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(see, you do!)
The brain. It seems to be everywhere. People do stuff because their brains told them so and some designs and even this blogpost will rewire your brain. While psychology carries the stigma of the ingraspability of our thoughts and the transience of our actions, the brain is something to hold on to: It is a physical thing and there is awesome science connected to it, sometimes producing nice images with LSD-like coloring.
This is awesome for everyone who deals with people and needs to make up for the chaotic reality. By evoking the brain we can give our ideas a foundation in science. Thus we design for left-brain and right-brain people, (ab-)use the fact that their brain makes them buy stuff they don't need and ideally target their pleasure centers.
Sounds very scientific. But do these explanations help to predict outcomes and allows to criticize and to improve theories? They rarely live up to these expectations.
Replace with new question, answer none.
Often the sciency vocabulary replaces one question (»Why does the person do«) with another question »Why does the brain do…«. And though sometimes we get some more explanation (»Neurotransmitters do…«, »Center for… lights up«) these hardly give (the layperson) the insight to use the novel knowledge to predict behaviour any better than without the sciency terminology.
Generalize to the max
Many claims are based on misunderstandings or absurd generalizations. For example, yes, there is a lot of research about brain asymmetry, and yes, there are differences between the both sides of the brain. But the idea of one half of the brain being »creative« and the other being »analytic« is hardly based in research, not to mention the idea that such differences would turn you in a person binary defined by one of these.
Complications, Correlations and open questions
Research in Neuroscience is highly complicated and prone to many hard-to-control influences. Often, cited results have not been replicated (yet) and thus hardly provide a solid foundation. And despite of all the efforts and progress which was made despite the difficulties of research, there is still much to be explored. If you look in a textbook like »Principles of Neural Science« you will come across many open questions even in seemingly basic areas.
Rebranded psychology
And a lot of what is talked about »Neuro« or »Brain« is actually psychological research which (as a rule of thumb) measures response times and chosen answers or the like (instead of going to the physical level of the brain). In addition, the theories of cognitive psychology are often easier to understand and utilize. For example, cognitive load theory can help practitioners when creating teaching materials and provides an explanation why recognition is superior to recall; Prospect Theory helps to predict and understand decisions. While still being complex, they can be probably easier understood than much of neurological research and can be utilized in practice.
What do do?
I absolutely would love if we as designers could exchange more with (Neuro) Scientists and get insights into the inner workings of the brain. However, just using terms and theories from neuroscience without having the knowledge (or interest) in using it in the frame of a criticizable theory that can help us (as individuals) to predict and evaluate does not help us much and obscures the open questions with a veil of scientific terminology. Using corroborated and graspable theories from cognitive psychology probably enables you to understand and evaluate research itself and their predictions better and will often be far easier to transfer in your domain.
- The Guardian's take on Neuromarketing
- Who is interested in neuroscience may enjoy the »Principles of Neural Science« by Kandel et.al, a textbook classic on Neuroscience. If it hardly helps with designing or business. It helps a lot with learning about a very exciting field.
- And on the left-brain/right-brain topic: Interview with a brain asymmetry researcher.


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On an uncharacteristically cool but bright and sunny late August day, yesterday Washington, D.C.-based lawyers in the Privacy and Information Management (PIM) practice traveled west one hour from DC to the Marriott Ranch in Hume, Virginia to take stock of current trends in privacy law and to discuss ways in which the practice can better serve its clients in the dynamic times ahead. After a short trail ride on horseback, the group got down to business and spent the afternoon sitting on the porch of the Marshall Manor House built in 1814 by James Marshall (the brother of then-Supreme Court Justice John Marshall).
In full-group and break-out interactive sessions, the PIM lawyers talked out how we can prepare clients for anticipated developments in privacy and information security law, including:
- Increased Congressional focus, through proposed legislation and hearings, on online tracking, data security breaches, children's privacy, and consumer control over the collection and use of personal data.
- More enforcement actions from the FTC, HHS, in the states and through attempted class actions.
- The broadening applicability of HIPAA to entities previously not covered and the applicability of "general" privacy rules to health-related entities
- Greater challenges for companies operating internationally given the proposed changes in the EU framework and increased regulatory enforcement abroad
- The further deployment of cloud computing and social media by businesses.
- The demand, created in part by greater media attention, for heightened privacy and data security protections for consumer and employee data, and the threats to reputation and brand from inadequate attention.
The group came up with a framework for ways to better inform our clients of new developments, to share our learning and to collaborate with in-house privacy professionals and to continue to distinguish our privacy practice as one known for being able to handle the entire range of privacy and data security matters, including especially those involving cutting-edge and novel issues, and one that can provide global coverage on privacy matters by involving our colleagues across the firm's 40 offices in 27 countries.
The late-Summer gathering "out West" energized the PIM group lawyers for a busy Fall ahead.

subset: commoncrawl


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Principal Residence Exemption
(Formerly Homestead Exemption)
All residents are reminded to review their tax statements annually as to the Principal Residence Exemption percentage they are receiving. The percentage you have declared as Principal Residence should read 100% and is located at the top center section of your Tax Statement. If your statement does not reflect this please contact the Assessing Department immediately at (734) 354-3267.


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Idle Time Books is, for those who haven't read this Washington Post article yet on e-sales tax (an article that somehow manages to avoid noting that existing e-sales taxes have not increased revenue) (both links via Ben Domenech at Ricochet), being presented as the Plucky Little Company That Will Serve As a Club With Which To Morally Beat The Big, Bad Amazon:
Still, local retailers hope the sales tax measures will give them a chance to compete.
"I've got to file a form every month, and I'm only one tiny business," said Val Morgan, owner of Idle Time Books, a 30-year old bookstore in Adams Morgan. "If I can do it, surely Amazon can."
Well, here's my prediction: if Congress passes some version of the Marketplace Fairness Act, then if Idle Time Books is selling merchandise online a year afterwards it'll be exclusively via Amazon.com. Because – Ben was kind enough to link to this, too – the MFA will pretty much end up being free money for Amazon.com.
I'm not sure if anybody's told Val Morgan that yet, or not.
Moe Lane
Full disclosure: I am a Maryland affiliate for Amazon.com.


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- This event has passed.
Spooktacular 2018 in Caste Village
October 20, 2018 @ 12:00 pm - 2:00 pm
Spooktacular in Caste Village is a family fun day where Caste Village merchants and community celebrate Halloween together.
There will be 4 judged categories for costume contests: Homemade/Original, Family, Cutest and Scariest. Sunshine Acres Carriage will provide free horse and carriage wagon rides. There will also be music by DJ Steve Maffie Jr. Participating merchants of Caste Village will have treats and tricks waiting at most storefronts. Caste Village is a wonderful place for family and friends. In years past Caste Village Spooktaculars have always been spectacular. Come out and enjoy a wonderful community time with the merchants of Caste Village from 12:00 pm – 2:00 pm Oct. 20th 2018.


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As soon as EliteXC: Primetime ended, the conspiracy theories started flying around the world of MMA. Many felt that the stoppage was premature and some felt that Kimbo Slice could have been stopped in the 2ndRound when James Thompson had Slice against the cage while raining down punches and elbows. When asked by Steve Cofield if Thompson's busted cauliflower ear was the reason behind the stoppage, referee Dan Miragliotta responded by saying, "no, that had nothing to do with it. Don't get me wrong that was one of the most disgusting things I've seen in a fighter ever."
"Why I stopped the fight was because of the uppercut-cross-hook-uppercut combination that knocked him on his ass," Miragliotta explained.
We here at 5thRound.com felt that Thompson was taking more punishment in the 2ndRound than he did in the 3rdRound was eventually stopped.
"I looked into his eyes, I saw the blank stare, you knew he was out of it. I stopped the fight and when I grabbed him to tell him the fight was over, he still thought he was fighting Kimbo," Miragliotta continued.
Then there was the whole controversy that Brett Rogers started about Slice tapping out when Thompson was pounding him with elbows. Miragliotta was adamant that he didn't miss it and Thompson had agreed.
"I didn't miss anything, watch the tape and then also go to the video interview with Kimbo and with James Thompson. Thompson even says in his own interview that Kimbo never tapped."
Miragliotta also dispelled all rumors regarding the fight being fixed as he clarified who referees actually work for, "we don't work for the promoters. We worked for the New Jersey State Athletic control board there."


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Contact PK or Scott for details! You will have the ride of a lifetime. We are working on an AirBnB for out of town guests. AJ of AJ's crew for a cure is pictured below ...
Great ride with friends from Seattle
We kicked off the new year with a great ride with some JDRF friends we met on the Loop who are visiting from Seattle.
Ride with JDRF in 2019
El Tour de Tucson 2018
We had a blast at El Tour with visitors from as far away as New Jersey. Come join us this year for the ride of a lifetime! As always, no experience necessary, you don't even need a bike!
Rider Profiles
No experience necessary, you don't even need a bike! We are riders of all abilities coming together to raise money for a cure and have fun! Each Friday, we will profile one of our riders on Facebook and upload them to our "Meet the Riders" page here.
Ride with us in 2017!
2016 El Tour de Tucson is in the books
If you live within two hours of El Tour de Tucson, you can sign up for the day rider program. It means you only have to pay the $100 registration fee which goes to JDRF and then you raise an additional $650. You get to take advantage of almost all the perks of riding with one of the coolest teams ever including pre and post ride dinner celebrations, getting a ride for you and your bike to the start and back from the finish line. All of our riders exceeded their goal last year and most raised more than double. We have lots of great ideas to share about how to put the fun back in fundraising!
2016 Phoenix Tour de Cure was a blast!
We kicked off the 2016 season at Bicycle Ranch Scottsdale and then Four Peaks brewery on March the 18th. Our new coaches Scott and Rick are ready to ride with Phoenix riders. Be sure to like our Facebook page to learn about upcoming events:
Riders of EVERY Ability,
riding to Cure Type 1 Diabetes


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Jayne Hitchcock panicked when the postman delivered a padded envelope with a mismatched postmark and return address. This was it, she thought; her cyberstalker had found her. She called the police and sat outside with her cordless phone until they came. It was a false alarm; the package contained a late Christmas present. "It turned out to be incense," she says. "It was so embarrassing."
Hitchcock, an author, has lived in fear since 1996 when a dispute with a New York literary agency turned into a case of online terrorism against her. As a result of her saga, she joined Working to Halt Online Abuse, or WHOA, found at www.haltabuse.org, a group established in 1997 to give cyberstalking victims the tools to fight back.
In January, WHOA released a survey containing what may be the only statistics about cyberstalking. Each week, the group reports, it receives about 100 requests for help; the majority of victims are between the ages of 18 and 25. Some 95 percent of the requests turn out to be legitimate, WHOA reveals. Of those cases, contacting the offender's Internet service provider stopped the harassment quickly 81.5 percent of the time.
If that doesn't work, Hitchcock recommends trying the police, FBI, or state attorney—or, as in her case, getting a private attorney should law enforcement offer no relief.
After Hitchcock complained about the literary agency to her misc.writing newsgroup, her name, address, and phone number started appearing on dozens of forged UseNet postings saying she was available for sex 24 hours a day. Her enemies bombed her Internet account with e-mail. The local police department gave her no help. "They didn't even know what a newsgroup is," Hitchcock says. "They weren't online. They didn't have e-mail." She did get help from her "Internet posse," 10 tech-savvy misc.writing posters who figured out the origin of the messages and helped delete them, then contacted the senders' ISPs. Law enforcement could do the same thing—if they would learn to use the tools. "Even today it's amazing how many police departments aren't as wired as they should be," Hitchcock says.
David Goldman, the founder of HateWatch.org, agrees. Goldman, who recently shut down HateWatch to launch a more personal crusade against cyberstalking (www.paragraph175.org), says hate groups draw too much attention, actual cyber-terrorism too little. "People are being harassed, stalked, and terrorized and not afforded protection by law enforcement," he says.
Young women are likely being targeted, Hitchcock says, because they often talk back to harassers in chat rooms, e-mail, and UseNet postings. "That's what harassers want," she says. "If you ignore it, most of the time it'll stop." Not always: Online wolves often trail anyone who disagrees with them. "I had no idea what was going to happen next. I was checking under my car before I got in," Hitchcock says. She even got a concealed-weapon permit in two states and joined the National Rifle Association.
Thankfully, gun-toting isn't the only defense. Internet users need to apply offline caution to the Internet, Hitchcock says. Don't go into private chat rooms with strangers; block all incoming instant messages from strangers; avoid gender-specific screen names like "Miss Kitty." Women often will enter private details like marital status, place of employment, hometown, and even measurements into public-user profiles. "Would you say that stuff to somebody standing next to you in an elevator?" she warns. "If not, don't say it online."
Hitchcock has also been pushing for a federal law against cyberstalking. A bill defeated last term did not specifically mention stalking by electronic communications. "I know prosecutors and police. If you don't have (the specific words) in there, it won't work," she says. Faced with techno-libertarian resistance to federal intervention, the die-hard techie counters that the Internet can remain free even if it's regulated to protect safety: "Hey, I'm a writer. This is not about freedom of speech. This is harassment, period. If it's illegal offline, it should be illegal online," she says.


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Cloud computing, SaaS change business as usual for broadcasters, Martinolich says
Every so often, an idea comes along that promises to change business as usual and take the broadcast industry in a whole new direction.
According to Chyron VP Jim Martinolich, cloud computing and software as a service (SaaS) may be just such disruptive technologies. Martinolich, an IBC2009 panelist during the "Cloud Production and Delivery" session, Friday, Sept. 11, says there are several good reasons SaaS is becoming accepted in the broadcast industry.
SaaS offers broadcasters lower costs, faster return on investment and the ability to pay only for what's needed. Martinolich says those types of benefits are encouraging broadcasters such as Gannett Broadcasting to transform how they create news graphics from relying on "big iron" to employing SaaS.
I spoke with Martinolich about SaaS, broadcast applications for cloud computing and what he hopes those attending his IBC2009 session will learn.
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As a reminder, the new medical center is being opened in two stages. The first stage is the opening of the medical-office building and outpatient center in July 2011.
- Emergency Room
- Imaging Department
- Outpatient Surgery
- Cardiac Diagnostic Center and Cath Lab (opening after July)
- Endoscopy Center
- Comprehensive Spine Center
- Swedish Cancer Center
- Physical Therapy
- Primary Care
- Specialty Care Clinics
- General Surgery
- Colorectal Surgery
- Orthopedic Surgery
- Hand Surgery
- Urology
- Neurosurgery
- Neurology
- Podiatry
- Gastroenterology
- Obstetrics and Gynecology
- ENT/Otolayngology
- Plastics
- Physiatry/Rehab
- Pediatric Specialty
Also opening is the caf�, retail stores and the education/conference center.
In November 2011, stage two will open — which is the hospital inpatient units, such as labor & delivery, inpatient surgery and the intensive care unit.


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Monday, March 15, 2010
Design Wall Monday #11
All of these fabrics came from my stash, which is so exciting for me... I really am making some headway in using up what I have accumulated over the years! When I first started quilting I bought a lot of darker colours like this, but now I tend to buy brighter colours, so I am happy to clear these out.
Now I just need a border or two to make it a bit bigger...with the 24 blocks it measures 48" x 72".
What's on your design wall today?
Check out what other quilters are working on at Judy's blog list - click here.
10 comments:
- Judy D in WA said...
I love this! This is one of my favorites to clear out the strip bin. Can't wait to see what you do for borders.
- Monday, March 15, 2010
- Cathy said...
Lovely, warm colours. I feel warm and fuzzy just looking at the picture
- Monday, March 15, 2010
- Quilt Rat said...
this is looking fabulous..........my gosh you are just so prolific!
Add to that the fact that each and every one is terrific, how do you do it?
- Monday, March 15, 2010
- Diane said...
Love it! reminds me of a quilt called 'scrapalicious' I made a few years ago...going to have to dig that out and take a photo.
- Monday, March 15, 2010
- julieQ said...
Oh, I love this. The depth kind of draws you in...wonderful.
- Monday, March 15, 2010
Kathy ... I love it! ... I've started cutting scraps for the scrappy bargello ... jr from Guelph
- Monday, March 15, 2010
- Greenmare said...
oooo I'm liking this!
- Monday, March 15, 2010
- Quilts And Pieces said...
I"ve made that pattern before and love it! Yours is so rich looking! It is wonderful.
- Tuesday, March 16, 2010
- Candace said...
Love it, so quilty looking in an old fashioned good way. Makes me want to make one, too.
- Tuesday, March 16, 2010
- Red Geranium Cottage said...
- Sunday, March 28, 2010


text: I have been treated over a number of years by Dr. Awad as well as at a previous location. I've had acupuncture for several different problems, ranging from various types of pain to nausea, with amazingly successful results. I have complete confidence in her knowledge and skill in these acupuncture treatments, and appreciate that Dr. Awad is a Medical Family Practitioner, as well as providing Medical Acupuncture. It is important to me to achieve relief of pain and other symptoms without relying on pain relievers and medications whenever possible.


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Now you may be thinking I'm a little nuts for being excited that my website crashed, but I'm just thrilled! The site crashed due to too much traffic and when you consider I built this website as a way to be of service, help and connect with people…I'm singing The Hallelujah Song!
This website, filled with The Secrets I Share With My Friends is dedicated to helping people get over themselves, connect with themselves, love themselves and live the greatest expression of themselves. What could be better than more traffic than what the site can handle! So excited! 🎉🎊🎉🎊
You too can choose to feel excited about the things you typically find challenging with a simple shift in your thinking. It works like this…I can choose to feel stressed and upset over the people who got an error message when they tried to visit the site this weekend and weren't able to or I can choose to celebrate those that were able to visit the site this weekend. It is 100% my choice just like its 100% your choice to be happy, mad or sad about the situations you find yourself in.
Let me give you another example of my failed attempt at a dinner party this weekend. I had a small dinner party this weekend that only one person showed up for. 😢 I was expecting another couple and had spent the entire day preparing for my guests. I busted my "arse" shopping and working around the house getting things ready for the party, all day. It was my first one since moving in to my new house as well as since my husband and I separated. I was really excited to be having company. We waited dinner for the couple who "no showed" for an hour and finally decided that they must not be coming. I never heard from them. Now, I could have sulked and felt upset, but that's not how I role. Why would I do that to myself? Why would you do that to yourself, if that's your typical reaction?
I saw it like this. I have no idea what's going on in the lives of others and what may have come up or not come up. It really doesn't matter honestly, it's not my business. Don't get me wrong about being disappointed, I was. But, the guest that was here deserved my same happy spirit no matter who else was or wasn't here. Being happy about the person who did show is what felt right and we had a great time. We wouldn't have had as nice of a time if I was consumed by who didn't show vs. who did. Easy paradigm shift that made for a totally different evening than it could have been.
I also chose to look at it like this. I got an opportunity to get my house all pretty for company and the house looks great! It feels so good for me to have my home looking "dinner-party" ready. I'm the one living here and I deserve a pretty home to enjoy, company or no company. I got some shopping done I hadn't gotten to AND we had lots of leftovers so I won't have to do a lot of cooking this week. There are so many benefits that it's easy to make difficult for myself to feel anything but gratitude.
The same gratitude I have for my website crashing. Thanks for being a part of what crashed my site!!! I have sincere gratitude for you and hope this site serves you in any way that it can.
Change your thinking…change your own life experience.
Let me know if there's something that will make the site even more valuable for you and what I can do to inspire you to live your best life.
Much love and many blessings.


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By Ted Sherman and Kelly Heyboer/The Star-Ledger
NEW BRUNSWICK — The basketball scandal at Rutgers University has not only given the school a black eye, it may also affect the state university's credit rating.
Moody's Investors Service said today the bad news coming out of Rutgers is not good for the financial health of the school, which is preparing to refinance $263 million in university bonds and take on another $484 million in debt from the University of Medicine and Dentistry of New Jersey.
In the last two weeks, Rutgers has fired head basketball coach Mike Rice, forced the resignation of athletic director Tim Pernetti and pushed out its general counsel in the wake of an investigation of Rice's abusive behavior toward his players.
"These events are credit negative for Rutgers because they draw criticism from national media and public officials, raise questions about governance and management practices at the university, and strengthen the possibility of government investigations and possible legal actions," Moody's said.
Rutgers' current Moody's credit rating is Aa2. If Wall Street rating agencies downgrade the state university's ratings, it will make it more expensive for the 58,000-student school to borrow money.
Moody's was already reviewing Rutgers' finances because of the university's impending takeover of UMDNJ on July 1. The combination of the two universities and their multi-billion budgets is one of the most complex mergers in higher education history and significantly increases Rutgers' debt.
The basketball scandal began unfolding last week when video footage of Rice shoving players and using homophobic slurs was leaked to ESPN and broadcast nationally. Rutgers officials came under sharp criticism for initially choosing to suspend and fine Rice rather than fire him.
"Like other universities that have chosen not to take quick and decisive action when confronted with inappropriate behavior by university employees, Rutgers' initial response highlights inward-looking governance and management practices that are prevalent among U.S. universities," Moody's analysis said. "Questionable disclosure practices about many aspects of U.S. university operations, including scandals stemming from athletics, invites increased criticism and government regulation of universities."
Moody's said the timing of the fallout over the Rice firing is especially awkward for Rutgers as it seeks to achieve a higher profile in two major areas— research and athletics.
By merging with UMDNJ, Rutgers is taking over two medical schools and several other health science schools. Moody's noted Rutgers currently has approximately $1.2 billion of debt and may borrow more for research facilities in coming years.
Rutgers is also preparing to join the Big Ten athletic conference, which Moody's said will bring not only a major increase in athletic revenues and national exposure, but also provide the university with an opportunity to cooperate on joint research projects with other schools in the conference.
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• Follow @starledger on Twitter
And check out our redesigned mobile site by visiting NJ.com from any mobile browser.
The Moody's report concluded the increased visibility of a successful athletics programs "can buoy student demand and donor support through the increased exposure and name recognition." But, it noted, donor support for Rutgers is likely to wane as a result of the Rice scandal.
Rutgers officials responded to the Moody's report today by saying the university is making changes as a result of the basketball scandal. The school's governing board will soon commission an independent review to investigate the circumstances surrounding the Rice case.
"The university takes seriously the behavior that came to light in the men's basketball program, and is continuing to take steps to address concerns raised by the episode," campus officials said in a statement. "The university administration is now seeking new leadership of the athletic department and the basketball program and is committed to maintaining the highest standards for governance and management across the university."
• Rutgers faces possible credit downgrade as it merges with UMDNJ
• Moody's may drop Penn State's credit rating in wake of scandal


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SENER receives 'The European' award for best infrastructure and transport company04/09/2017 (International)
SENER has won the prestigious 'The European' award for best infrastructure and transport company, as part of the British publication's annual awards programme for innovation and excellence in organisations.
This year, 'The European' has chosen to acknowledge the work of SENER in the area of infrastructure and transport with this award, which, in the 2017 edition, rewards the company's work carried out in the MENA region (Middle East and North Africa). Every year, 'The European' gives recognition to organisations and individuals that stand out from the rest for initiatives related to good governance, innovation and know-how, as well as for the quality of their products and services.
At present, SENER is carrying out infrastructure, transportation, energy and construction projects in the MENA region, in countries such as Qatar, United Arab Emirates, Algeria and Morocco.
SENER projects in MENA
Over the last 15 years, SENER has implemented projects in the north of Africa, in particular Algeria, where it has participated in works such as the extension of the Algiers metro system, and the tram and metro system of Oran. Likewise, in June 2015, the company began an ambitious project in Egypt to design two road tunnels under the Suez Canal.
SENER has carried out projects in the Middle East since 2010, when it was awarded a contract for the preliminary design of the light metro and tram system of Abu Dhabi (United Arab Emirates). Currently, it is working on the design and supervision of the electromechanical installations for the extension of the Red Line of the Dubai metro system. In addition to this experience, SENER has projects in countries such as Qatar, Kuwait, Oman and Saudi Arabia, where it provides ICE services (Independent Checking Engineer) of lines 4, 5 and 6 of the Riyadh metro system.
SENER was also responsible for designing the elevated portion of the Red South line of the Doha metro system, and is currently designing the architectural finishes and landscaping of the elevated stations of the Red South, Red North and Green lines, as well as the workshops and depots. Furthermore, the company is involved in the new port project in Doha, where it acts as an Independent Engineering Consultant of the design of the port systems.
SENER has offices in 20 countries and has worked on over 12,000 km of projects and studies, making it a leading international company in the sector. It also has a solid international reputation as a designer and provider of intelligent transport systems that incorporate high-tech solutions.


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Enjoy surfing in the unique natural environemet of San Vicente de la Barquera (Cantabria).
Surf House Sanvi is located on top of a hill overlooking fabulous San Vicente de la Barquera bay.
The Surf house is set on the first floor of a typical house surrounded by the green cantabric hills, offering unique views of the ocean, San Vicente's lagoon, the Oyambre natural park and Picos de Europa mountains. It is situated in a wonderful surf location, with many surf spots close by, suitable for all levels of surfing.
The Surf House offers 3 shared rooms with ocean or lagoon views, 2 comfortable bathrooms with bathtub, a kitchen, a terrace and a chill-out area where you can relax after a hard surf session. You can meet new friends, watch surf videos or use the free WiFi. The Surf House also features a large garden where you are welcome to keep your surf board, wash and drain you wetsuit and enjoy a delicious barbecue with friends and other guest of the House.
All guests are welcome to use the kitchen freely at any time of day or night. In addition to this the accommodation offers the opportunity to be involved in other activities such as: bicycle and kayak tours in San Vicente de la Barquera lagoon, free climbing, rafting descents through Cantabria and Asturia rivers and many more options.
Bed & Breakfast and freeshuttle surf spot/surf school+ free surfing sessions
May, June and September from 25€/Night
July and August from 28€/Night
7 nights packages
All packages include 7 nights accommodation in a shared room and breakfast at the Surf House Sanvi, freeshuttle surf spot/surf school and free surfing sessions. The atmosphere is cozy and the staff will make you feel at home.
May, June and September from 170/week
July and August from 190€/week
For more information and reservation please send an email to firstname.lastname@example.com or click on the following link
Accommodation type: Bed & Breakfast, Surf House
Price: Book Now From 23 €
Number of Rooms: 4
Nearest Surf Spot: Playa de Merón, Playa de Oyambre MORE INFO
Internet: WiFi is available in all areas and is FREE of charge
Room Type: shared dormitory room with ocean or lagoon views
Food & Beverage: breakfast is included and available from 8am till 12pm. You are free to use of the communal kitchen at any time of day or night.
Parking: free public parking is possible at a location nearby
Services/Activities: surf classes, SUP, equipment rental. The Surf House organize other activities such as: bicycle and kayak tours, free climbing, rafting and many more
Remarks: the nearest Airport is located in Santander, 60km away.
Other accommodation in the area
Hotel Josein is located right on Comillas Beach, just in front of the surf spot and has direct access from the hotel to the...
Hospedaje Granada
Best rated
Hospedaje Granada is located just outside San Vicente de la Barquera, in the countryside. It is just 600 meters...
Surfing San Vicente
Apartamentos Surfing San Vicente is located close to San Vicente de la Barquera city centre and just 100 metres from the...
Find the best accommodation and surf camps for your next surf trip
In Travelnsurf.com you will find the best surfing destinations for this summer!
¿Que tabla de surf me recomiendas para empezar?
En esta entrada intentaremos aclarar algunas dudas sobre que tabla escoger para aprender a surfear.


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Christian parents are finally offered a true Potter alternative...
All the adventure of Harry Potter...
None of the sorcery!
This week the Christian Fiction Blog Alliance is doing a blog tour for Landon Snow and The Island of Arcanum by R.K.Mortenson, published by Barbour Publishing (October 2006).
About the AUTHOR:
R.K.Mortenson is an ordained minister with the Church of the Lutheran Brethren. He has been writing devotional and inspirational articles since 1995. He currently serves as a navy chaplain in Florida and lives with his wife, daughter and son in Jacksonville.
This page at Barbour's site provides a few good links, two as recent as last week: http://www.barbourbooks.com/author/detail/r-k-mortenson/. The top link there goes to a story about Randy's adoption experiences, the second link goes to the Landon Snow short at Clubhouse magazine.
Randy got the idea for this series one late night, when flute music woke him from a sound sleep. As he stood at his window, trying to locate the source of the sound, he spied a library across the lawn. Suddenly, he envisioned an eleven-year-old sneaking out of his bed and stealing to the library in the dead of night...And thus Landon Snow was born.
The BOOK:
In the latest adventure of Landon Snow And the Island of Arcanum, Landon, once again visits his grandparents in Button Up, Minnesota. If your familiar with the first two books, Landon Snow and the Auctor's Riddle, and Landon Snow and The Shadows of Malus Quidam, you'll know that Landon's adventures always start at the Library in Button Up.
This time, Landon's most dangerous journey yet, begins in a rowboat-shaped tombstone that floats. And it's lucky for him that it floats because a few drips from the library ceiling turns into a powerful waterfall.
The stone turns into wood, the stone book propped up in the prow of the boat turns to paper. The left page says "ANCHOR". The right page says "AWEIGH".
"Anchor aweigh?" said Landon.
Holly whispered, "Did you hear that?"
No one has time to respond, however. The next instant saw the water before them dropping away as the water behind them grew into a giant swell, pitching them headlong into the abyss.
Landon will have to protect his two younger sisters, Holly and Bridget, who wind up in the boat with him headed towards The Island of Arcanum. On the Island, the animals of Wonderwood are imprisoned and the evil shadows of Landon's nemesis, Malus Quidam lurk!
With the help of some old friends, a horse named Melech, an odd fellow named Hardy, a girl named Ditty, and the poet/prophet Vates--Landon seeks to unlock the island's dark secrets and escape with the animals intact.
But first, he must navigate his way through unchartered waters and battle the villainous Archans...Can Landon and his friends rescue the animals from deep within the island's stronghold?
R.K.Mortenson's website: http://www.landonsnow.com/
Book link: http://www.amazon.com/exec/obidos/ASIN/1597893587
Wednesday, 29 November 2006
CFBA Blog Tour of Landon Snow and The Island of Arcanum
Christian parents are finally offered a true Potter alternative...
Interview with Charles Martin
On 13th October, 2006, my book club interviewed Charles Martin, author of The Dead Don't Dance , Wrapped in Rain , When Crickets Cry , Maggie and Chasing Fireflies (releasing in 2007).
We reviewed When Crickets Cry and then spoke to him via conference call. Below is the transcript of that interview which was fun and informative. Please forgive my typing errors!
Thanks again Charles for the gracious way you answered our many questions!
CM: Hello, this is Charles
NJM: Hi Charles, Narelle from Australia here. How are you doing?
CM: I'm good, how are you?
NJM: We're well, thanks. Had a good chat about your book.
CM: Oh, yeah?
NJM: Yeah. They've all made heaps of noise, couldn't stop talking and now they've gone all quiet on me!
CM: Well, don't do that!
NJM: No! We really appreciate your time so thanks for giving it to us.
CM: We're going to have to get over the language barrier!
NJM: Ok, you can't understand me?
CM: I can understand you a little bit, but it's more like after you say it. It takes about 30seconds for it to kinda swirl around in my head and then it's okay so that is what she said!
NJM: I'll speak a bit slower...
CM: Oh, that's much better!
NJM: We have a South African girl here so that will be even better!
CM: Oh goodness! How many of you are there?
CM: Ok. It sounds like you have a good phone or something because I can hear all of you. A lot of times when I do this whoever is calling me I can't really hear but you all sound really, I can hear you really well.
NJM: That's good, you just can't understand us!
CM: I have no idea what you are saying!
NJM: Well, this a new experience for us too, this conference call so we will just see how it all pans out.
CM: It's not necessarily new for me but its something that I am still a little , like, I mean its sort of a strange thing, I mean don't you all have something better to do than sit around and talk to some guy in Florida and Georgia at this time of night on Friday the 13th or something?
NJM: We're all, you know, enjoying a night together!
CM: There's the truth of it. I'm curious, since your there in Australia, here right now it is the morning of the 13th. What is it where you are?
NJM: It's 9.15 on the night of the 13th.
CM: Ok. So you're almost 15 hours ahead.
NJM: Something like that – we like being ahead of the pack! How about we get into it?
CM: Ok
NJM: One of the favourite questions, no doubt you have heard it before and will probably have your answer all ready, what inspired you to wrote When Crickets Cry?
CM: A couple of things. If you read any of my other stories, especially The Dead Don't Dance, you will see in the acknowledgements, that, um, I am 36 now, when I was 27 Christy and I were out then at Virgina Beach. It's on the east coast of the United States and it's about due east of our capital. Anyway, we were out there at Graduate School and I was travelling to work one morning for UPS. Do you have UPS there? Postal service?
NJM: Something like that.
CM: Anyway, I was going to work for this big shipping company and I had to be at work about 3am so its about 230am and I am driving to work and I had this flash or this, I don't know, this picture that I kinda saw that was pretty detailed for me and I guess I had seen them most of my life but never really paid attention to them and I mean its just a daydream that I see in sort of technicolour. And I made some notes, I always carry a little notebook with me, and I made some pretty detailed notes and as the months went by it sort of became more solidified and that's when I sort of strapped a novel around it and that became The Dead Don't Dance. That has occurred to me with most, all of my stories now and I finished, I guess I've written five novels now.
With When Crickets Cry the first thing I saw was a little girl in a yellow dress standing on a street corner in Clayton, Georgia, selling lemonade and the thing that struck me was a scar on her chest, it was just a little scar and a little pill container. Somewhere along that time, this kind of all happened around the same time, I began thinking about the heart and just, I don't know, just sort of this miraculous thing I hadn't thought of, here's this little organ that sits in the middle of our chest and it really ticks non stop until thay day you die, it never takes a break, it never takes a vacation. Something about that amazed me.
And then the first part of this equation was, Christy and I have three boys and the boys and I were reading somewhere in Proverbs and we ended up in the fourth chapter and the Psalmist was trying to give his admonition to his son and it starts in the second chapter and goes all the way through the third and it ends in the fourth and for some reason we got to the middle of that fourth chapter where he says "above all else guard your heart" and it just struck me, I don't know why, but it just struck me that here is the wisest man on the planet, saying "above all else".
Those three things occurred within about a week of eachother – the picture I saw in my head, my thinking on the heart, then Charlie and that got me going towards the book that you all read.
To read the full interview, click here!
Read my review of The Dead Don't Dance
Read my review of the sequel Maggie
Tuesday, 28 November 2006
Freefall by Kristin Heitzmann
5 stars
With December just around the corner, I imagined I had read all of the best books of 2006. By the end of the first chapter of Freefall I knew I was mistaken!
Set on the Hawaiian island of Kauai, Freefall commences with a woman tumbling down a waterfall and the testing of Monica Pierce's fragile emotions. Monica's instinctive compassion welcomes the beautiful but injured stranger into her home, her memory lost due to the traumatic fall. Monica names her Jade. As a result of a tragic childhood, Monica has always relied heavily on her protective older brother, Cameron, an insurance fraud investigator living on the mainland. Monica calls him to utilise his investigative skills to determine Jade's identity. Upon his arrival, Jade's reluctance to contact the police places Cameron's suspicions into overdrive and another man's life in the balance.
When Jade's identity is confirmed as the latest Hollywood "it" actress, Gentry Fox, the ugly side of such fame threatens to overwhelm her as she struggles to remember her past. Cameron's immediate derision of her occupation and the lifestyle he imagines Gentry has sought, is tempered as Gentry's strength of character emerges as they search for answers to the tragedy that befell her. In turn, Gentry glimpses Cameron's cynical and hardened exterior for what it is, a damaged heart and soul, following the early loss of his parents and his wife's more recent betrayal. Cameron resists his attraction to Gentry as danger continues to haunt her. The suspense ramps up and the relationships of all characters are tested as unscrupulous people seek to destroy Gentry's image and possibly, her life.
Kristin Heitzmann has written a powerful novel of suspense alongside a beautiful character study of the fragile yet indestructible nature of human emotions. Her characters have depth and authenticity, from Gentry and Cameron through to blind Okelani, Monica and police officer, TJ Kanakanui. The book delves into issues of integrity, the allure of wealth, the burden of guilt and the miraculous and forgiving nature of God. Secrets and Unforgotten are must read books but Kristin Heitzmann has trumped even those with Freefall.
Thursday, 23 November 2006
Remember Nick?
Susan May Warren, one of my favourite authors, is launching her Noble Legacy series with a Meet Nick site and giveaway!
Reclaiming Nick releases in January, 2007 and here's a sneak peek..............
Nick Noble hadn't planned on being the prodigal son. But when his father dies and leaves half of Silver Buckle—the Noble family ranch—to Nick's former best friend, he must return home to face those he left behind. And to make sure that the Silver Buckle stays in the Noble family.
Award-winning journalist Piper Sullivan believes Nick framed her brother for murder, and she's determined to find justice. But following Nick to the Silver Buckle and posing as a ranch cook proves more challenging than she first anticipated. So does resisting his charming smile.
As Nick seeks to overturn his father's will—and Piper digs for answers—family secrets surface that send Nick's life into a tailspin. But there's someone who wants to see the Silver Buckle leave Noble hands, and he's willing to do whatever it takes to make that happen, even if it means taking a life.
Click here to register for a chance to win a bundle of Susan's books!
Monday, 20 November 2006
CFBA Blog Tour of Cool, Calm & Adjusted by Kristin Billerbeck
Kristin Billerbeck was born in Redwood City, California. She went to San Jose State University and majored in Advertising, then worked at the Fairmont Hotel in PR, a small ad agency as an account exec, and then,she was thrust into the exciting world of shopping mall marketing. She got married, had four kids, and started writing romance novels until she found her passion: Chick Lit.
Calm, Cool, and Adjusted is the third book in the Spa Girls Novels.
Billerbeck did a great job with the characterization of Poppy, a quirky Christian chiropractor who is a health nut. I'm talking real NUT. She is so obsessed with health that she forgets about living. When she finally realizes that she is over the edge obsessed, she doesn't know how to stop herself.
Best friends since Johnny Depp wore scissors for hands, "The Spa Girls" live very separate lives, but stay in touch with routine visits to California's Spa Del Mar.
The third novel in the Spa Girls Series focuses on Silicon Valley chiropractor Poppy Clayton, who is as calm, cool and adjusted as they come. Or is she? Known for her bad fashion sense, a love for all things natural and the inability to get a second date, Poppy is beginning to wonder if she might be misaligned herself. Her route to self discovery will be an unnatural one - a plastic surgeon, a dilapidated house in Santa Cruz, a flirtatious client, and a blind date from the dark side.
It's all enough to send a girl - and her gal pals - running for the comfort zone of their spa
Thursday, 16 November 2006
Interview with Amy Wallace
Welcome to Amy Wallace, author of Ransomed Dreams and fellow CFBA blogger to Relz Reviewz.............
Rel: Thanks Amy for joining me! Please share some of your writing/publishing journey with us
Amy: I began my writing journey oddly enough. In searching for good stories to share with my girls one Christmas, I came across some grown-up novels. Devouring my first taste of fiction since my college years, I'd then hand the books to my husband and tell him how I'd change them. After about seven, my husband handed a book back and said to write my own. I shook my head. But then a dream about FBI agents and a mom in trouble wouldn't be dismissed. So I wrote the story and got involved in an awesome writer's group called the American Christian Fiction Writers. I spent a little over three years learning the heart and craft of writing, all the time working on a number of novels, short stories, and proposals. Then I received a recommendation for an agent who loved my first book and we signed a contract. Eighteen months later the publishing house I dreamed of working with offered me a three-book contract.
Boy, does all that sound nice and easy. Actually this journey has been anything but. It's more closely resembled a difficult pregnancy than a walk in the park. But God returns me to a few basic things: He called me. He promised to equip me. And I rise and fall to Him alone. The other big thing God reminds me of often is that writing is an act of worship. True worship is costly, so says 2 Samuel 24:24. It's my constant prayer that with every step of this writing journey I'll offer up to God a pleasing sacrifice, an offering that has indeed cost me something.
Who encouraged you or what made you decide to write a novel and seek its publication?
I think it was my intent from typing the first word that I'd seek publication because I wanted someone to hear the story I had to tell. It never occurred to me not to try. God was gracious to put some amazing writers in my path who read my pitiful fledgling attempts and took me under their wings, showing me kindly how to improve . They also encouraged me to keep at it. So I did. I love that many novelists say the key to good writing is putting your backside in the chair and doing the work. I'd add praying all the way is the best way to retain your sanity.
Why Christian fiction?
Christian fiction is simply a natural fit for who I am and how I view life. My husband and I share a life's passion to know God and show others how He heals hearts and how we can glorify God by enjoying Him forever. We tend to focus on the Body of Christ to live out that heart desire, but are open and willing to go where He sends us and share with anyone He puts in our path.
I note you homeschool your children. What does a typical writing day (or night!) look like?
A typical writing day looks like a Saturday. :-) That's the day I work from 9am to after midnight and get the majority of my writing done. I attend to edits and business things during the week while my children have afternoon quite times and then I also work after bedtime.
As a confessed chocoholic, what do you recommend to get you through those difficult writing days?
Godiva is my chocolate of choice! But any chocolate will do on those tough days. On really difficult days, I pair my favorite dessert with a white chocolate mocha from Starbucks and lots of prayer. Together those help me salvage and learn from even the worst of writing times.
What are you working on now?
Ransomed Dreams will release in April, 2007 and now
Why FBI Agents and children?
I wanted to be an FBI profiler after I graduated college. But that's not the path God intended for me. Instead I get to interview, read about, and then write about people I admire~ without having to do all the pushups. LOL Why children? I adore my children and am passionate about them being a gift to treasure and helping tired moms (what mom isn't tired?) remember that.
When writing these books, did the plotline or characters come first?
That's a tough call. I'd have to say I knew the characters first, but the basic plot came hand in hand with Gracie and Steven. It was in telling their story that I got to know them, which made the rewriting of the entire book go well and end up being a story I'm excited about sharing.
Do we "see" some of you in your characters?
Totally. But it's not the obvious character choices. In truth, there are bits and pieces of who I am in every character.
Many authors say they "hear" their characters talking to them. How does it work for you?
I don't really hear my characters; I see them. It's like having a movie reel playing all the time in my head. Often that's incredibly distracting. But the cool thing about the way I'm wired is I see these stories and characters as ways the Holy Spirit speaks to me. Many times God touches on areas where I'm weakest or leads me to explore my greatest fears. In telling the best and most intense story I can, I walk it through with my characters and I'm changed. I love that part of being a writer. Especially when I don't have to get shot at to learn!
If you were casting actors for a movie of Ransomed Dreams, who would you choose?
That's tough because even though I "see" my characters, I see more of their inner life than physical descriptions. Besides, I'm woefully inept in keeping up with Hollywood names and faces.
The Defenders of Hope website has a page with resources for protecting children. This is obviously something very close to your heart. Can you explain your passion and what you hope to achieve?
My best friend says that when we're at a mall she's looking for great shoes while I'm monitoring the exits. I totally resemble that statement. Growing up military behind the Iron Curtain, I used my imagination early to dodge "spies" and concoct stories of what would happen if. Now as a mom and a suspense writer who does tons of research, my imagination takes me places I hope to never go in real life. I'm painfully aware that we don't live in a safe world. So I want to share all I've learned with other moms as well as to encourage parents to not walk by fear, but be armed with knowledge tempered with faith in an all-powerful God.
Do you read Christian fiction yourself? If so, some favourite authors or books both Christian and/or secular?
I LOVE Christian fiction! My all-time favorite author is Dee Henderson. Mark Mynheir, a cop writer, is at the top of my list too. I also really enjoy Robin Jones Gunn and Kristen Billerbeck. Three new entries to my favorites list are authors Karen Ball, Rene Gutteridge, and Trish Perry. I love to read everything these authors write and I wait a tad impatiently for their next release.
Where is your favourite place to read a book?
Anywhere with chocolate. :-) I especially love reading outside or reading side-by-side with my hubby curled up on the couch.
Who inspires you?
My children. They love life and they love God unapologetically. They work hard, play hard, and get back up when they mess up. They also forgive easily and love deeply. I want to grow up to be more like them.
Please share some of your faith journey
I was an alcoholic at age 13 and a total type A personality on a crash course toward destruction. When my military family moved back home to Louisville, KY I made a friend in my sophomore German class who invited me to church. I ran for cover. What little I knew of God conjured pictures of thunderbolts and scowls. But try as I might to avoid church, I eventually slipped through the doors of a Baptist church and heard for the first time that God wanted a relationship with me and that the cross was proof positive He was serious about sin as well as able to cleanse and heal me and make me a beloved part of His family. I think I wore out the entire church staff and youth group with my endless questions. I didn't receive many answers that satisfied, but when I realized the depth of my sinful aching heart and that God still asked me to come, I stepped into the most amazing love affair ever. I was 15 then, and while there have been plenty of times I've said "this is NOT what I signed up for" I've come to see there is no better place to be than in the arms of my Savior experiencing the love of my heavenly Daddy.
Any last words.................................
My prayer for my readers is that they will come face to face with the God who smiles at them and longs to draw them closer and closer to Himself. I also pray they'll know deeply His never-ending love and heart healing so that they'll find their passion and live fully the story God has placed them in.
Thanks Amy for sharing so honestly - you have been a delight to interview :) I can't wait to read Ransomed Dreams. Look for my review in early 2007!
Amy is a fellow CBFAer so check out Amy's Blog for more of her thoughts.
Wednesday, 15 November 2006
Blog Tour of Scoop by Rene Gutteridge and Interview
This week, the Christian Fiction Blog Alliance is posting about Scoop by Rene Gutteridge
Rene Gutteridge is the author of several novels, including Ghost Writer (Bethany House Publishers), Troubled Waters (Bethany House), The Boo Series (WaterBrook Press) and the Storm Series, (Tyndale House Publishers. She has released three novels in 2006: Storm Surge (Tyndale) My Life as a Doormat (WestBow Press, Women of Faith)Occupational Hazards Book #1: Scoop (WaterBrook Press).
She has also been published over thirty times as a playwright, best known for her Christian comedy sketches. She studied screenwriting under a Mass Communications degree, graduating Magna Cum Laude from Oklahoma City University, and earned the "Excellence in Mass Communication" award. She served as the full-time Director of Drama for First United Methodist Church for five years before leaving to stay home and write. She enjoys instructing at writer's conferences and in college classrooms. She lives with her husband, Sean, a musician, and their children in Oklahoma City.
The Occupational Hazards Books are a series of books about seven homeschooled siblings whose last name is Hazard. The parents died in a freak accident leaving the kids ages 16-26 with a lucrative clown business but the kids realize that God has other plans which doesn't include being a family of clowns for the rest of their lives.Scoop, is the first of the series and centers around Hayden, who was age 20 when her parents died. If you haven't yet guessed by the series title, this book is packed with many laugh out loud moments and great one liners.
Hayden is a strong Christian who, having been homeschooled, lacks some of the politically correct social norms...like not praying in front of everyone during a crisis. She finds herself in an internship at a television news station with a boss that takes stress pills, an aging news anchor that everyone wishes Botox on, a weatherman who wants to predict love for himself and Hayden, and a reporter struggling with his own politically correctness of being a good reporter and being a Christian.
Old School meets New School meets Homeschool. A smart and funny read.
Rel: Unfortunately Scoop hasn't made its way Down Under yet but having read and loved every one of Rene's previous books (both humourous and suspense), I have no doubt Scoop will be a keeper.
Here is a brief interview Rene was kind enough to give me on short notice:-
You have a young family, what does a typical writing day look like for you?
It's been easier since the kids have gotten into school. My son goes all day in 1st and my daughter half a day in Pre-K, so I write every afternoon for 2 1/2 hours, and on Tuesday and Thursday mornings as well. I'm trying my best not to work on weekends.
Characters or plot - what comes first for you?
It truly depends on the story. Sometimes the characters have come first, sometimes the plot, and sometimes the 'what if' question!
Who reads your books to check the humour really works?
Ha! That's a good question! Well, of course my editors always look at them and give me feedback, but pretty much the only person that decides if the humor really works is me. However, I have a really high standard. If I'm not laughing out loud then I know my readers won't either.
How many Occupational Hazard books can we expect?
So far three! Next up is Snitch, due out in May, and then Skid, coming in 2008.
Choose a cast for Scoop ( remember running a competition for Boo?! I won a book!)
Well, let's see, I don't really have one in mind yet. I will have to give this some thought...
Do we see glimpses of you in Scoop?
Oh sure. I'm in nearly every character, except maybe Hayden. I would like more of Hayden in me.
Your favourite fiction reads?
Right now I'm taking a little break from fiction, catching up on some non-fiction I've been wanting to read. Jesus by Leith Anderson is phenomenal. Life changing! I am loving it. Also highly recommend Lessons from the Carpenter by H. Michael Brewer. Okay, you asked for fiction! I have a lot of favorites, too many to list here.
Share some of your faith journey
Lately I've been learning about a heart of gratitude. It's really a life changing lesson, and one that I'm only getting small glimpses of right now. But I know if I can grab a hold of this, it's really going to make my life amazing.
Thanks Rene - a pleasure as always :)
Monday, 13 November 2006
Maggie by Charles Martin
www.charlesmartinbooks.com Read my review of The Dead Don't Dance
4 1/2 stars
Maggie continues the poignant journey of Dylan and Maggie Styles introduced in Charles Martin's excellent debut novel The Dead Don't Dance . Martin did not intend to write a sequel when he completed The Dead Don't Dance but his readers will be grateful he changed his mind!
Maggie has awoken from the coma into which she fell after the traumatic labour that ended in the stillbirth of her firstborn son. Dylan, forever grateful for her restoration believes, "All the world was right.". As with all tragedy those it strikes are permanently changed and life never returns to what it once was. Dylan and Maggie struggle to adjust to the emotional and physical fallout from their trauma and as life becomes complicated and their hopes for a family diminish rapidly they need to find a way to hope again.
Parallel to their story, Martin develops the intriguing yet damaged character of Bryce Kai McGregor, whose penchant for playing the bagpipes naked added so much humour to The Dead Don't Dance . In Maggie, his eccentricities are highlighted and explained, as Dylan discovers the horrors through which he has lived, survived but remains scarred in the deepest places of his heart.
Dylan and Bryce's friendship is one of the many treasures to be discovered in this novel. Dylan's childhood friend, Amos and his wife, Amanda Lovatt also return as part of the tapestry which connects this sequel so seamlessly to The Dead Don't Dance .
Charles Martin's characters tug at your heartstrings due to their authenticity and his ability to convey the inner workings of their hearts and minds. His secondary characters are of the same quality and substance as his main characters being one of the many factors that set Charles' writing apart. While the number of tragedies befalling the young couple and their friends escalate at an alarming rate, the story is saved by Charles' unique literary style and unequalled character development. Charles' use of symbolism throughout his novels is beautifully done and his avoidance of tying up all the loose ends neatly is a credit to him and a compliment to his readers.
Read my review of The Dead Don't Dance
The Dead Don't Dance by Charles Martin
4 1/2 stars
The Dead Don't Dance was Charles Martin's debut novel and it clearly stamped Charles as an author to watch. Charles' books have become a "must read" for this reviewer!
The Dead Don't Dance weaves the heartrending tale of Dylan and Maggie Styles, a young couple seeking to make ends meet on their South Carolina farm, while eagerly anticipating the birth of their first child. Their joy is stripped away with the stillbirth of their son, the physical and emotional trauma leaving Maggie in a coma, and Dylan distraught and self-destructive. As the doctors hold out little hope for Maggie's recovery, Dylan stumbles blindly through his grief and commences a journey which will bring him to his knees before he discovers hope in the wilderness of his despair.
Charles Martin's prose is simply a joy to read. He has an uncanny ability with the written word, conjuring pictures in his readers' minds and expressing emotions with painful clarity. Written in the first person, Dylan's tender love for Maggie is transparent and touching, his grief palpable and confronting. The minor characters are well developed, add humour, substance and believability to a novel that is not to be missed.
Read my review of the sequel Maggie by Charles Martin
Revealed by Tamera Alexander
4 stars
Revealed is the second book in Tamera Alexander's Fountain Creek Chronicles and readers will be pleased to know that Tamera has written another powerful story of two broken people seeking redemption from their past. This is the story of Annabelle Grayson and Matthew Taylor, pivotal characters in Tamera's first book, Rekindled.
After the death of her husband, Annabelle chooses to follow his dream and travel to Idaho and the land he had claimed. She wants to start afresh and locate her young friend, Sadie who has disappeared. Annabelle advertises for a trail guide to accompany her on the arduous journey and is shocked to discover that Matthew Taylor, her late husband's brother, unwittingly reponds. Matthew despises Annabelle and wants nothing more than to expose her as the conniving and immoral woman he believes she is.
Tamera's deft hand writes a tender and realistic story of two people struggling to move beyond their tainted past into a fresh and forgiven future. Annabelle and young Sadie's haunting past is sensitively portrayed as is Matthew's guilt and regreat over his broken relationship with his brother. Matthew's unforgiving prejudice towards Annabelle reveals a tendency in most of us to pass judgement on prior behaviour rather than on a person's current character and conduct. Revealed is a moving story which challenges you to consider how you view those around you in light of God's grace and forgiveness to us all.
Thursday, 9 November 2006
Coming Thursday 16th Nov......
My interview with Amy Wallace - wife, homeschooling mum, chocolate lover and author of the new Defenders of Hope series, releasing in April, 2007 with Ransomed Dreams.
Wednesday, 8 November 2006
Blog Tour of The Cubicle Next Door by Siri Mitchell
The Cubicle Next Door by Siri Mitchell
5 stars
Siri Mitchell has crafted another beautiful story, as unique as it is
thoughtprovoking , interspersed with humour, delightful characters and the anticipation and heartache that characterises an attraction between a man and a woman.
Jackie Pert Harrision, a civilian working at the US Air Force Academy, has created a life for herself which is predictable and safe, protecting her emotions from the hurt of her mother's desertion. Jackie's security is disrupted when her office is divided forcing her to share with Lt. Col. Joseph Gallagher, a new Academy lecturer. In order to vent her frustrations with this new situation Jackie begins an anonymous blog and is surprised at the interest it creates among readers. As Jackie starts to experience conflicting feelings for Joe, her blog becomes the only way she can express the joy, fear and confusion he has caused. When she discovers Joe has been reading the blog she is terrified he will discover her true identity and all she has fought to hide will be laid bare.
Siri Mitchell's characterization is superb! You will easily relate to Jackie and the supporting characters as realistic people who could live next door. Even Joe's initial "perfectness" is tempered as more of his history unfolds. Written in the first person, you will literally laugh and cry with Jackie, her heartache palpable to the point of agony at times but I guarantee it is well worth the ride. Excerpts of Jackie's blog and other bloggers' responses make a fascinating end to each chapter. As with Siri's other books, the message behind Jackie's journey of discovery will stay with you long after the last page is read.
Now you have read my review, keep going and read what Siri had to say in my interview with her.............
Siri, welcome to Relz Reviewz and thanks so much for giving us a glimpse into the life of an author.
Rel: Please share your writing journey with us.
Siri: I had been writing for 10 years, had written 4 books (the first no one will ever see; the second was Something Beyond the Sky ; the third was Christians Should Be More Parisian; the fourth was Chateau of Echoes ). I had accumulated 153 rejections from publishers and editors. And the thought of writing another book without a guaranteed sale was just too much to ask. So when publisher approached me about writing a fifth, I replied. "What an intriguing idea!", all the while thinking, 'Not on your life, buddy!" I let the idea drop for a couple months. Then God and I had a little chat. I told him concentrating on the things I didn't have (i.e. a published book) was destroying the happiness that other parts of my life offered. Although I loved writing, I'd decided that it wasn't worth the sacrifice. I was becoming bitter and cynical about everything. I told God I'd follow up all the trails I had at that point (several publishers to follow up with, etc.) and that if, at the end, there was no positive response, then I'd consider it a sign and stop writing. After that conversation, I got back in touch with an agent I'd contacted 4 years earlier. A month later (while we were visiting Canberra in fact) I got an e-mail that he wanted to represent me! And my last trail to follow was the one with the editor at Harvest House who had suggested the fifth story above. I got back in touch with him, scheduled a meeting, and wrote a few sample chapters. They liked what they read and contracted Kissing Adrien and Something Beyond the Sky. Chateau of Echoes was picked up by NavPress because a different author's book had fallen off their schedule. They needed something fast and my agent sent them my manuscript.
Rel: A number of your books are set in countries other than your homeland, America (Kissing Adrien & Chateau of Echoes are both set in France). Why have you chosen to do that?
Siri: I've always been interested in other cultures. Even when we lived in Canada, I was fascinated by the differences in the cultures of two countries that are neighbors. Whenever I live outside the U.S., I try to look for the positive aspects of the cultures I'm living in. So many of our Christian friends assumed Europe is spiritually-dead and that we'd have a terrible time when we moved to Paris. Our experience was exactly the opposite. In writing this book I tried to show those well-intentioned friends how God is everywhere. Christianity is not an indigenous religion. Not for any people of any nation. None of us own it; we can't brand it with a national patent. But we can share it with all people of all nations. Because God doesn't just speak our language, he speaks everyone's language. I also wanted to investigate the idea that our Christianity may be cultural, not biblical. That some of the things we assume are necessary to faith are actually only necessary to our culture. I found some of the American parts of my Christianity were irrelevant in France. So what did that mean? It certainly didn't mean God was irrelevant, it meant that my idea of him was. Since we're created in God's image, I think we all (even in our corrupted state), reflect pieces of him. And different cultures reflect different pieces of him. That's why I think heaven will be so revelatory: we'll all be together and we'll be able to see God in his reality, not through poorly pieced together shards of him.
Rel: Have you written your books while living in the country it is set in?
Siri: Alas, no. It would have been much easier that way! I find I'm always at least one location behind. My husband is in the military, so we move a lot. From France we moved to Colorado Springs and it was there that I wrote Chateau of Echoes. From Colorado, we moved to Tokyo where I wrote Kissing Adrien. From Tokyo, we moved to our current assignment where I wrote The Cubicle Next Door (set in Colorado) and where I am currently writing a book about Tokyo. The worst part of writing about France when I was in Tokyo is that we'd put half of our books into storage (including most of our European guidebooks, because why would we need those in the middle of Japan?!) And our large wall maps of France and Paris as well. I had to buy a few reference materials like a one-way street map of Paris. I also use the internet for research. I have a very visual memory, so that helps a lot. I also prefer writing about places I've actually lived or visited, so that adds to the authenticity I think.
Rel: Do you read a lot Christian fiction if so who are some of your favourite authors?
Siri: I read both Christian fiction and general market fiction. Susan Meissner's books are always heart-wringing. Ginger Garrett is my good friend and her books are wonderful. I love Tim Downs Bug-Man series – such a creative idea. I enjoyed Lorena McCourtney's Ivy Malone books. I read Lori Wick's 'Sophie's Heart' every year; it's like an old friend. I'm a big fan of historical mysteries. In the general market, I like Laurie R. King's Mary Russell series. I loved Ellis Peters Brother Cadfael mysteries. I guess I like history in general. I'll read in binges: medieval histories for several months; WWI for several months, etc. One of my favorite authors is Rosamunde Pilcher. Her characters feel like normal people and her plots aren't contrived. (Contrived plots or coincidences are big taboos for me – my editors will not let me write that way.)
Rel: Why do you write Christian fiction?
Siri: Mostly because I have a Christian worldview. I view the world through a Christian lens. I may experiment with a book for the general market if I can make the time, but it would still have themes that would be familiar to any Christian and it's simply because that's who I am.
Rel: Have you been published in the secular market?
Siri: No. But interestingly enough, in the U.S., Christian fiction is the fastest growing segment of the publishing industry as a whole (in both Christian and secular markets). I'm not sure if it's the same in Australia.
Rel: Please share a brief description of your journey with God.
Siri: I was raised in a Christian home by loving parents. We moved around when I was young (even spent 4 years in Canada), due to my father's job, so we attended churches from many different protestant denominations. When it was time for university, I chose to attend a secular university. I don't know whether it's the case in Australia, but in America, Christians seem to have developed a separate but parallel culture. i.e. Christian schools, Christian music, Christian books, Christian fashion, Christian gyms and health-clubs, etc. I guess I just wanted out of the Christian fish bowl. Not for any bad or rebellious reason. I joined a sorority and enjoyed it, while still holding onto my Christian beliefs. While I was there, I came into contact with people making poor choices or living non-Christian lifestyles, but I was voted into the position of sorority 'Chaplain.' Instead of reading platitudes or reciting cute little poems, I 'preached' in non-threatening ways. Mustn't have been too offensive, because I was president by my senior year. During those university years, I learned that people really watched the way I lived my life. That my actions spoke much louder than my words; that the best way to reach people was to be genuine rather than self-righteous. (And to do a lot of listening.) God taught me a lot of lessons about not judging people…which he continues still to teach me today!
Let's see…after university I worked on campus for two years, during which time I met my husband (he was getting a master's degree). We were engaged 6 months after we started dating and married one year (to the day) of our first date. My husband has taught me everything I know about having fun. He's much like Adrien (from Kissing Adrien)in that way. He's helped me understand that having fun (for fun's sake alone) can also be a virtue.
When we moved to France (4 years), God taught me all about culture and faith and that if He doesn't look like what I expected him to, that maybe the problem is with me and my assumptions and perceptions.
When we moved to Tokyo (2 years), God taught me that he is always with me, even when I can't see him. That faith still works even in cultures that are very foreign. There's only so much planning you can do ahead of time, only so much you can do to prepare. And then you just have to trust that the things you know and the things you have will be capable for the experiences that lie ahead. At some point, you have to move beyond preparation, past observation and just push out into life…however foreign to you that life might be. Maybe you sometimes feel like you're stuck in the back of beyond; that you're of no use to yourself or to anyone else. Maybe you feel like you're just killing time until your life gets back to normal. The problem is that God doesn't have enough of us to waste. No matter what you think, God has you where he's placed you for a reason. Maybe he needs to teach you something, maybe he needs you to teach someone else something. Whatever the case may be, it's best to just redefine 'normal' and get on with living life.
Rel: Borrowing one of Kevin Lucia's questions, who would you cast in the roles for "Cubicle"?
Siri: Hmm. For Jackie I'd say Selma Blair or Natalie Portman. (Actually, I would have said Winona Ryder or Ally Sheedy, but that would be showing my age, wouldn't it?)
Joe, it would have to be Ben Browder.
Adele: Gloria Stuart
Betty: Julie Christie
Grandmother: Olympia Dukakis
Thelma: Judi Dench
Oliver: David Kelly
Rel: What are the projects you are working on now?
Siri: I just finished my draft for next summer's release, Moon Over Tokyo (which you were kind enough to read for 'Australian'!). The story centers around Allie and Eric, high school classmates (and enemies) who are suddenly reunited in Tokyo nearly fifteen years after high school graduation. Moon Over Tokyo is a novel that questions stereotypes on many different levels. Filled with exotic sights and sounds, from the din of Tokyo to the temples of Nikko, the shores of Kamakura and beyond, the novel follows Allie as she re-discovers her voice, re-thinks her past, and re-shapes her future.
Rel: Siri, thanks so much for your time - it has been a pleasure "visiting" with you!
Click here to see my review of Chateau of Echoes by Siri Mitchell
Friday, 3 November 2006
And the winner is......................
Fiona :)
I have passed on your details to the publicist for Coldwater Revival so hope your copy gets to you soon!
Thursday, 2 November 2006
Defenders of Hope Series by Amy Wallace
Book description
Gracie Ann Lang is being watched by a man who will stop at nothing to hide the truth from her.
Having lost the only man she ever loved and the children who were her world, the truth is all Gracie wants—an explanation for what really happened. She longs to move forward but is bound by chains of fear. Then she meets Steven Kessler, an FBI agent assigned to uncover an international plot to kidnap the British Ambassador's daughter.
Steven awakens more than memories; he revives the possibility of a life Gracie desires. A life where healing and peace crowd out the nightmares. But his case and her past are dangerously connected. Suddenly, Gracie must decide if she's able—let alone willing—to pay the required ransom to redeem dreams and restore hope.
Ransomed Dreams is to be released by Multnomah Books in April, 2007.
Amy has recently launched her Defenders of Hope website which includes descriptions of all the books in the series, a fantastic competition and important information about protecting our children.
Amy's own website is also a great place to visit!
Coming soon.......my interview with Amy.
Wednesday, 1 November 2006
FIRST Day Blog Tour of Coldwater Revival By Nancy Jo Jenkins
It is November 1st, time for the FIRST Day Blog Tour! (Join our alliance! Click the button!) The FIRST day of every month we will feature an author and their latest book's FIRST chapter!
This blog is featuring a contest to win a
copy of Nancy's new book, Coldwater Revival. Just put in a comment and you
may be the winner!
Just three weeks before her wedding, Emma Grace Falin has returned to her hometown of Coldwater, Texas, consumed by a single, burning desire. She must confront the guilt and shame of a devastating event that has haunted her since childhood.
"...What a stunning debut novel."
--Wendy Lawton, Literary Agent, author of Impressions in Clay
"An astonishing debut! Coldwater Revival is a hauntingly beautiful story made doubly so by Nancy Jo Jenkins stunning, lyrical writing. I was mesmerized from cover to cover."
--Deborah Raney, author of A Nest of Sparrows and A Vow to Cherish
AUTHOR INTERVIEW: Meet Nancy Jo...
Q. How long did it take you to write Coldwater Revival?
A. I perceived the idea for Coldwater Revival in June, 2003, and completed the manuscript in March, 2005.
Q. Tell us about your journey from writer to published novelist.
A. During my teaching career, I dreamed of the day when I could write the stories that continually swam around in my head. I didn't know at the time that it would take me four or five years of attending workshops, conferences, retreats, lectures, and of studying tapes, books and other materials before I was ready to put my newly-acquired knowledge to use, and begin writing the stories that God had prompted me to write. In March, 2004, at the Mount Hermon Christian Writing Conference, I submitted a book proposal to Steve Laube (Literary agent), and Jeff Dunn, (Acquisitions Editor) for RiverOak. Both gentlemen asked me to send them all I had written on Coldwater Revival, which at the time was 109 pages. During the summer of 2004, both men offered me a contract. My book was published by RiverOak and released in May, 2006.
Q. The agony and healing Emma Grace went through are so real. What personal experiences did you draw from to portray Emma Grace's feelings so well?
A. There was a time in my life when I suffered with depression, though it was not due to a death in the family, as Emma Grace's was. At the time, it seemed that I was in a daily knock-down, drag-out fistfight with sadness. I was truly blessed in that I was never prescribed any kind of medication to treat my depression, which proved to be relatively short-lived. But I did receive counseling, which was just what I needed to win the battle with this debilitating condition. During that time of depression I endured many of the symptoms that Emma Grace suffered through. Excessive sleeping was about the only symptom we did not share. There were times when I couldn't swallow my food, and times when I could almost touch the face of that same blackness that almost overwhelmed Emma Grace. Her sorrow and guilt were difficult scenes for me to write, and I found myself crying each time I wrote about Emma Grace's sadness and the continual ache in her heart.
Q. Emma Grace loses all desire for life when her brother dies - not eating or talking, just living in the blissful cocoon of sleep. Do you have any advice for folks who are in that dark place right now?
A. Communication was the key that unlocked the door of depression for me. Communicate with God, even if the only words you can utter are the words, "Help me." But I also benefited greatly from talking to a certified counselor; one who was trained in helping people express their pain, their needs, their fears. I hope that anyone who feels sad and lonely for an extended length of time, will contact their pastor, or someone who can direct them to a Christian counselor.
Q. Emma Grace's grandmother lives in the city while the rest of the family lives in the country. Why do you think she didn't move out to the country with the rest of the family long ago?
A. Granny Falin immigrated from Ireland to America with her husband and son when Emma Grace's papa was just a lad. This family shared a dream about their new country. It would be a place where they could find work and prosperity, raise their family, and put down roots. Even the Great Hurricane of 1900 couldn't wash those dreams from Granny's heart. Though her only remaining child lived a hundred miles away in the rural township of Coldwater, Texas, Granny could never leave Galveston. The island and the sea that surrounded the island were her home now. It was where the ashes of her husband and three children were buried. It was the home she and her husband had dreamed of during their desperate years together in Ireland. If she left Galveston and moved to Roan's home, she would be giving up the dream she had shared with her husband.
Q. Papa and Elo have a tough time showing their emotions. Elo, especially, is so hard to read in the book. Why do you think some people hole up inside themselves rather than sharing their emotions?
A. I believe we are born with a portion of our personality already deeply embedded within us. Some people are reticent to express their feelings and emotions, while others have no problem whatsoever in expressing what they feel or think. I have known many individuals who are like Elo; people we sometimes refer to as "the strong, silent type". Papa and Elo are powerful protectors and providers who waste little time and effort on words. Both of these men feel that "actions speak louder than words". Added to that is the fact that Elo feels extreme discomfort when his mother and sisters are emotionally distraught, therefore, he maintains a rigid demeanor, in part, to provide a stable link in the chain that makes up his family - The Falins.
Q. Do you have other books coming out soon?
A. Thank you for asking about my upcoming books. I'm about to submit my proposal for a novel entitileld, "Whisper Mountain". This story takes place in the early 1900's in the Great Smoky Mountains. It is the story about lost love, and a desperate woman's journey to fill the void that deprivation and loss have left in her heart. The story has elements of mystery, intrigue, murder, and of course, romance. I'm very excited about this story. I've also begun writing a sequel to "Coldwater Revival" which will parallel both Emma Grace's life after 1933, and the adventurous trek Elo begins when he falls in love.
Coldwater Revival
Coldwater, Texas
Three weeks before I was to marry Gavin O'Donnell, I set my feet upon the beaten path leading to Two-Toe Creek. What I had to offer Gavin in marriage—my whole heart, or just a part—depended on the
decision I would make today.
As my feet tracked the dusty pathway they stirred loose soil to the air. My heart stirred as well, for the guilt I had buried in its depths smoldered as though my brother had just died, and not five years earlier. In the shadowed days following the tragedy, my disgrace had glared like a packet of shiny new buttons. I'd not thought to hide it at the time. In truth, I'd thought of little, other than how to survive. But at some point during that time of sorrowful existence, when my days and nights strung together like endless telegraph wires, I dug a trench around my heart and buried my shame.
From that day until this, I deeded myself the actor's role, closing the curtain on my stain of bitter memories, hiding my sorrow behind a veil of pretense. But that old deceiver, Time, had neither softened my guilt nor put it to rest; only allowed it ample pause to fester like deadly gangrene. Now, as the day of my wedding drew near, my heart cried out for healing. It was, you see, far wiser than my head. My heart understood its need for restoration—before I exchanged wedding vows with Gavin. For this reason, I now walked the trail to Two-Toe Creek. To revisit my failures of yesteryear and reclaim the peace that had slipped past the portals of my childhood. Perhaps then I could give Gavin the entirety of my heart.
Rel'z Review - 5 Stars
Coldwater Revival is a book replete with wonderful characters, beautiful prose and emotive scenes that take you on a journey that will leave an imprint on your heart and mind for some time to come.
A young Emma Grace Falin realises just weeks before her wedding the need to return home to Coldwater, Texas to expunge the guilt and torment she has lived with for five years following the tragic loss of her little brother, Micah. In an attempt to do this, Emma delves into her childhood memories of growing up with little material goods but surrounded by the love of her parents and siblings until tragedy shatters the family and community in which they live. Emma relives her spiral into despair, the fear of her parents that she will not recover and the journey to her Grandmother's home in Galveston, a woman also shaped by her own experience of grief.
Nancy Jo Jenkins' debut novel is captivating! I was swept away by the palpable loss sustained by Emma and the additional grief that befalls the family when Emma sinks into depression despite the love and compassion of those who grieve with her. Nancy Jo Jenkins' portrayal of the fragile Emma, the stouthearted yet broken brother Elo, compassionate parents Roan and Annaleen, and Tate, the young man refined by flames in his own life is exceptional. A story doesn't get much better than this!


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I am leading Digital HR at Capgemini Invent Switzerland. I support CHROs and their HR leadership teams in reinventing HR – from strategy development, operating models designs to IT landscape evolutions. In addition, I help HR and functional leads to plan and execute workforce transformations by applying process excellence, automation, up- and reskilling as well as market-leading talent acquisition, shoring and sourcing practices.
I combine more than 15 years of HR line and consulting experience with deep knowledge in maturing and emerging technologies. After having been with SAP and Accenture as well as supporting companies of all sizes across almost all industries in multiple European countries, I joined Capgemini in 2020. Being an "New Work" ambassador and passionate trainer, I educated more than 500 professionals in design thinking, innovation and agile ways of working.


text: Immunotherapy targeting glioblastoma initiating cells (GIC) is considered a promising strategy. The up-regulation of Rabbit Polyclonal to CDK10. the NK cell inhibitory molecules HLA-E and MHC class I was balanced by immune stimulating effects including the up-regulation of nectin-2. In 3 out of 5 GIC lines tested we found a net immune stimulating effect of IFN-β in cytotoxicity assays using NKL cells as effectors. IFN-β consequently warrants further investigation as an adjuvant for immunotherapy focusing on GIC. Intro Despite multimodal methods including surgery radio- and chemotherapy the effectiveness of glioblastoma treatment remains limited with an overall survival of about one year [1 2 New restorative options are needed to conquer this devastating disease and the use of immunotherapy is considered a promising option [3]. Possible strategies comprise immune check point inhibitors such as ipilimumab or nivolumab as well as active cellular immunotherapy or vaccination. The feasibility and security of such methods has been shown in humans however no controlled trial has shown a relevant and powerful improvement of survival of glioblastoma individuals (examined in [4-7]). Glioma cells communicate ligands for activating immune receptors like natural killer group 2 member D (NKG2D) or DNAX accessory molecule (DNAM)-1 [8-11] and should therefore be prone to acknowledgement and elimination from the immune system. The insufficient response to immunotherapies may in part be due to immune evasive mechanisms in gliomas such as the down-regulation of ligands for NKG2D by transforming growth element (TGF)-β [8 10 11 and specific miRNA types [12] or the appearance of immune system inhibitory proteins like HLA-E or-G [13-15]. New adjuvant strategies can help to overcome resistance to immune system control in glioma. Interferons (IFN) have already been explored as adjuvants for immunotherapies in cancers entities like melanoma or renal cell carcinoma in human beings [16]. The sort I IFN (IFN-α and IFN-β) and type II IFN such as for example IFN-γ will be the greatest characterized and medically most relevant IFN. Arousal with IFN network marketing leads for an up-regulation of gene appearance aswell LBH589 as antigen display in dendritic cells (DC) [17-19] and glioma cells [11 13 15 18 improving antigen-presenting capabilities. Moreover recent reviews in humans and mice describe an immune-independent direct anti-tumor activity of IFN-β [20]. Glioma cells may be sensitized towards the alkylating agent temozolomide (TMZ) [21 22 and mixed therapy of IFN-β and TMZ led to a favorable final result in sufferers with tumors with O6-methylguanine DNA methyltransferase (MGMT) promotor methylation [23]. Modulation of tumor vasculature [24] down-regulation of MGMT appearance [21 23 and induction of apoptosis by IFN-β separately of MGMT-mediated level of resistance to temozolomide [25-27] have already been discussed as systems of the anti-glioma effect. Predicated on these LBH589 multi-directional actions IFN-β warrants additional evaluation as an adjuvant for anti-glioma immunotherapies perhaps bridging innate and adaptive immune system responses [28]. An essential issue for a highly effective immunotherapy of glioma may be the description of the mark. Glioma cells with stem cell-like properties are said to be needed for tumor relapse and initiation. These glioma-initiating cells (GIC) are described by their stem cell-like properties of self-renewal multipotency and tumorigenicity in immunodeficient mice developing tumors resembling the LBH589 original individual tumors [29 30 We lately discovered the atypical individual leukocyte antigen (HLA-)-E as an immune-compromising element in GIC [13]. The connections of HLA-E using its receptor the dimer Compact disc94/NKG2A network marketing leads to inhibition from the lytic activity of LBH589 organic killer (NK) cells towards GIC. Furthermore a disintegrin and metalloproteinase (ADAM) 10 and 17 cleave the UL16 binding proteins (ULBP) 2 in the cell surface area of GIC. This hampers NK cell activity against GIC since ULBP2 is normally a ligand of NKG2D. The various other NKG2D ligands which may be portrayed on GIC are MHC course I chain-related antigen (MIC)A and -B and UL16 binding proteins (ULPB)1-6 [8 11 Furthermore nectin-2 and LBH589 poliovirus receptor (PVR) ligands of DNAM-1 are said to be essential LBH589 immune-stimulating protein present on GIC [11]. Right here we define the web aftereffect of IFN-β treatment over the innate immunogenicity of GIC. Methods and Materials 2.1 Materials and cell lines The GIC lines GS-2 GS-5 GS-7 GS-8 and GS-9 have been previously characterized for stem cell properties [31]. LNT-229 glioma were kindly provided by N..


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Leaves are falling and so are the temperatures. Perfect time to get that garage ready.
Here are 5 easy steps to a better garage.
- Sort it all. Put items in groups of "keep", "give" and "toss".
- Toss it. Trash any items that you haven't used in years and has seen better days.
- Give it away. If you're not using something that is in good condition, donate it.
- Organize and store your tools, cleaning supplies, sports equipment, etc.
- Protect the floor. Sealing and coating your garage floor will make a huge improvement
Contact us for more ways to get that perfect garage!


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Talking Guitar
Talking Guitar: Nail Care
We all care about the guitar we play, the strings, capos, pedals, microphones and amplifiers we use to get our desired guitar sound, but what about the one thing that is directly influencing the quality of the sound we are producing? For fingerstyle guitarists, caring for your nails is vital to achieving the most balanced tone possible across the strings.
In this video, Michael Watts talks through his routine for caring for his nails, the impact it has on his own tone, and what you can do today to improve yours.
We stock Wolfram nail files, which are specially designed for guitarists to maintain nail strength and promote a more balanced tone. Head on over to our Wolfram Nail File page to check out the different models available.


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My entry for Ludum Dare 37 (theme: one room).
You're an interior decorator, and your job is to give your clients nice and shiny new homes. Take note of their demands and try to give them exactly what they want.
- a whopping 8 different pieces of furniture!
- a massive two (2) unique clients!
- almost 30 furniture styles!
- arrow keys: move cursor/select item and style
- Z (circle): new item/pick up item/place item/confirm/continue
- X (cross): finish decorating/delete item/cancel
Feel free to post screenshots of any neat rooms you decorate!
Not entirely satisfied with this one, could have gone further with it but I started losing motivation toward the end. I think it's a neat concept and I have some unexplored ideas on where it could go next, but I'm doubtful I'll keep working on it post-jam.
The cart is released under CC4-BY-NC-SA, so if you want to remix it or expand upon it (like adding more furniture or clients (or just cleaning up the spaghetti code)), I encourage you to do so.
haha I love the dialogue screens with the bouncing dudes and bubbly background
Great game! Link for other LDers: http://ludumdare.com/compo/ludum-dare-37/?action=preview&uid=29223
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