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AutomotiveTouchup paint products are custom mixed to perfectly match the color of your
2000 Toyota MR2 using a
basecoat/clearcoat system just like factory specs. To insure a
proper match, you'll need to know your vehicle's color code so you can find it on the
chart below.
The color code can be located in the driver side door jamb. The code will have a C/TR in front of it. A typical code will look like C/TR: 1D4/FH13, and 1D4 would be the color code in this example. Click here for Toyota paint code location diagrams and label examples.
Call 1-888-710-5192.
We probably have it.
Your 2000 Toyota MR2
is painted at the factory with a high quality basecoat/clearcoat system.
This two-step paint system consists of step one, the basecoat, which is
your car's actual color, and step two, the clearcoat, the specially formulated
clear paint that protects the base color and provides the luster and deep
shine your vehicle came with when new. AutomotiveTouchup products
faithfully reproduce your vehicle manufacturer's basecoat/clearcoat system.
I am really impressed with the touch-up paint. It matched perfectly and was easy to apply. I will recommend this product to anyone who is in need of such a thing.
Product was a perfect match and was delivered in a timely manner.
Excellent product, excellent service. I was able to repair the front bumper cover and several small areas of damage with outstanding results using the Aerosol cans. The color has been consistent over multiple orders and is indistinguishable from the original. All orders were received promptly. An easy and affordable alternative to expensive professional repair.
Share your touch up story...
Enter your year, make, and model below to find color matched paint:


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What's the Purpose of Life?
There remains as our main purpose in life the great issue of making something out of ourselves, of making progress in life. It's not enough for a man to be a shomer (observing) Shabbos and a shomer kol hamitzvos (keeping all the mitzvos)... It's not enough to avoid all the sins. You must accomplish something positive in life. — Adam's Ordeal (#28)
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subset: commoncrawl


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Risk Identification, Monitoring, and Analysis: In the Risk Identification, Monitoring, and Analysis session, you will learn how to identify, measure, and control losses associated with adverse events. You will review, analyze, select, and evaluate safeguards for mitigating risk.You will learn processes for collecting information, providing methods of identifying security events, assigning priority levels, taking the appropriate actions, and reporting the findings to the correct individuals. After collection of the details from monitoring, we can analyze to determine if the system is being operated in accordance with accepted industry practices, and in compliance with organization policies and procedures.
Identifying, Monitoring, and Analyzing Risk and Incident Response and Recovery(ISC)²
Acerca de este Curso
¿Podría tu empresa beneficiarse de la capacitación de los empleados en las habilidades más demandadas?Prueba Coursera para negocios
¿Podría tu empresa beneficiarse de la capacitación de los empleados en las habilidades más demandadas?Prueba Coursera para negocios
ofrecido por
(ISC)² is an international nonprofit membership association focused on inspiring a safe and secure cyber world. Best known for the acclaimed Certified Information Systems Security Professional (CISSP®) certification, (ISC)2 offers a portfolio of credentials that are part of a holistic, programmatic approach to security. www.isc2.org
Programa - Qué aprenderás en este curso
Understand the Risk Management Process
Module Topic: Risk Visibility and Reporting, Risk management Concepts, Risk Assessment, Risk Treatment, Audit Findings. In Risk visibility and Reporting, you will learn about risk register, creating a risk register, risk register, and risk management steps. In Risk Management Concepts, you will learn about, key terms, and generic risk model with key factors - NIST SP 800-30 R1. In risk Assessment, you will learn about NIST SP 800- 30 R1 risk assessment methodology, Step 1. prepare for the assessment, Step 2. conduct the assessment, Step 2a. identify threat sources, step 2b. identify potential threat events, step 2c. identify vulnerabilities and predisposing conditions, step 2d. determine likelihood, step 2e. determine impact, step 2f. risk determination, risk level matrix, risk levels, step 3. communicating and sharing risk assessment information, step 4. maintaining the risk assessment, and risk assessment activity. In Risk Treatment, you will learn about, risk mitigation, example control: passwords, control selection, residual risk, risk transference, risk avoidance, and risk acceptance. In audit Findings, you will learn about auditors, types of audits, audit methodologies, auditor responsibilities, audit scope, documentation, and response to audit.
Perform Security Assessment Activities
Module Topics: Participate in Security and Test Results, Penetration Testing. In Participate in Security and Test Results, you will learn about vulnerability scanning and analysis, vulnerability testing software categories, vulnerability testing qualities, potential problems, host scanning, host security considerations, traffic types, security gateway types, wireless networking testing, potential security issues, searching for rogue access points, locking down the enterprise, wireless tools, war dialing, and war driving. In Penetration Testing you will learn about penetration testing modes, white box / hat, gray box / hat, black box / hat, phase 1: preparation, reporting, phase 2: reconnaissance and network mapping techniques, reconnaissance, social engineering and low-tech reconnaissance, whois attacks, DNS zone transfers, network mapping, network mapping techniques, firewalking, basic built-in tools, phase 3: information evaluation and risk analysis, phase 4: active penetration, phase 5: analysis and reporting, penetration testing high-level steps.
Operate and Maintain Monitoring Systems & Analyze and Report Monitoring Results
Module Topics: Events of Interest, Logging, source Systems, Security Analytics, metrics, and Trends, Visualization, Event Data Analysis, Communication of Findings. In Events of Interest you will learn about, monitoring terminology, Intrusion Detection System (IDS)/Intrusion Prevention System (IPS), comparing IDS and IPS, types of IDS/IPS devices, deploying HIDS and NIDS, implementation issues for monitoring, monitoring control, other considerations, sample questions to consider, collecting data for incident response, monitoring response techniques, attackers, attacker motivations, intrusions, events, types of monitoring, and file integrity checkers, continuous/compliance monitoring. In Logging, you will learn about reviewing host logs, reviewing incident logs, log anomalies, log management, clipping levels, filtering, log consolidation, log retention, centralized logging (syslog and log aggregation), syslog, distributed log collectors, hosted logging services, configuring event sources (s-flow, NetFlow, sniffer), Cosco NetFlow, What is an IP Flow, IP packet attributes, understanding network behavior, how to access the data produced by NetFlow, How does the router or switch determine which flows to export to the NetFlow collector server, format of the export data, sFlow, event correlation systems (security, information, and event management (SIEM)), SIEM functions, compliance, enhanced network security and improved IT/security operations, and full packet capture. In Source System, you will learn about comprehensive application, middleware, OS, and infrastructure monitoring, hyper capabilities, and operations manager. Analyze and Report Monitoring: In Security Analytics, Metrics, and Trends, you will learn about security baseline, network security baseline, metrics and analysis (MA), systems security engineering capability maturity model (SSE-CMM), and potential metrics. In visualization topic, you will learn about data visualization tools. In Event Data Analysis, you will learn about logs, log management, log management recommendations, and Potential uses of server log data. In Communication of Findings, you will learn about checklist for report writers and reviewers.
Incident Response and Recovery
Module Topics: Preparation, Detection and Analysis, Containment, Eradication, and Recovery, Post-Incident Activity, Implementation of Countermeasures. In Introduction, you will learn about incident response, and basic definitions. In preparation, you will learn about elements of an incident response policy, incident response plan, training, incident response tools, communication planning, communication with law enforcement, media, requirements for effective incident handling, the incident response team, core team areas, centralized and decentralized teams, team structure, team conditions that support success, and other considerations. In Detection and Analysis, you will learn about Intrusion Detection Systems (IDS) and Intrusion Prevention Systems (IPS), types of intrusion systems, intrusion detection techniques, false positives and false negatives, anti-malware systems, security information event management (SIEM), Incident analysis, packet sniffers, Inline SSL decryption devices, incident documentation, records, assessing risk, response, containment strategy considerations, Delaying containment, areas of focus, defining an incident, triage, and notification. In Containment, Eradication, and Recovery, you will learn about common containment activities, and eradication. In post-incident activity, you will learn about effective incident response. In implementation of Countermeasures, you will learn about implementation steps.
- 5 stars84,69 %
- 4 stars14,20 %
- 1 star1,09 %
Principales reseñas sobre IDENTIFYING, MONITORING, AND ANALYZING RISK AND INCIDENT RESPONSE AND RECOVERY
The instructor is one of the best here. He knows how to teach, and provided well documented notes which makes it easier to go through. Thanks to ISC and coursera for this course.
Its the best and its training methodology is superb.
Good , i clear all my doubt about security and handling incidents
Very informative course and the tutor is really good !!!
Preguntas Frecuentes
¿Puedo acceder a una vista preliminar del curso antes de inscribirme?
¿Qué recibiré cuando me inscriba?
¿Cuándo recibiré mi Certificado de curso?
¿Por qué no puedo participar como oyente en este curso?
How long does it take to complete the course?
¿Tienes más preguntas? Visita el Centro de Ayuda al Alumno.


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PLEASE NOTE: We are currently not accepting new samples or orders until further notice. Thank you for your understanding.
The wool tumbling out of this bag is 100% pure Chow Chow, simply brushed and collected.
When spun and knitted, dog hair makes lovely things like these:
We can do it, you can do it, or we can do it together! Learn about how to collect your dog's hair, what kind of yarn it makes, what we can make with it, and get answers to all your questions on this site. You can contact us, too: just click on that green tab on the side of the page!


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No. I don't mean the E=Mc2. You can ask my wife. She says I have nothing in common with Einstein.
But in bass fishing, the long progression of advancements in knowledge, method, equipment and marketing of the sport seems to have passed by yet another generation of bass anglers. And while I don't think you can necessarily teach appreciation for what has brought us to this point, perhaps a little awareness of the past wouldn't hurt.
One case in point would be the career of John Powell of Montgomery, Alabama who died on Oct. 7 at the age of 78. Powell was a Korean War and Vietnam Air Force vet, but he was also one of the earliest figures in tournament bass fishing.
When I got my first B.A.S.S. patch around 1969, John Powell was as big as Bill Dance and actually preceded Roland Martin in elite status among the tournament pros as a contemporary of Tom Mann and Forrest Wood. He won three BASS events in his career, qualifying for the Classic 6 times. But more than that, in that era his numbers were exceptional, earning 16 top 10 finishes, 32 top 20's and 46 top 50's in all.
Furthermore, there was no gradual working his way up through the pro ranks. Powell won the first ever tournament held on Lake Eufaula, Alabama with 132 pounds—for three days! And no, he didn't walk away with the title; he had only a 2-pound advantage over the runner-up.
Today's fisherman might find it remarkable that Powell won without a single graphite rod, probably no rod over 5 ½ feet in length, nor fluorocarbon line, nor 100-horse outboard, or even a $100 Japanese rip bait. But he wasn't without some of the specialized amenities of the era. He competed with a 12-volt trolling motor, mushroom anchors and a flasher sonar.
Powell had the highest respect of his angling peers and a national audience that read of his exploits in Bassmaster Magazine. Yet none of his titles ever earned him more than $3000, and throughout his entire career he compiled less than $35,000 in cash winnings.
It's no wonder that Don Butler, winner of the second Bassmasters Classic in 1972, was fond of saying, "No one ever won a dime in professional fishing." Because for a long, long time, that was the case.
Powell, of course, like Butler, was a friend of Ray Scott, the B.A.S.S. founde,r and during the 1970's Powell joined Scott and Martin, on a national seminar tour that reached all the way to California. Powell was known as a shallow water fisherman, and the joke of the era was, he could be found fishing a "tire rut" after a rain shower.
Still, (and my memory isn't what it used to be) my favorite Powell account followed a 1971 win, I believe at Toledo Bend, but maybe Table Rock. Winds were a problem during the contest, and his standard method of Texas-rigging a 6-inch, purple with a yellow tail Crème Scoundrel, was not letting him get his bait down to the fish.
While your tackle box today probably holds half a dozen solutions to this problem, the innovative things you know about had yet to be devised or were yet to be exposed across the country. Powell only had what he had, so he improvised. To beat the wind, he ended up sliding four bullet sinkers on the line to get the bait down—and it worked.
No, I'm not lobbying that we go back to fiberglass rods with pistol grip handles. We're past that. But it's not what you have to use that sets you apart. It's what you do with what you have.
That's why I still remember John Powell.


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Trickbox TV provided ITV with its outside broadcast fly-away for the broadcaster's interview with US President Donald Trump.
Trickbox flew a crew member and the OB kit to Davos, Switzerland, where it was employed by ITV to record the exclusive one-on-one, Trump's first interview with an international broadcaster since taking office last year.
The company's OB solution provided ITV with a portable production unit (PPU), which is designed to enable broadcast quality, multi-camera projects.
"The interview has already been shown around the world on television and across social media and we're delighted to have been part of this high-profile project," said Liam Laminman, managing director, Trickbox TV.


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Save the INF Treaty, Save the World
President Trump wants to pull the U.S. out of an arms-control agreement that has been crucial to American and global security.
Secretary of State Mike Pompeo announced Tuesday that the United States will soon "suspend" its obligations under 1987 Intermediate-Range Nuclear Forces (INF) Treaty—an arms-control treaty credited with helping to end the Cold War – in response to the prolonged Russian violation of the agreement. If Russia does not return to compliance in 60 days, Pompeo said, the United States will formally announce its intention to withdraw from the treaty, as President Trump declared he would do last month.
The two of us have advised President Trump in different capacities—Burt as an informal campaign adviser, and Countryman as a top State Department official in the early days of his administration. Together, we have decades of experience at the highest levels of U.S. foreign policy dealing directly with the toughest weapons-related security challenges.
While we agree the Russian violation is serious and must be addressed, terminating the agreement does nothing to convince the Kremlin to return to compliance or reverse any military advantage that its noncompliant missile might provide. Nor is it realistic, as Secretary Pompeo "hopes," that the threat of U.S. withdrawal will convince Russia to "change course" and return to compliance with the treaty.
Why does the INF Treaty matter? The agreement effectively eliminated some 2,700 U.S. and Russian nuclear-armed missiles and prohibits an entire class of destabilizing nuclear systems that had targeted NATO and Western Russia.
Critics of the treaty, including national security adviser John Bolton, say it has outlived its usefulness and should be terminated if Russia does not return to compliance. The reality is that it continues to serve as a check on some of the most destabilizing types of nuclear weapons that the U.S. and Russia could deploy, and without the treaty, there is a serious risk of a new intermediate-range, ground-based missile arms race in Europe and beyond.
If U.S. and Russian and NATO leaders are serious about preserving the INF Treaty—and they should be—they must redouble their off-and-on diplomatic efforts to find a practical solution that resolves U.S. concerns about Russian compliance and Russia's concerns about U.S. implementation of the treaty. Such an effort requires stronger European leadership and initiative, as it is very unlikely that either the White House or the Kremlin are in a mood to put forward realistic solutions.
In 2013, the United States determined Russia had tested a missile in a configuration that violates the treaty. After five years, the key details of the nature of the violation were publicly revealed for the first time in a Nov. 30 statement from Director of National Intelligence Dan Coats. "As of late 2018," Coats said, Russia "has fielded multiple battalions of 9M729 missiles, which pose a direct conventional and nuclear threat against most of Europe and parts of Asia."
For several years, our organizations have called upon Moscow to return to compliance with the INF Treaty. We've engaged with experts and officials in both the D.C. and Moscow to present real solutions that would appeal to both parties, including the potential for reciprocal inspection visits that could lead to the removal of Russia's noncompliant missile, and to address Russian concerns that U.S. missile defense launchers in Europe could be used to launch offensive missiles. So far, U.S. or Russian leaders haven't listened.
In a meeting in June with Russian officials, we understand that Trump administration officials apparently demanded that Russia admit its violation, exhibit the missile, and withdraw it from the field. Unfortunately, there have been no working level follow-on discussions on the option and no offer for reciprocal measures to address Russia's concerns.
According to reports, there was no Cabinet-level interagency debate before Trump announced his INF decision last month, which would normally happen before a national security adviser would recommend withdrawal from an agreement to the president. Neither was there any serious consultation with Congress before Trump's announcement.
And while our allies in Europe—those directly threatened by the Russian violation—had discussed the issue with Defense Secretary Jim Mattis in early October, they were not formally consulted before the president announced his intention to terminate the INF Treaty on Oct. 20. Unsurprisingly, NATO allies have, with near unanimity, reiterated their view that INF is key to European security. Many have called for renewed U.S.-Russian diplomacy on the matter.
On Nov. 26 press briefing, Russia's Deputy Foreign Minister Sergey Ryabkov reiterated Russian denials of the U.S. charges of noncompliance but said Russia is "open to any mutually beneficial proposals that take into account the interests and concerns of both parties." It is in our interest to test whether Russia is serious about such an effort.
If President Trump does end up killing the INF Treaty without exhausting the options to bring Russia back into compliance, his Kremlin counterpart Vladimir Putin will have been granted the double victory of keeping his new ground-launched cruise missile, while being able to portray the United States as responsible for the termination of a valuable agreement and for opening the door to renewed deployment of intermediate-range missiles.
Another threat to American security—and global security—can be found in President Trump's threat to enter a global nuclear arms race and a return to a 1960s-era nuclear posture that sought American military superiority—measured in megatons—and his failure to engage in talks designed to preserve another key treaty designed to reduce the threat of global nuclear destruction: the 2010 New Strategic Arms Reduction Treaty (New START).
New START is the latest in a series of agreements pursued by U.S. presidents of both political parties and Russian leaders that have lowered tensions, reduced the incentives for first nuclear use and spared defense budget dollars for other priorities. Its powerful inspection and verification measures provide a valuable window into Moscow's capabilities, one that can't be matched by the rest of American intelligence resources.
As we and other colleagues recently warned in a Nov. 7 letter to the president, if New START is allowed to expire in February 2021, there will be no numerical limits on the still massive U.S. and Russian strategic nuclear arsenals for the first time since 1972.
It doesn't have to happen this way. Both the Congress and NATO allies must assert a voice in decisions that are life-and-death for the United States, Europe and the world. They can exert stronger pressure on Moscow to end its INF violation and reject the militarily useless path of developing, building and deploying new U.S. missiles in Europe or elsewhere. The next Congress should be also prepared to tie continued funding requests by the Trump administration to build up and modernize our nuclear arsenal (projected to cost $1.7 trillion over the next 30 years) to a decision to extend the New START agreement.
Most immediately, Trump and Putin should direct their teams to follow through on what they discussed briefly in Helsinki: the beginning of a bilateral dialogue on strategic stability, with the aim of avoiding a new arms race, pursuing a final effort to resolve the INF Treaty dispute, and beginning talks on extending New START.
With all that currently divides the United States and Russia, these two leaders have the opportunity to take a step that would reassure the world that they each understand the terrible responsibility they bear as custodians of civilization-ending weapons.


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Wreaths are the perfect way to transition your home decor from one holiday to the next. This pink polka dot leaf wreath is fitting for Valentine's Day but will carry you all the way into spring! Have you ever seen a polka dot plant? Also known as a Freckle plant, it comes in beautiful shades of pink and green, and the leaves showcase sweet spots and splotches. So let's brighten up that front door and get started!
Supplies Needed:
- Silhouette CAMEO® or Silhouette Portrait®
- Silhouette Studio®
- Silhouette Cutting Mat
- Silhouette Cutting Blade
- Scraper Tool
- 5 sheets Double-sided Adhesive
- 8 pieces 8.5-by-11-inch Light Pink Cardstock
- 2 pieces 8.5-by-11-inch Dark Pink Cardstock
- 24-gauge spool wire
- 18-gauge floral wire stems
- Green Floral Tape
- Green and Pink Markers
- Design ID #21378
Step One: Prepare Your Paper and Wire
We're going to use the double-sided adhesive and pink cardstock to create paper leaves that look lovely from both sides!
1. Take a piece of double-sided adhesive and remove the white liner.
2. Take a piece of light pink cardstock and carefully align the paper with the sticky side of the adhesive. Smooth out any bubbles with the scrapper tool.
3. Repeat this process with the four other sheets of double-sided adhesive and light pink cardstock. Set these aside.
4. Cut 24-gauge spool wire into 3-inch pieces with strong scissors or wire cutters. You'll need about 100 pieces total.
Step Two: Format the Leaf Template
1. Open Silhouette Studio® and insert the Leaf Trio design (Design ID #21378).
2. Open the Page Setup panel and change the page dimensions to Letter (8.5 by 11.0 inches).
3. Ungroup the image by right-clicking and selecting Ungroup from the drop-down menu.
4. Delete the two leaves with the stems.
5. Select the remaining leaf, right-click, and select Ungroup. This will allow you to delete the inner leaf, leaving you with a single outline of a leaf. This is what we want!
6. Size the leaf so it's approximately 2.5 inches tall from top to bottom. It's helpful to reorient to leaf to be straight up and down. (To do this, select the leaf and move your mouse so that it is over the green circle that is over the design. Click and drag the green circle until the leaf is positioned how you desire.)
7. Select the leaf and open the Replicate panel located on the right-hand toolbar. Select the Fill Page option.
8. Now you're ready to cut! Select the SEND tab on the upper right side. Change the material to "Double-sided Adhesive." Adjust your blade as necessary unless using the AutoBlade.
9. Align one piece of the double-sided adhesive/pink cardstock onto the cutting mat, with the yellow liner side down and pink side up, and then load the mat into the machine. Click Send to cut out the leaves.
10. Repeat for two more adhesive backed pieces of paper.
11. Change the material to "Cardstock, Textured- Heavy – (80 lb)" and cut 3 pieces of plain cardstock (without the adhesive backing)—2 light pink and 1 dark pink.
Step Three: Decrease the Leaf Size
1. Return to Silhouette Studio® and select all of your leaves and move them off the cutting mat into the gray space.
2. Duplicate one leaf and drag in onto the cutting mat. Decrease the size of this leaf to 2 inches tall.
3. Select the leaf and click on the Replicate panel. Select the Fill Page option.
4. Select the Send tab and cut out the 2 remaining adhesive-backed pink pages and the 3 remaining pieces of plain cardstock. Make sure to change the material type in Silhouette Studio® as necessary.
Step Four: Creating your Leaves
1. Now that you have all your leaves cut, remove the yellow liners from the adhesive-backed leaves.
2. Place a cut wire with about about one inch onto a leaf and the remaining wire sticking out of the bottom.
3. Then place a plain paper leaf over the wire and smooth out the paper with the scraper tool. This sandwiches the wire between two pieces of paper, giving the leaf a clean appearance from both sides.
4. Repeat with all the leaves.
5. Add small dots with your green marker to one side of each leaf. Then add a few splotches with your dark pink marker to just a handful of the leaves.
Step Five: Creating your Wreath
1. Cut your 18-gauge wire stems into 8-to-12-inch-long pieces.
2. Take one wire piece and one leaf and wrap together with floral tape. Add another leaf an inch below the first and continue wrapping with the tape. Add leaves until you have a total of about 8 to 12 leaves on one stem. This creates a bough.
3. Repeat the step above to create more boughs until you've used all your leaves.
4. Then connect the boughs by overlapping the ends slightly and wrapping with floral tape.
5. Form the boughs into a circle by gently bending the wire stems. Fluff out the leaves and manipulate the wire gently with your hands.
Ta da! Hang your wreath on a wreath hanger, and you're sure to come home happier!


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Viejas Casino
Viejas Casino
Alpine, CA 91901
Viejas Casino Information+ -
Top 5 Things To Know About Viejas Casino:
- Location: Viejas Casino in San Diego is located in Alpine, California, which is a little over thirty minutes away from the coastal area.
- Game Tables: Place your bets and see if Lady Luck is on your side as the San Diego Viejas Casino features numerous table games including classics like Texas Hold 'Em, Blackjack and Poker.
- Slots: Pull the lever of the one-armed bandit and see if luck is on your side at San Diego's Viejas Casino. The casino presents more than 1,800 slot machines to offer you entertainment and big wins.
- Dining: San Diego Viejas Casino provides various restaurants, bars and lounges where you can celebrate your wins or nurse your ego back to health after a few unlucky hands. The casino includes a steakhouse, buffet, cafe, coffee bar and several other restaurants including a Mexican and Asian eatery.
- V Club: If you're a regular visitor to San Diego's Viejas Casino, you should consider joining the V Club, which grants you points every time you use your V card. Depending on the number of V Club points you rack up, you can receive discounts, gift cards, cash back and tons of other exciting benefits.
If you're feeling lucky, you should head over to San Diego Viejas Casino to test your luck. Try to match up the fruit at the slot machines or try out your poker face at the Texas Hold 'Em table. If you're a poker pro, San Diego's Viejas Casino features a poker room where you can cross your fingers for luck and challenge others in Omaha and Stud tournaments. The San Diego casino also includes an off-track betting area with twelve television monitors and 45 personal monitors for you to follow the horse races and root for the next-generation Sea Biscuit.
Whether you want to buy a round of drinks to cheers to your success in the game rooms or perhaps your need a lucky pick me up before you return back to the slots, head over to V Lounge at San Diego Viejas Casino for a cocktail at the circular bar. And if all that hoping and praying at the table games has you worn out, take a break at Grove Steakhouse and treat yourself to filet mignon paired with a glass of wine. The casino also features Far East Express, which serves Asian cuisine, and North of the Border that fills up guests with carne asada burritos and fish tacos. If you're in search of some quick grub between games of bingo, check out the 24-hour cafe or The Coffee Bar.
- Do Check Out the Entertainment: The Casino features live entertainment at the V Lounge and the on-site Dreamcatcher music venue. The venues feature DJs and musicians that perform everything from top 40 hits to oldies favorites.
- Don't Forget Your Appetite: Check out the casino's buffet, which serves copious amounts of food from the all-you-can-eat crab legs, fajitas, pizza, pasta and carving stations. Make this your first stop so you'll be full and focused when you hit the game room.


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Peeping Tom
When Peeping Tom was released in 1960, it was greeted with widespread critical condemnation. Reactions were so hostile that the distributor pulled the movie from release after only a week. Derek Hill of the Tribune said, "The only really satisfactory way to dispose of Peeping Tom would be to shovel it up and flush it down the nearest sewer. Even then the stench would remain."
Go to the review


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Facebook made a recent overture to purchase Twitter for a reported $500 million, according to Kara Swisher in her BoomTown blog. The offer was a stock transaction and beyond the usual question of price was the concern about whether the shares being offered were actually worth that much.
Swisher explains: "The Twitter side felt that figure was inflated and the shares should
be valued at the lower figures that have also been reported for
Facebook's true valuation, more in the $5 billion range. That would have given the deal a $150 million price tag, which was
seen as too low, especially since it was in Facebook stock and not cash." This theme has dominated much of the online discussion today.
Chris Brogan, a prominent social media evangelist with more than 21,000 followers on Twitter, said the deal might be successful if Facebook were simply looking for an investment. But in the more likely case where a merger would occur, he was very bearish on the outcome.
"Twitter is an already hot ecosystem. It doesn't need integration with the new Borg to make it better. In fact, that would likely kill it," Brogan told Media Bullseye. "This isn't the same as AIM buying MSN Messenger or similar. It's not even ICQ sucked into AIM. It's like your telephone being sucked into the home entertainment center. It's that different, the mode in which we use it," he explained.
Laura Fitton of Pistachio Consulting agreed that integrating Facebook and Twitter would not be a good idea. She also said that the "pie in the sky" valuation of Facebook stock does not make sense in the current economic climate.
But it is the corporate culture of Facebook that concerns Fitton most. In an interview with Media Bullseye, she said that Facebook's attempts at monetization thus far have been "ham-handed" and they haven't proven they can live up to the "do no evil" mantra popularized by Google and carried out, in her view, by Twitter. She described Facebook's Beacon project as one that could have been very powerful if handled properly, but she felt that the popular startup did not execute it well.
Others suggested selling Twitter wasn't a bad idea, just not to Facebook. "Goodness sakes, Google. Buy Twitter already. It's exactly what you need, & if you don't, something silly will happen, like Facebook," opined David Nielsen.
Entrepreneur Kevin O'Keefe made a different suggestion after noting he was pleased the talks are off. "I like well funded Twitter with LinkedIn running a Twitter API," he posted.
Brogan may have summed up the overall community reaction, however, when he told me, "I hope smarter product management minds prevail."


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Core Administration
Industry changes are creating an imperative for health plans to transform the way they do business. What was once status quo has now become a dynamic, fast-moving landscape.
The shift to new business models, including those leveraging value-based payments and benefits, ACOs, public and private exchanges and growth in the Medicare and Medicaid segments all represent opportunities for health plans embracing change. In addition, the need to stay compliant in the face of evolving regulatory pressures and growing expectations by consumers of a customer experience similar to that provided by other industries present immediate and unique requirements to stay competitive.
All this while striving to contain and lower both administrative and healthcare costs.
According to Gartner, "The imperative to change demands a complete re-evaluation of payer industry business priorities, customers and competitors. Payer leaders — including not only CIOs, but also CEOs, CFOs and boards of directors — must adapt to new industry-wide forces right now."* The ability to harness all available information, initiate proactive health actions and communications, provide an optimized customer experience and connect everyone involved in the healthcare delivery cycle in real-time, while at the same time controlling costs, is now critical for success.
For many health plans, outdated technology is causing expensive workarounds and manual processes that prevent a successful response to new business opportunities. The unavoidable reality is the need for a next-generation core administrative platform that can not only keep up, but also provide a unified solution for the future.
A big milestone for AmeriHealth was when we brought a very large customer – a health plan managing 300,000 lives – up in a very short period. This clearly demonstrated HealthRules' agility and speed."
John Janney, Senior Vice President, Transformation
AmeriHealth Administrators
In a recent Voice of the Market Survey commissioned by HealthEdge and conducted by Survata, health plan executives identified member satisfaction as the top-ranked organizational goal for 2018. Those same executives selected "Modernize technology to enable resiliency to change" as the top priority to achieve their organizational goals.
The most transformative health plans are using the award-winning HealthRules product suite from HealthEdge to drive new levels of agility, efficiency and transparency across their organizations, while simultaneously delivering superior customer experiences. Health plans implementing HealthRules have benefited from unparalleled flexibility, enabling them to quickly address market opportunities and stay in front of their competition. They have also achieved new levels of transparency and customer service as they are now able to provide accurate, real-time information to everyone involved in the care continuum. And those same health plans have achieved this while simultaneously automating their critical manual business processes, resulting in significantly lower administrative costs and an enhanced bottom line.
Join the growing ranks of leading health plans transforming their place in the dynamic healthcare marketplace.
*Business Drivers of Technology Decisions for Healthcare Payers 2018, Gartner


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|iZotope makes innovative products that inspire and enable people to be creative. iZotope has spent over a decade developing award-winning products and audio technologies for professionals and hobbyists alike.
|MVP Loops MVP Virtual, MVP Platinum, VIP Loops Platinum Series, and Dig Audio represent the in-house brands of MVP Loops. All of these brands are produced, developed and created by professional producers, sound engineers, and recording artists. MVP Loops promises quality customer service, great pricing, and the most modern sounds and samples.
|Studio Devil tube amplifier modeling plug-ins and software utilize sophisticated algorithms from Gallo Engineering to bring you the best in simulated vacuum tube amplifier tone.
|QuikQuak specializes in quality music and effects plug-ins for Windows and Mac. – VST and AU formats.
|BeatRig is an Amsterdam based company that provides tools for music production. "We believe that making music is about 'ideas' instead of 'technology'. Giving your ideas freedom to flow with our easy to use tools."
|Shok has created thousands of loops and sounds for Mixcraft since 2011. He is a Los Angeles-based producer, composer and multi-instrumentalist, and is half of the Electro Swing band Red Light District.
|Applied Acoustics Systems was founded in 1998 and is based in Montreal, Canada. A privately-held company specializing in innovative audio products for Mac and PC computers providing software-synthesizer programs for amateur and professional musicians.
focus is creating high-quality progressive music instruments and effects, designed to break through barriers and help you push your musical
|Adgproductions.com produces high-quality music instruction books for pianists and keyboardists.
SFXsource.com sound library provides a huge selection of pro
sound effects and royalty-free music to download for media productions.
|Freesfx.co.uk is home to a vast collection of free sound effects and samples for use with Mixcraft.
|Peaceloveproductions.com provides a destination to download royalty free music loops, beats, and samples for use in any music software.
Jason Donnelly (Dj Puzzle) is a Dj/Producer from Chicago who has produced over 30,000 loops for labels Loopmasters, Sony Creative, Peace Love Productions, Acoustica, Sound Trends and more.
|nobleapplications.com - Noble Applications develops high quality, reliable, and maintainable mobile apps, specializing in audio apps and solving difficult problems.


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Mental health issues can leave people feeling isolated and ashamed. To counter misconceptions
about mental illness and help connect people with resources, the Texas Department of State Health Services is today launching Speak Your Mind Texas, a statewide conversation about mental health that will spread the message that help is available and recovery is possible.
DSHS is working with local organizers to conduct town hall-style community conversations around
Texas this summer to spark discussion about mental health and substance abuse, beginning this morning in Fort Worth.
Speak Your Mind Texas is designed to break down the stigma often associated with mental illness
and emotional disturbance and remove barriers to support and treatment,
particularly among teens and young adults. DSHS encourages anyone involved with
young people, including parents, teachers, coaches, community and church
leaders, and others, to participate in a Speak Your Mind Texas community
conversation in their area. Participants will learn about mental health issues
affecting their community, the warning signs of mental illness and substance
abuse, and the resources available to help young people and those who support
them face these challenges.
"People don't like
to talk about mental illness, and they don't like to hear words like
schizophrenic or bipolar, and we first have to get over that," said Derek
Dillard, a young adult who experienced bullying and depression and attempted
suicide before successfully seeking treatment with the support of his family.
He is one of four young people who candidly lend their voices and stories to a
series of videos and public service announcements for Speak Your Mind Texas.
"Once we start
talking," Dillard said, "we can start making changes."
Resources at
speakyourmindtexas.org will help people recognize mental illness and substance
abuse and show them how to provide support, promote hope and foster recovery
for people experiencing mental illness or emotional disturbance. Resources are
also available by dialing 2-1-1. DSHS is supporting Speak Your Mind Texas with
a media campaign that includes television and radio public service
announcements, online ads, and digital and social media outreach.
"An estimated one in five Americans will
experience a mental health issue during their lifetime, and one in 20 will
develop a serious mental illness," said Dr. David Lakey, DSHS commissioner.
"Mental illness often strikes early, with half of all lifetime cases beginning
by age 14 and three-fourths by age 24. That's why Speak Your Mind Texas is
focusing on our state's youth and the people and organizations that support
"People can and do
recover from mental illness and substance abuse issues," Dr. Lakey said.
The campaign is
part of an overall Texas effort to raise awareness of mental health issues and
increase access to services. The Texas Legislature added more than $300 million in additional mental health funding
for 2014-2015. The funds are being used to expand services, decrease wait
lists, make improvements at the state's mental health hospitals, and develop
targeted efforts for veterans and young people.
(News Media Contact: Chris
Van Deusen, DSHS Press Officer, 512-776-7753)
DSHS Press Office on Twitter
Visit speakyourmindtexas.org for
additional details as they become available
June 9 – Fort Worth8:30 – 11 a.m.The Women's Center1723 Hemphill St.
July 1 – Houston
July 8 – Kerrville
July 14 – McAllen/Edinburg
July 16 – Brownsville
July 21 – Midland/Odessa
July 23 – Abilene
July 24 – Lubbock
July 25 – Amarillo
July 28 – Tyler
July 29 – Lufkin
July 30 – Dallas
Aug. 12 – Waco/Temple
Aug. 13 – San Antonio
Texas Homeland Security | Statewide Search | Texas.gov | Texas Veterans Portal | Privacy Practices | Report Fraud, Waste, and Abuse


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Namuang Safari Park
Attraction Na Muang Safari Park Ko Samui District Surat Thani Thái Lan Published on: 13-11-2015
|1 hours 30 mins
|First-time visit
Must see
Namuang Safari Park is good for
- Highly recommended by fellow travellers.
Image copyrights belong to authors
Why Namuang Safari Park is special ?
Namuang Safari Park, on the southern side of Koh Samui about 30 minutes from the airport and a few kilometers from Nathorn pier, has become a must-see tourist attraction. The 35-rai park has been an adventure destination since it started operation ten years ago with its now very popular elephant trek and crocodile show.
For the nature lovers and adventure seekers who can't get enough of Koh Samui's exciting adventure offerings, the Namuang Safari Park has added new attractions they shouldn't miss during a Koh Samui Holiday. Beside the popular elephant trekking and a trip to Namuang Waterfall 1, the tour now offers off road mountain tours on a 4x4 and cable rides not for the faint of heart.
Source: http://www.the-best-about-thailand.com/
What to explore at Namuang Safari Park?
Enjoy a fun family day out at Namuang Safari Park.
Watch the entertaining elephant show or if you prefer go elephant trekking in the jungle.
Choose from a variety of other shows on offer including : monkey show, crocodile show, bird show, snake and scorpion show.
Visit the highest waterfall on Koh Samui and have a cooling swim or take the cable ride high in the tree tops.
Go and feed the animals in the mini zoo or if you wish, be photographed with your favourite tiger or leopard cub.
See a demonstration of rubber tree tapping and afterwards eat a delicious lunch with fresh fruit.
Source: http://www.tropicaleasy.com/
How to get to Namuang Safari Park?
To find Namuang Safari Park take the 4169 ring road heading from Lamai to Nathon. After the temple of Wat Khunaram take the first turn on the right just after the Gasoline Station.
Selling points
- "Absolutely fun!"
- "Decent afternoon out"
- "Lovely day for whole family"
- "Great Waterfall Hike!"
- "Thrilling 4x4 Koh Samui Safari Tour"
Na Muang Safari Park Ko Samui District Surat Thani Thái Lan
Tips for you
Удивительное и прекрасное путешествие! Смело берите тур!!!
Hang on during the ride with crazy but cool drivers! Ride on top and have twice the fun. But bring a plastic raincoat & a towel. It might rain even if it starts out sunny!
Elephants were perfect.that was amazing show. Safari was perfect too:-)
Safari ve pilav
Picturesque waterfall
See a lot of mixed reviews here.. Maybe I should have posted my review before reading, and I would have changed it to lower? That being said I didn't see any mistreatment of animals. People don't always understand "training" sometimes it appears rough, but really does no harm to the giant animals. I saw nothing that looked out of place, elephants seemed happy to walk around and eat food. I really enjoyed touching and feeding the elephants, you can get up close and personal. I would do it again. The waterfall hike to the top can be pretty treacherous be ready for it, or don't. Didn't seem overpriced. seems like a good value to me, and the elephants seems pretty content. Can't comment on the "other" shows , as I didn't see any.. I also don't see any problem, in someone asking for a tip to take a bunch of pictures of you on your elephant. Don't be cheap a HUGE tip for them is $5.
Hang on during the ride with crazy but cool drivers! Ride on top and have twice the fun. But bring a plastic raincoat & a towel. It might rain even if it starts out sunny!


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Geography may have lost its luster among curriculum creators, but it remains an important consideration when planning a data center. After all, no business wants to locate such a critical component to its overall mission in a place where it will be under six feet of water in six months.
Threats to a data center from natural disasters can be reduced depending on where the facility is located. When it comes to natural disasters in the
Based on presidential disaster declarations over the last eight years, data centers as less likely to suffer service interruptions from natural disasters in the Northwest than in any other part of the country.
According to the agency, from 2000 to 2008, FEMA Region X, made up of
The Northwest offers other more economic benefits as well. As we have pointed out in past blogs, one of the prevailing concerns with data centers is their massive power consumption to both run the servers and cool the data center as a whole. And this is another reason to favor the Northwest.
As Vertatique points out in their blog,
"...the popularity of the
for mega data centers [is] due to its inexpensive and low-carbon hydroelectricity, its climate which reduces cooling costs, and its fiber optic infrastructure. " Columbia River Valley
A close second to the Northwest as a relatively safe place to locate a data center is directly on the other side of the country. During the period tracked by FEMA, Region I, comprised of the
However, electricity costs in the Northeast (
So considering the Northwest's cheap and abundant power, as well as the relatively small incidents of natural disasters, there is really no wonder why companies like Microsoft, Google, Yahoo, Ask.com, and Intuit Inc. have been flocking to the Northwest to build out mega datacenters.


text: The charming Serrano apartment designs in this apartment review series was show modern, futuristic, minimalist, and glowing of a residence. The whole space of this apartment was giving us more than an usual inspiring landscaping but also the conceptual imagination for our own apartment. If we were see this apartment correctly, we will see that the designer of this apartment use the white light application to show the charming character of this apartment. The combination of both black and white landscaping in this apartment series will give a simple theme for our residence. These exclusively minimal workspace layouts were use the maximal landscaping of the room and use the multifunctional furniture. We can see the integration of office desk with the wall system uses in this workspace. The minimal look of this workspace comes from the thought of simplicity and effectiveness. These modern kitchen designs pictures will inspire us with applicable thought and plaint application. Look separated but the main point of this space still can be seen here. The most super comfy in this apartment was completed with the canopy system, and now please enjoy these unique glossy bedroom ideas.[via]


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True leaders do what good people do every day and have no need for the title, in fact, some of the most effective leaders have no idea that they are serving people in the way that they do.
Far too many people like the idea of being a leader, they seem to think others will be impressed by the title and respect them more. Perhaps it's an idea that they will have an extra measure of power (whatever that may be).
Here are ways to recognise an ineffective leader:
Unable to stand for anything: Having an opinion and being outspoken about what you believe in provides much-needed security for people around you. They can follow and respect you if you are able to hold an opinion and not be changed by the opinions of others. This may not sound that important, but a true leader needs vision and should be able to completely focus on that vision. This brings the stability that people require.
Own needs more important than that of the group: Wanting the best for yourself should never come at the cost of others. This is often seen when targets need to be reached and there is only a reward for the leader and not the team. Being a good leader means helping everyone achieve according to the work they have delivered and not just gratification to the person shouting the loudest.
The idea of working hard: If you think you work hard, you need to find better and more efficient ways of working. Perhaps you need to slow down and assess what is really important. If you cannot find a way to work smarter how will your team ever be able to? Realise that you need to find ways of making yourself more productive before you expect others to be more productive. That is leadership and it takes work.
Lack of Empathy: Empathy is often considered as a soft and fluffy optional extra, when in fact it is the most important attribute needed. Empathy is understanding, not accepting excuses because unfortunately excuses do not get the job done, and they definitely don't pay the bills. A leader's empathy needs to be coupled with responsibility. When you hear excuses it is often better to remind the person that they are ultimately not working for you, but rather the family at home that are expecting them to bring enough money home to support them. It's the principle of tough love and as a leader, you will need to be tough.
Unable to communicate: We are social creatures and we need feedback, if you wish to have any measure of success as a person or a leader, you will need to learn to overcommunicate. Start with your family, recognise them and spend more time communicating and thinking about more things you can say. This will make it easier to communicate and recognise people in your team.
Leadership is about serving people, and the reason we serve people is to make them more effective so that they too can lead. The responsibility of a leader is to develop more leaders, so before you make a decision you have to ask yourself "Is what I am about to do going to make this person a better leader?" That is the only long term consideration that needs to be pondered.
These are some of the common failings of people who think they are leaders. In case you are unfortunate enough to be in the presence of such a person, I wish you all the strength and patience in the world. Try to learn and remind yourself daily to be different and perhaps you will be able to lead them from arrogance to a point where they can change.


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Hey! Thanks for dropping by.
So, I finally did it. While preparing for my Oct. 1st reading at Paragraphe Bookstore in downtown Montreal, my husband videotaped my practice run in our home (in fact, I'll embarrass him now and tell you all that he even set up a little candlelight café in our living room the night before, so he and our daughter could be the first to hear me read, in a café-like setting. Made my night).
I'd like to share my reading with those readers who weren't able to attend and asked to see it. So, here's Part I of what will be a four or five-part post (in 3 minute segments). I'll post Part II today (Three poems from Leap), and save the other parts for another day. Someone did videotape the actual reading at Paragraphe Bookstore, too. I'll share that on vimeo once I receive that clip.
There are some photos from the 'PWAC READS' event at my Facebook Author page, http://facebook.com/heathergracestewart
As always, thanks for reading, watching and commenting.


text: Anthony says: I loved Aliens. I've wanted to jump back into the boots of a Colonial Space Marine ever since I briefly played the original AvP game on my friend's PC, so I'm definitely interested in checking this one out as it gets closer to release. And if you're skeptical about the developer you should know that this is the same team who made the original PC version and the popular version for the Atari Jaguar.


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Pure, original, untouched: three words rarely used to describe grape growing regions around the world today. Many original rootstocks have been gradually destroyed in various parts of the globe, due to Phylloxera- a microscopic louse that feeds off grape roots. However, thanks to its geography and climate, Chile remains untouched: free to harvest clean, strong grapes to cultivate into the wine we cherish and adore. Vina Ventisquero Root 1 Sauvignon Blanc is a bold testament to that statement.
The 100% Sauvignon Blanc grapes that make up this delicious wine are grown in Ventisquero's vineyard located in Casablanca Valley- a region that remains mostly cold, and highly recognized for its quality Sauvignon Blanc and Pinot Noir. Not only does the cool climate assist the wine to preserve its fresh acidity, but help from the Pacific Ocean breeze, just a little over nine miles away from the vineyard, is a great addition to that freshness. Combine that with the bright afternoon sun, and we have ripening that is slow and steady, cultivating bright tropical flavors.
This crisp wine offers bright citrus notes and a fresh, pure finish. Vibrant flavors of grapefruit, lime, pineapple, and pear are present, combined with a hint of herb, creating a complex, elegant finish. Served best with grilled shrimp or pork loin. Grilled Vegetables are also a great match, and roasted lemon chicken.


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As the saying goes, "a picture paints a thousand words": but which words? Understanding our past determines actively, our ability to understand the present. So how do we write our own histories, personal and cultural, and therefore define ourselves ?
I cannot quite remember when my obsession with Victorian cemeteries began, though I never think of myself as a morbid person, and of course, my fascination was not anything to do with death, quite the contrary, it was to do with life: the lives of those that had gone before us.
The cemetery is a unique product of the Victorians, only they could have conserved it: a city for the dead. Their beliefs, values and fears are here, written in stone. Nothing reveals a society better then the manner in which it disposes of its dead . Monuments are not simply art works or grave markers that represent their patrons' existence, or that act as subconscious reflections of aesthetic and commemorative ideals. For, as the texts inscribed on many tombs propose, monuments designed to be deliberate messages from the past to posterity. Unlike most historical sources, which are read, analysed, dissected and contextualised by the inquisitive historian, a monument is the self-proclaimed voice of the past, an extended obituary from the past in to the present. It actively demands our attention and even competes with the visions set forth by other tombs .
Commemorating the dead
Commemoration may take many forms, and serve several purposes. For the wealthy several types of monuments are available, and can be seen as a demonstration of one's status in life, and a confirmation of one's place in death, so for the poor, there may be nothing. However saying this, history itself can venerate the death of the poor, for instance when there is an historic event arising out of their untimely demise. In cemeteries, stone crosses, grave slabs and grave markers are extremely common, and many of these are clearly designed to both to make the grave and to serve a commemorative role. For the rest of society forms of commemoration were undoubtedly just as important as for the wealthy, although they are less elaborate and expensive. The dead of the poorer sectors of society might also be remembered by burial in or in the vicinity of prominent locations or features of the landscape, or near to commemorative monuments .
A monument is a type of structure either explicitly created to commemorate a person or important event or which has become important to a social group as a part of their remembrance of past events.
The social meanings of monuments are rarely fixed and certain and are frequently 'contested' by different social groups. As an example, near to the town of Bewdley you will find this unusual, but not uncommon monument.
One history group said;
"It is a 'mortsafe'; a device to protect the newly laid to rest form the excesses of body snatchers".
Indeed The authorities turned a blind eye to the grave-rifling because surgeons and students were working to advance medical knowledge. They kept publicity to a minimum to prevent people from realising what was happening. In the early 19th century, with the great increase in numbers of schools and students, there was continual rifling of lonely graveyards, however this device was not robust and would not have prevented a grave robbery.
Another group said;
"This is a grave from the Victorian age when a fear of zombies and vampires was prevalent; she could even be a witch. This cage was intended to trap the undead just in case the corpse reanimated".
I thought that this had a more symbolic meaning so contacted Doctor Julian Litten who responded by saying;
"Thank you for your e-mail. As you suggest, the item appears to be insufficiently robust to be a mortsafe per se. It is, in fact, a wreath-rack, on which such items as immortelles (wreaths of either porcelain or dried flowers) would be placed throughout the year. There are a number (thought not many) of these items around; they were not 'standard stock' items and were invariably made to order by local blacksmiths. This appears to be such an item".
I promptly passed this information back to this group, who were not pleased; I had just destroyed their witch legend.
It is not only the victors who write history, occasionally, we write our own historys….
….leaving so many questions unanswered; who was this person, why did this persons loved ones choose to commemorate their passing in this way, what story is this gravestone telling?


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CF7 series introduces the advantages of a Flat Bed Oven into our Combination range of Microwave Ovens. The absence of a turntable significantly increases cooking flexibilities, and new Panasonic technology guarantees even and uniform cooking. A full temperature range of 100C-250C, ensures success when cooking anything from meringues and pastries to roast joints.
Combination cooking can reduce the cooking times by half to two thirds, depending on the food and will give a traditional finish of an ordinary oven.
Auto Sensor Programs will calculate the cooking time for you. Additional Features includes: Auto Weight Cook, Chaos Defrost, Turbo Bake, Child Lock, Auto Guide.


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Oncolytics Biotech® Announces Publication of Abstracts at the 2020 American Society of Clinical Oncology Virtual Annual Meeting
Clinical response was associated with tumor-specific replication, PD-L1 upregulation, and CD8+ cell recruitment in multiple myeloma patients treated with pelareorep and carfilzomib
Pelareorep and pembrolizumab combination therapy was well tolerated with encouraging clinical results in second-line pancreatic cancer
May 14, 2020, 07:00 ET
SAN DIEGO and CALGARY, Alberta, May 14, 2020 /PRNewswire/ -- Oncolytics Biotech® Inc. (NASDAQ: ONCY) (TSX: ONC), currently developing pelareorep, an intravenously delivered immuno-oncolytic virus, today announced the publication of two abstracts in connection with the upcoming ASCO Virtual Annual Meeting on May 29-31. The first abstract ("Multiple Myeloma Abstract"), which has been accepted as an electronic poster, reports on viral replication, tumor immune responses, and treatment safety in multiple myeloma patients treated with pelareorep in combination with carfilzomib (Kyprolis®). The second abstract ("Pancreatic Cancer Abstract") reports on treatment tolerability and efficacy in pancreatic cancer patients treated with pelareorep, in combination with pembrolizumab (Keytruda®).
Multiple Myeloma Abstract
Abstract ID: 8535
Session: Hematologic Malignancies-Plasma Cell Dyscrasia
Poster ID: 435
Abstract Title: Oncolytic virus pelareorep plus carfilzomib phase I trial in carfilzomib-refractory patients (NCI 9603): Responses with cytokine storm
Presenter: Craig Hofmeister, M.D., MPH, Associate Professor, Department of Hematology and Medical Oncology Emory University School of Medicine
- Reported selective infection of cancerous cells with pelareorep, with associated CD8+ and natural killer (NK) cell recruitment, PD-L1 upregulation, activated caspase-3 expression, and increased pelareorep protein production within myeloma cells.
- Two patients achieved unconfirmed partial responses, two patients had stable disease, and two patients had progressive disease. All patients had advanced and challenging to treat carfilzomib-refractory disease.
- Of the two responding patients, one patient developed a fever and grade 4 thrombocytopenia that resolved, and the other patient developed a cytokine storm, associated with rapid tumor lysis.
- Data supports the potential of future studies investigating pelareorep, carfilzomib, and immune checkpoint inhibitor combination therapy in multiple myeloma patients.
- Additional data to be presented at the poster session on May 29, 2020.
Pancreatic Cancer Abstract
Abstract ID: e16789
Abstract Title: Pembrolizumab in combination with the oncolytic virus pelareorep in patients progressing on systemic chemotherapy for advanced pancreatic adenocarcinoma, a Phase II study
Presenter: Devalingam Mahalingam, MD, Ph.D., Associate Professor of Medicine at Northwestern University Feinberg School of Medicine and a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Preliminary data indicate that the combination of pelareorep and pembrolizumab resulted in tumor-specific replication, a high degree of T cell repertoire turnover, and the creation of new T cell clones in the peripheral blood during treatment.
- The treatment was found to be well tolerated, with most treatment-related adverse events being grade 1 or 2.
- One patient achieved a partial response and three achieved stable disease, with an overall disease control rate of 30% in evaluable patients.
- The study will not proceed to stage 2 in unselected patients, however further evaluation of the anti-tumor activity of pelareorep and anti-PD-1 therapy is now planned in biomarker defined pancreatic patients in a subsequent study.
- Detailed translational and biomarker data from this study will be published later in the year.
About Pelareorep
Pelareorep is a non-pathogenic, proprietary isolate of the unmodified reovirus: a first-in-class intravenously delivered immuno-oncolytic virus for the treatment of solid tumors and hematological malignancies. The compound induces selective tumor lysis and promotes an inflamed tumor phenotype through innate and adaptive immune responses to treat a variety of cancers and has been demonstrated to be able to escape neutralizing antibodies found in patients.
About Oncolytics Biotech Inc.
Oncolytics is a biotechnology company developing pelareorep, an intravenously delivered immuno-oncolytic virus. The compound induces selective tumor lysis and promotes an inflamed tumor phenotype -- turning "cold" tumors "hot" -- through innate and adaptive immune responses to treat a variety of cancers.
Pelareorep has demonstrated synergies with immune checkpoint inhibitors and may also be synergistic with other approved immuno-oncology agents. Oncolytics is currently conducting and planning additional studies in combination with checkpoint inhibitors and targeted therapies in solid and hematological malignancies, as it prepares for a phase 3 registration study in metastatic breast cancer. For further information, please visit: www.oncolyticsbiotech.com.
This press release contains forward-looking statements, within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended and forward-looking information under applicable Canadian securities laws (such forward-looking statements and forward-looking information are collectively referred to herein as "forward-looking statements"). Forward-looking statements, including the Company's belief as to the potential and mode of action of pelareorep as a cancer therapeutic, and other statements related to anticipated developments in the Company's business and technologies involve known and unknown risks and uncertainties, which could cause the Company's actual results to differ materially from those in the forward-looking statements. Such risks and uncertainties include, among others, the availability of funds and resources to pursue research and development projects, the efficacy of pelareorep as a cancer treatment, the success and timely completion of clinical studies and trials, the Company's ability to successfully commercialize pelareorep, uncertainties related to the research and development of pharmaceuticals, uncertainties related to the regulatory process and general changes to the economic environment. In particular, we may be impacted by business interruptions resulting from COVID-19 coronavirus, including operating, manufacturing supply chain, clinical trial and project development delays and disruptions, labour shortages, travel and shipping disruption and shutdowns (including as a result of government regulation and prevention measures). It is unknown whether and how the Company may be affected if the COVID-19 pandemic persists for an extended period of time. We may incur expenses or delays relating to such events outside of our control, which could have a material adverse impact on our business, operating results and financial condition. Investors should consult the Company's quarterly and annual filings with the Canadian and U.S. securities commissions for additional information on risks and uncertainties relating to the forward-looking statements. Investors are cautioned against placing undue reliance on forward-looking statements. The Company does not undertake to update these forward-looking statements, except as required by applicable laws.
Company Contact
Michael Moore
Investor Relations & Corporate Communications
Investor Relations for Oncolytics
Timothy McCarthy
LifeSci Advisors
SOURCE Oncolytics Biotech® Inc.


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How Many Calories Does Power 90 Burn?
Follow Us:
Power 90 is a high-intensity interval training regimen that consists of dozens of individual workouts. The number of calories burned while executing this training regimen depends on the type of individual workout, the duration of the workout, and your body weight, according to P90X Calories.
The Power 90 Sculpt Workout burns 362 calories, according to the Fit Corner Network. The Cardio 1-2 and Ab Rippers 100 workouts burn 474 calories, and the Cardio 3-4 and Ab Ripper 200 workouts burn 945 calories. A more advanced version of Power 90, called P90X, was developed to be even more efficient than Power 90 at burning calories.


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'I'm thankful to be at the right place at the right time': Custodian, fifth grader save child's life
Whether brightening kids' spirits or making them laugh, Kim Deaton seems to always be in the right place for students at Amanda Elementary School in Middletown, Ohio.
Deaton, who's better known as Miss Kim, is the lead custodian at the school.
"These kids might be somebody else's kids, but for eight hours a day, they're mine, and it's my job to protect them," Deaton said.
Deaton saved a life Thursday with help from 11-year-old O'brianah Moon. The fifth-grader was sitting at the lunch table with her classmate, Cole.
"He took a bite of his cheese stick, and his face started turning red. He wasn't answering my questions," O'brianah said. "He started shaking a lot, and when he started shaking, I knew there was a problem."
O'brianah stayed calm.
"I knew that Cole was going to be OK because he's very brave. He's a very brave kid," she said.
At the same time, O'brianah yelled for Deaton who was across the room.
"I take off running, and I go over and by the time I get there, he's very, very red, and he can't move any air at that point, like there was nothing coming out. I said, 'I love you but I'm sorry. I'm going to hurt you because you can't talk back to me, and I picked him up and I gave him the Heimlich maneuver. After a couple of thrusts, we got one piece out," Deaton said.
Cole still couldn't talk.
"So, I did it again a couple more times, and we got all of it out, and he's here today," Deaton said. "It was scary, very scary, but to know that these kids all stepped up, a room full of kids all stepped up and did the right thing. One did exactly what I told her to do and get the nurse. The other kids quieted."
O'brianah stayed by Cole's side.
"I was sitting there making sure he was OK because I was very scared for him," O'brianah said.
Deaton said she was trained as an EMT years ago and that training just kicked in.
On Friday, students and staff at Amanda Elementary thanked Miss Kim. One boy even gave her a Valentine that said, "You're magical."
"The outpouring of love has been so overwhelming. I cry a lot, but I'm thankful. I'm thankful to be at the right place at the right time," Deaton said.
Aside from him having a little sore throat, Cole is doing fine. He spent Friday resting at home.


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Getting Ahead in the Startup Game
There are many different ways to get ahead of the startup game by getting the funding you need. One that is used often is asking family or friends to borrow money to start the funding of your company.
They most likely believe in your vision more than a bank. Beware that it can also cost you friends and sever ties with family if not done properly. In this day an age crowdfunding is a good platform to use. There are many different companies and even more projects to be funded.
This means you must work harder to advertise your idea. Bootstrapping is another route people go. Using your savings to fund your business could be the easiest way but if your business fails you will be stuck with the debt.
Options to Fund Your Startup
There are some interesting routes for your startup. There are newer ways and classic ways. There are even ways people might not even know about. Here are a few you could look into.
Local contests are an interesting route. We've all seen Shark Tank and while getting on that show isn't really likely, there are smaller contests that aim to help local businesses strive. These local contests won't cost anything and even if you're not picked it can easily spread the word of your business.
Trading services is an interesting route that many small and large businesses use. Say you're a writer and you need a web designer. Well, you know one and he might need a freelancer for something. You could exchange services and save money for both of you.
Traditional Routes to Fund Your Startup
With so many ways to get your startup off the ground, there are many classic options to look at. One of the main things to do before bringing your idea to an investor or bank is to have a detailed business plan already thought out. Without a business plan, no one will take you seriously and make sure your financial projections are realistic.
A local bank is a good place to start. The best bank to start with is your personal bank. You already have built a relationship with them so it will make it easier for them to want to work with you and provide you with the best small business loans.
Plus, if they do deny the small business loan you could always try to get a longer personal credit line with them. If used responsibly, you will be able to start your business with a credit card. Try not to only pay the minimum and don't miss payments.
A microloan is like a small business loan but starts at $500. These are the loans banks refuse to waste their time with so you can get them from a microlender. These non-profits offer small loans with less documentation and more flexible criteria. They usually have higher interest than banks though.


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Tides and Terroir at Anchovies & Olives
Ring in Seattle springtime on Sunday, May 18 with a divine afternoon of oysters and rosé at Anchovies & Olives. From 1pm to 4pm chef Zach and the A&O gang will be shucking oysters and pouring rosé, toasting to the warm months ahead.
Over the course of the afternoon, guest can taste six to eight varieties of oysters from the Puget Sound and British Columbia and eight rosés. The range of summery rosés pairs up perfectly with the selection of sweet to briny oysters—wine director Justin Rosgen will be on hand to talk about the wines as the afternoon progresses. The rosés will be available by the half-glass, glass, or bottle—plus deals on bottles to take home.
Here's a peek at the oysters that will be on offer:
Prices are by 6, 12 or 24
$18/ $30/ $60
Flapjacks (South Sound)
Barron Points (Hood Canal)
Sea Cows (South Sound)
Blue Pools (Hood Canal)
Premium Oysters
$20/ $35/ $70
Shigoku (Southwest Washington)
Kusshi (Vancouver Island)
There will be a scallion mignonette, classic red wine mignonette, and fresh grated horseradish with lemon to accompany the oysters.
Prices are by the half-glass, glass, and bottle
2013 Maculan Rosato (Veneto, Italy) $5/ $9/ $34
2013 Syncline Rose (Columbia Valley) $6/ $11/ $37
NV Charles Ellner Cuvee de Reserve Rosé (Epernay, France) $100
2013 San Giovanni Chiaretto Rosé (Lombardia, Italy) $6/ $11/ $37
More selections to come!
The patio will be open and hopefully the sun will be out—come spend a lovely afternoon on 15th Avenue with oysters and wine! Reservations are recommended but not required—and can be made online or by calling 206.838.8080.


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Notes in the Margins: Tommie-Johnnie tees, terrorism and transgender athletes
Sexual Violence Survey The Minnesota State Colleges and Universities Sexual Violence Policy will be reviewed in Spring 2011, and the Minnesota State University Student Association would like to research how the policy affects students. Students are encouraged to fill out a survey. (msusa1967.blogspot.com)
College student tackles suspect in Alexandria police pursuit A police chase ends when a bystander -- a law enforcement student at Alexandria Tech -- tackles the suspect. (ksax.com)
Families are trimming plans to pay for college American families are scaling back plans to pay for their children's college education as the stunted economic recovery continues to weigh on household budgets, according to a survey to be released today that was commissioned by college lender Sallie Mae. (The Washington Post)
Tyler Clementi's Suicide Resonates On Campus, Beyond Just as the murder of Matthew Shepard galvanized the gay community around hate-crime legislation more than a decade ago, the suicide of a Rutgers University student whose sex life was splashed on the Internet has activists rallying around their latest cause: telling tormented gay teens they just need to hang on for a while, that they'll live through it. (Huffington Post)
Before you keep reading ...
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SLIDESHOW: Although banned, T-shirts and party buses still show up in Collegeville Even after the bans on party buses and inappropriate T-shirts at the Tommie-Johnnie football game, some students still rode party buses at least part of the way to the game, and some students snuck forbidden T-shirts into the stadium. (tommiemedia.com)
Mid-Atlantic Christian University Shooting Leaves One Dead A shooting Sunday afternoon at the Mid-Atlantic Christian University, formerly Roanoke Bible College, left a student dead. (Huffington Post)
After Travel Alert for Europe, American Colleges With Students There Are Wary They've passed along the State Department's caution about possible terrorist attacks and fielded questions from anxious family members. (chronicle.com)
College Sports Programs Should Protect Transgender Athletes, Report Says A new report from the National Center for Lesbian Rights and the Women's Sports Foundation calls on collegiate sports programs to adopt a uniform policy that bans discrimination against transgender athletes. Such a policy would replace the patchwork of state laws that currently protect transgender students from discrimination. (chronicle.com)
Missouri Campuses Are Asked to Account for 'Low-Producing' Degree Programs The Missouri Department of Higher Education has given the state's public colleges and universities an October 21 deadline to explain what they will do with programs that produce few graduates. (chronicle.com)
British Universities and Businesses Are Forming Stronger Research Ties As collaborations between higher education and industry become more common, programs and incentives are needed to foster this activity, a new report finds. (chronicle.com)
Families can better afford college if they strategize early Many don't save enough if at all, a survey finds. Taking AP tests and applying to community college can help students cut back on costs. (USA Today)
Virginia fight over climate documents will continue The University of Virginia and an embattled climate scientist said Monday that it would continue to fight state Attorney General Ken Cuccinelli II's efforts to obtain documents related to a climate scientist's work, just hours after Cuccinelli reissued a civil subpoena for the papers. (feeds.washingtonpost.com)
A For-Profit Institution Sues a Public-College President, Alleging a Smear Campaign In a further sign of the heightened tensions over proposed new federal regulations on for-profit colleges, Keiser University, a Florida-based for-profit, has sued a public-college president there, accusing him and a top administrator of smearing Keiser by communicating derogatory comments about the for-profit education industry to investors and others via e-mail. (chronicle.com)


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A few nights ago I caught a late night re-broadcast on CNN about the NY Philharmonic's "historic" (read: trying too hard) concert in Pyongyang, North Korea. It struggled to explain — through various melodramatic story lines — how this was a moment for Art. But I kept wondering if it was actually just a moment for The Arts?
To understand the difference, I ask that you read this wonderful essay just posted by critic, musician and arts consultant Greg Sandow on a BLOG for this year's National Performing Arts Convention in Denver, CO. (The convention kicks off in early June.)
It's a bit long-winded but remember this is a BLOG not a formal printed essay — there is a difference — and that this is a point that has to be hammered into the brains of arts presenters and classical music aficionados in much the same way that you might struggle to explain punk rock to your grandparents.
So why am I telling this story? To introduce my thought that art and the arts aren't the same thing. Art is an activity, sometimes sublime, and also the result of that activity. By now we know – or certainly we ought to know — that it might be found anywhere, in vacant lots, in silence and graffiti, in overheard remarks (see the poetry of Jonathan Williams, an advocate of outsider art, who died not long ago), and in popular culture. The arts, by contrast, are a set of interest groups, whose claim to glory (and to funding) is that they speak for art, which is only partly true. They don't speak for all art, and when someone speaking for the arts – by which I mean for the interest groups – says that only the arts can offer meaning in our society, we've strayed so far from reality that we might as well be jumping off a cliff. Especially if we're looking for a younger audience!
Here's an example. Dana Gioa, the chairman of the NEA, gave a widely circulated commencement speech at Stamford, in which (among much else) he longed for the good old days, when art was in its glory, and opera singers like Robert Merrill could be heard on network TV. But Robert Merrill didn't have a brain in his head. I can say this affectionately, because I love opera, and Merrill can ravish me with his voice. But he had nothing to say in his singing (something that certainly was noticed back in the day), and to imagine that putting him on TV brings art in all its glory to an audience of millions is really pretty funny. Contrast what happens now, when we have pop stars like Bruce Springsteen, who write their own words and music (something Robert Merrill couldn't do), who sing about serious things, who both reflect profound things in our culture, and influence them (see for example the book about Springsteen – Springsteen's America: The People Listening, a Poet Singing — by Robert Coles, one of our most profound and literate psychologists). And who go on 60 Minutes, talking about society and politics, in a completely serious, compelling way. Is that a step backward? I'd call it a big step forward, at least if you want art to mean something, and to help form both our consciousness and our reality.
But wait! How can Springsteen be an artist, if he's a pop musician, and therefore (horror! horror!) commercial? To me that question is based on a misunderstanding both of commerce and of art. Or at least of the history of art. My field is classical music, and you can't study its history without noticing that many great musicians of the past were commercial, including many of the great composers, or maybe even most of them. I've just been reading a lively little book – Liszt: My Travelling Circus Life, by David Lee Allsobrook — about one of the greatest pianists of the 19th century, Franz Liszt, and his two tours of England in the 1840s. He made those tours purely for money, flacked for a piano manufacturer, whose pianos he endorsed, and packed his programs with popular opera arias and comical songs, all to please an audience that would have run away from more serious music, by the likes of Mozart or Beethoven.
… Why was commerce, for an artist, OK in past centuries, but bad in this one? Someone's going to say that our culture has degenerated, but I don't buy it. Things were better in the days of slavery? Should we look back with admiration at an age when women were their husbands' property, just because people (or so we think) liked better music then? Picasso knew exactly how to sell himself. Should we condemn his art?
… Orchestras and opera companies, not to mention big classical record labels and classical radio stations, are terrified of their audience. They're afraid to program things that their audience won't like. Yes, they do it sometimes, but they always know that some large part of their audience might not like anything new or adventurous – and that it would be commercial (that word again) suicide for them to do too much of that.
After the jump, more proof that Art can be found in the places you'd least expect!
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