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FDA-approved drugs eliminate, prevent cervical cancer in mice
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have eliminated cervical cancer in mice with two FDA-approved drugs currently used to treat breast cancer and osteoporosis.
Published in this week's (Nov. 9) Proceedings of the National Academy of Sciences, the findings offer hope for the 500,000 women around the world who are diagnosed with cervical cancer each year. Half of them will not survive.
The drugs, which keep estrogen from working in cells, also cleared precancerous growths, or lesions, in both the cervix and vagina, and prevented the onset of cancer in mice that had the precancerous lesions.
"We have begun to test whether the drugs are as effective in treating cervical cancer in human cells as they are in our mice," says senior author Paul Lambert, of the McArdle Laboratory for Cancer Research and the UW-Madison Carbone Cancer Center.
The lab studies, which should take one or two years to complete, could be followed quickly with phase-two or phase-three clinical trials. Early phase trials would not be necessary since the drugs have already been approved for clinical use.
Lambert and his team use special mice they developed more than 20 years ago to study cervical cancer. The mice were genetically engineered to carry human papillomavirus (HPV) 16, known to be strongly associated with cervical cancer.
HPV is also the most common sexually transmitted infection in women in the United States. While new vaccines can prevent some of the many kinds of HPV infections, they do not eliminate already-existing infections or cervical cancers or precancerous lesions arising from pre-existing infections.
"Virtually all cervical cancers in women test positive for HPV 16," says Lambert, a professor of oncology at the UW-Madison School of Medicine and Public Health.
But not everyone who becomes infected with HPV gets cervical cancer, so scientists have suspected that something else was going on.
"Since the cervix and other female reproductive organs are so responsive to estrogen, our lab and others began to focus on that hormone," Lambert says.
Sang-Hyuk Chung, a postdoctoral fellow in Lambert's lab, zeroed in on one of the two receptors that mediate estrogen function in cells — estrogen receptor (ER) alpha. He crossed his HPV mice with mice in which ER alpha had been knocked out, then gave the animals estrogen. When the mice didn't develop cervical cancer or even precancerous lesions, Chung knew that ER alpha was an essential player in the slow cancerous process.
"We then wanted to learn if drugs that interfere with the receptor and block estrogen's ability to bind to it could be used to treat or prevent cervical cancer," he says.
Chung turned to an ER alpha blocker used to treat breast cancer, fulvestrant, and tested it on the HPV-positive mice with cervical cancer. After one month, he found that 11 of 13 mice lost all signs of cancer. But cancer remained in all the control mice that hadn't gotten the drug.
"It was amazing to see that not only was the cancer gone, but all the precancerous lesions that give rise to cancer were also gone," says Lambert.
Chung then tested a second drug, raloxifene, which is used to treat breast cancer and osteoporosis, to make sure that the first results weren't a fluke. He found the same strong, blocking effect.
Finally, the researchers gave the drugs to animals with the precancerous lesions and found that the ER alpha blockers prevented the lesions from progressing to cancer.
Lambert's team is now testing human cervical cancer cell lines to see if ER alpha blockers stop the growth of the malignant cells. The next step will be to test the drugs on tissue samples removed from women following surgery for the cervical cancer.
"We can't be sure how the science will translate from animals to humans," says Lambert, "but we have faith in our mouse model. There are many similarities in how cervical cancer develops and manifests itself in women and in mice."
Source: University of Wisconsin-Madison (news : web)


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The New World Progresses, Where the Wealth is, and Venezuelans Destinations
We raise a new and troubling trend that we need your help to understand. We talk, of course, about waiters' insistent desire to take our plate away before we are finished eating. This happened again to us last night. Interestingly, we were at a private club not a restaurant. We once assumed restaurants do this in an effort to turn tables more quickly and bring in more revenue. But we're not sure what the incentive is for a private club to do this. At any rate, it has been happening more and more frequently over the last year. Food will still be on our plate, we may be engaged in conversation with our meal mates, and the waiter, often without even asking, will whisk our dish away. So why are restaurants and even private clubs doing this? Is there a plate shortage we are unaware of, perhaps a result of one of the many trade wars the United States has engaged in? Perhaps it's just a corporate fad, making no sense, like the open office craze that swept work places for a few years. Or maybe there is something more deep and mysterious occurring, some X-Files scenario. Or perhaps it is foreign interference into American dining morés or even some secret society of wait staff engaged in a revolt against the eating masses? Whatever the cause, we aim to get to the bottom of it and stop this madness. While we await your theories, we offer a dish of the new world, an entrée of where the world's wealth is and an unappetizing dessert of the Venezuelan diaspora. It's this week's International Need to Know, your maître d' to a world of information and data.
We will be speaking in Spokane next week to the Washington Public Ports Association and then off to Vietnam for a week. INTN will return on Thursday, May 30th.
Without further ado, here's what you need to know.
The New World Progresses
With the abdication of leadership in the world by the U.S., the rest of the world adapts and adjusts accordingly like the Golden State Warriors without Kevin Durant. This week brings word of Japan and Vietnam forming new alliances to address China's South China Sea ambitions. The Japan Times reports that last week Japan and Vietnam's Defense Ministers met in Hanoi and announced the two countries "will work together to peacefully resolve the issue of China's rapid expansion in the South China Sea." The two countries more generally are deepening their alliance to address a host of security and policy issues. The two countries signed a Memorandum of Understanding to cooperate on "maritime security, humanitarian assistance, disaster relief and cybersecurity." We are interested in whether our new world will be safer and more peaceful than the old one. But either way, it is happening.
Where the Wealth is (Our Underrated Country)
Over the last ten years, where is wealth congregating? Or as VisualCapitalist phrases it, where are the best and worst performing wealth markets in the world, defining "wealth market" as "the total assets owned by individuals within a jurisdiction." You will not be surprised that China tops the list but the number three country for wealth markets over the last ten years is, yes, our favorite underrated country, Ethiopia, which saw a 102 percent increase since 2008 in the size of its "wealth market." Number 2 Mauritius is probably surprising too. India is a no-brainer for this list as is Vietnam (where we are headed in a week). The worst performing market is not surprising either—nice work Venezuela.
Venezuelan's Destination
Speaking of Venezuela, that slow burning trash fire has led to a diaspora. Where are Venezuelans fleeing to? Check out the Council on Foreign Relations handy map below. With 1.1 million, Colombia is home to the largest group of fleeing Venezuelans, followed by Peru, the United States and Ecuador. Simon Kuestenmacher tells us that about 10 percent of Venezuela's population has fled the country in the last three years. Venezuela was once a prosperous, stable country. We hope it will be again someday.

subset: commoncrawl


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Maccoby sets out his intentions in the Preface.
I have used the rabbinical evidence to establish... that Paul, whom the New Testament wishes to portray as having been a trained Pharisee, never was one.In this undertaking there would be few more qualified than Maccoby, a Fellow of Leo Baeck College, London and a specialist in the relationship between Judaism and Christianity.
And later.
I have returned to one of the earliest accounts of Paul in existence, that given by the Ebionites, as reported by Epiphanius.This then is a unique brief, but clearly not one that should be regarded as beyond the pale.
With the first chapter, The Problem of Paul, we get an interesting angle on the apostle. Maccoby is neither a Christian nor a Christian apologist, and he isn't even faintly interested in politely genuflecting in that direction.
Paul claimed that his interpretations were not just his own invention, but had come to him by personal inspiration; he claimed that he had personal acquaintance with the resurrected Jesus, even though he had never met him during his lifetime. Such acquaintance, he claimed, gained through visions and transports, was actually superior to acquaintance with Jesus during his lifetime...Anybody want to argue that one?
The erasure of James and his brothers from prominence in the gospels indicates for Maccoby that the ground had shifted. These people, who actually knew the Jesus of history, regarded Paul as an upstart and his gospel as a misrepresentation.
Paul is said to have hailed from Tarsus, but this is something he is reticent about revealing in his own writings.
The impression he wished to give, of coming from an unimpeachable Pharisaic background, would have been much impaired by the admission that he in fact came from Tarsus, where there were few, if any, Pharisee teachers and a Pharisee training would have been hard to come by.Maccoby is asking, basically, if Paul cooked his CV.
The fact that this question is hardly ever asked shows how strong the influence of traditional religious attitudes still is in Pauline studies. Scholars feel that, however objective their enquiry is supposed to be, they must always preserve an attitude of deep reverence for Paul, and never say anything to suggest that he may have bent the truth at times, though the evidence is strong enough in various parts of his life-story that he was not above deception when he felt it warranted by circumstances.Them is fighting words, but it's a relief to see somebody putting it out there in plain language. Those who have paddled in the academic puddles of theology know that this is a pretty fair summation of the situation - and degree programmes at secular universities (and yes, I'm remembering classes at Otago) are far from exceptions.
Only in six pages and my appetite was well whetted.
More from the first chapter next time.


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My Story
6 Years Of Facebook Chat For Hours & 2 Meetings. I Fell In Love With Him But What He Did Broke Me
That evening of 2012 was just like any other evening and as I logged into my Facebook account, I saw a message from a stranger named Samar. I checked his profile and don't know what attracted me that I replied to his message. It was a normal chat session initially and slowly our interaction increased day by day.
I was pursuing graduation and he was a manager in a multi-national company. We used to chat for 4-5 hours daily and there were all elements in our conversation – humour, romance, emotions and what not!
We used to share almost everything including little stuffs and for the first time, I had a friend who actually wanted to listen to me for hours, no matter whether I kept on talking senseless things. We often used to flirt with each other and I didn't realise when I actually fell in love with him. There came a time when we felt that we both can't live without talking to each other. I used to wait for him to come online and then chat for long every day.
Two years passed like that and I felt that he has a special place in my life but my bad, I couldn't even express my feelings to him because he already had a girlfriend Shalini at that time.
His girlfriend knew about me and thought that there was something between me and Samar. It was not her fault and anyone would think likewise after seeing our hours-long conversations and that too in day and night. What's more, Samar and Shalini didn't interact that much and she felt that Samar avoided him because of me. She broke up with him and he was upset.
After that unfortunate incident, he stopped chatting so much and I also didn't ask any question for obvious reasons. Their relationship was three years old and he was missing her. I tried my best to cheer him up and finally he came out of her memories.
One more year passed and after talking to him for 3 long years on Facebook, I got a chance to meet him for the first time when he came to Delhi from Jaipur in January 2015. It was a big day for me and I wore a beautiful pink dress, as pink was his favourite colour. He was more handsome in real life than what he looked like in the pic. We talked for a couple of hours and had lunch. He had to go the same day so we bid each other good bye.
In July in the same year, he had to go abroad and since his flight was from Delhi, we met once before he went. In that meeting, I wanted to hug him and express my love but he formally extended his hand for a handshake. How could I hug him when he himself behaved so formally?
He left but we used to interact as usual. After few months, his behaviour was changed and I felt as if he was ignoring me. He said that he was occupied with work and our chat sessions got shorter. Sometimes he didn't use to reply for days and when did, his replies gave an idea as if he didn't want to talk. The more I tried to talk, the more he ignored me.
18 months passed and his rudeness was getting intolerable. One day, I proposed to him and thought that he would surely say "YES". But contrary to my expectations, he got extremely angry as if he didn't have any idea of what I feel about him. I couldn't believe that he behaved so rudely and this broke me into pieces. He asked me not to send him any message and we didn't talk after that.
But I didn't lose hope and became friends with his best friend via Facebook so that I could know more about him. While chatting, I made him reveal some secrets and he told me that Samar had a crush on one of his colleagues there.
So this was the real reason as to why he started ignoring me and gave me less time. Now I could understand the sudden change in his temperament and his fury when I proposed to him. He got married to her last year in December and I still cry remembering him. I lost my friend by proposing to him but that was bound to happen.
I rejected many boys in this period and last month when my parents asked me the reason, I told them everything about Samar. I don't want to cheat any man because I can't fall in love again and if I tie knot with some guy knowing that I would not be able to give him that love, it will be a deception.
Many of you might call me a fool because I didn't move on but everyone can't let go things easily. Probably one day I will also be able to accept someone in my life but presently, he's in my life, no matter whether he threw me out of his life.
If you too have any such story to share with us, mail us at [email protected] We would love to hear from you. RVCJ has recently started My Story section in which our users can share their stories without having to reveal their identity. Many people have problem but they are not comfortable while sharing it. Your story may help someone come to a better conclusion. RVCJ will publish one story daily at 10 PM.


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The "Run 4 Tigers" event is the 12th annual half-marathon race organised by the Red River Runners club in collaboration with Sporting Republic and the local NGO Education for Nature - Vietnam (ENV), aiming to raise funds for activities to protect the wildlife in Vietnam.
In addition to registration from individuals, there were groups coming from agencies, enterprises and diplomatic missions in Hanoi participating in this year's race, along with the joining from celebrities such as Miss Vietnam 1994 Nguyen Thu Thuy and MC Mai Trang from Vietnam Television.
Runners show their commitments to protect tigers.
Jody O'Dea, a representative from Red River Runners, expressed his delighted at the support of the runners to the event, saying that it shows public attention and desire to protect tigers from extinction risk.
The demand for tiger products has caused the wild tiger population in Vietnam and other countries in the region to decline sharply in recent decades. Scientists estimate that Vietnam currently has less than five tigers in the wild. The biggest threat to tigers in Vietnam is the illegal hunting and trading of tigers, as well as the loss of their habitat. Tigers are mainly traded for bone to make traditional medicines.
The race attracts a large participation from individuals and groups.
Nguyen Thi Phuong Dung, Deputy Director of ENV, said the extinction of the one-horned rhino in Vietnam in 2010 was a great loss, stressing the need to take actions to protect tigers before it is too late.
"The best way to protect tigers is to let them live in a natural environment. This is also the message that this year's run wants to convey to the community," Dung stressed. She also called for the community to join the efforts by not using any product from tigers and report violations to authorised agencies or the ENV free hot line for wildlife protection at 1800 1522.
Miss Vietnam 1994 Nguyen Thu Thuy (C) joins the race for the first time.
Interactive activities at the event attract multiple attendees.
Signing to commit to tiger protection.


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Israel Destroys Hamas-Built Terror Tunnel Under Gaza Border
by Reuters and Algemeiner Staff
Israel destroyed a cross-border tunnel on Thursday running from the Gaza Strip into Israeli territory, which it said was dug by the Palestinian Hamas group with the aim of carrying out attacks.
There was no immediate comment from Hamas, which has fought three wars with Israel in the past decade and is the dominant Palestinian armed force in Gaza, where an Israeli security fence runs along the frontier.
"In the past few hours our forces have neutralized a terrorist attack tunnel belonging to the Hamas terrorist organization, which penetrated Israel from the central Gaza Strip," a military statement said.
Israeli military spokesman Lt. Col. Jonathan Conricus told reporters on a conference call that the tunnel, which he said was the 15th detected and destroyed in the last year, ran 200 meters into Israeli territory.
Related coverage
Earlier on Thursday, the army said rocket alert sirens that had sounded in Israeli communities near the border with Gaza were a false alarm.
Palestinian gunmen used tunnels to blindside Israeli forces during the 2014 Gaza war. Israel has since been developing detection technologies and laying down an underground wall which will remove the threat posed to Israel by these tunnel by 2019.
Tensions at the Israel-Gaza border have remained high after a brief eruption of fighting that included Palestinian rocket attacks and Israeli air strikes ended in August.
Palestinians have been mounting weekly demonstrations at the border which have included violent attempts to breach a security fence. Israeli troops have killed at least 195 Palestinians since the disturbances began in March, Gaza medics say, and one Israeli soldier has been killed by a Gaza sniper.
Citing security reasons, Israel and Egypt maintain tight restrictions on their borders with Gaza, home to two million Palestinians.
Egyptian efforts to mediate a long-term ceasefire between Hamas and Israel has so far shown little progress.
As part of a U.N.-backed effort to alleviate hardship in Gaza, Qatar has donated fuel to provide for Gaza's power plant for six months. Delivery of the fuel began earlier this week.
Doha has also announced a $150 million emergency aid package for Gaza.


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We're lovin' McDonald's Moving Day ads
The QSR and Cossette used box illusions to recreate delectable menu items.
In Canada, July 1 is about drinking beer, BBQs and fireworks in celebration of Canada Day. But for many Quebecers, July 1 is also Moving Day – which means packing boxes, moving boxes… and Micky D's?
McDonald's Canada understands Moving Day and comfort food go together just as well as Prime Minister Justin Trudeau and wife Sophie Grégoire Trudeau.
About 100,000 Montrealers were expected to move on or around July 1 this year, according to the Montreal Gazette. So McDonald's teamed up with Cossette to target those hungry Moving Day movers with a series of ads that used that one item we all use when moving: boxes. We're lovin' the use of brightly coloured boxes to depict some of McD's most iconic menu items, along with the words: "Bon Déménagement," en français et "Happy Moving Day" in English.
The bright yellow and red boxes instantly made our mouths water with the thought of the fast-food chain's delish fries.
The white and brown boxes conjuring up ice cream atop a cone makes this Stim writer want to rush to the Golden Arches. Right. Now.
But the brown boxes (presumably depicting a McCafé cup) is a bit harder to decipher. It's kind of like a Magic Eye, if you look long enough the cup will emerge. Trust.
Advertiser: McDonald's Canada
Agency: Cossette
Creative team: Alexandre Jutras, Anne-Claude Chénier, Barbara Jacques, Patrick Michaud, René Lachapelle


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cat – concatenate files and print on the standard...'cp' command in linux
cp - copy files and directories. Format: cp [options] source...'kill' command in linux
kill – it is used for stopping processes ...'mkdir' command in linux
mkdir – create one or more directories Format mkdir [options]...'mv' command in linux
mv – renames and move files Format mv...'ps' command in linux
ps - gives a snapshot of the current running processes. ...'rm' command in linux
rm – removes a file or directory ...'w' command in linux
w - shows which all users logged in and what they are...How to find files in linux through the command 'find'?
find – searches for a file in directory hierarchy. ...How to login to remote machine through 'ssh' command?
ssh - is a program for logging into a remote machine and for...How to set a cronjob in linux?
crontab - it is used for scheduling jobs, commands etc.The entry consist of...The 'useradd' command in linux
useradd : it is used to add an user ...The best compression method in lunux.
The best way to compress the files and folders to use the command bzip2. ...The command to change the file attributes.
chattr - change file attributes Format: chattr [-RV]...The use of rpm command in linux.
rpm(redhat package manager) rpm – installer...Use of sudo command in linux
sudo - execute a command as another user. Format: sudo [options]...command to change the access permissions in linux.
chmod – change the access permissions. ...command to set file access control list.
setfacl - it is used for granting read,write,execute access to files and...command used to archieve files and directories into a single file.
tar – it is used for archieving files and directories into a single file ...command used to compress files in linux.
gzip,gunzip – compress or expand files. ...for what purpose the commad 'du' is used for?
du- estimates the file space usage. Format: du [options] [file]...for what the command 'tail' is used for?
tail – print the last 10 lines of the named file.If more than one file is specified...purpose of 'touch' command
touch - changes the date and time of the file to the current date/time.If the file...su command in linux.
su - run a shell with substitute user and group...what is the command 'ls' used for?
ls – list directory contents. ...what is the use of command 'grep'?
grep- search one or more files that matches a regular pattern Format:...


text: Urinary Tract Infection Treatments Online Doctors View Larger Image Speak with Doctor Online Today! Get a Prescription Refill today! Need to speak with a Walk in Clinic Online _ org Medical Doctor – Get started with the button to the right –> Speak with a Medical Doctor Online about Urinary Tract Infections today! UTI Online Treatments, Urinary Tract Infection Diagnosis Online Urinary Tract Infections, Types, Treatments, Medications UTI (Urinary tract infection) According to anatomy, the urinary tract is a series of body parts through which the urine goes through thus from the renal pelvis towards out of the body system. The urinary tract infection is a medical problem that is abbreviated as UTI as it's an infection to the urethra, bladder, kidney as well as the bladder. Individuals affected by the urinary tract infection have several different symptoms but the most common one is the burning sensation while urinating as well as having more trips to the urinal. The following are the three different types of the urinary tract infection (Bladder, urethra and the kidney infection) accompanied with their respective urinary tract infections symptoms and treatment. Urinary tract infection of the urethra (Urethritis) This is a type of the urinary tract infection where the human's urethra is inflammation, Urethra is the tube-like channel responsible for taking urine to the outside from the bladder, This infection can be acquired via vaginal sex, anal and oral sex, although at times it can be acquired outside the sex realm. Symptoms of Urethritis. White or at times clear discharge out of the penis. Burning feeling when urinating (this can happen with or without the discharge) Swollen and painful testicles this is mostly when it's at its advanced stage. Urethritis treatment is through a prescription of antibiotics from a doctor, it's not advisable to stop taking the antibiotics even when the symptoms are gone. Urinary infection of the bladder (Cystitis) This is an infection of the bladder, Bladder is that bag like muscular in nature that is responsible for storing urine which comes from the kidney, and this organ is adjacent to the bladder. Cystitis comes by when a bacteria most likely the E.coli that infects causes an inflammation to the bladder as a result of the urine infection from this micro-organisms. It's believed that almost every woman gets infected with Cystitis in their lifetime. The infection is easily spread through sexual intercourse. Symptoms of Cystitis Urine with a very strong smell Bloody and at times cloudy urine.Severe pain in the lower abdomen scalding feeling when urinating. Cystitis can be treated through the intake of lots of water, intake of urinary alkaliser in water. If the symptoms persist consult your doctor on the best course of antibiotics to take. Urinary infection of the kidney (Acute Pyelonephritis) This type of the urinary tract infection that affects your kidney. Pyelonephritis often starts from the bladder as it moves to the kidneys either both or one of them. Rarely does this lead to complicated health problems as its treatment is helpful in preventing the occurrence of this complications. Symptoms of Pyelonephritis The symptoms of this disease are dependent on several factors such as age and gender the most common symptoms include:Experiencing chills. Having fever and having a painful feeling when urinating.Depending on the level of your infection your doctor will know the right course of antibiotics to prescribe for you as plenty of liquids are recommended to help the body dispose of the infection causing micro-organism out of your system. Getting treatment for urinary tract infections online: Speak with an online doctor about your urinary tract infection symptoms today! Antibiotics Prescriptions Refills NSAIDS Prescriptions Refills Impetigo Back Pain Treatment Online Levitra Prescription Online Valtrex Prescription Online Urinary Tract Infection Treatments Online Doctors Skin Rashes Prescriptions Online Doctors Shingles Valtrex Treatment Online Doctors Viagra Prescription Online Thyroid Conditions Levothyroxin Synthroid Herpes Get a Prescription Online Flu Tamiflu Erectile Dysfunction Viagra Cialis Levitra Digestion Prevacid Nexium Sore Throat Cold Sores Cialis Prescription Online Cholesterol Zocor Lipito Chantix Prescription Online High Blood Pressure Athletes Foot Asthma Acne STD TESTING AND TREATMENT STOMACH FLU TREATMENT SINUS INFECTION – Sinusitis STREP THROAT PINK EYE PRESCRIPTION REFILLS EAR INFECTION Common Cold BRONCHITIS ASTHMA ALLERGIES ARTHRITIS Hypertension Los Angeles California Speak with Doctor Online for Urinary Tract Infections, Pelvic Discomfort Today! Get a Prescription Refill today! Need to speak with Walk in Clinic Online _ org Online Medical Doctor about urinary tract infections, pain discomfort pelvic region – Get started with the button to the right –> Speak with a Walk in Clinic Online_org Doctor about Urinary Tract Infections Treatments By admin| 2017-11-27T00:21:03+00:00 April 7th, 2017|Online Prescription Medical Services|0 Comments Share This Story, Choose Your Platform! FacebookTwitterLinkedinRedditTumblrGoogle+PinterestVkEmail


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Desanding or desilter plant is design for bored pile on construction with economy option and very compact design for small footprint. The desanding plant is design for flexible working and installation to suit bored pile, TBM or HDD mud recycling system.
The main components of all desanding plants are: Coarse screen for intercepting stones larger than 5 mm;Storage tank of the coarse screen;Cyclone with cyclone feeder pump for removing fine particles from the suspension; Dewatering screens for abstracting further water from the solids dis-charged by the cyclone.
Desanding plants are employed to remove soil partcles in drilling muds and support slurries used in foundation engineering. They can be either water-bentonite, water-polymere, or water-cement and bentonite suspensions.


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Watch the video click the link down here
#Anal, #Black, #Blonde, #Blowjob, #Busty, #Clips, #Interracial, #Realitykings, #Threesome
Georgie Lyall, Kiki Minaj – Sneaky Salon
Whenever sexy stylists Kiki and Georgie's salon is empty, they keep their hands busy by squeezing each other's big tits and playing with their pussies. When an early client interrupts their quickie, these sexy British birds don't want to stop their fun just yet, but if they're sneaky enough, they can get off behind her back…and with her boyfriend! Kiki and Georgie install their brunette customer under the dryer, then offer her boyfriend Jordi a massage while he waits, and their skilled fingers soon close around his big cock. With one pale blonde and one ebony stunner sucking his dick and riding him, soon Jordi is the one giving the pretty beauticians a facial!


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Julie D. Pfaff
Julie assists businesses and individuals in the avoidance and resolution of disputes through negotiation, mediation and/or litigation. She has more than 15 years of practice experience handling construction claims, environmental compliance issues, and commercial litigation.
Julie has represented Fortune 500 companies, state agencies, mid-sized companies, small businesses, and individuals in a variety of litigation and environmental matters including contract disputes, construction defects, stormwater management issues, and other matters.
Julie was born and raised in suburban Philadelphia. Prior to joining Venzie Construction Law, she practiced civil litigation at a large Philadelphia firm and then moved to a smaller suburban firm where she handled commercial litigation, and client matters involving environmental law and municipal law. In addition to her law practice, Julie is an adjunct professor at West Chester University teaching business and commercial law, employment law, and public speaking.
When she's not practicing law, Julie enjoys spending time with her husband and three children on their farm in West Chester, Pennsylvania. She also enjoys running, gardening, watching Villanova basketball and attending her children's' sporting events.
Prior Employment
- Clerk, Honorable Juan R. Sanchez, US District Court for Eastern District of Pennsylvania
- Associate, Schnader, Harrison, Segal & Lewis
- Associate, Gawthrop Greenwood
- Contract Attorney, Buckley, Brion, McGuire & Morris
- American Bar Association
- Forum on the Construction Law
- Section of Environment, Energy and Resources
- Chester County Bar Association
- Green Building United