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Caldwell & Associates will partner with your leadership team to get your workforce safely to "the other side" while producing the highest quality products and services for the customers. The other side comes when there is a vaccine or treatment for the Coronavirus COVID-19 that is disseminated throughout the U.S. and the world.
Caldwell & Associates LLC provides and transfers Operational Excellence to small and medium-size companies through the Shingo Model and Safe Lean Six Sigma consulting, training, and coaching. C & A will partner with your leadership team to getting your workforce safely to "the other side" while producing quality products and services for the customers. We specialize in Operational Excellence (OPEX) and Critical Business Problem Solving (CBPS). C & A is comprised of independent Certified Master Six Sigma Black Belts/Lean Sensei practitioners, with 90 years of experience, including international experience. Our principal consultants are proficient in Lean and Six Sigma. We are "Special Forces Problem Solvers" for our customers. We are dedicated to providing our services with integrity, efficiency, effectiveness, and honesty.
Rely on our consultants, for the consulting, training, coaching, and mentoring of your employees! If you're wondering, "Where can I find an effective business consultant?" contact our consultants today.
Contact Us
Dr. Shingo, born in Saga City, Japan, was a Japanese industrial engineer who was considered as the world's leading expert on manufacturing practices and the Toyota Production System. Few individuals have contributed as much to the development of the ideas called TQM, JIT, and Lean as did Shigeo Shingo. Over the course of his life, Dr. Shingo wrote and published 17 books, eight of which were translated from Japanese into English. Many years before they became popular in the Western world, Dr. Shingo wrote about the ideas of ensuring quality at the source, flowing value to customers, working with zero inventories, rapidly setting up machines through the system of "single-minutes exchange of die"(SMED)*, and going to the actual workplace to grasp the true situation there ("going to gemba"). He worked extensively with Toyota executives, especially Mr. Taiichi Ohno, who helped him to apply his understanding of these concepts in the real world.
The Shingo Model booklet is free to download and will teach you the basic concepts.
Greg has over thirty years of manufacturing and engineering experience in the Aerospace and Automotive industries with GE Aircraft Engines, Ford, Coolant Control, and Lean Continuous Improvements. As a Senior Plant Manager, he leads The Ford Production System in multiple sites in North America and worked two years in Tokyo, Japan, with senior management building the joint venture between Ford and Mazda. For his efforts, he received twelve Managerial Awards of Excellence and three Departmental Managers Awards. Greg graduated from Colorado State University with a Bachelor of Science in Mechanical Engineering while earning two All-American Football Awards with a 3.97 GPA. He played in the NFL for four years with the San Francisco 49ers and New England Patriots. He is a certified Professional Engineer, Six Sigma Master Black Belt, and Lean Sensei. Greg is President and CEO of Lean Continuous Improvement LLC.
Andrew Lux Ph.D. is an Operations and Technical leader with extensive experience in overseeing and directing global operations within Class II and Class III medical device and pharmaceuticals manufacturing firms. His expertise ranges in leading business transformations (turnarounds), coordinating and leading strategic acquisition, business development transactions and revenue growth strategies for startup and midsized companies. His background is in directing companies ranging from start-ups to multimillion-dollar global business, including divisions for Johnson & Johnson, GE, Medtronic, Baxter, and others. He is skilled at building new operational infrastructures or turning around underperforming facilities to drive exceptional growth for expansions or position for acquisition. He has successfully implemented world-class manufacturing programs using Lean Six Sigma processes at J&J, Medtronic, GE and Baxter. Because of his technical background he has been repeatedly sought out to help maximize operational performance within engineering, quality, and operations functions. He has taught Courses in Operations Management, Statistics, Material Science, Lean Six Sigma, Business Development & Entrepreneurship. Andrew has MS and PhD from Massachusetts Institute of Technology, MBA from Case Western Reserve University, and a BS from Cleveland State University. He holds certifications as Lean Six Sigma Master Black Belt and Quality Systems Manager. Andrew is Founder and President of JL Enterprise Group Inc.
RC has over thirty years of management, engineering, and manufacturing experience from Johnson & Johnson, General Motors, Goodrich Aerospace, Cintas, and Sinclair Community College in the United States, Europe, Mexico, Canada, and China. He led the Global Supplier Excellence Partner Development group that resolved critical quality and capacity problems at strategic suppliers. His expertise is in assisting and guiding companies with the transformation of their organization to world-class excellence through product innovation, Lean Six Sigma improvements, and self-directed teams for superior products and services. He was an Associate Industrial Engineering Technology Professor at Sinclair Community College for eight years. RC is certified as a Lean Six Sigma Master Black Belt, Six Sigma Black Belt, and Lean Sensei. He has a Bachelor of Science in Industrial Engineering from the University of Cincinnati and a Master of Science in Human Factors Engineering from Wright State University.
Contact us if you have Operational Excellence or Lean Six Sigma questions that you need answers. Your first consultation is free. We will provide you with Operational Excellence or Lean Six Sigma answers that will lead to safe and better results. To get your answers, please fill out the contact form below.
Thank you for your interest. We look forward to hearing from you soon.
Phone(937) 367-6743
Service AreaServing throughout the United States, Canada, and the Caribbean (English).
Caldwell & Associates LLC


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Using Value Sources on some Quantity fields
This can mainly be used for crafting and auctioning. Now we can use value sources data as quantities like daily region sold.
It can be useful to automatically assign them to fields like "restock quantity" or "post cap".
That way we'll have a way to dynamically craft/buy/sell based on a number representative of each item. We would be able to apply a formula (for instance 0.1*avgdailysoldquantity)
Obviously TSM would round the value source and there will have to be a default value in case the value source is undefined.
Planned for TSM4.10 – Gumdrops
1 comment
Lurker commented
Yes, please! I'd love to use things like DBRegionSaleRate and DBRegionSoldPerDay in things like Vendoring and Crafting Operations to filter out items without having to go manually filter and put certain things into sub-groups.

subset: commoncrawl


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Carbonated water beverage
The World Gourmet Summit that can place at the hippest area Singapore is the most awaited culinary arts event that attracts holidaymakers chefs and winemakers from across the world. Travel through business class flights to Singapore and experience the matchless culinary creations by the worlds renowned chefs.
The melting stage of several cultures Singapore offers one common ingredient that brings every individual to one stage. The World Connoisseur Summit an annual renowned culinary event associated with Singapore where worlds well-known chefs present an selection of delectable discoveries is probably the greatest food fairs. The gastronomic summit appeals to foodies from the world over that travel through several international airways to enjoy the actual extraordinary wines along with appetizing dishes served during this festival. Carbonated water beverage
Entire world Gourmet Summit in which commences from 25th April 2011 can embark 15 years from the food festival. In promoting this alluring function several airlines shall offer discounts on air flight for you to Singapore. There are few international air carriers that often offer discounts on business aircraft to Singapore during this event. Organized by Knipp Holdings Pte Ltd and also supported by Singapore Tourism Board the festival invitations celebrity chefs which prepare delicious designs and present the spectacular wines to all people.
Those who have an obsession for food frequently book air seats to Singapore well in advance to have a truly and amazing culinary experience. Many venues such as The Lavish Hyatts Mezza9 The Fullerton Hotels The actual Lighthouse Grand Copthorne Waterfront Singapores Pontini Fairmont Singapores Inagiku as well as St Regis Singapores Brasserie Les Saveurs organize food festivals where by visitors savor this fine cuisines prepared by the celebrity culinary experts.
Established in 1964 the World Gourmet Festivity also offers several activities such as special culinary workshops arranged with the celebrity chefs yummy wine tasting and also table luncheons and similar people that are organized for you to entertain the holidaymakers and guests. The actual airfares of the business passes and other coach class air tickets typically go on sale with this marvelous festival. Website visitors with perpetual fervour participate and feel the extraordinary gastronomic journey.
The festival is not only important for the renowned cooks but also sets a platform for the wine beverage makers who travel from the world over to show their wines. Wine producers from the wines producing regions such as Bordeaux Burgundy Tuscany Spain in addition to Australia visit Singapore in which a vertical tasting in their prized pours is finished. Travelers also enjoy the exotic drinks offered by several airlines to the passengers who publication business class seat designs for their air travel.
To be able to celebrate its gem anniversary the peak will invite a particular chief guest and also a shining cast associated with celebrity chef and also master chefs becasue it is privileged guests. Go to Singapore and awaken your own senses at the premium festival by reserving business class oxygen flights to Singapore. You may even make your reservations together with Fare Buzz one of the main travel companies with United States that offer savings on business category tickets and coach class air flight tickets to Singapore and several vacation spots across the world.
Floresbrowns is an link editor of FareBuzz. The website offers exclusive facts related to air range flights and air plane tickets. We likewise have online reservation for reasonable business class aircraft Cheap hotels Rental-car and vacation packages. Wes thank you for feedback and questions at flores. Carbonated water beverage Wine cabinets are important pieces of equipment for that wine lover inside so many ways. It is really an excellent way to retail store bottles of wine without studying the time effort and funds to build a wine cellar not to mention that that lends beauty towards the mini-bar. In the process of purchasing 1 you will encounter wine rack reviews.
What These are generally
Simply put reviews associated with racks pertain to the specific experiences impressions and also opinions of the customers regarding particular makes and models of the products. Most of these reviews are provided by the average consumers exactly who actually made purchasing and actually used this product in their homes or offices.
A few of these reviews were produced by professional reviewers in this these individuals were settled by an independent research organization to write factual reviews of the goods after a certain duration of use. You will also come across rack reviews that will suspiciously read like promoting hype but this really is to be expected while everybody is allowed to employ one form or another of advertisement within just legal limits.
Finding Them
Reviews regarding racks can be found in many venues. You have websites on the internet that sell wines racks that are next rated or examined by the buyers on the products. Usually there is absolutely no format used for this reviews although you will see instances when these solution evaluations are coded in pros cons conclusion in addition to star rating format.


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Album Review: People Of Nothing by People Of Nothing
People Of Nothing released their self titled album at the start of the week, the work of French guitarist Florian Chombart, the album is a ten track dark wave opus. Haunting and invigorating in equal parts People Of Nothing is joy from start to finish.
It's always handy to have a genre as a point of reference, with People Of Nothing it's a difficult task. If I were to draw a Venn diagram the circles for post punk and 80s style new wave would have equal parts, while jostling for position with sinister dark wave, experimental rock and electronica. Without doubt it is a complex mix, but one which works extremely well.
The haunting introduction of 'Hold' is superb, the electro beat is poignant with Chombart's vocal coming over with a hint of Ian Curtis. The refined guitar bursts in just after a minute and a half is excellent, bringing an excellent surge of energy. The post-punk bluster of 'Haircut The Grass' is executed with aplomb. It wavers between moments of raw energy and evocative interludes. Fantastic stuff.
People Of Nothing then goes from strength to strength, but what is most notable is the fact that it's the work of one man. Entirely written, composed and arranged by Florian Chomart. Undeniably a work of genius, you'll be blown away by the vastness of each track, you'll notice little new features with each listen.
'My Stain' has a lovely bass groove. Laid back with some delectable soaring guitars it has the makings of an end of party anthem. 'A Break To Cry' has another fantastic electro introduction before the sinister post-wave guitar takes over creating a wonderful atmosphere. 'Unforgettable' is exactly that, there's a garage rock style element there, coming out akin to something The Strokes always aspired to write but never quite reached that point. It's probably the most accessible track on People Of Nothing, the guitar riff that kicks off at 2minutes 20seconds is simply fantastic – raw and full of impassioned energy.
'Love Action' is a lovely piano led track, gentle and sombre your heart string will be firmly tugged. 'Hour Days' may be the final proper song on the album (with the final two tracks being remixes) and as a closer it would do a fine job. A perfect example of People As Nothing's ability to blend haunting energy and a chilling yet invigorating punk energy.
People Of Nothing is a superb album, blending a realm of genres resulting in a work of genius.
AD Rating: 9/ 10
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Sunraysia Motel
Hotel Rewards - Motel - Boutique Hotel - Cheap Hotel
Budget Hotel - Hotel Guide - Hostels - Hard Rock Hotel
Listen to Coronavirus Patient Zero
Portsmouth City Guide, Including Hotels
Introduction: Portsmouth is located on the south coast of the scenic county of Hampshire. The city has a long established historic naval presence. The city of Portsmouth was established in the year 1623, being a community that swears by its influence to world history. As well as being an important naval town, Portsmouth has a nostalgic feel with it's cobblestone streets, horse drawn carriages, museums and famous historic buildings. Boasting over one hundred restaurants, antique shops and a huge music hall called the Portsmouth Music Hall. You will fall in love with the ambience that this historic city offers as well as the coastal aspect of the place.
Places of Interest: A place of historic significance, you can explore Lord Nelson's flagship, HMS Victory and visit Queen Victoria's battleship, HMS Warrior 1860. You could also have a look at Henry Vlll's Mary Rose and retrace the history of the Royal Navy at the Royal Naval Museum. Other attractions include Charles Dickens' birthplace, the D-Day Museum featuring the Overlord Embroidery, Southsea Castle, the Royal Marines Museum, and Portsmouth Cathedral. Royal Marines Museum: This is a grand museum situated in a former officers' mess with sweeping stairways, chandeliers and fine paintings. There are also beautiful grounds in which you can relax and enjoy a quiet picnic with your friends.
The Exhibition gallery features a talking head of Hannah Snell, audiovisual shows, interactive games, and a collection of over 7,000 medals. Eastney Beam Engine House Industrial Archaeology: This museum contains a pair of magnificent James Watt beam engines, stationed in their original high Victorian engine house of 1887. There are also a variety of other pumping engines on display here. Natural History Museum: In this museum you can see the geology of the Portsmouth area and a full-size reconstruction of Dinosaur "Iguanodon" and other fossil remains. You can enter here through the Riverbank scene with a fresh water aquarium and have a look at the different kinds of fish on display. You can also see the "Ice Age" displays and early mammals and birds here. The Spinnaker Tower: This is one wonder which is absolutely breath-taking.You can experience the stunning views from this unique 170m tower, visible from miles around. This is the newest landmark which is change the skyline of Portsmouth! Aspex Gallery: Here, tourists can experience the most creative and contemporary visual arts; locally, nationally and internationally. There are programs of solo, grouped and themed exhibitions mostly centred on the work of younger or emerging artists.
The 1642 Living History Village, Historic Site, Gosport: This is a representational Hampshire village set in the year 1642. You could go back in time and experience this replica of how it used to be with timber and thatched buildings. Occupants dress and speak in 17th century style. Things to do: Portsmouth is also called the Waterfront city. It has a fantastic range of restaurants, bars and cafés to soothe your thirst and satisfy your taste buds. Of course, it will suit your budget too. As far as shops are concerned, the choice is huge. Shopping: The Southsea, this major shopping complex has two department stores as well as a range of boutique shops. There are florists, diamond merchants and antique dealers; even interior decorators to cater to your every shopping need. Of course, the cafes, restaurants and bars are numerous too.
There is Gunwharf Quays with 80 outlets that sell big brand names for a discount prices. It is open seven days a week. The City Centre is famous for it's branded and trendy stores. The shopping precinct on Commercial Road, the indoor mall at Cascades, and the street markets on Thursday, Friday and Saturday are very popular and well worth a visit. Eating and drinking: There are restaurants and small bistro's that offer cuisine ranging from Indian to Italian, Turkish to Thai. If you want to meet with friends or enjoy your weekend, there is always a themed location to drink and socialize. Special Events: Two of Portsmouth's most renowned personalities have events to commemorate their lives in 2006. "Brunel 200 Portsmouth" will celebrate the 200th anniversary of the birth of Isambard Kingdom Brunel, who was born in Portsmouth on 9th of April 1806.The famous author Richard Lancelyn Green will be releasing his wonderful collection of Conan Doyle-related books, papers and assorted memorabilia in the later half of 2006. Transport: Portsmouth has regular bus routes connecting the main visitor areas.
In fact, a new pilot bus service for all you night owls has been inaugurated and is operational on Friday and Saturday nights. The Nightrunner will start services from South Parade Pier at 1.25am and 2.25 am and at Winston Churchill Avenue at 1.30am and 2.30am. There are currently 234 licensed taxis working in the city providing 24-hour service. Food and Drink: Indian Palace: Indian Palace in Gunwharf Quays is famous for authentic and traditional spicy and tasty Indian and moghlai dishes. Arbuckles: This small and friendly restaurant is famous for chicken and vegetarian burgers.
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Roll Off Container Service Company Denver
Mile High Roll-Off is a roll off container service company in Denver providing straight-forward honest service to each and every one of our clients no matter! We're very proud of our business as we help our clients get the roll off containers they need for all construction, demolition, clean up and more projects. We are a reliable roll off company to call whenever you need a roll off container delivered and we make it that much easier as Mile High Roll-Off as your choice.
Service is key for the team at Mile High Roll-Off because we want clients to have a good experience through and through. We are confident you will be grateful that you called us at Mile High Roll-Off to schedule our roll off container services this year. Were a trusted name all across Denver to get a reliable dumpster container delivered where and when you need it. Will always pick it up when you're done and haul it to the dump for you. Is all part of our roll off containers services standard.
Choose a trusted roll off container service company such as Mile High Roll-Off help out with your upcoming waste removal projects all across Denver. You'll be glad you called us at Mile High Roll-Off.


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SALT LAKE CITY -- Varian Medical Systems congratulates Mobius Imaging, LLC, on receiving two prestigious and internationally recognized honors for its AIRO® Mobile Intraoperative CT system: a 2014 Red Dot Product Design Award and selection as a finalist in 17th annual Medical Design Excellence Awards competition. Varian supplies Mobius with the high performance X-ray tube that powers the AIRO system's intraoperative CT imaging.
The AIRO integrates advanced imaging technologies into a compact, mobile CT system that offers procedural flexibility and real-time imaging where and when it is needed. The AIRO system is small and maneuverable, yet offers a large gantry opening, making it ideal for intraoperative imaging. It incorporates a variety of custom components, including a specially-designed lightweight, compact X-ray tube from Varian.
"Our AIRO mobile CT imaging system can be moved from room to room in the hospital; it's not bolted to the floor in radiology like other conventional CT systems," said Gene Gregerson, president of Mobius Imaging. "The challenge was to make it both big and small—big enough in the middle to accommodate larger patients and immobilization devices, and small enough in terms of outer circumference to be mobile. So we made the ring very narrow; it is only about 10% of the volume of a typical CT scanner ring. That left very little room for the X-ray tube. Varian developed an amazing piece of technology for us, and it is a key component that makes the system possible."
"Gene came to us with an idea about how to develop a next generation mobile CT system for the operating room," said Stephen Kimmel, executive vice president of sales and marketing for Varian's Imaging Components Business. "Mobius wanted a system with no compromises, and this required many new inventions. There was no X-ray tube on the market that came close to the specifications Mobius needed; everything was too large and heavy, and would not fit into their gantry."
According to Kimmel, Varian had been working on a project to take its patented anode end-grounded X-ray tube design, which produces tubes that can run cooler and last longer, and adapt it for the mid-tier tube market. "We agreed to expedite the project and so Mobius became the catalyst for the development of what is now our new FP1000 CT Tube," he said.
The AIRO system, with its FP1000 CT tube, won a 2014 Red Dot Product Design Award in the Medicine and Life Science category. The Red Dot organization, which is based in Essen, Germany, awards prizes annually for product design, design agencies and design concepts. This year, a jury of 40 accomplished designers and design experts from across the globe evaluated over 4,800 products that were submitted by designers and companies from 53 countries. The winners were announced in March.
The AIRO was also selected as a finalist in the Radiological and Electromechanical Devices category of the 17th AnnualMedical Design Excellence Awards competition. Finalists were officially announced in the April Issue of MD+DI (Medical Device and Diagnostic Industry) magazine. Winners will be announced at the 2014 MDEA Ceremony on Wednesday, June 11, 2014 in conjunction with the MD&M East event at the Jacob K. Javits Convention Center in New York.
"Being selected as an MDEA finalist is a testament to the skill and innovation of the Mobius design team, which took this product from a design concept to an FDA-cleared device said Caldes. "We're pleased to have played a role in this well-deserved recognition that Mobius is receiving for an impressive system that could potentially make significant contributions to improving medical outcomes and assist with reducing medical costs."
More information about the awards and a list of winners can be found at http://www.red-dot.org
For more information, visit http://www.varian.com


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Dishwasher (per diem)
Overlake Hospital is currently seeking a Per Diem Dishwasher to join our excellent hospitality team. Responsible for service excellence relative to ware-washing, pots/pans washing, trash/recyclables/compostables management, floors, walls, disposal containers, special project cleaning, floor mats and general cleaning of kitchen/cafes as assigned.
Per Diem - Variable Shifts
- Maintain scullery room inclusive of daily dish-machine breakdown and cleaning.
- Wash pots, pans and kitchen utensils in power soak sink, finishing off in main dish-machine. (Use 3-compartment sinks process to clean when machine is out of service.)
- Maintain proper clean storage of all kitchen pots, pans, utensils, china, etc.
- Clean all trash, recycle, compostable and transfer carts weekly inside/out.
- Wash floor mats daily.
- Pull equipment on wheels out weekly to clean behind properly.
- Wash walls, ceiling vents, and assigned projects monthly.
- Clean and stock all hand-washing sinks daily.
- Sweep and mop floors daily.
- Clean special equipment as requested.
Education/Required Skills:
- Ability to communicate in English effectively required.
- High School Diploma preferred.
- General computer (Microsoft Office) knowledge preferred.
Professional License/Certification/Registration:
- King County Health Card Required
Experience:6 months environmental services related work preferred
Just a few of our employee perks
- Cell phone plan discounts
- Discounted Mariners and Sounders tickets
- Computer discounts
- Discounted lift tickets
- Discounted movie tickets
- Discounted gym memberships
- Free Seattle Art Museum passes
- And much more
The community you will join
At Overlake, we believe exceptional patient care comes naturally when our staff feels respected, valued, and cared for. So we've cultivated a culture that feels like a community. In fact, we're more like a great big family. Our people will always be there for you. Our supportive environment and team of passionate professionals have earned the hospital its reputation as a healthcare leader in the region. We are truly committed to providing compassionate, high-quality patient care in a progressive and collaborative environment.
Overlake Hospital is an Equal Opportunity Employer


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Renovations work
Over the years we have built up experience and many skills working on renovations with older properties. Our aim is always to maintain as much of the original features as possible, whilst modernising the property to a much more current layout and specification.
We have experience working with traditional lime mortars and renders if the property needs to be kept to original specifications.


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Subtle heathering and cable detail will add a refined touch to every home décor. Made from our shorter pile Cozychic knit, it is the perfect, lightweight blanket for lounging.
Designed and Produced byBarefoot Dreams Productions
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Your Order when you sign up for exclusive offers, event invites, new arrivals & more.*
* See sign-up confirmation email for details.


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Have Fun With Online Games!
Do you need a few minutes break in the office? Or do you want to have a nice time when you are feeling bored at home? Well you now have the option to play video games on your computer! With … Continue reading
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Online Gaming World
Online games are one of the best sources of entertainment for children. There are several types of online games that are fashioned to suit kids belonging to different age group. Car racing is one of the most popular forms of … Continue reading
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Jump to navigation
Governments in Canada at all levels have frequently used the law to censor the pro-life message. In 2018 for example, both Alberta and Ontario passed legislation to make it illegal to protest abortion near abortion clinics. In Calgary, we are now seeing attempts from the City Council to censor Canadians' rights to peacefully assemble and stand up for the unborn.
Barclays Bank has unilaterally decided to withdraw banking services to one of their customers, a Christian organisation, the Core Issues Trust (CIT), following pressure from high-profile LGBT activists. While no official explanation has been given, it seems as though Barclays are following in the footsteps of other financial institutions such as Paypal and MailChimp who also withdrew their services, after high-profile activists targeted their organisations on Twitter.
Netflix has gone too far.
Please help us fight against Premier Doug Ford's act of political suppression in ousting MPP Belinda Karahalios from the Progrssive Conservative caucus for voting against the authoritarian Bill 195. It is essential that politicians are free to represent their constituents, not the whims of their party's leader.
On July 21st, Ontario Member of Provincial Belinda Karahalios was kicked out of the Progressive Conservative Party caucus by Premier Doug Ford after voting against her party on Bill 195.
Notorious radical leftist billionaire George Soros and huge national and multi-national corporations are attempting to compel Mark Zuckerberg to silence CitizenGO's pro-Life, pro-Family, pro-Liberty speech on Facebook.
If they succeed, CitizenGO's outreach on Facebook will be crippled or removed entirely.
Facebook is one of the world's largest and most popular social media gathering places.
In his report, the Special Rapporteur on Freedom of Religion or Belief, Mr. Ahmed Shaheed, has chosen to pursue a controversial agenda that includes abortion and LGBT+ rights that are out of step with the convictions of law-abiding and non-violent religions and religious adherents. In doing so, he accuses religious institutions and religious adherents of discrimination.


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The Datalystica team
We are an extremely motivated and dynamic team. The company is in expansion and currently composed of two scientists with several years of experience in statistics and programming. Our main field of expertise is the analysis and source apportionment of environmental aerosol data.
Dr. Francesco Canonaco
CEO, member of the board & Software engineer


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Covid-19 Analysis on Silk Market: Demand, Size, Share, Trends, Key Player profile and Regional Outlook by 2025
04/set/2020 15:16:06 Tejas Amale Contatta l'autore
According to the MRFR analysis, the Global Silk Market is projected to register a CAGR of 7.91% during the forecast period to reach USD 22.78 billion by 2025.
Silk is a natural fiber obtained from different species of arthropods such as silkworms, mites, and spiders. Silk owing to its characteristics such as highly lustrous, soft and glossy appearance is extensively used in the textile industry. For instance, in India, MUGA silk on the account of its high exquisite appearance is used to make sarees and dresses. Thus, the increasing use of silk fiber in the textile industry is expected to drive the global market growth. However, the high cost of silk is likely to pose a limitation to the growth of the silk market during the forecast period.
Get a Free Sample Now@ https://www.marketresearchfuture.com/sample_request/8464
Pricing and Regulations
In 2018, the product was priced around USD 42,000–51,000 per ton across the globe.
Some of the methods for textile analysis are:
- American Society for Testing and Materials: ASTM D2256 – 02- Standard Test Method for Tensile Properties of Yarns by the Single-Strand Method
- American Society for Testing and Materials: ASTM D276 – 12 Standard Test Methods for Identification of Fibers in Textiles
- The International Organization for Standardization: ISO 21046:2018(en)- Test method for determining the size of silk yarns
Global Trade
The global silk import and export in 2018 was valued at USD 440,051 thousand and USD 400,813 thousand, respectively.
By Type
- Mulberry Silk: This is the most common silk among all the types and constitutes 89% of the total silk supply in the world. The segment accounted for the largest market share in 2018 and is expected to be the fastest-growing segment during the forecast period. Mulberry silk is the highest quality of silk available and is known for its high lustrous and elegant appearance. Due to the aforementioned properties, it finds a foray of applications in the textile industry to produce expensive garments and other textile products such as cushions, sofa covers, and drapes.
- Non-Mulberry Silk: Different types of silk are obtained depending upon the type of silkworm from which they have been obtained. Some of the known non-mulberry silk varieties of commercial importance are:
- Eri Silk: The eri silk is widely used in preparing winter shawls, traditional dresses, and blankets.
- Tasar Silk: Tasar silk is obtained from wild silkworms and is the second most-produced silk after mulberry silk. This silk type is mainly extracted from wild forest cocoon from India and is used as a base material for furnishing fabrics and printed apparel.
- Muga Silk: This type of silk is known for its extreme durability and natural golden color. Some of the garments made from muga silk are chaddar, chapkan, and mekhela.
- Spider Silk: These are protein fibers used by spiders to make the webs. Spider silk is widely used in biomedical applications on the account of its unique combination of high strength and rupture elongation properties.
- Others: This segment includes Anaphe silk, Fagara silk, Coan silk, and Mussel silk.
By End-Use Industry
- Textile: The largest segment in 2018 owing to the high demand for silk fabric to produce various apparel and other textile fabrics such as organza, chiffon, and pongee. Additionally, in order to diversify the applications of the product, silk is often blended with lyocell and polyester. This is thus augmenting the demand for silk in the textile industry. The segment is expected to showcase robust growth in the coming years owing to increasing usage of the product in the expanding textile industry across developing economies in the world. In addition, the increasing demand for blended silk fabrics is further propelling the demand for silk.
- Healthcare: Silk on the account of high biocompatibility and unique mechanical properties finds numerous applications in tissue engineering, drug delivery, dental sealants, and surgical implants. For instance, spider silk is widely used to coat the outer surface of the implant material to improve performance characteristics. However, the applications of silk in the healthcare sector are still in its incipient stage, thus offers lucrative opportunities for the key players operating in the silk market.
- Personal Care & Cosmetics: The growth of the segment is attributed to the increasing demand for silk protein on the account of skin elasticity, antiwrinkle, and antiaging properties in skin cosmetics.
By Region
- Asia-Pacific: It accounted for the largest market share in 2018 and is projected to be the fastest-growing regional market owing to the expanding textile industry. China, followed by India and South-East Asian countries, is the leading country on the account of the presence of major key players and rising disposable income among the consumers. Additionally, the increasing textile exports from the region is further driving the regional market growth.
- North America: The increasing demand for silk polymers in the medical industry to manufacture medical devices such as sutures, implants, and dental sealants is expected to fuel the growth of the regional market.
- Europe: The European market is expected to witness significant growth during the forecast period owing to the increasing demand for silk proteins, sericin, and fibroin, to produce skin, hair and nail cosmetics.
- Latin America: The regional market is witnessing sluggish growth; however, the growing textile industry is expected to fuel the demand for silk during the review period.
- Middle East & Africa: The increasing product usage in expanding textile and cosmetics industries is the major factor contributing to the regional market growth. Saudi Arabia, Turkey, and UAE are the key countries in the region contributing to the regional market growth.
Browse Full Report Details @ https://www.marketresearchfuture.com/reports/silk-market-8464
NOTE: Our team of researchers are studying Covid19 and its impact on various industry verticals and wherever required we will be considering covid19 footprints for a better analysis of markets and industries. Cordially get in touch for more details.
COVID-19 Study in Detail:
Impact of COVID-19 on Iso-Propyl Alcohol Market
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Are you worried that your employee may physically lose his laptop or it can be stolen on the next business trip? The Full Disk Encryption solution ensures your peace of mind. Full disk encryption automatically translates hard disk data into a form that can not be read by another. Without the correct authentication key, even if the hard disk is downloaded and placed on another machine, the data is left inaccessible. Ensure security for all information, including user data, operating system files, temporary and deleted files.
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The solution fully complies with the requirements of the new GDPR regulation for the protection and encryption of personal data.


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Design Independent Project
Project Description
Students proposed a self-directed project that utilized mediums, skills, and concepts learned over the span of this course in order to come up with a fully fleshed out proposal for a body of work. Students researched ideas and concepts, proposed a project based around a concept or subject matter, had to get approval for their project and a dedicated period of time in order to finish their work. Each student also had to create an Artist Statement where they formally analyzed their work. The course culminated with group critique where each student presenting their project including their Artist Statement, process and intent, and final curated work.
Project Steps
The class begins with a screening of the BBC documentary about art called "Why Beauty Matters," and a discussion surrounding the concept of art. The project begins with Step 1 – The Project Proposal. Students are guided through research and brainstorming for ideas about their projects. Students then had to write a project proposal that contained the following information:
What medium?
What is the concept?
How does this tie in with skills or concepts we have learned this year?
A short description of what proposed project.
Students then submitted their proposal and met with me for final approval.
Students then move to Step 2 – Documenting Progress. Students / Student Groups join the class blog where they post weekly updates of their work and respond to others work. They spend these subsequent class periods creating their projects. Finally they move on to Step 3 – Artist Statement & Project Presentation. Each student is given designated class time to craft theirArtist Statement and a presentation template to use as the base for their presentation.
Class Critique
Students are expected to present their project to the class for critique and review. The students work is also displayed for the school with a gallery showing.
Related Standards
ISTE: Creativity and Innovation
ISTE: Communication and Collaboration
ISTE: Critical Thinking, Problem Solving, & Decision Making


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Shop Announcement:
I am happy to receive custom orders, please just email me with your specifications and we can open a dialogue to ensure what you would like created for you is exactly what you want!
I do not work from patterns, everything I create is from my own imagination and totally unique.
Designer yarns are my favourite, I love creating unique items with that special designer touch!
Unfortunately due to not being signed up to the new recycling laws in Germany I can no longer ship there any orders received for delivery to Germany will be refunded in full.
Thank you for supporting British Crafters and buying handmade!
Burgundy Rose Shawl Pin or crocheted Corsage, with Kilt Pin.
Burgundy Rose is a crocheted Shawl pin or corsage, if you prefer, which has been crocheted with two combined yarns in the Rose, and separated to create differing and contrasting leaves that compliment the Rose perfectly!
This shawl pin or corsage has been hand crocheted and is a very textural 3D brooch, fashioned in the form of a rose in full bloom, complete with two leaves, one a plain burgundy and one burgundy blended marbled yarn.
The rose has been crocheted with the two seperate plain burgundy and marbled burgundy combined, in a Tripple shell like crochet stitch, the leaves in simple double crochet.
This shawl pin or Corsage would be ideal as a gift of love. Would look lovely holding together your favourite shawl or wrap, the kilt pin attachment, making it suitable for securing larger items of clothing, or as a decorative corsage.
The rose has been secured onto a silvertone kilt pin, to help secure the shawl pin to your clothing and help it remain where you pinned it.
I do not work from patterns, everything I create is from my own imagination and totally unique.
The yarn for this pretty item is 100% Acrylic, so washable with care up to 40'C. I would suggest sponging or hand washing, shaping whilst damp and drying flat to retain its shape.
Approximate measurements: 10cmes in width, including the leaves. The head of the rose alone measures approx 7cms in diameter. The depth of the brooch, including the pin mechamism is approx 4cms.
Colour Disclaimer. Actual colours may vary. This is due to the fact that every computer monitor has a different capability to display colours and that everyone sees these colours differently. Therefore I cannot guarantee that the colour you see accurately portrays the true colour of the product.
Shipping & delivery
This item will be posted to you by NOfkantsCurios Handmade Curios by Natalie Ofkants within 3 days of receiving payment.
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Returns Policy
You have 14 days, from receipt, to notify the seller if you wish to cancel your order or exchange an item.
Unless faulty, the following types of items are non-refundable: items that are personalised, bespoke or made-to-order to your specific requirements; items which deteriorate quickly (e.g. food), personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken.


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Huskisson Bed and Breakfast – Jervis Bay
Shoalhaven tourism NSW Photographer
Mt Hay Luxury Retreat Berry NSW
Mt Hay Luxury Retreat for Shoalhaven Tourism
Kioloa Shoalhaven NSW
It is worth following the sign for Kioloa as you head south towards the better known Pretty and Merry beaches. The protected beach is the perfect spot for playing and fishing.
Fairgrounds Music Festival Berry NSW for Shoalhaven Tourism
Fairgrounds Music Festival Berry NSW for Shoalhaven Tourism
Tyler Wright , world title pro surfer
Tyler Wright for Surfing Shoalhaven
Top Fireplaces in the Shoalhaven for Shoalhaven Tourism
Huskisson Jervis Bay NSW for Shoalhaven Tourism
Milton for Shoalhaven Tourism
Milton seems to have it all. This pretty historical town is a creative hub with a foodie heart!
Dolphin Sands Bed and Breakfast – Jervis Bay
Dolphin Sands Bed and Breakfast – Jervis Bay
Greenwell Point Shoalhaven NSW
It takes more than a day to soak up this salty paradise!
Milk Haus at Woodstock NSW
Milk Haus is an essential south coast foodie stop. Built in the old cheese factory at Woodstock just outside of Milton, Milk Haus serves wholefoods grown in their own kitchen garden.
Nowra, NSW for Shoalhaven Tourism
Nowra, NSW for Shoalhaven Tourism.
Kangaroo Valley NSW, for Shoalhaven Tourism
A little taste of a beautiful valley, Kangaroo Valley is a country escape day dream come true!
Shoalhaven Heads, NSW for Shoalhaven Tourism
Bundanon Trust – NSW- Siteworks – 2018
Shoalhaven Beekeepers Association for South Coast Style
Shoalhaven Beekeepers Association for South Coast Style
Cupitts Winery NSW for South Coast Style
Berry Sourdough Cafe
Katie Rivers is a freelance photographer with more than 25 years' experience in the industry. Having studied every aspect of photography, from dark room to digital, she applies her knowledge to everything from editorial photography work for major publications to beautiful, contemporary wedding photography. Katie Rivers Photography is based in Berry, NSW - Katie covers assignments from the south coast of NSW to Sydney.
Katie Rivers Photography is well known locally in Berry, South Coast NSW and Sydney for her candid approach to photography. Her wedding photography is out of this world. Katie's eye for detail and ability to capture the magical moments of your wedding day will make your wedding pictures unique. Take a look at the wedding pictures to find out more about Katie's wedding photography.


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acknowledge that writing is hard. write it down. then write about how your'e going to make writing happen. how will you find the balance in yourself to combine willpower with relaxation, stubborness with joy? write about how you've struck this balance in the past, with writing, a sport a musical instrument -- anything you've done.
writing is hard.
sometimes it's harder than others, especially since i write with my emotions and sometimes my emotions aren't very conducive of prolific writing. fortunately my current emotional state is very conducive to writing, which means that i am. at the moment i make myself sit down at least once a week and put down a thousand words or more relating to what i'm feeling and what i'm thinking. so far, that's all i do to find the balance.


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Astrocytomas are heterogeneous intracranial glial neoplasms ranging from the highly aggressive malignant glioblastoma multiforme (GBM) to the indolent, low-grade pilocytic astrocytoma. We have investigated whether DNA microarrays can identify gene expression differences between high-grade and low-grade glial tumors. We compared the transcriptional profile of 45 astrocytic tumors including 21 GBMs and 19 pilocytic astrocytomas using oligonucleotide-based microarrays. Of the ∼6800 genes that were analyzed, a set of 360 genes provided a molecular signature that distinguished between GBMs and pilocytic astrocytomas. Many transcripts that were increased in GBM were not previously associated with gliomas and were found to encode proteins with properties that suggest their involvement in cell proliferation or cell migration. Microarray-based data for a subset of genes was validated using real-time quantitative reverse transcription-PCR. Immunohistochemical analysis also localized the protein products of specific genes of interest to the neoplastic cells of high-grade astrocytomas. Our study has identified a large number of novel genes with distinct expression patterns in high-grade and low-grade gliomas.
GBM, 3 which is synonymous with grade IV astrocytoma and which is the most common type of brain tumor, is considered to be one of the most malignant human neoplasms (1) . GBMs arise either through an anaplastic progression from a lower-grade astrocytoma or de novo, without evidence of an antecedent lesion. Pilocytic (grade I) astrocytomas have a more favorable prognosis than diffuse astrocytomas and are characterized by a more circumscribed growth pattern with a limited infiltrative behavior and infrequent anaplastic progression. The extensive heterogeneity of astrocytic tumors has made their pathological classification rather difficult. Although several genes have been identified to be associated with tumorigenesis and anaplastic progression of gliomas (2 , 3) , their contribution to the molecular classification of astrocytic tumors has been limited.
Molecular expression profiles using oligonucleotide or cDNA-based microarrays have been used to derive a molecular-based classification of several cancer types including B-cell lymphomas, malignant melanomas, and breast cancer (4, 5, 6) . To date, few studies have reported the expression profile of astrocytic tumors. In studies of the expression profile of 588 known genes in a set gliomas, IGFBP2 gene was found to be overexpressed in GBMs (7 , 8) . More recently, a study analyzing the expression of 1176 cancer-associated genes in 11 grade II astrocytomas uncovered six genes, including TIMP3, EGFR, and GDNPF, that were expressed in 64–100% of grade II tumors and were not expressed in three non-tumor tissue samples derived from three different brain regions (9) . It was also reported that seven genes, including PDGFR-α, PTN, LRP, and SPARC, were up-regulated by at least 2-fold in 20–60% of the grade II tumors compared with the non-tumor brain tissue samples.
In this study, we used oligonucleotide microarrays to compare the expression pattern of ∼6800 genes between grade IV and grade I astrocytic tumors. We have identified a group of 360 genes that distinguish grade IV from grade I astrocytomas and have found clusters of tumors that conform to their clinicopathological classification as well as outlier tumors that clustered with tumors of a different grade.
Tissue Samples and Cultured Cells.
Forty-five primary gliomas and 6 normal brain samples (neocortex of the temporal lobe from 6 different adult brains) were obtained, after informed consent, from patients undergoing tumor resection or other brain surgery at the University of Michigan Medical Center. Portions of the tumors were fixed in 10% formaldehyde and embedded in paraffin for sectioning, and the remainder of the tissue samples were snap-frozen in liquid nitrogen and stored at −80°C for RNA extraction.
Microarray Analysis.
Total RNA was isolated using Trizol reagent (Life Technologies, Inc.) from 51 tissue samples, followed by clean-up on a RNeasy spin column (Qiagen), and 15 μg was used to generate cRNA probes. A mixture of control cRNAs (made from the bacterial genes BioB, BioC, and BioD and the phage gene cre, purchased from Affymetrix) were used for quality control. Aliquots of each sample (10 μg of fragmented cRNA in 200 μl of hybridization cocktail) were hybridized to HuGeneFL arrays at 45°C for 16 h in a rotisserie oven set at 60 rpm. The arrays were then washed with nonstringent wash buffer (6× SSPE) at 25°C, followed by stringent wash buffer [100 mm MES (pH 6.7), 0.1 m NaCl, and 0.01% Tween 20] at 50°C, stained with streptavidin phycoerythrin (Molecular Probes), washed again with 6× SSPE, stained with biotinylated anti-streptavidin IgG, followed by a second staining with streptavidin phycoerythrin and a third wash with 6× SSPE.
The chips were scanned using the GeneArray scanner (Affymetrix) at 3-μm resolution. Each Hu6800 chip consisted of 287,296 24-×-24-um features that were 25 base-long single-stranded DNA. For each feature, the Affymetrix (GeneChip 4.0) software ignored a 1-pixel border and the 75th percentile of the remaining pixels stored in file (CEL files). For each transcript or probe-set, there were typically 20 pairs of features (probe-pairs) on the arrays, 20 of which were designed to be complementary to a specific sequence (PM features), and the other 20 being identical to the PM features except for a substitution of a base centrally located (MM features). We have developed software to read these files for further processing of the data. For standardization, a reference array was used that was selected based on having a relatively average range of intensities. Probe-pairs for which either the PM or MM feature were saturated (pure white = large pixel values) in the image of the reference array, or for which PM-MM was ≤1000 were excluded from further consideration. The latter cases usually gave highly negative PM-MM values on all chips. Saturated features (with measures >98% of the saturated value) on other chips were imputed separately for PM or MM values. For a saturated PM value, the ratios of nonsaturating PM values for the chip divided by the standard were averaged for a probe-set by taking the antilogarithm of the mean of the log ratios. This factor was multiplied by the PM values of the standard to impute values for the chip under consideration. A one-sided Wilcoxon signed-rank test was performed on the PM-MM differences to determine whether the transcript represented by the probe-set was present or absent. The average intensity for each probe-set was computed as the mean of the PM-MM differences, after trimming away the 25% highest and lowest differences.
To normalize the data, we first removed a set of 64 probe-sets that were used for quality control and one additional probe-set that consistently yielded high negative values. The distribution of the remaining average intensities for each chip was normalized to the median value of all of the chips by setting 99 evenly spaced quantiles to have the same values as the median, and using linear interpolation between these points for the remaining probe-sets (software generated and kindly supplied by Dr. Kerby Shedden, University of Michigan). To compute fold changes between the different tissue-type groups, we first replaced all values less than 100 with 100 to reduce spuriously large (or negative)-fold change indices. We then used the ratio of the mean normalized intensity as the fold difference between any two groups. To determine the significant differences between the mean normalized intensities, we first added 100 to each normalized intensity and replaced all of the remaining negative values with 0. We then added 10 to each of the new values and performed a logarithmic (log10) transformation of the data to stabilize the variance and to minimize the effect of negative normalized intensities. We then fit one-way ANOVA models with separate means for each of the four groups. We performed six F tests testing each of the hypotheses that the means of the trimmed average intensities in two of the four groups were identical. Complete hierarchical clustering of the genes and individual samples was done using the Cluster program 4 to arrive at a Pearson correlation coefficient (10) . Normalized intensities were further normalized using the Cluster program resulting in a mean intensity value of 0 and SD of 1.
For the 20 tumor samples (10 grade I and 10 grade IV), we relied on the TaqMan assay (Perkin-Elmer model 7700; Foster City, CA) to quantitate the amount of FOXG1B, FOXM1, SDC1, FLN1, and ZYX mRNA. To decrease background from genomic DNA, we designed the reverse primer to be complementary to the polyadenylic tail including 3–10 nucleotides 3′ to the polyT region described previously (11 , 12) . The forward and reverse primers and fluorescently tagged probe used for the FOXG1B gene in the assay were 5′-TGTTGTCTTAAAATTTCTTGATTGTGATAC, 5′-TTTTTTTTTTTTTTTTTTTTTTTTTATATGAA, and 5′-6FAM-TGGTCATATGCCCGTGTTTGTCACTTACA-TAMRA, respectively. The forward and reverse primers and fluorescently tagged probe used for the FOXM1 gene in the assay were 5′-TGCCCCTCAGCTTTGCA, 5′-TTTTTTTTTTTTTTTTTGTCCACCTT, and 5′-6FAM-CTGGCTCACACCCATGCGGTCA-TAMRA, respectively. The forward and reverse primers and fluorescently tagged probe used for the SDC1 gene in the assay were 5′-CTGGGCTGGAATCAGGAATATT, 5′-TTTTTTTTTTTTTTTTTTTTTTTAGAAGAAATA, and 5′-6FAM-TTGCCAAAAGCAAAAGACTATCACTCTTTGGA-TAMRA, respectively. The forward and reverse primers and fluorescently tagged probe used for the FLN1 gene in the assay were 5′-GGACCGCGAGAGCATCAA, 5′-GGAGATGGAGTAGTGCAGGATCA, and 5′-6FAM-CTGGTGTCCATCGACAGCAAGGCC-TAMRA, respectively. The forward and reverse primers and fluorescently tagged probe used for the ZYX gene in the assay were 5′-GGGAGACCCTCCAGGACATT, 5′-TTTTTTTTTTTTTTTTTTTTTCTGGAAA, and 5′-6FAM-CCCATGCTGCCAAGTTGTAGCTATAGCTACAA-TAMRA, respectively. The forward and reverse primers and fluorescently tagged probe used for the β-actin (ACTB) gene were 5′-AACTTGAGATGTATGAAGGCTTTTGG, 5′-TTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAG, and 5′-6FAM-CAACTGGTCTCAAGTCAGTGTACAGGTAAGCCCT-TAMRA, respectively. To measure the relative abundance of two genes in a given RNA sample, the amplification value derived using the first sequence (FOXG1B, FOXM1, SDC1, FLN1 or ZYX) was divided by the amplification value using the second sequence (ACTB). Derivation of this fraction is independent of RNA sample concentration, eliminating the requirement to measure RNA concentration accurately. To compare the measured expression data derived from the Taqman assay and the microarray analysis, we scaled each data set by dividing by the mean amplification ratios and the intensity values for a given gene, respectively.
Paraffin-embedded serial sections of either grade IV or grade I tumors analyzed by microarray analysis and TaqMan, were stained with H&E, with a mouse monoclonal antibody against the human filamin protein (1:25 dilution of anti-ABP200; Transduction Laboratories, Lexington, KY), or with a goat polyclonal antibody against the human syndecan-1 protein (1:100 dilution; Santa Cruz Biotechnology, Santa Cruz, CA). Sections stained for filamin were pretreated with a 10 mm citrate buffer for 10 min to enhance antigen retrieval. Sections stained for syndecan-1 were blocked with 0.1% avidin for 10 min and then with 0.01% biotin for 10 min before the addition of the anti-syndecan-1 antibody. We used a Ventana ES automated immunostainer (Ventana Medical Systems, Tucson, AZ.) and LSAB+ peroxidase-based visualization (DAKO, Carpinteria, CA).
We analyzed the expression of ∼6800 genes using Affymetrix Hu6800 GeneChip microarrays for 45 astrocytic tumors, consisting of 19 grade I, 5 grade II, and 21 grade IV tumors, and for 6 normal tissue samples obtained from the neocortex of the temporal lobe from 6 patients who underwent surgery for epilepsy. The design of these oligonucleotide-arrays has been previously described (13) . A one-sided Wilcoxon signed-rank test of the individual oligonucleotide features for each probe set was used to determine whether a transcript was either present or absent in a given sample. We determined that from the entire set of genes represented on the Hu6800 chip, ∼4648 genes had measurable intensity values in at least 2 of the 51 samples analyzed (P < 0.01). We compared the mean intensity values for each gene in one sample type to the mean intensity values obtained from other sample types to determine fold difference in the measured expression levels. Table 1 ⇓ summarizes the number of gene differences between the comparison groups. Of the 4648 genes, 360 genes differed in their expression between grade IV and grade I tumors by at least 1.5-fold in mean intensity (P < 0.01). Of the 360 genes, 167 had increased and 193 had decreased measured expression levels in grade IV tumors relative to grade I tumors. A total of 183 genes (including 47 of the 167 genes) were expressed at a higher level in grade IV relative to 5 grade II astrocytomas. In addition, 703 genes, including 86 of the set of 167 genes, were expressed at a higher level in grade IV tumors compared with normal brain tissue samples.
We performed hierarchical clustering of the set of 360 genes that differed in their expression between grade IV and grade I tumors, to determine the expression pattern of this set of genes in grade II tumors and normal brain (Fig. 1) ⇓ . Most genes that were overexpressed in grade IV relative to grade I were also overexpressed relative to grade II and normal brain. Likewise, most genes that were overexpressed in grade I relative to grade IV were overexpressed relative to grade II and normal brain. A subset of genes were reduced in their expression in grade IV relative to all other. Dendrograms based on the expression patterns of the 360 genes and of the entire set of 4648 genes are shown in Fig. 1, B and C ⇓ , respectively. On the basis of the set of 360 genes, samples derived from grade IV tumors (coded in red) clustered independently from samples derived from grade I (coded in blue). A similar distinction between the two sample types was observed based on the expression pattern of the entire gene set. In both dendrograms, two samples derived from tumors that were diagnosed as either grade IV or grade I clustered with samples derived from tumors of differing grades.
Overexpression of the EGFR, MDM2, CDK4, CD44, and IGFBP2 genes is well described in gliomas (7 , 14, 15, 16) . Fig. 1D ⇓ shows a representation of the measured expression level of EGFR, MDM2, CDK4, CD44, and IGFBP2 in each sample. The color of each cell represents the number of SDs above (red) or below (green) the mean of the log-transformed normalized intensity values obtained for that gene in all of the samples. Consistent with previous reports, we observed an increased expression of these genes predominantly in GBMs.
Tables 2 ⇓ and 3 ⇓ list a subset of the genes in the gene clusters shown in Fig. 1A ⇓ , including the ratio and P of the mean intensity values that distinguished grade IV astrocytoma from grade I pilocytic astrocytoma. A large subset of the 360 genes was functionally categorized, based on known or inferred biological function of their protein product. Many of the genes that were overexpressed in grade IV tumors encode proteins that are involved in cell proliferation or enhanced cell migration. These include DNA repair/replication/maintenance proteins, transcription and translation regulators, cell cycle-mediating proteins, ECMs or ECM-associated proteins, cytoskeleton and cytoskeletal organizing proteins, and cell adhesion molecules.
We chose five genes that have not been previously associated with GBM to measure their mRNA levels by real-time quantitative RT-PCR (TaqMan assay). Total RNA from 20 tumor samples (10 of the original 19 grade I and 10 of the original 21 grade IV tumors) were analyzed for the expression of ZYX, SDC1, FLN1, FOXM1, and FOXGB1, relative to the level of β-actin (ACTB) mRNA in each sample. ACTB was chosen for a reference because its mRNA levels, measured by microarray analysis, were comparable between grade I and grade IV tumors (1.1-fold difference; P = 0.132). Consistent with the microarray data, we measured at least a 2-fold higher level of mRNA for all five of the genes in grade IV relative to grade I tumors, using the Taqman assay (Fig. 2A) ⇓ . Remarkably, the pattern of gene expression from sample to sample observed by microarrays paralleled the pattern observed using Taqman (Fig. 2B) ⇓ . The minimum and maximum correlation coefficients (r) between grade IV and grade I samples are 0.62 (FLN1) and 0.92 (FOXM1), respectively.
Antibodies for immunohistochemistry were readily available against the gene products of two of the five genes analyzed by the TaqMan assay. FLN1 encodes for filamin (also known as ABP-280), a Mr 280,000 homodimeric actin-binding protein that is involved in cell migration of a variety of cell types and in the invasiveness of melanocytes (17) . Filamin was abundantly expressed in the cytoplasm and processes of the neoplastic cells in GBMs and was particularly abundant in multinucleated and mononucleated giant cells (Fig. 3) ⇓ . We also observed a high level of syndecan-1, the gene product of SDC1, in the neoplastic cells of grade IV tumors. Syndecan-1 is a cell-surface, heparan-sulfate proteoglycan predominately expressed in epithelial cells (18) . It functions as a coreceptor for soluble (e.g., FGF2) and insoluble (e.g., ECM components) ligands, as a soluble paracrine effector, and as a mediator of cell-surface protein internalization (18) . No detectable staining for syndecan-1 was observed in grade I tumors.
Gliomas have an inherent property of heterogeneity and, thus, are problematic in terms of accurate diagnosis. Therefore, we have examined the global expression profile of gliomas to identify molecular characteristics that distinguish the most aggressive and malignant glioma (GBM) from tumors of a more indolent nature (grade I pilocytic astrocytoma). We observed a significant difference (P < 0.01 with at least a 1.5-fold difference) in the expression level of 360 genes between grade IV and grade I tumors. Many of the genes with increased expression in GBMs encode proteins that are involved in cell proliferation or that have been reported to affect cell migration in other tissues or cell types (Table 2) ⇓ . Some of the genes involved, first identified in yeast, are members of a highly conserved family of genes encoding minichromosome maintenance proteins that form a prereplicative complex that binds to the origin of replication sites (19) . These proteins have previously been correlated with cellular dysplasia and tumor malignancy of several types of cancers but, to date, have not been associated with gliomas (20) .
Some members of the winged-helix family of transcription family were overexpressed in GBMs. FOXG1B and FOXM1 encode for the proteins fork head box G1B and fork head box M1, respectively. FoxG1B, also known as brain factor-1, was originally isolated from a fibrosarcoma-inducing virus and is the putative oncogene of the avian sarcoma virus 31 (21) . It has restricted expression in neurons of the developing brain and interacts with DNA-binding proteins that interfere with the transcriptional activation by Smad proteins. This interaction inactivates the transforming growth factor β/activin-regulated cell cycle arrest and growth inhibition (22 , 23) . FoxM1 exhibits a wider expression pattern in the embryo than does FoxG1B and has been implicated in the induction of hyperproliferation (24) . We also observed increased expression in GBMs of genes that inhibit apoptosis. For example, we detected increased survivin expression in GBMs relative to normal brain or to grade I or grade II tumors. Survivin has been found to be overexpressed in other cancers. It maintains the proliferative state of cells by counteracting a default induction of apoptosis in G2-M phase and favoring aberrant progression of transformed cells through mitosis (25) .
Hyperproliferation is a unifying feature of high-grade gliomas and is accompanied by a high degree of invasion into the surrounding brain parenchyma by neoplastic cells. We observed increased expression in GBMs of genes encoding for proteins likely involved in cell migration. Apart from cell adhesion molecules, we found several cytoskeleton and cytoskeletal-associated proteins that were highly expressed in grade IV tumors. Proteins that promote both cross-linking and severing of actin networks are necessary for efficient cell locomotion (17) . Actin-binding protein-280 (filamin) and members of the gelsolin family of proteins (e.g., capping protein and villin) function in these capacities, respectively. We also found an increase in the level of ZYX mRNA in GBM relative to low-grade tumors. ZYX encodes for the protein zyxin, which is also involved in the assembly of actin filaments during cell migration (26) . More recently, it has been shown that zyxin shuttles between the nucleus and sites of cell adhesion. In the nucleus, it binds to and inactivates the tumor suppressor protein h-warts/LATS1 (27) . Whether zyxin functions in GBMs to promote cell migration, inhibit h-warts/LATS1, or both, is unknown.
Compared with GBMs, genes that encode proteins involved in cell motility were expressed at a reduced level in grade I tumors. Moreover, genes involved in suppressing migration were expressed at higher levels in grade I relative to grade IV tumors (e.g., SIAT8A: ratio, 1.7; P < 0.001; TIMP3: ratio, 1.6; P < 0.001; and TIMP4: ratio, 2.3; P <0.001). Polysialylation of NCAM is achieved by α2,8-polysialyltransferases (encoded by SIAT8A), which inhibit NCAM-mediated cell adhesion and migration (28 , 29) . Members of the family of TIMPs are also known to inhibit cell migration by inhibiting proteolysis of ECM and ECM receptors on the surface of the cell. TIMP4 has been shown to inhibit the invasive potential of human breast cancer cells (30) .
Microarray analysis and Taqman assay yielded concordant results for differences in gene expression between grade IV and grade I tumors for the genes tested, which consisted of ZYX, SDC1, FLN1, FOXG1B, and FOXM1. In general, changes in transcript abundance were underestimated by microarray analysis (Table 1) ⇓ . However, for each gene across 20 samples, we obtained a high correlation between the two assays. For two of the five genes that we investigated by immunochemistry, we further demonstrated that their protein products were overexpressed in tumor cells of GBMs relative to pilocytic astrocytomas. These two proteins were chosen from the five based on the availability of commercial antibodies for immunohistochemical assays. Their abundant expression in the tumor cells of GBMs suggests that they may play a role in the infiltration of these cells into the surrounding normal brain.
One grade I tumor (no. 265) clustered with grade IV tumors based on the set of genes that displayed a significant difference in their expression pattern between the two groups. This tumor exhibited increased FLN1 mRNA, as measured by both microarray analysis and TaqMan, as well as increased FLN1 protein, as measured by immunohistochemistry, compared with other pilocytic astrocytomas. This tumor also displayed several cellular features associated with high-grade tumors, including hypercellularity, an increase in nuclear pleomorphism and a high nuclear:cytoplasm ratio. The existence of a "diffuse" variant and subsequent malignant transformation of pilocytic astrocytomas has been proposed as an explanation for the aberrant grouping of this particular tumor (31) . However, more studies are needed to determine the pathological significance of low-grade tumors that cluster with GBMs.
Our study has uncovered a large number of genes with distinctive expression patterns in grade IV and grade I tumors. A substantial number of these genes have not been previously associated with gliomas. The study provides a molecular profile for astrocytic neoplasms which may be relevant to diagnosis and therapy.
We thank Dr. Kerby Shedden in the Department of Statistics at the University of Michigan for his thoughtful discussions and the normalization software that were invaluable for the analysis of the microarray data.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
↵1 Supported in part by NIH Grant CA84953 from the National Cancer Institute.
↵2 To whom requests for reprints should be addressed, at Department of Pediatrics, University of Michigan Medical Center, 1150 West Medical Center Drive, A520 Medical Science Research Building I, Ann Arbor, MI 48109-0656. Phone: (734) 763-9311; Fax: (734) 647-8148; E-mail: shanash{at}umich.edu
↵3 The abbreviations used are: GBM, glioblastoma multiforme; IGFBP2, insulin-like growth factor binding protein 2; PM, perfect match; MM, mismatch; ECM, extracellular matrix; RT-PCR, reverse transcription-PCR; TIMP, tissue inhibitor of metalloproteinase(s).
↵4 Internet address: http://rana.stanford.edu/software.
- Received March 19, 2001.
- Accepted July 17, 2001.
- ©2001 American Association for Cancer Research.


text:
- abstract form
- Математика: абстрактная форма
Универсальный англо-русский словарь. Академик.ру. 2011.
Смотреть что такое "abstract form" в других словарях:
abstract (form) — a type of film that rejects traditional narrative in favor of using poetic form (color, motion, sound, irrational images, etc.) to convey its meaning or feeling; aka non linear; see also avant garde Examples: Rene Clair s Entr acte (1924),… … Glossary of cinematic terms
Abstract management — is the process of accepting and preparing abstracts for presentation at an academic conference. The process consists of either invited or proffered submissions of the abstract or summary of work. The abstract typically states the hypothesis,… … Wikipedia
abstract expressionism — abstract expressionist. (sometimes caps.) a movement in experimental, nonrepresentational painting originating in the U.S. in the 1940s, with sources in earlier movements, and embracing many individual styles marked in common by freedom of… … Universalium
Abstract nonsense — Abstract nonsense, or general abstract nonsense, alternatively general nonsense, is a popular term used by mathematicians to describe certain kinds of arguments and concepts in category theory or applications.HistoryThe term predates the… … Wikipedia
Abstract impressionism — is a type of abstract painting (not to be confused with Abstract Expressionism, a similar but different movement) where small brushstrokes build and structure large paintings. Small brushstrokes exhibit control of large areas, expressing the… … Wikipedia
Abstract index notation — is a mathematical notation for tensors and spinors that uses indices to indicate their types, rather than their components in a particular basis. The indices are mere placeholders, not related to any fixed basis, and in particular are non… … Wikipedia
Abstract analytic number theory — is a branch of mathematics which takes the ideas and techniques of classical analytic number theory and applies them to a variety of different mathematical fields. The classical prime number theorem serves as a prototypical example, and the… … Wikipedia
abstract — ab‧stract [ˈæbstrækt] noun [countable] a short written statement that contains the most important details of a longer piece of writing such as a newspaper article, a report, or a speech: • an abstract of the Chairman s speech to the shareholders… … Financial and business terms
abstract — for adj. [, ab strakt′, ab′strakt΄; ] for n.1 & vt.4 [, ab′strakt΄; ] for n.2 [, ab′strakt΄, ab strakt′; ] for vt.1, 2, & 3 [, ab strakt′] adj. [< L abstractus, pp. of abstrahere, to draw from, separate < ab(s) , from + trahere, to DRAW] 1 … English World dictionary
Abstract film — is a subgenre of experimental film. Its history often overlaps with the concerns and history of visual music. Some of the earliest abstract motion pictures known to survive are those produced by a group of German artists working in the early… … Wikipedia
Form — • The original meaning of the term form, both in Greek and Latin, was and is that in common use • eidos, being translated, that which is seen, shape, etc., with secondary meanings derived from this, as form, sort, particular, kind, nature… … Catholic encyclopedia
- The World Ornament Sourcebook, . This book has above all a practical purpose. It is an album of illustrations rather than a treatise, and gives examples rather than precepts. In it we wished to avoid the underwater hazards… Подробнее Купить за 2309 руб
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- Vasily Kandinsky, . Vasily Kandinsky was one of the first painters of abstract art and a founding member of the Blue Rider movement. Although he trained as a lawyer, Kandinsky abandoned this career path to… Подробнее Купить за 1291 грн (только Украина)


text: On 11/06/2010 10:28 AM, Ralf Treinen wrote: > Mehdi Dogguy wrote: > >> Nowadays, It seems that planet.debian.org became an important news >> media and has a fairly large number of readers. I think that a >> large number of mails sent to d-d-a (or debian-announce) may take >> advantage of this media to gain more visibility (e.g. various RFH >> sent to d-d-a by various teams). > > I don't like it. If someone needs to know the messages of d-d-a then > s/he should subscribe to that list; serving people who might have > only a passing interest isn't sufficient reason to burden planet > with it. I find this comment quite inappropriate. Do you think that news about Debian are burden on one of the most important news media Debian has? I already filter Planet's content by looking at the titles (e.g. I don't read my blog posts :) or when the subject doesn't seem interesting for me). I'm quite sure you do pretty the same too. Debian Planet is also a way to communicate with our users, upstreams and contributors. Thus, its quite natural to publish news about the development happening in Debian on Planet and I won't consider that a burden, even if it's published on a dedicated mailing list. Besides, the traffic on d-d-a (and even with d-announce accumulated) is very very low… compared to the number of posts published on Planet each month. So, you're against basically a few messages by month? > I always read my mail (possibly with a delay), but I look at planet > only when I have some spare time, and then I'd prefer to not see > there again the stuff that I have already read via mail. > In any case, there are several ways to filter rss feeds. You might have a look to reduce the "burden". A quick google search brought me to [1] and [2]. [1] http://www.feedrinse.com/ [2] http://liferea.sourceforge.net/scripting.htm Regards, -- Mehdi Dogguy مهدي الدڤي http://dogguy.org/


text:
- Hair Transplant
- Obesity / Diabetes
- Dental Clinic
- Beauty Operation
Obesity operations
Steps hair growth and healing after a hair transplant as well as the most important instructions and guidelines of. What we will talk about it applies to cases of hair transplants for men and women and the transplantation of the beard .
It is important to remember that each person will have experience of different conditions in the ten transplantation process, first the number of follicles excerpted and planted from the hair can vary greatly from one person to another depending on the needs of its own, and a second body each person interacts with things in different ways.
There are no principles or common standards among all, not even the exact date for the appearance of the final results, but there are indications of which to be aware that you are okay and you are moving towards the desired result.
Our doctors based on their opinion of their experience and the number of operations they conducted and monitor the development of each case
Before you performed the hair transplant Our doctors will tell you about the expected outcome of the process, according to the health condition and quality of the hair in the donor area density, so but can not be any doctor that sets you a precise date 100% gives you the best expected result.
Immediately after the hair implant process will be able to see the outline of the new hair, however it will not necessarily be the final result, and this is determined by the extent of your commitment to the instructions of the doctor.
In theory, you can return to work the next day, but I always recommend that you take a few days rest to fully recover and give yourself enough space of time to complete the instructions after the hair transplant. Where the doctor will advise specific guidance including what is in them and what is special for your condition.
After a few days after the operation, you will notice a big difference in the appearance of hair, and swelling can appear in the forehead area or the front and you will feel some pain. But it is important to remember that this will not be the final result.
After three to four weeks
After several weeks at least transplanted hair will start with precipitation and this is quite a normal part of the healing does not need to worry about it. In very rare cases. During this period, we should pay attention if you notice any bleeding or blood spots they must contact your doctor to figure out the appropriate action, but in the vast majority of cases, it is completely normal and does not constitute any threat to the success of the operation.
The donor area have recovered fully
New hair starts to develop in the skin texture but will be noticeable, in this case, the dermis of the new bulbs have completely docked to the dermis of the scalp and ended caution stage.
It is known that most people grow their hair at a rate of 1 cm per month, so you will see the vanguard of the new hair has started to appear after 5-6 months, and every day in the mirror, you will find several hairs have emerged, the most interesting phase in the hair transplant journey. Of course, here you will not see the final results of the operation to 12 months later to have this period extended to eighteen months in some people at the latest.
The evolution of the case of hair transplant during the first two weeks after the operation
Smoking leads to carbon dioxide enter the blood 200 times on what is normal, and this affects the amount necessary for the growth of follicles transplanted oxygen. Therefore we recommend not smoking before the operation, and four days after the hair transplant operation four days, or ease of smoking as much as possible.


text: wanderingoz #1 Posted August 23, 2019 I am having some difficulty finding as much information as I would like about some of the Uniworld excursions. (Ultimate European Journey, Bucharest -> Amsterdam) Can I ask of anyone who has cruised the Danube or Rhine with Uniworld, whether they have information sessions on board before excursion selections are made? If so, are these usually the day or evening beforehand? Thanks for any help you can offer. 0 Share this post Link to post Share on other sites


text:
Results 1 to 1 of 1
#1 The Russian Collusion Trial Is On, And Mueller May Be The First Casualty05-12-2018, 05:36 PMLawyers for Russian company Concord Management and Consulting, LLC, formally entered a not guilty plea in federal court Monday in a case special counsel Robert Mueller probably never thought would happen.
Mueller, weathering significant criticism that his Russian collusion case was thin, unveiled a grandiose indictment Feb. 16 against 13 Russian nationals and three Russian companies. The 13 Russians in question were charged with waging information warfare in the United States, interfering with the 2016 presidential election, and conspiracy to defraud the United States.
Mueller generated headlines with the February indictment, safe in the knowledge the 13 Russians were beyond U.S. jurisdiction. Therefore, there would be no trial only sensational Russian collusion accusations.
Mueller may now have to try the case, and Concords lawyers have put the special counsel on notice. The Russian companys lawyers intend to invoke discovery to obtain U.S. intelligence about what they knew of Russian activitiesUnknown philosopher at a St. Patrick's Day celebration 1967
1 beer between 3 guys is better than no beers between no guys
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Okay, before you run off for that well made java, this is not simply another one of those content strategy blogs'. Well, yes, it is about content advertising strategy, however it looks at where you are going wrong.
Ask yourself something:
- Why are you creating the content you're creating?
- How are you calculating its effectiveness?
- How do you choose what kind of content to place out?
If you do not have a well-planned content marketing strategy, you won't be able to get the right content in the right format out to the right audience in the right time.
To summarise, you are simply creating content for the sake of it. Things to contemplate when making your content strategy. Granted, writing is a good way of getting your info across, but it is also time intensive to read and, let us face it, a little boring. Think about your audience and what it's they might like.
Mix it up a little with:
- infographics
- videos
- cartoons
- as well as music.
This type of content is very acceptable and will help widen your reach.
Talking of increasing reach, how do you assess the success of your strategy?
Lots of businesses look at web traffic as their primary metric. Content is there to entice readers, so really the best measurement is the number of additional traffic it brings. Traffic is great, however it does not mean you'll automatically sell more. If you plump for traffic amount as your prime metric all you are doing is measuring an action not effects.
Sales lead quality and amount Direct sales Merchandise knowledge.
These metrics give an immediate relationship to the potency of your content strategy and sales. Let us face all of it the traffic in the world is worthless if it does not convert into sales. Before you get back to work to thine own very own strategy. Ensure you're putting out a wide range of content formats and measuring its impact utilizing the goals above.


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Available later this month, the 2014 Chevrolet Volt will start at US$34,995 ($38,900), including an US$810 ($900) destination fee. The price can fall as low as US$27,495 ($30,600) with federal tax credits factored in, making it almost half the price of the Holden Volt sold in Australia, which starts at $59,990 before on-road costs.
The price cut follows similar reductions from the Volt's key rivals in the US. Nissan slashed US$6400 ($7100) from the base price of its all-electric Leaf in January, bringing it down to US$28,800 ($32,000), while last month Ford cut US$4000 ($4500) from its Focus Electric, which now costs from US$35,200 ($39,200).
Federal tax credits see prices fall to as low as US$21,300 ($23,700) for the Leaf and US$27,700 ($30,800) for the Focus.
Leaf sales have more than tripled in the US this year to 11,703 on the back of the price cut, helping it take a narrow lead over the Volt, which has increased just nine per cent this year to 11,643 units to the end of July.
Holden sold eight Volts in Australia in July, taking its total 2013 sales to 75 following the car's launch at the end of last year. Nissan has sold 89 Leaf EVs in Australia so far this year, including 50 since May when the company introduced a $39,990 driveaway pricing offer, cutting more than $10,000 from its usual $51,500 list price.
Chevrolet US sales and service vice president Don Johnson said the company was able to reduce the price of the Volt partially because it has "made great strides in reducing costs as we gain experience with electric vehicles and their components".
Despite this, Holden public relations senior manager Andrew Matthews said the local division had "no specific plans" to cut Volt prices for our market at this stage, but said the company continued to look at the positioning of all its vehicles.


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So here we are…22 weeks pregnant! Another week has passed and I continue to trudge along with the every day routine we are accustomed to. I have a very full work week this coming week but I have the week off so if I can make it through the next 5 days then all will be well when I'm rewarded with weekend time with both of my boys. As in previous weeks, this week has passed by with not much change on the pregnancy front. The baby has suddenly started moving more regularly and I'm pretty sure I feel it many times throughout the day and definitely every day now…it's a really great feeling considering I didn't start feeling Jacob until after 24 weeks and Jacob was always more of a roller then a kicker. So far it seems that this baby is much like his/her big brother Jacob was in the womb because I don't feel much movement after 10pm and the baby is pretty still throughout the nights; I'm hoping this is a sign the baby will sleep through the night from an early age much like Jacob!
This week the baby is as big as a squash! Growing so much!
I'm feeling pretty decent lately and have no complaints aside from needing a bit more sleep. I'm looking forward to so much over the next three months so it's hard to be a negative nelly about pregnancy. I'm pretty sure at some point my body is going to get grumpy on me but for now I'm happy to be feeling so great! This week I am focusing on eating healthy and moving more! I have no appointments this week but I will report that I changed my next doctor's appointment from October 10th to the 14th because my doctor was going on vacation….at that appointment we'll get the paperwork for me to take my gestational diabetes test! What fun….blech.


text:
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text:
JOKER123 - Alice
Bet with those cute character in the Story Alice, help them find the road and they sure gift you with a huge jackpot as a rewards! But make sure don't make them angry while you put your bet!
JOKER123 - Beanstalk
Take the mighty Green Beans and climb up upon the cloud, the treasure you are looking for is lay inside the giant's Castle with the Giant Monster. Make sure you follow your leader who bring you to the top!


text:
Bus wreck memorial
- Details
- Category: School
- Published on 04 October 2019
- Written by Mount Vernon Optic-Herald
Dale Jordan speaks during the 60th anniversary memorial of the 1959 school bus wreck that killed eight people and injured many more.
He shared his experience during the wreck and helping remove survivors and injured classmates from the wreckage. Approximately 150 attended the event on Sunday, Sept. 29 at the Mount Vernon High School Lecture Hall.


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It might be a present for a newly married couple or for someone celebrating a birthday or anniversary–or simply to make a special person happy: a Gredič voucher is bound to show your loved ones or your customers just how much you appreciate them.
This gift voucher can be redeemed anywhere in Gredič. Be it for a wonderful overnight stay, a fine meal in the restaurant or for a degustation in the magnificent vinothèque.


text:
The Commission shall have no authority to establish a minimum retail price for milk, except upon a determination after a public hearing that the absence of a minimum retail price has caused or is about to cause a disruption in the Virginia milk market or some segment of the market that is likely to depress the producer price or has caused or is likely to cause a substantial reduction in competition between processor-distributors in an area, so as to adversely affect the public health and welfare that requires an adequate supply of milk at reasonable and fair prices. In accordance with the Administrative Process Act, § 2.2-4000 et seq. and in particular § 2.2-4002, the Commission may establish minimum retail prices on an emergency basis, prior to public hearing.The Commission, in establishing any minimum retail price when it deems it necessary to do so, shall impose a minimum retail price only for an area or political subdivision wherein the public interest as herein set forth justifies a minimum retail price being set and shall be guided by the same factors used in determining the reasonableness of prices under § 3.2-3208. The Commission shall periodically review all outstanding minimum retail price orders to insure that they do not remain in effect any longer than the public interest requires.
1974, c. 467, § 3.1-437.1; 2008, c. 860.


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After Chennai, Delhi is also facing alarming cases of disappearing groundwater. As per the Census of 2011, In India, only 32% of households have tap water supply from treated sources. Almost 18% of Delhi households do not have piped water supply.
Yet, this city has one of the highest percentages of households with piped water among all of India's states and union territories. Only seven of India's states and union territories have tap water supply in over 80 percent of households.
Meanwhile, in the national capital, which recently saw mercury rise above 48 degrees, "unauthorised colonies" like the ones in Devli, Badarpur and Dwarka are facing acute water shortages.
One of the conservationists said that Akshardham temple and Commonwealth Games Village is built on Delhi's water bank, thus the possibility of recharge of groundwater almost becomes nil.
Veena Khanduri, executive secretary of the non-profit India Water Partnership mentioned that the lost water bodies have been illegally turned into cremation grounds, temples, stadiums etc. This calls for the restoration of lost water bodies.
The remaining water bodies are in poor condition, filled with sewage and garbage dumped by residents and also deliberately by land sharks, or developers who want to encroach the land. The infiltration capability is said to have decreased from 15 percent to just 5 percent. Including heatwave action and a decrease in rainfall, there have been many stresses (on the groundwater). The situation seems very grim right now.
According to a NITI Aayog report, Delhi is among 21 major cities that will run out of groundwater by 2020. In a report by the National Geophysical Research Institute (NGRI) the groundwater levels in the city are depleting at an astonishing rate of 10 cm per year.
In order to replenish the groundwater, rainwater harvesting is compulsory but there are no compliance checks. Along with this, consumers also have to do more to check their water-usage practices.
Source: www.skymetweather.com
Image Credit: The Quint