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Our Tours
See the itinerary for some of our popular tours below.
About Nutshell Guides
Nutshell Guides is a concept by Kim Riddell, a Blue Badge Guide, Tour Manager, Tour Planner & Organiser.
I have been a Tour Guide and Tour Manager since 1991 and I work throughout Europe and the UK & Ireland. I have a Blue Badge Guide qualification for the heart of England area.
I am often asked if I have a favourite place, and I always have to think. Travel is something I wanted to do from an early age and everywhere has something that is interesting and unique so my usual answer is "wherever I happen to be"
But as I chose the Stratford Upon Avon district as my home, the real answer has to be "Here" I have guided special interest groups, and general tourist groups, of all ages, backgrounds and nationalities – I am always proud and happy to be able to deliver a successful tour which they all enjoy – especially when they say they have learned something new. Travel should always be fun and interesting.
My own interests are many and varied ; Literature. I love to visit the places where the writers and artists lived, the places that inspired them. Gardens – though far from green fingered myself, I love to see beautiful landscapes and planted gardens – hoping that somehow the prowess of the creators will wear off on me! Art, architecture, Movie and TV locations, and of course the history of our great country. It's wonderful to be able to combine the realm of the imagination with the fabric of our own history and landscape, to create a fun and exciting tour.
Offering a bespoke service tailored to individual group needs is a speciality and the opportunity for raising revenue for charity is also a consideration.
The Nutshell Blog
Travel articles, notes and stories from our guides.


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Theravance Biopharma Announces Alignment of Workforce with Focus on Key Strategic Priorities
"Our portfolio has evolved over time, most recently with the approval and commercial launch of YUPELRI™ (revefenacin) plus the advancement of TD-1473 and ampreloxetine (TD-9855) into late-stage development programs. At this juncture, we concluded it was prudent to focus resources on our late-stage research projects and translational science, late-stage development pipeline, and the commercialization of YUPELRI™," said Rick E Winningham, chairman and chief executive officer of
In our relentless pursuit of this objective, we strive to apply insight and innovation at each stage of our business, including research, development and commercialization, and utilize both internal capabilities and those of partners around the world. Our research efforts are focused in the areas of inflammation and immunology. Our research goal is to design localized medicines that target diseased tissues, without systemic exposure, in order to maximize patient benefit and minimize risk. These efforts leverage years of experience in developing localized medicines for the lungs to treat respiratory disease. The first potential medicine to emerge from our research focus on immunology and localized treatments is an oral, gut-selective pan-Janus kinase (JAK) inhibitor, currently in development to treat a range of inflammatory intestinal diseases. Our pipeline of internally discovered product candidates will continue to evolve with the goal of creating transformational medicines to address the significant needs of patients.
In addition, we have an economic interest in future payments that may be made by
For more information, please visit www.theravance.com.
THERAVANCE® and the Cross/Star logo are registered trademarks of the
This press release contains certain "forward-looking" statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives, expectations and future events.
Contact Information
View original content to download multimedia:http://www.prnewswire.com/news-releases/theravance-biopharma-announces-alignment-of-workforce-with-focus-on-key-strategic-priorities-300773955.html

subset: commoncrawl


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,,,,,,,,,,,,,,,,,,,,,,,,,,Life goes on ,,,,,,,,,,,,,,,,,,,,,,
The wisest thought
and safer
stay looking for
. a New Amor,
. if it ran away,
wherever it is.
But I still love him,
support with pain,
. what's surprising
. if this is that
that then fans all.?
And you
best wishes to you,
for a love
that makes you suffer
to leave you
still love him?
What good it would be
if those
that no longer have Love
. they should wish
to die ?
Therefore, console
even when
if he had gone,
continue your life
without anguish
and sometimes in the Sky
turn your face.
If we have against
an unjust fate,
it is necessary, silent,
. accept everything,
but you do not resign yourself
indeed you are rebel.
But this does not work,
why go
against Destiny
can bring
to bitter conclusions.
. All rights reserved
copyright @
Author Stefano Capasso
Images from the Web.


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Men from low-income families are almost twice as likely to be unmarried than those from wealthy families by the time they reach the early 40s, a study has found.
Aside from being likely to be in a highly-paid work or even having any work at all, wealthier men in their early 40s in Britain are also more likely to be living with a partner, according to the study from the Institute for Fiscal Studies (IFS).
The findings reveal the probability of being in a relationship, and a partner's income, are becoming more important to family background.
In 2012, about one in three, or 33 percent of men aged 42 from the poorest fifth of families lived without a partner, the analysis discovered – compared with one in seven or 15 percent of their equivalents from rich families living without a partner.
Men from not very wealthy families were more than two times as likely to be seperated compared with those from high-income families, at 11% versus 5% and nearly twice as probable of never getting married, at 36% versus 20%.
Aside from spousal problems, richer men were also more likely to have partners who earn more. The partners of men from richer familied seemed to earn about 73% more than the partners of men from poorer families, the study has revealed.
As women's income are an getting an important role of a family's earnings, these significantly lower the family incomes of men who grew up in low-income households compared with those men who grew up in rich families, the IFS stated.
The study says this is considered a "new divide". Amongst men born 12 years ahead, the disparities in partnership status and partner income by family history were almost unnoticeable, the IFS stated.
In 2012, 42-year-old men with jobs whose parents were amongst the wealthiest fifth of households received on average 88% higher than those from the underprivileged families. In 2000, the difference was just 47%.
Men from low-income families were twice as likely to be out of a job as those from well-off households.
A research economist at the IFS and an author of the paper stated: "Focusing solely on the earnings of men in work understates the importance of family background in determining living standards.
"As well as having higher earnings, those from richer families are more likely to be in work, more likely to have a partner and more likely to have a higher-earning partner than those from less well-off backgrounds.
"And all these inequalities have been widening over time."
Alison Park, referring to the study, said: "It shows how existing differences in the earnings of men from richer and poorer backgrounds are exacerbated by a new divide, with poorer men in their early 40s being less likely than those from wealthier backgrounds to be living with a partner."


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Endive Reblochon Tatin - Bruno Albouze - THE REAL DEAL
Endive Reblochon Tatin Recipe
Serves 8. Excellent into small portions as appetizers or wine tasting or served as an entree.
Pie Dough / Pâte Brisée
1.9 cups (250g) all-purpose flour
1.1 sticks (125g) butter, cubed and cool
1 tsp (4g) salt
1 (50g) whole egg
2 Tbsp (30ml) water or milk.
Using a food processor, mixer or by hand, sand flour, salt and butter. Add the egg and water and mix to combine. Wrap up and chill. Use two-third of the dough and roll out into a 1/4 inch (5/6mm) thick disk and about 0.5 inch (1.25cm) larger than the mold. Prick and freeze for 20 min or more.
Preheat oven to 350ºF (180ºC). Top crust with parchment or silicone mat and a baking tray. Bake for 25 min, cut disk the size of the bottom pan or dish used for the tatin. Put back in the oven with the tray on top and bake for 10 minute more or until golden brown. Cool and set aside.
≈ 10 ea. Belgian endive.
1 ea. Reblochon cheese* (camenbert size wheel), room temp
1/4 cup (50g) sugar for caramel a sec
1/2 Tbsp (8ml) molasse (optional)
1 Tbsp (15ml) balsamic vinegar or lemon juice
2.8 Tbsp (40g) butter, cubed and cold
1/2 Tbsp (8ml) olive oil
6 garlic cloves, crushed
Salt and black pepper to taste.
*Reblochon is a soft washed-rind and smear-ripened French cheese made in the Alpine region of Savoy from raw cow's milk. It has its own AOC designation. Unfortunately, it can't be found in the US. Its closer friend would be the Willoughby cheese made in USA. Fourme d'Ambert or goat cheese can also be great subs…
Remove endive outer leaves and clean using a wet paper towel. Remove core and split each endive in half. Meanwhile, heat up a non-stick frying pan and cook sugar to caramel stage (no water needed), lower the heat and stir in butter and molasse. Turn heat off and arrange endive halves into a sunflower (cuts side down). Spread crushed garlic (skin on) and season with balsamic, salt and pepper. Put the lid on and cook on stove or bake in the oven for 25 minutes at 350ºF (180ºC). Remove the lid and continue to cook for 45 min more. Remove and save excess juice and reduce it in a small saucepan until syrupy consistency; set aside.
Squeeze out roasted garlic flesh from skin and puree; reserve. Now, the endives are still wet but will begin to sear and caramelize quickly, do so and turn the heat off when color is achieved (do not burn though).
Endive Tatin Assembly
At this juncture, the endive tatin can be finished right from the frying pan or as shown in the video using a cake mold for best results.
Flip over caramelized endives onto a plate (endive cuts side up). Top with plastic wrap and flip again into the mold. Spread garlic puree and drizzle the reduced juice. Cover with plastic wrap in contact, top with another mold and some weights and cool to room temp and chill for a few hours or overnight to set completely.
Flatten cheese between 2 lightly oiled parchment paper into a disk (mold diameter). Remove top plastic wrap from the chilled endive tatin. Add the flatten cheese and enclose the pie with the baked crust. Endive tart tatin can be stored in the refrigerator for up to 3 days. Unmold and reheat the tart in the oven for about 10 min or microwave for a couple of minutes or until the cheese begins to melt. Slice out and enjoy!
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Posted on 12/12/2019 at 09:02 AM


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Earn points toward FREE PIZZA with Piece of the Pie Rewards
More About Domino's Near Rome
Spicy, Sweet or Savory: Order Pizza Near Rome
When your tastebuds are tingling for a delicious slice of cheesy, meat-topped goodness, we know you're not craving any old pizza near Rome. You want a delicious pizza with a robust tomato sauce, perfectly sliced chunks of pepperoni, generous piles of mozzarella and parmesan, and a golden-brown crust that's both crispy and chewy. You want only the best pizza. You want Domino's.
At Domino's near Rome, we make it quick and simple to get the fast, fresh pizza your hunger craves. Place a carryout order at the Domino's nearest you, order your pizza online, or give us a call!
Get started by picking one of our homemade crusts, including a fluffy, garlic-seasoned hand-tossed crust, a pan crust featuring two colossal layers of cheese, a crunchy thin crust, or even a gluten-free pizza crust! Next, pick your sauce and load up on your favorite, most delish pizza toppings. Whether you're all about the veggies like green peppers, spinach, and onions, or you prefer the sweet and savory combination of ham and pineapple, your pizza dreams can come true at your nearest Domino's.
There are over 34 million ways to craft a single Domino's pizza. That means you can be sure we've got a slice for whatever your hunger demands! From its sauce to its size, build your own pizza or choose from one of our famous specialty pizzas, like the ever popular Ultimate Pepperoni, MeatZZa™, or Cali Chicken Bacon Ranch, and have it delivered hot and fresh to your doorstep, today!
Pizza Delivery Near Rome: Deliciousness at Your Door
When it comes to pizza delivery, we take things pretty seriously at your local Domino's near Rome. In fact, we promise your pizza will arrive hot and fresh at your door, right out of our oven. Want to stay up to date on your order? Our delivery experts specifically engineered the Domino's TrackerⓇ to do just that. Enter in your phone number online and track the status of your order from the moment it's placed to the second it leaves our store for delivery... and in the meantime, do your best not to drool on your computer or phone.
A Recipe for Success: Pizza Takeout Near Rome
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To what aspects of "this . . . system" are you referring? Or were you just venting, which is OK but often confusing.
I just explained that in the previous sentence. What is your purpose here if all you can do is dissect our opinions and throw out your defense of the "screwed up system". There, figure it out again.
Do you mean Eccles book "How the Self Controls its Brain"? I actually have a small connection to Eccles in that area - as he often quoted, and was in frequent contact, with Benjamin Libet who I worked with in designing and analyzing some influential studies he conducted on the subconscious mind in the 70s and 80s.
"We have no end of solutions to crises, but systemic change is required to overcome the short-sighted greed that sent us speeding down this path," so said David Suzuki. End solutions to human crisis events are possible, but there is an end which looks less luxurious thankfully hopefully an end to crude wastefulness and opulent disregard for environmental impact and resilience.
Good interview (imo)
Why it's time to think about human extinction | Dr David Suzuki
"Can the damage we've done to the planet be reversed? Is extinction of the human race imminent? We talk about population control, the importance of renewable energy and discuss what we can do right now in our own lives that can actually make a difference.
This is for anyone who cares about the future of mankind.
Why humanity has only got 1 minute left to live
Humans are the only species that don't care about their own children
Educate yourself on politics or don't complain about the government
Can we be saved from our own extinction?
A final challenge for entrepreneurs
Oh–OK. Clearly, venting.
Q: Where on earth do you get the idea that I am DEFENDING any particle of whatever "system" you have in mind?
There is only one possible solution to humanitys on going demise .
It's a spiritual solution,understanding our Oneness with each other and that everything is connected …from there the solutions will appear from no-where to now-here the dominos will be set in motion.We will suddenly begin to see what we must do to make our planet work for the highest good of all not just for the interests of the rich and powerful .
We will all want it this way .
All For One And One For All.
The Golden rule will finally be practised not just a fleeting statement .
We have tried & seen FAIL miserably:
"Trickle down economics" ~ total failure!
Deregulation of banks & businesses. Fail!
Propping up oil & gas, while NOT doing same for "alternative energies".
Private, for profit health care/ insurance. (How did they help us with pandemic?) Fail!
Massive (grotesque!) funding of Defense Dept. that is NOT about defense. It is a "War & Killing Dept." Pure & simple!
We have bailed out those "too big to fail" & they didn't change.
Let them fail!
Business mergers ~ Let markets decide. Fail!
Campaign funding "reform" ~ FAIL! (Electoral College is also a big fail!)
Tax cuts for the very wealthy… Epic fail!
Positive changes from top, down. Fail!
Seems to me that changes, new ideas, tolerance, saving evironment & climate change…& definitely, consumer economics & real wage growth – must come from the bottom, up!
Grassroots, not status quo, is where change for thr better comes from!
The Establishment does not "change course" unless forced to do so. And most often, not until too late. We don't have the luxury of time to wait for them to catch up. It is up to us all!
No disagreement with everything you wrote.
But my question is, of course, so what is he, and we SUPPOSED to do? In actual reality… not in some social/eco warrior fantasy novel?
I am at a loss. Spouse and I have spent our entire adult lives, working fairly society enhancing jobs, trying to raise two good kids, living a modest life and spending a fair portion of our time trying to support progressive local candidates with our time and money, trying to educate family, friends and community on the important issues facing the country and the planet, protesting, calling writing and all the rest.
I certainly do not think our little efforts of one family would or should change anything but I see lots of people doing what we are doing and yet the needle has , if we face pure unadulterated reality, moved to things getting exponentially worse… A few bright lights flash occasionally but nothing holds and rebound seems worse than before the bit of light…
What can anyone seemingly do including Suzuki?
Get a few monuments torn down, a few flags changed, a few kids out of detention while in a week triple that amount maybe locked up, an environmental law changes for the better whilst ten more awful things are done in the same day…
We keep trying to move forward and stay involved in the fight to do better but more and more the doom is just enveloping us and sapping our energy. Spouse and I are realizing we are, aided by the pandemic now, just starting to retreat , if you will, into our little zone conserving our energies now just for the survival of our little circle of home and family/good friends …
I see many public activists like Suzuki somewhere on this spectrum. Eventually the teaching and preaching and educating by him and others is realized to be falling on deaf ears… as we spiral ever downward…
What a thoughtful reply – thanks so much!!!
Lately I find myself in the unaccustomed position of being the optimist in the room, for once – but only because it's becoming increasingly obvious we need to start over again, "organizing its powers in such form" as the old slave-flesh merchant wrote. And the actual room is a small one to be the optimist in. I don't have a more exalted political guru in my life than Sister Angela, who says she never thought she'd live to see this day. That has me convinced: We're watching and working with something real.
My impatience with Suzuki is simple: Name the oppressors, if you care, because these public-pirate academic partnerships that putative enviros like McK are corrupted with haven't gotten us anywhere, have they? It's rude to suggest the possibility of casual, look-the-other-way corruption suffusing beloved institutions like the ivy-covered walls of privileged academia, but look at the mess, really: professors for sale all over the place. In that context, and with the suspicious presence of WWF plugs to boot, I have an idea why Suzuki doesn't mention enemies: for the same reason McK doesn't: because he's sold out to them, he's neck-deep in public-pirate partnerships, building better tomorrows.
In that context, if that's what he's doing, it's not complicated to suggest that he might stop it, that if he weren't working with predatory organizations like WWF he wouldn't have so much trouble speaking certain essential truths: such as who's been doing this to us. My question to Suzuki boils down to "Which side are you on?" Essays like this one are counter-productively ambiguous, imho.
You posit a deeper question about what people should do in general. I can only answer for myself. I've had very heavy disorientation in my life, and gotten in the habit of flailing for solid foot- and hand-holds as I scrabble along. There are always limitless intervening priorities, but my devotional exercise – for which some time each day must be reserved – is understanding this point in history, taking in what I can about my temporal reality, here in Richmond, CA. If they haven't yet entirely paved over "Albany Hill" where I used to walk, there were profoundly timeless grinding bowls for acorns worn into serpentine outcrops there. Staring into that contact with original inhabitants, and feeling the connection to today, that's where I want to be – though I'm not sure what I mean to do when I get there.
Upon reflection on your words I see what you are saying about Suzuki and Co. and it was eye opening. You have altered the lens with which I will be looking at these people going forward.
As well as your quite profound thoughts about placing your thoughts about yourself and your place as part of the timestream to gain perspective and optimism . Sorry if my interpretation of what I hear you saying sounds goofy- I don't seem to have the facility with words I did in my youth but I think I do get it. And will be trying to find that kind of perspective .
Thanks Aleph, I always find your thoughts valuable.
Here is something that I learned from this and that is how things have changed. I think it most telling when serpentine changed from a simple tool to an indication it is commonly found in an area that produces gold, to a state rock, and then a misunderstood mineral. There is a lesson here.
Edited: I should have included your source as a touch stone…a nice touch.
Very funny, fern. That brought a chuckle.
I really like rocks, they all have a history, I have a large chrysoprase (a relative of serpentine) that is like an old friend. I have to be reminded they have amusement too. Thanks
That's very interesting about Libet, thank you.
I am such an idiot today with malapropisms, I screwed up the title in question:
The Self and Its Brain: An Argument for Interactionism (with Sir John C. Eccles), 1977
I remembered Mind for Self, because that's really the intersection of Popper and Eccles' dialectic: pretty close to the physical barrier between the self-hood of a cognitive mind and the dance of chemically or electrically excited nerve cells. My lockdown partner quibbles with overuse of the modifier "literally" – this philosophical slash neurophysical moon-dive of a book is almost literally mind-blowing, imho.
The two of them, Sir Karl and Sir Jack, diverge quite a bit on basic philosophical questions. Unexpectedly, Karl Popper strikes me as the more scrupulously scientific, not as beguiled by humanistic hunches as Jack Eccles. I guess it seems ironic to me because Eccles is more intimate with impenetrable neurological mysteries, but less epistemically awed by such mysteries than Popper.
What are we supposed to do? There may be a means for redirecting industrial manufacture away from those which require long-distance travel and transport of material goods and finished products. The global economy must begin to phase down to be replaced with local and regional economies supported by state and national economies. The most important scales of economy are local and (metropolitan area) regional because they must address insane traffic which will only be made worse with "driverless" car nonsense. GM's new ads predicting "Zero accidents and Zero traffic congestion" is pure deceitful marketing. Daimler Truck wants us to believe their electric model rig isn't a colossal waste of battery resources. These corporations can be taken to court, but just proving their schemes are absurd would be enough an embarrassment to get their attention. We may need to "nationalize" the railroads to build operable reliable Amtrak service. If Warren Buffet doesn't like it, tough. His BNSF RR is the king of Coal/Oil/Gas shipment. He owes us.
You missed my mention of 'realistically' . Good ideas though of course. They just won't happen without a collapse or revolution.
Our transportation systems are a core problem that if addressed first are like dominos tipping the rest. If we couldn't drive nor fly, nor truck and ship goods around the as much as we do, things would change and we'd lose undue influence of corporate business interests. There must be some legal means to hold big industries accountable for their failures and responsible to manufacture vehicles whose designs aren't based on Planned Obsolescence. They're certainly lying about "driverless" car nonsense.
No argument there.


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He found Lios examining the newly healed skin on his torso, which still looked pink, and a bit angry. The young man looked up at his entrance, and hastily started donning the clothing piled on the gurney next to him.
"Wait a tick! If you don't mind, I'd like to have a look."
Lios was not yet ready for company.
Ideally, he'd have liked a day on his own, rather than the precious few hours he'd had to process the current state of his life. Plenty of experiences needed compartmentalisation, and he needed to wade through more than his share of revelations regarding his values and priorities.
It was more than just the girl. It was more than the adventure, or the terrible turn it had taken toward its end. It was everything. Adventures were wonderful, necessary, and he knew being with the Doctor meant some of their expeditions would be hard. They would be full of danger. They would be pivotal for the growth and prosperity of the places they saved… or damned with their interventions… and that was always hard, but it was eye opening, nonetheless.
And then there was his sister. He'd thought about their predicament, and her reticence more than a little over the last two weeks. He'd been at a loss as to how to go about bridging the gulf between the Doctor and Selene. Watching how well they worked collectively, feeling the synergy, the extreme rightness of it all as the four of them came together could not have been coincidence. It was right. But he didn't know how to keep it from falling to pieces around his ears. Where was the glue which would keep his family together? How was he ever going to find it, and how could he make them all understand how important it was? Further, he'd sensed his sister's timeline, and that shouldn't have happened. Sure, it was weak, but he'd never even glimpsed it before. Despite how well they'd come together, despite the comradery the Doctor and the Alpha had struck, he was terrified they were ultimately going to lose her. He'd been so sure – it had been so easy to come away with the old man and believe it would be their saving grace – but he was no longer so confident it had been the right move on his part. Perhaps he should have been more cautious. Perhaps, he had mucked everything up already, and nothing could be saved.
In short, he just wasn't ready to face the Doctor and keep his emotions in cheque.
"I'm fine. All healed," he replied as he buttoned his trousers, not looking at the Doctor.
"Have you ever used a dermal generator before?"
"No, but I figured it out."
"Let me have a look then."
"It's fine, honestly."
"Why does everyone assume I'm the Doctor in name only?" the Doctor groused, all indignant pout and flapping hands. "It's like telling people not to wander off. They never listen when I say, 'I'm a doctor.' I am a doctor, Lios, or, well, no… not of medicine per se… I've got degrees! Honorary degrees! But with as much as I've seen and done, I am as qualified as any MD, and I'd like the peace of mind a proper examination will give," he said, taking the younger man by the arm and guiding him onto the gurney. "Last thing either of us needs is your sister going mental because you became septic when I could've prevented it."
Lios shifted uncomfortably for a moment, then seemed to come to some internal resolution, and shrugged, lying back.
He appeared to have done a decent job of repairing the wounds on his torso, but the areas harder to reach were left only half healed.
The Doctor retrieved the instrument, and set about finishing them off.
"It'll heal itself in a few days…" the young man mumbled half-heartsedly.
The Doctor ignored him and continued his ministrations. He had finished the right shoulder and arm after a few minutes of strained silence, then made his way to the other side of the bed. If he'd let the silence stand, perhaps the eddies and ripples in time would have moved in another direction.
Harbingers of misfortune rarely wear neon signs proclaiming one's fate. They do not come dressed in mauve sequined disco jumpsuits – unless of course they're from Bendragonas III, where the standard uniform of the palace guards in the Northern Sector were just such eye-offending spectacles. Most disasters of fortune begin with an innocent query from a concerned party, such as "What's that shadow," and "Why is it getting so big." Sometimes, if the concerned citizen asking has the time, or indeed is too stupid to run, this is also followed by "Why is it on fire." The Doctor's particular point of inquiry, while not in reference to a planet killing event, was intended to earn a smile, and, perhaps, win a little trust, but it heralded much more, just the same.
"So, Heliosdanaritaxicor," he tried with a tight smile, "tell me about the nymph."
Lios went very red all the way to the tips of his ears, and seemed to want to evaporate. In fact, he was checking to see if he had the ability, though without finding much success. "Nothing to tell," he spluttered. "I… I let her pretty face cloud my judgement. Won't happen again."
He just wasn't ready to talk, and the pushing would either shut him down completely, or make him spill his guts entirely. Lios wasn't certain which he preferred.
While the Doctor had an easy time reading these things on his hot-tempered sister, Lios was less transparent. Lios smiled in the right places, kept his temper, and was not talkative as a rule. The young man was generally gentle, so the Doctor had no idea he was pushing too hard.
"Ah, but where is the fun in that? It's all over, isn't it? No harm done on your part, and what an…"
The Doctor had fixed his eyes on the mysterious markings on the young man's arm, which might have been mere decoration and nothing at all to worry over, but life was rarely so kind. The Doctor had never seen this particular phrase casually. No, it always came with all the weight of time and impending calamity. His face was inscrutable, but the torrents behind his green eyes were not lost on the observant young man.
Lios knew it had been coming, and perhaps, welcomed the release the inevitable blow-up would provide, so he waited for the older man's reaction.
For his part, the Doctor felt like his hearts had stopped. Seeing anything about Bad Wolf written in Gallifreyan was jarring, and sent him reeling. They might be no more than tattoos… given who this young man was, it might have been a tribute of misguided reverence, but again, he doubted it. Rose would not have let them cling to such naiveté. Yet, the Doctor was not willing to jump to any conclusions, especially conclusions which may well presage trouble for Rose's children. He hoped he wasn't making a mistake.
"…an adventure," the Doctor continued, his face becoming a mask of frivolity. "Sorry," he cleared his throat. "Thought I might have left the kettle on for a moment. I haven't. I haven't been near the galley in hours. Tea does sound lovely though, doesn't it? Anyway, yes, quite the adventure. Your brother is quite angry with your sister, though. Might need a little intervening. That's your specialty isn't it? Forgive me for assuming it, but you are better with both of them than anyone gives you credit for. I'd offer, but I think reason and pragmatism isn't what Torin needs right now. Perhaps, you should go find him when we're all done here."
He went back to his task with a blithe, I'm-the-Mad-Man-with-a-Box-and-Nothing-Bothers-Me smile, which didn't quite reach his ancient green eyes.
"You're not going to say anything?" Lios snapped with not a little frustrated disappointment. He wanted to row— needed the row at that point. He felt like everything – all the hiding, all the secrets, all the running after his sister and being shut down constantly, and mediating everyone all the time – was crushing him. He needed the weight gone from his shoulders, and it would be thrown at the Doctor's feet if need be.
"No, I rather think Selene has the right of it," the Doctor hedged, "but that's because I'm very pragmatic myself. You see, Torin is upset that—"
"That's not what I meant!" Lios bellowed.
"Oh?" The Doctor sighed, looking very old, and very tired as he regarded the stormy blue eyes piercing into him. "You'd tell me if I asked? Your sister hasn't forbidden it? It's the reason you didn't want my help, obviously. Getting you lot to open up has proven exceedingly difficult so far."
The wind abruptly left the young man's sails. His posture collapsed down into itself, and he slumped forward with his head in his hands.
"Selene is scared you'll chuck us out," Lios murmured hoarsely.
The Doctor furrowed his brows, what kind of monster did she believe he was?
Was he really that bad?
Maybe he was.
The road hadn't exactly been a smooth one with her, and, perhaps, he might have overreacted at first… but no! No, he felt absolutely stung by this unfair belief she harboured. How very incredibly little she trusted him. He wasn't a tyrant. All he'd done was try to help. They'd argued, but it was no reason to believe him capable of purposely doing them harm. And for this? It was ridiculous!
"Lios Tyler, I know where you come from. Why should this be so shocking?" he demanded softly, trying very hard to keep the accusation from his voice. "And why would I ever chuck you out? That's a bit insulting, really."
"I know she doesn't trust me – well, I thought we were making progress, but, that is only very recently, and to be honest, I suppose I don't blame her. She's been scared – terrified really – and I know how important you are to her, and I'm… I've… I'm…"
"Doctor, she—"
"No, it's alright, actually. Were I her, I would probably do the same, honestly, and I just have to learn to forgive that quality in her."
"Doctor, she's—"
"Really, you don't have to try to make peace between us. I'm not angry. Er— well, not very angry—I-I'll get over it. I won't even mention it to her, if that's easier for you. I can't imagine she would be happy I've found out before she bestowed the honour upon me herself. Am I right? This is what happened when you looked into the Untempered Schism, isn't it?"
"Yes, but Doctor—"
"You all have them then? Same place?" He sighed, "I wish I'd taken more time to understand this Bad Wolf business. Just when I think some strange chapter in my life has finished, it comes right back. Of course, it is hard to leave behind something which was scattered through space and time specifically to follow you. I'm sorry I caused this, Lios. I really am."
"Doctor! It isn't your fault! Please! Don't start that."
"You're a good man, Heliosdanaritaxicor, but yes, it is. Any way you trace what happened with Bad Wolf and your mother, I'm at the root of it, aren't I? I'm not saying I regret having you here, but if I'd never meddled in your mum's life, this wouldn't be happening. Have you lot figured out why it's there then? Are you willing to share with an old man?"
"No, we haven't, not exactly, not fully, no matter what the Alpha thinks, and I'm gonna bloody murder Torin for spilling that name to you. But Doct—"
"Ah, but it's Selenialatovara Tyler you'll be murdering, not Torin Tyler, whose short but brilliant name is apparently an homage to Tyler-kind everywhere." The Doctor smiled warmly at him, and gestured toward his arm for permission to examine it more closely.
Lios nodded, and opened his mouth to speak, then snapped it shut and drew his blonde brows together. He held his arm out, letting his internal debate rage wildly once again.
"Lios?" the old man hesitated. "I'm going to do something right now that I almost never do – on principle, you see. Well, while I say almost never, I really can't recall the last time I did, but that's hardly surprising. I am very old, and very stubborn."
The Doctor traced the golden writing with a finger for a moment, then scanned it with his screwdriver. Plenty of tests were viable options – and he'd run them all – but the basics were always a good place to start.
"Where was I?" he asked after examining the readouts on his sonic. "Oh, yes! I'm going to ask you for advice. You're cautious, and I'm… not. Well, no, I am, very extremely cautious about some things, but I've cocked up enough so far so… er… I mean, I'm in considerably new territory here after all, and the last thing I want is to undo the headway I've made with your sister. She told me she likes me—er—no, she didn't, not really, but she said we could be mates, and you like your mates, right?" He smiled a little bitterly, and tried to catch his patient's eye, but Lios was staring firmly at the marking that could have been a tattoo, but undeniably wasn't, and refusing to make eye contact, "But, well," the Doctor continued hopefully, "you know her, and honestly seem to… handle her better than anyone. Not that she needs handling. What I mean is, you understand her, and she lets you take care of her more than she lets anyone else."
Lios still would not look at him, but his words seemed to make the boy crumble behind his stormy blues.
"Should I confront her?" the Doctor carefully posed, understanding finally what a vulnerable state the young man was in. "How… how serious is this? What can you tell me? Would you rather I just had it out with her, and left you out of the middle? Is it better to let it go? All I want is to make sure you're all protected, Selene included. I'm… I'm at a bit of a loss, you see. I'm tired of fighting with her, and she always seems to be able to avoid whatever she doesn't want to share anyway. She's very frustrating."
"Selene…" he half whispered, "Doctor, she's my sister. She's…"
"Yes! No, I know! And I understand if you'd rather not get involved. I'll just leave it then."
"No!" he yelped, his voice returning in force. "Doctor— She's— Doctor, I love my sister and I want to keep her safe. She's – I can't – But she's – God! She's so stubborn – and infuriating!"
"Well, yes, just said so myself, didn't I? In fact, I think I expressed all those things."
"She won't let anyone help her, and she's so goddamn self-righteous that she probably never will!"
"Well, I—"
"But she's my sister! My only sister! My big sister, and my protector! She's part of what makes me whole, do you understand? Sh-She's taken care of us and sacrificed so much so that we wouldn't have to! She's dedicated and loyal! She's a good person, Doctor! She is! She doesn't deserve… this…"
He tore at his pointy blonde hair and let out a gruff cry of frustration.
"Alright! Alright! I'll back off! I won't say a word to—"
"No! This life, I mean, or me utterly betraying her right now—"
"Hold on a minute! Don't beat yourself up! No one is betraying anyone, Lios."
"—but, you—someone has to say something! Someone has to help her! Please! She's my sister! Promise me that you'll help her?"
He grabbed the Doctor's tweed coat and clutched at it like a lifeline.
"I-I'll do whatever I can, you know I'll—"
"Promise me," he shook the old man in his grip slightly, "promise me you won't get angry with her, or refuse once she's blown her top, 'cos she will! Oh, God! She will! She's not even going to speak to me for…"
The Doctor put his hands over Li's and gently eased his vise-grip from his coat. Lios looked down at his hands before dropping his head into them.
"…well, if you can help her, it'll be worth it." His voice was muffled between his fingers, but the agony was crystal. "There's always a price isn't there? A price for what's right. If the price for her life is my betrayal, then I have to pay it, don't I? Torin doesn't understand, but I do! I can't ignore it all because I prefer things cosy."
"Alright, keep calm!" the Doctor placated, resting a hand on the boy's shoulder. "Back up a bit. What am I missing? Why doesn't she want help? What do you mean?"
He raised his head from his hands and met the Doctor's eyes with determination. "The markings. It's not Bad Wolf, Doctor. Selene is co—"
"Wha' now? I'm wha?"
She stood in the doorway with her face a mask of calm and ease, but Lios looked horror-stricken and his words died in his throat.
"Omega, wha' were you sayin'? The Doctor's waitin'."
The Doctor observed as the two siblings stared at each other in the tense silence, the Alpha challenging, and the Omega pleading, but not lowering his gaze.
He decided it was up to him. "Alpha," he began in order to keep from further antagonising her, "would you mind showing me your arm? I wish you'd have told me about this, but I'm not angry with you."
He took a single step in her direction, but halted when she mirrored his step forward with a step back.
He put up his hands and moved back again.
"I knew you were keeping something from me, and honestly, I thought you'd give me a little more credit than this. I knew you lot were closely tied to Bad Wolf. You have nothing to worry about from me."
She continued her unblinking showdown with Lios, all but ignoring the Doctor and his assurances.
"It wasn't Li's fault, you know. I came in and saw before he was finished. He tried to keep your secret, but we have no need for these secrets between us any longer. Please," he pleaded, hoping against all odds for peace and resolution between them, "let's just move forward from here. May I see your arm?"
She finally looked away from Lios to let her eyes bore into the Doctor's.
Hard and cold as ice, all fire absent, she was being exceptionally hard to read. She wasn't displaying any of her usual signs of agitation, like fidgeting from foot to foot, nor was she faffing about with her layers of clothing. No exasperated huff escaped her lips, and for once, her brows stayed smooth and separated.
She looked less like a huffy know-it-all, and more like a woman who had lived over a century. Her eyes expressed utter weariness, resolve, and sadness with a hint of regret.
"Las' bit's in," she said finally, but didn't take her eyes away from his. "I'm gonna try to power her up with the little channeller. Thought maybe we'd do it together, but maybe 's not such a good idea after all. Li still looks like he could do with a bit of help. I'll jus' be headin' back."
They were both startled from their silent disagreement by the clattering of metal on the floor.
Lios had jumped off the gurney, knocking the dermal generator off its cart, and was advancing on his sister with helpless frustration clearly written all over him.
He reached out and seized her muffler as she stepped back toward the corridor.
She had a stern warning on her face, and he, a desperate apology.
The bare-footed young man, in only a hospital gown and trousers, moved closer, and obscured her from the Doctor's view.
"Little Brother, please," she begged through gritted teeth.
Though he couldn't see her, the Doctor could hear her torment, and moved forward to intervene. Surely, they all could work through this without so much agony?
Amber eyes locked with blue. Love filled both, and for a fraction of a moment, the air cleared, and brother and sister were united once more.
Then the Omega's face hardened, and he tugged.
The red bit of fabric fell away, but by the time it hit the floor, she had taken off, with speed and silence, back the way she'd come.
Lios hung his head in shame as he stifled a sob. He bent to pick up the discarded length of red, then stared at the pathetic wisp of ownerless cloth in his hands.
"She's got them everywhere," he whispered sadly. "The words. It's not just her arm. She keeps covered, but they come almost all the way to her chin. Torin… Torin and I… it's on our arms, and just about the Bad Wolf… Not her… Hers are… so much worse… She's… Doctor, please… please, help her…"
He stood in the doorway, holding the limp scarf, tears streaming down his cheeks, and had never felt so ashamed and alone.
"I don't want my sister to die, Doctor. Nothing is worth that," he croaked. "Not some planet or… anyone, I don't care how that sounds."
The Doctor, too, felt frozen in place. He'd been there for two rather major fights between brother and sister, and hadn't a clue how to fix any of it. Normally, he'd suggest they go for a trip, and hope it worked itself out, but he had an inkling the root of the issue was much deeper than a few hurt feelings. He was still foggy on exactly what had happened and why. Lios was pleading for Selene's very life, and it made no sense at all.
"Please," he implored again. "She's not a pawn for the universe to play games with. She's my sister… my sister…" Lios swallowed the hard lump in his throat but couldn't look up from his toes.
The Doctor finally unglued himself from the spot where he'd stopped transfixed, and moved to take Lios by the shoulders. He waited until the young man could finally look him in the face before speaking.
"Have you seen them all?"
Again, Lios found the floor irresistible to look away from.
"No. Yes. Not exactly. I've seen them all written down, but they're so hard to decipher. They could mean so many things… Please…"
"I'm not going to let anything happen to your sister, calm down." He pulled the boy in for a desperately needed hug, then moved back to try catching his eyes again. "Tell me what you know, and what you think you know. Tell me everything. Big things, little things. Things you don't think I'll find important. I need it all."
The TARDIS prodded him to get his attention, but he studiously ignored it as he focused on the youngest of the children.
"I will. Please, give her one more chance though?" He finally looked up at the Doctor. "To tell you herself, I mean. She's got them all written down, and maybe she'll even give that to you. If not, I'll get them, but, please, it's important that it's on her terms as much as possible now. I'm afraid—I-I'm so afraid she's going to do something stupid. Maybe if you… Maybe if she sees you're on her side…"
The Doctor shook his head and smiled sadly. "She won't tell me anything, you saw how she looked at me, but I'll make the effort—er… Should I go alone?"
Lios seemed to shrink to half his considerable size. "She won't want to see me for a while. She's really upset. I mean, really upset. She's shut down our telepathic connection and everything."
The Doctor reached out for her presence himself, and found nothing. The girl was barring everyone. Not exactly hopeful.
"Understood. Hey," he stopped on his way out and put a hand on the young man's shoulder.
The look in his eyes spoke of guilt, panic, and immense pain. He pulled the boy in for another hug and found himself being clutched like a life-preserver.
"Deep breaths," he soothed. "It's gonna be alright. Really, it is. At least the secret is out, right? That's always the worst of it. Like ripping off the duct tape when you've been captured, right? It's terrible, and you want to scream, and maybe leave explosives in their basement, but it gets better. Now we can sort this mess out, alright? You did what you had to do. Maybe it doesn't seem like the right thing right now, but sometimes the right choices feel wrong, or too hard to make. I was just talking to your sister about that, actually."
"When we do this to each other it hurts, physically and everything," he confessed pointing to his head as he pulled away from the hug. "For her too, and she's doing it anyway. She's punishing us both. It's just… if we lost her for real… I'm such a prat. I just should've tried harder with her."
"Oi," the Doctor interjected firmly. "None of that, Lios Tyler, she's going to forgive you. She'll have a fantastic shout at me, we are overdue after all, and I'll make sure she gets it all out. Leave it to the Doctor, eh?"
The ship gave him another impatient prod that he pushed aside. He was going already!
"Doctor… I… I am…I can't… Thank you."
He nodded benevolently, and set off for the young TT capsule in which he was sure to find the Alpha hiding out.
Hopefully, he'd be able to get back in.
He had a feeling, even if she had locked it, he would no longer be denied access by Torin or Lios.
After a few minutes of meandering slowly to gather his thoughts, the TARDIS moved the console room just to the end of the hall. That was helpful, and he thanked her silently, even if she was nagging him to hurry up as he plodded and mulled over how to approach the surly woman, who hated to be less than perfect and right, but admitted talking it out wasn't her forte.
Only, when he arrived in the console room, the TARDIS that had been pretending to be a tree was conspicuously absent.
The Doctor rolled his eyes.
She must have fixed its cloaking device.
He wasn't going to let her childish antics affect him, however. He was going to be the essence of patience and wisdom. Zen. He was Zen, and she was a motorcycle in need of maintenance – but that book was rubbish. He'd forget that analogy. He was going to break through to her, and fix everything because, as she had pointed out the day before, he was the madman in a blue box who did just that.
Fixed things.
And, if he could bring down corrupt empires and peace to solar systems, what was a bit of cryptic writing and a domestic between his kids?
Er—Rose's children.
Mates of his, really. His mates.
She wanted to be his mate, right? Here was his chance.
He strode over to the corner where he knew it to be, and reached out to feel for the knot where he'd find the door, but met only air and nothing.
Panic swept through him for a moment as he continued moving forward. He should have smacked into solid timeship, and there was nothing.
He dashed from empty space to empty space in the hollow hope that he'd only misremembered its location, or that she'd moved it somewhere else to throw him off.
After three minutes and thirty seconds, he gave up and ran to the console.
"She's really gone, hasn't she? How? It shouldn't— I took the bloody thing! Oh, Rassilon, Old Girl! What in the bloody hell is she thinking? Show me!"
The TARDIS sent him a wave of her own frustration and sadness, and the images of the Alpha running into the console room chased by Jack.
The captain stopped her, and pulled her in for a crushing hug. She wriggled out of his embrace, and started to make her way to her ship. Jack grabbed her hand, spinning her back around. They seemed to be shouting at each other, then stared for a tense moment until the captain hung his head, and followed her inside. Nothing more happened for another few minutes, then the tree began to disappear.
Not fifteen seconds after it had gone completely, he saw himself pensively enter the room before the memory faded.
"She's left."
He was utterly bewildered.
"No word to any of us. She just left."
How could things have gone so entirely wrong in so short a time? Why did it feel like he was smack in the middle of the mother of all tantrums, and what wouldn't he give for a way to send everyone to their rooms for a century?
"Who does that? Who the hell does she think she is? Where did she go?"
A set of coordinates appeared on the monitor. Cardiff. He sighed in relief. Unless she was dropping Jack off before running off, she probably went to refuel. It also meant that she probably wasn't leaving there in a hurry.
Grounded. She was bloody grounded. Maybe, he could put her in the zero room for a time out while he worked on a way to lock her out of her ship. He'd leave her on Earth for a while, but he couldn't put the humans through that.
Should he go after her while she was stuck?
As if the very act of thinking it was enough to chase her away, he lost her coordinates the next moment.
"No!" he yelled, and began combing for any sign of her TARDIS. "No, no, no, don't do this!"
The search could take hours.
Oh, Selene Tyler. What are you doing?
The timeship sent a feeling of loss and grief, then the image of Lios pacing in the infirmary. This was followed by Torin in the darkened library, brooding with his head in his hands. She sent him a feeling of grief again, and the equivalent of a mental push.
"We'll figure it out," he said calmly, as much for his own benefit as anything. "It's not the first time she's run off in anger. She'll come back. She just needs to cool down. We'll stay here a bit and give her a chance to do. She'll come back, Sexy. She's young and hot-headed, but she'll come back."
The ship sent the images of the boys again, and pushed.
"Yes, I suppose I'd better, but shouldn't we give it a bit first? Just in case? No sense in causing them any more worry."
Impatience and a push.
He sighed, and ran his fingers through his fringe.
But which to start with?
Torin might rage and pretend he was glad she'd left, whereas Lios would likely blame himself entirely. Neither prospect was appealing. Blimey, he didn't like playing the mediator. Selene Tyler would be grounded to the zero room until – well, until he decided it was long enough, and Jack… Jack was lucky their timelines were out of sync and the paradoxes his death would cause were major. He'd find a way to make him stay dead otherwise.
He hesitated, glued to the spot in front of the corridor while he weighed which young man would be most upset.
The TARDIS gave an impatient hum, and it was only a few minutes before Torin's curly brown head appeared around a corner, followed very quickly by Lios's spiky blonde around another. They exchanged looks of concern for each other before looking toward the Doctor.
Thank you. He growled mentally at the Old Girl. Thank you so very much. Could have given me just a few moments, couldn't you? But you just take all matters pertaining to them into your own hands, don't you? Interfering box of bolts with delusions of being a nan.
She sent him a mental huff, then went back to wallowing in her own upset.
Oh, how was he going to do this?
"Your sister scarpered," he blurted.
Brilliant. Very well done indeed. Still, to the point, in any case.
Both young men stopped in their tracks with matching stunned expressions.
Torin's face quickly melted into a look of annoyance and anger, while his brother's morphed into utter terror and panic. They silently regained themselves, and hurried into the console room to view the offending empty space.
Torin was the first to speak, "I'm so bloody tired of her right now, I can't even find the words." He tugged at an ear and pinched the bridge of his nose. "Me. I can't find the words."
"Shut the hell up, Torin!" Lios exploded, rounding on his sibling with naked panic in his eyes. "You don't know the half of it."
"Oi! Watch it!" Torin retorted back, the uncharacteristic outburst catching him off guard. "You said yourself she's been bang out-of-order lately! Now she's swanned off in our ship without even a word! And what?" He advanced on Lios, and threw his gangling arms in the air. "We just wait until she feels like coming home? Since when are any of us so far beneath her that we should put up with that kind of bullshite, eh? It's not right, and she can't be doing this!"
"Torin, she isn't coming back!"
Torin shoved his younger brother and yelled into his face, "Shut your bleeding gob! 'Course she is, you prat! The Alpha wouldn't do that! Just shut the hell up!"
"Torin," Lios shouted, and lunged forward, catching his brother by the lapels of the new blue suit the TARDIS had provided.
The Doctor moved to pry them apart, but Torin held up a hand. Lios was staring into his older brother's eyes and pleading as he mentally flung the the incident in the infirmary at him.
After a few tense moments, the two melted into matching postures of defeat.
"She wouldn't just ditch us, Li," Torin insisted in a whisper. "She wouldn't."
Lios looked broken and lost, but convinced he was right.
"Torin… Brother, I could see her timelines. That should never have happened, but I saw them, Torin, a little bit on Olympia, and just then in the med bay, they were clear as day, and I've… I've had this feeling… for months, Torin, months… She was always going to leave us… It's why I… pushed."
"I agree with Torin," the Doctor interjected. "I think she's just blowing off steam. She's totally lost without you two. Try to relax. We'll sort this. It's a steaming mess right now, granted, but we'll sort it. We'll wait. She'll be back."
He tried to sound confident, but, as the two debated, he was losing conviction.
When he put himself in Selene's position, it was hard to ignore that she'd left the two for whom she cared most in relative health and safety, and with a sort of guardian. She'd taken Jack – not gone off alone – and stopped in Cardiff where she could refuel. Lios had made it clear that she was either in, or intending to be in some sort of danger. Perhaps she was trying to be noble.
"I need you to tell me what happened at the Schism. Really tell me. I need to understand why she would do this."
Neither looked at him, but they both nodded.
The Doctor felt the invitation to accept their memories and allowed them to wash over him and coalesce into one, if slightly manic, set. They were all tinged in grief, anxiety, and determination.
And love.
So much love.
They had looked into all of time and space… and it was… terrifying… and heartsrendingly beautiful…
…..and intoxicating in its power, but unbelievably overwhelming, and seemingly uncontrollable – which was new to be honest, and not a little dismaying – and it was… it was…
…looking into them.
They were looking into all of time and space, and all of time and space was looking back – searching for something.
Did they mention how overwhelming it was?
Bright light completely blinded their vision, and no matter how they tried, they couldn't move.
Selene was gone – and not.
Her little blonde head was there one instant, and gone the next, but they could feel her hands grasped in theirs, despite the void between them…
…which made no sense in the sensory sense, because the senses usually agree when you're very clever and not easily surprised, but who were they to argue with All of Time and Space if making sense didn't seem to matter very much to it just then?
"There are more things in Heaven and Earth, Horatio…" came an androgynous, golden echo, followed by silvery laughter.
A wolf howled in the distance and they felt an intense heat between them.
Each had an arm plunged inside an intense light, which burned like a star, and held them fast.
The heat became searing pain as their arms were consumed in the progressive supernova, threatening to overtake them at any moment.
It pushed at the boundaries they created but never went far beyond.
Between them, and only them, they held its power at bay.
The explosion began to reverse itself, drawing the fires and blinding light back inside itself until the air was once again cool, and their sister with her overbite, sharp chin, and blonde waves stood between them.
Her eyes burned like twin suns, and she seemed not to be aware of her surroundings. She was staring ahead of herself into the heart of time.
Timelines spun and wove themselves around them, all in an endless dance of possibility vying to become reality. One shone bright and hot, eclipsing the others as it wound itself around the three, finally encircling them and beckoning them to gaze inside. Their sister couldn't tear her glowing eyes away from it.
When they looked with her, they saw it collapsing in on itself, breaking apart and dying.
As the destruction moved nearer to the eye of the storm, the damage seemed to be originating from a red planet, much like the one to which they had recently journeyed. The terrified screams of trillions of souls winking from existence created chaos within their minds.
The destruction zeroed in on a city encased in glass, and specifically on one inhabitant of that city. He wore a set of intricately embroidered, crimson robes, a neck piece bearing a strange mark of infinity, a gauntlet which glowed with blue energy, and a golden circlet studded with small red gems. He held a staff made of gold, with complex spirals at its top, and snarled at everyone. He witnessed the screams of billions, and could only muster a bitter contempt for everything around him. In that moment, their purposes in life became as clear as the shining dome meant to protect the burning masses. He had to be stopped. He was the enemy. He would end everything, and they had a chance to put it right.
Why else would they see something so grim unless they had a chance of preventing it?
He laughed as reality collapsed around him, and it was all they could do to keep from crying out in horror.
Gentle pressure met the hands holding their sister's, before she let them both go, and moved forward toward the maniacal man destroying everything.
They tried to stop her, keep her from going anywhere near the dangerous man, but found they couldn't move.
The man paid her no mind as she approached. He seemed not to see her even as she stood directly in front of him, but when she spoke, his icy blue eyes snapped to hers.
The evil in his eyes gave way to longing/greed.
The Doctor shook his head, coming out of the memory and looking expectantly at the men to whom they belonged.
Torin answered first.
"I say greed. He looked like he wanted to grab her and use her until she was empty, useless, and completely broken."
"It was longing," Lios contradicted. "Yes, he looked like he wanted to grab her, but it wasn't just for power."
"Anyway, it was weird, 'cos we definitely haven't ever met that man."
"And they definitely knew each other," Lios agreed.
The Doctor, who all too well knew their mystery villain, said nothing of his fear and suspicions, and instead went back to examining their joint memories.
He held out the hand encased in the gauntlet to their sister.
Temptation etched lines into her face, but in the end she made no move to take it.
They couldn't hear her next words, but the man's features contorted with rage. A bolt of blue energy from the gauntlet shot straight through her, but like any phantom, it did her no harm. She simply shook her head and smiled sadly. She stepped back toward her immobilised brothers, then waved her hand, and he began to lose his solidity, dissolving into little more than smoke.
As he faded from view, an unearthly melody began to play.
Music, like none they had ever dreamed, surrounded them and began to lull them to sleep. The Universe was singing to them, and they couldn't fight the drowsiness…
The Doctor let that memory fade into what followed, but let the memories pass without touching on them. He had seen enough of their grief to know that he didn't want to live through his meta-crisis dying.
Instead, he focused in on the hours of examining the girl's marking, and the futile efforts to interest her in doing anything but pour over the makeshift High Gallifreyan textbooks his meta-crisis made. The hours turned to days, days to weeks, and weeks to months as she tried to master the complex language without a master of her own. She spent the next few years doing little but pouring over everything he'd left.
The brothers worried, but Rose – blessed Rose Tyler and her stubborn streak – had had enough of the obsessing one day, and locked every book she could find in a steamer trunk, which she promptly loaded into one of their short-range cruisers, and sent down to the nearest habitable planet.
She told her daughter to go after it before it fell into the wrong hands, and changed history.
Selene had panicked and raged at her mum, but Rose took it in stride and told her to get on with it.
Selene was gone three days two hours and seven minutes, and they were just about to take the whole Star-liner in, when she came back covered in slime and algae from the swampy surface of the planet, and positively glowing with life and adventure.
They still caught her studying all the time, but she had become less openly obsessive, and more inclined to participate in family life.
"She wants to get to Gallifrey," the Doctor pointed out, "but it's gone. Rassilon is gone, and Gallifrey is gone. It's all gone. I destroyed it. All."
"W-we know—"
"Lios, she'll come back, because there's no way to get to where she wants to go. I don't understand why this was such a big secret. I could have ended this madness when we met with three simple words. They're. All. Dead."
"We know, Doctor. We know all about the Moment, but it's not that straightforward, is it?" Lios reasoned weakly.
"Yes, actually, it is. I destroyed the planet, and it's gone along with everyone on it. No one to fight, no one to save. That's as straightforward as it gets, by my ken."
Lios opened his mouth to object further, when the phone rang. The Doctor ran to it, instead of ignoring it for once, and answered.
"This had better be whom I think it is, and you'd better make it good."
"Hullo, Da— er – Bow-tie. Erm… I… I'm terribly sorry about all this. I was stupid, wasn't I? I'm sorry. I really am."
"Your brothers aren't half nearing distraction, you know."
"Yes, I know, but, well, er… Tell them to stop worrying. They needn't blame themselves. This was completely my fault, and…"
Torin was hovering, and obviously fighting the impulse to grab the phone and shout at his sister.
"Torin would very much like a word, I think."
"No! No. Actually, I don't have a lot of time so – er – Doctor, I'm stuck. Can you pick me up at the coordinates I'm sending?"
"Of course, but Selene, what—"
"I'm alright. I'm fine. Just come, please."
"Mates, right? I trust you, and you trust me? That's how it works with mates, right?"
The Doctor stayed silent as he mulled over her words.
Something wasn't right.
She was telling him something, but was it that she really needed his trust, or that he should be wary going in after her?
A set of coordinates appeared on his monitor.
"I'm coming to get you—oi!"
Torin really did reach out and snatch the receiver this time, though Lios, who had been hovering, made a valiant effort to wrest it from both of them for himself as well.
Torin was easily tallest, and held it out of reach, then climbed on the jump seat, put a trainered foot in Li's face, held the Doctor back by the forehead with his free hand, and put the receiver to his ear to hear his sister's soft laughter and a muffled sniff.
"Ha!" he cried in triumph. "You'd think you've been gone a few years and not a few minutes with all the sorry sods 'round here, eh? Alpha, I… oh."
The line was dead.
"That's a bit more than disappointing." He jumped back down and hung it up with a scowl. "Where did she get stuck then?"
"Odd," the Doctor remarked as he input the coordinates. "The Tower of London. Twenty-first century. I'm not picking up your ship but the TARDIS isn't able to land inside either. Very odd."
"Really?" Torin intoned in curiosity as he peeked over the Doctor's shoulder. "Has that ever happened before?"
"No, and I can't say I like it very much either."
"What could do that?" Lios asked.
"Humans," he said, as if it explained everything. "Humans who have things they shouldn't. Well, looks like she might be in a bit of a pickle. Shall we go find out what kind of trouble she could get into in," he glanced at the watch on his wrist and whistled wryly, "sixty-eight minutes and twelve seconds?"


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Mitochondrial calcium uniporter is a nodal regulator of physiological and pathological stress responses in myocardium
Document Type
Date of Degree
Spring 2016
Degree Name
PhD (Doctor of Philosophy)
Degree In
Molecular Physiology and Biophysics
First Advisor
Anderson, Mark E
First Committee Member
Adams, Christopher
Second Committee Member
Lee, Amy
Third Committee Member
Russo, Andrew
Fourth Committee Member
Schmidt, Thomas
Fifth Committee Member
Spitz, Douglas
A long held hypothesis in mitochondrial biology holds that increases in mitochondrial Ca2+ levels stimulate the activity of matrix dehydrogenases that catalyze production of NADH and eventually donate electrons to electron transport in order to increase ATP formation. At the same time, mitochondrial Ca2+ overload is a deleterious event leading to opening of the mitochondrial permeability transition pore, increasing reactive oxygen species and initiating pathways that contribute to cell death. These fundamental hypotheses are best studied in the heart because of the critical energy supply-demand relationship in myocardium, but were untestable in vivo until the discovery of the mitochondrial Ca2+ uniporter (MCU). The molecular identity of the MCU pore forming subunit was recently discovered, which allowed me to study a transgenic mouse with myocardial delimited expression of a dominant negative MCU.
My lab developed mice with myocardial-delimited transgenic expression of a dominant negative MCU to test these fundamental hypotheses and to determine how MCU controls physiological and pathological stress responses in vivo, ex vivo, and in situ. My studies provide new, unanticipated information that contributes to our understanding the relationship between mitochondrial Ca2+, oxygen utilization, cardiac pacemaking and pathologic stress responses in heart. Here, I show that mice with myocardial-targeted MCU inhibition have hearts with surprisingly high oxygen consumption rates due to elevated cytoplasmic Ca2+ in response to physiological stress. Loss of MCU effectively preserved inner mitochondrial membrane potential and prevented an oxidative burst thought to drive myocardial injury and death, but nevertheless failed to protect myocardium from ischemia-reperfusion injury. Increases in oxygen consumption, elevation in cytoplasmic Ca2+ and transcriptional reprogramming mitigate the protective actions of MCU inhibition in vivo. Mice with myocardial selective MCU inhibition have a reduced response to isoproterenol-induced heart rate increase but have normal baseline heart rates. My studies provide novel insight into how MCU contributes to myocardial Ca2+ homeostasis, metabolism, and transcription leading to surprising actions on physiological and pathophysiological responses in heart.
Public Abstract
Heart disease is the most common cause of death in the western world. The heart requires large amounts of energy to pump oxygen rich blood to peripheral organs. This energy is supplied by organelles called mitochondria, colloquially known as the powerhouse of the cell. Ca2+ entry into mitochondria has long been hypothesized to increase the ability of mitochondria to produce energy. This hypothesis was untestable in living animals until 2011 when the identity of the mitochondrial calcium uniporter (MCU) was discovered. MCU forms the pore for Ca2+ entry into mitochondria. I studied mice expressing a mutated form of MCU (DN-MCU) only in the heart. I hypothesized that the DN-MCU expressing mice would be unable to respond to physiological stresses. Additionally, mitochondrial Ca2+ overload can trigger maladaptive responses that lead to heart injury and cell death. I hypothesized that DN-MCU mice would show protection from cell death in response to a pathologic condition known to increase mitochondrial Ca2+. I found that DN-MCU mouse hearts had mitochondria with lower Ca2+ than normal mice, lower enzyme activity of Ca2+ sensitive enzymes and normal heart function at baseline. Electrically stimulated DN-MCU hearts had higher oxygen consumption when paced because of higher Ca2+ outside of mitochondria, suggesting cardiac inefficiency. Despite lack of Ca2+ entry into mitochondria, DN-MCU hearts were not protected from cell death after ischemia-reperfusion injury, a model known to involve mitochondrial Ca2+ overload. These data suggest that MCU inhibition alters responses to physiological stress, but doesn't protect hearts from cell death.
publicabstract, Calcium, Heart, Ischemia-Reperfusion, MCU, Mitochondria, Myocardium
xiv, 126 pages
Includes bibliographical references (pages 108-126).
Copyright 2016 Tyler Paul Rasmussen
Recommended Citation
Rasmussen, Tyler Paul. "Mitochondrial calcium uniporter is a nodal regulator of physiological and pathological stress responses in myocardium." PhD (Doctor of Philosophy) thesis, University of Iowa, 2016.


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Early Indicators That Your Automobile Requires Brake Service Or Break Repair
Throughout braking, the kinetic power of the moving vehicle is converted into thermal energy by way of friction at the disc and pad interface. To sum up how I really feel about FMC/John Beam brake lathes, they are a terrific machine that competes effectively with the Ammco series of brake lathes, and is yet another utilized brake lathe that I would advocate. Apart from brake fluid, pads—and shoes on some older car models with rear brake drums—are the only component in the program in want of regular replacement, but pads can also give you signs of prospective technique problems. So if you see your brake components obtaining red then one thing is almost certainly stuck in the on position.
A visual inspection of the brake pads and shoes can also aid reveal lining situation, possible program problems you may not be aware of, and avoid an expensive repair—or an accident. The booster multiplies the stress you apply to the brake pedal to assist you slow or cease your vehicle. Other frequent causes: A blocked brake line, contaminated brake pad lining, or inoperative brake caliper. Whether you are dealing with squeaky brakes, vibrations, or some other brake difficulty symptom, don't ignore the signs.
Worn out or damaged brake pads could produce sounds you ought to spend interest to and investigate as they seem. There is a tiny switch appropriate below the brake pedal that when you push it, tends to make the lights go on, i'd suggest acquiring that replaced, it will probably repair your issue. This model was very well-known, and you will still see many of them in brake shops.
Go, feel cost-free to check out them as frequent as you can, Les schwab will in no way get tire of providing you satisfying service in any automotive solutions that you need in a firm which offers you merely the very best. Naturally I was in a position to sell my rebuilt machines extremely very easily to the brake shop specialists. Usually, this symptom indicates a dilemma with a brake assembly on one of the wheels. I was able to give a ten year warranty on the key components of these lathes when set up and maintained by the service book. The regular kit with the FMC is really good, and has adapters for most disc and drum brake machining set-ups.
If the Secondary Piston loses fluid, the movement of the brake will still generate the hydraulic hyperlink in between the Major and Secondary Piston. When this occurs, you'll feel the steering wheel or brake pedal shaking or vibrating as you slow down or stop the car. The grinding noise becomes louder whilst i am driving faster and decrease while i press on the brake. When I press the brake pedal and come to a total cease, the car will give vibrate in the course of quit. Now that the pressure has been designed in the brake program, the stress will react on the pistons in the disc brakes and drum brakes. Caution: On vehicles with Anti-lock Brake Systems (ABS), specific procedures may be essential to bleed the system.


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1999 subaru rs ej25 hybrid
20 Posts
Discussion Starter • #1 •
Hey guys I have a 99rs with a 2002 swap that I bought. The obd2 doesn't work and the check engine and abs lights are on this is a pic of the obd2 port wires and the ecu. Can anyone help why I can't get a connection??


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Easy Plumb Slimline Rectangle Shower Tray TRSRL
This easy plumb slimline tray is super strong and lighweight meaning an easy fit and more importantly a tray that will last for many years. Standing at a total of 60mm in height (extending to 127mm if the riser leg kit is used) this comes in 2 popular sizes.
Easy to fit, this tray is suitable for all of our shower cubicles measuring 1000 x 800mm and 1200 x 800mm. Very popular with plumbers and bathroom fitters this tray is a huge hit with trades persons simply because of its easy installation and the knowledge that problems rarely occur.
If the waste needs to be sited above floor level then you will need the riser kit. There is also the option of purchasing a compatible waste kit.
Write Your Own Review


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Since the launch of the last patch (Feb 27, 2019) Supercell has given all Brawl Stars players the option of sorting their Brawlers (hurray!)
We think this is a great addition to the game, as it's now much easier to get a quick overview of which Brawlers that it makes the most sense to push for more trophies.
It's also really simple to do, involving only two steps! This is how it's done:
- Click the Brawlers icon at the left side of the main screen
- Click the black field at the top with the text "By Rarity"
By following the steps above, you're able to change the default settings for sorting your Brawlers. These are the different options you're provided with:
- By Rarity
- Most Trophies
- Least Trophies
- Closest to Next Rank
- Power Level
- By Rarity Descending
Now go ahead and try it out for yourself and see what works the best for you!
– Brawl Stars News crew


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Cotton twill taping at collar opening for strength mandarin collar. Moisture-controlling materials allow air to flow close to the skin and draw heat away from the body. Reinforced taped seams for added durability. Bartacks at key pressure points for increased strength.
Washing Instructions
Machine wash cold (30° C). Do not bleach. Do not tumble dry. Hand dry. Iron at low temperature. Do not dry-clean. Wash with like colours. Wash inside out. Do not wring or twist.


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Wales is a separate country in the United Kingdom, just like Scotland, and is known for its rich history, diversity, cultural liveliness and much more. The country is broadly divided into mainland and its islands, which make for beautiful sceneries, picturesque beaches and a whole lot of tourism. If you love the sea and beaches, you can take a walk on the Wales Coast Path and there is a good variety of wildlife if you appreciate nature. Cardiff and Swansea are the most popular cities in the country, offering a host of entertainment and food options for visitors and residents alike.
Average Price for property in Wales is around £176,644 which varies based on type of property you are interested in and ranges from £259,754 for detached house to around £155,618 for semi-detached. Similarly terraced house is around £123,242 and a flat is worth £178,342. Values have been changing and have risen £615 in last 3 months alone. Similar historical trend can be observed in price changes e.g. prices changed £865 in last 6 months, £8,904 in last 1 year, £12,787 in last 2 years, £12,511 in last 3 years, £11,460 in last 4 years and £7,026 in last 5 years.Currently average asking price of a property in Wales is around £365,746 based on approximately 33,279 properties for sale. Same is the case with rental options based on 191,033 properties up for rent, average asking rent is around £1,906 per month.
Buyers are willing to pay high dollar prices to grab these properties because of the recent trend in real estate investment especially in Wales area. In last 1 year alone average price buyer paid is around £157,528 based on approximately 33,279 sales in Wales area alone. If you compare it to last 3 years sales of 96,916 properties where buyers paid around £154,068. It has been same for some time now for e.g. if you take an average of amount paid in last 5 years, it comes to around £153,344 for 155,059 and average amount paid for purchase of approx. 210,781 properties sold in last 7 years comes to about £153,142 per sale.
Semi-Detached | 3 Bd | -- Ba
Semi-Detached | 3 Bd | -- Ba
Blaenau Gwent End of Terrace | 3 Bd | 1 Ba
Apex are pleased to offer for rent this 3 bedroom end terrace house with accommodation comprising of....
Blaenau Gwent Terraced | 2 Bd | 1 Ba
Two bedroom house in the popular village of Deri with accommodation comprising of two bedrooms, loun....
Blaenau Gwent Terraced | 3 Bd | 1 Ba
We are pleased to offer for sale this well presented mid terraced house with accommodation comprisin....
Bridgend Town House | 3 Bd | 1 Ba
3 Bedroom, 3 story terrace house. Hallway leading to large open plan Lounge, stairway down to fitted....
Bridgend | 3 Bd | 2 Ba
3 Bedroom semi detached house. Hallway to Lounge, Cloak room, fitted Kitchen. Stairs to first floor....
Breakdown of asking prices for homes of different sizes show that price varies clearly based on no of bedrooms and type of house. Asking price for a house with 1 bedroom is around £141,370, £158,208 for a 2 bedroom house, £227,243 for a 3 bedroom house, £409,622 for a 4 bedroom house and £705,693 for a 5 bedroom house. For a flat similarly the prices varies from £230,222 for a single bedroom to £324,190 for a 2 bedroom Flat. Same is the case with 3 bedroom flat £820,675, £1,712,274 for a 4 bedroom flat and £2,880,701 for a 5 bedroom flat. To sum up the asking prices for properties in Wales it comes to around average £215,673 for 1 bedroom property, £234,585 for 2 bedroom, £273,125 for 3 bedroom, £432,678 for 4 bedroom and £732,905 for a 5 bedroom property.
Rent per calendar month varies similarly based on type and size of the house. If you look at the rents per month for houses alone it can vary from £722 for 1 bedroom to £841 for 2 bedrooms, £1,093 for 3 bedrooms, £1,753 for 4 bedrooms and £2,500 for 5 bedrooms house. But if you are interested in renting a 1 bedroom flat then rent per month can be around £1,173. As the no. of bedroom increase so will the rent e.g. for a 2 bedroom flat it will be around £1,661, £3,190 for 3 bedroom, £4,766 for 4 bedroom and around £5,540 for 5 bedroom flat. You should be generally be expecting around average £1,088 rent per month for single bedroom property, £1,407 for 2 bedroom, £1,713 for 3 bedroom, £2,180 for 4 bedroom and approximately £2,807 for a 5 bedroom property in Wales area.
Newport Detached | 3 Bd | 1 Ba
Wrexham Detached | 4 Bd | 2 Ba
Wrexham Detached | -- Bd | -- Ba
Swansea Semi-Detached | 3 Bd | 2 Ba
Cardiff Terraced | 3 Bd | -- Ba
SOLD SIMILAR PROPERTIES REQUIRED FOR WAITING BUYERS. CALL 02920561111 TODAY FOR A FREE VALUATION 3 b....
Flat | 2 Bd | 1 Ba
Flat | 2 Bd | 1 Ba
Flat | -- Bd | -- Ba
Cardiff Property | -- Bd | -- Ba
Cardiff Property | 4 Bd | 2 Ba
The property you are viewing is located at 7 Clos Coed-Y-Dafarn, Lisvane, Cardiff CF14 0ER. This is....
Cardiff Property | 6 Bd | 3 Ba
The property you are viewing is located at 9 Mundy Place, Cathays, Cardiff CF24 4BZ. This is a 6-bed....
Cardiff Property | 5 Bd | 3 Ba
Cardiff Property | 5 Bd | 4 Ba


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Articles Tagged 'MXP'
blu-express takes over seven belleair routes
blu-express starts serving Albania from the Italian market.
Happy birthday easyJet – 18 years, 850 route launches – hear the anna.aero tribute song
This November, easyJet, Europe's third biggest airline in terms of passenger numbers, marks 18 years of operations. From inauspicious beginnings, it has become a major force in European air travel, and is arguably one of only two truly pan-European airlines. We take a closer look at the airline's development and the evolution of its leading […]
easyJet growing fastest in UK, Switzerland and Italy; Luxembourg, Norway, Romania and Russia are newest country markets
easyJet's capacity growth this summer is around the 2% mark, but that hasn't stopped it adding four new countries to its network. We reveal which country markets are growing (and shrinking), and which airports have seen the biggest increase in flights this summer. We also show which routes are being "dropped" this winter.
germanwings takes over more Lufthansa routes
germanwings starts flights from Berlin Tegel Airport and Hamburg Airport in Germany, replaces Lufthansa
Emirates inaugurates two routes in one day
Emirates launches two new services with Milan Malpensa Airport to New York JFK Airport; plus Dubai Airport to Clark Airport in the Philippines.
Stockholm Arlanda celebrates Cake prize; Milan Malpensa shows off Route award; Birmingham charity cycle ride; Peach welcomes passenger #3m, and; a trio of news stories from the world of Ryanair
Another bumper issue of Network Planning Community News, yet again boasting some of last week's anna.aero award winners, passenger milestones being recorded, deals getting signed and other newsworthy events from our peers from around the world.
TWIN JET's dynamic 12 months; weekly flights up 13.7%; plus new routes such as Le Havre to Lyon
TWIN JET will grow weekly flights by 13.7% this September, when compared to same month last year, including starting new routes to places like Milan Malpensa to Toulouse. We also look at what points the French regional carrier has dropped in the last 12 months.
TWIN JET takes over Toulouse to Malpensa from easyJet
TWIN JET starts flights from Toulouse Airport in France to Milan Malpensa Airport in Italy.
Darwin Airline – 'the Origins of a Network' continues to evolve with new Cambridge and Leipzig bases
Darwin is no longer merely associated with famous English naturalists (who studied at Cambridge University) or that place right in the north of Australia, it is also a fast-expanding, Swiss-based regional airline that has grown by 165% in the last 12 months.
Darwin Airline launches Cambridge and Leipzig bases
Darwin Airline launches Cambridge Airport to Amsterdam Airport Schiphol, Geneva Airport, Milan Malpensa Airport, Paris CDG Airport; plus, Leipzig/Halle Airport to Amsterdam Airport Schiphol and Paris CDG Airport.
Alitalia plans 40-route international expansion from Rome Fiumicino, Milan and Venice
Alitalia's new CEO has an "Industrial Plan" for up to 40 new international routes in the next three years. We look at which routes the airline has already added this year, and what has happened to some of the domestic markets that it (and Air One) are no longer serving this summer.
WOW air now serves Milan from Reykjavik
WOW air launches seasonal services from Reykjavik/Keflavik Airport to Milan Malpensa Airport.


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I had an absolute blast at the Take a Vet Fishing event on Lake Waubesa Today. I signed up to take a vet out for the event and I'm absolutely glad I did.
I'd never fished Waubesa before, but tried to keep it simple. Long drifts over a mainlake point with a mix of sand, rock and weeds. We were casting jigworms, and Steve had a rod out with live bait on a split shot rig. Like I said, simple.
We hit some active fish early and caught a mixed bag of both largemouth
and smallmouth bass. After a bit, we also started picking up some
walleyes and even grabbed a nice pike. Fished 7-11:30am, ended with more than a dozen mixed.
It was a fantastic event, well organized and well executed. Boats were launched/taken out quickly and in orderly fashion. I'm really looking forward to next year.
Here's Steve with a nice smallie from today.
Sunday, June 9, 2013
Take a Vet Fishing
Posted by Chris at 8:02 PM
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Modern agricultural practices have been a threat to life on Earth and are a factor in virtually every growing environmental and health problem. Farmers 100 years ago would have laughed at such a thing happening, as agriculture is necessary for food production and, therefore, life. However, it is indisputable today we are drastically and negatively affecting air, soil and water.
Scientists are now calling for the definition of a new geological age, moving Earth from the Holocene era of stability into Anthropocene, marked by significant and permanent changes to the Earth from mankind. In the past decades, food production has focused on efficiency and lowering immediate costs.
This approach has been responsible for skyrocketing disease statistics and a faltering ecosystem struggling with rapidly reducing clean water supplies and soil unable to support plant life. Toxic agricultural chemicals are polluting the air and waterways, threatening the entire food chain and disrupting normal rainfall patterns.
Poorly Designed Food Production Negatively Impacts the Environment
Today's large agrichemical businesses were designed to increase production and financial gains. While traditional farming sustained mankind for thousands of years, industrial farming has managed to create a series of unsustainable situations in less than 70 years. For instance, topsoil destruction and erosion are exacerbated by monocropping and tilling.
Maria-Helena Semedo of the Food and Agriculture Organization of the United Nations has warned at the current rate of topsoil degradation, all the world's topsoil will be gone in less than 60 years.1
These changes can potentially create another dust bowl. In the 1930s farmers plowed the Southern Plains. After three consecutive drought years the area turned into an uninhabitable and unworkable dust bowl. Current research suggests modern agricultural methods will not protect us from a repeat of those devastating conditions.2
Bioethicist George Dvorsky3 believes a common expectation is a dust bowl would not occur since 30 percent of produce production is irrigated in the U.S., and corn is not planted in severely drought-stricken places. However, according to simulations, if the U.S. were to experience the same kind of drought today, we'd lose nearly 40 percent of our commodity crops.
Degradation of topsoil and industrial farming, which uses an estimated 80 percent of our freshwater supply,4 means much water is wasted as it washes through the soil and passes the plants' root systems. In seeking efficiency, large-scale industrialized agricultural endeavors have created a reduction in diversity.
Monoculture farming significantly contributes to dietary changes promoting poor health in both humans and the soil. According to a report by the Royal Botanic Gardens in the U.K., one-fifth of all plants worldwide are threatened with extinction, primarily through the expansion of agriculture and monoculture farming.5
EAT-Lancet Commission Goals Are Far-Reaching, but Results Fall Short
In 2016, the Stockholm Resilience Centre,6 Lancet7 and EAT announced the EAT-Lansing Commission to investigate connections between nutrition, health and the ability of the planet to sustain the food supply. According to their site, EAT is:8,9
"[A] global, nonprofit startup dedicated to transforming our global food system through sound science, impatient disruption and novel partnerships … founded by the Stordalen Foundation, Stockholm Resilience Centre and the Wellcome Trust to catalyze a food system transformation.
To ensure success, we connect and partner across science, policy, business and civil society to achieve five urgent and radical transformations by 2050."
The commission acknowledged food systems are a major source of greenhouse gas emissions and users of freshwater, each leading to biodiversity loss and land-use changes, and triggering dead zones in lakes and coastal areas.
The commission's goals were to bring together scientists from around the globe to reach a scientific consensus defining a healthy diet, a sustainable food system, how to achieve a healthy diet from a sustainable food system and the solutions and policies needed.10
To date the American Heart Association,11 American Diabetes Association12 and the Centers for Disease Control and Prevention13 do not have a solid consensus on what constitutes a healthy diet. However, many of their experts do acknowledge lowering carbohydrates and sugar intake, and increasing amounts of vegetables and healthy fats are important steps.
One of the initiatives of EAT is to bring together an "ambitious global business partnership" for a "systemic approach across the food system to drive industry change." Their partners14 include Bayer, Cargill, DuPont, Kellogg's and Syngenta, each with its own desire to maintain financial health through product promotion, including genetically engineered (GE) seeds, insecticides, pesticides and cereals.


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Raja Schaar is an industrial designer, museum exhibition designer, and STEAM education evangelist. Her research focuses is on K-16 design pedagogy, innovation and entrepreneurship, human-centered design methodologies, STEM/STEAM education, biologically inspired design, and sustainability. She is an active museum exhibition designer working with community organizations, National Parks, and museums all over the country.
Raja works to infuse her teaching with human-centered design methodologies grounded in making and prototype-testing. Schaar pushes her students to apply design thinking to the development of devices and products that positively impact the lives of users. Her approach is fueled by over 15 years of experience as both an industrial designer and university design instructor. Before joining Drexel's faculty Raja taught at GA Tech in both the Colleges of Design and Engineering. Favorite Course topics include medical devices, wearable technology, exhibition design, sustainable design, biologically-inspired design, and service design.
In addition to her decade-long practice as a museum exhibit designer and design educator, Raja has also served as the Coordinator of School Programs at the High Museum of Art, and the Director of Programs and Operations at Museum of Design Atlanta. Raja speaks on Industrial Design, STEAM and design education at conferences and workshops all over the US, and is currently working on revolutionizing the breast pump.
Ackerman, J. and Schaar, R. (2016). *Clinical Observational Design Experience – A Large Design Oriented Clinical Immersion Course Based in an Emergency Department. *Unpublished Paper to be presented *at *VentureWell Open 20th annual conference, Portland*. *
Schaar, R. Jacobson, M., and Rains J. (2015). *Jump-starting Biomedical Design Education in the Sophomore Year: A human-centered approach. *Paper presented at VentureWell Open 19th annual conference, Washington D.C*. *
Schaar, R. and Shankwiler, K. *Design Gateway: Pedagogical Discussion of a Second-Year Industrial Design Studio*. 24th National Conference on the Beginning Design Student, 2008.