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Today, George Osborne announced the results of the 2015 Spending Review, laying out the Government's spending plans for the rest of this Parliament. The £4.7 billion science budget is set to rise in line with inflation up to 2020.
Osborne also committed the Government to implement the recommendations of Sir Paul Nurse's Review of the Research Councils. When it comes to innovation the UK's innovation agency, Innovate UK, was given a flat cash settlement, with £165 million of its grants funding set to be converted to loans.
The science budget is protected in real terms…
In 2010, the science budget—the main pot of public money that funds research infrastructure and projects in the UK—was protected, but only in cash terms, meaning that it effectively declined over the course of the last Parliament. Today's announcement that it will now be pegged to inflation is therefore an improvement on the last settlement.
Osborne also today reiterated the Government's commitment to inflation-protect the £1.1 billion annual budget for science capital to 2021. Capital spending on science fluctuated over the course of the last Parliament, but with both capital and resource now set to rise with inflation for the rest of this Parliament, these interdependent budgets are now back in line and should be able to work together over the coming years. As Jo Johnson tweeted today, "batteries will now be included".
…but what's inside it?
Absent from today's announcements was any mention of a ring fence around the science budget, which has for the past five years protected it from being redirected to other areas. There was also no detailed breakdown given of what will be counted within it, ring fenced or not. However it has since been reported that the ring fence will remain, and that there will be no 'tucking in' to the science budget of other things, which would otherwise have meant the budget being spread more thinly.
While overall Government spending is set to decline, particular areas are protected. The Government is committed to spending 0.7% of Gross National Income (GNI) on Official Development Assistance (ODA), or foreign aid, and some of this will be made up by the inclusion of a £1.5 billion 'Global Challenges Fund' in the science budget over the next five years. That means that roughly £300 million of the £4.7 billion science budget each year will need to be spent in a way that "ensures UK science takes a leading role in addressing the problems faced by developing countries". This restriction may limit the way that some of the science budget can be spent.
Taking Nurse's prescription
Last week, Sir Paul Nurse's Review of the UK Research Councils, Ensuring a Successful UK Research Endeavour set out his vision for the future of the UK research system. I summarised the key points of that report in a previous blog, and today George Osborne announced that the Government intends to implement its recommendations.
This announcement means that although the overall budget looks stable, changes to the structures through which it is spent could be substantial. In the first instance, a new body, Research UK, will be introduced to work across the seven research councils to shape a strategic approach to science funding in the UK. The Government has also recently laid out its plans for changes to teaching in higher education in a green paper, on which they are now consulting.
Beyond the science budget in BIS
Several other bits of public funding for science and innovation are outside the science budget. Within BIS (the Department for Business, Innovation and Skills), Innovate UK, which funds innovation in businesses, received a flat cash settlement. Funding for its network of Catapult centres, which support collaboration between businesses and academics, is set to increase. However some of its grants funding for businesses will be turned into a loans-based model, to the tune of £165 million by 2019-20. Innovate UK's budget had increased steadily over the course of the last Parliament.
BIS also commits to funding aerospace and automotive sectors for ten years, and to doubling spending on apprenticeships since they came into office in 2010-11 by the end of the Parliament.
One document that didn't appear today is the Government's response to the Dowling Review, which made a number of recommendations for how the Government could better support collaborations between universities and businesses. That should be published soon, and will give a clearer picture of how Government plans to support innovation more broadly.
In higher education, there are several changes to make tuition and maintenance loans more generous, with STEM (science, technology, engineering and mathematics) subjects particularly favoured. Loans will be available for a second degree as long as it's in a STEM subject. Students in higher-level further education programmes will be eligible for loans, as will Masters students, and part-time students will get access to maintenance loans for the first time. On the other hand, maintenance grants are being replaced with loans (as announced in July). And the teaching grant allocated by HEFCE will be cut by £120 million – high cost subject funding (including STEM) will be protected, but responsibility for widening access will be pushed back onto universities.
Research in other departments
Departments across Government invest in R&D to inform their work but, as budgets declined across Government during the last Parliament, some departmental R&D budgets declined particularly steeply and disproportionately to other funding lines. In its Science and Innovation Strategy, published this time last year, the Government said that it would "examine how to ensure that R&D spending by departments is properly prioritised against other capital investment spending, for example by considering controls that can be placed on this spending to ensure that valuable R&D is not unduly deprioritised in favour of short-term pressures", by the Spending Review.
There was no sign of a cross-Government approach to this today, but there was some commitment to invest in research in other departments. 1.2% of the defence budget will be dedicated to science and technology over this Parliament, and a total of £5 billion will be invested in health research, including on antimicrobial resistance and the 100,000 genomes project, through the Department of Health. The Department for Energy and Climate Change will be doubling its innovation programme to £500 million over five years.
What happens now?
Today's announcements set the overall budget for UK research in this Parliament. Over the coming weeks, the details will become clearer about exactly how this funding will be divvied up between budgets within BIS and other departments. These specific allocations are the next piece of the puzzle.
With the spending settlement now in place, the research community and the Government will start to look at whether, how and when changes to the structures and governance of the UK research system will be implemented, particularly those recommended by the Nurse Review.
With the research base's attention now set to turn inwards it is worth remembering that, in the international context, the UK's research funding still pales in comparison to that of our competitor nations. Before the Spending Review, the Royal Society had called on Government to commit to increase public investment in research to match the OECD average of 0.67% of GDP; the UK currently invests 0.49%. For the UK to keep its place as a world leader in research, a long-term commitment to increase investment further will be required for the UK to keep pace with other knowledge economies.


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Let's talk a little marketing psychology. It is important for marketers in any industry to have a solid understanding of how our customers think, feel, and act. For hoteliers and hotel marketers, having a clear understanding of the travel shopping journey and what motivates our potential guests is priceless. Not only does it help us sympathize and address pain points during the travel shopping process, but also learn how to better communicate with shoppers during their evaluation and decision-making processes.
Though this complex and rather fascinating discipline can get rather granular when studying consumer behavior, there are several simple concepts that savvy marketers can easily master and implement into campaigns.
Goal: To understand what drives consumers' decisions and then optimize your hotel website to speak to key decision-making factors.
Outcome: To master a few key principles and take your marketing messaging from good to amazing.
In this article, we are going to cover 5 simple concepts that you can employ throughout your hotel's booking process to help positively influence sales.
1.) Social Proof
A concept that many people are probably already familiar with, social proof demonstrates that people view behavior correct if other people are doing it.
We see this often when our favorite sitcom plays a laugh track at the funny parts or when nightclubs limit entry to create a line outside.
From a hotel perspective, you can easily integrate this throughout your booking process with simple messages related to how many people are currently viewing a specific page or how many people have already booked a particular room or special. Furthermore, hotels can demonstrate social proof by showcasing relevant reviews or guest testimonials at different spots throughout the conversion funnel.
Hotel Messaging:
- Showcase how many people are currently viewing a particular page (Ex: 7 people currently viewing this room)
- Showcase how many people have already booked a particular room (Ex: 30 people have booked this room for January)
- Show guest testimonials throughout booking process (Ex: The staff was incredible and the room was immaculate – highly recommend!)
2.) Scarcity
The concept of scarcity simply states that humans consider a scarce object more valuable than one which is abundant. The rarer the opportunity or product, the more valuable it is. This is basic supply and demand and this condition has placed itself permanently in the minds of consumers.
There are some interesting studies behind the power of scarcity, including the "11,000 club" experiment. This "exclusive" club offered 11,000 people the opportunity to join the club for one exceptional benefit: the chance to be a member of the club. No information was given – people signed up just to join and be a part of the club.
Hotels can use messaging throughout the booking process to showcase a limited inventory or a limited time offer.
Hotel Messaging:
- Limited inventory → "Only 2 rooms left!"
- Limited time offer → "Only 12 hours left for reduced rates!"
3.) Urgency
Urgent situations cause us to suspend deliberate thought and to act quickly. Creating a sense of urgency will cut through cognitive friction and reduce the amount of time people spend considering alternatives – which is exactly what we want to do when encouraging travel shoppers to move through the conversion funnel.
The retail industry, in particular, has mastered this concept; just think about the shopping frenzy that surrounds annual holidays like Black Friday and Cyber Monday.
From a hotel perspective, there are several clever ways to incorporate messaging throughout the booking process to create a sense of urgency.
Hotel Messaging:
- Countdown Timers → "Only 2 days left" of a sale; "Rate guaranteed for 10 minutes"
- "Popular travel dates"
- "These dates old out last year"
4.) Anchoring
Anchoring describes the common human tendency to rely too heavily (or "anchor") on one trait or piece of information when making decisions – in this case, price.
How you are presenting your rates can help persuade consumers they are getting a great deal.
Anchoring is less about your actual pricing and package and about how you are presenting your rates. Creating context can by strategically anchoring your rates will produce a positive effect in relation to how your rates are perceived.
"The Economist" experiment is a notable demonstration of another closely related pricing tactic, "decoy" pricing. The publisher wanted to increase sales for their "print and web" subscription package, which was priced at $125, compared to only $59 for the "web only" package. When presented with only 2 options, 68% opted for the cheaper subscription. However, once The Economist employed a "decoy" price → "web only" = $59; "print only" = $125; "web and print" = $125 → 85% opted for the most expensive but "better deal" subscription.
All of this to say – pricing and presentation matter.
From a hotel perspective, be sure you are using a booking engine software provider that incorporates a few key design elements that allow different colors to be used, strikethrough pricing to be presented, and flexible packaging options to provide more value at a slightly higher price.
Hotel Messaging:
- "Regular rate" – slashed; lower rate below
- Packages (include breakfast, etc. for slightly higher – or even the same rate)
5.) Trust & Risk Mitigation
People want to trust your brand, trust that they are making the right choice, and trust that they are getting the best deal possible. Be sure to incorporate messaging throughout your booking process that will eliminate any doubts in the consumer's mind they might have about completing a booking with your property.
Amazon.com does a great job at establishing trust and mitigating any potential risk in the shopper's mind. The online retail giant showcases messaging related to product reviews, free shipping, and the ever-popular "Amazon Prime" 2-day delivery.
There are several simple messages that you can showcase throughout the booking experience to establish trust in the consumer's mind.
Hotel Messaging:
- Free cancellation
- No deposit required
- Free refunds
- Secure booking
- Upsell opportunity → Travel insurance/vacation protection plan
If there was any doubt that these simple concepts actually work, take a look at what travel giants are doing. Hilton Hotels, Marriott, and even the dreaded online travel agent sites already use these concepts throughout the research and booking process.
Booking.com is often referenced as one of the classic examples in the travel space that is doing it right. Complete a destination or hotel search on Booking.com's website and you will note an abundance of these tactics, and others, at work.
The simple truth is – this is what you are competing against. The travel giants have figured out what works and are using marketing psychology to help keep travel shoppers engaged and to nudge them through the decision making process.
Start small. Go through your booking process (on multiple devices!) and truly evaluate how it could be better. Then, have a conversation with your website and booking engine provider(s) to start testing the utilization of these simple yet effective messaging techniques.
Can Your Booking Engine Do That?
Ours sure can. The new and improved mobile-friendly Guest Desk Booking Engine was designed with hotel marketers in mind. Contact us today for a complimentary demo to see these 5 tactics in action!

subset: commoncrawl


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I know I'm quite late on the bandwagon of commentators of Rob Bell's "Love Wins" book, but I had a conversation with someone that made me think about it. A lot.
I didn't quite share my understanding of the book, so I thought: Let's make my next book review about something controversial.
Just a foreword: If you're looking for a hate post that dismisses "Love Wins" as a blasphemous book with half-truths in it, look somewhere else. For me, it was one of the books that transformed the way I see God and built His love into the foundation of my being.
Hell has been banished
There was a moment in Love Wins where the traditional concept and idea of Hell was shattered completely. I had this idea that only an exclusive handful of people, who believed the right set of things, got to enter the password at the end of their life and enter Heaven.
This concept though had its challenges for me.
Some of the questions that started popping up were:
- What about the billions of people who didn't know the password? (So to speak).
- Is a good God really going to punish people who has never had the opportunity to learn what the password is?
- What if my password isn't quite right, and I have a couple of characters missing?
Rob Bell systematically unpacked the scriptures and placed them in the Hebrew context. So, I can't put my finger on the parts that broke this open for me, but there was a peace and surety that came in that moment after following the scriptures and the train of thought.
I ultimately understood that there is no Hell. Only Heaven where God reigns over all peoples and creatures in a way that is harmonious and perfect.
That brought a deep, deep sense of relief and freedom from a lot of worries I had about the nature of God (and the afterlife).
Hold on, no Hell? Why follow Jesus?
Good news everybody! (I think). Truth cuts both ways.
In the same moment that the image of Hell was broken, I received a good and solid injection of fear of the Lord (yes, fear. Wisdom starts at fear, not "healthy respect").
I had a revelation of what Heaven will be like – God's perfect reign over all creatures where they do His will out of love and in submission. This revelation made me realise that I would be in a spot of trouble if I had to enter Heaven at this moment.
Please understand that I don't think I would be excluded, I know that the righteousness of Christ has been transferred to me through His sacrifice. I know that part of that sacrifice, through very mysterious ways, things in my life changes because of it. I know that I am saved by faith, through grace.
But I also know that there will be some bits of God's perfect reign I'll have trouble with. And that is why I need to take following Jesus seriously. It's why I need to deal with my sin and why I want to follow Jesus.
Why Heaven can be a Hellish place
So, imagine if you will, a place where there is no greed allowed. The type of place where the produce of the earth is shared equally, so that everyone will have no more than they need, and where no one will have less than what they need.
If I were to enter this place with an unwillingness to give up on my desire to have more than I need (aka greed), I'll likely feel as if I am in hell. In this hellish place I'll likely walk away from God and his perfect kingdom.
I'll also use racism as an example. If I entertain the racism in my heart, where my wilful choice is to always see another race as inferior to mine, I will not like Heaven all that much.
I'll walk in there, see people from the race that I hate and will, by choice, walk away from God and His perfect kingdom (Heaven).
See the pattern? God's Kingdom is perfect and follows His laws. The problem in the picture isn't the place He created and rules over, but the things in my heart I choose over His Kingdom.
And every time I choose to walk away from community and fellowship from God, God will let me because He will not override the very thing that He has given me to love Him. Every time I say, "My will be done", He will let it be done so.
As He lets my will be done, I will create a place of teeth gnashing and loneliness (unquenchable thirst) for myself. It will be my little kingdom, where I'm Queen and it will be a very, very miserable place.
That is why Heaven scares me a little, and that's a good thing because I've stopped taking my sin with a pinch of salt.
It's a good book. There is the pitfall where people could take sin less seriously because they've only gleaned the purpose of the book without digging into what the whole truth is.
I'd recommend it to anyone who has difficulties with the traditional views of Heaven and Hell.
If you're done reading it, and you're not left with a deep sense of freedom that includes a reverent, fearful, awe of the Lord, chuck what you've read in the bin.
Another good book to read for a good view on Heaven is The Great Divorce by CS Lewis. These two (Love Wins and the Great Divorce) has shaped the thoughts I've shared in this post.


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It's possible to travel over the famous Old Silk Road which Marco Polo had traveled at early days, sail at the stunning Mediterranean or enjoy the tropical cuisine in Turkey. Besides this, You May Also look the churches as well as also the Home of the Virgin Mary, also as mentioned in the Testament. Turkish Property Estate is wholly secular naturally, is stable and its own hospitality is famed, all explanations that you get inland in Turkey.
Turkey Property can be an excellent foreign investment whilst the funding increase rate is elevated; the rentals can be reasonably priced and also the investment involves really low hazard and is totally valid. You are able to opt to get in properties within this location to get much better investment choices.


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Mastering Your Blackberry Webinar training seminars presented by CareerTrack Seminars
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Training Course
Mastering Your BlackBerry® Webinar
1-Hour CareerTrack Webinar
The constant flow of information associated with your job can be intensely
overwhelming. From e-mail and calendar updates to instant messaging and Internet
overload, you are inundated with electronic forms of information that require
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You have to make an out-of-office visit, but that doesn't mean you still don't
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Shin Se Kyung, Nam Jo Hyuk, Krystal and Gong Myung join 'Bride of the Water God'
1. [+2216, -100] Typical miscasting. The crew doesn't understand the original characters
2. [+1823, -80] It's not easy to find as cast that doesn't matchㅋㅋㅋ
3. [+1400, -64] I don't know about the others, but don't you think Nam Joo Hyuk doesn't suits Ha Baek?
4. [+1378, -92] Already looking forward to a decline from the cast!
5. [+797, -36] Do you think Nam Joo Hyuk has the force to play the lead?
6. [+209, -7] I feel Nam Joo Hyuk suits being the good guy or the innocent college student. He's atmosphere is just different
7. [+161, -3] Changing the drama to the modern era really doesn't make sense, just go with the original
8. [+269, -42] Model turned actors Kim Young Kwang, Hong Jong Hyun, Nam Joo Hyuk, stop giving them the lead roles. They don't have a conscience.
9. [+171, -10] Just make a different drama with a different name.


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Toddler Tutu.
This adorable tutu is designed to fit toddlers. It'll be lots of fun for dancing or a child's party.
You will need a sport weight yarn, a 3.5mm crochet hook, and tulle.
If you enjoyed this free crochet pattern you might also enjoy more designs by Maz Kwok's Designs.


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All that said, it really is a lovely book (did I mention that it's pink?). Its message of gratitude first is one that speaks to me deeply. And it's a day-book which means that I can read it in small digestible bits of time that even I can do now with my two kiddos. But sometime ago, it joined the other dust-covered "self-help" books on my shelf (many promoted by Oprah, BTW). Please don't misunderstand me. There is nothing wrong with any of these books. I have even gotten good from them but at the heart, something was missing. Me. I was missing. I was looking outside of me. I wanted the act of reading the book to magically fix me. Looking back, I'm not even sure I know what needed to be "Fixed".
So back to Simple Abundance. It's a new year which always draws me to that shelf (and the corresponding one in Barnes & Noble) and its cover (you know, the pink one) caught my eye. So I revisited her. And in reading the Foreword, I found this quote front and center:
Often people attempt to live their lives backwards: they try to have more things, or more money, in order to do more of what they want so that they will be happier. The way it actually works is the reverse. You must first be who you really are, then do what you need to do, in order to have what you want. -- Margaret Young
I think that is the journey I'm on right now -- being who I really am, finding what I need to do, and doing it. So I'm taking Simple Abundance off the shelf for a whirl again. I'm not looking to be "fixed". Because I'm not broken. I've just been a little lost. And when you're lost, a map and a compass are pretty useful. And whether this book (or any other, for that matter) can provide a map remains to be seen. But I know this. I have a compass. I always have. It's my heart. And right now, we're heading to True North.


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Event Archive - Rock The Shores 2013: Weezer, Sam Roberts Band, Mother Mother, AWOLNATION, Vince Vaccaro, Reignwolf
Sun. July 14th 2013 - Sun. July 14th 2013 @ Juan De Fuca Recreation Centre - Lower Fields (All Ages)
General Admission Single-Day tickets for Saturday.:$59.50
Tickets at: Lyles Place, Ditch Records & Cds, Juan de Fuca Recreation Centre, All Ticketmaster Locations
Presented by: Atomique Productions, GOLDENVOICE
Event CategoriesMusic: Pop / Rock / Indie
ReviewsNo articles have been linked to this profile
Sam Roberts Band
Roberts formed the band that was eventually known as William in 1993. The band's name was changed to Northstar in 1996. Although the band gained some notice in independent rock circles, they couldn't break through to a national audience, and broke up in 1999 after failing to release an album.[1] Roberts' bandmate George Donoso went on to significan... more info
Mother Mother
The five-member modern pop band Mother Mother is creating some of the most exciting and expressive music being made in the country today. Hailing from Vancouver, Mother Mother's diverse sound and highly regarded live show has gotten them invited to a range of venues (they played the Montreal jazz festival, and at the Virgin Music Festival shared ... more infoArticles: MOTHER MOTHER: Word From Your Mother
Vince Vaccaro
Vince Vaccaro (born 1980) is a Canadian singer-songwriter, guitarist and record producer. He has performed largely as a solo artist, appearing both solo acoustic, and backed up by a five to eight piece band. His musical influences include Bruce Springsteen, Ben Harper, Eddie Vedder, Adam Granduciel, and Matt Mays. Vaccaro has played shows in ... more info


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Jun 01, 2014
Refreshing Kiwi Lime Slushy ~ Fruit Sweetened
This may very well be the most refreshing thing I've ever put in my mouth. Seriously revitalizing! It's a perfect way to cool off on a warm day. Filled with yummy goodness through and through. I felt like a little kid with a frozen, summer treat sipping on this!
I'm calling it a kiwi lime slushy since those are the flavors that are most prominent. But it's also chock full of honeydew melon (yum again) and frozen green grapes for a sweet-tart kick. A handful of fresh spinach leaves adds that bright green glow and some extra nutrients. Go ahead, cool your engines!
Healthy trails,
A cool, refreshing treat in the hot summer months!
- 2 cups coconut water
- 1 heaping cup frozen green grapes
- 2 heaping cups frozen honeydew melon chunks
- 2 kiwis, peeled
- zest and flesh of one organic lime
- Blend all ingredients in a high-powered blender until smooth and slushy!
2 responses to "Refreshing Kiwi Lime Slushy ~ Fruit Sweetened"
made this yesterday and drank it while sitting by the pool. Very good and refreshing!
Thanks for the feedback, Jen! 🙂


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Jimi Dining Table
Jimi is a statement piece, perfect for formal or informal dining spaces. Six individual frames of Cruzeta timber, reclaimed from old telephone poles, are stacked together in a geometric-inspired configuration, and support a furbished concrete slab. Cruzeta inlay detailing on top adds interest, and the rustic timber acts as a textural contrast to the smooth, cool grey concrete finish.


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Balloon In A Wasteland Unblocked
Balloon In A Wasteland Unblocked
DESCRIPTION: You were enjoying your flight when suddenly something went wrong with the balloon and you abruptly landed in the wasteland. In Balloon In A Wasteland Unblocked, you will have to use the weapons that you have or the ones that you get to shoot down all the creepy creatures that come to attack you. After finishing off each wave of enemies you must focus on repairing the flying machine.
INSTRUCTIONS: Arrow Keys to Move, Down key to heal the balloon.
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- Windows
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RationalPlan Project Server
RationalPlan Project Server 4.15 is free to download from our software library. This tool was originally created by RationalPlan Project Management Software. The most popular versions among the software users are 4.14, 4.11 and 4.1. RationalPlan Project Server belongs to Business Tools. Our antivirus scan shows that this download is clean.
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RationalPlan Project Server by Stand By Soft is a project management platform capable of handling multiple interrelated projects and concurrent user modifications. It is the best project management software solution for those that need to work as a team on common tasks and projects. It provides a centralized management solution for company projects while offering concurrent/controlled access for different users.
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Skip to 0 minutes and 0 seconds During the final week of this MOOC we will focus attention on natural products and molecular and cellular biology. In week 1 we heard how the era of molecular biology stems from the discovery of the double helical structure of DNA, and this led to huge scientific technological advances, that included technologies to quickly sequence genomes. We are going to hear how natural products often provide protection to the cells that produce them and also find out how discovery of some of them has been critical to our understanding of human health and disease. Some natural products have found important uses as antibiotics. In this area, significant discoveries identified penicillin and also streptomycin, the first antibiotic to be effective against tuberculosis.
Skip to 0 minutes and 51 seconds Since the middle of the twentieth century, advances in the molecular sciences have changed our understanding of how cells work. By 1968 scientists had interpreted how the genetic code links to protein synthesis and in the years that followed key regulators of the cell cycle were also discovered. One final example is 2015 Nobel Prize in Chemistry which was awarded to the biochemists Lindahl, Modrich and Sancar for their studies of DNA repair pathways. Now of course, there are some significant scientific advances that haven't been recognised by prizes or awards. Some of the most famous, that you may have heard of are a DNA profiling technique known as DNA fingerprinting as well as the cloning of the first animal in 1996, Dolly the sheep.
Skip to 1 minute and 47 seconds Recently, new and exciting technologies are allowing efficient and precise genomic modifications to be made in a wide variety of organisms and tissues. These new techniques are referred to as gene editing methods and they're starting to hit news headlines because of their potential to cure human diseases caused by mistakes or faults in human genes.
Timeline for biochemistry: natural products and the molecular sciences
During the final week of this course we focus attention on natural products and molecular and cellular biology.
Within week 1 we heard how the era of molecular biology stems from the discovery of the double helical structure of DNA, which led to huge scientific technological advances, including technologies to quickly identify genome sequences.
Some other significant biochemists and biochemistry experiments in these research areas include:
1929: Nobel Prize in Physiology and Medicine to Eijkman and Hopkins.
1937: Nobel Prize in Physiology and Medicine to Albert von Szent-Györgyi.
1945: Nobel Prize in Physiology and Medicine to Fleming, Chain and Florey for their work on penicillin.
1952: Nobel Prize in Physiology and Medicine to Waksman for his discovery of streptomycin, the first antibiotic that was effective against tuberculosis.
1968: Nobel Prizes in Physiology and Medicine given to Holley, Khorana and Nirenberg for their interpretation of the genetic code and its function in protein synthesis.
2001: Nobel Prizes in Physiology and Medicine to Hartwell, Hunt and Nurse for discovering key regulators of the cell cycle.
2015: Nobel Prize in Chemistry awarded to the biochemists Lindahl, Modrich and Sancar for their studies of DNA repair pathways.
It should also be remembered that not all significant scientific advances lead to recognition via Nobel prizes. Many important findings have yet to be recognised in this way, as illustrated by Jeffreys' reporting of a DNA profiling technique in 1984, which you may know of as "DNA fingerprinting", and the cloning of the first animal – Dolly the sheep – by Campell, Wilmut and colleagues in 1996.
Significant developments in gene editing methods continue to be made in recent years. New and exciting technologies allow efficient and precise genomic modifications to be made and they are referred to as "gene editing" methods. Among the most exciting of these is a revolutionary technology referred to as CRISPR-Cas9; many scientists have been involved in biochemical developments of this technique, including teams at different research institutes led by Charpentier, Doudna and Feng.
Further information about some of these findings and biochemists is available on the Biochemical Society website.
© UEA and Biochemical Society, 2018. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


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The initial structure of chondrule dust rims I: electrically neutral grainsOPEN ACCESS
C. Xiang, A. Carballido, R.D. Hanna, L.S. Matthews, T.W. Hyde
"In order to characterize the early growth of fine-grained dust rims (FGRs) that commonly surround chondrules, we perform numerical simulations of dust accretion onto chondrule surfaces. We employ a Monte Carlo algorithm to simulate the collision of dust monomers having radii between 0.5 and 10 μm with chondrules whose radii are between 500 and 1000 μm, in 100-μm increments. The collisions are driven by Brownian motion and solar nebula turbulence. After each collision, the colliding particles either stick at the point of contact, roll or bounce. We limit accretion of dust monomers (and in some cases, dust aggregates) to a small patch of the chondrule surface, for computational expediency. We model the morphology of the dust rim and the trajectory of the dust particle, which are not considered in most of the previous works. Radial profiles of FGR porosity show that rims formed in weak turbulence are more porous (with a porosity of 60-74%) than rims formed in stronger turbulence (with a porosity of 52-60%). The lower end of each range corresponds to large chondrules and the upper end to small chondrules, meaning that the chondrule size also has an impact on FGR porosity. The thickness of FGRs depends linearly on chondrule radius, and the slope of this linear dependency increases with time, and decreases with the turbulence strength. The porosity of FGRs formed by dust aggregates is ~20% on average greater than that of FGRs formed by single monomers. In general, the relatively high porosities that we obtain are consistent with those calculated by previous authors from numerical simulations, as well as with initial FGR porosities inferred from laboratory measurements of rimmed chondrule samples and rimmed chondrule analogs."


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Afro Funk 1969-1980
Take funk, soul, psychedelia and rumba, mix it up with a thick dose of heavy local rhythms and throw everything in a Benin grinder. The brew is then mixed up with hypnotic Farfisa solos, gritty guitar riffs, distorted bass lines, warm horns and the result, of exorcizing proportion, will lead to frenetic body movements. Some people bang their heads, others jerk their feet or feel an urgent need to get up and start shaking their hips.
One thing is common, though, to everyone who submits their ears to a spinning record by the mighty Orchestre Poly-Rythmo de Cotonou: you simply can't stand still. And this compilation is proof of that - here are 14 funky tracks by the legendary ensemble from Benin that has been deemed as 'West-Africa's best kept secret,' or as the 'The D.N.A. of voodoo groove'.
Orchestre Poly-Rythmo - The Skeletal Essences - 2LP
- Labels Analog Africa
- Product Code: AALP073
- Availability: In Stock


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Scorpio Technologies Networking Service Summary – Chennai India :
- Scorpio Technologies has been providing quality UNIX, Linux and Cisco services to small and medium sized businesses for the clients.
- Scorpio Technologies provide a broad range of UNIX administration and support service levels, including Onsite system administration, Disaster Recovery, remote secure system administration, 24/7 technical support through the technical support team
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- More than10 years experience in UNIX system installation, configuration, troubleshooting, and remote administration services.
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text: Prednisone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, endocrine problems, eye or vision problems, stomach or bowel problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. is it safe to purchase viagra online The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. This group of symptoms is called inflammation, and is caused by the body's immune system responding to the infection. Listing a study does not mean it has been evaluated by the U. Standard care for cellulitis is using antibiotics to destroy the infection, but the inflammation can persist and cause a great deal of pain. Cellulitis is the medical term for an infection of the skin, with symptoms including redness, swelling, warmth, and pain. The hypothesis of this study is that adding a single dose of an oral steroid (prednisone), which tempers the immune response, will reduce inflammation, reduce pain, and speed recovery. This hypothesis will be examined by recruiting a group of patients with cellulitis, and randomizing them to two sub-groups: one group will receive a dose of prednisone, while the other group will receive a placebo. Neither group will know what they received unless there is a problem. These subjects will be followed up at the 48 hour mark and the 7 day mark, and will have their results compared. Were to buy metformin Viagra songs Prednisone is available as a liquid, a concentrated liquid, and tablets of varying strengths. These include 1, 2.5, 5, 10, 20 and 50 milligrams mg, but 5 mg daily is the usual physiologic dose. can you buy prednisone over the counter in canada Prednisone is known to have numerous drug-drug interactions. In some cases, the secondary drug may increase the bioavailability, or absorption, of prednisone and, with it, the severity of side effects. In other cases, prednisone may interfere with the activity of the secondary drug. Drugs & Medications Prednisone Corticosteroids/Selected Macrolide Antibiotics Interactions This information is generalized and not intended as specific medical advice. I posted here in the begining of last month due to blood work results. since then I came down with a nasty bug that seemed to linger on so I went back to the doc. He gave me prednisone being that the epidural shots in the back did not help my pain. (Now the pain is really bad and going into the right hip.) He did another CBC which revealed that my WBC has risen from 12.1 to 16.8 with the ABS Neut count 12.0 and the ABS Lymph 3.9. I've had thyroid cancer with no treatment and wondering if maybe it has spread somewhere else? When I have taken prednisone, I feel awful for at least the first week or so. While on the prednisone and antibiotics, I seem to run a low grade fever towards later afternoon/evening and start feeling crumby. I figure, I will do the course of the treatment and if not feeling better, I'm going to ask for a referral! It does help the inflamation, but it takes a few days to have a positive effect. I thought a person should feel better after 48 hrs. I usually feel jumpy, uncomfortable, sick to my stomach, and just wierd when I have to take it. I can't really say anything about whether the fever is related to the prednisone or not though, because I tend to run fevers often for no apparent reason. If you still feel no improvement from the symptoms of your infection in 3 more days, you should call the Dr. I'm 22, and have recently been diagnosed with a nasty case of scabies, little mites that burrow into your skin, leaving their own eggs and waste, eventually forcing their human host (me) into a very sensitized state of histemia, leading to somewhat of an itching crisis (forgot the nerdy word for 'itching') that can last for weeks upon weeks, even after the parasite is dead. Looooong story short, after covering myself with insecticide cream prescribed to me by the second doc, going to Santa Barbara for Halloween weekend (and I must add for those who would appreciate it, somehow, drunkenly finding my way into the ladies' room at a crowded bar on that Saturday night, with two hot, young sisters, and two other cute females, *edit..., *edit..., *details only I will know, but you can dream about! ), um anyways by time I had gotten back, this rash that was once thought to be scabies was worse. I was itching all over, it had even spread to my face. Needless to say, I did not have them scabies, but some sort of infection! My immune system was so whacked out by whatever was invading my skin and blood that it had essentially began to invade the rest of my body. So I saw five doctors today and ended up with a scrip to a powerful antibiotic, and a tapered dose schedule of prednisone starting with 60mg, once, daily, for five days, then dropping to 40mg once/day/5days, etc. Prednisone with antibiotics Do probiotics interfere with prednisone - Will. Answer, Benefits and Risks of Prednisone - Buy obagi tretinoin cream 0.1 Prednisolone, antibiotics and probiotics ? Follow. Posted 2 years ago, 8 users are following. I have severe gastritis and H. Pylori so soon have to start treatment with 4 antibiotics in the space of 10 days. Prednisolone, antibiotics and probiotics ? Polymyalgia. Corticosteroids/Selected Macrolide Antibiotics Interactions Antibiotics and Prednisone for Radiesse Problems Doctor Prednisone is a steroid that works in a similar way to cortisol, which is the hormone normally made by the body's adrenal glands. Steroids are used to treat a wide range of conditions from. amoxicillin 500mg dosage Prednisone is a corticosteroid cortisone-like medicine or steroid. It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. This medicine is available only with your doctor's prescription. Interactions of prednisone, Mucinex ®, amoxicillin, and Z-Pak® Prednisone, Mucinex®, and antibiotics are commonly prescribed together. There is a low potential risk for an interaction between.


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Dr Andrea McDonald, Dr Cristina Cleghorn, Prof Nick Wilson, Prof Tony Blakely
Last month the British Medical Journal published a study on the highly anticipated purchasing data examining the impact of taxing sugar sweetened beverages (SSB) in Mexico (1). This study reported that the 10% tax on SSBs was associated with an overall 12% reduction in purchases and a 4% increase in purchases of untaxed beverages one year after implementation. In this blog we examine this latest study, how it fits in with existing evidence, and how these results might apply to improving the control of obesity and improving child oral health in New Zealand.
From 1 January 2014, Mexico implemented an excise tax of 1 peso per litre on sugar sweetened beverages. This newly published study (1) reports that a 10% tax on SSBs was associated with an overall 12% reduction in purchases and a 4% increase in purchases of untaxed beverages, one year after implementation. These findings deserve to be looked at carefully given the growing international interest in taxing unhealthy foods. SSB tax is recommended by the final report from the Commission on Ending Childhood Obesity (ECHO) published 25 January 2016 (2), as one of a range of measures to address the environment causes of overweight and obesity requiring greater political commitment.
How was the Mexico study done?
The study addressed a clearly focused question; to evaluate changes in the purchases of consumer beverages after the implementation of the excise tax by using scanned and recorded individual food purchase data (Nielsen Mexico Consumer Panel Service).
The SSBs that were taxed included carbonated fizzy drinks and non-carbonated SSBs such as flavoured water and sweetened fruit juice. Untaxed beverages were carbonated drinks such as diet fizzy drinks; sparkling, still, or plain water; and other drinks, including unsweetened dairy beverages and 100% fruit juices with no added sugar.
The study was urban based. A representative group of Mexican households was recruited and then followed up from January 2012 through December 2014. The eligible population represented 63% of the Mexican population (i.e., those living in cities with more than 50,000 residents) and 75% of food and beverage expenditure. The authors weighted the results for household composition, locality and socioeconomic position to match demographic estimates.
Because of seasonal (more SSBs drunk in Mexico in summer) and long-run trends in SSB consumption (e.g., a pre-tax trend of decreasing consumption levels for reasons other than tax), it is vital that an analysis of SSB tax impact compares post-tax consumption with what consumption would have been based on past trends continuing – not a simple before-after comparison. Therefore the authors modelled a counterfactual consumption as though the tax had not been imposed. Specifically, they used a pre post quasi-experimental approach using "difference-in-difference analysis" and a "fixed effects model" that has the advantage of accounting for non-time varying unobserved characteristics of households (for example, preference for certain types of beverages). The model also adjusted for time varying confounders: unemployment rates and minimum income levels. However, it was not possible to adjust for changes in health promotion activities that could also have changed SSB consumption. For example, there were health campaigns about sugary beverages, anti-obesity programmes and economic changes occurring simultaneously that were unable to be accounted for.
What were the results in more detail?
The 10% tax on sugar sweetened drinks in Mexico was associated with a 12% reduction in purchases of drinks included in the tax, and a 4% increase in purchases of untaxed beverages a year after implementation. The impact increased over time and the most disadvantaged groups had the greatest reduction in SSB consumption. The tax was considered to be 'pro-equity' as would be expected given the evidence that lower income people are more price sensitive (see blogs from 2013 and 2014). This matters because SSB consumption, obesity, diabetes and other non-communicable diseases (NCDs) are strongly socially patterned. A greater impact on consumption in the most disadvantaged groups leads to greater potential health gains in these groups and greater health inequality reduction.
Figure 1 from the study in the BMJ (1) shows the volume of consumption tracking over time for taxed SSBs (top) and untaxed beverages (bottom). At the beginning of 2014 a red line shows the modelled consumption expected without the tax (counterfactual). The green line shows the observed beverage consumption, and how on average, a person living in a Mexican city purchased 4.2L less of taxed beverages.
The differences between observed consumption and the counterfactual were highly statistically significant – it was after all a large sample. So the findings are almost certainly not due to 'chance'. The main remaining source of bias, though, is the inability to control for time-varying confounding – especially changes in health promotion and the level of industry promotion of SSBs. The authors appropriately suggest that more work is needed here. However, by using the counterfactual approach – of estimating what consumption would have been in the absence of tax – trends in consumption that reflect trends or 'ongoing levels of other drivers influencing SSB consumption' are probably taken into account. Put another way, as long as the net impact of health agency and industry activity to (dis)encourage SSB consumption was much the same before and after tax, the results should be valid. Our assessment is that potential residual confounding that might overturn this study's main findings is unlikely (though it cannot be ruled out). Furthermore, health campaigns introduced in conjunction with a tax can be a valid option from a public health perspective (if cost-effective), as these may strengthen the impact of a SSB tax on reducing consumption and optimise public acceptability.
The results of this study are consistent with modelling (3) (see a previous blog on Australian modelling), beverage sales data (4-6), and pricing data. Pricing studies have demonstrated how the SSB tax was passed along to consumers for all SSBs and for carbonated SSBs the extra price consumers paid after the tax was introduced was more than the 10% tax introduced (over-shifting) (7). Study results are also consistent with the very well established results internationally for other health-related taxes on tobacco and alcohol. Further monitoring in Mexico and case studies from other countries would further inform the evidence around SSB taxation and clarify the long-term impact of the tax, potential substitutions and its overall health implications.
How might the results apply to New Zealand?
New Zealand has some of the highest adult obesity rates in the OECD (at 31%), like Mexico (at 32%). The level of SSB consumption at the national level is substantial in Mexico and New Zealand (quoted as 163L per person in Mexico and 115L in New Zealand, Euromonitor International). Furthermore, both SSB consumption and obesity are strongly socially patterned, suggesting greater potential benefit from SSB taxes for those with the greatest rates of obesity-related disease. Mexico has introduced a wide suite of interventions that are expected to work together to reduce SSB consumption; including restricted sales of calorie-dense foods in schools, limited airtime for junk food advertisements on children's TV programmes, and a special tax on packaged snacks. We suspect that introducing a SSB tax could be an important component of a comprehensive government strategy to help fix the obesogenic environment in New Zealand and to also improve oral health for both children and adults. Such a tax could complement policies to restrict sales of calorie-dense foods in schools and to restrict junk food advertisements to children on all media as recommended in the ECHO Report. The extra tax revenue could be used to fund child health initiatives such as expanded fruit provision in schools, provision of healthy school lunches, or expanded dental services (see a previous blog on SSB tax implementation) as has been done in other settings.
- Colchero MA, Popkin BM, Rivera JA, Ng SW: Beverage purchases from stores in Mexico under the excise tax on sugar sweetened beverages: observational study. BMJ 2016, 352:h6704.
- World Health Organization: Report of the Commission on Ending Childhood Obesity. In. Geneva, Switzerland: World Health Organization; 2016: 1-50.
- Colchero MA, Salgado JC, Unar-Munguia M, Hernandez-Avila M, Rivera-Dommarco JA: Price elasticity of the demand for sugar sweetened beverages and soft drinks in Mexico. Econ Hum Biol 2015, 19:129-137.
- Guthrie A: Mexico soda tax dents coke bottler's sales: Coca-Cola Femsa says Mexican sales volume has fallen more than 5% this year. Wall Street Journal 2014.
- Case B: Soſt-drink thrist quenched by Pena Nieto tax: corporate Mexico. Bloomberg News 2014.
- Gallucci M: As Mexico's sugary drink tax turns 1 year old, US health proponents hope it can sway American voters. International Business Times 2015.
- Colchero MA, Salgado JC, Unar-Munguia M, Molina M, Ng S, Rivera-Dommarco JA: Changes in Prices After an Excise Tax to Sweetened Sugar Beverages Was Implemented in Mexico: Evidence from Urban Areas. PLoS One 2015, 10(12):e0144408.


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Product Description
A perfect shade of red for any occasion! Can be used on your lips, cheeks and eyelids.
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A little goes a long way. Put a drop or two onto your finger and apply to desired area.
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Hello everyone! I hope you are all doing well and having a wonderful weekend so far! Today I am sharing another slow cooker recipe for a dish that I made earlier this week...
Crock Pot Sante Fe Chicken.
You may remember the post I wrote a few weeks back called Mealtime Simplified, where I shared my love of making meals with the slow cooker, along with some recipes for dishes that I had already made, or would be making in the near future. Several of you also shared your own slow cooker recipes in the comments section, as well as different cooking sites that also have a plethora of recipes to be made using the slow cooker method, and for that I say THANK YOU! The chicken recipe I'm sharing today actually comes from one of those sites called skinnytaste, and it is not only incredibly delicious, but very easy to make, too. :)
Crock Pot Sante Fe Chicken:
This dish consists of slow cooked shredded chicken with corn, tomatoes, and black beans served over rice or in a bowl with nachos on the side. It's topped with chopped scallions, fresh cilantro, cheddar cheese, sour cream, and you can even add a dollop of salsa for extra added flavor if you like. It is very kid-friendly (my boys loved it), freezer friendly, and gluten-free. Made as is, the recipe yields 8 servings, but you can adjust it to make more or less depending on the size of your family and personal needs.
24 oz (1 1/2) lbs chicken breast
14.4 oz can diced tomatoes with mild green chilies
15 oz can black beans
8 oz frozen corn
1/4 cup chopped fresh cilantro
14.4 oz can fat free chicken broth
3 scallions, chopped
1 tsp garlic powder
1 tsp onion powder
1 tsp cumin
1 tsp cayenne pepper (to taste)
salt to taste
Combine chicken broth, beans, corn, tomatoes, cilantro, scallions, garlic powder, onion powder, cumin, cayenne pepper and salt in the crock pot. Season chicken breast with salt and lay on top.
Cook on low for 10 hours or on high for 6 hours. Half hour before serving, remove chicken and shred. Return chicken to slow cooker and stir in. Adjust salt and seasoning to taste. Serve over rice or tortillas and your favorite toppings.
That's it...easy peasy, and the result is an incredibly delicious meal that the entire family is sure to love! :)
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Saturday, May 3, 2014
Cooking Simplified: Crock Pot Sante Fe Chicken
4 comments:
I'm just making out my grocery list and here is the perfect recipe. Monday is cinco de mayo!ReplyDeleteReplies
This is such an easy and delicious recipe, Desert Flower. I'm sure you will love it, plus it's a good one to start giving your slow cooker a try with. :)Delete
This looks great. I have not used our slow cooker enough because I can barely eat in the morning and raw meat kind of makes my skin crawl. Lately, though I've prepped everything the night before and put it together in a zip lock bag or pyrex bowl so I can just plop everything into the slow cooker in the morning. BBQ pulled pork and southwestern pulled chicken are always a hit - so after BBQ season I'm determined to try more slow cooker recipes.ReplyDeleteReplies
Hi JulieStyles! This really is such a delicious dish...you should definitely give it a try. I use our slow cooker on a weekly basis, since it's just so easy to throw in items for a meal and not have to worry about it until dinnertime. Let me know what you think if you decide to try this recipe out! :)Delete