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Lay down new property roots
National Property Auction
Thursday 31st March 2022 at 10:00am
You can find the addendum for this month's auction by taking a look at the link below.
The addendum is where you can find any last minute updates or changes to the lots on offer – it will be updated up until auction day, so if you're bidding on Thursday, make sure to regularly check back to stay in the know.
Welcome to your March
auction catalogue
Andrew Parker
Managing Director & Auctioneer at
SDL Property Auctions
It's my pleasure to launch the catalogue for our March National Property Auction, taking place on Thursday 31st March – if you didn't find your property match in February, maybe you'll be able find a blooming opportunity this month?
As we move into spring with a new financial year approaching, you may be considering moving onto pastures new or adding to your existing property portfolio. This month's catalogue has a great variety of opportunities, including substantial period properties and quaint countryside bungalows.
Regardless of whether you're looking to buy or sell over the next few months, there are some important home maintenance tips that are best looked at in the spring months that will come in handy – no matter if you're moving in or out! We've put together a handy guide below with some advice on the best steps to take.
With plenty of properties for you to browse through this month, simply use the view all lots button at the end of this section to see the full range of 205 properties on offer and see if any of them plant any ideas in your head.
If you're in the market for a small-scale investment, then lot 102 in Hartlepool could be right up your street. Flat 21 in Marina View is a one bedroom, top-floor apartment with views out across Hartlepool. It has recently become vacant, however has recently been generating in excess of £4,500 per annum in rental income. Coupled with the fact that there is no service charge applicable to the property, makes this an ideal investment opportunity, producing a 23% yield against the guide price of just £19,500+ (plus fees).
Lot 102
- Flat 21, Marina View, 80 Church Street, Hartlepool TS24 7DN
- Guide price*
- £16,500+ (plus fees)
A more substantial rental investment can be found with lot 38 in Leicester, at 58 Fosse Road South. This is a tenanted, four-bedroom property in a very popular, convenient location. Set out over three floors, it offers spacious accommodation while retaining a number of its original period features. Currently let at £690pcm to a longstanding tenant, this would make a great purchase for any landlord looking to add to their portfolio, with a guide price of £175,000+ (plus fees).
Lot 38
- 58 Fosse Road South, Leicester, Leicestershire LE3 0QD
- Guide price*
- £175,000+ (plus fees)
Anyone looking for a development project will be sure to take a look at lot 120, 96 Osmaston Road in Derby. Melbourne House is a sizeable Grade II listed property in a prominent position for the city centre, dating back to the late 1800s (as evidenced by its late Victorian Gothic style). It sits on a private gated plot extending to approximately 0.37 acres as well as a separate garage and 37 parking spaces. It has incredible scope, with significant potential to convert into an HMO, self-contained apartments or even a business premises, all subject to obtaining the usual planning consents. With a guide price of £595,000+ (plus fees), this could present itself to be a lucrative investment for the right buyer.
On the other hand, in Nottingham, there is the chance to acquire the site of the Former Canning Circus Police Station in The Park area of the city – lot 11. It has full planning permission (20/00731/PFUL3) for the creation of eight luxury residential units, with nine units potentially being possible subject to planning permission being granted. A scheme of this size could have a GDV of circa £3,000,000 subject to a high specification on completion of the development. With the site being offered at a guide price of £550,000+ (plus fees), one lucky buyer could have a substantial return on investment on their hands.
Lot 11
- Former Canning Circus Police Station, The Park, Nottingham NG7 1LS
- Guide price*
- £550,000+ (plus fees)
If you're interested in bidding in this month's auction, you will need to register before midday on Wednesday 30th March – to do so, simply head to our quick and easy online form here. It'll take no more than a few minutes to complete and costs nothing to sign up.
There's also a handy guide below which takes you through all our remote bidding options: online, on the phone and by proxy, so that you can bid in the way that you're most comfortable with.
Our next National Property Auction is on Thursday 31st March 2022 and if you're interested in selling by auction take a look at our frequently asked questions or contact our friendly team on 0800 046 5454.
Frequently asked questions
Over the past few months we have naturally received some questions from our bidders about how the buying process works. Largely we are operating as we always have been, we're simply not able to see you in the auction room when you bid. We've put together these frequently asked questions to help guide you through your auction purchase.
A reserve price is the price stated as the lowest acceptable figure by the seller. This figure is confidential between the seller and auctioneer.
No, not always. The guide is an indication given by the auctioneer. Where the guide price is a bracket figure, the reserve cannot exceed the top end of the bracket price. If the guide price is a single figure, then the reserve can be up to 10% in excess of this.
After the auction has ended one of our team will contact you to advise you of the result.
Yes, and these vary depending on the method of sale associated with the property and the country in which you are purchasing. These are listed below – please note the reservation fee does not contribute towards the purchase price. Any further additional costs, which are payable in addition to the purchase price will be included within the Special Conditions that are attached to the Contract. Therefore all prospective purchasers must inspect the legal packs thoroughly. We also strongly advise prospective purchasers to request a legal representative reviews the pack for every lot that you may wish to bid on, so that you are fully aware of any additional costs, if applicable.
England and Wales
Unconditional with Fixed Fee: On the fall of the hammer, the successful bidder will be legally bound to purchase the property. The successful bidder must immediately exchange contracts and pay a 10% deposit (subject to a minimum of £5,000), along with a non-refundable Buyer's Fee. The Buyer's Fee is £1,074, and completion must take place within 20 business days, unless the Special Conditions of Sale state otherwise.
Unconditional with Variable Fee: On the fall of the hammer, the successful bidder will be legally bound to purchase the property. The successful bidder must immediately exchange contracts, pay a 5% deposit (subject to a minimum of £5,000) along with a non-refundable Buyer's Fee of either 4.8% of the final sale price of the property up to and including £250,000, or 3.6% if the final sale price is over £250,000. The Buyer's Fee is subject to a minimum of £6,000. Completion must take place usually within 20 business days unless the Special Conditions of Sale state otherwise.
Conditional with Reservation Fee: On the fall of the hammer, the successful bidder will enter into a Reservation Agreement with the seller and be granted an exclusivity period of 40 business days to purchase the property (unless the Special Conditions of Sale specify a different timescale). The successful bidder must use the exclusivity period to proceed to exchange of contracts and complete the purchase. On the fall of the hammer, the successful bidder must immediately pay a non-refundable Reservation Fee of 4.8% of the final sale price of the property up to and including £250,000, or 3.6% if the final sale price is over £250,000. The Reservation Fee is subject to a minimum of £6,000.
Unconditional with Fixed Fee: On the fall of the hammer, the successful bidder will be legally bound to purchase the property. The successful bidder must immediately exchange contracts, pay a 10% deposit (subject to a minimum of £5,000) along with a non-refundable Buyer's Fee. The Buyer's Fee is £1,074, and completion must take place within 20 business days, unless the Special Conditions of Sale state otherwise.
Unconditional with Variable Fee: On the fall of the hammer, the successful bidder will be legally bound to purchase the property. The successful bidder must immediately exchange contracts, pay a 5% deposit (subject to a minimum of £5,000) along with a non-refundable Buyer's Fee of 3.6% of the final sale price of the property, subject to a minimum of £4,000. Completion must take place usually within 20 business days unless the Special Conditions of Sale state otherwise.
Conditional with Reservation Fee: On the fall of the hammer, the successful bidder will enter into a Reservation Agreement with the seller and be granted an exclusivity period of 40 business days to purchase the property (unless the Special Conditions of Sale specify a different timescale). The successful bidder must use the exclusivity period to proceed to exchange of contracts and complete the purchase. On the fall of the hammer, the successful bidder must immediately pay a non-refundable Reservation Fee of 3.6% of the final sale price of the property, subject to a minimum of £4,000.
There are a number of options when selling by auction which can include paying no fees at all and having the buyer an additional fee instead.This is often an attractive option when you are selling due to a bereavement or a divorce and you have limited cash prior to the auction to fund the sale. Alternatively as a seller you can pay an initial fee and commission price for the sale of the property, meaning the buyer doesn't have to pay anything extra, maximising the final sale price of the property
Regardless of which auction route is selected, there are solicitor fees to prepare the legal pack for your property, which typically costs around £350 to £500. After your home is sold, you will also need to instruct a solicitor for the conveyancing of the property, which can cost anywhere from £450 to £750.
Yes, if a reserve price is not met during the bidding process, then the lot will not sell. We continue to market our unsold properties after the auction and if a post-auction sale is agreed it will be carried out under auction conditions.
Bidding registration
Bidding registration closes at midday the day before the auction.
Registering to bid in one of our National Property Auctions is quick, easy and painless. By completing our online form, you can register for bidding online, on the phone and by proxy, meaning you can bid from the comfort of your own home. There's no need to wait for the legal pack to be completed before registering, there's no obligation to bid on the day and there's no money taken prior to bidding.
7 ways to give your
property a
Spring – is there any other season in which the Great British weather can be any more unpredictable? One minute you may be wishing you hadn't turned the heating off when an unexpected cold-snap returns, next you'll be out in the garden with a glass of Pimms and a bowl of strawberries! With this in mind, it's best to make sure your home is in tip-top condition, enabling you to be prepared for any forecast and the incoming warmer months.
- Check out the roof
As the weather starts to warm up, there's no better time to give your roof a once over. Remember to be careful if using a ladder and if you have any concerns, don't hesitate to contact a professional. Be sure to look out for any missing or damaged tiles, or any other signs of leaks or cracks. Depending on your type of roof (whether its flat or pitched, clay or concrete) will effect the price of any repairs, but they tend to range from as little as £100 for 1m2 on a flat roof, to around £1500 for a 10m2 for a pitched (clay) and felt roof.
- Give the gutters some TLC
While you're up checking your roof, you may notice that your gutters need a smidgen of attention. They've probably taken on their fair share of leaves and debris over the winter, so clear these out of the guttering and any downspouts. If anything has come loose, reattach them or consider replacing them if they're looking a little worse for wear. Gutters that aren't regularly cleared, can hamper rainwater drainage and cause long term damage such as rotting fascia boards, water damage to walls and ceilings and, in the worst cases, foundations, so make sure to take a look at yours when you get the chance.
3. Check your outside taps
With temperature changes during winter often being quite severe, with bitingly cold spells at times, make sure to test any outside taps or plumbing works by letting them run. Take a look for any signs of leaking, and check the flow by placing your finger over the opening – if it stops, it's best to get in touch with a professional to check your pipes as this may be a sign of a harder to fix issue. As with your gutters, water leaks in or outside of your property can cause major damage if left unchecked, so be sure to get anything you're not sure about properly inspected.
4. Treat your woodwork (literally!)
As the weather warms up, chances are you'll be spending more time outside your property, so take a look at any woodwork – everything from rails and fences to garden furniture – to make sure it's still in good condition. Wood is naturally prone to decay and rot if left alone, so at the very least, it's a safety concern to ensure everything is still in good condition. Any tired looking wood can usually be perked up with a good pressure washer, then a treatment with a good wood oil will help to prolong its life.
5. Get some fresh air inside
As it starts to warm up, it's far more pleasant to get some windows open and get some fresh air inside without needing to put a few extra layers on. Getting a good flow of fresh air into your home will help to get rid of any stagnant air inside and help to, quite literally, freshen things up. While you're at it, use it as an opportunity to clean any windowsills which may have picked up some dust during the colder months.
6. Conduct any routine home safety checks
This is especially important if you've bought a property to let out as there'll be a number of safety checks you'll be legally required to provide evidence of before tenants can move in, especially if you're looking to develop an HMO. Make sure any smoke alarms are fitted (and wired to the mains if necessary) and have an engineer visit the property to provide a gas safety certificate. If there are any other mains supplies that you have concerns over, it's best (and safest!) to get a professional involved.
7. Consider any further upgrades
Whether you're moving into your property or not, this is a great time to consider any further updates to your property, giving you the chance to make it more energy efficient in plenty of time before the thermometer begins to dip again. Take a look at all the options available to you, including any additional insulation that can be fitted, the condition of your external doors and windows, installing smart-home solutions such as lightbulbs and thermostats and any other eco-friendly solutions. They may come at an expense initially, but will help to improve your property's value – both on the open market and its potential rental income.
Remember, for any work you're not comfortable completing yourself, make sure to get in touch with a professional – otherwise, happy spring cleaning!
Remember to tune in!
Our Auction Events are broadcast online, live from our auction studio in Nottingham.
It's really easy to tune in and watch on the day. The auction begins at 10:00am and will run throughout the day, with our each of our auctioneers taking to the rostrum. Simply visit our website where you'll be able find a link to the auction on the day or follow the link below!
Our buyers terms
If you're planning on bidding at auction, it's really important that you do your due diligence prior to the auction – part of which is reading our buyers terms which you can find below. Make sure to read them in full to ensure you're prepared to bid.
Guide to additional fees
Important notice relating to fees, costs and charges payable by the buyer in addition to the purchase price.
In addition to the purchase price, buyers may be required to pay additional fees, costs and charges. These may include, but are not limited to, Value Added Tax (VAT), Stamp Duty, ground rents, rent arrears/apportionment of rent, outstanding service charges, sellers search costs/disbursements, reimbursements of sellers solicitors, auctioneer costs or reservation fees. All prospective buyers are advised to inspect the legal documents including the contract and special conditions of sale and seek their own independent legal advice as to the full cost of purchasing a specific property.
Homes under the Hammer
If you're successful in this month's auction, you could take part!
Despite the current restrictions the Homes under the Hammer team are still looking for properties to feature in upcoming episodes of the show, even though they can't be in the auction studio. If you're interested in taking part in the programme or would like any information about what is involved in taking part please contact either David Cook on 07814 079910 or Mal Nichol on 07929 829814 or alternatively use the button below to contact them via email.
Legal Packs
We recommend reading the legal pack prior to the auction, to make sure you're aware of all the information before bidding.
It's really important that you take a thorough look through the legal pack for the property you're interested in buying before placing a bid, as they lots of important information regarding your purchase. We recommend going through the pack with your solicitor prior to the auction. You can view the legal packs for all lots in this month's auction using the link below.


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One of the terrible things that could happen to you is being injured in an accident. Whether you are involved in an automobile collision, a slip and fall accident or other accidents caused by someone else's negligence, the physical, emotional and financial consequences cannot be overlooked.
Depending on the extent of the injury, you will suffer for a long time, be likely to miss work and earn money to live on, and unable to enjoy the things you used to do. This is where filing a personal injury lawsuit comes in. If you believe someone else should be held responsible for your accident, you may be eligible to sue the party allegedly at fault. Also, if you are pursuing a lawsuit, you should know that you have certain rights to assert and be protected.
You will find below your rights in the event of bodily injury:
Right to seek prompt medical care
This is one of the common rights you have in a personal injury case. Essentially, seeking immediate medical attention after the accident plays a crucial role in your legal action. It allows you to document your injuries and prove that they resulted from the accident. Your doctor will give you a written diagnosis and treatment plan during your exam.
Once you have decided to file an injury claim, you can exercise this right by requesting copies of these medical reports and adding them to your list of evidence. This can help strengthen your legal action.
Right to recover compensation
In addition to holding the defendant responsible for what happened, you also have the right to recover compensation in a personal injury case against the responsible party. This compensation will cover expenses and other losses due to your accident and injuries. These can include hospital bills, loss of income and ability to work, pain and suffering, and other similar losses.
But before you can be compensated, you must establish the negligence of the responsible party in your personal injury case. This is where an experienced personal injury lawyer from reputable legal networks like 1-800 injured becomes useful. They know what to do to prove that someone else's negligent acts caused your injuries. For example, they can assess the facts of your case and establish the essential elements of negligence. If they can prove it in court, you can now discharge your right to receive the compensation you deserve.
Right to collect evidence
It's not easy to have a successful personal injury case. But with your right to gather valuable evidence, you'll have a better chance of winning your case. As an injured party, you must collect information about the accident. These may include photos of the accident scene and damage to your vehicle, medical reports, records of employment, and other forms of documentation.
After gathering all the necessary documentation, you can now submit it to your attorney and have it included in your list of evidence. You can use the documents to improve the chances of obtaining a favorable result. Not only would you be compensated for your injuries, but you would also be hold the negligent party liable for the accident.
Right to negotiate with the insurance company
No matter what type of accident you are involved in, the party allegedly responsible for your injuries is more likely to be insured. In this case, you have the right to deal with the insurance company to get the settlement offer you deserve. However, negotiating with the insurer can be tricky because they usually prioritize their interests over yours. As a lucrative business, insurance companies would do anything to reduce the settlement amount or deny the claim upfront on certain grounds. For example, they could use anything you say against yourself to justify reducing or denying your claim.
Due to these circumstances, having a lawyer on your side is essential. Unless you have excellent negotiation skills, you should hire a legal professional to negotiate with the insurance service provider while protecting your rights. Since most personal injury companies know how insurance companies work, they would be reluctant to do anything that could get them in huge legal trouble.
Therefore, if you exercise your right to negotiate with the insurance company, you can also seek the help of a legal expert to achieve a more desirable outcome.
Final Thoughts
Recovering from an accident is never easy. There are several things to consider to ensure you get back on your feet as quickly as possible. But in addition to your physical recovery, you also have to deal with the legal aspect of your situation, which involves filing a personal injury lawsuit.
Fortunately, dealing with an injury case doesn't have to be difficult as long as you know how to enforce the aforementioned rights. The more you are aware of your rights, the better you will be able to navigate your file and obtain a winning judgment.
Jacob Maslow
Legal Scoops editor Jacob Maslow founded several online journals, including Daily Forex Report and Conservative Free Press.

subset: commoncrawl


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What is the duty of legislation in society? A lawful theory should try to answer these concerns by identifying the characteristics of law and also the capability of individuals to follow regulations. This would include a theory of legislation that concentrates on the normative limits of the exercise of coercive power. Nevertheless, law has a lot more elements to it than its lawful content. Below are four methods which legislation can be utilized to boost culture. As well as do not neglect to share your thoughts with us in the comments area!
Laws are made and enforced by federal governments. People have to follow them or deal with prison time as well as fines. Regulations can be used to refer to one details collection of regulations, or to the whole body of regulations in a nation. As an example, stating that murder is against the regulation indicates that it is not permitted in a certain geographic region. This likewise puts on agreements and adjudication contracts. A legal agreement is an agreement that is enforceable by a court or another entity.
Whether a regulation is based on a political system, a constitution, or something else, the legislation plays an essential function in preserving a healthy society. It helps preserve the status quo, shield minorities, and advertise social justice as well as order. Various legal systems serve these objectives much better than others. As an example, tyrannical governments oppress political opponents and also minorities. The lawful system of colonial nations usually imposed tranquility on countries by imposing legislations based on their own values and choices.
In the United Kingdom, a lawyer might be called a lawyer. These individuals represent their clients in court, and should finish particular educational requirements. They are then given the honorary title of Esquire. The title is usually made use of after an individual's name, as well as participants are picked based upon their exceptional academic efficiency. Yet the benefits of regulation institutions do not end there. You can likewise go after an occupation in an additional area of regulation that you have an interest in.
In other areas, religious beliefs can be utilized as a basis for regulation. For instance, Islamic Sharia is based on the scriptures, and Christian canon law is a judicial system based on the Scriptures. Yet even these systems require human elaboration. In Islamic Sharia, the Quran contains some law as well as acts as a resource for more regulation via thinking by analogy, Qiyas, and also Ijma.
In addition to these programs, law institutions also have a substantial very first year educational program. First-year students will generally take structure courses in the law, including civil procedure, jurisdiction, proof, household regulation, and professional duty. Hereafter, they'll take additional programs and also usually engage in monitored medical opportunities. Several law schools additionally offer trainees the chance to join various sorts of legal practice, consisting of representing the general public in court. And, as mentioned previously, law colleges offer a chance for trainees to pick up from the most effective of both worlds.
Along with the mandatory core programs, legislation schools likewise offer certificate programs, to make sure that pupils can concentrate on their interests. For example, ONU Legislation offers a certification track in criminal law, company law, and also tax obligation regulation. Some colleges also offer mix levels, like the JD/MSA program at ONU Legislation, where students gain a Master's level as well as a Juris Doctor. The combined levels enable pupils to sit for the certified public accountant examination while gaining their law level.
Eventually, law is necessary for preserving caste. Without laws, cultures would certainly have to rely upon self-protection or a federal banking system. Laws provide individuals a feeling of predictability and also protection. It likewise promotes wider social structures as well as higher efficiency. If legislation is done well, culture will certainly thrive. If you're unclear about the duty of law, consider all of the benefits that it can bring. When appropriately implemented, regulations can improve the lifestyle and also make it much easier for everyone.
Common law, or case law, is a system that bases choices by courts on the point of views of courts. It uses precedent to guide courts in determining comparable disagreements. By complying with criterion, courts will usually follow it, unless brand-new circumstances or perspectives make it reasonable to ignore it. It is this consistency and predictability that make common law so valuable. In the USA, the common law is frequently the governing law in civil issues. There are numerous various other ways in which it can enhance culture, but one of the most essential distinction between a civil law system and also a common law system hinges on its concept of precedent.
Statutes offer the structure for the resolution of disagreements and also create a system to bring a conflict prior to a neutral fact-finder. This is the main resource of legislation, but laws are not always appropriate to every circumstance, as well as often judicial choices need to be issued to analyze them. These decisions are referred to as case law, and they have the force of law. These instances develop the basis for the regulation, as well as are legally binding on all the celebrations to the case.
While these two kinds of lawful order share resemblances, the authors distinguish between them via their conceptualization of the two sorts of lawful order. A legal order occurs when standards are expressed as well as implemented with repeated interactions. In contrast, spontaneous order is an outcome of repetitive communication in the absence of external control. Inevitably, the law serves as a focal institution that chooses a stability in the caste. If the legislation does not offer a role as an intermediary in between individuals, it will not work.
A law is the main source of regulation, yet the power to pass it is booked to the elected lawmakers. One more form of legislation is judicial decision, which has the force of regulation. While statutes often cover every possible circumstance, they do not cover every single one. When a law stops working to cover a specific situation, the courts will make use of case law to translate it. Case law has the legal force of regulation, and it may likewise work as a rule for future conduct of individuals within the jurisdiction.
The common law, additionally referred to as case law, is based upon lawful precedents established by courts. It additionally draws on institutionalized opinions and also interpretations from judicial authorities. These criteria usually inspire brand-new regulation. The method of following criterion is called "gaze decisis", and also it guarantees that comparable situations will get to similar end results. In civil issues, the common law typically guidelines. The difference in between the two kinds of regulation lies in the extent of the common law.
Civil law is a wide branch of law. It is a set of lawful laws that regulate a certain city or province. It was created by lawmakers, and also is differentiated from all-natural or global legislation. The term is occasionally utilized to refer to nonreligious power, as opposed to clerical as well as military power. It is also distinct from criminal legislation, which is extra certain to a particular situation. This branch of law has its roots in medieval European nations, where it is originated from the Latin municipium. visit immigration site
An additional branch of regulation is election regulation. It takes care of the guidelines that regulate elections, and also is very important for equating the will of individuals into working democracies. Election regulation addresses such problems as ballot rights, event financing, access of political elections, and electing machines. Election law likewise addresses electoral fraud, and also the famous McLibel instance, which was the longest-running instance in UK background. While some areas of political election legislation may appear complicated, there is a large amount of information and resources readily available to sustain these issues.


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Is it worth paying for an escort? Ultimately, it is up to you to decide if the benefits of hiring an escort service outweigh the cost.
Nowadays, there are lots of alternatives for finding regional escort ladies in the Glasgow location. You can discover many online directory sites that provide the contact information for escorts in your location. You can likewise discover escort agencies that have websites and post their ads online.
When trying to find an escort service, you ought to think about the type of service that you want. There are several types of escort services, so you need to make certain that you discover one that satisfies your requirements. Some escort services may just use GFE services, while others might provide a broader variety of services. If you're searching for an affordable way to find an escort, you might want to think about utilizing an online directory site. A lot of these directories will allow you to view the profiles of local escort women. You can call the escorts straight through the directory and organize to fulfill them in person. If you're searching for a more individual experience, you may wish to think about utilizing an escort firm. These firms will generally have a site where you can see the profiles of the agency's escorts. You can likewise get in touch with the firm directly to set up a consultation.
If you're looking for a more discreet method to discover an escort, you may want to consider using a private escort service. These services will typically post their advertisements in online directories or by themselves websites. You can call the escorts directly through the service and organize to satisfy them personally. When you're ready to employ an escort, you need to always make the effort to check out the reviews of the escort services that you're thinking about. This will help you find the best service for your needs. You can likewise ask pals or member of the family for suggestions. When you finally discover an escort service that you have an interest in, you must always make certain to request for recommendations. You ought to also make sure to have a look at the firm's site to see if they have any complaints against them.
You should always make sure to pay attention to the terms and conditions of the service as soon as you have actually discovered an escort service that you're happy with. You need to constantly make certain that you comprehend the terms prior to you accept anything. Lastly, when you're ready to satisfy an escort, you need to always make certain to dress properly. You must always wear something that will make you feel comfy and confident. You ought to likewise make sure to bring along some money so that you can tip the escort. When looking for an escort service, you should consider the type of service that you want. There are numerous different types of escort services, so you need to make sure that you discover one that satisfies your requirements. Some escort services may just offer GFE services, while others might provide a wider range of services. If you're looking for a more discreet way to discover an escort, you may desire to think about utilizing a private escort service. When you're ready to work with an escort, you need to always take the time to check out the evaluations of the escort services that you're considering.
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Açucena Home by Tetro Arquitetura
A spot immersed in lush Atlantic Rainforest nature. A terrain stuffed with massive leafy timber, foliage, shrubs, birds, and wild animals. A difficult topography with a steep slope is attribute of the Nova Lima area in Minas Gerais. That is the place the place Casa Açucena is inserted.
The venture is a response to a delicate studying of the place. Within the first contact with this terrain, it's already evident the necessity to preserve its pure traits. The act of trying upwards, from the bottom to the cover of timber, elevated as much as fifteen meters above floor stage, was decisive for the creation of the idea. The way to construct in a spot with such steep topography, whereas sustaining the unique nature? The way to give the residents the day by day expertise of trying up and seeing the sky via the treetops. These had been the questions that guided all design selections.
The preliminary understanding that structure ought to mildew to the terrain, and never the opposite means round, was the start line. The home rises above the bottom and the animal and flora develops beneath. This system shapes itself by occupying the empty areas between the timber. No timber are eliminated. The topography shouldn't be modified. Artwork and Nature in excellent concord. From this level on, no selection or design determination was made by the style or will of the architect. All the things is a response and is meant to strengthen an idea.
The home, in its white shade, is a shock to those that arrive. Its randomly positioned black pillars mix in with the trunks. The home appears to drift. Its fluid plan, a results of this system's occupation among the many timber, and its openings and folds within the slab, to succeed in the view of the treetops, generate volumetry. The structure is harmoniously inserted subsequent to the pure vegetation however maintains its presence. Shock and novelty are values inherent to artwork. Casa Açucena presents itself as a white flower within the midst of nature.
Go to Tetro Arquitetura
– by Matt Watts


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Sheetland Lodge, Sheetland Road, Termonfeckin, Co. Louth
6 Bed
6 Bath
429 m²
- Sale Type: For Sale by Private Treaty
- Overall Floor Area: 429 m²
Stunning 6 bedroom detached residence situated on the Sheetland Road, Termonfeckin, Co. Louth. 'Sheetland Lodge' extends to an impressive c. 429 sq.m. (4,620 sq.ft.) and is located in a small rural area situated approximately 8 minutes drive from Drogheda Town and c. 15 minutes drive from the M1 Motorway. This family home offers well-proportioned and flexible living space with an abundance of natural light flowing through the residence. The property also boasts generous landscaped surrounding gardens that are immaculately maintained and offer complete privacy on its c. 0.86 acre site. Surrounded with many local amenities such as Baltray Golf Club, Seapoint Golf Course, GAA Pitch, School & Shops, the property is only a 5 min drive to the heart of Drogheda Town Centre. Briefly, this is a family home full of many fine features ideally located in a very sought after area. Viewing Is Highly Recommended. AMV - €690,000 - For Sale by Private Treaty Features 6 Bedroom Detached Property Additional Attic Rooms Built C. 2004 C. 0.86 Acre Site Extends to C. 429 sq.m. (4,620 sq.ft.) *Fibre Broadband PVC Double Glazing Throughout O-F-C-H Open Fire Septic Tank Main Water Supply Landscaped Gardens Throughout Fully Private Aspects Electric Security Gate Ample Parking Block Built Rear Garage Roller Shutter Fully Alarmed Accommodation Includes Entrance Hallway (6.50m x 2.83m) Reception (5.77m x 4.88m) Lounge (4.88m x 5.40m) Sitting Room (4.11m x 4.18m) Kitchen/Dining (8.66m x 3.93m) (2.72m x 2.63m) Utility Room (2.79m x 5.12m) (1.67m x 1.85m) Guest WC (0.95m x 1.53m) Bedroom 1 (3.75m x 4.32m) En Suite (3.66m x 2.05m) Bedroom 2 (3.75m x 2.50m) En Suite (1.42m x 2.16m) Bedroom 3 (3.73m x 3.97m) Bedroom 4 (3.57m x 2.91m) Office (2.98m x 3.40m) Main Bathroom (5.46m x 3.98m) 1st Floor Landing Bedroom 5 (6.70m x 5.25m) (3.17m x 3.88m) Walk-In-Wardrobe (3.10m x 3.35m) En Suite (2.45m x 3.11m) Bedroom 6 (5.70m x 4.93m) En Suite (1.28m x 4.66m) Storage Room (3.44m x 5.16m) Gym (3.27m x 5.20m) Building Energy Rating BER: C3 Viewing Details Strictly by appointment with the sole selling agent.
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Property Features
- 6 Bedroom Detached Property
- Additional Attic Rooms
- Built c. 2004
- C. 0.86 Acre Site
- Extends to c. 429 sq.m (4,620 sq.ft)
- PVC Double Glazing Throughout
- Landscaped Gardens Throughout
- Electric Security Gate
- Block Built Rear Garage
- Fully Alarmed
Termonfeckin Neighbourhood Guide
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Property Facilities
- Parking
- Alarm
- Oil Fired Central Heating
BER Details
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Chance The Rapper has released the official music video for "The Highs & The Lows," featuring Joey Bada$$. Watch now.
Starz is setting the stage for its next spinoff, "Power Book III: Raising Kanan." Get the scoop on the series and watch the teaser.
Rapper Joey Badass has reportedly damaged his eyes by staring at the solar eclipse without protective eyewear forcing him to cancel shows.


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SmartSense by Digi
SmartSense delivers data-driven IoT solutions for food safety, facilities monitoring, and supply chain visibility.
Information about SmartSense by Digi
Frequent questions about SmartSense by Digi
How many employees does SmartSense by Digi have?
What is SmartSense by Digi's industry?
Where is SmartSense by Digi headquarters located?
What is the website of SmartSense by Digi?
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Truven Health Analytics delivers unbiased information, analytic tools, benchmarks, and services to the healthcare industry.
Truweight is a research and nutrition-based healthcare company that helps people deal with weight loss through super foods.
QPID Health activates clinical intelligence from EHRs and other back end repositories.
Truveris is a technology company driving transparency, access and lower costs across the prescription drug ecosystem.
Legacy ER & Urgent Care is a hospital & health care company that offers emergency medical and urgent services.
Truth Initiative is a national public health organization.
Phonographic Performance Ltd. (PPL) owns, as assignee, and exclusively controls public performance rights and radio broadcasting rights
Legacy Ford is a new & used ford car dealer in Rosenberg, Texas offering parts and service and financing services.
QRails is a financial technology company, providing processing services to traditional issuers as well as new payment service providers.
Legacy Financial Advisors is a financial services firm that provides wealth management services.
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Hickey, G.L. and Grant, S.W. and Caiado, C.C.S. and Kendall, S. and Dunning, J. and Poullis, M. and Buchan, I. and Bridgewater, B. (2013) 'Dynamic prediction modeling approaches for cardiac surgery.', Circulation : cardiovascular quality and outcomes., 6 (6). pp. 649-658.
Background: The calibration of several cardiac clinical prediction models has deteriorated over time. We compare different model fitting approaches for in-hospital mortality after cardiac surgery that adjust for cross-sectional case mix in a heterogeneous patient population. Methods and Results: Data from >300 000 consecutive cardiac surgery procedures performed at all National Health Service and some private hospitals in England and Wales between April 2001 and March 2011 were extracted from the National Institute for Cardiovascular Outcomes Research clinical registry. The study outcome was in-hospital mortality. Model approaches included not updating, periodic refitting, rolling window, and dynamic logistic regression. Covariate adjustment was made in each model using variables included in the logistic European System for Cardiac Operative Risk Evaluation model. The association between in-hospital mortality and some variables changed with time. Notably, the intercept coefficient has been steadily decreasing during the study period, consistent with decreasing observed mortality. Some risk factors, such as operative urgency and postinfarct ventricular septal defect, have been relatively stable over time, whereas other risk factors, such as left ventricular function and surgery on the thoracic aorta, have been associated with lower risk relative to the static model. Conclusions: Dynamic models or periodic model refitting is necessary to counteract calibration drift. A dynamic modeling framework that uses contemporary and available historic data can provide a continuously smooth update mechanism that also allows for inferences to be made on individual risk factors. Better models that withstand the effects of time give advantages for governance, quality improvement, and patient-level decision making.
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(AM) Accepted Manuscript
File format - PDF (1293Kb)
|Publisher Web site:
|Date accepted:
|No date available
|Date deposited:
|28 June 2018
|Date of first online publication:
|19 November 2013
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Territory Development Manager
- Employer
- DR Newitt
- Location
- East Riding of Yorkshire
- Salary
- £20000.00 -£25000.00 + Bonus + Company Vehicle
- Closing date
- 25 Aug 2022
View more
- Contract Type
- Permanent
- Function
- Sales & Marketing
- Business Sector
- Other Business Sector
Job Details
Territory Development Manager
Global Drinks Brand
East Riding of Yorkshire Region– Base £25K + Bonus + Company Vehicle!
A well-known non-alcoholic drinks brand is currently expanding its Independent Retail Store sales team and our looking for a salesperson to cover convenience store accounts in Swansea and surrounding areas
The role will be responsible for maximising instore sales opportunities for the brand to expand its market share. This is a new team being developed after bringing the field sales team "in house" from a 3rd party agency.
The Role:
• Drive the distribution of the core drinks range in store
• Identifying new opportunities in store to increase brand presence and optimise sales
• Responsible for POS & merchandising instore
The Person:
• Experience in a merchandising or sales rep, role focused on retail accounts.
• An ability to find solutions, resilient and not afraid to challenge things
• Driver's license
Salary £25K + company car + bonus scheme (up to £6K)
If you are interested in this position then please forward a copy of your most up to date CV to firstname.lastname@example.com or call Nancy on 0131 220 8981
Job vacancies from DR Newitt DR Newitt provide recruitment services to the UK, Ireland, Middle East and Worldwide FMCG market, including manufacturing, engineering and technical jobs. Established as a recruitment agency in 2002, DR Newitt's experience of working with customers in these core markets enables us to be a key partner in the job supply chain.DR Newitt delivers permanent, contract and interim recruitment services via specialist divisions for:
- Executive Management Jobs
- FMCG Jobs
- Food Jobs
- Engineering Jobs
- Manufacturing Jobs
- Jobs in Pharmaceutical & Healthcare
- Scottish Jobs
For your perfect job, call or email us
Edinburgh Office 0131 226 5060
Manchester Office 0161 833 0181
Email us your CV to email@example.com
- Website
- http://www.drnewitt.com/
- Telephone
- 0131 226 5060
- Location
38 Melville Street
Apply for Territory Development Manager
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Filing a premises liability claim in NY: Don't miss these details
You have suffered a serious injury on someone else's premises and now need to get immediate medical attention. As you focus on your recovery, you need to consider whether you can hold the property owner/manager/occupant responsible for your condition. Top firms like the law offices of King Law can help you determine whether you have a premises liability claim, and it doesn't cost anything to consult an attorney for your case. Here are some more important details that you need to know about.
Don't delay in taking action
Like other states, New York also has a statute of limitations, which sets a deadline for filing injury claims. Your premises liability case is also a type of personal injury claim, and you need to take action within three years from the date of the accident. If you are filing a wrongful death lawsuit after losing a loved one in a freak premise accident, you need to initiate the proceedings within two years from the date of the person's death.
Evidence you may need
No matter whether you have a premises liability claim or any other type of accident case, you need to present proof in support of your case. In other words, the burden of proof is on you, not the authorities. For premises liability cases, you need evidence like –
- Your medical records, including your doctor's testimony that states that you were injured and are under their care.
- Images of the scene. If you managed to take pictures of the scene after the accident, you could present that as evidence for your case. You can also return to the accident scene to see if you can gather info. Sometimes, the property is under surveillance, and CCTV footage can offer more details.
- Witness statements. Like in the case of car accidents, witnesses also matter for premises liability claims. If there were people who saw the accident happen, you or your attorney can contact them for testimonies.
- Other types of evidence. For instance, if the accused had faced similar complaints in the past, your lawyer could use that to prove that they didn't take adequate precautions despite knowing about the hazard.
- Expert opinions and testimonials. Because premises liability cases are often so complicated, lawyers often rely on accident reconstruction experts for testimonies.
Now that you know the basics, get an attorney on board and ask them about the worth of your premises liability claim.


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Cooler synonyms and antonyms
Part of speech:
The definition of groovy is slang to describe something that is very good, fun, or nice looking.
calmer (related)
The definition of calm is someone or something who is peaceful and free from stress or worries.
The definition of a pen is a small yard or animal enclosure, or an tool used to draw or write with ink.
free (related)
(Hurling) The usual means of restarting play after a foul is committed, where the non-offending team restarts from where the foul was committed.
heatpipe (related)
thermo-electric (related)
Zalman (related)
waterblock (related)
Swiftech (related)
Alphacool (related)
A substance used in a heat cycle that undergoes a phase change between gas and liquid to allow the cooling, as in refrigerators, air conditioners, etc.
An appliance, cabinet, or room for storing food or other substances at a low temperature.
An institution for the confinement of persons convicted of minor criminal offenses.
Find another word for cooler. In this page you can discover 63 synonyms, antonyms, idiomatic expressions, and related words for cooler, like: colder, groovier, chillier, hoosegow, jug, slammer, calaboose, poorer, greater, neater and chiller.
Trending topics


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Womens T20 Challenge 2022 Supernovas vs Velocity Final Supernovas won by 4 runs and managed to retain her third title
Deandra Dottin's all-around performance helped Supernovas win the title for the third time by defeating Velocity by 4 runs in the 2022 Women's T20 Challenge Final that took place on Saturday. Prior to that, Supernova won this title twice in a row, in 2018 and 2019. Hitting first at MCA Stadium in Pune, Parole Dotin scored an impressive 62 run to score 165 for 7 after playing 20 overdrive and then restricting the pace to 161 for 8 of 20 overdrive. Deandra Dottin was named Man of the Match for her overall performance. At the same time, the winning supernova team received a prize money of 50 thousand rupees.
In response to the 166 supernova goal, Velocity started very poorly and the team lost five small points within 64 times in 11 times. Laura Wolfhardt was the team's top scorer, who scored 65 points unbeaten. Shefali Verma (15), Yastika Bhatia (13), Kiran Navgir (0), Natkan Chantham (6) and captain Deepti Sharma (2) could not do anything special for Velocity and after that the whole team managed to score only 161 points.
Speed needed 34 runs in the last two games to win the title, and Laura Wolfhart and Simran Del Bahadur were in a tuck. Both hitters partnered 44 throws on 19 balls to bring the pace closer to victory. But in the end, the team missed 4 runs. Wolfhart played undefeated innings of 65 passes on 40 balls with the help of five fours and three sixes. At the same time, Bahadur also won the hearts of the fans by playing the undefeated 20-round innings at 10 balls with the help of three fours and sixes. At the same time, Pooja Vastrakar also achieved success.
Related news
Earlier, Supernovas set a 166-round goal for victory against Velocity. The two-time Supernova champion scored 165 goals against 7 points after playing 20 complete times. Diandra Dottin has played an amazing half century in the supernova. He played impressive 62-round innings on 44 balls with the help of one of fours and fours. Dottin shared 73 of 58 balls with Priya Punia on the first wicket and 58 passes of 36 balls for the second wicket with captain Harmanpreet Kaur.
Apart from Dotin, Captain Harmanpreet Kaur has played excellent roles 43 times with the help of 29 balls, one fours and three sixes. Meanwhile, Priya Punya scored 28 passes in 29 balls with the help of sixty, and Pooja Vastrakar scored five runs. For Velocity, Kate Cross, Simran Dil Bahadur and Deepti Sharma took two shares each while Ayabonga Khaka took one share.


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When suffering from fatty liver disease, many patients cannot avoid being confused and worried about the affected health condition. Therefore, in addition to following the treatment regimen, many people also find many different methods to support, hoping for remission.
One way many patients believe that is to treat fatty liver with cilantro. So this method really works or not, and if so, how to use cilantro to treat diseases effectively?
What Is Vegetable Cilantro?
For patients with fatty liver disease and at high risk of the fatty liver often apply herbs from cilantro to drink daily with the desire to improve liver function and maintain health, many cases have given the effect is very positive.
Cilantro is a popular vegetable in Vietnam, often present in family meals, used as a seasoning vegetable in soups.
Cilantro is also known with other names such as braised cilantro, cilantro, cilantro, deaf cilantro, in some places it is also known as dragon ball.
Cilantro has the scientific name is Limmophila Chinensis, the average tree is about 20 – 25cm, grows in wetlands in the swamps. Cilantro belongs to the herbaceous family, has a tall, cylindrical body, soft and spongy, with a hairy outer shell.
According to traditional medicine, cilantro is cool, spicy, slightly acrid, and has a fragrance, therefore it has a heat and detoxifying effect.
Besides, it is also effective in relieving pain and inflammation very well. Thanks to these wonderful properties that many people often apply to treat fatty liver with cilantro.
Some other remedies from cilantro are used in traditional medicine, such as to disinfect the intestines, in combination with other drugs to treat kidney stones, treat colic, support cancer treatment and also prevent aging.
Not only that, according to modern medicine, has also researched and found that cilantro has 92% water content, the rest is Vitamin B, C, carotene, limonene, and other active ingredients.
The most prominent of which are coumarin and flavonoid, these are two active ingredients that have very effective antibacterial and anti-inflammatory effects. Thus, the results show that eating cilantro is very beneficial for patients who are treating fatty liver.
Remedy for Fatty Liver With Cilantro
How to treat fatty liver at home that everyone can refer to with a remedy from cilantro is easy to implement, including 2 ways as follows:
The first remedy: Fresh cilantro and mint
It is necessary to prepare the following materials:
• Dried cilantro: 100gr
• Fresh mint: 100gr
• After the cilantro is dried, put it in a hot pan with yellow stars in the ground 3 times (roast until fragrant, then spread the stained vegetables onto the ground with a clean towel and pour the star vegetables evenly) for about 30-40 minutes.
• After that, continue using stained cilantro and peppermint with 100ml of filtered water and boil for about 10 minutes.
You should drink this water continuously for 5 days, the best time to drink is in the early morning when you have not eaten breakfast. Then at intervals, that is, stop the drug for 5 days and then continue to take it again, and so on until the disease improves.
One thing you should keep in mind is that the time to use cilantro juice to treat fatty liver is up to 1 month and abstain from using other mint-flavored remedies at the same time while drinking cilantro juice.
The second remedy: Cilantro and dried mint
For this remedy you need to prepare the following ingredients:
• Dried cilantro: 100gr
• Dried mint: 50gr
How to do: Dried cilantro and peppermint, you bring gold stars and then take down earth once. Then, continue to sharpen with 100ml of filtered water and boil for 10 minutes.
You need to take remedies to treat fatty liver with cilantro in this way continuously for 1 month. The best time to drink it every day after dinner is over.
You should also note that while using the drug it is necessary to abstain from seafood, animal organs, and fruits such as oranges, grapefruits, and tangerines. Besides, should supplement the fruits like pomegranate, sapodilla, ripe persimmon, soursop.
What to Watch Out For When Treating Fatty Liver With Cilantro?
The persistent treatment of fatty liver with cilantro will help the symptoms of the disease to be relieved thanks to the effect of liver detoxification and cholesterol reduction. From there, it helps restore and strengthen liver function.
However, because cilantro lives in the swamp, the stem will be covered with mud and impurities, so when using it, you must pay attention to wash it thoroughly to avoid the risk of infection or poisoning.
Cilantro only works to support treatment thanks to enhancing liver function, but can not completely treat fatty liver disease. Therefore, you should not overuse the use of cilantro which will lead to many side effects.
Pregnant women with fatty liver should not apply this method because it can lead to the dilatation of the visceral muscles, which is dangerous for both the mother and the development of the baby in the abdomen.
What Medications Are Effective For Fatty Liver Treatment?
Fatty liver is a condition where the amount of excess fat accumulated in the liver is 5% higher, causing impaired liver function and damage to the liver.
The general question of many people is that fatty liver can be treated?
Actually, there is currently no specific drug to completely treat fatty liver, but the treatment of fatty liver mainly depends on the cause of the disease to take measures to control and prevent dangerous complications.
Some of the most common causes of fatty liver are bad habits formed such as drinking alcohol, eating a lot of harmful foods, leading to overweight, obesity, diabetes or dyslipidemia. …
What medications does the fatty liver take? Thus, depending on the specific case, doctors will have their own regimen suitable for each stage of the disease and combine the treatment of fatty liver with drugs consisting mainly of amino acids, lecithin, choline … Help against fatty liver degeneration.
But overall, the best way to improve the condition is to control yourself in your diet, living in a scientific and healthy way. Along with that, it is necessary to increase sports training to increase health and prevent pathogens.
Currently, the optimal way to treat fatty liver is to combine modern medicine to treat fatty liver with medicine with traditional medicine through herbal remedies.
However, patients should not arbitrarily take drugs uncontrollably, but need to go to the hospital to be diagnosed, consulted, and treated in the most appropriate way.
Is There A Way To Find Fatty Liver Early?
Fatty liver affects a lot of health and quality of life. The treatment of fatty liver requires patients to persevere for a long time to be effective. Therefore, we need to live a healthy lifestyle to prevent pathogens.
If there are unusual symptoms of the body, the hospital should be diagnosed immediately.
Besides, to detect and treat fatty liver early you can register to perform a liver screening package if in doubt, or even when symptoms have not appeared.
Hepatobiliary screening should be done periodically or as soon as there are signs of illness that will help you:
• Conduct liver enzyme tests to assess overall liver function.
• Evaluate whether the secret function is working effectively or not.
• Screening for liver cancer at an early stage makes treatment effective.
• The tests will help screen for hepatitis B, C.
• Through ultrasound images to evaluate the hepatobiliary state.
• In-depth analysis of parameters related to liver function will evaluate the overall liver, detect the risks of liver damage, and early screening for hepatobiliary cancer.
If you are interested in liver screening to assess liver function, need advice and registration, you can call Diag's hotline 19001717 – Medical Laboratory and Diagnostic Center, one of the prestigious centers. and quality of service to be answered and consulted in the best way.
Thus, treating fatty liver with cilantro at home is a simple, low-cost method that helps to improve liver function effectively. However, you should be aware that cilantro does not have the ability to specifically treat fatty liver.
When there are abnormal signs of the body related to liver function or diagnosed with fatty liver, you need to go to the hospital to consult a specialist for accurate support and treatment from That brings the most positive effect besides using cilantro to treat diseases.
For more information about our test menu and price list, please click here.
The site cannot and does not contain medical advice. The medical information is provided for general informational and educational purposes only and is not a substitute for professional advice. Accordingly, before taking any actions based upon such information, we encourage you to consult with the appropriate professionals.


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How effective is Lynparza?
Official answerby Drugs.com
Key Points
- In the treatment of advanced or metastatic cancers, such as ovarian, breast (metastatic or early), pancreatic or prostate cancer, Lynparza has been shown in studies to lower or delay the risk of the disease progression and extend survival when compared to a placebo (an inactive pill) or another cancer treatment.
- Lynparza may be used if your cancer has a specific genetic marker (an abnormal "BRCA" or "HRR" gene). Your doctor will decide if you need to be tested for these genes.
- The effectiveness and study results of Lynparza are different for each patient group and cancer type. Not everyone will respond to treatment with Lynparza. Speak with your healthcare provider about your specific circumstances.
Lynparza (olaparib) is an oral medicine approved for the treatment of advanced ovarian cancer, fallopian tube cancer, and peritoneal cancer; breast cancer; pancreatic cancer; and prostate cancer that is metastatic (has spread in the body). It is also approved to as an adjunct to treat HER2-negative, high-risk early breast cancer with BRCA mutations.
How effective is Lynparza for ovarian cancer?
In advanced ovarian cancer, Lynparza can help keep ovarian cancer from growing or returning after you have had a response to platinum-based chemotherapy that you received before Lynparza.
- In women with a BRCA mutation who had responded to first-line platinum-based chemotherapy, Lynparza lowered the risk of the disease progression or death by 70%, when compared to a placebo (an inactive pill).
- Most women (61%, or 158 out of 260 women) did not see their cancer grow or return for a median of 3.4 years.
- In women with or without a BRCA mutation who had responded to second-line chemotherapy, Lynparza reduced the risk of disease progression or death by 65%, when compared to a placebo.
- Most women (136 out of 265 women) did not have their cancer progress for a median of 8.4 months compared to 4.8 months for women in the placebo group.
Lynparza has also shown positive results in other studies in women with advanced ovarian cancer when used with bevacizumab (Avastin). Talk to your doctor about Lynparza and how it may work for you.
How effective is Lynparza for breast cancer?
HER2-negative, metastatic breast cancer with BRCA mutations
Lynparza is used to help shrink or slow the growth inherited of BRCA-mutated, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body (metastatic).
You should have already received chemotherapy medicines, either before or after your cancer has spread. If you have hormone receptor (HR)-positive breast cancer, you should have been treated with hormonal therapy.
- In metastatic breast cancer, Lynparza delayed disease progression by 7 months compared to 4.2 months for patients who were given chemotherapy treatment.
- People treated with Lynparza were 42% less likely to have their cancer grow or spread than those on chemotherapy.
- In addition, 52% of people (87 of 167) saw their tumor shrink, compared to 23% (15 of 166) who received certain chemotherapy treatments.
HER2-negative, high-risk early breast cancer with BRCA mutations
- In the OlympiA Phase 3 study, woman and men had previous surgery and received chemotherapy either before or after their surgery. Some patients with hormone receptor–positive breast cancer may have also received hormonal therapy. In the study, 921 adults were treated with Lynparza and 915 were treated with a placebo (an inactive treatment).
- Results from the study showed that Lynparza reduced the risk of breast cancer returning by 42% when compared to a placebo (815 / 921 patients treated with Lynparza did not have their breast cancer return, compared to 737 out of 915 patients treated with placebo)
- Lynparza also reduced the risk of death by 32% versus placebo (a secondary endpoint).
How effective is Lynparza for pancreatic cancer?
Lynparza can be used as a maintenance treatment for patients with a form of pancreatic cancer that has abnormal genes (gBRCA mutations). It can be used when the cancer has not progressed after at least 16 weeks of first-line platinum-based chemotherapy.
- In one study, 92 patients received Lynparza and 62 patients received an inactive placebo. In the patients who received Lynparza, the cancer did not grow or return for 7.4 months, compared to 3.8 months for those who received a placebo.
- Lynparza reduced the risk of the cancer growing or returning by 47% when compared to a placebo.
How effective is Lynparza for prostate cancer?
Lynparza is also used to treat metastatic prostate cancer with certain inherited or acquired abnormal genes (HRR gene mutations) which no longer responds to previous treatments or surgery.
- In studies in men with BRCA1, BRCA2, or ATM gene mutations, Lynparza doubled the median time without cancer progression or death to 7.4 months, compared to 3.6 months with the hormone treatments enzalutamide (Xtandi) or abiraterone (Yonsa, Zytiga).
- Overall, 56 out of 162 men (35%) who took Lyparza did not have disease progression or death compared to 15 out of 83 men (18%) on enzalutamide or abiraterone.
- Thirty-three percent of men on Lynparza saw their tumors shrink compared to 2% of those on enzalutamide or abiraterone.
- Lynparza lowered the risk of death by 31% compared to enzalutamide or abiraterone. The median time that a patient lived after the start of Lynparza was 19.1 months compared to 14.7 months for patients taking enzalutamide or abiraterone.
What are the most common side effects with Lynparza?
- nausea
- fatigue (including asthenia)
- anemia
- vomiting
- diarrhea
- decreased appetite
- headache
- dysgeusia (altered taste)
- neutropenia (low numbers of a type of white blood cell)
- dizziness
- dyspepsia (heartburn)
- leukopenia (low numbers of a type of white blood cell)
- thrombocytopenia (low numbers of platelets)
Lynparza is also associated with other common or serious side effects and warnings. Review the product labeling to learn more and speak with your health care provider before treatment begins.
Learn more: Drugs.com Lynparza Patient Information
This is not all the information you need to know about Lynparza (olaparib) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Lynparza information here, and discuss this information and any questions you have with your doctor or other health care provider.
- Tutt ANJ, et al. Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer. N Engl J Med 2021;384:2394-2405.
- Lynparza (olaparib) product information. AstraZeneca. Wilmington, DE. Accessed July 15, 2022 at https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/00997c3f-5912-486f-a7db-930b4639cd51/00997c3f-5912-486f-a7db-930b4639cd51_viewable_rendition__v.pdf
- Lynparza.com. AstraZenenca. Accessed July 15, 2022 at https://www.lynparza.com/
- Lynparza.com. AstraZenenca. Accessed July 15, 2022 at https://www.lynparzabc.com/
Related medical questions
- How long does it take Lynparza to work?
- Does Lynparza cause hair loss?
- What type of prostate cancer is Erleada used to treat?
- What type of cancer is Rubraca used to treat?
Drug information
Related support groups
- Olaparib (3 questions, 3 members)
- Lynparza (3 questions, 6 members)
- Prostate Cancer (48 questions, 145 members)
- Breast Cancer, Metastatic (47 questions, 70 members)
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Rashida Williamson - Miss Black Metro Atlanta, USA 2018-2019
Posted By: Rashida Williamson on September 08, 2018
Miss Black Metro Atlanta, USA 2018, Rashida Williamson, is a Public Policy Analysis major with a concentration in Social Policy at Georgia State University- Andrew Young School of Policy Studies. A **** laude graduate and Deans' Academic Excellence Scholar, she earned a Bachelor of Arts in Political Science with a minor in History in the School of Arts and Sciences at Clark Atlanta University (CAU), Georgia. She is an alumna of the Isabella T. Jenkins, Ph.D., (ITJ) Honors and Scholars program.
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Sexual problems associated with infertility, pregnancy, and ageingBMJ 1999; 318 doi: https://doi.org/10.1136/bmj.318.7183.587 (Published 27 February 1999) Cite this as: BMJ 1999;318:587
- Jane Read
Infertility may interact with a couple's or individual's sexuality and sexual expression in two main ways. Sexual problems may be caused or exacerbated by the diagnosis, investigation, and management of infertility (or subfertility), or they may be a contributory factor in childlessness. Any examination of a couple's difficulty in conceiving must include overt and clear questioning about their sexual activity.
Responses to infertility
In response to being unable to conceive, many people feel emotions such as anger, panic, despair, and grief, and these may have several effects on sexual activity. The stress of infertility and its treatment may be a cause of sexual difficulties for both the prospective father and mother.
Intercourse may be avoided, with patterns of behaviour established, so that one or other partner is not reminded of the fertility problem. Postcoital tests or having to provide semen samples may result in a man feeling under pressure to perform, adversely affecting his erectile or ejaculatory ability. For some men, one or two failures during intercourse begins a vicious circle of fear of failure, with anxiety leading to further failures. Partners may also develop arousal difficulties because of anxiety or distress. Some individuals feel that their partner seems to want them only when there is a chance of conception, and sexual activity can then become a battleground for issues of power and control.
Useful questions to elicit information
How have your fertility problems affected your relationship, including your sexual relationship?
Has anything changed in your sexual relationship since you have been trying to conceive?
How would you describe your sexual activity?
How often do you have penetrative (that is, penis in vagina) sex?
Taken from Read J. Counselling for fertility problems. London: Sage, 1995:104
These stresses all conspire to alienate the couple from the recreational aspects of sexual expression and focus them, sometimes obsessively, on the procreative aspect of sexual intercourse.
Sexual problems commonly associated with infertility
Male problems
Loss of desire, with a consequent decrease in sexual activity
Erectile problems
Premature ejaculation—little or no control over ejaculatory response, and ejaculation may occur before vaginal entry achieved
Retarded ejaculation—difficulty ejaculating intravaginally, or at all
Female problems
Loss of desire
Sexual problems that result in infertility
Childlessness may be the result of an existing sexual dysfunction. One study of infertile couples found that 5% had a history of sexual problems.
To avoid wasting time and resources, it is important that patients are given the opportunity to discuss their previous pattern of sexual functioning, to see if it has changed in the light of their fertility problems. It seems inexcusable that people can undergo months or years of invasive and expensive treatment when simple, clear questions about their sexual lives may elicit information that could spare them the ordeal. Infertility examinations should therefore include an evaluation of couples' sexual behaviour, with special reference to frequency and timing of coitus.
Two further categories of sexual dysfunction need to be borne in mind. The first is retrograde ejaculation, in which, at orgasm, the ejaculate is expelled back into the bladder rather than externally. This can be checked fairly simply by examining a postejaculatory urine sample for the presence of sperm. Men with this condition experience "dry" orgasm, feeling the sensation of muscular action and orgasm but not producing an ejaculate. This is a fairly common presentation in fertility units and can be managed medically by centrifugation of the urine to collect the sperm.
The second point to consider is whether the sperm are being introduced into the vagina. This can mean talking in very clear terms to the couple about the nature of their sexual activity. Some couples engage in anal intercourse, in umbilical sex, or in manual stimulation alone and somewhat naively consider that their sexual behaviour is normal and should be resulting in pregnancy.
Physical factors associated with pregnancy that can reduce sexual activity
Pelvic vasocongestion
Vaginal congestion with reduced lubrication
Subluxation of pubic symphysis and sacroiliac joints
Retroverted uterus, particularly in first weeks of pregnancy
Weight of partner on uterus during intercourse in late pregnancy
Deep engagement of fetal head
Candida and trichomonas infections
Urinary tract infections
Stress incontinence
Vulval varicose veins
Data from Reamy KJ, White SE. Dyspareunia in pregnancy. J Psychosom Obstet Gynaecol 1985;4:263
Sexual difficulties in pregnancy
Pregnancy is a transition from one physical state to another. In the case of a first pregnancy it is a transition from one state of being to another—from being a couple to being a family, from being a person in relationship with another to motherhood or fatherhood. As with any transition, there is a sense of loss as well as excitement at entering another phase of life's experience.
It is important to remember that pregnancy is not always met with joy and that, even if a baby is planned and wanted, there may be some ambivalence: "Neither pregnancy nor its absence is inherently desirable. The occurrence of a pregnancy can be met with joy or despair, and its absence can be a cause of relief or anguish. Whether these states are wanted, the conscious or unconscious meanings attached to pregnancy and infertility, the responses of others, the perceived implications of these states, and expectations for the future all are critical factors in determining an individual's response."1
Included in this response will be myths about pregnancy, taboos about sexual activity during pregnancy, fears about the baby and delivery, changes in the relationship with the partner, and beliefs about the roles of motherhood and fatherhood. The woman's changing body shape may cause distress and a sense of unattractiveness.
This ambivalence may become manifest in sexual difficulties that are essentially psychological in origin, as an emotional response to the changed or changing state, or they may be a direct physical response to the pregnancy. One, of course, does not exclude the other, and a mixed aetiology is common.2 There may be a combination of sexual problems, and they may also occur in the period after delivery. A careful history should be taken to ascertain what is causing any difficulties.
Psychological factors
In cases when pregnancy is the result of infertility treatment or when there is a history of repeated miscarriages, fetal handicap, or neonatal death there may be high levels of anxiety, with repeated requests for reassurance or perhaps demands for scans or examinations. Apart from general anxiety, there may be specific concerns about body image, delivery, motherhood, changes to the couple's relationship, miscarriage, lack of self esteem, sexual guilt, and tiredness.
Points to consider when taking a history
Assessment of relationship, sexually and otherwise, and the support network
Whether the pregnancy was planned
Previous pregnancies and outcomes (such as miscarriage, termination)
Previous deliveries—type and presence of trauma
Current children's health
Contraception—past and current use and plans for the future
Sexual problems during or after pregnancy
Female problems
Loss of libido associated with tiredness, negative body image, etc
Anorgasmia associated with lack of arousal or pain
Vaginismus associated with pain or trauma from delivery
Female problems
Lack of desire
Erectile dysfunction associated with fears raised by watching the delivery, causing pain on intercourse, fatherhood
Premature ejaculation associated with fears raised by watching the delivery, causing pain on intercourse, fatherhood
Myths about intercourse during pregnancy include the fear it may cause miscarriage, premature labour, or fetal damage. Savage and Reader confirmed that there is no significant increase in fetal problems in women who continue to be sexually active throughout pregnancy.3 They noted that 27% of these women had uterine contractions after orgasm that were sometimes painful. Those who experienced painful contractions were less likely to have sexual intercourse often or at all.
There are, however, obvious indications for abstaining from intercourse during pregnancy,4 which include
Vaginal bleeding
Placenta praevia
Premature dilatation of the cervix
Rupture of the membranes
History of premature delivery
Multiple pregnancy.
Sexuality and ageing
Bancroft reported that there has been a widespread tendency to assume that elderly people are too old for sex activity and the sexuality of both men and women declines with advancing years.5 This decline depends on three main factors: the level of sexual activity throughout a person's lifetime, physical health, and psychological health.
Sexuality throughout life
People who have been sexually active on a frequent basis throughout their life will show a lower rate of decline in activity with advancing years than will those who have been less sexually active. Most elderly people who remain sexually active experience high enjoyment from sex,6 and, in a summary of studies on sex and ageing, Kaplan concluded that most physically healthy men and women remain sexually active on a regular basis into their ninth decade.7
What form this sexual activity takes could include solo and mutual masturbation, oral sex, and penetrative intercourse. It is essential to remember that elderly people may have just as wide a range of interests and preferences as younger people.
Physical health
Any condition or illness can have an impact on sexual function. For example, a woman with severe arthritis may have difficulties with using her hands to pleasure herself or her partner or finding a sexual position that minimises the pain. Careful positioning of pillows may help with the latter problem.
Patients may find it very difficult to raise subjects such as managing incontinence in sexual contact with another person and in solo masturbation, and it requires great sensitivity by the doctor to uncover such concerns. The use of appropriate creams to help with vaginal soreness—such as oestrogen cream (if the woman is not already taking hormone replacement therapy), KY Jelly or Senselle, or an aromatic oil such as sweet almond or peach kernel oil—may enable a woman (and her partner) to enjoy sexual activity much more fully. Giving patients "permission" to use vibrators to assist with access to genital areas and stimulation is often helpful.
Psychological health
Myths and beliefs about sexual attractiveness and what it is may affect older women and contribute to low self esteem and possibly depression. A woman who has been widowed may find difficulty in finding a new partner because of the higher ratio of women to men in older age groups.
Further reading
Read J.Counselling for fertility problems. London: Sage, 1995
Reamy KJ, White SE. Dyspareunia in pregnancy. J Psychosom Obstet Gynaecol 1985;4:263
Elderly people may be embarrassed or ashamed of having sexual needs "at their age," and they may feel fear and guilt about indulging in sexual behaviour after having been in a long term relationship, in effect a form of performance anxiety. For women especially, there may also be family expectations of celibacy that may be difficult to counter and other social expectations that elderly people are no longer sexual.
The photograph of a Shiva lingam is reproduced with permission of the Hutchinson Library. The cartoon "I've changed my mind" is reproduced with permission of Jacky Fleming from Be a Bloody Train Driver. The painting by Bonnat is reproduced with permission of Lauros-Giraudon and the Bridgeman Art Library.
Jane Read is a sex and relationship therapist in London.
The ABC of sexual health is edited by John Tomlinson, physician at the Men's Health Clinic, Winchester and London Bridge Hospital, and formerly general practitioner in Alton and honorary senior lecturer in primary care at the University of Southampton.
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