text:
102nd over: England 333-6 (Sciver 124, Ecclestone 0) Kapp replaces Sekhukhune and he or she begins off with some pedestrian loosners exterior the off stump. She appears to be like a bit stiff. She wasn't very cellular in the direction of the again finish final evening and he or she was doing plenty of stretching and grimacing this morning. My guess is she's carrying a niggle (alongside her crew's batting on her again) however realises her significance to the trigger right here. Nonetheless, it's a maiden to Sciver who's watchful however rock strong, assembly each block with the center of her bat.
a hundred and first over: England 333-6 (Sciver 124, Ecclestone 0) Proper the place she left off. That's simply pure class from Sciver. Her first ball of the morning, delivered by de Klerk, is pushed again previous the bowler for 4. Simply scrumptious batting.
She's additionally clipping a neat look to midwicekt for a single. De Klerk too full – as she typically was yesterday – and it's straightforward for the England batters to plant their entrance leg and hit by way of the road. Additionally, triple Nelson! Have you ever obtained your foot up?
one centesimal over: England 384-6 (Sciver 119, Ecclestone 0) As a result of Alice Davidson-Richards fell on the fifth ball of Thume Sekhukhune's over, we start this morning with only one ball from the Marcus Trescothick Finish. It's on a very good size and is squirmed to gully by Sophie Ecclestone alongside the bottom.
Good morning everybody! Can't look ahead to this. It's the third day of a Take a look at that has gone a method, then one other, then taken a left flip adopted by a brief proper.
England would be the happier of the 2 because of a 207 run partnership between Nat Scvier – unbeaten on 119 – and Alice Davidson-Richards – out on the ultimate ball of the day for 107.
Anneke Bosch was the choose of the South African bowlers, selecting up 3-59 as she nabbed a trio of quick-fire scalps to depart England teetering at 121-5.
It was a mighty collapse after Emma Lamb and Tammy Beaumont had been untroubled of their opening stand of 65, however Bosch despatched each packing earlier than Heather Knight was inexplicably run-out on the primary ball after lunch. Bosch then nicked off Sophia Dunkley and Nonkululeko Mlaba bowled Amy Jones for a duck.
Davidson-Richards joined her highschool mate Sciver and so they had been simply elegant, driving on the up, pulling with authority and crunching something that had the temerity to float on their pads.
Rain is scheduled however a neighborhood within the know has knowledgeable me we must be OK. Fingers crossed. Catch you in a couple of.


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Aytm Announces Immersive Shopping Experience Reimagined As An Agile Shelf Test
aytm, the leading consumer insights platform for some of the world's most notable brands, creative agencies and marketing consultancies, has announced the launch of their state-of-the-art Agile Shelf Test.
Recommended AI News: Accenture and Icertis Form Strategic Partnership to Help Companies Modernize Contract Management
aytm's Agile Shelf Test simulates in-store and e-commerce shopping experiences allowing respondents to interact with products and make purchase decisions. Brands can now get the feedback they need to drive product innovation and marketing excellence without the costs associated with in-store product testing or unsuccessful product launches. This latest innovation from aytm allows for faster survey design, programming, and analysis—significantly reducing the overall time to insights from weeks to hours.
Immersive Real-World Shopping Experiences
This new Agile Shelf Test allows researchers to easily upload product images, information, and pricing—presenting respondents with a photo-realistic shopping experience. It also comes with a growing library of pre-built shelves that can be utilized to save time, offering multiple renderings of shelf configurations for stores like Target, Walmart, and Costco, and more.
With the release of aytm's Agile Shelf Test, quantifying consumer purchase behavior in an authentic shopping environment has become far more accessible—empowering researchers to discover more actionable insights while spending less time and money.
"For years now we've been listening closely to the industry, registering a lot of interest from our clients in automating shelf test in a purely quantitative way. We've heard from quant experts that automating it will prove impossible. More recently, during the pandemic, we've seen an increased amount of logistical struggles in traditional, in-person qualitative shelf tests and decided to give it a try.
Recommended AI News: Kaltura Extends Longstanding Go-To-Market Relationship With AWS
So we put our heads together to design an Agile Shelf Test to solve the timely challenges of a moment, and to meet the timeless needs of a growing industry; to reimagine a tool that empowers insights seekers around the globe on their way to increasing the market share and optimizing online and offline shopping experience."
– Lev A. Mazin – CEO & Co-founder at aytm
Automation Empowers Agility
The new Agile Shelf Test meets researchers' needs by leveraging automated, yet flexible programming to reduce manual entry and deliver critical shelf placement impact testing. Users simply add their products to the shelf; our auto-flow mode automatically sets product facings just how they want the audience to see them. To specify exact order and mimic a planogram, users can tap into simple aytm logic.
Agile Shelf Test also uses automated analysis to address key questions, including purchase intent, purchase volume, purchase amount, attention span, and time spent finding the product. This new approach empowers more actionable insights surrounding customer purchase behavior, making it the most advanced on the market.
Recommended AI News: Vulnerability In Cisco Security Devices Is Dangerous For Business Processes In Large Companies
[To share your insights with us, please write to email@example.com]

subset: commoncrawl


text:
Launching Next has discovered 5 netflix startups.
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At Shippo, we help over 120,000 merchants grow their businesses by simplifying their shipping process and reducing their shipping costs. Over the years, we've watched our customers grow their business and share their love for Shippo far and wide.
Today, we are launching our Customer Referral Program which will allow anyone to earn up to $500 in rewards to anyone that refers their friend to use Shippo, and to the friend that is being referred! So, if you know friends who could use some help with shipping and want to empower their business to grow, both you and your friend can now earn a reward for doing so! Terms apply.
To learn more about our referral program and to join, click here.
Shippo Customer Referrals In Action
Without a doubt, navigating shipping as an e-commerce merchant is hard. We're the experts in shipping, so merchants can focus on other aspects of their business – such as providing their customers with exceptional products and service.
Take it from Jared Rosenbaum, founder of Wild Ridge Plants: "As a small business, we're doing the work ourselves. We can't be an expert on every logistical thing – the heart of Wild Ridge Plants is ecological restoration, not shipping logistics. Shippo makes it possible for us to focus where we need to."
When Jared and his wife, Rachel, initially embarked on building out a mail-order business, they were immediately faced with challenges that many other e-commerce businesses deal with. If Jared's friend hadn't introduced him to Shippo, he and Rachel would've given up on their mail-order business entirely.
We're thankful that our community shares the Shippo love with others, so merchants like Wild Ridge Plants have the opportunity to grow their sales, reach broader audiences, and adapt their business in a way that gives them more time to focus on what they love.
How The Shippo Customer Referral Program Works
A few important details to take into account for those interested in the program:
- In order to qualify as a referrer, you don't have to be a current Shippo customer. For anyone to be eligible for a reward, the person you refer cannot be a current Shippo customer.
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- Funds will be distributed through a gift card of your choice. Gift card choices vary depending on which country you live in.
Additional terms and conditions apply.
To get your unique referral link to share with friends and family, click here.
We continuously help merchants grow their business with our shipping tools, and we are so excited to have more merchants embark on this adventure with us and grow with us.


text:
I was actually trying to do exactly the same. Thanks for being so thoughtful and sharing your codes.
Hi Guys,
Thanks for the code snippets. I am working on a similar problem to handle COVID lockdown retail consumer data - training on pre-lockdown and then fine-tuning on post-lockdown data. The problem I have is that not only was there a huge gap in the data during the lockdown, but the customers' behaviour appears to have changed post-lockdown. I don't want to throw away all the data from pre-lockdown so I thought transfer learning might be appropriate here. Do you have any update on the above code for fastai2? Or any advance on methods that you could share? I'm pretty new to fastai, and have been using XGBoost mostly since becoming a DS, so learning what I can from you guys
Thanks for sharing the code, what is expected from the cat parameter? I am not sure what to add.


text:
Over the weekend I spent more time with StyleCop, bringing a representative sample of code in line with its recommendations.
Fridays intuition has proven correct - there are a handful of rules that I'll disable, but most of the rules are useful, leading towards more maintainable code.
One frustration I found was the lack of a commandline version - the standard download includes Visual Studio and MSBuild integrations, but no commandline version.
So, I've written one.
As soon as I've finished testing it, will post here as a download with source.


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text: Neil Toronto wrote: > Ka-Ping Yee wrote: >> Hi folks, >> >> I have finally completed a draft of a PEP on rebinding of names >> in outer scopes. I've tried to go back and gather all of the >> (amazingly numerous) proposals -- if i've forgotten or misattributed >> any, let me know and i'll be happy to correct them. >> >> I look forward to your thoughts on it: > > Is there any particular reason this *must* be a Py3k PEP? (Aside from > the fact that we're discussing it on the Py3k list, of course.) Some of > the solutions discussed for historical context would *definitely* be bad > ideas for a 2.x (as would changing the semantics of 'global'), but I > can't see why the solution proposed in the PEP couldn't be done sooner. I think you answered your own question - some of the options up for consideration in the PEP are *not* compatible with 2.x, so targeting Py3k makes for a freer discussion of the possibilities. If the result turns out to be backwards compatible, then we can retarget Python 2.6, but that's actually the case for *all* of the Py3k PEPs (even the backwards incompatible PEPs will likely have elements which can be incorporated into the 2.x series to ease the eventual transition). Cheers, Nick. -- Nick Coghlan | ncoghlan at gmail.com | Brisbane, Australia --------------------------------------------------------------- http://www.boredomandlaziness.org


text:
Best Canopy Tent for Vendors 2022 – Top Picks
We're here to take the headache out of shipping online. We've gone through all of the user reviews and have come up with our roundup to help make your choice easier. With so many options available to consumers, it's more important than ever to have a list that you can trust!
The Best Canopy Tent for Vendors – Our Official Roundup
- Portable Shelter: Steel pop up 10 Feet by 10 feet Instant canopy tent with leg skirts for an added touch of elegance. Serves as a portable canopy cover for outdoor celebrations, weddings, and corporate events weddings
- Includes: 10x10 powder coated steel frame, 210 denier canopy fabric top, carry bag, and rope/spike kit
- Easy set up: Set up is quick with no tools required and can easily be done by one person
- Specifications: Weight – 28 lbs. ; Canopy base measures 10 feet x 10 feet with maximum height to peak of 8'3" at the highest setting; Head Clearance of 5'10" under the valance at the highest setting; Open truss design
- 6 month limited (weather damage is not covered under )
- PATENT PROTECTED DESIGN — Our uniquely designed pop up canopy tent allows you to set up your vendor tent in minutes (large enough to fit 4 - 6 people plus utensils) with minimal assembly required. Our patented folding technique lets you fold away and store in minutes, removing the stress of a regular event tent.
- VERSATILE AND PORTABLE — Set up your mobile vendor booth in many locations with passing trade (zoos, parks, beach, sporting events, markets, etc) effortlessly. One of the lightest options on the market (16.2 lbs) and setup in minutes, your outdoor canopy tent is ready to go with you anywhere.
- DRY ERASE WINDOWS — Write on the PVC windows with wet/dry erase markers to attract customers, advertise your products, and promote sales inside your mobile store. Roll the windows up or down in your canopy tent with sidewalls for full control over the internal temperatures depending on body heat or equipment usage.
- QUALITY MATERIALS — The 10x10 pop up canopy fabric is made from 150D Oxford to provide all-day UPF 50+ UV protection from the sun. Fibreglass ribs help keep the event tent sturdy, with further structural integrity available from the included 12 stakes, 6 sandbags, and 12 guylines.
- ERGONOMIC DESIGN — Easily enter and exit the Avantor pop up canopy tent through the large back entrance door with double sided silicone zippers. The low frame allows for quick access of any wheeled carts or wheelchairs, along with hooks in the middle and 2 large mesh pockets—perfect for storage.
- 【60 SECS EASY SET UP】The COOSHADE canopy tent is designed with fully assembled One-Piece frame in high gauge sturdy metal.No tools needed,seamlessly enables one-person set-up in one minute.Enjoy the shade quickly and easily under the sun.
- 【HIGHLIGHTS AND TECHNOLOGY】1) High quality plastic adjustment,make the canopy in any height you prefer.2)Thicken the steel leg,make the canopy more strong and sturdy.3)The 2 canopy sidewalls can be installed or not according to different occasions, convenient and practical.
- 【SUN PROTECTION】Oxford fabric top with silver coating inside provides 100 sq. ft. of shade with 99% UV protection from the sun.Cools and protects 5 or 6 people with plenty of room for a table,perfect for a variety of outdoor events from sports games to farmers' markets.
- 【PARTS INCLUDED】Fully assembled powder-coated steel frame,oxford fabric silver coated canopy top,2 Removable Side Walls,600D heavy stock wear resistant roller bag,4Xsand bags,8Xstakes and 4Xropes
- 【COMPACT STORAGE and EASY TRANSPORT】Tall canopy but folds down compact, in bag size 53''x9''x9". Vehicle transportation friendly. Fit in the most of back seat. 600D heavy stock wear resistant material, designed with two grip handles for team lift, wheels for roll away alone
- ❥Eurmax Canopy is the most trusted & best selling pop up canopy brand based in the USA. We stock all kinds of accessories and parts for the products we are selling and if you have anything about our products, we are ready to help you.
- ❥10x10 Commercial grade canopy tent frame:(1)Strong full truss structure design(2)Hammertone powder coated finishing,Good looking and rust resistance.(3)The latest thumb lock system,easy to lock and release(4)Three height positions,clearance height from-peak height from 10.5ft,10ft to 11.1ft.Set up and take down easily by 1 or 2 person in minutes without any tools.
- ❥10x10 Canopy tent fabric:CPAI-84 fire retardant certificated 500 denier polyester PU coated to block about 99% UV rays.Stitching lines are all seam sealed to prevent water penetrate from seames to make our canopy tent waterproof.❥The canopy tent roller bag:Eurmax unique L shaped roller bag is oversize designed.Big 2.7"diameter wheels,1680D strong polyester,reinforced handles,Roller bag for easy portability and light transportation. Heavy duty wheels glide smooth.
- ❥The package includes:10x10 Pop up canopy frame + Canopy tent top cover + Canopy tent roller bag + Bonus 4 canopy weights bags.Ez pop up 10x10 canopy for party, parties, picnics, market stall/market trade show or any outdoor events.Top front valance with 4 name banner sleeve to customize and personalize your shelter. Help you attract customers.Eurmax commercial canopy tent suitable for both sunny and rainy days.
- ❥Canopy usage:Cover 4 tables in your garden; cover 3 beach chair on the beach; cover 10 people at the same time for your commercial events and outdoor sports.Search"B00D69RN6Q" to get the matched side walls.
- ◆ Eurmax Canopy is the most trusted & best selling pop up canopy brand based in the USA. We stock all kinds of accessories and parts for the products we are selling and if you have anything about our products, we are ready to help you.
- ◆ 10x10 Ez pop up frame:(1)Strong full truss structure design(2)Hammertone powder coated finishing,Good looking and rust resistance.(3)The latest thumb lock system,easy to lock and release(4)Three height positions,clearance height from-peak height from 10.5ft,10.8ft to 11.1ft.Set up and take down easily by 1 or 2 person in minutes without any tools.
- ◆ 10x10 Commercial canopy tent fabric:CPAI-84 fire retardant certificated 500D polyester PU coated to block about 99% UV rays,Sidewall is 210D.Stitching lines are all seam sealed to prevent water penetrate from seames to make our canopy tent waterproof.◆The rolling storage bag:Eurmax unique L shaped roller bag is oversize designed,it is easy to put frame and top in th bag.Big 2.7"diameter wheels,1680D strong polyester,2 layers fabric sewed,reinforced handles,all these makes the bag long lasting.
- ◆ The package includes:10x10 Pop up canopy frame + 10x10 Canopy top + 3 Removable enclosure sidewalls + 1 wall with door and window + Tent bag with wheels + Bonus 4 Sandbag canopy weights.10x10 Commercial pop up canopy tent for party,parties, picnics,market stall/market trade show or any outdoor events.Canopy top front valance with 4 name banner sleeve to customize and personalize your shelter. Help you attract customers.Eurmax commercial canopy tent suitable for both sunny and rainy days.
- 4pcs 10 1/12ft x 7 5/12ft mesh sidewalls, fitting for 10ft x 10 ft pop up canopy tent, to keep food sanitary for food vendor and offer high visibility for promoting your products
- Breathable Mesh - Dense 16 holes per inch effectively blocks sundry for higher hygiene demand, as well as offers air flowing environment to preserve food
- Convenient Design - 3 Sidewalls with roll-up service windows for you to collect the money or pass your product to customers easily; 1 with a middle zipper for convenient entry and exit
- Wide Application - Perfect for food vendor, booth, tradeshow, fairs, market, family gatherings, picnics, camping
- Warm Tips - 4pcs sidewalls for 1 canopy; 1pcs Overall Dimension(LxH): 10 1/12 ft x 7 5/12 ft (3.08 x 2.25 m)
- Canopy coverage: 10x10FT of shade. Cover 4 tables in your garden; cover 3 beach chair on the beach; cover 10 people at the same time for your commercial events.
- Heavy duty fabric: Durable PU, UV blocker, UPF 50+, 100% waterproof. Suitable for both sunny and rainy days.
- Set up in second: Super easy to set up with only 2 people. Roller bag for easy portability and light transportation. Heavy duty wheels glide smooth. Bonus 4 Canopy Sand Bags, 4 Stakes&Ropes for stable and sturdy use.
- Multiple use occasions: Perfect tent for outdoor sports, event, festival, flea market, party, beach, play ground. (Better check the length of the canopy fit your trunk of the car or not before purchase.
- One year after-sale protection for frame, six months after-sale protection for fabrics and accessories. If you have any issue during using our products, please feel free to contact us.
- ♛Eurmax Canopy is the most trusted & best selling pop up canopy tent brand based in the USA. We stock all kinds of accessories and parts for the products we are selling. We supply not only highest quality product but also excellent after-sale service. Please feel free to contact us if you have any problems, we will always stand behind the product we sold, and will do our best to make you 100% satisfaction.
- ♛Canopy Frame: 10ftx10ft Solid steel frame with straight leg:(1)Strong full truss structure design(2)Hammertone powder coated finishing, Good looking and rust resistance.(3)The latest thumb lock system, easy to lock and release(4)Three height positions for you to adjust to fit your needs.
- ♛10x10 Pop Up Canopy top and sunwall:10 x 10 EZ pop up canopy provides 100 square ft shade. 99% UV protection, fire resistant, Stitching lines are all seam sealed to prevent water penetrating from seams to make the canopy real waterproof. 10Ft removable sunwall attached by velcro give you a quick private space and a lot more shade.
- ♛Backpack Style Roller bag: Eurmax EZ pop up canopy tent backpack style roller bag is easy to carry. The bag is big enough for stocking the frame with the top on so you do not need to mount the top each time before use. The bag is made with 1680D strong polyester, 2 layers fabric, reinforced handles, all these make the bag long lasting.
- ♛The package includes: 1x10Ft Steel Power coated frame, 1x10Ft canopy tent top(The front valance with 4 loops sewn to hang your banner).1x Canopy sunwall,1x Backpack bag and 4 x Stakes.Usage:The Eurmax Smart 10 x 10 pop up canopy tent keeps you from the sun and rain, is ideal for all your outdoor events and recreational use such as small business, craft shows, tailgate parties, picnics, camping, party, BBQ, camping, vendor, market stall/market trade show and etc.
- ✅Strong and Sturdy Frame: 10 x 10ft. Full Truss Structure of powder-coated 1mm thick square shaped legs and super strong cross truss is very sturdy, which can withstand 50 km/h wind the sandbags, ropes. Good looking and rust-resistant.
- ✅Large Space: 10 x 10 Pop Up Canopy with straight legs provides a true 100 square feet shade. Big enough for about 6-10 people to sit under it. Center height is 132 inch. Suitable for market stalls, parties, picnics or any outdoor events. MASTERCANOPY commercial canopy tent is suitable for both sunny and rainy days.
- ✅Great Value: Package Includes: 10 x 10 Canopy, 4 Sandbags, 4 Ropes, 4 Tent Stakes and a Wheeled Bag, which is made of 600D fabric coated with PVC with reinforced handles. Canopy cover is made of 500 Denier polyester PU coated fabric, which is water-resistant and can effectively reflect 99% harmful sun rays.
- ✅Simple and Rapid Setup: Set up in 1 minute in just 3 steps. 1.Take the fully assembled frame with top out of the bag and pull open. 2.Place the fabrics over the frame and extend the legs. 3.Use the thumb press buttons to easily adjust height and then snap into place. No tools required.
- ✅Excellent After-Sales Service: 1 year for free replacements of the frame. 6 months for free replacements of other parts. If it's possible that the product has a manufacturing defect, we're always ready to help you.
- 20% More Shade by the Awning: 10 feet by 10 feet with straight legs and 10'x10' coverage at the top means you have more space with extra big awning: added about 23 square feet of ample cooling shade to your customers or friends. Provide hours of comforts and capture more attention from your customers.
- Easy to Set Up: one person can finish it in a few minute no tools required. Just take the fully assembled frame with top out of the bag, pull open, place the fabrics over the frame,extend the legs and you are done. Height settings at will - Three different height you could set. Peak Height Options: 89.3 inch,93.7 inch, 97.2 inch.
- Sturdy Rust Resistant Frame: Powder-Coated Steel frame with 100% nylon moldel brackets 1 1/4'' thick Square shaped legs, 20% stronger than Most Pop Up Canopy Tent in the market. Withstande 50 KM/h of wind resistance combine 2 Formed rubber handles for lifting 1 formed rubber handle for rolling Reinforced.
- Waterproof Canopy Top and windproof Sidewalls: Canopy materials with 500 Denier Polyester with PU lining for Canopy Top Cover, Heat Sealed Seams,100% Waterproof,CPAI-84 fire retardant certificated and 210 Denier Polyester with PU lining for side wall panels. Multiple velcro tabs with sticky hair to strap around frame legs. Large 2" velcro and zipper to connect side wall to protect from wind.
- A Complete Set of Accessories: 1 x 10ft by 10ft pop up canopy top (100%waterproof), 4 x Sandbags, 3 x 10ft Sidewalls,1 x 10ft door wall, 1x 10ft upgrade awning with hardware. 1 x Roller Carry bag , 4 x Ropes ,4 x Stakes. One year after-sale protection for frame, six months after-sale protection for fabrics and accessories.
What To Know Before Shopping For The Best Canopy Tent for Vendors
Our Preferred Shopping Partner – You'll notice that as you click on the products on our lists that youll be taken to the largest online retailer in the world. We chose Amazon as our product partner because of it's brand recognition, and great customer service. You wont have to worry about getting an inauthentic Canopy Tent for Vendors when you purchase through our website.
Pricing – We always consider pricing, and work to provide you the best seling items, at the best prices, however we do not control the prices of items on our shopping partners. We work to make it easy for you to click through and find the latest, most up to date prices.
Consider Your Specific Application – Make sure that you are shopping for your specific needs. What is best for one person may not always be best for you. Don't let a lower price on an item put you off, if that item has the features and design that are best suited for you.
Ratings and Reviews – Sorting through hundreds of reviews is both time consuming, and taxing! We've already done that, and taken the tough work out of shopping so that you are left with a list of the best selling, best reviewed Canopy Tent for Vendors to choose from. You can also easily click through and see al of the reviews on our shopping partner's website
How To Chose The Right Canopy Tent for Vendors For You
There's a ton of choices for just about anything you shop for, so what should you actually be considering? In addition to the aforementioned attention to your specific needs, there's really only a few considerations – price, quality/dependibility, and the reviews of your peers. If you can find items that meet your needs, are priced in your range, and have reviews that showcase the quality, then you should feel confident in making your purchase!
Is Buying a Canopy Tent for Vendors Really Worth It?
The one thing we can't do, is choose for you. We feel that if an item made one of our lists, it has merit as something that is "worth it", as long as it meets your needs, and fits inside your pricerange. We're here to give you the best possible choices, and while we feel it's definitely worth it, we want you to as well.
Is The Most Expensive Canopy Tent for Vendors Always The best?
We covered a bit of this earlier, and the answer is no, because often, there is no "best", but only a "best" for you! You need to decide which product has the best chance of making your life easier and meeting your needs, regardless of price.
Wrapping Up
Our goal is simply to help you make better shopping choices, and we hope that our list and advice do just that. We are here to empower you, the consumer, with the right knowledge, and the right items to get the job done. We're here to be the expert in your corner and hope to be able to provide you with an excellent shopping experience. If there is anything we can do to make your life easier, please let us know!


text:
Air in Baseboard Radiators
This winter I noticed a faint noise from the baseboard heat in our house (gas-fired boiler with two zones- one for upstairs and one for downstairs). I suspected air in the lines so I bled them out. I've done this quite a bit since we moved in because we've rearranged the locations of the baseboards to facilitate a kitchen remodel. Sure enough, there was air in the pipes. After bleeding the pipes, the faint noise was gone but now when the heat kicks on, I hear water gurgling through the pipes. Again, I figure there's still air in the system so I bleed it again but it doesn't seem to improve the situation. The gugrling goes away about 10 minutes after the heat comes on but the initial noise is pretty anoying.
I've repeated this procedure probably a dozen times over the last week to no avail. I've not noticed any leaks in the system either. Everytime I open the spigots to bleed the system, there's a lot of air. I guess my question is this: is there something basic I should be checking on the system that may be malfunctioning and allowing air into the pipes? Since we've lived in this house, I've completely drained the system and refilled it several times and have never had this much trouble with air in the lines. The system is set up with an automatic fill valve from the city water supply if that makes any difference. I'd appreciate any suggestions. Thanks.
stonebm | | #3
Thanks for the response. If a spiro vent is what I think it is (cylindrical thing about the size of a pill bottle and is threaded into top of expansion tank- it has a cap nut on top that is normally left loose), I have one. And, yes there is an expansion tank.
A few other clues: I've noticed a constant wet spot on the side of the boiler by the pressure relief and the relief valve seems to be a little wet. I'm wondering if it's stuck open a little and is letting water out and air in? I'm also noticing that the 2nd floor is overheating (up to 80 degrees when the set point is 73). The second floor recirculating pump is off so I'm assuming the thermostat and the boiler are talking to each other but I'm still feeling a lot of residual heat coming off the 2nd floor radiators. I'm wondering if there's a big slug of air in the first floor loop and it's redirecting heated water intended for the first floor loop up into the second floor loop. Does that sound possible? I'm almost ready to call in a pro but the DIY part of me is hard to beat down...
AhneedHelp | | #4
After several years of head-scratching and plenty of friendly advice from The Wall (at HeatingHelp.com) along with buying and reading most of Dan Holohan's books, here are some tidbits to pass along from a homeowner with a gas boiler/baseboard system that has been hands-off for 4 years except for the annual thermocouple replacement.
First thing you want to do is a thorough examination of all distribution piping that is running through your house and locate ALL bleeder valves.
Some may be hidden between floors and accessible through a hatch.
Just make sure you know where all the bleeders are.
Air can get trapped and prevent water from circulating through spots that you miss.
Second thing is to MAKE SURE the pressure reducer/automatic feed valve assembly is in good working order, especially if it is left open. If you're not sure of its age or condition, replace it.
(There are two opposing viewpoints on leaving the fill valve open or closed after the system is filled.)
If not, it's kinda tricky refilling the system, bleeding, and setting the system at the correct pressure.
Initial system pressure need to be set during refilling while the system is cold, with subsequent bleeding and topping off the system after several heating cycles.
This is especially so with a steel expansion tank system.
When bleeding air, watch the system pressure and make sure makeup water is introduced.
See if there is a Bell & Gossett Airtrol Tank Fitting on your steel tank, if that's what you have.
This item is a must for easily maintaining the correct air/water level in the tank.
A seeping relief valve can mean the tank is waterlogged and there is no air cushion for the water to expand against.
If you have a steel expansion tank setup (vs. a bladder tank), there should not be a airscoop/bleeder setup.
These are just a handful of suggestions.
However, there's a lot of voodoo modifications and repairs done to boiler systems so nothing's ever cut-n-dry when you're trying to figure out what's going on with any given hotwater heating system.
(I ended up correcting several things that were done wrong when our house was switched to a gas boiler/circulator setup from the original oil/gravity system before we bought our house.)
Are there any under-slab runs of heating pipes ?
If you start asking questions, especially at boards such as The Wall, it helps to first have a good understanding of your current setup (plumbing around your boiler) so it can be clearly desribed and understood by the experts.
If you have a digital camera, picture of your boiler plumbing speaks volumes and can speed up the help process.
I also highly recommend Dan Holohan's books, which were recommended to me by other folks.
Good luck.
stonebm | | #6
Got one lined up for Tuesday morning. I'll post the diagnosis for those interested. Thanks for the suggestions.
stonebm | | #7
An update for those interested. The pressure relief valve was worn out and would automatically release at 20 psi (instead of the designed 30 psi). The service guy said that the 10 psi difference makes it very difficult to bleed air out of the system. The more pressure you can use to bleed the air out, the more effective it will be. So, new relief valve and they also replaced the spirovent (sp?), which are apparently very prone to clogging up after 3-4 years. Works like it always used to now. $311 total damage. I guess I could have taken care of that stuff myself but I didn't know exactly what was wrong until they diagnosed it plus I learned some new techniques for bleeding air out. Thanks again to those who responded to my pleas.


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Phoenix Suns vs Chicago Bulls 2/26/2021 Spread Picks and Prediction
Phoenix Suns vs Chicago Bulls 2/26/2021 – The Phoenix Suns have been creating a great buzz in the NBA and they are battling well at the top four of the NBA Western Conference standings. This team is now on the road and will be going up against the Chicago Bulls who are surprisingly in the playoff picture. This game will be held at the United Center in Chicago, Illinois with NBC Sports Chicago and FOX Sports Arizona putting the game on television at 8:00 p.m. Eastern Time. Both feeds can be viewed through an NBA League Pass subscription. The Phoenix Suns are put as the favorites in NBA Game Odds over the streaking Chicago Bulls.
Phoenix Suns vs Chicago Bulls 2/26/2021
|February 26, 2021 8:00 PM ET
|United Center, Chicago, Illinois
|NBC Sports Chicago | Fox Sports Arizona
|NBA League Pass
Chi-town hoops!
🆚 @chicagobulls
📻 @AZSports & @lamejorphoenix pic.twitter.com/xqCtOcwwUv
— Phoenix Suns (@Suns) February 26, 2021
Phoenix Suns Betting
The Phoenix Suns just got their three-game winning streak snapped by the Charlotte Hornets during their last road game with a score of 121-124. Devin Booker has been named as the replacement player for Anthony Davis in the upcoming NBA All-Star Game and he led the team with 33 points against the Hornets. Joining him in the NBA All-Star Game is Chris Paul who nearly had a triple-double of 20 points, 10 assists, and eight rebounds. DeAndre Ayton also had a notable night with 16 points and ten rebounds. The Suns' record is now at 20-11 and trails the Los Angeles Lakers by two games.
Players to watch: D. Booker SG 27 GP 27 GS 34.3 MIN 25 PTS 0.2 OR 3.4 DR 3.6 REB 4.3 AST 0.8 STL 0.3 BLK 3.5 TO 3.2 PF 1.2 AST/TO 18.42 PER
C. Paul PG 30 GP 30 GS 32 MIN 16.7 PTS 0.5 OR 4.1 DR 4.6 REB 8.6 AST 1.2 STL 0.3 BLK 2.3 TO 2.6 PF 3.7 AST/TO 20.55 PER
D. Ayton C 31 GP 31 GS 31.6 MIN 14 PTS 3.5 OR 8.3 DR 11.8 REB 1.7 AST 0.3 STL 1.1 BLK 1.9 TO 3.2 PF 0.9 AST/TO 18.3 PER.
Chicago Bulls Betting
The Chicago Bulls have pulled themselves up to a stable 7th place in the NBA Eastern Conference because of their three-game winning streak. This team hopes to bring the momentum and a win over the Phoenix Suns will boost their confidence even further. They are just a game behind the New York Knicks with their current record at 15-16. Their most recent win was an overtime thriller against the Minnesota Timberwolves prevailing by six points. Zach LaVine was named in his first NBA All-Star Game and he was able to lead his team with 35 points while dropping five three-pointers.
Players to Watch: Z. LaVine SG 31 GP 31 GS 35.8 MIN 28.8 PTS 0.7 OR 4.6 DR 5.3 REB 5 AST 1.1 STL 0.4 BLK 3.9 TO 2.6 PF 1.3 AST/TO 22.89 PER
L. Markkanen PF 14 GP 14 GS 30.4 MIN 19.1 PTS 0.6 OR 5.5 DR 6.1 REB 0.9 AST 0.6 STL 0.4 BLK 1.7 TO 2.2 PF 0.5 AST/TO 17.38 PER
C. White PG 31 GP 31 GS 33.2 MIN 15.7 PTS 0.5 OR 4.5 DR 5 REB 5.2 AST 0.4 STL 0.2 BLK 2.4 TO 2.5 PF 2.2 AST/TO 11.82 PER.
Phoenix Suns vs Chicago Bulls 2/26/2021 Betting Numbers
Phoenix Suns
Phoenix are 9-2 ATS in their last 11 games.
The total has gone OVER in 5 of Phoenix's last 5 games.
Phoenix are 9-2 SU in their last 11 games.
Phoenix are 5-1 ATS in their last 6 games on the road.
The total has gone OVER in 4 of Phoenix's last 6 games when playing on the road against Chicago.
The total has gone OVER in 8 of Phoenix's last 9 games this season.
Phoenix are 13-4 ATS in their last 17 games against an opponent in the Eastern Conference conference.
Phoenix are 6-1 SU in their last 7 games against an opponent in the Central Division division.
Chicago Bulls
Bulls are 4-1-1 ATS in their last 6 games.
Chicago are 5-1 SU in their last 6 games.
The total has gone OVER in 4 of Chicago's last 5 games at home.
The total has gone OVER in 4 of Chicago's last 6 games when playing at home against Phoenix.
Chicago are 4-1 SU in their last 5 games this season.
Chicago are 4-1 ATS in their last 5 games against an opponent in the Western Conference conference.
Bulls are 1-8 SU in their last 9 games against an opponent in the Pacific Division division.
Chicago are 4-1-1 ATS in their last 6 games played in February.
Phoenix Suns
No Injuries
Chicago Bulls
Otto Porter Jr. SF Back is out indefinitely
Lauri Markkanen PF Shoulder is out indefinitely
Chandler Hutchison SF Leg is out indefinitely
|Phoenix Suns
|Chicago Bulls
|Against the Spread
|Straight Up
|Points per Game
|Points Allowed per Game
|Offensive FG%
|Offensive FT%
|Offensive 3PT%
|Defensive FG%
|Defensive FT%
|Defensive 3PT%
Phoenix Suns vs Chicago Bulls Betting Picks
The Phoenix Suns are just coming in with a lot of weapons in their arsenal with soldiers knowing how to wield their guns. The young Chicago Bulls are the underdogs according to Online Sportsbook and will be the riskier bet to take even if they are coming from a three-game winning streak.
Moneyline: The ML handed to the Bulls for this game is at +165 while the Suns are given a -200.
ATS: Five points on the ATS is in between both teams. Suns are sitting on the -5 while the Bulls are +5.
TOTALs: It is 226 points on the total for both teams to reach. Bulls are going under and the Suns are over.
Score Prediction: 113 – 106, Suns


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How many times we can give cerelac to 7 months baby?
4 to 6 months: 3 to 4 tablespoons of cereal once a day, and 1 to 2 tablespoons of a vegetable and fruit 1 or 2 times a day. 7 months: 3 to 4 tablespoons of cereal once a day, 2 to 3 tablespoons of a vegetable and fruit twice a day, and 1 to 2 tablespoons of a meat and protein food once a day.
How can I give my 7 month old baby cerelac?
Measure 75ml and pour lukewarm water into baby's bowl. Step 3: Add 3 leveled scoops of CERELAC. Step 4: Stir until the cereal is smooth and feed immediately using a clean spoon.
What is a good feeding schedule for a 7 month old?
7 Month Old Sample Feeding Schedule
- 7:00 am – Wake up, milk, solids for breakfast.
- 8:00 am – Free play (floor time, cuddle time with mom, sibling play)
- 9:00 am – Nap time.
- 10:45 or 11:00 am – Wake up, milk, solids.
- 12:00 pm – Free play (floor time, practicing sitting, standing, pulling up, sibling play)
- 1:00 pm – Nap time.
What can I feed my 7 month old baby Indian?
7 Months Indian Baby Food Recipes
|Meal (Breakfast/lunch)
|Snack (Breakfast/evening snack)
|Day 5
|Ragi Apple Halwa
|Mashed Apple pear or mashed apple sweet potato
|Day 6
|Suji Porridge/ Suji Apple Kheer/Suji Banana Halwa
|Mashed Carrot beetroot or mashed banana chikku
|Day 7
|Barley Porridge
|Apple Carrot soup
How much should a 7 month old weigh?
Baby weight chart by age
|Baby age
|Female 50th percentile weight
|Male 50th percentile weight
|6 months
|16 lb 1 oz (7.3 kg)
|17 lb 8 oz (7.9 kg)
|7 months
|16 lb 14 oz (7.6 kg)
|18 lb 5 oz (8.3 kg)
|8 months
|17 lb 8 oz (7.9 kg)
|18 lb 15 oz (8.6 kg)
|9 months
|18 lb 2 oz (8.2 kg)
|19 lb 10 oz (8.9 kg)
What fruits can a 7 month old eat?
Bananas, peaches, mangoes, Sapodilla or Chikoo, kiwis, and papayas are some of the best fruits to start with.
How much solids should a 7 month eat?
Solid food: How much solid food for a 7-month-old? Baby should be starting to get three meals of solid food each day. Depending on the baby, a meal might be as little as a tablespoon or two or as much as four to six ounces (eight to 12 tablespoons) of baby food.
Can I mix cerelac with cow milk?
Hello, Ciws, milk is best avoided until first birthday. … You can start cereals with water,but protein in milk are difficult to digest for a 7 month old.
Which cerelac is best for baby?
CERELAC Rice – Recommended from 4 months and when your baby is developmentally ready to start solid foods. CERELAC Oats – Recommended from 6 months. CERELAC Oats with Prune – Recommended from 6 months.
Can my 7 month old have watermelon?
Luckily, you don't have to wait that long to introduce your baby to watermelon. In fact, watermelon is one of the first foods you can give your little one. The American Academy of Pediatrics recommends introducing your child to solid foods, including pureed fruits and vegetables, at about six months.
How much water should a 7 month old baby drink?
A 6-12 month old baby needs two to eight ounces of water per day on top of the water they get from breast milk/formula. Taking sips from their cups throughout the day will usually get them the water they need.
What can I give my 7 month old for breakfast?
- Option 1: Whole Ancient Grain Baby Cereal.
- Option 2: Mashed avocado.
- Option 3: Avocado and Pea Puree.
- Option 4: Apple and acorn squash mash (pureed apples and squash mixed)
- Option 5: Pureed peaches or soft cooked pears.
What should I do with my 7 month old all day?
10 super-fun activities for 7 month old babies
- Bubbles (and lots of them!) Playing with bubbles is one of the most popular 7 month old baby activities. …
- Nursery rhyme sing-along. …
- Outdoor exploration. …
- Crawling games. …
- Clapping together. …
- Family picture game. …
- Food tasting. …
- Noisy fun.


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Romanian Academy
The Publishing House of the Romanian Academy
ACTA ENDOCRINOLOGICA (BUC)The International Journal of Romanian Society of Endocrinology / Registered in 1938
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Case Report
Capatina C, Baculescu N, Trifanescu R, Stancu C, Badiu C, Ciubotaru V, Coculescu MHyperglycemic hyperosmolar state after transsfenoidal surgery for pituitary adenoma
Acta Endo (Buc) 2006 2(1): 79-89 doi: 10.4183/aeb.2006.79AbstractHyperosmolar hyperglycemic non-ketotic state is a life-threatening emergency manifested by a marked elevation of blood glucose, hyperosmolarity, and little or no ketosis. It most frequently develops in middle-aged or elderly patients, often in the setting of previously mild type 2 diabetes and in the presence of one of the established risk factors (e.g. infection, cerebrovascular accident, myocardial infarction). We present the case of a 48 years old woman with no past history of diabetes who developed hyperosmolar hyperglycemic nonketotic state after transsphenoidal surgery for a large macroprolactinoma. Despite having symptoms (secondary amenorrhoea and galactorrhoea) for many years the patient only had inconsistent medical follow-up and eventually she developed optic chiasm syndrome. She was referred for pituitary surgery performed by transsphenoidal route. After surgery there was marked improvement of the visual signs but few days after intervention the patient presented with polydipsia, polyuria and paresthesiae. Based on laboratory tests that showed a markedly elevated blood glucose level (1088 mg/dl), hyperosmolarity, no acidosis therefore, a diagnosis of hyperglycemic hyperosmolar state was made. With rehydration and insulinotherapy she recovered and the evolution was favourable over weeks with discontinuation of insulin administration. The patient still had high prolactin level after surgery (3060.3 ng/dl) so we also initiated dopamine agonist bromocriptine treatment. In addition to the well known effects of dopamine agonist upon prolactinoma it also has beneficial effects on glycemic control in diabetics (it reduces insulin resistance, both fasting and postprandial plasma glucose levels and HbA1c levels). We discuss the possible explanations of the syndrome and the effects of bromocriptine treatment.
Endocrine Care
Niculescu DA, Botusan I, Rasanu C, Radian S, Filip O, Coculescu MCentral sleep apnea in acromegaly versus obesity
Acta Endo (Buc) 2005 1(1): 79-88 doi: 10.4183/aeb.2005.79Abstract ReferencesINTRODUCTION: Sleep apnea syndrome is a common manifestation of acromegaly. Although the obstructive type of apnea was thought to be predominant there are some reports suggesting that central apneic episodes show a high rate and are related to abnormalities of central respiratory control.\r\nAIM: The present study determines the presence and severity of central sleep apnea syndrome in patients with acromegaly compared with obese subjects.\r\nMATERIALS AND METHODS: 35 consecutive acromegalic patients (min GH (growth hormone) during oral glucose tolerance test (OGTT) 6.6 ng/ml) and 19 obese subjects (BMI=44 kg/m2) were polisomnographically recorded between 10 p.m and 6 a.m. Sleep and respiratory disturbances were manually staged according to standard criteria.\r\nRESULTS: The prevalence of sleep apnea syndrome in acromegaly group was 45.7% (16 out of 35 patients). The median of minimum GH level during OGTT was 8.3 ng/ml in apnea group and 5.16 ng/ml in nonapneic group (p>0.05). In acromegaly group with severe sleep apnea syndrome central apnea rate was greater than 10% in 6 out of 7 subjects with REM sleep and in 7 out of 10 with NREM sleep whereas in obesity group this percent was present in 6 out of 18 (REM sleep), respectively 7 out of 19 (NREM sleep).\r\nCONCLUSIONS: The study confirms the high prevalence of sleep apnea in acromegaly. GH serum level is not an indicator for the presence and severity of sleep apnea. Although the total time of central apnea per hour of sleep did not differ between the two groups, the percent (rate) of central apnea was significantly greater in acromegaly group.1. Laroche C, Festal G, Poenaru S, Caquet R, Lemaigre D, Auperin A. [A case of periodic respiration in a patient with acromegaly]. Ann Med Interne (Paris) 1976; 127(5):381-385.2. Roxburgh F, Collis A. Notes on a case of acromegaly. Br Med J 1886; 2:63-65.3. Grunstein RR, Ho KY, Sullivan CE. Sleep apnea in acromegaly. Ann Intern Med 1991; 115(7): 527-532.4. Pelttari L, Polo O, Rauhala E, Vuoriluoto J, Aitasalo K, Hyyppa MT et al. Nocturnal breathing abnormalities in acromegaly after adenomectomy. Clin Endocrinol (Oxf) 1995; 43(2):175-182. [CrossRef]5. Rosenow F, Reuter S, Deuss U, Szelies B, Hilgers RD, Winkelmann W et al. Sleep apnoea in treated acromegaly: relative frequency and predisposing factors. Clin Endocrinol (Oxf) 1996; 45(5):563-569. [CrossRef]6. Colao A, Ferone D, Marzullo P, Lombardi G. Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 2004; 25(1):102-152. [CrossRef]7. Grunstein RR, Ho KY, Berthon-Jones M, Stewart D, Sullivan CE. Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. Am J Respir Crit Care Med 1994; 150(28. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques, and Scoring System for Sleep Stages of Human Subjects. Washington, DC: National Institutes of Health, 1968.9. American Academy of Sleep Medicine. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22(5):610. Kryger M. Monitoring Respiratory and Cardiac Function. In: Kryger M, Roth T, Dement W, editors. Principles and Practice of Sleep Medicine. Philadelphia: W.B. Saunders, 2000: 1217-1230.11. Dostalova S, Sonka K, Smahel Z, Weiss V, Marek J, Horinek D. Craniofacial abnormalities and their relevance for sleep apnoea syndrome aetiopathogenesis in acromegaly. Eur J Endocrinol 2001; 144(5):491-497. [CrossRef]12. Hochban W, Brandenburg U. Morphology of the viscerocranium in obstructive sleep apnoea syndrome?cephalometric evaluation of 400 patients. J Craniomaxillofac Surg 1994; 22(4):205-213. [CrossRef]13. Hochban W, Ehlenz K, Conradt R, Brandenburg U. Obstructive sleep apnoea in acromegaly: the role of craniofacial changes. Eur Respir J 1999; 14(1):196-202. [CrossRef]14. Herrmann BL, Wessendorf TE, Ajaj W, Kahlke S, Teschler H, Mann K. Effects of octreotide on sleep apnoea and tongue volume (magnetic resonance imaging) in patients with acromegaly. Eur J Endocrinol 2004; 151(3):309-315. [CrossRef]15. Isono S, Saeki N, Tanaka A, Nishino T. Collapsibility of passive pharynx in patients with acromegaly. Am J Respir Crit Care Med 1999; 160(1):64-68.16. Weiss V, Sonka K, Pretl M, Dostalova S, Klozar J, Rambousek P et al. Prevalence of the sleep apnea syndrome in acromegaly population. J Endocrinol Invest 2000; 23(8):515-519.17. Cadieux RJ, Kales A, Santen RJ, Bixler EO, Gordon R. Endoscopic findings in sleep apnea associated with acromegaly. J Clin Endocrinol Metab 1982; 55(1):18-22. [CrossRef]18. Lindgren AC, Hellstrom LG, Ritzen EM, Milerad J. Growth hormone treatment increases CO(2) response, ventilation and central inspiratory drive in children with Prader-Willi syndrome. Eur J Pediatr 1999; 158(11):936-940. [CrossRef]19. Grunstein RR, Ho KY, Berthon-Jones M, Stewart D, Sullivan CE. Central sleep apnea is associated with increased ventilatory response to carbon dioxide and hypersecretion of growth hormone in patients with acromegaly. Am J Respir Crit Care Med 1994; 150(220. Llona I, Ampuero E, Eugenin JL. Somatostatin inhibition of fictive respiration is modulated by pH. Brain Res 2004; 1026(1):136-142. [CrossRef]21. Chen ZB, Engberg G, Hedner T, Hedner J. Antagonistic effects of somatostatin and substance P on respiratory regulation in the rat ventrolateral medulla oblongata. Brain Res 1991; 556(1):13-21. [CrossRef]22. Pedersen ME, Dorrington KL, Robbins PA. Effects of somatostatin on the control of breathing in humans. J Physiol 1999; 521 Pt 1:289-297. [CrossRef]23. Lopata M, Freilich RA, Onal E, Pearle J, Lourenco RV. Ventilatory control and the obesity hypoventilation syndrome. Am Rev Respir Dis 1979; 119(2 Pt 2):165-168.24. Zwillich CW, Sutton FD, Pierson DJ, Greagh EM, Weil JV. Decreased hypoxic ventilatory drive in the obesity-hypoventilation syndrome. Am J Med 1975; 59(3):343-348. [CrossRef]25. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334(5):292-295. [CrossRef]26. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D, Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996; 2(5):589-593. [CrossRef]27. Fruhbeck G, Jebb SA, Prentice AM. Leptin: physiology and pathophysiology. Clin Physiol 1998; 18(5):399-419. [CrossRef]28. Lundberg JM, Pernow J, Fried G, Anggard A. Neuropeptide Y and noradrenaline mechanisms in relation to reserpine induced impairment of sympathetic neurotransmission in the cat spleen. Acta Physiol Scand 1987; 131(1):1-10. [CrossRef]29. Mann K, Benkert O, R?schke J. Effects of corticotropin-releasing hormone on respiratory parameters during sleep in normal men. Exp Clin Endocrinol 1994; 103:233-240. [CrossRef]30. O?donnell CP, Schaub CD, Haines AS, Berkowitz DE, Tankersley CG, Schwartz AR et al. Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med 1999; 159(5 Pt 1):1477-1484.31. Shimura R, Tatsumi K, Nakamura A, Kasahara Y, Tanabe N, Takiguchi Y et al. Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest 2005; 127(2):543-549. [CrossRef]32. Tatemoto K. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 1982; 79(18):5485-5489. [CrossRef]33. Clark JT, Karla PS, Crowley WR, Karla SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 1984; 115:427-429. [CrossRef]34. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 1986; 7(6):1189-1192. [CrossRef]35. Thorsell A, Heilig M. Diverse functions of neuropeptide Y revealed using genetically modified animals. Neuropeptides 2002; 36(2-3):182-193. [CrossRef]36. Nam SY, Kratzsch J, Kim KW, Kim KR, Lim SK, Marcus C. Cerebrospinal fluid and plasma concentrations of leptin, NPY, and alpha-MSH in obese women and their relationship to negative energy balance. J Clin Endocrinol Metab 2001; 86(10):4849-4853. [CrossRef]37. Harfstrand A. Brain neuropeptide Y mechanisms. Basic aspects and involvement in cardiovascular and neuroendocrine regulation. Acta Physiol Scand Suppl 1987; 565:1-83.38. Morton KD, McCloskey MJ, Potter EK. Cardiorespiratory responses to intracerebroventricular injection of neuropeptide Y in anaesthetised dogs. Regul Pept 1999; 81(1-3):81-88. [CrossRef]
Coculescu MVassopressin in intensive care unit
Acta Endo (Buc) 2009 5(1): 93-98 doi: 10.4183/aeb.2009.93
Case Report
Baciu I, Radian S.,Capatina C., Botusan I., Aflorei D, Stancu C., Dumitrascu A., Ciubotaru V., Coculescu MThe p.R16H (C.47G>A) AIP gene variant in a case with invasive non-functioning pituitary macroadenoma and Screening of a Control Cohort
Acta Endo (Buc) 2013 9(1): 97-108 doi: 10.4183/aeb.2013.97AbstractBackground: Germline aryl hydrocarbon receptor-interacting protein (AIP) mutations are found in familial isolated pituitary adenoma syndrome (FIPA) families and in a small number of sporadic pituitary adenoma (PA) patients. Although the tumorigenic mechanisms of AIP mutations are unclear, truncating mutations are considered pathogenic, but missense mutations are difficult to evaluate. p.R16H (c.47G>A) is a controversial AIP variant of unknown significance. Aim: To describe a new PA case associated with AIP p.R16H. Patients and methods: One AIP p.R16H non-functioning pituitary adenoma (NFPA) case identified by mutation sequencing screening of sporadic PA patients; 108 controls were screened for p.R16H. Results: The 38 yrs. old male NFPA patient had no family history of PA and harboured a heterozygous p.R16H variant. The proband and two brothers presented severe intellectual disability. Severe visual impairment was the initial symptom and clinical, biochemical and imaging examination demonstrated a large NFPA invading the right cavernous sinus. After transsphenoidal debulking, the remaining tumor continued growth. One of proband's sisters was negative for p.R16H. Among controls, we identified one heterozygous p.R16H carrier, presenting a thyroid follicular neoplasm. Loss of heterozygosity analysis of the pituitary and thyroid tumors was not performed. Conclusions: We report two new occurrences of AIP p.R16H, associated with a NFPA and with a thyroid tumor. The NFPA patient was young and presented an invasive macroadenoma, features typical of AIP-mutated patients. Because the association between p.R16H and PAs has not been conclusively established, further research of p.R16H is warranted, in view of its implications for AIP genetic testing.
Coculescu M, Mihai RModern Training in Endocrinology in Europe: UEMS and ESE-ECAS
Acta Endo (Buc) 2014 10(1): 97-101 doi: 10.4183/aeb.2014.97
Case Report
Badiu C, Capatana C, Cristofor D, Mircescu G, Coculescu MApparent mineralocorticoid excess in a case of lung paraneoplastic Cushing syndrome
Acta Endo (Buc) 2005 1(1): 97-107 doi: 10.4183/aeb.2005.97Abstract ReferencesSevere hypokalemia is a life threatening event, which triggers a number of therapeutic and diagnostic attitudes. In this paper we present a case of 63 years old man, who presented with progressive lassitude, edema, weight loss. The mild hypertension and hyperglycaemia were treated with spironolactone and diet. Initial evaluation showed severe hypokalemia (1.7 mmol/l), hepatomegalia, hyperplasic/nodular adrenal masses; in addition, he has developed a right middle lobe pneumonia which improved with antibiotics. Referred for the suspicion of hyperaldosteronism, aldosterone values were normal (9.3-9.5 ?g/dl), but ACTH was high (725 pg/ml) and did not suppress (710.8 pg/ml) to high dose DXM, as well as cortisol: basal values 27.78 ug/dl, high dose DXM 35.06 ug/dl, showing an ACTH dependent Cushing syndrome despite lack of suggestive clinical signs. Tumor markers suggested a neuroendocrine neoplasia: carcinoembryonic antigen=101 ng/ml (normal values=0.52-6.3 ng/ml), CA 19-9= 155 ng/ml (N < 33 ng/ml). Further radiological evaluation showed a 3 cm right lobe lung tumour. Despite high potassium supplements and spironolactone, the hypokalemia remained around 3.2 mmol/l, characteristic for an apparent mineralocorticoid excess. Because of aggressive evolution of the lung tumour, he died three months after the initial admission into the hospital. Pathology report showed a lung carcinoma. ACTH immunostaining of the lung tumour was positive and revealed a paraneoplastic secretion.1. Martinez Maldonado Manuel. Approach to the patient with hypokalemia. In: Humes H.David, editor. Kelley?s Textbook of Internal Medicine. Lippincott Williams & Wilkins, 2000.2. Beuschlein F, Hammer GD. Ectopic pro-opiomelanocortin syndrome. Endocrinol Metab Clin North Am 2002; 31(1):191-234. [CrossRef]3. Schrier W Robert. The patient with hypokalemia or hyperkalemia. Manual of nephrology. Lippincott Williams& Wilkins, 2000.4. Davison M.Alex. Hypo-hyperkalemia. Oxford Textbook of Clinical Nephrology. Oxford University Press, 2003.5. Walker BR, Campbell JC, Fraser R, Stewart PM, Edwards CR. Mineralocorticoid excess and inhibition of 11 beta-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome. Clin Endocrinol (Oxf) 1992; 37(6):483-492. [CrossRef]6. Campusano C, Arteaga E, Fardella C, Cardenas I, Martinez P. [Cushing syndrome by ectopic ACTH secretion: analysis of the physiopathologic mechanism of hypokalemia. Report of two cases]. Rev Med Chil 1999; 127(3):332-336.7. Torpy DJ, Mullen N, Ilias I, Nieman LK. Association of hypertension and hypokalemia with Cushing?s syndrome caused by ectopic ACTH secretion: a series of 58 cases. Ann N Y Acad Sci 2002; 970:134-144. [CrossRef]8. Torpy DJ, Mullen N, Ilias I, Nieman LK. Association of hypertension and hypokalemia with Cushing?s syndrome caused by ectopic ACTH secretion: a series of 58 cases. Ann N Y Acad Sci 2002; 970:134-144. [CrossRef]9. Newell-Price J, Trainer P, Besser M, Grossman A. The diagnosis and differential diagnosis of Cushing?s syndrome and pseudo-Cushing?s states. Endocr Rev 1998; 19(5):647-672. [CrossRef]10. Howlett TA, Drury PL, Perry L, Doniach I, Rees LH, Besser GM. Diagnosis and management of ACTH-dependent Cushing?s syndrome: comparison of the features in ectopic and pituitary ACTH production. Clin Endocrinol (Oxf) 1986; 24(6):699-713. [CrossRef]11. Schiller JH, Jones JC. Paraneoplastic syndromes associated with lung cancer. Curr Opin Oncol 1993; 5(2):335-342. [CrossRef]12. Crapo L. Cushing?s syndrome: a review of diagnostic tests. Metabolism 1979; 28(9):955-977. [CrossRef]13. White A, Clark AJ, Stewart MF. The synthesis of ACTH and related peptides by tumours. Baillieres Clin Endocrinol Metab 1990; 4(1):1-27. [CrossRef]14. Wajchenberg BL, Mendonca B, Liberman B, Adelaide M, Pereira A, Kirschner MA. Ectopic ACTH syndrome. J Steroid Biochem Mol Biol 1995; 53(1-6):139-151.15. Kraus J, Buchfelder M, Hollt V. Regulatory elements of the human proopiomelanocortin gene promoter. DNA Cell Biol 1993; 12(6):527-536. [CrossRef]16. Stewart PM, Gibson S, Crosby SR, Penn R, Holder R, Ferry D et al. ACTH precursors characterize the ectopic ACTH syndrome. Clin Endocrinol (Oxf) 1994; 40(2):199-204. [CrossRef]17. Wajchenberg BL, Mendonca B, Liberman B, Adelaide M, Pereira A, Kirschner MA. Ectopic ACTH syndrome. J Steroid Biochem Mol Biol 1995; 53(1-6):139-151.18. Kocijancic I, Vidmar K, Zwitter M, Snoj M. The significance of adrenal metastases from lung carcinoma. Eur J Surg Oncol 2003; 29(1):87-88. [CrossRef]19. Usalan C, Emri S. Membranoproliferative glomerulonephritis associated with small cell lung carcinoma. Int Urol Nephrol 1998; 30(2):209-213. [CrossRef]20. Norris SH. Paraneoplastic glomerulopathies. Semin Nephrol 1993; 13(3):258-272.21. Terzolo M, Reimondo G, Ali A, Bovio S, Daffara F, Paccotti P et al. Ectopic ACTH syndrome: molecular bases and clinical heterogeneity. Ann Oncol 2001; 12 Suppl 2:S83-S87. [CrossRef]22. Shepherd FA, Laskey J, Evans WK, Goss PE, Johansen E, Khamsi F. Cushing?s syndrome associated with ectopic corticotropin production and small-cell lung cancer. J Clin Oncol 1992; 10(1):21-27.23. Abeloff MD, Trump DL, Baylin SB. Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung-assessment of clinical implications in patients on combination chemotherapy. Cancer 1981; 48(5):1082-1087. [CrossRef]24. Pastore V, Santini M, Vicidomini G, D?Aniello G, Fiorello A, Parascandolo V. [Role of the surgeon in the treatment of small cell lung carcinoma]. Minerva Endocrinol 2001; 26(4):263-267.
Images in Endocrinology
Gheorghiu ML, Niculescu D, Iacob M, Coculescu MHands as in acromegaly
Acta Endo (Buc) 2008 4(1): 107-107 doi: 10.4183/aeb.2008.107
Case Report
Fica SV, Popescu L, Ciprut T, Ardeleanu C, Terzea D, Trifanescu R, Coculescu MBeneficial effects of gonadotropin releasing hormone analogs in pulmonary lymphangioleiomyomatosis
Acta Endo (Buc) 2005 1(1): 109-119 doi: 10.4183/aeb.2005.109Abstract ReferencesOBJECTIVE: To report an unusual cause of respiratory failure in a 33-year old Caucasian woman, diagnosed at 26 years with pulmonary lymphangioleiomyomatosis (LAM) and treated with gonadoliberin analogs (aGnRH) four years.\r\nMETHODS: The respiratory failure was diagnosed on functional tests (spirometry, oxymetry, diffusing capacity of carbon monoxide). High resolution chest computed tomographic (HRCT) scan and open lung biopsy with specific immunohistochemistry certified the diagnosis.\r\nRESULTS: The diagnosis of pulmonary LAM was established after one year on chest HRCT and lung biopsy which revealed the proliferation of smooth muscle of pulmonary vessels, positive for actin, desmin, vimentin, estrogen- and progesterone- receptors. Spirometry revealed mixed obstructive and restrictive dysfunction. A correlation between worsening of dyspnea and estradiol peaks occurred during three gestation periods. Despite a short treatment with medroxyprogesterone 10 mg/day and tamoxifen (20 mg/day), the patient?s symptoms and pulmonary function tests worsened. aGnRH treatment improved both symptoms and pulmonary function tests during the first year and was associated with a slow decline in pulmonary function tests and stabilization of the cystic lesions during the following 3 years. The patient did not develop LAM-complications such as: pneumothorax, chylothorax, or hemoptysis.\r\nCONCLUSION: Treatment with aGnRH is effective in slowing the evolution of pulmonary LAM.1. Johnson S. Rare diseases. 1. Lymphangioleiomyomatosis: clinical features, management and basic mechanisms. Thorax 1999;54:254-264. [CrossRef]2. Ferrans VJ, Yu ZX, Nelson WK et al. Lymphangioleiomyomatosis (LAM): a review of clinical and morphological features. J Nippon Med Sch. 2000;67:311-329. [CrossRef]3. Rosai J ed. Rosai and Ackerman?s Surgical Pathology. 9th ed. Mosby. 2004.4. Urban T, Lazor R, Lacronique J et al. Pulmonary lymphangioleiomyomatosis. A study of 69 patients. Groupe d?Etudes et de Recherche sur les Maladies ?Orphelines? Pulmonaires (GERM?O?P). Medicine (Baltimore) 1999;78:321-337. [CrossRef]5. Denoo X, Hermans G, Degives R et al. Successful treatment of pulmonary lymphangioleiomyomatosis with progestins: a case report. Chest 1999;115:276-279. [CrossRef]6. Klein M, Krieger O, Ruckser R et al. Treatment of lymphangioleiomyomatosis by ovariectomy, interferon alpha 2b and tamoxifen?a case report. Arch Gynecol Obstet. 1992;252:99-102. [CrossRef]7. Laverdiere C, David M, Dubois J et al. Improvement of disseminated lymphangiomatosis with recombinant interferon therapy. Pediatr Pulmonol. 2000;29:321-324. [CrossRef]8. Boehler A, Speich R, Russi EW et al. Lung transplantation for lymphangioleiomyomatosis. N Engl J Med. 1996;335:1275-1280. [CrossRef]9. Desurmont S, Bauters C, Copin MC et al. [Treatment of pulmonary lymphangioleiomyomatosis using a GnRH agonist]. Rev Mal Respir. 1996;13:300-304.10. Rossi GA, Balbi B, Oddera S et al. Response to treatment with an analog of the luteinizinghormone- releasing hormone in a patient with pulmonary lymphangioleiomyomatosis. Am Rev Respir Dis. 1991;143:174-176.11. Clementsen PS, Folke K, and Faurschou P. [Lymphangioleiomyomatosis]. Ugeskr Laeger. 1995;157:298-299.12. Chu SC, Horiba K, Usuki J et al. Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis. Chest 1999;115:1041-1052. [CrossRef]13. Bonetti F, Chiodera PL, Pea M et al. Transbronchial biopsy in lymphangiomyomatosis of the lung. HMB45 for diagnosis. Am J Surg Pathol. 1993;17:1092-1102. [CrossRef]14. Logginidou H, Ao X, Russo I et al. Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis. Chest 2000;117:25-30. [CrossRef]15. Matsui K, Takeda K, Yu ZX et al. Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy. An immunohistochemical study. Am J Respir Crit Care Med. 2000;161:1002-1016. Baldi S, Papotti M, Valente ML et al. Pulmonary lymphangioleiomyomatosis in postmenopausal women: report of two cases and review of the literature. Eur Respir J. 1994;7:1013-1016.17. Hu H, Wang W, and Wang X. [Clinical analysis of pulmonary lymphangioleiomyomatosis]. Zhonghua Yi Xue Za Zhi. 2001;81:1256-1260.18. Kaptanoglu M, Hatipoglu A, Kutluay L et al. Bilateral chylothorax caused by pleuropulmonary lymphangiomyomatosis: a challenging problem in thoracic surgery. Scand Cardiovasc J. 2001;35:151- 154. [CrossRef]19. Usuki J, Horiba K, Chu SC et al. Immunohistochemical analysis of proteins of the Bcl-2 family in pulmonary lymphangioleiomyomatosis: association of Bcl-2 expression with hormone receptor status. Arch Pathol Lab Med. 1998;122:895-902.20. Moss J, DeCastro R, Patronas NJ et al. Meningiomas in lymphangioleiomyomatosis. JAMA 2001;286:1879-1881.21. Carsillo T, Astrinidis A, and Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A. 2000;97:6085-6090. [CrossRef]22. Sato T, Seyama K, Fujii H et al. Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis. J Hum Genet. 2002;47:20-28. [CrossRef]23. Yu J, Astrinidis A, and Henske EP. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am J Respir Crit Care Med. 2001;164:1537-1540.24. Inoue Y, King TE, Jr., Barker E et al. Basic fibroblast growth factor and its receptors in idiopathic pulmonary fibrosis and lymphangioleiomyomatosis. Am J Respir Crit Care Med. 2002;166:765-773. [CrossRef]25. Valencia JC, Matsui K, Bondy C et al. Distribution and mRNA expression of insulin-like growth factor system in pulmonary lymphangioleiomyomatosis. J Investig Med. 2001;49:421-433. [CrossRef]26. Evans SE, Colby TV, Ryu JH et al. Transforming growth factor-beta 1 and extracellular matrixassociated fibronectin expression in pulmonary lymphangioleiomyomatosis. Chest 2004;125:1063- 1070. [CrossRef]27. Matsui K, Takeda K, Yu ZX et al. Role for activation of matrix metalloproteinases in the pathogenesis of pulmonary lymphangioleiomyomatosis. Arch Pathol Lab Med. 2000;124:267-275.28. Hayashi T, Fleming MV, Stetler-Stevenson WG et al. Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM). Hum Pathol. 1997;28:1071-1078. [CrossRef]29. Dweik RA, Laskowski D, Ozkan M et al. High levels of exhaled nitric oxide (NO) and NO synthase III expression in lesional smooth muscle in lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2001;24:414-418.30. Johnson SR and Tattersfield AE. Decline in lung function in lymphangioleiomyomatosis: relation to menopause and progesterone treatment. Am J Respir Crit Care Med. 1999;160:628-633.31. Zanella A, Toppan P, Nitti D et al. Pulmonary lymphangioleiomyomatosis: a case report in postmenopausal woman treated with pleurodesis and progesterone (medroxyprogesterone acetate). Tumori 1996;82:96-98.32. Kitaichi M and Izumi T. Lymphangioleiomyomatosis. Curr Opin Pulm Med. 1995;1:417-424.33. Svendsen TL, Viskum K, Hansborg N et al. Pulmonary lymphangioleiomyomatosis: a case of progesterone receptor positive lymphangioleiomyomatosis treated with medroxyprogesterone, oophorectomy and tamoxifen. Br J Dis Chest 1984;78:264-271. [CrossRef]34. Zahner J, Borchard F, Fischer H et al. [Successful therapy of a postpartum lymphangioleiomyomatosis. Case report and literature review]. Schweiz Med Wochenschr. 1994;124:1626-1632.35. Pechet TT, Meyers BF, Guthrie TJ et al. Lung transplantation for lymphangioleiomyomatosis. J Heart Lung Transplant 2004;23:301-308. [CrossRef]
Coculescu MObituary: Colin Ingram
Acta Endo (Buc) 2014 10(1): 118-120 doi: 10.4183/aeb.2014.118
General Endocrinology
Radian S, Bensaada M, Lautier C, Moles JP, Grigorescu F, Gussi I, Badiu C, Nastasia S, Hudita D, Leonte L, Marinescu B, Coculescu MMolecular genetics strategies to identify vasotocin coding sequences in humans: family-specific approach using genomic DNA and fetal tissues mRNAs
Acta Endo (Buc) 2005 1(2): 131-144 doi: 10.4183/aeb.2005.131Abstract ReferencesVertebrate nonapeptide neurohormones constitute an evolutionarily conserved family, involved in vital functions, such as hydro-osmotic balance regulation, reproduction and social behaviour. Two human members of this family are known, vasopressin (AVP) and oxytocin (OXT), with their highly homologous genes closely located on Chr 20p13. Presence of vasotocin (AVT) in man has been suggested, but remains controversial, and genetic evidence is lacking. AVT activity could be explained by the presence of a third distinct gene for AVT or an RNA-processing mechanism involving products of AVP and/or OXT genes. To test the first hypothesis, we developed bioinformatics and experimental approaches using genomic DNA and fetal tissues mRNAs. Family-specific primers for AVT and neurophysin were designed based on CODEHOP strategy and used in our experiments. Results of bioinformatics and genomic DNA experiments (family-specific and Alu step-out PCR) suggest there is no evidence for an AVT gene in the genome. RNA-based techniques 3?-RACE and Family-Specific Domain Restriction Fragment RTPCR provided evidence for new transcript species that could code for AVT. Further experiments will be needed to characterize them. We discuss potential mechanisms of AVT mRNA generation based on AVP and OXT mRNAs, by alternative splicing, heterologous transsplicing or RNA-editing. While all methods we developed proved feasible, current results suggest there is no AVT gene in the genome, but specific mRNAs could be present in fetal tissues. Their full characterization may potentially allow identification of vasotocin mRNA and shed light on a subject of fundamental scientific interest.1. Dale HH. Evidence concerning the endocrine function of the neurohypophysis and its nervous control. In: The Neurohypophysis, editor Heller HH. London: Butterworth?s, 1957, 1-9.2. Dantzer R. Vasopressin, gonadal steroids and social recognition. Prog Brain Res. 1998;119:409-14.3. Bielsky IF, Young LJ. Oxytocin, vasopressin, and social recognition in mammals. Peptides. 2004;25(9):1565-74. [CrossRef]4. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature. 2005;435(7042):673-6. [CrossRef]5. Hoyle CH. Neuropeptide families and their receptors: evolutionary perspectives. Brain Res. 1999;848(1-2):1-25. [CrossRef]6. Sausville E, Carney D, Battey J.The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. J Biol Chem. 1985;260(18):10236-41.7. Pavel, S. Arginine vasotocin as a pineal hormone. J. Neural. Transmission 1978; 13:135-155.8. Coculescu M, Pavel S. Arginine vasotocin-like activity of cerebrospinal fluid in diabetes insipidus. J Clin Endocrinol Metab. 1973;36(5):1031-2. [CrossRef]9. Catrina SB, Coculescu M, Andersson M. A chemical method to isolate hypothalamic nonapeptides by coupling cyst(e)in with bimane. J Cell Mol Med. 2001;5(2):195-7. [CrossRef]10. Badiu C, Coculescu M, Moller M. Arginine vasotocin mRNA revealed by in situ hybridization in bovine pineal gland cells. Cell Tissue Res. 1999;295(2):225-9. [CrossRef]11. Ervin MG, Amico JA, Leake RD, Ross MG, Robinson AG, Fisher DA. Arginine vasotocin and a novel oxytocin-vasotocin-like material in plasma of human newborns. Biol Neonate. 1988;53(1):17-22. [CrossRef]12. Pavel S. Evidence for the ependymal origin of arginine vasotocin in the bovine pineal gland. Endocrinology. 1971;89(2):613-4. [CrossRef]13. Pavel S, Dorcescu M, Petrescu-Holban R, Ghinea E. Biosynthesis of a vasotocin-like peptide in cell cultures from pineal glands of human fetuses. Science. 1973;181(106):1252-3. [CrossRef]14. Rose TM, Schultz ER, Henikoff JG, Pietrokovski S, McCallum CM, Henikoff S. Consensusdegenerate hybrid oligonucleotide primers for amplification of distantly related sequences. Nucleic Acids Res. 1998;26(7):1628-35. [CrossRef]15. <http://blocks.fhcrc.org/blocks/codehop.html>16. Fuentes JJ, Pucharcos C, Pritchard M, Estivill X. Alu-splice PCR: a simple method to isolate exoncontaining fragments from cloned human genomic DNA. Hum Genet. 1997;101(3):346-50. [CrossRef]17. Siebert PD, Chenchik A, Kellogg DE, Lukyanov KA, Lukyanov SA. An improved PCR method for walking in uncloned genomic DNA. Nucleic Acids Res. 1995;23(6):1087 [CrossRef]18. Matz M, Shagin D, Bogdanova E, Britanova O, Lukyanov S, Diatchenko L, Chenchik A. Amplification of cDNA ends based on template-switching effect and step-out PCR. Nucleic Acids Res. 1999;27(6):1558-60. [CrossRef]19. Michel G, Levy B, Chauvet MT, Chauvet J, Acher R. Complete amino acid sequence of goose VLDVneurophysin. Traces of a putative gene conversion between promesotocin and provasotocin genes. Int J Pept Protein Res. 1990;36(5):457-64. [CrossRef]20. Ruppert S, Scherer G, Schutz G. Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence. Nature. 1984 Apr 5-11;308(5959):554-7. [CrossRef]21. Pavel S. Evidence for the presence of lysine vasotocin in the pig pineal gland. Endocrinology. 1965 ;77(5):812-7. [CrossRef]22. Pavel S. Pineal vasotocin and sleep. Environmental Physiology. Vol. 18 in Advances in Physiological Sciences. Proceedings of the 28th International Congress of Physiological Sciences, Budapest, 1980. Obal, F., and G. Benedek, Eds. Budapest: Akademiai Ki23. Coculescu M, Serbanescu A, Temeli E. Influence of arginine vasotocin administration on nocturnal sleep of human subjects. Waking Sleeping. 1979;3(3):273-7.24. Mihai R, Coculescu M, Wakerley JB, Ingram CD. The effects of [Arg8]vasopressin and [Arg8]vasotocin on the firing rate of suprachiasmatic neurons in vitro. Neuroscience. 1994 ;62(3):783-92. [CrossRef]25. Lefebvre DL, Zingg HH. Novel vasopressin gene-related transcripts in rat testis. Mol Endocrinol. 1991;5(5):645. [CrossRef]26. Foo NC, Funkhouser JM, Carter DA, Murphy D. A testis-specific promoter in the rat vasopressin gene. J Biol Chem. 1994;269(1):65.27. Caudevilla C, Serra D, Miliar A, Codony C, Asins G, Bach M, Hegardt FG. Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver. Proc Natl Acad Sci U S A. 1998;95(21):12185-90. [CrossRef]28. Finta C, Zaphiropoulos PG. Intergenic mRNA molecules resulting from trans-splicing. J Biol Chem. 2002;277(8):5882-90. Epub 2001 Nov 28. [CrossRef]29. Mohr E, Peters A, Morris JF, Richter D. Somatic nonhomologous crossing-over between neuropeptide genes in rat hypothalamic neurons. Proc Natl Acad Sci U S A. 1994;91(24):11403-7. [CrossRef]30. Eisenberg E, Nemzer S, Kinar Y, Sorek R, Rechavi G, Levanon EY. Is abundant A-to-I RNA editing primate-specific? Trends Genet. 2005;21(2):77-81. [CrossRef]31. Levanon EY, Eisenberg E, Yelin R, Nemzer S, Hallegger M, Shemesh R, Fligelman ZY, Shoshan A, Pollock SR, Sztybel D, Olshansky M, Rechavi G, Jantsch MF. Systematic identification of abundant Ato- I editing sites in the human transcriptome. Nat Biotechnol [CrossRef]


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Jenna Dewan is an actress and dancer. She started her career as a backup dancer for Janet Jackson, and later worked with artists including P!nk, Missy Elliott, and Christina Aguilera. She is known for her role as Nora Clark in the 2006 film Step Up. Dewan has hosted the reality television shows World of Dance and Flirty Dancing.
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From sardines to anchovies and back in 50 years—Local fisheries part of bigger cycle affecting entire Pacific Ocean
In the late 1930s, California's sardines supported the biggest fishery in the western hemisphere, with more than half a million tons of fish caught each year. By the mid-1950s, the sardines had virtually disappeared. Although fishing pressure may have played a part in this process, new research published in the current issue of Science indicates that the sardines' demise was part of a 50-year cycle that affects not just California, but the entire Pacific Ocean.


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BEACH CITY, Ohio — Authorities in Stark County are investigating after a 29-year-old pedestrian was killed by a vehicle in Sugar Creek Township in Stark County.
On Wednesday at around 7:30 p.m., deputies from the Stark County Sheriff's Office received a 911 call about a car-pedestrian crash in the 8800 block of Justus Avenue Southwest in Sugar Creek Township.
Deputies on scene learned a vehicle traveling southbound on Justus Avenue struck a pedestrian, identified as Bryttny N. Tucker, 29, of Beach City.
She was transported from the scene to Aultman Hospital, where she died from her injuries.
The crash remains under investigation by the Stark County Sheriff's Office and the Canton Metro Crash Team.
Authorities said this is not a hit-skip.
Anyone with information about this crash is asked to call the Stark County Sheriff's Office at 330-430-3800.


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My Entries
My Saved
Affirmation of the Day
I have success in all areas of my life
I focus on what I can change and let go of everything else.
Positive Affirmation
I am incredibly lucky.
I Am Affirmation
There is always a place in the world for my creativity
I am doing a great job.
Why do I have a selfassured confidence?
Question Affirmation *POWERFUL*


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Blouse Cowboy Button Yellow
Prices incl. VAT plus shipping costs
This product is currently out of stock. Enter your email address below to be notified when the product is back in stock.
- Order number: 205-AS1091-YEL-ONE
If a blouse has fashion potential, then our yellow cowboy blouse. They are now available in many designs. The latest version is available with a small button placket. It is a modern and summery blouse with short batwing sleeves. The light oversized style immediately catches your eye. A basic for many styles. The trendy shirt has a round neck and a loose fit. The cowboy blouse is still available in the colors, blue, green, pink and purple.
- Color: Yellow
- Material: 100% cotton
- Made in Portugal
- Short sleeve blouse in oversized cut
- Short-sleeved blouse
- Round neckline
- Patch breast pocket
- Good wearing comfort
- Soft feel
- Smooth button placket
- Elastic insert at the sleeve openings
- Material 100 % cotton
- One Size
- Style tip Sue: An elegant blouse that goes well with our leggings, but also pairs well with skirts
"We women don't always find the right clothes in our heads," said Sue Giers, journalist and PR manager. She decided to create her own fashion in 2016 and founded the label, blog and online shop - SoSUE - with her sister Vanessa. It all started with hoodies, knitwear and jeans.
In the meantime it has developed into a permanent collection. SoSUE doesn't have a season anymore. It suits women who are in the middle of life. Whether job or party, SoSUE fashion is versatile, elegant in every situation and has quality. SoSUE makes you want good style.
We are delighted that you are visiting us. Want even more SoSUE fashion? Then keep looking around the SoSUE shop!


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😊Returns>> Fast refund for any dissatisfaction within 30 days, 100% money-back guarantee.
This week's special event: Randomly selected 20 lucky customers to get double the order product every day. We will send you an email, please remember to check, thanks for your support❤❤❤
Product Size
Because the fabric is thicker, it is recommended to be larger than usual.
🔥Real warm high content cashmere!🔥
🔥Warm, fluffy and thick to keep the body warm and prevent heat loss.FEATURES:
🎉Strong shape, flexibility, suitable for all women wear.🎉
Slim ladies warm Legging show your legs look more slender and keep warm in autumn and winter,a wardrobe esstantial leggings for ladies.
🎉Plus velvet thickening, windproof and cold, lasting warmth.🎉
Warm winter leggings made of high quality material. Ideal for temperatures up to -45 Celsius degrees.
🎉Soft outer fabric, fine and thick, super elastic.🎉
Thermal leggings for women are lined with a soft fleece lining that will keep you warm without adding extra bulk, great to wear in fall and winter leggings.
🎉Care for the skin is not irritating, no damage.🎉
Can be worn with all clothes.
Can be used directly as outer pants with sweater shirts, etc., or as leggings with skirts.
Style:- Casual
Material:Cotton, Cashmere
Length:- Ankle-Length
Thickness:- Warm (Autumn-Winter)/ Cold(Winter-Cold Winter)
Waist type:- High waist
Color:- Black / Gray
1 * Super thick imitation cashmere leggings
⚡Stock sells fast - get yours today!
Due to high demand please allow 5-15 days for your order to be delivered to your address (This applies to all United States and United Kingdom orders).
All other countries worldwide typically take 5-20 days. We apologize for any inconvenience this may cause you; however, we are 100% certain that you will enjoy your shopping upon delivery!
Thank you for being one of our valued customers.


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Northside Roofing is Queensland's largest roofing material supplier and service provider. Since our establishment in 1989, we have been providing the best quality metal roof to commercial and residential customers across Australia.
Restoration and replacement of old, worn roof will give massive facelift to your building, whether you are looking to increase its value for sale, or to have a more appealing, more durable and more heat perserving roof. Our business has more than 20 year of experience in this industry so with us your roof will be in good hands.
We supply all materials needed for roof restoration and will offer new guttering, down pipes, insulation and edge protection. Rubbish will be removed from site as a part of our eco construction practice.
Choose from a variety of colours, visit our website today.


text: Are we scheduling a board meeting during that time? I'm assuming so. I'll be there from Monday through Sat. but I'm teaching on Tue & Wed so the meeting would need to be during the conference itself (Thur/Fri) or in the evening of Tue or Wed if you want me to attend the meeting. I'm also planning to do a talk during the conference but don't know when that might be. So we'd have to work around that too. -Dave -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://lists.owasp.org/pipermail/owasp-board/attachments/20120511/c908615c/attachment.html>


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Prize of the Liselott and Klaus Rheinberger Foundation goes to a Spanish talent
Sergio Moron Basoco was the name of the winner in the Prize of the Liselott and Klaus Rheinberger Foundation, the dressage competition for Young Riders at the CHIO Aachen.
Sergio Moron Basoco and Farnham L – those who don't know the pair yet, should watch out for them in the future. The 20-year-old Spanish rider and his Danish-bred Fürst Rousseau son have already experienced a lot together, have already competed at the European Championships for the Juniors and Young Riders twice, most recently in 2021 in Oliva Nova, where they came fourth in the individual classification and the freestyle. Today, they topped the rankings at the CHIO Aachen. The pair secured themselves the victory with a score of 73.970 percent ahead of the Belgian dressage rider, Amber van den Steen with Fame (73.588) and Germany's Moritz Treffinger with Treffinger's Superstition (72.794).
After the prize-giving ceremony, an overwhelmed Sergio, who lives in Barcelona and who originally wanted to become a show-jumper, said, "I competed here last year already (Fifth place in the individual, third in the freestyle). It is incredible being able to ride here. But to actually win is incredible, simply incredible!"
Moritz Treffinger was of the same opinion, whereby he enjoyed a home advantage, since he is one of the candidates of the CHIO Aachen CAMPUS Programme of Excellence and was able to train at the Soers with Isabell Werth. So, although he was also competing at the CHIO for the first time, he said, "I felt quite at home here." But competing in the Deutsche Bank Stadium is of course something else. "It was simply mega to ride here." He has profited from the CHIO Aachen CAMPUS Programme of Excellence in many ways: "Through the training with Isabell Werth of course, that goes without saying. But also from all of the workshops that are offered in the scope of the programme!"
An interview with Jennifer Gates and Nayel Nassar: "Nothing compares to CHIO Aachen"Welcome to the club – Exclusive NFTs: The CHIO HORSESWhich way to Canada?Goodbye Kempi!Sensation in the Rolex Grand PrixVictory for Team Netherlands in the Boehringer Ingelheim Nations CupChristian Graf von Plettenberg: The voice of the Soers says "Goodbye"Fast, faster, Wilm Vermeir in the Röwer & Rüb PrizeCathrine Dufour's dream comes true in the Deutsche Bank Prize


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Mrs. Geneva Scruggs
April 4, 1925 - July 30, 2017
Mrs. Geneva Scruggs, 92, of Peoria, IL passed away peacefully at 10:42 pm on Sunday, July 30, 2017 at Lutheran Home in Wauwatosa, WI. Geneva was born on April 4, 1925 in Fodyce, Arkansas. She was the daughter of Frank and Mary Ann (Childs)... View Obituary & Service Information
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