text: Fanbase Press has one of the great unheralded stories of the comic-book publishing world. Run by Los Angeles-based husband-and-wife team Bryant and Barbra Dillon, Fanbase Press has been putting out top-notch content for the past several years. The company's first two titles, Identity Thief and Something Animal, were both painterly explorations of dark psychosis. Since those releases, they've steadfastly sought out new works by talented writers and illustrators, with impressive results.


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LASU External System Moves to Clear all Outstanding Results
Lagos State University, LASU External System moves to clear all outstanding results.
…To Conduct Make-up Examinations for all Failed Courses/Missing Results.
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The Lagos State University has recently processed and graduated over 70%of the External System students, at both the Undergraduate and Postgraduate levels. The University has also embarked on the processing of the results of all other categories of students who may have legitimately completed their course of studies, but are yet to graduate owing to one reason or the other.
The University is therefore calling on all students of the Lagos State University External System who are yet to graduate to link up with the Directorate of the External System either in person or visit the designated website: http://studentservices.lasu.ng/lasues_makeup/ for registration.
The deadline for online registration for the examination is Friday June 16th 2017.
The External System has concluded arrangements to conduct make-up examinations for all courses yet to be passed by students or students with outstanding/missing results. The examinations have been slated to take place as follows:
- Saturday July 8th and 9th 2017: 100, 200 & – 300 Levels.
- Saturday July 15th and Sunday July 16th 2017: 400 & 500
Students are to note that all examinations will hold at the Main Campus, Ojo. They are to visit the online website: http://studentservices.lasu.ng/lasues_makeup for Registration of Courses, Applicable Fees and Examination Time Schedule.
Ademola Adekoya
Acting Head,
Centre for Information Press and Public Relations

subset: commoncrawl


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This guest post is by Sue Starfield who is an associate professor in the School of Education and the Director of the Learning Centre at UNSW Australia, as well as co-author with Brian Paltridge of Thesis and dissertation writing in a second language: A handbook for supervisors. Sue teaches courses in thesis writing for doctoral students and runs workshops for supervisors on ways they can help their students with their writing. If you like Sue's blog, you may also enjoy Susan Carter's recent post on the examiner perspective.
By Sue Starfield
Students and supervisors are often surprised when I talk to them about the research into what examiners look for in a PhD thesis. Almost apologetically, I'll explain that it's an area of growing interest. John Swales, the well-known applied linguist, coined the phrase 'occluded genres' to describe genres that are not publically and easily available. The PhD examination process and the examiners' reports that make our hearts sink or soar are typical examples of hidden or occluded genres. Fortunately, we now have some research that shines a light into what pleases or displeases examiners. This information is particularly important for students and their supervisors in countries like Australia where there is typically no oral defence or viva and examination is based solely on the written thesis. Hence the title of this blog post – the more we know about the examination (the end), the better equipped we are at the start.
One of the examiners interviewed in Mullins and Kiley's (2002: 386) now well-known study of PhD examiners explained: 'A PhD is a stepping stone into a research career. All you need to do is to demonstrate your capacity for independent, critical thinking. That's all you need to do. A PhD is three years of solid work, not a Nobel Prize'. A quick Google search of Nobel Prize winners suggests there is some truth in this – many are quite elderly by the time the earn the coveted award and it seems unlikely that they would have received it for their doctoral scholarship – although it may well have started them on the path to future glory[1]. So the key message here is 'get it done' – do it well but see the PhD as a time-limited stage in your career development.
What else do we learn from this study that interviewed experienced thesis examiners? Students and examiners tend to have radically different understandings of the purpose and functions of doctoral assessment. I regularly speak to students who are convinced they are going to fail. Experienced examiners on the other hand see their role as helping to make the thesis better! The research shows that the number of students who actually fail is extremely small. Many will be required to do revisions. From the examiner's perspective however, in the words of one of the examiners interviewed by Mullins and Kiley, doctoral assessment provides 'an opportunity for the students to be able to incorporate comments so that it [the thesis] sits on the library shelf and glows more brightly' (p. 383).
One of the key messages that can be distilled from the research is that first impressions count. Experienced examiners decide very early on whether the assessment of a thesis is likely to be 'hard work' or 'an enjoyable read' and their initial impression of the quality of the thesis is usually formed by the end of the second or third chapter – often by the end of the literature review. 'It is unusual that if someone does a poor job of the literature review that they will suddenly improve' said one experienced examiner. Bear in mind that chapters like the literature review that are often drafted early in the thesis process need to be kept updated and revised, often substantially, prior to submission.
We would all like our thesis to be in the enjoyable read category I'm sure. What can we do to get it there? Here are some of the things that a study of examiners' reports (Johnston 1997: 340-341) tells us:
- Examiners approach reading a thesis with an air of expectation and even enthusiasm, but this disappears if the thesis is not reader-friendly.
- General impression and overall presentation of the thesis seem particularly important to the examiners.
- The reader needs to be assisted through the use of summaries, logical sequencing, signposts and removal of excessive repetition.
- All readers require assistance to understand the work.
- They feel distracted and irritated by poorly presented work.
- They appreciate well-written, interesting and logically presented arguments
Mullins and Kiley note that 'sloppiness' is one of the most commonly used words to indicate a negative response to a thesis. Sloppy presentation seems to indicate to the examiner that the research might well be sloppy and they start reading the thesis with a more critical eye. Putting together a reader-friendly thesis takes time and effort. It may require several drafts. It involves getting feedback from readers including, but not limited to, the supervisors. I like to recommend a proof-reader or at least a reasonably literate friend. It has to be someone other than the author who, towards the end, will not see typos, grammatical errors, repetitions and illogicalities. Some may need an editor for more help with grammar and language. Whichever the route chosen, redrafting takes time. Count back from the submission date and build in the time needed for the final polishing – it always takes longer than anticipated. But as the research shows, the effort put in to craft a reader-friendly text will be worth it.
Chapter 11, 'Before you submit', in How to write a better thesis (Evans, Gruba & Zobel, 2011) has a great checklist of all the many things that need to be done to polish the final draft of the thesis. Print it out and use it.
Evans, D., Gruba, P. & Zobel, J. (2011). 3rd Ed. How to write a better thesis. Melbourne: University of Melbourne Press.
Johnston, S. (1997). Examining the examiners: An analysis of examiners' reports on doctoral theses. Studies in Higher Education, 22, 3: 333-347.
Mullins, G. & Kiley, M. (2002). 'It's a PhD, not a Nobel Prize': How experienced examiners assess research theses. Studies in Higher Education, 27: 369-386.
[1] John Nash, who died tragically in late May, was awarded a Nobel Prize with two other economists in 1994, based on work in his 1950, 28-page PhD dissertation.


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Do more for your career and your library through ALA Membership.
ALA Members have access to the best source for finding your first, next or best job through JobLIST and premier peer-to-peer resume and job interview skills building through the New Members Round Table. Become a better advocate for your library by learning ways to make the library more visible to your community and stake holders.
Take some time to check out the resources both below and those listed to the left, including:
Your fellow members are best kind of career consultants.
Just reach out whenever you needed some insight, ideas, or inspiration. Go to your "I do it every day" experts to stay up-to-date on the latest trends and developments in the library and information community. And best of all, ALA members are available year-round without consulting fees. Improve your visibility in the profession by participating in ALA, division and round table committees, and/or by writing or blogging for an ALA publication.
"Membership is an important part of my professional life. My work day is often spent doing other things than my job description said it would. But the connections I have among fellow members helps me find solutions and solve problems. I can get back on track and do my job more effectively, and efficiently, because of the resources I tap into among members." Mary Little, Director of Technical Services, Queens Borough (NY) Public Library
"ALA has had an incredible impact [on my career]. I am positive that some of my ability to move up in the profession can be credited to ALA." Rose Dawson, Director for the Alexandria (VA) Library
Advice for Career Development and Job Hunting Video


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Double Falsehood
Edited & adapted by Lewis Theobald (circa 1727)
Directed by Barrie Addenbrooke
In 1613 a play entitled "Cardenno" by William Shakespeare & John Fletcher was presented at the court of King James the First. It was next heard of as "The History of Cardenio" in an entry in the Stationery Register in 1653 again accredited to Shakespeare & Fletcher.
The play then disappears to resurface as "Double Falsehood" in 1727 as a premiere of a "lost play by William Shakespeare" presented by Lewis Theobald. The production was a success but subsequently it was felt that Theobald had over stated the extent of his discovery and that the piece was at best a collaboration and at worst a complete forgery by Theobald himself.
The play was lampooned, discredited and largely ignored in the 19th & 20th centuries. However in the 21st century most scholars agree that at least part of the text we have today belongs to the original Shakespeare & Fletcher work.
In 2010 The Arden Shakespeare pre-eminently valued editors of the Bard's work published Double Falsehood, as part of their third series. This decision has bought the play back into the public consciousness and reawakened many of the debates as to its authorship.
KDC are proud & privileged to be presenting the 21st Century London premiere of this fascinating and controversial play.
Double Falsehood takes its plot from the Cardenio part of Miguel de Cervantes 1605 work The History of Don Quixote. Translated into English in 1612 by Thomas Shelton this work became an inspiration for many contemporary playwrights including Beaumont, Wilkins & Middleton.
At the Union Theatre in Southwark running between 17- 21 August 2010. Tickets are now on sale are now open and with a limited run early booking is strongly advised. Box office 0207 261 9872.


text: Second Life, an online multiplayer game, has recently been targeted with self-replicating scripts, written with the Linden Scripting Language. Apparently there was a pretty bad attack last weekend, shutting down the game and leaving valid users still without script support. This "Grey Goo" attack was visible to the players of the game as it scattered revolving golden rings around. More from the official Linden Blog.


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The Jawahar Navodaya Vidyalaya Alumni Association (JANVAA) honored the APSCC founders for promoting 'green campus' strategies. The school's concept of a green campus advocates a model for global environmental sustainability where all the processes and operational functions of the campus are closely knit, providing educational and practical value to the institution and the surrounding environment.
The team helped introduce measures such as waste water treatment system, xeriscape, biogas generation, compost and vermicompost production, organic vegetable garden and organic herbal garden in an integrated manner. According to school authorities, since the inception of the green campus initiative (GCI), the school has bagged various awards at the national and State-level. Moreover, the school has hosted eminent professionals and scientists from US, Europe, Brazil and from various parts of India whose visits motivated students to embrace environmental sustainability.
Vinayathan, school Principal, said since adopting green campus initiatives, the environmental awareness among the students and their attitude towards conservation has significantly increased.
Link: http://www.thehindu.com/news/cities/puducherry/two-researchers-honoured-for-promoting-green-campus-strategies/article7994833.ece


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Comfort Suites Tolleson, Phoenix
Comfort Suites Tolleson8421 W. Mcdowell Road
This Tolleson hotel is within walking distance to Cricket Pavillion.6.5 miles to the Cardinals Stadium and 4 miles from the Phoenix International Raceway. Golf, shopping and restaurants nearby. Peoria Sports Complex 15 miles. Free wireless Internet access in all rooms and throughout the hotel. All Comfort Suites are smoke free. Must have 1 adult 21 years or older in each room.


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Long-term mammalian spermatogenesis requires proper development of spermatogonial stem cells (SSCs) that replenish the testis with germ cell progenitors during adult life. as compared to age-matched controls. While GFRα1+ spermatogonia are appropriately present CALNA2 as Asingle and Apaired in wild type testes TAF4b-deficient testes display an increased proportion of long and clustered chains of GFRα1+ cells. In the absence of TAF4b seminiferous tubules in the adult testis either lack germ cells altogether or are found to have missing generations of spermatogenic progenitor cells. Together these data show that TAF4b-deficient spermatogenic progenitor cells display a tendency for differentiation at the expense of self-renewal and a renewing pool of SSCs fail to establish during the crucial windows of SSC development. Keywords: TAF4b Spermatogonial Stem Cells Self-Renewal Spermatogenesis Meiosis Introduction Throughout most of an adult male lifespan unipotent stem cells in the testis called spermatogonial stem cells (SSCs) support long-term spermatogenesis. These SSCs undergo both self-renewing and differentiating divisions allowing for the production of millions of sperm each day. In mammals the process of germ cell development is complex and highly coordinated. Following specification in the proximal epiblast primordial germ cells (PGCs) migrate from your hindgut through the dorsal mesentery proliferate and colonize the nascent somatic gonad between embryonic days (E)8.5 and E13.5 [1-4]. Once inside the male gonad around E13.5 PGCs move to undifferentiated gonocytes that become enveloped in testicular cords using the somatic support cell precursors. In mice gonocytes proliferate until about E16 and become mitotically quiescent until postnatal time (P)4 if they migrate towards the basement membrane and job application proliferation to create differentiating spermatogonia and a inhabitants of SSCs which will support long-term spermatogenesis [5]. Much like all stem cell populations there's a sensitive stability between self-renewal and differentiation of SSCs Eribulin Mesylate that's highly governed and necessary for long-term spermatogenic differentiation. The indicators and molecular systems governing your choice of SSCs to renew or differentiate stay enigmatic. In the adult testes SSCs represent just 0.03% of most germ cells and so are difficult to tell apart from closely related and positioned differentiating spermatogonia [6]. Nevertheless within the last two decades many experimental advancements in steady SSC culturing and transplantation paradigms possess allowed us to explore Eribulin Mesylate many areas of SSC biology [7-12]. These advancements facilitated the breakthrough and characterization of many genes very important to SSC function such as transcription elements (Bcl6b Lhx1 Etv5 Identification4 and Plzf) translational regulators (Nanos2) extracellular signaling elements (GDNF GFRα1 and Ret) intracellular signaling elements (PI3K/AKT SFK) and recently microRNAs (miR-21)[3 12 Jointly morphological and molecular analyses determined Asingle (As) spermatogonia being Eribulin Mesylate a inhabitants of undifferentiated germ cells which contain SSCs. Latest identification from the transcription elements Pax7 and Identification4 marking two indie As subpopulations each formulated with solid SSC properties underscores the cell type and lineage heterogeneity that is available within As spermatogonia [21 22 During spermatogenesis As spermatogonia bring about 2 Apaired (Apr) and 4-16 Aaligned (Aal) spermatogonial chains through cell department and imperfect cytokinesis [23-27]. Aal spermatogonia synchronously differentiate in to the Eribulin Mesylate initial era of differentiating type spermatogonia that improvement through differentiating spermatogonial divisions accompanied by meiotic and post-meiotic differentiation to create older sperm. This cyclical procedure contains 12 (I-XII) following morphologically specific seminiferous epithelial levels [28]. Glial cell line-derived neurotrophic aspect (GDNF) signaling from Sertoli cells promotes proliferation of undifferentiated spermatogonia and can be necessary for SSC maintenance [29-32]. A subset of SSC-containing undifferentiated As and Apr spermatogonia exhibit the GPI-anchored cell surface area GDNF receptor GFRα1.
Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are byproducts of combustion and photo-oxidation
Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are byproducts of combustion and photo-oxidation of parent PAHs. XAN exposures increased expression of several oxidative stress related genes and decreased oxygen consumption rate (OCR), a measurement of mitochondrial respiration. Comprehensive characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms. mortality and lower intelligence (Perera et al., 1998; Dejmek et al., 1999; Perera et al., 1999; Dejmek et al., 2000; Perera et al., 2006; Perera et al., 2009; Wu et al., 2010). Despite the more than two decades of intensive study devoted to parent PAHs, they are only part of the hazard spectrum from PAH contamination. Oxygenated PAHs (OPAHs) are transformation products of PAHs, toxic to humans and the environment and, until recently, a largely neglected class of contaminants at PAH contaminated sites (Lundstedt et al., 2007). OPAHs are ketone and quinone substituted PAHs deriving from the same sources of incomplete combustion and showing relatively high environmental mobility and persistence (Zielinska et al., 2004; Lundstedt et al., 2007; Simoneit et al., 2007; Medeiros and Simoneit, 2008; Layshock et al., 2010; Shen et al., 2011a; Shen et al., 2011b). It has been anticipated, though not yet clearly shown, that OPAH contamination may actually increase at sites remediated by methods that promote PAH degradation (Lundstedt et al., 2007) making them a potentially greater health hazard than the parent contamination. OPAHs are also secondarily produced through photo-oxidation reactions of PAHs with atmospheric oxidants, including ozone and nitrogen oxides (Yu, 2002; Vione Vargatef et al., 2004; Lundstedt et al., 2007; Wang et al., 2007). OPAHs are found on diesel soot particles, wood smoke Vargatef particles and gasoline engine soot (Rogge et al., 1993; Rogge et al., 1997; Mazurek, 2002; Layshock et al., 2010; Ding et al., 2012) and show an overall affinity for fine PM2.5 particle-association, raising their hazard potential because of the proclivity of PM2.5 to travel deep into the lung (Shen et al., 2011a). Diesel exhaust particles and associated PAH quinones and other oxygenated derivatives are involved in the formation of reactive oxygen species (ROS), which can result in inflammatory responses Rabbit Polyclonal to SLC39A1. and are suspected to be a major driver of pulmonary oxidative stress and consequent cardiovascular disease in urban areas (Chung et al., 2006; Nemmar et al., 2011; Channell et al., 2012). Airborne OPAH concentrations have been highly correlated with reactive oxygen species (ROS) formation, suggesting that oxidative stress is one of the toxicity mechanisms for aerosol-induced human health effects (Sklorz et al., 2007). PAHs and OPAHs in ambient particulate matter samples increased oxygen free radical formation, as measured by electron spin resonance, and some of these OPAHs were directly involved in ROS generation (Sklorz et al., 2007). Oxidative stress was a component of the developmental toxicity induced by the OPAHs – and -naphthoflavone in zebrafish (Timme-Laragy et al., 2009). Some PAHs have demonstrated carcinogenic potential (Okona-Mensah et al., 2005) and contributed to the mutagenic activity of ambient aerosols (Pedersen et al., 2004; Pedersen et al., 2005; Avellaneda et al., 2011; Kim et al., 2011). The OPAH and nitro-PAH fractions of air samples from Beijing, China were Vargatef shown to be twice as mutagenic as the parent PAH fraction, though no further specification of the fractions was made (Wang et al., 2011). OPAH derivatives have been reported as highly mutagenic compounds in a study of human-cell mutagens in respirable airborne particles from the northeastern United States (Pedersen et al., 2004). Numerous and toxic effects of PAH quinones have been described, but little is known about the developmental effects of OPAH exposure. Inference can be drawn from the known toxicology of napthoquinones, which bind to biomacromolecules; and quinones.
Graves' disease after the initiation of highly dynamic antiretroviral therapy (HAART)
Graves' disease after the initiation of highly dynamic antiretroviral therapy (HAART) using HIV-1-infected individuals continues to be referred to as an defense reconstitution inflammatory symptoms (IRIS). who had been began on HAART therapy. 1 Launch GDC-0879 The start of the GDC-0879 extremely energetic antiretroviral therapy (HAART) period around 1995 signaled a paradigm change in the scientific outcome of sufferers contaminated with HIV as shown by a GDC-0879 substantial improvement in general survival [1]. Sufferers with HIV an infection who are on HAART obtain recovery of previously affected immune system function leading to reduced mortality and morbidity from opportunistic attacks [2]. Nevertheless a minority of sufferers might knowledge a paradoxical scientific drop due to immune system restitution [2]. This phenomenon happens by virtue of repair of the capacity to mount an inflammatory response against both infectious and noninfectious antigens [3] therefore the term immune system reconstitution inflammatory symptoms (IRIS). IRIS takes place most commonly due to reactivation of attacks such as complicated or cytomegalovirus and will occur between a couple weeks and several a few months after initiating HAART matching with Compact disc4 positive storage cell repopulation [4]. The introduction of a number of autoimmune illnesses continues to be reported in sufferers contaminated with HIV. Autoimmunity might occur because of the loss of immune system competence but could also show up after commencement of HAART [5]. Certainly autoimmunity because of immune system reconstitution continues to be named an unfavorable event in HIV-1-positive people. Graves' disease caused by immune system restoration has already established relatively recent identification and might end up being viewed because of organ-specific autoimmunity through the late amount of T-cell repopulation particularly of Compact disc4 positive na?ve cells [6]. We survey four situations of Grave's IRIS inside our practice. The complete demographics and HIV-related history is summarized in Table 1 and thyroid-related management and workup in Table 2. Desk 1 Demographic immunological and virological data for the entire instances defined. Desk 2 Thyroid workup and administration (Foot4: free of charge T4 TSH: thyroid stimulating hormone TPO-Ab: thyroid peroxidase antibody TBG-Ab: thyroglobulin antibody PTU: propylthiouracil). Case 1 -A 34-year-old BLACK male using a Compact disc4 T-cell count number of 59?cells/μL and HIV RNA level >750 0 was started on stavudine abacavir lamivudine and efavirenz. Forty-four months later he offered weight loss alopecia diarrhea palpitations lid thyromegaly and lag. Thyroid function lab tests revealed elevated free of charge T4 and thyroid peroxidase antibody (TPO-Ab) amounts with undetectable thyroid rousing hormone (TSH) amounts. A thyroid ultrasound uncovered multinodular adjustments with diffuse enhancement from the gland. He was treated with methimazole and We-131 radioablation with comprehensive quality of symptoms ultimately. GDC-0879 Case 2 -A 42-year-old BLACK male using a nadir Compact disc4 T-cell count number of 89?cells/μL and HIV RNA degree of 205?copies/mL initiated a routine of lamivudine zidovudine and efavirenz with good response. Fifty-three months later on he presented with weight loss tremor exophthalmos and an enlarged thyroid gland. Thyroid function checks were consistent with hyperthyroidism with an enlarged thyroid gland on ultrasound. Thyroid scintigraphy shown the elevated uptake of I-123. He was handled successfully with methimazole and atenolol. Case 3 -A 39-year-old African male presented with a CD4 T-cell count of 59?cells/μL and an undetectable HIV RNA level. He was treated with tenofovir/emtricitabine/efavirenz. Within thirty-one weeks he presented with GDC-0879 palpitations tremors fatigue and excess weight loss. The thyroid gland was enlarged. Thyroid function checks exposed an undetectable TSH with high free T4 and antithyroglobulin antibodies. Graves' disease was handled with metoprolol and propylthiouracil with total medical response. Rabbit Polyclonal to FXR2. Case 4 -A 43-year-old African GDC-0879 American female had an initial CD4 T-cell count of 29?cells/μL and HIV RNA level of 252 984 She began tenofovir/emtricitabine/efavirenz and tolerated HAART well. Nineteen weeks she experienced tremor weight loss and diarrhea with reduced urge for food later on. Her thyroid gland was enlarged and pulsatile and she acquired exophthalmos using a.
(4) ascribed every racial category select personality characteristics skills and abilities
(4) ascribed every racial category select personality characteristics skills and abilities providing a medical foundation for racism (5). OMB with only two major groups (Hispanic/non-Hispanic) with Hispanic referring to people who determine their or their ancestors' history nationality lineage or country of birth before arriving in the United States as Hispanic Latino or Spanish no matter race (6). Of course the anthropologic and commonplace understandings of ethnicity involve A-674563 many more groups and ways of categorizing; yet how best to define and measure the ways that ethnic factors function socially in the United States remains underexamined in the health literature. Most interpersonal science meanings of ethnicity describe what might be referred to as an attributional dimensions describing the sociocultural characteristics ((8) in this problem of the (8) examined the prevalence of CKD defined by a Chronic Kidney Disease Epidemiology Collaboration eGFR (eGFRcreat-cyst) <60 ml/min per 1.73 m2 or albuminuria among over 15 0 Hispanic/Latinos of Cuban Dominican Mexican Puerto A-674563 Rican Central American and South American backgrounds in the HCHS/SOL-groups whose average length of time in the United States immigration status economic status reasons for migrating standard migration experience and racial composition diverse widely. Ricardo (8) found out an overall prevalence rate of 13.7% similar to the overall estimated CKD prevalence of 13.6% in the United States as reported in the 2007-2012 National Health and Nourishment Examination A-674563 Survey (NHANES) (14). The prevalence assorted greatly across individuals of different Hispanic/Latino backgrounds reinforcing the part of ethnic diversity on health profiles of different A-674563 Hispanic/Latino areas and highlighting how such info may be helpful for community specific CKD prevention early treatment strategies and general public health messaging. Among the different Hispanic/Latino groups within the HCHS/SOL individuals of South American background in particular experienced a markedly lower A-674563 prevalence of CKD whereas individuals of Puerto Rican background and Hispanic additional had the highest CKD prevalence rates. Interestingly the HCHS/SOL Hispanic/Latino ladies had a lower prevalence Rabbit Polyclonal to EGR2. of CKD than did the males which is the reverse of what was found in non-Hispanic whites in NHANES (8). The transition from CKD to ESRD was not formally assessed with this study but is also known to be multifactorial. A comparison of Hispanic/Latino participants in the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic CRIC studies with non-Hispanic CRIC individuals discovered that Hispanics/Latinos with CKD experienced disproportionately from lower socioeconomic position higher prices of diabetes mellitus poor BP control lower prices of treatment with inhibitors from the renin-angiotensin program and more serious CKD adding to their elevated odds of developing ESRD weighed against non-Hispanics (15). Apart from traditional scientific risk elements place of delivery and acculturation may play essential assignments in the deviation of CKD prevalence prices among different Hispanic/Latino groupings. In this research Ricardo (8) discovered A-674563 that birth in america was connected with a two-fold altered threat of eGFRcreat-cyst<60 ml/min per 1.73 m2 recommending a significant likely function for adoption of Western life style or lack of resilience elements that are fortified in countries of origin. Areas of acculturation and related elements such as for example literacy public support health facilities of the united states of origin distinctions in retention/reduction of cultural procedures (diet plan and public/family framework) and/or migration-related injury were not analyzed but have already been reported by Lora (16) to alter between Hispanics/Latinos of different roots in america plus they may donate to distinctions in CKD prevalence and development. Also select hereditary predispositions may can be found specifically in Hispanics/Latinos of Puerto Rican Dominican and various other Caribbean parental ancestry with non-diabetic ESRD who had been reported to possess prevalence prices of two apo L 1 (APOL1) risk alleles up to 20% (17). APOL1 is normally a solid predictor for kidney disease. Provided the suggested two-hit hypothesis where in fact the APOL1 risk alleles exhibit CKD development in the current presence of another inciting condition or event (18) the high prices of CKD risk elements.
Background Epidemiologic evidence suggests that nonsteroidal anti-inflammatory medications (NSAIDs) delay starting
Background Epidemiologic evidence suggests that nonsteroidal anti-inflammatory medications (NSAIDs) delay starting point of Alzheimer's dementia (Advertisement) but randomized studies show no reap the benefits of NSAIDs in symptomatic Advertisement. Overall NSAID-related damage was no more evident but supplementary analyses demonstrated that elevated risk remained significant in the initial 2.5 many years of observations especially in 54 persons enrolled with Cognitive Impairment – No Dementia (CIND). These same analyses demonstrated later decrease in Advertisement occurrence among asymptomatic enrollees provided naproxen. CSF biomarker assays recommended that the last mentioned result reflected decreased Alzheimer-type neurodegeneration. Conclusions These data PKI-587 recommend a revision of the initial ADAPT hypothesis that NSAIDs decrease Advertisement risk hence: NSAIDs have an adverse effect in later stages of AD pathogenesis while asymptomatic individuals treated with standard NSAIDs like naproxen experience reduced AD incidence but only after 2 – 3 years. Treatment effects differ at various stages of disease So. This PKI-587 hypothesis is normally in keeping with data from both studies and epidemiological research. 1 History As populations age group Alzheimer's dementia (Advertisement) presents a massive threat to Rabbit polyclonal to FBXW8. community wellness [1]. The pathogenesis of Advertisement contains pre-symptomatic and prodromal levels that jointly last ten years or even more before onset of dementia [2]. Useful neuroimaging data claim that pre-symptomatic Advertisement is seen as a adjustments in synaptic function [3] perhaps induced by oligomers from the Alzheimer amyloid peptide Aβ [4]. The familiar pathological hallmarks of Advertisement – senile plaques neurofibrillary tangles and neuronal degeneration – become preponderant afterwards typically in the prodromal and dementia levels [5 6 This progression in Advertisement pathogenesis shows that interventions can vary greatly in their results at different levels of disease. Such a mixed response to treatment continues to be observed for instance in the transgenic R1.40 mouse style of AD where in fact the nonsteroidal anti-inflammatory medications (NSAIDs) ibuprofen and naproxen suppress brand-new neuronal ectopic cell cycle events induced by Aβ oligomers but neglect to reverse existing events [7]. In lots of observational research users of NSAIDs have already been found to build up Advertisement with reduced regularity but there's been no such association with contact with these drugs quickly before dementia starting point [8 9 Many randomized studies have evaluated the feasible neuroprotection recommended by these observational research results. Using the single exception described here those trials possess all been conducted in symptomatic individuals however. Results have already been unsatisfactory. Studies of NSAIDs in sufferers with set up dementia demonstrated no mitigation of PKI-587 indicator development [10 11 Also in sufferers with milder cognitive symptoms occurrence of Advertisement was elevated in those that received the cyclooxygenase-2- (COX-2)-selective NSAID rofecoxib [12]. A synthesis from the lab observational and trial data as a result shows that NSAIDs may provoke contrasting results at different phases of AD pathogenesis with neutral or adverse influence on the risk of dementia onset in people with symptoms but possible protection against onset in those with healthier brains. 2 Methods 2.1 Approach We prolonged the observation period PKI-587 of the previously reported randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT) designed to test the hypothesis that sustained use of naproxen or celecoxib would reduce incidence of AD in healthy elders [13]. Issues about safety experienced led to termination of the ADAPT treatments late in 2004 after an PKI-587 average 24 (s.d. 11) weeks of treatment task [13 14 At that point an analysis of 32 event cases of AD (the trial's main PKI-587 outcome) experienced suggested a possible increase in risk of dementia with either NSAID as reflected by a risk percentage placebo (HR) of 1·99 (95% CI 0·80 – 4·97; = 0·06) for naproxen [13]. Following a basic principle of intention-to-treat (ITT) the primary analysis then included seven individuals who had been randomized before we learned that they had dementia at baseline. Because these seven were not at risk of event dementia we also excluded them in a secondary analysis planned prior to completion of data collection and.
Acclimation of cyanobacteria to environmental changes includes main adjustments in the
Acclimation of cyanobacteria to environmental changes includes main adjustments in the gene appearance patterns partly orchestrated with the substitute of a specific σ subunit with another in the RNA polymerase holoenzyme. the Δstress which includes SigE as the just useful group 2 σ aspect did not develop quicker under mixotrophic than under autotrophic circumstances. The SigB and SigD factors were important Tubacin in low-temperature acclimation under diurnal light rhythm especially. The Δstrains had been delicate to high-light-induced photoinhibition indicating a central function from the SigB element in high-light tolerance. Furthermore the Δstress (SigD may be the just useful group 2 σ aspect) were locked in the high-fluorescence condition (condition 1) and grew gradually in blue however not in orange or white light. Our outcomes suggest that top features of the triple inactivation strains could be grouped as (i) immediate consequences of the inactivation of a particular σ element(s) and (ii) effects resulting from the higher probability that the remaining group 2 σ factors associate with the RNA polymerase core. Cyanobacteria are eubacteria capable of oxygen-producing photosynthesis and the chloroplasts of vegetation and algae developed from cyanobacteria (26). sp. strain PCC 6803 (here is especially popular as genetic manipulation of this naturally competent strain is easy and the cells can be cultivated under autotrophic mixotrophic photoheterotrophic or light-activated heterotrophic growth conditions (1 38 Light is IL5RA probably the key environmental factors and cyanobacteria are able to respond to both light quality and light amount. Cyanobacteria acclimate to light intensity changes by modifying the expression of many genes including those coding for components of the photosynthetic apparatus (8-10). In addition the orange carotenoid protein (OCP) (39 40 the IsiA pigment protein complex (7 41 high-light-induced proteins (6 36 and the efficient photosystem II (PSII) repair cycle (33 34 keep Tubacin the photosynthetic machinery functional under high-light conditions. The most dramatic light quality effect is seen in those cyanobacteria that perform complementary chromatic adaptation (15 17 They change color from blue-green to brick red when the cells change phycocyanin to phycoerythrin in phycobilisome antennae upon transfer from red light to green light (15 17 is not able to perform complementary chromatic adaptation but it can balance energy distribution between photosystem I (PSI) and PSII according to the light quality (14 35 Phycobilisomes which function as major light-harvesting antennae of PSII efficiently collect Tubacin orange light while the chlorophyll (Chl) antennae of PSI harvest mainly blue and red light. State transitions balance energy distribution between the photosystems according to the light quality: illumination with orange PSII light leads to state 2 in which energy is transferred more efficiently to PSI and treatment with PSI light (blue light) leads to compensatory energy flow to PSII (state 1) (14 35 Acclimation to different environmental conditions is based on adjustments of gene expression. The promoter-recognizing σ subunit of the RNA polymerase (RNAP) holoenzyme has a central role in this process. Tubacin Different σ factors compete for a limited number of catalytically energetic RNA polymerase cores and switching between different σ elements is a significant determinant of the entire gene expression design in eubacteria (19 21 In cyanobacteria all Tubacin σ elements participate in the σ70 family members which is split into three subgroups (18 22 The group 1 σ element is vital for cell viability group 2 σ elements are very like the group 1 σ element but are non-essential and group 3 σ elements differ substantially from organizations 1 and 2. Cyanobacteria typically code for a number of group 2 σ elements and recent research possess revealed that group 2 σ elements play crucial tasks in acclimation to suboptimal circumstances (for an assessment see guide 22). encodes four group 2 σ elements. Studies with solitary inactivation strains possess revealed how the SigB (13 28 30 31 and SigC (5 32 elements get excited about acclimation to high-temperature tension. The SigD element alongside the SigB and SigE elements is involved with light rules both in light-dark transitions and upon light strength adjustments (12 13 24 25 29 42 The SigE element has a part in sugar rate of metabolism and is necessary for light-activated heterotrophic development (23). All mixed group 2 σ elements affect the acclimation of cells to osmotic.


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Snapfulfil has lifted the Technology Partnership of the Year trophy at the Direct Commerce Association's (DCA) annual awards, in partnership with The Cotswold Company.
Running alongside the established DCA Supplier of the Year Awards, the Partnership of the Year Awards were launched this year to allow companies to showcase how their solutions are helping eCommerce retailers to be more successful. The awards were presented at the Direct Commerce Association President's Dinner at The Lancaster, London on 22nd October.
Snapfulfil's entry highlighted the significant benefits its SaaS warehouse management system has delivered to The Cotswold Company. As a direct result of implementing Snapfulfil, the fast-growing online furniture retailer is able to handle double the volume with fewer people and has successfully insourced the warehouse operation.
Snapfulfil Managing Director, Tony Dobson, says: "Snapfulfil is helping an increasing number of fast-growing eCommerce businesses to streamline their fulfilment operations and The Cotswold Company is a superb example. Winning the DCA's Technology Partnership of the Year award recognises our shared success story and how a best-in-breed WMS like Snapfulfil can drive major improvements in a short space of time."


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Now here's an all-new way to enjoy GarageBand on your iPad. It can get a bit boring after just tapping along to the beat with your fingers and using real drumsticks wouldn't really be wise, unless you're set on destroying that beautiful piece of Apple hardware.
But the people behind Pix & Stix are bent on changing that with their nifty old drumsticks with soft electroconducive rubber tips.
They come in basic black and in two equally yummy colors too: vibrant blue and bright yellow. The Pix & Stix are also weighted to give you the best drumming experience while allowing you to grip it comfortably. Each set also comes with a moulded pick with a color that matches your drumsticks for easy and realistic strumming.
It might seem extraneous, going through all this trouble just to play GarageBand in a more realistic way. But I do believe the Pix & Stix can add a whole lot to the overall gaming experience in the end. And just for AUD 14.95 (~$16 USD), too.


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The Fast and Frugal Ways to Redecorate Your Home
When it comes to our home, we all want it to be comfortable and inviting to those who take the time to visit us, as well as one we can be proud to show off. If your home seems a little dreary or feels a little outdated, you can make some changes that will brighten it up and leave you with a feeling that you've just given your home a much-needed facelift. The following are some fast and frugal ways to redecorate your home.
Painting Tips
One of the main ways people tend to redecorate their homes is by painting. This is an inexpensive method to create a whole new look and on top of that, you can do it by yourself. When painting your rooms, it is important to remember that you should match the shade to the colors in your furniture, unless you plan on new furnishings, as well. If painting your room is not something you want to do, consider adding a wall border or choosing a wallpaper to brighten up your room. These are all inexpensive ways you can change the decor of your home.
New Curtains
Another fast and frugal way to redecorate any room is with new curtains. Whether you are aiming for the sleek look or the country look, you'll find a variety of styles and colors to choose from. Cafe curtains are a great way to let some light into your kitchen and for a new look in your living room, try something bright and cheerful. If you have the skills to sew, try new looks for the cost of fabric. If you are crafty, you can even try your hand at a new cover for your sofa to match your curtains. For those that do not have sewing skills, you'll be able to find one-size-fits-all sofa covers in almost any department or home decorating store.
Candles and Candle Holders
One of the most enjoyable ways for you to change or add to your decor is with the use of candles and candleholders. Candles can be purchased in a variety of scents and colors that will add to the aroma, as well as the style of your home. Place them on tables and windowsills, as well as on the mantel and hearth. The candle holders you purchase should go with the decor of your home and may include many different styles, the most popular of which are metal candle holders. From candle holders made of stone such as an amethyst cluster to a work of art made from metal, they are an inexpensive and subtle way to change the atmosphere in your home.
To change or improve your home decor, you do not have to spend a lot of time or money. From a simple paint job to adding candles and candleholders, you can create a warm and inviting atmosphere in which to live. If you are tired of having the same old look in your home, consider making small changes to your home a little at a time. When you redecorate, it does not have to be done in one day. By slowly creating the atmosphere you desire, you'll be able to ensure that it will be done in the decor you really desire.


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Over the weekend politicians tried their best to campaign. One of the candidates for the MEP came to Częstochowa… two short stories about some weird incidents taking place in Poland. Let me assure you, not all is rosy, but also not all is black. The next winter will be coming only in eight months.
Saturday, 30 March 2019, Częstochowa. 1500 nationalists take part in their annual pilgrimage to the Jasna Góra shrine, a Catholic monastery in the southern Polish city. Historically it is one of the most important religious sites in the country. In recent years it became a major site for the Polish nationalists.
On Saturday the usual offensive words are used against the cosmopolitan, multinational, rainbow, colourful, open Poland. "There is a civilizational assault on Poland. Under the sign of the rainbow flag, there is an attempt to steal the values such as truth and love", says a Catholic priest Henryk Grządko, according to oko.press. The participants shout their regular slogans "Great Catholic Poland" or "God, Honour, Fatherland".
Among the participants is the candidate of the far-right for the European Parliament Kaja Godek. She was clearly moved and tweeted this photo…
Sunday, 31 March 2019. Another priest of the Catholic Church organises a local book burning. Your regular after Church activity, right? Apparently the local priest has been collecting books from his parish for a few days. The targeted books and other items are all those which "bring the power of evil". TVN24 has the full story.
Among the burned books are the Harry Potter saga, other fantasy books, books about Hinduism and amulets: a mask, a figurine of an elephant. Also targetted are an Hello Kitty umbrella and paintings.
The weekend is over. Reactions to those backward-looking incidents come in. The book burning is not welcomed anywhere. Even the PiS government is critical. Jarosław Gowin, who serves as the vice-prime minister and minister for science tweeted "censorship or book burning cannot be the response to wrong books; write the good books". The popularity of the move, however, transcends borders. The BBC wrote about the book burning.
No specific reactions to the far-right march in Częstochowa, except for left wing commentators denouncing the activity as in fact anti-Catholic. It seems the far right becomes a new norm.
Et alors?
Law and Justice is heavily criticised by the far right as in fact pro-gay, pro-Jewish and pro-abortion party. Is it? Just last month the PiS leader turnout out to be a homophobe? Yet the far-right attacks the ruling party for being "soft". See this tweet as an example "denouncing" vice-prime minister Gowin who allegedly said "Poland is the fatherland of two nations. It is the fatherland of the Polish and Jewish nations" and the Konfederacja (Poland's far-right's party's current name) responds: "Mr Vice-PM, Poland is the fatherland of the Polish nation, NO OTHER".
The PiS reaction is precious. Wait, what reaction? PiS reaction to the far right is next to non-existent. Only once the PiS minister for interior and the party candidate in EP elections Joachim Brudziński apologised for his slow reaction to the far right activity (January).
The PiS proper reaction is different. Back in December a nationalist was appointed a minister in the Mateusz Morawiecki government. It is April and the nationalist is still a sitting minister in the Polish government. Just these last days the nationalist Mr Andruszkiewicz had to defend himself against even more nationalistic comments. The issue? His engagement was in Rome, not in Poland. Andruszkiewicz: "it was a pilgrimage to the Vatican and the grave of St Peter" so he and his fiancee had an important private moment in the eternal city. Congratulations.
There are many PiS politicians who are not racist, anti-Semitic, anti-LGBT or anti-women. It is a shame they hardly ever speak up. Instead of defending their virtues and values, the PiS politicians chose to attack, even to vocally assault the opposition, the liberal media and the various socio-economic groups who do not vote PiS.
I don't even want to ask when was the last time someone burned books in Europe.
I don't want to know what kind of gesture the Polish far right is making during their swearing in ceremony.
Welcome to the 2019 Middle Ages. European elections are in less than 2 months. Thank God the real electoral issue is the teachers' strike scheduled for 8 April.
Today, 2 April 2019 is the 14th anniversary of the death of John Paul II aka Karol Wojtyła, who was the pope of the Catholic Church 1978-2005 and remains an important figure of the Polish Catholic Church. Pity the Church in Poland is less and less Catholic (=common) and more and more Polish (=nationalistic).


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Posted on 2nd April 2019
Dear Parent,
Student Leadership
It was a difficult choice deciding upon the six students to become the Senior Prefect Team! I am pleased to announce the six students that have been selected after a two stage process. I am immensely impressed with the 24 students, just under a third of Year 12, who put their names forward. And it was good to see that they all had welcomed the team's restructuring to have a senior prefect team that was free from gender restrictions. Moreover, we have given each student a specific role to 'champion'. The roles include mental health, student voice and e-safety. The team are as follows (in alphabetical order):
Head Girl: Anna Carter
Head Boy: Will Gale
Senior Prefect Team: Jyothi Cross
Francesca Hannath
Aimee Mason-Lynskey
Jack Swain
As well as Senior Prefect Team, today, Year 12 students have selected their house officials for the next year. My congratulations to them on their achievement. I wish them success as they work with their respective Heads of House (Mrs Cooke, Miss Dales and Mr Markham) as they look to provide students with a range of fun, competitive activities that help to develop relationships between year groups. As ever, Mr McTernan does a first class job to keep everything on the road.
|Harry Wilkins,
Ellie Shepherd
|Alice Ward,
Toby Hibbert
|Ewan Martin,
Lili Gregory
|Lucy Cullen,
Matthew Savage
|Emily Barratt,
Michael Durham
|Lizzie Dee
Oliver Levitt-Allen
|Performing Arts
|Libby Tasker,
Oliver Sullivan,
|Maya McCann
Henry Montgomery
|Emily Oldridge
Josh Hughes
Young Enterprise
Our two Young Enterprise teams were in Lincoln on Wednesday night representing the School at the Young Enterprise Lincolnshire Final. Signa won best presentation and Hey Happy best customer service. Thanks to Mr McTernan, Mrs Hughes and Mrs McKinsley for not just taking them but supporting and guiding them through the process. Signa, who made Tote bags, were: Xander Ashley-Turner, Ben Dawson, James Bushby, Kate Jennings and Toby Hibbert. Hey Happy, who produced a mental well being book for primary school students and held stress ball workshops, were: Tyler Pickerden, Jennifer Ketley,Guy Lyons, Tom Baslington, Nathan Sharpe, Eoin McHale, Fadwa Al-Moasseb, Oliver Sullivan,Anna Carter and Christopher Cook.
Year 11 Football
Commiserations to the Under 16 Football team who were beaten by their nemesis Carre's Grammar School in the County Cup Final in Lincoln on Wednesday. In a closely fought game, the team lost 2-1. Carre's were finalists in the national tournament this year so it was a respectable result. I, along with several parents watched from the touchline. I was impressed with the boys' sportsmanship, respect and the support that they gave their team mates. These are qualities that I aspire to see as the norm at School. It is also worth noting that we're reaching the end of the season for several School teams and for some students in Year 11 in particular, it might be the last time that they represent the School in this context. I want to thank them first of all for their commitment to School and secondly to acknowledge the way in which they have been proud to wear the shirt, and have given their best. I have also been impressed with the way in which Sixth Form students have supported fixtures. This week, we had a large volume of girls' fixtures against Winterton (results below).Emily Barratt and Verbena Sajjad assisted with the netball. Ellie Shepherd helped with the hockey.
I recommend you take a look at the Target careers Futurewise website. (Enter that search into Google). They are holding a range of workshops in London over the Easter holiday for students considering careers in Engineering, Finance, Media, Law, Physics & Aerospace. (Please note that I am not endorsing this service, simply making you aware that there are opportunities to explore for students.)
Well done to Josh Knapton (Y11) who, as well as playing at junior county level for Lincolnshire, is also playing for Scunthorpe 1st team.
End of term
We finish for the Easter holidays on Friday 5 April, and like other Caistor schools, we finish at 2.30pm. All service bus will depart earlier except for the LCC/Dents bus service which runs through Osgodby, Middle Rasen and Market Rasen. This service bus' timetable does not change on the last day of term. We can accommodate students on that bus service in School until the normal finish time of 3.45pm. Please inform the office if you wish to take up this offer.
Yours sincerely
Alistair Hopkins


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Coffee culture in Hong Kong is indisputably growing fast, but it's growing even more rapidly on me. A few months back, I wrote about the 4 best cappuccinos in Hong Kong, but I've definitely discovered many more excellent coffee spots since then that'd make it on such list, like Bakery Cafe (Central), Five Coffee Company (Sai Kung) and Espresso Alchemy (Tsim Sha Tsui).
Interestingly though, coffee and food has started to develop into two segregated activities for me, as in, I'd go for lunch then move elsewhere for a cup of coffee. Great coffee and great food just don't get housed under the same roof in this city. So it was genuinely a shocker to discover Espresso Alchemy, possibly just the one exception to that rule, which honestly does a top notch job at the two.
Piccolo Latte *must order*
I first discovered and fell in love with the piccolo latte when I went to Roast (in Bangkok) about 2 years ago but since then haven't really seen it on menus much in Hong Kong, and when I do, they're usually a let down. Turns out there's quite a bit of skill that goes into making a piccolo latte, and that's why a lot of places don't serve it, or don't serve a good one.
The piccolo latte here is extremely smooth, creamy and easy on the tastebuds. By default (of the coffee blend used), there's a unique hint of floral aftertaste. Admittedly, this was a little weird at first, but was a taste that grew on me. If you prefer a more usual coffee-like taste, request the house blend for your piccolo latte. This one has a slight cocoa aftertaste, resembling the more typical cup of coffee.
Honey Earl Grey Latte
I'm definitely a "coffee person" and I've always been skeptical about tea lattes. I've had a few before and they often just taste excessively artificially sweet, with almost no tea taste to it. Here, they sugar this drink up with honey which I find much more approvable (than syrup) and the drink still retains a strong earl grey tea flavour. Although the piccolo latte was amazing, the earl grey latte was an even bigger surprise.
Unique Salad Dressing using Anchovies
A set comes with either salad or soup (add HK$10) and though the salad seemed to be the boring choice, the taste was not ordinary at all. Apart from the extremely crisp fresh leaves, the salad dressing was unique and super tasty. I thought it was cheesy but turns out it's made with a bit of anchovies. Ok that may put off some of you but seriously trust me and give it a try.
So I recommended this place to my sister shortly after tasting it myself and she said the soup was really good too. So I don't think you can go wrong with either choice anyway.
Pesto Cream Sauce Pasta *must order*
Excellent coffee is kind of expected for a decent coffee shop, but they actually have a legit kitchen at their Tsim Sha Tsui branch, rather than just the toaster, microwave and pan that most coffee shops are equipped with. Having sampled two of their main dishes, they make food better than most restaurants out there at about half the price!
The pesto cream sauce was possibly one of the biggest highlights of our meal here. The sauce was entirely homemade with none of that oily jarred pesto sauce that most restaurants in Hong Kong use. It was perfectly herby and slightly creamy, mixed with very al dente pasta. The tiger prawn was not extraordinary, but the sauce was really the star of the dish anyway. Plus, a meal here cost HK$88 (with salad and coffee and no service charge), so I hardly expected them to dish out fresh caught prawns to top my pasta.
Apart from the pesto pasta, they also do a really good lasagne with bechamel sauce. I also heard their Australian steak is bang for buck for only HK$118!
We ended our meal with a pretty decent tiramisu. While this was not exactly the best tiramisu, they did a really decent job at a light refreshing dessert that most importantly tasted very fresh.
Perfect for casual catch-ups over coffee and/or lunch
On many levels, this place is a perfect spot for casual catch up sessions. You can do it over just (excellent) coffee and your non-coffee friend can be kept happy with a range of delicious tea lattes. You can order a proper restaurant-quality meal. It's also located pretty conveniently in WK Square, Tsim Sha Tsui, the entrance of which is next to Chung King Mansion and very close to the MTR.
This must be my best value-for-money discovery in a long time.
Espresso Alchemy
Basement, WK square,
Nathan rd
Tsim Sha Tsui
Spend per person: HK$90-130 (with their soft opening promotional prices)


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Wild Horse Freedom Federation issues THE TRUTH to share Freedom of Information Act (FOIA) documents and information with the public. Be sure to subscribe HERE to Wild Horse Freedom Federation, so that you can receive email alerts.
THE TRUTH #13 – FOIA documents reveal more proof of BLM's lack of oversight of record keeping for wild horse long term holding facilities.
(Note: The BLM does NOT put wild burros in long term holding facilities. Please be sure to ask the BLM why they don't put wild burros in long term holding facilities.)
In the contracts between the BLM and most wild horse long term holding facility contractors, there is language that states:
"Provide weekly monitoring of the animals to assess their health and determine death loss. Prior to submission of the monthly invoice the contractor will conduct a complete inventory of all wild horses. The results of each inventory will be included in the monthly invoice."
"Each death shall be recorded by the freezemark and/or description of the animal, date the animal was noted as dead and then submitted on each months invoice."
Debbie Coffey, V.P. of Wild Horse Freedom Federation (WHFF) has filed FOIAs for years of invoices for all long term holding facilities. WHFF (in their White Paper issued July, 2017 found HERE) detailed that many long term holding facility invoices did not include the required freezemark number or description of dead wild horses.
FOIA documents recently obtained prove that Lili Thomas, who was the Contracting Officer's Representative (COR) and overseeing the long term holding facilities, was missing many invoices and death records in her files, and had to ask the contractors to supply them to comply with one of our FOIA requests.
Read the rest of this article and see FOIA documents HERE.
Be sure to subscribe HERE to Wild Horse Freedom Federation, so that you can receive email alerts.
Read all of THE TRUTH and see other FOIA documentation HERE.
Donate Here: http://wildhorsefreedomfederation.org/donate/
Categories: Horse News


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Cohoes- Ronald A. "Otter" Zakrzewski, 77, of Van Schaick Ave. died on Wednesday, September 7, 2016 surrounded by his family at his residence after a long illness. Born in and a lifelong resident of Troy, until moving to Cohoes in 2010, Ron was the son of the late Jacob Zakrzewski and Blanche Testa O'Neill. Ron served in the New York National Guard 1954- 1957 and the enlisted in the Army from 1957- 1960. Ron was a 25-year employee of Garden Way Mfg. in Troy where he was a machine shop supervisor and also worked in maintenance until 1987. Ron also worked for Central Market, now Price Chopper in No. Troy where he was a produce manager. Ron's working career continued at the Hoosic Valley School and he retired in 1997 from the Albany Academy where he worked in the Maintenance Dept. Ron enjoyed volunteering his cooking skills to the Salvation Army and for his church, the United Church of Cohoes. He enjoyed fishing, was a movie buff, sang in the church choir and cherished the time spent with his family and his canine companions Peanut and Noop.
Ron was the husband of the late Bonnie Lee Cushine Zakrzewski and the brother of the late Thomas and Joseph Zakrewski.
Survivors include his wife Joyce Knauer Zakrzewski, his children Ronald A. (Elizabeth) Zakrzewski of Huntington, LI., Deborah (Joe) Battaglia of Halfmoon, Susan (John) Napples of Halfmoon, Mark Zakrzewski of Cohoes and Tara (Sandro) Zakrzewski Silva of Medway, MA. His brothers John "Jackie" Zakrzewski of Waterford and Richard Zakrzewski of Menands and 5 grandchildren.
Funeral Service Sunday 5 p.m. at the United Church of Cohoes 123 Mohawk St. Cohoes, NY.
Relatives and friends are invited and may also call at the CHURCH on Sunday 2-5 p.m. prior to the service.
Interment with military honors will be on Monday, at 10 a.m. at the Gerald B.H Solomon Saratoga National Cemetery.
Due to floral restrictions at the Cemetery the family suggest donations in memory of Ronald be made to the United Church of Cohoes 123 Mohawk St. Cohoes, NY 12047.
Visit perrykomdat.com for directions and private guestbook.
September 11, 2016
United Church of Cohoes
Cohoes, NY
September 11, 2016
United Church of Cohoes
Cohoes, NY


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BUSAR celebrated it's one year anniversary this month!! Looking back, I am extremely proud of the missions and training accomplished this past year. Huge thanks to Steve Kloster and Jared St. Clair for supporting the idea and our team.
- August – Smokies Litter Team day
- September – Georgia Orienteering race
- October – Ekaneetlee ManVenture
- November – Rob Spieden Tracking class
- December – Porter's Creek, Lester Prong, "real" Bunion & Survival 101
- January – Survival 101 & Downed plane search exercise
- February – Survival 101 & Interagency SAREX
- March – Skedco Manway carryout
- April – K9 training, BTRT-E, Virgina SAR conference, litter team day & Smokies Tech Team
- May – BLRI SAREX
- June -BUSAR tech training, Swiftwater I & Black Diamond Vertical Training
- July – Swiftwater II & Black Diamond Vertical Training
- August – Swiftwater II & Black Diamond Vertical Training
Workouts – Crushing it as the weather cools off.. A couple of us needed to knock out the pack test, so we created the "SAR-duous" duty pack test. First three miles is standard USFS test – 45# in 45 min plus and additional 2 miles, switching out to SAR packs and carrying 35# kettlebells
Rescue Swimmer 1 – Herrington, Grieco, and Jernigan started the Public Safety Rescue Swimmer course, taught by Jason Benjamin. More info here:Rescue Swimmer
Black Diamond Vertical Training weekend 4 – BUSAR was again well represented at the final Black Diamond Vertical Rescue Training of the 2016 season. Excluding our dedicated, exceptional Instructors Daniel Murray, Greg Osborne, Victoria Airey and the legendary Bob Barlow (caving, innovating and instructing since the sixties) BUSAR members comprised half of the class! King Cobra, Dusken and his Lady. Danny and I proudly showed the BUSAR colors.
After the students rigged the drops, the day was spent on rope learning new skills, practicing those previously acquired, and completing the Basic and Advanced Rope Techniques Skills check-off process: ascending, rappelling, pick-offs, ascending and descending past knots, transferring from one rope to another while climbing and descending, and
Figuring out how to climb with a Rope Walker or make a climbing system from 3 random "parts"
It was another great day on the Rock. As always, BUSAR members are welcome to attend any and all sessions. Two day training is generally held the second week-end each June, July, August and September at Backbone Rock in Shady Valley Tennessee. There is a campground at the Rock. I will be your point of contact for any questions.
– Doc
GRSM Tech Team Training – Herrington, Miller, Benjamin, and Campbell attended the Smokies Tech Team training day. Great to support and integrate with the guys we will be working with in the field.
- Cataloochee Search for family of five – Spieden, Herrington, Miller, Sledge, & Benjamin before being called off
- Dusken Sledge – prior military, squad leader, mountain warfare school grad, & hiker


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- Employer
- Specsavers
- Location
- Grimsby
- Salary
- Packages up to 75K + potential joining bonus up to 10K! (terms apply)
- Closing date
- 18 Aug 2022
View more
- Job Role
- Optometrist
- Sector
- Multiple Practice
- Contract Type
- Permanent
- Hours
- Part Time
Position: Optometrist
Location: Grimsby - Lincolnshire
Salary: Packages up to 75K + potential joining bonus up to 10K! (terms apply)
Working hours: Full Time or Part Time
Experience level: You must be a GOC registered Optometrist
Specsavers in Grimsby are looking for an experienced Optometrist to join them. The focus at this store is about pulling together and working as a team to ensure that our valued patients have an excellent experience. Become our new Optometrist at Specsavers in Grimsby a highly successful store with a great reputation for staff progression and the very highest standards of customer care.
Were fully equipped with 7 test rooms, the latest clinical technology (including OCT), and a team of 20 which includes fully trained optical assistants, so everything is in place to let you focus on what you do best.
Whats on Offer?
Bespoke packages up to 75K depending on experience
Bespoke packages for newly qualified up to 60K
Flexible weekend working
Close connection with Newmedica
Full or Part time opportunity!
A welcome bonus of up to 10,000 (depending on experience)
Generous holiday allowance
Pension contribution
Support with CET
Exceptional clinical and professional development opportunities
We are passionate about the clinical development of our team, and as our new Optometrist, we would support you with extra courses and specialisms that interest you. Whatever your ambitions, from WOPEC qualifications and independent prescribing to paediatric accreditations or enhanced optical services, well do everything we can to help you be the best clinician you can be.
Our Optometrists are an integral part of our store management team, so were keen to get you up to speed outside the test room too. With ILM courses, Pre-Reg supervision and the Specsavers Partnership scheme (Pathway) all available to explore. Along with your clinical expertise this will stand you in good stead if you choose to become a store director yourself one day.
What makes us different?
The role offers the opportunity to work with Consultant Ophthalmologists both directly and via telemedicine. Secondary care level Glaucoma and cataract patient services are seen within the practice. Furthermore, consultant led training and coaching will be available in addition to the enhanced optical services expertise from our EOS Heads.
Welcome to the seaside!
This position will take you into the town of Grimsby, known for its spectacular beaches and seafood - perfect for people looking to escape to the seaside. Not only is the landscape brimming with beautiful views and architecture, it is within an easy distance of major towns including Hull, Lincoln, and Doncaster, whilst benefitting from being a short commute from some beautiful areas including Weelsby Woods, Peoples Park and Cleethorpes Beach. Despite being remote, we still profit from having a train station a short walk from the practice, and easy bus routes to the surrounding areas.
Platinum employer
Our store is an accredited Platinum Employer this means you can expect an exceptional employee experience every single day you work here. The Platinum Employer Scheme is part of the Specsavers drive to become a famous place to work. Stores with this accreditation have been verified on five key employer standards: Recruitment, Performance Management and Reward, Talent Management, Learning and Development and Employee Engagement.
What were looking for
Alongside being a qualified and GOC registered Optometrist, the right person for this position will be confident, possess a strong worth ethic and a willingness to succeed. Youll be passionate about your job and enjoy a fast-paced environment. We are looking for an Optometrist who will go the extra mile for our customers and someone who encourages their colleagues to do the same. In summary, were looking for a high calibre resident Optometrist to join us and assist in driving this excellent practice forward.
Find out more
If you like the sound of this opportunity, get in touch, wed love to tell you more about it. Contact Katie Cunningham on 01566 771892 or email@example.com.
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By Kelsi Matylewicz/ Benco Dental Social Media Intern
Angie Stone, Owner & Founder of HyLife LLC in Edgerton, WI, has combined her love for the elderly and her dental background into one profession. Her business aims to help improve the oral health of nursing home residents.
Oral care is mandatory at nursing homes, but according to a recent story in GazetteXtra, most staff members don't have much training — some only get about an hour's worth.
Stone has 30 years of experience. According to the story, Stone brushes and flosses clients' teeth, then lines their mouths with xylitol, a natural sugar substitute that makes it harder for bacteria to produce plaque. ( A typical cleaning takes about 15 minutes.)
Her inspiration to start HyLife began with two women: her mother-in-law, Gladys Stone, and her grandmother Helen Schrantz.
The former entered a nursing home with lung disease. Without a dentist or dental hygienist on staff, plaque built up in her mouth. Her lung disease continued to worsen at an alarming rate, despite the antibiotics she took, Stone said. After she passed, Stone knew the two problems were connected and she needed to do something to help.
Schrantz also entered a nursing home late into her life. In two years, she lost 60 percent of her teeth, Stone said. "I buried her with no front teeth," Stone recalled, "and as a dental hygienist, that haunts me. It should have never happened."
Stone's business, HyLife, is still in the beginning stage. The oral care component of the company began last July, and HyLife currently employees 10 caregivers in four Midwestern states and Florida.
Stone's dream is to have a team of caregivers all over the country in order to take care of this elderly population and prevent death from dirty teeth.
"In the U.S. in 2015, should people die from dirty teeth? No. I don't think so," she said. "We're doing something, and we're absolutely helping."
To read the full story: https://www.gazettextra.com/20150425/edgerton_resident_aims_to_tackle_nationwide_oral_problem


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The Pittsburgh Steelers definitely suffered a disappointing loss to the Denver Broncos on the road Sunday and now the team must quickly put that defeat behind them and start preparing for a very tough Week 13 Sunday night game at Heinz Field against the Los Angeles Chargers. The 7-3-1 Steelers opened Monday as a 3.5-point consensus favorite over the Chargers, who improved their record to 8-3 on Sunday with a 45-10 win against the Arizona Cardinals.
In the Chargers Sunday win over the Cardinals quarterback Philip Rivers was very impressive as he completed 28 of his 29 total pass attempts in the game for 259 yards with 3 touchdowns and no interceptions. Rivers also set an NFL record in that game by completing 25 consecutive pass attempts. Two of his touchdown passes went to wide receiver Mike Williams while the other one went to wide receiver Keenan Allen.
For the season, Rivers has completed 69.5% of his pass attempts for 3,119 yards with 26 touchdowns and just 6 interceptions. He's also only been sacked 19 times in total so far this season.
Allen leads the Chargers in receiving with 69 catches for 848 yards and 4 touchdowns while running back Melvin Gordon leads Los Angeles in rushing with 802 yards and 9 touchdowns on 153 total carries. Gordon, however, is expected to miss the Week 13 Sunday night game against the Steelers with an MCL injury that he suffered during the team's Sunday win over the Cardinals. That means backup running back Austin Ekeler will likely get the start against the Steelers.
Defensively for the Chargers, their top two edge-rushers, Joey Bosa and Melvin Ingram, have combined to register 7.5 sacks on the season. Bosa, however, registered his first two sacks of the season in Sunday's win over the Cardinals as the former first-round draft pick missed the team's first 9 games with a foot injury.
Chargers rookie safety Derwin James, a first-round selection this year, leads his team in total tackles entering Week 13 with 78. James also has registered two interceptions so far this season in addition to 3.5 sacks. Cornerback Desmond King currently leads the Chargers in interceptions with 3.
Including 3 postseason games, the Steelers and Chargers have played each other 32 times in total with Pittsburgh winning 23 of those contest. In the 18 games between the two teams that were played in Pittsburgh, the Steelers have won 15 of them. However, the Chargers did beat the Steelers 34-24 in the last meeting between the two teams that was played in Pittsburgh in 2012
If you would like to bet on the Week 13 Sunday night game between the Steelers and Chargers, we suggest using MyBookie.ag, a 2018 sponsor of The Terrible Podcast. If you sign up for a new account now and use the promo code TERRIBLE, they will match 50% your initial deposit. As of the time of this post MyBookie.ag has the Steelers as 3.5-point home favorites over the Chargers.


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CW Look Of The Month: 'Reign''s Queen Mary
CW stars are good looking (extremely good looking). It's not just that sexy jaw line or that "to-die-for" long wavy hair. There's more to the signature look and it's definitely worth noting.
We want to award the fashionable things that enhance our favorite CW characters including hair, makeup, style, wardrobe and jewelry. Each month we will shine light on who was the true fashionista of the CW, including both men and women.
Who did we pick for January?
Drum roll please…
Who: "Reign"'s Queen Mary, Adelaide Kane
Why: Long may this outfit Reign. We love it because it's confident and bold! Who would say no to that color?
Scene: After running away from Francis, Mary was forced to return to French court and face many decisions that she had to make. This look matched her bravery.
The Look: Queen Mary is wearing a metallic, long-sleeved, cropped top paired with a bold belt at the border of a matching metallic flared skirt. Her long wavy hair and contrasting patterns are extenuating. With this look, Queen Mary is definitely fit to rule.
Favorite Accent: THOSE long tiered earrings! These jewels are definitely her statement item. She doesn't settle for small accessories, she's Queen.
Congrats Queen Mary, the cast and crew who made this fabulous look!
Your style voice can be heard! Keep a fashion eye out during your favorite CW shows, choose your contender and send your picks our way. We will do monthly polls to see who you think should be the next CW Look of the Month.
May the fashion games begin!
for more features.


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The benefits a HVAC system can provide are numberless. They maintain the optimum indoor microclimate at optimum levels regardless of the season. Modern life would not be the same without them and just thinking about how our predecessors have survived for centuries not having such facilities sends chills down our spines. However, at some point, all of us have encountered some sort of problems with HVAC. Fortunately, there are companies providing expert services in troubleshooting and fixing problems of this type of systems. http://fandm.com.au is one on them and their services vary from plumbing to air conditioning. However, below are some problems you might encounter with your HVAC system.
Problems with dirty air filters
If you noticed that the airflow from your system has reduced considerably lately, you should consider changing the air filters. Overworking your system is counterproductive, because it has the potential to freeze and break down at some point. Other unpleasant aspect is that dirty air filters are responsible for numerous allergies and asthma. By having them regularly changed by professionals, you make sure you provide a healthy living environment for you and your family. Children are more susceptible to allergies and developing asthma therefore, you should pay great attention to this.
Your HVAC system might have electrical problems
You should first consider electrical problems if your system is not working without any apparent reason. Most of the times, if the wiring is poorly made, with time the contactors wear out and electricity cannot reach your system anymore. Have some specialists to look at them and they can certainly fix it without any hassle. In order to prevent system failures due to poor electrical work, you should have your system checked periodically.
Your thermostat stopped working
If you notice that the airflow does not correspond to your set temperature, you might encounter a thermostat failure. These devices are quite sensitive and break down easily. In addition, you might have set it unknowingly at the wrong temperature and it might appear like a failure to you. Have some specialists over to properly troubleshoot and fix or replace it for you.
The system's drain lines have clogged
The main cause for this type of problem is organic residues. They are prone to develop in humid environments and this is exactly what the drain lines are. As a result to clogged drain lines, the water can overflow and potentially damage you system's components.
Do not attempt to fix HVAC problems by yourself because of the humid environment combined with electric wiring. Professionals can solve your problems fast and without any hassle. They are working clean and can spot a problem only by looking at your system. There is no point in hiring amateurs when the fees companies like that charge are modicum. Remember that clean air filters can save you a lot of money spent on medication for allergies and asthma. Moreover, by maintaining your HVAC system properly, you make sure your family will stay at optimum temperatures regardless of the season.


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BUENOS AIRES ISSUE 100 Dec 2007
Ricardo PiÑeiro Models Buenos Aires models, actors, casting
The agency represents many top models, including Priscila Prette, Lara Bernasconi, Andrea Bolatti, Maria Cecilia Bonelli, Jimena Buttigliengo, Soledad Fandiño, Paula Peralta, Emilia Iannetta, Stephanie Demmer, Loli Lopez, Ines Pujol, and Magli Montoro, as well as many other important names in the industry.
The company aims to consolidate a growing international reputation for the quality of its fashion and advertising models by supporting talent for the film industry, TV such as FTV Sexies, fashion shows, beauty and modelling contests.
Tag your comment using @productionparadise to share with us!


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Credit score restore corporations, or "fixers", will assist you do away with destructive objects in your credit report. With mortgage amounts from $35,000 to $200,000, terms from 10 to 30 years, and no money required at closing, a home equity loan from Uncover is a straightforward option to consolidate debt, make dwelling improvements, cover school costs, and pay for other major bills. Use our home fairness mortgage calculator to estimate your monthly cost. Sainsbury's Bank Nectar Credit score Cards can be found to new Sainsbury's Financial institution Credit score Card clients solely. We treat all our clients and their applications for a Sainsbury's Bank Nectar Credit Card on a person foundation. The interest rate, promotional period and credit score restrict we provide are determined by the details you provide, together with an independent verification of credit and repayment history.
Of course, utilizing a cosigner to supply further assurance that month-to-month repayments will likely be made is arguably the very best move to make. With the mortgage practically guaranteed, getting a $25,000 unsecured loan for very bad credit administration becomes one thing of a formality. Receive as much as $300 in assertion credits every year of Card Membership for eligible purchases at taking part Marriott Bonvoy® resorts. Shopping Credit score Cards are typically affordable with a starting annual payment of Rs.500. The benefits supplied on the cards together with the welcome presents, reward points, offers and reductions, and many others., revolve round the shopping category.
Thankfully, if you are responsible with your spotty credit credit card and make your monthly payments on time, over time you may improve your credit score rating and finally get a lower interest rate. Make it possible for the bad credit report bank card you are making use of for often experiences to the most important credit score bureaus. This can insure that your credit rating will improve as rapidly as potential by having your optimistic cost activity reported. No annual price when applied by way of BankBazaar, if not Rs.1,500.
If you have already got a credit history, you can check your eligibility, select a card that suits your way of life needs and apply for it on Bankbazaar. If you do not need a credit score history, you can opt for a safe bank card often offered towards fixed deposits. Conventional lenders, like mainstream banks, are not often the most effective mortgage provider to go to. However when searching for a $50,000 unsecured private loan with adverse credit, they should be avoided as a lot as possible. Why is this? Well, all of it comes down to their phrases, and the way costly a mortgage take care of them can show to be.
Citi Cashback Credit score Card – Get money again on all of your bill spends. Do what you've at all times done but do it for much less with this Cash Back Credit Card. Plus, enjoy savings and evergreen cash again advantages all year lengthy. Seeking unsecured loans with a bad credit score is fine but there may be higher choices elsewhere. So, never bounce to the first mortgage provided; all the time take time to consider the main points and whether or not the mortgage is as good because it appears. The very best offers, after all, can be found on the Web, with on-line lenders typically charging lower interest rates.
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There are exponential perks to social media, but rarely do people consider how social media benefits SEO (search engine optimization). Of course at MySMN, we are quite the fans of everything social media, so we are going to share how social media benefits SEO.
According to Forbes, "Social SEO (a relatively new concept) encompasses the idea that social media links and interaction play a huge part in a website's search rankings. Search engines consistently give more rankings weight to SEO-type activities that are harder to create." For example, creating and distributing an original piece of content such as an infographic that ends up being shared 40,000 times is great. Whereas spending 40 seconds on a social bookmark is not so great. Because legitimate interaction between a customer and a business is extremely hard to fake, businesses that are more involved with social media have an increasing amount of relevance for search engines.
So what does this mean for your business and how can you get in on the social media SEO action? Forbes listed 10 1/2 ways social media benefits SEO and how businesses can leverage the power of this combination; here are our favorites:
- Use brand name in posts. This doesn't mean that every post should have your company name, but using the company once in a while will help Google associate your brand with your keyword posts.
- Link your social media accounts from your homepage.
- Be selective. If your company doesn't fit into the culture of a certain social networking site then don't join it.
- Get involved with Google+.
- Publish blog posts immediately on Twitter—they will be indexed faster.
- More followers= more audience= better SEO
- Be consistent. The more often your post to social media platforms, the more Google will recognize you as an expert in your field which will lead to better SEO.
This is just the nutshell version of how social media benefits SEO, but hopefully you gained a better understanding of their relationship. If you would like more information about SEO or how social media can propel your business, don't hesitate to get in touch with us!


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How to register your child
Step 1:
In order to properly care for your child, we need to know certain information about them from you. Furthermore, we also need your consent on a few items in order to proceed. If your child is participating in our youth group, this is the first step to getting them properly enrolled. Please fill out the following form:
ACP Online Youth Registration Form 2017-2018
Step 2:
In order to get the most up to date information about youth group outings and Sunday meetings, please sign up for our email group. These emails come directly from our Youth Pastor on a weekly or as-needed basis (e.g. for cancellations or changes in previously scheduled events.)
ACP Youth Parental Consent Form 2016-2017.pdf
ACP ACP Youth Safety and Injury Procedure.pdf


text: Experience Design Five design trends for 2017 Will Burroughs Experience Design 07 Oct 20166 min read Share It's that time of year again when we start to reflect on what has been and what will be in 2017. As a designer at Ridgeway, an important aspect of my role is to keep an eye on current trends to ensure the websites we design for our clients meet and exceed their expectations, whilst remaining relevant and maximising the site's lifecycle. So, read on to see some of the trends we think will continue into 2017. Broken grid layouts Broken grids have been everywhere in 2016 and we think this will continue well into 2017. The broken grid, if used in the right situation, can create visually engaging layouts which add to the storytelling of your products or services by utilising space and appearing to ignore the traditional rigid column structure of old. The broken grid approach allows elements to be highlighted and woven together, creating an ebb and flow as you scroll down the page. An example can be seen below from 100%, where they mix up structured and broken grid layouts together in a way that never feels over the top. Duotones and gradients Styles constantly fall in and out of fashion, usually reappearing when someone is able to put a fresh twist on it. This is definitely the case with duotones and gradients, which came back into vogue when Spotify unveiled its new identity, utilising striking duotone imagery. Since then, duotones and gradients have been making a strong comeback and can be utilised in a myriad of different ways from backgrounds to image overlays, textures to borders, to typography. This approach works great for hero images where it adds visual interest without overpowering the message and avoiding legibility issues. Less is still definitely more In 2016, minimal design has been more popular than ever since it works beautifully for responsive design where you not only want consistency across all devices but also fast mobile load times. Minimal design is a universal design practice, whether we are talking in the context of digital or print. Minimal design is all about the less is more approach, removing the superfluous and instead utilising white space, balance, and symmetry to craft clean, sharp, and timeless designs. This approach works especially well if your site is photographically focused, with fashion being a good example of where HD images are required to showcase products. In 2016, minimal design has been more popular than ever since it works beautifully for responsive design where you not only want consistency across all devices but also fast mobile load times. This has been enabled in part due to the advancements in technologies such as 4G, fibre, and platforms such as Kentico that perform automatic image optimisation, allowing HD images to be supported and downloaded. And with mobile usage now surpassing desktop, 2017 could be the most minimalist year yet. Typography speaks louder than images It was not so long ago that the web was limited to only a handful of system fonts. Thankfully in 2016, the web is our oyster and designers are able to push the potential of what typography can add to messaging further than ever before. Expect to see the continuation of expressive typography grow in 2017 with type taking centre stage in all its forms, becoming imagery in its own right. Custom icons and illustrations The right icon or illustration can speak a thousand words. Well, maybe not, but having custom icons or illustrations ensures you avoid the perils of the homogeneous web. Choosing to create custom icons or illustrations which explicitly convey your messaging, as opposed to a stock library approach, will not only aid your users' understanding but will also add value to your online language, giving your site greater distinction. We have seen more and more clients in 2016 understanding the value in this, and Ridgeway was recently commissioned to produce a suite of icons for one of our clients and we expect much more of this in 2017. As with all trends, some come and go and some are game changers. When it comes to your website at Ridgeway, we always treat the sensitivity of translating your brand into the digital environment as the priority. Whilst trends have a bearing on how we approach this, they have to add real value to your story and not be just another flash in the pan.


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Layoffs, furloughs coming to KCK School District due to budget cuts
Superintendent says district looking to cut $6.2M
Layoffs and furloughs have been announced as the Kansas City, Kansas, School District looks to slash its budget by $6.2 million.
Superintendent Cynthia Lane said the cutbacks include some staff layoffs, but teachers will not be affected.
The positions for the chief of human resources and assessment manager will be eliminated.
"Additional cuts will include four furlough days for all year-round employees, along with a reduction in the number of contract days for certain staff, including teacher leaders. Non-personnel related cuts include a reduction of $900,000 in funding for alternative services, a 10 percent cut to all school and department budgets, a reduction of $350,000 in textbook purchases, and reduced spending on technology, transportation, professional development, supplies and summer school, among other things," the district said in a news release.
Lane said the district reached "a tipping point" after a series of state budget cuts in recent years.
Lane added that those who supported block-grant funding, including Gov. Sam Brownback and many legislative leaders, are responsible for the significant budget cuts.
She said the new funding plan for the next two years represents a cut because of increasing costs and growing enrollment.
Lane and the school district are plaintiffs in a lawsuit challenging the block-grant plan. A Shawnee County judge has the case now.
Meanwhile, there were signs in Topeka of progress in the deadlocked state Legislature.
There were fears that if the lawmakers did not reach a new budget deal by July 1, the schools might face more funding cuts.


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LANSING, Mich. — Educational leaders from school districts covering Monroe and Lenawee counties, Jackson College, Monroe Community College, Michigan State University, and the University of Texas joined Sen. Dale Zorn for a math summit on Oct. 26 to bridge the gap between high school and college-level curriculums and end the need for remedial courses.
"Our goal is to improve partnerships and better align the curriculum at our K-12 schools with the math expectations at our community colleges, so when students graduate, they can jump right in to earning a certificate or degree and not have to take remedial classes," said Zorn, R-Ida. "We all know that education is not a one-size-fits-all endeavor, but we must find a solution that works for everyone.
"Remedial courses cost students more money and more time. Most importantly, they result in many remedial students becoming frustrated and dropping out."
When entering college, students usually take a math placement exam. Students whose scores do not meet minimum requirements must take remedial classes to get caught up. Tuition is charged for these remedial college classes, and students usually do not receive credit for them toward graduation.
In Michigan, over 27 percent of students entering college the year after graduating from high school needed to take remedial classes in the 2015-16 academic year. In math, it was 21.3 percent.
The summit was spearheaded by Zorn and held at the Monroe County Community College (MCCC) La-Z-Boy Center. Educators from the Addison, Adrian, Airport, Bedford, Blissfield, Britton Deerfield, Clinton, Dundee, Hudson, Ida, Jefferson, Madison, Monroe, Onsted, Sand Creek, Summerfield, Tecumseh and Whiteford schools were among those at the summit. Officials from the Lenawee and Monroe County intermediate school districts, Jackson College and MCCC also participated.
"We discussed a wide variety of innovative and different pathways for better preparing our students," Zorn said. "The possible solutions included incorporating more career-based mathematics in the curriculum and developing a high school transition course for students who are not ready for college math — ensuring students meet college benchmarks and ending the need for remedial courses."


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Customer Creations
We love seeing what our customers make! Nicole and Jenny from Stash and Burn came in to do a little show and tell, Nicole is wearing a garter hat in Silk Garden and Jenny is sporting a Malabrigo Chunky scarf.
Jeremy wearing a stunning vest, knit by Bob. Those wonderful, long color changes, it must be Noro. And slipped stitches create the almost houndstooth-like pattern. So dapper!
Malene models a sleek Cropped Cardigan from Blue Sky Alpaca, knit by Celia using Blue Sky Alpaca Sport. Love the shawl pin closure!
And finally, here is Jack sporting a crocheted devil hat, complete with tail!


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