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詩 經 Shi Jing – The Book of Odes
The oldest collection of Chinese poetry, more than three hundred songs, odes and hymns. Tr. Legge (en) and Granet (fr, incomplete).
論 語 Lun Yu – The Analects of Confucius
The Master discusses with his disciples and unveil his preoccupations with society. Tr. Legge (en), Lau (en) and Couvreur (fr).
大 學 Daxue – The Great Learning
Confucean thought summarized for the Prince. Tr. Legge (en), Pauthier (fr), Bog (fr).
中 庸 Zhongyong – The Doctrine of the Mean
Confucius' grandson comments about the Way and human nature. Tr. Legge (en)
三 字 經 San Zi Jing – The Three-Character Classic
A textbook helpfull to start learning Classic Chinese. Tr. Giles (en) and Deverge (fr).
易 經 Yi Jing – I Ching, the Book of Changes
This famous system of 64 hexagrams plus their commentaries and transformations is at the root of Chinese thought. Tr. Wilhelm (en, fr).
道 德 經 Dao De Jing – The Way and Its Power
The naturalist, individualist and politic doctrine of Lao-tse exhibited in 81 poetic and obscure texts. Tr. Waley (en), Lau (en), Julien (fr) and Wilhelm (de).
An anthology of 320 poems. Discover Chinese poetry in its golden age and some of the greatest Chinese poets. Tr. by Bynner (en).
孫 子 兵 法 Sun Zi – The Art of War
Chinese strategy explained : know yourself and the ennemy, use deception, spies, and "win with ease". Tr. Giles (en, annotated) and Amiot (fr).
三 十 六 計 36 Ji – Thirty-Six Strategies
A recently uncovered notebook of 36 proverbs commented as military tactics that helps dealing with conflicts. Tr. Verstappen (en), Doc Mac Jr (fr).
Of [our] admirable, amiable, sovereign, / Most illustrious is the excellent virtue. / He orders rightly the people, [...] Cf. Shijing 249
The Master said, "If some years were added to my life, I would give fifty to the study of the Yî, and then I might come [...] Cf. Lunyu 167
Kuan / Contemplation (View) / The wind blows over the earth: The image of CONTEMPLATION. Thus the kings of old visited [...] Cf. Yijing 20
Banish wisdom, discard knowledge, / And the people will be benefited a hundredfold. / Banish human kindness, discard [...] Cf. Daodejing 19
To find you, moved beyond the city, / A wide path led me, by mulberry and hemp, / To a new-set hedge of [...] Cf. Tangshi 169
If you are situated at a great distance from the enemy, and the strength of the two armies is equal, it is not easy to [...] Cf. Sunzi 161
In these pages it's possible to read the Analects of Confucius (Lunyu), The Way and its Power (Daode Jing) attributed to Lao-tse and some other wisdom or poetry texts in Chinese with English and French translations. Any Chinese characters are linked to dictionaries. Your browser must display Chinese.
Why read Confucius, Lao-tse or the Book of Changes? Well, these Chinese classics have had a major influence on the oldest civilization still in existence on the face of this planet; that should be enough. If not, please consider that China, mostly as a distant mirror where hopes and fears are reflected, has exercised a profound impact on the thinking patterns of Western civilisations, and will. This article in the Routledge Encyclopedia of Philosophy explains things better.
Wengu – Chinese Classics – Chinese on/off – Français/English
The Book of Odes, The Analects, Great Learning, Doctrine of the Mean, Three-characters book, The Book of Changes, The Way and its Power, 300 Tang Poems, The Art of War, Thirty-Six Strategies
Welcome, help, notes, introduction, table.
Index – Contact – Top

subset: commoncrawl


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INTERNATIONAL YOGA DAY – Hear interviews with Former Sikh & Former Hindu!
INTERNATIONAL YOGA DAY – Hear my interviews with Former Sikh & Former Hindu, Nidhi Mehta. Like countless others, Nidhi was attacked by demonic spirits who had masqueraded as idols and gods, such as Shiva the Destroyer, Ganesha, Buddha and others, … Continue reading
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Is It Possible to Generate Income by betting?
Could you truly generate revenue by casino betting online? Naturally it is actually. But can you really lose funds by casino betting online? Oh yeah indeed, it definitely is. And what's more serious, it way more than likely that you'll drop cash simply because online gambling betting is gambling, ordinary and uncomplicated, and gambling is in reality a risky company by nature. you must generate income, nevertheless, you don't need to get swindled around the way, and therefore you don't wish to spend a lot of your own personal dollars. Thankfully, casino betting online is fairly safe and straightforward as soon as you best places to see and how to have relocating. You could be securely and safely and protected putting your Sports wagers online in particular minutes or so, and grows accumulating your earnings a short while following that. Below are a few recommendations:
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Judge temporarily blocks enforcement of Texas law banning contractors from boycotting Israel
Bahia Amawi, a contractor with the Pflugerville ISD, sued after she was told she must sign a pledge not toRead more
Bahia Amawi, a contractor with the Pflugerville ISD, sued after she was told she must sign a pledge not toRead more
Leaders at many of the state's top public universities have ordered across-the-board budget cuts for the next school year, evenRead more
Universities are required to investigate when a student is accused of raping another student. But if the accused transfers, hisRead more
A federal judge said that three professors suing the state to block campus carry didn't present any "concrete evidence toRead more
University of Texas System Chancellor Bill McRaven and Texas A&M University System Chancellor John Sharp earned $1.5 million and $1.3Read more
After years of challenging the University of Texas at Austin's use of affirmative action in federal court, Edward Blum willRead more
Ruth Simmons, the longtime president of Brown University, has been named interim president of Prairie View A&M University. Source:Read more
Prairie View A&M University President George Wright is stepping down after 14 years. He says he will return to theRead more
"We are a different university than we were one, two, three, five years ago," says Baylor President Linda Livingstone, who is aimingRead more
The austere state budget currently awaiting Republican Gov. Greg Abbott's signature includes a 10 percent funding hike for Texas' main methodRead more


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Monday, June 24, 2019 - 16:48
On Wednesday, Greenfields pupils in Key Stage 2 took part in health...
Monday, June 10, 2019 - 17:28
Year 6 this term are focussing on American history for their main...
- Tuesday, May 7, 2019 - 16:26On Friday 26th April, Year 5 enjoyed showcasing their A Midsummer Night's Dream opera at Nevill Holt theatre alongside other DRET Primary Schools. They did the school proud as they sang fantastically
- Monday, April 29, 2019 - 17:13On Thursday afternoon, the Year 3 and 4 Hockey team went to Bishop Stopford School and took part in a district tournament. They played a total of 5 pool games and came out in 1st place which meant
- Monday, April 29, 2019 - 17:12Year Two have had a super fun-filled week last week! They began their week with a WOW day on Tuesday, getting into the role of the Romans. The children spent the day learning about life as a Roman
- Monday, April 29, 2019 - 17:06To kick off their new term's topic, Stone Age, Dragonflies and Busy Bees have been engaging in a variety of Stone Age themed activities. In Forest School they were introduced to their new story, Cave
- Monday, April 29, 2019 - 17:02Last Tuesday, all children who have behaved impeccably this term had a really fun, Easter themed reward. They entered the playground to find a selection of clues, leading them to a surprise. The
- Friday, April 26, 2019 - 18:00On Thursday 4th April, 37 very excited Year 3 and 4 children headed over to Irthlingborough for their Rock UK residential. For some of the children it was quite a nerve-racking experience as this was
- Friday, April 26, 2019 - 17:48The last week of last term was Healthy Eating Week at Greenfields and at every other DRET Primary School. Each class were getting up to a variety of fun activities to help develop their understanding
- Monday, April 1, 2019 - 16:34Two new Parent Governors have recently been appointed to join the Greenfields Governing Body. Read below all about them and be sure to say hello to them if you see them around school. Gemma Lovegrove
- Monday, April 1, 2019 - 16:26On Tuesday, the Greenfields Netball and Football teams went to Malcolm Arnold Academy to take part in the DRET Primary Cup. Both teams played pool matches in the morning; the netball team came 2nd in
- Monday, April 1, 2019 - 16:22On Monday 25th March, a musical group of Year Five children travelled to Lodge Park Academy and performed a stunning song and dance as part of their Shakespeare Opera project to over a hundred


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Zip Code 01050, United States - Map
Huntington, Massachusetts
Huntington is a town in Hampshire County, Massachusetts, United States. The population was 2,180 at the time of the 2010 census. It is part of the Springfield, Massachusetts Metropolitan Statistical Area. Wikipedia.org
|Detailed Information
|City:Huntington, Massachusetts
|01050 Area:38.3 mi²
|Timezone:Eastern Daylight Time
|Local Time:Wednesday 5:28 PM
|Lat & Lng:42.2757° / -72.86328°
|Area Codes413
|Related Zip Codes:01036, 01053, 01054, 01056, 01057, 01059
Business Data for 01050
Businesses in 01050 - Huntington, Massachusetts
Education in 01050 - Huntington, Massachusetts
Huntington Dance Center
4.5 · Open Now
6 Main St, Huntington, MA 01050 · Huntington, Massachusetts
Gateway Regional School District
12 Littleville Rd, Huntington, MA 01050 · Huntington, Massachusetts
See more Education in 01050
Littleville Elementary School
4 Littleville Rd, Huntington, MA 01050, USA · Huntington, Massachusetts
Stats and Demographics for 01050
|Households in 01050:1,049
|People per Household:2.69
|Average House Value:$116,500
|Income per Household:$49,336
|Census Data:unitedstateszipcodes.org/01050/
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Mechanical Contractors in North Pole, AK
YP - The Real Yellow PagesSM - helps you find the right local businesses to meet your specific needs. Search results are sorted by a combination of factors to give you a set of choices in response to your search criteria. These factors are similar to those you might use to determine which business to select from a local Yellow Pages directory, including proximity to where you are searching, expertise in the specific services or products you need, and comprehensive business information to help evaluate a business's suitability for you. "Preferred" listings, or those with featured website buttons, indicate YP advertisers who directly provide information about their businesses to help consumers make more informed buying decisions. YP advertisers receive higher placement in the default ordering of search results and may appear in sponsored listings on the top, side, or bottom of the search results page.
1. Accurate Mechanical Contractors Inc.
Serving the North Pole Area
From Business: *Commercial - Industrial - Institutional
3. Arctic Plumbing and Heating
2135 Richardson Hwy Ste 2North Pole, AK 99705
From Business: Arctic Plumbing and Heating can perform the following with skilled and professional technicians : Boiler and Heating system installs or replacements, Water Heater…
4. Slayden Plumbing & Heating Sevice Department
1998 Richardson HwyNorth Pole, AK 99705
From Business: Founded in MAY of 1979. Slayden Plumbing & Heating Inc. Is engaged in the mechanical contracting business in the state of Alaska. Incorporated in the state of Ala…
6. Arctic Mechanical
231 Haines AveFairbanks, AK 99701
7. TCI Construction Company, Inc.
3680 Lathrop StFairbanks, AK 99701
From Business: ,
8. Western Mechanical Inc
2225 Van Horn RdFairbanks, AK 99701
From Business: About Since its inception in 1958, Western Mechanical Incorporated ( WMI ) has built a reputation as the best mechanical contracting company in Alaska. WMI employ…
10. Fast Alaska Heating Sales
399 Farmers Loop RdFairbanks, AK 99712
12. Central Mechanical Inc
1301 Well StFairbanks, AK 99701
13. Mechanical Contractors Of Fairbanks
1840 2nd AveFairbanks, AK 99701
14. American Mechanical
3203 Peger RdFairbanks, AK 99709
15. Superior Mechanical Inc
3284 Jefferson DrFairbanks, AK 99709
17. Paragon Plumbing & Heating
3400 Macarthur StFairbanks, AK 99701
18. Aaron Plumbing & Heating
Po Box 74413Fairbanks, AK 99707
From Business: Since 1982, Aaron Plumbing and Heating Company has been a mechanical contractor, installing plumbing, heating and air conditioning systems throughout the State of…
19. Complete Service Company
818 26th AveFairbanks, AK 99701
21. Superior Mechanical Inc
PO Box 82409Fairbanks, AK 99708
22. Complete Service Co Inc
129 Minnie StFairbanks, AK 99701
23. Aaron Plumbing & Heating
2143 Standard AveFairbanks, AK 99701
25. Alaska Mechanical Inc
5250 Airport Industrial RdFairbanks, AK 99709
26. J&J Mechanical Inc.
Fairbanks, AK 99709
From Business: J & J Mechanical is a locally owned and operated plumbing and heating contractor in the Fairbanks and North Pole area. We are fully licensed, bonded and insured a…
We found26results


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A popular homecare business for sale in Hereford, Hertfordshire. Established for nearly 10 years, the business offers a full set up including serviced offices, a team of office staff coordinating 30 c... More details »
Home improvement/retail franchise, supplying the world's finest plantation shutters to homes and businesses.
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A successful and established flooring business based in Golden Valley central for key market towns with very little competition and great catchment.
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HEREFORDSHIRE Renowned Herefordshire Gastro Pub Open Plan Character Bar & Dining Facilities (50) Excellent Catering Kitchen Gardens & Car Parking Separate Two Bedroom House Available
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Join a fantastic, fun and affordable five-star business opportunity in the leisure & entertainment industry.
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Main Road Substantial Free House. Over 6,600 square feet Elegant Grade II listed building
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Well Known and Successful Cafe/Restaurant Open plan split level dining area for 36
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Hereford city centre - historic real ale public house on doorstep of cathedral busy and historic city centre location historic thoroughfare leading to city's cathedral
well appointed and open plan tr... More details »
In a Charming Herefordshire Village
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Annual Sales £240,663
Trade Split ... More details »
Time For You is the UK's premier domestic cleaning company.
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Super fun lifestyle opportunity offering extensive & varied novelty range from extremely well fitted listed character parade showroom premises with high volume of year-round regular & passing trade in... More details »
Hereford - city riverside restaurant/take away Ground floor take away/restaurant. Large catering kitchen. Extensive lower ground floor storage area (suit conversion). Five/six bedroom owners accommod... More details »
An innovative windscreen repair service that provides the opportunity to be your own boss and develop a highly lucrative mobile business.
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HEREFORDSHIRE - EDGE OF CITY LANDMARK PUB Located in strategic position on new bypass. Two bars. Three bedroom owners accommodation. Car parking. Currently closed. EPC rating E.... More details »
Sale of City Centre High Trading Coffee Shop as an investment subject to lease agreement
For Sale after 60 years in same family's handsGround & First Floor Cafe/Dining Areas (150+)
Three Catering Ki... More details »
The largest network of accountants in the UK, providing bookkeeping, payroll, tax and accountancy services to small businesses.
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Hereford - city riverside restaurant/take away Ground floor take away/restaurant. Large catering kitchen. Extensive lower ground floor storage area (suit conversion). Five/six bedroom owners accommoda... More details »
Business Partnership are delighted to offer this exceptional, mainly takeaway and delivery, pizza fast food outlet, which has only been offered to the market due to pending retirement.
The business w... More details »
Very long established & highly regarded business offering premium quality produce from superbly fitted unit in historic cathedral city centre indoor market hall with high volume of year-round regular ... More details »
Autosmart International is the UK's largest manufacturer of professional vehicle cleaning products to the trade. Autosmart has been helping franchisees to make a success of their businesses for nearly... More details »
Outstanding opportunity to acquire young & still-expanding restaurant operating from impressive 80-cover air-conditioned character parade premises fitted to superb Tripadvisor highly rated specs with ... More details »
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(EDGAR Online via COMTEX) -- ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
The following discussion and analysis summarizes the significant factors affecting our results of operations, financial condition and liquidity position for the three and nine months ended September 30, 2018 and 2017, and should be read in conjunction with our unaudited condensed consolidated financial statements and related notes included elsewhere in this filing.
This report contains forward-looking statements. These statements relate to future events or to our future financial performance and involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.
Factors that might affect our forward-looking statements include, among other things:
? overall economic and business conditions;
? U.S. and China's foreign policies;
? the demand for our products and services;
? competitive factors in the market in which we compete;
? the emergence of new technologies which compete with our product and service offerings;
? our cash position and cash burn rate;
? other capital market conditions, including availability of funding sources;
? the strength of our intellectual property portfolio; and
? changes in government regulations in China and in the U.S. related to our industries.
In some cases, you can identify forward-looking statements by terms such as "may", "will", "should", "could", "would", "expects", "plans", "anticipates", "believes", "estimates", "projects", "predicts", "potential" and similar expressions. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. We discuss many of these risks in greater detail under the heading "Risk Factors" included in other reports we file with the Securities and Exchange Commission. Also, these forward-looking statements represent our estimates and assumptions only as of the date of the document containing the applicable statement.
Unless required by law, we undertake no obligation to update or revise any forward-looking statements to reflect new information or future events or developments. Thus, you should not assume that our silence over time means that actual events are bearing out as expressed or implied in such forward-looking statements.
The "Company", "CBMG", "we", "us", "our" and similar terms refer to Cellular Biomedicine Group, Inc. (a Delaware corporation) as a combined entity including each of its subsidiaries and controlled companies, unless the context otherwise requires.
Recent Developments
On January 3, 2017, we announced the signing of a ten-year lease of an 113,038-square foot building located in the "Pharma Valley" in Shanghai Zhangjiang High-Tech Park. The new facility designed and built to GMP standards has approximately 40,000 square feet dedicated to advanced cell manufacturing.
On January 9, 2017, we announced the commencement of patient enrollment in China for our CALL-1 ("CAR-T against Acute Lymphoblastic Leukemia") Phase I clinical trial of CD19 CAR-T therapy utilizing our optimized proprietary C-CAR011 construct for the treatment of patients with relapsed or refractory (r/r) CD19+ B-cell ALL. We have been enrolling patients and working with the China Center for Drug Evaluation ("CDE") of the NMPA to obtain approval of the Company's IND application.
On May 15, 2017, we announced the addition of a new independent Phase I clinical trial of the Company's ongoing CARD-1 study in patients with chemorefractory or refractory B cell Non-Hodgkin Lymphoma ("NHL"). The Company and Shanghai Tongji Hospital are conducting a single arm, non-randomized study to evaluate the safety and efficacy of C-CAR011 (Anti-CD19 single-chain variable fragment (scFv) (41BB-CD3zeta)) therapy in relapsed or refractory B cell NHL patients. We have been enrolling patients and working with CDE to obtain approval of the Company's IND application.
On June 1, 2017, we announced that our Board of Directors approved a stock repurchase program (the "2017 Share Repurchase Program") granting the Company authority to repurchase up to $10 million in common shares through open market purchases pursuant to a plan adopted in accordance with Rule 10b5-1 and Rule 10b-18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"). The program contemplated repurchases of shares of the Company's common stock in the open market in accordance with all applicable securities laws and regulations. From June 2017 to June 2018 the Company repurchased a total of 560,768 shares at a total price of $6,513,993, or an average of $11.62 per share.
On June 20, 2017, we announced the establishment of an External Advisory Board and the appointment of Michael A. Caligiuri, MD, then President of the AACR and director of The Ohio State University Comprehensive Cancer Center and CEO of the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute in Columbus, Ohio, as Chair of the External Advisory Board to bring together experts from diverse disciplines to provide knowledge and insight to help CBMG fulfill its mission and build a network for development opportunities. Dr. Caligiuri is president of City of Hope National Medical Center and physician-in-chief.
On June 26, 2017, we announced the appointment of Dr. Xia Meng as Chief Operating Officer for the Company. On February 6, 2018, driven by the Company's strategic move to expand its business operations in early diagnosis and cancer intervention, Meng Xia transitioned from the role of Chief Operating Officer to Head of the Early Diagnosis & Intervention for the Company.
On November 4, 2017, we announced the grand opening of our Zhangjiang facility. On the same day, we announced the signing of a strategic partnership with Thermo Fisher Scientific (China) Ltd. to build a joint Cell Therapy Technology Innovation and Application Center at CBMG's newly opened Shanghai Zhangjiang facility.
On December 28, 2017, we announced the closing of two private placement transactions pursuant to which we sold an aggregate of 1,208,333 shares of the Company's common stock to select key executives and private investors at $12.00 per share, for total aggregate gross proceeds of approximately $14.5 million.
On January 30, 2018 and February 5, 2018, we entered into securities purchase agreements with certain investors pursuant to which the Company agreed to sell, and the investors agreed to purchase from the Company, an aggregate of 1,719,324 shares (the "February 2018 Private Placement") of the Company's common stock, par value $0.001 per share, at $17.80 per share, for total gross proceeds of approximately $30.6 million. The transaction closed on February 5, 2018. Pursuant to the purchase agreement, the Investors have the right to nominate one director to the board of directors of the Company to stand for election at the 2018 Annual Meeting of Stockholders. Effective as of the closing of the February 2018 Private Placement, Bosun S. Hau was appointed as a non-executive Class III director of the Company and his appointment was subsequent ratified by the shareholders during the Annual Shareholders Meeting on April 27, 2018,
On February 15, 2018, we obtained a 36-month exclusive option with Augusta University to negotiate a royalty-bearing, exclusive license to the patent rights owned by the Augusta University relating to an invention to identify novel alpha fetoprotein ("AFP") specific TCR for a hepatocellular carcinoma ("HCC") immunotherapy. The Company is evaluating the feasibility and opportunities of this novel alpha fetoprotein TCR to redirect T Cells for the HCC indication. We are evaluating the efficacy and specificity of the AFP TCR to identity the most appropriate candidate for first time in human ("FTIH") study. In addition, human CD8+ T cells will be redirected with the AFP TCRs and their anti-tumor activity will be evaluated by in vitro cytokine release assay and cytotoxicity assay. Concurrently, potential on/off-target toxicity including allo-reactivity will also be evaluated and the best candidate TCRs for clinical use will be further tested in humanized mouse models. We plan to exercise our exclusive right to license the technology from Augusta University if and when the FTIH proof of mechanism study shows promising clinical efficacy signal and manageable safety profile.
On March 16, 2018, we issued a press release announcing the presentation of the Allojoin(TM) Phase I 48-week data in China, as well as the termination of the Company's U.S. Allojoin(TM) program with CIRM to focus the clinical development in China. Prior to termination, the Company had received $1.2 million of the potential $2.29 million available under the CIRM grant.
On April 18, 2018 and April 21, 2018, the NMPA CDE posted on its website acceptance of the IND application for CAR-T cancer therapies in treating patients with NHL and ALL submitted by two of the wholly-owned subsidiaries of the Company, respectively. Thus far, a total of three Chinese companies that submitted their IND application ahead of the Company have received approval of their IND application for CAR-T cancer therapies.
On June 22, 2018, the Company announced the grand opening of its new research and development center in Gaithersburg, Maryland.
On September 25, 2018, the Company, together with certain of its subsidiaries and controlled entities, entered into a License and Collaboration Agreement (the "Collaboration Agreement") with Novartis pursuant to which the Company will manufacture and supply Novartis the T CAR-T cell therapy Kymriah(R) (tisagenlecleucel) (the "Product") in China. The Company also granted Novartis a world-wide license certain of its intellectual property and technology, including intellectual property and technology related to the Product. Such license is exclusive with respect to the development, manufacture and commercialization of the Product and non-exclusive with respect to the development, manufacture and commercialization of other products.
Also, on September 25, 2018, we entered into a Share Purchase Agreement with Novartis pursuant to which the Company agreed to sell, and Novartis agreed to purchase from the Company, an aggregate of 1,458,257 shares of the Company's common stock, at a purchase price of $27.43 per share, which was the equivalent of 130% of the volume-weighted average price of the Common Stock for the prior 20 consecutive trading days, for total gross proceeds of approximately $40 million (the "Private Placement"). In connection with the Private Placement, the Company filed a Form S-3 with the SEC on October 10, 2018 to satisfy the registration requirement. The SEC declared the registration effective on October 22 and the Company filed the Private Placement Prospectus on October 23, 2018.
On October 2, 2018, we entered into entered into a non-exclusive license agreement with The U.S. Department of Health and Human Services, as represented by National Cancer Institute, an Institute or Center (the "IC") of the National Institutes of Health, pursuant to which the Company was granted rights to the worldwide development, manufacture and commercialization of autologous, tumor-reactive lymphocyte adoptive cell therapy products, isolated from tumor infiltrating lymphocytes as claimed in the IC licensed patent rights, for the treatment of non-small cell lung, stomach, esophagus, colorectal, and head and neck cancer(s) in humans.
On October 10, 2018, we announced that we commenced a stock repurchase program (the "2018 Share Repurchase Program") granting the Company authority to purchase up to $8.48 million in common shares through open market purchases pursuant to a plan adopted in accordance with Rule 10b5-1 and Rule 10b-18 of the Exchange Act. The program contemplated repurchases of shares of the Company's common stock in the open market in accordance with all applicable securities laws and regulations. It is contemplated that total shares to be repurchased under the 2017 and 2018 Share Repurchase Programs shall not exceed $15 million in the aggregate.
On October 29, 2018, after reassessing the return of investment to develop GVAX for cancer therapies in the current competitive market the Company notified USF and Moffitt to terminate its GVAX license agreements.
On November 2, 2018, we relocated our principal executive offices from Cupertino, California to New York, New York.
In the next 12 months, we aim to accomplish the following, though there can be no assurances that we will be able to accomplish any of these goals:
Corporate History
Please refer to Note 1 of unaudited condensed consolidated financial statements for the corporate history.
The biopharmaceutical business was founded in 2009 by a team of seasoned Chinese-American executives, scientists and doctors. In 2010, we established a facility designed and built to China's Good Manufature Practice (GMP) standards in Wuxi, China and in 2012 we established a U.S. Food and Drug Administration (FDA) GMP standard protocol-compliant manufacturing facility in Shanghai. In October 2015, we opened a facility designed and built to GMP standards in Beijing. In November 2017, we opened our Zhangjiang facility in Shanghai, of which 40,000 square feet was designed and built to GMP standards and dedicated to advanced cell manufacturing. Our focus has been to serve the rapidly growing health care market in China by marketing and commercializing immune cell and stem cell therapeutics, related tools and products from our patent-protected homegrown and acquired cell technology, as well as by utilizing in-licensed and other acquired intellectual properties.
Our current treatment focal points are KOA and cancer and we are evaluating companion diagnostics that can benefit personalized cancer treatment.
Cancer. We are focusing our clinical development efforts on CD20-, CD22- and B-cell maturation antigen (BCMA)-specific CAR-T therapies, T-cell receptor (TCR) and tumor infiltrating lymphocyte (TIL) technologies. With the execution of the Novartis Collaboration Agreement we have prioritized our efforts on working with Novartis to bring Kymriah to patients in China as soon as practicable. In view of our collaboration with Novartis, we will no longer pursue our own ALL and DLBCL BLA submission with the National Medical Products Administration (NMPA). On the research and development side we will endeavor to bring our CD22 HCL and CD19 CAR-T relapsing ALL, CD 20 for CD19 CAR-T Relapsing NHL, BCMA in Multiple Myeloma (MM), NKG2D in acute myeloid leukemia (AML), AFP TCR-T in Hepatocellular carcinoma (HCC) and neoantigen reactive TIL on solid tumors, respectively, in first in human trial as soon as possible. We plan to continue to leverage our quality system and our strong scientific expertise to develop a platform as preferred parties for international pharmaceutical companies to co-develop cell therapies with the Company in China by implementing our quality strategies and leveraging the experience and expertise of our strong scientific team in the U.S and in China.
KOA. In 2013, we completed a Phase I/IIa clinical study, in China, for our KOA therapy named Re-Join(R). The trial tested the safety and efficacy of intra-articular injections of autologous haMPCs in order to reduce inflammation and repair damaged joint cartilage. The 6-month follow-up clinical data showed Re-Join(R) therapy to be both safe and effective.
In Q2 of 2014, we completed patient enrollment for the Phase IIb clinical trial of Re-Join(R) for KOA. The multi-center study enrolled 53 patients to participate in a randomized, single blind trial. We published 48 weeks follow-up data of Phase I/IIa on December 5, 2014. The 48 week data indicated that patients have reported a decrease in pain and a significant improvement in mobility and flexibility, while the clinical data shows our Re-Join(R) regenerative medicine treatment to be safe. We announced the interim 24 week results for Re-Join(R) on March 25, 2015 and released positive Phase IIb 48 week follow-up data in January 2016, which shows the primary and secondary endpoints of Re-Join(R) therapy group having all improved significantly compared to their baseline, which has confirmed some of the Company's Phase I/IIa results. Our Re-Join(R) human adipose-derived mesenchymal progenitor cell (haMPC) therapy for KOA is an interventional therapy using proprietary process, culture and medium.
Our process is distinguishable from sole Stromal Vascular Fraction (SVF) therapy. The immunophenotype of our haMPCs exhibited multiple biomarkers such as CD29+, CD73+, CD90+, CD49d+, HLA-I+, HLA-DR-, Actin-, CD14-, CD34-, and CD45-. In contrast, SVF is merely a heterogeneous fraction including preadipocytes, endothelial cells, smooth muscle cells, pericytes, macrophages, fibroblasts, and adipose-derived stem cells.
In January 2016, we launched the Allogeneic KOA Phase I Trial in China to evaluate the safety and efficacy of AlloJoin(TM), an off-the shelf allogeneic adipose derived progenitor cell (haMPC) therapy for the treatment of KOA. On August 5, 2016 we completed patient treatment for the Allogeneic KOA Phase I trial, and on December 9, 2016 we announced interim 3-month safety data from the Allogenic KOA Phase I Trial in China. The interim analysis of the trial has preliminarily demonstrated a safety and tolerability profile of AlloJoin(TM) in the three doses tested, and no serious adverse events (SAE) have been observed. On March 16, 2018, we announced the positive 48-week Allojoin(TM) Phase I data in China, which demonstrated good safety and early efficacy for the prevention of cartilage deterioration. China has finalized its cell therapy policy in December, 2017. We plan to advance the KOA IND application for AlloJoin(TM) with NMPA in the near future.
The unique lines of adult adipose-derived progenitor cells and the immune cell therapies enable us to create multiple cell formulations in treating specific medical conditions and diseases. The quality management systems of CBMG Shanghai were issued a Certificate of ISO-9001:2015 in 2018 and to be updated to 9001:2015 in this year. (i)The cleanrooms in our new facility are ISO 14644 certified and in compliance with China's Good Manufacture Practice (GMP) requirement (2010 edition); (ii) the equipment in the new Shanghai facility has been calibrated and qualified, and the biological safety cabinets were also qualified. The quality management systems of CBMG Wuxi were certified as meeting the requirement of ISO-9001:2015, and the facility and equipment were also qualified.
Our proprietary processes and procedures include (i) banking of allogenic cellular product and intermediate product; (ii) manufacturing procedures of GMP-grade viral vectors; (iii) manufacturing procedures of GMP-grade cellular product; (iv) analytical testing to ensure the safety, identity, purity and potency of cellular product.
Recent Developments in Cancer Cell Therapy
According to the U.S. National Cancer Institute's 2013 cancer topics research update on CAR-T-Cells, excitement is growing for immunotherapy-therapies that harness the power of a patient's immune system to combat their disease, or what some in the research community are calling the "fifth pillar" of cancer treatment.
One approach to immunotherapy involves engineering patients' own immune cells to recognize and attack their tumors. This approach is called adoptive cell transfer (ACT). ACT's building blocks are T cells, a type of immune cell collected from the patient's own blood. One of the well-established ACT approaches is CAR-T cancer therapy. After collection, the T cells are genetically engineered to produce special receptors on their surface called chimeric antigen receptors (CARs). CARs are proteins that allow the T cells to recognize a specific protein (antigen) on tumor cells. These engineered CAR-T cells are then grown until they number in the billions. The expanded population of CAR-T cells is then infused into the patient. After the infusion, if all goes as planned, the T cells multiply in the patient's body and, with guidance from their engineered receptor, recognize and kill cancer cells that harbor the antigen on their surfaces. This process builds on a similar form of ACT pioneered from NCI's Surgery Branch for patients with advanced melanoma. According to www.cancer.gov/.../research-updates/2013/CAR-T-Cells, in 2013 NCI's Pediatric Oncology Branch commented that the CAR-T cells are much more potent than anything they can achieve with other immune-based treatments being studied. Although investigators working in this field caution that there is still much to learn about CAR T-cell therapy, the early results from trials like these have generated considerable optimism.
CAR-T cell therapies, such as anti-CD19 CAR-T and anti-BCMA CAR-T, have been tested in several hematological indications on patients that are refractory/relapsing to chemotherapy, and many of them have relapsed after stem cell transplantation. All of these patients had very limited treatment option prior to CAR-T therapy. CAR-T has shown encouraging clinical efficacy in many of these patients, and some of them have durable clinical response for years. However, some adverse effects, such as cytokine release syndrome (CRS) and neurological toxicity, have been observed in patients treated with CAR-T cells. For example, in July 2016, Juno Therapeutics, Inc. reported the death of patients enrolled in the U.S. Phase II clinical trial of JCAR015 (anti-CD19 CAR-T) for the treatment of relapsed or refractory B cell acute lymphoblastic leukemia (B-ALL). The US FDA put the trial on hold and lifted the hold within a week after Juno provided satisfactory explanation and solution. Juno attributed the cause of patient deaths to the use of Fludarabine preconditioning and they switched to use only cyclophosphamide pre-conditioning in subsequent enrollment.
In August 2017, the U.S. FDA approved Novartis' Kymriah (tisagenlecleucel), a CD19-targeted CAR-T therapy, for the treatment of patients up to 25 years old for relapsed or refractory (r/r) acute lymphoblastic leukemia (ALL), the most common cancer in children. Current treatments show a rate of 80% remission using intensive chemotherapy. However, there are almost no conventional treatments to help patients who have relapsed or are refractory to traditional treatment. Kymriah has shown results of complete and long lasting remission, and was the first FDA-approved CAR-T therapy. In October 2017, the U.S. FDA approved Kite Pharmaceuticals' (Gilead) CAR-T therapy for diffuse large B-cell lymphoma (DLBCL), the most common type of NHL in adults. The initial results of axicabtagene ciloleucel (Yescarta), the prognosis of high-grade chemo refractory NHL is dismal with a medium survival time of a few weeks. Yescarta is a therapy for patients who have not responded to or who have relapsed after at least two other kinds of treatment.
In May 2018, the FDA approved Novartis' Kymriah for intravenous infusion for its second indication - the treatment of adult patients with relapsed or refractory (r/r) large B-cell lymphoma after two or more lines of systemic therapy including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, high grade B-cell lymphoma and DLBCL arising from follicular lymphoma. Kymriah is now the only CAR-T cell therapy to receive FDA approval for two distinct indications in non-Hodgkin lymphoma (NHL) and B-cell ALL. On September 25, 2018, we entered into the Collaboration Agreement with Novartis to manufacture and supply Kymriah to Novartis in China.
Besides anti-CD19 CAR-T, anti-BCMA CAR-T has shown promising clinical efficacy in treatment of multiple myeloma. For example, bb2121, a CAR-T therapy targeting BCMA, has been developed by Bluebird bio, Inc. and Celgene for previously treated patients with multiple myeloma. Based on preliminary clinical data from the ongoing phase 1 study CRB-401, bb2121 has been granted Breakthrough Therapy Designation by the U.S. FDA and PRIME eligibility by the European Medicines Agency (EMA) in November 2017. We plan to initiate our anti-BCMA CAR-T investigator initiated trial in late 2018.
Recent progress in Universal Chimeric Antigen Receptor (UCAR) T-cells showed benefits such as ease of use, availability and the drug pricing challenge. Currently, most therapeutic UCAR products have been developed with gene editing platforms such as CRISPR or TALEN. For example, UCART19 is an allogeneic CAR T-cell product candidate developed by Cellectis for treatment of CD19-expressing hematological malignancies. UCART19 Phase I clinical trials started in adult and pediatric patients in Europe in June 2016 and in the U.S. in 2017. The use of UCAR may has the potential to overcome the limitation of the current autologous approach by providing an allogeneic, frozen, "off-the-shelf" T cell product for cancer treatment.
While CAR-T cell therapy has been proven successful in treatment of several hematological malignancies, other cell therapy approaches, including Tumor Infiltrating Lymphocytes (TIL) and T Cell Receptor engineered T cells (TCR-Ts) are being developed to treat solid tumors. For example, Iovance Biotherapeutics is focused on the development of autologous tumor-directed TILs for treatments of patients with various solid tumor indications. Iovance is conducting several Phase 2 clinical trials to assess the efficacy and safety of autologous TIL for treatment of patients with Metastatic Melanoma, Squamous Cell Carcinoma of the Head and Neck, Non-Small Cell Lung Cancer (NSCLC) and Cervical Cancer in the US and Europe.
Adaptimmune is partnering with GlaxoSmithKline to develop TCR-T therapy targeting the NY-ESO-1 peptide, which is present across multiple cancer types. . . .
Nov 06, 2018
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Jews' ears Juice? It is surely not Kosher!
Source: URL
How desperate one must be in order to drink from a can with the inscription "Quality Juice made of Jews' ears".
In China nobody makes a big deal of it: in the meantime the drinking has turned into a cult.
We are used to hear antisemitic propaganda sometimes. The above mentioned drink is called in fact black mushroom.
The ingredients are actually not so disgusting: water, black mushroom, crab apple, dates, honey, lemon juice and stabilizers. But in order to market it around the world there is a need to embellish the name a little bit.
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Norway's authorities is proposing to increase the realm that can be provided for oil and fuel exploration within the 2019 licensing spherical of acreage in mature areas, Petroleum and Vitality Minister Kjell-Børge Freiberg mentioned on Thursday.
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TBA @ B10 Live
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11 pm @ O! Garden
8pm @ Shenzhen Poly Theatre
22:00 @ Oil Club
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8.45pm-late @ Baia Restaurant Bar Grill
@ Hou Live
2019-04-01 @ Kempinski Hotel
12.30pm @ Jilou Space
@ Residence G Shenzhen
8pm @ Mountain View Theater
10pm @ Barber Shop
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5.30-9.30pm @ Market Cafe at Hyatt Regency Shenzhen Airport
7-10pm @ Mambo
10am-10pm @ MixC World (Shenzhen Bay)
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Betrayal: Detail
- Published/Created:
- 1390
- Date Depicted:
- 1975
- Notes:
- By the Master of the Accademia Crucifix (?). Short and long tunics with a variety of overgarments. The cape of the central figure is beautifully decorated in an allover diaper pattern.
- Abstract:
- The garde-corps is the first overcoat. A garment of mass and dignity, it is long and full throughout the body. Full, capelike sleeves are attached to the shoulders with gauging or cartridge pleating. At the elbow position there is a slash for the arms. A separate cowl collar or hood is put on over the head. When the gardecorps is lined in fur (usually ermine), it is referred to as the pelisson. Older mantles and capes remain, often lined in contrasting colors. Cape fastenings vary from side to center front.
- Topics:
- Costume -- Europe -- History -- (LC)
Painting -- Italy -- 14th century -- (YVRC)
- Period/Style:
- Gothic (Medieval)
- Culture:
- Italian
- Accession Number:
- 4389-013
- Genre:
- costume (mode of fashion) (AAT)
paintings (AAT)
- Format:
- Image
- Content Type:
- Clothing & Accessories
Paintings & Drawings
- Rights:
- The use of this image may be subject to the copyright law of the United States (Title 17, United States Code) or to site license or other rights management terms and conditions. The person using the image is liable for any infringement.
- Access Restrictions:
- Yale Community Only
- Source Creator:
- Button, Jeanne and Sbarge, Stephen
- Source Title:
- History of Costume, In Slides, Notes and Commentaries: Volume 2
- Source Created:
- New York, NY
Theatre Arts Slide Presentations
- Call Number:
- Orbis Barcode:
- 39002051938489
- Yale Collection:
- Visual Resources Collection
- Digital Collection:
- Visual Resources Collection
- Original Repository:
- Florence, Italy: Galleria degli Uffizi
- 10596321
- digcoll:1805549


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What are the best James Larkin quotes? Read the most famous quotes by James Larkin. Top 10 James Larkin images and Top 10 James Larkin quotes. James Larkin quotations on ireland, fight, workers, right, means are those that make this activist famous.Go to table of contents
James Larkin is famous Irish activist with many wise quotes. Share the best James Larkin quotations of all times with your friends and family.
The men whose manhood you have broken will loathe you, and will always be brooding and scheming to strike a fresh blow.
We make mistakes, we have our faults, and God knows some of us have more than our share, but when danger threatens and duty calls, we go smiling to our own funeral.
The question of religion was a matter for each individual's conscience, and in a great many cases was the outcome of birth or residence in a certain geographical area.
Intolerance has been the curse of our country.
We are now on the threshold of a newer movement, with a newer hope and a new inspiration.
By God's help, and the intelligent use of their own strong right arms they could accomplish great things.
No, men and women of the Irish race, we shall not fight for England. We shall fight for the destruction of the British Empire and the construction of an Irish republic.
Those who want to divide the workers have resorted to the foulest methods.
There must be freedom for all to live, to think, to worship, no book, no avenue must be closed.
I have raised the morals and sobriety of the people.
The souls you have got cast upon the screen of publicity appear like the horrid and writhing creatures enlarged from the insect world, and revealed to us by the cinematograph.
The employers cannot carry on industry nor accumulate profits if they have not got the good will of the workers or their acquiescence in carrying on such industry.
Comrades - We are living in momentous times.
The best thanks we could offer those who went before and raised the Irish working class from their knees was to press forward with determination and enthusiasm towards the ultimate goal of their efforts, a Co-operative Commonwealth for Ireland.
The fate of you, the aristocracy of industry, will be as the fate of the aristocracy of land if you do not show that you have some humanity still among you.
Claiming for ourselves liberty of conscience, liberty to worship, we shall see to it that every other individual enjoys the same right.
I am, of course, aware that the ultimate solution is the ownership and control of the means of life by the whole of the people; but we are not at that stage of development as yet.
We are beaten, we will make no bones about it; but we are not too badly beaten still to fight.
For years and years I have done the work I was born for.
You may succeed in your policy and ensure your own damnation, by your victory.
Humanity abhors, above all things, a vacuum in itself, and your class will be cut off from humanity as the surgeon cuts the cancer and alien growth from the body.
It means that the men who hold the means of life control our lives, and, because we workingmen have tried to get some measure of justice, some measure of betterment, they deny the right of the human being to associate with his fellow.
I am careful about my conduct because I know this cause requires clean men.
I never stood in a public house bar and alcoholic drink never touched my lips.
I have tried to kill sectarianism, whether in Catholics or Protestants.
Russia is the only place where men and women can be free.
We shall not fight for the preservation of the enemy, which has laid waste with death and desolation the fields and hills of Ireland for 700 years.
A mutual arrangement, I repeat, is the only satisfactory medium whereby the present system can be carried on with any degree of satisfaction, and in such an arrangement the employers have more to gain than the workers.
The land of Ireland for the people of Ireland.
Man must be associated with his fellows.
Therefore it is essential that some means should be sought whereby the work of the nation may be carried on without constant yet at present necessary dislocation.
Stop at home. Arm for Ireland. Fight for Ireland and no other land.
What are the best James Larkin images quotes? Read and bookmark finest quotes from James Larkin, embed as messages on beautiful images. Those images have ireland quotes, fight quotes, workers quotes, right quotes, means quotes.
That were top sayings and James Larkin picture quotes. Access more quotations by James Larkin with images on Pinterest.Go to table of contents
Where is James Larkin from? James Larkin is Irish who said awesome wise words. A influential and well recognized activist all over the world. The following quotations and images represent the Irish nature embed in James Larkin's character.
What James Larkin was famous for? James Larkin is famous activist with many good quotes. Well-known and respected in Irish society for wise sayings. Browse a lot of James Larkin books and reference books with quotes from James Larkin on Amazon.
Which activist has the best quotes? Top quotes from famous activists like the following.
James Larkin is famous for his passion for ireland, fight, workers, right, means. Check out great quotations and affirmations.
That were all of the 32 James Larkin quotes. Maybe some questions are in your head.
How to save James Larkin quotations? Save every quote you like to your Bookmarks for further reference. We rank the quotes by the number of bookmarks each one has. By bookmarking a quotation you increase its position in Quotlr rankings. We use top quotes as affirmations in our daily quote iPhone app.
How do you quote James Larkin? You are free to cite every quote from James Larkin found on Quotlr. Hit the share button to get sharing options for Facebook, Twitter or direct link for email.
When was James Larkin birthday? James Larkin was born on 21 January 1876.
Who is James Larkin? Some facts about James Larkin from biography. James (Jim) Larkin (21 January 1876 – 30 January 1947) was an Irish trade union leader and socialist activist, born to Irish parents in Liverpool, England. He and his family later moved to a small cottage in Burren, southern County Down. Growing up in poverty, he received little formal education a... Read more about James Larkin on Wikipedia or watch videos with quotes from James Larkin on YouTube.
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The FIB 800-M uses Magnum ion column. This FIB is used for circuit edit (front and back side), defect and failure analysis, TEM lamella prep, nanofabrication, nanoprototyping and MEMS. Includes installation, operational training and 90day warranty.
This FEI FIB 800-M includes:
• Magnum ion column, 5–30kV
• Milling Power: 22nA beam current and 100 A/cm² current density
• CDEM for ions and electron images with 7nm image resolution
• Windows OS and FEI UI; TSS networking computer to make IT happy
• 5-axis motorized eucentric tilt stage
• Full coverage of 200mm diameter sample
• Chamber scope for real time observation
• Gas Injection System: Max 4 injectors; 2 included, chemistry of choice
• Vacuum System: column IGP, air cooled Turbo and mechanical PVP
Available Options Include:
• GIS chemistries
• Plasma Cleaner
• Infrared for backside editing
• Omniprobe for lift out
• Omniprobe for probing
• Dry pump to replace mechanical oil PVP