not shown).
Distribution of normal residual T-, B- and NK-cell populations
The PB counts of total T cells and their CD4+CD8−, CD8+CD4− and CD4−CD8−/lo subsets, as well as NK cells and normal residual polyclonal B cells was significantly increased (P<0.05) in CLL-like MBLlo at follow-up vs. baseline (Table 1). In contrast, among non CLL-like MBL cases, CD4+CD8+ T cells were the only lymphoid subset significantly increased (P=0.02) at the seven year follow-up. To rule out a potential age-related bias and further confirm these findings, we compared the number of PB normal lymphocyte subsets at seven years follow-up vs. a large series of non-MBL healthy donors matched per age and sex distribution to the CLL-like MBLlo cases at seven years (Online Supplementary Table S5) and the same differences were found, ruling out an impact of sex or more advanced age on the increased PB residual lymphocyte counts. No significant correlation (P>0.05) was revealed between the absolute number of clonal B cells and any of the normal residual PB lymphocyte subsets analyzed (data not shown).
Clinical and biological characteristics of CLL-like MBLlo at baseline vs. follow-up, according to the kinetics of the B-cell clone
Upon comparing CLL-like MBLlo cases with increased vs. stable/decreased clonal B-cell numbers at seven years follow-up, the former had a similar male/female distribution, but they were significantly younger (median age: 68y vs. 78y; Table 4).
Strikingly, MBLlo cases who showed larger CLL-like clone sizes over time also showed significantly higher (P<0.05) numbers of the distinct normal residual T-, B- and NK-cell subsets at follow-up (vs. baseline) (Table 4). Moreover, in these subjects a direct correlation was observed between the absolute number of clonal B cells and CD4+CD8− T cells (r2=0.5; P=0.001). In contrast, no significant (P>0.05) association was found between higher numbers of clonal CLL-like B cells in PB over time, and an increased frequency of cytogenetic alterations. Interestingly, del(13q14) was the sole genetic alteration detected at the seven year follow-up within cases with stable/decreased CLL-like B-cell clones, while those cases with increased CLL-like B-cell clones at year +7 showed cytogenetic alterations other than del(13q14), e.g., trisomy 12 (1/40), del(17p)(TP53) (1/39) and t(14q32) (5/20 cases tested) (Table 4).
Clinical outcome of MBLlo cases
Three subjects developed absolute lymphocytosis after seven years of follow-up (median: 5.3×109 lymphocytes/L; range: 4.1×109–5.9×109/L) in the absence of signs of disease. Two had CLL-like B-cell clones carrying del(13q14), while the remaining case had a non CLL-like clone. In one of the two CLL-like MBLlo cases, the size of the B-cell clone increased over the threshold for MBLhi (>500 clonal B cells/μL), while the other two cases remained as MBLlo. Remarkably, these three subjects displayed the highest increase in clone size at re-evaluation: this translated into a significantly lower (estimated) time to progression into CLL (median: 95y; range: 54–128y) according to the predictive mathematical model used. In turn, the estimated time to progression to CLL for the other MBLlo individuals was far beyond a normal life expectancy (median: 54,767y; range: 54–>63 million years).
Overall survival of MBL vs. non-MBL individuals
At the end of the study (January 2017), the clinical records and epidemiological questionnaires from all individuals recruited at baseline were reviewed. During follow-up, 21/89 (24%) MBLlo cases and 41/290 (14%) age- and sex-matched non-MBLlo subjects from the original cohort had died (P=0.03). Though the median OS for the two groups had not been reached yet, a significantly shorter OS was observed for MBLlo individuals vs. age- and sex-matched non-MBL controls from the same cohort and geographical area (10y OS rates of 76% vs. 86%, respectively; P=0.03) (Figure 2A,B). Moreover, MBLlo subjects also showed a significantly shortened survival vs. age-matched individuals of the general population from the same geographical region (8.0% vs. 1.8% in the period 2015-2016, respectively; P<0.001) (Online Supplementary Figure S1). Interestingly, such differences in OS were at the expense of a lower OS of CLL-like MBLlo females, who showed a significantly (P=0.01) higher risk of death (hazard ratio (HR) of 2.5; 95% confidence interval (CI) of 1.2-5.4) than non-MBL females of the same age (Figure 2C,F). Infections (21%; mostly respiratory infections and sepsis), cancer (36%; all solid tumors except for an essential thrombocythemia) and cardiovascular diseases (29%; i.e., myocardial infarction and acute ischemic stroke) were the main causes of death among MBLlo subjects. Overall, infections were overrepresented among the MBLlo cohort vs. age- and sex-matched subjects from the general population of the same geographical area (21% vs. 1.4%, respectively; P≤0.001). In contrast, the proportion of deaths caused by tumors (36% vs. 26%, respectively; P>0.05) and by cardiovascular diseases (29% vs. 33%, respectively; P>0.05) were similar in both groups. In turn, no MBLlo subjects died as a cause of non-infectious respiratory tract diseases or genitourinary diseases, diabetes, dementia or other nervous system disorders, which accounted for ≈30% of deaths in the age- and sex-matched general population cohort living in the same geographical area. In order to identify those variables independently associated with OS, a multivariate Cox regression analysis, including laboratory, epidemiological and medical information, was carried out. Advanced age- HR of 5.1; 95% CI: 1.5-17.5; P=0.01-, co-existing cardiovascular diseases (HR: 2.7; 95%CI: 1.3-5.4; P=0.01), solid tumors (HR: 2.9; 95%CI: 1.3-6.5; P=0.007) and, to a lesser extent, the presence of MBLlo clones (HR: 2.1, 95%CI: 0.97-4.7; P=0.06), were independently associated with a shorter OS in the whole cohort (Table 5 and Online Supplementary Table S6).
Several preceding studies have shown that virtually all CLL cases are preceded by MBLhi;8,20,21 in contrast, such a relationship has not been demonstrated for MBLlo cases, its role as a preleukemic condition still remaining to be confirmed.9,21 In fact, there exist very few studies with short-term follow-up (i.e., ≤3y) which have investigated the progression rate from MBLlo to MBLhi and CLL thus far.10,22,23 Hence, Fazi et al. showed persistent MBLlo clones over time in 90% of CLL-like MBLlo and only 67% of non CLL-like clones, after a median follow-up of ≈3y.10 Herein, we demonstrate the systematic persistence of both CLL-like and non CLL-like MBLlo B-cell clones with an identical phenotype to baseline after seven years follow-up in 65/65 MBLlo cases, confirming that MBLlo is not a transient condition. Similarly, Matos et al. also found the persistence of B-cell clones in their limited series of CLL-like MBLlo cases (n=5) after a median follow-up of ≈7y.23 Interestingly, in 3/56 CLL-like MBLlo cases, the number of clones identified at seven years follow-up changed, which might suggest the emergence of MBLlo from an oligoclonal background that mirrors competition and natural selection among multiple coexisting clones.24 Changes observed in the VDJ sequences of the expanded B cells from most of these cases (data not shown), together with the progressively decreasing rate of oligoclonality from MBLlo (12-19%) to MBLhi (2.9-13%) and CLL (0.7-3.4%), would further support this hypothesis.9,12,25–27 The significance of such oligoclonal B-cell expansions in MBLlo remains unknown, but might be the consequence of the early stages of altered oligoclonal immune responses against multiple antigens, in which a single clone had not yet emerged as dominant vs. the others, as might occur at the latter, e.g., CLL stage.
Most importantly, over two thirds of all CLL-like MBLlo clones showed a significantly increased size in PB after seven years, while for non CLL-like clones more variable kinetics were observed, depending on the specific phenotype of clonal B-cells. Interestingly, we also observed a significant increase in the frequency of cytogenetic alterations over time, evidencing that B-cell clones are not only dynamic in terms of clone size, but also regarding their capacity to acquire new cytogenetic alterations. Of note, del(13q14), which has been found to be a common mosaicism in the general population,28,29 was absent in non-clonal B cells from 5/5 cases investigated in which CLL-like clonal cells did carry this alteration, indicating that the emergence of this alteration in MBLlo is specific for the clonal population. Altogether, these findings suggest that cytogenetic alterations are a relatively early, but not primary, event in the natural history of MBL/CLL, and might have a potential role in the progression of MBLlo to MBLhi and CLL.
The presence and type of cytogenetic lesions, the IGHV mutational status, or the presence of stereotyped receptors are some of the most important prognostic factors in CLL, which also define the outcome of MBLhi individuals; furthermore, it might identify a subset of cases in whom the presence of the B-cell clonal population influences OS.30–33 Unfortunately, in the present study, the mutational status and VDJ rearrangements were only assessed (both baseline and follow-up) in 8/65 MBLlo individuals (data not shown), making it impossible to validate solid conclusions regarding the potential association with the risk for progression into MBLhi and CLL. To the best of our knowledge, the frequency and impact on disease progression of recurrent mutations (i.e., NOTCH1, SF3B1, MYD88, etc.) found in CLL, and also in MBLhi, to a lesser extent, has not been elucidated for MBLlo.34–36 Therefore, analysis of these CLL-related mutations in MBLlo cases might further contribute to an improvement in better delineating intrinsic tumor cell factors associated to disease progression.
In addition, the environment in which CLL-like MBLlo clones develop might be influenced by chronic immune responses against e.g., host viruses, that might play a critical role in the expansion of clonal B cells, as recently suggested.37 In line with this hypothesis, herein we also show that the expansion of CLL-like MBLlo clones after seven years of follow-up (vs. baseline) is accompanied by a significant increase of all T-cell (but CD4+CD8+cytotoxic T-cells) and NK-cell populations in PB.
Controversial results have been reported regarding PB T-cell numbers in MBLlo. Hence, while te Raa et al. found normal CD4+ and CD8+ T-cell counts in PB of MBLhi,38 other studies have demonstrated that around half of the MBLlo individuals show ≥1 clonal/oligoclonal CD4+CD8+ T-cell population, with an overall increased frequency of clonal T-cell populations vs. age-matched individuals from the general population.10,39 However, the presence of clonal (CD4+CD8+ and other) T-cell expansions has also been described as a common event in older individuals, and has been associated with the ageing of the immune system.39 In this respect, we demonstrate herein that changes in the number of circulating PB T-cell and NK-cell populations among our CLL-like MBLlo subjects were not age-related, via a parallel analysis of a large group of 250 age- and sex-matched non-MBL controls (Online Supplementary Table S5). From a pathophysiological point of view, the increase in most PB T- and NK-cell populations could be associated with either a potentially protective or activating effect of these cellular components of the immune system (microenvironment) on the expanded clonal B-cells.40,41 Therefore, on one hand, increased numbers of (functionally impaired) T cells have been described in CLL38,42,43 while on the other hand, we have recently shown increased titers of plasma antibodies against CMV and EBV in MBLhi and CLL patients vs. MBLlo and non-MBL controls, despite their antibody (immune)deficient state.37 Taken together, these latter findings might further support the existence of additional signals coming from immune cells other than clonal B cells, that could already contribute to the expansion of (cyto)genetically altered CLL-like clones at the earliest stages of disease, by promoting activation, proliferation and/or survival of specific B-cell clones.
A major goal of our study was to investigate the medium-term rate of progression of MBLlo to MBLhi and (potentially also) CLL. Overall, only one subject evolved from MBLlo to MBLhi, and none transformed to CLL, which would translate into a progression rate from MBLlo to MBLhi of 1.8% after seven years of follow-up. Despite the fact that the rate of progression of MBLlo to MBLhi and CLL appears to be extremely low, one of the most astonishing findings of our follow-up study was the significantly higher frequency of deaths among MBLlo subjects, associated with a significant adverse impact on OS vs. both non-MBL controls, particularly among females, and the general population (of similar age and sex distribution) living in the same region in Spain. However, comparisons with the general population must be considered with care, since the conditions of this population might differ from that of non-MBL individuals recruited at the Primary Health Services. Multivariate analysis showed a borderline significant association between the presence of MBLlo clones and a shorter survival. Despite this, the specific mechanisms responsible for the higher frequency of infections and deaths observed, particularly among women, are unknown, and further studies are required to validate and clarify these results. In this regard, controversial results have been reported on MBLhi subjects in the literature. Thus, while Shanafelt et al. showed no differences in OS of MBLhi vs. the general population,33 Shim et al. pointed out a higher frequency of deaths in their MBLlo cohort (4/11; 36%), albeit no statistically significant differences were found vs. non-MBL controls in the latter study, probably due to the small sample size.22 In addition, Fazi et al. also reported that 16/137 (12%) CLL-like MBLlo subjects died before re-evaluation after a median time of three years, which is a high proportion of their whole cohort.10 However, in the aforementioned report no information about the age of the deceased subjects is provided, and therefore, if it is the case they were older (than those subjects remaining alive) such high mortality rates might have been expected. Even more strikingly is the overrepresentation of infections as causes of death in MBLlo compared to that of our non-MBL cohort. Impaired immune responses and higher frequencies of infection have been recurrently reported in both MBLhi and CLL,44–47 but so far very little information exists in MBLlo, and such an association deserves further investigations. Several groups pointed out that the frequency of clonal hematopoiesis dramatically increases with age in the general population, especially among the elderly, in a similar way to the increased frequency of MBLlo, reflecting a clear relationship between clonal hematopoiesis and a higher risk of death.48,49 Whether or not both phenomena are related to MBLlo deserves future investigations.
In summary, we show herein that although MBLlo is a persistent and dynamic condition with a progressive acquisition of cytogenetic alterations, usually associated with an increased clone size and higher T- and NK-cell numbers in PB over time, progression of MBLlo to MBLhi and CLL is extremely rare in the medium-term. Despite this, the MBLlo subjects analyzed herein, particularly women, showed a shortened OS associated with an increased risk of death, particularly due to infections, further supporting the notion that MBLlo could be a marker of an impaired immune system, indirectly associated with a poorer outcome. Additional studies are necessary to confirm these findings and shed light onto the specific immune defects and microenvironmental factors involved in MBLlo.
The authors would like to thank "The Primary Health Care Group of Salamanca for the Study of MBL" for their contribution to the study; a complete list of members is included in the Online Supplementary Information.
↵* AO and JA contributed equally to this work.
Check the online version for the most updated information on this article, online supplements, and information on authorship & disclosures: www.haematologica.org/content/103/7/1198
This work was supported by the RD06/0020/0035 and RD12/0036/0048 grants from Red Temática de Investigación Cooperativa en Cáncer (RTICC), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, (Madrid, Spain and FONDOS FEDER); CB16/12/00400 grant (CIBERONC, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, (Madrid, Spain and FONDOS FEDER); the FIS PI06/0824-FEDER, PS09/02430-FEDER, PI12/00905-FEDER, DTS15/00119-FEDER, PI16/00787-FEDER and PI17/00399-FEDER grants, from the Fondo de Investigación Sanitaria of Instituto de Salud Carlos III; the GRS206/A/08 grant, (Ayuda al Grupo GR37 de Excelencia, SAN/1778/2009) from the Gerencia Regional de Salud (Consejería de Educación and Consejería de Sanidad of Castilla y León, Valladolid, Spain) and the SA079U14 grant (Consejería de Educación and Consejería de Sanidad of Castilla y León, Valladolid, Spain). ML Gutiérrez is supported by grant PTA2014-09963-I from the Instituto de Salud Carlos III.
- Received November 3, 2017.
- Accepted March 15, 2018.
- Copyright© 2018 Ferrata Storti Foundation
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So I am a total FAKE TAN ADDICT!!! There's no hiding it, I've the palest Irish skin you'll ever see. I'm practically see through.
Four weeks ago I was sent this stunning Bronze Tanning Box from Primark to test and try out their new tanning range. As you all know, I'm a HUGE fan of Penneys. For the last while if I'm looking for an instant tan I've been wearing the Medium Matte Sun Shimmer so I was delighted to see the Instant Tan Gel. The range is an affordable range that ticks all boxes when it comes to tan. So far I've tried out the exfoliator, the mousse and the instant tan gel, I've been really impressed. Before I continue, this isn't a paid blog post, I'm merely just telling you about the range and telling you what I thought of the products so far.
There is a step by step you can follow to get the perfect tan and is what the gals at Primark recommend:
- Pre Tan Exfoliator
- Pre Tan Primer
- Tan Mousse
- Instant Tan Gel
- Self Tan Eraser
So want to know more about the products?
Pre Tan Exfoliator €4.00
This gets your skin ready for your tan just like a facial exfoliator would do for your face cream. It contains walnut and pumice scrubs which help brighten your skin. I found it great and my skin was really super soft after. For €4 like it's so good.
Pre Tan Primer €4.00
I haven't tried this yet as it contains glycolic and I have to steer clear of this during pregnancy. This is super easy to use I can imagine as it's a spray bottle. It has glycolic peel which helps improve dull skin.
Tan Mousse €4.00
If you like a deep dark olive glow then this is the tan for you. It dries so so fast so no need to worrying about putting clothes on after as it will be dry. It's actually made in Ireland and doesn't have any harsh chemicals either so fine for all skin types. One thing I immediately loved was the really nice smell it had. It also has hyaluronic acid which is added to replenish moisture levels in your skin. It comes in three different colours, light to medium, medium to dark and extra dark. For €4 it's worth every cent.
Instant Tan Gel €3
For one of the Sun Shimmers, you can get nearly three bottles of this. Firstly it's matte so just gives you an instant colour that is dark and deep. I 'instantly' fell in love with this excuse the pun but it really was an instant love. It washes off immediately after and like the mousse smells so so good. It can be used on the face and body. It also comes in two colours light to medium and medium to dark.
Self Tan Eraser €4
This is a light foam formula literally will erase your tan immediately. One thing that's great is you don't need to scrub your skin really hard. I find that sometimes removing tan can be really difficult and this takes the hassle away. It has sodium bicarbonate and salt inside which tones down the shade of tan on your skin.
There are lots of other products in the range like:
- Back Tanning Mitt
- Coconut Tanning Balm
- Tan Water Mousse
- Tan Water
- Face Tanning Sheet Mask
I'd actually be dying to try out the sheet mask, back tanning mitt and tanning balm so I'll have to get in to get them before they all sell out.
I reckon this range will do so so well for Penneys in Ireland. It's affordable and actually a really good range so what more could you want?
Get to your nearest Penneys gals before it's gone.
Love Aoibhe xxx
Love Aoibhe xxx
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subset: commoncrawl


text:
Jun 11, 2019
I am using my new QC35 II. I thought it will be ideal to take calls apart from listening to music. It is good for music however not a perfect headphone for calls, as I keep getting the complaints for noise from my end. Even a light conversation near my end creates disturbance for the listener at other end. I tried maneuvering with noise cancellation button but it did not help much. If I put it in 'Noise cncellation off' I hear a echo of the noise myself ??
Can something be done for this?
Hello rahulmee,
Thanks for posting in the community, I am sorry that you are experiencing issues with your QuietComfort II headphones. I would be more than happy to help you today. I would recommend that you try a product reboot, please follow the steps below:
• Turn off the headset and wait 30 seconds
• Plug the headset into a wall outlet using a USB charger, then wait 5 seconds
• Unplug the USB cord from the headset and wait 1 minute
• Turn on the headset
I hope this helps, let me know how you get on!
Kindest regards,
Zoe C - Community Support
May 16, 2019
Apparently there is a firmware issue since 2.0.1, that they have not resolved. I had a pay and even did an RMA which had the same issue, the issue appears to be the fact the active noise canceling is actually picking up sound and sending it through to the Mic. I can also hear every sound any time the mic is turned on.
Hello rahulmee,
The reason there might be background noise is due to us tuning the communication microphones, mainly used for telephone conversations to the human voice frequency range. They automatically adjust the gain (microphone volume) for "low talkers". In a loud environment where there are voices in the background, it's possible the microphones will pick up those background voices and bring up the gain. This can send the background voices through to the far end person on a call. The person wearing the headset may hear this too (sidetone).
I hope this helps, should you need anything else then please get back in touch.
Kindest regards,
Zoe C


text:
Get ready for a mash up of great films and a great setting when the Heartland Film Festival Partners set up in the Historic Artcraft Theatre in Franklin, Indiana for "Best of the Fest," a two-day showcase of award winning films from the 2012 Heartland Film Festival.
The Artcraft Theatre first opened in 1922 and now operates as part of Franklin Heritage, Inc., which works to preserve the history of Franklin, Indiana. Classic movies are shown every week on Friday and Saturday.
The annual Heartland Film Festival is a 10-day event designed to highlight and honor uplifting, independent films. "Best of the Fest" is one of several community events that shares some of the films beyond the yearly October festival.
The movie line-up for "Best of the Fest," which will take place on Friday, April 19 and Saturday, April 20 includes:
Showtimes and film descriptions can be found on the Heartland Film Festival website. Tickets are $5 per film, $3 for Heartland Film Society or Historic Artcraft Theatre members.
Films marked with an asterisk (*) above include a post-show Q&A with the film's director and/or producer.
People who want to complement their independent film watching with an independent restaurant experience should consider these locations in Franklin for pre- or post-film dining.
No related posts.
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text:
"In case you haven't recognized the trend: it proceeds action, dissent, speech." ~ davidly, on how wars get done
"...What sort of meager, unerotic existence must a man live to find himself moved to such ecstatic heights by the mundane sniping of a congressional budget fight. The fate of human existence does not hang in the balance. The gods are not arrayed on either side. Poseiden, earth-shaker, has regrettably set his sights on the poor fishermen of northern Japan and not on Washington, D.C. where his ire might do some good--I can think of no better spot for a little wetland reclamation project, if you know what I mean. The fight is neither revolution nor apocalypse; it is hardly even a fight. A lot of apparatchiks are moving a lot of phony numbers with more zeros than a century of soccer scores around, weaving a brittle chrysalis around a gross worm that, some time hence, will emerge, untransformed, still a worm." ~ IOZ
Feb 2, 2011
dear good liberals
But, c'mon already.
He gives a clear signal to Mubarak that a crack down against the popular revolution is not US business...and a day later, Mubarak unleashes violent repressions.
Get it, yet?
13 comments:
- fwoan said...
Dude, whatever, you don't know what you're talking about. LILLY LEDBETTER!!!!!!!!!!!!!!!!!!!!!
::animated .gif of crying american eagle with WTC reflecting in his eyes::
- February 2, 2011 at 1:36 PM
- Jack Crow said...
Heh, fwoan.
I am so clearly wrong. Now the mostly white liberalistas who graduate from exclusive colleges can get paid as much their male counterparts in the bureaucracies and factor houses of empire.
In theory.
Obviously, Obama is a swell chap...
- February 2, 2011 at 1:44 PM
I dunno, Jack. Hillary Clinton was mighty persuasive in her vague assertions about American interests w/r/t Egypt... I'm pretty sure she gave Liberal America the confidence it needs to support BarryO.
Besides, Israel is urging everyone to support Mubarak, and we all know Israel is perfect, blameless and holy.
- February 2, 2011 at 2:10 PM
- Jack Crow said...
The New Liberal rag of record sure wants you to believe accordingly, Charles:
- February 2, 2011 at 2:40 PM
Hoo-ray for Hol-lywood!
Arianna's got more stars on her show than Bill Maher, Charlie Rose, Jon Stewart, Dave Letterman, Jay Leno. She wins!
- February 2, 2011 at 3:00 PM
...oops. I forgot Tavis Smiley, whose annoying presence and patois I discovered while watching TV during my Toobz hiatus. She beats him too.
Is that his real speaking voice -- inflections and cadence, they're natural? Or staged?
- February 2, 2011 at 3:02 PM
- Richard said...
Liberals will do what they always do. Stand behind their man when it matters, and then, 6 months from now, if Mubarak prevails, they will cry crocodile tears over the deaths and other brutalities inflicted upon the Egyptian people, expressing mystification as to why Obama hasn't done anything about it, or, even worse, rationalize it by observing, "well, you know, you can't expect him to go against Israel". Yes, you got that right, they will defend him by reference to a soft focus anti-semitism, if necessary.
- February 2, 2011 at 3:58 PM
- Tao Dao Man said...
New boss same as the old boss.
O's response is sickening.
But it was expected.
"Transition" is code speak for --we want to keep the status quo--.
The Zionistas in Israel and in the U.S. are preparing a response.
Well Mubarak and his thugs have responded.
- February 2, 2011 at 10:15 PM
- Randal Graves said...
I can't believe no one brought up the undeniable truth that you can have either a Democrat or a Republican Super Hiter so you best vote smrt!
- February 3, 2011 at 8:39 AM
- Sam said...
buh buh buh ... ZOMG! Michelle Bachmann! We must support our Preznit!
- February 4, 2011 at 8:50 AM
- Jack Crow said...
It's funny how they run through bogeymen/women, eh? Sarah Palin didn't prove particularly flappable, so one to Bachmann. And next?
- February 4, 2011 at 3:13 PM
- Sam said...
Especially ambitious women - their faults notwithstanding. One might reasonably suspect that liberals prefer a world without women - just the bros Jon Stewart, Lightbringer, Yggie, Ezra, Olbermann, etc. doin' whatever bros do w/ each other!
Although...ZOMG! Glenn Beck unilaterally gave us Romney/ObamaCare, no-bid merc contracts, and $22 trillion in (guaranteed) rents to the FIRE sector. Sign this MoveOn petition! Oh, and Jim DeMint is about to privatize SS/Medicare b/c of a "budget" "crisis." Dirty Christianist!
At SMBIVA, there's a chapter in the manuscript with the blog's namesake that distinguishes b/w leftism and liberalism. And i think we all know pwogwessive is merely a euphemism for liberal, if only with more status inflation.
- February 4, 2011 at 9:49 PM
- Jack Crow said...
We are in fundamental agreement. It's very telling that the way they (progressives/liberals) go after Palin and Bachmann is by attacking their intelligence, a not very subtle attempt to portray them first and foremost as stupid and presumptuous women.
- February 4, 2011 at 10:09 PM


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- ShadowTuga
- Chapa Zero in Portuguese translated to English would be Chapa Zero.
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Free Return on all orders. . shipments will be delayed.
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The Spring/Summer 2018 Men's Collection is dedicated to informal sportswear for men who are not willing to give up on quality and elegance, even during leisure time. Lightweight jackets, completely unlined, have been updated in the fit that becomes slimmer and refined with subtle details recalling a tailor-made craftsmanship. Fabrics are precious and range from the finest cashmere to linen-silk-cashmere. They are developed in different percentages of compositions and micro-designs that give three-dimensionality to the garment making it crease-resistant.


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Giant Joeys, Paintbrushes, Geo-Picks and Acid
19/09/2019 @ 5:30 pm - 7:00 pm
One thought and the tools of trade for an amzing journey of discovery. Dr peter Trusler, an internationally renowned science illustrator will talk about reconstructing Australia's cave-fossil megafauna. Including Palorchestes, a giant marsupial 'tapir' that Peter describes as "The weirdest marsupial to have ever lived. And that's saying something from an entire menagerie of Australian animals and birds with an international reputation for the weirdness"
Held at South West Regional Tafe, 272 Bussell Highway, Margaret River.
Plesae register your attendance on 0897572202 or email [email protected]


text:
The Bring Back Our Girls (BBOG) group has accused the Nigerian military of blocking and arresting over 60 parents of the 219 Chibok girls abducted by Boko Haram in 2014 from partaking in a planned protest scheduled for Thursday, January 14, 2016.
READ ALSO: #BringBackOurGirls Top Campaigner, Oby Ezekwesili May Quit Social Media In 2016
The Nigerian Army had on Tuesday, January 12, arrested about 60 parents of the Missing Chibok school girls, while they were on their way to Abuja for an Aso rock protest.
It was learnt that the women boarded seven buses from Maiduguri, the Borno State capital, but were stopped at two checkpoints (in Chibok and Askira), with only two of the buses allowed to proceed to Abuja.
Premium Times was later informed by the group that the military said that some of the buses were blocked due to security concerns concerning the gathering of "such a crowd in the face of the current security situations."
The group demanded a public apology, and a commitment from the military to produce the parents in Abuja for the proposed protest.


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Despite being Friday 13, that was a very strong day for us. With one small stop, trades just worked and worked. Aside of all the usual suspects (C, JPM, GDX, GLD, FB etc, you know) we also got two strong trades on ADBE and one on LULU. Just to make a menu less boring, you know. Very nice week overall, mostly thanks to the last two days.
Session Time: Fri Dec 13 00:00:00 2013
[08:48] {nemo} Where's Knuckles?
[08:49] {nemo} Here's a scary thought...I haven't watched financial TV in years...I had a dream where I was watching Cramer's show...wtf
01[08:51] {Threei} lol
01[08:51] {Threei} morning
[08:52] {barbo} GM
01[08:52] {Threei} barbo :)
[09:05] {cc_9} [yawn]
[09:05] {cc_9} GM all
[09:05] {nemo} Knuckles
01[09:05] {Threei} cc9 :)
[09:05] {nemo} apc and rh cc
[09:06] {cc_9} yup, u got it nemo, gm m8
01[09:07] {Threei} wow... Kim killed his uncle
[09:07] {cc_9} APC triple downgrade nemo
[09:08] {nemo} bfd...god what I would do if I could get away with it
01[09:08] {Threei} learned from the best I see... pages from Stalin's book
[09:08] {nemo} ahhh, yes, the seminarian
[09:09] {cc_9} North Korea is Best Korea, comrade
[09:12] {cc_9} SPY not much action overnight and on eco #s pre-market.
[09:14] {dino} gm
[09:15] {fish_49} huh Kim fired him now he killed him?
01[09:15] {Threei} dino :)
[09:15] {fish_49} his Sam Chun (Uncle) is who got him the position
01[09:15] {Threei} yup... internal power struggle obviously
01[09:16] {Threei} and very fine understanding of Stalin teachings
[09:16] {fish_49} CC is a Commie for sure
01[09:16] {Threei} liquidate everyone who helped you on your way up
[09:16] {dino} rule thru fear
01[09:16] {Threei} they know who you really are and how you evolved, they are a potential threat
01[09:17] {Threei} they know skeletons in your closet
[09:17] {fish_49} wonder how he took him out.. Who he had do it and method.. You think it was like the old Josun days of Sword across neck? lol
[09:17] {Will49} gm
[09:17] {dino} 8" of snow tonight
01[09:17] {Threei} will :)
01[09:17] {Threei} sorry dino...
[09:17] {fish_49} where Dino?
[09:17] {dino} northeast pennsylvania
[09:19] {fish_49} hmmm must be Scranton area Im 2 hours south of you I didn't know there was bad weather coming
[09:20] {dino} 40 miles ne scranton. storm starting around midnight, all day tomorrow
[09:21] {dino} where you at fish, allentown?
[09:22] {cc_9} the cc list for today : GILD - AFSI - RH - CIEN - GDX - DGAZ - XIV - APC
[09:22] {fish_49} no half way between Philly and Baltimore perhaps more like 3 hours south of u
[09:23] {fish_49} I wonder if Denis Rodman will be attending the funeral of his Uncle in law lol
[09:24] {fish_49} thanks Dino for the info I will get the snow blower ready
[09:24] {dino} apc, insy
[09:25] {fish_49} Targeting Crude Long set up CL at 96.10
[09:29] {cc_9} GILD nice gap up
01[09:31] {Threei} Short Setup: GDX .20 break
01[09:31] {Threei} If holds .30
[09:32] {cc_9} APC some bids
[09:33] {cc_9} nope, slammed back under 74 fast
[09:33] {cc_9} long APC here
[09:33] {cc_9} for 75+ tgt
01[09:35] {Threei} stop to .26
01[09:36] {Threei} 1:1
[09:36] {dino} insy sm l .01
[09:36] {dino} rh sm l .65
[09:36] {cc_9} APC lets go
[09:37] {cc_9} damn it i missed RH
[09:37] {cc_9} APC nice buys here, staying with it
[09:37] {dino} out rh .35, +.70
[09:37] {dino} too soon
[09:38] {cc_9} APC $75.00 tgt
[09:38] {cc_9} stiull going
[09:39] {cc_9} all out APC +$1.16
[09:39] {cc_9} booyah
[09:39] {robbers} nice.
[09:39] {Will49} great!
01[09:39] {Threei} Long Setup: C .05 break
01[09:39] {Threei} If holds 51
01[09:40] {Threei} aggressive for .10
01[09:40] {Threei} meh
01[09:40] {Threei} SPY suddenly died
[09:40] {cc_9} APC } $75.50 still going
[09:40] {cc_9} will revisit if retraces
[09:41] {nemo} 74.90 =23.6
[09:42] {cc_9} RH flying
[09:44] {dino} out insy .80, +.79
[09:44] {Will49} hit'n em dino
01[09:44] {Threei} Short Setup: JPM .23 break
[09:45] {dino} thx
01[09:45] {Threei} If holds .30
[09:45] {cc_9} APC setting up for another run up
[09:46] {cc_9} long APC here again
[09:46] {cc_9} for 76 tgt
[09:47] {cc_9} all out APC for another $0.63
[09:47] {cc_9} I freaking love this stock today
[09:47] {nemo} wait cc I didn't tell you to sell yet
[09:48] {cc_9} already at my goal for today
[09:48] {cc_9} Friday, gonna take it easy m8s
[09:49] {dino} same here cc
[09:50] {cc_9} wtg
[09:50] {cc_9} Best way to finish the week
[09:50] {cc_9} I am certain APC flies way higher, but this week has been radioactive green
[09:51] {dino} apc 76 wall/trig
01[09:52] {Threei} 1:1
[09:52] {nemo} wow look at that activiy apc
01[09:53] {Threei} just heard from ese
[09:53] {Will49} what jail?
[09:53] {fish_49} lol
01[09:53] {Threei} no need for a bail will
01[09:54] {Threei} which is a welcome relief
[09:54] {Will49} i'm ready
[09:54] {fish_49} out JPM thanks Vad
01[09:54] {Threei} yw
01[09:54] {Threei} crazy buzy with permormances, says hello to everyone and promises to be here as soon as he can
01[09:54] {Threei} 1:2
[09:55] {Will49} yes..he's buzy alright
[09:55] {dino} out apc .34, +.33
[09:56] {cc_9} RH killing it wow
[09:58] {cc_9} here
[09:58] {cc_9} comes
[09:58] {cc_9} the
[09:58] {cc_9} crash
[09:58] {cc_9} get ready folks
[09:58] {nemo} apc running too
[09:59] {Will49} bring it ON
[09:59] {dino} apc, rh, and insy, nice way to start the day
[10:00] {cc_9} APC is a darling today
[10:00] {cc_9} soon as it cracked $75.00 the downside was pretty much all put
[10:00] {cc_9} and only up from there
[10:01] {Will49} so much for the crash
[10:02] {nemo} 77.50ish next test area
01[10:04] {Threei} Long Setup: TZA .90 break
01[10:04] {Threei} If holds .85
[10:05] {cc_9} will, its all headfakes, if market wanted to rally, it would not be testing yesterday's LOD
[10:05] {cc_9} we shall see
[10:06] {cc_9} FB all out goat
[10:06] {cc_9} charging
[10:06] {dino} gimo drop
[10:06] {nemo} one would think it will stay in a range today, why scare people going into the weekenbd
01[10:06] {Threei} why not?
[10:07] {dino} will, crash? f' the talking heads. the tape is the truth
01[10:07] {Threei} scare them young
[10:08] {Will49} is cc our talking head?
[10:08] {cc_9} dino is my new gap plays buddy
[10:08] {cc_9} nice work on apc/rh/insy
01[10:08] {Threei} can I pich the talking heads for that purpose?
[10:08] {dino} thx & happy to help
01[10:08] {Threei} pick
[10:08] {cc_9} SCTY breaking out
[10:13] {cc_9} wowza P
[10:13] {nemo} yeah, number 1 strong on the algo
[10:13] {nemo} followed by x amzn bidu scty
[10:13] {cc_9} idk how in the crap i took it off my list
[10:13] {nemo} weak: slb lulu anf cam
[10:13] {cc_9} i traded P yesterday
01[10:14] {Threei} 1:1
01[10:15] {Threei} ok... it's official: my parcel with wines and cheeses has landed on the top of Mt. Olympus yesterday morning. Whatever I did to anger trading gods on Wed, all is forgiven
[10:15] {Will49} as cc says ..we shall see:)
01[10:16] {Threei} hey, nobody said they won't get angry every again {G}
01[10:16] {Threei} ever
[10:16] {Will49} indeed
[10:16] {Will49} live for the moment
01[10:17] {Threei} right... at the moment I am distracted by the process of selection of talking head dino suggested to do some naughty things to
01[10:17] {Threei} CNBC and bloomberg have some fine choices
[10:17] {fish_49} lol
[10:18] {Will49} they've cornered the market
[10:18] {fish_49} I suggest a CC talking head to keep you busy after markets close
[10:18] {fish_49} lol
01[10:18] {Threei} I'll pass, thanks
[10:18] {fish_49} lol
[10:18] {fish_49} lol
01[10:18] {Threei} 1:2
01[10:19] {Threei} btw, speaking of adjusting to the market... you did notice this pattern of late, SPY sudden drops?
01[10:19] {Threei} TZA trade was based on this
[10:19] {cc_9} you see now Will ?
[10:19] {cc_9} there is the tank :)
[10:19] {cc_9} VXX now going ;)
[10:19] {Will49} better late than...
[10:20] {Will49} broken clock is right twice...
[10:20] {Will49} etc etc
[10:20] {cc_9} w/e you say
[10:21] {cc_9} SPY needs to lose this 177.80 for a proper dog tank
[10:21] {fish_49} Speaking of Patterns I used your DB pattern in the book (PG 143) on a 5 min to get 25 ticks on the Crude Oil Contract
[10:22] {fish_49} perfect picture first drop outside BB's second drop just inside BB's
01[10:23] {Threei} :)
01[10:23] {Threei} amazing how these things work over and over
[10:23] {cc_9} and there you have it Will
[10:23] {fish_49} Trading is the hardest Easy money I have ever earned
[10:24] {Will49} ok, i give
01[10:24] {Threei} well... thing to remember is,
01[10:24] {Threei} market is the easiest place to make money,
01[10:24] {Threei} and the hardest place to keep it.
01[10:25] {Threei} Thus, risk control is paramount
01[10:25] {Threei} that's what allows you to keep what you make
[10:25] {fish_49} yes this is why I use hard stops lol
01[10:25] {Threei} anyone can make money when get the setup right
01[10:25] {Threei} what separates men from boys is how you act when you get it wrong
[10:25] {cc_9} GILD 15min looks tired
[10:26] {Will49} hey fish...the "hover" method is superior to hard stops
[10:26] {dino} profuts=luck; losses=skill
[10:26] {dino} profits too
01[10:26] {Threei} see full internet of people who can't take their stop for the world of them
[10:26] {Will49} goverment approach
01[10:26] {Threei} see them whine about their huge losses
01[10:26] {Threei} blaming damn manipulators
01[10:26] {Threei} fed
01[10:26] {Threei} government
01[10:27] {Threei} talking heads
01[10:27] {Threei} neighbor's dog
[10:27] {nemo} wow, weak side really filling out on algo
[10:27] {Will49} haha Vad
01[10:27] {Threei} meanwhile the only person to blame is themselves
01[10:27] {Threei} it was up to them to take small loss
[10:27] {fish_49} Will the hover method works well until you lose data connection
[10:27] {fish_49} lol
[10:27] {cc_9} SPY for now held yesterday's lows
[10:27] {cc_9} GDX new highs
[10:27] {Will49} true fish
01[10:27] {Threei} but no, they had to get all proud and strong and prove they were right
[10:28] {dino} twc spike
[10:29] {dino} missed it
[10:29] {cc_9} Charter to offer TWC under $140.00
[10:29] {cc_9} dumpathon
[10:30] {nemo} hey cc, how about some more of your off-color non-pc humor
[10:30] {fish_49} lol
[10:30] {fish_49} lol
[10:31] {fish_49} Vad if ur not busy look at CAT
[10:31] {fish_49} a pull back into around .67 then rally tto gap fill?
[10:31] {cc_9} I'm waiting for 2PMish, when Vad slips in his jammies and takes a nap
[10:31] {cc_9} then the jokes will come out
[10:31] {cc_9} i dont want to get banned on a Friday
01[10:32] {Threei} lol
[10:32] {nemo} why? he has all weekend to calm down and let you back in on Monday
01[10:32] {Threei} but fish... I am really busy NOT looking at CAT
[10:32] {nemo} the worst that could happen is if you go and visit he makes you stay with ese
[10:32] {fish_49} ok play with your CC talking head then
01[10:33] {Threei} .67, I doubt it'll go that low
01[10:33] {Threei} and if it does, we will need some new pattern
[10:33] {fish_49} .70
01[10:33] {Threei} as it stands, .85 break is long setup
[10:33] {cc_9} TWC back to lows
01[10:33] {Threei} not powerful enough to get me interested
01[10:34] {Threei} but it's a valid setup
[10:34] {fish_49} 15 minute setting up a C&H
01[10:34] {Threei} if loses .75, no read until something new shapes up
01[10:35] {Threei} (US) Reportedly FBI to hold press conference later today to discuss arrest involving a "national security matter" - twitter sources
[10:35] {fish_49} Found Snowden?
[10:35] {cc_9} Today I think I want to get a proper straight blade warm towel face shave by a professional
[10:35] {nemo} arrested Obummer
[10:36] {nemo} I'll do it for you CC...I'll use my CRKT
[10:36] {dino} we can only hope
[10:36] {dino} chtr spike
[10:36] {cc_9} its sad nowadays we dont have many of those places around
[10:36] {cc_9} nice shave
[10:37] {fish_49} I get one at least every other day when I'm in Korea or Japan
[10:37] {fish_49} Plenty of places
[10:37] {cc_9} "Korean or Japan", might as well say you also get one on Jupiter's Europa
[10:38] {cc_9} Cuz they are just as far
[10:38] {fish_49} not so far
[10:38] {fish_49} lol
[10:38] {fish_49} I will be there next week again
[10:38] {fish_49} gonna spend the holidays there
[10:38] {cc_9} Tell the truth
[10:38] {cc_9} why are you going there
[10:38] {fish_49} The happy ending massage?
[10:38] {cc_9} No, that's thailand
[10:38] {cc_9} Japan is for the vending machines that dispense used panties
[10:39] {cc_9} no lie, google it.
[10:39] {fish_49} hahahah yuck
[10:39] {nemo} yeah, everything on google is gospel
[10:39] {fish_49} do they come with expiration label?
[10:39] {cc_9} http://3.bp.blogspot.com/-_4-YllXaojc/T6I4SiPLg7I/AAAAAAAAy94/Gv9y6KUe7zY/s1600/Used_schoolgirl_panties_vending_machine.jpg
[10:39] {fish_49} a few years back I was in a Sushi bar there and they had O2 booths
[10:39] {Will49} sheeesh
[10:39] {dino} well if its on the internet it has to be true
[10:40] {fish_49} administer your own O2
[10:40] {nemo} yeah, dino, you can keep your doctor
[10:40] {cc_9} Who in their right minds would go on the internet to tell lies...of course its true
[10:40] {Will49} another "world going to hell..." example
[10:40] {nemo} aaahhhh
[10:40] {nemo} fellas
[10:40] {nemo} last Pope said that whole "Hell" thing they just made up
[10:40] {fish_49} now tell us CC what brought you to the point of Looking that up?
[10:40] {fish_49} lol
01[10:40] {Threei} No One ever lies on Internet. ~G. Washington
[10:41] {Will49} lol
[10:41] {fish_49} Gore made a rule when he invented the internet. NO LYING
[10:41] {cc_9} oh, the simple fact that you said you get shaves in Japan every other day
[10:41] {cc_9} and me implying thats not why you go there for
[10:41] {cc_9} you know, THE TRUTH
[10:41] {fish_49} lol
[10:41] {fish_49} too expensive there and when I travel there, the wife is always with me
[10:42] {cc_9} the wife as in the plastic Japanese doll that you dress ?
[10:42] {cc_9} bc thats big in Japan too
[10:42] {fish_49} Korean
[10:42] {fish_49} lol
[10:43] {fish_49} nothing is Big in Japan CC
[10:43] {cc_9} lol touche
[10:43] {cc_9} and the e is with an accent
[10:43] {cc_9} also, lets crash
[10:44] {Will49} better to ask isn't ti?
[10:44] {Will49} it
[10:46] {cc_9} it depends on how drunk she is
[10:47] {Will49} :)
[10:47] {cc_9} look at that beautiful rape face
[10:47] {cc_9} :) has to be the creepiest face
[10:47] {nemo} ?
[10:47] {Will49} ?
01[10:47] {Threei} janitor starts frowning
[10:47] {cc_9} ???
[10:48] {Will49} what you smokin?
[10:48] {fish_49} CC you woke Nemo and Will up
[10:48] {cc_9} lol fish
[10:48] {nemo} it's not 2
[10:48] {cc_9} SPY setting up for a dump imo
[10:48] {cc_9} its under its close, could not break yesterdays highs and still testing yesterday's lows
[10:49] {Will49} ahh...you smokin chrystal....ball
[10:49] {nemo} but do they want to really start a panic going into the weekend S1 at .65
[10:49] {cc_9} I think we will see a stampede this year, not a santa rally
[10:50] {cc_9} no buyers stepped in on Wednesday nor Thursday
[10:51] {fish_49} Holding out for Fed meeting
[10:51] {fish_49} makes me wonder if someone leaked any infor or is it pure speculation
[10:51] {RonS} open smacked
[10:52] {cc_9} APC setting up for another rally here to 78
[10:52] {fish_49} Lost S1
[10:53] {RonS} Apple Files for a Patent on a Restaurant Reservation and Ordering System
[10:53] {cc_9} DGAZ, look at this pathetic 15min chart
[10:53] {cc_9} DGAZ back to all time lows
[10:54] {cc_9} there goes APC
[10:54] {fish_49} Bounced off S1 lol 5 minute chart looks like inverted H&S on SPY
[10:55] {cc_9} FB "the goose is loose"
[10:56] {nemo} apc butting it's head on the 38.2 retrace
[10:57] {nemo} that's that .50ish level
[10:58] {cc_9} DGAZ getting gassed
[10:58] {cc_9} 8.10
[10:58] {cc_9} death imminent
[10:58] {nemo} hanging around with Ron too much
01[10:59] {Threei} I had different version... "not enough"
01[10:59] {Threei} Long Setup: TZA .15 break
[11:00] {dino} dgaz stinks
01[11:00] {Threei} of course... they add the stinking component
[11:01] {cc_9} "most Americans think Bitcoin is an iPhone app or a video game"
[11:01] {fish_49} It's not?
[11:01] {cc_9} why am I not even remotely surprised
[11:01] {fish_49} lol
[11:01] {cc_9} HON pop on share buyback
[11:04] {cc_9} SPY, there is the fear
[11:05] {nemo} apc going up in this drop
01[11:05] {Threei} 1:1
[11:06] {cc_9} IWM at lows
[11:06] {cc_9} SPY playing catchup
[11:06] {cc_9} crash already
[11:06] {fish_49} Out here Thanks vad
[11:06] {Will49} peace fish
[11:07] {Will49} oops thought you were leaving
[11:07] {fish_49} Peace to u too Will
[11:07] {fish_49} lol
[11:07] {cc_9} if any drop in FB, will get long
[11:07] {cc_9} very strong so far today
[11:07] {Will49} as our Quebecois say...peace on you Anglais
01[11:08] {Threei} and what they actually mean is "pees"
[11:08] {Will49} yup
[11:13] {cc_9} SPY just teasing...
[11:13] {cc_9} lol @ I still have an order to short HON at 87.45
[11:13] {cc_9} damn it...
[11:14] {fish_49} buy the pull back BTFD
[11:15] {cc_9} buyback and M&A chatter stocks, I only short the upside, which I intended to do on HON, only my limit was slightly higher
[11:16] {Will49} HON was my career company..recruited right out of school
[11:17] {fish_49} what field
[11:17] {nemo} engineering?
[11:17] {Will49} commercial HVAC
[11:17] {nemo} wow
[11:17] {Will49} yes...sales engineer
[11:17] {fish_49} better than their Sanitation Engineer
[11:17] {Will49} lol
[11:18] {cc_9} FB still going
[11:18] {RonS} tsla acting like it's going to rip
[11:18] {cc_9} SPY no dog crash :(
[11:19] {fish_49} Will Is JCI (Johnson Controls) doing the same HVAC stuff?
[11:19] {Will49} yes
[11:19] {Will49} they were main competition in those days
[11:20] {fish_49} I see plenty of HON hardware around but never any hardware for JCI
[11:20] {Will49} yeah, noticed that too
[11:21] {Will49} JCI may have sold off controls division
[11:21] {RonS} better than selling the johnson...
[11:21] {Will49} LOL
[11:22] {fish_49} lol
[11:24] {nemo} vad like lulu drop of .85?
[11:24] {cc_9} late, but lol
[11:24] {nemo} too late
[11:25] {cc_9} so sad...cant even get a proper crash :(
01[11:26] {Threei} looks right to me... maybe gives a chnace for entry
01[11:27] {Threei} there
01[11:27] {Threei} see if recrosses .85 again
01[11:27] {Threei} stop .95
[11:28] {cc_9} lol, even DGAZ bounced
01[11:29] {Threei} 1:2
01[11:29] {Threei} good spot nemo
[11:30] {RonS} open part doo
[11:31] {cc_9} strange, a bunch of bids just came in on just about everything
[11:33] {cc_9} DGAZ going now
[11:39] {cc_9} GILD soaring
[11:46] {cc_9} nap time
01[11:49] {Threei} Short Setup: FB .50 break
[11:53] {cc_9} most boring half Friday in a while
[11:53] {cc_9} SPY did nada
[11:54] {nemo} can't get above vwap, none of the indexes can
[11:54] {Will49} bosa nova piece spydidnada
[11:54] {nemo} looks like downside break if any
[11:54] {nemo} oh great Will is getting Ron's sense of humor
[11:55] {Will49} and proud of it
[11:55] {Will49} now if i could only trade like him
[11:57] {cc_9} This is what I'm talking about http://www.liveleak.com/view?i=299_1385428810
[11:58] {nemo} apc
01[11:58] {Threei} Invalidated
[12:04] {cc_9} glad to know you all are watching the video
[12:36] {dino} zzzzzzzzzzzzzzzzzzzzzz
[12:36] {fish_49} yea at least we got to watch a shave video
[12:36] {fish_49} CC liked the eyebrow flick perhaps
[12:36] {fish_49} lol
[12:36] {dino} going to take hour break
[12:48] {dino} insy smr l .78
[12:49] {RonS} cheater
[12:49] {RonS} 1 hr... :)
[12:50] {dino} yeah, i know...
01[12:50] {Threei} lol
[12:51] {cc_9} going to take a 3 hour break
[12:52] {RonS} lol
[12:52] {cc_9} amateur day
[12:52] {cc_9} no proper dog crash
[12:52] {RonS} going to yoga so you can do a "dog leg down"?
[12:53] {cc_9} VXX gaining some ground here
[12:54] {cc_9} GILD new session highs
[12:57] {fish_49} Nemo you around?
[12:57] {Will49} he's about 32 inches around
[12:58] {cc_9} GILD setting up for a big breakout
[13:00] {dino} insy stop -.40
[13:02] {dino} should've taken the hour break
[13:02] {Will49} do you set defined stops dino?
[13:02] {Will49} or play by ear
[13:03] {fish_49} or play by eye
[13:03] {Will49} so to speak
[13:04] {Will49} eggsaccttley fish
[13:04] {fish_49} Spy looks like it wants another leg up
[13:05] {Will49} dino either taking a break now or sitting there thinking "what DO i do anyway?"
[13:06] {dino} lol, depends on the character of the stopock, gappy ones need more leeway imo
[13:06] {RonS} if in BC or CO might be do be do be do...
[13:06] {dino} hard stop on insy would just crush you, so must manage
[13:06] {Will49} so discretionary then
[13:09] {dino} thick ones i have limits established
[13:10] {Will49} tks dino
[13:11] {dino} irwd drop
01[13:13] {Threei} LOL:
01[13:13] {Threei} Re Jan $FED hand-off, some cartoonist should draw Bernanke and Yellen in a relay race, w smiling Bernanke handing Yellen a stick of dynamite
[13:15] {fish_49} lol
01[13:15] {Threei} pretty much on target
01[13:16] {Threei} now, this one requires one additional line:
01[13:16] {Threei} House Speaker Boehner formally invites Obama to give State of the Union address on Jan. 28
01[13:16] {Threei} ...and invites South Africa sign language interpreter
01[13:17] {Threei} Long Setup: LULU 59 break
01[13:17] {Threei} If holds .90
01[13:18] {Threei} btw will... you still doubt that parcel safe arrival? it's been two more winning trades since you questioned it
[13:19] {Will49} i'm sold!
[13:19] {Will49} and i was being facicious too
06[13:19] * Threei crosses one more skeptic out of the lost, before handing list to nemo
01[13:19] {Threei} list
01[13:19] {Threei} see... you may have just saved your life {G}
01[13:20] {Threei} nemo finally got that license
[13:21] {Will49} sorry Vad..can't type too well with right finger on "hover" button
[13:22] {Will49} hey ron...i'm practising hovercraft
[13:22] {cc_9} what a boring freaking day
01[13:22] {Threei} so the best time to insult you with no pushback... got it. writing it down
[13:22] {cc_9} im about to amputate a finger out of boredom to see what happens
01[13:23] {Threei} whose, cc?
[13:23] {cc_9} my own
[13:23] {Will49} want to know what to do with it after you cut it off?
01[13:23] {Threei} I thought some neighbor was careless enough to wander by
[13:23] {cc_9} go fishing
[13:23] {Will49} that'd work
[13:25] {fish_49} yuck
[13:25] {cc_9} SPY volume is a total joke
[13:25] {cc_9} might as well ring the bell now
01[13:26] {Threei} be back in 30
[13:27] {cc_9} be back in 3,000
[13:28] {Will49} haha
[13:28] {Will49} i'll laugh at anything today
[13:28] {cc_9} The Healthcare System is working
[13:28] {cc_9} hahahahaha
[13:29] {cc_9} laugh with me
[13:29] {cc_9} hahaha
[13:29] {cc_9} holy shit
[13:29] {cc_9} so funny
[13:29] {cc_9} brb
[13:29] {Will49} hahahaha
[13:29] {Will49} rediculous
[13:30] {Will49} hey fish...do you think Vad put a hrad buy stop on LULU?
[13:30] {Will49} hard
[13:31] {fish_49} lol
[13:32] {fish_49} I'm sure he has his secretary taking care of it while he changes batteries in his camera
[13:32] {Will49} maybe he's onto the OCA technique that cc suggested
[13:33] {fish_49} OCA? Order Cancels All?
[13:33] {Will49} yes
[13:33] {Will49} one cancels all
[13:34] {Will49} http://www.youtube.com/watch?v=yYSXRbXg-pY
[13:36] {fish_49} yea OCO
[13:36] {fish_49} I use them
[13:36] {Will49} yeah..cancels "other"
[13:37] {cc_9} Once Cancels Other
[13:37] {fish_49} correct on my platform they are used for two reasons
[13:37] {fish_49} 1. if your in the trade and forgot to place target and stop
[13:37] {fish_49} or 2. Wrap orders around a break out or break down which ever hits cancels the other
[13:37] {Will49} neat
[13:38] {cc_9} OCO is a very useful tool, glad to see someone using it
[13:38] {fish_49} that is the class I teach once in awhile at the training center I attend
[13:39] {mrcanada} hi....
[13:39] {fish_49} on TS its point and click no keying in info
[13:39] {fish_49} MRC how are u today
[13:39] {Will49} hey mrc
[13:39] {Will49} comment ca va?
[13:39] {mrcanada} parlez francais?
[13:40] {Will49} un put
[13:40] {Will49} is that right?
[13:40] {mrcanada} un petit peu?
[13:40] {Will49} yes
[13:40] {Will49} high school French long time ago
[13:41] {mrcanada} k....had to go out and split some wood to keep my little shack warm....minus 22 with the wind chill
[13:41] {Will49} ouch
[13:41] {Will49} 9C here today
[13:41] {Will49} +9
[13:41] {mrcanada} right now the sun is heating us....its 26 Celsius in the sunroom....
[13:42] {mrcanada} +9...I'd probably be golfing
[13:42] {Will49} all year 'round here
[13:42] {Will49} gets a bit wet at times though
[13:42] {mrcanada} that's what I hear....
[13:43] {mrcanada} so was trading good this a.m.?
[13:43] {Will49} depends who you ask
[13:43] {mrcanada} I am asking you...
[13:43] {Will49} very goos tks
[13:43] {Will49} good
[13:44] {Will49} 3 wins no losses
[13:44] {mrcanada} great....
[13:44] {Will49} Vad had 4 wins 1 loss i think
[13:44] {mrcanada} kind of like what the canucks wished too
[13:44] {Will49} sheesh...don't get me going
[13:45] {mrcanada} the Sens stink this year too
[13:46] {Will49} Canucks have too many big contracts feeling secure
[13:46] {Will49} Sedin twins are coasting IMHO
[13:46] {nemo} the Sedin sisters?
[13:46] {Will49} LOL
[13:46] {Will49} that's it nemo
[13:46] {mrcanada} Luongo....?
[13:47] {nemo} when Bruins kicked their ass a few years back local scribe coined the term
[13:47] {Will49} he's still motivated to win
[13:47] {Will49} yeah...he was right on
[13:48] {mrcanada} the Bruins still have a very good team
[13:48] {Will49} true dat
[13:48] {nemo} pretty beat up right now
[13:48] {Will49} Vancouver is looking like Toronto in that they fill the rink every game
[13:48] {Will49} owners don't need to work at the business at all
[13:49] {mrcanada} my brother use to be a team dr. for the Leafs
[13:49] {Will49} really?
[13:49] {mrcanada} yep
[13:49] {Will49} name?
[13:49] {Will49} Had season tickets to MLG for twenty years
[13:49] {mrcanada} all the dr.s that work for them don't get paid....just get to put it on their CV
[13:50] {Will49} ahhh
[13:50] {mrcanada} they get 2 tickets to every home game
[13:50] {Will49} yeah i remember now..they just call them over PA
[13:50] {mrcanada} we got to sit right behind the leaf's bench....these are the kind of tickets that are inherited in estates
[13:50] {fish_49} just got the first captured video of Kim Jung Un Killing his Uncle
[13:50] {fish_49} lol
[13:50] {Will49} had first-row end blues...perfect for an old goalie
[13:50] {fish_49} http://s1332.photobucket.com/albums/w611/bkhmd/?action=view¤t=kimJungUn_zpse9b90573.mp4
[13:51] {mrcanada} was Dennis Rodman giving him advice?
[13:51] {RonS} nutz lost track of lulu and missed...
[13:51] {Will49} me too...craaaaap
[13:51] {Will49} had a hard buy on and it blew right past it
[13:52] {fish_49} hover craft not working?
01[13:52] {Threei} back
01[13:52] {Threei} LULU baby
[13:52] {Will49} din't use hover that time
[13:53] {Will49} sorry teacher...we kids were messing around and missed an entry
01[13:54] {Threei} stand in the corner, say hail mary 5 times, drink 3 ounces of vodka straight
[13:54] {Will49} talkin' hockey and such s*&^%t
[13:54] {fish_49} not too late buy it now so I can get out
[13:54] {fish_49} lol
[13:54] {fish_49} lol
[13:54] {Will49} oooo, that sounds like fun
01[13:55] {Threei} wait, best part is ahead
01[13:55] {Threei} ... go shake hands with Rob Ford, whether he wishes to do so or not
[13:55] {Will49} he might knock me over
01[13:56] {Threei} well, this is punishment, isn't it
[13:56] {Will49} right over my head Vad
[13:57] {Will49} the other part of the punishment is having to fly Air Canada to Toronto
[13:58] {Will49} flying Westjet to Maui this time even though it's more expensive
01[13:58] {Threei} yup... no westjet
[13:59] {fish_49} If available grab Asiana Air...
[13:59] {Will49} not from here fish
[13:59] {fish_49} ahhhhh
[13:59] {Will49} but i hear good things
[13:59] {Will49} have a daughter living it Taipei who likes them
[14:00] {fish_49} yea I normally fly United however, if I get a chance to fly Asiana I take it. Great service, better comfort and they are in the Star Aliance with Air Canada
[14:01] {fish_49} alliance*
[14:01] {Will49} pitty them
[14:01] {fish_49} corrected b4 nemo can see it
[14:02] {Will49} nemo=grammar police
[14:02] {nemo} pity
[14:02] {Will49} see
[14:02] {nemo} that's spelling dude
[14:02] {fish_49} nemo what is S1 and S2 for spy today
[14:02] {Will49} he's always watching
[14:02] {Will49} see
[14:02] {nemo} S1=177.647
[14:03] {nemo} S2=177.15
[14:03] {nemo} I think we've topped out on the indexes for the day
[14:03] {fish_49} I have an indicator on my platform for floor trader pivots
[14:04] {fish_49} wanted to see if accurate
[14:04] {dino} 07 red
[14:04] {nemo} likely are, have to find out from where the data is pulled and what calculations they are using
[14:05] {fish_49} it shows S1 at 178.27
[14:05] {nemo} what platform?
[14:05] {fish_49} Trade Station
[14:05] {nemo} mmmhhhh
[14:05] {fish_49} and showing S2 at 178.03
[14:06] {nemo} I'm looking at freestockcharts, and on my spreadsheet, which pulls data from yahoo, they are the same
[14:07] {fish_49} if on a 5 min char it's numbers match up with the numbers you gave me
[14:07] {nemo} time should be irrelevant to pivot calculations
[14:07] {fish_49} I agree
[14:07] {nemo} unless, the pivots are dynamically developing
[14:07] {fish_49} we just pierced S2?
[14:08] {nemo} that Pivot Boss guy has an indicator that calculates pivot levels throughout the day-Ochoa, it might be part of their package
[14:09] {fish_49} Resistance Level 3 = R3 = R2 + YestHigh - YestLow
[14:10] {nemo} my r3 =H+2*(PP-L)
01[14:14] {Threei} ugh... was looking at FB for 53 short
[14:15] {Will49} go stand in the corner
[14:16] {nemo} what up with adbe?
01[14:16] {Threei} good report, upgrade
[14:17] {cc_9} THE DOG CRASH
[14:17] {cc_9} THE DOG CRASH IS HERE
01[14:17] {Threei} guidance looks lousy though
[14:17] {cc_9} YIPEEEEEEEE
[14:17] {nemo} o.k. Steve
[14:18] {fish_49} thanks Nemo Got it to plot auto mode
[14:19] {nemo} ahhhh
[14:20] {fish_49} vad did you see my video of Kim Jung Un Killing Uncle?
01[14:21] {Threei} no
01[14:21] {Threei} where?
01[14:21] {Threei} 1:2, LULU
[14:21] {Will49} in N Korea
01[14:21] {Threei} ah
01[14:21] {Threei} helpful
[14:21] {fish_49} http://s1332.photobucket.com/user/bkhmd/media/kimJungUn_zpse9b90573.mp4.html
01[14:22] {Threei} or as dini would say, value added
[14:22] {fish_49} lol Will
[14:22] {fish_49} not sure if it will play
01[14:22] {Threei} lol, it did
[14:22] {fish_49} Only in North Korea can you kill your uncle and tell everyone
[14:23] {fish_49} Even Putin would Kill his uncle but he would Deny it and say it was CIA hit
01[14:23] {Threei} and in Ukraine you can win election and immediately put your opponent in jail
01[14:24] {Threei} and it's all fine, because you after all won, right?
[14:24] {fish_49} yea It's not Kim Jung Un's first execution. His X Girlfriend wouldn't serve him properly (We all know what he wanted) and he had her killed
[14:25] {dino} you mean "service"
[14:25] {nemo} can't blame him
[14:26] {fish_49} yea Dino something to do with the name of a bird
[14:26] {fish_49} Swallow
[14:26] {nemo} doubt it was the stork
01[14:26] {Threei} Short Setup: ADBE .50 break hl
01[14:27] {Threei} If holds .60
[14:27] {nemo} gonna' bounce here
01[14:29] {Threei} Snow is Australia summer. Snow in Egypt. Heavy snow in Israel. Where is Al Gore?
[14:29] {fish_49} I cant short ADBE I have a long positon
01[14:29] {Threei} get second broker
[14:29] {nemo} I'm getting a JD position
[14:29] {fish_49} yea I should some people mentioned that so I could short term short while in a longer term long
01[14:30] {Threei} Federal officials to announce arrest of Kansas man who wanted to set off a suicide bomb at the Wichita, Kan., airport
01[14:30] {Threei} get cc9 to furnish you with low finds high BP account
[14:30] {fish_49} was that the big FBI news scheduled for today?
01[14:30] {Threei} use it for quick day trades
[14:31] {dino} it was only a matter of time for suicide bombers to show up here
01[14:31] {Threei} keep slower account for swings
[14:31] {fish_49} I tried that platform I'm not knocking it, just not for me
[14:31] {nemo} wish they'd show up in Brookline, Newton, Cambridge, Harvard....
01[14:31] {Threei} yeah dino, and just wait till they start going for soft targets...
[14:31] {dino} fish, thats what i am doing w/two accounts. started end of nov.
01[14:32] {Threei} what do you need for a platform, fish? other than lightning quick executions and accurate quotes
01[14:32] {Threei} from
[14:32] {dino} ironically, the daytrading account is destroying the swing account
[14:32] {nemo} just because the market been so choppy of late dino
[14:33] {fish_49} I just really prefer Tradestation's Matrix for order entry
[14:33] {dino} and have to give cc9 credit, that das trader is fast
[14:33] {nemo} fish.....
01[14:33] {Threei} yikes
[14:33] {nemo} how many platforms you tried?
[14:33] {fish_49} yes fast and instant
[14:33] {fish_49} I'm not saying anything bad
[14:33] {fish_49} just personal preference
01[14:34] {Threei} it's anything but instant when you have right one for comparison... :)
[14:34] {fish_49} MB trading which is very close to DAS
[14:34] {nemo} Vad would know
[14:34] {fish_49} Trade Station, and street smart pro
[14:34] {nemo} adbe teleport
[14:34] {Will49} jeeeze
[14:35] {nemo} had that look
[14:35] {fish_49} I mean DAS Vad )Instant) that is the one thing about it is almost instant fills
[14:35] {nemo} could almost see that coming
01[14:36] {Threei} TA ia about IB level fills speed wise
[14:36] {dino} fish, using stsmartedge for swings, charts, scanners, news. das for daytrades
01[14:36] {Threei} TS
[14:38] {fish_49} what is IB Vad
01[14:38] {Threei} International Brokers
[14:38] {fish_49} yes that is what I have used b4 Edge (SSE) I like it except the Charts
[14:38] {nemo} Interactive
01[14:39] {Threei} right
[14:39] {fish_49} lol
[14:39] {nemo} just testing us, I know
01[14:39] {Threei} ADBE... 1:3... grrr
[14:39] {nemo} Friday afternoon=vodka=Vad
[14:39] {nemo} although it's only 11 there
[14:40] {dino} basketball night here. daughter jr 8th grade game, son varsity game
01[14:40] {Threei} can't... got a doc visit 30 min after market close
[14:40] {nemo} it'll thin your blood
[14:40] {Will49} did you get to keep your doc vad? :)
01[14:40] {Threei} he won't appreciate drunk patient I guess
01[14:40] {Threei} lol will
[14:41] {nemo} 59.70 target for adbe
[14:42] {Will49} now that we know NSA got our guys to spy for them, we'll be forced into Obummer care before we know it
[14:42] {nemo} start stretching you'll need to be able to grab your ankles
[14:43] {Will49} our tax system has already taught us that skill
[14:43] {nemo} well, at least nobody hears when you fart then
01[14:43] {Threei} Long Setup: ABDE .25 break hl
[14:44] {dino} lol
[14:44] {nemo} wow
01[14:45] {Threei} If holds .15
01[14:45] {Threei} so, between O ever-increasing taxes, Kim shooting and Yanukovich jail time, doesn't Harper start looking good?
[14:45] {dino} charlie harper?
01[14:45] {Threei} 1:1
01[14:45] {Threei} lol
01[14:46] {Threei} that one looked good always
[14:46] {dino} letting him go has ruined that show.
01[14:46] {Threei} yeah, went to dogs
01[14:46] {Threei} his new one isn't stellar either\
[14:47] {dino} better than 2 1/2
[14:48] {nemo} wow
[14:48] {nemo} glass of JD just appeared on my desk
01[14:48] {Threei} magic?
[14:49] {nemo} must be
[14:49] {dino} lucky dog
[14:50] {nemo} now if the girlfriend would stop by
01[14:50] {Threei} lemme try...
06[14:51] * Threei says loudly "Bottle of Glenlivet, I command you to come forth right now"
01[14:51] {Threei} hmmm... nothing
[14:51] {nemo} it's all about the Qi, Vad
01[14:52] {Threei} lend me some?
[14:52] {nemo} btw...this might be a good place to go short adbe
01[14:52] {Threei} mine is all tied uo to fend off the doc later today
[14:52] {nemo} mmmhhhhh
[14:52] {Will49} just hope the doc is out of rubber gloves
[14:52] {nemo} I'll leave that alone
01[14:53] {Threei} nah, we are just friends
[14:53] {Will49} lol
01[14:54] {Threei} not that he didn't try to get friendlier but displaying 2x4 prominently when marching in his office did the trick
[14:54] {Will49} large trout would work too
[14:55] {cc_9} sup
[14:56] {dino} 'sup w/you?
01[14:56] {Threei} may the Sup be with you
[14:56] {Will49} :)
01[14:58] {Threei} 1:2
[14:58] {cc_9} not much , eyeing P here for a bounce
01[14:58] {Threei} this one you couldn't have missed, will
[14:59] {Will49} no didn't
[14:59] {Will49} it moved slowly enough for me that time
[15:00] {Will49} and stop pickin' on me Vad :)
01[15:00] {Threei} heck, it was slow enought o TS users to get {GGG}
[15:00] {cc_9} Stays the used Japanese school girl panties dispenser user
[15:00] {cc_9} says*
[15:00] {fish_49} Grrrrr
01[15:00] {Threei} see? switching picking to others :)
[15:00] {cc_9} wait, was that Fish or Will
[15:00] {cc_9} eh, both
[15:00] {fish_49} hard to pick on a fish
[15:00] {fish_49} I have scales
[15:00] {cc_9} you creeps
01[15:01] {Threei} lol
[15:01] {nemo} I have a rabbit
01[15:02] {Threei} but you are a fish... lost one, too
[15:03] {nemo} who u talkin' 2?
01[15:04] {Threei} you
[15:04] {nemo} wow...miraculously that glass of JD is empty
[15:04] {nemo} the
[15:04] {nemo} Immaculate Consumption
01[15:05] {Threei} holy grail of all consumptions
[15:05] {nemo} The Shambala of Baccanalia
[15:06] {nemo} Bachanalia (?)
[15:06] {Will49} you mean you can't spell THAT?
[15:07] {fish_49} JD JDente what happened to him
[15:08] {nemo} Bacchanalia
[15:08] {nemo} Fish, you obviously haven't been following the dialogue
[15:08] {Will49} i knew that (cc)
[15:08] {fish_49} No I was busy
[15:08] {fish_49} Just seen JD and remembered a JD in this room awhile back
[15:08] {cc_9} GILD is trying to orangutan
[[15:13] {fish_49} What did Vad say the other Day? I don't know any of you
[15:14] {nemo} Fish, notice how I never say anything about when I'm near Maryland?
[15:14] {cc_9} GILD making a goat run
[15:14] {fish_49} no I didn't notice
[15:14] {fish_49} lol
[15:15] {Will49} fish..nemo's on his third glass of JD
[15:15] {nemo} Yeah, was down your neck of the woods over Thanksgiving
[15:15] {nemo} 1st
[15:15] {fish_49} Thought I smelled something
[15:16] {Will49} sounds like your third (lick?)
[15:17] {cc_9} GILD going for it
[15:18] {Will49} Vad..looks like some serious blog editing for you today
[15:19] {Will49} mrc..private line
01[15:20] {Threei} I've no time nor desire for that...
[15:21] {Will49} maybe you'll attract a new bunch of gypsy vagabonds to the room
[15:21] {Will49} if you leave it as is
[15:21] {fish_49} lol
01[15:21] {Threei} we don't mind those, do we
[15:22] {Will49} cc is the only non-gypsy here
[15:22] {fish_49} The one guy that told me he was going to sign up in the room was an old presidential appointee from the GW Bush days
[15:22] {fish_49} his assignment was something to do with world religious freedoms
[15:22] {fish_49} so I warned him ahead of time about Nemo
[15:23] {Will49} haha
01[15:23] {Threei} he was assigned to keep them aor to eliminate them?
[15:23] {cc_9} GILD the goat that could outrun a horse
[15:24] {dino} how'd we miss trla today?
[15:24] {fish_49} he went around the world and beggd world leaders to be more liberal on religion is what he said
[15:25] {dino} yeah, that did alot of good, sheesh
01[15:25] {Threei} begging always does
[15:25] {Will49} did he get to the Vatican?
01[15:25] {Threei} it's the most effective way to get anything out of world leaders
[15:25] {fish_49} I didn't talk to him much he was a bit
[15:26] {RonS} ...works with wives as well...
[15:26] {fish_49} well I should not say he might be reading logs
[15:26] {fish_49} lol
01[15:26] {Threei} Pussy Riot begs for forgiveness for 2 years, and there you go, court reviews their case
[15:26] {Will49} Pussy is agnostic
01[15:26] {Threei} but Riot isn't
[15:26] {fish_49} hahahahahahaha
[15:26] {fish_49} TGIF
[15:27] {Will49} yeah...we all need a couple of days off
[15:27] {cc_9} GILD goating
[15:28] {fish_49} I finished well into the black this week ... Thanks Vad
[15:28] {fish_49} Im gonna swim away
[15:28] {fish_49} see you guys in a few weeks
[15:28] {Will49} keep your gills open
01[15:28] {Threei} good job fish'
[15:28] {dino} cya fish
01[15:28] {Threei} take care, safe travel
[15:28] {Will49} upstream
[15:36] {RonS} sheesh...active shooter inside the local high school my daughter went to...
[15:36] {Will49} yikes
[15:40] {dino} calling it a week, very good one. thx for ideas all
[15:41] {Will49} peace dino
01[15:41] {Threei} ok guys, let's call it a week
01[15:41] {Threei} ending on a very good note
[15:41] {Will49} yeah let's
[15:41] {Will49} see ya all monday
01[15:41] {Threei} thank you all, have a great weekend
[15:41] {Will49} good day
01[15:41] {Threei} see you Monday


text:
All You Need To Know About India's 4th Gold Medallist 'Ragala Venkat Rahul' | Cinemaizm
All You Need To Know About India's 4th Gold Medallist 'Ragala Venkat Rahul' | Cinemaizm
Commonwealth Games 2018 start ayinapattinundi andari drusti tana mede, elaganna esari manalni tala ettukune chestadu ani yavath bharadhesam eduru chusindi. Anukunatu gaane, tanu gold medal gelichi mana tri-colour flag inka proud feel ayyela chesadu. He is none other than 21-year old Ragala Venkat Rahul.
He became India's 4th gold medallist at Commonwealth Games 2018. He participated in the 85kg category of weightlifting, Rahul lifted a combined total of 338 kg (151 kg in snatch and 187 kg in clean and jerk) and tops the list. Since the day 1, Rahul e games lo andari surprise chestu manchi form lo unadu.
Rahul hailed from the Guntur district of Andra Pradesh. Rahul puttindi Stuartpuram, ani AP lo unte oka small place lo and e place quite popular for its crime rate. Asalu weightlifting ki tinu introduce aindi and training anta complete chesindi Telangana Sports School, Hyderabad. His father, Madhu Ragala, was a former kabaddi player and weightlifter who had to give up on his dreams due to poverty. Tana lage, tana koduku kuda ala akadito agipodadani, tanani e school lo cherpinchalani chala try chesaru. But admission test fail ayadu, with the help of Manikyala Rao, coach of the sports school, he got admission into it. School level tarvata chala ibbandulu padadu.
At the age of 17 years, Rahul, youth and junior categories of the Commonwealth Youth and Junior Weightlifting Championship 2013 lo gold medals sampadinchi tana first international level competitions lo success ayadu. And Rio Olympics ki prepare avtuna time lo, vala mother ki health issue ravadam valla, he didn't prepare well and lost the chance. And adi chala disappointment time Rahul ki. But ala ani ekkada nirutsaha padakunda, inka chala kastapadi prepare ayadu.
His inspiration is Karnam Malleswari, India's first ever woman medallist in the Olympics (Bronze, Weightlifting, 2000 Sydney Games). Asalu Karnam Malleswari gari valle, he got entered into the world of weightlifting.
2017yr lo Commonwealth Senior Weightlifting Championship avadatam valla 2018yr lo jarigina commonwealth game lo select ayyadu. Mokali noppitho badapaduthunna Rahul Gold Coast lo jariguthunna match lo palgonnadu. Kaani asalu confidence pokunda, chala kastapadi, e games lo heart and soul peti adadu and gelichadu.
Vela father Rahul tho agipokunda, tana tammudu Varun ni kuda weightlifting training ipistunadu and he is also making the country proud. The Andra Pradesh Government was highly pleased with the 21-year-old's surging talent and success, rewarded Rahul with Rs 15 lakh rupees and also Pawan kalyan rewarded with Rs 10 lakhs on behalf of Janasena party. Athani anthima kala Olympic medal sadinchindi.


text:
Nile Cruise
Honey Moon Trip
Holly Family Trip
Customize Tour
Cairo package
Duration: 5 Days /4 Nights
Itinerary: Giza – Cairo –Alexandria
Day 1 : Arrival Cairo.
Upon your arrival at Cairo international airport you will be welcomed by our Representative meet and assist then transferee to your hotel overnight in Cairo.
Day 2 : Pyramids Day.
After your breakfast ,you will start your tour with a professional guide visit the giza pyramids the three pyramids of Cheops and khefren and macrenus enter the second pyramid then visit the great Sphinx ,from Giza move to Sakrra have lunch on the way in a local restaurant at Sakrra enjoy the step pyramid the oldest of the Egyptian pyramids then enter very amazing pyramid the pyramid of king Titi of the 5th dynasty where you can see hieroglyphic inscriptions called (pyramids' texts) a magical spells then visit one of the tombs at Sakkara then visit the museum of vizier Imhoteb.
Move from Sakkara to Memphis on the way stop at The famous carpet school where you can see how very young children wave a handmade carpets then continue your tour to one of the oldest city in the world Memphis enjoy the colossi of Ramses the great and the Alabaster Sphinx then back to your hotel at night you have an optional to join the sound and light show at the pyramids and dinner at a local restaurant.
Day 3 : Alexandria.
Today we will visit Alexandria the second capital of Egypt Alexandria sightseeing visit the catacomb tomb and pompay pillar enjoy the Qitbay citadel from outside enter the library Biblotica Alexandrina have lunch at a local sea food restaurant then back to Cairo.
Day 4 : Cairo.
Today we will visit the sightseeing of Cairo start with the Egyptian museum enjoy the treasures of the golden tut ankh amon then visit the Coptic Cairo discover the place where the holy family had a refuge during their flee to Egypt, then move to the citadel visit the alabaster mosque and then move to the Islamic Cairo enjoy the biggest collection of the Islamic architectures in the world (Moeaz Street) ends by the medieval Bazaar of Cairo ,, have lunch in a local restaurant.
Day 5 : Departure.
After checking out from your hotel free till your flight time ,, you will be transferred by our Representative to the airport.
Terms & conditions
All the transportations and transferees during the tour.
Accommodations based in B &B .
lunch during the tour.
Professional Guide.
All taxes .
the entrance fees of the sightseeing.
the international flight ticket
the entry visa of Egypt if required only 15$ per person.
any extra or optional tour not mentioned
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text:
Home > Flute & Piccolo
An assortment of 19 fun pieces to pick and mix - from easy classics to great new pieces, this collection covers it all! 'All Sorts' is designed to fit the technique and capabilities of the young players, with easy-to-play piano accompaniments for the teacher.
Bar Code: 9780571521234Part Number: 521231Brand: Faber Music


text:
Resume Tips for Travel Healthcare Professionals
Your resume is one of the keys to success in your career and healthcare job search, so there is no better time than the present to implement these following Traveler resume tips to make yours stand out from the crowd.
Download Medical Solutions Resume Template
- Provide a Summary of Qualifications that provides an overview of why you are the best candidate for the job.
- Keep it short and concise. Use bullet points to make it easy for a hiring or nurse manager to quickly scan.
- Use easy-to-read fonts.
- Spell check.
- Use a professional email address. Keep it simple — using your name is best.
- Use chronological order in listing your past jobs.
- Keep your resume updated after each assignment.
- List the type of facility you worked at when listing your jobs i.e. Magnet, Teaching, Trauma, etc.
- Use keywords you know employers will be looking for when they search for candidates online. For example, don't just type Emergency Room, instead put Emergency Room (ER).
- Spell check (again).
- Keep in mind traveling healthcare requirements and your healthcare skills checklist when displaying what you have to offer professionally.
- Be detailed and thorough, but keep your resume to a minimum of two pages.
- Highlight your licenses, certifications, and academic achievements.
- Add an Expertise Section that lists your key healthcare skills in your specialty. You also want to highlight how your track record, experience, and certifications specifically align with traveling healthcare requirements.
- List specific contributions you have made to each employer like training programs you spearheaded or practices you help put in place.
- Include any volunteer work you have done that you think uniquely qualifies you for the job. Let your personality shine through, briefly include a short section about your interests relating to your profession.
-Katie R.
Hello Freedom
Apply now and take the fast track to starting your career as a Travel Nurse.


text:
Wednesday, February 28, 2007
Private schools to remain fiefdoms
Surprise, surprise, Uri lawmakers have agreed to abandon their extremely modest gesture toward making the administration of private schools more transparent and accountable. This is bad news for teachers and students, but great news for GNP politicians, many of whom rely on "donations" from private school directors to fund election campaigns.
Note to Jung Sung-ki and the Korea Times: when combatants (e.g. sergeants in an occupying military force) are killed, they are NOT "victims of terrorism," even if it is sad. When NON-combatants are killed, THEY are victims of terrorism. You newspeaking weasel hacks.
3 comments:
- Anonymous said...
This is something that really winds me up. And it wasn't just Korea Times by any means, Hankyoreh constantly used the word 'terror' in its reporting on the attack. By any normal definition of terrorism you cannot call an attack on a military base (and CIA torture centre) a terrorist attack. It is a straightforward military assault. Fortunately, however bad much of their reporting is, the BBC has a policy of avoiding the word terrorist altogether, so their report on the Cheney attack doesn't use the word.
- 5:52 p.m.
- Andrew Thomas said...
It's as if they're using dictionaries provided by the Pentagon or the SIS. Why pay companies like the Lincoln Group when mainstream media outlets are already playing along?
Some call it MindWar (.pdf) .. if Gramsci were alive today ..
- 6:31 p.m.
- sam59527 said...
- 3:03 p.m.