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Background. Side effects of antineoplastic agents (especially leukopenia and neutropenia) could be the main limiting factors for efficient treatment.
Objective. The research is aimed at the study of myeloprotective capability of biosimilars of granulocyte colony stimulating factor (G-CSF) and granular carbon oral adsorbent C2 in melphalan-induced bone marrow suppression in Guerin carcinoma-grafted rats.
Methods. Melphalan at the dose of 5.5 mg/kg was used to promote bone marrow suppression in the Guerin carcinoma grafted rats. To fight myelosuppression, we used filgrastim and its analogue, designed and produced by IEPOR, a recombinant granulocyte colony-stimulating factor (r-GCSF). Carbon granulated enterosorbent C2 was used for enteral sorption therapy (bulk density γ=0.18 g/cm3, diameter of granules 0.15-0.25 mm, BET pore surface – 2162 m2/g). All rats were sacrificed on the 17th day after carcinoma cells inoculation or on the 8th day after Melphalan injection.
Results. Alkylating cytostatic agent caused severe leukopenia (by 95.7%), neutropenia (by 73.9%), and thrombocytopenia (by 84.9%) in the experimental rats. Mortality rate was 57%. Filgrastim and enterosorption with carbon oral adsorbent C2 increased the studied indices, but the most prominent results were observed when combination of both factors was used. Studied means did not affect the anti-tumor efficacy of Melphalan alone and in combination.
Conclusions. Our results are perspective for further investigation of the efficacy of the combination of carbon oral adsorbents and hematopoietic cytokines in cases of ameliorate anti-cancer chemotherapy side effects, and its implementation into clinics.
Xing C, Liang B, Wu J, Yang Q, Hu G, Yan Y, et al. Prognostic significance of leukopenia during the induction phase in adult B cell acute lymphoblastic leukemia. Cancer Manag Res. 2018;10:625-35. doi: 10.2147/CMAR.S158359
Al-Ansari S, Zecha JAEM, Barasch A, de Lange J, Rozema FR, Raber-Durlacher JE. Oral Mucositis Induced By Anticancer Therapies. Curr Oral Heal Reports. 2015 Dec 19;2(4):202-11. doi: 10.1007/s40496-015-0069-4
Turgeman O, Medical R, Blumenfeld Z, Medical R. Minimizing the doxorubicin-Induced gonadotoxicity by sphingosine-1-phosphate analogue FTY720 Minimizing the doxorubicin-Induced gonadotoxicity by. Am J Clin Exp Obs Gynecol. 2015;2(1):24-33.
Wang Y, Probin V, Zhou D. Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy. Curr Cancer Ther Rev. 2006 Aug 1;2(3):271-9. doi: 10.2174/157339406777934717
Gaducci A, Gargini A, Palla E, Fanucchi A, Genazzani AR. Neutropenic Enterocolitis in an Advanced Epithelial Ovarian Cancer Patient Treated with Paclitaxel/Platinum-based Chemotherapy: A Case Report and Review of the Literature. Anticancer Res. 2005;(25):2509-14. Available from: https://pdfs.semanticscholar.org/e16b/eea03afd2a93686821eff80a60696893301f.pdf
Lalami Y, Klastersky J. Impact of chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) on cancer treatment outcomes: An overview about well-established and recently emerging clinical data. Crit Rev Oncol Hematol. 2017;120(June):163-79. doi: 10.1016/j.critrevonc.2017.11.005
Denduluri N, Patt DA, Wang Y, Bhor M, Li X, Favret AM, et al. Dose delays, dose reductions, and relative dose intensity in patients with cancer who received adjuvant or neoadjuvant chemotherapy in community oncology practices. JNCCN J Natl Compr Cancer Netw. 2015 Nov;13(11):1383-93. doi: 10.6004/jnccn.2015.0166
Santolaya ME, Alvarez AM, Avilés CL, Becker A, Mosso C, O'Ryan M, et al. Admission clinical and laboratory factors associated with death in children with cancer during a febrile neutropenic episode. Pediatr Infect Dis J. 2007 Sep;26(9):794-8. doi: 10.1097/INF.0b013e318124aa44
Bonadonna G, Moliterni A, Zambetti M, Daidone MG, Pilotti S, Gianni L, et al. 30 years' follow up of randomised studies of adjuvant CMF in operable breast cancer: cohort study. BMJ. 2005 Jan 29;330(7485):217. doi: 10.1136/bmj.38314.622095.8F
Barnes G, Pathak A, Schwartzberg L. Pharmacoeconomics of Granulocyte Colony-Stimulating Factor: A Critical Review. Adv Ther. 2014 Jul 3;31(7):683-95. doi: 10.1007/s12325-014-0133-9
Xie J, Cao J, Wang J, Zhang B, Zeng X, Zheng H, et al. Advantages with prophylactic PEG-rhG-CSF versus rhG-CSF in breast cancer patients receiving multiple cycles of myelosuppressive chemotherapy: an open-label, randomized, multicenter phase III study. Breast Cancer Res Treat. 2018 Apr 11;168(2):389-99. Available from: http://link.springer.com/10.1007/s10549-017-4609-6
Nikolaev VG. Sorption Therapy with the Use of Activated Carbons: Effects on Regeneration of Organs and Tissues. In: Hemoperfusion, Plasmaperfusion and Other Clinical Uses of General, Bio_specific, Immuno and Leucocyte Adsorbents. WSPC; 2017. p. 221-43. doi: 10.1142/9789814749084_0007
Nikolaev VG, Sakhno LA, Snezhkova EA, Sarnatskaya VV, Yushko LA. Carbon adsorbents in oncology: Achievements and perspectives. Exp Oncol. 2011;33(1):2-8.
Nikolaev VG, Samsonov VA. Analysis of medical use of carbon adsorbents in China and additional possibilities in this field achieved in Ukraine. Artif Cells, Nanomedicine, Biotechnol. 2014;42(1):1-5. doi: 10.3109/21691401.2013.856017
Muravskaya G V., Nikolaev VG, Sergeev VP, Krutilina NI, Bonatskaya L V., Klevtsov VN, et al. Enterosorption in Oncotherapy. Artif Cells, Blood Substitutes, Biotechnol. 1991;19(1):167-74. doi: 10.3109/10731199109117823
Shevchuk OO, Posokhova KA, Todor IN, Lukianova NY, Nikolaev VG, Chekhun VF. Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor. Exp Oncol. 2015;37(2):135-8. doi: 10.31768/2312-8852.2015.37(2):135-138
Shevchuk OO, Posokhova KA, Sidorenko AS, Bardakhivska KI, Maslenny VM, Yushko LA, et al. The influence of enterosorption on some haematological and biochemical indices of the normal rats after single injection of melphalan. Exp Oncol. 2014;36(2):94-100.
Liu W, Zhang C-C, Li K. Prognostic value of chemotherapy-induced leukopenia in small-cell lung cancer. Vol. 10, Cancer Biology & Medicine. Chinese Anti-Cancer Association; 2013. p. 92-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23882424
Held TK, Gundert-Remy U. Pharmacodynamic Effects of Haematopoietic Cytokines: The View of a Clinical Oncologist. Basic Clin Pharmacol Toxicol. 2010 Mar 1;106(3):210-4. doi: 10.1111/j.1742-7843.2009.00514.x
American Society of Clinical Oncology. Recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. J Clin Oncol. 1994 Nov;12(11):2471-508. doi: 10.1200/JCO.19126.96.36.1991
Lyman GH, Allcott K, Garcia J, Stryker S, Li Y, Reiner MT, et al. The effectiveness and safety of same-day versus next-day administration of long-acting granulocyte colony-stimulating factors for the prophylaxis of chemotherapy-induced neutropenia: a systematic review. Support Care Cancer. 2017 Aug 8;25(8):2619-29. doi: 10.1007/s00520-017-3703-y
Vial T, Descotes J. Clinical Toxicity of Cytokines Used as Haemopoietic Growth Factors. Drug Saf. 1995 Dec;13(6):371-406. doi: 10.2165/00002018-199513060-00006
Gavioli E, Abrams M. Prevention of granulocyte-colony stimulating factor (G-CSF) induced bone pain using double histamine blockade. Support Care Cancer. 2017 Mar 5;25(3):817-22. doi: 10.1007/s00520-016-3465-y
Khoury H, Adkins D, Brown R, Vij R, Westervelt P, Trinkaus K, et al. Adverse side-effects associated with G-CSF in patients with chronic myeloid leukemia undergoing allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant. 2000 Jun 5;25(11):1197-201. doi: 10.1038/sj.bmt.1702423
Mehta HM, Malandra M, Corey SJ. G-CSF and GM-CSF in Neutropenia. J Immunol. 2015 Aug 15;195(4):1341-9.
doi: 10.4049/jimmunol.1500861
Heslet L, Bay C, Nepper-Christensen S. Acute radiation syndrome (ARS) - treatment of the reduced host defense. Int J Gen Med. 2012;5:105-15. doi: 10.2147/IJGM.S22177
Sarnatskaya VV, Sakhno L, Paziuk LM, Yushko LA, Rodionova NK, Maslenniy VN, et al. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with Lewis lung carcinoma in mice. Exp Oncol. 2018 Mar;40(1):33-41. doi: 10.31768/2312-8852.2018.40(1):33-41
Mikhalovsky SV, Sandeman SR, Howell CA, Phillips GJ, Nikolaev VG. Biomedical Applications of Carbon Adsorbents. In: Novel Carbon Adsorbents. Elsevier; 2012. p. 639-69. doi: 10.1016/B978-0-08-097744-7.00021-1
Ponomariova OV, Pivniuk VM, Nosko MM, Sakhno LO, Dekhtiar TV, Nikolaev VG, et al. Prophylaxis with carbon enterosorbent of acute and delayed emetogenic toxicity of chemotherapy treatment in oncologic patients. Onkologia. 2008;10(3):370-3 [in Ukrainian]. Available from: http://dspace.nbuv.gov.ua/handle/123456789/11944
Sakhno LA, Yurchenko OV, Maslenniy VN, Bardakhivskaya KI, Nikolaeva VV, Ivanyuk AA, et al. Enterosorption as a method to decrease the systemic toxicity of cisplatin. Exp Oncol. 2013;35(1):45-52. Available from: http://dspace.nbuv.gov.ua/handle/123456789/13911
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In the 7 December 2018 Federal Register, the US Food and Drug Administration (FDA) announced the availability of its new draft guidance document entitled "Developing and Labeling In Vitro Companion Diagnostic Devices for a Specific Group or Class of Oncology Therapeutic Products." A link to the draft guidance document follows, (Developing and Labeling In Vitro)
Comments on the draft guidance are due by 5 February 2018.
The draft guidance document discusses factors relevant to the development and labeling, where appropriate, of companion diagnostics to support the indicated uses of a group or class of therapeutic cancer products, as opposed to just a specific product(s). It also discusses when such broader development and labeling may not be appropriate. According to FDA, the draft guidance document expands on existing Agency policy for broader labeling of companion diagnostics. Per existing policy, if evidence is sufficient to conclude that a companion diagnostic is appropriate for use with a specific group or class of therapeutic products, its intended use/indications for use can name the specific group or class rather than a specific product(s). FDA acknowledges that, in the past, trials designed to support approval of a specific therapeutic product and a specific companion diagnostic have led to narrower companion diagnostic labels that reference only a specific therapeutic product(s) as opposed to a product group or a class. Such narrow specificity in labeling can limit a potentially broader use of a companion diagnostic that may be scientifically appropriate, according to the Agency.
In addition to establishing a comment period for the draft guidance document, FDA is interested in feedback from interested parties on the following questions and issues:
- Please describe any specific challenges with developing the evidence needed to identify in labeling a companion diagnostic for use with a specific group or class of oncology therapeutic products, rather than a specific therapeutic product. For example, please describe any challenges resulting from industry or business practices, including business agreements. What actions can FDA take to address the challenge(s)?
- Please describe any specific challenges with submitting a premarket approval (PMA) supplement to FDA to expand the labeling for an approved companion diagnostic for use with a specific group or class of oncology therapeutic products. What actions can FDA take to address the challenge(s)?
- Please describe any additional actions FDA can take to facilitate or encourage broader, evidence-based labeling that supports the use of a specific group or class of oncology therapeutic products with a companion diagnostic.
- The guidance notes that variations in defined cut-points established for specific biomarkers for companion diagnostics can lead to challenges in implementing broader labeling for a specific group or class of oncology therapeutic products. Are there actions that FDA, or the broader scientific community, can take to facilitate standardization in this area?"
Commenting on the draft guidance document and supplying feedback on FDA's four additional questions/issues provides an important opportunity for developers of companion diagnostics to express their views to FDA on these topics and to influence FDA's ultimate thinking on the topics before Agency policy is established in a final guidance document. While one can always comment on a final guidance document, it historically is more impactful for firms to provide their views before finalization of a policy.
If you have any questions on the draft guidance document, on FDA's request for additional feedback or on companion diagnostics generally, please feel free to contact us.

subset: commoncrawl


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Plus Size Clothing Pants For Curvy Girls
Bleat Front Trouser by Boohoo Plus
Pants fashion has gone a long way ever since women started to wear pants. Now pants, or slacks, or trousers are considered an essential item of women's wardrobe. Pants are comfortable, allow freedom of movement,…
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25 international judges participate in Wines of Portugal Challenge
Feb 19, 2014
May 13th – 16th at CNEMA, Santarém.
Viniportugal is planning the next Wines of Portugal Challenge to be held in CNEMA, Santarém this upcoming May. The challenge is an important program used to help Portuguese wines gain visibility in key export markets.
This year, the ViniPortugal Board is incorporating important decision makers in the challenge jury. At this point, the grand jury will be comprised of Shinya Tasaky, ASI president, Evan Goldstein (MS), Dirceu Viana Júnior (MW), the only Portuguese-speaking Master of Wine and Charles Metcalfe, in addition to the Portuguese wine experts Luis Lopes and Bento Amaral. Another 21 wine experts, mainly winemakers, will join the jury.
Through this program international judges will have an opportunity to better understand the Portuguese wine sector.
Challenge submissions will be available to winemakers on March 1st by visiting www.concursovinhosdeportugal.pt.
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1000 Ways to Die/Funny
Jump to navigation Jump to search
- Succu Offed: Two stoners have a shared hallucination after drinking cactus juice and are haunted by the booming voice of the spirit of a saguaro cactus who warns that they will be punished for stealing him from his natural habitat. Both stoners die by not looking where they're going in their attempt to escape the vengeful plant and end up impaled by cacti.
"Cactus voice": YOU HAVE PERTURBED THE UNIVERRRRRSE OF CACTIIIIIIIIIII!
- Boyz 2 Dead: A boy band that used to be popular in the 1990s is now reduced to playing at small clubs for bored audiences. The lead singer hears a woman with a camcorder scream his name and does a stage dive, hoping the audience would catch him. They don't and he ends up dead from the impact damaging his spine. The kicker: the other members of the boy band continue their performance after realizing the lead singer is dead.
- Work Of Fart: A frat boy is trying to win a farting contest by getting a coach with some of the weirdest methods imaginable. The coach dies when the frat boy accidentally ignites a big one, inadvertently setting the coach on fire.
- Even funnier is the frat boy's reaction:
"Oh, my god! My fart killed you!"
- Tali-Bombed: Two terrorists make a suitcase bomb connected to C4, using a GPS timer to have it explode in an hour. Several seconds after they prime the bomb, the timer starts to beep.
Terrorist 1: Daylight Savings Time!
- Em-Bear-Assed: A guy is high on shrooms and finds himself in a furry orgy. Wanting in, he finds a random furry and begins to screw it, only to find that it's an actual bear. He gets mauled. What makes it funnier is the narrator's recap of it.
Narrator: Let's recap what we learned from Randy's gruesome death: This is your brain, this is your brain on drugs, and this is a bear, ripping out your throat after you tried to have sex with it while you were high on drugs. The lesson? When nature calls, just say no.
- Died-Zilla: A woman who was in rehab for a drug addiction is getting married and receives bath salts as a wedding gift, which she snorts like cocaine. For the next couple of days, she acts nuts and when she finally gets to the altar, she drops dead from hyperthermia caused by a chemical in the bath salts. While everyone else is panicking over the bride's death, the best man and his buddy punch hands, as if they knew that the bride's death was some higher-power's way of saving their groom friend from getting married to a whacked-out harpy (the moment is subtle, but it's there).
- Colon-Gross-Oppy: A tomboy competes with her immature roommates in various contests, such as drinking beer and blowing balloons. When the time for a farting contest begins, she decides to one up them by sticking a can of whipped cream into her butt. But the gas from the can destroys her from the inside, killing her. As soon as the roommates show up to see what happened, though...
[The dead girl, who is bent over a couch with her butt sticking up, lets out a fart -- and blood sprays onto one of the roommates' face.]
- Down With The Clown: A birthday party clown named Funny Eddie is out to destroy a hip-hop Horrorcore duo called Infernal Clown Posse because he thinks they're ruining the reputation of clowns everywhere. Funny Eddie crashes one of their concerts and tries to get onstage, but gets hit in the head with a soda bottle. When he comes to, he decides to pull the plug on the concert and upstage the group. Turns out it's not such a good idea, as being drenched in soda made the clown conducive to the electricity in the wires and he got fried. Infernal Clown Posse's response: "IN! YOUR! FACE!"
- Even the ads can be pretty funny. The mere concept of The Grim Reaper doing Stand Up Comedy to describe the show is LOL-worthy.
- Gas Holed: A proctologist who has a thing for women's asses forgets to tell a stripper (who suffered rectal injury during a porno movie shoot) with a nice ass to not eat anything before operating on her. She eats a HUGE chilli dog and later lets out a big fart during the surgery. . . accidentally blowing up the cauterizer and burning the Dirty Old Man doc's face and lungs.
- Apocalypse Harley: In an homage to Apocalypse Now, a Marlon Brando-esque mercenary is hired to take down a Charlie Sheen-esque actor who's been all over the news for his cocaine abuse, his violence against women, and his erratic behavior (i.e., believing that he's a wizard and claiming that he gets all his powers from tiger blood). When the mercenary finally gets his man, the actor goes berserk and breaks out his machete to fight back against the mercenary. In his cocaine-and-tiger-blood-fueled insanity, the actor trips and impales himself on his own weapon. As his live-in floozies gather around him, the actor sputters, "Winning!" before dying. Bonus funny points for one of the floozies asking if the actor was "winning" or dying.
- Doggy Style: Two drunk hunters go hunt ducks with their dog. They try to use dynamite to kill the ducks without shooting them, but the dog mistakes this as a game and returns the dynamite sticks to them, accidentally killing them as it explodes. Made even funnier because it's all from the dog's POV; you can pretty much hear the Looney Tunes theme in the background.


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American Greatness Publisher Chris Buskirk returned to "PBS NewsHour" on Wednesday to discuss the Trump Administration's plan to phase out President Obama's unconstitutional Deferred Action for Childhood Arrivals (DACA) program. Buskirk joined host John Yang and Moveon.org's Karine Jean-Pierre for a spirited conversation.
JOHN YANG: Well, one of the issues there Congress is dealing with is what to do about DACA.
We take a look at the story of one dreamer growing up in Salinas, California.
Jose Anzaldo is now in his first year of high school. Filmmakers with our PBS colleagues "Independent Lens" have been following Jose since he was in third grade. Produced with USA Today, this is a follow-up to the film "East of Salinas," which is now streaming on the "Independent Lens" Web site until September 30.
This clip starts with Jose in the eighth grade.
JOSE ANZALDO, Undocumented Student: My name is Jose Anzaldo.
I'm in eighth grade, and I go to Washington Middle School. I'm good at math. When I grow up, I want to be an engineer.
Are you saying nine squared, plus six squared equals X-squared?
STUDENT: Can you try squaring them and them adding them, both?
I like learning. It can be fun sometimes.
STUDENT: Jose, what was your "a-ha" moment as you tried to solve this problem?
JOSE ANZALDO: I discovered that you could find it by just square-rooting it.
I was born in Mexico. My brother and my sister, they were born here. It's not like I'm supposed to feel like some other species. It's just — it's just I don't have papers. That's all. It's not a big deal.
It's not affecting me right now, but I know it will. And I will have to be ready for it.
OSCAR RAMOS, Teacher, Sherwood Elementary School: My name is Oscar Ramos. I'm a second-grade teacher. A few years ago, Jose Anzaldo was one of my students when I was teaching third grade.
Can you take away 8?
STUDENTS: No.
OSCAR RAMOS: No, you need to regroup.
He was a happy little guy, eager to learn.
Jose, you get the next one.
Jose reminded me a lot of myself as a child, growing up migrant.
JOSE ANZALDO: Mr. Ramos and I had a lot of things in common. I remember we both said we liked math, and we both like soup. It's delicious.
OSCAR RAMOS: Every year, I tell him that I was born in Mexico, and that I worked in the fields at a very early age.
We used to get up really early, like at 4:00 in the morning. And then we would go work for 10 hours, 12 hours.
And it's a great message for them, because they start to picture themselves being someone with a professional career, a teacher, lawyer, doctor, engineer.
I like seeing that in their faces when they realize, I can be someone.
MARIA GONZALEZ, Jose's Mother (through interpreter): Three of my children are from here, and one was born in Mexico. That's Jose.
JOSE ANZALDO: I do think my mom has a hard life, but I know that she can get through it.
MARIA GONZALEZ (through interpreter): Jose is still doing really well in school. I'm worried the most for Jose because he's undocumented.
JOSE ANZALDO: It's just, like, work on the amounts and see if that can help me learn more.
OSCAR RAMOS: A lot of our students don't have a very strong mentor in terms of education, educational choices. I think Jose sees me as a mentor, and I'm glad to play that role.
JOSE ANZALDO: I felt like I do have the right to stay here, because I have been here for so long, and I have done my best to learn here, so that, one day, eventually, I can help people here.
When I grow up, I think I want to be an engineer. An engineer has to really know math. And I like math.
I want to go to college, because my goal in general is just to have an education, and no matter what happens, I will still strive for more opportunities.
OSCAR RAMOS: Jose is more determined than ever to succeed, and I'm more determined than ever to support him. Do I have hope for Jose? Absolutely, 100 percent, yes.
JOSE ANZALDO: There's always a chance to do what you want to do, as long as you don't give up.
JOHN YANG: What to do about dreamers like Jose is just one issue dividing Republicans and the nation.
Here to walk us through the latest political fault lines is Karine Jean-Pierre, a veteran of the Obama administration and a senior adviser to MoveOn.org, and Chris Buskirk, editor of the online journal American Greatness, who joins us now from Phoenix.
Chris, let me start with you.
What happened this morning with the president and the leaders from Capitol Hill? The Web site Axios is quoting a top Republican as saying that what he did today was — quote — "the legislative equivalent of giving an entire stockpile of weapons to Democrats and inviting them to take the Republican Party hostage."
What do you think? What's your take on this?
CHRIS BUSKIRK, Editor, American Greatness: Well, I would love to know who gave that quote. I think that's pretty rich.
What we saw today, I think, is a warning shot across the bow of the Republican leadership, which has thought that they could get away with trying to control the White House from Capitol Hill, without ever actually having control of their own house, without ever having their own house in order first.
We have seen this Republican leadership over the past eight months do absolutely nothing. They have fulfilled none of the promises that they made to their constituents, let alone to the deals they had with Donald Trump about working on his agenda. They just haven't accomplished anything on the agenda. They don't have anything to show for this past eight months in office or in session.
And so I think Donald Trump is saying to them, look, if you guys aren't going to do something, if you guys aren't going to move legislation, then I'm going to find people to work with on Capitol Hill who will do it.
And this is why I think I have got to tell you, as somebody who supports Trump, as a Republican, I think it was a good move. The president has a responsibility to the American people, and I think he's trying to move things along in a way that is productive.
And the Republican leadership and the Republicans on the Hill need to take notice, and they need to fall into line.
JOHN YANG: Shot across the bow, Karine?
KARINE JEAN-PIERRE, MoveOn.org: Well, I have to say, John, I think Chris and I agree on something here.
I see it a little bit differently when — about the takeover. Look, I think that Republicans have allowed their party to be — to be taken over by Donald Trump, a hostile takeover. And all of these red lines that have been drawn from the last 18 months, especially into this administration, whether it was the Comey firing, "Access Hollywood," defending Nazis and white supremacists, they never — they allowed it to happen, essentially.
They had an opportunity to censure Trump, and they didn't do that. They had opportunities, many opportunities, to take action. They didn't do that. And so I think that this is on them, for sure.
But the other part of it as well is that Republicans own everything in Congress. They really do. Most of Trump's major agenda items, they needed 50 votes, not 60 votes, and they haven't shown that they could just really run a government on a basic level.
JOHN YANG: So, let's talk about that, talk about the — now the big test facing the legislature now, Congress now, Chris.
And I'm particularly interested in hearing what you think coming from Arizona about what the president did with DACA this week.
CHRIS BUSKIRK: Yes, it's interesting.
I mean, this is — there's a couple of things going on here. Of course, anybody who has followed this president as a candidate or as a president knows that this is one of his longstanding promises. So, no surprises here in one sense, right? This didn't come out of left field.
President Trump promised when he was candidate Trump to end DACA as soon as he got to the White House. He disappointed some of his supporters because he didn't do it in January or at least in February. That was an expectation based on those promises.
But what he's doing here, I think, is righting a wrong that has been really a bipartisan wrong that has taken place over 30 years, which is just the cynical ploy by both Republicans and Democrats to fail to deal with immigration on its own terms, not to pass any legislation, to hold people hostage.
They won't enforce the law, and they won't amend the law. And so it leaves people in limbo. And even Barack Obama, when he passed — not passed, but when he signed DACA back in June of 2012, that was a cynical campaign ploy leading up to the 2012 reelection. It was only a couple months before.
He said that he didn't have the power to simply unilaterally suspend deportations. I agree with him on that. The process here is important. To undo the executive order DACA, and to force Congress to do their job, which is to legislate on these issues, I think that's good government.
I think that, regardless of what you think of whether DACA as legislation should be in place or not, it has to come from the Congress. And I think we should have that debate as the American people and through our representatives in Congress and come to a resolution, and then live with it.
But this idea of holding people hostage because Congress fails to act, I think, is just wrong.
JOHN YANG: And, Chris, I just want to make sure I understand you correctly. You're making a distinction between the way — the policy itself and the way the policy was put in place?
CHRIS BUSKIRK: Absolutely, yes.
I think that they're two distinct things. What Donald Trump did — and he made the same distinction. He said, look, I'm rolling back DACA, but I'm giving it — on a six-month suspended sentence, so to speak, and I'm giving Congress time to work it out.
Well, that's Congress' job. They need to do it. Unfortunately, Congress has gotten way too good at not doing anything. We saw this with the debt ceiling thing today as well. Congress keeps — they specialize in nothing so much as just kicking the can down the road.
Well, now they have got something that they need to deal with that they should have dealt with a long time ago.
JOHN YANG: Karine?
KARINE JEAN-PIERRE: Well, here's — the fact of the matter is Donald Trump and his administration are sending a very clear and simple message, which is, if you don't not look like us, you do not belong in this country.
That is what they have been doing time and time again over the last eight months. And here's what I find really fascinating, is their argument. So, when it comes to Muslim ban, it's OK for Donald Trump to do a wide-authority Muslim ban and actually deal with immigration then.
But, when it comes to DACA, oh, no, you know what, let Congress deal with it.
And this is the same man who said, I alone can fix this. That's what he said going into the presidency. So, I think there's some inherent hypocrisy here that is quite unbelievable.
And I think the last point that I want to make is that it is remarkable to see that Jeff Sessions was the person who made this announcement, the same person who lied in front of Congress to get his job, which is probably — he probably committed some sort of — some sort of — he probably broke the law by lying in front of Congress.
And he's the one that made this announcement about these young people and if they should be here or not.
JOHN YANG: Chris, what about that comparison between the immigration policy and DACA, both executive action?
CHRIS BUSKIRK: Yes.
I mean, just, look, the president, obviously, has the ability to take executive actions. But what people have agreed upon is that with regards to — with regards to deportations, with regards to enforcing laws that have been enacted by Congress, the executive branch has an obligation to enforce those laws.
That wasn't the same instance with regard to what people call the Muslim ban, the travel ban. This was the same ban that was proposed, by the way, by the Obama administration. Right? This is nothing different.
I want to go back to what I think is the key point here, which is that Donald Trump is virtually begging Congress to send him a DACA look-alike bill, right? For him to say that he's saying you don't look like us and you're not welcome here, I don't think so.
And I don't think that what he said to Congress bears that out either. He is saying, look, this was done incorrectly. This is Congress' responsibility. Even Barack Obama said that he couldn't do what he ultimately did. Now, Congress, deal with it. Send it to me.
He hasn't said it explicitly, but he sure is sending the signal that if they send it to him, he will sign it.
JOHN YANG: Chris, Karine, I'm afraid we have got to leave it there.
KARINE JEAN-PIERRE: Oh.
JOHN YANG: You got something quick, maybe?
KARINE JEAN-PIERRE: No, it's just not true.
He is — he is appeasing his small and shrinking base. And just look at every action that he has taken. It has been about his small and shrinking base. This is a guy who defended white supremacy and Nazis. Come on now. That's just — that's not right.
JOHN YANG: Chris, Karine, thanks so much. We have got to leave it there.
CHRIS BUSKIRK: Thank you.
KARINE JEAN-PIERRE: Thank you.


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16th Annual Cross-Functional Alignment through S&OP/IBP
Encourage and support the negotiation, compromise, and consensus in a multi-function, multi-tier S&OP process that achieves better business results
9-11 March 2020
Radisson BLU, Amsterdam City Center, Netherlands
- Conference Workshop
The New Digital Reality of S&OP
No-touch planning, where humans are increasingly out of the loop, is fast becoming the new normal. Data, AI, machine learning: Break-speed technological innovations are having a huge impact in our field. But what does it mean for S&OP?
Workshop Moderator: Joost Rongen, Lead Senior Business Consultant
Company: EyeOn
- Why You Should Attend
16th Annual Cross-Functional Alignment through S&OP/IBP
Sales and Operations Planning provides the key communication links for top management to coordinate the various planning activities in a business, but also remains one of the least understood aspects in Supply Chain Management.
Better integration between functional areas in a business is one of the major payoffs of S&OP. Once collaboration between the top levels of the functional areas is developed, it can be translated into detailed plans that are in line with top level agreements. This results in a set of common goals, improved communication and transparent systems.
The fence mending process in a business and the cross-functional alignment through S&OP will figure prominently on the agenda. By attending this marcus evans pan-European and cross-industry conference you will be able to learn how to establish and optimise an S&OP network, and how to move the focus from Supply Chain Optimisation to financial benefits in the overall business. We will debate how the role of a one-number plan is likely to change and discuss the differences in planning. What can be said is there is a lot to play for � the challenges extend from synchronising forecasting, creating a common plan, to improving the decision making process by engaging the top-management. Join us for thought-provoking discussions and insightful case studies.


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Jump to navigation Jump to search
|Look up liking in Wiktionary, the free dictionary.
Liking may refer to:
- A form of the English verb "like"
- Use of a like option on social networking and some other websites
- Reciprocal liking, a psychological phenomenon
- Likin (taxation), in 19th- and 20th-century China
See also[edit]
| disambiguation page lists articles associated with the title Liking.
If an internal link led you here, you may wish to change the link to point directly to the intended article.


text: Agreed It's places like Aetherone's shop that other shops should be looking up to. One would hope that if all the shops did it manufactures would be forced to produce better quality panels at higher quality standards to save everyone the time and money. I realise one dead pixel is literally one in a million across the whole panel, but surely this is an issue that can be solved indefinitely? That's crazy


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Requirements of Applicant
Applicants must hold a master's level degree and have a minimum of 3 years of professional experience in Kinesiology or related fields to be accepted into the program.
Application Materials
Required application materials include:
- Graduate School Online Application
- Official GRE Scores – *Optional for 2021 Applicants Due to COVID-19
- Official Transcripts
- Recommendation Letters
- EdD in Kinesiology Supplemental Application
- Resume/CV
- Professional Goal Statement
Review of Applications and Required Orientation
- Applications are reviewed in the spring for fall admission, beginning January 15.
- Completed applications must be received by April 1 for fall admission.
- If admitted, you are required to attend a three day orientation over the summer to enroll in the program. Orientation dates: TBD
Please follow these guidelines when submitting your application.
See our FAQ page for some of the more common questions regarding the application process.
Here is what our students have to say about the program!
I was so excited when I found the doctoral program at UNCG! It has given me the flexibility to continue teaching and gaining experience while staying in my local community. The reputation and history of UNCG to actively prepare future faculty and academic leaders is what has impressed me the most.
Meaghan Howard, 2015 Cohort, Adjunct Faculty at Rowan-Cabarrus Community College
I became interested in the EdD in Kinesiology program because of its history and strong reputation, along with its accomplished faculty and alumni base. Adding to this the fact that the program is now offered online, solidified my decision to apply for the first cohort because I would be able to keep my full-time employment as an athletic trainer while attending school. The online format of the program allows me to stay connected with my faculty and cohort regardless of our geographic location; I've even been able to take part in discussions and video chats while travelling internationally!
David Wilkenfeld,2014 Cohort, Athletic Trainer & Coordinator of Clinical Education at University of North Carolina School of the Arts


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Camping Iberá, Colonia Carlos Pellegrini's municipal campground, is a paradise within the Iberá paradise. Lucky travelers with a tent can choose from the ten sites right on the north shore of Laguna Iberá. Each one has a quincho (picnic shelter), parrilla (barbecue grill) and table. The clean, common bathhouses have hot water. Early mornings and at night, capybaras graze through the well-maintained grounds. At these hours, the mosquitoes also make an appearance, as do yacarés in the nearby marshes. Campers have the most privileged spot for watching the sunset.
800 meters (0.5 mi) south of Ruta Provincial 40 and Yacaré
Campground Types:
Ecological camping, Lakeside camping
This Hotel is: Budget
Hotel Amenities, Services and Facilities , 24-Hour Hot Water, BBQ Area, Child-Friendly Facilities, Parking - Extra Charge, Taxes Included in Price, Travel Info Desk
Currencies accepted
Argentine Peso
Room Prices:
Contact Information:
Phone: 1562-9656 / 1540-8474
E-mail: municipalidad.pellegrini(at) gmail.com
URL: www.coloniapellegrini.com.gov.ar
Upon re-declaring her independence at age 29, Lorraine Caputo packed her trusty Rocinante (so her knapsack's called) and began...
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New Youtube Video: The Dream House (Modern Times)
We've uploaded another clip from Modern Times to our Youtube channel, TheChaplinFilms. Watch it below, and subscribe to our channel if you would like to stay updated on new videos.
We've uploaded another clip from Modern Times to our Youtube channel, TheChaplinFilms. Watch it below, and subscribe to our channel if you would like to stay updated on new videos.
Happy Valentine's Day from the Chaplin Office!
"Simplicity is a difficult thing to achieve" is one of our favourite Chaplin quotes here at the Chaplin Office and we hope this new version of our website brings it closer to such a goal.
Our first concern was to enhance its very rich content: inspired by the best blogging platforms (like Medium), we removed all distracting elements from our articles, increased the font size and, last but not least, added hundreds of contextual images with captions to offer you a much more focused and pleasurable reading experience.
We also wanted to bring the content to light. Our website has some 200 articles, and in the previous version of our website, they were buried under layers of 4 or 5 mouse clicks. It was a real shame - considering the short attention span of the Internet, that was equivalent to their being virtually nonexistent!
Now, under the new Media menu, song lyrics, the speech from The Great Dictator, film synopses, and many other articles are all just one or two clicks away. In the same vein, our Films section now includes a page per film, on which all of the content (descriptions, videos, articles, lyrics, etc.) relevant to each particular film is much more easily reachable.
We hope that the Films section's new design offers an inviting "screening" space, where you can (re)discover over 75 film excerpts, trailers & rare archival footage from our Youtube channel, but proposed and sorted within the context of each film, and no trolls or lolcats to distract you! The videos can also be easily found in the Media section.
Many of the videos and articles on the website have only recently been added, such as Lisa Stein Haven's hitherto unpublished interview with the late Julian Ludwig, who played a small part in Limelight, so do browse around. We will of course continue adding articles, blog posts, videos, new products, etc. with time.
Finally, the design has been brought down to a bare minimum with a black and white colour frame to remain consistent with much of Chaplin's work. Though we liked the previous homepage design, we feel Chaplin speaks for himself, even in the silence of a black and white photograph - there's no need to dress him up with fancy colours and icons: simplicity is key.
A new Romanian edition of Chaplin's "My Autobiography" has been released by Editura Nemira.
Available on Editura Nemira's website.
Restorations of Charlie Chaplin's "The Kid" and Buster Keaton's "Sherlock Jr." will be released in Italian cinemas on January 9th.
Visit the Cinema Ritrovato website for full details.
The excellent film restoration work of Bologna's Immagine Ritrovata lab is featured in this recent piece on Euronews.com.
We've uploaded a new video to our Youtube channel, TheChaplinFilms, featuring footage from the Chaplin archives of Chaplin reading his fan mail. Watch the archive footage below. And don't forget to subscribe to our channel to stay updated on new videos!


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How to scan a business card?
It's very easy to scan a business card with Genius Scan:
- 1
Make sure OCR is enabled on your device.
- 2
Scan the card as you would scan any other document with Genius Scan.
- 3
Once you have scanned the card, Text Recognition will be automatically performed and you will be able to access the metadata in the OCR menu:


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LUCAS, Colleen Mable
Passed away peacefully on February 13th, 2019 at Strathroy Middlesex General Hospital in her 80th year. Loving wife of the late Gary Lucas. Beloved mother of Wendy Boulet, Lorrie (Barry) Scharf, Sherrie (Allen) Cresswell, Terrie (Robert) Sanderson. Grandmother of Brendan, Jacob, Kayla, Jennifer, Nikki, and Chase. Great Grandmother of William, Samantha, George, and Conor. Cherished Sister of Norma (Wayne) Somers, James "Skip" Hamm and the late Roger Hamm. She will be missed by many nieces and nephews.
The family has had a private service. Donations may be made to Strathmere Lodge Recreational Department or Alzheimer's Society. Condolences may be left at www.strathroyfuneralhome.com.


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|Just hanging with two of my BFFs on a totally normal hair day.
If you know me well, you know that one of the beliefs I deeply and firmly cling to is this:
|Case in point: once she ordered 99 pizzas to feed some hungry celebs who were trapped for hours in theatre seating and probably uncomfortable formal-wear.
For a while, I had a few wishes I tossed around. My top three (in no particular order) were that she would:
- Set me up with Josh Groban (If he didn't steal your heart in his Best Tweets of Kanye West bit on Jimmy Kimmel, check out his Best Tweets of Donald Trump.)
- Secure a spot for me to audition for a Broadway show
- Something normal- like a vacation
Obviously I'd still take a vacation (who wouldn't?), but since becoming a foster parent I have a new wish that takes priority.
If you've followed along on this blog for the past year- or if you just found it and have backtracked a bit- you know that last year I wrote a letter to Ellen asking her to dedicate her annual Mother's Day show to foster moms. The letter was kind of long, but the main reasons behind this wish were 1.) foster moms are awesome, and 2) it would be such a great way to promote foster care- during National Foster Care Awareness month, no less! As great a a vacation would be, I can figure that wish out on my own. What I cannot do is magically expand my sphere of influence to match the level of Ellen's. She has such a positive impact on so many people, so for her to share the world of fostering with others would be incredible.
I don't think my letter got very far last year, but I've decided writing one will now be my annual tradition in the hopes that, one day, she'll read it.
Obviously my personal experience makes me a little biased, but the concept of a Foster Mother's Day episode really just seems perfect to me. Ellen loves making the world a better place. Her last name has the word "generous" in it, for Pete's sake! Misspelled, perhaps, but all my last name has is the word "egg", so I'm pretty sure she still wins that one.
On top of that, her motto is "Be kind to one another," which is sort of like the unspoken motto of foster parents. And did I mention the episode falls during Foster Care Awareness month? Because it does.
So here's my letter for this year.
I'd love it if you considered reading and sharing it. As I said last year, if we're all just 7 degrees from Kevin Bacon, we have to be only 5 or 6 from Ellen. She seems to know a lot of people.
Be sure to tag Ellen when applicable- and use the hashtags #BeKindToOneAnother and #FosterMoms4Ellen if you can squeeze them in there. Admittedly, I'm not very savvy when it comes to social media, but from what I understand hashtags are the best way for things to spread on the internet these days. (If that's changed in the last few years, please, someone let me know. I'm too young to be so out of the loop with technology.) (Also- I'm open to other hashtag ideas- I just couldn't think of any better/shorter ones.)
*For those of you who don't know me personally, it feels important for me to clarify that I was joking about me obviously getting a part in a Broadway show.
In one hand, you hold the truth that these children are your own. You open up space for them in your home and heart, and you care for them as if you gave them life and will walk with them through it from start to finish. You love them completely and without condition.
But then, in the other hand, you hold the truth that there's another family out there- one they could return to any day. You have to accept that, no matter how much love you pour into them, they might not remember your name- or you at all- years down the road.
And those are hard realities to reconcile.
If there is a way to love my son completely while still protecting my heart from the grief of losing him, I haven't figured it out yet. But, despite the uncertainty and heartache, I hope to continue fostering children- as so many parents around the country do- because there is such a tremendous need, and I know this is one way I can do something about it.
But over the past year and a half my eyes have been opened to the many mothers out there whose stories aren't always celebrated- or even shared. From women who are led to foster care because they are unable (or choose not) to have children biologically, to women who become foster moms just so kids can experience safety and love before finding permanency with their biological or adoptive family- there are many mothers out there who don't necessarily bring lives into the world, but they certainly work hard to make sure those lives thrive. Their stories are complex and challenging, but they are also beautiful and very much worth telling.


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Currency Displayed in
Made in the USA in an ISO 9001:2008 certified facility and manufactured and tested in accordance with API Q1 Specification standards, ASR Tree Saver Winch Straps are made of premium quality, high capacity heavy duty polyester with reinforced edges and a protective layer of Cordura on the inside of the eyes and down the length of one side for excellent durability. These design features make this Tree Saver Strap ideally suited to protect trees while providing a strong anchor point with minimal stretch. They can also be used as a short distance tow strap, winch line extension strap, snatch strap or recovery strap. ASR's Tree Savers are resistant to UV radiation, water, mold and temperature variation, thereby ensuring a long service life. They can be used with any ASR Offroad Recovery Gear and virtually all brands of self-recovery winches on the market.
ASR's 3" x 6' Tree Saver Winch Strap has an MTS of 46,500 lbs. Applying an industry standard 5:1 Safety Margin yields the following Working Load Limits - V:9,300 lbs, C: 7,440 lbs, B: 18,600 lbs.
This product hasn't received any reviews yet. Be the first to review this product!
All prices are in USD.


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Sweet Things ~ Love Always Hearts And Dream Catcjers
Spring & Easter
Pretty China & Unique Items
Towels For All Seasons
Vintage Linens
Cottage Pillows
Handmade Blossoms & Ribbon Embroidery
Pretty Pumpkins
Christmas Joy
HomeCatalogLovely LinksAbout JilJil's BlogSign up for our NewsletterContactGift CertificatesOrder TrackingGuest BookPOLICIESLayaway
View Your Cart
Dream Catcher Dreamy Creamy Lacy Shabby Sweet Yards Of Vintage Laces
Your eye goes right to the pretty hand crocheted doily that catches and holds all your magical dreams ~
There is a flouncy, vintage ruffle of Battenburg lace ~ a lovely olden millinery roses with other blossoms that are new and vintage ~ Under the rose is a beautiful 1 1/2" pure silk ribbon bow with the tails flowing with the laces ~
This charmer hangs from a 5 1/2" loop of dainty, narrow hand crocheted lace `
The hoop is 9"
The laces have a 19" drop
This is a treasure you will love for years to come ~
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Temperature for December 1956
In December 1956 the average high temperature in Barrow, AK was -3.1°F, and this was 1.0°F warmer than the average of -4.1°F. The hottest day in December 1956 was 4 December when the temperature reached 21.0°F. Overnight the average temperature in December is -16.5°F and in 1956 the average overnight temperature was 0.5°F warmer at -16.0°F.


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Take Care New York (TCNY) 2020 is the Metropolis's blueprint for giving each New Yorker the possibility to dwell a healthier life. The desk below shows the vitamin content material of the man's every day weight-reduction plan of eggs. The vitamin K2 content material provided by was incorrect; I needed to get what appears to be the precise quantity by triangulating values taken from various publications. And here we see something interesting. This man was consuming approximately the equal in vitamin K2 that one would get by eating 4 ounces of foie gras ( ) day-after-day. Foie gras, the fatty liver of overfed geese, is the richest known animal supply of vitamin K2. This man's weight-reduction plan was also high in vitamin A, which is believed to behave synergistically with vitamin K2 – see Chris Masterjohn's article on Weston Value's activator X" ( ).
Staffan was a devoted researcher and physician at Lund College in Sweden whose work was impressed by the evolutionary health principle. After studying Boyd Eaton and Melvin Konner's seminal 1985 paper on Paleolithic diet, in Staffan's words, "it regularly dawned on me that John Harvey Kellogg, a vegetarian zealot, had extra affect on dietary advice than Charles Darwin had" (Staffan Lindeberg. Meals and Western Illness. 2010). Long before it was en vogue, he adopted a Paleo-model weight-reduction plan and noticed his own persistent illness threat elements, similar to body weight and blood pressure, decline.
We are starting Day 4 discussing another very important a part of achieving the body you want. Easy methods to set practical health objectives will be the begin of a successful program and adopting a healthy life-style It is important to start your journey of getting match with a sensible mindset. We worry about what our doctors will tell us – and so do they. Doctors, scientists and medical researchers weigh in on health care and higher health practices. Tuesday night a buddy of mine despatched me a text regarding insurance for his worker. Because it's solely two workers in his small enterprise they don't provide a bunch plan. The textual content trade below is why the middle class is getting crushed with Obamacare. It's also an enormous motive why using a professional insurance agent can make an enormous difference.
And producing such beneficial data requires ample quantities and diversities of legitimate and reliable data. A few of these requisite knowledge can come from in the present day's "Large Information" shops, which are typically insurance claims (administrative) information While such claims knowledge have usefulness, they are grossly inadequate in relation to creating the kinds of knowledge and rising the sorts of scientific knowledge obligatory to enhance care quality and value in any actually meaningful method.
A value community is a advertising and marketing idea that describes the social and technical assets (provide chain) within and between businesses. They account for the general worth of services, including the collection of upstream suppliers, downstream channels to market, and ancillary services that assist a typical business mannequin inside an industry. The form of value community that the healthcare system wants focuses on bringing elevated worth to healthcare patient (client) and reward providers for delivering excessive-value care.


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Jerusalem wins State Cup; Brown, Feldeine, Thomas & Katash Star in victory
3-Pointers 1) Will Hapoel Jerusalem's State Cup victory go down as one of the all time great games? Most probably not, but it was a heck of a showing in the third quarter by the Reds who were wearing black. Katash's side came out flying in the second half and just demolished a tired Rishon team [Read More]


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Ok. There is only one "Whitest Guy" (Ben Franklin certified) and so I have unwittingly Doxxed myself as John Oliver.
You should now re-read all my posts ever in a British accent. They'll sound much more authoritative and classy.
That's what Game of Thrones money gets you.
Wanda Sykes.
As the whitest guy in the room and having spent a piece of time in the body and fender shop let me tell you my experience. You never sleep. Ever. While you stare out the window at the sun rise over the dank industrial city your symptoms deserve (why do they put Hospitals on hills?) or the tv feed of magnificent landscapes, artistically framed with soothing music, both designed to distract you from your imminent mortality.
Yes, they really do use "Code Blue".
I had the benefit of having a Nurse at the station specifically curse me out by handle (do you really think I'm John Oliver? Really?) "ek hornbeck" at random. Some people I interact with in meatspace know I write but I don't make a big deal about it and I was sick, self promotion was a secondary consideration. Well, it was an instructive insight into dK politics at the time (which I no longer care about other than- Told You So!) and kind of flattering.
I was that big a deal.
I'd pass it off as medication hallucination except it happened again at the next Shift Change. You never sleep, ever.
Finally my real Doctors (I'm picky) saw me and decided palliative care and monitoring was all I required and I was released into the general population where my diet varied not a bit off "clears" despite numerous inqueries and promises for 4 days, and before I was released I was expected to defecate in a bowl to prove I was healthy enough.
Nurses generally like me (White Guy) because I'm funny and don't complain much. They decided to sign off and now I'm told all you have to do is prove you can eat solid food without barfing.
But the funniest part is that I languished in post-op for hours, waiting for my previous care team to sign off on my transfer. As darkness fell they trooped in, Lab Coated Penguins in a long line, who asked me all the same questions that had already been answered a dozen times before.
That's a test by the way, it shows you're aware of your surroundings and can give coherent responses that confirm your previous statements. You never appreciate that Whiteboard with the day and the date on it quite as much as you do after a medically induced coma.
They poked and prodded because I am a miracle of medicine and everyone is surprised I'm still pissing on them and marched out, astonished I suppose that I survived their care.
Thanks for emptying my barf bowl. Once.
I mean it sincerely. Because of my publicly funded health care I am alive today and I feel my medical treatment has been nothing else but upstanding despite several attempts by my Doctors to kill me. So Medicare for All! It doesn't suck, especially if you have an advocate and learn the names of your Doctors and pay attention. Like everything else the libertarian instinct is to acquire or hire the expertise I've been afforded by sentiment but I don't think like that.
I could have died yet I'm here to inflict you with more punishment.
How cool is that!


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Windy weather Saturday morning into the early afternoon shut down the Assistance Fair. I meet representatives of Blue Star Moms, Memorial Service, Director: Combat Vets Motorcycle Club, and Dod Employer Support of The Guard and Reserve.
Thanks to Connie Wolf for her help and the kindness extended by all participants. Thank You, so much !


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Simple Fall recipes make delicious treats
Sydney Kaplan, Staff Writer
October 29, 2015
Four Ingredient Muffins These 4 Ingredient Muffins are not only beyond simple, but beyond delicious. Made with ice cream, flour, baking powder, and your choice of addition. I choose to make half of the batch with blueberries and the other half with chocolate chips. Both were amazing and so easy to make on a cool fall morning. ...
Food Network cooks up an audience at Staples
Caroline Cohen, Managing Editor
March 23, 2015
It's the most frequently asked question during an ice breaker conversation. The answer's range from ice cream to sushi to pancakes and every meal in between. What is your favorite food? It's asked because everyone can answer it, and if they can't it's because there are too many answers....
Work hard, cook hard
Jackie Sussman, Assistant Business Manager
September 3, 2014
Rewind back in to summer 2014, specifically to July 29th. For some Staples students, it was just another chill day of relaxing and having fun with friends. But instead of chillaxing, Hannah Bukzin '17 was sweating it out, trying not to get chopped on Food Network's Chopped Teen Tournament....


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The Christmas Gift of Reading
The National Literacy Trust are offering the Gift of Reading this Christmas. For as little as £7, you can buy the Gift of Reading gift card for your friends or family and the National Literacy Trust will use the money to give disadvantaged children books to keep. A shocking statistic is that one in seven children in the UK does not have a book of their own.


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David Cameron speech- UK leaves the EUDownload
© Licensed to London News Pictures. 24/06/2016. London, UK. Former British prime minister TONY BLAIR seen leaving the same building that the VOTE LEAVE use for their campaign headquarters, on the day that the UK voted to leave the EU in a referendum. Photo credit: Ben Cawthra/LNP
- Filename
- LNP_Leave_EU_BCA_45.JPG
- Copyright
- ©2016 Under licence to London News Pictures +44 208 088 1155 email@example.com
- Image Size
- 2129x3200 / 980.9KB
- londonnewspictures.co.uk
- Contained in galleries


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Prefabricated Telecom Shelter
Price And Quantity
- 1-10
- Piece/Pieces
Product Specifications
- Steel
- Other
- Other
- Steel
- Steel
- One
- Two
- Sliding Window
- Ms steel
- Workshop, Shop, Office
Product Description
Prefabricated Shelter is used to carry out off-site contract works in a hassle-free way. This prefabricated shelter is perfect for both residential and commercial places. Our offered office prefabricated shelter is widely demanded in the market due to its rugged construction and durability. Prefabricated Shelter is design based on space utilization and size. We offer this product in different specifications and can be customized as per detailed requirements of our buyers.
Trade Information
- Cheque
- 10 Per Week
- 1 Week
- Yes
- Contact us for information regarding our sample policy
- All India
Contact Us
B No 14 2, Shil Diva Road, Shil Gaon, Navi Mumbai, Maharashtra, 400612, India
Phone :+918037405117


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This is one of my send invented recipes. Many people don't like liver, but for those who like it it's a nice alternative to the usual preparation.
You can use the same sauce (a glass of each balsamico, red wine and water) also for steaks. Refer to this recipe: Steaks with mushrooms in balsamic
- Chicken liver (or if you can't get it, turkey liver), 200g per person
- 1-2 onions sliced in rings
- Garlic
- Flour
- Half a glass of balsamico
- 1 -1,5 teaspoon of sugar
- Olive oil
- Baguette
Here we go
Prepare the corn salad using your preferred dressing. A good dressing for this is olive oil, balsamic and a bit of mustard.
Chicken or turkey liver and some flour. Add only pepper to the liver, if you need salt you can add it later. If you use turkey liver (like I am using here) cut it in smaller pieces.
Cut the onion in rings and the garlic in slices. Prepare olive oil and half a glass of balsamic. Later you will need the same amount of water.
Turn over the peppered liver pieces in flour.
Pan fry the onions not too hot. Use olive oil if possible.
Right before the onions are ready add the garlic. Reduce the temperature and steam for 2 minutes. Remove everything from the pan and increase the temperature again.
Fry the liver in portions but do not overheat it, otherwise it will 'explode'. The frying takes 6-8 minutes per frying pan. The liver need not be completely through. Remove finished pieces (thinner pieces first) and place separately on the onions.
Once you are finished with the liver add 1 to 1.5 teaspoons of sugar and caramelise it in the hot pan.
Add the onions and the garlic again and stir. Now add the Balsamico It will steam a lot but cook in slightly for 1-2 minutes to dissolve the frying set. Add the same amount of water and stir.
Finally add the liver and cook slightly for roughly 6 minutes. You may have to add some more water.
The liver is the topping for the salad and you are ready.
And here the gallery. Click on a picture to see a high resolution.


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In answering the basic question posed by this article, we will first attempt to determine what guidelines the Bible provides regarding the types of offenses that are to be punished by some kind of capital punishment (i.e., an execution). Then, we consider information from secular sources that should be helpful in assessing the propriety of the death penalty for any type of offense.
Biblical Sources Regarding the Death Penalty
The following biblical passages advocate putting people to death for a wide variety of offences including murder, kidnapping, deadly negligence, idolatry, blasphemy of God's name, working on the Sabbath day, seriously abusing a parent, sexual immorality, engaging in bestiality, and acting as a medium.
[Note: When we quote Scripture in this article, we use the wording in the New King James Version of the Bible, unless indicated otherwise.]
Exodus 21:12-14 applies the death penalty to anyone who premeditatedly kills a person by striking that person, as follows:
He who strikes a man so that he dies shall surely be put to death. However, if he did not lie in wait, but God delivered him into his hand, then I will appoint for you a place where he may flee. But if a man acts with premeditation against his neighbor, to kill him by treachery, you shall take him from My altar, that he may die.
Numbers 35:16-18 also pertains to putting to death a person who commits murder by striking another person, as follows:
[If a man strikes another man] with an iron implement, so that he dies, he is a murderer; the murderer shall surely be put to death. And if he strikes him with a stone in the hand, by which one could die, and he does die, he is a murderer; the murderer shall surely be put to death. Or if he strikes him with a wooden hand weapon, by which one could die, and he does die, he is a murderer; the murderer shall surely be put to death.
Numbers 35:20-21 likewise asserts that the death penalty is warranted when a person murders someone else by striking or pushing them. This passage asserts,
If [a man] pushes [another man] out of hatred or, while lying in wait, hurls something at him so that he dies, or in enmity he strikes him with his hand so that he dies, the one who struck him shall surely be put to death. He is a murderer. The avenger of blood shall put the murderer to death when he meets him.
Exodus 21:16 advocates putting to death anyone who kidnaps another person, as follows:
He who kidnaps a man and sells him, or if he is found in his hand, shall surely be put to death.
Deadly Negligence
Exodus 21:28-29, which pertains to putting to death a person whose negligence results in the death of someone, states,
If an ox gores a man or a woman to death, then the ox shall surely be stoned, and its flesh shall not be eaten; but the owner of the ox shall be acquitted. But if the ox tended to thrust with its horn in times past, and it has been made known to his owner, and he has not kept it confined, so that it has killed a man or a woman, the ox shall be stoned and its owner also shall be put to death.
Deuteronomy 17:2-5 indicates that anyone who worships gods other than the one true God should be stoned to death, as follows:
If there is found among you, within any of your gates which the Lord your God gives you, a man or a woman who has been wicked in the sight of the Lord your God, in transgressing His covenant, who has gone and served other gods and worshiped them, either the sun or moon or any of the host of heaven, which I have not commanded, and it is told you, and you hear of it, then you shall inquire diligently. And if it is indeed true and certain that such an abomination has been committed in Israel, then you shall bring out to your gates that man or woman who has committed that wicked thing, and shall stone to death that man or woman with stones.
Deuteronomy 13:6-10 infers that anyone who attempts to entice another person to serve any god other than the one true God should be put to death. According to this passage,
If your brother, the son of your mother, your son or your daughter, the wife of your bosom, or your friend who is as your own soul, secretly entices you, saying, 'Let us go and serve other gods,' which you have not known, neither you nor your fathers, of the gods of the people which are all around you, near to you or far off from you, from one end of the earth to the other end of the earth, you shall not consent to him or listen to him, nor shall your eye pity him, nor shall you spare him or conceal him; but you shall surely kill him; your hand shall be first against him to put him to death, and afterward the hand of all the people. And you shall stone him with stones until he dies, because he sought to entice you away from the Lord your God, who brought you out of the land of Egypt, from the house of bondage.
Blasphemy of God's Name
Leviticus 24:16-17a makes it clear that blasphemy of God's name is an offense worthy of death. This passage states,
And whoever blasphemes the name of the Lord shall surely be put to death. All the congregation shall certainly stone him, the stranger as well as him who is born in the land. When he blasphemes the name of the Lord, he shall be put to death.
Working on the Sabbath Day
Exodus 31:15 condemns to death anyone who works on the Sabbath day, declaring,
Work shall be done for six days, but the seventh is the Sabbath of rest, holy to the Lord. Whoever does any work on the Sabbath day, he shall surely be put to death.
Exodus 35:2, which is worded similarly to Exodus 31:15, likewise condemns to death anyone who works on the Sabbath day.
Numbers 15:32-36 is a specific account regarding a man who was stoned to death because he worked on the Sabbath day. This passage states,
Now while the children of Israel were in the wilderness, they found a man gathering sticks on the Sabbath day. And those who found him gathering sticks brought him to Moses and Aaron, and to all the congregation. They put him under guard, because it had not been explained what should be done to him. Then the Lord said to Moses, "The man must surely be put to death; all the congregation shall stone him with stones outside the camp." So, as the Lord commanded Moses, all the congregation brought him outside the camp and stoned him with stones, and he died.
Seriously Abusing a Parent
Exodus 21:15, 17 sanctions putting to death a person who strikes or curses one of their parents, as follows:
[H]e who strikes his father or his mother shall surely be put to death. . . . And he who curses his father or his mother shall surely be put to death.
Leviticus 20:9 likewise applies the death penalty to cursing a parent, asserting,
[E]veryone who curses his father or his mother shall surely be put to death. He has cursed his father or his mother. His blood shall be upon him.
Sexual Immorality
Leviticus 20:10-13 decrees that the death penalty be applied to four types of sexual immorality. According to this passage,
The man who commits adultery with another man's wife, he who commits adultery with his neighbor's wife, the adulterer and the adulteress, shall surely be put to death. The man who lies with his father's wife has uncovered his father's nakedness; both of them shall surely be put to death. Their blood shall be upon them. If a man lies with his daughter-in-law, both of them shall surely be put to death. They have committed perversion. Their blood shall be upon them. If a man lies with a male as he lies with a woman, both of them have committed an abomination. They shall surely be put to death. Their blood shall be upon them.
Engaging in Bestiality
Leviticus 20:15-16 indicates that bestiality is a crime punishable by death, as follows:
If a man mates with an animal, he shall surely be put to death, and you shall kill the animal. If a woman approaches any animal and mates with it, you shall kill the woman and the animal. They shall surely be put to death. Their blood is upon them.
Acting as a Medium
Leviticus 20:27 advocates the death penalty for people who act as mediums through whom communications are thought to be sent to the living from the spirits of the dead. According to this verse of scripture,
A man or a woman who is a medium, or who has familiar spirits, shall surely be put to death; they shall stone them with stones. Their blood shall be upon them.
Secular Sources Regarding the Death Penalty
An article on the website The Guardian (https://www.theguardian.com/us-news/2017/dec/13/us-death-sentences-executions-2017) reports that 23 people were executed and 39 sentenced to death in 2017 in the USA. There is no way of knowing how many of these people and the others in our country who are sentenced to death each year will subsequently be found innocent.
According to another website, https://deathpenaltyinfo.org/documents/2017YrEnd, "There were five more exonerations from death row in the United States in 2017, bringing the total to 161 men and women exonerated since 1973. . . ." In other words, an average of approximately four people per year in the USA have been exonerated from death row since 1973. This raises the question as to how many of those who have been executed were innocent. It is tragic enough for a person to spend many years in prison for a crime that they did not commit, but it is arguably worse for a person to be executed for a crime if they are innocent of that crime.
Furthermore, in his highly acclaimed book entitled Just Mercy, Bryan Stevenson, an American lawyer, social justice activist, founder/executive director of the Equal Justice Initiative, and a clinical professor at New York University School of Law, indicates that many hundreds, if not several thousand, people may deserve to be exonerated.
On page 16 of his book, he states,
Scores of innocent people have been exonerated after being sentenced to death and nearly executed. Hundreds more have been released after being proved innocent of noncapital crimes through DNA testing. Presumptions of guilt, poverty, racial bias, and a host of other social, structural, and political dynamics have created a system that is defined by error, a system in which thousands of innocent people now suffer in prison.
Then, on page 17 Stevenson says,
[One case in particular] "taught me about our system's disturbing indifference to inaccurate or unreliable verdicts, our comfort with bias, and our tolerance of unfair prosecutions and convictions. [That case] taught me how our system traumatizes and victimizes people when we exercise our power to convict and condemn irresponsibly – not just the accused but also their families, their communities, and even the victims of crime.
Following the exoneration of the man alluded to on page 17 who had been convicted of a murder he did not commit and whom Stevenson had helped to exonerate, Stevenson states on pages 224-225,
I thought about how certain it was that hundreds, maybe thousands, of other people were just as innocent as [his client] but would never get the help they need.
Subsequently, on page 227, Stevenson declares,
The number of death row prisoners in Alabama for whom we'd won relief reached one hundred. We had created a new community of formerly condemned prisoners in Alabama who had been illegally convicted or sentenced and received new trials or sentencing hearings. Most never returned to death row.
With regard to what Stevenson states on page 227, it seems likely that if there were 100 such cases in Alabama alone, there may have been several thousand such cases throughout the entire nation that could have qualified for new trials or sentencing hearings during that same period.
It is possible to conclude from the foregoing information that either all the offenses that have been mentioned in this article should be punished by execution or none of them should be punished by execution. However, our society has chosen a compromising approach.
On the one hand, the Old Testament scriptures we have cited indicate that the death penalty is the decreed way to deal with all the offenses that we have mentioned in this article. In other words, the Old Testament indicates that our society should not make any distinction in the punishment for those offenses. In other words, the death penalty should be administered without regard to what our society perceives as differences in the seriousness of the offenses that we have mentioned.
The distinctions made by our society as to which of the previously mentioned offenses should be – or not be – punished by execution are secular distinctions, not biblical distinctions. Nevertheless, a majority of the people in our society, including many Christians, believe that murder and certain other heinous offenses are much more serious than most of the other offenses and, therefore, these offenses should be punished by execution in many, if not most, cases.
On the other hand, it can be argued with regard to this matter, as well as to other matters, that unless a biblical command that is found in the Old Testament is reaffirmed in the New Testament, it is no longer valid. If this viewpoint is valid, then perhaps there should not be a death penalty for any offense, because the New Testament does not reaffirm the decree to put someone to death for any of the previously mentioned Old Testament offenses – not even murder. Likewise, it is questionable if the death penalty is justifiable for any offense if the Old Testament laws have been superseded by New Testament standards that advocate love, mercy, and grace for everyone, as many Christians believe. Thus, a sentence of life imprisonment without the possibility of parole is arguably sufficient retribution for murder and other heinous offenses.
Perhaps, the strongest argument against capital punishment is that there should be little doubt that the death penalty has been administered in cases in which the person who was put to death was innocent of the crime for which they were found guilty. The fact that many people have been exonerated before they were put to death suggests that it is reasonable to assume that it is probable that many other people have been put to death before they could be exonerated.
In any case, people who seek the death penalty for any offense should at least examine their motive for doing so. Their motive may be revenge rather than justice, whereas God does not want us to take revenge. Romans 12:19 asserts, "Beloved, do not avenge yourselves, . . . for it is written, 'Vengeance is Mine, I will repay,' says the Lord." [For a discussion of relevant considerations in this regard, click on "Judging, Anger, and Forgiveness."]
We conclude that the manner in which the death penalty is imposed in this country is not consistent with either the Old Testament or the New Testament, nor is it consistent with a judicial system that supposedly seeks justice for everyone, especially for those who are truly innocent of the offense for which they are accused. Certainly, innocent people will still be convicted of offenses of which they are not guilty, because our judicial system is not perfect, but if capital punishment is abolished, these people can still have life – and hope that they will be exonerated before they die.


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We watched in awful horror as the gleaming twins did fall
To earth - those shining beacons, once so mighty, proud and tall.
Returning to the stone and sand from which they once were sprung,
Entombing in their bosom those from whom the life was wrung.
And as we watched a cloud appeared and rose up to the sky -
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But as we gasped and then recoiled from that once awful wave,
We saw a sight that one and all a mote of solace gave.
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Budget Funding Request Form
This form is to be completed by the department budget manager at any point in time when a budget funding need is identified. The purpose of this form is to electronically document all budget needs. The approval of this form does not guarantee a budget increase, it does however guarantee that your identified budget need will be documented in the new budget model and considered for inclusion in the year you designate on the Request Details tab. All budget considerations are dependent upon funding availability and enrollment. If approved budget additions are not able to be funded in the designated year due to limited resources, then the request will automatically roll into the following year and possibly given a higher priority due to delay.
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NGHỆ AN — More than 100 buffaloes and cows have died recently due to hemorrhagic septicemia in Con Cuông and Tương Dương districts, the central province of Nghệ An.
Hemorrhagic septicemia is a severe bacterial disease caused by certain strains of Pasteurella multicoda and is frequently fatal. It primarily affects cattle and water buffalo, but infrequently affects pigs, small ruminants, and other hoof-stock.
The epidemic started in Đồng Tiến Village, Lạng Khê Commune in Con Cuông District.
On September 4, a household in the village discovered that their buffalo had died in the forest. Since then, a number of other buffaloes and cows in the village died. Several households even had five buffaloes dying from the disease.
After receiving reports from residents, local authorities immediately enacted different measures to control the disease. However, local residents often let their animals wander, thus it was difficult to prevent the spread of the disease.
The Con Cuông District People's Committee has banned livestock and poultry being transported out of the district and provided vaccinations for the animals. Local farmers have received more education on preventing the disease.
The Tương Dương District People's Committee on Monday also set up plans to prevent the disease from spreading.
As many as 43 buffaloes and cows died from the disease in the district's Xiêng My Commune.
Kha Văn Ót, vice chairman of the People's Committee, said that the district called on local residents to collect their animals from the forest so they could be vaccinated.
The district has reported the situation to the provincial Department of Animal Health for support and instruction. — VNS


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