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Poverty is no disgrace.
Her mouth was dry, and her hand shook as she raised it to touch the place on her neck where Vasile, Alpha of their pack, had only moments ago caressed her gently with his thumb. Something so insignificant, and yet it was the most precious touch she had ever received. He was gone now, along with his two warriors and her father. Females could attend meetings, but really there was no point. The males would be too busy trying to protect their mate if they were there, and then they would not get anything accomplished.
She had not moved from the place where he had left her. Her shoes were suddenly filled with lead too heavy to lift. Her eyes stared, not seeing anything in front of her as her mind raced, and she battled her will. She wanted to flee, to hide from the male who had affected her so. She also wanted to throw herself in his arms and make him promise never to leave her again. But instead of doing either, she just stood there frozen with indecision, doubt, and, to her surprise, curiosity. While he had been next to her, she had felt as if she could fly, but now her body felt heavy and uncoordinated.
"Alina," her mother called to her yet she still could not move. She heard her footsteps coming closer and knew that her mother would want to know what was wrong, and for once she was afraid to tell her?afraid she would insist she pack and leave with him at once and afraid she would not.
"He is the one, no?" she asked.
Somehow Alina managed to get her head to perform a wobbly nod. Her eyes finally shifted as she looked at her mother. "How could you tell?"
Georgeta's lips puckered. "Tsk, girl, I know a male on the hunt when I see one. He was staring at you as though you were the ripest fruit plucked from the harvest and dropped in his lap. I might have even seen a tad bit of salivating."
That finally made Alina move as she laughed at her mother. The thought of any male salivating over her, especially one such as Vasile, was indeed ludicrous. She was no great beauty, she knew that, and usually that did not bother her. "You must not have seen him clearly, Mother. Had you seen his expression from a more direct position, you would have seen the scowl plastered on his handsome face as he glared down at me."
"He is quite lovely, is he not?" Her mother beamed at her.
Alina crossed her arms in front of her and narrowed her eyes. "I hardly think your mate would appreciate you saying so."
"Did you notice how tall he was? And that hair was so dark and thick," her mother continued completely ignoring her. "His lips were definitely worth a second glance."
Alina stomped her foot, childish, but unavoidable. "Enough! How can you carry on so?"
"Feeling a bit possessive, dear?" Her mother's knowing eyes sparkled at her.
Alina turned and walked towards the house needing to sit down in the shade for a few minutes while she gathered her thoughts.
Her mother took the chair while she sat on the edge of her bed. She looked around their tiny home, so simple, but it met their needs. So why was she embarrassed? "He lives in a castle. His wardrobe is probably the size of our entire house. I just . . . I do not," she stumbled over her words as she ran her hands over her thighs repeatedly.
"Well," her mother breathed out. "I never thought I would see the day that a pretty face and full purse made my daughter tuck her tail and run."
Alina's eyes snapped up. She could not believe her mother had just said that to her, but even in her wounded state she knew she was right. "I do not feel like myself," she admitted. "Ever since I saw him standing there?confident, beautiful, and not appearing as if he needed anything from anyone?I have just felt inadequate. What could I possibly have to offer him?"
"Perhaps you need to get to know him before you pass judgment on either of you. I know you are sixteen in less than a month, but you are still young in many ways. Give him time to show you the man he is before you decide who he is not."
A knock at the door had both of them turning, and before Alina could see who it was, her stomach dropped in anticipation but quickly righted itself when Sisily, her best friend, walked in.
"When you did not show up I was worried about you," she said biting her lip in her usual manner when she was unsure of herself.
"I am so sorry, Sis." Alina stood quickly and went to her friend. "I did not forget; I just got held up."
"But what she really wanted was to be held down," her mother muttered as she walked past the two girls into the kitchen.
"Mother!" Alina's face flushed as she glowered at Georgeta.
Sisily was grinning from ear to ear as she looked back and forth between mother and daughter.
Georgeta shrugged. "I, unlike you, see no reason not to celebrate and enjoy the beginning of true mates joining, bringing hope to those still waiting." She looked at Sisily pointedly.
Sisily was bouncing on the balls of her feet, too focused on Alina to notice the look. "You have met your true mate? Who is he? Is he from another pack? Is he handsome? Did he…."
"Sisily, stop," Alina interrupted her exuberant friend. She glanced at her mother who now wore a smug smile. "How about we go to our usual meeting spot and talk," she suggested.
Sisily happily waved to Georgeta as she rushed after Alina. "Are you in a hurry?"
Alina slowed immediately, realizing that she was letting her emotions get the best of her and taking it out on the closest thing she had ever had to a sister.
They sat by the edge of the river, picking at the grass and tossing sticks into the water. Alina knew that Sisily would not begin speaking until she started first. She had gotten her initial shock out of the way and was now willing to be patient. She was a good listener.
"Vasile, the new Alpha is here," she finally said. Sisily nodded but did not comment. "He came by our house earlier this morning and had two warriors with him." She paused drawing in a shaky breath. "I felt him in my mind. The pull to go to him was…was…strong, as though I had not felt or drunk a drop of liquid in ages and he was the rain. I wanted to run to him, to be covered by him, and to be drenched in his scent as he washed away everything that came before him."
"Which one?" Sisily exhaled as she fanned herself.
Alina nearly laughed at the sight of her friend flustered and breathless. The smile faded as she looked away back to the slow running water. "Vasile."


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Hawaiʻi Police Department
Community Policing, Area II
Officer Bryan Ellis
Phone: 326-4646, Ext. 257
Media Release (update)
Hawaiʻi Island police are renewing their request for information about a 16-year-old Hāmākua girl who was reported missing.
Shalee Minamishin was last seen in the Hāmākua District on July 31. She is described as 5-foot-3, 100 pounds with brown eyes and long brown hair.
Police ask anyone with information on her whereabouts to call the Police Department's non-emergency line at 935-3311.
Tipsters who prefer to remain anonymous may call the islandwide Crime Stoppers number at 961-8300. All Crime Stoppers information is kept confidential.

subset: commoncrawl


text:
This is not the official web site of
Nørrebro Bryghus
Bryggeriet Cosmo A/S
Ryesgade 3
DK-2200 København
Telephone: +45 35 30 05 30
Hours: Monday-Wednesday 11:00am-midnight, Thursday-Saturday 11:00am-2:00am, Sunday 10:00am-10:00am.
[Contact] [Update]
DK-2200 København
Telephone: +45 35 30 05 30
Hours: Monday-Wednesday 11:00am-midnight, Thursday-Saturday 11:00am-2:00am, Sunday 10:00am-10:00am.
[Contact] [Update]
Visited: May 23, 2008
Opened: 2003
U.S. Importer: Shelton Brothers
Contributors: Jacob Sjúrður Hansen, Mario Kornmesser
Lots of excellent guest beers, too, and its own beers are bottled for sale all over Denmark.
Updated: January 14, 2013
- 2010-03-01: Nørrebro Bryghus Fires Anders Kissmeyer (Brookston Beer Bulletin)
Beer List
5.00% abv.
Date: May 23, 2008 (#7057)Package: draughtPlace: at the breweryScore: 17 pointsAppearance (3)
Pale golden. Thick head.Aroma (4)
Grainy malt. Huge spicy, herbal hops.Mouthfeel (8)
Light body, moderate carbonation. Hugely sweetly grainily malty. Mild noble hop flavor, low bitterness.Overall Impression (2)
Good clean beer.
3.50% abv.
Date: May 23, 2008 (#7059)Package: draughtPlace: at the breweryScore: 14½ pointsAppearance (3)
Golden amber. Nice head.Aroma (3)
Very very toasty, biscuity.Mouthfeel (7)
Medium-light body, smooth. Hugely biscuity, grainy, sweet. Low alcohol content apparently comes from underattenuation.Overall Impression (1½)
Sweet, grainy beer.
6.50% abv.
Date: May 23, 2008 (#7070)Package: bottledPlace: at the breweryScore: 16 pointsAppearance (3)
Deep golden. Thick head.Aroma (3)
Mild caramel malt.Mouthfeel (8)
Medium body, smooth. Lots of sweet caramel malt. Mild Kent Goldings hop flavor, not a lot of bitterness.Overall Impression (2)
Fruity, clean, simple beer.


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MENLO PARK (AP) — It's showtime for Facebook. Call it the second act after its rocky initial public offering two months ago. On Thursday, the company will take the spotlight once again for its first earnings report as a public company.
Facebook's fate hinges on its ability to convince businesses that the ads on its website and on its mobile application are effective. To do that, the world's largest online social network needs to keep its nearly 1 billion users logging on as often — and for as long — as possible, interacting with each other as well as with brands.
The release of its quarterly financial results will be Facebook's chance to prove to investors that it can continue growing revenue from the ads it serves on its popular social networking site.
It comes a day after Zynga Inc., which contributed to 12 percent of Facebook's revenue last year, reported disappointing earnings. Facebook's stock slid in after-market trading Wednesday, as did Zynga's.
Though there's a lot riding on Facebook's second-quarter earnings report, Wall Street analysts aren't expecting big surprises.
Why? Facebook effectively warned investors before its IPO that Wall Street's expectations were too high. In a filing issued a week before its IPO, Facebook said its mobile users are growing at a faster pace than the number of ads on its mobile platform.
As a result of that disclosure and others, many analysts reduced their estimates for Facebook's projected revenue and earnings.
On average, analysts are expecting Facebook to post earnings of 12 cents per share on revenue of $1.16 billion, according to a poll by FactSet. In all of 2011, it had net income of $1 billion and revenue of $3.71 billion, according to regulatory filings.


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July 27, 2021 — Minneapolis, MN: Tarshish Cody attorneys Benjamin Tarshish, Adam Strauss, and Kyle Kosieracki were selected to the 2021 Minnesota Super Lawyers Rising Star list. This was the fourth consecutive selection to the Super Lawyer Rising Stars list for the firm's Consumer Protection and Class Action attorney Adam Strauss. The firm's Personal Injury […]
Minnesota Business Debt Attorney
Consumers are protected by the federal Fair Debt Collection Practices Act (FDCPA) as far as third party debt collectors hired to collect debts owed to others. This law forbids third party debt collectors from harassing or embarrassing debtors. Some of these forbidden practices include calling at inconvenient hours, disclosing personal information to friends, neighbors, co-workers, or family. It is prohibited to deceive debtors by concealing collection agency identities, their purpose in calling, or other misrepresentation. Consumers should know this law does not apply to "first" parties attempting to collect their own debts, such as banks and financial institutions.
The Consumer Financial Protection Bureau enforces federal consumer protection laws. The CFPB published a bulletin entitled, "Prohibition of Unfair, Deceptive, or Abusive Acts or Practices in the Collection of Consumer Debts." This announcement gave notice that many FDCPA prohibitions will be enforced against companies who fall under the purview of the CFPB (first party debt collectors).
Call the law firm of Tarshish Cody PLC to confirm if you as a consumer have been injured and may qualify for claims against a debt collector who has contacted you. Our attorneys will schedule a free initial consultation. Call 952-295-3935.
Here is a list of prohibited acts that the Consumer Financial Protection Bureau will enforce against first party debt collections:
- Collection or assessment of a debt (and additional amounts) in connection with a debt not expressly permitted by an agreement that created the debt or permitted by law
- Failing to record payments in a timely and accurate manner, or failing to credit a consumer's account with a payment received on time, and subsequently levying late fees against the consumer
- Repossessing property without a legal authorization.
- Providing a consumer's debt information (without consumer's consent) to a consumer's employer or co-workers
- Misrepresenting the legal status, amount, or character of a consumer's debt
- Representing a debt collection attempt as from an attorney
- Representing that a debt collection message is from a government source or a source affiliated with the government
- Falsely claiming information about payment or nonpayment will be furnished to a credit reporting agency
- Falsely claiming that a consumer's debt could be waived or forgiven by agreeing to a settlement offer, if the company does not actually issue a waiver or forgiveness
- Representing that any action will be taken that is not made in good faith or without necessary authorization such as false threats to sue, to arrest, to prosecute, or to imprison for nonpayment of a debt
The declaration from the CFPB makes it clear that it will use its authority to prevent Unfair, Deceptive, or Abusive Acts or Practices (UDAAP) by applying the FDCPA laws to first party debt collectors. That means companies that originate financial products and services who collect their own debts, must implement policies and procedures to prevent and find these prohibited acts if they exist in debt collection activities.
Contact a Tarshish Cody PLC attorney to assist in determining your rights under these consumer protection laws. We welcome your call today at 952-295-3935 (or fill out the free case evaluation form below) to help you through the legal issues of your business debt case.


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YEREVAN—Armenia's National Security Service said on Monday that 47 people have been arrested in connection with the seizure of a police compound on July 17 by a group calling itself the "Daredevils of Sasoun," which surrendered Sunday saying they did not want bloodshed in the country. Meanwhile, disgruntled citizens continued their protests demanding a "legitimate government" in Armenia.
The NSS said that among the 47 were the 20 "Daredevil" members who laid down their weapons and surrendered on Sunday, ending a standoff that gave way to massive protests calling for regime change in Armenia. The NSS said that 10 members of the group had been arrested earlier.
According to the NSS, some political figures who had been rounded up last week are among the 47 being held in connection with the police compound seizure. The agency did not provide names.
After announcing their surrender, Varujan Avetisyan, a leader of the "Daredevils of Sasoun" said that they would continue their struggle for radical reforms as "political prisoners."
In announcing the group's surrender, the NSS labeled the group "terrorists," but in announcing the 47 arrests the agency did not cite the legal provisions in Armenia's criminal code that deal with "terrotism."
Armenia's Health Ministry reported that there were 17 people still hospitalized as the result of clashes between police, demonstrators and journalists on Friday, among then three police officers and two journalists, who continue to receive medical treatment at area hospitals.
© 2021 Asbarez | All Rights Reserved | Powered By MSDN Solutions Inc.


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European Project on Mendelian Forms of Parkinson's Disease (MEFOPA)
Research Areas
At a Glance
- Status: Completed Consortium
- Year Launched: 2010
- Initiating Organization: European Commission Seventh Framework Programme (FP7)
- Initiator Type: Government
- Disease focus:
Parkinson's Disease
The European Project on Mendelian Forms of Parkinson's Disease (MEFOPA) is a consortium that advances the basic and clinical research on rare Mendelian forms of Parkinson's disease (PD) by identifying and validating relevant disease-related molecular pathways, drug targets, and biomarkers for disease susceptibility and progression.
MEFOPA focuses on the molecular pathways underlying inherited forms of PD with autosomal-dominant and autosomal-recessive inheritance. By integrating cellular and animal models, with the latest analytical technologies, MEFOPA aims to provide targets for novel, disease-modifying treatment strategies. In a third subproject, a European registry and biobank for patients with rare Mendelian forms of PD will also be established. Body fluids will be collected and systematically analyzed by unbiased proteomic techniques as well as by focused analysis of candidate proteins, and ex vivo cellular models will be generated, in order to allow validation of disease-related alterations detected in the models analyzed in subprojects 1 and 2.
Through this integrated, translational approach combining basic and clinical research groups, MEFOPA aims to achieve measurable progress in defining the relevant targets and readouts for disease-modifying therapies and will set the stage for rationally designed drug trials in carefully selected groups of patients and even presymptomatic mutation carriers.
The mutations in the dominant genes are thought to cause PD by a gain-of-function mechanism. SNCA- as well as most cases of LRRK2-related PD are pathologically characterized by aggregates of a-synuclein ("Lewy-pathology"). It is therefore appropriate to assume that the pathogenic mechanisms of SNCA- and LRRK2-related PD interconnect. Research on the pathogenesis of those Mendelian forms of PD is coordinated in subproject 1.
Autosomal-recessive mutations in the genes for parkin, PINK-1, and DJ1 are believed to exert their pathogenic effect because of loss of some essential protective function. There is converging evidence suggesting that dysfunction of all recessive PD genes contribute to a state of increased cellular stress because of mitochondrial dysfunction and increased burden of radical oxygen species (ROS) and that at least two of the recessive PD genes, parkin and PINK1, operate within one single pathway. The molecular underpinnings of recessive Mendelian forms of PD will therefore also be investigated together, in subproject 2.
The findings in the basic science work packages of the first two subprojects will directly feed into subproject 3, where a European registry and biobank for patients with rare Mendelian forms of PD will be established in order to advance investigations of biomarkers.
MEFOPA is funded through the European Union Seventh Framework Programme under Project No. 241791. The European Commission contribution is €6 million.
Points of Contact
Thomas Gasser
Project Management
University of Tübingen
Department of Medical Genetics
Calwerstr. 7
72076 Tübingen
phone: +49-7071-2972285
fax: +49-7071-295228
email: firstname.lastname@example.com
Sponsors & Partners
Biomedical Research Foundation of the Academy of Athens
CSS-Mendel Institute Rome
Fundació Privada Clinic per a la Recerca Biomèdica
Fundación Ilundain, San Sebastián
Institut National de la Sante et de la Recherche Medicale (INSERM)
Instituto de Medicina Molecular Lisbon
Katholieke Universiteit Leuven
Lund University
Nation and Kapodistrian University of Athens
Novartis AG
Semmelweis University Budapest, Hungary
The Chancellor, Masters and Scholars of the University of Cambridge
Trophos S.A.
United Arab Emirates University, Faculty of Medicine and Health Science
University College London
University Hospital Oslo
University of Aarhus
University of Luebeck
University of Sheffield
University of Tuebingen
Vrije Universiteit: Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patientenzorg


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The Slow Food movement has named Ludlow in Shropshire as the location for its UK headquarters, beating applications from Edinburgh, Cumbria and the Highlands.
Despite having an international network of 83,000 members worldwide, this will be the first time that the movement has had a base in the UK.
It is now almost 20 years since the movement's original conception when a group of outraged Italian gourmets, led by journalist Carlo Petrini, protested against the opening of a McDonalds in Rome.
Today it has grown into an international network dedicated to revolutionising the way people eat and farm around the world.
Sue Miller, Chair of the Slow Food UK's board, identified Ludlow's environmental credentials and extensive range of local food and drink production as the deciding factor.
'We felt that Ludlow was the spiritual home of Slow Food and would provide the ideal base from which to work for a high quality, responsible food culture in the UK.'
The quiet market town, four hours from London, has gained a reputation as one of the UK's centre's of gastronomic excellence.
At least seven of its restaurants feature in the Michelin Guide, including the two-starred Claude Bosi's Hibiscus, and the one-starred Mr Underhill's. The Merchant House, a former Decanter Restaurant of the Year, recently closed by its owner Shaun Hill, also had a Michelin star and is credited with putting Ludlow on the gastronomic map.
Ludlow was also the first UK outpost for the Cittàslow (Italian for 'slow city'), another organisation of Italian origin but with the aim of improving quality of life and avoiding 'the "sameness" that afflicts towns in the modern world'.
Written by Libby Banks


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Arty joins forces with fellow Russians Mattise & Sadko to bring us "Trio," a song undoubtedly deserving of Dancing Astronaut's Anthem Status. This track glows with positive energy from start to finish and was a stand out track both on Arty's Essential Mix and Swedish House Mafia's BBC1 Takeover. Like "Mozart" before it, "Trio" is a delicately balanced combination of trance and progressive that is so massive that it rises above its peers, dwarfing them all in comparison. Expect to hear this one at all of this summer's upcoming festivals and be sure to catch Arty at the Dancing Astronaut stage at No Sugar Added in Miami.
For such a young guy, Arty has been casting one hell of a shadow.
Purchase: Beatport
Categories: Music


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Sometimes I feel like I'm the only one in the world who doesn't own a dog. So let me set the record straight. I'm normal.
According to the best data available, Connecticut ranks 49th out of 50 states in terms of dog ownership, with only 28.3 percent of households owning a dog in 2011. And the trend is down. In 2006, the last year comparable data were available, our state ranked higher, at 47th with an ownership rate of 28.9 percent.
These facts and quotes come from a recent compendium titled "U.S. Pet Ownership & Demographics Sourcebook (2012)," published by the American Veterinary Medical Association to ensure best practices. Founded in 1863, the association represents more than 84,000 veterinarians and acts as a "collective voice for its membership and for the profession." The report was based on a survey of more than 50,000 U.S. households.
In no state does a majority of households own a dog, not even top-ranked Arkansas with 47.9 percent. Ranking dead last among states is Massachusetts, with only 23.6 percent of households owning dogs. The District of Columbia is even lower, with only 13.1 percent of households owning a dog.
Being curious about these numbers, I compared the statistics for dog ownership to the statistics for educational attainment reported by the U.S. Census Bureau. I discovered that Arkansas ranks dead last in terms of educational attainment when measured by the percentage of population with a graduate degree. Only 6.1 percent met the criteria in 2009, the last year for which I could find data. The top-ranked state was Massachusetts, with 16.4 percent. In the District of Columbia, a whopping 28.0 percent of the population had an advanced degree.
These, of course, are statewide averages. There are plenty of dog-owning professionals in the most rural parts of Arkansas, and plenty of non-dog-owning high school dropouts walking the urbanized banks of the Charles River by Harvard and MIT in Cambridge, Mass.
Nevertheless, the correlation between dog ownership and lack of advanced degrees is nearly perfect. Of course everyone knows that correlation and causality are not the same. Darkness doesn't cause sleep any more than dog ownership limits your education, and vice versa. Not being a statistician, social scientist, veterinarian or pet owner, and not wishing to infuriate my readers, I'll disqualify myself from attempting the obvious explanation.
Cats are even more popular than dogs. In top-ranked Vermont, 49.5 percent households own one or more. Dead last is Utah at 24.6 percent. Utah, of course, is a red state: Republican across the board, based on voter registration, the 2012 presidential election, the present governor, the majority of the upper and lower houses, the senior and junior U.S. senators, and the U.S. House delegation. Vermont is a blue state: Democratic across the board, except for Bernie Sanders, the nation's only independent socialist senator.
As before, correlation and causality are not the same. But I can't help speculating that if the cats could vote, we would all be living in a socialist country. And if dogs could vote, they would abolish student loans for graduate school. What does this say about households with both cats and dogs?
The notion of dogs and cats voting isn't that far-fetched because most pets are adults, and more than six out of 10 pet owners "considered their pets to be family members." This fact, reported by the AMVA on the website devoted to the sourcebook, raises the disarming conclusion that these owners must also believe that it's OK to buy and sell members of their family. I see no way around this logic. Do the math. If A=B and B=C, then A=C.
Some owners must also feel OK about lending their family members to help strangers. Consider the now-popular University of Connecticut library program that lends 20 to 25 "stress dogs" to students during final exams week each semester to help relieve their anxiety. This clearly works for some human students. But at what ethical cost to the other species?
Robert M. Thorson is a professor of geology at the University of Connecticut's College of Liberal Arts and Sciences. His column appears every other Thursday. He can be reached at email@example.com.


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150+ Courses, Vignettes, and Games
TeachPrivacy was founded by Professor Daniel J. Solove, the leading expert on privacy and data security law. He is deeply involved in the creation of all training programs because he believes that training works best when made by subject-matter experts and by people with extensive teaching experience.
Please fill in the information below and an associate will send you our catalog via email. We can also provide you with a login so you can evaluate any of our privacy and data security awareness training.


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Texas Longhorn wide receiver Mike Davis deserves suspension after cheap shot block
October 7, 2013
Mike Davis played injured on Thursday night against Iowa State. He battled through a painful ankle injury, caused a mismatch every down and had a good game with six catches for 64 yards. Yet, none of that matters after his blatant cheap shot during the third quarter.
On an easy Joe Bergeron touchdown with 4:30 remaining in the third, Davis went for a block in the end zone, well away from the play, taking out the knees of Cyclone defensive back Deon Broomfield.
It was dirty, unnecessary and blatant, a play deserving of a one-game suspension — something Texas should enforce.
That won't happen, of course. The Big 12 handed down its punishment to Davis on Saturday in the form of a written reprimand from Big 12 commissioner Bob Bowlsby, essentially a verbal scolding from an upset parent — an angry wag of the finger.
Still, that's more than Davis received from head coach Mack Brown after the game. Brown defended his senior wideout.
"He couldn't hear (the whistle)," Brown said. "There's 70,000 people screaming their guts out."
Monday, Davis did show some remorse for the block. Nonetheless, Davis said if the same situation came up again, he'd repeat his actions.
"If the DB's loafing, he deserves to get cut," Davis said. "I think people blew it out of proportion. They took it too far."
Players are taught to play to the whistle from youth football, but they are not instructed to block in such an egregious fashion. Davis' block went straight at the knees of Broomfield, there was no effort to square up and push him in the chest or even a glance at the shoulder pads. Davis attacked the weakest body part of the player who had pushed and banged him around the entire contest.
In addition to his comments Monday, Davis went on a Twitter rant following the game, shielding his actions.
"I don't have a history of being a dirty player and have never been called one," Davis said. "The tape without knowledge of the circumstances is unfair."
"The play call was an option to either a run or WR screen," Davis said. "My job is to protect our WR screen & block my defender. I wasn't aware it was."
"I wasn't aware it was a run," Davis said. "Check the tape and you can see our other WR is also blocking his defender. I did exactly what we are taught to."
But if you check the film, Davis' block came well away from the play, and while he did have his head down, the running back's dive wouldn't have been affected by Broomfield working off his block. Davis never looked up at the play, just went straight at the knees, and, thankfully, Broomfield escaped without an injury.
Davis' block is more at home in the realm of World Wrestling Entertainment instead of the college football field. Actually, it looked remarkably similar to the block for which Ndamukong Suh — widely considered the NFL's dirtiest player — was fined $100,000 earlier this season.
A fine isn't an option in college football, as a suspension is the only way to ensure the message is received. Illegal hits with the potential to end careers cannot be tolerated. If integrity is important to Brown and he wants to enforce that lesson, a suspension is the only option.
It would be tough to lose his most dangerous weapon for the imperative game on the Longhorn schedule, but future player safety and the development of character is paramount.
Davis is not a dirty or a malicious player, but his actions deserve more than a statement of disappointment because Broomfield sums it up best.
"Mike Davis really tried to take me out," Broomfield said.


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The last day of my girl's trip ended amazing, because I got to see my quarter sister Stephanie. Before seeing her, I met up with my coach Susan for some physical therapy and lunch.
Single leg balance on the bosu ball
Double leg squat on the bosu ball
Coach Susan and I after lunch on Coronado Island
Stephanie and I at dinner
The trip was short, but totally worth it! It was nice to be able to go by myself and do all of the things I needed to do daily for my physical therapy. I was under no pressure to walk around and do things that I couldn't do, so I stayed off of my feet for most of the trip. (Minus most of my pictures, of course!) I could live in San Diego. I can't wait to go back when I am all healed up so I can bike around, go surfing (learn to surf, lol!) and best of all, go on some nice runs.
I went back to work today, and it was SO good to be back! I am definitely hurting now and sitting on some ice. My team has been amazing just in one day at keeping me off my feet as much as possible. If you guys are reading this, you are ALL amazing! The pharmacy looked fantastic when I got there today! Thank you from the bottom of my heart for taking such great care of 4422 while I was out.
I am getting a second opinion from an orthopedic surgeon on Wednesday, because I am really nervous about how little progress I have made over the last 9 weeks. I need some objective evidence as to what the hell is going on with my body. I will keep everyone posted.
Have a wonderful week!!
Happy Trails,


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This is the first day of the work week for Canadians so instead of Moanday Links Storm we are having a Bluesday Link Storm!
If you are looking for unique fitness clothing, shoes, fitness equipment, music, nutrition and food or new exercise ideas you may want to go to the CanFit Pro Consumer Fitness and Wellness show at the Metro Toronto Convention Centre on Saturday, August 18th from 8:30AM to 5:30PM for free. Just follow the link below and on the upper right it says Free Ticket. Fill out the form and bring it with you to the show. I have been in the past and had a great time. I was in love with the yoga wear on sale. Sorry they generally only go up to size large. The fitness and dance demonstrations are amazing. You can participate in the demonstrations just be aware that most people that are at this event are fitness pros so they are going to be able to follow along with little instruction. There is a lot of fitness equipment to try on for size and talks by your favorite fitness personalities.
The Huffington Post has a great on-line series of article called Becoming Fearless.
The Huffington Post also has a series called Sleep and another called GPS for the Soul


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Thousands of overwhelmed fans mourning the death of Kobe Bryant gathered Sunday, Jan. 26, outside Staples Center and LA Live in downtown, despite police asking them to to stay away from the venue, which was closed to the public as it hosts the Grammys award show.
The chant,"Kobe-Kobe-Kobe" could be heard from the gathering crowd as a floral arrangement was carried through the throng in the afternoon.
The center is home to the Los Angeles Lakers, and the likely place to gather after news that basketball great Bryant, 41, his 13-year-old daughter Gianna, and seven others were killed in a helicopter crash Sunday morning on a remote hillside in Calabasas.
Bryant, an 18-time All-Star and five-time NBA champion, played his entire 20-year career with the Lakers.
One longtime Bryant fan, who was on his way to downtown to join the throng of other mourners, lamented the tragic loss Sunday of the NBA All-Star.
"After 10 years of trying we finally got a picture with Kobe," said Jessie Avila, a resident of North Hollywood. "I used it to teach my son to never give up on your dreams."
The crowd continued to grow, even as the Grammy Award nominees and show attendees arrived to the red carpet.
Near the scene of the crash in Calabasas, authorities were directing mourners to the area of Lost Hills and Las Virgenes roads, at Juan Batista de Anza Park in Calabasas.
MAP: The route of the helicopter flight
There, fan Ian Smith remembered being at the parade when the Lakers won their first of back-to-back championships with Bryant under Phil Jackson in 1999. "It was like the Pope was here." Smith, 28, was inspired to star playing basketball that year, like many others in Los Angeles.
"People's hearts are broken," said Calabasas Mayor Alicia Weintraub before the first mourners arrived at the park. "I think its impacted everyone. I mean, Kobe Bryant was an institution."
Fans also gathered at Bryant's Mamba Sports Academy in Newbury Park. TMZ reported those aboard the helicopter were en route there for a basketball practice when the crash occurred.
The Grammy pre-telecast ceremony, where most of the awards are handed out, opened with a brief remembrance of NBA star Bryant, who was killed earlier in the day in a helicopter crash in California.
Referring to the arena where Bryant played for the LA Lakers, Interim Recording Academy CEO Harvey Mason Jr. said, "Since we are in his house, I would ask you to join me in a moment of silence."
Staff writers Eric Licas and Mindy Schauer and The Associated Press contributed to this report.
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Staff Biographies
The following staff members have specialized knowledge in their fields. Click on the links to access their curricula vitae.
Karen Christianson
Karen Christianson is Director of Public Engagement. She holds a PhD in history from the University of Iowa, and she has taught at DePaul University and Chicago State University. Her research interests include medieval monasticism, gender, and power; manuscript studies; and the digital humanities. She also has a background in journalism and communications.
Daniel Greene
Daniel Greene became the President and Librarian at the Newberry Library in 2019. He is also an Adjunct Professor of History at Northwestern University. Prior to arriving at the Newberry, Greene curated Americans and the Holocaust, an exhibition that opened in April 2018 at the U.S. Holocaust Memorial Museum in Washington, DC. His book The Jewish Origins of Cultural Pluralism: The Menorah Association and American Diversity (Indiana University Press, 2011) won the American Jewish Historical Society's Saul Viener Prize in American Jewish history in 2012. He's also the co-author of Home Front: Daily Life in the Civil War North (University of Chicago, 2013), which accompanied a co-organized exhibition between the Newberry and the Terra Foundation for American Art. Greene has been a Distinguished Lecturer for the Organization of American Historians since 2015. He earned his PhD in history at the University of Chicago.
Will Hansen
In his dual role as Director of Reader Services and Curator of Americana, Will Hansen manages the Department of Reader Services, which serves researchers at the reference desks, in the reading rooms, and outside the Newberry's walls via email and other communications, while also managing the library's collections in the 10-floor book stack building; as Curator of Americana he collects current monographs, antiquarian books, and manuscript Americana for the Newberry. He also facilitates and conducts bibliographic instruction, tours and orientations for visiting groups, classes, and fellows. Mr. Hansen began his career in libraries at the Newberry in 2003 as a Circulation Assistant and then, in 2004, as the library's Reference Assistant. He holds a master's degree in library and information science from the University of Illinois at Urbana-Champaign and a bachelor's degree in English from the University of Nebraska-Lincoln. From 2007 to May 2014 he was Assistant Curator of Collections at Duke University's David M. Rubenstein Rare Book & Manuscript Library, and returned to the Newberry in June 2014.
Lia Markey
Lia Markey (PhD Art History, University of Chicago) is the Director of the Center for Renaissance Studies and Affiliate Faculty in the Department of Art History at Northwestern University. She has taught at the University of Pennsylvania and at Princeton University and held post-doctoral fellowships at the Folger Library, the Warburg Institute, Harvard's Villa I Tatti, and the Metropolitan Museum of Art. Her research explores cross-cultural exchange between Italy and the Americas in the sixteenth century, collecting history, and early modern prints and drawings. Most recently, she has published Imagining the Americas in Medici Florence (Penn State University Press, 2016) and a co-edited volume, The New World in Early Modern Italy, 1492-1750 (Cambridge University Press, 2017).
Rose Miron
Rose Miron is the Director of the D'Arcy McNickle Center for American Indian and Indigenous Studies and Affiliate Faculty in the Center for Native American and Indigenous Research at Northwestern University. She holds a BA in History and a PhD in American Studies from the University of Minnesota. Her research explores Indigenous public history and public memory within the Northeast and the Great Lakes regions, and her manuscript project, "Indigenous Archival Activism: Reclaiming Native History in the Mohican Tribal Archive and Beyond" is under contract with University of Minnesota Press. The project is based in close collaboration with the Stockbridge-Munsee Mohican Nation since 2011 and explores Indigenous interventions in archives as types of Indigenous activism and nation-building. Dr. Miron has also worked on and written about several public history projects ranging on topics from the US Dakota War to Indigenous representations in monuments. Her work has been published by the journal Native American and Indigenous Studies, Routledge Press, and the National Council on Public History.
Liesl Olson
Liesl Olson is Director of Chicago Studies at the Newberry. Her research interests include twentieth-century literature, modernism, critical theory, feminism, and the visual arts. She is the author of Chicago Renaissance: The Midwest and Modernism (Yale U P, 2017), a history of the literary and cultural centrality of Chicago in the first half of the twentieth century; and Modernism and the Ordinary (Oxford U P, 2009), which examines a broad range of twentieth-century works that represent the habitual and unselfconscious actions of everyday life. From 2005-2009 Olson taught at the University of Chicago as a Harper-Schmidt Fellow in the Humanities Division. She has received fellowships from the National Endowment for the Humanities, the Newberry, and the American Council of Learned Societies. Olson completed her doctorate in English and Comparative Literature from Columbia University, and her BA from Stanford University.
Matt Rutherford
Matt Rutherford, MLIS, is Curator of Genealogy and Local History at the Newberry. In addition to managing the Newberry's renowned genealogy collection, Matt has also answered thousands of questions on a wide range of genealogy topics. He has spoken at the Illinois State Genealogical Society and the Conference on Illinois History, as well as several local genealogy societies, including the North Suburban Genealogical Society, the Genealogical Forum of Elmhurst, and the Illinois St. Andrew Society. In addition, Matt teaches seminars on a variety of genealogy topics, including beginning genealogy, researching at the Newberry, researching pre-fire Chicago, adoption searches, non-population census schedules, the history of the federal census, and the Social Security Death Index. He is the co-author of A Bibliography of African American History at the Newberry Library (2005)
Alice Schreyer
Alice Schreyer (PhD, Emory University; MLIS, Columbia University) is Roger and Julie Baskes Vice President for Collections and Library Services at the Newberry. She was previously Associate University Librarian for Area Studies and Special Collections at the University of Chicago Library, where she was director of the Special Collections Research Center from 1991 through 2011. As a member of the ARL Task Force on Special Collections, she wrote "Education and Training for Careers in Special Collections Librarianship: A White Paper" (2004). Her talk, "Everything Old Is New Again: Transformation in Special Collections," presented at the 2015 colloquium on "Forging the Future of Special Collections," was published in a collection with the same name (Chicago: ALA Neal Schuman, 2016). Schreyer served on the Rare Book School Board of Directors from 2004 to 2016 and was chair from January 2014 through January 2016.
Jennifer Thom Dalzin
Jennifer Thom Dalzin is the Director of Digital Initiatives and Services. She focuses on library special collections, digital-project management, and digital strategy. Dalzin arrived at the Newberry in 2003, managing the Retrospective Conversion Project (to put information from more than 650,000 catalog cards online) and several other large-scale cataloging projects including the Roger S. Baskes Collection; the McCormick Theological Seminary Collection; the Sister Ann Ida Gannon Initiative; and the French pamphlet project, which was funded by the Council on Library and Information Resources. Before coming to the Newberry, Dalzin was the Development Administrator and later the Curator of Photography/Digital Projects Manager at the Western History/Genealogy Department at the Denver Public Library. Prior to moving to Denver, she was the Director of the Albert J. Zak Memorial Library in Hamtramck, Michigan. Dalzin holds a master's degree in library sciences and a bachelor's degree in Medieval studies from the University of Michigan.
Jen Wolfe
Jen Wolfe (MLIS, University of Washington) is the Digital Initiatives Manager at the Newberry. Before joining the Newberry in 2015, she was a librarian at Seattle's Museum of Pop Culture, and at the University of Iowa Libraries. Her publications include "DIY History: Redesigning a Platform for a Transcription Crowdsourcing Initiative," in Outreach: Innovative Practices for Archives and Special Collections (Rowman & Littlefield: 2014); "Playing Fast and Loose With the Rules: Metadata Cataloging for Digital Library Projects," in Radical Cataloging: Essays at the Front (McFarland: 2008); and "Career novels," "Romance comics," "Zines," inGirl Culture: An Encyclopedia (Greenwood Press: 2007). She has presented on digital public history, cultural heritage crowdsourcing, and digital pedagogy at numerous conferences, including the Midwest Archives Conference, Women's History in a Digital World, Penn Digital Humanities Forum Symposium, DLF Forum, and Museums and the Web. In 2013, she won the Center for Research Libraries Primary Source Award for Access.


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What happens if my patent application is granted?
Once an examiner at the PTO decides to grant a patent, a Notice of Allowance and Issue Fee is mailed to the inventor. This notice notifies the inventor that his patent application has been accepted and informs the inventor what additional fees are owed - the inventor has three months from the mailing date to submit the required fees. After it mails this notice, the PTO prepares an electronic version of the inventor's patent and gets ready to issue the patent. The PTO then mails an Issue Notification to the inventor, and follows this by mailing the patent grant to the inventor. This patent grant, which is bound and includes a gold seal and red ribbon on its cover, includes information about the patent including any related prior patents, an identification of the patent, and the patent's specification and claims.
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Bernard Chang Criticises Valiant On Rai Flag Choice
Bernard Chang has been criticising Valiant for their choice of design on the new Rai character being relaunched by Matt Kindt and Clayton Crain. On Facebook, according to these scans sent to Bleeding Cool, he posted,
It's not the only target to be criticised for using the Rising Sun flag, often from those with a Chinese or Korean background, after occupation during World War II. It is associated with war crimes, imperialism and more. Music Core came under similar criticism, so has the band Tara N4,


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$500,000 settlement reached in Herkimer Co. inmate's death
Herkimer County and Little Falls Hospital agreed to settle for $500,000 Tuesday in connection to the 2006 death of an inmate at the county jail who overdosed after being prescribed a dangerous level of medication.
After only three witnesses testified in a federal trial that began Monday in U.S. District Court, a settlement was reached by the county and the hospital to pay $250,000 each to the estate of Michael DiCamillo, which is represented by his brother Matthew Gabriel.
Among the defendants was nurse practitioner Charlene Macri, an employee of Little Falls Hospital at the time who had been contracted to do medical care at the jail while DiCamillo was incarcerated.
She is now working directly for Herkimer County as a nurse practitioner at the jail.
Although a report by the state Commission of Correction concluded in 2007 DiCamillo's drug-related death was partly the result of jail medical staff who failed to recognize signs of medication overdose, Herkimer County Sheriff Christopher Farber on Tuesday said the settlement did not require anybody to admit any wrongdoing. Farber, however, would not say whether any lessons were learned or policies changed at the jail as a result of DiCamillo's death.
"We're always changing policy and procedures, but the case was basically resolved during trial without any finding of any wrongdoing by any of the parties," Farber said. "We didn't do anything wrong. We learn lessons everyday. We find things that we could do better that we change on our own, but until our attorneys are done with everything, I'm done commenting."
According to the state Commission of Correction, DiCamillo, 38, of Utica, died June 30, 2006, while incarcerated at the jail as a result of heart complications caused by toxic levels of the antidepressant Venlafaxine. In their findings, the commission attributes DiCamillo's death to a community psychiatrist — who is not identified by name — who prescribed a dangerous level of medication and then failed to adequately monitor his use. As far as Herkimer County is concerned, the commission also states "DiCamillo's death could have been prevented had proper medical intervention been provided when he began showing signs of acute intoxication" while he was jailed.
Neither Gabriel's attorney, Elmer Keach III, nor the attorneys for Herkimer County and Macri — Thomas Murphy and Joseph Perkins, respectively — could be reached for comment Tuesday.
The case was heard by U.S. District Judge David N. Hurd.
DiCamillo — who had a history of health problems and a lengthy list of prescribed medications — was first incarcerated at the county jail on June 23, 2006, after being charged with resisting arrest. Signs of drug intoxication soon became apparent in the seven days leading up to DiCamillo's death, court documents state. He would sweat profusely and could barely keep his eyes open while sitting on the floor, the lawsuit states. Other times he couldn't walk and would fall down, with occasional drooling, loss of consciousness and confusion. His drug intoxication was further compounded, the lawsuit states, as jail personnel failed to give DiCamillo his medication at proper intervals and instead forced him to take all of his medication at one time, once a day.
Several hours before DiCamillo died, he attempted to get up that morning and fell, documents state. A correction officer informed Macri of this incident, but instead of directly evaluating DiCamillo she ordered that one of his medications be discontinued until further notice.
"Correction officers are not qualified to perform such assessments and cannot interpret medical data for a qualified clinician," the commission's 2007 report states.
By 3:55 p.m. that day, a correction found DiCamillo lying dead on the floor of his cell.
In its final recommendations, the commission suggested the sheriff's office "immediately discontinue" the practice of using officers to conduct medical assessments and interpretations that only registered nurses are permitted to do.
The commission also suggested the state Department of Health investigate the community psychiatrist who treated DiCamillo before he was incarcerated.
Finally, the commission recommended the state Education Department's Office of Professional Discipline investigate the nurses who failed to make the jail's physician aware of DiCamillo's many prescriptions and who failed to recognize DiCamillo's obvious signs of drug intoxication.


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Everglades National Park: 5 reasons you should visit this Florida park
It's hot outside, people! But it's also August, which is a month for celebrating Florida's national parks. Why? Because August 25 marks the 103rd birthday of the National Park Service. It's a great reason to visit one of the state's most cherished spots, Everglades National Park.
Everglades National Park is the largest subtropical wilderness in the United States, with 1.5 million acres of wetland. That's more than 2,300 square miles. This gigantic wetland is a natural habitat for thousands of alligators, snakes, birds, the Florida panther and other wild creatures. It's sad that Floridians aren't rushing to see it at least once in their lifetime.
There's so much to see and do, so make it a day trip!
Every season, enjoy several events and tours at the park for free simply by paying the entrance fee. This doesn't include any camping or equipment rentals. Check the park's website for more information on admission prices and fees.
If you plan to visit, check the 'Alert' area on the park's website for safety alerts and warnings. It's best to know of precautions before you plan your trip. And since we're talking about national parks, Yosemite National Park in California is one you should do too. It might be a bit far from Florida, but we did it for under $500.
1. History
This shallow, slow-moving sheet of water covered almost 11,000 square miles for thousands of years — then humans came around.
By the 1900s, people started turning the wetland to dry land in order to build farms and cities such as Miami and Fort Lauderdale. Everglades National Park was established in 1947 to conserve and protect the natural landscape and prevent further damage to the land, plants and animals.
The Everglades is also home to the Nike Missile launch site, an abandoned missile site. Learn more about the Everglades National Park history.
2. See wild animals
The Everglades is home to many animals that have adapted to the tropical wetland. The park's swamps are a mixture of both sweet and saltwater. Some of the threatened animals living at the park include the Florida panther, American crocodile, American alligator, West Indian manatee, wood stork, and snail kite. You can also see turtles, dolphins, snakes and more.
Here's the checklist to some of the animals you can encounter.
3. Outdoor Explorations
The park offers an endless list of outdoor activities. Biking through the trails, hiking, bird watching, camping, boating, canoeing, kayaking and fishing are just a few of them. Many people take science workshops and guided tours or volunteer to learn more about the ecosystem and nature of the park.
When you go, don't forget to plan a stop by 'Robert Is Here', the Disney World of fruit stands.
4. Thrilling boat rides
You can't come to the Everglades and not take a boat tour (and then not post it on social media). So be sure you to plan ahead of time and make all the calls prior to your arrival. Things can get booked completely, so you'll want to reserve your spot.
An airboat tour through the Everglades is a fast way to see a lot of the park in a short amount of time. You'll go through narrow canals and open water areas, and you'll see animals in their natural habitat.
5. Alligator Heaven
Whether you're from Florida or not, seeing a wild alligator is a thrilling experience. And to see these creatures hunt and feed in person is quite a scary show. The Everglades is the only place on Earth where alligators and crocodiles coexist.
- Visit the Everglades National Park website and call to verify if the visitor centers, hiking trails and rest stops are open before your trip.
- Check the weather before you do anything. This area is extremely seasonal and water can rise. You don't want to be stuck in the middle of The Everglades.
- If going on a wet walk (water can be waist high), it is recommended that you have a hiking stick to poke the trail ahead of you, wear your regular tennis shoes since high boots would fill with water and become too heavy to walk in and have plenty of Zip-loc bags for your stuff.
- If hiking during hunting season, wear a lightweight, blaze-orange vest. You can buy these at any sporting goods store. The last thing you want is to get hunted.
- Besides the obvious of not littering, don't throw away any fruits or vegetables that aren't native to the area. The Everglades already has enough non-native plants and species damaging the natural ecosystem. It doesn't need more, so don't throw away your apple, avocado or whatever you're snacking on.
View this post on Instagram
Last weekend's wet hike was a success! A big thanks to everyone who came out to enjoy the wetter side of the Everglades and to celebrate Latino Conservation Week! NPS Photos #EvergladesNationalPark #LatinoConservationWeek #FindYourPark
A post shared by Everglades National Park (@evergladesnps) on
If you go: Call to make sure which entrance is open and near you, and to check on any weather or natural disaster status. Free tours and free days change every year. Call before you arrive.
The Everglades National Park: 40001 State Road 9336, Homestead; 305-242-7700. www.nps.gov/ever/index.htm
For more Florida trips and adventures, sign up for the free weekly newsletter, Day Trippin'.


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Great Things Come In 3
Danco Version 3.0 is here!
We are very excited to announce that our website has been given a bit of a facelift in the last week or so. Some of you may have noticed already. We had been working out some bugs and we think we got them all but if you find one feel free to let us know.
DANCO 3.0 Has a Ton of New Features:
- Persistent Shopping Cart: saves your cart contents across sessions and multiple visits to the site.
- Better Search Functionality: a lot easier to find what you are looking for.
- Responsive Design: the site will resize to your device of choice (as seen above).
- Cleaner and Bigger Layout: larger much clearer product images and text.
- Updated My Account Area: Cleaner and easier than ever to find past orders and tracking information.
- & Much Much More
In the end we wanted Danco 3.0 to serve you better. Please do not hesitate to let us know if you have problems with our new website.


text: Supplementary Materials Supporting Information supp_294_14_5576__index. HIV proteins expression induced by SAHA were killed by cytotoxic T lymphocytes (5, 6), reduction in the size of the latent reservoir following administration of SAHA was not observed (2, 3). Another HDACi, romidepsin (RMD) appeared to be more potent than SAHA for reactivating HIV (7); however, administration of RMD alone did not result in a reduction of the latent reservoir (4). A more recent clinical trial using a combined treatment strategy of RMD with Vacc-4x, recombinant human granulocyte macrophage colonyCstimulating factor vaccination, reported a reduction of the reservoir 6 weeks after RMD administration (8). This reduction in reservoir size was, however, not statistically significant (8). By interfering with the active site of HDAC enzymes, HDACis trigger hyperacetylation of chromatin and histones relaxation. HDAC classification into four specific classes is dependant on homology to fungus acetylases. HDACs from classes I, II, and IV are Zn2+-reliant enzymes, whereas course III HDACs, known as sirtuins, are NAD+-reliant (evaluated in Ref. 9). The HDACis, found in surprise and kill ways of reactivate latent HIV, inhibit HDACs AX-024 hydrochloride of classes I, II, and IV by chelating Zn2+ ions or getting covalently linked on the AX-024 hydrochloride energetic site (evaluated in Ref. 9), with different specificities and potencies (7, 10). Several HDACis have a wide range of actions (known as AX-024 hydrochloride pan-HDACis); nevertheless, the IC50 beliefs of different HDACs vary. For instance, SAHA is dynamic against consultant HDACs from classes I, II, and IV; nevertheless, it is strongest against HDAC6, a representative of course II (7). On the other hand, RMD provides high strength against HDACs of course I with suprisingly low activity against HDAC6 (7, 11). Because HDACs of course I have already been implicated in preserving HIV provirus within a latent condition (12,C14), higher strength of RMD for these specific HDACs may describe why it had been more vigorous than SAHA for reactivation of HIV. Despite chromatin rest due to HDACi, gene expressionCprofiling research of cells treated with SAHA determined comparable amounts of up- and down-regulated genes (15,C17). CT96 These results are in keeping with the simple proven fact that substitute systems of gene legislation are induced by SAHA, such as supplementary down-modulation of gene appearance by turned on transcription elements or modulation mediated via non-histone effects (evaluated in Ref. 18). A recently available research by Zaikos (19) confirmed that SAHA induced inhibitory results on HIV reactivation, via its activity against HDAC6 and its own nonhistone goals specifically. RMD exhibited an identical inhibitory behavior on HIV appearance (19), though it provides just marginal activity against HDAC6 (7, 11). Hence, it is plausible the fact that inhibitory aftereffect of RMD on HIV isn't associated with immediate inhibition of HDAC6 activity. Chances are that supplementary effects on web host gene appearance following preliminary gene activation enjoy an important function in the web achievable degree of induction of HIV gene appearance pursuing treatment with HDACi. We've previously proven that a few of these supplementary effects regarding SAHA symbolized down-regulation of HIV transcriptional activators and up-regulation of repressors, both on the RNA and proteins levels (20). Today's study was performed to measure the aftereffect of RMD in the transcriptome of major uninfected Compact disc4+ T cells and an style of HIV latency also to compare the consequences of RMD and SAHA on web host genes to improve our knowledge of the supplementary mechanism of actions of these substances that are highly relevant to reactivation of latent HIV. A subset of web host genes modulated by both of these HDACis were assessed as potential targets for improving shock and kill treatment outcomes. Results Choice of HDACi doses and verification of activity Treatment with 1 m SAHA has been shown previously to result in induction of expression of HIV RNA in the Spina model of HIV latency (21) that was used in the present study. Here, we have tested the activity of RMD for HIV reactivation in the same model system. To determine the.


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I was going to write a big post on HP and WebOS. I was working away on a 'What now for WebOS?' post … until I caught the news that this, too, was dead. Here's PC World's overview: HP's WebOS crashes under Apple, Android Pressure.
Goodness me it's been quite a week for big movements.
Robert Scoble neatly summed up HP's news thus:
Windows 8 wins
Oh, HP, kills TouchPad after only a month in market
The third party developers are in charge.
No apps, no sales.
I think this is the (very costly) new reality for manufacturers.
Scoble also points out something I think we've known for quite sometime — developers are only thinking about 3-4 platforms, period. That's it. No more. He quotes one leading developer thus:
Developers like him keep telling me "Apple is first in my mind, Google is second, and I don't have time for #3, but if I do, looks like Microsoft has the best future."
For Microsoft read Nokia. Nokia's made themselves business critical to Microsoft's success in the mobile ecosystem. Although Scoble is no doubt operating under a highly polarised Silicon Valley viewpoint, it's a viewpoint that's increasingly becoming de facto across the Western world. Once America got control of the mobile ecosystem, it was game-over for anyone else not willing or capable of innovating at the same pace.
The legions of Symbian fanatics who still passionately hate Nokia's Stephen Elop may come to see a different point of view when Nokia is growing firmly under Windows.
But dear me, what about HP? What a way to screw it up, gents.
I really did buy the HP koolaid. I was hoping for a bit of a fight from them. I was hoping for some decent corporate venturing to challenge the status quo. There's no doubting that WebOS
is was phenomenally nice. I did enjoy playing with the tablet back in Barcelona. Back in March I remember meeting the enormously charasmatic Richard Kerris, who headed up WebOS developer relations, who explained that HP was aiming to have 100 million WebOS devices in the market by the end of 2011 (mostly through integrating it into printers and also adding support for the desktop).
Here's what I commented back then:
A hundred million devices? That's easily achievable if you assume some nice healthy Palm device sales and you include most of the company's consumer desktop/laptop and printer sales.
I bought the concept, though. I was sitting back and waiting though. Unfortunately it seems everyone else — especially the developers — were doing the same thing.
It just goes to show that one quarter can change everything. It was only a few months ago I was in San Diego watching HP's Jon Rubenstein absolutely slate Nokia on stage. Now HP is no more as far as we're all concerned. Apart from the odd printer and scanner (and of course, data centres), they're largely irrelevant to the mobile world now.
I'm frankly embarrassed.
I'm embarrassed that a company with revenues of one hundred and twenty-six BILLION dollars (thanks, Wikipedia) couldn't hack it in the consumer mobile space. It would be laughable if the sad reality wasn't so sobering. Come on, seriously? Is it really that difficult to compete? Or did you ham-string everything from the start with the usual corporate shenanigans?
The new reality of apps-apps-apps is confirmed once more with HP's demise in mobile.
WebOS isn't completely dead though. Not completely. It looks somebody else might be able to license WebOS in future. Don't hold your breath.
Sidenote: What about RIM?
This is the real issue that we're all going to need to deal with shortly. It's one that's been bugging me for quite a while. I have been largely silent as I've been observing the market. I'm such a huge fan of the devices — their latest BlackBerry Bold 9900 is a masterpiece of messaging joy. I worry that they won't be able to escape the Scobleist Reality of apps, apps, apps. How many times do you need folk to say, "RIM is dead," before it starts to become reality? Thankfully RIM is not dead. They're number-one in a gazillion markets — they practically own Latin America's smartphone market. They still continue to shift a massive amount of product. People are still buying their phones. We'll need some good leadership from RIM over the next 3-4 quarters.


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Browse by Eprint ID
Number of items: 1.
Laughlin, K. B. and Blake, Geoffrey A. and Cohen, R. C. et al. (1987) Determination of the dipole moment of ArH+ from the rotational Zeeman effect by tunable far infrared laser spectroscopy. Physical Review Letters, 58 (10). pp. 996-999. ISSN 0031-9007. doi:10.1103/PhysRevLett.58.996. https://resolver.caltech.edu/CaltechAUTHORS:LAUprl87


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Earlier this month Blac Chyna went on a headline making Covid19 vaccine rant inside an airport terminal [click here if you missed that].
Chyna's mom Tokyo Toni explains her daughter's behavior...
We assumed as much.
@11:21 that we did...
She act like her mama.
Mother of the year!!!!
If I had a mom like her I'd get high too!
●The apple didn't fall far from the tree.
●I seriously thought she (Tokyo) had on a Halloween costume until she started talking.
She was involved with a kardashian that's what happens. No one comes out of those relationships normal
Don't blame Rob. Scott Disick is rolling in doe he came out alright.


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Josh R. forwards me this bit of political news. Out in California, there is jockeying for a congressional seat, with Republicans looking to challenge freshman Democrat Julia Brownley, who represents the Ventura County/Oxnard/Thousand Oaks area. Possibilities:
Colusa County Supervisor Kim Vann is likely to challenge Rep. John Garamendi in the Sacramento-area 3rd District. Former state Sen. Tony Strickland is expected to run again, most likely forging a rematch with freshman Rep. Julia Brownley in the Ventura County-based 26th District.
There's some talk that Strickland would take a look at the neighboring 25th District if GOP Rep. Howard "Buck" McKeon opts for retirement. One plugged-in GOP source said another person looking at a challenge to Brownley is baseball pitcher Jeff Suppan, who may run if he doesn't make a Major League roster this season.
Let's see: Suppan got knocked around for six starts with the Padres last season, knocked around while down in Tucson, and was knocked around in a full season in Omaha in 2011. I'm guessing the 38 year-old is free to run for Congress if he feels like it.


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Off-campus UNL users: To download campus access dissertations, please use the following link to log into our proxy server with your NU ID and password. When you are done browsing please remember to return to this page and log out.
Non-UNL users: Please talk to your librarian about requesting this dissertation through interlibrary loan.
Fate and transport of antibiotics in the agroecosystem: Uptake in the soil-plant system
Increasing stress on freshwater supplies, a result of increasing global population and climate change, has made necessary the reuse of wastewater as a source for irrigation. Wastewater, both municipal and agricultural, is a known reservoir for many emerging contaminants (ECs) including antibiotics. The use of wastewater for irrigation provides a pathway for antibiotics to enter the agroecosystem and the surrounding environment. With the emergence of antibiotic resistance as a global human health issue and the increased detection of human pharmaceuticals in various environmental compartments, an increased focus has been placed on the understanding of the fate and transport of these compounds. The focus of this dissertation research was to gain a better understanding of how antibiotic uptake is influenced by the soil-plant system when antibiotics are introduced into the system via irrigation water. Initially, a freeze and thaw cell lysing extraction method was developed and evaluated to extract and quantify four antibiotic compounds (ciprofloxacin, lincomycin, oxytetracycline, and sulfamethoxazole) from water, soil, and complex vegetative matrices. With this, a number of different environmental parameters were examined to determine their impacts on uptake into plants. First, subspecies variation in uptake potential in two cultivars of lettuce, lactuga sativa, revealed significantly higher uptake in cv. Greenstar compared to cv. Salad Bowl. Next, the influence of soil texture and drought conditions on the uptake of antibiotics from a single exposure of contaminated irrigation water showed that both variables impact antibiotic uptake, with the results being compound specific. In a follow up study, the influence of soil texture on antibiotic uptake by lettuce was studied with exposure to contaminated irrigation water throughout the entire growth cycle. Results reinforced the compound specific nature of soil texture effects and also revealed the time dependent nature of the uptake process and the influence of persistence both in soil and in the plant tissue. A final investigation was conducted to identify trends in uptake between various vegetables representing root, shoot, and fruit edible portions and showed distinct species level differences in uptake as well as compound specific differences in accumulation and translocation from various plant portions.
Subject Area
Agriculture|Analytical chemistry|Environmental engineering
Recommended Citation
Sallach, J. Brett, "Fate and transport of antibiotics in the agroecosystem: Uptake in the soil-plant system" (2015). ETD collection for University of Nebraska - Lincoln. AAI3738485.


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- Admin
Welcome to NEW YORK CITY
I returned to the city where it all began to commence our marketing campaign by giving away 6 copies to 6 lucky readers hidden in 6 locations
Seeing the Statue of Liberty as we entered the Big Apple was emotional Life has been like one of my Novel's this last three years and I was excited to finish the year where my dream began.
Jake Cannon
"Its the city that never sleeps and so neither can I, No rest for the wicked right. Well if the Devil dont sleep neither can the Angel of New York."


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During the 1960s, it was sometimes suggested that social rebellion among the younger generation could be blamed on Dr. Spock, the pediatrician and psychologist whose best-selling books on raising children had been a bible to tens of millions of postwar parents. But today it would be impossible to point the finger at any one expert. Bookstore and library shelves are jammed with countless guidebooks dispensing knowledge that for most of human history was passed down from generation to generation, not written down in books.
The first child-rearing guides appeared about a century ago, and now there are so many that a new publishing trend has popped up: books investigating why there are so many parenting books. Some attribute it to "push-parenting" and "paranoid parenting"–terms used to describe a parental style based on controlling all aspects of a child's life. In Raising America: Experts, Parents, and a Century of Advice About Children (Knopf), author Ann Hulbert looks at the modern history of child-rearing advice. Peter N. Stearns covers similar territory in Anxious Parents: A History of Modern Childrearing in America (New York University Press). And these are but two of many recent studies that explore why bringing up baby has become a cradle of so much cultural anxiety.
Reviewing these works in the neoconservative journal Commentary (June 2003), Kay S. Hymowitz notes that "parental angst" is not new, but it does seem more pervasive these days. A century ago, when one of every six children died before the age of 5, parents focused on the more immediate task of keeping children alive. But as medical progress and better infant nutrition lowered childhood mortality rates, parental anxiety began to shift to the "right" ways of raising children. A new cult of experts soon arose promising to extend scientific efficiency to all aspects of child development. But these new scientific authorities were often no more accurate than the earlier "folk" beliefs they replaced. In the early decades of the 20th century, for instance, it was widely accepted that touching children too often stunted their development.
Hymowitz, the author of her own recent book on child rearing, Liberation's Children: Parents and Kids in a Postmodern Age (Ivan Dee), notes that as children's likelihood of surviving to adulthood increased, so did parents' anxiety about how their kids would turn out. And those fears have continued to grow. As dual-income families became more isolated, neighbors became less likely to look out for each other's children, explains Elisabeth Lasch-Quinn in an article on child raising in The Wilson Quarterly (Spring 2003). Supervision suddenly became all-important. The prevalence of child day care, she argues, has changed our parenting focus from nurturing to supervision because "society has embraced day care as a solution to the disjuncture between full-time work, consumerism, and family life." But Lasch-Quinn also acknowledges that there are very real dangers facing children: "Until we can make society more conducive to children's freedom and independence, it hardly seems logical to drop our guard."
Still, it's ironic that in the wealthiest and one of the best-educated countries on earth, parents are so overwhelmed by the responsibilities of raising children and so quick to turn to experts. This pressure is perhaps understandable in light of the American dream, which demands that children must be more successful than their parents. After all, if childhood is now merely a boot camp preparing the young for future accomplishment, parents can be forgiven for believing they need all the expertise they can get their hands on.
But the most important role of parents may not be ensuring that their kids get into the right schools and then find their way to careers in booming fields. Maybe their real job is to raise kids whose worth is ultimately determined by who they are, not by what they earn or own. In considering this possibility, parents may wish to toss aside the child-rearing guides and expand their reading choices to other works that just might deepen their parental skills and insights in unexpected ways.
Anne Geske is a Minneapolis writer.


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That trailer is quite possibly the shortest trailer you will ever see.
If you haven't heard yet, Valkyria Chronicles 2 is coming to the PlayStation Portable. Not much gameplay footage has been shown, but you can check out what little has been released over at their Japanese website.
(Source: Siliconera)


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Turn Undead
Type: Attack spell
Damage Types: Holy: 100%
Maximum Damage: 550
Additional Effects: Yes
Casting time: 3 rounds
Spell cost: 150
Spell level: 11
Spell category: holy
Affecting stats: wisdom
Offensive: Yes
Location: Anywhere
Target: livingtarget
Range: room
Components: VSM
Components: sikkarin cross (1 charge)
Alignment: Must be Good.
With the power of Sikkar on the Cleric's side, he can damage undead beings, cause them to hesitate, stumble backwards in fear, or even disintegrate them.
page revision: 2, last edited: 23 Jun 2008 14:15


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We could all use a SanityCheck.com - Am I right ?
Walking through the second chapter of my life by asking: What can I do for the world? You'll find the answer at http://misstiffanysun.com/about
Blog of the MFA in Interdisciplinary Arts and Writing program at California Institute of Integral Studies in San Francisco, CA, U.S.A.
Scholar, Education Consultant, Social Projects Developer, Branding Consultant.
Non-fiction writing coach loves reading, writing, the Colorado mountains, J. S. Bach and Willa Cather. Get "9 Tips for Readable Writing" at firstname.lastname@example.com


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Proud To Be the Kookiest PBS Station in America--KBDI, Denver
Here's a presser on their upcoming presentation of Press For Truth.
For starters, they use a picture of the Jersey Girls, featuring Kristen Breitweiser in front:
Except that Breitweiser does not appear in the film except in old TV clips, and the other three widows are actually the stars of the show (in addition to Bob McIlvaine).
That photo was used on the DVD cover for PfT, which we covered back in the dog days of 2006, but at least they had the decency to remove Mrs Breitweiser:
Following the attacks of September 11th, a small group of grieving families waged a tenacious battle against those who sought to bury the truth about the event -- including, to their amazement, President Bush. In this documentary, six of them -- including three of the famous 9/11 widows known as the "Jersey Girls" -- tell the powerful story of how they took on the greatest powers in Washington, compelling lawmakers to launch an investigation that ultimately failed to answer most of their questions. The filmmakers collaborated with the media group Globalvision (WMD: Weapons of Mass Deception, Beyond JFK) to stitch together overlooked news clips, buried stories, and government press conferences, revealing a pattern of official lies, deception, and spin. As a result, a very different picture of 9/11 emerges -- one that raises new, and more pressing, questions.
And if you pledge $104 to these Rocky Mountain Oysters, you'll get a DVD of PfT plus In Their Own Words, all the crappy questions that they had to pull out of PfT because they were even more ridiculous and embarrassing than the ones they left in.
But wait, there's more! If you send another $50, we'll send you David Ray Grifter's The New Pearl Harbor! Oh, we can tell that KBDI is an exemplary PBS network, representing the Rocky Mountain spotted feverish contingent proudly.
And if you are delusional enough to part with 304 bones to the nutbar network, you could actually get 5 DVDs plus two books. The added DVDs are Blueprint for Truth by Box Boy Gage, Fabled Enemas by Bermas, and a DRG lecture from 2007. Why mention the added book (a Peter Dale Scott snoozer), nobody's going to read it.
What a sad, pathetic little station KBDI is.
Labels: KBDI, PBS, Press for Truth


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Before/After: DIY This Moulding-Inspired Wall Trim For Under Five Dollars (And It's Not Washi Tape)
Architectural detail isn't exactly prevalent in most rentals, and while you would probably love to add crown moulding and paneling, your landlord may not be down with this. Also, these kind of projects can be something of an investment, and unless you have a long term lease, it may not be worth your while.
But what if you could do moulding-inspired trim that is somewhat more modern, fun and costs less than five bucks, but looks like a million? You totally can, and all you need is a spool of ribbon and some liquid starch.
Why use ribbon as opposed to washi tape? There's more texture and dimension in ribbon (we used grosgrain), as well as the ability to position it before sticking it to the wall, which is very helpful if you're doing this project solo. Also – it's much cheaper to use ribbon. We get ours at BBCrafts.com and it's around two dollars for 50 yards. Oh and in case you're wondering, this is fully removable without any damage to your wall.
Here's what you'll need:
Length desired of 3/8″ grosgrain ribbon
1 cup of liquid starch
1 small, clean paintbrush
1 scissors
1 pencil for marking wall
1 measuring tape
1 pack of push pins
Go 'head gurl and click through the slideshow for the step-by-step.