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iHeartRadio presents Adam Lambert
Civic Theatre, Auckland, New Zealand
August 5, 2015
Reviewed by HAZEL REID
Photos by Steve Dykes
Adam Lambert has amazing vocals and a huge presence, there's no denying that. The American rockstar walked on stage at Auckland's Civic Theatre last night in his signature style – heeled boots and fingerless gloves – to a loud crowd of Kiwi fans.
He hasn't been back on the solo show circuit for awhile, as he most recently toured the world (including NZ late last year) as the frontman for music legends, Queen.
iHeartRadio put on last night's show for the ultimate Adam Lambert fans, or 'Glamberts', as they're also known. It was an hour-filled extravaganza of throwbacks from his first record (For Your Entertainment) through to new tunes off the recently-released The Original High.
Adam put on an amazing performance alongside his four-piece band. He belted out his ballads, including new tunes Underground and After Hours as well as his hit songs What Do You Want From Me and a remix of If I Had You. Ghost Town, my new favourite off his new album, was also on the setlist.
I loved when he explained what There I Said It was about, because relatable tunes are the best: "This one is for all the haters who told you you're doing it wrong." While Another Lonely Night, he said, was about "being addicted to someone... we've all had that one person in our lives." Adam added that the new album was "therapy" for him.
He obviously loves the Kiwis, as he kept asking the technicians to turn on the house lights so he could see "all the beautiful faces". He also asked the crowd how we greet each other. One female fan up the front told him we say "hey bro", to which Adam replied: "Oh, but you ain't a bro, you're a beautiful women with a sense of style." Can you love him any more?!
Adam ended the show with a mix of his tune Trespassing and Queen's classic Another One Bites The Dust. He then went onto purposely and very sassily drop his microphone; what a way to make an exit!
He had the crowd in cheers, claps and screams for the entire concert as he strutted across the stage. I highly recommend you go check him out in January next year.
Adam Lambert's album The Original High is out now and it's just been announced that he's heading back to NZ for a big concert in January 2016! Tickets are available for his Auckland Town Hall show from Ticketmaster next Thursday (13th) at 10am.


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JoAnne Masucci, the co-owner of Ted's Flooring in Albany, says that little has changed in the flooring world: "You want an item that will stand the test of time, and with flooring, paying a little more will get you a real high quality product that will give you beautiful floors for years and years." Masucci says that each customer who enters her store has different taste and different ideas, but here are some of the most common trends she has noticed over the years:
Bamboo. Bamboo has been making appearances in many home decor websites and magazines. It is considered to be one of the more environmentally efficient floors, because bamboo grows rapidly and can be harvested very quickly, meaning fewer need to be planted at a time. "Other than that, you're not really getting something from bamboo that you can't get from a nice red oak," Masucci said. "People who end up buying bamboo floors have had bamboo flooring in their head since before they walk into our store. Most people who are open to any type of wood floor don't settle on bamboo in the end."

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Tour Guide at Albion College
Class of 2024
Hometown: dallas, TX
Major: Psychology
Minor: spanish
I chose to come to Albion college because of the vast amount of equal opportunity here on campus. Furthermore, with this being a smaller campus, there is more professor student relationships available here which allows me to get more help if needed than if I was at a university.
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Being Captain/President of the dance team, I have found that I love being at the dance studio.
My main goal is to graduate and obtain the skills I need for life when I am done with school. When that happens to get a nice job and continue one with life.


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With the free random video chat app, it's attainable to make a reference to the right person on the click of the mouse. The free video calls allow the formation of associations in quick time. Twoo is ideal for everyone from wanting to arrange a first date to the extra seasoned social animal. The central theme of the video chat with strangers app is the flexibility to attach with a large group of customers worldwide. The app hopes to attach people from around the globe in a easy means and supply a platform via which they will communicate and have enjoyable collectively. It is extremely easy to start using Cam Surf, merely visit their website and you're off. It is a random video chat network but it also allows users to rate each other, which makes it a pretty enjoyable place to meet attention-grabbing characters.
TinyChat is of the largest voice and video chat providers on the Internet at present. The company boasts that users produce a combined 5 million minutes of airtime per day. You can attempt the old fashioned technique of going to a bar, or you can log on and participate in one of the many chat rooms that are available on the internet. Their main focus is on making online chatting easy and safe. They have millions of users from all around the world, and are at all times adding new options that make their video calling app better. You don't need to install anything as it's a browser-based site.
You can use Ablo for free, however if you want to access genre or country filters you'll need to purchase in-app foreign money. Just like with the unique Omegle website, on EmeraldChat you can chat by way of textual content solely, if this is what you favor. For $3.89, you'll have the ability to unlock Emerald Gold and get access to style and karma stage filters, and extra. Most rooms don't allow simple friends in, so you'll wish to create an account whether or not you plan on being a room creator or a joiner.
One of the most well-liked sites is called Omegle, the place members converse via video, audio, or just plain textual content. It's a fantastic place to meet random people and just pick up a conversation with a complete stranger. But as is true with most big sites, Omegle has turn out to be overpopulated.
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Save as much as 90% with verified coupons for on a daily basis purchases on your favourite apps. Cancel a subscription / trial at anytime by blocking the positioning or app in your Justuseapp Card. The better chathub.net part is that the website is extremely mobile-friendly. The website performs the finest way on both desktop and cell gadgets.
There is not any assure that your information will ever be exposed by an anonymous chat app, but there may be also clearly no assure that it'll not. If you need your secrets and techniques protected, one of the best coverage should to keep them to your self.
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I think most want to make different people snicker and so they do some outrageous things and put on some fairly clever costumes and disguises. Once you make your choice, simply click the "ZAP" button and you will be linked. If you like the individual you may be related with, you can click on the "Friendship" button to "meet" this particular person again. If you don't like them, click the "Blacklist" button and you'll by no means be linked to that individual again.
You can get began with the website by selecting your gender. There are options to filter who you get to satisfy by choosing the gender and country. CamSurf is another easy stranger chatting website like Omegle. It does not want you to download or install something, either. On the opposite facet, it will be nice to have some further filtering choices while choosing the correspondents. If you are looking for an Omegle alternative as popular as Omegle, you should check out what Camfrog has to supply.
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Around 50 million individuals worldwide use Tinder — so irrespective of where you travel, it's like that another individuals will be swiping, too. Tinder additionally presents a service, Tinder Passport, that lets you change your location in advance of your plans (though you must pay for Tinder Plus or Tinder Gold to entry it).
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Ollie Mattison is a author and a lover of all things video. The face masking option comes very helpful whether you wish to disguise your id or have fun. Allows you to register an account and delete it at any time you want. Make certain to only use websites with reputable safety and security measures. Rajesh Namase is among the prime tech bloggers and one of many first people to show running a blog and digital advertising right into a full-time career.
He has a fantastic ardour for technology, digital advertising, and search engine optimization. It is feasible to select the region and language of the goal consumer groups. On offer is among the quickest potential messaging choices out there for the free consumer. It is possible to have the app installed on each the cell phone and desktop and synchronize the two. There is the facility to segregate out the nearest individuals which make bodily social interactions easy to do. Just like other well-known social networking platforms, Chatous is one of the finest talk with strangers apps with comparable features and choices. This app might help you get linked to completely different individuals very quickly without any issue.
Live Video Call – Random Video Chat Livetalk is a free app for Android, that makes a part of the class 'Social & Communication'. First, go to the "My Account" part, then hit "delete my account" option. Only credit cards and Stripe can be used for the payment, there is not an choice of PayPal. You can cancel the plan anytime they usually do not retailer your cost data. You will get an in-chat verified badge in your profile that ensures the person trust.
It's additionally attainable that investigators can trace deleted WhatsApp messages—except they have been encrypted. If you utilize your Android for file storage, those recordsdata would possibly nonetheless be hanging round in storage, too.
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Women and men's separate on the ground realities in the agricultural and fisheries sectors must be the cornerstone on which policies are developed
Launch of two key toolkits developed by UN Women MCO Caribbean under the UN Trust Fund for Human Security (UNTFHS) Joint Programme for parliamentarians on the ParlGender Tools E-platform which focus on integrating gender equality and human security in Agricultural Policy and Structural Adjustment Programmes.
This inaugural issue of the Caribbean Regional Spotlight Initiative Newsletter highlights foundational elements established so far to ensure the success of the regional programme.
UN Women Executive Director kicks off the UNiTE campaign to end gender-based violence during the UN Trust Fund to end Violence Against Women grantee Convention
At the first ever grantee Convention of the UN Trust Fund to End Violence against Women (UN Trust Fund), UN Women today kicked off its annual activities for the UN Secretary-General's UNiTE by 2030 to end Violence against Women campaign in support of the 16 days of Activism against Gender-Based Violence.
Bridgetown, Barbados - While Dominica, Grenada and Trinidad and Tobago are among the countries in the Caribbean and Americas region where women ministers are nearing or exceeding the gender parity position of 30 per cent of representatives, the number of women in executive government and in parliament worldwide has stagnated.


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D 21/22 A Ranamahal Ghat, Bangali Tola Lane, Dashaswamedh Ghat, Varanasi, Varanasi 221001+91 542 245 4873
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Paradise Inn Guest House location: D 21/22 A Ranamahal Ghat, Bangali Tola Lane, Dashaswamedh Ghat, Varanasi, Varanasi 221001
3.7 km
Check in anytime after 12:00, check out anytime before 12:00
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The Americans Recap: Season 4, Episode 7, "Travel Agents"
The episode is, in one sense, a portrait of a woman on the verge of a nervous breakdown.
Tonight's episode of The Americans comes to a head as Elizabeth (Keri Russell) knocks the wind out of Martha (Alison Wright), the latter's insistent protests supplanted by staccato gasps. In the show's arc this season, "Travel Agents" performs much the same function: A sharp exhalation, a moment of release, paves the way for a more restrained, if no less formidable, reckoning. One half of the episode is made up of searches, stakeouts, and wiretaps; the other, of questions, confessions, and tangled sympathies. It is, in short, a cleverly constructed hybrid, resolving the tension of the previous three episodes only to unleash a torrent of emotion. It's as if the body blow Elizabeth delivers is the last crack in the dam, and the characters are left waiting downriver for the terrible flood to arrive.
In this vein, "Travel Agents" demonstrates an intense interest in consequences still to come, an entire hour of foreshadowing. The camera lingers on Elizabeth's stony expression, for example, as Gabriel (Frank Langella) remarks on the extreme measures that might be necessary to bring Martha back into the fold, or on Frank Gaad (Richard Thomas) in the F.B.I.'s conference room, eyes closed against the fact that there's no innocent explanation for his secretary's behavior.
Even the episode's asides suggest conspiracies within conspiracies, stacked like Russian nesting dolls: the KGB telephone operator's interrupted description of the "weird feeling" she had upon her accelerated deployment to the United States; the pointed insert of the red folder that Tatiana (Vera Cherny) closes when Oleg (Costa Ronin) visits her office. Something's amiss here, the gears of the season's second half grinding into action as a woman on the lam distracts those on both sides of the Cold War divide.
There is, after all, something about Martha, in particular her quiet strength. Over the course of nearly 50 episodes, she's proven her mettle time and again, yet the KGB and the F.B.I. alike continue to underestimate her—the recesses of the human heart being the one source of intelligence that no amount of training or technological advancement can prepare one to penetrate, at least not with perfect confidence. As Gaad wonders aloud to Stan (Noah Emmerich) at one point: "Was she that unhappy?"
"Travel Agents" is, in one sense, a portrait of a woman on the verge of a nervous breakdown: The camera circles Martha on a city street as she spins in the opposite direction—a dizzying, disorienting replication of her mounting panic. But the episode also confirms that giving Martha so little credit was an egregious error in judgment: The notion that the shy office functionary should be capable of destroying careers, directing threats, and resisting control seems not to have crossed anyone's mind before this.
That Martha isn't in fact unfathomable becomes clear through the episode's masterly repetition of a single image, the arched span of the viaduct high above Rock Creek Park. Philip recalls Martha's many visits there during her mother's illness; Stan spies it in a photograph from the F.B.I.'s burgeoning file; it rises in the distance as she bids farewell to her parents, or as Stan and Agent Aderholt (Brandon J. Dirden) drive alongside the fast-moving river. Investigators overturn her apartment in search of clues, melting ice with a hair dryer and unraveling tampons one by one, but Martha's refuge is no secret—it's written in her memory, inscribed in her past, except that those closest to her never deigned to listen. It's telling that even Philip and Stan, Martha's most perceptive pursuers, only discover her whereabouts after her telephone calls tip them off: In "Travel Agents," culminating with the warning to Elizabeth that she'll scream, Martha demands to be heard.
The onrush of breath that accompanies Elizabeth's gut-punch thus signals a closing off of possibilities, a silencing, and the episode's latter stages retreat into a mournful hush. Philip, confronted with Elizabeth's suggestion that he'd prefer to join Martha in the Soviet Union, finally shows his cards, and a future with Martha isn't in them. The answer to Gaad's question turns out to be yes. The abyss Martha stares into after Philip reveals that he won't be coming with her is as profound as the ravine under the viaduct: cold and rocky, frothing with life's cruel currents.
Even for The Americans, the moment is indescribably bleak, and whatever happens to Martha after "Travel Agents," it seems that the water behind the dam will carry her away regardless. At the conclusion of a four-episode arc in which Wright's performance, always extraordinary, emerged as the finest on television, the desolation she finds in Martha's voice as her fate becomes clear to her sounds such depths of grief it also left me gasping. "I'll be alone," she says to Philip, dredging up the most painful memory of all. "Just the way it was before I met you."
For more recaps of The Americans, click here.
This article was originally published on The House Next Door.
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Property Tax Lawyers in Saugus
The government of Saugus, Massachusetts requires most people who own real property to pay taxes on its value. "Real property" refers to land and buildings, as well as anything else which is permanently adhered to a piece of land, including trees, oil, groundwater, minerals, and the like.
Saugus, Massachusetts determines property taxes simply by taking a percentage of the property's value. Normally, they are paid on a yearly or monthly basis.
In general, the federal government does not impose any property tax. Usually, property tax is imposed by state, county, and municipal governments.
How Property Tax is Calculated in Saugus, Massachusetts
Saugus, Massachusetts calculates its property taxes by requiring property owners to pay a set percentage of the appraised value. While the property tax rate varies greatly across different parts of the country, they fall into the 1-5% range.
To levy this tax, Saugus, Massachusetts tax authorities must first figure out how much a house or piece of land is worth.
In some ways, value is a subjective thing. For example, the home in which you grew up is probably worth far more to you than its market value. To get around this, the government uses nothing but objective factors in determining how much a piece of real property is worth.
Thus, the people in charge of appraising the value of property in Saugus, Massachusetts have to consider only objective, factual criteria when calculating the value of a piece of land. These criteria include the state of the real estate market, the zoning of the land (which determines how it can be used), and any improvements that have been made to the land, among other things.
How A Saugus, Massachusetts Property Tax Attorney Can Help.
The system of levying property taxes in Saugus, Massachusetts can get fairly difficult. Disputes about property taxes, between the taxpayer and the tax authorities, can come up in many different ways. A taxpayer may believe that an error was made in calculating their property's taxable value, resulting in bigger tax bill. Furthermore, the state or city government might allege that you have failed to pay your property taxes, while you believe that you have.
If you run into any issue with your Saugus, Massachusetts property taxes, failing to handle it properly can result in anything from unnecessary inconvenience to massive fines and tax penalties. However, with the help of a Saugus, Massachusetts tax attorney, your chances of running into a property tax problem can be minimized.


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This piece is one among 10 winners of our 2022 Profile Contest. Yow will discover extra right here. Haedam Lee, 14, and Yeonji Joo, 13, the authors, go to Branksome Corridor Asia in Seogwipo Metropolis, South Korea.
Actual-Life Aquawomen: The Haenyeo
by Haedam Lee and Yeonji Joo
A cluster of "orange flowers" floats alongside the broad Jeju ocean, dancing with the waves. All of a sudden, "Hwui! Pah …" and a haenyeo comes out onto the floor of the chilly winter sea. She stuffs a small abalone into the online hooked up to the floating orange buoy and prepares to dive once more. Within the midst of a puff from the haenyeo, a whalelike whistle is audible once more. That is sumbisori: a sound made within the technique of inhaling with out the assistance of any expertise by feminine divers in Jeju, a Korean province.
"Hwui! Hah …" one other catches her breath after a deep dive because the 55-year-old Haenyeo, Lee Ji-hye, takes her flip.
A beginner within the haenyeo society, Ms. Lee moved to Jeju from Seoul six years in the past. Whereas working as a diver and harvesting sea creatures for numerous hours, Lee discovered herself uncovered to the severity of air pollution.
"What was the cleanest sea I've ever been to is now a area of plastic," mentioned Ms. Lee.
At first, she was fascinated by the character of Jeju, because the island was recognized for its pristine ecosystem. In line with Ms. Lee, nonetheless, that is not the case. In her month-to-month dives, she encounters waste floating across the ocean.
"We generally dive within the ocean simply to gather trash," she mentioned.
As a result of haenyeos depend on nature and dive with out the help of expertise, local weather change and air pollution pose an imminent menace, as their lives and livelihoods are in danger.
The next are excerpts from conversations with Ms. Lee, translated from Korean and edited for readability.
What occurs in a day within the lifetime of a haenyeo?
First, we meet on the shore and put together our fits, taewaks [the orange floats that hold the catch] and different tools. Then, we verify the climate to verify it's protected for us to dive. As soon as confirmed, we experience a small boat onto the ocean and dive in! We work for 5 hours or extra, diving out and in of the water to scavenge for sea creatures. Then, we come out, hop on the boat again to the island and clear our harvests in addition to ourselves. Though our work is just not lengthy, it's positively tiring.
What was your most troublesome and gratifying second whereas being a haenyeo?
A lot of the actions we do as haenyeos are dangerous; nonetheless, the arduous bodily labor is probably the most demanding. We dive greater than 200 instances a day, which implies a excessive degree of stamina and respiration methods are crucial. As most haenyeos are previous, it will get tougher to maintain up with what's required for work. Then again, probably the most gratifying a part of being a haenyeo is the satisfying feeling when diving into the water with out fascinated about something. Though being a haenyeo is difficult, I really like my job as a result of it's really what I need to do.
Had been there any accidents that you just skilled whereas working?
The danger of being captured in ocean trash like previous nets is a giant downside. Massive nets are nearly invisible after we get within the water. As we solely depend upon our breath when diving, it's arduous to assume logically if we out of the blue get caught and panic. Not solely the nets, however plastic air pollution can also be a problem. Many instances we might discover plastic hanging on urchins. To resolve this difficulty, generally we dive simply to gather plastic from the ocean. Though this won't eradicate the issue, we try and alleviate ocean waste as our work is immediately linked to the sustainability of nature. If nature can't be protected, we have now no work to do.
Have you ever seen or felt the results of local weather change or rising temperatures whereas working?
We typically work early mornings when the ocean is colder, about 15 levels Celsius (59 levels Fahrenheit). Nevertheless, temperatures just lately stay at 17 levels Celsius which permits sharks to inhabit the hotter waters. This poses a menace whereas we work in shallow waters. Additionally, throughout the summer season, I've witnessed underwater crops like algae melting resulting from excessive warmth. Algae is just not solely our supply of earnings but in addition meals for different marine life. To cease the cycle of nature and our livelihood being destroyed, we'd like the temperature to drop once more.


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Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder that causes excess lipid accumulation in the liver and is the leading cause of end-stage liver disease. Liriope platyphylla is a medicinal herb that has long been used to treat cough, obesity, and diabetes. However, the effect of Liriope platyphylla on NAFLD has not been studied. The aim of this study was to investigate the effect of Liriope platyphylla root ethanolic extract (LPE) on hepatic lipid accumulation in high-fat diet (HFD)-induced obese mice. Six-week-old C57BL/6 male mice were fed a HFD for 8 weeks and then treated with LPE (100 or 250 mg/kg/day) by oral gavage for another 8 weeks. Body weight gain and liver weight were significantly lower in the 250 mg/kg LPE-treated HFD group than in the vehicle-treated HFD group. Histological analysis of liver sections demonstrated that LPE treatment reduced lipid accumulation compared to the vehicle treatment. The serum total cholesterol, AST, and ALT levels significantly decreased in the LPE-treated HFD group compared to those in the vehicle-treated HFD group. The LPE significantly decreases the protein expression levels of SREBP1, ACC, p-ACC, FAS, and SCD1, which are involved in lipogenesis, and PPARγ, CD36/FAT, and FATP5, which are involved in fatty acid uptake, both in vivo and in vitro. Thus, LPE may attenuate HFD-induced NAFLD by decreasing lipid accumulation by inhibiting lipogenesis and fatty acid uptake.
AssuntosDieta Hiperlipídica , Etanol/química , Lipídeos/sangue , Lipogênese , Liriope (Planta)/química , Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Raízes de Plantas/química , Animais , Ácidos Graxos/metabolismo , Regulação da Expressão Gênica , Células Hep G2 , Humanos , Lipogênese/genética , Fígado/metabolismo , Fígado/patologia , Masculino , Camundongos Endogâmicos C57BL , Camundongos Obesos , Extratos Vegetais/farmacologia , Triglicerídeos/sangue , Aumento de Peso
Saponin monomer 13 of the dwarf lilyturf tuber (DT-13) is a steroidal saponin component isolated from the tuber of Liriope muscari (Decne.) Bailey that exhibits multiple pharmacological activities. We used a liquid chromatography-tandem mass spectrometry method and MetaboLynx XS software to investigate the metabolites of DT-13 in vivo and obtained potential metabolites and changes in functional groups during the formation of metabolites from the substrate. The main metabolites obtained had the ruscogenin (RUS) backbone structure. We also report a competitive fluorescence-linked immunosorbent assay (FLISA) based on monoclonal antibodies (MABS) conjugated with quantum dots (QDs) for rapid and sensitive quantitative analysis of DT-13 and its metabolite levels in biological samples. Using this method, the DT-13 levels detected in rat urine and feces displayed a good linear relationship within the corresponding linear ranges. The DT-13 recovery rate ranged from 85.28 to 101.40%, with a relative standard deviation of 2.96-9.26%. The method was successfully applied to study the distribution of DT-13 excretion in rats after oral administration. DT-13 was primarily excreted in the urine after metabolism. This study provides a new tool for pharmacokinetic studies of DT-13 and other active substances for which the analysis efficacy does not match the bioavailability or that are difficult to study using isotope labeling.
AssuntosImunoadsorventes , Liriope (Planta) , Pontos Quânticos , Saponinas , Animais , Fluorescência , Ratos , Saponinas/análise
Although significant progress has been made in the treatment of lung cancer, it remains the leading cause of cancerassociated mortality. Liriopesides B (LPB) is a natural product isolated from the tuber of Liriope platyphylla, whose effective substances have exhibited antitumor activity in several types of cancer. However, the functions of LPB in nonsmall cell lung cancer (NSCLC) require further investigation. Therefore, the present study aimed to investigate whether LPB influences the pathogenic effects of NSCLC. In the present study, it was demonstrated that LPB reduced proliferation, and induced apoptosis and cell cycle arrest in nonsmall cell lung cancer cells. CCK8 and colony formation assays demonstrated that LPB decreased cell viability and proliferation of H460 and H1975 cells in a dosedependent manner. Flow cytometry revealed that LPB significantly induced apoptosis of NSCLC cells, along with changes in the expression of apoptosisassociated proteins, including an increase in Bax, caspase3, and caspase8 expression, and a decrease in Bcl2 and Bclxl expression. LPB inhibited the progression of the cell cycle from the G1 to the S phase. Furthermore, autophagy was increased in cells treated with LPB. Finally, the expression of programmed deathligand 1 was significantly decreased by LPB. In conclusion, the results of the present study highlight a potential novel strategy for the clinical treatment of NSCLC.
AssuntosAntineoplásicos Fitogênicos/farmacologia , Apoptose/efeitos dos fármacos , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Pontos de Checagem do Ciclo Celular/efeitos dos fármacos , Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia , Neoplasias Pulmonares/tratamento farmacológico , Compostos de Espiro/farmacologia , Carcinoma Pulmonar de Células não Pequenas/metabolismo , Carcinoma Pulmonar de Células não Pequenas/patologia , Linhagem Celular Tumoral , Compostos Heterocíclicos de 4 ou mais Anéis/química , Humanos , Liriope (Planta)/química , Neoplasias Pulmonares/metabolismo , Neoplasias Pulmonares/patologia , Compostos de Espiro/química
Acute myeloid leukemia (AML) is a malignant disease originating from hematopoietic stem cells (HSC). Chemotherapy and/or HSC transplantation is unsatisfactory due to serious side effects, multidrug resistance, and high relapse rate. Thus, alternative strategies are urgently needed to develop more effective therapies. Liriope muscari baily saponins C (DT-13) is a novel compound isolated from Liriope muscari (Decne.) Baily, and exhibited a potent cytotoxicity against several solid tumors. However, the anti-AML activity of DT-13 and the potential mechanisms are still unknown. This study is the first to demonstrate that DT-13 had preferential cytotoxicity against AML cells, and remarkably inhibited proliferation and colony forming ability. Moreover, DT-13 induced the death receptor pathway-dependent apoptosis of HL-60 and Kasumi-1 cells by up-regulating Fas, FasL, DR5 and TRAIL as well as promoted the cleavage of caspase 8, caspase 3 and PARP. Meanwhile, DT-13 induced the differentiation with morphological change related to myeloid differentiation, elevated NBT and α-NAE positive cell rates, differentiation markers CD11b and CD14 as well as level of transcription factors C/EBPα and C/EBPß. RNA-sequencing analysis revealed that KLF2 may be one of the potential targets regulated by DT-13. Further studies indicated that KLF2 played a critical role in DT-13-induced apoptosis and differentiation. Moreover, activation of AMPK-FOXO was proved to be the upstream of KLF2 pathway that contributed to the induction of apoptosis and differentiation by DT-13. Additionally, restoration of KLF2 by DT-13 was highly correlated with the AMPK-related histone acetylation mechanisms. Finally, DT-13 exhibited an obvious anti-AML effect in NOD/SCID mice with the engraftment of HL-60 cells. Our study suggests that DT-13 may serve as a novel agent for AML by AMPL-KLF2-mediated apoptosis and differentiation.
AssuntosProteínas Quinases Ativadas por AMP/efeitos dos fármacos , Antineoplásicos Fitogênicos/farmacologia , Apoptose/efeitos dos fármacos , Diferenciação Celular/efeitos dos fármacos , Fatores de Transcrição Kruppel-Like/efeitos dos fármacos , Leucemia Mieloide Aguda/patologia , Saponinas/farmacologia , Transdução de Sinais/efeitos dos fármacos , Animais , Linhagem Celular Tumoral , Humanos , Liriope (Planta)/química , Camundongos , Camundongos Endogâmicos NOD , Camundongos SCID , Ensaio Tumoral de Célula-Tronco
BACKGROUND: Liriope muscari (Decne.) L.H. Bailey is a valuable horticultural and medicinal plant that grows under a range of light intensities, from high to low, in the understories of shrubs. To understand how this species adapts to these various environments, we selected two groups of lilyturf growing under poplar trees at two different spacings. Each group was divided into three types, open field, forest edge and shaded forest with high, medium and low irradiance levels, respectively, and then we examined their photosynthetic characteristics, physiology and biomasses. RESULTS: Light saturation point, light compensation point and in situ net photosynthetic rate (PN) were highest in lilyturf growing under high light. In contrast, lilyturf growing under low light had a higher apparent quantum yield and Chl a and b contents, indicating that they adapted to low light. Although the leaves of lilyturf growing under low light were small, their root tubers were heavier. CONCLUSIONS: The research demonstrates the eco-physiological basis of lilyturf's shade adaptation mechanism as indicated by photosynthetic activity, chlorophyll fluorescence, Chl a, Chl b and Car contents when grown under different irradiances. We believe that lilyturf is a shade-tolerant plant suitable for planting in undergrowth, but attention should be paid to the canopy density of the forest when interplanting. The findings presented here advance our understanding of the photosynthetic characteristics of understory plants and may assist in the optimization of irradiances in the future.
AssuntosAsparagaceae , Liriope (Planta) , Florestas , Fotossíntese , Folhas de Planta
BACKGROUND: Tumor metastasis is a terrifying characteristic of cancer. Numerous studies have been conducted to overcome metastasis by targeting tumor microenvironment (TME). However, due to complexity of tumor microenvironment, it remained difficult for accurate targeting. Dwarf-lillytruf tuber monomer-13 (DT-13) possess good potential against TME. OBJECTIVE: As TME is supportive for tumor metastasis, alternatively it is a challenging for therapeutic intervention. In our present study, we explored molecular mechanism through which TME induced cell migration and how DT-13 interferes in this mechanism. METHODS: We used a novel model of co-culture system which is eventually developed in our lab. Tumor cells were co-cultured with hypoxia induced cancer-associated fibroblasts (CAF) or with chemically induced cancer-associated adipocytes (CAA). The effect of hypoxia in conditioned medium for CAF was assessed through expression of α-SMA and HIF by western blotting while oil red staining was done to assess the successful chemical induction for adipocytes (CAA), the effect of TME through conditioned medium on cell migration was analyzed by trans-well cell migration, and cell motility (wound healing) analyses. The expression changes in cellular proteins were assessed through western blotting and immunofluorescent studies. RESULTS AND CONCLUSION: Our results showed that tumor microenvironment has a direct role in promoting breast cancer cell migration by stromal cells; moreover, we found that DT-13 restricts this TME regulated cell migration via targeting stromal cells in vitro. Additionally we also found that DT-13 targets NMII-A for its effect on breast cancer cell migration for the regulation of stromal cells in TME.
AssuntosNeoplasias da Mama/tratamento farmacológico , Cadeias Pesadas de Miosina/metabolismo , Saponinas/farmacologia , Animais , Neoplasias da Mama/imunologia , Neoplasias da Mama/metabolismo , Neoplasias da Mama/patologia , Fibroblastos Associados a Câncer/efeitos dos fármacos , Fibroblastos Associados a Câncer/metabolismo , Fibroblastos Associados a Câncer/patologia , Linhagem Celular Tumoral , Movimento Celular/imunologia , Feminino , Humanos , Liriope (Planta)/química , Camundongos , Cadeias Pesadas de Miosina/genética , Transdução de Sinais , Microambiente Tumoral/efeitos dos fármacos , Microambiente Tumoral/imunologia
BACKGROUND: Gastroesophageal reflux disease (GERD) is a major cause of chronic cough. GERD-induced chronic cough is difficult to diagnose because some patients do not complain of any gastrointestinal (GI) reflux symptoms. Although chronic cough due to GERD is highly prevalent, no effective treatment is currently available, especially for GERD-related cough without GI symptoms. Because the herbal medicines Ojeok-san and Saengmaek-san can effectively treat GERD and cough, we aim to evaluate the efficacy and safety of a combination of these components for relieving chronic cough due to GERD. METHODS/DESIGN: This is a study protocol of a randomized, double-blind, placebo-controlled, single-center pilot trial. After a 1-week run-in period, a total of 30 patients with GERD-induced chronic cough will be randomly allocated to an intervention group (n = 15) or a placebo group (n = 15). Participants will receive 5.76 g of Ojeok-san plus Saengmaek-san or a placebo three times per day for 6 weeks. The primary outcome measures, which are the frequency and severity of cough, will be recorded using a cough diary. The secondary outcome measures will include a cough visual analogue scale, the Leicester Cough Questionnaire (Korean version), the Gastrointestinal Symptom Rating Scale, the Hull Airway Reflux (hypersensitivity) Questionnaire, the Pattern Identification for Chronic Cough Questionnaire, the Pattern Identification for Gastroesophageal Reflux Disease, and safety testing. Adverse events will also be reported. DISCUSSION: This will be the first clinical trial to explore the use of herbal medicines for GERD-related chronic cough, including patients without GI reflux symptoms. This study will provide useful evidence regarding the efficacy and safety of Ojeok-san plus Saengmaek-san treatment. In addition, this trial will offer a scientific basis for the combination of herbal medicines. This study will also provide important data for conducting a larger-scale clinical trial on GERD-induced chronic cough. TRIAL REGISTRATION: This trial has been registered with Clinical Research Information Service (CRIS) of South Korea (http://cris.nih.go.kr; registration number KCT0003115). Registered August 28, 2018.
AssuntosTosse/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Preparações de Plantas/uso terapêutico , Doença Crônica , Tosse/etiologia , Método Duplo-Cego , Refluxo Gastroesofágico/complicações , Refluxo Gastroesofágico/tratamento farmacológico , Humanos , Liriope (Planta) , Panax , Projetos Piloto , República da Coreia , Schisandra
The tuberous roots of Liriope platyphylla (Liriopis Tuber; LT) is traditionally used in Korean Medicine for treating colds, cough, and sputum production. In this study, we investigated the effect of spicatoside A isolated from LT methanol extract on ovalbumin (OVA)-sensitized/challenged asthmatic mice. For induction of allergic asthma, BALB/c mice were sensitized with OVA by an intraperitoneal injection at three times a week, and then challenged into the nasal cavities using a nebulizer. Spicatoside A at dose of 1mg/kg body weight was treated in mice with an oral administration once daily for a week during OVA challenge. The concentrations of OVA-specific IgE, IL-4, IL-5 and IL-13 were measured in the sera or bronchoalveolar lavage fluids (BALF) of mice by enzyme-linked immunosorbent assay (ELISA). The numbers of total cells, macrophages, lymphocytes, neutrophils and eosinophils were counted in BALFs using Diff-Quik staining, and histopathological changes of lung tissues were observed by hematoxylin and eosin (H&E), Periodic acid Schiff (PAS) and Masson's trichrome staining. The purity of spicatoside A was 98.1% with a white powder (yield: 465.6mg). The treatment of spicatoside A in asthmatic mice significantly decreased the production of allergic mediator, OVA-specific IgE and Th2 cytokines, IL-4, IL-5 and IL-13 in sera and BALF. The numbers of inflammatory cells such as macrophages, lymphocytes, neutrophils and eosinophils in BALF of asthmatic mice were significantly reduced by the treatment of spicatoside A. Furthermore, the treatment of spicatoside A in asthmatic mice inhibited the structural damages of lung tissues with thickened bronchiolar epithelium and infiltration of inflammatory cells, the accumulation of mucus by the goblet cells hyperplasia and collagen in the bronchioles. These results suggest that spicatoside A of LT has a preventive effect on allergic asthma through the inhibition of lung inflammation and allergic response.
AssuntosAsma/induzido quimicamente , Liriope (Planta)/química , Ovalbumina/farmacologia , Saponinas/farmacologia , Animais , Asma/metabolismo , Líquido da Lavagem Broncoalveolar , Citocinas/metabolismo , Modelos Animais de Doenças , Imunoglobulina E/metabolismo , Inflamação/metabolismo , Pulmão/efeitos dos fármacos , Pulmão/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos BALB C
The hydrogen peroxide generation system was used to analyze the scavenging activity of hydrogen peroxide by Liropes Radix from different origins by HPLC-UV-CL. The UV-CL fingerprints of Liropes Radix from different origins were evaluated,and the HPLC-UV and LC-CL fingerprints were systematically analyzed and evaluated. The results showed that the ether fractions of Liriope spicata var. prolifera and L. muscari had good scavenging activity of hydrogen peroxide,and the total activity of different origins varied greatly,while the similar samples had similar activities. The total antioxidant activity of L. muscari is higher than that of L. spicata var.prolifera. The similarity analysis of the two fingerprints was carried out by two different analytical methods. The chemical fingerprints and the active fingerprints have different characteristics. The contribution of each fingerprint to the total peak area and total activity is also different. There are significant differences between the two different fingerprint clustering results.
AssuntosMedicamentos de Ervas Chinesas , Sequestradores de Radicais Livres/química , Peróxido de Hidrogênio/isolamento & purificação , Liriope (Planta)/química , Extratos Vegetais/química , Cromatografia Líquida de Alta Pressão , Compostos Fitoquímicos/química , Raízes de Plantas/química
Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans worldwide. Although hepatitis E is self-limiting without chronic infection development, HEV infection often leads to severe liver diseases causing high mortality in pregnant women in addition to chronic hepatitis and cirrhosis in immunosuppressed patients. In this study, we investigated the effect of a Liriope platyphylla ethanol extract (LPE) on HEV replication. Interestingly, LPE suppressed replication of the genotype 3 HEV replicon. Sequential solvent fractionation revealed that the ethyl acetate (EA) fraction of LPE exerts the most potent inhibitory effects. With the aid of activity-guided fractionation and multi-step column chromatography, spicatoside A was subsequently isolated in the EA fraction of LPE and specifically shown to exert inhibitory effects on replication of the genotype 3 HEV replicon. In addition, spicatoside A interfered with replication of the HEV genotype 3 strain 47832c and expression of HEV ORF2 capsid proteins. Our findings clearly support the potential utility of spicatoside A as an effective anti-HEV agent.
AssuntosEtanol/química , Vírus da Hepatite E/efeitos dos fármacos , Liriope (Planta)/química , Extratos Vegetais/química , Saponinas/química , Saponinas/farmacologia , Células A549 , Animais , Antivirais/química , Antivirais/farmacologia , Linhagem Celular Tumoral , Genótipo , Vírus da Hepatite E/patogenicidade , Humanos , Extratos Vegetais/farmacologia , Replicação Viral/efeitos dos fármacos
Constipation is an acute or chronic illness attributed to various causes, ranging from lifestyle habits to side effects of a disease. To improve the laxative effects of some traditional medicines, herbal mixtures of Liriope platyphylla, Glycyrrhiza uralensis, and Cinnamomum cassia (LGC) were evaluated for their mechanism of action and therapeutic effects in loperamide (Lop)-induced constipated Sprague Dawley rats by examining alterations in excretion parameters, histological structure, mucin secretion, and related protein levels. Food intake and water consumption were constant for all animals. We observed that the Lop+LGC-treated group had significantly greater excretion of stool and urine than was observed in the Lop+Vehicle-treated group. Administration of LGC in the constipation model restored the intestinal transit ratio to normal levels, and increased the number of goblet cells, mucosal layer, and muscle thickness. Mucin secretion was greater in the Lop+LGC-treated group than in the Lop+Vehicle-treated group, and the expression of MUC2 and AQP8 genes were also increased. In addition, reverse transcription polymerase chain reaction and Western blot revealed an increase in the muscarinic acetylcholine receptors (mAChRs) in the Lop+LGC-treated group compared to the Lop+Vehicle-treated group. Furthermore, compared with the Lop+Vehicle-treated group, treatment with LGC reduced the phosphorylation of PKC and PI3K, and expression of Gα protein, but increased levels of IP3. Our results suggest that the traditional herbal mixture of LGC induces a potent laxative effect in Lop-induced constipation through mucosal tissue changes and mucin production. We also demonstrated that the laxative effect of LGC is closely related to the expression of mAChR and its downstream signals, suggesting the possibility of developing a constipation-laxative agent using LGC.
AssuntosCinnamomum aromaticum/química , Constipação Intestinal/tratamento farmacológico , Glycyrrhiza uralensis/química , Laxantes/administração & dosagem , Liriope (Planta)/química , Extratos Vegetais/administração & dosagem , Animais , Aquaporinas/genética , Aquaporinas/metabolismo , Constipação Intestinal/induzido quimicamente , Constipação Intestinal/genética , Constipação Intestinal/metabolismo , Sinergismo Farmacológico , Loperamida/efeitos adversos , Masculino , Mucina-2/genética , Mucina-2/metabolismo , Ratos , Ratos Sprague-Dawley
BACKGROUND: Emerging hallmark of cancer is reprogrammed cellular metabolism, increased glycolytic metabolism is physiological characteristic of human malignant neoplasms. Saponin monomer 13 of the dwarf lilyturf tuber (DT-13) is the main steroidal saponin from Liriopes Radix, which has been reported to exert anti-inflammation and anti-tumor activities but low toxicity to normal tissue. However, the effect of DT-13 on metabolism process is still unclear. PURPOSE: This study aims to characterize the role of DT-13 in glucose metabolism in colorectal cancer cells, and investigate whether the metabolism process is involved in the anti-cancer response of DT-13. METHODS: Colony formation assay was employed to determine anti-proliferative effect induced by DT-13 at 2.5, 5, 10 µM. Apoptosis and cell cycle arrest were detected by Annexin V/PI staining and PI staining, respectively. Genetic inhibition of glycolytic metabolism was carried out by knockdown of GLUT1. Orthotopic implantation mouse model of colorectal cancer was used to assess in vivo antitumor effect of DT-13 (0.625, 1.25, 2.5 mg/kg). The chemoprevention effect of DT-13 (10mg/kg) was evaluated by using C57BL/6J APCmin mice model. Glycolytic-related key enzymes and AMPK pathway were detected by using quantitative real-time PCR, western blotting, and immunohistochemical staining. RESULTS: Our results showed that cell proliferation was significantly inhibited by DT-13 in a dose-dependent manner. DT-13 inhibited glucose uptake, ATP generation, and reduced lactate production. Furthermore, DT-13 remarkably inhibited GLUT1 expression in both mRNA and protein levels. Knocking down of GLUT1 led to reduced inhibition of glucose uptake after DT-13 treatment. Moreover, deletion of GLUT1 decreased inhibitory ratio of DT-13 on cancer growth. Orthotopic implantation mouse model of colorectal cancer further confirmed that DT-13 inhibited colorectal cancer growth via blocking GLUT1 in vivo. In addition, C57BL/6J APCmin mice model revealed that DT-13 dramatically reduced the total number of spontaneous adenomas in intestinal, which further confirmed the anti-tumor activity of DT-13 in colorectal cancer. Furthermore, the mechanistically investigation showed DT-13 activated AMPK and inhibited m-TOR to block cancer growth in vitro. CONCLUSION: DT-13 is a potent anticancer agent for colorectal cancer.
AssuntosAntineoplásicos Fitogênicos/farmacologia , Neoplasias Colorretais/tratamento farmacológico , Saponinas/farmacologia , Serina-Treonina Quinases TOR/metabolismo , Proteínas Quinases Ativadas por AMP/metabolismo , Animais , Apoptose/efeitos dos fármacos , Pontos de Checagem do Ciclo Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/patologia , Feminino , Transportador de Glucose Tipo 1/antagonistas & inibidores , Transportador de Glucose Tipo 1/genética , Transportador de Glucose Tipo 1/metabolismo , Glicólise , Humanos , Liriope (Planta)/química , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Transdução de Sinais/efeitos dos fármacos , Ensaios Antitumorais Modelo de Xenoenxerto
Red Liriope platyphylla extract (EtRLP) has been used as an oriental medicine for treatment of several chronic conditions, such as neurodegenerative disorders, diabetes, and obesity. To investigate the laxative activity of EtRLP, the levels of key constipation markers and their molecular regulators were examined following administration of EtRLP in constipation Sprague Dawley (SD) rats treated with loperamide (Lop). Compared with the Lop+Vehicletreated group, the excretion levels of urine and stool were significantly enhanced in the Lop+EtRLPtreated group, even though feeding levels were kept constant. There was a significant improvement in histological structure, cytological ultrastructure and mucin secretion in transverse colon sections from the Lop+EtRLPtreated group, compared with the Lop+Vehicletreated group. The Lop+EtRLPtreated group exhibited a rapid recovery of the muscarinic acetylcholine receptor (mAChR) signaling pathway and of the endoplasmic reticulum (ER) stress response, compared with Lop+Vehicletreated group. Spicatoside A, one of the key components detected in EtRLP, recovered the levels of inositol triphosphate (IP3) and Gα in primary rat intestinal smooth muscle cells (pRISMCs). Taken together, the present results indicated that spicatoside Acontaining EtRLP had therapeutic effects against Lopinduced constipation in SD rats via improvement of the mAChR downstream signaling pathway and the ER stress response.
AssuntosConstipação Intestinal/tratamento farmacológico , Constipação Intestinal/patologia , Estresse do Retículo Endoplasmático , Laxantes/uso terapêutico , Liriope (Planta)/química , Receptores Muscarínicos/metabolismo , Saponinas/uso terapêutico , Transdução de Sinais , Animais , Colo/efeitos dos fármacos , Colo/patologia , Colo/ultraestrutura , Defecação/efeitos dos fármacos , Modelos Animais de Doenças , Estresse do Retículo Endoplasmático/efeitos dos fármacos , Comportamento Alimentar/efeitos dos fármacos , Flavonoides/análise , Laxantes/farmacologia , Masculino , Modelos Biológicos , Fenóis/análise , Ratos Sprague-Dawley , Saponinas/química , Saponinas/farmacologia
An analytical method based on UFLC-QTRAP-MS/MS was established for simultaneous determination of thirty-three components including steroidal saponins, homoisoflavonoids, amino acids and nucleosides in Ophiopogonis Radix. Thirty-three target components of commercial medicinal materials of Maidong were comparative analysis. Synergi™ Hydro-RP 100î¦ column (2.0 mm × 100 mm, 2.5 µm) was used with 0.1% formic acid solution-0.1% formic acid acetonitrile for gradient elution at a flow rate of 0.4 mL·min⻹. In addition, multiple reaction monitoring (MRM) mode was employed. The data were comprehensively processed and analyzed with hierarchical clustering analysis(HCA), principal component analysis(PCA) and partial least squares discriminant analysis(PLS-DA) methods. All components showed good linearity(r>0.999 0) within the tested ranges. The average recoveries were between 96.23%-102.0%, and the relative standard deviation(RSD) were less than 5%. The results showed that there were significant differences in components between Ophiopogonis Radix and Liriopes Radix, with seven components obviously different. This method was useful for providing basis for the comprehensive evaluation and intrinsic quality control of Ophiopogonis Radix and Liriopes Radix , and may provide a new method reference for the identification of Ophiopogonis Radix and Liriopes Radix.
AssuntosMedicamentos de Ervas Chinesas/análise , Liriope (Planta)/química , Ophiopogon/química , Saponinas/análise , Cromatografia Líquida de Alta Pressão , Compostos Fitoquímicos/análise , Raízes de Plantas/química , Espectrometria de Massas em Tandem
O. japonicus and L. spicata var. prolifera are distinguished as sources of highly promising yin-tonifying medicinals, namely Ophiopogonis Radix and Liriopes Radix. Liriopes Radix is generally medicinally used as a substitute for Ophiopogonis Radix in various prescriptions due to their extremely similar nature. Ophiopogonis Radix and Liriopes Radix are both very rich in bioactive polysaccharides, especially ßfructans. Over the past twelve years, except for work on physical entrapment and chemical modification of obtained ßfructans, the vast majority of studies are carried out to investigate the bioactivities of O. japonicus polysaccharides (OJP) and L. spicata var. prolifera polysaccharides (LSP), mainly including anti-diabetes, immunomodulation, anti-inflammation, antioxidation, anti-obesity, cardiovascular protection, etc. In addition, OJP and LSP are considered to have the potential to regulate intestinal flora. The main purpose of this review is to provide systematically reorganized information on structural characteristics and bioactivities of OJP and LSP to support their further therapeutic potentials and sanitarian functions.
AssuntosLiriope (Planta)/química , Ophiopogon/química , Polissacarídeos/uso terapêutico , Animais , Humanos , Polissacarídeos/química
The study identified the main morphological index of the seedlings classification including seedling age,the root width and number of newborn buds and coarse roots, according to the local agricultural production techniques and assessment of Liriope spicata's growth and development condition. After carrying on K cluster analysis of the morphological, we separated the seedlings into two levels. The first level (â )ï¼ the new talent with the root width exceeding two point five millimeters, the new born buds exceeding three, and with the coarse root exceeding one. The second level (â ¡)ï¼ the old talent with the root width below one millimeters, the newborn buds below two and without coarse root. The study surveyed the plants' growth index dynamics, as well as the yield and quality of the tuberous root. The experimental results suggested that the growth condition of seedling â was better, the yield of earthnut higher, the quality of earthnut more excellent. The study lied the foundation of L. spicata's grading standards and standardized production.
AssuntosLiriope (Planta)/crescimento & desenvolvimento , Plântula/crescimento & desenvolvimento , Raízes de Plantas/crescimento & desenvolvimento
Liriope spicata (Thunb.) Lour has a unique LsEPSPS structure contributing to the highest-ever-recognized natural glyphosate tolerance. The transformed LsEPSPS confers increased glyphosate resistance to E. coli and A. thaliana. However, the increased glyphosate-resistance level is not high enough to be of commercial value. Therefore, LsEPSPS was subjected to error-prone PCR to screen mutant EPSPS genes capable of endowing higher resistance levels. A mutant designated as ELs-EPSPS having five mutated amino acids (37Val, 67Asn, 277Ser, 351Gly and 422Gly) was selected for its ability to confer improved resistance to glyphosate. Expression of ELs-EPSPS in recombinant E. coli BL21 (DE3) strains enhanced resistance to glyphosate in comparison to both the LsEPSPS-transformed and -untransformed controls. Furthermore, transgenic ELs-EPSPS A. thaliana was about 5.4 fold and 2-fold resistance to glyphosate compared with the wild-type and the Ls-EPSPS-transgenic plants, respectively. Therefore, the mutated ELs-EPSPS gene has potential value for has potential for the development of glyphosate-resistant crops.
AssuntosGlicina/análogos & derivados , Liriope (Planta)/genética , Reação em Cadeia da Polimerase/métodos , Glicina/farmacologia , Resistência a Herbicidas/genética , Liriope (Planta)/efeitos dos fármacos , Mutação , Proteínas de Plantas/genética , Plantas Geneticamente Modificadas/efeitos dos fármacos , Plantas Geneticamente Modificadas/genética
Structures and in vitro hypoglycemic activities of polysaccharides from different species of Maidong were studied. The primary structures of polysaccharides were elucidated on the basis of GC, GC-MS, infrared, NMR and periodate oxidation-Smith degradation. Liriope spicata polysaccharide (LSP), Ophiopogon japonicus polysaccharide (OJP) and Liriope muscari polysaccharide (LMP) were composed of ß-fructose and α-glucose. The average molecular weights of LSP, OJP and LMP were 4742, 4925 and 4138Da with polydispersity indexes of 1.1, 1.2 and 1.1, respectively. The backbones of polysaccharides were formed by Fruf-(2â, â2)-Fruf-(6â, â6)-Glcp-(1â and â1, 2)-Fruf-(6â with a molar ratio of 5.0:18.2:1.0:5.3 (LSP), 6.8:15.8:1.0:5.8 (OJP), 8.3:12.3:1.0:3.9 (LMP), respectively. The RT-PCR and western blot analysis indicated that LSP, LMP and OJP increased the expression of PI3K, AKT, InsR, PPARγ and decreased the expression of PTP1B in mRNA level and protein level in IR HepG2 cells. Furthermore, glucose consumption was increased after treated with polysaccharides. These results revealed that LSP, OJP and LMP had potential anti-diabetic effects.
AssuntosHipoglicemiantes/farmacologia , Liriope (Planta)/química , Ophiopogon/química , Polissacarídeos/farmacologia , Células Hep G2 , Humanos
Vinorelbine (NVB) is a semi-synthetic vinca alkaloid that is approved for the clinical therapy of lung cancer. However, the clinical application of NVB was limited because of the acquisition of resistance and inacceptable toxicity. Therefore, it is of great interest to develop low-cytotoxic drugs that can synergize with NVB. DT-13, a saponin monomer 13 of the Dwarf lilyturf tuber, showed inhibitory effects on tumor metastasis and angiogenesis in the previous studies. Here, we found that DT-13 combined with NVB exhibited synergistic effect to inhibit the cell proliferation in human lung cancer NCI-H1299 cells rather than human embryonic lung fibroblasts WI-38. The combination of DT-13 and NVB significantly inhibited the colony formation, induced cellular and nuclear morphological changes, and triggered cell cycle arrest at mitotic phase. Furthermore, MAPK signaling pathway was activated by the combination treatment, and the activation of ERK was required for the induction of mitotic arrest. Taken together, DT-13 combined with NVB exhibited synergistic anticancer effect in NCI-H1299 cells, and DT-13 may be a candidate agent for adjuvant chemotherapy of NVB in lung cancer.
AssuntosLiriope (Planta)/química , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Mitose/efeitos dos fármacos , Saponinas/farmacologia , Transdução de Sinais/efeitos dos fármacos , Vimblastina/análogos & derivados , Ciclo Celular/efeitos dos fármacos , Linhagem Celular , Linhagem Celular Tumoral , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Sinergismo Farmacológico , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/metabolismo , Proteínas Quinases Ativadas por Mitógeno/metabolismo , Neovascularização Patológica/tratamento farmacológico , Neovascularização Patológica/metabolismo , Vimblastina/farmacologia , Vinorelbina
Liriope (Liliaceae) species have been used as folk medicines in Asian countries since ancient times. From Liriope plants (8 species), a total of 132 compounds (except polysaccharides) have been isolated and identified, including steroidal saponins, flavonoids, phenols, and eudesmane sesquiterpenoids. The crude extracts or monomeric compounds from this genus have been shown to exhibit anti-tumor, anti-diabetic, anti-inflammatory, and neuroprotective activities. The present review summarizes the results on phytochemical and biological studies on Liriope plants. The chemotaxonomy of this genus is also discussed.


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Knightstown, IN Natural Gas Rates
Natural Gas Rates in Knightstown
^ Year over year, the average residential natural gas rate in Knightstown increased 18.77 percent. [Read More]
Natural Gas Usage in Knightstown
^ Knightstown residents used an estimated 2 million cubic feet of natural gas in May 2022. [Read More]
Natural Gas Customers in Knightstown
^ There are an estimated 604 residential natural gas customers in the town of Knightstown. [Read More]


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Photo tour starting from Sorrento to reach Piazzale Murat in Massa Lubrense. You will discover places that haven't been yet contaminated by mass tourism and immersed in nature. Ancient villages, historical villas, green landscapes, a crystal clear sea, and an amazing view of the Gulf of Naples and the island of Capri will be a perfect background for your pictures.
A unique tour at the discovery of the hidden beauties of our land.*
*The tour is customizable. Upon request and depending on our availability, we can design a tailor-made version of the tour. The price will change accordingly.
Duration: 2 hours approx
Departure times: 8:00am; 11:00am; 5:00pm
- Free pick up from your accommodation (pick-up available from Massa Lubrense town, Sant'Agata, Sorrento, Sant'Agnello, Piano di Sorrento, Meta)
- Polaroid photo and souvenir photos with Fiat 500
- Bottle of water
- All photos sent via Airdrop, Whatsapp, e-mail
The customer must show a valid passport or identity card
- The car is private and for a maximum of 2 guests
- Not recommended for pregnant women
- For safety reasons, the tour is not accessible to babies or your children
- Cancellations made 7 days or more in advance of the event date will receive a 100% refund.
- Cancellations made within 24 hours of the event will receive a 50% refund.
- No shows: No refund granted
€ 230,00


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Who tries to self-improve after an academic failure?: trait self-esteem differences and the mediating role of self-esteem distancing processes
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Carpet Installation Service in Forest Grove OR, 97116
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90 West Wieuca Road NE - Office Space Availability
90 W Wieuca Rd NE, Atlanta, GA 30342
- For Lease Contact for pricing
- Property Type Office
- Property Size 24,000 SF
- Lot Size 1.84 Acre
- Year Built 1972
- Date Updated Sep 15, 2020
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- Walk Score ® Somewhat Walkable (70)
- Transit Score ® Some Transit (33)
- Bike Score ® Bikeable (57)
- City Atlanta, GA
- Neighborhood East Chastain Park
- Zip Code 30342
Frequently Asked Questions
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90 West Wieuca Road NE totals 24,000 square feet.
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90 West Wieuca Road NE was built in 1972.
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Looked for this email for too long. I switched to Outlook a couple of months ago because the search worked better. This morning, it couldn't find its email with both hands.
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and the search results:
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Opened Mail, and it found it immediately.
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