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Phillips Charitable Organizations is committed to helping individuals from underprivileged backgrounds to realize their dreams. As part of its mission, the nonprofit provides grants to help aspiring engineering students pursue a higher education, recognizing that many obstacles often stand in the way of aspiring STEM professionals.
For many students, one of the most significant barriers to success in STEM is personal motivation and self-esteem. The perceived difficulty of STEM subjects is one of the primary obstacles that dissuades many students from pursuing a career in science, math, engineering, or technology. For many students, the lofty accomplishments of the world's greatest scientists can make even a rudimentary understanding seem out of reach. However, a recent study found that by offering a little more insight into the lives of famous scientists, educators can inspire students to explore STEM fields.
Surmounting Obstacles
The study tracked 402 students attending the 9th and 10th-grade in the Bronx and Harlem boroughs of New York City. While one group of students simply learned about the scientific accomplishments of great minds such as Albert Einstein and Michael Faraday, another delved more in depth, focusing on the personal struggles that these scientists faced, such as poverty and religious persecution. A third group explored the professional obstacles that lined these individuals' paths to success, such as unsuccessful theories and experiments. At the conclusion of the study, the students who had gleaned a fuller understanding of the scientists' success were more likely to have improved their grades.
By teaching students about the accomplishments—as well as the failures and struggles—of great scientists, educators can help to humanize STEM heroes in the eyes of youth. With the understanding that genius is rarely innate, but instead the result of hard work and determination, youth may discover that they, too, are capable of pursuing STEM careers.
Following are some of the most celebrated scientists whose accomplishments resulted from perseverance in both their personal and professional lives.
Michael Faraday
In spite of humble beginnings that prevented him from pursuing a higher education, Michael Faraday leveraged his passion for knowledge to guide him to great heights. Born in 1791 in South London to a family from economically disadvantaged circumstances, he received a basic education at Sunday school before becoming an apprentice to a bookbinder at the age of 14. Faraday used this opportunity to further his education and pored over many of the scientific texts that passed through the shop. After attending a series of lectures by chemist Sir Humphry Davy, an inspired Faraday submitted his extensive scientific notes to Davy, requesting a job. Although he was initially denied, an opening on Davy's staff brought Faraday to the Royal Institution as a chemical assistant one year later.
Faraday's passion and initiative paid off. As Sir Davy's assistant, he had an opportunity to expand his scientific knowledge and network with the international scientific community. In 1821, Faraday published his theory on electromagnetic rotation, which would inform such noteworthy inventions as the electric motor. His later research revealed the phenomenon of electromagnetic induction, which was instrumental in the effort to harness electricity as a powerful tool. To this day, the unit of electrical capacitance carries the name farad in his honor.
Marie Curie
While Michael Faraday overcame the trappings of financial status to pursue scientific innovation, Marie Curie pressed on through societal norms that kept women out of the academic sphere. Born in 1867 in Warsaw, Poland, Madam Curie excelled in her early educational career and discovered a passion for science under the tutelage of her father. Since Polish universities did not welcome women at this time, she traveled to France to continue her studies at the Sorbonne. It was here that she met her future husband, physics professor Pierre Curie.
Marie Curie worked alongside her husband to expand the scientific understanding of radioactivity following its discovery in 1896. Working on modest teachers' salaries, the pair often conducted their research in less-than-ideal laboratory environments. Despite this, Madam Curie successfully isolated radium from radioactive residue, which allowed her to explore the element's properties and potential therapeutic applications.
Marie Curie and her husband received the Nobel Prize for Physics in 1903. After his passing in 1906, Marie Curie carried on his legacy as the Sorbonne's first female Professor of General Physics, also becoming the director of the Curie Laboratory at the University of Paris' Radium Institute. Continuing her research into radioactivity, she earned her second Nobel Prize for Chemistry in 1911. For the remainder of her life, she was a leader in the scientific community, serving on the Committee of Intellectual Co-operation of the League of Nations.
George Washington Carver
Although he was born into slavery, George Washington Carver would go on to become one of the most influential agricultural scientists in American history. Historians generally place his birth date in 1864, shortly after which criminals kidnapped and sold him and several of his family members in Kentucky. Once located and returned to the Carver family, George Washington Carver learned how to read and write from the family's matriarch, who furnished him with the education that local schools refused to provide to black children. Undaunted by the racist realities of 19th-century academia, Carver went on to graduate from high school and apply to college. Initially denied acceptance due to his race, he took charge of his own education and ran a homestead where he conducted biological, geological, and botanical research.
After discovering that he had an aptitude for botanical drawing, Carver earned a spot at Iowa State Agricultural College, where he received both his bachelor's and master's degrees. Subsequently, he received an invitation to oversee the agricultural department at the Tuskegee Institute. Here, George Washington Carver undertook his most celebrated experiments, discovering hundreds of new applications for crops, including soybeans, pecans, and sweet potatoes. However, he is perhaps best known for the numerous new products he synthesized from peanuts, including dyes, soaps, cosmetics, and even gasoline. His innovations not only helped to revitalize the agricultural economy of the post-Civil War south, but they influenced agricultural research for decades to come.


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Well, this should be no surprise. Reuters reports what we've suspected all along because there's a long history of this happening: Low gasoline prices are negatively impacting the sale of alternative fuel vehicles including those running on natural gas and
I was changed by the 1990 introduction of the GM Impact electric car prototype at the Los Angeles Auto Show, then again by the amazing array of electric, hydrogen, and 'green' vehicles I witnessed at the 1991 Tokyo Motor Show.
It is an exciting time to be involved with the auto industry, or to be in the market for a new car. The auto industry has responded splendidly to the challenge of new emission, fuel economy, and safety standards. The
While drivers in many other countries can choose from dozens of passenger car models operating on compressed natural gas (CNG), that's not the case here. We have one: Honda's Civic Natural Gas. That changes with the coming 2015 Chevrolet Impala
Ford's 3.7-liter V-6 equipped-150 pickup is now available with a factory-installed, gaseous-fuel prep package, making Ford the only manufacturer offering a CNG/LPG-capable half-ton pickup. The $315 engine prep package includes hardened valves, valve seats, pistons, and rings so it can
We are all enamored by the advanced technologies at work in vehicles today. And why wouldn't we be? The incredibly efficient cars we have today, and the even more efficient models coming in the years ahead, are testament to a
About a year ago, I gathered all our employees for a meeting and proceeded to make one bold statement, and an even bolder prediction. I shared my deep conviction that we were at the forefront of a historic opportunity within
In the 1990s amid all the activities surrounding electric vehicles, there were natural gas vehicles (NGVs) being sold by automakers, primarily pickups and vans aimed at fleets. It was a good start for natural gas. Unfortunately, the changing whims of
Car rental giant Hertz will begin offering compressed natural gas (CNG) vehicle rentals to customers at Will Rogers World Airport in Oklahoma in early May, serving as a pilot program for the company's CNG airport rental activities. Initial natural gas
Powered by propane autogas (LPG), the Maxximus LNG 2000 has set three new world records at South Georgia Motorsports Park, according to Fisher Island, Florida-based Centaur Performance Group. These latest record attempts follow additional world records set in January with

subset: commoncrawl


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BYT is having a casting call in order to advance its coverage of everything awesome in the DC area.
(and beyond)
We aren't talking about just music.
If you want to write about literature and Olsson's book signings, we want you.
Food/Wine reviewers-we want you.
If you're stylish and crafty, we want you.
If you're a struggling photojournalism grad who can rock a Canon 30D at a concert (or any other event, really), we want you.
Rinse and repeat ad nauseum:
if you want to write about something that you think would interest us, we want you.
The caveat is this: BYT is a labor of love. If you're doing this to "get those phat stacks of cash, son," well, go sell crazy someplace elsewhere. We aren't interested. We want someone who can be dedicated to the cause, and contribute something once a week (ideally – but more is encouraged, obviously).
What you WILL get out of contributing to BYT:
– A creative outlet for you to release all those metaphors you've been building up (without jacking off all over a thesaurus like a Pitchfork staffer).
– Exposure to new music and shows – the BYT crew is pretty good at taking care of each other in this regard.
– And a chance to ask artists the tough questions – like if masturbating will make you go blind. There's no holding back.
If this sounds good, pick up the following shit, and send it to
[email protected]:
– Any previous clips you've got. College paper? Freelance? If you don't have anything, whip up a review of a current record/movie/book/restaurant/street corner BYT hasn't written about yet.
– What you would contribute to BYT that would elicit that new, fresh, Selsun Blue tingly feeling.
– Story ideas, including some that don't pertain to MUSIC. Food, dance, design, literature, art, fashion – send something about that avenue as well.
– A resume? If you've got it, send it, otherwise, don't sweat it.
There's no real deadline for this, but the sooner the better!


text: The Dragon Riders earn the trust of another tribe and form an alliance against Viggo, who's busy creating a new secret weapon: Project Shell Fire. Dagur the Deranged escapes from prison and ventures in the uncharted territories to build an armada against Hiccup and his Dragon Riders. Coming across a cylinder (christened "Dragon Eye") that provides information on the uncharted territories, Hiccup and his quirky team search the region looking for both Dagur and hitherto unknown species of dragons, eventually leaving Berk to build for themselves a new and distant base of operations called Dragon's Edge.


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Paladins are indomitable warriors who've pledged their prowess to something greater than themselves. Paladins smite enemies with divine authority, bolster the courage of nearby companions, and radiate as if a beacon of inextinguishable hope. Paladins are transfigured on the field of battle, exemplars of divine ethos in action.
To you is given the responsibility to unflinchingly stand before an enemy's charge, smiting them with your sword while protecting your allies with your sacrifice. Where others waver and wonder, your motivation is pure and simple, and your devotion is your strength. Where others scheme and steal, you take the high road, refusing to allow the illusions of temptation to dissuade you from your obligations.
Take up your blessed sword and sanctified shield brave warrior, and charge forward to hallowed glory!
Class Traits
|Role: Defender. You are extremely durable, with high hit points and the ability to wear the heaviest armor. You can issue bold challenges to foes and compel them to fight you rather than your allies.
Power Source: Divine. You are a divine warrior, a crusader and protector of your faith.
Key Abilities: Strength, Charisma, Wisdom
Armor Proficiencies: Leather, hide, chainmail, scale, plate, light shields, heavy shields, cloth.
Hit Points at 1st Level: 15 + Constitution Score.
Trained Skills: Religion. From the class skills list below, choose 3 more trained skills at 1st level.
Build Options: Avenging Paladin, Protecting Paladin.
Creating a Paladin
Paladins rely on Strength, Charisma, and Wisdom for most of their key abilities and powers. Constitution is useful as well, although no paladin powers are specifically based on Constitution. Paladins start with two common builds: the avenging paladin and the protecting paladin.
Avenging Paladin
You burn with the desire to punish the wicked and smite the unbelievers. In your view, the best way to safeguard your allies is to destroy your enemies with divine power and overwhelming attacks. Choose Strength as your highest ability score, since your most damaging attacks are based on Strength. Charisma should be your second-best ability score, and Wisdom your third. Consider wielding a big two-handed weapon such as a greatsword or greataxe, and choose powers that deliver the highest amount of damage.
Feat: Power Attack (Human Feat: Human Perseverance)
Skills: Endurance, Heal, Intimidate, Religion
At-Will Powers: holy strike, valiant strike
Encounter Power: radiant smite
Daily Power: paladin's judgment
Protecting Paladin
You emphasize defense, guarding your allies, and healing and bolstering them with a few of your powers. You do not deal as much damage as the avenging paladin, but you are better at dealing with a wider array of situations. Your best ability score should be Charisma. Choose Strength for your second-best score (you'll want a few Strength-based attacks), and Wisdom as your third-best score. The protecting paladin works best as a shield-carrying warrior, so you should probably use a heavy shield and a one-handed weapon such as a longsword or a warhammer. Select powers that help your allies, along with a few damage-dealing powers for when the need arises.
Feat: Healing Hands (Human feat: Action Surge)
Skills: Diplomacy, Heal, Insight, Religion
At-Will Powers: bolstering strike, enfeebling strike
Encounter Power: shielding smite
Daily Power: radiant delirium
Paladin Class Features
Your armor, your shield, and your weapon are the most important tools of your trade. In addition, you have the following class features.
Channel Divinity
Once per encounter you can invoke divine power, filling yourself with the might of your patron deity. With the divine might you invoke you can wield special powers. You can also learn other uses for this feature; for instance, the divinity feats in Chapter 6 grant characters with access to the Channel Divinity class feature the ability to use additional special powers.
Regardless of how many different uses for Channel Divinity you know, you can use only one such ability per encounter. The special ability or power you invoke works just like your other powers.
Divine Challenge
The challenge of a paladin is filled with divine menace. You can use the divine challenge power to mark an enemy of your choice.
Lay on Hands
Using the lay on hands power, paladins can grant their comrades additional resilience with a touch of their hands and a short prayer, though they must give of their own strength to do so.
Paladins and Deities
As fervent crusaders in their chosen cause, paladins must choose a deity. Paladins choose a specific faith to serve, as well as an alignment. You must choose an alignment identical to the alignment of your patron deity; a paladin of a good deity must be good, a paladin of a lawful good deity must be lawful good, and a paladin of an unaligned deity must be unaligned. Evil and chaotic evil paladins do exist in the world, but they are almost always villains, not player characters.
Paladins are not granted their powers directly by their deity, but instead through various rites performed when they first become paladins. Most of these rites involve days of prayer, vigils, tests and trials, and ritual purification followed by a knighting ceremony, but each faith has its own methods. This ceremony of investiture gives a paladin the ability to wield divine powers. Once initiated, the paladin is a paladin forevermore. How justly, honorably, or compassionately the paladin wields those powers from that day forward is up to him, and paladins who stray too far from the tenets of their faith are punished by other members of the faithful.
Paladins make use of holy symbols to help channel and direct their divine powers. A paladin wearing or holding a magic holy symbol can add its enhancement bonus to attack rolls and damage rolls to powers that have the implement keyword. Without a holy symbol, a paladin can still use these powers, but he or she doesn't gain the bonus provided by the magic implement.
A holy avenger, a special magic weapon, can also be used as an implement for paladin powers, as well as paladin paragon path powers. These weapons are highly sought after by paladins.
|Character Classes
|Player's Handbook
|Cleric ✦ Fighter ✦ Paladin ✦ Ranger ✦ Rogue ✦ Warlock ✦ Warlord ✦ Wizard
|Player's Handbook 2
|Avenger ✦ Barbarian ✦ Bard ✦ Druid ✦ Invoker ✦ Shaman ✦ Sorcerer ✦ Warden
|Player's Handbook 3
|Ardent ✦ Battlemind ✦ Monk ✦ Psion ✦ Runepriest ✦ Seeker
|Artificer (Eberron Player's Guide) ✦ Swordmage (Forgotten Realms Player's Guide)
|Character Classes


text:
Okay, thanks guys I'm gonna pull that right now and play with it
BUG. Notifications are read during the transition to the profile
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Thanks! gh#3370
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text:
A selfie stick and Stand is used to take photographs or video by positioning a dig...
A selfie stick and Stand is used to take photographs or video by positioning a digital camera device, typically a smartphone, beyond the normal range of the arm. This allows for shots to be taken at angles and distances that would not have been possible with the human arm by itself. The sticks are typically extensible, with a handle on one end and an adjustable clamp on the other end to hold the device in place. The rubberized ring & foot grips provide extra gripping power to grapple and wrap around almost any surface. With the quick-release plate it makes setup a snap. It is ultra-portable. Whether you're shooting time-lapse photos with your mobile or capturing videos with your camcorder, this excellent Mini flexible tripod is the perfect companion to your next great adventure.Socheko.Com provide you Selfie Stick at best price Nepal. There is various color and various brand of selfie stick in Socheko.Com like the black, blue, white etc.And Genuine Brands like Mpow Selfie Stick, Fugetek FT-568, Spigen Velo S520W, JETech Battery Free Selfie Stick, Gorilla pod Tripod.
In the various size 5inch, 8inch, 9inches etc. Buy the genuine Selfie Stick at Best price of Nepal in Socheko.Com online shop We can deliver the product as soon as possible. In Kathmandu valley we can deliver the product in two hour and for the order of outside valley or Kathmandu we take 1 day to deliver the item. You can easily trust to us because Socheko.Com is promoted by Nepal's renowned business group who has been in Nepal business arena for last 20 years. We have understand value of customer and always believe on customer comes first. Socheko dot Com provide you the most genuine Selfie Stick at Best price Nepal. It becomes an indispensable commodity when you being out for holiday then selfie stick help you to capture the most beautiful photos for the memory so buy the Selfie Stick from Socheko.Com and make your life happy.
End of product listing


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Starlight Room
Starlight Room - a letter from Santa! (1 images)
Lilly and Tia from Year 2 are very excited to have received a letter from Santa, delivered from the North Pole. "We have had fun making lots of Christmas decorations with plenty of glitter!!"
Created: 18 Dec 19 10:11 | Last modified: 18 Dec 19 10:12
Starlight Sunglasses! (3 images)
In Starlight we are celebrating summer by making our own sunglasses, we had a lot of fun & thought they looked rather snazzy! Also we celebrated Leighton's birthday with cake and party ring biscuits. We wish all the children a happy summer holidays.
Created: 28 Jun 19 10:12 | Last modified: 28 Jun 19 11:26
Meditation sessions (2 images)
Alfie & Tanisha Y3 have enjoyed our new meditation sessions, we have enjoyed learning new techniques, helping us to keep calm
Created: 3 Apr 19 11:43 | Last modified: 3 Apr 19 11:44
World Book Day! (1 images)
Luca Y2 really enjoyed dressing up for 'World Book' Day, he came as the BFG and was great at 'flossing' in his costume!
Created: 13 Mar 19 10:22 | Last modified: 13 Mar 19 10:23
Pancakes! (2 images)
Logan Y2 enjoyed flipping a pancake and enjoyed eating then after with lemon & sugar. He also enjoyed playing with our small world creatures.
Created: 13 Mar 19 10:19 | Last modified: 13 Mar 19 10:21
Starlight - December 2018 (2 images)
'The Starlight staff & children enjoy this time of year, especially Quinton from Y1. Our theme for this term is PEACE and all the children have created our wall display.
Created: 3 Dec 18 11:41 | Last modified: 3 Dec 18 11:42
Starlight Fun! (1 images)
This summer Starlight Room have been celebrating the children being 'FAB' P.A.W's kindly donated the FAB ice lollies to reward each child for their outstanding achievements. Crystal, Keri & Leah Y2 enjoyed the treat!
Created: 12 Jul 18 09:57 | Last modified: 12 Jul 18 09:57


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Every investment involves some level of risk and annuities are no different. An annuity is an insurance contract used to provide a source of income during your retirement. Depending on how your contract is structured, you might fund it with a one-time lump sum or with scheduled contributions over time.
Fixed versus Variable
If you are concerned about risk when deciding whether an annuity is the right investment vehicle for you, a fixed annuity can be designed in such a way that risk is minimized by sticking with conservative, fixed interest rate returns. Going with a variable annuity where your contributions are invested in bond or equity markets increases the risk that your portfolio will suffer losses. Remember, when it comes to investing the higher the return, the greater the risk.
Consider the risks associated with the following types of annuities:
- Stock Fund Annuities. These annuities might be invested on stock mutual funds that are professionally managed. As a variable annuity, these funds can generate large gains or losses depending on market performance.
- Fixed Income Annuities. A fixed income annuity insulates the investor from market volatility. This annuity has a guaranteed interest rate and is designed to grow predictably. The risk that exists with this type of annuity is that there is always the possibility that it will not keep pace with inflation.
The Risk of Insolvency
Since annuities aren't FDIC-insured, if the insurance company that has issued the annuity becomes insolvent, there is a possibility of loss. States usually provide funds to prevent annuity losses. However, if the amount invested in an annuity exceeds the state's coverage amount a loss could occur if the insurer goes bankrupt.
The bottom line? You don't want to risk your retirement savings, and you do want a reliable, steady source of retirement income. Contact us for a consultation, where we can weigh the potential risks and returns of various options and come up with a solution tailored to your retirement goals.


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Andre Iguodala's two years with the Arizona Wildcats in 2002-03 and 2003-04 are almost a blur because of his sudden departure to the NBA, a move by players fans in Tucson have become accustomed to in recent years.
Now 13 years into his NBA career, Iguodala continues to be impressive in his overall game, including his shooting, which was not yet fully developed when he left Lute Olson and the Arizona Wildcats following his sophomore season.
The two-time NBA champion and Finals MVP in 2015, is one of the most accomplished former Wildcats to play in the NBA.
If your memory of Iguodala's feats with the Arizona Wildcats has faded away because of the 13 years since he played for Olson, the following ranking will make you recall his value. He is the only Arizona player with three triple-doubles to his credit (all in one season, 2003-04).
In that same season, Iguodala was the first Arizona player to lead the team in rebounds, assists and steals in the same year.
Some of his better games with Arizona Wildcats did not make the list like the time he scored a career-high 25 points with eight rebounds at California (Feb. 5, 2004) or when he had a 10-point, 15-rebound game at Washington State (Jan. 29, 2004).
Against Washington State at McKale Center on Feb. 28, 2004
Andre Iguodala, in only his sophomore season in 2003-04, became one of the best players in the nation while starring for the Arizona Wildcats. He grabbed a career-high (and Arizona season-high) 16 rebounds to go with 12 points and three assists in the 72-60 win over the Cougars at McKale Center.
"We needed a win bad," Iguodala was quoted as saying by the Associated Press as the Wildcats improved to 18-8. "Also, I really need to attack at all times instead of being passive. I was just trying to attack today."
The Wildcats snapped a two-game losing streak with the win. Iguodala's hustle set the tone for the grind-it-out victory against the Cougars.
Against Liberty at McKale Center on Dec. 28, 2003
Iguodala achieved his second triple-double of the season with 13 points, 11 rebounds and 11 assists in a 107-91 win over Liberty at McKale Center on Dec. 28 as part of the Fiesta Bowl Classic.
With 6:34 left and Arizona ahead 96-67, Iguodala turned into a point guard, finding freshman Mustafa Shakur for a layup. His triple-double was complete.
"It's not very often that you have a chance at a triple-double, and that's why we left him in a little longer than we probably needed to," Lute Olson told Steve Rivera in a Tucson Citizen report.
Iguodala told Rivera playing the point took him back to his boyhood days.
"It was like high school, because I was a point guard (then)," the Springfield, Ill., native said. "I just called the play and found the open man."
Iguodala joined Loren Woods as the only Arizona player to have two triple-doubles at that time.
Against Louisiana-Lafayette at McKale Center on Dec. 30, 2003
Only two nights after the triple-double against Liberty, Iguodala thrilled the McKale Center crowd with a career-high 23 points (his first career 20-point game) that included the game-winning three-pointer with nine seconds remaining. He also had nine rebounds to go with five assists in the 72-69 win over the Ragin' Cajuns in the title game of the Fiesta Bowl Classic.
Louisiana-Lafayette coach Jessie Evans, an Arizona assistant for nine years under Lute Olson, told the Tucson Citizen: "We were right there."
Iguodala put the Wildcats on top with his 20-foot jumper with only two seconds left on the shot clock and nine seconds overall. Arizona point guard Mustafa Shakur passed to Iguodala in the corner for the shot although he was the third option behind sharpshooters Salim Stoudamire and Chris Rodgers.
"That's the first time it ever worked like that," Iguodala told the Citizen's Steve Rivera about being the viable option for the pressure-filled shot.
Against UCLA at McKale Center on Feb. 14, 2004
In what was dubbed the "Valentine's Day Massacre" by the Arizona Daily Wildcat, Iguodala posted his Arizona-record third career triple-double with 14 points (behind 9-of-10 shooting from the free-throw line), 11 rebounds and 10 assists to go with five steals in the 107-83 rout of the rival Bruins.
Iguodala's performance was magnificent but it was a subplot to Salim Stoudamire's career-high 34 points behind 13-of-17 shooting from the floor, including 7-of-9 from three-point range.
"He's just like Luke Walton was last year for us, except more athletic," Stoudamire told the Wildcat about Iguodala, who now plays for Walton (a Golden State assistant).
Iguodala had more offensive rebounds (five) than the Bruins, who managed to grab only four. He complimented Stoudamire and others for allowing him to gather 10 assists.
"I thank my teammates," Iguodala told the Wildcat. "If they don't shoot the ball well, I wouldn't be able to find them. I'm just in the right place at the right time."
Against Texas at Madison Square Garden in New York City on Dec. 9, 2003
Iguodala had a better performance than nearby Broadway posting his first career triple-double — the seventh in Arizona Wildcats history — with 13 points, 13 rebounds and a career-high 10 assists in the 91-83 victory over Texas in the Jimmy V Classic at Madison Square Garden.
Iguodala's triple-double and Hassan Adams' career-high 30 points with 10 rebounds enabled Arizona to win at Madison Square Garden for the ninth consecutive time and increase the Wildcats' winning streak over the Longhorns to eight games.
"We had a chance to break it open all game," Iguodala told the Associated Press. "Once we clamped down on defense, it opened things up and we got onthe boards hard and we kept running and tired them down.
"Our chemistry is coming together, and I'm having a good time with it."
ALLSPORTSTUCSON.com publisher, writer and editor Javier Morales is a former Arizona Press Club award winner. He is a former Arizona Daily Star beat reporter for the Arizona basketball team, including when the Wildcats won the 1996-97 NCAA title. He has also written articles for CollegeAD.com, Bleacher Report, Lindy's Sports, TucsonCitizen.com, The Arizona Republic, Sporting News and Baseball America, among many other publications. He has also authored the book "The Highest Form of Living", which is available at Amazon.


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A CRACK DOWN on anti-social behaviour is being launched by police around Knotty Ash from Monday. Read
A CRACK DOWN on anti-social behaviour is being launched by police around Knotty Ash from Monday. Read
Another piece of poor editorial. The headline says Knotty Ash and the body says West Derby, which it is. I can only presume that the people responsible for the anti social behavior stay in on a Wednesday night as I've never seen anyone hanging around when I'm walking to the quiz in the Hare & Hounds.
Last edited by JMLE; 03-16-2009 at 05:50 AM.
Same here, we walk across Dovecot Park, down the cinder path and along Leyfield Rd on a Thursday evening and hardly see a soul, whereas there have been loads of problems with yobbish behaviour in Dalemeadow at the back of Ken Dodd's.
I used to live in Gordon Drive - anyone with any news/thoughts on that road?
For daily updates, to support us further or to join in the conversation: Follow us on Twitter @YOLiverpool / Like our Facebook Page: @yoliverpoolpics / Join the Facebook Group: YO! Liverpool Pictures


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Find Trade Association expertise in Dominica
The Dominica Association of Industry & Commerce is Dominica's llargest private sector association, promoting trade, commerce and industry. Examples of other trade Associations include national entities such as the Dominica Hotel and Tourism Association, whose mission is to promote tourism and related services as a critical sector in Dominica's economic development and to support members' efforts to improve the standards of their products and the quality of their services; and the Dominica Coalition of Service Industries, which is a member of the regional Caribbean Coalition of Service Industries.
|Trade Associations and Chambers of Commerce organisations in Dominica
|Chamber of Commerce
|Dominica Association of Industry and Commerce


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RSVP AstroCentre
Find your compatibility
Western Star Signs
Capricorn's more emotionally detached, reserved, down-to-earth and somewhat cynical or sceptical attitude contrasts with Leo's warm enthusiasm and basically cheerful temperament. In your personal style and tastes, also, this difference is very apparent: Capricorn prefers the classics, simple elegance, and either a very conservative, traditional style or an austere less-is-more, keep-it-simple style.
Leo has a generous, lavish hand and loves rich colour, warmth, and brilliance that borders on gaudiness. Sometimes, this translates into emotional terms also. Capricorn is more careful, cooler, less inclined to gamble, and wants a sure thing.
Leo is more open and expressive and warm, and needs an abundance of appreciation and affection - more than Capricorn is inclined to give sometimes. One thing you do have in common: you both take your commitments to heart, and you prize fidelity and loyalty.
Essentially, Capricorn is cautious, steadfast and reserved. Even as a child, Capricorn's personality was probably mature for the years. With any luck Capricorn's life will get better and responsibilities will become more enjoyable over time. Capricorn can only fail by giving up. Never, never, never, never, never give up. Capricorn, you were made for management and leadership. Capricorn's ambitions are only limited by your self-esteem. Planning and work will pay off. Be sure to ask for a fair price for your efforts.
In the relationship between Leo and Capricorn adjustment is key. You both need to give more than you get. This association requires extra sensitivity. At first, you may be somewhat irritated with each other. In time, with work, the very thing that caused the irritation may lead to personal fulfillment. You can't force growth in this alliance - go along with the changes. To beat the odds, change your routines.
Search for other Capricorn singles »
Chinese Star Signs
The Tiger and the Dog pairing is usually very strong and rewarding. They share many of the same qualities and their differences compliment one another. As lovers each will give the other the space they need to ensure their bond is mutually fulfilling. Their overall compatibility rating is 90%.
Dogs are loyal, truthful and live by their own uncompromising code of ethics. While very trustworthy, they do find it difficult to trust others. Dogs are faithful friends and exceptional listeners. They are the caped warriors of the Chinese Zodiac in that they will fight injustice and side with the underdog anytime, anyplace.
Dogs can be very rigid in their thinking and behavior. They also tend to be moody and need time alone to sulk and revitalize. Dogs are slow to trust, but with time and evidence that someone is trustworthy they will warm up to them.
Dogs need physical activity to be happy. They will champion any cause they deem worthy.
In the pursuit of love, Dogs may be their own worst enemy. They can become so anxious from engaging in the mating ritual that they create too much stress in their potential partners for their dance of love to be successful.
Note that Chinese star signs are determined by your exact date of birth, and not just your birth year. For more information, read about the Chinese Zodiac »


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As U.S. soybean prices trade near their highest level in four years, the choice as to when to sell becomes more complicated.
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text:
Your skill will accomplish
what the force of many cannot
Re: Syntax Perl Version support $c = () = $a =~ /\./gby Anonymous Monk
|on Jul 17, 2018 at 19:42 UTC ( #1218688=note: print w/replies, xml )
|Need Help??
And wouldn't it be the perfect thing to put in a descriptively-named one line subroutine that hides the Perl-voodoo in only one place, and tells everyone else exactly what it's supposed to do? Mmmmm....? Perl has lots of ways to write something such that you don't know at a glance what it's supposed to do, and it doesn't actually do what you intended for it to do or thought that it did, either. Sure would be nice to be able to fix any problems in one place.
In Section Seekers of Perl Wisdom


text:
Amendment C040
Mildura Planning Scheme
Amendment status
Amendment last updated
Environmental Effects Statement (EES)
Planning authority contact details
Minister for Planning
Level 16 8 Nicholson Street East Melbourne VIC 3002 Australia
Tel: (03) 8683 0964
Please Note: Proposal description below describes the amendment. To verify content of the final approved amendment see the Explanatory Report.
Replaces the existing Schedules to Clauses 36.03, 52.17 and 61.01-61.04 (inclusive) to facilitate preliminary works in the form of hydro-geological, environmental and cultural heritage investigations for the Long Term Containment Facility for industrial wastes.


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Full Day
The SACRED VALLEY TOUR explores the stunning Sacred Valley of the Incas, which was of great significance in Inca Culture.
The Sacred Valley of the Incas has a milder climate and lower elevation than Cusco and visits a succession of picturesque villages, agricultural terraces, and archaeological sites. This region is exceptionally beautiful so be ready with your camera. This tour is the classic/traditional Sacred Valley tour where you will see the main sites in one very full day. In addition to the sites we visit on this tour there are other sites of interest in the Sacred Valley that can be visited separately (Maras, Moray & Salineras, Tipon, Pikillacta, & Andahuaylillas). We recommend an overnight in the Sacred Valley in order to truly appreciate and soak up the relaxed atmosphere here. This tour can also be added on to the Machu Picchu Train tour or any Trek for the complete Cusco experience!
Minimum passengers necessary for tour departure: 2 people (small group, 1 person or private/custom treks possible with extra fee). Maximum trekkers per group: 10 people (special, private party groups can exceed maximum).
The Nitty Gritty Tour Details
Adventure Rating
easy, gentle walk
Solitude Rating
Touristy, but a must not miss tour!
When to Go
Prices USD
Itinerary for Sacred Valley Tour
You will be collected from your hotel or the Plaza Regocijo (your choice) in Cusco at 8:30am and driven via private transport to 4 local communities in the Sacred Valley. From Cusco it is just over one hour to our first stop, the local community called Pisac. In Pisac you will be guided through the ruins above the town and have a chance to explore the incredible Pisac Market (biggest on Tuesdays, Thursdays and Sundays). After Pisac you will be driven for one more hour to Urubamba where you will have time for lunch at a restaurant of your choosing. Following lunch we depart again for 25 minutes to Ollantaytambo to explore the ruins there. We drive for another hour and twenty minutes to reach Chincheros where we will see the local colonial church and a little market. After we are finished exploring we return to Cusco via our private transport (one hour). You will be returned to your Cusco hotel at approximately 6:00pm.
- Meeting point: your hotel or the Plaza Regocijo
- Tour departure: 8:30am
- Tour finish time: 6:00pm
- Daily departures with 2+ people
- Price in USD:
- 100/person for 6-10 guests
- 110/person for 3-5 guests
- 125/person for 2 guests
- solo guest, custom tours, large private group tour prices upon request
Itinerary for Tour when combined with Machu Picchu Train tour
You will be collected from your hotel in Cusco at 8:00am and driven via private transport to 3 local communities in the Sacred Valley. From Cusco it is just over one hour to our first stop, the local community called Pisac. In Pisac you will be guided through the ruins above the town and have a chance to explore the incredible Pisac Market (biggest on Tuesdays, Thursdays and Sundays). After Pisac you will be driven for one more hour to Urubamba where you will have time for lunch in a restaurant of your choosing. After lunch we depart again for 25 minutes to Ollantaytambo to explore the ruins here. After the tour you will be taken to the Ollantaytambo train station where you will take the train to Aguas Calientes. The train ride is approximately 1 hour 45 minutes. Once in Aguas Calientes you will be taken to a hotel for your overnight stay. Please see the Machu Picchu Train Tour listed under "Tours" for the remainder of the tour description in Machu Picchu.
- Meeting point: your hotel or the Plaza Regocijo
- Tour departure: 8:00am
- Tour finish time: 2:00pm then on to Aguas Calientes for the Machu Picchu portion of the tour
- Daily departures with 2+ people
- Price: please see the Machu Picchu Train Tour for prices
Included in Full Day Sacred Valley Tour
- Pick-up from your hotel or Plaza Regocijo (your choice) if you're already out and about.
- Private Transport to Pisac, Urubamba, Ollantaytambo, Chincheros and back to Cusco
- Professional English-speaking guide who will provide the guided tour
- 1 Day Tourist Ticket for sites included in this tour
- Bottle of water and snacks
Included in Sacred Valley Tour when combined with Machu Picchu Train Tour
- Pick-up from your hotel or Plaza Regocijo (your choice) if you're already out and about.
- Private Transport to Pisac, Urubamba, Ollantaytambo
- Professional English-speaking guide who will provide the guided tour
- 1 Day Tourist Ticket for sites included in this tour
- Bottle of water and snacks
- See Machu Picchu Train Tour for full inclusion details
Dietary needs: Can cater to any dietary need, just let us know!
- Souvenirs
- Tips for your guide
- Travel interruption & medical insurance
- Lunch in Urubamba (we find that people prefer to choose their own restaurant as there are many choices and people have different preferences)
- pick up/drop off from non-Cusco based hotels (incurs an extra fee)
The Cusco City tourist ticket included on this tour is for one day and includes the sites seen on this tour only. If you plan to stay in Cusco for several days and/or plan to do several tours you can upgrade to the 10 day tourist ticket when you book your tour. The 10 day tourist ticket includes the following sites:
- Sacsayhuaman
- Q'enko
- Puca Pucara
- Tambomachay
- Pisac Ruins
- Ollantaytambo Ruins
- Chinchero
- Tipon
- Pikillacta
- Moray
- Cusco Center of Native Art (Centro Qosqo de Arte Nativo)
- Inca Pachacuteq Monument/Museum (Monumento Pachacuteq)
- Qoricancha Museum (Museo de Sitio de Qoricancha)
- Contemporary art museum (Museo Municipal de Arte Contemporaneo)
- Popular Art Museum (Museo de Arte Popular)
- Regional History Museum (Museo Historico Regional)
Note that this ticket does not include:
- Qoricancha aka the Santo Domingo Complex (10 soles entry fee)
- Main Cathedral (25 soles entry fee)
- Maras (10 soles entry fee)
- Andahuaylillas (10 soles entry fee)
- Salineras aka Salt Mines (10 soles entry fee)
Typically people visit these sites in specific groupings, for example:
- Cusco Four Ruins: Sacsayhuaman, Q'enko, Puca Pucara, & Tambomachay
- Sacred Valley Tour: Pisac, Chinchero, & Ollantaytambo (plus Urubamba which does not require an entry fee)
- Maras, Moray & Salineras Tour
- Tipon, Pikillacta & Andahuaylillas Tour
- Cusco City Tour: San Pedro Market, main plaza, some of the above museums, and our city tour also includes Qoricancha and the Main Cathedral.
- Daypack
- Sunscreen
- Hat and sunglasses
- Camera
- ISIC card if you are a student
- Rain gear and warm jacket in the event of inclement weather
- Good shoes for walking over pavement and dirt paths
- Money for souvenirs, tipping, extra snacks (Note: foreign money must be in perfect condition with no rips, tears, or marks, as no one in Peru will accept less than pristine bills)
Cusco often experiences all seasons in one day so it is a good idea to take a warm hat and gloves as well as a sun hat when you leave in the morning in order to be prepared for all weather.
Yes, we do cater to any dietary restriction. We have had many people join our trips who are vegan, vegetarian, gluten free, dairy free, and have various other intolerances and/or allergies. Just inform us well in advance of your specific needs!
Year-round, though the best weather is usually seen between March/April to November (or dry season). This tour is rated as easy to moderate as it involves gentle walking at each site. This is a great acclimatizing day tour as it is gentle walking at a lower altitude than Cusco. Please note if the weather is very poor the trail could be dangerous and we may have to cancel the trip and may be able to substitute another day hike or day tour instead, depending on the circumstances.
Deposit: The entire day hike cost will be charged to your card when you book the trip. 50% of this is non-refundable.
Payment of Balance: The balance of the tour is due 30 days (changing to 60 days prior starting 2020) prior to departure and will be auto-debited via the booking software system on that date. If you wish to pay early, or use a different card to the one you have on file, you may do so by clicking on the reservation number in your confirmation email and entering the pin that was provided to you in the original confirmation email. If you wish to make other arrangements (e.g. pay cash in Cusco), please contact us. Please note if you book your trip within 30 days of departure, the balance of the trek will be auto-debited the next day. If you do not wish this to happen please contact us.
Passport: For this trek we do NOT need a photo of your passport bio page. However, as this involves international travel, please note that each traveler is responsible for knowing the re-entry rules for their country of residence/citizenship. Some countries require 6 months of passport validity beyond the final date of travel. Please ensure that your passport is up to date and meets your country and residency requirements.
Visa's: Most countries are allowed to obtain a visa upon entry at immigration. Very few countries require a visa to be granted in advance. Please note that each traveler is responsible for finding out and obtaining a visa prior to entry if required. Please also note that tourist visas are for 90 days or less (typically) and you must show proof of return travel.
Please review our booking terms carefully.
- The minimum number of trekkers required for departure is 6 for the price quoted online. If the minimum is not met within 2 weeks of departure, Killa Expeditions reserves the right to offer the 1-2 paid trekkers the option of 1) paying the difference to take a private trek, 2) transferring their payment to another trek with more trekkers booked, or 3) cancel the trek and provide a full refund. Please contact us with questions.
- At the time of booking the entire day hike cost is charged. This is required to secure your spot on the tour and 50% is non-refundable. The balance of the trip (if any) is due within 30 days of departure (or 60 days as of 2020 trips)
- Cancellations: Initial deposit is non-refundable. You may cancel your booking by notifying Killa Expeditions or Agent used and the applicable cancellation fees shall be determined based on when the request is received by Killa Expeditions or Agent. (a) Cancellation received 60 days or more before departure of the first Product to depart in relevant booking: 60% of the Product total shall be refunded to you (Inca Trail excepted where 25% of the Inca Trail product total shall be refunded to you). (b) Cancellation received 59-30 days before departure of first Product to depart in relevant booking: an amount equal to 25% of the total Product shall be refunded to you. (Inca Trail excepted where no refund is payable). (c) Cancellation less than 30 days before departure of first Product to depart in relevant booking: no refund shall be payable to you.
- Travel Medical Insurance: is required to depart on any trek (including emergency evacuation coverage and high altitude hiking). We also suggest travel interruption insurance in the event of inclement weather or other unforeseen circumstances that may arise. Killa Expeditions is not responsible for losses incurred due to any travel interruption (ex: weather/natural phenomena, missed/delayed/canceled flight, acts of war/terrorism, strikes, etc.), passport, visa, family emergency, or illness/medical issues.
- For Full Terms and Conditions please see the policy linked at the bottom of our website in the footer. It is also available to read during the checkout process. https://killaexpeditions.com/terms-conditions-peru/
Helping Local Children or Andean People (Optional) Along certain treks we may encounter some local children and Andean people. If you wish to lend a helping hand you may bring some clothes, toys, books and school equipment (used or new), toiletries and other essentials, and new/sealed medication for a variety of ailments. You will be rewarded with their gratitude and beautiful smiles. Please do not give candy or sweets as they do not have access to dental/medical care and tooth decay can lead to serious illness.
For those who wish to help but take a trek that does not pass local people or villages you can leave your donated items with a Killa Expeditions representative and we will distribute them to one of the local communities that we support. You can also set up a day to visit a local community to donate your items personally! There are a variety of other ways in which to lend a helping hand to local communities (charity events, building schools, and much more). We support several local communities so if interested please get in touch!
ETHICAL, SUSTAINABLE, ECO-FRIENDLY Our mission is to provide exceptional treks, tours, and adventure trips with a strong commitment to environmentally responsible, sustainable, ethical, and socially conscious travel. During our trips, we make every effort to minimize negative impacts and maximize the benefits to the local people and natural environments we visit. We pay fair, livable wages, ensuring we hire and maintain the absolute best guides and support staff. We are committed to international sustainable tourism guidelines and have developed ongoing community projects and charity events supporting 4+ local Andean communities.
EXCELLENCE We pride ourselves on providing 5 star service before, during, and after your trip. Killa Expeditions is dedicated to excellent customer service and adventure experiences. We have been awarded the 2017, 2018 & 2019 Trip Advisor Certificate of Excellence!
QUALITY When trekking through rugged mountain terrain, at high altitudes, with unpredictable weather, it is essential to have the best equipment available. We provide Mountain Hardwear 4 season tents (3 season for Inca Trail due to warmer weather), extra thick mattress pads, dry bags for your overnight gear, and more, to ensure a safe and pleasant journey.
NO HIDDEN COSTS Our treks and tours are truly 5 star and all inclusive. We do not charge extra to "upgrade" as we offer the best option included in the price already. There are no hidden meal costs, we are transparent about all inclusions, and best of all no booking fees!
SMALL GROUPS Our groups average about 8 guests per departure, and are typically a mix of solo travellers, friends travelling together, and couples, all of varying ages, backgrounds and nationalities. Come prepared to make lots of new best friends. If you book a custom/private large group we provide 1 guide per 8 travelers, ensuring a small group feel and specialized attention.
GOURMET Only the best, quality ingredients are selected from local farmers. Our chefs prepare a specially designed menu to maximize energy and facilitate acclimatization. And the dishes, a mix of traditional Peruvian cuisine and contemporary cuisines, are delicious too! And yes, we cater to any dietary need.
PERSONALIZED We can customize any trek or tour to suit your travel, fitness, budget, and time preferences. Got a corporate or work shindig, charity group, or other major event you'd like to book a trek or tour for? Get in touch, we can arrange everything for you!
LEAVE NO TRACE Our trips leave behind nothing but smiles and footprints, as it should be.
REDUCE REUSE RECYCLE We love our planet, which is why we reduce, reuse and recycle. Our gear is reusable (no paper or plastic plates/cups/utensils), we buy local goods that do not come in paper/plastic wrapping, and we recycle everything we can. This is not the norm in Peru but we hope to help it become the norm one day soon!
PASSIONATE All of our employees are passionate about what they do. Who wouldn't be with majestic mountains and never-ending vistas as your office! We are proud to offer our guides and staff the highest wages.
WE GIVE BACK We buy locally produced food, hire native tour guides, and book locally owned hotels and restaurants whenever possible. We hold numerous charity events throughout the year in various traditional Andean communities. Events often involve distributing food, drinks, daily essentials (such as toothpaste, toothbrushes, soap, and more), toys for the children, shoes and clothes donated by many of our wonderful guests, and we are currently raising funds to finish building a school in the Willoc Community. Ask us about how you can help!
For further information about us please see the following links:
Equipment: learn about why we provide the best! http://www.killaexpeditions.com/our-equipment/
Our Team: meet some of our amazing guides! http://www.killaexpeditions.com/our-team/
Reviews – find us on Trip Advisor! Killa Expeditions Trip Advisor Page (Awarded 2017, 2018 & 2019 Certificate of Excellence)
Subscribe to our newsletter to stay up with the latest from our team
Don't Be Shy
If we didn't answer all of your questions, feel free to drop us a line anytime.


text:
Processor Shortage
Don't delay your hardware replacement
Since late last year, Intel has been warning about a processor shortage for new workstation orders. Those warnings are now fact and we do not see a change in processor availability in the near future. The end of life of Windows 7 has increased the demand for workstations considerably and there simply is not enough processors to fulfill the need. We are seeing orders take 4 weeks or longer to process. AMD processors are in a similar shortage as purchasers are looking for alternatives.
When XP was its last year of support, a similar situation took place. Workstations had aged to a point where purchasing new was the best option but acquiring hardware in a timely manner became difficult . Businesses who waited until late in the year could not acquire hardware until 3 months after the New Year. Typically, this was an acceptable business risk for those that waited, but for others they paid a premium to acquire hardware to become compliant. If your budget has you upgrading workstations this year, we would recommend doing so with plenty of time before the end of the year. If you would like to start your hardware replacement plan now, please contact us at 320-235-6425 or email us at firstname.lastname@example.com to start that process.


text:
By Terry P Kenakin
This profitable advisor assists scientists proficient in molecular biology and similar fields who now want to know the fundamental theories, ideas and functional functions of pharmacology. This most modern variation keeps the culture of higher getting ready researchers within the fundamentals of pharmacology. With increased hands-on workouts and the addition of Pharmacokinetics insurance, new human curiosity fabric together with historic proof in pharmacology and a brand new part on therapeutics that would aid readers establish with ailments and drug treatments.
The perfect publication for researchers in drug discovery who've obvious their function shift from ''individual'' to ''team player'' the place that workforce comprises chemists, biologists, and others with powerful, yet diverse, technology backgrounds who needs to now interact towards their universal pharmacology target.
At GlaxoSmithKline, a prescribed drugs world-leader, Terry Kenakin on a regular basis teaches a path for his or her learn scientists and has drawn on his adventure to create a pharmacology primer.
*New - most up-to-date assurance of the chemistry of substances together with accelerated insurance of the pharmacokinetic dialogue of druglike houses -- raises reader figuring out of worthy ADME (Absorption, Distribution, Metabolism, and Excretion) homes and raises the speed of drug approval and popularity.
*Context - special discussions on quite a few drug discovery groups and the function of the chemist on these groups -- Promotes the knowledge of those increasing roles and obligations and the way to maximise the potent contributions of every matrix staff member.
*Real-world studying - There are hands-on workouts, with broad solutions, using genuine info on constitution job relationships; usage of pharmacological ideas to make common statements approximately how adjustments in constitution result in adjustments in drug job. + fingers on workouts with vast solutions on Pharmacokinetics -- Stengthens functional software and knowing of center techniques and principles.
*Study sections are equipped with ASPET (American Society for Pharmacology and Experimental Therapeutics)and different foreign enterprises -- guarantees that studying follows expert criteria.
Read or Download A Pharmacology Primer. Theory, Applications, and Methods PDF
Best pharmacology books
Brain Disabling Treatments in Psychiatry: Drugs, Electroshock, and the Psychopharmaceutical Complex
Well known psychologist Peter Breggin records how psychiatric medicinal drugs and electroshock disable the mind. He provides the newest clinical info on strength mind disorder and unsafe behavioral abnormalities produced through the main regular medications together with Prozac, Xanax, Halcion, Ritalin, and lithium.
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In Viral Membrane Proteins: constitution, functionality, and Drug layout, Wolfgang Fischer summarizes the present structural and practical wisdom of membrane proteins encoded via viruses. furthermore, individuals to the ebook tackle questions about proteins as power drug goals. the diversity of data lined comprises sign proteins, ion channels, and fusion proteins.
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It's been nearly twenty years because the discovery by way of Kohler and Milstein of the know-how to supply monoclonal antibodies (MAbs), a discovery that promised progressive adjustments in examine, scientific analysis and human treatment. From cutting-edge point of view, it truly is reasonable to finish that this promise has been learned in parts of the 3.
Therapeutic Protein Drug Products. Practical Approaches to Formulation in the Laboratory, Manufacturing, and the Clinic
Healing protein drug items offers a entire review of healing protein drug items, with an emphasis on formula starting within the laboratory, through production and management within the sanatorium. a listing of many advertisement healing drug items are defined and contain the product identify, dosages, lively focus, buffer, excipients, Ph, box variety and direction of management.
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Extra resources for A Pharmacology Primer. Theory, Applications, and Methods
Example text
Response 120 100 80 60 40 20 0 5 10 % Receptor activation 0 A Smooth Muscle Contraction vs Receptor Stimulation 120 % max. 19 Potentiation and modulation of response through control of cellular processes. (A) Potentiation of inotropic response to isoproterenol in guinea pig papillary muscle by the phosphodiesterase inhibitor isobutylmethylxanthine (IBMX). Ordinates: percent of maximal response to isoproterenol. Abscissa: percent receptor occupancy by isoproterenol (log scale). Responses shown in absence (open circles) and presence (filled circles) of IBMX.
As put by W. D. M Paton [17]: The guinea pig longitudinal muscle is a great gift to the pharmacologist. It has low spontaneous activity; nicely graded responses (not too many tight junctions); is highly sensitive to a very wide range of stimulants; is tough, if properly handled, and capable of hours of reproducible behavior. — W. D. M. Paton (1986) All of drug discovery relied upon such functional assays until introduction of binding techniques. , the experiments were labor intensive). Therefore, the numbers of compounds that could be tested for potential activity were limited by the assay format.
For example, cells contain phosphodiesterase enzymes to degrade cyclic AMP to provide a fine control of stimulus strength and duration. Inhibition of phosphodiesterase therefore can remove this control and increase cellular levels of cyclic AMP. 19A shows the effect of phosphodiesterase inhibition on the inotropic response of guinea pig papillary muscle. 2% required receptor stimulation after inhibition of phosphodiesterase degradation of intracellular cyclic AMP. This technique can be used to modulate 400 300 200 100 300 200 200 msec C 0 100 200 msec 70 60 % max.


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Pinnacle Advisory Group's Chief Investment Officer Ken Solow looks at the firm's performance in bear and bull markets. The keynote presentation from our February 25 Inside the Investment Committee event.
Author: Ken Solowhttp://pagmain.wpengine.com
Kenneth R. Solow, CFP®, ChFC is a founding partner and serves as the Investment Committee Chair of Pinnacle Advisory Group, Inc. As a founding Partner, he was instrumental in creating the tactical asset allocation strategy currently used by Pinnacle to manage $2.2 billion in assets. Solow is nationally known for his views on active portfolio management, and his 2009 book, Buy and Hold is Dead (Again): The Case for Active Portfolio Management in Dangerous Markets, is considered the definitive work on Tactical Asset Allocation. Solow appears regularly at events sponsored by the Financial Planning Association, National Association of Financial Planners, the Investment Management Consultants Association, and the AICPA, and has been published in The Journal of Financial Planning, Smart Money, Financial Planning Magazine, The Baltimore Sun, the Globe & Mail, and the Wall Street Journal.


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John Hurrell – 31 October, 2019
With a convex mirror conspicuous over an elegant (but dysfunctional) Edwardian basin on a pristine pale blue wall, and copious sheets of self-absorbed pencilled (partially erased) writing scattered on the floor, the installation is obviously preoccupied with selfhood and emotional stability. The fish-eye mirror hints at a paranoid Escheresque ambiance.
Severine Costa, Xander Dixon
12 October - 9 November 2019
The second tranche of this 'new artists' show features Severine Costa and Xander Dixon, each artist (like before) being given plenty of room to demonstrate their sculptural or planar concerns.
Costa's installation (And the Sky Slowly Seeping Through) seems like a homage to Smokey Robinson, a satire sending up the plethora of celebrities reciting traumatic personal tales of clinical depression. It conceptually merges daily psychic interiorities and climatic exteriorities seamlessly together.
Her installation dwells on the liquid residue, the daily measuring and accumulation of water, its documentation, transitions and recycling-perhaps from weeping; perhaps from condensation on Artspace Aotearoa's glass doors—overlaid with meteorological predictions and percentages of pollutants. It dwells on procedural formalities, the labelling, tabling, filling and emptying of small bottles, the storing of diaristic information—and as a metaphorical parallel, the presence of two types of sink: one functional, linked to an aquarium serving as a kind of sump; the other not.
With a convex mirror conspicuous over an elegant (but dysfunctional) Edwardian basin on a pristine pale blue wall, and copious sheets of self-absorbed pencilled (partially erased) writing scattered on the floor, the installation is obviously preoccupied with selfhood and emotional stability. The fish-eye mirror hints at a paranoid but Escheresque ambiance. There is a compulsive obsessiveness involved too, as in the constant statistic making, or the rubbing out of sections of pencilled text, though that might allude to the effects of dripped ocular water.
Xander Dixon's suite of photographs and installation (Sharing Directions) reference mana whenua rights (and Pākehā assumptions) in Te Waipounamu, particularly the Tuao Wharepapa (Mt. Arthur) plateau near Kahurangi in Nelson. At first glance one could easily mistake Dixon's contribution for an understated project by Pauline Rhodes.
In this show his imagery is less poetically evocative than Severine Costa's, being very focussed politically (and specific geographically)—particularly with its references to colonial surveying pegs and stakes, and to the European perception of an 'empty' landscape. The red tubes in the gallery seem to be being regularly shifted around, tending to drift towards the eastern side of the building and avoiding the western wall.
To me, Dixon's work seems too simple, being unargued (merely stated) in its emphasis on the movement and transience of landownership, and too declarative in its singularity of presumptions. It makes no effort to draw the viewer in. (What sort of viewer you might ask?) No layered or worked-on complexity is forthcoming to entice prolonged interest. No resonating tropes to make visitors linger.
I have no beef with the politics of the piece—that's easy to grasp—only the lack of 'artness' in the art, the paucity of structured ideational weight.
John Hurrell


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|Jun 14, 2008, 9:42 AM
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Join Date: Aug 2005
Location: Arlington, Texas USA
Posts: 3,585
......it ain't MLB (see Greg's Rangers post) but the ticket cost was only 4$ (2 games), the concession stand had really good hamburgers for 3$ and I was back on the field, what FUN.
This was my first time out to use the 70-300ZD....I actually left the 50-200 behind. Though the files are not quite the same IQ as I normally get with the 50-200 by the end of the day I became comfortable using the lens, having gotten over the influence of 600mm equiv and just started using it to get the best composition at the time.
The light here was at exact midday, clear sky @ 97F temp, IT WAS HARSH but using shutter priority with auto WB, auto ISO some of the pics are ok.
I really like this lens, it is exactly like everyone here has proclaimed, I just have to learn to use it.
......the obligatory picture of my grandson
AND a couple files to share of our other 16 year old players............
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|Jun 14, 2008, 10:11 AM
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Join Date: Dec 2006
Location: Cape Cod, Massachusetts
Posts: 5,191
Hi Bob,
Nice shots indeed!
As for the photos of the grandson, Your sports action shots of your grandson are inspirational to me-can't have too many of those. My grandson is 6 and is currently playing T-Ball andI can't wait for him tomature to play on a more formal level. As it is, we're going to go to one of his games on Monday. I'm also bringing the 70-300mm with me. This will be my first attempt at shooting a sports event-albeit, maybe not moving that fast:-).
Wish you good luck with the 70-300mm.
|Jun 14, 2008, 11:23 AM
Senior Member
Join Date: Aug 2005
Location: Arlington, Texas USA
Posts: 3,585
Thanks Zig.... they only grow up 1-time so take a lot of photos. It has been some time since T-ball for me but I do have one more grandson coming along (3 yrs) so maybe again someday.
This team is made up of 16's, they each started varsity for their high school team this past year. There are 14 players on the team and each plays several positions so it makes for a fun summer. My grandson (Jacob) did not pitch the past school year, he did catch 2 games and started all the rest at shortstop.... We do have fun!
I have 2-more games yet today so more opportunity to use the 70-300. You have fun and let us see some ballgame photos.
BTW, I recently saw some of your 'flies' photos, quite impressive and I know that hobby is a LOT of enjoyment.
Thanks for the remarks,
|Jun 14, 2008, 12:16 PM
Senior Member
Join Date: Sep 2003
Location: Dallas, Texas USA
Posts: 6,589
Nice shots, Bob. It definitely takes some dedication to be out in the middle of the day these days down here, but it was obviously worth it. And now you get to do it again for 2 more games! That's a lot of baseball, but it always went by faster than I wanted when it was my daughter playing softballwhen she was in high school. I'm sure it'll be the same here with you. Have fun and fill up all of your cards!
|Jun 14, 2008, 12:53 PM
Senior Member
Join Date: Aug 2004
Posts: 4,555
Hi Bob!
Good to see you shooting with the new lens! Nice pics of the game esp 3 and 4 being my favorites.
: o )>
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I AM CARDBOARD® Newly Improved Virtual Reality Cardboard Kit without NFC Tag-Google Cardboard Exact Specification (With Assembly Instruction and Numbered Tabs). Pre-built cardboard comes with printed numbered tabs and image instructions printed on the package itself for easy folding of Google cardboard in seconds. NOTE: THERE IS NO NFC TAG FOR THIS ITEM.
- Complete Kit without NFC, pre-built and assembled in seconds.
- Easy to assemble. With Printed Instructions and easy to follow numbered tabs.
- Biconvex lenses 25mm in diameter and Focal length 45mm (exact google cardboard specification)


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I was buying a jar of jam at the sutler's tent when the cannon went off, close enough and loud enough to make my teeth rattle and my eyes widen into an excellent impersonation of fear. The salesman, a stout, bearded fellow in the woolen blues of a Union soldier, barely blinked. As he handed me my credit card, I could read his thought _ a greenhorn!
But I was enjoying every minute of it.
A few months ago, attending the re-enactment of a U.S. Civil War battle wouldn't have been high on my to-do list. I had never fired a gun in anger (I had surfed through the Vietnam War on a college deferment, a high lottery number and a deaf right ear) and I could not see the point of grown men dressing up in funny clothes and firing blanks at one another all weekend.
Then, to help my mother, a genealogy buff, I began to poke around genealogy sites on the Internet and dig up factoids on the Civil War service of my great-great grandfather, William Rea. A private with the 45th Ohio Volunteer Infantry regiment, Rea had had a hellacious war, spending nine months in the Confederate prison camp at Andersonville, Ga., a notori ous forcing ground for malnutrition and disease, where 12,912 of the 45,000 prisoners died. Rea survived, but spent the next two years as an invalid and never completely recovered from his ordeal.
Rea's regiment, however, had the distinction (or frustration) of chasing famed Confederate raider John Hunt Morgan for three weeks through Kentucky, Indiana and Ohio, finally running him and his 2,000 men to ground near Buffington Island, on the Ohio River, where Morgan had intended to ford to friendly territory. Instead, in the Battle of Buffington Island, on July 19, 1863, Morgan suffered a crushing defeat at the hands of the 45th and other Union forces. Though Morgan himself escaped, 700 of his men were captured, 57 were killed and 63 were wounded. Meanwhile, 21 men on the Union side died.
The Battle of Buffington Island may not rank high among Civil War conflicts, but it was one of only three battles fought on Union soil. Also, the battlefield has become embattled itself: A local company has received a permit to mine gravel on 600 acres of it, and the re-en- actors who organized a three-day event from July 16-19 to commemorate the battle's 136th anniversary intended to use every opportunity to protest this desecration.
Reading all this and more on the Web (see www.civil warhome.com /buffington.htm for details) I decided to make the re-enactment part of my next trip to Ohio. What was I getting into?
What I found when I arrived at the battle site, on a sweltering July day, was a Civil War-era camp sprung to life, from the white tents of the soldiers to the hoop skirts of the women. There were jarring notes (kids in cut-offs and T-shirts guzzling pop at a picnic table) but the overall effect was that of walking into an impromptu history theme park. All the re-enactors _ about 150 soldiers from both sides _ were not only in costume but, to greater or lesser extent, acting their 19th-century parts. No one was listening to a ball game on a Walkman or closing a deal on a cell phone.
Instead, a woman was intently explaining to a small crowd of visitors how she and other volunteers of the U.S. Sanitary Commission tended the wounded _ and sold homemade jam and other comestibles to support their activities. A man costumed as a Civil War-era peddler, right down to his ragged goatee, was hawking fresh eggs with a smooth line of patter that would have done an Asakusa banana seller proud.
Meanwhile, two Confederate soldiers were silently examining the Buffington Island battlefield marker, where tiny Confederate battle flags had been placed in the ground _ one for each of the fallen soldiers. "My great-grandfather fought for the Confederacy, but when we were growing up we never heard any stories about what he did," said one soldier who, with his period glasses and brush mustache, looked like a younger Teddy Roosevelt. "I guess a lot of the soldiers kept quiet _ they didn't think the folks back home would understand what they had been through."
Re-enactors, however, have been anything but quiet. Spurred by the revival of interest in the Civil War in the past decade, re-enactment units and events have been proliferating. The Camp Chase Gazette (users.qual.net/~civilwar), the leading re-enactors magazine, announced dozens of events in all parts of the country in its July issue, along with a long list of ads by regiments in need of volunteers.
Investigating this phenom- ena in his best-selling book "Confederates in the Attic," Pulitzer Prize-winning re- porter Tony Horwitz found that many re-enactors, espe- cially the ones who styled themselves "hard-core," were not just grown-ups playing soldier, but amateur historians dedicated to get- ting every aspect right, from the number of stitches on their uniforms to the stories they told around the camp- fire. One of Horwitz's princi- pal informants and guides, a Confederate re-enactor named Robert Lee Hodge, had even perfected what his admiring friends called "the bloat" _ the round-mouthed, swollen-bellied pose of rigor mortis often seen in Civil War-era photographs of dead soldiers.
Hodge, now a celebrity in re-enactor circles, made an appearance at Buffington Is- land (and posed solemnly in uniform for a Columbus Dis- patch photographer), but you didn't need to be hard-core to understand the appeal of slip- ping into another era for a day or two. In one sense, it was like becoming instantly Amish _ one could leave the static of our wired world far behind. In another, it was like being an extra on a movie set, with all the thrill of being in character, but without the boredom of waiting for the clapper to come down.
Lights, camera, charge!


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Martha Marcy May Marlene
| 94 votes and 32 Reviews Write a Review
Release Date:
- October 28, 2011 - Limited
DVD: February 21, 2012
1h 41m | Drama, Thriller
Martha (Elizabeth Olsen) is a young woman rapidly unravelling amidst her attempt to reclaim a normal life after fleeing from a cult and its charismatic leader (John Hawkes).
Seeking help from her estranged older sister Lucy (Sarah Paulson) and brother-in-law (Hugh Dancy), Martha is unable and unwilling to reveal the truth about her disappearance. When her memories trigger a chilling paranoia that her former cult could still be pursuing her, the line between Martha's reality and delusion begins to blur.
|Sean Durkin
|Fox Searchlight Pictures
|Antonio Campos, Chris Maybach, Josh Mond, Patrick Cunningham
|Elizabeth Olsen, John Hawkes, Sarah Paulson, Hugh Dancy, Brady Corbet
|Sean Durkin
|Official Site:


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Down Syndrome Sphere of Influence by SWH
An Introduction
What is Down Syndrome?
As simple as this question may sound, there is so much information about Down Syndrome that it cannot be answered in a few sentences. This is because Down Syndrome is part of many spheres of influence.
All human beings are a part of many spheres of influence and Down Syndrome is no different. Moreso, humans have many domains of health such as biological, physical, cognitive, mental, behavioral, intellectual, social, etcetera. How and where each individual is, is independent, as a result of their uniqueness. How they interact with the greater whole, is dependent on their ability and how others perceive their contribution of those abilities. This is the definition of society; the individual as a whole and how many different wholes make up the greater whole. Not to be confused with the analogy of a puzzle, because puzzles are pieces and each individual is a set of puzzle pieces and not one piece alone.
The center is made up of the self. Outside of the self are many influences and levels of society where interactions influence one another's' life experiences. With this ideology, to answer "What is Down Syndrome?", I will begin first with the individual, move on to family, and then to the various levels of influence that make up society.
It is my endeavor to answer "What is Down Syndrome?" in a way that will show that Down Syndrome is more than just a medical term, it is representative of a truly awesome rainbow of people, instead. After all, a rainbow would be very dull if all the colors were all the same.


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Set bluetooth baudrate to () for Oscilloscope is a stack block available in Dabble extension for evive. The Oscilloscope module allows you to visualize the input and output signals of your hardware device on your smartphone. This block for setting the baud rate by selecting one from the drop-down for the Bluetooth module that you have connected to evive.
In the given script we will visualize the voltage level across an analog pin on evive. For this, we will follow the following steps:
- Read data of analog pin. You can connect any sensor or a simple potentiometer in which you can get a variable output voltage between 0 and 5V.
- Convert it into millivolts.
- Send it to Smartphone so that it's graph can be plotted.
In both the scripts given below, a function block is defined that converts analog reading read by hardware into millivolts.


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Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome
UMMS Affiliation
Department of Surgery; Department of Medicine, Division of Gastroenterology
Publication Date
Document Type
Adult; Aged; Burns; Cell Separation; Humans; Immune Tolerance; Indomethacin; Middle Aged; Monocytes; Prostaglandins E; Rosette Formation; Shock, Septic; Tumor Necrosis Factor-alpha
Gastroenterology | Immunology and Infectious Disease
Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (MO) functions, depressed immune functions, and poor clinical outcome. The trauma patients' FcRI+ MO subpopulation produced the majority of their elevated IL-6, TNF alpha, TGF beta, and PGE2. IgG stimulation of patients' MO through FcRI not only stimulated TNF alpha, IL-6, and PGE2 levels, but also greatly augmented the levels of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal B-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FcRI on the increased numbers of FcRI+ MO leading to ever-increasing monokine levels. IL-4 was found to downregulate patients' FcRI+ MO production of mediators. The cycle of altered cytokine levels, increased FcRI+ MO numbers, elevated IgG, and augmented triggering of FcRI+ MO may be broken by addition of IL-4.
J Trauma. 1990 Dec;30(12 Suppl):S86-96.
Journal/Book/Conference Title
The Journal of trauma
Related Resources
PubMed ID
Repository Citation
Miller-Graziano CL, Szabo G, Kodys K, Griffey K. (1990). Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome. Gastroenterology Publications. Retrieved from https://escholarship.umassmed.edu/gastroenterology_pp/11


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Boys Junior Varsity Tennis, Boys Varsity Tennis · Boys Varsity Tennis falls to Freeport 3 – 2
3 - 2
February-March (25-9) Calendar 2019
All boys interested in participating on the Boys Tennis team this Spring should attend a meeting on Monday, February 25th after school at 4:00pm in room E144 (Mr. Dredge's classroom) at the HHS Main Campus. Boys Tennis is a NO CUTS team, and all interested participants should attend! Freshman players should take the Activity Bus


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There are plenty of causes why providers spend on business inside designers to produce their work destinations far more presentable and pleasing. Business fit out providers are in desire at this time thanks to the mounting will need of businesses to enhance their do the job setting even though maximising the offered area. An inside office design and style that is nicely planned can persuade efficiency and optimistic frame of mind among the personnel even with the every day challenges they come across at get the job done. In turn, the firm will advantage from the greater high-quality and amount of work accomplished by their staff members. A very good inside style and design is vital on account of this and a lot more. You can get the inside on this website Office Renovation Services.
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Immediate Improvement around the Lights Inside the Office
A brilliantly developed business inside will definitely have superior lights. That is important primarily because almost all of the function within an office environment is finished utilizing a computer as well as improper lights can have an effect on convenience and even health of the staff members. An inside designer to the office will cautiously analyze and issue in shadows and light that tumble in the unique spot if you want to cut back glare from equally organic light-weight from your home windows or even the lights mounted while in the place of work. Various kinds of lighting might also generate a space sense smaller sized or bigger, so arranging in advance which one particular to employ will response for the whatever the corporation needs to attain. Even the color of the lights can have an affect on people today, as some may conveniently result in head aches.


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That's not really a surprise.
What's interesting to me is just where the doodle is being displayed. I just checked a few of the dozens of local country-level domains Google has.
It's on the UK site, of course. It's also on the Australian, Canadian, and New Zealand sites. None of that's a big surprise, either. But it's not on the Gibraltar, Guernsey, Jersey, or Manx sites, and all of those are still part of the UK: an overseas territory and three Crown Dependencies.
It's also not on some former British colonial possessions, like Hong Kong, Ireland, Singapore, or South Africa. I can think of good reasons why not in each case.
But it is on the one for the United States, that long-lost British colony. It's also on the one for India.
Sure, from a marketing point of view, I can see their choices making sense. But it's still funny.
ETA: TG Daily's "Royal Correspondent" suggests "that Larry Page is after a knighthood."


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