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Lughnasadh Ritual
Join us in person to celebrate Lughnasadh!
Lughnasadh—also called Lammas, or Loaf-mas—is the festival of the first bread, and with it, a celebration of the god Lugh. Lugh, god of the lightning strike; Lugh, the master of many tools; Lugh, the quick-tongued warrior who uses truth as one of His weapons; Lugh, the unlikely leader who knows the ins and outs of resisting an empire. In this season, we follow His lead, celebrating not only the gifts of the earth that sustain us, but also the sacrifices that allow us to survive.
The Green Man Store has hosted many Reclaiming LA rituals though the years, and this will be our first time circling there since Brigid 2020! We are looking forward to returning during the festival of Lugh, a long-term ally of Reclaiming LA. Join us as He invites us to remember our community bonds in these new times, and to honor our strength and our tenderness as we mark this turn in the wheel.
Ritual intention:
The story you tell is the spell you cast.
7:30 pm Doors Open
8:00 pm Ritual Start
The Green Man Store
5712 Lankershim Blvd
North Hollywood, CA 91601
(818) 985-2010
~Cash preferred.
~No one turned away for lack of funds.
Your entry fee allows us to support and continue to hold events at The Green Man, a small business that has served a wide community of LA witches for many years.
Reclaiming LA is committed to economic justice, and we recognize that this fee may pose a financial hardship for some of our community members. If you plan to attend the ritual and you are unable to pay the entry fee, we welcome you to email email@example.com, and we will add you to a list of those who will receive free entry to the ritual space. No questions will be asked, and there is no need to provide justification for your request.
The ritual will be held fully outdoors.
Please bring a mask. Celebrants will be asked to mask during parts of the ritual that involve close contact.
To ensure that vulnerable community members are protected from the ongoing pandemic, we will not hold an indoor potluck or Bardic circle.
Doors open as early as 7:30, and will be locked shortly after the ritual start time of 8PM.
All genders welcome!
Children welcome with adult supervision.
To support those in recovery, this ritual is drug and alcohol free.
The ritual space is on mostly even concrete in the open-air backyard of the store. Access to the ritual space is level and wide enough for wheelchair access. Typically, accessing the ritual space requires going through the store, which does have strong scents, and accommodations can be made in advance to come in through alleyway. The ritual space will have some light after dark, but it is minimal. Chairs are available for those needing to sit for part of or all of the ritual, and the ritual is structured to allow for participation also while seated.
Acoustics in the yard can be difficult with aircraft flying overhead; however, there are no constant loud noises, and the ritual is conducted with awareness of the ambient noise level to help with hearing. Very rarely, due to inclement weather (either heavy rain or wildfire smoke), the ritual is moved to an indoor space which is up a flight of stairs with no wheelchair access.
We have written this accessibility statement to be as inclusive as possible so that people with accessibility concerns do not have to do the labor of asking. If we have overlooked some aspect, please email us at email@example.com, and we will do our utmost to answer—your question will help us to improve our accessibility statements on future rituals.
2022 Ritual Calendar
Lughnasadh: Saturday, August 6 at The Green Man
Autumn Equinox: Saturday, September 17 at Griffith Park
Samhain: Saturday, November 5 at The Green Man
Yule: TBD at Nicholas Canyon Beach
Ritual plans may be subject to change based on local health guidelines and the needs of our community. For up-to-date information on upcoming rituals and events, subscribe to the Reclaiming LA mailing list!


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In the past 24 hours, 782 new Coronavirus cases have been reported – the highest since the outbreak began. Wahid Majrooh, Deputy Minister of Public Health, said the total number of infected people is almost at 9,998 with 216 dead and 1,000 recovered.
Officials at the Ministry of Health (MoPH) said Kabul with 377 new cases, has the highest number of infected people in the country, followed by Herat with 150 cases. The other provinces don't fare any better with 49 new cases registered in Balkh, 47 in Ghazni, 32 in Nangarhar, 28 in Paktia, 21 in Samangan and 12 in each of the provinces of Paktika, Baghlan and Logar.
Wahid Majrooh said the virus outbreak would continue to spread unchecked if the people do not comply with the quarantine, especially during the Eid Al-Fitr holiday.
"We strongly warn citizens that if they do not comply with quarantine, do not stay in their homes and do not follow the correct recommendations, both they and all members of their families will be infected with the virus," he said.


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Amanda Jean Mataya Pietig, OD is a health care provider primarily located in Ankeny, IA. She has 15 years of experience. Her specialties include Optometry.
Graduated in 2007
Dr. Mataya Pietig graduated from the Illinois College of Optometry in 2007. She works in Ankeny, IA and specializes in Optometry.


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UK hydrogen development action plan
Published on 20 July 2022, by the UK government, it follows on from the UK Hydrogen Strategy and the British Energy Security Strategy, the latter of which doubled the government's 2030 target for low carbon hydrogen production capacity to 10GW
German gas market supply status update report – 09 August
Gas flows from Nord Stream 1 are currently at about 20% of maximum capacity.The storage level at the Rehden facility is 49.79%. Companies and private consumers must expect a considerable increase in gas price…
Impact of a ban of fossil boilers on import dependency
A blanket ban of gas and oil boilers could slash EU's imports of Putin's gas by up to 28% according to the authors of this report….
The Pain of a Potential Russian gas shut-off to the European Union
Can access to the global liquefied natural gas (LNG) market help in buffering the economic impact of a Russian gas shut-off on Europe?
Natural gas price benchmarks – July 2022
Gimme more: European gas prices averaged at a record high of $50/mmbtu in July, amidst further supply cuts via Nord...
Nord Stream is back?
Nord Stream is coming back: first nomination data indicates that Nord Stream will restart flowing gas from tomorrow. A few caveats...
German gas storage injections turn negative
Why so negative? Germany's net storage injections moved into negative territory, with withdrawals outpacing injections. Nord Stream maintenance, combined with...
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Gluten Free Vanilla Cupcakes
Learn how to make the best gluten-free vanilla cupcakes with this quick and easy recipe!
8 hours ago - Food Gawker
Gluten-Free Muffins
This is the only Gluten-Free Muffin recipe you need! Leave the batter as is or add mix-ins like blueberries, chocolate chips or apple.
8 hours ago - Food Gawker
Gluten Free Peanut Butter Blondies
Blondies but with creamy peanut butter, dark chocolate chips, crushed peanuts and NO refined sugar! A peanut butter lovers dream!
15 hours ago - Food Gawker - 2 articles
Romesco Sauce Nut Free
Only 5 min to make easy roasted red pepper romesco sauce, nut free, gluten free. A versatile sauce perfect for fish, roasted veg, and more!
19 hours ago - Food Gawker
Green Beans With Almond
This green beans with almonds appetizer salad recipe is most deliciouos one. It's healthy, and full of protein and gluten-free.
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Gluten-Free Spice cake
A delicious and easy recipe for a classic homemade gluten-free and dairy-free spice cake with whipped cinnamon cream cheese frosting.
21 hours ago - Food Gawker
Healthy Gluten Free Blondies
Made with mashed bananas and oat flour, these delicious blondies are perfect with maple syrup or topped with yoghurt and fruit.
1 day ago - Food Gawker
Healthy Funfetti Pancakes
Healthy funfetti pancakes are vegan, gluten-free & a festive birthday breakfast! These birthday cake pancakes are made from scratch.
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Sun Dried Tomato Chicken Pasta
Creamy Sun Dried Tomato Pasta with Chicken is going to be your new repeat meal. It's hearty, creamy, and can easily be made gluten-free.
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Matcha mochi muffins
An easy matcha mochi muffin recipe that is naturally gluten-free. Requiring no mixer, its crisp exterior and soft gooey inside is delicious!
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The headlines of Food Drink Buzz
These zesty low carb cilantro lime salmon skewers are fun to grill, and easy to make on a skillet or a nonstick griddle.
Blueberry Chocolate Chip Muffins
These buttermilk blueberry chocolate chip muffins are perfectly moist and tender muffins loaded with chocolate chips and plump blueberries.
Creamy Chicken and Rice Soup
Creamy Chicken and Rice Soup is amazingly thick and luscious but made without any cream
Polish Sweet Cheese Pierogi
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Ensenada Fish Tacos
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This apple bread screams autumn with loads of chopped apples and warm spices like cinnamon, nutmeg, and allspice.
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Goat Cheese and Tomato Orzo
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Chopped Chicken Protein Salad
An easy and healthy chopped chicken protein salad you should be eating right now.


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Three Blankets To Consider For Your Newborn Photos
In many newborn photo shoots, it's common for the infant to be wrapped in a blanket. Some couples choose a standard blanket that is somewhat of an afterthought, but this isn't your only option. As you prepare for the photo shoot, think about what blankets have a special significance to you. There's a good chance that you can come up with a few different ideas. Gather the blankets and take them to the photo studio, and talk to your photographer about including each of them in the shots. The photographer can take a few shots of your child wrapped in one blanket, and you can then remove that blanket and wrap them in the next one. Here are three blankets to consider.
Handmade Blanket
When many people have babies, they'll often receive a handmade blanket from a family member. It might be a knitted or crocheted blanket from the child's grandparent, for example. This blanket will have a special significance to your family, so it's nice to include it in some of the newborn photos. When you receive the photos a short time after the shoot and are ready to share them with your family, you'll be especially excited to give the person who made the blanket a large print of your child wrapped in the homemade gift.
Sports Blanket
If you're a serious sports fan, there's a good chance that you have several sports-related accessories around the house. One item may be a blanket that features your favorite team's name and logo. It can be a fun idea to take this blanket to the photo shoot and wrap your infant in it for a few shots. There's a good chance that a lot of your family members and friends know about your support of a specific team, and they'll be amused to see your child wrapped in a corresponding blanket — serving as a sign that you'll do your best to raise the child to be a fan of the team, too.
Your Blanket
If you or your significant other still owns a blanket that you used as a child, it can be special to take it to the photo shoot. Some people have their baby blankets boxed away with other personal mementos from their childhood. Even if this blanket is in rough shape and not suitable for daily use with your child, it can be a special moment to secure your newborn in the blanket that wrapped you or your partner multiple decades ago.
For more information, contact a local company like Joanna Andres Photography.


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How to sell my car in Batley
Enter your car details for a quote
Simply use our website to enter your registration number and we'll be able to provide a quote from this. Once you've got this, you can call us to discuss the valuation in detail with you.
Alternatively, you can contact us on 01142 559 555 with the details of your vehicle and we can make an offer for your car over the phone.
We'll come to you & collect for FREE
Once you've received your quote and are happy with the price we've offered, we'll arrange a suitable time for us to view your vehicle. It is at this stage that we will make a firm and precise offer for your car. Our promise is to not waste your time, we will view your car with a view to purchasing it.
At this point, we can either take your car with us then or alternatively, arrange a suitable time to return and collect your car if you are needing it for a little longer. What's better, we do all of this for free!
"I recently sold my car to Abbeywood Motors and the whole experience couldn't have been easier. Great service, offered a decent price and money was transferred within minutes of the car being test driven. Overall, a great experience and I would definitely recommend this company."
We buy any car Batley
Looking to sell your car in Batley? Abbeywood Motors is a family-owned Yorkshire business that has operated across three generations. We're now in our 39th year of buying cars.
No matter where you're based in Batley or the surrounding area, we'll come to you and collect your car for free at a place of your choosing, ensuring a seamless car selling process.
Or if you'd like to come to us, our Sheffield city centre base is within easy reach of Batley and Yorkshire, just off the Sheffield Parkway and close to the M1.
Sell your car quickly
If you find yourself in the position of needing to sell your car quickly, for whatever reason, be assured that we have streamlined our process to ensure no time is wasted.
Once the price has been agreed for your car, we can take it immediately. However, if you need the car temporarily to get around, we will offer to come back at a later stage. At Abbeywood, we offer a fixed price, so you don't need to worry about re-negotiating when we call to collect the vehicle.
We know that selling your car can be a stressful process, but even more so if you're needing to do it quickly. Using our decades of experience has allowed us to ensure that we take as much stress as possible out of this situation for you, giving you a quick and efficient solution to selling your car quickly whilst being cared for by our friendly team every step of the way.
Payment Methods For Your Car
When you sell your car to Abbeywood, there are many methods that we can use to pay you for it:
Cleared Cheque
Bank Draft
Electronic Transfer
Once we have agreed upon a price to buy the vehicle, we will be happy to discuss this to find the most suitable option for you.
All of our pricing is transparent. We do not add on buyer's fee or transaction fees, the offer that we give you is what you can expect to receive.
We are proud of our quick and easy process for selling your car – there is no hassle, no worries and no outlay for yourself. If you're interested in selling your car in Batley, simply fill in the registration number or give our HQ a call!
Sell your car quickly in Batley
If you're looking to sell your car in Batley and want a quick, efficient and stress-free experience, then Abbeywood Motors are here to help. Simply click the button below, enter your vehicle details and we'll provide you with a quote. Alternatively, call us on 0114 255 9555 and we'll make an offer for your car over the phone.


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There are some serious things to consider when reaching a Colombian girl. Firstly, you must entertain serious motives towards her. Men should certainly mention that this individual has ideas to marry her in the future. Colombian women are known to be very religious and loyal. So , they will not want to have any kind of affair. Be sure you respect their father and mother and members of your family. A Colombian girl is very vulnerable to value loyalty most of all.
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As a person, you should be respecting her as well as her region. Colombian females value their own families and are not prone to assault. If you are willing to experience her parents, https://www.amazon.com/Little-Habits-Happy-Successful-Relationships/dp/059332773X it could be inappropriate to insult her parents or perhaps family members. They could not want to invest period with you away from home and may even receive angry in case you insult them. They also value the family, if you disrespect them, they will receive very angry and hurt.
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Dec 11, 2019 The primary difference between crushed stone and gravel is that gravel is not man-made. It forms naturally from large rocks, which erode over time, creating smaller rocks. As a result, crushed gravel is typically rounder and has a smoother shape than crushed stone. Gravel has less carrying capacity than the crushed stone.Read More
Here are some reasonable stone production line plans: 1. Vibrating feeder + jaw crusher + Multi-cylinder Hydraulic Cone crusher+ reshaping machine (VSI Crusher) + vibrating screen Main characters of this plan is that it adopts advanced multi-cylinder hydraulic cone crusher. This makes fine products to take a bigger proportion. 80% of the finals can be smaller than the size of discharge opening.Read More
There are 9 types of cone crushers and 6 types of impact crushers you can choose for primary crushing plant, which can satisfied all secondary crushing. whose final products are good shape. The maximum capacity of pure screening + grizzly bar hopper can be 400t/h, besides, A+t/h is the largest preparedness capacity of K series Secondary ...Read More
Terex Finlay Cone Crushers are renown for their capabilities in crushing mid-hard and above mid-hard ores and rocks. The Finlay range of cone crushers provide flexibility, high rates of productivity and excellent product shape in secondary and tertiary applications.Read More
Mar 08, 2021 1 The finished product is cubic, with good grain shape and low needle-like content; 2 Suitable for crushing of various hardness rocks such as limestone, basalt stone, granite, pebbles, coal, etc; 3 It is relatively convenient to maintain and operate compared with mobile stone crusher machines;Read More
List Of Secondary Jaw Crusher Manufacturer In India. Hydraulic cone crusher,cone crusher for sale,secondary , the hydraulic cone crusher is designed to feature a perfect combination of crushing speed,eccentricity and high quality crushing cavity the intergranular laminating crushing significantly improves yield and product shape as our most.Read More
Mar 08, 2021 Semi-fixed stone crusher is a transition from semi-mobile stone crusher station to fixed crusher station. From the perspective of the foundation, its crushing frame has a strong connection with the ground (the bedrock can be connected by anchor piles, and …Read More
Apr 27, 2021 Primary crushing with impact crushers. The primary impact crusher offers high capacity and is designed to accept large feed sizes. The primary impact crushers are used to process from 200 t/h up to 1900 t/h and feed sizes of up to 1830 mm (71 ) in the largest model.:::First published in the September 2014 issue of […]Read More
For secondary crushing, you can choose impact crusher, cone crusher or fine jaw crusher depending on your requirements on the finished product size and shape. Cone crusher or fine jaw crusher is a cost-effective option when the particle size and shape of the stone is not demanding.Read More
May 06, 2020 Different types of crushers. There are three types of crushers. Types of crusher depend on the feeding method. These are- Primary crusher, Secondary crusher and Tertiary crusher. The primary crusher is only for the breaking of large stones into pieces (this means primary crusher is not for the aggregate size material.).Read More
Cone crushers are used in secondary and tertiary roles as an alternative to impact crushers when shape is an important requirement, but the proportion of fines produced needs to be minimized. Impact crusher. An impact crusher uses mass and velocity to break down feed material.Read More
Required performance of secondary crusher Required feed size for the cone crusher In selected example: Tooth shape of crusher jaws: Regular Teeth Crushing gap CSS: 90 mm (optimal capacity) Cone crusher: Adjustment of the cone crusher, see page 188, acc. to chap. "Setting up cone crusher", depending on Desired grading curveRead More
Difference Between Primary Crusher And Secondary Crusher. A Jaw Crusher Is One Of The Main Types Of Primary Crushers In A Mine Or Ore Processing Plant The Secondary Stone Cone Crusher In Canada. How The Shape Products Stone Of Secondary Crusher , Secondary Stone Cone Crusher In Canada , What Is The Difference Between Jaw Crusher And SecondaryRead More
The impact crusher often manufactures products in good shape, with little angularity and more powder; but the cone's finished product has more needle-shaped pieces and poorer shape. For the sand maker, its finished products are cubic in excellent shape and uniform size.Read More
Jan 07, 2012 Jaw Crusher Overview. Jaw Crusher is one of the main types of primary crushers in a mine or ore processing crusher plant and also is one of the most widely used crushing equipment in mining industry. This series of jaw crusher can reach the crushing ratio of 4-6 and the shape of final product is even. Because it is primary crusher, Jaw crusher is designed for long life service with …Read More
The Crusher is designed to Crush in two or three stages for minimum wear and tear of parts; the incoming feed first strikes the blow bars on the rotor and is then impacted on the primary curtain. When the material is reduced to a stage where it can pass the primary curtain, it is then impacted on the secondary curtains where the final sizing of ...Read More
how the shape products stone of secondary crusher. The products includes five series: crusher, sand making machine, powder grinding mill, mineral processing equipment and building materials equipment.Different Types Of Secondary Rock Crusher.gyratory crusher is a type of secondary rock crusher. there is a narrow opening at the bottom of gyratory crusher. only if the stone is crushed intoRead More
European impact crusher is mainly used in metallurgy, mine, cement, chemical engineering, fire resistant materials, ceramics and other industrial sectors, as well as in the expressway construction, water conservancy project, building crushed stone, and machine-made sand process fields, etc.Read More
how the shape products stone of secondary crusher. size and shape stone with secondary crushers. secondary crushers continue the process of the crusher can be equipped to operate between 100 and 275 usgs reports . Inquiry OnlineRead More
Secondary Impact crusher is secodary stage rotary type crusher, which is commonly used to break down middle size stone product into sand-gravel size final product. As usual, cubic shape output product of secondary impact crusher is directly used in concrete plants and other construction areas easily, thus it is more preferred for second-third ...Read More
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Interest Rate Changes – What Impact Will They Have
There has been a great deal of media hype regarding the reserve banks recently announced interest rate change on the 3rd of February 2015
Unlike many of the previous interest rate announcements, a vast majority of lenders passed the rate cut in full to their home loan products, with some bank even passing on a greater amount than the 0.25% announced by the Reserve Bank.
While most people will look at how an interest rate reduction will save money on their mortgage repayments, it is worth noting what lies behind this decision, and what will be the longer term impact of the Reserve Bank's announcement.
Typically the Reserve Bank will look to reduce interest rate as a way of increasing economic activity, by putting more money in people's pockets (by way of lower loan repayments). The theory is that this will allow people to spend more money on everyday items to help lift the economy.
Since the Global financial crisis, we have seen a trend where people have taken the money saved from an interest rate cut, and used this as an additional repayment on their home loan. Or have simply saved this money for a rainy day. As a result of not directly spending these savings, the impact on the economy from an interest rate cut maybe having a smaller impact that it has in the past.
Time will tell what impact the recent interest rate announcement will have on the housing market and the broader economy as a whole.
For more information on interest rates, and how these can impact on your home loan, feel free to contact one of the friendly representatives at Top Mortgages on 1300 308 225


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Eighteen of the 30 MLB teams have a positive run differential in The Athletic Alternate Universe. Fifteen of those 18 are above .500, and many of them have earned it. When you outscore your opponents by 139 runs across 79 games, as the Astros have, or 117 runs in 81 games, like the Dodgers, you're likely to be comfortably better than .500. Others, like the Diamondbacks, who are somehow nine games over .500 despite scoring just seven more runs than their opponents, or the Twins, who are 44-38 with a run differential of just plus-12, have received more than their fair share of good fortune.
It appears we build fortune pipelines in this alternate universe, and one of those is running downhill from the North Side of Chicago, perhaps with stops in Phoenix and the Twin Cities.
At plus-72, the alternate universe Cubs have the fourth-best run differential in the game.
The four teams ahead of them — the Astros, Dodgers, and Rays — are a combined 53 games over .500. The Astros and Rays lead their respecitve divisions and have the best and third-best records, respectively, in the majors. The teams immediately behind the Cubs in run differential are the first-place Cardinals (plus-68) and 48-33 Indians (plus-65), who lead the AL wild-card standings, and are a half-game behind the Royals for first in the AL Central.
The Cubs are 38-42.
It's not supposed to be like this. You're not supposed to outscore your opponents by nearly one run per game and be under .500 at all, let alone four games under. The Cubs' Pythagorean expectation, the Bill James formula, calculates a team's record based on run differential. Going by that metric, the Cubs should be 46-34. At minus-8, the Cubs have the greatest negative differential between Pythagorean expectation and actual record in our alternate universe. In case you're wondering, Pythagorean expectation typically tracks closely with a team's actual wins and losses. For example, the greatest negative differential last year in the actual baseball universe was minus-6. It belonged to … dammit.
Is there something elemental about this version of the Cubs that makes them particularly unlucky? Is there something in the way they're built that leads to a gaming of Pythagorean expectation where the math is better than the on-field results? The answer to both of those questions is maybe.
The first place you want to look when trying to explain a negative spread between Pythagorean expectation and actual record are one-run games. The real-life Cubs went 19-27 in one-run games in 2019. The alternate universe Cubs are 6-11 so far.
Our last three losses, and four of our last six, have been by one run. That included a 6-5 loss to the Mets where Rowan Wick gave away the lead in the eighth and an 8-7 loss to the Reds in which Craig Kimbrel served up a walk-off, three-run homer to Mike Moustakas. The alternate universe Cubs held the lead going into the eighth inning in seven of their 11 one-run losses. They led another going into the seventh. The backend of the bullpen needs some reinforcements.
At the same time, the team might not be as good as the run differential suggests. Through 80 games, the alternate universe Cubs have won five games by at least 10 runs, including a 23-6 win over the Red Sox in the most recent simulation. The 2019 Astros had the best run differential and record in the majors in 2019 and ranked third in runs. They won 10 games all season by at least 10 runs. The alternate universe Cubs have won six more games by between seven and nine runs. This team can tack on essentially meaningless runs with the best of them, and that could be inflating the Pythagorean expectation through the first half of the season.
Personnel changes
We'll be looking to make a move or two in the bullpen with a month to go until the trade deadline, but the wheeling and dealing has already begun. Last week, we engaged Astros GM Al Melchior in talks about a deal centered around José Quintana for Michael Brantley.
We were initially looking for help in the rotation, but with Alec Mills and Adbert Alzolay both throwing the ball well, we thought the help could come from within and that we could use another pitcher to strengthen an already strong offense. Then Jason Heyward and Steven Souza suffered injuries that required trips to the IL (more on Souza's injury in a moment), which made that trade a no-brainer. Hours after getting the Heyward and Souza news, we made it official with Melchior, sending Quintana to Houston for Brantley. The fans are pumped.
Don't worry, we won't take advantage of your slightly increased interest to bump up beer prices. Brantley has taken well to his move to Chicago, going 13-for-24 with two doubles, six RBIs and three walks in his first six games with the team. We've got him hitting fourth against righties and fifth against lefties, sliding the struggling Kyle Schwarber down into the six-spot.
Injury update
Heyward and Souza hit the IL on the same day. A strained hamstring landed Heyward on the IL with an initial four-week timetable. He'll be sidelined for another week or two before getting back with the team? Ho-hum, right? Strained hamstrings happen all the time. The simulation must have felt bored after that one because it stepped up its imagination for Souza.
There's being snakebit, there's being injury prone, and then there's being the guy who endures his second IL stint in a season because he has trouble putting one foot in front of the other while walking down the stairs. See you in a couple of months, Souz.
Jon Lester is on the verge of wrapping up a rehab stint with Triple-A Iowa. He should be back with the big league club the next time we convene in this space.
Stats update
The song remains the same here. Anthony Rizzo, Kris Bryant and Javy Báez are carrying the offense. Look at these studs…
Willson Contreras has turned it on, as well. At the end of play on May 23, he was hitting .191/.289/.420 with seven homers. Going into play on June 25, he's slashing .269/.358/.529 with 12 homers, ranking third among catchers in OBP, second in slugging and third in OPS.
Yu Darvish is still doing his thing, pitching to a 3.45 ERA and 1.19 WHIP with 112 strikeouts against 31 walks in 101 2/3 innings. He hasn't earned a win in more than a month, but has lowered his ERA nearly half a run in that span.
With Lester on the IL and Quintana in Houston, Alec Mills and Adbert Alzolay have joined the rotation. Mills, who had been thriving as a long man in the bullpen, looked great in his first start, limiting the Red Sox to one run on eight hits in six innings, striking out two and walking three. Alzolay has made four starts, amassing a 4.84 ERA, 1.52 WHIP and 23 strikeouts in 22 1/3 innings. He's coming off his best start to date, a six-inning, one run, four-hit, six-strikeout gem in that 23-6 win over the Red Sox. (Nico Hoerner carried the big stick in that game, going 4-for-5 with a double and six RBIs.)
When Lester returns, Alzolay or Mills will go to the bullpen. Mills has been great in his relief role already this season, but Alzolay could also be the weapon the team needs to stabilize the endgame. Check out our team stats and share your thoughts as to who should stick in the rotation in the comments.
Around the league
Grant Brisbee is taking a leaguewide view of The Athletic Alternate Universe every Friday. We've run one more simulation since his column from last week, but little has changed since then. The Royals and Diamondbacks are still inexplicably first-place teams. The Pirates have somehow won eight straight games and are just a half-game behind the Cardinals in the NL Central. The Astros, Braves and Rays have comfortable leads in their respective divisions. The Orioles, Tigers, Rangers, Giants, Brewers and Marlins are terrible.
Bryce Harper is back to MVP form, hitting .341/.455/.693 with 25 homers and 61 RBIs. Mike Trout leads the majors with 5.5 WAR, nearly half a win better than Alex Bregman, who's in second. Another AL West slugger, Matt Olson, leads the league with 33 homers. All three figure to be in the AL MVP race.
Manny Machado is enjoying his second year with the Padres, slashing .348/.406/.591 with 20 homers and 64 RBIs. Corey Seager has bounced back from injury, hitting .321/.377/.529 with 14 homers and a league-leading 76 RBIs. Vlad Guerrero Jr. has 53 extra-base hits, 30 of which are dingers, and a .681 slugging percentage. Ronald Acuña has 23 homers and 21 steals, so we'll be on 40-40 watch the rest of the year. Blake Snell is 11-0 with a 1.25 ERA. Daniel Norris has somehow already lost 14 games. Gerrit Cole (146 strikeouts) and Max Scherzer (143) are both making runs at the 300-strikeout mark. Shane Bieber has fanned nearly nine batters for every one that he's walked, yet sports a 5.22 ERA in 100 innings. Jonathan Villar has been caught stealing 23 times. Twenty-three! The single-season record is 42, set by Rickey Henderson in 1982, but at least he stole 130 bases that year. Villar has just 17 steals in the alternate universe. Inefficient and TOOTBLAN'ing is no way to go about being a base-stealer, Jonathan. Man, this would all be a lot more fun if it were for real.
Next up
Our next round of simulations will take us up to the All-Star break. The Cubs will play 16 games in that time, a brutal stretch that includes three games apiece with the Yankees, Rays and Braves, and two across town against the White Sox at Guaranteed Rate Field. Here's to hoping Pythagoras and Bill James are onto something.
(Photo: Jon Durr / USA Today)


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Is earnest money required for a VA loan?issuing time: 2022-07-22
Quick navigation
- If so, how much is typically required?
- What is the earnest money used for?
- How is the earnest money protected?
- When do you need to provide earnest money?
- What happens to the earnest money if the deal falls through?
- Can the seller keep your earnest money if you back out of the contract?
- How does having Earnest Money affect getting a loan from a bank or other financial institution?
- Who holds on to the buyer's earnest deposit until closing day?
- Do I get my full deposit back if I cancel after an inspection reveals problems with the home that I don't want to fix or can't afford to fix?
- Under what circumstances would I be entitled to a refund of my entire deposit without penalty?
- What are some common misunderstandings about Earnest Money Deposits (EMD)?
- Does putting down an EMD make me more likely to have my offer accepted by a seller over another offer that did not come with an EMD?
Yes, earnest money is required for a VA loan. The amount of earnest money you must deposit will depend on the type of loan you are applying for and the lender's policy. Generally, lenders require between 3% and 5% of the total purchase price as earnest money.
If so, how much is typically required?
If you are seeking a VA loan, earnest money is typically required. This means that the lender requires a down payment before they will approve your loan. The amount of earnest money typically varies depending on the type of VA loan you are applying for, but it is generally somewhere between 3 and 5 percent of the total cost of your home. If you do not have enough earnest money available, your lender may be able to provide you with a bridge loan or another form of financing until you can come up with the full amount.
What is the earnest money used for?
Eager money is used as a guarantee from the lender that they will receive their full investment back if the borrower defaults on their loan. This money is also put into escrow to ensure that all obligations are met by the borrower before any proceeds are released.
The earnest money is typically put down as a percentage of the total amount borrowed, so it's important for borrowers to understand what this term means and how it affects their loan application. If you have questions about earnest money or your va loan, don't hesitate to reach out to your lender or financial advisor.
How is the earnest money protected?
Eager money is the money that a lender gives to a borrower as an incentive to close on a loan. The earnest money is usually protected in two ways: first, the lender may require the borrower to put up some of their own cash as earnest money; and second, if the loan goes into default, the lender may be able to seize any assets that were pledged as earnest money.
When do you need to provide earnest money?
If you are getting a VA loan, you will need to provide earnest money. This is money that you put down as a guarantee that you will actually use the money to purchase the home. If you do not provide earnest money, your lender may not approve your loan.
What happens to the earnest money if the deal falls through?
When you get earnest money from a lender, it's like putting down a deposit on a property. If the deal falls through, the earnest money is your security and you can get it back. The lender may also give you a break on your closing costs if the deal falls through.
Can the seller keep your earnest money if you back out of the contract?
When you get a VA loan, the government will put up some of the money to help you buy your home. If you decide later that you don't want to buy the home, the seller can keep your earnest money.
There are a few things to consider if you're thinking about backing out of a contract: first, make sure that you have all of your paperwork in order (contract, appraisal, etc.) and second, be prepared to explain why you're leaving. The seller may not be happy with your decision but they should understand and respect it. Keep in mind that if you back out after giving the seller advanced notice, they may still have to refund your earnest money - it's up to their discretion.
How does having Earnest Money affect getting a loan from a bank or other financial institution?
Earnest money is a term used in the lending industry to describe a loan that has been pre-approved and subject to certain conditions. When you get earnest money on a va loan, it means that the lender is already convinced that you can repay the loan, and they are only waiting for some final paperwork from your bank or other financial institution before making the funds available.
Generally speaking, lenders will be more willing to approve a va loan if you have earnest money backing it up. This is because lenders know that they can trust you to repay the debt, even if things don't go as planned financially.
Having earnest money also helps speed up the process of getting approved for a va loan. Lenders want to make sure they are getting their money back as quickly as possible, so having an assurance from your bank or other financial institution that you will be able to repay the debt is key.
Who holds on to the buyer's earnest deposit until closing day?
When you get earnest money from a buyer, the lender typically holds on to that deposit until closing day. This is done in order to ensure that the buyer actually closes on the property and doesn't back out at the last minute. If the buyer does back out, then the earnest money is lost and the lender may not be willing to give you any more money for your next purchase.
It's important to keep this in mind when negotiating a deal with a potential buyer.
Do I get my full deposit back if I cancel after an inspection reveals problems with the home that I don't want to fix or can't afford to fix?
When you buy a home, it's important to have all the facts about your loan. This includes understanding how earnest money works and whether or not you can get your full deposit back if you cancel after an inspection reveals problems with the home that you don't want to fix or can't afford to fix.
Here are some answers to common questions about earnest money:
Can I get my earnest money back if I cancel after an inspection?
Yes, typically you can receive your earnest money back minus any costs associated with the cancellation, such as closing costs. However, there may be specific circumstances where this isn't possible (for example, if the home has been damaged beyond repair).
What happens if I don't use my earnest money?
If you don't use your earnest money, it's usually considered lost funds and won't count against your total down payment or mortgage amount. You may still be able to use it for other purposes (such as paying off high-interest debt), but it will reduce the available funds for using on your purchase.
Is there a limit on how much I can get back?
There is no set limit on how much you can receive back from lenders for their earnest money contribution - each situation is different and depends on lender policies. However, most lenders will only allow a certain percentage of deposits to be used in this way. For example, some lenders might allow up to 50% of deposits to be used in this way.
Under what circumstances would I be entitled to a refund of my entire deposit without penalty?
When you make a loan with the VA, you are required to put down a deposit. If you decide that you do not want the car after all, and return it within 30 days of taking possession, then your entire deposit (less any fees) is automatically refunded to you without penalty. If you return the car more than 30 days after taking possession, but less than 60 days, only the portion of your deposit that was used for costs associated with the car (such as title transfer or registration) is refunded to you. Any remaining deposit is forfeited by VA.
In addition, if there were any damages to the vehicle beyond normal wear and tear when it was returned, only the cost of those damages is refunded. Finally, refunds are not given for cars that have been sold or traded in.
What are some common misunderstandings about Earnest Money Deposits (EMD)?
Earnest money deposits are a way to protect yourself from fraud in a home purchase. When you make an earnest money deposit, the seller agrees to hold onto the deposit until you receive your full purchase price and any escrow or closing costs have been paid.
Some common misunderstandings about EMDs include:
-EMDs don't guarantee that you'll get your full purchase price back.
-EMDs aren't a form of insurance.
-You can't use EMDs to buy a home if you're already living in it.
-If the sale falls through, the seller can keep your EMD without giving you back your original investment.
Does putting down an EMD make me more likely to have my offer accepted by a seller over another offer that did not come with an EMD?
When you are buying a home, it is important to be aware of earnest money. EMD stands for earnest money deposit. This is a down payment that the buyer makes to show their seriousness about purchasing the home.
Some people believe that putting down an EMD makes them more likely to have their offer accepted by a seller over another offer that did not come with an EMD. However, this is not always the case. There are many factors that go into whether or not a seller will accept an offer, and the amount of earnest money put down may not be one of them.
If you are interested in purchasing a home, it is important to research all of your options and make sure you are making the best decision for yourself and your family.


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Kitchens edmonton
Find the best restaurants in Edmonton and get the food you want delivered. Order food online now! Cheesecake Factory Bakery by Ghost Kitchens. 12 - 22 mins. Cora Breakfast & Lunch. 20 - 30 mins. George's BBQ Chicken & Ribs by Ghost Kitchens. 29 - 39 mins. Happy pizza 24/7. 24 - 34 mins. Welcome to Canterra Suites one of the Best Hotels in Edmonton, Alberta. Stylish, spacious suites with full, modern kitchens — experience the big city from the comfort of your private retreat. View Availability Our Rooms. There's no place like it. Nothing compares to the feeling of coming home, but we've come close to capturing it. At Sandman Hotel Edmonton West, you'll find that we have a variety of expansive meeting rooms and banquet halls. For that home away from home feeling, our Executive Tower (connected to our main building) houses rooms, including some with mini kitchens, as well as our King Suites and penthouse Jacuzzi King Suite.
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Outdoor kitchens and BBQs. Beachcomber Hot Tubs & Patio is an authorized dealer of Bull Island Outdoor Kitchens and proudly offers all custom options. With 's of different colors and materials we can make your kitchen one of a rest easy knowing you have some of the best quality cabinets in Edmonton. Sultan's Kitchen, Edmonton: See 4 unbiased reviews of Sultan's Kitchen, rated 4 of 5 on Tripadvisor and ranked # of restaurants in Edmonton. (Kitchen Cabinets Painters Edmonton, AB): Affordable Kitchen Cabinets Painting, Staining, Refinishing, Refacing & Resurfacing in Edmonton. FREE Estimate. 3D Custom Cabinets: We are Edmonton Alberta based custom cabinet makers. We pride ourselves in being a Canadian manufacturer that can customize cabinets to. Celtic Kitchen supplies Edmonton with home-made pies inspired by Scottish, Irish, Welsh and English cuisine. Order online.]
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Illegal animal slaughter banned on Eid in Assam!
Assam News Desk !! The Assam Home Department in a notification on Friday directed officials to take steps to check illegal killing of animals, including cows, on the occasion of Eid. Joint Secretary K.K. Sharma has written a letter to all the deputy commissioners and superintendents of police in the state to take measures to prevent illegal killing of cows, calves and other animals during the upcoming Eid. He has also recommended action against criminals for violating animal rules on Eid. Sharma has cited references to letters from the Animal Welfare Board of India (AWBI), Ministry of Fisheries, Animal Husbandry and Dairying of the central government.
AWBI communication sent to all states on June 7 mentions that a large number of animals are likely to be slaughtered during Eid. But, while transporting animals, some owners of animals do not follow the laws that result in cruelty to animals. Also, as per the Prevention of Cruelty to Animals Rules, 2001, camels cannot be killed for food at all. Also, wherever the Prohibition of Cow Slaughter Act is in force, the slaughter of cows should not be allowed at all.


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Masculine and feminine energy are like a fire. if you can master your masculine energy you can control your fire and use it as a light but if lose control of your fire, you can burn everything down.
The only way to master your masculine energy is with discipline. You need to give yourself instructions and then follow your instructions. It takes discipline to follow your own lead.
Once she notices that you have mastered your energy, her energy will yield to you with very little effort from you.


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Furtopia | Family Friendly Furry Forum and IRC Chat!
not-so-furry discussion => news forum => Topic started by: Old Rabbit on January 07, 2018, 12:28:37 pm
The GOP is working to add a balanced budget amendment to the constitutions.
Post by:
Old Rabbit
January 07, 2018, 12:28:37 pm
Since 2010 the GOP with the Tea party have been using their
political control of several states to set up a constitutional
convention. They plan to add a balanced budget amendment
and who knows what else to change our constitution according
to their agenda of reducing the federal government.
This of course would save the riches amercians millions in
taxes. Having a balanced budget sounds good, but
it will end up hurting those who depend on retirement
funded by the federal government. Civil servvice retirees
across the nation along with those on social security could
loose a significant amount of their monthly retirement. Why?
Because with a constitutional amendment congress would
be required to cut all services. Even military retirees
will have their checks cut too if required.
Some might think this won't affect me, but
when we have economic recessions, it's those
recieving payments from the federal goverment
who help keep the ecomomy afloat. Otherwise
many jobs would be lost due to small businesses
closing in a economic recession. This job loss
will only deepen any recession which wiould
affect everyone. When people loose their
jobs they can't make payments on their homes
or to pay for anything on credit.
The GOP has 28 states, and they only need
a total of 34 to open the convention. This
shows we must stop this rush to protect the
upper class, which will end up hurting us all.
The following link goes into more detail on
this subject.
https://www.cbpp.org/research/constitutional-balanced-budget-amendment-poses-serious-risks (https://www.cbpp.org/research/constitutional-balanced-budget-amendment-poses-serious-risks)
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U.S. Rep. Henry Cuellar, a nine-term incumbent and the last anti-abortion House Democrat, avoided defeat in Tuesday's Democratic primary in Texas – but will head to a runoff against progressive immigration attorney Jessica Cisneros, according to The Associated Press.
Dems Cuellar, Cisneros head to runoff in Texas US House primary
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What Is Weather Gauge?
- Weather gage and gauge in carrier operations
- The Battle of the Wind
- How to Measure Rain
- A New Type of Active Sensor for Rain Gauge
- The first radar
- How Much Snow is There?
- Measurement of rain-water in a funnel
- Measurement of Weather Using Rain Gauge
- Automated Weather Stations
- Atmosphere and weather
- Tides in the Maritime Environment
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Weather gage and gauge in carrier operations
The weather gage is used in carrier operations. If the aircraft carrier is steaming into the wind, it will generate stronger winds across the deck that will allow for a lower actual speed. The Battle of the Philippine Sea is a notable event that benefits carrier operations.
The American carriers were angry. The range was opened to the Japanese fleet when an American aircraft carrier conducted flight operations. Alternative spellings are often used with the gage and gauge.
The Battle of the Wind
The first phase of the battle would be a race to get the wind. A ship can have the weather gage if it says that one ship is windward of another ship. To be windward means that the wind comes from the other side.
If one ship is windward of another, it is "upwind" of it. Being upwind from the enemy is what holding the weather gage is all about. To take the wind out of his sails was a maneuver in which one vessel would pass close to another, blanketing the breeze from the other's canvas and making him lose way.
How to Measure Rain
As far back as the 4th century, measuring rain was a long-drawn practice. Records were kept for comparing and weighing. The mechanism of therain gauge was invented in the 13th century.
The fundamental unit of rain gauge has been developing in different ways since then. The purpose and concept are the same. The Rain Gauge is a meteorological instrument that is used by hydrologists and meteorologists to measure the rain precipitation in a given amount of time per unit area.
It is also known by the names of udometer, pluviometer, and ombrometer. What is 1 inch of rain? Is it new or old?
The last month has seen 1 inch of rain, but it is only 15 minutes since then. You must be wondering how the rain is measured. That is very simple.
You have to check the scale in the glass to see the water level. Rain gauge are used to measure the rain precipitation, there are different types of rain gauge. One thing that can be assured is that you will get a good idea of the amount of rain your area from all the methods.
A New Type of Active Sensor for Rain Gauge
A rain gauge with a better resolution will have a lower limit on the maximum rain rate it can measure accurately. The most popular type of rain gauge is self-emptying tipping-bucket. The BARANI DESIGN MeteoRain is one of the new designs and historically popular designs include Pronamic, Davis Instruments and RainWise rain gauge.
The first radar
A weather instrument that measures air pressure is a barometer. Aneroid is more widely used than mercury in barometers. Most official weather stations use digital barometers.
Evangelista Torricelli is credited with inventing the barometer. The first rain gauge was developed in 1441 by the Joseon Dynasty of Korea, which is when the first known rainfall records were first recorded. The rain gauge is one of the oldest weather instruments.
When radar was first used as a defense mechanism, military personnel noticed noise from precipitation their radar displays, which led to the identification of radar as a potential scientific tool. Radar is an essential tool for predicting precipitation in storms. Weather instruments are necessary, but they can't replace human expertise.
How Much Snow is There?
10 inches of snow is equivalent to one inch of rain, but that's only an average. An observer can't assume that 10 inches of snow has fallen if a rain gauge shows one inch of water. The snow depth can only be determined by measuring it.
The depth is determined by taking an average of three or more spots. A ruler is stuck in the snow and recorded. It is not always easy to determine three or more representative locations because of blowing and drifting.
Measurement of rain-water in a funnel
A funnel of copper or polyester usually allows rain-water to collect in an enclosed bottle or cylinder for measurement. The gauge is set in the open ground with the funnel rim up to 30 cm above the ground surface. The amount of rain can be read directly from the gauge, but it must be calculated from the depth of water in the container and the dimensions of the funnel.
Measurement of Weather Using Rain Gauge
Rain gauge are some of the most basic tools used to measure weather. It was created for agricultural purposes. The rain gauge is still used to measure climate, weather patterns and monitor disasters.
The rain gauge collects rain water into a funnel. The cup has a funnel that empties the rain water into it. The shape of the funnel helps keep out leaves.
The water is sitting in a cup. An observer can see how much rain fell after the storm has passed. A collection of observations from several rain gauge can help a meteorology professor see what areas had the most rain.
The data can be used to monitor the weather. Monitoring the weather is one of the most important uses for rain gauge. Farmers rely on rain to water their crops.
If the rain gauge shows little or no rain for a long time, the crops are at risk of dying. The rain gauge shows a lot of rain over a period of weeks or months. It can give a farmer a heads up on a flood.
Automated Weather Stations
An automated weather station is a different type of weather station. They can be part of a weather network. Automatic weather stations are the standard for meteorology.
The rain gauge is the next important piece of an automatic weather sensor. The rain gauge measures precipitation. A rain gauge is a cylinder.
A weather camera is one of the last components of a weather station. Not every weather station has a weather camera. Weather cameras show live images and connect communities.
One of the most popular uses for weather stations is a school weather station. There are many reasons why schools install automated weather stations. Student safety, event planning andSTEM education are the three biggest reasons.
School weather stations are installed for the safety and planning benefits. There are a lot of weather-related risks that can threaten students, faculty, visitors, and equipment. The vital information that a school weather station can give is important to the decision-makers.
Atmosphere and weather
The atmosphere and the weather are related. It includes the outside temperature, strength of the wind, and whether it is raining or snowing. The weather varies across different countries and seasons.
Summer is warmer and winter is colder, with more rain, sleet, hail and snow. Some countries are warm all year round, while others are cold all year round. A large section of cold dry air is bashed into a large section of warm moist air.
Storms tend to have strong winds. There is often rain, sleet, hail, and thunder. The climates towards the north and south of the earth are very different.
The polar regions of Russia, Canada, and Greenland have a tundra climate. They have long cold winters and hot summers. There are weather stations on the ground that are away from buildings and hills.
Tides in the Maritime Environment
The rise and fall of the tides can have a significant effect on maritime activities. The San Francisco Tide Station has been in operation for more than 150 years. Older tide houses had similar design to newer tide station enclosures that protect sensitive electronics, transmit equipment, and backup power and data storage devices.
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The PHSMB wrapped up their competition season with a third state qualifying Superior rating, and the highest score of the year, taking 2nd place in AA, and 2nd place overall out of 18 bands. In addition, they scored the highest music score in PHSMB history. This marks the 7th consecutive Superior rating for the Marching Panthers!
Enjoy your Tuesday afternoon off, and be ready to start State preparation on Wednesday!


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A-1 BAKERY & Châterais... (LG1-51)
"Disney . Love Nature"
21st July - 14th August
This summer, Festival Walk is proud to host "Disney . Love Nature" featuring Disney's classic cartoon characters donning nature-themed outfits to go on a green adventure. Join us to explore the beautiful mysteries of nature! Disney fans, don't miss the debut of new Disney "Go Green" products!
"Disney . Love Nature" Decoration & Pop-up Store
Venue: Level LG2
11:30 am - 8:00 pm (Mon - Thu)
11:00 am - 9:00 pm (Fri - Sat)
11:00 am - 8:00 pm (Sun)
My FESTIVAL Member Privilege Exclusive Limited-edition Tote Bag Redemption
Limited Edition "Disney . Love Nature" Tote Bag! Act Now!
Exclusive offer for My FESTIVAL members only! Simply reserve a Supreme Pass with 20 bonus points, then spend HK$800 or above in a single transaction at Festival Walk, and take home with you this adorable limited-edition "Disney . Love Nature" tote bag*!
Venue: Concierge (UG)
Time: 11:00 am - 10:00 pm
Please browse "My FESTIVAL" > "Redemption" > "Disney . Love Nature" of Festival Walk app to check the details.
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The file type is
CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization
Nucleic Acids Research
DATABASE CONTENT Sources of CTCF-binding sites We expanded the CTCFBSDB using data from a variety of sources containing CTCF-binding sites determined using genome-wide experimental methods, and CTCFBSDB ... Figure 1 . 1 Screenshot of an example webpage for a CTCF-binding sequence (ENCODE_OC_hg18_MCF-7_744758) in CTCFBSDB 2.0. ...doi:10.1093/nar/gks1165 pmid:23193294 pmcid:PMC3531215 fatcat:shjkjekgxbemzdhlhr4s6ilpzu
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators
Nucleic Acids Research
We have constructed a CTCF-binding site database (CTCFBSDB) to characterize experimentally identified and computationally predicted CTCF-binding sties. ... CTCF-binding sites were found to be commonly distributed along the vertebrate genomes. ... Lander for providing the predicted CTCF motifs and Dr Keji Zhao for providing the genomic coordinates of 20 262 CTCF-binding sites. ...doi:10.1093/nar/gkm875 pmid:17981843 pmcid:PMC2238977 fatcat:hkwuws73qjc6dek6nzsodiuesq
TET-catalyzed 5-carboxylcytosine promotes CTCF binding to suboptimal sequences genome-wide
Dramatically, profiling of CTCF binding in a cellular model that accumulates genomic 5caC identified ∼13,000 new CTCF sites. ... The new sites were enriched for overlapping 5caC and were marked by an overall reduction in CTCF motif strength. ... Genome Biol 9, R137. Ziebarth, J.D.,Bhattacharya, A., and Cui, Y. (2013). CTCFBSDB 2.0: a database for CTCFbinding sites and genome organization. Nucleic Acids Res 41, D188-194. ...doi:10.1101/480525 fatcat:migehw6eyfguldhohog5f6vyfa
Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved
Developmental Biology
In zebrafish, cohesin binds to the transcription start sites of p53 and mdm2, and depletion of either Rad21 or CTCF increased their transcription. ... Cohesin bound the transcription start site plus an upstream predicted CTCF binding site at zebrafish myca. ... advice on ChIP and Mike Eccles for helpful discussions. ...doi:10.1016/j.ydbio.2010.05.493 pmid:20553708 pmcid:PMC2941799 fatcat:rahduisgxfayljdncv66tamcma
A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation
Nucleic Acids Research
Here, we show that, in addition to constitutively bound CTCF binding sites (CTS), the CTCF cistrome comprises a large proportion of sites showing highly dynamic binding patterns during the course of adipogenesis ... Our study reveals a dynamic CTCF chromatin binding landscape required for epigenomic remodeling of enhancers and transcriptional activation driving cell differentiation. ... We also acknowledge the CNRS U8199 genomics platform for the processing of hMeDIP-seq samples. B.S. is a member of the Institut Universitaire de France. ...doi:10.1093/nar/gku780 pmid:25183525 pmcid:PMC4176165 fatcat:c6w242ndpnaprcsjzld73k3lfm
Natural Antisense Transcript PEBP1P3 Regulates the RNA Expression, DNA Methylation and Histone Modification of CD45 Gene
Knockdown of PEBP1P3 also increased the binding levels of chromatin conformation organizer CTCF at intron 2 and the alternative splicing exons of CD45. ... PEBP1P3 is a natural antisense transcript from the opposite strand of CD45 intron 2 and is predicted to be a noncoding RNA. ... Acknowledgments: We thank Liyan Xu from Shantou University for her scientific and technical support and Xiaojun Xie from Shantou University for his critical reading of the manuscript. ...doi:10.3390/genes12050759 pmid:34067766 pmcid:PMC8156488 fatcat:epl3ypaxzjhyjbkt3sir7ogjt4
Genomic Space of MGMT in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression
International Journal of Molecular Sciences
ChIP analysis verified the binding site in MGMT promoter for CTCF which regulates the genomic methylation and chromatin looping. ... Extensive genome database analyses showed that the MGMT genomic space was rich in and harbored many undescribed RNA regulatory sequences and recognition motifs. ... Acknowledgments: We thank Ibtisam Ismael Al-Obaidi and laboratory personnel for technical assistance. Conflicts of Interest: The authors declare no conflict of interest. ...doi:10.3390/ijms22052492 pmid:33801310 pmcid:PMC7958331 fatcat:2df5kixhvbebtmb6blc6qqojj4
Functional signatures of evolutionarily young CTCF binding sites
BMC Biology
Remarkably, we discovered a recurrent regulatory architecture consisting of a CTCF binding site and an interferon gene that appears to have been tandemly duplicated to create a 15-gene cluster on chromosome ... Conclusions Our results demonstrate that thousands of CTCF binding sites show multiple functional signatures rapidly after incorporation into the genome. ... Acknowledgements We thank Maša Roller for the support and for a critical reading of the manuscript and suggestions for its improvement. ...doi:10.1186/s12915-020-00863-8 pmid:32988407 pmcid:PMC7520972 fatcat:5m5sy772d5dkpcg2x74zj2o7be
Identification and characterization of two functional variants in the human longevity gene FOXO3
Nature Communications
In summary, we present experimental evidence for a functional link between common intronic variants in FOXO3 and human longevity. ... FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. ... The biobank PopGen and the PopGen 2.0 network are also financed by the BMBF (grant 01EY1103). ...doi:10.1038/s41467-017-02183-y pmid:29234056 pmcid:PMC5727304 fatcat:xdqocw7xdbfxnmyrhqmqsk6dm4
CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites
Cell Reports
We identified CTCF sites in pericentric/centromeric DNA and found that, early in mitosis, CTCF binds and recruits CENP-E to these sites. ... Unlike most known CTCF genomic sites, the CTCF-binding sites in the pericentric/centromeric regions interact strongly with the C-terminal fingers of CTCF. ... Gaelle Lefevre and Dr. Gregory Riddick as well as other members of our laboratory for their help. We also thank Dr. Don W. Cleveland for the CENP-E plasmid. ...doi:10.1016/j.celrep.2015.08.005 pmid:26321640 pmcid:PMC4633288 fatcat:gozmssrblnc6dn6suh2hmmalxa
The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma
Journal of Pathology
CCCTC-binding factor (CTCF) is a DNA-binding protein that interacts with a large number of highly divergent target sequences throughout the genome. ... It is implicated in a variety of functions, including chromatin organization and transcriptional control. The functional role of CTCF in tumour pathogenesis remains elusive. ... histological diagnosis; RZ, TKWL, EYTL, NPYH, XZ, VK, LMCC, ASC: contributed to animal studies; KWC, HKW: helped with microarray analysis; BCBK: responsible for the design and analysis of the experiments ...doi:10.1002/path.4976 pmid:28862757 pmcid:PMC5725705 fatcat:f5aeer2gkzev7munnbmaxr3oty
Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer
BMC Cancer
These regions are generally enriched for CpG islands, Lamin Associated Domains and Large organized chromatin lysine modification domains, and are associated with stochastic variability in gene expression ... Result: We found that the classical promoter epigenomic mark -H3K4me3, is highly enriched at HMB boundaries, as are CTCF bound sites. HMB boundaries harbor distinct combinations of TF motifs. ... Acknowledgements Authors would like to thank Joyce Hasio, and Rukhsana Yeasmin for reading the manuscript and providing helpful comments. ...doi:10.1186/s12885-016-2128-1 pmid:26868017 pmcid:PMC4750190 fatcat:enbzth57wnajfemupnezlplkwa
Integrative genomic analysis of human ribosomal DNA
Nucleic Acids Research
Fourth, UBF, a positive regulator of rRNA transcription, binds to sites throughout the genome. ... Lastly, the insulator binding protein CTCF associates with the spacer promoter of rDNA, suggesting that transcriptional insulation plays a role in regulating the transcription of rRNA. ... We also thank Batool Akhtar-Zaidi, Greg Crawford, Terry Furey, and Iris Gonzalez for helpful discussions during the course of this project and Stephanie Doerner for helpful comments on the manuscript. ...doi:10.1093/nar/gkq1326 pmid:21355038 pmcid:PMC3130253 fatcat:k6cnohcmpffxnmwfqtpq2p7bym
Deletion of the CTRL2 Insulator in HSV-1 Results in the Decreased Expression of Genes Involved in Axonal Transport and Attenuates Reactivation In Vivo
Importantly, during reactivation, CTCF protein is evicted from the HSV-1 genome, especially from the CTRL2 insulator. ... CTCF insulators flank the LAT and IE regions of HSV-1 and during latency and maintain the integrity of transcriptional domains through a myriad of functions, including enhancer-blocking or barrier-insulator ... (A) The CTCFBDBS 2.0 program was used to identify the CTUS1B site as a putative CTCF-binding site. ...doi:10.3390/v14050909 pmid:35632655 pmcid:PMC9144644 fatcat:vqt75baef5drvl25y2bebaobya
Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer
We analyzed a number of distinguishing features at the HMB boundaries including transcription factor (TF) binding motifs, various epigenomic marks, and chromatin structural features. Result. ... We found that the classical promoter epigenomic mark, H3K4me3, is highly enriched at HMB boundaries, as are CTCF bound sites. HMB boundaries harbor distinct combinations of TF motifs. ... Acknowledgements Authors would like to thank Joyce Hasio, and Rukhsana Yeasmin for reading the manuscript and providing helpful comments. ...doi:10.1101/028803 fatcat:fi56i7k3kjcsrldvrfavq2elq4
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Here you have the information of people like you who bought the services and products of Hendren Hall (College) in Idaho area.
Right now this business has no ratings, which doesn't have to be bad by itself.
As you know, we do not usually stop to put opinions when these are good and we usually do it only if we've had a problem or incidence...
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Center for Economic Development
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Author: Kevin Schuler/Thursday, May 26, 2022/Categories: General, Social Services
With the month of June recognized nationally as Elder Abuse Awareness month, Niagara County is hosting two events for local senior citizens to help with abuse awareness and prevention, according to Darlene DiCarlo, Director of the county's Office for the Aging.
"Our office was awarded a $7,100 grant from Lifespan Rochester to support education and outreach about elder mistreatment during Elder Abuse Awareness Month and beyond," said DiCarlo. "We want our seniors to know that should they fall victim to abuse or some scam, they are not alone, they do not need to suffer in silence or feel embarrassed, and that there is help available to them."
The first event will be held at 12:30 p.m. on Thursday, June 2 at the Dale Association, 33 Ontario Street in Lockport. Kelly Zunner-Daniels from Lifespan will be speaking on elder abuse. The event will include free giveaways and a discussion on the resources for seniors from the Niagara County Office for the Aging; Alzheimer's Association; Center for Elder Law and Justice; Eastern Niagara Hospital; Niagara County Adult Protection Services; and the Niagara County Sheriff's Department.
The second event will be held at 12:30 p.m. on Tuesday, June 14 at the Lewiston Senior Center, 4361 River Road in Youngstown. Daniel Lyon from Lifespan will hosting "Name That Scam!", an interactive music driven presentation using songs from the 50's, 60's, and 70's to discuss the multitude of scams that target senior citizens.
For those who have any questions about these events, call the Office for the Aging at (716) 438-3030.
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