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Meat is an important food item for human nutrition( Reference Pereira and Vicente 1 ); however, excessive meat intake, especially red and processed meat, has been linked to chronic diseases( Reference Daniel, Cross and Koebnick 2 ) such as CVD( Reference Micha, Wallace and Mozaffarian 3 ) and cancer( 4 ). According to a recent systematic review and a meta-analysis, involving more than one million people, the intake of 50 g/d of processed meat increases the risk of CVD by 42 %, and of diabetes by 19 %( Reference Micha, Wallace and Mozaffarian 3 ). Another meta-analysis( Reference Aune, Chan and Vieira 5 ) has reported that the intake of 110 g/d of red meat is associated with a 27 % increased risk of colorectal cancer, and the intake of 50 g/d of processed meat is associated with a 29 % increased risk of colorectal cancer. Other studies have reported an association between red and processed meat intake and risk of cancer of the stomach( Reference Zhu, Yang and Zhang 6 ), oesophagus( Reference Choi, Song and Song 7 , Reference Salehi, Moradi-Lakeh and Salehi 8 ), lungs( Reference Yang, Wong and Vogtmann 9 )and other organs.
There are some reasons for meat to be linked to the risk of chronic diseases, such as heterocyclic amines (HCA) that are potentially carcinogenic substances, formed during the cooking process of meat (baking, frying and barbequing)( Reference Micha, Wallace and Mozaffarian 3 , Reference Jägerstad and Skog 10 ), besides high saturated fat content, high cholesterol content, Na and nitrites that are added to processed meat.
During HCA metabolism, reactive species are formed, especially by cytochrome P450, which can cause oxidation of lipids, proteins and nucleic acids, resulting in oxidative stress, cell damage and loss of biological function, thus increasing the risk of CVD and cancer( 4 , Reference Santarelli, Pierre and Corpet 11 – Reference Hu, La Vecchia and Morrison 13 ).
The levels of HCA formed are highly dependent on the type of meat cooked, the method, the temperature and the duration of cooking( Reference Knize, Dolbeare and Carroll 14 , Reference Skog, Steineck and Augustsson 15 ), ranging from 1 to 80 ng/g of meat for PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), the most abundant HCA in the human diet, followed by MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline) with usual amounts up to 6 ng/g of meat and DiMeIQx (2-amino-3,4,8-dimethylimidazo[4,5-f]quinoxaline) with amounts up to 1 ng/g of meat( Reference Rohrmann, Zoller and Hermann 16 ).
Despite the proven genotoxicity in various organisms, such as bacteria, Drosophila, cells in vitro and experimental rodents in vivo, the data are inconsistent in humans because it is difficult to identify the specific cell damage caused by HCA metabolism, and to estimate HCA intake( Reference Jägerstad and Skog 10 , Reference Gunter, Probst-Hensch and Cortessis 17 – Reference Ollberding, Wilkens and Henderson 19 ).
The aim of the present study was to investigate the association between HCA intake and oxidative stress, and the association between meat intake and oxidative stress.
Experimental methods
Study population and data collection
Data were obtained from a representative, complex, multistage probability-based cross-sectional study titled the Health Survey for Sao Paulo (ISA-Capital) conducted in Sao Paulo, Brazil, in 2008 and 2009. This survey collected information on health, food intake and lifestyle factors of the population of Sao Paulo city, an important financial and commercial centre in Latin America, and the most populous city in Brazil with approximately eleven million inhabitants in 2008.
A two-stage cluster sampling was used: census tracts and household. In the first stage, the census tracts were drawn using the probability of the number of households. In the second stage, the households were drawn using an inverse probability of the number of households. The drawing was systematic, and six study domains were defined by age groups and sex: females and males aged 13–19 years old (adolescents), 20–59 years old (adults) and 60 years old or over (elderly). It was estimated that a minimum sample size of 300 in each of the six domains was needed based on a prevalence of 0·5 with a standard error of 0·07 at a 5 % significance level and a design effect of 1·5. A total of 2691 individuals were selected to answer questions about life conditions and sociodemographic information.
After 1 year, a new contact was attempted with the same number of participants (n 2691) to new data collection (dietetic, biochemical, anthropometrical and sociodemographic information). After three tentative visits, made at different times (during weekdays and weekends), and six tentative telephone contacts, 62 % of the initial sample (1662 individuals) agreed to participate. Of those, 750 subjects (adolescents, adults and elderly) donated a blood sample. For the present study, only adults and elderly (n 561) were included.
Although the proportion of individuals who completed the study was similar by census tract and sociodemographic characteristics compared with the original sample, sampling weights were recalculated for each individual considering the sample design, non-response and post-stratification adjustment for sex and age group, in order to equalise the sociodemographic features of the sample. The School of Public Health of the University of São Paulo Ethics Committee approved the project. An informed consent form was obtained from all the participants.
Assessment of dietary intake
For the present study, dietary intake was estimated by one 24-h dietary recall (24HR). It was collected over 1 year covering all weekdays, weekends and seasons( Reference Thompson and Byers 20 ), administered by telephone using the Automated Multiple-Pass Method( Reference Dwyer, Picciano and Raiten 21 ). The telephone calls were made to the participant's home or their mobile phone. This method is structured in five steps: (1) quick list, where participants list all the foods and beverages consumed uninterruptedly; (2) forgotten list, where participants are asked about commonly forgotten foods consumed, such as candies, coffees and sodas; (3) time and location of food and beverage intake; (4) detailing cycle, where the way of preparation and amounts consumed are described; (5) final review, that verifies whether a certain food consumed during the day was not previously recorded( Reference Dwyer, Picciano and Raiten 21 , Reference Raper, Perloff and Ingwersen 22 ).
The household measures reported in 24HR were converted into g and ml according to standard Brazilian references, which measured many foods using a precision balance( Reference Pinheiro, Lacerda and Benzecry 23 , Reference Fisberg and Villar 24 ). Recipes were broken down into ingredients in order to estimate the amount of meat in each preparation.
Data from the 24HR were entered into the Nutrition Data System for Research – NDSR (version 5.0, 2007, Nutrition Coordinating Center at the University of Minnesota, Minneapolis, MN, USA)( 25 ), and were converted into energy and nutrients. The American database for the nutrition facts (energy, protein, carbohydrate and lipid) from the NDSR and the Brazilian nutrition facts database were compared. Only the foods from the NDSR that were similar (between 0·8 until 1·2 times) to Brazilian nutrition facts in terms of energy and macronutrients were considered.
Additionally, a detailed FFQ, based on the FFQ developed and validated by Cantwell et al. ( Reference Cantwell, Mittl and Curtin 26 ), was administered to each participant, containing information regarding the frequency of consumption of each food item, meat cooking preference (pan-fried, grilled, boiled, baked and microwaved) and level of meat doneness preference (medium, well done, and very well done for poultry and pork, and rare, medium, well done, and very well done for beef).
The amount of meat intake was estimated by the 24HR. The preferences of cooking methods and degrees of cooking, collected in the FFQ, were inputted in the 24HR to estimate the intake of HCA. These data were linked to the Computerized Heterocyclic Amines Resource for Research in Epidemiology of Disease (CHARRED) database to estimate the values of three HCA (PhIP, MeIQx and DiMeIQx).
Biochemical marker
Blood samples were obtained by venepuncture after a 12-h overnight fast by a nursing assistant. They were kept in a polystyrene box with ice packs, and transported to the laboratory for immediate centrifugation for 15 min at room temperature. After centrifugation, plasma samples were aliquoted and frozen at − 80°C until analysis.
The concentration of malondialdehyde (MDA) in the plasma was determined after derivatisation with thiobarbituric acid and quantification by HPLC/diode array, as described by Bastos et al. ( Reference Bastos, Loureiro and Oliveira 27 )and Hong et al. ( Reference Hong, Yeh and Chang 28 ). Internal tests revealed within-assay CV around 5 %, and between-assay CV around 16 %. The participants were divided into two groups based on the median of MDA concentration. The variable MDA was normally distributed, as determined by the Kolmogorov–Smirnov test.
Anthropometric measures
A trained research nurse measured body weight and height, using a standardised protocol. BMI was calculated as weight (in kg) divided by the square of height (in m). Nutritional status was determined based on BMI, using the cut-off points proposed by the WHO( 29 ) for adults and by Lipschitz( Reference Lipschitz 30 ) for the elderly.
Statistical analyses
Multivariate logistic regression models were estimated to verify the associations between the dependent variable (MDA concentration) and the following independent variables: meat intake (continuous variable); HCA intake (continuous variable); PhIP intake (continuous variable); MeqIQx intake (continuous variable); DiMeqIQx intake (continuous variable). The first model was a crude model (without co-variables); the second model was adjusted for age (continuous variable) and sex (female and male); the third model was further adjusted for energy intake (continuous variable), smoking (yes, no), BMI (healthy, overweight), skin colour (white, non-white), fruit and vegetable intake (continuous variable) and physical activity (active or not). OR and 95 % CI were estimated.
In the stratified analysis, mean and 95 % CI of MDA concentration were estimated according to the cooking methods and doneness levels for each kind of meat studied.
Differences between means were analysed using the Wald test, which calculates point estimates using F-statistics and considers the weights from complex samples. For categorical variables, the χ2 test was performed to compare the distribution of demographic characteristics. All analyses were conducted using the appropriate sample weights to account for the complex survey design. For all analyses, STATA® statistical software package version 10 (Stata Corporation) was used, and P< 0·05 was considered statistically significant.
The sample comprised 39 % men and 61 % women; 52 % adults and 48 % elderly. The means and standard error of food intake and sociodemographic information are presented in Table 1. Participants were divided into two groups based on the median of MDA concentration.
MDA, malondialdehyde; HCA, heterocyclic amines; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; DiMeIQx, 2-amino-3,4,8-dimethylimidazo[4,5-f]quinoxaline.
* χ2 for categorical variables; Wald-test for continuous variables.
The median MDA concentration was 0·71 μmol/l (25th percentile 0·49 μmol/l; 75th percentile 0·92 μmol/l), and it was not different between sex, smoking, skin colour and physical activity. Participants, who presented a MDA concentration above the median, consumed more HCA and PhIP than the below median participants. The same was not observed with DiMeIQx, MeIQx and meat intake (Table 1).
PhIP was the most consumed HCA, and beef was the most consumed meat (Table 1). 'Well done' was the doneness most cited among all varieties of meat, and pan-fried was the cooking method most mentioned. Beef contributed more to HCA amounts, followed by poultry and then pork (Table 2).
MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; DiMeIQx, 2-amino-3,4,8-dimethylimidazo[4,5-f]quinoxaline.
* No one reported meat intake in the specific cooking method.
Participants who consumed grilled beef very well done presented more MDA concentration than other participants (Table 3).
* Less than two participants reported meat intake in the specific cooking method and doneness level.
Table 4 shows the multivariate-adjusted OR for MDA >0·71 μmol/l by total meat intake and types of HCA intake. Positive and significant relationships between total HCA intake and MDA, as PhIP intake and MDA (P< 0·05), were observed. They remained significant after adjustment for smoking, sex, age, BMI, skin colour, energy, fruit and vegetable intake, and physical activity. However, MeIQx, DiMeIQx and meat intake were not significantly associated with MDA concentration.
PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; DiMeIQx, 2-amino-3,4,8-dimethylimidazo[4,5-f]quinoxaline.
* Model 1: Crude model.
† Model 2: Adjusted for age and sex.
‡ Model 3: Adjusted for age, sex, smoking, BMI, energy intake, fruit and vegetable intake, skin colour and physical activity.
The present study reported positive relationships between MDA concentration and HCA and PhIP intake in a population-based study. It showed that MDA concentration in the plasma can be increased by an intake of high total HCA and PhIP from meat, even after adjustment for sex, age, skin colour, physical activity, and intake of fruit, vegetable and energy, which can increase the risk of CVD and cancer.
Many studies( 31 – Reference Li, Li and Xie 33 ) have shown that HCA, especially PhIP, can produce reactive species and induce lipid peroxidation in vitro. A recent study has shown the relationship between PhIP intake and increased oxidative stress assessed by lipid peroxidation and protein oxidation in rats( Reference Li, Tian and Li 34 ). Other studies have reported that oxidative stress increases the risk of chronic diseases( Reference Stocker and Keaney 35 , Reference Dalle-Donne, Rossi and Colombo 36 ).
A hypothesis to explain that relationship between HCA and MDA is the biotransformation of HCA, which is a complex process to facilitate the excretion of these molecules. However, during the metabolism, unstable products (reactive species) can be formed( Reference Maeda, Sawa and Yubisui 32 , Reference Felton and Malfatti 37 , Reference Turesky and Le Marchand 38 ). These reactive species have important biological functions, such as gene activation and participation in defence mechanisms; nevertheless, when overproduced, they may favour the oxidation of lipids, proteins and nucleic acids, resulting in oxidative stress, cell damage and loss of biological function( Reference Barbosa, Costa and Alfenas 39 ), increasing the risk of chronic diseases( Reference Kryston, Georgiev and Pissis 40 , Reference Vassalle, Bianchi and Bianchi 41 ). MDA is the most used biomarker of lipid peroxidation, and its levels have been positively related to cancer and CVD( Reference Kryston, Georgiev and Pissis 40 , Reference Vasconcelos, Goulart and Moura 42 , Reference Perse 43 ).
The amount of HCA intake is variable worldwide. HCA intake was lower in the EPIC (European Prospective Investigation into Cancer and Nutrition) study( Reference Rohrmann, Zoller and Hermann 16 ) (69 ng/d) and in Sweden( Reference Augustsson, Skog and Jagerstad 44 ) (160 ng/d) than in Brazil. In the USA, more than 25 000 people consumed a mean of 455 ng/d( Reference Bogen and Keating 45 ), similar to that found in the present study.
Brazilians, in particular, are widely exposed to these compounds because overcooked meat is a very popular food item( Reference de Carvalho, César and Fisberg 46 ). In Sao Paulo, meat intake is excessive; more than 70 % of people consume above the national and international meat recommendations( Reference de Carvalho, César and Fisberg 46 , Reference Carvalho, Cesar and Fisberg 47 ). However, meat intake was not significantly associated with oxidative stress in the present study.
We reported that participants who consumed grilled beef very well done had a higher MDA concentration than other participants, evidencing that intake of very well done grilled beef may have contributed to increase oxidative stress when compared with other doneness levels. This suggests that intake of beef prepared as above could increase the exposure to a potentially harmful component of diet, supporting previous findings relating the intake of red meat cooked at high temperature to colon cancer( 48 , Reference Sinha, Peters and Cross 49 ).
An important consideration is that there are many sources of oxidative stress, such as smoking, radiation exposure, medication use, mitochondrial respiratory chain function, food intake and physical activity, in addition to HCA intake. For this reason, we adjusted regression models for other variables that could also contribute to increased oxidative stress.
HCA and PhIP intakes were reported to induce damage to other biological molecules, such as nucleic acids and proteins, leading to genetic damage and abnormal cell proliferation that may result in cancer( Reference Li, Tian and Li 34 , Reference Schraufstätter, Hyslop and Jackson 50 , Reference Lin, Kaderlik and Turesky 51 ). Further studies exploring HCA intake and other early damage biomarkers, such as DNA adducts, are needed.
The present study showed that high intake of HCA and PhIP may contribute to increase oxidative stress independently of lifestyle factors, increasing the risk of chronic diseases, such as cancer and CVD.
The authors thank the São Paulo Research Foundation (FAPESP – procedural 2009/15831-0, 2012/10965-0) and the National Council of Technological and Scientific Development (CNPq – procedural 481176/2008-0) for their financial support.
The scholarships were offered by São Paulo Research Foundation (FAPESP – procedural 2011/16225-6; 2012/10965-0; 2014/04607-0).
The authors declare that there is no conflict of interest.
The authors' contributions are as follows: A. M. C. carried out the study, biochemical analysis, data analyses, and drafted and wrote the manuscript; A. M. M. participated in the data analyses and drafted and wrote the manuscript; F. A. S. participated in the biochemical analysis and wrote the manuscript; A. P. M. L. participated in the biochemical analysis and drafted the manuscript; R. M. F. conceived the study, and participated in its design, coordination and drafted the manuscript; D. M. M. conceived the study, and participated in its design, coordination and helped to draft the manuscript.


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[ad_1] South Dakota Gov. Kristi Noem on Tuesday announced that her state is sending dozens of National Guard troops to Texas to
[ad_1] HUDSON, S.D. — A 10-year-old boy who died in the Big Sioux River saved one of his younger siblings who had
[ad_1] Adult film star Dakota Skye was discovered dead in Los Angeles, a family member confirmed. Skye, whose real name was Lauren
[ad_1] A 14-year-old North Dakota girl who was skateboarding at a strip mall was killed in a random attack lasting about 20
[ad_1] An 11-year-old girl in South Dakota recently caught a largemouth bass that could break the state record, according to a recent
[ad_1] South Dakota Gov. Kristi Noem promised to appeal a court ruling Wednesday that upheld the Biden administration's decision to cancel Fourth
[ad_1] There are more twists to this FCS championship game than just being played in mid-May to wrap up a unique spring
[ad_1] A North Dakota middle school student was stabbed at about 4:30 p.m. Tuesday outside of West Elementary School Grand Forks, in the
[ad_1] A high school rodeo club in the tiny South Dakota town of Faith has finally decided to end its annual "Slave/Branding
North Dakota Gov. Burgum vetoes transgender sports ban, following similar veto by South Dakota's Noem
[ad_1] North Dakota Gov. Doug Burgum on Wednesday vetoed a bill that would ban transgender girls from playing in girls high school sports following a

subset: commoncrawl


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NRL 2022: Cameron Munster stars as Storm win 32-14 over Titans, Jahrome Hughes injured
Cameron Munster's late switch to fullback proved a masterstroke for the Storm, but their premiership hopes have taken a hit with yet another star player injured.
Cameron Munster has produced a breathtaking display as Melbourne Storm marked a history-making night with a 32-14 win over gutsy cellar-dweller Gold Coast Titans at AAMI Park on Friday night.
The Storm's Bromwich brothers, captain Jesse (290 games) and fellow forward Kenny (211), became the first pair of brothers in NRL history to combine for 500 games (501) with the one club.
Kenny produced a first half try to make it the perfect start to the night.
But it was hat-trick hero Munster who kickstarted the Storm surge with two first-half tries before adding a third in the second half on a night of brilliance.
Stream every game of every round of the 2022 NRL Telstra Premiership Season Live & Ad-Break Free During Play on Kayo. New to Kayo? Start your free trial now >
Returning to the full back position where he started his career, Munster was safe at the back, dazzled with the extra room to move to rack up 252 run metres and offered tremendous leadership with his voice.
Winger David Nofoaluma, loaned from the Wests Tigers, showed off his speed and elusiveness in an impressive first start with the Storm, while centre Young Tonumaipea scored a try in his first game for the Storm since 2018.
Hooker Harry Grant and five-eighth Cooper Johns were also influential for the Storm.
The Storm made a barnstorming start with three tries in the opening 22 minutes.
Xavier Coates, returning from a long term injury, scored one of the easier tries of his career after Grant flicked out a quick pass to find him unattended in the corner.
Munster rose into the night sky to catch, spin and make his way across the line, before Kenny Bromwich got his try burrowing under Titans defenders Phillip Sami and David Fifita.
While the Storm led by 12 at the half, there were some concerns for coach Craig Bellamy, including niggles to Jahrome Hughes, who copped a shoulder knock, and Coates, who came up holding an ankle.
Coates took his spot on the wing for the start of the second half, but Hughes' subluxed shoulder ruled him out of the game.
The Titans refused to go away at the start of the second half.
Ever-present Brimson produced a skilful grubber kick to connect Brian Kelly with a try.
Unfortunately for the Titans, the deficit remained beyond a converted try after Boyd fluffed his conversion.
Jahrome Hughes missed the 2nd half with a left shoulder injury. By video concern for possible instability episode (subluxation/dislocation) landing on outstretched arm. If scans confirm would be facing multiple weeks recovery. Is the same shoulder he dislocated in 2018. pic.twitter.com/f2qyvgThyc— NRL PHYSIO (@nrlphysio) August 5, 2022
It took a while for the Titans to steady when hooker Aaron Booth succumbed to a knee injury.
The 26-year-old had to be helped off the ground by the trainers against his former club after his leg collapsed while attempting to tackle Johns.
Sam McIntyre took over the dummy half role and he combined well with halves Tanah Boyd and AJ Brimson, who had big roles to play in consecutive Titans tries to Beau Fermor and Herman Ese'ese.
Just when the Titans looked as though they were working their way back into the contest, they conceded a relatively soft try to Munster.
Johns found Munster with plenty of room to work into and he needed no second invitation to give the Storm a 22-10.
Nasty left knee injury for Aaron Booth, contact caused knee to collapse in significantly. Brings concern for stretching/tearing of medial knee structures (MCL) & possibility of fracture due to contact. Damage to ACL canât be ruled out considering amount of medial force. ð¤for him pic.twitter.com/BDqeSwx6jA— NRL PHYSIO (@nrlphysio) August 5, 2022
More CoverageKent: Brandy is right to blame Storm for hip-drop farceImmortal wants hip drop offenders rubbed out for months
Munster made it a hat-trick of tries with 15 minutes to go to finally break the Titans spirit.
The Storm solidified their spot in the top four after making it eight consecutive wins and 12 out of the past 13 over the Titans.
Originally published as NRL 2022: Cameron Munster stars as Storm win 32-14 over Titans, Jahrome Hughes injured


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RCMP police officers in Saanich, British Columbia, 22-year-old twin brothers Matthew and Isaac Ohter as two armed bank robbers who were killed by police in a gun battle on Tuesday. I have identified Ronnie.
Six police officers were injured in a gun battle at the Bank of Montreal in Saanich, southern Vancouver Island late Tuesday morning .
Police also said Thursday that they had to dispose of theexplosive device on the vehicle associated with the suspect.
The Auchterlonie brothers (22) were from Duncan, British Columbia, in central Vancouver Island. Neither of the siblings had a criminal record, according to the RCMP. They were not known to the police before .
"There are still many questions and research efforts that need to be made to fully understand what happened and why," Cpl said. Alex Belbe at a press conference on Saturday.
"The motive behind the armed robbery and the subsequent exchange of gunshots with police has not yet been determined."
Tuesday's shooting investigation was conducted by the Vancouver Island Integrated Crime Unit. (VIIMCU) is taking the lead. At the same time, an investigation was initiated by the Independent Investigation Bureau, an independent investigation agency that investigates all police actions that cause death or serious harm.
Belbe said police had spoken to the family of the suspect who was cooperating in the investigation. According to Belbe, the coroner service identified the brothers on Friday.
Police are still looking for public tips on the suspect's car, a white 1992 Toyota Camry with two black racing stripes on the hood and roof. Said.
They are asking their siblings or anyone who has information about their car to contact the VII MCU at 250-380-6211.


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text: For now, the library will be referred to as the Fresno State Library, or the Library. Efforts to remove Madden's name from signage, websites and other locations on campus will begin as soon as possible. library_FSN Posted by: Bill Clark July 24, 2022 0 12 Views Print this Article 2022-07-24 Bill Clark


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Homes of Opportunity Inc can be found at Northline Rd 22795. The following is offered: Employment Services. The entry is present with us since Sep 7, 2010 and was last updated on Nov 12, 2013. In Taylor there are 5 other Employment Services. An overview can be found here.
Homes of Opportunity Inc is located at 22795 Northline Rd, Taylor, MI. This business specializes in Employment.


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Where other cities run, New Plymouth prefers to stroll. With a laid-back atmosphere, sunny climate, pristine parks, and an abundance of art galleries, a trip to New Plymouth offers plenty of delightful relaxation. Take a gentle coastal walk, admiring the views of the water sparkling under the persistent sun. Meanwhile, Mount Taranaki looms above, dwarfing the city and beckoning hikers to the trails of its national park. Enjoy high-quality local cuisine at any one of a number of fine restaurants located in New Plymouth's center, along with good shopping opportunities. To arrange what you want to do in New Plymouth, use our New Zealand trip planner.
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New Plymouth's waterfront offers the most pleasant accommodations in the city, with boutique hotels and welcoming bed and breakfasts, along with rental apartments. Also close to the water, RV parks provide an excellent choice for families and campers. Farther out of town, expect to find motels and campsites, conveniently accessed by car or local buses.
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Most drivers know that tire rotation needs to happen every so often, but how often should you rotate your tires, really? Generally, an interval of 5,000 to 7,500 miles is going to be most appropriate, however, there are certain factors that can affect that guideline. We've covered everything you need to know in order to keep your Land Rover at its best, below.
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text: Home > Business Bangko Sentral keeps benchmark rate unchanged to support growth ABS-CBN News Posted at Feb 17 2022 03:09 PM | Updated as of Feb 17 2022 04:00 PM Share Facebook Twitter LinkedIn Viber MANILA - The Bangko Sentral ng Pilipinas on Thursday kept the benchmark rate unchanged as inflation eases and as the economy continues to recover from the impact of the COVID-19 pandemic. The overnight reverse repurchase facility, which banks use to price loans, has been pegged at the historic low of 2 percent since November 2020, with the overnight deposit and lending facilities also kept at 1.5 percent and 2.5 percent, respectively. BSP Governor Benjamin Diokno earlier said the central bank is keen on keeping a balance between supporting recovery and managing inflation. "The Monetary Board deems it prudent to maintain the BSP's accommodative policy stance given a manageable inflation environment and emerging uncertainty surrounding domestic and global growth prospects," Diokno said. Inflation eased to 3 percent in January 2022 using 2018 as the base year. It hovered above the 2 to 4 percent target range in 2021, with the full average reaching 4.5 percent using 2012 as base year, data showed. Economic recovery continued to gain traction but the elevated global commodity prices, heightened political tensions and an uneven vaccination pace globally remain as risks, Diokno said during a virtual briefing. "Looking ahead, given the stronger signs of recovery in output growth and labor market conditions and improvements in domestic financial markets, the BSP will continue to carefully develop its plans for the eventual normalization of its extraordinary liquidity measures when conditions warrant, in keeping with our price and financial stability mandates," he added. BSP Gov. Benjamin Diokno says the Monetary Board decided to keep key interest rates unchanged at its first policy meeting for 2022. The PH benchmark interest rate has been at a record low of 2% since November 2020. pic.twitter.com/R1zqFmJtO7 — Warren de Guzman (@wddeguzman) February 17, 2022 BDO Unibank chief market strategist Jonas Ravelas said the BSP is likely to hike interest rates once by 25-basis points before December 2022 if inflation won't exceed 4.2 percent. Two rate hikes could be implemented if inflation accelerated more than that, he added. Ravelas said it would be critical to monitor several commodity prices that could affect inflation such as crude oil. Fitch Solutions, meanwhile, earlier said it expected the BSP to raise interest rates by up to 75-basis points in 2022. BSP likely to keep interest unchanged in Feb: analyst Several central banks globally have eased stimulus placed during the pandemic to address inflation. The US Federal Reserve is expected to implement 4 or 5 rate hikes this year, Ravelas said. But the BSP is willing to wait for the right conditions before unwinding stimulus, according to Diokno. BSP says waiting for right conditions to unwind stimulus BSP maintains interest rate at 2 percent The BSP's Department of Economic Research slightly raised its inflation outlook for 2022 to 3.7 percent from 3.4 percent and to 3.3 percent from 3.2 percent for 2023. RELATED VIDEO: Watch more News on iWantTFC Share Facebook Twitter LinkedIn Viber ANC, ANC Top, BSP, interest rate, inflation, Read More: BSP interest rate inflation commodity prices crude oil borrowing rate stimulus economy


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As a guest of Fisherman's Huts, you'll find a terrace, tour or ticket assistance, and a BBQ. Public spaces have free WiFi. Fisherman's Huts also features a garden and coffee/tea in common area. Free self parking is available. Smoking is allowed in designated areas at this Sikao hotel.
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Fisherman's Huts offers 8 air-conditioned accommodations with complimentary bottles of water and free toiletries. Rooms open to patios. Televisions come with satellite channels. Bathrooms include a shower. Guests can surf the web using complimentary wireless Internet access. Housekeeping is provided on a daily basis.
The recreational activities listed below are available either on-site or nearby; fees may apply.
Special check-in instructions:
The front desk is open daily from 8 AM - 5:30 PM. If you are planning to arrive after 5:30 PM, please contact the property in advance using the information on the booking confirmation. Front desk staff will greet guests on arrival.
The front desk at this property is open daily from 8 AM - 5:30 PM.
Guests arriving after 5:30 PM must make advance arrangements by contacting the property using the information on the booking confirmation. Front desk staff will greet guests on arrival.
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts cash
Be prepared: check the latest COVID-19 travel requirements and measures in place for this destination before you travel.
Charges for extra guests may apply and vary according to property policy.
A cash deposit for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
This property accepts cash.
The fees and deposits listed below will be charged at the time of service, check-in, or check-out.
This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.


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Great Falls
Things to do
Great Falls, MT Real Estate
If you're looking for a piece of real estate in Great Falls, you may be interested in finding that the city has a variety of houses, condominiums, land, and mobile homes for sale. In March 2022, there were 180 percent more properties for sale in Great Falls, Montana, than in February 2022. Listings remained on the market for 33 days in March 2022.
The average residence in Great Falls is worth $278,862, and this is a seasonally adjusted number that only covers residences in the medium price category. However, property values in Great Falls have increased by 24.2 percent in the last year. However, this magnificent metropolis boasts numerous natural wonders and compelling reasons to invest in real estate.
Affectionately called "The Electric City," Great Falls has a long history dating to the historic Lewis and Clark expedition in 1805. They toured the newly acquired Louisiana Territory, which was densely forested with herds of buffalo. The Great Falls area was long inhabited by indigenous American Indian groups, primarily the Blackfeet. Unlike other modern cities, Great Falls was developed by an exceptionally practical and smart individual. Gibson ensured that the roadways were built out in a precise, arrow-straight layout during the town's organization, and he earmarked 886 acres for city parks. However, the city's present culture evolved from its heritage, most notably via the life and legacy of western artist Charles M. Russell, the famed cowboy who settled in Great Falls.
Things to do in Great Falls
Things to do in Great Falls
Great Falls is a state in the United States. Located on the Missouri River in the heart of Montana, Helena serves as a basecamp for a wide range of outdoor excursions and serves as a haven for rich arts, culture, and history in a lively, modern community where an expansive, unspoiled, and diversified landscape renews one's spirit.
Witness The Great Falls of The Missouri River
This group of four waterfalls, located within Giant Springs State Park on the Missouri River, is the source of the city's name and a visually magnificent location to explore. Even though the environment has altered significantly since Lewis and Clark encountered these gigantic waterfalls in 1805 due to the construction of dams, the site is still as fascinating as ever.
The Great Falls over Ryan Dam, Crooked Falls, Rainbow Falls, and Black Eagle Falls are the four waterfalls that make up the area. The Black Eagle Falls are the nearest to town, while The Great Falls are the most impressive. Water cascades over the falls throughout the year, but the best time to see them at their most spectacular is in the spring.
CM Russell Museum
The CM Russell Museum is located in the city of Russell. It was founded in 1931 by C. M. Russell. Among the museum's principal responsibilities is the display of the artwork of Great Falls "cowboy artist" Charles Marion Russell, in honor of whom the institution is named. Other items on show at the museum include illustrated letters written by Russell, work supplies used by him, and other things that help visitors better understand Russell's life and working habits.
Lewis and Clark Heritage Trail
The Corps of Discovery observed, "the grandest sight" on June 13, 1805, when they became the first white men to encounter the Great Falls of the Missouri River, which they dubbed "the grandest sight" at the time. By virtue of the fabled expedition's legacy, you can now travel the fabled portage route in its entirety. As a result, the Great Falls Portage is a National Historic Landmark perfect for history fans, families, groups, and anyone interested in seeing the region as the Corps of Discovery did.
Giants Spring
This geologically significant spring is near Great Falls, Montana, and Giant Springs State Park encompasses the spring and serves as its focal point. Located 60 miles distant in the Little Belt Mountains, its water has a constant temperature of 54 degrees Fahrenheit and is sourced from snowmelt. According to chlorofluorocarbon dating, it takes approximately 26 years for the water to flow underground and then return to the surface at the springs to reach the surface. It's an excellent starting point for appreciating the natural wonder of Great Falls.
Experience The River's Edge Trail
The River's Edge Trail serves as the city's primary pedestrian thoroughfare and connects many neighborhoods. It runs along both banks of the Missouri River for 60 miles within the city limits, connecting natural areas, the historic downtown center, and several cultural destinations.
You should also visit the Great Falls Cemetery Trail, the Lewis and Clark Interpretation Center, and the Paris Gibson Square Museum of Art, which are worthwhile venues for your sightseeing and exploring trip.
Great Falls is a significant city in Montana near the Missouri River, and it is a popular tourist destination and a hub for leisure, research, and social life. Its Latitude and longitude coordinates are 47.506187, -111.283691, and 47.506187.
Great Falls demographics
Great Falls demographics
On January 1, 2019, the population of Great Falls, Montana, was 58,800 people aged 38.6 years and earning a family income of $46,965. During the period 2018-2019, the population of Great Falls, Montana decreased from 58,990 to 58,835, representing a 0.263 percent loss, while the median household income increased from $45,620 to $46,965, representing a 2.95 percent rise.
White (non-Hispanic) (84.3 percent), American Indian & Alaska Native (non-Hispanic) (4.93 percent), Two+ (non-Hispanic) (4.36 percent), White (Hispanic) (2.6 percent), and Other (Hispanic) (2.6 percent) are the five most populous ethnic groups in Great Falls, Montana (1.29 percent ). 0 percent of households in Great Falls, Montana, speak a language other than English at home as their primary language.
Meanwhile, 99.3 percent of the people who live in Great Falls, Montana, are citizens of the United States. 2.16 percent of Great Falls, Montana inhabitants (1.27k persons) were born abroad in the United States as of 2019, lower than the national average of 13.7 percent. Citizens born overseas in Great Falls, Montana, were 2.2 percent, indicating that the rate has declined throughout the years.
The typical property value in Great Falls, Montana, in 2019 was $176,500, while the homeownership rate was 62.6 percent, according to census data. The majority of people in Great Falls, Montana, commuted alone to work, with an average commute duration of 13.6 minutes every day. Meanwhile, each household owned an average of two automobiles.
Arts in Great Falls
Arts in Great Falls
Embedded in Great Falls' identity and community (thus the "art" in "Basecamp of Art and Adventure") is a strong commitment to the arts. A wide range of areas is covered by the city's cultural amenities, including music (in the form of laid-back performances or our own symphony), dance, theater, and every other artistic media you might desire. Also located in Great Falls is the C.M. Russell Museum, dubbed "The Art and Soul of the American West."
Performances in Person
When it comes to date nights in Great Falls, food and a movie aren't the only choices — far from it. The thrill of seeing your fellow community members perform on stage - whether live dance, the Great Falls Symphony, an open mic night, or a play at the theater – is unparalleled. You can enhance your cultural awareness by attending the numerous live performance opportunities in Great Falls: The Newberry, Celtic Cowboy Great Falls Municipal Band.
Art At Its Finest
Take a look at the expertly chosen galleries and museums. There are numerous options to consider (and all are must-visits). Although the studios and galleries in Great Falls showcase a diverse range of styles and eras of art, one could argue that we are most recognized for presenting American Western art. You'll be intrigued for hours by the excellently recorded and preserved exhibits in Great Falls, whether you're looking for a cultural yet educational experience for your children or a history buff yourself.
Schools in Great Falls
Schools in Great Falls
A few notable educational institutions in this city include The University of Great Falls, The Great Falls College, Montana School for the Deaf and the Blind, Montana State University, and several extensive public library systems. However, the University of Providence (which has awarded 399 degrees) and the Montana Academy of Salons (85 degrees) are also noteworthy.
Why Great Falls?
Why Great Falls?
With safe neighborhoods, good schools, an abundance of recreational possibilities, outstanding health-care facilities, and the gorgeous Montana landscape right outside your door, you've made the correct decision to live in Montana. Greater Great Falls, Montana's third-largest city with over 58,000 people, has a lot to offer its inhabitants, businesses, and visitors alike.
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After the events at Christ's birth, and her receiving a special message from the angel that her child would be the Son of God, it is absurd to say that Mary was taken by surprise. As for the brethren of Jesus, He had no brethren in the first degree. Any relatives, even in the third or fourth degree, or even in the same tribe, were entitled brethren by the Jews. And of course some of these were surprised, unless we are to suppose that God made a special revelation to each one of them concerning Christ The Jews generally were surprised because they had built up in themselves despite the prophecies so very different a concept of the coming of the Messiah.
Radio Replies Volume 1 by Rev. Dr. Leslie Rumble MSC and Rev. Charles Mortimer Carty


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TAMPA, Fla. (CW44 News At 10) – A new COVID-19 vaccination site specifically serving veterans is now open in Tampa.
Previously located near James A. Haley Veterans Hospital, the vaccination operations moved Tuesday to the Yuengling Center on the University of South Florida campus. Organizers say the previous site was much smaller and was causing a lot of traffic issues. At the new site, space is at a premium and will better assist with the current goal to vaccinate up to 1,500 people per day, eventually increasing to 3,500.READ MORE: Authorities Have Identified The Suspect Who Attacked Author Salman Rushdie
Navy Veteran Jatin Sharma says, "It's been taking forever, so getting this vaccination I think is really great." Tuesday was a day Sharma has been looking forward to for a long time. "Getting this done was important. I could have waited until whatever date but I think this was an important decision, not just for me but for my family."
After hearing a new vaccine site specifically for veterans was opening up in Tampa, he made the two-hour drive from Orlando. "The more facilities like this, the better it's going to be, the quicker it's going to be. It's just wonderful," said Sharma.READ MORE: Anne Heche's Son Mourns His Mother
Mara Carrasquillo, the veteran hospital's Chief of Pharmacy, says "Those are the people who did so much for all of us and we thank them for the service that they did, so veterans are our number one priority." Carrasquillo says moving the site from the James A. Haley Veterans Hospital to the Yuengling Center will eventually allow them to give up to 3,500 shots per day. "The goal for us to move here was to be able to do more. Why? Because we had limitations at the in the parking lot that we were at in terms of space," said Carrasquillo.
An added benefit of the site allows the vaccination of family and caregivers of veterans enrolled with the hospital. "We need to vaccinate as many people as we can so we can end this pandemic," said Carrasquillo.
Sharma says with one shot down, the second dose means a trip to see loved ones. "I haven't seen my mom and dad for over a year now so going back to New York, it will be great. My son he's five years old, so it means a lot. Talking on the phone means one thing but meeting them finally is another thing."MORE NEWS: Florida Students Return To Schools Reshaped By Gov. Ron DeSantis' Anti-'Woke' Education Agenda
The center is also offering vaccines to those who meet the state's requirements.