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The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV. However, flavivirus mutations accumulate with time, increasing the likelihood that genetic viral differences are determinants of change in viral phenotype. Based on comparative ZIKV complete genome phylogenetic analyses and temporal estimates, we identify amino acid substitutions that may be associated with increased viral epidemicity, CZVS, and GBS. Reverse genetics, vector competence, and seroepidemiological studies will test our hypothesis that these amino acid substitutions are determinants of epidemic and neurotropic ZIKV emergence.
Zika virus (ZIKV) was first described in the African forests, where it circulates between nonhuman primates and sylvatic mosquitoes (1). More than 60 years after its discovery, fewer than 20 human infections had been reported. The first ZIKV epidemic occurred in Yap, Federated States of Micronesia, Pacific, in 2007 (2). Based on a serological survey, 73% of the inhabitants were infected. ZIKV then disappeared epidemiologically until a large outbreak occurred in French Polynesia (FP) in 2013 to 2014. The outbreak was the first in which congenital Zika virus syndrome (CZVS), Guillain-Barré syndrome (GBS), and non-vector-borne transmission (materno-fetal, sexual, and posttransfusion) occurred (1, 3). Retrospectively, cases of microcephaly were reported in the offspring of 1% of women calculated to have been infected in their first trimester of pregnancy during the FP outbreak (4). Subsequently, ZIKV continued to spread in the Pacific region (1) and emerged in the Americas in 2015. The emergence was associated with a dramatic increase in microcephaly (5–7), a manifestation of the congenital Zika virus syndrome (CZVS), leading WHO to declare a global health emergency. Concomitantly, the number of infected visitors returning from the Pacific and Latin America to their homelands in North America, Europe, Asia, and Australasia was increasing, thus extending the risk for ZIKV in areas in which the Aedes ZIKV-competent mosquito is present.
Two ZIKV lineages have been described: African and Asian. Strains that emerged in the Pacific Islands and Latin America belong to the Asian lineage. In late 2015, a ZIKV outbreak due to an Asian lineage strain was also associated with cases of microcephaly. It occurred on Cape Verde off the coast of Africa (1). These data suggest that the severe neurological complication of ZIKV infections (GBS and CZVS) are associated with the strains that emerged in French Polynesia and subsequently spread to the Pacific Islands and Latin America and back to Africa at least to a coastal island.
How did ZIKV emerge from its sylvatic forest existence to cause major epidemics throughout the Pacific and the Americas? Similar to dengue virus (DENV), ZIKV had the potential to adapt from a sylvatic cycle involving sylvatic mosquitoes and nonhuman primates to an urban cycle involving urban/suburban mosquitoes and humans (1).
One possibility is that the emergence of ZIKV is simply a consequence of the increasing global human population, increasing population of competent mosquito vectors, increasing urbanization, and increasing global transportation of commercial goods. Lack of ZIKV-specific population immunity was almost certainly a contributing factor to the emergence of ZIKV. Additionally, the possibility of immune enhancement arising from cross-reactions with related viruses such as dengue virus cannot be ignored (8). However, we share the view of Musso and Gubler that genetic changes are the most likely explanation for the dramatic emergence and neuroinvasiveness of ZIKV (1). This concept is supported by observations that genetic changes associated with vector specificity and epidemic potential in chikungunya virus (9) and increased virogenesis in West Nile virus (10) have been reported. Accordingly, to study the possible effect of nonsynonymous mutations in the open reading frame and changes in the 5′ and 3′ untranslated regions (UTRs), we investigated the evolution of ZIKV through analysis of an extensive range of complete ZIKV genomic sequences. We identify amino acid changes that arose progressively throughout the viral genome as the virus emerged out of Africa and gradually dispersed across Asia, the Pacific, and Latin America and the more restricted changes that occurred in the untranslated regions. Importantly, we highlight and discuss specific amino acid substitutions that are directly associated with the appearance of the altered epidemiological and neurotropic characteristics of epidemic Pacific/Latin American ZIKV.
Methods.To explore the temporal evolution of ZIKV, representative and robust complete ZIKV sequences available as of 29 May 2016 were retrieved from GenBank (http://www.ncbi.nlm.nih.gov/genbank). At the time, only one isolate was available from French Polynesia (FP). To study the possibility that some FP isolates had the mutation M/T2634V first documented in the Latin American strains, an additional 13 isolates from various times and places in the FP outbreak were sequenced in house. The in-house next-generation sequencing was performed with the Ion PGM sequencer (Thermo, Fisher Scientific), and analyses were conducted with the CLC Genomics Workbench software. RNA was extracted from serum or cell supernatant medium using the EZ1 Mini virus 2.0 kit and the EZ1 advanced XL machine (both from Qiagen). Complete virus genomes were amplified in 3 or 12 fragments using specific sets of primers with the Superscript III one-step reverse transcription-PCR (RT-PCR) Platinum TaqHifi kit (Thermo, Fisher Scientific).
Two alignments were constructed using Mafft v.7.266, keeping the reading frame consistent with amino acid positions: one alignment (see Data Set S1 in the supplemental material) contained only Asian, Pacific, and Latin American ZIKV (n = 67 sequences), and the other alignment (see Data Set S2 in the supplemental material) also included African ZIKV (n = 84 sequences). In addition, separate alignments were constructed for the 5′- and 3′-UTR regions (see Data Sets S3 and S4 in the supplemental material) for those isolates for which the UTRs were available. Evolutionary rates were estimated using BEAST 1.8.3. After model testing, all analyses were run with the SRD06 codon-partitioned model using the general time reversible (GTR) nucleotide substitution model with gamma distribution, a strict molecular clock with a continuous-time Markov chain (CTMC) prior, and a Bayesian skyline coalescent tree prior with a piecewise-constant demographic model. To ensure mixing of individual chains and sufficient effective sample size (>100), each data set was run three times for 100 million generations, sampling every 10,000 generations. After discarding 10% burn-in for each run, consensus files for each data set were produced using LogCombiner and TreeAnnotator (BEAST package). Consensus trees were then viewed and annotated in FigTree 1.3.1 (http://tree.bio.ed.ac.uk/software/figtree/). All computations were performed at the CIPRES web portal (11). The numbers of unique stepwise amino acid changes in the different clades were checked visually and compared in the combined African and non-African alignments using AliView v1.18 (12).
Data Set S1
Copyright © 2016 Pettersson et al.
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Data Set S2
Copyright © 2016 Pettersson et al.
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Data Set S3
Copyright © 2016 Pettersson et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Data Set S4
Copyright © 2016 Pettersson et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Results.Two dated phylogenetic trees were constructed, and they produced identical topologies for the named key nodes. The first tree (Fig. 1) displays the African viruses in a collapsed format and also includes Asian, Pacific, and Latin American ZIKV isolates (Fig. 1). For the second tree (not shown), the African viruses were excluded. The boxes in Fig. 1 connected by dashed lines to the tree identify all amino acid substitutions that occurred beyond each branch (identified as nodes A to G). The 9 highlighted amino acids identified in boxes 2, 3, 4, 6, and 7 identify substitutions that will be discussed in the context of epidemic emergence of ZIKV and GBS/microcephaly. The conclusions drawn from the tree suggest that the African and Asian strains diverged from their ancestor around 1834 (95% highest posterior density interval [HPD], November 1814 to August 1852 [formatted throughout by year-month as "1814-11 to 1852-08"]) (node 1). The most recent common ancestor of the sylvatic African ZIKV emerged around 1889 (95% HPD, 1879-03 to 1898-01) (node 2). Furthermore, our analyses and supporting data extend the accumulating evidence (13, 14) that the Asian ZIKV emerged around 1946 (95% HPD, 1942-04 to 1953-10) based on the analysis, including African and Asian viruses, or around 1966 (95% HPD, 1964-02 to 1966-07), based on analysis including only Asian viruses. Importantly, none of the identified substitutions (Fig. 1, box 1) was accompanied by a change in the sylvatic tendency of the Asian strain isolated in Malaysia.
The first recorded dispersion of ZIKV out of Africa and Asia was to Yap Island (node B). This resulted in an explosive outbreak of ZIKV infection involving 73% of the immunologically naive population. However, as far as is known, this strain did not disperse further. Six years later, another epidemic Asian strain was identified in FP, documenting for the first time an association with microcephaly and GBS (3, 4, 15, 16). Based on the available phylogenetic data, it was considered possible that an FP strain was the source of the Latin American outbreaks of ZIKV disease (17). These authors identified 5 amino acid substitutions in the ZIKV prM protein that led them to predict major structural change in this protein. Nevertheless, the tree (Fig. 1) shows that 4 of these substitutions (at amino acid positions 143, 148, 157, and 158 of the prM protein) occurred in the Malaysian strain of ZIKV, which, in common with African ZIKV, caused only sporadic infections. The fifth of the prM substitutions, 153, did not occur until after node A, at which point all isolates, with the exception of the Philippine strain, were associated with epidemic spread.
Node B also identifies the point beyond which the ZIKV E protein receptor VGD changed to VGE via the amino acid substitution D683E. In general, the viral receptor plays an essential role in epidemic spread. This concept is supported by studies with a genetically engineered dengue 2 virus (DENV2) receptor loop (VEPG), which show a direct correlation between the receptor sequence and the ability of DENV-2 both to infect mammalian cells and to be transmitted by Aedes aegypti (18). Two additional and potentially important E protein amino acid substitutions, T777M (TM2; node C) and V763M (TM1; node D), were identified. These amino acids associate with the transmembrane (TM) region of infected cells and may play an active role in maintaining stability of the pH-induced trimeric E protein and also in mediating membrane fusion (19).
However, the Philippine and Micronesian isolates retained the African TM1 and TM2 amino acids (V763 and T777). The Cambodian isolate (node C) retained the African V763 TM1 amino acid but acquired the Asian 777M TM2 amino acid. The Thailand virus isolate identified by node D retained the Asian 777M and acquired the Asian amino acid substitution 763M and the second Thailand isolate identified by node E, retained the Asian 777M and 763M but in addition acquired Y2086H (Fig. 1). Thus, the Malaysian, Micronesian, Philippine, Cambodian, and Thai viruses may represent the final progressive evolutionary stages that endow ZIKV with epidemicity before the critical substitution that appears to coincide with emergence of neurotropic ZIKV in FP.
The first appearance of a French Polynesian virus in the tree is identified by node F. Node F1 identifies a branch with 3 Samoan viruses and 6 FP viruses, and node F2 identifies another branch with 5 FP viruses. Node F3 distinguishes a branch with 2 more FP viruses, which are the most closely related FP viruses to the Latin American viruses, identified by node G. Thus, nodes F, F1, F2, and F3 define 14 FP and 3 Samoan viruses that evolved in FP/Samoa over a period of less than 3 years. Note that nodes F1 to F3 are distinguished only by synonymous and sequence-specific nonsynonymous mutations.
Node F identifies the evolutionary point of emergence of epidemic neurotropic ZIKV, and this coincides precisely with the appearance of the amino acid substitution S139N in both the French Polynesian and Samoan isolates (Fig. 1, nodes F and F1). Recognition of the presence of ZIKV in human semen also coincides with the appearance of the S139N substitution. However, this may reflect more intensive study of ZIKV after its discovery in FP (20).
Amino acid 139 is in the ZIKV M protein, a transmembrane (TM) protein. While the function of this amino acid has not been defined for ZIKV, in DENV2 the equivalent amino acid is involved in the acid pH-mediated viral surface maturation process (21). Thus, all ZIKV isolates from FP onwards possess a VGE receptor sequence via the substitution D683E, the E protein TM1/TM2 substitutions (V763M/T777M), and the closely associated M protein TM modification (S139N).
Node G defines the point at which the substitution M/T2634V arises. Thus, the tree shows clearly that GBS and microcephaly, which were first reported in FP, arose following the S139N substitution in the ZIKV M protein. None of the FP isolates had the M/T2634V substitution found in the Latin American isolates. Although it will require further verification, the substitution most likely arose after ZIKV escaped the Pacific. Whether or not the M/T2634V substitution contributed to the recognized increased incidence of microcephaly in Latin America compared with the Pacific is a matter for conjecture until further relevant virus isolates become available or experimental evidence is obtained.
Did the five unique amino acid substitutions defined above—i.e., D683E (box 2), T777M (box 3), V763M (box 4), S139N (box 6), and M/T2634V (box 7)—have an impact on mosquito vector competence of epidemic ZIKV and increased ZIKV neurotropicity? These questions will be investigated using reverse genetics methods combined with vector competence and seroepidemiological studies.
The acquisition of four additional amino acid substitutions, including one in the NS4B protein (A/G2283S) and three in the NS5 protein (A/T3046I, G/R3107K, and R/S3167N), distinguishes African/Malaysian from other non-African ZIKVs (Fig. 1, box 2). These may have perturbed the intracellular interferon type I pathway (22). Additionally, as components of the viral replicative complex, these unique substitutions may contribute to enhanced viral replication (21, 23).
Comparative analysis of the 5′ and 3′ termini that form secondary structures in the untranslated regions (UTRs) of the ZIKV genome revealed differences between African and all other ZIKV isolates studied (Fig. 1, box 1; see Data Sets S3 and S4; see also Fig. S1 and S2). However, since all of these changes preceded the dispersion of ZIKV to both Micronesia and separately the Pacific region further east, they are unlikely to have been primary determinants of ZIKV epidemicity, although they may make a supplementary contribution. Another factor, not revealed by current analyses, is the influence of defective interfering virus particles. In DENV, such particles have been associated with increased epidemic potential (24).
Figure S1
Copyright © 2016 Pettersson et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Figure S2
Copyright © 2016 Pettersson et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Estimated mean evolutionary rates (MERs) and times to most recent common ancestor (tMRCA) based on strict molecular clock estimates, using trees that include or exclude African viruses, are also presented (Table 1; see Data Sets S1 and S2 in the supplemental material). Estimated MERs for the tree that included African viruses (6.30 × 10−4; 95% HPD, 5.5 × 10−4 to 7.1 × 10−4) were lower than those for the tree with African viruses excluded (1.20 × 10−3; 95% HPD, 1.1 × 10−3 to 1.3 × 10−3). Divergence of African and Asian ZIKV from a most recent common ancestor occurred around 1834 (95% HPD, 1814-11 to 1852-08). Subsequently there was a significant increase in the mean evolutionary rate of the Pacific/Latin American variants of ZIKV, an observation consistent with marked increase in virus transmission and turnover accompanying the massive island and urban outbreaks. tMRCA estimates indicate that the introduction of ZIKV into the Americas (Fig. 1, node G) occurred in November 2013 (95% HPD, 2013-10 to 2014-02). Although the timing is not significantly different from December 2013 (95% HPD, 2013-08 to 2014-04) of a previous estimate (13), the window of introduction is narrowed.
Our phylogenetic and comparative amino acid analyses revealed four unique amino acid substitutions: one (D683E [box 2]) was located in the viral receptor site, two (T777M [box 3] and V763M [box 4]) were located in the viral envelope protein, and the final but possibly the most critical one (S139N [box 6]) was located in the M protein. These amino acids clearly play important roles in virus attachment entry, release, or maturation of the virus during the infectious process. Thus, three unique amino acid substitutions directly associated with virus infection and transmission efficiency occurred just prior to the emergence and widespread dispersal of the highly epidemic and neurotropic ZIKV. The appearance of the membrane protein substitution S139N coincided precisely with the appearance of GBS and CZVS in FP. While this does not prove cause and effect, it appears to be more than a coincidence. Another unique substitution, in the NS5 protein of ZIKV (M/T2634V [box 7]) was identified in all Latin American viruses and may also impact neurotropicity since the relative rate of CZVS increased significantly in Brazil compared with FP.
Other substitutions in the prM and E glycoproteins could either be compensatory or could alter virus characteristics, such as hydrophilicity and charge. As reported for DENV mutants, the ZIKV mutants show efficiency for producing neurovirulence (25) and adsorption-mediated endocytosis (AME). (AME depends on electrostatic/hydrophobic interactions between the virion and cell surface [26].)
The emergence of ZIKV and its widespread dispersion throughout the tropics and subtropics have undoubtedly been influenced by increasing human mobility, urbanization, and failure to reduce the spread and expanding population density of ZIKV Aedes species vectors. The recent discovery that ZIKV is significantly more thermostable than DENV may also contribute to its success as an epidemic virus through its ability to reproduce to higher levels of viremia and to resist inactivation under unfavorable environmental conditions (27).
The use of reverse genetics, vector competence studies, and seroprevalence analyses to gain an understanding of the epidemic potential of ZIKV will enable the validity of our observations and hypotheses to be tested both in vitro and in vivo.
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. J.H.-O.P., V.E., D.M., A.N., R.C., E.A.G., and X.D.L. are members of the ZIKAlliance programme of the European Union.
- Copyright © 2016 Pettersson et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.


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World Design Week
7-19 November 2017 LDW is a meeting platform for the different Read more
30 May - 6 June 2018 St. Petersburg Design Week is the annual event which Read more
2-11 March 2018 It is the 20th anniversary of the Sydney Design Festival. Read more
7th -10th March 2018 Design Week in Querétaro is an international festival Read more
7th -11th November 2018 Contemporary Art Fair, MAG – Montreux Art Gallery – Read more
10-16 September 2018 Tallinn Design Festival is a significant annual event Read more
5-14 June 2018 Barcelona Design Week (BDW), organised by Barcelona Design Read more23th -29th September 2017 A volunteer organization formed in 1983, The Read more7th -13th October 2017 St. Louis Design Week is a seven-day celebration of Read more30 June - 1 July 2017 Bangkok Design Festival took place for the first time Read morein ALL, Jul, Jun, world design week 0 comments018 September - 2 October 2017 Tirana Architecture/Design Weeks (TAW/TDW) Read more7-13 May 2018 Vancouver Design Week (VDW) is the city's official Read more10-14 October 2018 Since 2009, Design Week Mexico has been the city's most Read more1-30 September 2018 Capitalizing on the chance of hosting 2009 World Design Read more7th-15th June 2018 From tech inventions to culture changing products, human Read morein ALL, home, Jun, world design week 0 comments014th - 21th April 2018 Design Week Portland is a week-long, city-wide series Read more022-24 May 2018 Clerkenwell is home to more creative businesses and Read more20th -24th June 2017 Medellin Design Week is a space of Read more07 October 2017 Founded in Sydney in 1999, Indesign Media Asia Pacific Read more12-17 March 2017 Read more20th -28th October 2018 In October of each year, Dutch Design Week (DDW) Read moreOctober 2017 (Not Final) Creative celebration celebrating Read more20-26 August 2018 4-10 February 2018 The first-ever Stockholm Design Week Read more17th -21th September 2018 For decades Cincinnati has placed itself at the Read more3-7 October 2018 The Lisbon Design Show (LXD) is an event Read more11-12 August 2017 Indesign: The Event is a boutique design experience Read more05th - 9th March 2019 Bogotá is a 4 day event that brings Read more1st -30th September 2018 Design is Everywhere. It's an integral part of our Read more7th -13th February 2017 BAHRAIN INTERNATIONAL DESIGN WEEK (BIDW) is Read more029 September - 7 October 2018 VIENNA DESIGN WEEK is Austria´s largest design Read more5th -9th December 2018 Design Miami/ is the global forum for design. Each Read more017th - 22th April 2018 one of the widest design event in the world! Read more9-17 March 2019 Munich and Bavaria as a site for creative activities stand Read more3rd -4th October 2016 (it's not repeated in 2017) China has become the Read more4th -10th May 2016 ( it's not repeated in 2017 and 2018) The festival was Read more2nd - 9th March 2018 The Udine Design Week was from Friday 2nd Read moreVenice Design Week 6-14 October 2018 12-20 October 2019 Venice Design Read more16 October - 23 November 2018 Month of Design is an annual festival of Read more020 February 2017 Cities that use design as a tool to think, to act, and to Read more19-25 February 2018 WELCOME TO THE WORLD'S MOST NORTHERN DESIGN WEEK IN Read more03rd - 6th November 2016 ( it's not repeated in 2017) The Read more14th -20th January 2019 DISCOVER INTERIOR IDEAS: The first interiors show of Read more6-16 September 2018 Founded in 2005, Helsinki Design Week is the largest Read more17-18 November 2017 The aim of "SELECTED from Bilbao" is to provide an Read more29 August - 2 September 2018 Brazil is definitively inserted on the top Read more012-17 November 2018 Dubai Design Week is one of the world's newest and most Read more11th -15th October 2017 Russian market requires particular approach that Read more23 September - 2 October 2016, It won't be held in 2017 Initialed in 2007, Read more21th -29th October 2017 Sheffield Design Week is a citywide celebration of Read more4th - 11th May 2018 The third week of design in Zlín brings the newest Read more3rd week of March and October Philippines Design Week is a multi-faceted Read more3-12 March 2017 Singapore Design Week (SDW) is marching forward and Read more20-28 May 2017 THE Institute is an ecosystem for creative industries in Read more15-18 March 2018 DesignMarch is Iceland's most Read more22-29 June 2018 Established in 2012, Beirut Design Week is the largest Read more11th —16th May 2018 Since 2014, Tianjin International Design Week has Read more6-15 September 2018 Paris Design Week is an itinerary uniting 300 Read more27th November - 1st December 2107 First organized in 2013, the International Read more021-27 May 2018 Prague Design Week – designers exhibition continues the Read more18-27 January 2018 TO DO advances design culture in Canada. We build a Read more016th -26th March 2017 Melbourne International Design Week aims to highlight Read more5th - 12th October 2018 Phoenix Design Week is the premier annual event Read more22-26 November 2017 Read more14-17 March 2018 Design Shanghai is one of the world's most prestigious Read more15-23 September 2018 London Design Festival was conceived by Sir John Read more11th -12th November 2018 Now in its eighth year, Boutique Design New York Read more12th -17th June 2018 Design Miami/ is the global forum for design. Each fair Read more19th - 22th September 2017 The aim of the VDW is to support, Read more

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Edwina & CharlieIt's easy to look at a wedding and miss the beauty in the details, but that's exactly what's good in Edwina and Charlie's sweet Wollombi country wedding. The couple's four legged friend making an appearance, the special family toast, the nod to the bride's parent's wedding in the groom's attire, a special song
Alex Winner Photography
Teagen & JessWe're incredibly fond of elopements at Polka Dot Bride, and we know, that one of the hardest parts of running off with your beloved to tie the knot, is missing out on a celebration. For Teagen and Jess, their elopement in Vegas was the most perfect excuse to celebrate with their friends and family. They
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3 Rankers Reviews
1 Face-to-Face
286 Walking
3 Palmerston
South Island ▷ Coastal Otago ▷ Palmerston
Fergus Power
Ranking: 10/10
Beautifully peaceful place rich with birdsong, with some fascinating geology and superb views....
Save up to 70% on campsite fees! Support conservation and experience the natural beauty of NZ. 78 Department of Conservation campsites, one convenient pass.
Chandra Holt
Ranking: 6/10
Two options for hiking, one is 30 minutes return to see the caves and the other is 1 hour 30 minutes return just a loop through the woods. A man was hunting there with his dogs, other than that we were alone. It's a steep incline and parts of the trail had fallen trees from a mudslide. Do not go if it's raining!! Very slippery and steep. Beautiful natural forest and peeking views to the gorge but not what we expected. A great workout, the views are okay, and not a very safe trek in wet weather. Maybe on a sunny day it's more rewarding.
Access savings worth hundreds of $$ on Top Ranked NZ Accommodation and Activities for just $1 per day.
Arthur Langlume
Ranking: 9/10
Nice walk along gorges with ocean views.
Thanks to all the good people working for the NZ Department of Conservation - for all your hard work - making NZ more beautiful, accessable and healthy! Cheers 😍


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A BUSINESSMAN who built a £1m mansion without permission has won his battle against a demolition order.
Azam Yaqoob, 36, is celebrating after being told he will not have to flatten the property in Huddersfield Road, Mirfield.
His victory comes after a two-day appeal hearing last month.
Kirklees Council had served him notice to demolish the nine-bedroom house which had been branded an eyesore by neighbours.
But the inspector who chaired the appeal has ruled in favour of Mr Yaqoob, subject to conditions involving removal of windows overseeing other properties and reducing the size of gate pillars.
Mr Yaqoob, who runs Mr Sparkles car wash in Dewsbury, was delighted after hearing the news.
He said last month he felt "optimistic" he would win the appeal.
The businessman reportedly paid £300,000 for the plot in 2003 and began extending the existing 1920s mock Tudor property.
He demolished most the original house and built a largely new structure.
His action was described as "cavalier" by the council.
But Mr Yaqoob said the house was not that big and was in keeping with others in the area.
More than 70 members of public packed into Huddersfield Town Hall for last month's inquiry, with several residents speaking against the home.
Kirklees Council said the defeat would not put it off taking a firm line against developers who it felt had broken the rules.
Council deputy leader Ken Sims said: "There a lot of people in Mirfield who supported the stance taken by the local planning committee and local councillors in relation to this development not being carried out in line with the approved planning permission.
"They will no doubt be disappointed with the planning inspector's decision."


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King Upholstered Headboard Unit
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Fall Steering Committee Meeting
August 29, 2018 @ 2:00 pm - 4:30 pm
This meeting will focus on getting everyone updated on the progress made since our summer steering committee meeting and planning for the large group RNPP meeting in September. We'll also welcome Greg Weber, RBP's new ED and talk about how RNPP and RBP interact with one another.


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Michelle Sargeant Posted 04 Jan Flew to Goa. Qatar flight from Doha to Goa and the return was very cramped. Food on this flight was also of a poor standard.
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Flightline » Flights » India » Flights to Goa. Dabolim Airport is located in the village of Dabolim in Goa, India.
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I have the potency to act. I have the potency to write. Every one has. Only the perfect act has not potency anymore. An act is relative to its proper potency. The perfect act relative to the potency of writing is the Iliad, Moby Dick, Dune. Potency is imperfection. Most acts are also imperfect, only less. The prototypical imperfect act of writing is what I am doing right now.
Four Categories of Being
My last post on Aristotle's "Metaphysics" didn't amount to much, I know. But now it will get worse. Because I need a long digression in order to prepare the terrain for that elusive thing which is understanding. Aristotle first defines substance in the "Categories", a work usually considered to be prior in time to the "Metaphysics", and one which should be read first too. There he explains the foundations of many terms he uses afterwards in all of the corpus. There is also where he introduces his famous ten categories of being. All I want here is to get to the first category, but allow me to walk the whole way there.
What the Hell is Substance?
For the vast majority of my life, I have favored reading nonfiction over fiction, using the argument that since "truth is stranger than fiction", why waste my time with "invented truths"? Needless to say that I was profoundly wrong. But I say that now just to explain why, during that same stretch of my life, I have read nonfiction as if it were fiction. I read it page by page, enjoying the mystery of understanding gradually unfold in front of my eyes, yearning to reach the end of the book as if the murderer of an Agatha Christy's story would be revealed. It was this naive (not to say stupid) that I made a feeble attempt to face Aristotle's "Metaphysics" three years ago. The trauma was so strong that only now I am recovering. Boy, I wish I believed in God or any lesser superstition! Because now I'll need all the help I can muster to wrestle with this tome.
O.P.A.R. – Commentary: Man Qua Man
As I said in my crazy post about "Dune", reason is the word of Objectivism. Chapter 5 of O.P.A.R. established that it is only through reason (not emotions) that we acquire knowledge about the world; and Chapter 6 has established that it is only through reason that man survives. I will no longer delve into (i) for now, but I think (ii) needs a little more attention.
The Forgotten Book of the "Metaphysics"
Aristotle's "Metaphysics" begins by saying that "All men by nature desire to know." He, of course, regarded as "men" a select few — the Greek citizens — not the majority of the Greek people made up of slaves — beings who had allowed themselves to be conquered, inferior beings — much less the non-Greek barbarians. Perhaps the problem is precisely this: most of us must be descended from slaves, and as Will Durant put it, it must have been slavery that prepared us for the habit of toil. If this were not the case, we wouldn't work so hard and think so little. Because when I look around me, I do not see many people interested in knowing. In fact, I see almost no one.


text: I am an innovative and creative product designer from San Diego, California. I'm always thinking of new ideas, what's next, and keeping on top of the newest trends and styles culturally, artistically, fashionably, and technologically. My motivation while designing is the reward of designing something aesthetically beautiful as well as functional, while pushing the boundaries of design and innovation. A few words that describe me and my style as a designer and an artist are innovative, organic, inspired, cultured, clever, imaginative, authentic, copacetic, avant-garde.


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Nothing has been or will be said about the Bears quarterback situation coming into a game but the final exam for Caleb Hanie and the Bears season is at hand. No more, no less.
But if the Bears struggle through another first half with Hanie they have never led after two quarters in his three starts the calls for Josh McCown are likely to be loud and clear Sunday against the Seattle Seahawks.
The Bears were averaging more than 30 points per game in their five-game win streak under Jay Cutler. They have totaled 33 points in their three under Hanie.
Hanie was handed an unwanted audition with the injury to Cutler. He is an unrestricted free agent after this season. People are watching.
I'm not worried about it personally, said Hanie, who has had good stretches and horrendous ones. All I'm worried about is the team. It's a critical stretch for the team. We've got three games. We're in the playoff hunt still.
We're confident that if we win out that other teams will slip up. And we're confident in the guys we have. So I'm not worried about any personal goals or agendas at this time, besides getting better and making the plays I need to make during the game.
It wont be easy for Hanie. The Seahawks are allowing opposing quarterbacks a passer rating averaging 78.6, which is 10th-best in the NFL.
The Martz effect
An irony in the Hanie situation is that the Bears are reaping what Mike Martz sowed, not this year, but well before that.
Under Ron Turner, Hanie was the No. 2 on a two-man depth chart with Cutler. When Martz took over, he wanted a veteran in the stable, which was generally met with public approval of Todd Collins. Or at least until Collins actually played.
Hanie was relegated to No. 3, which gave him less than no work with the Martz offense until he was thrown in after Collins failures at New York and Carolina. The only times Hanie began a game as other than the No. 3 was vs. Seattle and Washington and he didnt play then.
Hes getting better, Martz said last week. Theres no question hes getting better. Hes getting a better feel for the game. The more he plays, the better hes going to get. Hes going to have a long career in the league. Hes basically a rookie learning as he goes.
A second irony here is that Martzs own career well could be riding on Hanies performance. Martz may never have wanted Hanie as his quarterback, but Martzs future in Chicago, if there is one at this point, or elsewhere will depend in some measure on his ability to develop a quarterback, and that now means Hanie.
I have not lost any confidence in him at all. I really havent, Martz insisted. Weve just got to continue to teach and support him and encourage him and not discourage him and just hang in there with him, really.


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Fruits are dark green, almost black, with faint stripes, flesh orange-red like a Sugar Baby only with a cleaner more pleasing texture, very sweet, juicy and crunchy. Drowns didn't rest on his laurels—he now maintains Sand Hill Preservation Center in Iowa, his catalog a treasure trove of rare seed and poultry varieties. OSSI. Breeder Royalties. ②
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Optomizing Glutathione for Health and Human Performance
Many of us, me included, have thought of ways to improve our health in this New Year. Perhaps you have kicked off a new fitness regime or have started a new diet plan. As we begin the journey to better health, I want to bring attention to a molecule called glutathione and its implications for health and human performance.
Glutathione is one of the most powerful antioxidants responsible for maintaining cellular health. It is found in all cells, but is highly concentrated in the brain and liver. Glutathione is a chief biomarker of cellular redox status (electron allocation), meaning it can accept electrons from free radical species. Less glutathione increases the cell's vulnerability to oxidative damage, and consequently increases the risk for disease.1 It is good that our body naturally produces glutathione , however many have less than optimal glutathione levels due to stress, infection (HIV and Hepatitis C), poor diet, lack of sleep, and exposure to toxins and xenobiotics (statins, hormonal contraceptives, analgesics).
Deficiencies in glutathione leave the body vulnerable to toxins and inflammation—making the body weak and robbing one of high performance. Worst of all, low glutathione levels are linked to diseases including: autism1, atherosclerosis, coronary artery disease2, Alzheimer's disease3, Crohn's disease4, leukemia5, inflammatory bowel disease6, celiac disease7, osteoarthritis8 and chronic fatigue syndrome9.
Despite differing in biochemical pathways, these diseases are facilitated by high levels of oxidative stress. Oxidative stress is an imbalance between free radicals and antioxidant defenses and is a primary cause of cellular damage leading to disease.10 Throughout a life span, one is constantly exposed to free radicals through strenuous work, environmental toxin exposure, diet, and autoimmune disorder. Even something as essential as oxygen can be toxic under certain conditions, and this phenomenon is called the oxygen paradox.11
There is good news however. We can take an active role in preventing disease by increasing our antioxidant capacity. Antioxidants protect the cell from free radicals by accepting their unpaired electrons, thereby quenching the free radical's reactivity. Reducing free radicals protects the cell from oxidative damage and, ultimately, facilitates disease prevention. A large body of literature supports the notion that dietary antioxidants play an important role in preventing many human diseases.11
Glutathione is called the "master antioxidant" by some and for good reason. As antioxidant, its primary functions include:
Glutathione has many other responsibilities in addition to antioxidant function, including metabolism and cellular regulation, which will not be included here. For comprehensive reviews see sources 12 and 13.
By quenching free radicals, glutathione facilitates a decrease in oxidative stress at the cellular level. At the organismal levels, the effects are manifest as: increased energy, better sleep quality exercise recovery, and blood circulation15, mental clarity, less inflammation, and slower aging. Additionally, glutathione recycles other antioxidants and antioxidant enzymes including vitamin C, E, lipoic acid, CoQ10, super oxide dismutase, and catalase.11
So how do we optimize our glutathione levels?
The most obvious way to increase glutathione is through direct supplementation. However taking an oral supplement is ineffective, as it denatures in the stomach before it has pharmacological effects. Intravenous glutathione is an option, however I would consult your physician before taking further action. Another option for direct supplementation is liposomal glutathione, that is, glutathione encapsulated in tiny fat cells. I have no idea if this actually works, but I am willing to give it a try.
Other practical ways to optimize your glutathione levels include:
A German study demonstrated increased glutathione levels and related biomarkers in the blood of swimmers who swam at least once per week in ice-cold water for 5-10 minutes. I plan on testing this in the future.
Glutathione is synthesized from its precursor amino acids cysteine, glutamic acid, and glycine and undenatured whey has these glutathione precursors. I supplement Proserum Grass-Fed Whey Protein Concentrate as it is the cleanest sourced protein I could find on the market. Also, I stir my protein into solution using warm water. I do not blend as doing so breaks-up the protein reducing its quality.
Cysteine is the limiting amino acid in glutathione synthesis, thus increasing its precursor stimulates cysteine uptake by the cells and increases intracellular glutathione production.12 N-acetylcysteine is a stable and effective source to supplement glutathione synthesis.11 I have started supplementing 200mg daily with lunch.
Although it is one of three building blocks for glutathione synthesis, glutamate is actually broken down in the small intestine, thus supplementing the amino acid is ineffective for those looking to increase their glutathione levels. However, the amino acid glutamine is hydrolyzed to glutamate by the enzyme glutaminase, and the ketone alapha-ketoglutarate produces glutamine from branched chain amino acids— readily supplying glutaminase ingredients to produce glutamate and, ultimately, glutathione.11
The amino acid glycine can be directly supplemented, and has been shown to increase glutathione concentration in the liver cells of protein-deficient mice.11
Methionine is another amino acid one can supplement, as it is not synthesized by the body and can only be supplied through diet. This amino acid reacts with the enzyme gamma-glutamylcysteine synthase in liver cells to produce cysteine.12
Doing so gives the body another way to produce cysteine for glutathione production, as this antioxidant reduces the amino acid cystine to cysteine.17 In the past I have taken 200mg supplements with lunch.
Dietary selenium supports glutathione peroxidase which is an important enzyme for recycling glutathione.17A dietary deficiency of selenium has been shown to decrease tissue glutathione peroxidase activity by 90% leading to peroxidative damage and mitochondrial dysfunction.11 One can increase their selenium by simply supplementing 100mcg with a meal (I haven't taken this supplement before so I cannot speak to its effects) or eat foods rich in selenium such as grass-fed beef and wild-caught oysters.
A deficiency in dietary magnesium reduces glutathione reductase, another enzyme responsible for recycling glutathione. Magnesium is a cofactor for two pentose-cycle enzymes that catalyze the production of Nicotinamide adenine dinucleotide phosphate (NADPH) and its oxidized form NADP+. 12 The oxidation NADPH gives a proton to glutathione reductase so it can help recycle glutathione. In short, magnesium facilitates the recycling of glutathione. Supplement 600 to 800mg per day of magnesium malate, citrate, or aspartate, but be careful as too much can lead to diarrhea. The best time to take magnesium is in the evening since it confers relaxing effects.
Mineral elements like sulfur are available to us exclusively through dietary protein, yet only 2 of the 20 amino acids normally present in protein contain sulfur, and these include cysteine and methionine. Proteins contain between 3 and 6% sulfur amino acids and as stated earlier, cysteine is the limiting amino acid in glutathione synthesis and methionine facilitates cysteine production, neither of which are stored in the body.18 Thus we can increase our glutathione supply by eating food rich with these proteins. These include grass-fed beef, pork, lamb, or chicken. Wild caught and low mercury sea food is another good choice— salmon, king crab, and shrimp to name a few. Other sources include: soft-boiled eggs (so the protein and fats don't go rancid from overheating), onions, garlic, broccoli, and red pepper.
Glutathione is one of the most powerful antioxidants that can improve our health and performance by helping our bodies run better, giving us more energy, decreasing inflammation from oxidative stress, and ultimately reducing our risk for disease.
MMF is proven to help the body increase its glutathione levels.
MMF is the most powerful antioxidant supplement available. Patented. Proven.
Optomizing Glutathione for Health and Human Performance
Optomizing Glutathione for Health and Human Performance


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Joined: 22 May 2010
Posts: 12
Posted: Oct Sat 25, 2014 10:55 am
Post subject: Red Hot Genies at Harrah's-breaking news
We stayed a week in LV and flew to Reno last Saturday morning on the 10AM flight which was more than half empty. Took the CC shuttle to a $56 Saturday room at CC in the sky tower which we thought was great. Ate our first Awful Awful with vanilla shakes. Wandered through downtown.
Saturday morning we checked out at noon, wheeled our carry-ons down to Harrah's and checked in no problems. Spent 45 minutes looking through every cubbyhole in the Harrah's Reno maze for the Red Hot Genies, asked a cocktail girl who informed us that they are permanently GONE. She said many people are asking for them. Later, when I hit a $350 quarter Blazing Seven progressive, a tall Asian manager came to authorize the payout and he confirmed the Genies are gone permanently.
We paid $25 a night for 2 nights at Harrah's with a $20 food credit which we used at the totally fantastic steakhouse. So the total cost was $15 a night with NO resort fee which I think is cutting it as close to the bone as you can get. I advise checking Harrah's Reno rates if you are going to Reno without a room comp. They have a big place to fill and their midweek prices are cheap as dirt.
Went to Sterling buffet at the SL for Sunday champagne brunch for $35 which we found the highest quality. I had six lamb chops!
Took a quick bus trip to Pmill and the Lost Continent. I may be one of the few who is disappointed with the "de-Neoning" at the Pmill.
Tuesday morning had a second Awful Awful at 11AM with chocolate shakes this time before we took the noon shuttle at Harrah's back to the airport for the long flight east.
We hit a $1500 plus
Blazing Seven dollar progressive at the SL, the $375 quarter Blazing Seven at Harrah's and $200 on 3 rams at the 90 cent penny Nevadan progressive at the Cal-Neva. Otherwise we took a bath but ended up ahead $500 not including food.
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Joined: 03 Mar 2009
Posts: 425
Posted: Oct Tue 28, 2014 5:58 pm
Post subject:
Dang, sorry to hear the Genies are gone - I never even got to play them!!! Harrah's often does that with fun machines, but those cheap yet decent rooms keep pulling me back.
Speaking of, The Dog and I hit Harrah's Southern California (formerly Harrah's Rincon) - absolutely lost our asses there, but the property was nice. No free cocktails, supposedly per California law or some such shit. Not that free cocktails would have made us feel any better about the ass-beating though...
We'll probably shoot for a Reno run come spring as we're now relocating to San Diego at Christmas!!!
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Joined: 25 Dec 2005
Posts: 619
Posted: Nov Sat 01, 2014 7:23 pm
Post subject:
Hi melbedewy,
Congrats on all of your Blazing Sevens (and Rams!) hits, and thanks for the heads up regarding the Red Hot Genies...they'll be missed for sure. Glad I got the opportunity to get at least one progressive jackpot off of them during my time there.
I hadn't heard of the de-neoning of the Peppermill, but if that's the case, add me to the "disappointed" group!
Lily - great seeing you and congrats on the relocation!
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Joined: 12 Oct 2012
Posts: 497
Posted: Nov Sat 01, 2014 7:49 pm
Post subject: de-Neoning
I made the tour down Virginia Last sunday and stopped at the
Peppermill, My take on it was they have really cleaned and opened
up the casino. Some of the neoning is gone, not near as
gaudie, as it was. I think some of the Mirrors are gone also,
which opens it up so you can tell where your at.
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BC Dave
Site Admin
Joined: 18 Dec 2005
Posts: 1481
Posted: Nov Sun 02, 2014 7:40 am
Post subject: Where does all that neon go?
I speak for majority of long term Peppermill fans when I say,"
Bring back our neon!
I suppose it was expensive to take down all that neon and it would be a lot more expensive to re-neonize it, but that crazy glitzy neon is what gave the Peppermill it's unique identity -and people liked it! The Peppermill seems to be trying to reinvent itself al la Ceasers palace. And that motif has been over-done. Who really needs to feel they're gambling with Roman Emporers or with Zeus and Aphrodite watching over them? To be fair, there's still some neon - just done in a more subtle way.
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Joined: 18 Dec 2005
Posts: 955
Posted: Nov Sun 02, 2014 3:40 pm
Post subject:
Hey! I see SNOW in the hills on the web cams.
Looks chilly too.
Don;t anyone tell Florida/Nevada/Colorado Snowboarder
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Global athletic brand Adidas plans to stop using first-run or "virgin" plastic in its products by 2024. The company says by then, it will use only recycled plastic. The story was first reported by the Financial Times.
The company says it will also stop using virgin plastic in its offices, retail stores, warehouses and distribution centers. The decision is expected to save forty tons of plastic per year and is expected to go into effect this year.
The decision to remove plastic from its product lineup will also include polyester. Polyester is a synthetic material used in all types of athletic garments including t-shirts, athletic shorts and sports bras. It's lightweight, dries quickly and is also an inexpensive substitute for cotton.
The German sportswear company is the latest global brand to institute a plastic ban plastic in its operations.
Last month IKEA pledged to become climate positive by 2030. In order to achieve the goal, the Swedish furniture manufacturer will remove all single-use plastic products from its stores by 2020. That includes cups, utensils, straws, beverage stirrers and similar items.
"Our ambition is to become people and planet positive by 2030 while growing the IKEA business. Through our size and reach we have the opportunity to inspire and enable more than one billion people to live better lives, within the limits of the planet" said Inter IKEA Group CEO Torbjörn Lööf in a statement.
The company also plans to reduce its climate footprint by an average of 70% per product and achieve zero emissions home deliveries by 2025.
And last week, global coffee giant Starbucks announced it will be phasing out plastic straws from its more than 28,000 stores worldwide by 2020. In place of straws, the company will be bringing into use a lid with a teardrop-shaped opening about the size of a thumbprint.
Starbucks goes through more than 1 billion plastic straws a year, according to the company, because of the surge in popularity of its cold-temperature drinks. The move is in response to demand from both partners and customers.
"This move is an answer to our own partners about what we can do to reduce the need for straws," said Colleen Chapman, vice president of Starbucks global social impact overseeing sustainability.
"Not using a straw is the best thing we can do for the environment," she added.
Photo by pixabay.com


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"You can't buy chemistry."
No, not the science of matter. I'm pretty sure you can buy that, or at least enough materials to make it look like you're a chemist.
This refers to team chemistry, that elusive, impossible-to-engineer science of sports teams and how players fit together.
There are two groups of people that make the above statement. The first group consists of those that utter it genuinely, in the belief that chemistry is an invaluable factor in a team's success.
The second is made up of the people that say it snidely, often with a smirk or curled lip involved in some way.
These are the ones that would rather buy expensive free agents than develop prospects, the ones that completely discount chemistry as being simply a tool for winning.
No one argues that chemistry exists. The main question is, does it help you win? The answer? A definitive yes.
Take the Golden State Warriors. Coming off of one of the greatest seasons in franchise history, in which they won an NBA title, the Warriors came back this season and won 73 games, the most by any NBA team in any regular season, all the while with an easy, we might as well air to them.
Now, the Warriors are rolling through the playoffs, even with an injury to Steph Curry, their best player and the soon-to-be-repeat MVP.
Watching the Warriors, as I have all season, a few clues to their success become evident. First and foremost, they are really, really good.
The talent levels, both individually and as a team, are off the charts. Obviously without this level of talent, they probably would not have been able to accomplish what they have.
But this team has not become great off of talent alone: they have two other assets that have helped. This team loves to play basketball, and they love to play basketball with each other.
Scouts have called their chemistry "clockwork." Warriors forward Andre Iguodala calls it "the flow." On screen, what it looks like is pure joy. Forward Draymond Green passing dishing an assist to Curry, then smiling like it was he who just made the basket. Iguodala giving a half-shrug and smile after a Klay Thompson three-pointer.
These guys truly play for each other, and push themselves to do better, not because it looks good for them, but because they feel they owe it to their teammates, their friends.
Of course, not every team can have Warrior chemistry. For an example of what poor chemistry can do, I'll go from the NBA's best team to one of its worst: the Los Angeles Lakers. Granted, the Lakers weren't supposed to be the greatest team ever this year: a panel of NBA experts on cbssports.com had them sitting at around 27 wins before the season started. However, several team chemistry blow ups occurred over the course of this season, the most notorious of which being rookie D'Angelo Russell's recording of his teammate's admission to infidelity. The result?
The Lakers came in at 17 wins on the season, the worst record in Lakers franchise history.
Not all teams with great chemistry win championships, and not all teams with poor chemistry are awful–I'm looking at you, 2014 Dodgers.
But it certainly helps to play with people you feel you owe your best to.
So, athletes: get to know your teammates. Find out what they're all about. And play every game not for yourself, but for them.
You will perform better, both on your own and as a team.
And who knows? You might even have a bit more fun.
The Warriors sure do.


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Bundesliga Match Preview: Eintracht Braunschweig vs. Hannover 96
Match Date: 06 April 2014 (local time)
Venue: Eintracht Stadion
Braunschweig's even steven finish against Bayer Leverkusen sparked some survival hopes for this season. It has managed to maintain a good form during its last 6 matches and certainly, the above-mentioned draw gave a much needed moral boost for the club.
Indeed, the draw with Bayer was an unexpected one. The result can be fairly considered as one of the biggest upsets in Bundesliga. Not only did it out the minnow into the limelight, it also triggered talks about Sami Hyypia's impending sacking.
Mathematically speaking, Braunschweig can still make it to the next season. Its current form brags 4 draws, a loss and a stunning win against Mainz 05. Apparently, this is much better than what Hannover 96 has to offer. The latter has been bogged down by consecutive defeats that make them a possible relegation target.
To note, Hannover has already incurred 3 consecutive defeats. In those losses, it is also noticeable that they it has conceded an average of 2 goals.
Given the fact that Braunschweig will be playing in its own soil, it can readily exploit its home court advantage to turn the odds into its favor. However, it cannot afford to simply rest on its laurels.
Hannover is also determined to keep its Bundesliga status and will fight all the way to avoid the relegation. But granted that Braunschweig nails another upset, their journey to the safety zone will also need a helping hand. This meant that clubs which are scheduled to meet rock bottom squads must ensure their victory. Otherwise, Braunschweig's triumphs will become useless. Or maybe they are not really insignificant. Instead, they are just a little bit too late.
Prediction: A Stalemate
With both clubs trying to ensure their survival, a draw is most likely to occur in the said match. The even steven finish is pegged at decent value of 3.23 in the sports betting site, 12BET.
Image Source: Continental


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Flights to Wellington, the third largest city in New Zealand, are rarely anything approaching cheap, due to the enormous distance involved. However, if you are as flexible as possible with when you go and the route you take, you may be able to take advantage of a very reasonable deal. The airplane has to stop once along the way and there are many options.
Qantas.com, home to the national carrier of Australia, has flights from from London Heathrow direct to Wellington, stopping for a few hours along the way for the plane to refuel. Prices for a return ticket start at £980 if you take advantage of their special offers. Prices can be considerably higher if you are not as flexible as possible with your travelling times.
Air New Zealand offer some similar prices as well, often having some of the best rates for flights to Wellington. You can find out more about their ticket prices and special offers at their European portal, airnewzealand.eu. Prices for a return economy ticket start at £945, if you take advantage of one of their frequent special offers. Again, you will have to be as flexible as possible to take advantage of such a deal.
Other sites such as opodo.com or skyscanner.com are sometimes useful for finding the best deals on flights around the world. They compare ticket prices from all of the airlines connecting to Wellington. This allows you to find the best deal although, in some cases, the information is outdated.


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Residential and industrial installations
The decades of experience gained in both the residential and industrial construction of plants makes IDEAS4LIFE the benchmark for installation in private homes or public places, as well as for equipment intended for industrial, craft and trade. Both residential and industrial plants that is IDEAS4LIFE are electrical, air-conditioning, home automation and home control, audio-video and home theater, lighting, intrusion and video surveillance.
The experience has accumulated succeeding, over time, to satisfy the needs of customers increasingly sought innovative and evolving both in terms of knowledge that in terms of working practice in situations and types of systems very complex and elaborate.


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Skeletal Class II and III
Some times the jaw has not grown enough and is in a retruded position (Class II). In some cases it may be associated to obstructive sleep apnea and it can be corrected by an advancement of the maxilla and mandible to increase the airway.
The opposite (Class III or prognathism) may be due to excessive growth of the mandible, to a deficit in the maxillary growth or a combination of both. In this case the jaw is in a more forward position. This malocclusion may cause a temporomandibular joint disorder.
Long face
If the jaws grow too much in the vertical plane, an imbalance occurs in the lower third facial compared to the rest of the face.
Short face
When growth is insufficient translates into a squarer face and teeth are usually not seen.
Gummy smile
A vertical maxillary excess produces an excessive gum exposure that increases when they smile. We can treat it by performing surgery to reduce the vertical maxillary excess and enhance your smile.
Open bite
It occurs when the teeth do not contact. It is more common in the incisors and may be related to a lingual habit. It can be corrected by surgery in which we segment the maxilla to occlude properly with the jaw.
When the palate is narrow it causes a malocclusion between the teeth of the maxilla and the mandible and also becomes apparent when the patient smiles. By SARPE (Surgically Assisted Rapid Palatal Expansion) we can normalize the bite in cases where the discrepancy can not be corrected only with orthodontic treatment.
Facial asymmetry
If one side of the jaw has grown more than the other a deviation occurs in the chin and teeth do not occlude properly. Orthognathic surgery not only improves occlusion, but also achieves facial symmetry.
The profile and symmetry of the face can be altered by a prominent, deficient or deviated chin. Through a mentoplasty we can narrow the chin of a woman with a prominent chin or improve the profile of a patient with a retruded mandible.
Surgery First
In some patients orthognathic surgery can be performed first and posteriorly is done the orthodontic treatment. This new protocol reduces the total treatment time and gets a much faster functional and aesthetic result.
Maxillomandibular Advancement
Maxillary Advancement
Bimaxillary Surgery
Maxillofacial Surgery
Orthognathic Surgery
Dental Implants
Privacy Policy | Cookies Policy
Facial Aesthetic
Dr. Josep Rubio
GNATION Centro de Cirugía Maxilofacial
Casanova 101, pral. 1ª
08011 - Barcelona
Tel. +34 93 453 79 65 Fax +34 93 451 44 80
Passeig de Sant Joan de Déu, 2, 08950 Esplugues de Llobregat, Barcelona, España
Tel. 93 600 97 83 Fax. 93 600 97 84


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As summer swings into full gear, many of you may be counting the days till vacation starts. However running a successful business demands full time (24/7) commitment, and stepping away from the office for an extended time can be intimidating. Our newest Automated Push Notification with Cart Reminder comes at just the right time. You can set the campaign on autopilot before heading out of office, and the eCommerce sales will continue to rolling in! This month, we are excited to introduce the Automated Push Notification with Cart Reminder along with another highly requested feature, 2 Step Verification. What is Automated Push
9 Super Awesome Ho Ho Holiday Marketing Ideas
Everyone loves a surprise. That's why we are offering 9 unconventional and super awesome holiday marketing ideas for eCommerce so you get prepared for your Holiday Marketing campaign and hopefully, put a smile on your customer's face! Who knows, those holiday marketing campaign ideas might even surprise you in the form of year revenue results! The surprise factor is the game-changer Christmas brings some of the year's most welcome surprises. According to the Harvard Business Review, a surprise is like crack for your brain. It changes behavior, intensifies relationships, and strengthens emotions. Because the human mind remembers novelty better than predictability,
Top 5 Black Friday Marketing Automation Scenarios for Holiday Success
When Black Friday rolls around, retailers have a lot to get excited about. According to a study last year, over 137 million Americans plan to shop over Thanksgiving weekend. That can translate into huge traffic and sales for retailers across the country. It is by far the biggest retail day/event of the year. This means that brands and marketers should be planning well in advance to take advantage of this big date. One aspect of the preparation involves setting up the right campaigns, workflows, and tools to maximize sales from the holiday traffic. In a previous post, we covered the step
8 Facts About Ecommerce Marketing Automation That Will Make You Think Twice
Marketing automation usually refers to a platform with associated tools and analytics to help develop a lead nurturing strategy. In short, it enables you to automate your marketing so you can shift your energy to more cerebral tasks and strategic thinking. It can be a super valuable tool for nurturing prospects since the relevant and personalized content helps convert these prospects into leads and then customers. More companies are realizing the power of marketing automation for e-commerce, whether selling event tickets, services or products online. Marketing automation can range from email marketing to lead management and everything in between. Check


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The Nerd
By Jana J. Monji
Larry Shue's The Nerd is one of the few theatrical pieces in which a theater critic is the hero. He's suave, he's witty and although he doesn't get the girl, we're not even sure he wanted her. But he is not, of course, the eponymous twit.
The twit part, Rick Steadman, is played by French Stewart. If you've seen Stewart as Harry Solomon on Third Rock from the Sun, you know he's had practice playing a doofus, and does it well. In Burbank's Colony Theatre Company production of The Nerd he's lost the sweetness and innocence of Harry Solomon. This nerd is annoying in a scratching on the chalkboard way.
In case you're not familiar with this often produced play, Steadman saved Willum Cubbert (Ed. F. Martin) when he was wounded in Vietnam. Cubbert was unconscious and never saw the face of his saviour, but he and Steadman wrote to each other after they were both home in the States. Cubbert promised Steadman his undying gratitude but did not count on him arriving and turning into the nightmare guest who never leaves. That arrival coincides with Cubbert's birthday for which his sometime girlfriend Tansy (Faith Coley Salie) has fixed up massive quantities of food. Also present to witness Steadman embarassing Cubbert are Warnock Waldgrave (Jonathan Palmer), his wife Clelia (Cindy Warden), their bratty son (Justin M. Bretter) and, to lighten up the proceedings, theater critic and professional sarcastic wit, Axel (Kevin Symons).
Director David Rose emphasizes Stewart's role, but comedically he isn't the only one carrying the show. Warden is priceless as the suppressed, homely wife in a dowdy and shapeless pastel plaid skirt and patterned sweater. Each contortion of her face and body is hilarious. Palmer blusters and roars impatiently as the rigid, commanding businessman with no time to waste and no sense of humor, but can't possibly upstage Warden. Ed Martin, who played Charlie Brown in the Colony's recent staging of You're a Good Man, Charlie Brown, is again the sad sack who finally explodes. His Cubbert is sympathetic but there is a lack of fireworks between him and Faith Salie's Tansy. We just have to believe Axel the suave, critical mover's word for it that they are meant for each other.
If you wince at the thought of investing your sympathies in an unlovable nerd, who might be mentally challenged as the butt of this one joke play, don't worry. There's a twist on the way to a happy ending. The Nerd is an extended joke with nothing deep about friendship or self-sacrifice here. Inn this production, however, it's a joke that's well told.
At This Theater
Leonard Maltin's 2003 Movie and Video Guide
Ridiculous!The Theatrical Life & Times of Charles Ludlam
Somewhere For Me, a Biography of Richard Rodgers
The New York Times Book of Broadway: On the Aisle for the Unforgettable Plays of the Last Century
6, 500 Comparative Phrases including 800 Shakespearean Metaphors by CurtainUp's editor.
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Go here for details and larger image.


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In 1989 , along with Bob Toski , PGA, we built the Toski -Battersby Golf Learning Center in Coconut Creek, Fl. Just north of Fort Lauderdale. We have an 18 acre green grass learning center teaching all levels of golfers . I am a PGA class A member since 1987 and am 55 years of age.
Read more about this pro
Kevin was very upbeat and made my lessons fun He even helped my Mom , a golfer already With some tips to help her game. I took 4 lessons at the driving range and putting green and the next 2 were on the course playing. I would recommend him to anyone wanting to learn the game.
Kevin is easy going, friendly and an excellent instructor. Makes learning the game of golf fun.
My first look is at my students grip and physical characteristics so they are in line with the shot they desire within swing fundamentals whom I've acquired working with Bob Toski over 40 years
I am a 25 year class A PGA professional of the USA in good standing
I discount my prices for this forum up to 25 to 30 percent off my website prices
As a junior golfer at -14 I have worked with Bob Toski , PGA hall of fame . We built our center in Coconut Creek in 1989.
I have worked with seniors juniors and collegiate players who have gone on to professional golf tours .
I have four autistic juniors of differing degrees and found much fulfillment as they have in an endeavor that doesn't require a team and they can progress without judgement
I would check credentials like PGA certified and also website and playing and teaching background . Mine is battersbygolf.com.
What kind of program can be designed economically to get the most instruction at a rate that is reasonable .


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Make Appointment or call 03 9877 2035
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|Braces are something that has been dreaded by most people since they started going to the dentist when they were young. While most people want to have nice, straight teeth, they do not want to endure years of braces and irritation to have them. Traditional braces, which are typically a metal frame and metal brackets that go on the outside of the teeth are what most people choose when having to get their teeth corrected.
With advancements in the orthodontic field, traditional braces are not made with the same bulky materials they used to be made with. The traditional braces option now includes sleeker frames and brackets that are less likely to irritate. Our trained orthodontic staff here at New England Orthodontic Specialists can give you a consultation to find out more information and to be fitted for traditional braces.
What to Expect from Traditional Braces
While as uncomfortable as traditional braces, or metal braces sound, the technology and different things used to prevent irritation make them a comfortable option. The process begins by our orthodontist taking a mold of your mouth so that you can understand how to set up your traditional braces. After that, you will usually come back for another visit where they will begin the process of actually putting the braces on your teeth.
This process will typically take one to two hours to complete, and then we will go over how to properly care for your new braces. After that you will experience mild pain and gum irritation for a few days, then you will begin to be used to it. Most people will have braces on for six months to several years to correct whatever teeth and jaw problem they might have. While the length of time wearing them is long, and they can be costly, correcting your teeth is about more than looks. It can create better oral health and can raise self-confidence in any person struggling with their smile.
How are Traditional Braces Removed
The removal of any kind of braces, especially traditional metal frame braces, is not always the easiest task. Care and precautions must be taken when removing braces, so the teeth do not get damaged. The bond between the brackets and the teeth is so strong that it allows the teeth to shift into the correct alignment. Usually what holds the brackets to the teeth is strong adhesive or glue.
To remove the bracket, it is squeezed at the base and essentially pops off, leaving the glue still on the teeth. After this, our orthodontists will remove the glue from the teeth and complete the removal process. This is the preferred method of our orthodontists because it ensures that the enamel is still intact with the tooth. Often a permanent retainer is put behind the teeth which helps keep the teeth from shifting back into its original position. You would not want your teeth shifting after months of wearing braces to have the smile you have been waiting for.
To schedule an appointment to correct your teeth with traditional braces, call New England Orthodontic Specialists at (978) 529-3030 today!


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November 2015 CIPS Volunteer of the Month:
Shaun Herron I.S.P., ITCP
President, CIPS Saskatchewan
About Shaun:
What is your Background?
I started in the computer industry in 1989 with a small company called Education Services which over time has evolved into ESTI Consulting Services. As the first employee at a small firm that is nearing 30 years in operation it has been an interesting experience to see the company though that evolution.
I have a Bachelor of Education degree and a number of industry certifications such as MCSE, MCSE+I, ITIL Foundations, Certified Computing Professional (CCP), Project Management Professional (PMP), TOGAF, and PROSCI. In my current role I perform Client Relationship Management, Project Management, and Technical System Management.
What type of Involvement have you had with CIPS?
I first joined CIPS in 2005 along with obtaining by I.S.P. designation. I have served on the CIPS Saskatchewan Board for the past two years first as a Director and then as Vice-President. Prior to joining the board I participated on a Committee that helped to promote CIPS and new I.S.P. designates.
What value has your involvement with CIPS provided?
I joined CIPS to solidify my career as a Professional in the Information Technology field. It was important for me to obtain my I.S.P. and become a member of a professional organization specific to IT. CIPS has provided me with a number of benefits including professional development opportunities, volunteer opportunities, and networking.
There is no doubt in my mind that there is an important role for CIPS to play in the years ahead in terms of developing, promoting and supporting IT professionals.


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301 W. Heritage, Ste. 5 Tyler, TX 75703
Trust your permanent cosmetics to the hands of experience and education!
301 W. Heritage, Ste. 5 Tyler, TX 75703
Trust your permanent cosmetics to the hands of experience and education!
At Tyler Permanent Cosmetics you can rest assured that you will get the brows that fit YOUR face and the color that compliments your skin tone!
Hairstroke/Microbladed brows are a series of tiny little lines that simulate eyebrow hair.
There are many shapes, thickness' and colors for the permanent eyeliner. When you come for your appointment, we will discuss your wishes and address your concerns before we ever begin the procedure.
These prices are for 'first time' services on skin that has never had permanent cosmetics. Please note that as of 12/1/2019 there will be a price increase on the services. This is very hard for me to do and has been in the works for a long time.
Follow Up (if needed) 75
Follow up (if Needed) 75
Follow up (if needed) 75
Follow Up (if needed) 200
Follow up ( if needed) 150
Follow up (if needed) 75
Follow up is included with the eyeliner follow up
A Color refresh or Color boot is a service that is on Permanent Cosmetics 12 months or older.
Follow Up (If Needed) 75
Follow Up (If Needed) 75
Follow Up (If Needed) 75
In some cases where the tissue is saturated with old pigment, removal will be needed. A consultation is required to determine this.
Follow Up (If needed) 75
Follow Up (If Needed) 200
Follow Up (If Needed) 200
Add a footnote if this applies to your business
When you are ready to schedule your appointment, we are here to assist you. When you have scheduled your appointment, that time is set aside for only you. There is a nonrefundable booking fee for appointments that are made but not kept. The fee will be deducted from the cost of your service.
The booking fee for 'first time services' is $100. For Color refresh appointments, $75. For follow up Appointments $40.
If you are a 'first time' client to Tyler Permanent Cosmetics, you are required to arrive 15 minutes before your appointment to fill out the intake paperwork. If you are scheduled at 1:00pm, you need to be here at 12:45. If you show up at 1:00 and still need to fill out paperwork, you are late. Late arrivals will have to be rescheduled and the booking fee will be forfeited.
If you are coming from out of town, traffic is ALWAYS bad on Broadway, so please plan accordingly and give yourself some extra time.
We understand that unforeseen circumstances may arise that could force your to reschedule your appointment. Please understand that such changes affect, not only your technician, but also the clients that have appointments after yours.
If you NO SHOW your initial appointment, your booking fee is forfeited and you will have to pay for your procedure before being put back on the schedule.
If you NO SHOW your Follow Up or Color Refresh appointment, you will forfeit your booking fee and the cost of your service will be paid before putting you back on the schedule.
There are many reasons a client may need a follow up appointment. For each client we have, there is a different skin type, medical history, physical/athletic habits, sun exposure, skin care products etc. About 20% of our clients will need a follow up appointment. At the end of your appointment, you will be given an after care paper and your follow up date written on it. It is important that, if you need a follow up, you schedule your appointment with in those dates. Just know that we usually stay booked a couple weeks out, so you cannot call the day,or a couple days before your deadline and expect to get in with in your window of time.
A color refresh is a service that Tyler Permanent Cosmetics has originally done and is 12 months post the original service. We keep notes in your file that include, color, skin type, medical history as well as, the date of your last procedure. If you are not a previous client of Tyler Permanent Cosmetics, you probably will need a consultation to determine out plan of action.
NOTE: All permanent cosmetics fade! Some pigments are better than others and will last longer, but eventually, they too will fade. The sun is a big reason, skin care products, tanning beds, overall general health, and medications to name a few reasons. Pigments have improved over the years and the dramatic color changes are not as bad as they used to be.
301 W Heritage Dr, Ste. 5, Tyler, Texas 75703, United States
Tues- Fri: 9am - 6pm
Some Monday's
2nd and 4th Saturday


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In addition to Z1015, Kodak announced also the EasyShare M1093 IS digital camera. EasyShare M1093 IS features 10 Megapixel sensor, 3x optical zoom, image stabilization, ISO up to 3200 and a 3-inch LCD display.
The M1093 is able to capture HD pictures and videos. It comes with also the Smart Capture feature that can identifies the scene and adjusts camera settings for a great picture in just about any environment – automatically.


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My return to country on second trip to Expo 70 went flawlessly. I arrived back in country on time and had plenty of time between arrival and departure to visit some of the places I had been to the first time I toured around Da Nang.
I took mental images of pictures I wanted to take, knew enough about the camera to properly focus the lens, keep the shutter above 125th of a second and adjust the F-Stop so that the needle was exactly in the middle of the gap on the right side of the viewing screen.
I also knew Ektachrome was what the Public Affairs Office of the 101st Airborne Division (Air Mobile) wanted me to shoot. Had around 20 rolls of Ektachrome film and decided to use the polarizing filter like a religion.
By the time I got back on the C-130 and headed up to Camp Eagle, all but a few shots were left on roll 20. I used them up on landing at Phu Bie and arriving at Camp Eagle. I had just enough time to turn in the film over at the PX.
I counted 19 rolls. I had forgotten that one roll was back in the hooch and forgot where I put it.
So, I processed 19 rolls. Two days later, I processed the 19th roll over at the recreational services photo-lab.
My hear skipped a few beats. Not because the images were lousy but because the hand developed images looked so much better than I remembered what they looked like in real life.
A few day later, the images came back in from the PX. I payed for them and opened the slide boxes. They came out okay but didn't give me that feel of confidence the roll I developed myself did.
From that day on, I would develop my own rolls of color slide film over at the recreational services photo-lab and no where else.
After going through the slides, I narrowed down the images I wanted to show division PIO editors what I had and went over to them with the slides.
One of them gave me a ho hum look, put them up on the white Plexiglas table and started giving them a once over with a loop. I don't believe he he got passed the first one before calling his buddy over.
The first editor gave me this look that said without words, "Okay, who are you?"
The second editor, "Man, we need this one for a double truck."
He then turned and looked at me, "How took these pictures?"
"I did."
"I think you missed you calling!"
"Thank you, what's a double truck?"
"A two page spread."
"We got a pack of 40 rolls in the refrigerator. It is a bit outdated. You have a refrigerator at the Battalion?"
"Good, take it. Bring two rolls back here per week. We'll process the film for you. You'll have to come in and write your name on the bottom of each slide."
"Do that with these and we'll use them," said the first editor. "Mark the location where the images were taken on the top. Here's some slide protectors. Once you mark your slides, place them into these. And be careful not to touch the film of the slides."
We put the slides back into the box and I grabbed the film out of the refrigerator and headed back over to battalion. After putting the film into our battalion refrigerator and started marking all my slides with my name on the bottom and the location on the top.
So, for the next 16 weeks, I took two rolls of film over to them, added the locations and my name on the bottom of each slide and gave them images that to this day I'm not sure what they did with them all.
In the mean time, between taking pictures for the division PIO and the task of taking Battalion Awards and Decorations ceremonies, I was pretty busy working on the articles I wanted to get published.


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Words kill, words give life; they're either poison or fruit—you choose. —Proverbs 18:21 (The Message)
Now that I have your attention, I will tell you that I know learning to make healthier choices is a lifetime process, not a 30-day transformation. But I can also tell you that if you need a jump start, using positive language can make a difference in your life in a short time. There is science behind affirmations just as there is science behind prayer—both improve your well-being. Here are 30 affirmations (including scripture ) that will change the way you think about your health if you use them every day. Pray them, think them, say them aloud.
Please let me know how these work for you. Also, share with us in the Comments section your favorite affirmations.
- I deserve relationships that are healthy.
- I count my positive attitude as a blessing; it helps me focus on the good in me.
- I am not alone. God is with me.
- Bless the Lord, O my soul, and do not forget all his benefits . . . who heals all your diseases, . . . who satisfies you with good as long as you live so that your youth is renewed like the eagle's. —Psalm 103:1-5
- I release to God my fear, doubts, and challenges. God returns to me a spirit of love, power, and a sound mind. I have peace and all is well.
- . . . I will heal them and reveal to them abundance of prosperity and security. —Jeremiah 33:6
- I eat five daily servings of fruits and vegetables. I choose leafy green vegetables and deep red and colorful fruits.
- I am creative. Each day I see beauty in what I do.
- I become stronger when I allow others to help me.
- [God] heals the brokenhearted, and binds up their wounds. —Psalm 147:3
- I do not let the negative words of others stop me from loving myself and reaching my goals.
- When I believe that things can change, then I can change them.
- For I will restore health to you, and your wounds I will heal, says the Lord, . . . —Jeremiah 30:17
- I do not carry my worries by myself. God is with me. I rest—renewed and restored by the love of God.
- I trust God for the highest good for my community, the world, and myself.
- I claim God's power for my life, which allows me to change the behaviors I can and surrender to God those things I cannot change. (Healing Action: Keep a food journal. List the foods you eat and how you feel after you eat them. Eat more of the energy foods.)
- I listen to the messages my body sends me.
- I believe my well-being is connected to the well-being of others.
- I know that prayer changes me and helps me live in peace.
- A cheerful disposition is good for your health; gloom and doom leave you bone-tired. —Proverbs 17:22 (The Message)
- I can trade a half hour of TV for a 20-minute walk around the block.
- I let go of trying to control others, and I live with more joy.
- I am created by God and am thankful for my special body.
- I say no to harmful behaviors and yes to the good life for myself.
- Heal me, Lord, and I will be healed; save me, and I will be saved, for you are the one I praise. —Jeremiah 17:14
- I go with the flow and save my energy. I move in harmony with my purpose.
- I seek divine guidance, listen for the answer, and learn to relax.
- I have health goals that are reasonable and right for me. I am willing to try new ways of living healthy.
- I find peace in prayer. I find joy in praise. I find wellness with a caring physician.
- Beloved, I pray that all may go well with you and that you may be in good health, just as it is well with your soul. —3 John 2 (Healing Action: Play soft music and sit in silence for 5 minutes. Breathe. Ask your spirit; ask your body, "What do you need to be well?" Listen.)
My Joys
- Each day I learn more about what brings me joy.
- I practice positive health messages.
- Reading scripture helps me start my day.


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Sale of Townhouse 492761 in Los Alcazares, Murcia
Google maps returned a status of REQUEST_DENIED
Price : €225,000 (£204,019)
Reference : 492761
Magnificent townhouse located in the residential Olivar de Roda. Fully furnished consists of 2 bedrooms 2 bathrooms and living room - kitchen. It also has a private garden, private terrace-solarium, air conditioning, kitchen with appliances and private pool. Located in a quiet area close to all services and shops, only 10 minutes from the beach with Roda golf course being a 5 minute walk, this property has excellent rental potential, the current owner is achieving 7000 euros between June and September through Air BNB, the property has a vacation license.
|Number of bedrooms
|Number of bathrooms
|Swimming Pool


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Mesotherapy is a non-surgical treatment that facilitates the infusion of regenerative and rejuvenating substances such as essential amino acids, vitamins, natural or homeopathic extracts, enzymes, etc. in the skin. These substances act on the epidermis, dermis and subcutaneous tissue. The individualized cocktail can be either injected with thin needles or administered by iontophoresis. If a suitable cocktail is selected for every patient and the procedure is repetead for several weeks, a dramatic improvement in moderate or severe wrinkles and creases can be achieved.
The method is indicated for wrinkles, dull and dry skin, localized refractory fat deposits, mild or moderate cellulite or as a "pre-event" single treatment.
In general, the procedure is simple, risk-free and totally painless in the no-needle technique. However, allergic reactions to some of the substances used may occur – which is why it is necessary to inform your doctor about your history prior to treatment. Ecchymosis, erythema or local edema can also be noted. All of these side effects are reversible and of short duration.
Schedule an appointment:
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In the first part of this tutorial, we programmed an algorithm that creates a three-dimensional randomized maze of single cells. Now we want to show this maze in our level. This tutorial is primarily about the simplest way of presenting the maze without any gameplay mechanics.
Tag Archives: unity 3d
Unity Tutorial 3D Maze Generator – Part 1
Sometimes you need a maze for your games or just a procedurally generated level. In Wikipedia you will find about "Maze Algorithm" some algorithms that are easy to implement. Now we would like to use the example of the "depth-first search algorithm" to create a 3D maze generator in Unity. That means, our maze should not only have ways in the two-dimensional plane, but ways may as well go up or down.