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Back to Archived Journals » Gastrointestinal Cancer: Targets and Therapy » Volume 5
Prospective prediction of resistance to neoadjuvant therapy in patients with locoregional esophageal adenocarcinoma
Authors Rosen D, Shan W, Lassen N, Johnson C, Oelschlager K, Bierman-Harrar Y, Kesler K, Maetzold D, Badve S, Cook R, Saxena R
Received 16 October 2014
Accepted for publication 12 December 2014
Published 19 February 2015 Volume 2015:5 Pages 53—59
DOI https://doi.org/10.2147/GICTT.S75904
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Eileen O'Reilly
Daniel G Rosen,1 Weiwei Shan,2 Natalie Lassen,2 Clare Johnson,2 Kristen Oelschlager,2 Yaeli Bierman-Harrar,1 Kenneth A Kesler,3 Derek Maetzold,2 Sunil Badve,3 Robert W Cook,2 Romil Saxena3
1Baylor College of Medicine, Houston TX, USA; 2Castle Biosciences, Incorporated, Friendswood, TX, USA; 3Indiana University, Indianapolis, IN, USA
Background: To clinically validate a multianalyte algorithmic immunohistochemistry (IHC) assay that has been previously shown to accurately identify patients with locoregional esophageal adenocarcinoma (EC) who will exhibit extreme resistance to neoadjuvant chemoradiotherapy.
Methods: Archived biopsy specimens of EC were subject to IHC examination of compartmentalized immunoreactivity of nuclear factor kappa B (NF-κB), Sonic Hedgehog (SHH), and GLI family zinc finger 1 (Gli-1), and a labeling index score was assigned to each biomarker. Test prediction was generated by logistic regression predictive modeling, using the labeling index scores for all three analytes from each sample, referring to a validated training set of 167 EC patients. Accuracy of the test was determined by comparing the predicted outcomes with pathologically determined College of American Pathologists tumor response grade. Analytical validity of the test was measured by comparing validation set prediction results obtained in two independent Clinical Laboratory Improvement Amendment-certified laboratories, and by measuring concordance between two trained labeling index readers.
Results: Specimens from 64 patients that met specific criteria were collected. No technical failure was encountered during the IHC labeling procedures. The logistic regression algorithm generated an area under the curve of 0.96 and 0.85 for the 64 sample cohort in two independent clinical laboratories, respectively, comparing predictive results with the established training set. Positive predictive values of 88% and 82% were also achieved in each laboratory, respectively. A negative predictive value of 83% was reported by both laboratories. Interobserver concordance was 97%.
Discussion: We report the second validation of a multianalyte algorithmic IHC-based predictive test that accurately identifies EC patient response to fluorouracil-based neoadjuvant chemoradiotherapy regimens under College of American Pathologists-accredited Clinical Laboratory Improvement Amendment-certified laboratory protocols. The validated assay provides the opportunity to identify patients with EC who have extreme resistance to neoadjuvant chemoradiotherapy who are resistant to fluorouracil-based neoadjuvant chemoradiotherapy, allowing for more effective treatment planning by clinicians and less toxicity for patients.
Keywords: neoadjuvant chemoradiation, immunohistochemistry, predictive test, validation
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]


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While most of the autographs in our inventory are obtained in New York City, GMAA also travels to select film festivals and conventions from time to time. While only some of our items come with proof pictures (that is, a photo of the person signing the item), we offer a. One of our items is. It is therefore extremely likely that if you are interested in an item that you do not see here, we still may have it in stock or could obtain it in the near future. To browse our other items.
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WATCH: Hong Kong student refused diploma after opening yellow umbrella at graduation ceremony
A Hong Kong student was refused his diploma for opening a yellow umbrella on stage at a graduation ceremony on Saturday (Nov 15).
The yellow umbrella became a symbol of pro-democracy protests, led by students, which began on Sept 28.
In the clip, Hong Kong Baptist University's vice-chancellor is seen reprimanding the student before asking him to walk off stage.
The student obliged by leaving the stage while holding up the opened umbrella.
Students among the audience can be heard voicing their disapproval over the diploma snub.
According to Shanghaiist, students in the audience began opening up yellow umbrellas of their own, enraging the vice-chancellor who postponed the ceremony to the next morning.
Reports said that the next day's graduation ceremony turned out the same way as the vice-chancellor refused to hand over the diplomas again.
Meanwhile, authorities on Tuesday (Nov 18) cleared part of Hong Kong's main pro-democracy protest camp.
They faced no resistance as they launched the first of several planned evictions to reopen roads blocked for nearly two months.
Dozens of police and bailiffs stood guard on Tuesday as workers dismantled metal barricades blocking access to a skyscraper opposite government headquarters, on the edge of the sprawling main camp in the central Admiralty district.
Source: Shanghaiist, Apple Daily, AFP
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MainView Console Management NEW 1 step rule generation wizard writing a rule to escalate important messages and automating the shutdown/IPL process is simple. As you know automating the IPL process is one of the more difficult and most important tasks because of the manual intervention required to perform an IPL process.
With the 3.3 release of MainView Console Management, writing an IPL rule is dramatically easier. Instead of creating a rule from scratch using IBM's proprietary language and typing in key elements (which consume time and are prone to error), the rule writer will simply launch a form and copy/past elements of a message into the form. Just fill in the blanks by, for example, defining the trigger (a specific job ID), choosing an action (send an email) and appropriate details (email address), and – voila! - You're off and running. The form has created the bulk of the rule. Save, compile, and apply. Done.
As you can see creating a rule has never been easier. It's just like checking your favorite team scores. You open a browser, enter your teams name or title what you're naming your rule followed by some quick and easy mouse clicks, and voila! – You have your teams' scores or in our situation you just generated an automation rule.
To see rules generation wizard in action watch our video.


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My granddaughter, Lacey, loves wolves and she wished to brighten her bedroom in a wolf theme. Perhaps your lavatory is just too big and you think a few of that space could possibly be dedicated to a different area of your property (resembling a stroll-in closet). A floating vanity not only looks fashionable and sophisticated, it saves treasured flooring house as properly. I really loved this lens, even if I don't intend on redecorating the bathroom in the mean time.
Enamel-on-metal sinks have been especially sturdy and stain-resistant, as have been chrome steel sinks, which are becoming more popular for use in loos. For example, you can refinish cupboards to make them look brand new and flow with the brand new rest room for much less cash. Depending on the amount of space you've gotten in your toilet, these over-sized single vanities can add a stylish accent to a remodeled bathroom. Remodeling Magazine cited $15,782 because the nationwide common for bathroom remodels.
Before we acquired began one of many bathroom cupboard doors fell off the hinge; we noticed the sunshine fixture was rusting from shower steam. There are many ways to increase the area or even look of house in your small lavatory with some easy renovations. If you want to give your Zen toilet a contemporary and splendid contact, think about glass or mosaic tiles. We preferred the parquet wood flooring all through the kitchen and dining area, the livingroom, hallway and master tub. If you may have an enormous collection of towels however not sufficient cabinet house, you would possibly need to hold some of them outside of the lavatory.
However, it is easy to lose sight of this requirement when trying to handle the price of a full toilet renovation. When you need to minimize a tile, to accommodate lavatory fixtures, just be sure you first measure at what distance it's a must to cut the tiles. Oh my gosh…I may transfer proper in to that Zen lavatory with the palm tree and enormous shaded window.
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We provide clinical and medical waste units with safe and secure storage. Clinical and medical waste can be used for everything from general waste to clinical, cytotoxic waste and pharmaceutical waste. All such waste results from dental, medical and other potentially hazardous waste.


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Following years of struggle, Ramona Soto concentrates solely on her career as manager in the legal department of a major Denver firm. After slogging through low-paying, dead-end jobs while putting herself through college, she's found success at Pursuit Telecom Ltd. She makes decent money for herself and her teenage son, but not nearly enough to send him to college. Enter Desmond (Des) Emmett. Hired to handle the security department, the ex-serviceman fills every condition on Raye's mental list … [Read more...] about Never Retreat by Bonnie McCune
The Milkman: Book I by Greg Buck
The Milkman: Book I by Greg Buck If you were offered $10,000 dollars to make someone 'disappear', what would you do? Jesse Hardner is nineteen years old and working as a milk man to support himself through college. Since an accident which killed his father and injured his mother, Jesse has also taken on the role of carer. He has far less time than he'd like to shoot hoops with his friends, develop his relationship with the girl he's fallen for, and get his old Firebird back on the road. As … [Read more...] about The Milkman: Book I by Greg Buck
Interview with Author – Greg Buck
About Greg Buck: I was born in Denver, Colorado and have always called Colorado home. I graduated from Metropolitan State University in Denver and have been a software engineer for over 27 years. Currently living in Westminster, Colorado with my wife and 3 dogs. I am an avid fly fisherman, fly tier and archer. What inspires you to write? I never even thought about writing a book until one morning while walking to the bus stop for my commute to work, I witnessed a milk man screeching to a … [Read more...] about Interview with Author – Greg Buck
Blinded by Lyz Kelley
Blinded by Lyz Kelley Murder, Romance, Mayhem, Oh, my! Immerse yourself into Elkridge as each couple learns to conquer their fears while fighting for love. Plus, discover clues left to answer the question: Who murdered Sheriff Sam? If you like a sensual romance, intense, emotional topics, a thread of mystery, and a cozy happy ending, then the Elkridge Series is for you. Let's have some fun, shall we? Purchase your copy of BLINDED to start solving the mystery … [Read more...] about Blinded by Lyz Kelley
Bargain Book: Duplicity by Diane Winger
This book is bargain priced from 06/27/2014 until 07/01/2014 All Curt wants is a simple, quiet life, and he relishes the solitude of his job as caretaker of a backcountry ski hut. His peaceful world is shattered by the reappearance of his identical twin brother, fresh out of prison, desperate and more dangerous than ever. Conrad has a plan and that plan may destroy Curt's future. Not only is Curt's life at stake, but also the lives of a group of women enjoying a skiing getaway. Jessie and … [Read more...] about Bargain Book: Duplicity by Diane Winger
The Taste of Metal by Joe Hnida @JoeHnida
"It's like I've got a shotgun in my mouth, with my finger on the trigger, and I like the taste of the gun metal..." - Robert Downey Jr. The drugs just sort of happened. It's not like I'd traveled to Denver, Colorado to become immersed in the burgeoning marijuana scene, although it was hard to avoid. When I showed up, the pot industry in the Rocky Mountains was booming and with the recent passing of Amendment 64, was on the tipping point of becoming revolutionary. Still, legal weed was the … [Read more...] about The Taste of Metal by Joe Hnida @JoeHnida
A Book to Die For by Richard Houston
This book is bargain priced from 05/03/2014 until 05/08/2014 It took hours for him to die; time enough to wish he had never read the book. His death should have been quick and merciful. Unfortunately, few murders go according to plan. A Book to Die For features Jake Martin and his golden retriever, Fred, from Houston's best seller, A View to Die For. Jake is not your ordinary sleuth. He's an ordinary guy with an extraordinary dog. This time the story takes place in the foothills of Denver. … [Read more...] about A Book to Die For by Richard Houston
Rockfall by Diane Winger @WingerBooks
This book is bargain priced from 04/14/2014 until 04/16/2014 Two horrified witnesses watch as a mountainside crumbles, crashing down on a party of hikers. Searchers find no signs of life. Three missing, all presumed dead. Three families begin the difficult process of grieving. But one of the missing is alive. Alone, injured, and terrified, she struggles to survive, hoping against all odds that someone will find her…before time runs out. Emotionally charged and engrossing, Rockfall is a … [Read more...] about Rockfall by Diane Winger @WingerBooks
The Parting Glass: A Mrs. Meade Mystery by Elisabeth Grace Foley @elisabethgfoley
Mrs. Meade is not the only one in Sour Springs who is shocked at the news when Clyde Renfrew is accused of a drunken assault on a woman. Clyde, a sober, steady young rancher, seemed the last person likely to do such a thing. Between an emphatic witness and Clyde's own apparent reluctance to defend himself, the case seems open and shut. But Mrs. Meade—who seems to have a knack for being just across the hall when things happen—has a few ideas of her own… The Parting Glass is a novelette, … [Read more...] about The Parting Glass: A Mrs. Meade Mystery by Elisabeth Grace Foley @elisabethgfoley


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A UK staple, Cheese is one of the most commonly seen strains in the UK today. The Original clone only UK strain exodus Cheese is said to be a rare Skunk #1 phenotype. Standing out due to her very distinguished sour dairy aroma.
Our Cheese comes from a long worked Cheese line selected for uniform, high yielding and heavy resin production. The strain has added Afghani genes bred in back crossed and then the line worked selecting plants that retained all the classic "Cheese" characteristics.
Our version yields above average and will usually take between 7 -9 weeks depending on personal preferences. This girl has true Exodus Cheese genetics and has been selectively bred For that classic sour, cheesy aroma. She does well both outdoor and indoor, inside you are going to want good filtration to combat late flower smells. Suitable for scrog and other low stress techniques.
We did several Cheese auto trials in 2018 to select the best automatic variety based on performance, yield and overall effects. We would like to thank Hemel Hempstead , Milton Keynes, Durham and Swansea Cannabis Clubs and also to Ismoke magazine for helping in our selections and also to all the growers who took part in this project.
All our seed packs contain premium quality feminised seeds.
At Aztech Smoke shop all orders come with free seeds included. All orders will receive 2 regular seeds and orders over £10.00 will also include one free feminised seed too. For details of our current free strains please check here. You can also sign up to our monthly email too to keep up to date with new product and strain information.


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How many games ask you to control two characters at once - with only one controller?
Twisted Pixel's XBLA puzzle platformer 'Splosion Man was an unexpected success in 2009. While the indie developer is working on Kinect shooter The Gunstringer, it's also working on a 'Splosion Man follow-up - called Ms. 'Splosion Man, in the vein of Namco's omnivorous yellow puck.
Presumably Ms. 'Splosion Man has a normal mode like the original, but it also has an additional type of gameplay called "2 Girls 1 Controller," and if you don't get the reference then I'm certainly not about to explain it here.
The mode is exactly what it sounds like: One player must control two Ms. 'Splosion Mans ('Splosion Men?) on one controller. The left thumbstick and left shoulder bumper control the movement and 'sploding of one; the right thumbstick and right shoulder bumper control the movement and 'sploding of the other. Presumably, if either one dies it's back to the checkpoint.
Frankly speaking, this looks positively brutal. I could barely control one 'Splosion Man in the original - I don't think I could ever handle controlling two at once.
There will be more information on the game in the June issue of Game Informer.
(Via Joystiq)


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Telford residents have been getting in shape with the help of staff from a local retirement living scheme and their annual Healthy, Happy Week.
Sanctuary Housing's Hartshorne Court, on Burton Street, opened its doors from Monday 7 to Friday 11 November for dozens of people to attend a series of free events aimed at boosting their physical and mental wellbeing.
The week's activities, which were funded by Great Dawley Town Council, saw visitors receive health checks from Telford and Wrekin Council's Healthy Lifestyle Hub, take part in workouts at Dawley Park's outdoor gym, enjoy healthy meals, try some adult colouring and attend a falls prevention class.
Scheme manager Vivienne Chalmers said: "Healthy, Happy Week has been a fantastic success and we were delighted to have seen so many people join us and take part in our wide range of activities.
"The week was a great way for lots of people to find new ways to improve their physical and mental health and meet new people in the process."


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MasterCard Must Stop Hurting EU Merchants
(CN) – The EU General Court has slammed MasterCard for charging merchants to process credit card transactions.
Under the MasterCard system, a card-issuing bank retains part of all charges that a consumer applies to his payment cards. Since the merchant must swallow that loss, known as multilateral interchange fees (MIFs), the European Commission found that it constituted a price-competition restriction.
In 2007, the agency ordered MasterCard to repeal the MIFs within six months or face fines of 3.5 percent of its daily consolidated global turnover.
MasterCard and two subsidiaries appealed the commission's decision to the EU General Court, claiming that banks would have to offer competing payment cards or reduce cardholder benefits if they lost the MIFs.
Though MasterCard said both options would affect its viability, the Luxembourg court found that MasterCard has plenty of other sources of revenue aside from MIFs.
The court pointed to several banks that do not charge MIFs and noted that banks in the U.K. make 90 percent of their income from credit card interest, and only 10 percent from interchange fees.
"It must be observed that the existence of such revenues and benefits makes it unlikely that, without a MIF, an appreciable proportion of banks would cease or significantly reduce their MasterCard card issuing business or would change the terms of issue to such an extent as to be likely to result in holders of those cards favoring other forms of payment or turning to cards issued under three-party schemes, which might affect the viability of the MasterCard system," according to the ruling.
"In other words, while a reduction in the benefits conferred on cardholders or the profitability of the card issuing business might be expected in a system operating without a MIF, it is reasonable to conclude that such a reduction would not be sufficient to affect the viability of the MasterCard system."
Since the fees are not objectively necessary to MasterCard's economic viability, the commission correctly considered how MIFs affect competition, the court ruled.
The commission found that, without the MIF, merchants could exert greater competitive pressure on costs they incur for accepting credit cards.
MasterCard also failed to shuck the bank label that the commission applied, though its 2006 Initial Public Offering forced financial institutions to give up control of the company.
"It is nevertheless apparent from the matters of fact and of law … that the banks continued, collectively, to exercise decision-making powers in respect of the essential aspects of the operation of the MasterCard payment organization after the IPO, both at a national and at a European level," the court found.
"Those banks, as the commission rightly pointed out … benefit, by virtue of the MIF, from a minimum price floor which readily enables them to pass on the MIF to merchants," according to the court.
"Thus, in the context of the banks' acquiring business, the MIF represents a cost for the banks only if they decide to absorb it themselves," it added. "However, it is apparent … that that is the exception rather than the rule."
The judges also upheld the commission's threat of fines to force compliance as neither excessive nor disproportionate.
"The obligation formally to repeal the MIFs, to modify the association's network rules and to repeal all decisions on MIFs … is a direct consequence of the finding that those MIFs are unlawful," the court concluded. "It is not disproportionate therefore, as it is confined to bringing the infringement at issue to an end."
MasterCard has 60 days to appeal the court's decision to the Court of Justice, on points of law only.


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IBPS Recruitment 2018: Institute of Banking Personnel Selection (IBPS) has released the official notification for Various Store Keeper, Driver Posts. The selection of candidates will be done through the followed on Preliminary Examination, Main Examination, Interview. So, candidates who aspire to apply can now apply for a job through the official link given below.
Education qualification to apply for this job is Minimum Graduation Pass. After getting selected candidates can get payments as per Rules. Institute of Banking Personnel Selection (IBPS) has started accepting an application form 14th August 2018 till 04th September 2018. So, candidates who need to apply for this jobs kindly apply as soon as possible.
Eligibility Criteria for IBPS Recruitment 2018
The Eligibility criteria for Education Qualification, Age Limit, Salary, Grade pay is as follows:
Education qualification:
Various Store Keeper, Driver Posts: In order to apply for this post candidates should have completed Degree (Graduation) Pass recognized University/Institute.
1. Probationary Officer
2. Management Trainee
Total Number of Vacancies: 4102 Vacancies.
Job Location: After Selection Candidates will be posted in All Over India.
Selection Process: Selection of the candidates will be totally based on Preliminary Examination, Main Examination, Interview.
After getting Selected candidates can get huge salary packages as follows:
|Various Store Keeper, Driver
|As per rules
Age Limit:
Age Limit for the post of Various Store Keeper, Driver Posts Vacancies.
Various Store Keeper, Driver Posts – The Candidates Age Limit is Minimum Age 20 Years Maximum Age 30 Years.
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Various Store Keeper, Driver Posts, Candidates have to pay an application fee. The PWD (Persons with Disabilities) candidates are exempted from paying any application fees.
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Official Notification: Click Here to Download
Online Application: Click Here to Apply
For more Govt Jobs: Click Here


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Well, that's a big relief.
At times during the past week, I've found myself doubting the judicial system -- but the Bell verdict has restored a lot of people's faith. What nobody seems to be wondering is: What will happen to those poor kids? ---
It seems unlikely that there will be any apologies forthcoming from Lulu Latu and her friends for putting Bell through all this. When prosecutors failed to lock Bell up for 30 years, Lulu's response was to run down the hallway in hysterics (seen in this Fox 13 video at about 2:15):
Indeed, it seems jurors were not amused that the case was brought to trial at all, going so far as to speculate how much the proceedings must have cost the taxpayers.
I'm concerned at how much the whole business has cost poor Bell. I'm sure with the support of family and friends, he'll now be able to pick up the pieces of his shattered life -- but how can Lulu Latu and all the others possibly repay the 14 months of hell he has undergone? What about the damage to his public reputation? And what about the lasting injuries -- including rumored possible brain damage -- Bell sustained from the senseless beating?
And there's one more question that has been absent from these proceedings: namely, what about the children? Now that it has been ascertained that there was no kidnapping, how could these small children have been allowed to wander away from the fold during an all-night party and find themselves in a neighboring house?
It's lucky that the kids wandered over to the house of nice people like Bell and Dan Fair -- but what if, instead, they had wandered into a crack-den, or worse? I only hope for the kids' sake that their parents can be trusted to stop this behavior of hanging out with fag-bashers and allowing their children to venture out God-knows-where at all hours of the night.


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Perth jockey Lucy Warwick expects to be racking up the frequent flyer points in coming weeks as she jets across the country to ride Material Man.
Trained in Western Australia by her father Justin, Material Man runs in Saturday's Group One Futurity Stakes at Caulfield, the start of a possible four races in as many weeks leading to the All-Star Mile at Flemington on March 16.
Material Man was one of the top 10 vote getters announced for the All-Star Mile on Thursday.
Following Saturday's run, Material Man may run at Flemington on three consecutive Saturdays, starting with the Blamey Stakes, leading into the Australian Cup and then the All-Star Mile.
"He's nominated for the four Saturdays in a row so I'll be racking up the frequent flyer points if that happens," Warwick said.
"But I'll leave that up to Dad."
Warwick said she would not be overawed partnering Material Man in the $5 million All-Star Mile.
She said the experience of riding in three Group One races in Melbourne leading up to that race would hold her in good stead.
Material Man made his eastern states debut, finishing sixth behind Manuel in the C F Orr Stakes at Caulfield last Saturday week, a run Warwick said was a confidence booster.
"From day dot, this is what I've wanted to do, especially for Dad who has helped shape my career," Warwick said.
"To be here on his horse, is a dream come true.
"As Dad says, he's a very easy horse to train. He loves his job, he loves his racing and the main thing is to stop him from working too hard.
"He's fit, he's drawn barrier four and hopefully we get a good run and I can't see why he won't run a good race."
Warwick has won the 2018 Group Two Perth Cup on Material Man and said a Group One win on the gelding would be a dream come true after guiding him to placings at the highest level in Perth.
"He's a favourite and I've missed out on a few wins because of falls," Warwick said.
"I missed a Bunbury Cup and an AHA Cup which I was devastated about at the time, but I'm now here in Melbourne and that's water under the bridge."


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Senior Quality Assurance Engineer
Are you able to support product development teams as a professional Senior Quality..
Ambu A/S
Are you able to support product development teams as a professional Senior Quality Assurance Engineer? Do you have experience in risk management and design control? Do you want to be part of a truly global organisation with high professional standards, that value to quality in products and processes, and do you want to make your daily efforts matter?
Then we have an exciting job opportunity that may be your next career move.
As part of the Corporate Quality Assurance Engineering team, you will support product development teams in developing and introducing medical devices within our product range.
Working from our Headquarters in Ballerup, you will join a team with colleagues in Denmark, USA and Asia, and you will refer to the Director of Corporate Quality Assurance Engineering.
A global job with an impact
In the job as Senior Quality Assurance Engineer, you will have the chance to impact product development and your own daily tasks and responsibilities. You will experience a very varied working day in a dynamic organisation. You will work closely with your colleagues, particularly colleagues in Denmark and Asia, but also in the US.
Your main responsibilities will be to:
- Ensure professional and proactive QA Engineering support to the development projects
- Responsible for risk management as part of support to innovation projects
- Perform supplier audit as part of selection new suppliers to innovation projects and continuous monitoring of strategic suppliers
- Continuous development of products through quality tools as Corrective and Preventive Actions
You can expect some travel activity (10-20 days per year) in connection with development projects, supplier audits, conferences, etc.
Experience with Medical Device and teamwork
To succeed in the job, you need to have a background as engineer with more years of experience within design control of medical devices in a QA department and you have experience with performing risk management for Medical Devices. Additionally, you need to have experience with Supplier Audits and preferable a trained lead auditor. Your professional background is biomedical, mechanical, electrical or software engineer.
It is important that you have a structured approach to your work, but at the same time, you are open-minded and see possibilities. You have a clear ability to maintain overview in a at times hectic environment and you are a team player with the ability to work independently.
It is natural for you to take charge and you are proactive, good at prioritising, planning and finalising your tasks.
Ambu is a global company and English is our corporate language, which requires that you speak and write English at a relatively high level.You will use English every day in your job.
Ambu - a visionary and international workplace where your efforts matter
Ambu is a company with ambitious growth targets. We meet these targets through interdisciplinary teamwork between motivated and competent employees in an informal working environment. Your contributions and efforts are crucial to our success. At Ambu, you can make a difference. Ambu is a company in rapid growth and development, which calls for a natural focus on the on-going development of your professional and personal competences contributing to Ambu's continued success.
We offer a wide range of professional, social and financial employee benefits, which, in addition to the exciting job challenges, contribute to your job satisfaction.
Information and deadline
If you are interested in the position, then please apply as soon as possible and no later than 19 January 2020.
Your application will, of course, be treated confidentially.
If you have any questions about the position, you can contact Director, Corporate Quality Engineering Karsten Randrup Kragh on +45 7225 2000
Please write in your application that you've seen the job at Jobfinder.


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http://www.cjscareers.com, www.careerinyoursuitcase.com
Schuttersveld 27
I believe that the skills to navigate career transitions are life skills for today's world. That's why I teach people the career development skills needed to navigate their careers across occupational boundaries, international borders and economic shifts, and create a personally meaningful career in today's labour market.
I am a trained self employed career consultant. In 1998 I started CJS Career Consulting in Canada and since 2006 I have been based in the Netherlands. I am certified as a Global Career Development Facilitator (GCDF), am qualified to deliver Personality Dimensions training and am an NLP Practitioner.
Terwijl ik vooral in het Engels werkzaam ben, spreek ik ook vloeiend Nederlands.


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- 【Fast delivery】: Ship from the United States, the delivery time is about 7-12 days. Our products are zero profit and we want to protect children
- 【Material】Made of environmental friendly material,breathable,soft to the touch, durable, no damage to the skin, and can protec𝓽 the face well.
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Be appropriate, don't appropriate this Halloween
By Quintez Brown —
Another year of thrills and chills calls for another reminder that CULTURES ARE NOT COSTUMES.
It's not a hard concept to grasp. You would think people would learn by now to not be so insensitive with their costumes. It's not difficult to see how blackface, headdresses, sombreros, etc are derogatory and offensive, even if unintentional.
James Ramsey, president Neeli Bendapudi's predecessor, learned his lesson after his disastrous sombrero picture a couple years ago.
Thankfully our new, amazing president would never pull such an insensitive, racist stunt.
In an email sent to all students, respect and cultural competency were stressed and emphasized by dean of students Michael Mardis and vice provost for diversity and international affairs Mordean Taylor-Archer.
"As we approach Halloween and the many activities related to it, please take time to consider your fellow Cardinals when choosing costumes and themes," the email said.
The email also recognized Bendapudi's efforts to make diversity a priority on campus.
"As President Bendapudi has stressed, we are working to make the University of Louisville a great place to learn, to work and to invest. She adds that we will do so by developing a culture that celebrates diversity, fosters equity and seeks to achieve inclusion."
Her commitment is reflected in the C.A.R.D.I.N.A.L. values she described at her inauguration, where the D stands for Diversity. Hopefully, our campus community will understand the importance of this commitment.
Halloween is a fun, silly holiday where you're supposed to be creative and let your imagination run wild. There are a million costumes to choose from. You can be basic and be a ghost. Or you can think outside the box and be a pair of Gucci slides.
Just don't be a "sexy Native-American" or a "drunk Mexican" or wear something like a hijab or kippah that's actually part of someone's religion or culture.
Also, try not to color your face with dark face paint. Blackface has a long history in America of being used as a racist stereotype. Unfortunately, every year around this time we continue to see the same behavior, espicially at college parties. Some argue that people are too sensitive and Halloween is not the time to be "politically correct".
Blackface goes beyond politics. By painting your face black and turning someone's identity into a caricature, you are contributing to a centuries-long history of systemic racism and implicit bias that has vilified, dehumanzied, and marginalized African Americans.
Saying you're not racist or saying that you have black friends doesn't change how your costume can affect and harm the people that you're mimicking. Not just the people that see your costume, but a whole race of human beings that you just stereotyped and mocked.
"It is important to remember that blackface and other forms of cultural appropriation are culturally insensitive and may be offensive to others. This is particularly true of costumes that depict other races, cultures and/or identities," the email said.
Your privilege may not allow you to see how your costume is offensive to your neighbors, but when you mock someone's identity right in front of their face, you're telling them their language, dress and customs aren't worthy of respect.
We don't want to hinder your freedom of expression or choice for costume. We all want to enjoy the holiday. It's not people trying to create a problem out of anything, it's simply asking for respect and consideration.
"Thoughtful consideration of how our dress and actions can have a negative impact on others will help allow all of us to have the opportunity to enjoy the holidays and other events without controversy," the email said.
You can appreciate others' cultures and celebrate them, but Halloween is not the appropriate time for this. And it's never an appropriate time to mock or appropriate our neighbors' cultures.
Let's think, stay safe and have fun during this spooky season.
Pictured: Former president James Ramsey (far right) and staff pose for a photo in racially insensitive costumes.
Photo Courtesy / The Courier Journal


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No: 306, 22 October 2019, Press Release Regarding The Decision To Recommend Ambassador Ahmet Altay Cengizer's Designation As President Of The 40th General Conference Of The United Nations Educational, Scientific And Cultural Organization (unesco)
During the voting held on 22 October 2019 at the Executive Board of the United Nations Educational, Scientific and Cultural Organization (UNESCO) for the Presidency of the 40th Session of the UNESCO General Conference, to be held in Paris on 12-27 November 2019, Ambassador Altay Cengizer has been selected against his Spanish competitor.
The result of the voting in the Executive Board is a recommendation and the General Conference, which will initiate its proceedings on 12 November 2019, shall approve this decision.
The UNESCO General Conference held biennially is the organisation's highest decision-making body. The President of the General Conference, together with the post of Director-General and Chairmanship of the Executive Board, is one of the top three UNESCO assignments and ranks at the top of the protocol.
The objective criteria based on the personal knowledge, qualifications and experience of the candidates are effective for the election of the President of the General Conference. The result of the election is a reflection of the activities and fair attitude of Ambassador Cengizer, who represents our country in the Executive Board that has been elected for the 2017-2021 period, as well as his personal qualities that are well appreciated in UNESCO circles.
We believe that Ambassador Cengizer, who will serve for the period of 2019-2021, will make valuable contributions to UNESCO and we wish him every success.
Monday - Friday
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1-888-566-76-56 veya +90 312 292 29 29


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– Voted one of the Top 100 Golf Ranges in the USA –
The Western Mass Family Golf Center is the area's favorite golf practice facility and learning center. It offers a 50 station natural grass tee and artificial mat range, practice sand bunker, short chipping area, and a putting green. People of all ages and abilities enjoy practicing and sharpening their skills at the WMFGC.
Covered mat tees provide protection from inclement weather and the range is lighted for night practice. Range clubs are available to use at no extra cost.
The Family Golf Center is now powered by TopTracer Range. Eight of our covered bays are equipped with this game changing system that offers you stats on each shot and games to challenge yourself and friends.
Range Bucket Prices
Summer Pricing:
Small (30 balls) – $6.00
Medium (60 balls) – $10.00
Large (105 balls) – $15.00
Grass Tee Fee – $1.00
We have range clubs available at no extra cost
Winter Pricing:
Medium: $10.00 (60 balls)
We have 4 heated stalls available during the winter months. Medium buckets available via token machine. – Cash only – Grass tees are closed for the winter season.


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Senior Front-end Developer
As part of Lightspeed's Golf product group, you will contribute to initiatives that will expand our reach within the golf market while enhancing our cloud based management software. We're looking for a senior front-end developer to drive our transition toward Lightspeed Design system and technical stack. At Lightspeed, we are dedicated to bringing cities and communities to life by powering SMBs. Come and help us build our communities!
What you'll be responsible for
- Help define a critical strategy to onboard new and old applications on Lightspeed design Systems.
- You will be responsible for designing and implementing new features on our back office and marketplace applications.
- Report to the Development Manager and have frequent interactions with Product Managers, Product Designers, Customer Service as well as Platform Teams.
- Take part in daily agile ceremonies and share new ideas based on your knowledge and experience.
- Raise the bar and elevate your team by sharing knowledge and best practices, while always seeking improvement and progress.
What you'll be bringing to the team
- 5+ years of professional experience, though it's more important what you know and what you can do.
- Senior experience with Angular & Typescript
- A good understanding of Javascript in general
- Critical thinking regarding UI and UX
- Experience delivering product features
- Experience mentoring or coaching team members
- Excellent communication skills
Even better, but not necessary
- Experience with React
- Experience with Design Systems
- Skills in UI building (HTML, CSS)
*Not sure if you meet 100% of our qualifications? Please apply anyway!
What's in it for you
- Lots of autonomy, flexible work culture and possibility of remote work
- Exposure to modern and proven technology
- Innovation time to explore and learn at work
- Shaping the company by joining cultural & technical committees
- Tons of growth opportunities into technical or people management roles
- Amazing benefits & perks, including equity for all Lightspeeders
- Opportunity to join a fast-paced, high-growth company
- Opportunity to learn, expand your skill set, forge wonderful relationships and make your mark within the diverse and inclusive Lightspeed family, a true Canadian tech success story.
Our Golf software offers a competitive advantage in an industry where pen and paper is still a thing. A strong integration with our POS and Restaurant systems make it a de-facto choice for golf clubs who want a cloud-based centralized management software for their facility. A strong and growing team of 60 people, you will feel the drive of our go to market team, the serenity of our customer success team, and the meticulous attention of our product team!


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An 11-year-old Allen boy who was paralyzed after suffering from a suspected case of enterovirus 68 is showing signs of improvement at Our Children's House at Baylor.
WFAA-TV's (Channel 8) Janet St. James reports that Bryan Sotelo had lost sensation in his limbs and couldn't even speak when he arrived at OCH last month.
Now, Bryan is using his legs and reaching and grasping for things. Occupational therapy is helping him progress and he is expected to be released early next week, according to the report.
[Watch the full WFAA-TV report for more on Bryan's recovery.]
More than 1,000 cases of enterovirus 68 across the country in recent months have caused great fear. It is associated with severe respiratory illness and can include symptoms ranging from runny nose, fever, sneezing and cough to wheezing and difficulty breathing, according to the Centers for Disease Control and Prevention.
Infants, children and teenagers are most at risk, according to the CDC, and children with asthma are thought to be at higher risk for severe respiratory illness caused by the infection.


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If you are also the one among all the women who is facing complicated problems dye to black color, then you are at the right place. Here you are going to know about many courses that help the black women in improving their self confidence. Among all the courses present out there the best and most helpful related to the same aspect is Pink Pill. One should take participate in the same course and then attend classes to improve their confidence or also by doing so their standard and personality improves.
How to know about pink pill course?
Everyone should know that there are lots of classic courses present among which the best one is pink pill. Now to gather more information about pink pill one should make use of the reviews or directly visit https://twitter.com/christelyn. It is the only way by which you simply become able to know everything about pink pill and also you can easily know how to use the particular course to get positive results and get rid of the problem of black color.
Top 2 benefits
Here are mentioned two main benefits which the black women get when they make use of pink pill course. By knowing them one should know the importance of the same course in the field of black women.
- Improve personality and standard – every black woman should know that by taking part into pink pill course the personality and standard of a person. It is the best way to get success in your life easily and get rid of the problem of black color.
- Enhance self confidence – black women should know that the best benefit of taking part into pink pill course is that your self confidence increases a lot.
These are the best 2 benefits which the black women should know and then make its appropriate manner. Now only is this, there are lots of courses present but the black women need to choose and then get appropriate services. It is the best way to improve your confidence, personality and standard.


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Flight Booking
Hot Deals
Lonelyindia is a travel and package management company that specializes in green tourism. Our tours are designed to take the customer into the lap of nature without the endangering the delicate ecology system or harming local communities.
Rafting Camping
Himachal Pradesh and Uttrakhand has a cultured and colourful society. When it comes to tourism, Himachal Pradesh and Uttrakhand has something for everyone. It is simply a paradise for the adventure sports lovers..
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The goal of meditation is to give you more way to concentrate on your life.Its stop letting them control you.Meditation and Yoga gives you reason to smile and its the great moment to get positive vibes with your own priorities..
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Its all necessary to have a good environment with a good room which
we give you.We provide the best luxury
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Eg:- Parking,Garden,Swimming Pool,The Best Services, etc..
Useful Links
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Jurgen Klopp has, quite naturally, stated that he'll only be happy with his team's work this season if we finish in the top four and enter the Champions League for next term.
We're currently in third spot, but Manchester City will climb above us if they win their game in hand and United will go level if they win both of theirs – so it's going to be mighty tight with six weeks remaining.
"I will only be satisfied if we reach the Champions League," the Liverpool boss told Sky in Germany.
"You are always under pressure," Klopp said. "In every game there is pressure.
"You need to win all the time. I'm only satisfied when the team wins."
Our run-in, is on paper, easy, but this term we've made a mockery of that by beating our rivals consistently and dropping points against sides in the bottom-half.
In fact, we've won more points against teams in the top half than bottom, which has never before happened in a Premier League campaign.
It's West Brom at the weekend, before we embark on a run of games which sees us face Palace (who'll be without Mamadou Sakho thankfully), Watford, Southampton, West Ham and Middlesbrough. Our final two games may be vital to the relegation battle, which is when you can throw form out the window, but we should be confident in all nonetheless.
It's vital that we pick up no more injuries, as with Jordan Henderson, Adam Lallana and Sadio Mane all currently out, the team is threadbare as it is.


text:
Contact Me.
Say "Hello" - it'd be great to connect.
I always have my mobile with me (I take photos ALL the time!) so you can leave a message if I don't pick up straight away.
You can contact me on 07766-145068 or email me at email@example.com.
I'd love to connect with you!
- firstname.lastname@example.com
- 07766-145068
- Lelant, St Ives, Cornwall, UK


text:
MSNBC's The Rachel Maddow Show attains The Best Rating Ever in 2016!
Quick Information
- Date of Birth 1973-04-01
- Age 47 Years 6 Month(s)
- Nationality American
- Profession Television Host
- Birth Name Rachel Anne Maddow
- Zodiac Sign Aries
- Ethnicity/Race Mixed
- Father Bob Maddow
- Mother Elaine Maddow
- Brother/s David Maddow
- Children/Kids Not Yet
- Relationship Status Dating
- Divorce/Split Not Yet
- Partner Susan Mikula (1999 - present)
- Salary $7 Million Per Year
- Net Worth $20 Million (Estimated)
- Career 1973–present
- High School Castro Valley High School
- College Oxford University (2001)
- Height/ How Tall? 5'11" (1.80 m)
- Weight 68 kg (150 lbs)
- Hair Short
- Hair Color Black
- Eye Color Black
- Lesbian Yes
Cable News T.V anchor, Rachel Maddow received the highest rating this year in "The Rachel Maddow Show" beating CNN and Fox News by most viewers in comparison. This marks a seven-year streak in the twenty-year history of MSNBC attaining the best ratings ever in 2016 and still the most viewed cable news channel.
Caption: Rachel on set "The Rachel Maddow Show" in December 2016.
Picture Credit: thewarp.com
"The Rachel Maddow Show," is a political cable news channel in MSNBC with its host Rachel Maddow herself, as the anchor. The 43-year-old political analyst and reporter have had a good year with her improved view rating. Not only its view-rate is affected, but the show has grown more in a year in comparison to other competitive news networks such as CNN and Fox News. This news program rose by a one hundred and fifteen percent in A2554 and a seventy-two percentage in total viewers, marking the show as the highest-rated compared to last year. Last year the show gained an eighty-seven percentage in total prime time viewers and a ninety-seven percent in the prime time demo in 2015.
A Short bio on the construction of "The Rachel Maddow Show."
Rachel Maddow was a substitute host when she first joined MSNBC in 2008. Very successful in attracting viewers who were aged 25 to 54 led to Rachel's employers to offer her a show replacing Verdict with Dan Abrams in the 9 pm slot in August of 2008. In the following month September 8th, Rachel first debuted her show, "The Rachel Maddow Show."
Aside from her work, her personal life is not to be missed as Rachel is currently staying with her long termed girlfriend, Susan Mikula.


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The best way to knock something out quickly is to know what you're doing and be organized. Outside of that, the best way is to read the instructions and be organized. I chose the third option, read the instructions and having nothing ready. This is why the 15 minute strut tower brace install took me 30 minutes.
Selecting your strut tower brace
I ordered my strut tower brace from speedlogix on black friday. The piece I got is a 4 point strut tower bar, least expensive 4 pt I can find. I would highly recommend this over going with a less expensive 2 point. Basically, when you're trying to stiffen your chassis, you want more than just 2 points linked together, right? Don't get me wrong, a 2 pt will help, but unless you've got a compelling reason, then a 4 point is the way to go.
Disclaimer: This is based on you having a gutted interior on the car already. If you need to remove interior panels, this will take you a little longer, but basically, pop the rear seat, take off the side and bottom panel in the trunk, and then move forward.
Other disclaimer: I am not an ase certified mechanic, but I'm also not a novice to this stuff. Torque specs exist for a reason, over-torqing is a great way to damage things. DON'T DO IT. If you don't have a torque wrench, there are plenty available out there, sometimes for quite cheap. If you can't afford a torque wrench, but you have a strut tower brace on hand, do yourself a favor, sell the strut tower brace, use the money to go get this torque wrench. Use the leftover money to buy a consolation beer and start up a new strut tower brace fund.
Getting organized
Things you will need:
Strut Tower Brace
18mm socket
15mm socket
Torque wrench
Gutted interior
Getting Started
Step 1 – Make sure your strut tower brace is inside your trunk, then carefully unwrap it. Little dings here and there wont compromise its structural integrity, but you don't want anything to rust.
Step 2 – Gently place the strut tower brace on top of the strut towers, line up all the holes, and then ensure the central portion (if present, e.g. 4 point brace). Is on or as close to the forward mounting point (center, rear seat, 2 MASSIVE studs which will take our 18mm nuts) as possible.
Step 3 – Move to the rear seat area, work the brace and any obstacles (such as an aluminum rear firewall) until you can get the slots in the brace lined up properly with the studs, and slid all the way down (try to minimize potential damage to the threads during this step).
Step 4 – Lightly hand tighten the 18mm nuts onto the studs in the rear seat area.
Step 5 – Move to the trunk, place the provided spacers (razors edge documentation calls them 'cups') open side down over the existing nuts on the strut-bolts (these should be the two smaller studs on either side of the strut).
Step 6 – Lightly hand tighten the 15mm nuts over the top of your spacers (cups).
Step 7 – Grab your torque wrench and tighten everybody in the trunk down to about 10-15 ftlbs of torque.
Step 8 – Move to the rear seat, tighten the nuts down to 42 ftlbs of torque. DO NOT OVERTIGHTEN
Step 9 – Move back to the trunk, tighten everybody down to 32 ftlbs of torque. DO NOT OVERTIGHTEN
Step 10 – Doublecheck everybodys torque level and go for a drive.


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Planning a wedding or any special event is a great responsibility, stressful and enjoyable! The experienced Event Planners at Culinary Village Catering help you navigate this process with effortlessness.
It is our pleasure to create a Custom Wow Factor Menu tailored perfectly for your palate, reasonable and affair. Our Experienced Coordinators and Planners consult in-person or over the phone about your dream and concepts, drawing inspiration from your favorite foods and restaurants, event goals, and personality. We can even assist you with selecting a location that is picture-perfect for your vision! Your Experienced Coordinators/Planner can offer unique insight into your venue and event setup, ensuring your reception flows well and can be executed to your specifications. Once your Planner understands your personal goals, tastes and limits, they create a Proposal for your special event.
Once all is agreed and you are ready move forward with Culinary Village Catering and placed your deposit, the real excitement begins! Full-service event menus are confirmed through a Tasting with our chefs. The tasting is an chance to preview selections from your custom menu. We know tastings are vital to providing you with the best service and experience. We do this because we want you relaxed and confident that your guests will receive impeccable service and restaurant-quality cuisine!
After your tasting, your Planner will stay in contact with you, your venue and vendor team to ensure a smooth planning process. Seven days prior to your wedding, your Planner will confirm all final details including guest counts, seating arrangements, and any special meal considerations. When your big day arrives, all the details will be set in stone and you are free to enjoy your wedding day!


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I authored the post, and yes, most of these techniques were actually developed working on a mobile VR game. After mobile VR, we assumed regular VR would be easier - but we ran into just as many performance issues, just in different ways.artrynk said:What can I say))) try work in mobile project and VR become very easy )
Bobbert said:Does the amount of roughness in a material really contribute to shader complexity in a deferred renderer? Or is this project using the engine's forward rendering path for VR? That alone would be an interesting distinction for the author to note.


text: Here you go Xeo ...found himself on the way to the roof of the building. He could make out no movement on the horizon, or anywhere for that matter. The roads were silent, the buildings lacked all life and the grounds were devoid of anything in the nature of human life. Indeed, there was nothing on the streets except more dead bodies and wreckage. He took a deep breath and closed his eyes, planning his next move. A siren started to blare somewhere. He opened his eyes after taking a few more breaths. There was work to do, he knew, before he could establish communications with the outside world. It was about to get dark, and he wanted to get something done before darkness fully stretched itself over the land. The siren kept blaring.


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This is the first time I did the lash perm and although it only partly turned out right, makeup fixed it. So in this post I will share how I did it, what went wrong, and how I will do it next time.
I purchased on Amazon this lash perm kit. It's the one that was available to order in India, and I had to wait for exactly two weeks for it to be delivered as it was sent from abroad.
So when I got it yesterday, I was beyond happy. I was growing my eyelashes with castor oil by applying it before sleep mostly every night unless I would forget to do that.
Some claim there's no research to prove that hair grows more because of the castor oil application. There's no research because there's no profit in doing such research unlike for patented drugs. But the feedback of people who experienced hair growth is overwhelming. Just read any review of good castor oil to know this.
So as a result of nightly application of castor oil I saw great lash growth, and my plucked out eyebrows are also growing back, though very slowly and now I only see baby hairs.
Since I saw significant lash growth, I could not wait to get them permed because they are naturally very straight and no curler ever is able to curl them even for a minute.
The day I got the eyelash perm kit, I took a shower because I knew that the eyelashes should not be gotten wet for 24 hours ideally after the perm. Then I read the instructions, read the tips and feedback of people who purchased this kit on Amazon, saw several DIY lash perm YouTube videos, and I got plenty of Q-tips for the procedure.
I followed the instructions at the back of the lash perm kit. The pink plastic-gum pad just wouldn't stick to my eyelid. And then when it did, after some time it would come off.
I had to spend ages to glue my stubborn eyelashes to the pad and they ended up coming off during the procedure. So during the perm application I had to hold my lashes with the Q-tip with the tip cut off, which I used for the application of the liquids of the kit and the separation of lashes from each other.
This is the reason my eyelashes turned out different for each eye. That pink pad kept coming off. I had to redo one eye to make the results a little bit more even, and this time I used the adhesive white strips that also came with the product:
When I was applying the perm to my second eye, I think I applied the perm right on the root which resulted in slight stinging in that area, but I ignored the pain. The eyelid of that eye therefore got inflamed somewhat, I saw a raised line right above my lashline and I felt stinging in that area until I fell asleep.
But it was that eye that ended up looking great (my left eye) whilst the lashes of my right eye weren't as curled. So when I'm without makeup, I see the left eye lashes more curly, but thankfully makeup fixes this issue because as a result of perm the eyelashes are very flexible, so I get extra curl with mascara which I wasn't able to achieve in the past even after using a curler.
So in the picture my right eye has no mascara at all – it just got some color from my eyeliner. Whilst the right eye has quite a lot of mascara! You can't tell this fortunately, and this gave me such a relief as I don't want my eyes to look different from one another!
I'm definitely going to do this procedure again, but I learnt that I should never use the pink plastic-gum pads which don't stick at all, but go with the self-adhesive pads which get my eyelashes easily stick to it yet it gives no chance to fix individual lashes as it instantly makes them glued to it.
The picture above is one a few first pictures I took so far, as I'm in a cafe now so I don't want to take multiple pictures of myself for people to think I'm obsessed with selfies:) But I think it shows the result very well.
I think my left eyelid is still somewhat swollen but it's now throughout the eyelid and it's a smaller swelling than after the procedure. The eyelid is still somewhat sensitive but no longer painful.
Next time I won't be applying the perm right on the lash line but just above it, as I don't want to get this problem again. Also, it's better not to apply the perm solution on the tips of the lashes so that you don't get them burnt the second time you do the perm.
Since, as I've already mentioned, the lashes of my right eye weren't as curled, I took the self-adhesive pad and put some of the lashes on it (the ones that weren't that curled), applied the perm again for seven minutes, removed it, and applied the setting lotion, following identical steps as outlined on the kit.
This shouldn't be done though, because your lashes can get burnt. But I didn't have much choice as I wanted the eyelashes of both eyes to look more similar.
It did give some lift to the lashes the second time I did it, but nothing significant. Fortunately, as I said, mascara fixed it, as now the lashes are very moldable so mascara gave them the required lift.
To further fix the result, I applied castor oil on the left eye before sleep (castor oil can somewhat straighten the permed lashes) and I also slept with a scarf on my eyes (that's what I do usually, as I leave a small light on when I sleep) and I put pressure with the scarf on the left eye so that it's less curled.
When I woke up, I noticed the lashes of my right eye no longer touching my above crease. So again, the result became a little more even for both eyes.
Since the eyelashes are so lifted, when I did my makeup I had to put some eyeliner between the eyelashes, below the upper lashline. Sometimes I see this uncolored area in women who have the lashline naturally lifted, and it doesn't look good. The eyeliner fixed this small problem.
In general, I'm very happy to have done this procedure, and I will do it a month or so later again, this time with some lessons learnt. Since castor oil made my lashes much longer, it's waste not to have them be seen!
In fact, if I put mascara on my straight lashes, it makes my eyes look smaller. But with curled lashes, it opens my eyes, makes them look sharper (whatever that means – these are the words of my boyfriend) and more expressive.
So I'm happy to have tried this procedure, and although it didn't produce a perfect result, makeup fixed it and I learnt from my mistakes. So hopefully the next time I do this the result will be much better.


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Consumer wearable devices -- including fitness trackers, smart glasses, and smart watches -- will have shipped 64 million units worldwide by the end of 2017, according to a new report from Berg Insight. That's up from 8.3 million in 2012 and 3.1 million in 2011, a compound annual growth rate of 50.6 percent.
Berg predicts smartwatches will eclipse fitness trackers, the current leaders in the category, to become the largest wearable segment. The report says smartwatches will make up 23 percent of the 13.8 million cellular connected consumer M2M devices that ship in 2017, while personal trackers will make up 17 percent.
"A perfect storm of innovation within low power wireless connectivity, sensor technology, big data, cloud services, voice user interfaces and mobile computing power is coming together and paves the way for connected wearable technology," Senior Analyst Johan Svanberg said in a statement. "However, today's devices need to evolve into something more than single purpose fitness trackers or external smartphone notification centers in order to be truly successful."
There's some debate as to how the two markets -- smartwatches and activity trackers -- will shake out. Berg believes smartwatches will incorporate fitness tracking functionality, something that's already begun to happen with the Samsung Galaxy Gear smartwatch, which includes several fitness apps, and the Pebble Smartwatch, which sports Runkeeper integration.
On the other hand, when we spoke to tracker makers like Basis CEO Jef Holove for our fitness tracking podcast, they said they weren't worried about that competition, since smartwatches mostly just relocate the smartphone experience to the wrist.
"We just don't believe the big idea for wearables is to duplicate a user experience and kind of move it around," Holove told MobiHealthNews in April. "We think the big idea for wearables is bring real incremental value from the fact that you're wearing the technology and that means the technology is in contact with your body, and, in our case we're taking advantage of that to deploy sensors that learn a lot about your body... I think smartwatches are likely to include accelerometers for sure, so they'll be able to track activity levels just like devices with accelerometers can do today, but obviously our aim is to do something much more fundamental, much more insightful than that."
In February of 2012, a report from ABI put the number of health and fitness wearables in 2017 at a much higher 174 million, although that number included 80 million medical wearables, which Berg's numbers exclude. Just this week, ABI projected that the wearable market would hit $6 billion in 2018, and that 13 million wearables would be used in the corporate wellness sector alone.


text:
40% off your first order & free shipping on $35+ when you select Repeat Delivery in cart!
Attributes / Specifications
Additional Details
Petmate Programmable Pet Feeder
- Portion controlled
- Large LCD screen
- Programming is easy
- Twist-lock lid that keeps food fresh
- Primary BrandPetmate
- Days to ShipShips Next Business Day
Our Petmate Programmable Pet Feeder provides your pet with a continuous supply of food throughout the day.The Petmate Programmable Feeder is not only reliable in delivering portion-controlled meals to pets while the pet parent is away, it also eliminates the daily chore of scooping & measuring. With a large LCD screen & built-in meal counter, programming is easy, with 3 simple buttons that take the pet parent through the process. The food hopper is conveniently transparent for monitoring food levels at a glance & has a handy twist-lock lid to keep the food fresh & secure. The bowl is removable for easy cleaning & is top-shelf dishwasher safe.