text:
Job Description
International Rescue Committee
Sierra Leone Program
4 Off Hill Cot Road, Freetown
Sierra Leone
Tel : +232 (0)76 471 796
Email : email@example.com
Position: Senior IT Officer
Reports to: Senior IT Manager.
Location: Kenema
Grade: 8A
Duration: Four Months Initially (Renewable Annually)
Deadline for applications: 16th August 2022
(Only the applicants who have applied via the IRC Website Cornerstone and shortlisted for interview will be contacted).
Present in Sierra Leone since 1999, IRC supports the Sierra Leonean institutions – government, civil society, community-based organizations, and private sector – to provide improved social services, decrease youth unemployment and mitigate gender-based violence. IRC do this through programs and partnerships designed to improve the life of women, youth, and children by implementing Health, Education, Youth and Women's Protection and Empowerment programming. IRC operates projects in Freetown, Kenema, Bo Kono Kailahun and has a Country Program office in Freetown, a regional Field Office in Kenema, a Field Office in Kono, and Satellite Offices in Kailahun, and Bo.
Reporting to the Senior IT Manager as technical supervisor and The Field Coordinator as Administrative Manager. The Senior IT Officer will provide desktop support services to end users and oversee Networking and system administration services, including computers and end users' applications installations, mobile devices configurations, installation and configuration of printers and other computers peripherals and local domain users' accounts management. A key aspect of this role is ensuring all technology implementations in-country conforms to the global IT policies and procedures hence working closely with Country IT and Regional IT lead is vital.
- Work in collaboration with the Country and Regional IT lead to ensure that end users computers are setup and configured with the IRC standard Operating system and applications versions (IRC image).
- Ensure that computers peripherals such as scanners, printers, monitors, mouse, and others are configured and properly working for all field staff members.
- Work with the Country IT lead to ensure that all users have access to Internet.
- Work with the supply chain person in charge of Assets managements and with Country IT lead to ensure that computers are assigned to users, decommissioned, or disposed following IRC Standard procedures and maintain computers documentation and assets list up to date.
- Aid end users for the configuration and troubleshooting of Microsoft suite products such as Outlook, Word, Excel, and PowerPoint etc.
- Add, update, and remove user accounts in Active Directory based on staff members movement in the Country program, upon approval from Country IT Lead, Field Coordinator or Operation
- Aid end users for their mobile device's configuration on the network and with their professional emails
- Observe and uphold the IRC IT Acceptable Use Policy.
- Act as the IT focal point for the area under your responsibility for the roll out of specific tasks as requested by the Country and/or Regional IT lead.
- Perform other duties as directed by the lead operations coordinator.
Job Requirements:
Education: Bachelor's degree in Computer Science and/or equivalent in relevant field
Technical Skills & Experience:
- At least 3 years' experience in IT Service Management in an INGO
- Strong troubleshooting skills
- Experience in desktop and laptop installation and maintenance
- Good knowledge of Microsoft Operating systems and Applications suite installation and troubleshooting
- Proficiency with client-server environment using Microsoft Server 2008/2012 Active Directory for computers and users accounts management
- Good technical writing/documentation skills
Soft Skills and Competencies:
- Ability to work harmoniously with other staff members in cross cultural contexts.
- Good verbal communication and report-writing skills with the ability to convey information effectively in Country local official language.
- Customer & client centered and service-oriented mind & attitude, and ability to work under pressure and diligently carry out instructions.
- Proven sense of professional discretion, integrity, and ability to manage situations diplomatically and to effective resolution.
Language Skills: Excellent English speaking, listening, and writing.
Computer Skill: Good proficiency in supporting industry standard IT infrastructure and applications
WORK Relationship:
The position will work in the Kenema office but is expected to travel to other offices including Freetown.
Working relationship
The position will work with ICT focal persons in various locations.
Staff will visit non-IRC offices to support external agencies i.e., we provide internet service to Vice President's office in Freetown and staff should be ready to support such services.
Support visitors to IRC office with ICT concern that relate to their formal visit.
Mode of Application:
All applications must be done using the below link and should include a cover letter, updated CV, names of three referees and their active telephone and email contacts, copies of professional certificates and testimonial
Please ensure that all attached files are less than 2 megabytes (2MB) for any one message that is sent.
A copy of your application letter, updated CV, labour card and all other supporting documents should be sent to the NGO Desk Officer, Ministry of Labour – New England or to the nearest Ministry of Labour office nationwide.
Please contact any of our offices captioned below for further information and/or detailed requirements or call on 076-471-796.


text:
By Euro Weekly News Media • 19 March 2015 • 16:05
THE ICC: The most recognised document to have on you while sailing in Europe.
PREVIOUSLY, the Royal Yachting Association (RYA) could only issue the International Certificate of Competence (ICC) to British nationals and residents, and to countries with special permission such as the Netherlands.
However, since December 30, 2014, the organisation can now assign the coveted Certificate to citizens of all countries yet to adopt Resolution 40 – and this includes Spain.
Linda Revill, Principal of recognised RYA Training Centre, Aigua Sea School, says, "Unlike the European driving licence for example, boating qualifications are neither harmonised nor accepted across the EU, and can be the cause of great confusion.
"The ICC however is the most recognised document to have on your person while boating in Europe and reassures the local government of your competence. As a Spain-based RYA Training Centre, it's fantastic news we can now issue this very handy Certificate to non-British citizens including Spanish, Portuguese and Russians – despite them not having signed up to Resolution 40. It will make all our boating lives much easier."
Although not an actual qualification itself, the ICC provides documented evidence that the person in charge of the yacht officially has the necessary skills. The Certificate covers three categories – sail, power (subdivided into under and over 10 metres) and personal watercraft (PWC). It can be issued for coastal waters and for inland should the applicant have passed a European Code for Navigation on Inland Waterways (CEVNI) test.
Lorenzo Vila, Director of easyboats, who partners Aigua Sea School for training purposes, said, "Clients who purchase and charter yachts from us are often asking about skipper training and refresher courses. We make it very clear that their certificates must be shipshape so as not to fall foul of the law, with minimum requirements being a one-day proficiency certificate to pilot a PWC, a two-day Level 2 certificate for a powerboat, a four-day Day Skipper course for a motor cruiser and a five-day Day Skipper course for sailing.
"With Aigua now able to secure an ICC on all of the above, whether you're a British or Spanish citizen, the authorities will be more than satisfied that you're capable and competent."
For more information on RYA Training visit www.rya.org.uk or www.aiguaseaschool.com.For further information on yacht charter, sales and management, contact easyboats on [email protected], telephone 0034 607 608 870 or visit www.easyboats.com. Facebook: https://www.facebook.com/easyboats Twitter: @easyboats LinkedIN: https://www.linkedin.com/company/easyboats. We are also on Google+.
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subset: commoncrawl


text:
Bottle bills were popular this legislative session, with updates and expansions passed or considered in several states.
Bottle bills were popular this legislative session, with updates and expansions passed or considered in several states.
First there was Colorado NextCycle. Then there was NextCycle Michigan. Now, the next NextCycle has landed in Washington state.
This story has been updated.
California's printed paper and packaging extended producer responsibility bill passed the state Senate unanimously June 30 and was signed into law, just before the deadline to pull a plastic-tax measure from November's state ballot.
This story has been corrected.
Nearly a dozen legislators signed a letter asking to remove fiber from California's proposed extended producer responsibility bill, as it undergoes more amendments in the final days before a June 29 deadline.
Two can manufacturers have developed a lease-to-own approach for recycling facilities looking to target UBCs in a more effective way.
With a little help from The Recycling Partnership's Polypropylene Recycling Coalition, a Fresno-based MRF has entered the world of robotics.
Connecticut's attorney general sued Reynolds Consumer Products over the marketing of its Hefty trash bags as recyclable, bringing truth-in-labeling lawsuits to another U.S. state.
A bipartisan group of lawmakers has introduced legislation that would call on the federal government to produce in-depth research on the state of America's recycling and composting systems.
After nine meetings over five months, the Oregon Truth-in-Labeling Task Force has submitted its final report and recommendations to the state legislature.


text:
One Citation
A novel code for numerical 3-D MHD studies of CME expansion
- Physics
- 2009
Abstract. A recent third-order, essentially non-oscillatory central scheme to advance the equations of single-fluid magnetohydrodynamics (MHD) in time has been implemented into a new numerical code.…
Energetic particle spectra in finite shocks: the earth's bow shock
- Physics
- 1981
Ipavich et al. have reported fast particle spectra near the Earth's bow shock that are exponentials in the quantity energy per charge, E/Q. It is shown that this is expected if the fast particles…
Electron heat flux constraints in the solar wind
- Physics
- 1999
Enhanced fluctuations from electromagnetic heat flux instabilities may, through wave-particle scattering, constrain the electron heat flux which flows parallel to the background magnetic field in the…
Ultrahigh Energy Neutrals from Extreme Magnetic Flares
- Physics
- 2003
It is shown that bulk acceleration during reconnection of extremely strong magnetic fields near compact objects can accelerate ions to Lorentz factors of $\sim 10^2 \sigma^{3/5}$ under general…
Particle injection and acceleration at earth's bow shock - Comparison of upstream and downstream events
- Physics
- 1990
The injection and acceleration of thermal solar wind ions at the quasi-parallel earth's bow shock during radial interplanetary magnetic field conditions is investigated. Active Magnetospheric…
Diffusive shock acceleration - comparison of a unified shock model to bow shock observations
- Physics
- 1987
A comparison is made between recent AMPTE/IRM observations of diffuse ions detected upstream of the earth's bow shock when the interplanetary magnetic field was nearly parallel to the solar wind…
Cooling flows in clusters of galaxies
- PhysicsNature
- 1984
Cooling gas in the centre of many clusters of galaxies is compressed and pushed inward by the thermal pressure of the hot, uncooled outer gas. Gravity acts as a focusing agent until the gas has…
Dynamics of Relativistic Reconnection
- Physics
- 2003
The dynamics of the steady state Sweet-Parker-type reconnection is analyzed in the relativistic regime when energy density in the inflowing region is dominated by the magnetic field. The structure of…
A Statistical survey of Ions Observed Upstream of the Earth's Bow Shock'
- Physics
- 1981
The characteristics of 33 diffuse particle events in the energy range from ∼30 to ∼130 keV/Q observed upstream of the earth's bow shock have been determined. The measurements were made with the Ultra…
Thermal Conduction in Clusters of Galaxies
- Physics
- 2001
We estimate the thermal conductivity of a weakly collisional magnetized plasma with chaotic magnetic field fluctuations. When the fluctuation spectrum extends over two or more decades in wavevector,…


text: Referring to [thread=6453]this thread[/thread], the Jeppesen Skybound II linear flash card programmer has worked properly since late 2006. Prior to that, the device would alternately connect and disconnect from the VM. As of Parallels version 4 including today's release 5640, Skybound no longer works. It's back to connecting and disconnecting every couple of seconds as before. I'd appreciate the behavior of version 3 restored for this USB device. OSX 10.5.5, MacbookPro C2D, JSUM v184.108.40.206 build 13104. Windows XP, all updates applied.


text:
Ramsgate Holiday Homes, Beachfront Accommodation4.5 – 10 Guest Reviews
5 Holiday Homes in Ramsgate. Enter dates to see full pricing and availability:
Alomsee 14
Holiday Homes, Self Catering in Ramsgate
Welcome to Alomsee 14,
Alomsee 14 is a modern and beautifully decorated 4 bedroom, 3 bathroom unit that sleeps 8...
Villa Coconut Grove
Holiday Homes, Self Catering, Villas in Ramsgate
Beautiful 4 storey beach Villa with magnificent sea views from each floor. Very tastefully decorated and fully...
Beautiful East
Holiday Homes, Self Catering, Villas in Ramsgate
Looking for the perfect getaway? Book a stay at Villa Ti Amo, offering stunning sea views from the deck. The...
St Estian 1
Holiday Homes, Self Catering in Ramsgate
Welcome to St Estian 1,
St Estian 1 is a modern, beautifully furnished 3 bedroom, 2 bathroom duplex unit less...
The Locker
Holiday Homes, Self Catering in Ramsgate
Welcome to The Locker,
The Locker is a 3 bedroom, 2 bathroom free standing house located on the beach in Ramsgate...
Other listings in Ramsgate
Other Nearby Listings (Within km)
Destinations Related to Ramsgate Holiday Homes
Umzumbe, Melville, Uvongo, San Lameer, Port Shepstone, Margate, Umtentweni, Wood Grange, Shelly beach, Port Edward, Hibberdene, Lawrence Rocks, Salmon Bay, Southbroom, Glenmore Beach
Ramsgate Reviews
Nice, small cozy town, close to the sea..
Had a lovelly time at our accommodation. Beautiful with an amazing view❤😍
Everything about the place I absolutely loved and enjoyed.
Ramsgate has the most beautiful beaches and we love the Blue Lagoon restaurant and Waffle House little complex. The people are friendly even at the local Spar.
Everything was close and convenient in Ramsgate.
Wish we had more time here. It is beautiful and not too rushed (at least out of season).
Beaver Creek coffee plantation, Wagon Saloon and the Waffle House are definite must visits.
Beach and Restaurants.
Surrounding areas, people are friendly and mostly the beach.
Ramsgate is a small and quiet town with so much to do. The beach is clean and have beach markets and restaurants on the beach. I love it! Will never go somewhere else for my holiday. Children are save and easy to keep them busy.
The Waffle House.
More info about Ramsgate
Ramsgate on the south coast of KwaZulu-Natal Province in South Africa is renowned for its wonderful, flat beach surrounded by natural undergrowth and a calm lagoon. The village is located in the Hibiscus Coast region, named after the large colourful flowers that break the greenery. Ramsgate is a popular holiday destination for inland residents and many families arrive here for their annual holiday year on year.
Ramsgate was first inhabited by survivors of the ship Fascadale that wrecked here in 1895. They settled in an area alongside the lagoon and called it Fascadale. The name later changed to Blue Lagoon before residents finally settled on the current name.
Ramsgate experiences over 300 days of sunshine annually, the place has a chilled holiday vibe and the sea is warm and guarded by lifeguards, all the necessary components required for a relaxing seaside vacation.
Top 8 reasons to visit Ramsgate
1. Ramsgate Beach is Blue Flag... Show more
About Holiday Homes
Holiday Homes offer the ultimate in private accommodation. A private home converted for holiday use, you can stay under your own rules and with no outside interference. With all basic amenities they often include wifi, cleaning services and facilities to Dstv. Holiday Homes are fairly common and often affordable means of accommodation. Another great option to consider if you have a family to take care of. Being converted from private homes, you can find them in all shapes and sizes to suit your needs.


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Liverpool, the Capital of Pop, currently not only tops the Premier League in football, but also tops TwentyEA's list of UK cities to operate in for a Landlord.
Whether it is a Budget Home (1), a Family Home (2), or a Lifestyle Home (3) that you are renting out, all three of these categories deliver the best yield for Landlords when compared with any other city in the UK.
The £500 pcm rental for a Budget Home would equate to £6,000 per annum. If we divide this £6,000 rental price in 2019 by the purchase price of the property in 2019 (£83,000), we obtain an annual rental yield of 7.23%. This figure is the highest of any type of housing stock and of any city in the UK.
The chart below compares the annual rental yields for Liverpool by property type. It suggests that Landlords gain a better return through the rental of cheaper housing stock – i.e. the Budget Homes – than they do by investing in Family Homes (which provide the second-best return) or Lifestyle Homes (which provide the lowest returns).
Readers will note that for comparison we have also added the FTSE – All Share Dividend Yield for 2019, which represents an alternative investment in the stock market. As you can see, whatever property a Liverpool landlord invested in in 2019, the return was higher in rental yields than the stock market would have provided in dividend yields.
Currently, Liverpool FC have performed on a higher level than any other league club ever this season and it remains to be seen if Jürgen Klopp's winning ways will continue beyond 2020 and history will recall him as one of the greatest Liverpool managers of all time. After all, he has a big pedigree to live up to.
The only downside for landlord investors in the city is that rental yields (although they are the highest in the UK) are currently falling and on a downward trend. From 2016 to 2019 for example, rental yields in the Budget Homes segment have fallen by 10%.
Which begs the question: "Which city's rental yields are growing?", but that's another article for another day…
TwentyEA are property market specialists and experts in the UK home mover market, providing smart, specific, and intelligent home mover data and insight to help you better understand the challenges of the industry – and crucially, how to apply this knowledge to leverage brand power. If you'd like to know more about your patch, start by requesting a branch performance review with insight you won't find anywhere else.
1 - Typical Budget Home value has been defined as the value of a home in the 25th percentile – i.e. where 25% of homes that were sold in 2019 are cheaper than this value and 75% of homes are greater than this value.
2 - Typical Family Home value has been defined as the median value of a home sold in 2019 – i.e. the middle value of all homes that were sold in 2019 if ranked in order of price.
3 - Typical Lifestyle Home value has been defined as the value of a home in the 75th percentile – i.e. where 25% of homes that were sold in 2019 are more expensive than this value and 75% of homes are cheaper than this value.


text:
Jewelry Buyer in Mountain Park
Get More & Pay Less at Chapes-JPL.
Jewelry Buyer
Jewelry Buyer Mountain Park, GA
Jewelry Buyer Service Cost
High-end jewelry and luxury watches don't go unappreciated, but what do you do when you suddenly find yourself with more pieces than you know what to do with? Whether you inherited luxury jewelry from a late relative or you bought pieces that you never wore, you may find that some pieces are simply sitting in your jewelry box taking up space and collecting dust.
Mountain Park Jewelry Buyer
At Chapes-JPL , jewelry buyer we have a solution for all of your high-end jewelry and luxury watches that you no longer want. We understand that some of these pieces may be hard to part with, especially if you have a sentimental attachment to them. You want to know that even though these pieces may no longer be in your possession, they are still receiving the care and attention they deserve.
Jewelry Buyer Near Me
Selling your luxury watches and fine jewelry has never been easier. At Chapes-JPL , jewelry buyer we have years of experience and we will help make the process of selling your jewelry or watch easy and pain-free. Our team consists of dedicated professionals who understand what goes into not only making a fine piece of jewelry, but also the attachment that you may feel to it.
Best Local Jewelry Buyer 30075
If you are interested in selling your high-end jewelry or luxury watches, then we are here to help! It's easy to go to just any buyer and sell your pieces, but when you sell your jewelry to Chapes-JPL , you have the satisfaction of knowing that your pieces will be well-cared for, and that you will receive a great price.
Price Quote Jewelry Buyer Mountain Park
We also do our best to make the process as pain-free as possible, which is why we developed our easy 3-Step Process so that you can sell your jewelry and watches with ease.
At Chapes-JPL , we accept a wide range of brands. Check out the extensive list of manufacturers that we accept below. From there, all you have to do is get a free quote, wait for our shipping kit, send your old jewelry to Mountain Park, and receive your payment. It's easy! If you're ready, get started with Chapes-JPL today!
- https://www.facebook.com/places/Things-to-do-in-Mountain-Park-Georgia/113021378713794/
- https://www.instagram.com/explore/locations/1493662517607330/georgias-stone-mountain-park/
- https://www.pinterest.com/beverly2012/stone-mountain-park/
- https://www.tripadvisor.com.ph/Attraction_Review-g35283-d108695-Reviews-Stone_Mountain_Park-Stone_Mountain_Georgia.html
- https://www.stonemountainpark.com/
- https://twitter.com/search?q=Mountain%20Park%20Georgia&src=typed_query


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Use this search to find sold properties in ST4.
(If this page downloads too slowly, click the 'Stop' button and then Hide Map)
You can see a list of All Sold Properties in ST4 since 1995
ST4 Property Information
To find maps of ST4 and all other local property information for ST4, please see: ST4 Property Information
To search for sold properties in areas neighbouring ST4, please see: Local Map for ST4
Can't Find Where You Want?
Type in a town or postcode and click the Find button to go to the property search for that location
Local Searches
Or select from the following local searches:


text:
Hello follks,
I have been working here past one year, Just Now reached 600 sales, Really happy to see this round figure hope to get Elite badge next year I would like to thank my brother @SteelThemes, who Motivated me during my hard times. with out him it's not possible to reach 600 sales in 1 year. Thank you bro and thank you all my customers who purchased our products
Hello follks,
Congrats my bro Really Happy for you
Congratulation @JoomlaBuff Good luck for more sales
Congratulations, @JoomlaBuff! Keep it up!
Congratulation brother. It's happening because of your hard work happy to part of it
Congratulations @JoomlaBuff on the milestone. May success continue for you!
Thank you bro
Thank you mate
Thank you mate
Thanks a lot bro, Happy to working with you
Thanks a lot mate
Thank you


text:
With 45 days to the August 9, 2022, polls, the Independent Election and Commission, IEBC says it has finalised the procurement of 14,000 KIEMS kits to aid in the general elections.
However, IEBC chairperson Wafula Chebukati says the commission has not procured ballot papers since they are yet to have the final list of the presidential candidates which will be availed by June 30, 2022.
"We have already procured 14,000 KIEMS kits that will be used in the upcoming elections. This is in addition to the existing 44,000 kits that were used in 2017," he said.
Chebukati also added that they are currently recruiting 300,000 temporary staff who will man the hotly contested general elections.
- Jinxed? Dark past haunts IEBC as Chebukati prepares to exit
- Fact Check: Does IEBC vice-chair Juliana Cherera have social media accounts?
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- Something isn't adding up in Chereramatics
Keep Reading
At the same time, IEBC has stressed that it will use alphanumerical search during the polls and that no voter will be denied a chance to exercise his or her democratic right.
On election malpractice, Chebukati says that the commission has 'no teeth to bite' sighting the recent case against Murang'a Woman Rep Sabina Chege over vote-rigging claims.
"We have no teeth to bite regarding politicians involved in election malpractice because of the court ruling regarding the Sabina Chege case. We can only forward complaints to the Director of Public Prosecutions," said Chebukati.
"We cannot summon them, despite the fact that it's our mandate according to the Constitution. That's why we appealed. We are waiting for the ruling regarding our appeal next week."
In the same breath, the commission faulted judge Anthony Mrima for finding that its committee has no powers to summon politicians before they have been formally nominated and ascertained that they will vie as independent candidates.
IEBC says the judge failed to appreciate that it has the mandate to enforce the electoral code of conduct.


text:
Before you sign on the dotted line, ask these questions
Buying a property that needs a little love doesn't have to be a scary prospect. In fact, a house needing repairs can be a fun opportunity to add a personal touch to the (literal) nuts and bolts.
But before you put down an offer, there are questions you'll need to ask yourself—and a team of contractors—that'll help you make a decision and turn a fixer-upper into your dream house.
1. Why Are You Buying a Fixer-Upper?
First, a question to ask yourself: Why are you choosing a fixer-upper in the first place? Is the home you are interested in located in an ideal location? Is it a historic property? Does it have great bones or other desirable characteristics that newer or updated homes don't? Or is it simply a great deal? Answer these questions first before you take on the project.
2. Is the Work Required Cosmetic or Structural?
Sometimes a house might appear to be in a dire state of disrepair, but most of the damage is actually surface-level and the underlying structure is in good condition.
Repainting and making other cosmetic enhancements can be inexpensive and might not take much time. And with cosmetic upgrades, you can probably live happily on-site while the work is being done.
On the other hand, if the property requires serious structural work such as foundation repair, a new electrical or plumbing system, or any other major renovation, then you need to consider the time involved. In addition, factor in anything else that may affect the pace, the financial investment, and anything else that might affect your ability to live in the home while construction is underway.
3. Does the House Need Major Upgrades to Be Move-In Ready?
Speaking of living in your fixer-upper, if the home is not move-in ready at purchase, that's something to consider before even making an offer. Are you able to live somewhere else while renovations are made? Certain repairs make it difficult or even impossible to live in a property during the job (after all, nobody wants to live in a construction zone).
In addition to reviewing the home inspection reports, you should always get your own local home inspector and contractors you trust. They can check out key structural elements like the foundation and roof to determine the work that needs to be done and approximately how much it will cost.
4. What Can You DIY?
While many home repairs require a professional skill set, there are some home reno tasks you might be able to DIY. Make a game plan (don't forget to consider the necessary time and tools!) and you can save some cash on your overall renovation costs.
That said, hiring a pro is the way to go for jobs like electrical work, plumbing, foundation repair, and anything else that requires substantial expertise and heavy-lifting. All of this should be considered before you commit to buying any property.
5. Are There Any Major Safety Hazards to Contend With?
Asbestos, lead-based paint, and outdated electrical wiring can all add to the cost of renovating an older house. Make sure you're aware of any potential safety issues and get quotes for the associated costs involved with removing these hazards.
6. Are the Current Owners Willing to Make Concessions or Repairs?
If the house you're looking at requires extensive work—or even just minor repairs—consider what you can ask the current owners to do or pay for before signing off on the purchase. If they are motivated sellers, they might just be willing to reduce the price or have the work done themselves. It never hurts to ask!
7. Is the Home a Registered Historic Property?
You may need to ensure that any repairs done maintain the home's unique appearance and design features. For instance, if you buy a property that's a registered historic property or one that's listed on the National Register of Historic Places, you might have to follow guidelines on preserving the historic architecture.
Along with living in a literal piece of history, buying a registered historic home can come with financial perks including tax incentives, better interest rates on loans, or even access to federal, state, or municipal grants.
8. Can You Incorporate Existing Features or Materials Into the Renovations?
One of the main draws of buying an older or historic home: the beautiful design elements you won't find in modern spaces. So when you're remodeling, don't let that charm be lost.
While the kitchen and bathrooms may need some modern upgrades and new appliances, the home's original tile, stonework, or metal fixtures can be salvaged and reused to keep the home's personality alive. Plus, you'll save on material costs!
9. What Are the Potential Costs of Hiring Contractors?
While you may have an idea of what it might cost to replace a roof or fix the cracks in a damaged foundation, it's important to get a clear picture of what, exactly, is required and what you'll pay.
Get estimates from local contractors and bring in your own inspector. Ask for detailed estimates and get the contractor's credentials—they should be licensed, bonded, and insured. If you buy a registered historic home, your pros may need special licenses.
Before you sign on the dotted line, get quotes from a few different contractors, ask to see examples of their previous work, and ask for references to reach out to.
10. Is the Weather or Landscaping a Significant Concern?
If there are gorgeous old-growth trees or shrubbery around the property, take steps to maintain those valuable plants during renovations. Not only do they add beauty and shade to your outdoor space, but these types of trees can also add value to the property.
Weather issues can also affect the timing of home improvements or renovations, so that is something to consider if you are replacing the roof or taking on other big projects that are necessary to make the home liveable.
11. Will Making Renovations to This Home Affect Homeowners' Insurance Costs?
While insurance costs are probably not the first thing you think of when pricing out home improvements, know that some renovations (like a new roof or upgraded kitchen) can increase your homeowners' insurance premiums by causing the value of the home to go up. Adding some features, like a below-ground pool, can also require more insurance coverage.
12. Does the Property's Price Reflect the Amount of Work that Needs to be Done?
If you love a home that needs repairs and the price is both within your budget and accurately reflects the value of the property as-is plus the cost of necessary fixes, then purchasing that particular fixer-upper might be a great choice. However, if you feel like the home is a potential money pit or any of the above questions haven't been satisfactorily answered, then it could be better to move on to a home that better matches up with your needs and goals.


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MotioninJoy, a small program that allows you to use the Playstation 3 controller with all your games, is one of the most popular and comfortable. You can continue your download on the official Motioninjoy DS3 Tool website. You can control the buttons and the behavior of the controller. MotioninJoy is a useful tool for controlling the PS3 controller from your computer. Next, configure your controller.

This is an easy process. MotioninJoy can be downloaded and used without any restrictions. Once the drivers have been installed, you will only need a regular USB cable to connect your Playstation 3 Controller. This amazing set of drivers allows you to play and control all PS3 games from your computer. The best part is that it takes less than 2 minutes to complete. It is a great application for anyone who wants a single-stop solution for all their games. You are already familiar with your Playstation console controller, and you will want to use it on your laptop.

To enjoy the full capabilities of your computer, you will need a PlayStation controller and a USB cable. To use this application, you will first need to install it. MotioninJoy, a simple but effective application, will allow you to use your PS3 controller on any computer. The installation process takes less than 2 minutes. You can download the program and install it in just a few steps. You can use your controller to play games on your computer or other applications that support it.

The application is also useful for making changes on the go. MotioninJoy was recommended to me by a friend. The driver can be installed quickly and the entire setup takes only a few minutes. MotioninJoy has been my favorite application for 8 months. You can check your drivers and contact our support.

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All the necessary dives are included to enable the application to run all updates. Auto-update is a feature that allows the application to automatically update itself whenever there is an internet connection. The Motioninjoy DS3 Tool installation is simple. After you have started the DS3 Tool, you will need to plug your controller into the computer to pair it.

Next, click the Enable button. Once the setup is complete, you can use your controller in any game as you would with an official Microsoft controller. You can verify that the connection is active by pressing the Vibration Test button. The controller will vibrate to confirm that it has been properly paired. The application will then detect the controller that you have just по этому сообщению. You just need to click on the function that /31603.txt want and it will be done in minutes.

This simple app will allow you to set up the buttons and control how your controller interacts with your computer. Many gamers prefer controllers to the traditional mouse and keyboard. This can allow them to have more control over their characters, especially when there is a lot of moving around. The PS3 controller was one of the best out of all the new consoles. This app is a result of hard work by our team.

We are proud of the results. To build trust among our customers, we have made MotioninJoy available for free. The official MotioninJoy app can be downloaded from the link below. Drivers motioninjoy windows 8 download free be easily installed. April is a technical writer at Driver Easy.

She writes about various tech issues such as game and Windows problems. She is a Microsoft Certified Professional and focuses on Windows system motioninjoy windows 8 download free and daily tips and techniques. You may be interested in a new PS3 controller. You are in motioninjoy windows 8 download free right place. Your email address will not be published.

Motioninjoy windows 8 download free my name, email, and website in this browser for the next time I comment. Get Into Pc. October 5, Password Leave a Reply Cancel reply Your email address will not be published. Copyright Getintopc.

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More MotioninJoy Gamepad tool 0. For some reason under Windows 8 standard pairing procedure with PS Move controllers doesn't work. Herdprotect anti-malware scanner is a fast and free windows desktop program which detects malicious threats, spyware and adware in less than 60 seconds by utilizing 68 industry anti-malware scanners.

Okay so i'm recently playing the game and as a fps player myself normally call of duty i much prefer to use my ps3 controller rather than the built-in controller settings on the keyboard. This is the official website of motioninjoy and here you can get the latest version of motioninjoy v0.

You can easily download the folder. Using motioninjoy you can use your ps3 controller with motion sensor to emulate the xbox gamepad.

Explore 10 apps like motioninjoy ds3 tool, all suggested and ranked by the alternativeto user community. This process can download software or the motioninjoy ds3. Hello all, as some of you will have already noticed, for the last couple of weeks, some threads and posts are seemingly garbled with random characters and symbols which makes reading virtually impossible or at the very least unpleasant.

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This works in most cases, where the issue is originated due to a system corruption. Give internet access to use my controller. Unfortunately, motioninjoy was a proprietary piece of software that turned into malware over the years.

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"It does everything we wanted it to do."
"There are many valuable features in New Relic APM. We developed some software applications and we are able to monitor the errors very easily. Their log security retention is very good."
"The stability of New Relic APM is very good."
"The simplicity of the dashboard is very good."
"The breakdown of the response time of different components and getting in-depth details of the slow component are the most valuable features. It is easy to use, and it gets the job done."
"We like the performance of the product."
"The most valuable feature is the ability to receive in-depth information about applications. It can detect a lot of important information."
"Working with the solution is very easy. It's user-friendly."
"DX allows you to customize and gives you a high degree of control."
"The most valuable feature of OmniPeek was the ability it gave us to see the connection procedure."
"New Relic APM can improve the information when we dig deeper to check a problem. There should be more detailed information provided."
"How granular I could go down at looking at certain data, especially related to the operations, is limited."
"They should bring the pricing down to be more competitive."
"The older view is much better than the new view that they have. We'd like to go back to that previous version. The user interface just isn't as nice as it used to be."
"It would be nice if there were pre-made dashboards."
"The solution is quite expensive."
"The solution could improve by having more network monitoring features, such as for all the infrastructure."
"There has been some problem with the agent, and it is just not working well. It is not able to record information with the application server. They have been able to fix the issue, but it took quite a long time. This is the main issue in the APM products and also in New Relic. The mobile application monitoring has been pretty difficult to set up and also quite expensive. It should be a little bit easier and cheaper. Because it is pretty difficult and expensive, many customers don't take it."
"DX SaaS is a latecomer to the APM market. Some things that are straightforward in Dynatrace are complicated in DX. For example, upgrading the agents is a seamless process in Dynatrace, but it's a pain in DX SaaS. You should be able to upgrade in the Application Command Center. However, it is not working correctly."
"I would like to see the tool work in an open environment the same as how it does in a closed environment."
Earn 20 points
New Relic is a software analytics and application performance management solution that gives users in-depth data visibility and analytics. By going right to the source, the code, New Relic enables users to develop quicker software, build improved products,and consistently impress their customers. Data tells a story and New Relic interprets what it is telling you.
Dx SaaS is a solution whose goal is to ensure that businesses and organizations can monitor and manage the way that users experience their applications. This solution contains many powerful tools that are designed to give administrators the maximum amount of control over the experiences that clients have when employing their applications. Organizations and businesses can rest easily and ensure that the product they put out into the world is always being watched for potential issues that will be resolved proactively and quietly.
Dx SaaS Benefits
Some of the benefits that come from using Dx SaaS include:
Dx SaaS Features
When users choose to employ the DX SaaS solution, they gain access to many different capabilities. These features include:
Reviews from Real Users
The DX SaaS solution enables companies and organizations to take charge of the digital experiences that their customers receive. It is designed in a way that empowers these companies to truly monitor their applications and maintain a positive user experience. DX SaaS recognizes that applications can be run on any number of platforms. As a result, solutions that monitor and analyze applications need to be capable of handling a wide variety of platforms. This is one of the considerations that the solution's designers made integral to its design.
Administrators can leverage DX SaaS to spot potential issues before they can become problems for the users of their applications. DX SaaS has metrics that can provide application administrators with important insights. Patterns and areas where trouble can arise are immediately exposed so that administrators can take the steps that are necessary for the applications to run smoothly.
A consultant at a technical services company writes, "It supports numerous platforms." Furthermore, they add, "The CA APM blaming metrics are quite useful in identifying a potential issue."
Omnipeek is a top-rated suite of network analytics software that offers full transparency and trusted forensics for immediate resolution of application and network performance anomalies and security issues. Omnipeek is part of the LiveAction family of quality trusted products. They specialize in packet intelligence with adaptable workflows and complete visibility throughout numerous network segments to facilitate a better understanding of network performance and dependability concerns in real time.
Omnipeek combines intuitive geolocation, usability, security, and performance to deliver a robust user experience that facilitates immediate discovery and problem-solving of wireless and wired networks.
Omnipeek is user friendly and offers many different intuitive dashboards, display options, graphs, peer maps, and packets. There are several different capture options, such as TCP dump, multiple adapters, local captures, and Capture Assistant. Omnipeek integrates well with Snort and Suricata intrusion and detection prevention solutions, allowing users to import events easily. The comprehensive analysis tools, such as Expert Flow Analysis, Web Traffic Analysis, Multi-Segment Analysis, and Local File Analysis combine to make Omnipeek a solid, complete solution.
Omnipeek is effective for small offices to large enterprise data centers.
Omnipeek Benefits
Omnipeek Features
DX SaaS is ranked 32nd in Application Performance Management (APM) with 1 review while OmniPeek is ranked 43rd in Application Performance Management (APM) with 1 review. DX SaaS is rated 7.0, while OmniPeek is rated 7.0. The top reviewer of DX SaaS writes "It's highly customizable but lacks many features of available in competing solutions". On the other hand, the top reviewer of OmniPeek writes "Easy to use solution but needs to improve its level of performance". DX SaaS is most compared with Zabbix, DX Unified Infrastructure Management, Dynatrace, Nexthink and Splunk, whereas OmniPeek is most compared with SolarWinds NPM, Colasoft Capsa, Nmap, TruView and LiveAction LiveNX.
See our list of best Application Performance Management (APM) vendors.
We monitor all Application Performance Management (APM) reviews to prevent fraudulent reviews and keep review quality high. We do not post reviews by company employees or direct competitors. We validate each review for authenticity via cross-reference with LinkedIn, and personal follow-up with the reviewer when necessary.


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It's been pretty chilly here lately, at least for our part of the world. And this morning we woke up to a dusting of snow!
My Blog List
Thursday, February 24, 2022
An Early Morning Surprise!
9 comments:
- New Release Books said...
Beautiful spring. Love the color.
- February 24, 2022 at 1:38 PM
- Pointy Little Sticks said...
The snow looks so pretty.
We've been getting little spits of snow all day. Tonight it is supposed to be very stormy.
I will have daffodils soon. They are starting to poke up through the mulch.
- February 24, 2022 at 1:39 PM
- Debbie said...
I love those little daffodils. Mine have just started to peek their heads out and I'm afraid this cold snap might not be the best thing for them after a week of warm temps. It is still February and I hate to say it but I just might like another small dusting of snow before spring.
- February 24, 2022 at 2:24 PM
- Wanderingcatstudio said...
Love your daffies! I bought some hyacinths and tulips today!
- February 24, 2022 at 6:38 PM
- Betsy said...
Beautiful daffodils! We had snow flurries most of the day before it started snowing in earnest just before dark. I'm hopeful that it will be gone in just a few days as temps in the 60's are predicted for next week. Right now it's 1F with a much lower windchill. Brrrrr. I'm ready for spring. I would love spring for all year round. :-)
- February 24, 2022 at 9:56 PM
- karen said...
thank you for the cheerful pot of daffodils, so so pretty!
- February 25, 2022 at 5:18 AM
- kathy b said...
you promise? We are under 4 new inches of snow. But the sun is out and I am sitting 1ike a cat, in the sunshine. I'm trying to make good use of the indoor knitting time that I don't get when I am working the garden in Summer. Just one day in the 70s wou1d be such a comfort!
- February 25, 2022 at 7:59 AM
- Tired Teacher 2 said...
Jonquils are the harbingers of Spring! Very pretty.
- February 25, 2022 at 8:40 AM
- Delighted Hands said...
The snow doesn't look so bad from over the daffodils!
- February 27, 2022 at 4:11 AM


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Happy Birthday Richard Barber!
October 29, 2021
This week sees a landmark birthday for Dr Richard Barber, co-founder in 1969 of the Boydell Press which in time merged with Derek Brewer's imprint to form Boydell & Brewer. All of… READ MORE
October 29, 2021
This week sees a landmark birthday for Dr Richard Barber, co-founder in 1969 of the Boydell Press which in time merged with Derek Brewer's imprint to form Boydell & Brewer. All of… READ MORE
October 27, 2021
Winner of the 2020 ALA Book of the Year Award – Scholarship Writing Spatiality in West Africa examines the ways in which space and spatial structures have been constituted, contested and re-imagined… READ MORE
October 25, 2021
Agriculture carries with it the impression of tradition, knowledge and skills as old as the land itself. But in order for farmers to meet our needs, agriculture has always had… READ MORE
October 20, 2021
Hedley Twidle discusses his publication: Experiments with Truth: Narrative Non-fiction and the Coming of Democracy in South Africa from James Currey African Articulation series. This article was originally published in the African Griot. Experiments with Truth is a… READ MORE
October 18, 2021
Just as their collection does in the year of his 70th birthday, the editors of Contesting Orthodoxies pay tribute to Diarmaid MacCulloch and the example he has set in his teaching and writing. … READ MORE
October 15, 2021
Boydell has long published on all aspects of Ireland's history and literature – we even publish a delightful travel guide for visitors – and the last year or so has… READ MORE
October 11, 2021
The countdown to the next volume of the African Griot is well and truly on! Today we share a post from John C. Hawley who was the guest editor of ALT… READ MORE
October 6, 2021
Black History Month is celebrated every October in the UK, highlighting experiences, achievements & contributions that are too often overlooked. At Boydell we are proud to publish books that honour… READ MORE
October 4, 2021
The Nigerian writer Chimamanda Ngozi Adichie in her widely circulated TEDGlobal talk of 2009 drew attention to what she called 'the danger of a single story'. Interrogating dominant generalising narratives that reinforce stereotypes about… READ MORE


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Kadena, the hybrid proof-of-work (PoW) blockchain that combines a layer 1 public chain protocol with a layer 2 network, has announced the launch of a gas-free decentralized exchange (DEX) known as Kaddex.
The project says its team has undertaken a "rigorous, multi-stage review" of the code, launched a public build of Devnet, and opened a bug bounty program in partnership with Immunefi to incentivize general improvements to Kaddex.
Kaddex v1
Through Kadena's intertwined chain structure (KDA), Kaddex offers a system of staking and liquidity pooling without gas which "will always remain free". The project claims that, along with gas-free transactions, Kadena's scalable blockchain will ensure quick and secure settlement.
Since everything, from liquidity to supply, from pricing to swapping, is done entirely on the chain, there is no need for the intervention of oracles outside the chain. Additionally, Kaddex represents the only multi-protocol DEX with native decentralized bridges, meaning users can access value through a single platform.
KDX stakers will earn 0,05% on all swaps that take place on Kaddex, allowing holders to earn passive income while participating in governance.
Indeed, Kaddex's decentralized autonomous organization (DAO), which focuses on ecosystem development, plays a key role in controlling the parameters of individual pools. Its purpose is to establish community ownership of the ecosystem, allowing members to lead the development of the platform.
Liquidity extraction program
A distinctive feature of the newly launched DEX is the implementation of a more modern version of the automatic market maker (AMM) Uniswap v2, using the Pact programming language.
A liquidity extraction function has been added to the code to incentivize users to act as liquidity providers (LPs). Specifically, LPs will have two options: claim 0,25% swap fees or KDX token rewards with a programmatic booster.
In this way, Kaddex's cash extraction program is designed to attract cash through the distribution of native KDX tokens, which the project says will "generate lucrative boosters for early LPs that will decline non-linearly" over time.
The rewards of the network represent 40% of the total offer of KDX, which could increase the activity of the DEX in the long term, ensuring a fair and decentralized distribution for the benefit of the participants. From a cap of 1 billion KDX, Kaddex will distribute 400 million tokens (40%) to liquidity providers. However, Kadena will not mint extra tokens to ensure that the increased rewards "don't go at the expense of KDX holders" when inflation is taken into account.
This means that when users withdraw cash and opt for enhanced KDX rewards, Kaddex smart contracts use the rewards accumulated by participants (funded by 0,25% trading fees) to buy the equivalent value of KDX on the market, and the delta between the standard rewards and the multiplier is coined by the network rewards.
Other noteworthy developments foreseen in the Kadena roadmap include a push towards further public listings in the US and around the world, as well as the development of an infrastructure for the lending platform.


text:
WEST LAFAYETTE, Ind. – Insignum AgTech and Verility Inc., two companies founded by Purdue University alumni, each received $100,000 from the Purdue Ag-Celerator, an agricultural innovation fund.
Insignum AgTech creates plants that warn growers of infection at an early stage so crops can be protected. Founder and CEO Kyle Mohler said plants turn purple before a pathogen can be identified, providing growers with information to fight the disease.
"Ag-Celerator's investment is a wonderful validation of our progress over the past few years and confidence in our trajectory," Mohler said. "We at Insignum are excited to have Purdue Foundry join our seed round, which will propel our product development in corn and allow us to begin developing technology for other crops.
Verility Inc. is a global animal health platform providing fertility testing products. Co-founder and CEO Liane Hart said the products enable breeders and livestock producers to accelerate reproductive performance through accurate, simple and cost-effective analysis by predicting the ovulation phase and assessing sperm quality at point of service.
"Ag-Celerator's $100,000 will allow us to finalize our ovulation proof-of-concept studies planned throughout the first half of 2022," Hart said. "It's an honor to be selected for this award, not only as CEO of Verility, but also as a Purdue alumnus. We appreciate the recognition by the esteemed jury of the significant and successful results we have achieved throughout our startup journey. This opportunity definitely allows us to move forward faster, creating more value for our business."
Ag-Celerator, established in 2015, is a $2 million innovation fund designed to provide essential seed-stage support to Purdue innovators who bring Purdue's patented intellectual property or "know-how" technologies to market. from Purdue.
The fund is managed by the Purdue Foundry, with assistance from the Purdue College of Agriculture, the Purdue Research Foundation Office of Technology and Commercialization, and the agricultural industry.
"The College of Agriculture is dedicated to creating a culture of innovation and entrepreneurship among students, faculty, staff and alumni," said Bernie Engel, senior associate dean for research and Higher Education. "Applicating to Ag-Celerator provides a tremendous opportunity as well as inspiration for these groups, and the awarding of these generous grants brings award winners that much closer to achieving the impact envisioned."
Riley Gibb, director of business development at Purdue Foundry, said, "There are many high-quality entrepreneurs bringing Purdue-related startups to market. These companies, including recipients of Ag-Celerator investments, are already making an impact in plant and animal science."
In August, Ag-Celerator eligibility was opened to startups in all fields of agriculture. Previous recipients of Ag-Celerator investments include AkanoCure Pharmaceuticals Inc., Heliponix, JUA Technologies International LLC, Karyosoft LLC, Krishi LLC, LeafSpec AgTech, Ongenia LLC, Phicrobe LLC, Progeny Drone Inc., Rogo Ag LLC, VinSense LLC and ZeaVaxx.
About the Purdue Foundry
Writer: Steve Martin, [email protected]
Sources: Bernie Engel, [email protected]
Riley Gibb, [email protected]
Liane Hart, [email protected]
Kyle Mohler, [email protected]


text:
PARIS (AP) — French President Emmanuel Macron spoke with Russian President Vladimir Putin on Friday about his concern for a Ukrainian filmmaker who is on a hunger strike in a Siberian prison.
Macron urged the Russian leader to find a humanitarian solution since Oleg Sentsov's health "seems to be dangerously deteriorating," according to a statement from the president's Elysee Palace office.
Macron made several proposals, and Putin pledged to respond to them and to release information about the condition of Sentsov, who was on his 89th day without food Friday. Details of the proposals were not provided.
The filmmaker, an opponent of Russia's 2014 annexation of Crimea, was given a 20-yaer prison sentence in 2015 for conspiracy to commit terrorism, a crime he denies.
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He says he and 64 other Ukrainians imprisoned in Russia are political prisoners and is demanding their release.
Sentsov's lawyer, Dmitry Dinze, said after visiting him Tuesday at a prison on the Yamal Peninsula in Siberia that Sentsov has anemia and a slow heartbeat.
In their telephone call, Putin and Macron also discussed the necessary conditions to ensure the safe and voluntary return of Syrian refugees to their homeland.
The Kremlin said they shared a high assessment of their nations' joint humanitarian operation in Syria last month, the first between Russia and a western country. The Russian-French operation distributed aid to residents of the former rebel enclave of Eastern Ghouta.
A Kremlin statement said Putin emphasized the importance of the international community helping to restore Syria's infrastructure and to promote the return of Syrian refugees who fled the country since its civil war started in 2011.
The Kremlin noted that the two leaders discussed other issues, but did mention Sentsov.


text:
Greta's World
How one Swedish teenager armed with a homemade sign ignited a crusade and became the leader of a movement
How one Swedish teenager armed with a homemade sign ignited a crusade and became the leader of a movement
Climate activist wasn't tested but said symptoms came on after trip through central Europe
The environmental activist calls for climate action while addressing attendees at the World Economic Forum in Davos, Switzerland
"Happy birthday/to Greta, who stood today,/as every Friday, refusing/to be neutral"
Greta will follow young climate activist as she helps plan international school strike
Daily Show host says president bullying 16-year-old climate activist is like if FDR roasted Shirley Temple for her dance moves
Thunberg, having demonstrated she's better at climate science than the president is, proves she's also better at Twitter
People are waking up to the climate crisis, but two sobering reports this week are a reminder of the enormity of the problem
Climate activist discusses making small changes in own life, inspiring global movement
Suaka drummer John Meredith explains how he dared to make a metal meme out of the Swedish climate-change activist's UN speech
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Stunning Custom Sculptural Modern Tiger Print 22-Karat Gold Leaf Chair
$2,80025% Off
A single brilliant modern 22-karat gold leaf tiger print chair. Freshly upholstered in luxurious Clarke & Clark velvet, circa 1950s.
- Attributed toBaker Furniture Company (Manufacturer)Tommi Parzinger (Maker)
- DimensionsHeight: 27 in. (68.58 cm)Width: 30 in. (76.2 cm)Depth: 27 in. (68.58 cm)Seat Height: 17 in. (43.18 cm)
- StyleModern (In the Style Of)
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- Date of Manufacture1950s
- ConditionReupholstered. Refinished. Wear consistent with age and use.
- Seller LocationHouston, TX
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September 1973
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Clinical Science and Molecular Medicine
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Conference Abstract| September 01 1973
Clin Sci Mol Med (1973) 45 (3): 9P.
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Demonstrations. Clin Sci Mol Med 1 September 1973; 45 (3): 9P. doi: https://doi.org/10.1042/cs045009P
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Est. $359,556Sold 06/27/2022
Fallon, NV 89406
This Single Family Residence is located at 7925 Beach Rd, Fallon, Nv. The estimated value of this home is currently priced at 211,952. 7925 Beach Rd is within the school district Churchill County School District with nearby schools including Numa Elementary School, Churchill County Middle School, and Churchill County High School.
Public High School
Grades: 9-12Students: 985
Attendance Zone
Public Middle School
Grades: 6-8Students: 704
Attendance Zone
Public Elementary School
Grades: 2-6Students: 531
Attendance Zone
7925 Beach Rd
Fallon, NV 89406


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H. Henry1, N. Marmy Conus2, P. Steenhout2, A. Benguin1, O. Boulat1
1University of Lausanne, 2Nestac Ltd.
This article summarizes the work of H. Henry and associates at the Clinical Chemistry Laboratory, Centre Hospitalier Universiaire Vaudois, University of Lausanne, CH-1011 Lausanne, Switzerland1. Determination of L- and D-lactic acid enantiomers (Figure 1) and their subsequent quantification is of vital importance in infants, as a major excess of D-lactic acid production can lead to metabolic acidosis resulting into significant neurological symptoms if left untreated. Thus, D-lactic acid has the potential to be a clinical marker for the diagnosis of these diseases. Hence it is of great significance for clinical diagnosis to assay lactic acids, especially, D-lactic acid level. There is a need for a reliable and selective method to detect and quantify D-lactic acid. This work demonstrates development of a new and highly sensitive analytical method for a simultaneous determination and quantification of L- and D-lactic acid enantiomers. The method demonstrates the application of Supelco's Astec CHIROBIOTIC® R chiral column in an LC-MS/MS to chirally separate L- and D-lactic acid enantiomers. In addition, the linearity and precision of this method are good. This application is rapid, simple and reproducible for clinical routine detection of L- and D-lactic acid enantiomers.
The L- and D- isomers of lactic acid, both can contribute to metabolic acidosis, but their relative contributions are distinguishing due to their different origins and metabolic pathways. Therefore, it is important to distinguish the isomers of lactic acid in plasma for understanding their relative contributions to metabolic acidosis. However, because of the similar physical and chemical properties of both enantiomers, it is difficult to determine the isomers of lactic acid in biologic samples. Thus, it is necessary to develop a sensitive and reliable method for the separation and quantification of lactic acid enantiomers in urine samples. Currently enzymatic assays withD-lactic acid dehydrogenase are being applied to measure the D-lactic acid in urine. However the enzymatic assays lack sensitivity and specificity in urine controls of newborns, due to low levels of D-lactic acid, that are below the level of quantification by the enzymatic method.
Figure 1. Structure of L- and D- Lactic Acid
The current work has demonstrated a reliable and reproducible analytical method for the simultaneous determination and quantification of L- and D-lactic acid enantiomers in urine by purification and concentration of the organic acids followed by chiral chromatography coupled to tandem MS. This method is rapid, simple and effective for clinical routine detection of L- and D-lactic acid enantiomers. This method deployed the use of Astec CHIROBIOTIC R chiral column, which is available here. With this analytical method, L-lactic acid can be quantified within a range of 2-400 ìm/L and D-lactic acid can be quantified within a range and 0.5-100 µm/L, with accuracy and high precision (Figure 2).
HPLC (Isocratic in an HPLC MS-MS system):
column:Astec CHIROBIOTIC R Chiral Column, 15 cm x 2.1 mm I.D., 5 µm (13019AST)
mobile phase:15% (v/v) 33.3 mM ammonium acetate in H2O and 85% (v/v) acetonitrile
flow rate:0.7 mL/mi
column temp.:4 °C
detector:MS, ESI(-), MRM, m/z 89.1/43.3, 90.1/44.3, 93.1/46.3
Figure 2.LC MS/MS Chromatogram Showing the Chiral Separation of Urinary L- and D-Lactic Acid using an Astec CHIROBIOTIC® R Chiral HPLC Column HPLC (Isocratic in an HPLC MS-MS system): column: Astec CHIROBIOTIC® R Chiral Column, 15 cm x 2.1 mm I.D., 5 µm (Product No. 13019AST); mobile phase: 15% (v/v) 33.3 mM ammonium acetate in H2O and 85% (v/v) acetonitrile; flow rate: 0.7 mL/min; column temp.: 4 °C; detector: MS, ESI(-), MRM, m/z 89.1/43.3, 90.1/44.3, 93.1/46.3
The Astec CHIROBIOTIC® R chiral column is most suitable for enantio-resolution of hydrophilic acids like alpha-hydroxy/halogenated acids and N-blocked amino acids. This phase's unique ionic character and H-bond capability play an important role in the chiral recognition mechanism. Also, we offer a variety of other chiral stationary phases that can be used in above capacity to resolve enantiomers of diverse molecules.


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Rashford, Mbappe & Dembele up for 2017 Golden Boy Award
Kylian Mbappe, Ousmane Dembele, Marcus Rashford and Christian Pulisic have been named among the 25 nominees for the 2017 Golden Boy award.
Last year, Manchester United's Rashford finished runner-up to Renato Sanches, who is on loan at Swansea from Bayern Munich.
Dembele and Pulisic have also been nominated for the prize, which is handed out in October.
The award is handed out annually by Italian newspaper, Tuttosport, to Europe's top footballer under the age of 21. The winner will be decided by a panel of 30 journalists.
2017 Golden Boy nominees:
Aaron Martin (Espanyol), Jean-Kevin Augustin (RB Leipzig), Rodrigo Bentacur (Juventus), Steven Bergwijn (PSV Eindhoven), Dominic Calvert-Lewin (Everton), Federico Chiesa (Fiorentina), Ousmane Dembele (Barcelona), Amadou Diawara (Napoli), Kasper Dolberg (Ajax), Gianluigi Donnarumma (AC Milan), Gabriel Jesus (Manchester City), Joe Gomez (Liverpool), Benjamin Henrichs (Bayer Leverkusen), Borja Mayoral (Real Madrid), Kylian Mbappe (Paris Saint-Germain), Emre Mor (Celta Vigo), Reece Oxford (Borussia Monchengladbach), Christian Pulisic (Borussia Dortmund), Marcus Rashford (Manchester United), Allan Saint-Maximim (Nice), Dominic Solanke (Liverpool), Theo Hernandez (Real Madrid), Youri Tielemans (Monaco), Enes Unal (Villarreal), Kyle Walker-Peters (Tottenham).
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