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Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide
BMC Cancer. 2011;11(1):524 DOI 10.1186/1471-2407-11-524
Journal Title: BMC Cancer
ISSN: 1471-2407 (Online)
Publisher: BMC
LCC Subject Category: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Country of publisher: United Kingdom
Language of fulltext: English
Full-text formats available: PDF, HTML
Yan Tao
Skaftnesmo Kai
Leiss Lina
Sleire Linda
Wang Jian
Li Xingang
Enger Per
Time From Submission to Publication: 19 weeks
Abstract | Full Text

Abstract

Background

Expression of neuronal elements has been identified in various glial tumors, and glioblastomas (GBMs) with neuronal differentiation patterns have reportedly been associated with longer survival. However, the neuronal class III β-tubulin has been linked to increasing malignancy in astrocytomas. Thus, the significance of neuronal markers in gliomas is not established.

Methods

The expressions of class III β-tubulin, neurofilament protein (NFP), microtubule-associated protein 2 (MAP2) and neuron-specific enolase (NSE) were investigated in five GBM cell lines and two GBM biopsies with immunocytochemistry and Western blot. Moreover, the expression levels were quantified by real-time qPCR under different culture conditions. Following NSE siRNA treatment we used Electric cell-substrate impedance sensing (ECIS) to monitor cell growth and migration and MTS assays to study viability after irradiation and temozolomide treatment. Finally, we quantitated NSE expression in a series of human glioma biopsies with immunohistochemistry using a morphometry software, and collected survival data for the corresponding patients. The biopsies were then grouped according to expression in two halves which were compared by survival analysis.

Results

Immunocytochemistry and Western blotting showed that all markers except NFP were expressed both in GBM cell lines and biopsies. Notably, qPCR demonstrated that NSE was upregulated in cellular stress conditions, such as serum-starvation and hypoxia, while we found no uniform pattern for the other markers. NSE knockdown reduced the migration of glioma cells, sensitized them to hypoxia, radio- and chemotherapy. Furthermore, we found that GBM patients in the group with the highest NSE expression lived significantly shorter than patients in the low-expression group.

Conclusions

Neuronal markers are aberrantly expressed in human GBMs, and NSE is consistently upregulated in different cellular stress conditions. Knockdown of NSE reduces the migration of GBM cells and sensitizes them to hypoxia, radiotherapy and chemotherapy. In addition, GBM patients with high NSE expression had significantly shorter survival than patients with low NSE expression. Collectively, these data suggest a role for NSE in the adaption to cellular stress, such as during treatment.


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Xstream is nominated in 2 categories for the Streaming Media Readers Choice Award 2016
We're excited and humbled to have been nominated in 2 categories in the 2016 Streaming Media Readers Choice Award. The award is an annual industry competition hosted by Streaming Media Magazine, which lets readers choose their favorite streaming technology.
Xstream and our turnkey OTT Platform, Xstream MediaMaker™ has been nominated in the following categories:
- OTT Platform for MSO and MVPD: As MSOs and MVPDs deliver more over-the-top content, they're looking to more robust and functional solutions than traditional media and entertainment video platforms can offer.
- End-to-End Workflow Solution: When a content owner, whether entertainment or enterprise, is looking for a soup-to-nuts video workflow solution that includes professional services and consulting, these are the service providers they turn to.
Cast your vote here today!
Powerful and proven, Xstream MediaMaker™ is an end-to-end turnkey OTT Platform, empowering leading operators, broadcasters, media companies and content owners across the world to seamlessly create, manage, distribute and monetize their premium content across all networks and devices. Learn more about Xstream MediaMaker™
Your vote is highly appreciated!
Xstream is proud and honored to be nominated and we would be thrilled to win one of them! We recognize that there's tough competition this year, so we would truly appreciate your vote. We're also delighted to see that so many of our awesome partners are amongst the nominees. Congrats – you got our vote! The poll ends September 26th, so cast your vote today!
Thank you! We appreciate your support!

subset: commoncrawl


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Prosecutor of the Special Department for War Crimes of the Prosecutor's Office of Bosnia and Herzegovina has issued an Indictment against the following persons:
1. Radovan Paprica aka 'Papro', born in 1953 in Foča
2. Slavko Ognjenović aka 'Mačak' born in 1965 in Foča.
These accused persons are charged with acting, as a members of the Republika Srpska Army, in contravention of the provisions of the Geneva Convention Relative to the Protection of Civilian Persons in Time of War, during the war and the widespread and systematic attack against the civilian Bosniak population from the area of Foča and its surroundings.
These persons are charged with war crimes involving rape and sexual abuse in wartime, which has left serious consequences on injured parties.
The aforementioned accused persons are charged with the criminal offense of Crimes against Humanity, referred to in Article 172 of the Criminal Code of Bosnia and Herzegovina.
The Indictment has been forwarded to the Court of Bosnia and Herzegovina for confirmation.
Dear Media Representatives, when transmitting news please bear in mind that persons referred to in the news and information of the BiH Prosecutor's Office, have the status of a suspect or an accused person. Let us remind you of the principle of presumption of innocence, which defines that no person shall be considered guilty until his/her guilt has been established by a final verdict.


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During the Great Fast, Sisters from the Generalate participated in special services of the Way of the Cross (Stations of the Cross). On March 24, 2019 the annual Way of the Cross took place at the Saint Sofia Minor Basilica, where the cross was carried to different stations by various religious organizations, monastic Orders and communities.
The Sisters of the Order of St. Basil the Great were represented by the Sisters from the Most Holy Trinity Province (Ukraine) missioned to St. Sofia and Sister Nazariya Mykhayliuk, OSBM representing the Generalate.
A most unique invitation came from the Benedictine Fathers for our Sisters to participate in the Way of the Cross, which took place on April 5 in the Church of St. Anselm on the Aventine Hill. Participating from the Generalate were Sister Lydia Anna Sawka, Sister Nazariya Mykhyaliuk and Sister Atanasia Anheluk. Reflections at the eighth station were read by Sister Kornelia Zhupnyk, OSBM from the Most Holy Trinity Province in Ukraine, who is studying in Rome at the Pontifical Institute of Spirituality (Teresianum). This service of the Way of the Cross was especially celebrated for monastics and served to unite in prayer members of various Orders and religious communities.
On April 7, 2019 Sister Nazariya Mykhayliuk, OSBM joined the Ukrainian group of Mothers in Prayer in Italy in the Way of the Cross, which took place at Santa Scala (Holy Stairs) Church, located near St. John Lateran Basilica in Rome. The service was celebrated by Reverend Father Efrem Konchak, OSBM. Following the service, the participants had the opportunity to climb on their knees the Holy Stairs which Christ walked on His was to Pontius Pilate. This is the first time in 300 years that the wood covering the stairs has been removed for 40 days allowing pilgrims to actually see and touch the original stairs, worn and grooved in many places by years of pilgrims praying on their knees.


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Andreas Kohl returns to the Roadburn side programme to impart further wisdom
Almost becoming a regular sit-in, Andreas Kohl, Senior Manager at Optimal Media, currently the world's biggest pressing plant, will bring his expertise to Roadburn's side programme again this year.
With hampering growth such as pressing capacities, new machinery now being widely available but still facing issues like shortage of well-trained and enthusiastic personal vinyl records remain one of the most discussed topics in the music industry and among fans. Andreas has been holding Q&As and lectures on these topics three times now at Roadburn with different each time. In 2019 he will again give an insight on new technology hitting the market and the current state of manufacturing the black gold in general. The short lecture and update on the current state of things will be followed by a Q&A session where every imaginable detail can be discussed and questions may be asked involving details of record manufacturing. Andreas will bring knowledge and passion to the discussion and answer all these questions.
This informative session could just be the perfect companion should you be already buzzing with ideas about how to release your own music following Saturday's panel discussion. Consider yourself invited and feel free to bring your ideas, comments and interest to a cozy campfire talk about the passion for the grooves we all share.
V39, Sunday April 14, 3.30pm


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UPDATED: San Juan Bautista Mayor Dies 12-07-18 05:35 DC
San Juan Bautista Mayor Jim West died on Thursday. No cause of death has been released for the 75-year-old West, who was a city councilman for the past four years and before that also served on the San Benito County Healthcare District Board.
He was a longtime employee of Graniterock,
According to the City of San Juan Bautista website, West had been involved in San Benito County for over 20 years. In recent years, he was elected to the San Benito County Health Care District, appointed to the San Benito County's Parks & Recreation Commission and was vice chairman of the county's General Plan Update Committee.


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Whats App PLUS Holo Apk
The WhatsApp PLUS Holo is a custom mod that is for the WhatsApp messenger. Basically, the WhatsApp PLUS Holo custom mod allows a WhatsApp user to change the entire them of Whatsapp's Chat theme.
The WhatsApp PLUS Holo is a theme for the Whatsapp messenger app that is named as Holo. When a user downloads and installs the WhatsApp PLUS Holo they are getting an entire new and different look for their Whatsapp messenger app.
The WhatsApp PLUS Holo doesn't just provide a stock new theme for Whatsapp though, the WhatsApp PLUS Holo also provides its users with a variety of options that will allow them to change and customize the look of their Whatsapp messenger app screen.
If you are a WhatsApp user and your really love this messaging app and use it a lot, but are starting to get a little bored and maybe fed up with the look of WhatsApp's default theme then the WhatsApp PLUS Holo custom mod is a great mod to use to breath new life into your WhatsApp messenger app. By downloading and installing the WhatsApp Plus Holo custom mod, you can change the look and overall them of your WhatsApp app any way that you would like to.
In this post, were going to show you how you can download and install WhatsApp Plus Holo so that you can begin tweaking the look of your WhatsApp app the way you like. We will also be providing you with a link where you can easily download Whats App PLUS Holo. Follow along.
What To Do If You Want To Download And Start Using The WhatsApp PLUS Holo:
- The first thing that you will need to do if you want to start using WhatsApp PLUS Holo is to download a copy of the file. You can download it here: WhatsApp Plus Holo Apk
- You have to options when downloading this APK. You can either download it onto a PC then copy it to your device, or you can download it directly to your device. Use whatever your more comfortable with.
- Copy the APK file onto the SD card of your device.
- Open the file manager program that you use.
- Find the folder where the APK file was placed. Tap on the APK file.
- You will get a pop-up asking you to choose App Manager. Tap OK.
- Tap install. In a few minutes the installation will finish.
Have you installed WhatsApp PLUS Holo?
Share your experience in the comments box below.


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HANDi Maternity App launched at Musgrove Park
March 29, 2017
Building on the success of HANDi Paediatric in the South West, Technical Health is pleased to announce the launch of the HANDi Maternity App at Musgrove Park Maternity Unit in Taunton.
HANDi Maternity has been developed by the maternity team at Musgrove Park Hospital Taunton and is provided free for all women having their baby at the unit. This innovation was created in response to patients requesting easy access to the right local maternity information at the right time throughout their pregnancy journey.
The app provides a wealth of information relevant to women thinking about having a baby, during pregnancy and labour, and supporting baby in the early weeks of life. This includes a suite of videos throughout the chapters, a video tour of the department, national and local information leaflets and useful telephone numbers for contacting the unit and booking appointments. There is even a My Appointments section allowing the user to keep a record of all upcoming scans and midwife clinic appointments.
Providing the right information at the right moment along a healthcare pathway is a powerful way to help patients make better informed decisions about their care and raises standards across our health service. HANDi Maternity aims to do this and as well as supporting the patient it creates new efficiencies of practice, for example Musgrove Maternity unit estimate they spend around £12k a year on printing leaflets and so providing this content digitally, free and with an easy way to keep it all up-to-date through our content management system saves the department time and money.
Technical Health continue to successfully implement and support the creation of digital solutions for the NHS and has delivered Maternity as the next HANDI app in the series providing expert local advice and support for women having their baby at Musgrove Park.
Download HANDi Maternity for iPhone
Download HANDi Maternity for androidIf you would like any further information or HANDi Maternity in your region please do get in contact with us here


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Few people today remember what BCC actually stands for, but many knowledge workers don't know how to use BCC in email effectively, adding it more often than they should.
What is BCC?
BCC means "Blind Carbon Copy". In the old days of typewriters and paper memos you made carbon copies (CC) by inserting carbon paper between the sheets; every recipient would get the same text, so they could all see who is on the distribution list. A "blind" copy was one whose recipient was not seen by the others, a feat accomplished by removing the carbon paper before adding this recipient. All email clients today replicate this functionality, and people use it to send out copies of messages to hidden recipients in a clandestine manner.
TO vs. CC vs. BCC
There is a lot written about the distinction between To and CC recipients; the general consensus is that "To" means you have an action item, and CC means you don't – you're getting the message as an FYI (the question of why we burden the CC people with non-actionable email makes good food for thought, by the way). Meanwhile, the subject of BCC gets less attention, and people use it as they please.
That is seldom a good idea.
Major problems with the use of BCC
- With ubiquitous connectivity, blind messages can't be relied on to remain discreet. If you blind copy Jack on a message to Jill because you really don't want Jill to know you informed Jack, Murphy's laws will kick into action, and before you know it the truth will come out. One way or another – an inadvertent comment in the cafeteria line, a forwarded copy of the message through a third party, whatever – Jill will find out, and you will end up embarrassed or worse. The more deserving of secrecy the message, the greater the damage when it comes out.
- More generally, because blind copies are perceived as sneaky, the use of BCC runs contrary to the company culture of many organizations – those that actually mean the values on the posters that extoll openness, honesty and respect for people.
How to use BCC in email (if you cannot avoid it)
- When you're sending a blast email to a large distribution list, BCC is the only way to go. Otherwise, people will all be copied when some idiot hits Reply All instead of Replying to the sender. That leads to what is known as an Email Storm – many irate recipients will respond with a justified complaint, and enough of them will do it with Reply All again; like particles in a nuclear explosion, the angry responses multiply until they can actually bring the server down!
- When you want to remove someone from future responses in a thread, judicious use of BCC can help. This is typically seen in introductions: if David sent an email introduction to you and Mary, a wise response would start "Thanks David (moved to BCC) and hello Mary". Putting David on the BCC line will keep Mary's further communication with you out of his inbox. In this case you used BCC but informed them both of the fact, so nothing sneaky is involved.
Of course, at the root of all these cases is the insight that you should think before you act – a wise strategy in general…especially with email communication.


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Let the reader understand-
Daily Archives: 21 Nov 2017
New Testament Post at the University of Geneva
The Faculty of Theology of the University of Geneva (cf. http://www.unige.ch/theologie/) invites applications for a position as Senior Lecturer in New Testament and Early Christianity. The application (exclusively online) is open till December 10, 2017. Starting date is August 1st 2018 (or upon agreement). It is a stable, well paid position (first evaluation after four years). It's an interesting job opportunity (both in teaching and research) for a young scholar (PhD in Theology or similar research field) in a pleasant and international context. For further information (and inscription), see: https://jobs.unige.ch/www/wd_portal.show_job?p_web_site_id=1&p_web_page_id=30421
Via Steve Walton at BNTS.
Child Molesters are Worse Than Democrats, or Republicans, or Independents
But if you would rather vote for a child molester than a Democrat, or a Republican, or an Independent… I feel so sorry for you. Hell is going to be super unpleasant for you. From now on before I vote for anyone i'm going to ask them if they think a child molester is a better choice than someone of a different party. If they say yes, I will fight their election every waking minute.
Bible in Arts- A Free Online Journal from the German Bible Society
The first volume of the new free online journal "Bible in Arts" (BiA) has just been published on the scientific online portal of the German Bible Society:
From now on, a new volume is to appear every year. We kindly invite you to take a look at the journal and to forward this e-mail to anybody who you feel might be interested in it.
The first volume of "Bible in Arts" focuses on King Solomon. The collected papers have been presented at the conference "Salomobilder in Barock und Moderne" (May 2016, in Linz). However, the focus on a single topic will be an exception. For the future, we are looking forward to receive papers from you dealing with various themes and aspects of the reception and the impact of the Bible in arts.
Univ.Prof. Dr. Susanne Gillmayr-Bucher
Institut für Bibelwissenschaft
Katholische Privat-Universität Linz
A-4020 Linz, Bethlehemstraße 20
A New 'Violence Free' Bible for the Special Snowflake on Your Christmas List
We know what you're thinking: why does the Bible have to be so, you know, violent? Any honest look at human history shows we've progressed beyond all that barbaric, blood-soaked, pillage-the-Canaanites Old Testament stuff.
It's the 21st century, after all, and we all know that love wins! God is all about peace, rainbows, and self-esteem. Nobody wants to open their Bible and get smacked in the face with images displaying the gory consequences of sin, the grisly certitude of death, and the murderous nature of the human heart. Wars? Yuck. Animal sacrifice? Bleck. Disembowelment? DISGUSTING.
Well, you're in luck. Just in time for the holidays, the Coalition of Progressive Christian Publishers has come together to bring us a new Violence-Free Version of God's Holy Word.
The publisher has graciously offered The Babylon Bee an exclusive selection of story summaries from the VFV:
- Angered by humanity's sin, God drowns the earth in a global flood of puppies and candy.
- As a sign of the covenant, God commands Abraham to get a lit "Shalom" tattoo on his wrist.
- The Israelites and their Egyptian captors collaborate to reduce their collective carbon footprint, causing the Red Sea to lower.
- Jericho attempts to build a wall to keep the Israelites out, but is unable to secure federal funding and public support. Israel walks right through the city without killing anyone.
- Jael, Heber's wife, picks up a tent peg and a hammer and helps stake down the family tent while he sleeps—Proverbs 31 woman right there!
- The shepherd boy David defeats the Philistine Goliath in a casual 5K Fun Run to combat leprosy.
- After being taunted by 42 dangerous youths, Elisha surprises the gang of rowdy ne'er-do-wells with two big bear hugs.
- Job is tested by Satan with first-world problems like his iPhone X cracking after an unfortunate drop and Starbucks being sold out of his favorite beverage after waiting in a long drive-thru line.
- In the imprecatory Psalms, the Psalmist prays that the Lord would metaphorically bash the skulls of his enemies with His love and kindness.
- Nebuchadnezzar totally roasts Shadrach, Meshach, and Abednego with a fiery Facebook rant, only for an anonymous fourth commenter to come to their defense with some savage memes.
- When He's about 33 years old, Jesus establishes a large megachurch at Calvary, has a successful, uplifting ministry, and eventually retires to the Sea of Galilee on his attractive 401K plan.
- Ananias and Sapphira donate part of their allotted offering to the church, and the Apostle Peter asks them to stand and be recognized for their generous donation.
- Just before it's about to start, the Battle of Armageddon is canceled. Jesus rolls up on a Segway in order to pass out participation trophies to everyone. Great job, guys!
What great stories from the Bible, only slightly altered for maximum warmth and fuzziness! The Violence-Free Version of the Bible is available today.
Go on now, get yourself one…
What Are You Thankful For?
If you said 'Jim West', then if you're really thankful for me, you'll buy the commentary. But if you lied, you love Satan, and you won't. #trueFact.
It's My Turn to Organize the Biblical Studies Carnival…
Going live on 1 December, just a few weeks from today, the official Biblical Studies Carnival. Which means, naturally, that posts from the month of November will be the source of joy.
So, if you see anything this month that you deem worthy of inclusion, send it along. And this month, besides blogposts and the like, I'm going for a true 'Biblical Studies' Carnival, which means that news stories, blog posts, and other sources of biblical joy will be included.
In other words, if it's biblical studies related stuff, let me know about it. (And yes, naturally SBL will be included too).
Calvin is Significant, Sure, But Zwingli is Moreso
Einigen Kirchenhistorikern gilt Calvin als "Vollender der Reformation". Auf ihn berufen sich heute mehr als 80 Millionen reformierte Christen weltweit – neben den Lutheranern der zweite große Zweig im Protestantismus. Calvin kam am 10. Juli 1509 rund 100 Kilometer von Paris entfernt in Noyon zur Welt – acht Jahre vor dem legendären Thesenanschlag Martin Luthers (1483-1546) gegen die Missstände seiner Kirche. Der "französische Luther" starb am 27. Mai 1564, im Alter von nur 54 Jahren, in Genf.
Sad News: The Death of Richard Coggins
The SOTS Secretary writes
I have learned today (via Paul Joyce) of the death on Saturday 18th November of the Revd Richard Coggins, who was President of our Society in 1993. His daughter, Sarah Fielding, indicates that it was a peaceful passing. If I receive information about funeral arrangements or obituary notices I will send out a further message. May he RIP.


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I was planning on having a quietish year this year, and I didn't take every travel opportunity I was offered for that reason. But I did still go a few places. Some I loved, some I hated, some I barely saw beyond the inside of my hotel room. (more…)
A Tour Of New Orleans' Most Famous Graveyard
Well, I couldn't leave New Orleans without visiting the grave of Voodoo queen Marie Laveau, could I?
St. Louis No. 1 is the most famous graveyard in New Orleans, probably because she's buried there. Nick Cage, despite still being alive, also has a grave there. Apparently he bought it after he visited a local voodoo practitioner for help with some life problems, and she told him he'd been cursed and would need to buy a plot in order for the curse to be lifted. (more…)
Pretty Houses Of New Orleans
I went to New Orleans for work a few weeks ago, and to my great surprise I didn't like it at all. However there were lots of beautiful buildings, so even though I wasn't having a good time I at least got to look at some pretty houses and take some nice pictures while I was there. (more…)
Providence, RI
"Where are you going next?"
"Providence, Rhode Island."
With one exception, every person I said that to made a face that meant 'ew, why would you want to go there?'
So I wasn't expecting to like Providence, which was fine because I wasn't planning to explore it. I'd be arriving late Saturday night and going straight to bed, then working until I got into a cab to go back to the airport on Wednesday afternoon. Work was a conference, and I was staying in the conference hotel, so I'd planned to just spend the whole time in that single building. (more…)
Help Me Please I Need Your Tips
I'm cheating a bit with this post, because rather than giving you tips, I'm asking for them.
Help? (more…)
You know what else Brussels does well? Everything.
Part one here, in which I discuss Brussels' excellent shopping options.
But it's not just shops that make Brussels a fantastic place to visit. It's… well, everything.
Sometimes you're just not feeling it, and that's OK
It can be weird, as a blogger, to do… well, anything. It's easy to think that you have to be 100% 'on' all the time, so you can remember not to miss anything you might want to write about later.
And trust me, this is even the case if you have a reeeaalllyy tiny reader base *waves at readers*


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Grand Targhee Resort
3300 Ski Hill Rd, Alta, WY 83414
Cycles Devinci is partnering Habitat with for a demo Saturday August 27th at Grand Targhee. We'll be there from 10am to 4pm (last bike out at 3). Stop by and demo a Troy, Spartan, Hendrix or the new Django and Carbon Wilson. Please bring pedals, helmet, riding gear and an ID. We will need you to fill out a waiver (participants under 18 will need a parents signature) and then it will take us about ten minutes to properly set up the bike for you. Then you can take the bikes out for up to an hour. Please be conscious of time so that everyone can get a chance to ride. See you there!


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_____Mark your calendar for the second annual American Extreme Enduro - News Release
Sequatchie, TN (December 13, 2011) - The first ever KENDA Tennessee Knockout, fueled by Monster Energy took place last summer to rave reviews from riders and fans. So the team at the Trials Training Center is excited to confirm that the event will be back for 2012 on September 1st and 2nd during the Labor Day holiday weekend. If you want to compete in or see a true "American Extreme Enduro", mark your calendar now. Mike Brown, the 2011 winner stated that the multi round event "Was tougher than anything I have ever done. At the halfway mark, I thought I would not be able to finish but I was leading so I kept pushing".
The top off-road racers from around the world will be invited to compete and amateur riders can race on Saturday with the top finishers earning the opportunity to move on to the Sunday Expert Knockout rounds. On Sunday, the riders will compete in a very tough and spectator friendly four round format.
Here is a peak at some of the action from the 2011 event: http://www.youtube.com/watch?v=iB6461AFVHk
For more information about the 2011 Kenda Tennessee Knockout, fueled by Monster Energy, please visit: http://tennesseeknockoutenduro.com/


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With a message about confronting one's past and facing one's fears, the author will discuss her compelling memoir and share life anecdotes. Walls' story of triumph – chronicled in her book that spent more than six years on The New York Times bestseller list, selling 4.5 million copies – makes audiences resonate with a positive attitude toward the "demons" in their own lives and a belief that anything is possible.
"Moving because it's unsentimental… Walls' journalistic bare-bones style makes for a chilling, wrenching, incredible testimony of childhood neglect. A pull-yourself-up-by-the- bootstraps, thoroughly American story."
– Kirkus Reviews
Sponsored by Roy & Jane Gersten, New Times
Co-presented with the Foundation for San Luis Obispo County Public Libraries
Meet the author at an exclusive VIP Reception from 1:30 to 2:30 pm on February 21, just prior to the talk. Food and wine will be provided and all proceeds from the $25 ticket will go to support the work of the Library Foundation.When purchasing your ticket for the talk online or at the box office, you will have the option of adding the VIP Reception to your purchase. Thank you for your support!
All proceeds benefit the
Foundation for San Luis Obispo County Public Libraries.
Purchase Your Tickets Here
To Receive a 10% discount use Code: CASTLE
Make an online purchase at www.bn.com and enter the Bookfair ID # 11812229 at checkout and Barnes & Noble will donate a percentage of your purchase to the Library Foundation.
Photos from February 21 Event:


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Video Description
Given the variability around the product manager role, it's common for product managers to start by adopting "best practices" from well-known technology companies. But these "best practices" won't work for every organization and can encourage an incurious mindset with unrealistic expectations. In this video segment, we talk about how to bring in the best of "best practices" for our specific organizational context.
Table of Contents
Product Information
- Title: The worst thing about best practices
- Author(s):
- Release date: June 2018
- Publisher(s): O'Reilly Media, Inc.


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Enhanced by its subtle elegance, this fitted black T-shirt is the perfect embodiment of this season's trends. It's fitted, made from a blend of two black jersey fabrics, and features a crew neck and three quarter-length sleeves. The tulle yoke subtly reveals your shoulders, giving the item a refined sensual touch. You can wear this sporty T-shirt with a printed skirt, velvet jacket and pair of boots for an everyday outfit.The model Lena measures 5.41ft and is wearing a size 1.
Hand wash 40
Do not bleach
Do not tumble dry
Iron at max 110
Dry clean with normal solvents
Exterior : 67% Lyocell, 33% Cotton
Yoke : 100% Polyester


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The Local's List Party 2018 Presented by Physicians Premier Emergency Room
The locals have voted on their favorites, from steak and seafood, to day spa and shopping, to music and margaritas. Make an appearance alongside category winners, and meet those that are behind everything we love about the Coastal Bend.
Join The Bend Magazine on Thursday, July 26th from 6:30 pm - 10:30 pm at the Art Museum of South Texas to celebrate everything we love about the Coastal Bend, all in one place. Sample savory cuisine from the local's favorite restaurants, sip creative cocktails and locally brewed ale, and mix and mingle with Local's List winners. There will be a live DJ set from DJ JELLOxSHOT of Hybrid Records, a fashion show, and other fun activities and demonstrations throughout the night you won't want to miss! At this year's event, each ticket purchased will allow you a punch card for drinks. You will be handed the punch card upon arrival at the event. Each card will allow you to sample 6 alcoholic beverages from a variety of vendors of your choosing. This is to ensure each guest has the ability to taste samples from each vendor. There will also be cash bars at the event. Dress Code is Cocktail Chic! -Stay tuned for a list of all the Local's List Winners you can expect to see at the party! **This event is for ages 21 and up. A valid ID must be presented at the door.
Date & Time
July 26, 2018
Art Museum of South Texas 1902 N Shoreline Blvd Corpus Christi 78401 TX US http://www.thebendmag.com/businesses/tx-corpus-christi-art-museum-of-south-texas
More Info


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Summary In this design the landing gear is driven by a 12 kg/cm servo. There is also a sonar placed looking down for automatic landing or other purposes you may find interesting. If you have suggestions on the design, please comment and I can adapt it to your idea. For the moment I am stuck with ideas on this design and I will start another soon. I made it so everything can be printed without support and still obtain decent quality. The main body should be printed with at least 30% infill in order to be strong enough. Edit1: I added the motor support and the landing leg. The bar between the legs is a fiberglass rod and is meant to flex.


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Property acquired by the Park District often is not suitable for immediate public use, due to such factors as lack of public road access, the need to eliminate unsafe conditions, the need to protect natural or man-made resources, or the need to acquire contiguous land.
Land Bank properties may be either a portion of a future East Bay Regional Parkland, or an opportunity acquisition, easement, or gift of land which has not been specifically identified as potential parkland in the Master Plan.
Such property is not opened to the public immediately, but remains in land bank status until the constraints on public access are removed.
While in land bank status, property is maintained at the minimum level necessary to protect District interests.
The process of opening land bank property for public use is specific to the unique features of that land. Generally the process takes a number of months or years, and may involve environmental assessment, a land use planning process, and infrastructure improvement. It also depends on funds available to do the required work.
Opportunities for public review and input on future parkland uses are provided as part of the land use planning process. For information on current land use plans refer to our Park Planning page.
Funding for land acquisition comes from various sources, including Measure WW and grants from non-profit, private and public sources. The timing of land acquisition does not necessarily mesh with the availability of funds for improvement and operation.When this happens, an acquisition qualifies for land bank status.


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Jennifer L. Mills-Messina, MD
- Specialty: Obstetrics and Gynecology
Crescent City Physicians701 Metairie Road
Suite 1A205
Metairie, LA 70005 Get DirectionsPhone: 504.304.7949Fax: 504.304.8589
BioDr. Jennifer Mills-Messina specializes in Obstetrics and Gynecology at Crescent City Physicians, Inc., a subsidiary of Touro Infirmary. After earning her medical degree from the University of Mississippi School of Medicine, Dr. Mills-Messina completed post graduate training at University of Alabama in Birmingham. Dr. Mills-Messina is board certified by the American Board of Obstetrics and Gynecology and treats patients at both the Uptown and Old Metairie locations. Languages SpokenEnglish
Patient Ratings and Commments
All patient satisfaction ratings and comments are submitted by actual patients and verified by a leading independent patient satisfaction company, NRC Health. Patient identities are withheld to ensure confidentiality and privacy. Only those providers whose satisfaction surveys are administered through LCMC Health are displayed. Click Here to learn more about our survey


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I seem to be on a bad streak of luck. My PSU fan is spinning too fast, it sounds like a jet engine.
I´m not too tech minded but can manage - sometimes .
It´s a mini atx power supply.
Running kubuntu 10.04.
Thanks for any help on this.
+ Reply to Thread
Results 1 to 7 of 7
psu fans are internally controlled. time for a new psu.--
"a lot of people are better dead" - prisoner KSC2-303
How much heat is coming out of the PS exhaust? If it's really hot, like a hair blow dryer, then the PS is overheating. That's bad.
It could be clogged with dust, but so would the rest of your PC. More likely it's either overloaded or getting ready to die.
If it does die, it could take the whole PC with it, along with your data. $$
Invest in a new power supply asap. If you are tech minded you can hook it up yourself, or if not you can have it done for you at a place like Best Buy, or any computer repair shop.
The air coming out of vents is normal - just spinning the hell out of the PSU .
Temperature readings are high - 100 dg and 114 dg in 10 minutes of being switched on but the PSU is cool to the touch.
Is the fan really runnng too fast or is it just making excessive noise? The maximum speed of a fan is normally determined by the oscillator circuit inside it and it would be very unusual for one to go too fast. If it is just very noisy, there *may* be a quick and free fix for it if you are willing to have a go. This is what to do:
1. Unplug the computer completely from the wall socket and leave it 5 minutes to allow parts inside the PSU to fully discharge.
2. Open the compuer and remove the PSU, normally there are up to 4 screws, accessible from the back panel. Also unplug all the cables to the drives and motherboard.
3. With the PSU removed, find the screws holding it's cover in place and remove them so you can see inside the PSU. Blow/brush out any dust that has accumulated there.
4. Look for the screws securing the fan itself, they are usually short fat ones, remove them so the fan can be lifted out of the PSU. If the fan wires are on a plug, unplug it, otherwise be careful not to tear them off the board.
5. One side of the fan will have a manufacturers label on it, carefully peel the label off, try not to tear it if possible.
6. In the center, under where the label was you should see the motor shaft, a thin steel pin. Sometimes there is a soft rubber bung over it, if there is remove it and keep it safe.
7. With the shaft visible, put ONE drop of light machine oil on it and spin the fan blades by hand a few times to work it into the bearings.
8. refit the bung if there was one, replace the label (or put a stick paper patch over the hole if the label was damaged) and reassemble in reverse order of dismantling.
I've done it many times with 100% success. what seems to happen is the lubrication in the bearings eventually dries out and the rotor starts to vibrate on the shaft, making it very noisy and eventually making it stop turning altogether. After replenishing the oil the fan should run for several years more. It's worth cleaing any dust out of the rest of the machine while you have it open, be particularly careful with the fan on the CPU and the fins below it.
I stress you should only add ONE drop of light oil. Someone I could name tried this and decided it would be quicker to simply pour oil in through the vent holes in the PSU. As you might expect, none went into the motor bearings at all but the rest of the computer was completely and permanently trashed!
Thanks Brian , I´ll give the suggestion some thought. Never really touched the hardware though.
The pc´s been in for repair lately - nearly 4 months if you can believe that .
Maybe the technician forgot to plug in a wire


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Want to know when Glentoran Fc Belfast are next playing live football on TV and on which channel?
This Glentoran Fc Belfast on TV Schedule is updated daily to make sure you know when and who they are playing on TV during the 2019/20 season across all satellite and freeview channels in the UK including Sky Sports, BT Sport, Premier Sports, BBC, ITV and on official live streams.
So, If you are trying to find out if Glentoran Fc Belfast are on TV today, tonight, tomorrow or this weekend make sure you view our Football on TV Listings for all of their upcoming live televised fixtures.
There are several ways to watch the next Glentoran Fc Belfast game on TV or online - check out our Glentoran Fc Belfast Live Stream guide.
This Glentoran Fc Belfast TV schedule was updated on 10 August 2020.


text: Pianist Shorty Allen, who also doubled about vibraphone, was energetic about the jazz picture within the '40s and '50s, but by the finish of the second option 10 years had also become somewhat mixed up in world of songwriting and song-plugging. He was associated with such makers and record label owners as Joe Davis and was mixed up in early recording profession launch of the beautiful vocalist Leslie Uggams. Allen worked well alongside some jazz greats certainly, particularly the excellent vocalist Ella Fitzgerald, who demanded a lot from her piano accompanists, and offered time alongside a Kai Winding along with a young Stan Getz when these monster jazz hornmen had been still determining what was happening in the big music group section. The previous player was section of Allen's personal Arcadia Ballroom music group, which was mixed up in past due '40s and early '50s. It had been the professional begin for trombonist Winding, who shifted to america from Denmark in 1934. Among Allen's previous gigs like a sideman was with John Benson Brooks, an arranger who got previously worked well for Les Dark brown. Brooks shaped a music group for an engagement in the Howard Theatre in Washington in 1944, that was where Allen 1st fulfilled Getz. These early recordings have already been reissued many times, due to the cult that insists every notice performed by Getz will probably be worth hearing. Allen also worked well within the Fred Norman music group with players such as for example guitarist Danny Perri and Fat Waller alumni Cedric Wallace. The crafty Davis nabbed Allen to try out vibes on an early on Leslie Uggams program in 1952, the consequence of the producer's decision to enter the children's record marketplace. These recordings of music such as for example "Percy the Pale-Faced Polar Carry," "Every Small Piggy's Got a Curly Tail," and "Palsy Walsy Property" were ultimately regarded as children's classics. When the game titles suggest something of the cultural descent through the class of Ella Fitzgerald performing Cole Porter, or winding down a path of smart harmonic substitutions, the most severe was however to arrive. By 1956, Allen was associated with quite insubstantial pop materials, including light piano music with oohing history performers, but he do score big using a tune entitled "The Rock and roll & Move Waltz." The Kay Starr cut of the record, completed for RCA, was the main tune for six weeks and it has been detailed because the 16th most widely used record from the so-called "1955-1959 rock and roll period," something of the mind-numbing statistic that's only rivaled with the song's lyrics: "There in the night time what a amazing scene./Mother was dance with Father to my record machine./And even though they danced, only 1 issue was wrong: these were looking to waltz to some rock and roll & roll track." Etc. While Allen was a lot more than happy to consider credit for the music of "The Rock and roll & Move Waltz," the party that developed the lyrics continues to be something of the secret. For the record, there's the "dick" theory, that somebody by the name of "Dick" may be the lyricist. This guy has been recognized variously as Dick Ware, Dick Smart, and Dick Wines. The misunderstandings — and it is not over however — is in fact quite typical from the posting business, even though the entire character of posting is coping with documentation concerning the titles of composers and tunes. Major publishers possess again and again demonstrated an entire failure to spell a good four-letter name correct. Addititionally there is the idea that "The Rock and roll & Move Waltz" was a cooperation between Allen and novelty pop songwriter Roy Alfred, the inventor from the "Hucklebuck," once again occasionally misidentified by web publishers as Alfred Roy. A reasonably total Alfred discography, nevertheless, fails to point out his participation with "The Rock and roll & Move Waltz," which will be quite an oversight even though it wasn't the 16th most widely used record between 1956 and 1959. It really is accurate that Alfred and Allen published songs together, discovering "Cheerleader Turn," possibly the 16th many overlooked tune in history, which really is a pity. Despite indications in any other case, the cowboy tune "Ode to some Gnarly Footed BATHTUB" was compiled by an alternative Shorty Allen, as there is no proof Ella Fitzgerald ever creating a cowboy support her through to piano. "The Rock and roll & Move Waltz" became a dance music group favorite and there have been some cover variations, like a recording with the Gedson Sisters, and a Swedish discharge, the "The Rock and roll & Move Valssi."


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- Joshua Li
Trainer Tips - What to Eat & When
Breakfast with Benny
'Breakfast is the most important meal of the day'.... I believe this to be true. Follow the rule of high protein, low carb and high healthy fats and you will be starting the day the best way possible.
The high protein element will keep you fuller longer, helping avoid any mid-morning snacking. The fats from the steak and egg yolks will provide a slow and steady rise in blood sugar level. This breakfast will increase dopamine and acetyl-choline levels, which will help improve concentration.
Pineapple and Lemon water - To help aid digestion.
Lunch with Aidan
Lunch consists of a balance of high protein, moderate healthy fats and green veggies. We keep carbs low at lunch as we are looking to place them nearer to the workout.
We have a good amount of protein from the chicken breast to keep us in an anabolic state and moderate amount of healthy fats from the avocado to provide additional energy until our next meal. Greens are a great source of fiber which will aid the digestive system. I prefer Broccoli as it makes me feel slightly fuller.
Pre-workout with Josh
The pre-workout meal should be an easily digestible meal. The last thing you want is a heavy meal in your stomach trying to go down while you train.
I simply go for protein oats for this meal. The whey is fast to digest and primes my body with an adequate amount of protein in my bloodstream, ready to be delivered to my working muscles during training. Oats are slow release carbohydrates. The carbs will help fuel my session by gradually providing energy. Stay away from high GI (sugary) carbs pre-workout as your insulin levels will spike and soon crash during the session.
Intra-workout with Lezlie
While you are training, your muscles are in a perfect position to absorb nutrients. I choose to use essential amino acids over BCAA's. BCAA's contain the amino acids (leucine, isoleucine and Valine) that prevent muscle protein breakdown, but will not increase muscle protein synthesis, unlike essential Amino acids which does exactly that.
Glycofuse is a special carbohydrate product that is absorbed in to your blood stream incredibly fast, meaning muscle glycogen can be replenished within minutes, allowing muscular recovery almost instantly. The glycofuse will also help transport the muscle building nutrients from the essential amino acids to the working muscles faster.
Post workout with Simon
A lean protein source will aid protein synthesis and be absorbed faster. Fats will slow down absorption rates of the protein, so I will avoid fattier proteins such as steak, salmon and whole eggs post workout and go for the lean meats (chicken, turkey, white fish).
To further replenish muscle I use a faster absorbing carbohydrate such as white rice. Again, post workout your muscles are still primed to absorb these carbs to replenish glycogen stores.
Dinner with Jon
For the last meal of the day, I am a big believer of high protein and high healthy fats. I will opt for a fattier protein such a Salmon Salmon which contains a good level of protein and healthy fats. When we sleep, we care going through a period of not eating for 6-8 hours... The fats from this last meal of the day will slow down the absorption rates of the protein, meaning a slower release in to the body throughout the night, which in turn will help avoid catabolism (eating away at muscle).


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For years studies have found marijuana use to increase risk of heart disease and stroke. Now a marijuana lollipop has been linked to a man's heart attack.
Treating his arthritis and insomnia, an 70-year old man licked a marijuana lollipop and within a half hour experienced crushing chest pain. The lollipop contained 90 mcg of THC, which is multiple times more potent than an average joint, according to Fox News.
They report he experienced hallucinations and anxiety which led to a spike in his heart rate and blood pressure thereby stressing the heart. Fortunately he survived.
The lollipop was not intended to be a single use edible but many find it unsanitary to lick a few times and save for later.
Many studies have linked marijuana use to heart attacks, heart failure and stroke.
In 2017, Dr. Aditi Kalla and colleagues from Einstein Medical Center in Philadelphia analyzed 20 million health records of patients who were hospitalized in 2009 and 2010 and found those who used marijuana (1.5% of the patients studied) were at high risk of coronary artery disease, sudden cardiac death, heart failure and stroke.
What's even more striking is the patients were younger, aged 18-55. Risk factors including obesity, high blood pressure, alcohol use and smoking were already taken into account.
One theory for the link between heart disease/stroke and marijuana use is that cannabis may affect the cardiac muscle cell's ability to contract, affecting the pumping mechanism of the heart, thereby leading to heart failure. Another theory is marijuana, like cigarette smoking, may be increasing risk of clots. Below is a report on a study linking marijuana use to Transient Ventricular Regional Ballooning (TVRB). This can also lead to heart failure. Another theory suggests cannabis causes a release of stress hormones, such as cortisol.
In 2016 study out of St. Luke's University Hospital Network found marijuana to cause stress cardiomyopathy. This is a temporary condition that causes a "ballooning" of a region of the ventricle known as Transient Ventricular Regional Ballooning (TVRB). We know that many drugs can cause cardiomyopathy (affect the heart muscle) such as cocaine and stimulants causing dilated cardiomyopathy, but this is new in that a sedating type of drug such as cannabis/marijuana, can cause similar effects on the heart.
The condition of TVRB can mimic many different heart conditions because it presents with chest pain, shortness of breath and dizziness. So many individuals admitted for these symptoms are evaluated for a heart attack, angina, pneumonia, and a variety of other diagnoses.
In this study, the researchers looked at data from 33,000 hospital admissions who had TVRB and saw a link between 210 of these admissions and marijuana use. They are unsure how marijuana affects the heart, but theorize that it could be an increase in cortisol and stress hormones. Although none of the marijuana users in this study died, the TVRB can cause cardiac arrest, heart attack.
History of Lollipops
For centuries civilizations had found ways to satisfy our sweet tooth. Ancient Egyptians would mix nuts, fruit and herbs into a ball that could be skewered with a stick. Putting candy on a stick was common as it allowed a sticky sugary or carmelized treat to be eaten easily.
However the modern style lollipop we believe was invented by George Smith of New Haven, CT in 1908.
The name "Lollipop" was trademarked in 1931 after he reportedly named the candy after a popular race horse, "Lolly Pop."
Learning Medical Spanish is Easy!!!
Daliah Wachs, MD, FAAFP is a nationally syndicated radio personality on GCN Network, KDWN, and iHeart Radio.


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Canon PIXMA TS8140 Driver Download, Review and User Manual Setup for Windows, Mac OS, and Linux - The Canon Pixma TS8140 is a three-in-one printer, scanner, and photocopier that utilizes inkjet technology to provide the six ink colors that the printer could fit. It could also print electronically from a smart device via Bluetooth and Wi-Fi. Small but mighty with attractive square designing, this six solitary ink All-In-One offers wise wireless and cloud connectivity and an auto-tilt panel with 10.8 cm touchscreen - so you can develop fantastic photos and crisp text files in seconds. From these devices, the Canon Pixma TS8140 can likewise check. With the capability to print documents along with pictures, this printer is one that appropriates for usage in your home. It is also easy to operate which makes it suitable for any family members. Attach conveniently to smart tools via a variety of alternatives including Bluetooth for easy Wi-Fi print and scan utilizing the Canon PRINT app.
The streamlined layout of the Canon TS8140 makes it a necessary addition to a home office and guarantees that it is easy to position where needed. It has measurements of 372 x 324 x 139 mm without the cover being open or the trays being withdrawn. The feeder trays can be taken out, when needed, to support 20 sheets of photo paper and 100 sheets of pure writing. It has a 10.8 cm touchscreen on the pivoted front panel and includes a USB port and memory card ports. Print perfectly rich borderless 4x6" images in 17 seconds thanks to cutting-edge technology and six original inks, that include a new Photo Blue for more exquisite detail. Experience the freedom of cloud printing and scanning right from the printer. It takes seconds with PIXMA Cloud link accessed using the printer screen or Canon PRINT app.
The Pixma TS8140 is easy to use and presents the appropriate text and icons which can be utilized to regulate all the attributes. It allows for publishing using some approaches and can be made use of with the Canon PRINT app to benefit from the Cloud Link to check and print wirelessly. It takes only 17 secs to write a borderless 10 x 15 centimeters photo, and it has auto two-sided printing capacities. Every one of these attributes makes it the excellent printer for your home office. Enjoy easy smartphone-like control utilizing a big 10.8 centimeters touch display on an auto-tilting front panel. The Interface mirrors the Canon PRINT app for a seamless experience. Only change the color you require with specific inks and deal with both photo and paper media with dual feeders. Conserve with XL or XXL container options and auto 2-sided printing.
Also, recommend: Canon PIXMA TS8053 Driver and Manual Download
Canon PIXMA TS8140 Specifications:
- Printer Specifications
- Print Resolution: Up to 4800 1 x 1200 dpi.
- Print Technology: 6 Individual Ink Tanks (PGBK, BK, C, M, Y, PB), ChromaLife100 inks.
- Mono Print Speed: Approx. 15.0 ipm.
- Colour Print Speed: Approx. 10.0 ipm.
- Photo Print Speed: Borderless 10x15 cm: Approx. 17 seconds.
- Borderless Printing: Yes (A4, Letter, 20x25 cm, 13x18 cm, 10x15 cm, 13x13 cm).
- Two-Sided Printing: Auto Duplex Print (A4, A5, B5, Letter - Plain Paper).
- Direct Disc Printing: Yes (software included).
- Cartridges And Yields
- Standard Ink Cartridges: 6 individual ink tanks, PGI-480PGBK (Pigment Black), CLI-481BK (Black), CLI-481C (Cyan), CLI-481M (Magenta), CLI-481Y (Yellow), CLI-481PB (Photo Blue).
- Optional XL Ink Cartridges: High yield XL ink tanks, PGI-480PGBK XL (Pigment Black), CLI-481BK XL (Black), LI-481C XL (Cyan), CLI-481M XL (Magenta), CLI-481Y XL (Yellow), CLI-481PB XL (Photo Blue).
- Optional XXL Ink Cartridges: High yield XXL ink tanksl, PGI-480PGBK XXL (Pigment Black), CLI-481BK XXL (Black), CLI-481C XXL (Cyan), CLI-481M XXL (Magenta), CLI-481Y XXL (Yellow), CLI-481PB XXL (Photo Blue).
- Ink Tanks Yield (Plain paper): A4 Colour Document 5, Pigment Black: 200 pages, Pigment Black XL: 400 pages, Pigment Black XXL: 600 pages, Black: 750* pages, Black XL: 2280* pages, Black XXL: 4590* pages, Cyan: 259 pages, Cyan XL: 519 pages, Cyan XXL: 830 pages, Magenta: 223 pages, Magenta XL: 466 pages, Magenta XXL: 747 pages, Yellow: 259 pages, Yellow XL: 519 pages, Yellow XXL: 830 pages, Photo Blue: 1660* pages, Photo Blue XL: 4710* pages, Photo Blue XXL: 9140* pages, Estimated supplemental yield.
- Ink Tanks Yield (Photo print): 10x15 cm photo, Pigment Black: 1562* photos, Pigment Black XL: 4758* photos, Pigment Black XXL: 7382* photos, Black: 212* photos, Black XL: 501* photos, Black XXL: 795* photos, Cyan: 80 photos, Cyan XL: 187 photos, Cyan XXL: 296 photos, Magenta: 107 photos, Magenta XL: 256 photos, Magenta XXL: 397 photos, Yellow: 80 photos, Yellow XL: 187 photos, Yellow XXL: 296 photos, Photo Blue: 241 photos, Photo Blue XL: 501 photos, Photo Blue XXL: 788 photos, stimated supplemental yield.
- Paper Support
- Paper Types: Plain Paper, Canon High Resolution Paper (HR-101N), Canon Pro Platinum (PT-101), Canon Plus Glossy II (PP-201), Canon Pro Luster (LU-101), Canon Plus Semi-gloss (SG-201), Canon "Everyday Use" (GP-501), Canon Matte (MP-101), Envelopes, Other Fine Art Papers, Printable Discs.
- Maximum Paper Input: Rear Tray: Max. 20 sheets (photo paper) or Max. 100 sheets (plain paper), Front Cassette: Max. 100 sheets (plain paper), Direct Disc Print Tray: 1 printable CD, DVD or Blu-Ray Disc.
- Paper Sizes: Rear Tray: A4/A5/B5/LTR/LGL/20x25cm/13x18cm/10x15cm/13x13, Envelopes(DL,COM10), Front Cassette: A4, A5, B5, LTR.
- Paper Weight: Rear Tray: Plain paper 64 - 105 g/m², Canon photo paper up to 300 g/m², Front Cassette: Plain Paper: 64-105 g/m2.
- Scanner Specifications
- Scanner Type: CIS flatbed photo and document scanner.
- Scanner Resolution (Optical): 2400 x 4800 dpi.
- A4 Scan Speed: Approx. 14 sec.
- Scanning Depth (Input / Output): Colour: RGB each 16 bit/8 bit, Greyscale: 16 bit / 8 bit.
- Maximum Document Size: 216 x 297 mm.
- Copier Specifications
- Copy Speed: sFCOT: Approx. 19 sec, sESAT: Approx. 6.5 ipm.
- Multiple Copy: 99 copies max.
- Copy Functions: Document Copying, Photo Copying, Borderless copy, 2-sided copy, 2-on-1 and 4-on-1 copy, Frame erase copy, Disc Label Copy, ID copy.
- Copy Zoom: 25 - 400% (in 1% increments), Fit to page, A5 to A4, B5 to A4, A4 to A5 and A4 to B5.
- Interface
- Display Type & Size: 10.8 cm LCD (TFT colour/Touch).
- Interface Type - PC / Mac: Hi-Speed USB (B Port), Wi-Fi: IEEE802.11 b/g/n, Wi-Fi Security: WPA-PSK, WPA2-PSK, WEP, Administration password, Wireless LAN Frequency Band: 2.4GHz.
- Interface Type - Other: Bluetooth Low Energy (BLE), Message In Print app, PIXMA Cloud Link, Canon PRINT Inkjet/SELPHY app, Canon Print Service Plugin (Android), Google Cloud Print, Apple AirPrint, Wireless Direct, Access Point Mode, WLAN PictBridge, Memory Card Slot, Mopria (Android).
- Compatible Memory Cards: SD Card, SDHC Card, SDXC Card, miniSD Card*, micro SD Card, mini SDHC Card*, micro SDHC Card*, microSDXC Card, Using recommended adapter - not supplied.
- Software
- Supported Operating Systems: Windows 10 , Windows 8.1, Windows 7 SP1, Note: For Windows, .NET Framework 4.5.2 or 4.6 is required, OS X 10.10.5~OS X 10.11,macOS 10.12.
- Supported Mobile Systems: iOS, Android, Windows 10 Mobile.
- Minimum System Requirements: Windows: 3.1 GB disk space, Internet Explorer, Mac: Internet connection, 1.5GB disk space, Safari, Display: 1024 x 768 XGA.
- Software Included: MP Driver including Scanning Utility, My Image Garden with Full HD Movie Print, Quick Menu, Easy-WebPrint EX (download).
- Physical Features
- Weight: approx. 6.5 kg.
- Dimensions (W x D x H): approx. 372 x 324 x 139 mm.
- Acoustic Noise Levels: approx. 48 dB(A).
- Recommended Operating Environment: Temperature: 15-30°C, Humidity: 10-80%RH (no dew condensation).
- Power Source: AC 100-240 V, 50/60 Hz.
Canon PIXMA TS8140 Operating System Compatibility:
- Windows 10
- Windows 8
- Windows RT
- Windows 7, Windows 7 SP1
- Windows Vista SP1, Vista SP2
- Windows XP SP3 32-bit
- Mac OS X v10.3.9 to 10.5, Mac OS 10.7(Sierra) or later
- Linux
Instructions to Setup or Install Canon PIXMA TS8140 Driver:
- When the download has completed, open the file where the file was downloaded. Then click on file.
- You can accept the default area for storing data. Click Next, and then wait while the installer pulls out the data to get ready for installment on your computer.
- When the installation process is complete, the computer restarts your computer system.
- Then test for examinations as well as print check review.
Instructions to Uninstall Canon PIXMA TS8140 Driver:
- In the Start Menu on your computer opens control panel.
- In Control Panel menu chooses to Uninstall a Program.
- When Uninstall a Program has opened, you can select the driver that you want to uninstall.
- After an uninstalling process is complete, restart your computer to make computer working normally again.
Canon PIXMA TS8140 Driver and User Manual Download
Operating System
|TS8140 series Full Driver & Software Package (Windows)
|TS8140 series Full Driver & Software Package (Mac)
|TS8140 series XPS Printer Driver Ver.6.10 (Windows)
|TS8140 series MP Drivers Ver.1.00 (Windows)
|TS8140 series Getting Started Guide
|TS8140 series (PDF) User Manual (Mac)
|TS8140 series (PDF) User Manual (Windows)


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Page One
Learn S.F. lessons
The situation in San Francisco where the school district, wasted, and lost millions of taxpayer dollars through poor planning, mismanagement, and perhaps fraud should be a lesson to all school districts, including the Berkeley School District, The errors of SF include, a go-along board that never looked into the details, that only read the summary sheet, that never asked hard questions, that failed to implement the advice from consultants; and, ignored its own citizen advisory committees. This pattern is one that exists in Berkeley as well.
It was extremely disappointing to hear School Board member Rivera state at last Wednesday's school board meeting that he appreciates the fact that school staff is only giving the Board a summary of what is going on with Measure BB monies and in maintenance and just a few examples of the supporting data.
I hear lots of talk about accountability. Accountability is based upon facts. The citizens of Berkeley have asked that school district information be made public, and deposited with the Reference Desk of the Public Library, Central Branch. The question for the Board is how can you carry out your fiduciary duty to the citizens if you don't want the facts? As the saying goes, the devil's in the details.
Yolanda Huang
Chair, Maintenance Oversight & Planning Committee, Berkeley


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Emazing Bicycle's New Selene 73h3r
Affordable Power
Emazing Bicycle Corporation was founded in 2011. The idea of "Emazing Bikes" sprouted when the founders got together years ago talking about how today's transportation impacted the environment. In 2009, they realized a revolutionary solution by creating eco- and user-friendly electric bikes – the Emazing Bicycles. Emazing Bicycle Corp has currently nine bikes to choose from $1400-$2000. For mor more information check out www.emazingbike.com . Here's one of their popular bikes.
Selene 73h3r
- Total 46 lbs Step-through Electric Bicycle
- 700Cx38 wheel with all frame meet ISO4210 – Safety requirements for e-bike
- 7-speed Shimano derailleur; Maxxis tires with nighttime reflection
- 36V/8.7AH Panasonic NNP Li-ion Battery (same as the one used for Electric Vehicle in USA) with advanced Battery Management System, and complied with UN38.3 test required by Federal Aviation Administration; it's pretty safety for ebike power
- Taiwan Hodaka (supply aluminum to iPhone) 350W DC rear brushless gear motor
- 5 smooth PAS riding options; 20 MPH top speed
- USA patented Peadal Assist System by cadence feed-forward and Dutch torque sensor feed back control make riding very smoothly and comfortably; really it's high-tech automation in Selene electric bicycle
- Front and rear disc brakes
- Multi-functional J-LCD operating panel
- French designed sturdy double layer fenders installed
- Rack and light-weight fork suspension equipped
- Lock provided
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text: Digital microfluidics, in which individual droplets are manipulated on an array of electrodes, is currently limited to a single horizontal plane. That circumstance restricts the number of samples that such microfluidic devices can handle and makes it difficult to integrate multiple physical and chemical environments on the same device. Aaron Wheeler and coworkers at the University of Toronto now describe a novel method for droplet manipulation—all-terrain droplet actuation (ATDA)—that works on a variety of device shapes (Lab Chip, DOI: 10.1039/b801516c). The researchers constructed arrays of copper electrodes on flexible polyimide substrates that can be bent into staircases, twists, and even upside-down architectures (shown). Their model shows that droplets smaller than 7.3 µL can be driven up a 90º incline; larger droplets are restricted to smaller angles. Wheeler and coworkers used ATDA to cycle droplets on oxygen- and temperature-sensitive sensors. They also have developed a device that concentrates oligonucleotides from a solution containing histone proteins. The researchers suggest that ATDA will be useful for other sample enrichment techniques and applications such as DNA amplification that require samples and reagents to be cycled between different reaction conditions.


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As an overall guideline, spending a bit more for quality pants goes a very long way towards longevity. The absolute most versatile pants aren't insulated, as they permit you to personalize your system based on the temps. Pants which are too large can bring about mobility issues-consider snow pants with a safe closure system and elastic waist. This kind of snow pants is usually called shell pants. Arguably the most flexible snow pants are the ones which fall into both layer uninsulated pants category.
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Based on Kim Barker's memoir, "The Taliban Shuffle," "Whiskey Tango Foxtrot" contains the fondly, proudly recalled details of battle-tested experience. Kim — last name "Baker" in the film — goes from typing TV news in an office to a tour of duty as a journalist in war-ravaged Afghanistan. She dashes into a shootout to get video, parries the clumsy advances of an Afghan government official and frequents the hormone-addled expat party scene.
[ Read an interview with Tina Fey ]
Somewhere along the way, she also finds herself and cracks a few jokes. That's not entirely unexpected, because Kim is played by Tina Fey, an old hand at portraying the self-deprecating, nerdy workaholic getting a handle on her personal life. Directed by Glenn Ficarra and John Requa, "Whiskey Tango Foxtrot" suggests a serious extension of Ms. Fey's best-known comedic persona, on more treacherous terrain and with an Afghan culture clash. Instead of walking the absurdist halls of "30 Rock," Ms. Fey's character is sucked into the grueling but addictive pursuit of war journalism.
Kim embeds with the military to chase stories, half-reluctantly hooks up with a foul-mouthed British journalist (Martin Freeman) and generally gets her groove back. Bouncing on and offscreen like recurring TV characters are her protective, traditional-minded young fixer, Fahim (Christopher Abbott); her frenemy news colleague Tanya (Margot Robbie); and that goofily forward government official (Alfred Molina).
As written by the TV veteran Robert Carlock, Kim's rise-and-fade arc is sympathetically rendered, with humor and the urgency of an underhand pitch. The frazzled editing of Kim's arrival in Kabul as a naïf subsides early, replaced by a narrative glide that hints self-knowledge will emerge from the chaos. Kim's achievements are swiftly packaged as personal wins, such as when she proves her savvy to a top Marine officer (Billy Bob Thornton) she's reporting on.
To an extent, the film's shortfalls feel bound up with high expectations for Ms. Fey. As Kim, she wants to show how the risky search for scoops in Kabul feeds something within her without really sustaining her. But somehow the effort translates into this talented performer holding back a little too much, losing the expressive verve that firing on all pistons as a comic seems to give her. It also doesn't help that Ms. Fey's sharpest past work has simultaneously skewered the archetype of the neurotic single professional and complicated it with a self-conscious edge that this film could use.
That's not to judge "Whiskey Tango Foxtrot" (the title is a play on a common profane phrase using the military phonetic alphabet) by its star's previous successes. (The Afghan setting streamlines the book; Ms. Barker, now an investigative reporter for The New York Times, also went to Pakistan.) But the film's directors aren't as sure-footed as they were with the manias of "I Love You Phillip Morris." The Afghan portrayals bend between affectionate understanding and cheap shots.
Some of the film's shorthand reflects the cut-to-the-chase caricature of someone forced to adapt to frequently hostile surroundings (in which Kim is harassed as an independent woman in the streets). But the film also rests in a tidiness that's at odds with the messiness of the milieu. And even when we are exposed to glimpses of wartime violence and menace, it's undercut by fuzzy platitudes near the end of the film. Ms. Barker seems to have earned the reward of such a reassuring conclusion, but it's not clear the movie has.
"Whiskey Tango Foxtrot" is rated R (Under 17 requires accompanying parent or adult guardian) for language, sexual content, drug use and images of war. Running time: 1 hour 52 minutes.


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Enjoy! Milford Oyster Festival
August 4, 2015
They've been called "Nature's Most Helpful Mollusk"--which snails probably resent. On top of the fact that an oyster contains 16 grams of protein and a host of nutrients like zinc and calcium, it's also delicious. And few Americans appreciate oysters quite as much as Connecticut dwellers!
On August 15, take a scenic 45 minute drive from Norwalk to Milford, and enjoy a day of entertainment and delicious oysters all day at the Milford Oyster Festival. Oh, and did we mention the free admission? Here's how you can get the most out of your day (or two).
Arrive Early
The night before the Oyster Festival, there's a pre-festival tradition called Oyster Eve. It starts at 6:00pm and goes until 10:00pm on Friday, August 14. Head to the Downtown Shops and Lisman Landing to kick the weekend off, then stay the night at a local hotel.
If you'd prefer to leave on Saturday, head out early--there's sure to be some traffic on the way there. Enjoy the cool morning breeze as you take the scenic seaside route through Fairfield, Bridgeport, and into Milford. If you'd rather take public transportation, you can; it just takes a little bit longer to reach your destination.
Note: the Milford Oyster Festival officially starts at 10am and goes until 6pm!
Be there or be square.
Be Prepared
How often do we find ourselves without sunscreen, water, or cash for an all-day event? Make sure you take the aforementioned items, and before you head out, check the weather. Chance of rain? Bring ponchos or an umbrella (this festival's happening rain or shine). If you're carrying a purse or wallet, make sure it's not heavy and doesn't have to be held at all times (you'll lose it). Ensure you're wearing proper shoes, and if it's sunny, wear a hat. Hair gets flat anyway, sunscreen wears off, and the last thing you want is a bad face burn before work Monday.
If you're planning on carpooling with friends, make sure you ask right away! After all, friends don't let friends miss one of the best seafood festivals in Connecticut.
Plan Ahead
If you're planning on joining the Oyster Shucking Contest, you'll need to be there by 12:15, when the first heat begins. If you're excited to see Gin Blossoms, FastBall or The Rembrandts, better plan on being in the right place at the right time! Check the main stage schedule for details on musical acts.
The main stage and oysters aren't the only things happening--there's a car show, harbor stage, and harbor activities. Dive into your favorites --check out individual schedules under "Entertainment Schedules" on the main page.
Bottom line? You'll get more out of your day if you plan ahead. If you'd rather just wander and see what happens, that's OK, too. Stress-free is best.
Can't make it this year? Have no fear--you can snag delicious seafood in Norwalk, CT anytime. If you're looking for the best luxury apartments for rent in Norwalk, what are you waiting for? You'll be close to all the Norwalk action, but just far enough to relax and recharge in your luxury home. Get in touch with us today and we'll answer your questions.
Image: Milton Oyster Fest 2013


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Heyday's 40th Anniversary Celebration
Saturday, November 1, 2014 from 6:30 PM to 10:00 PM (PDT)
Event Details
Heyday plays a unique role in California, celebrating Native cultural revival, promoting boundary-breaking ideas in history, environment, and the arts, and doing so with integrity, generosity, and grace. Join us as we celebrate Heyday's past, discuss its future, and honor its founder and publisher, Malcolm Margolin.
Heyday's 40th Anniversary Celebration: The Heyday of Malcolm Margolin
Saturday, November 1, 2014 at 6:30 p.m.
UC Berkeley Art Museum and Pacific Film Archive
2626 Bancroft Way, Berkeley, CA 94720
6:30 p.m. – Cocktails, food, live music, and silent auction
8:00 p.m. – Program and live auction
Maxine Hong Kingston, award-winning author
Mark Buell, special guest auctioneer
Malcolm Margolin, Heyday founder and publisher
$175 per person
For more information, please contact Lillian Fleer at
(510) 549-3564, ext. 316 or firstname.lastname@example.com.
BOARD OF DIRECTORS: Guy Lampard, Chairman; Richard D. Baum; Barbara Boucke; Steve Costa; Nik Dehejia; Lokelani Devone; Theresa Harlan; Nettie Hoge; Marty Krasney; Michael McCone, Chairman Emeritus; Alexandra Rome; Sonia Torres; Michael Traynor; Lisa Van Cleef, Vice Chair; and Patricia Wakida.
HOST COMMITTEE: Peter Coyote, Lauren and Alan Dachs, Frances Dinkelspiel, Charles and Jamy Faulhaber, Lori Fogarty, Anthea M. Hartig, Charlene Harvey and Michael McCone, Robert Hass and Brenda Hillman, Huey Johnson, Tom Killion, Thomas C. Layton, David Mas and Marcy Masumoto, Susan Medak, Claire Peeps, Ishmael Reed, Hon. Nancy Skinner, Rebecca Solnit, Mike Sweeney, Alice Waters, and Al Young.
Many thanks to our generous sponsors!
Mr. and Mrs. Paul Bancroft ~ Charlene Harvey and Michael McCone ~ Lauren and Alan Dachs ~ Chris Desser and Kirk Marckwald ~ Guy Lampard and Suzanne Badenhoop ~ Yoche Dehe Wintun Nation ~ Yosemite Conservancy ~ Berkeleyside ~ Graham Chisholm ~ Jon Christensen ~ Coke and James Hallowell ~ Restore Hetchy Hetchy ~ Ernest and June Siva ~ Advocates for Indigenous California Language Survival ~ Judy Avery ~ California State Parks Foundation ~ Nik Dehejia ~ Patrick Golden ~ Theresa Harlan and Ken Tiger ~ Carla Hills and Frank LaPena ~ Claudia Jurmain ~ Richard Nagler ~ Bay Nature ~ Mike Bergstrom and Beth Pratt ~ John and Nancy Cassidy ~ Patricia A Dixon ~ East Bay Regional Park District ~ Stephen Edelman ~ Charles and Jamy Faulhaber ~ Barry and Erica Goode ~ Cindy and David Heitzman ~ Linda Maio and Rob Browning ~ Point Reyes Books ~ Jim Quay ~ Charity V. Romero ~ The Bancroft Library ~ The Book Club of California ~ Thomson-Shore ~ David Wilson ~ Ralph Benson ~ California Wildlife Foundation ~ David F. Chu ~ Lucille Lang Day ~ Cricket Halsey ~ Donna Huggins ~ Jesse Flyingcloud Pope Foundation ~ Thomas C. Layton ~ Pam Mendelsohn ~ Northern California Independent Booksellers Association ~ Robyn G. Peterson ~ Bonnie Portnoy ~ Craig Strang
When & Where
UC Berkeley Art Museum and Pacific Film Archive
2626 Bancroft Way
Saturday, November 1, 2014 from 6:30 PM to 10:00 PM (PDT)
Add to my calendar
Heyday is an independent, nonprofit publisher founded in 1974 in Berkeley, California. We are a diverse community of writers and readers, activists and thinkers. Heyday promotes civic engagement and social justice, celebrates nature's beauty, supports California Indian cultural renewal, and explores the state's rich history, culture, and influence. Heyday works to realize the California dream of equity and enfranchisement.


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Johannesburg - Mining expert Peter Leon believes South Africa's mining sector could have a prosperous future ahead of it, now that the changing of the guard has taken place.
In his speech to the British Chamber of Business in South Africa last week' Leon said South Africa's new leader President Cyril Ramaphosa brought new hope to an industry that has been uncertain about its journey forward.
"The positive and decisive steps taken in the two months since Ramaphosa was elected ANC president, when contrasted with the regulatory entropy of the Zuma administration, inspire some optimism that South Africa's mining industry does indeed have a future."
He was addressing the chamber before Ramaphosa delivered his maiden State of the Nation Address on Friday evening.
Leon said Ramaphosa would hopefully once more set South Africa on a sustainable trajectory of economic growth, in which the mining sector – one of the country's oldest and largest industries – is destined to play a significant part.
Ramaphosa played a key role in the National Development Plan (NDP)' which Leon believes offers a sober assessment of the shortcomings in the South African mining industry and could recommit the country to the plan that will help build a better mining future if implemented.
Leon said that since his election in December, Ramaphosa has made a concerted effort to lure foreign investors back to South Africa. He was sworn in as SA president on Thursday, and delivered his SONA on Friday.
Welcoming investment
He said that under Ramaphosa's leadership - in contrast to its statist vision in 2012 - the ANC stated that its vision is an economy that encourages and welcomes investment, offers policy certainty and addresses barriers that inhibit growth and social inclusion.
Indeed, in contrast to its 2012 predecessor, the ANC's official policy on the mining sector is now that the ruling party should prioritise the implementation of the NDP's key proposals for minerals and metals, Leon noted.
This includes ensuring that minerals legislation provides a predictable, stable, competitive and certain regulatory environment for increased mining activity and investment, deepening linkages between mining and other sectors of the economy and undertaking research and development to find methods to lengthen mine life and use energy and water resources more efficiently.
Leon was, however, scathing about the bill to amend the Mineral and Petroleum Resources Development Act as well as the controversial Mining Charter, saying they worsened regulatory uncertainty. Ramaphosa would have to tackle both to chart a path forward.
"It is noteworthy that this statement eschews any mention of the embattled bill or charter, which the ANC had previously insisted should be 'expedited', in almost every policy statement it made on mining between 2013 and 2016," Leon said.
"From a policy perspective, this should clear the way for both the bill and the third Mining Charter to be withdrawn, and for the path of regulatory certainty to be laid."
In his address Friday, Ramaphosa said he would "intensify engagements with all stakeholders" around the controversial charter, saying that he wished to see a "genuine partnership, underscored by trust and a shared vision" between the state, labour and mining companies.
He did not, however, indicate whether he would like to see the charter scraped or amended in any way.
Break the deadlock
Leon said that even before his election, Ramaphosa remarked that South Africa must urgently break the ongoing deadlock on the regulation and transformation of the mining sector to ensure the proper use of South Africa's world class mineral resources.
"The Mining Charter is now going to be thoroughly discussed with key role players so that we find a solution to unlock our mining industry for South Africa to benefit from the boom," he said, adding that if the charter is holding the country back it should be dealt with urgently.
Additionally, Ramaphosa regards as urgent the restoration of good governance at all state departments and state-owned companies, whose networks and services he sees as crucial investment enablers; Leon called the removal of Eskom's board "encouraging".
Ramaphosa's reported refusal to offer Jacob Zuma any amnesty from prosecution in order to persuade him to hand over the keys to the Union Buildings signals an important commitment to constitutionalism and the rule of law, Leon stated.
The Chamber of Mines, meanwhile, on Saturday called Ramaphosa's maiden SONA "visionary", saying it demonstrated a "clear commitment to ethical leadership and to putting South Africa first".
'We particularly welcome the President's commitment to a new phase of engagement with stakeholders in the industry – and others – on a New Mining Charter," it said. "Ultimately a New Mining Charter must be developed and resolved through negotiation, with representation by a broad range of stakeholders – government, business, labour and communities."
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Trekking in the Forests of Yakushima
Even when our car drove up right beside them, the two monkeys sitting on the side of the road pretended to ignore us. The larger one continued to pick fleas off her smaller companion as she cast a surreptitious look our way. But on the whole the monkeys seemed untroubled by our presence. "It's a mother and child," our guide informed us. "Monkeys on the island don't bother people because we don't feed them," was his explanation for the animals'… Read more »


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I'm not even gonna say anything, but just let this sit here and marinate.
If you enjoy the content at iBankCoin, please follow us on Twitter
The warnings about potential debt hazards come as the total federal debt outstanding has surged to $22.5 trillion, or about 106% of GDP. Excluding intragovernmental obligations, debt held by the public is $16.7 trillion, or 78% of GDP.
That latter total, considered to be more relevant as an economic burden, is likely to rise to 105% by 2028, according to Congressional Budget Office projections. However, the CBO notes that the numbers are subject to revision depending on how government policies play out.
Advocates for fiscal reform argue that the debt impact has indeed reached the point where action is necessary.
"Globally, we have become over-reliant on borrowing as a solution for everything. Political excuses abound for why it doesn't matter, which just clearly isn't the case," said Maya MacGuineas, president of the Committee for a Responsible Federal Budget, a bipartisan committee of legislators, business leaders and economists that counts former Federal Reserve chairs Paul Volcker and Janet Yellen among its members.
"We are quickly approaching a situation where we have dug ourselves a debt hole which is doing to have profoundly negative effects on the economy for probably decades going forward," MacGuineas added.
In its calculations, AB Bernstein pulls in debt from a variety of sources and compares it to GDP as follows:
100% of GDP using federal, state and local government debt combined.
150% for households and firms
450% for financial debt, which carries "conceptual issues and risks," namely that debt held by financial firms often represents potential in a worst-case scenario involving various derivative instruments that can carry high notional levels that are unlikely ever to be realized.
27% in trusts for social insurance programs.
484%, which values all the promises from current social insurance programs.
633%, which tallies up an "infinite horizon" of obligations for social programs, rather than just the traditional 75 years used in computations.
Timing is everything
That total gets the debt load around the 2,000% mark, though Carlsson-Szlezak points out that different debt carries different risks.
"A default on U.S. treasury bonds would be catastrophic to the global economy – whereas changes in policy (while painful for those whose future benefits were diminished) would barely register on the economic horizon," he wrote.
Impacts on individual parts of the economy would vary.
Moody's Investors Service recently warned that an already growing number of junk-rated companies could "swell dramatically" in the next downturn, "substantially increasing default risk."
"In the next credit cycle downturn, then, the generally lower credit quality of today's speculative-grade population means that the default count could exceed the Great Recession peak of 14% of all rated issuers," Christina Padgett, a Moody's senior vice president, said in a statement.
Currently, though, credit default rates remain low as economic conditions prove favorable.
Similarly, on a macro level recession fears have proven unwarranted so far as growth continues albeit at a slower pace than in 2018. McGuineas of the CRFB said that now is the time then, for the country to start doing something about the debt situation.
"First, you start having politicians level with voters instead of promising freebies. Second, you recognize that the time to do that is when your economy is strong," she said. "When people were arguing for more borrowing they should have been doing the reverse. We're still not in recession. It's time to put in long-term strategies."


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All prices are in All prices are in ZAR
Posted by Tarryn Le Roux on 20th Sep 2016
Not just a pretty face. Hyde Guards have gone to new levels in carbon fiber protection technology. We thought we'd let you know exactly what we are hiding inside our Carbon Kevlar Infusion Guards, and why!
Most other carbon fiber guards, are made using a very simple hand laying method, with very basic carbon fiber materials. Our guards have the huge advantage of added kevlar ( the same material used to make bullet proof vests), which is infused to extract all the air from the guard.
Our Carbon Kevlar Infusion Exhaust Guard has added heat resistant silicone strips that have been specially formulated to cushion the exhaust pipe during impact, and allow air to flow between the exhaust and the guard to prevent overheating.
During our "drop test", our Carbon Kevlar Infusion Guards proved 3 to 5 times stronger weight for weight, than any of the other popular guards that we tested.
9 layers of lightweight, superior protection goes into each Carbon Kevlar Infusion Exhaust Guard to ensure optimum strength.
Take a look what's inside:
The recipe behind our guards has been developed after extensive research and intensive testing to reach a new level of carbon protection, which is why they are used by top riders worldwide.
Cody Webb Wade Young


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The Crown season 2: Will Prince Philip have an affair? Did Prince Philip cheat?
THE CROWN season 2 will be hitting Netflix today, with the show exploring the marriage troubles between Queen Elizabeth II and her husband Prince Philip this year.
Claire Foy as Queen Elizabeth II in The Crown season 2
Netflix has already released a number of trailers hinting that all is not well between the Queen (played by Claire Foy) and her husband Prince Philip (Matt Smith).
The teasers suggest that the Duke of Edinburgh could be having one affair or even a series of extra-marital dalliances.
In the most recent trailer for The Crown, Prince Philip looks very much like he is going to be playing away.
The Crown season two will also see the Queen navigating choppy waters as attitudes towards the Royal Family change.
Foy has previously teased: "No-one's prepared for what's about to happen."
While The Crown creator Peter Morgan said: "We find out things about him that I don't think many people know, but also the character of Philip is centre stage in a way that is new."
But will he have an affair in season two?
Will Prince Philip have an affair in The Crown season 2?
In season one of The Crown, Prince Philip was seen attending gentlemen's clubs regularly and was rarely at home, suggesting that he could be up to potentially scandalous things.
He paid quite a bit of attention to a waitress while out with one of his friends, indulging in raucous behaviour following his wife's ascension to the throne.
From the season two trailer, these hints have been taken a step further as it's suggested that the prince is engaging in some pretty full-blown affairs while away on duty.
At one point during the teaser he's seen looking at a woman as she dances in what appears to be an official visit.
The Queen is warned by an unseen man: "You married a wild spirit, trying to tame him is no use."
Claire Foy as Queen Elizabeth II in The Crown season 2
These ominous words are followed by a swathe of paparazzi snapping pictures, suggesting that the royal is caught up in something unsavoury.
She later tells her husband in a private moment: "This restlessness of yours has to stop. It has to be a thing of the past."
"One more scandal, one more national embarrassment and it would all be over," she adds to the Prince, who looks unimpressed at her.
The Queen seems exhausted, hinting that the couple have been rowing again and that he is frustrated and being emasculated by his wife and outranked by his son.
Photos released by Netflix earlier this also suggest at the rift between the pair growing further as they sit apart.
Claire Foy as Queen Elizabeth II and Matt Smith as Prince Philip in The Crown season 2
One more scandal, one more national embarrassment and it would all be over
Did Prince Philip cheat on the Queen in real life?
The Royal Family are deeply private, however there have been rumours of Prince Philip's infidelity, particularly in 1948 when newspapers ran a story of an alleged romance between him and actress Patricia Kirkwood.
Patricia denied the claims and the Royal Family did not issue a statement but the reports persisted through the years.
Royal biographer Sarah Bradford claimed in her 2011 book Elizabeth II: Her Life in Our Times to have spoken to women who confirmed the alleged affair.
While the Palace has never commented on the claims made in the book, other historians and authors have found no evidence to suggest Prince Philip had any affairs.
What will happen in The Crown season 2?
The action will pick up in the 1960s at a period of social change as the monarchy is struggling to modernise.
There will be political challenges as we enter the autumn of the British Empire as colonial rule is losing its influence and nations strive for their freedom.
Along with the discord between the Queen and Prince Philip, there will be potential controversy on the cards with Princess Margaret (played by Vanessa Kirby) and her new love, photographer Antony Armstrong-Jones (Matthew Goode).
Season two will see President John F. Kennedy (Michael C. Hall) paying a visit to London with his wife Jackie (Jodi Balfour).
When is The Crown season 2 released?
Netflix has announced that The Crown season two will be released in its entirety on Friday, December 8.
The Crown season 2 will be available on Netflix on December 8.