text:
Year of publication
- apoptosis (3)
- autophagy (3)
- cell biology (3)
- glioblastoma (2)
- human (2)
- mouse (2)
- ubiquitin (2)
- 3Cs technology (1)
- Autophagy (1)
- Manatee invariants reveal functional pathways in signaling networks (2017)
- Background: Signal transduction pathways are important cellular processes to maintain the cell's integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they form intertwined networks. Mathematical models aim to capture their regulatory logic and allow an unbiased analysis of robustness and vulnerability of the signaling network. Pathway detection is yet a challenge for the analysis of signaling networks in the field of systems biology. A rigorous mathematical formalism is lacking to identify all possible signal flows in a network model. Results: In this paper, we introduce the concept of Manatee invariants for the analysis of signal transduction networks. We present an algorithm for the characterization of the combinatorial diversity of signal flows, e.g., from signal reception to cellular response. We demonstrate the concept for a small model of the TNFR1-mediated NF- κB signaling pathway. Manatee invariants reveal all possible signal flows in the network. Further, we show the application of Manatee invariants for in silico knockout experiments. Here, we illustrate the biological relevance of the concept. Conclusions: The proposed mathematical framework reveals the entire variety of signal flows in models of signaling systems, including cyclic regulations. Thereby, Manatee invariants allow for the analysis of robustness and vulnerability of signaling networks. The application to further analyses such as for in silico knockout was shown. The new framework of Manatee invariants contributes to an advanced examination of signaling systems.
- In silico knockout studies of xenophagic capturing of salmonella (2016)
- The degradation of cytosol-invading pathogens by autophagy, a process known as xenophagy, is an important mechanism of the innate immune system. Inside the host, Salmonella Typhimurium invades epithelial cells and resides within a specialized intracellular compartment, the Salmonella-containing vacuole. A fraction of these bacteria does not persist inside the vacuole and enters the host cytosol. Salmonella Typhimurium that invades the host cytosol becomes a target of the autophagy machinery for degradation. The xenophagy pathway has recently been discovered, and the exact molecular processes are not entirely characterized. Complete kinetic data for each molecular process is not available, so far. We developed a mathematical model of the xenophagy pathway to investigate this key defense mechanism. In this paper, we present a Petri net model of Salmonella xenophagy in epithelial cells. The model is based on functional information derived from literature data. It comprises the molecular mechanism of galectin-8-dependent and ubiquitin-dependent autophagy, including regulatory processes, like nutrient-dependent regulation of autophagy and TBK1-dependent activation of the autophagy receptor, OPTN. To model the activation of TBK1, we proposed a new mechanism of TBK1 activation, suggesting a spatial and temporal regulation of this process. Using standard Petri net analysis techniques, we found basic functional modules, which describe different pathways of the autophagic capture of Salmonella and reflect the basic dynamics of the system. To verify the model, we performed in silico knockout experiments. We introduced a new concept of knockout analysis to systematically compute and visualize the results, using an in silico knockout matrix. The results of the in silico knockout analyses were consistent with published experimental results and provide a basis for future investigations of the Salmonella xenophagy pathway. Author Summary Salmonellae are Gram-negative bacteria, which cause the majority of foodborne diseases worldwide. Serovars of Salmonella cause a broad range of diseases, ranging from diarrhea to typhoid fever in a variety of hosts. In the year 2010, Salmonella Typhi caused 7.6 million foodborne diseases and 52 000 deaths, and Salmonella enterica was responsible for 78.7 million diseases and 59 000 deaths. After invasion of Salmonella into host epithelial cells, a small fraction of Salmonella escapes from a specialized intracellular compartment and replicates inside the host cytosol. Xenophagy is a host defense mechanism to protect the host cell from cytosolic pathogens. Understanding how Salmonella is recognized and targeted for xenophagy is an important subject of current research. To the best of our knowledge, no mathematical model has been presented so far, describing the process of Salmonella Typhimurium xenophagy. Here, we present a manually curated and mathematically verified theoretical model of Salmonella Typhimurium xenophagy in epithelial cells, which is consistent with the current state of knowledge. Our model reproduces literature data and postulates new hypotheses for future investigations.
- Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas (2016)
- Recently, the conserved intracellular digestion mechanism 'autophagy' has been considered to be involved in early tumorigenesis and its blockade proposed as an alternative treatment approach. However, there is an ongoing debate about whether blocking autophagy has positive or negative effects in tumor cells. Since there is only poor data about the clinico-pathological relevance of autophagy in gliomas in vivo, we first established a cell culture based platform for the in vivo detection of the autophago-lysosomal components. We then investigated key autophagosomal (LC3B, p62, BAG3, Beclin1) and lysosomal (CTSB, LAMP2) molecules in 350 gliomas using immunohistochemistry, immunofluorescence, immunoblotting and qPCR. Autophagy was induced pharmacologically or by altering oxygen and nutrient levels. Our results show that autophagy is enhanced in astrocytomas as compared to normal CNS tissue, but largely independent from the WHO grade and patient survival. A strong upregulation of LC3B, p62, LAMP2 and CTSB was detected in perinecrotic areas in glioblastomas suggesting micro-environmental changes as a driver of autophagy induction in gliomas. Furthermore, glucose restriction induced autophagy in a concentration-dependent manner while hypoxia or amino acid starvation had considerably lesser effects. Apoptosis and autophagy were separately induced in glioma cells both in vitro and in vivo. In conclusion, our findings indicate that autophagy in gliomas is rather driven by micro-environmental changes than by primary glioma-intrinsic features thus challenging the concept of exploitation of the autophago-lysosomal network (ALN) as a treatment approach in gliomas.
- Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae (2007)
- Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative clamp protein, PCNA. We have analyzed the contributions of ubiquitin and PCNA binding to damage bypass and damage-induced mutagenesis in Polymerase {eta} (encoded by RAD30) from the budding yeast Saccharomyces cerevisiae. We report here that a ubiquitin-binding domain provides enhanced affinity for the ubiquitylated form of PCNA and is essential for in vivo function of the polymerase, but only in conjunction with a basal affinity for the unmodified clamp, mediated by a conserved PCNA interaction motif. We show that enhancement of the interaction and function in damage tolerance does not depend on the ubiquitin attachment site within PCNA. Like its mammalian homolog, budding yeast Polymerase {eta} itself is ubiquitylated in a manner dependent on its ubiquitin-binding domain.
- IKKα controls ATG16L1 degradation to prevent ER stress during inflammation (2017)
- Inhibition of the IκB kinase complex (IKK) has been implicated in the therapy of several chronic inflammatory diseases including inflammatory bowel diseases. In this study, using mice with an inactivatable IKKα kinase (IkkαAA/AA), we show that loss of IKKα function markedly impairs epithelial regeneration in a model of acute colitis. Mechanistically, this is caused by compromised secretion of cytoprotective IL-18 from IKKα-mutant intestinal epithelial cells because of elevated caspase 12 activation during an enhanced unfolded protein response (UPR). Induction of the UPR is linked to decreased ATG16L1 stabilization in IkkαAA/AA mice. We demonstrate that both TNF-R and nucleotide-binding oligomerization domain stimulation promote ATG16L1 stabilization via IKKα-dependent phosphorylation of ATG16L1 at Ser278. Thus, we propose IKKα as a central mediator sensing both cytokine and microbial stimulation to suppress endoplasmic reticulum stress, thereby assuring antiinflammatory function during acute intestinal inflammation.
- BAG3 overexpression and cytoprotective autophagy mediate apoptosis resistance in chemoresistant breast cancer cells (2018)
- Target-specific treatment modalities are currently not available for triple-negative breast cancer (TNBC), and acquired chemotherapy resistance is a primary obstacle for the treatment of these tumors. Here we employed derivatives of BT-549 and MDA-MB-468 TNBC cell lines that were adapted to grow in the presence of either 5-Fluorouracil, Doxorubicin or Docetaxel in an aim to identify molecular pathways involved in the adaptation to drug-induced cell killing. All six drug-adapted BT-549 and MDA-MB-468 cell lines displayed cross resistance to chemotherapy and decreased apoptosis sensitivity. Expression of the anti-apoptotic co-chaperone BAG3 was notably enhanced in two thirds (4/6) of the six resistant lines simultaneously with higher expression of HSP70 in comparison to parental controls. Doxorubicin-resistant BT-549 (BT-549rDOX20) and 5-Fluorouracil-resistant MDA-MB-468 (MDA-MB-468r5-FU2000) cells were chosen for further analysis with the autophagy inhibitor Bafilomycin A1 and lentiviral depletion of ATG5, indicating that enhanced cytoprotective autophagy partially contributes to increased drug resistance and cell survival. Stable lentiviral BAG3 depletion was associated with a robust down-regulation of Mcl-1, Bcl-2 and Bcl-xL, restoration of drug-induced apoptosis and reduced cell adhesion in these cells, and these death-sensitizing effects could be mimicked with the BAG3/Hsp70 interaction inhibitor YM-1 and by KRIBB11, a selective transcriptional inhibitor of HSF-1. Furthermore, BAG3 depletion was able to revert the EMT-like transcriptional changes observed in BT-549rDOX20 and MDA-MB-468r5-FU2000 cells. In summary, genetic and pharmacological interference with BAG3 is capable to resensitize TNBC cells to treatment, underscoring its relevance for cell death resistance and as a target to overcome therapy resistance of breast cancer.
- Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy (2017)
- The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of its distinct domains. In mammalian cells, the ER is degraded via a selective autophagy pathway (ER-phagy), mediated by two specific receptors: FAM134B, responsible for the turnover of ER sheets and SEC62 that regulates ER recovery following stress. Here, we identified reticulon 3 (RTN3) as a specific receptor for the degradation of ER tubules. Oligomerization of the long isoform of RTN3 is sufficient to trigger fragmentation of ER tubules. The long N-terminal region of RTN3 contains several newly identified LC3-interacting regions (LIR). Binding to LC3s/GABARAPs is essential for the fragmentation of ER tubules and their delivery to lysosomes. RTN3-mediated ER-phagy requires conventional autophagy components, but is independent of FAM134B. None of the other reticulon family members have the ability to induce fragmentation of ER tubules during starvation. Therefore, we assign a unique function to RTN3 during autophagy.
- Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis (2014)
- Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor (TNF) signaling activation. Mice lacking Sharpin, a critical subunit of LUBAC, spontaneously develop inflammatory lesions in the skin and other organs. Here we show that TNF receptor 1 (TNFR1)-associated death domain (TRADD)-dependent TNFR1 signaling in epidermal keratinocytes drives skin inflammation in Sharpin-deficient mice. Epidermis-restricted ablation of Fas-associated protein with death domain (FADD) combined with receptor-interacting protein kinase 3 (RIPK3) deficiency fully prevented skin inflammation, while single RIPK3 deficiency only delayed and partly ameliorated lesion development in Sharpin-deficient mice, showing that inflammation is primarily driven by TRADD- and FADD-dependent keratinocyte apoptosis while necroptosis plays a minor role. At the cellular level, Sharpin deficiency sensitized primary murine keratinocytes, human keratinocytes, and mouse embryonic fibroblasts to TNF-induced apoptosis. Depletion of FADD or TRADD in Sharpin-deficient HaCaT cells suppressed TNF-induced apoptosis, indicating the importance of FADD and TRADD in Sharpin-dependent anti-apoptosis signaling in keratinocytes.
- Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications (2012)
- Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes. What was once regarded as a mere signal for protein degradation has turned out to be a major regulator of molecular signalling networks. Deregulation of ubiquitin signalling is closely associated with various human pathologies. Here, we summarize the current knowledge of ubiquitin signalling in immune deficiencies and cancer as well as the available therapeutic strategies targeting the ubiquitin system in combating these pathogenic conditions.


text:
Our Classic Landscape SetsRead more
John Hersey was very much inspired by the surrounding countryside here at Unison Colour. Influenced by the constant changes in…
New Dark ShadesRead more
Coming soon to the Unison Colour Collection…..New Dark shades…. Unison Colour currently hold 374 different shades of pastel ranging from…
Pure powdered pigmentRead more
A pastel is a stick of pure powdered pigment combined with a natural binder. As a medium, it sits comfortably…
What some of our Associate Artists think.Read more
Here at Unison HQ, we know how beautiful our pastels are & how much time is taken in the creation…
Posts tagged with 'Fionna Carvell'
Unison Colour > Fionna Carvell

subset: commoncrawl


text:
You don't have any saved vehicles!
Look for this link on your favorites:
Once you've saved some vehicles, you can view them here at any time.
The 2019 Ram 1500 beats the 2018 Ford F-150 when it comes to several key performance features and specs.
Standard V6 Engine
Air Suspension
Class-exclusive TorqueFlite® 8-speed automatic transmission
The 2019 Ram 1500 is offered with a number of premium features you won't find available on the 2018 Ford F-150, including:
See the difference in person. Test drive the 2019 Ram 1500 near Salem today at Wilsonville Jeep Ram, where we have a number of new vehicles specials going on, as well as a helpful online payment calculator that can help you estimate your monthly payments. While you're here, check out inventory of Black RAM 1500 trucks.
No matter if you prefer the crisp, aromatic flavors of a light white wine or the savory richness of a deep red vino, there's one thing you know for certain: Wine is essential to life. But rather than cozying up on your couch and sipping on a glass of your favorite rose, why not try…
If you call Portland, OR, home and you appreciate a well-crafted beer, you're in luck. We've found four breweries in the Portland area that are definitely worth exploring. Base Camp Brewing Company, Deschutes Brewery, Ecliptic Brewing, and Great Notion Brewing all have memorable experiences in store for you. Continue reading below for brief descriptions of…
Let's face it: Who wouldn't want to live in the town you call home, Woodburn, OR? Cozily situated amongst the sprawling landscapes of the Willamette Valley, this quaint town serves as the perfect place to purchase a picturesque, picket-fenced abode. Before you begin your house-hunting adventures, though, you want a skilled professional with plenty of…
You don't have any saved vehicles!
Look for this link on your favorites:
Once you've saved some vehicles, you can view them here at any time.
(503) 498-6637Call Now
25600 SW Parkway Center Drive • Wilsonville, OR 97070Get Directions
Open Today! Sales: 9am-7pm
Open Today! Service: 7am-6pm
Open Today! Parts: 7am-6pm
Phone: (503) 498-6637http://maps.google.com/?q=25600%20SW%20Parkway%20Center%20Drive%2C%20Wilsonville%2C%20OR%2097070


text:
There is a comprehensive training program showing you step-by-step how to get your business up and running. This is complemented by live coaching three times a week, and a supportive Facebook group with regular live broadcasts from the CEO Dean Holland. There's access to in-depth traffic training from Justin Brooke, one of the world's most sought-after online traffic experts.
A challenge with a lead-based commission structure is fraud prevention. If the form is easy to complete and the payout high enough, a dishonest affiliate can determine ways to auto-fill that form and collect commission on bogus leads. To prevent this, you would need a dedicated affiliate manager to police the quality of inbound leads. Warning signs include multiple leads originating from the same IP address, or patterns in data entry such as spelling variations on a single name — such as "Jonathan Smith," "Jon Smith," and "J. E. Smith." When you detect fraud, boot the affiliate from the program immediately, and inform the network. And don't forget to reverse any recorded leads associated with the bad affiliate.
To create an effective DMP, a business first needs to review the marketplace and set 'SMART' (Specific, Measurable, Actionable, Relevant and Time-Bound) objectives.[60] They can set SMART objectives by reviewing the current benchmarks and key performance indicators (KPIs) of the company and competitors. It is pertinent that the analytics used for the KPIs be customised to the type, objectives, mission and vision of the company.[61][62]
The 900-Number Rule requires that ads for pay-per-call services disclose the cost of the call. Ads for services that promote sweepstakes or games of chance, provide information about a federal program (but are not sponsored by a federal agency), or target individuals under 18 years of age require additional disclosures. Ads for 900-numbers cannot be directed to children under 12 unless the ads deal with a bona fide education service, as defined by the Rule.
Affiliate marketing is also called "performance marketing", in reference to how sales employees are typically being compensated. Such employees are typically paid a commission for each sale they close, and sometimes are paid performance incentives for exceeding objectives.[25] Affiliates are not employed by the advertiser whose products or services they promote, but the compensation models applied to affiliate marketing are very similar to the ones used for people in the advertisers' internal sales department.
Another strategy to keep in mind is to leave room for seasonal and temporary commission increases. You may not be able to pay your reps at 18% all year round, but maybe you can bump them up for a few weeks each year to help juice your revenue and keep reps motivated. It works, and it's another way to stay competitive in your niche even if your rates are on the lower side of the general range.
MaxBounty pride themselves on the diversity of campaigns offered to their affiliates. They have over 1,500 programs ranging from gaming, to finance, and dieting, with options to receive your commissions as CPA (cost per action like making a sale), CPL (cost per lead), mobile, or PPC (pay per call.) Allowing you to structure your promotions in a way that works best for you.
In the beginning, the operating expenses of the affiliate business are almost non-existent, comparing to other industries. You work online so that you can do it from your home well enough and then you only have the basic electricity and ISP subscription costs to cover. Optionally, there are additional expenses related to setting up a domain, web hosting operator and also some minor costs about designing layout, etc. - Provided that you decide to establish your affiliate marketing website.
Leadpages is the topmost tool for internet marketers. As a tool, they let anyone create a landing page within minutes & add it on their platform including WordPress, Drupal & all the popular platforms you can think of. I have been using them for almost a year & I must say it's a great investment for an end user. At the same time, they offer an affiliate program which lets you earn a lifetime commission of 30%.
We offer a prescription discount program that pay ever time the card is used. You market the card to persons without a medical plan and they will save substantially at there pharmacy on medication. Everyone in the United States can use the card, except the card can't be used in conjugation with insurance, some times our plan cost is less then the Co-Pays and can be used instead of insurance. The card is reusable with no cost or fees ever. So your offering a program that really can help people with there prescription cost and making a commission also.
Individual sellers and companies offering products or services have to deal with their consumers and ensure they are satisfied with what they have purchased. Thanks to the affiliate marketing structure, you'll never have to be concerned with customer support or customer satisfaction. The entire job of the affiliate marketer is to link the seller with the consumer. The seller deals with any consumer complaints after you receive your commission from the sale.
In April 2008 the State of New York inserted an item in the state budget asserting sales tax jurisdiction over Amazon.com sales to residents of New York, based on the existence of affiliate links from New York–based websites to Amazon.[45] The state asserts that even one such affiliate constitutes Amazon having a business presence in the state, and is sufficient to allow New York to tax all Amazon sales to state residents. Amazon challenged the amendment and lost at the trial level in January 2009. The case is currently making its way through the New York appeals courts.
An additional note that must be made at this phase is: do keep in mind the LTV or the life-time value of your customer here. In certain scenarios (e.g.: subscription-oriented affiliate programs) it makes sense paying significantly higher commissions on the customer's initial payment to the company when the latter knows that they will make much more (from the same customer) on future payments. More about it later in this text.
Retaining customers and managing customer service related issues gets problematic at times. Fortunately, as an affiliate, you don't need to bother about that. All you care about is your commission, so anytime you get a post-sale query, you just pass such requests on to the merchant's customer service team and wash your hands clean of the entire matter.
Two other practical limitations can be seen in the case of digital marketing. One,digital marketing is useful for specific categories of products,meaning only consumer goods can be propagated through digital channels.Industrial goods and pharmaceutical products can not be marketed through digital channels. Secondly, digital marketing disseminates only the information to the prospects most of whom do not have the purchasing authority/power. And hence the reflection of digital marketing into real sales volume is skeptical.[citation needed]
This is one area that is often overlooked as an "out of my hands" part of the affiliate marketing funnel. Once you've sent a visitor to the merchant site, all you can do is cross your fingers and hope they ultimately complete whatever action is necessary for you to get your commission. That's partially true I suppose. But you have more input here than you may realize.
(c) You will be solely responsible for providing personnel to assist Amazon customers with making purchases through the Local Associates Program. Without limiting the generality of the foregoing, you will design a reasonable training program designed to (1) educate your employees about Local Associates Program offerings, (2) use your expertise to assist Amazon customers with evaluating and making purchasing decisions regarding Local Associates Products, and (3) optimize customer experiences with the Local Associates Program. Further, you will implement the training program for all store managers and associates at each Local Associates Facility. With respect to any Amazon customer data received by you or your personnel in connection with purchases of Local Associates Products, you will ensure the security and prompt destruction of such customer data.
He is the owner of jeffbullas.com. Forbes calls him a top influencer of Chief Marketing Officers and the world's top social marketing talent. Entrepreneur lists him among 50 online marketing influencers to watch. Inc.com has him on the list of 20 digital marketing experts to follow on Twitter. Oanalytica named him #1 Global Content Marketing Influencer. BizHUMM ranks him as the world's #1 business blogger. Learn More
As an affiliate for Boatbookings, you will receive 20% of their revenue - effectively meaning your commission will be about 4% of any sales from your referrals. You also receive 10% of any commissions Boatbookings make on repeat customers who were your referrals. They do have a minimum charter value of 3,000 ($/€/£/etc) before commissions are earned.
The Commissions Report table gives you information about your sales. You can see on what date they were created what type of plan was purchased, and the campaign from which the sale has originated. If you only refer clients with your affiliate link directly without using campaigns, you will see that in the column "default". The last 2 columns show what the status of a sale is and what commission you can expect for it.
Another disadvantage is that even an individual or small group of people can harm image of an established brand. For instance Dopplegnager is a term that is used to disapprove an image about a certain brand that is spread by anti-brand activists, bloggers, and opinion leaders. The word Doppelganger is a combination of two German words Doppel (double) and Ganger (walker), thus it means double walker or as in English it is said alter ego. Generally brand creates images for itself to emotionally appeal to their customers. However some would disagree with this image and make alterations to this image and present in funny or cynical way, hence distorting the brand image, hence creating a Doppelganger image, blog or content (Rindfleisch, 2016).
Understand the different sales models. The most common forms of paid channel advertising are cost-per-mille (CPM) and cost-per-click (CPC). CPM ads are the banners you see across the tops of webpages. You are billed a flat rate based on the number of times the ad is displayed. CPC ads are the paid advertising results you see on a Google search results page or in the side margin on a Facebook page. You pay for every click on your ad.[17]
Aweber offers a lucrative 30% lifetime commission to their affiliates. Getting user onboard is easy as they offer free 30 days trial, which is compelling enough for users to give it a shot. And let me tell you, fellas, you won't be disappointed with their email marketing solution. They have everything which you need in a modern email marketing tool for your business. Anyways, for affiliates 30% lifetime commission sounds like a win-win to me. The only downside is their payment method for affiliates. They still offer old-age check system & yet to integrate new-age payment methods.
Understand the basics of how affiliate marketing works. Many online retailers who sell products or services offer affiliate programs. If you decide to sign up for a company's affiliate program, you get a tracking link to put on your blog. When visitors click on that link, the link stores a cookie in their browser that remains for a set period of time, such as 60 days. If the visitor purchases a product from that merchant site within the time period, you earn a sales commission.[26]
Many affiliate programs run with last-click attribution, where the affiliate receiving the last click before the sale gets 100% credit for the conversion. This is changing. With affiliate platforms providing new attribution models and reporting features, you are able to see a full-funnel, cross-channel view of how individual marketing tactics are working together. For example, you might see that a paid social campaign generated the first click, Affiliate X got click 2, and Affiliate Y got the last click. With this full picture, you can structure your affiliate commissions so that Affiliate X gets a percentage of the credit for the sale, even though they didn't get the last click.
Recurring affiliate programs are definitely the way to make serious income online. If you can add high paying affiliate programs, then you will notice a big increase in your monthly revenue which will allow you to go full time if that is your ambition. Harsh has a good list of programs in the internet marketing field but there are residual programs in many other niches such as health and beauty. So no matter what the topic of your blog/site, look out for some form of recurring income otherwise you are really missing out.
We will determine suitability at our sole discretion. If we reject your application due to unsuitable content, you may reapply at any time once you have complied with our suitability requirements. However, if at any time we 1) reject your application for any other reason or 2) terminate your account in connection with any violation or abuse (as determined in our sole discretion), you cannot attempt to re-join the Associates Program without our advance authorization. Advance authorization may be initiated by completing the Contact Associates Customer Service form available here.
You can also establish commission tiers based on specific product categories. For example, you could pay 2 percent revenue share on electronics, and 10 percent on home decor, since the former carries a lower profit margin than the latter. A challenge of working with this dual structure is the technical integration. You will need to create a product feed for the affiliate network, and for each affiliate transaction that occurs you will have to submit item-level data to distinguish, say, electronics from home decor. Neither task is particularly challenging, but it does require some work.
The development of digital marketing is inseparable from technology development. One of the key points in the start of was in 1971, where Ray Tomlinson sent the very first email and his technology set the platform to allow people to send and receive files through different machines.[8] However, the more recognisable period as being the start of Digital Marketing is 1990 as this was where the Archie search engine was created as an index for FTP sites. In the 1980s, the storage capacity of computer was already big enough to store huge volumes of customer information. Companies started choosing online techniques, such as database marketing, rather than limited list broker.[9] This kind of databases allowed companies to track customers' information more effectively, thus transforming the relationship between buyer and seller. However, the manual process was not so efficient.
ClickBank allows you to join for free, and the approval process is virtually automatic, so it's a great choice for people entering the affiliated game for the first time. ClickBank has a ton of information, including FAQs, walk-throughs, and videos available, so the barrier to entry is quite low. There's also a (paid) program called ClickBank University with courses and assistance from experienced marketers.
There will be NO commission payments paid on PERSONAL USE Sales of the Product - meaning, if the only purpose in joining this affiliate program was to get a commission on a sale for Personal USE of Click Funnels, that's not cool. We do track and reconcile every sale – and in cases where an affiliate has a single sale to themselves, a commission will NOT be paid on that sale. That's simply NOT FAIR to the affiliates who have promoted in good faith only to have one of their prospects join the affiliate program to get their own commission and cut the original affiliate out.
4. Sales incentives. Structure your commission rates so that you have additional margin to offer sales incentives. For example, perhaps you are launching a new product line and you want affiliates to focus their marketing efforts on it. If you have room in your commission structure, you can offer a temporary increase — or perhaps sales bonuses — for hitting established revenue targets. I addressed sales incentives here previously, in "Affiliate Marketing: 3 Incentives to Drive Sales."
As search engines have become more prominent, some affiliate marketers have shifted from sending e-mail spam to creating automatically generated web pages that often contain product data feeds provided by merchants. The goal of such web pages is to manipulate the relevancy or prominence of resources indexed by a search engine, also known as spamdexing. Each page can be targeted to a different niche market through the use of specific keywords, with the result being a skewed form of search engine optimization.


text:
Student of: Period 1 Scratcher Joined 1 year, 9 months ago United States
About me
Hi. 10 facts : Fact 1: You are reading this. Fact 2: You can't say the letter 'm' without touching your lips. Fact 3: You just tried it. Fact 4: You're smiling. Fact 6: You're smiling or laughing Fac
What I'm working on
NOTHING!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!The last part got cut off in the about me part. sorry:)
Featured ProjectThe Game
What I've been doing
Shared Projects (6)View all
Favorite Projects (76)View all
- Mope.io Sandbox v.1.7 by poker10
- Platformer v0.2 by 26SamuelT
- Platformer v0.1 by 26SamuelT
- Blob - RPG Platformer v0.9 by firstject
- Pop the Lock by FreNZyFIRE
- ❤Pencil Platformer❤ by Awesomeglazeddonut
- -BreadMan-'s Terraria Bosses by -BreadProjects-
- Terraria by 26cyrusg
- The Ninja 6 by Will_Wam
- Light Knight by Viking89
- Fractured Forest by Georgic
- Golf by SerialGamer
- New Rally X by RokCoder
- Textured Maze (Full Game) by RokCoder
- Sword Master by TheNiftyArrow
- The Ninja 5 by Will_Wam
- Blob Story by Mathaino
- Super Slime Smash (v1.15) by theChAOTiC
- The Adventures of Will_Wam by thefunneylookingcat
- Hideout-3D by Lokuin
Studios I'm Following (7)View all
Studios I Curate (16)View all
- @26 Studio
- teh remix studio(and originals too!)
- Laugh just like Ronaldo!(Messi is better)
- Teh offcial platformer studio
- Teh random studio
- Pen Studio
- Meme Studio
- https://WE.BLOW.BOMBS.org
- Hamburgers
- Will_Wam Fan Club
- teh Mig tudio
- my name is jeff
- [CLOSED] Teh Official Potato Studio
- don't tell anyone about this
FollowingView all
FollowersView all
- Comments loading...


text:
Reversing A Failure of Imagination
When you're young, it's easy to imagine. The way life could be. What you could become. How the world might change. It all seems possible. My neighbor and I used to pretend we were Spy Kids (a terrible, but great '90s movie). We had these backpacks filled with potions (his mom's moisturiz
Post to Tumblr


text:
This Beautiful Edwards Hill Single Family Residence, Located at 18582 Derby Circle, is Back on the Market
Back on the market as of April 11th at 8:27am, this Mediterranean home was originally listed on April 10th in 2019. The property is being listed at a price of $1,898,000 , the same as its original list price. This 5 bedroom, 3 full baths, 1 half bath residence is located on Derby Circle, a prime area in .
With a total floorspace of 3,540 square feet, this beautiful home comes in at $536.16 per square foot. That's 8.42% lower than the neighborhood average. There are also 3.00 garage spaces available for parking.
Originally built in 2000, this 2-story home sits on a 9,076 square foot lot.
See the full listing here:
Edwards Hill | 18582 Derby Circle CA 92648
Listing provided courtesy of Jody Clegg at Compass.


text:
Category : Template.
Topic : Word invoice templates uk. Author : Reaves Daniels.
Posted : Sat, May 18th 2019 11:18 AM.
Format : jpg/jpeg.
Billing is the most essential and substantial part of a business. Without this process your business is unlikely to survive a long time. The billing process moves the money in your firm, hopefully more in than out. This is why it is very important to come across very professional in this situation.


text:
This book isn't one of my best ones. If you want to read it, be my guest. But I can assure you my writing has certainly improved since this one was published. Please, enjoy!
A Christian Romance Novel:
Sometimes, you need light in your world of darkness. People will say it's a friend or lover, but that's not the case. After all I have gone through, I want for God to be the light in my life. He will no longer let me sit in a world of darkness. I will be released from my dark prision, and I will step foot into the light, because that is where God is.
Willow Andrews: musician, kind-hearted, friend to all, and above all else, a Christian
Hunter Morris: bad boy fascade, broken but won't show it, and lost from God
When Hunter gets in trouble at school, he winds up needing to pair up with Willow to help them both out with their troubles. The clock counts down to the final moment of a choir concert, and hearts are put on the line.
A possesive boyfriend, a crazy ex-girlfriend, and a gaurdian angel all find their way into Hunter's life. With him being a lost soul, straying from the path of God, it's up to Willow to help him find a way to get back in tune with the Lord, or else his soul might be lost forever.
Highest Ranking #102 in Spiritual
- Chapter One
- Chapter Two
- Chapter Three
- Chapter Four
- Chapter Five
- Chapter Six
- Chapter Seven
- Chapter Eight
- Chapter Nine
- Chapter Ten
- Important A/N
- Chapter Eleven
- Chapter Twelve
- Chapter Thirteen
- Chapter Fourteen
- Important Update
- Chapter Fifteen
- Chapter Sixteen
- Chapter Seventeen
- Chapter Eighteen
- Chapter Nineteen
- Chapter Twenty
- Chapter Twenty-One
- Chapter Twenty-Two
- Chapter Twenty-Three
- Chapter Twenty-Four
- Chapter Twenty-Five
- Chapter Twenty-Six
- Chapter Twenty-Seven
- Chapter Twenty-Eight
- Chapter Twenty-Nine
- Chapter Thirty
- Chapter Thirty-One
- Chapter Thirty-Two
- Chapter Thirty-Three
- Chapter Thirty-four
- Chapter Thirty-five


text:
Made of leather, the thumbstall is used by the gunner to stop the vent when the barrel is being swabbed out so that no residue or hot ashes blow up the vent and prematurely ignite the next powder load. The leather tie is tied around the wrist of the user to keep the thumbstall in position. Hand-cut and stitched in Gettysburg, PA.
May take 1-2 weeks to be made if not in-stock. Please call before ordering if you need it by a certain date.


text:
Heat refocus for Highveld clash with Stars
Updated | By Nick Tatham/Gameplan Media
The Durban Heat will be looking to erase Wednesday night's disappointing loss to the Paarl Rocks when they travel to the Bidvest Wanderers to take on the Jozi Stars in their next Mzansi Super League fixture on Friday evening.
The Durban Heat will be looking to erase Wednesday night's disappointing loss to the Paarl Rocks when they travel to the Bidvest Wanderers to take on the Jozi Stars in their next Mzansi Super League fixture on Friday evening.
The Heat were unable to answer the questions that the Paarl Rocks posed with the ball and despite the game being reduced to a nine overs a side slog-fest they couldn't chase down the substantial 113 they needed to win.
Wednesday's loss has meant that the Heat have got themselves into a situation where a win on Friday is going to be crucial to their chances in the competition.
Wednesday's bowling display aside, the Heat bowlers have been able to keep them in games. It has been the batting element that has let them down thus far in the tournament and captain Albie Morkel knows that his team have the ability to turn their fortunes around.
"We have some really experienced first class cricketers in our squad and they know that individually they need step up," he said.
"No coach can do it for them. They have to find that magic moment themselves. It might be a nick through the slips or one good shot through the covers for a guy like Hashim (Amla) to be back to full form.
"That's how quickly the change can happen."
Heading into the must-win clash with the Stars on Friday, the play-off equation for Morkel and his team has become fairly clear.
"We now know that we probably have to win five of our next six games to have a chance to make the play-offs.
"That's fine for us and we look forward to taking on that challenge and I still have full confidence in the squad that we can do that," Morkel added.
The Heat top order has battled to get the team off to the starts that they would have liked which gives the likes of David Miller, Heinrich Klaasen and Morkel the chance to cash in from the early momentum.
Morkel has stressed the importance of the next week and a half which sees the Heat play five games between Friday, 30 November and Sunday, 9 December.
"Ten games can go pretty quickly and I would like us to get on a bit of a roll now," he emphasised.
"If we can win three or four and get into the play-offs then anything can happen but we know that we need to make a move now and the next week is going to be very important for us."
The Heat and the Jozi Star square up for their first meeting of the 2018 Mzansi Super League at the Bidvest Wanderers starting at 7pm on Friday.
Show's Stories
The fate of Africa's most iconic trees are in the hands of these guardians
The tree of life is dying. So these guardians are taking a stand.Thandolwethu on East Coast Radio 2 hours ago
Beyoncé and Donald Glover 'Lion King' duet leaves Thandolwethu wanting more
"It's a classic movie with a star-studded line-up, what more could we as...Thandolwethu on East Coast Radio 2 hours ago


text:
If you're looking for the perfect new home in zip code 75206, you've come to the right place. NewHomeSource.com is the Internet's leading provider of new homes in 75206. Choose from a list of 6,522 new homes in 595 new home communities, all built by 107 different builders. These homes range in price from $53,230 to $24,000,000. With this many homes at this price range, you can easily find the features you want at the price you need. If you're looking to control the build process, you can find 4,387 plan homes. If you need a home right this instant, we'll show you 1,690 spec homes too. These homes range in size from 1,004 to 12,000 square feet, they have 1 to 7 bedrooms, and they have 1 to 7 bathrooms. Whathever you choose, you can't go wrong using NewHomeSource.com to get your new home search started in 75206.!.
Lakewood Hills by Beazer Homes
Read Reviews
Close Out
From $372,990 - $489,990
2000 Hollowcreek Trail
Carrollton, TX 75010
Ingram Terrace by David Weekley Homes
From $383,990 - $503,990
5437 Harbour Road
Richardson, TX 75082
The Canals at Grand Park by CB JENI Homes
Coming Soon
Diamond Point Lane & Legacy Drive
Frisco, TX 75034
Cottonwood Creek by Meritage Homes
Close Out
From $470,190
By Appointment Only
Frisco, TX 75033
Villas at Parker by Meritage Homes
From $349,990 - $430,190
By Appointment Only
Carrollton, TX 75010
Lexington Country Signature Series by Landon Homes
From $897,990
13081 Secretariat Blvd.
Frisco, TX 75035
Hagan Hill by Bloomfield Homes
Read Reviews
From $295,990 - $424,815
6008 Hagan Hill Pkwy
Mesquite, TX 75181
Enclave at Lake Highlands Town Center - Bungalow Series by David Weekley Homes
From $496,990 - $662,173
7113 Copperleaf Drive
Dallas, TX 75231
Prairie View by David Weekley Homes
Close Out
From $410,990 - $499,990
13651 Fieldcrest Road
Frisco, TX 75035
Stonehaven at The Tribute - The Manors by Meritage Homes
Close Out
From $479,990 - $589,990
8366 Bankside
The Colony, TX 75056


text:
rv interior paneling interior paneling repair rv interior paneling trim.
rv interior paneling canada seam tape wood camper wall panels transporter interiors,rv wall paneling trim interior seam tape replacement design steel panels,rv interior paneling repair wood tasty wall awesome bathroom decorating trim,rv wall paneling replacement trim interior ceiling for sale vinyl,rv interior wood paneling wall replacement trim,rv wall paneling seam tape interior repair trim wood,rv wall paneling replacement interior wood seam tape panels,interior wall panels ceiling buy rv wood paneling repair,rv interior paneling repair replacement wall coverings tips for painting the walls ceiling sale,rv interior wood paneling wall trim canada.
Related Post
Daybed Covers Ikea Curtain To Divide Room Colonial House Wall Accessory Essential Oils For Fleas In The House Wall Mount Magnifying Mirror Front Yard Landscaping Ideas Ranch House End Table Cabinet Storage Cubbies With Baskets Used Bounce House For Sale Tiffany Blue Lamp Costco Picnic Table Going A Wall Pickup Bed Carriage House Designs


text:
Fox News' Shep Smith interrupts Mitch McConnell's Senate speech to fact-check him
Fox News' Shep Smith on Tuesday cut away from Senate Majority Leader Mitch McConnell's impassioned argument for Donald Trump's border wall to fact-check him in real time.
After McConnell claimed he's optimistic that a "negotiated solution" resulting in a border wall will emerge between Congressional Democrats and Republicans that will pass both the House and the Senate, Smith laid down the law.
"Democrats insist that proposal is not possible," the host said.
Smith went on to detail the history of the border wall fight, noting that Trump campaigned on the promise that Mexico would pay for it before punting it to Congress after the country refused.
"Now the president says he will keep the government shut down, he said for months or years if necessary, while waiting for the funding which the House of Representatives says it will not give," he added. "So there's the impasse. One side or the other must budge at some point."
"At the moment the ones in charge of the purse strings are Democrats in the House of Representatives," Smith concluded, "and they're not giving him the money — at least not now."
Watch below:
Fox News host's insane anti-LGBT screed: Activists are trying to make kids transgender by 'eliminating gays'
Fox News host Greg Gutfeld went on a lengthy deep-dive into what he claims are the motivations of LGBT activists, falsely accusing them of trying to increase the number of transgender children by "eliminating gays."
There is exactly zero truth to Gutfeld's claims, which he made on Fox News' "The Five" on Monday, as Media Maters reports.
Breaking Banner
Hope Hicks denied under oath knowing about Trump's hush-money payments to Stormy Daniels
Former White House communications director Hope Hicks on Wednesday denied under oath knowing anything about the hush-money scheme set up by former Trump "fixer" Michael Cohen to pay off President Donald Trump's former mistresses.
"Hicks told lawmakers today that she did not have knowledge during 2016 campaign of hush-money payments made in run-up to election," reports CNN's Manu Raju. "Also she wouldn't discuss what she learned about those payments during her time at White House because of immunity claims."
Hicks told lawmakers today that she did not have knowledge during 2016 campaign of hush-money payments made in run-up to election, per sources. Also she wouldn't discuss what she learned about those payments during her time at WH bc of immunity claims https://t.co/GZWqzCzpGX
Federal Reserve chair defiant in face of Trump threats: 'The law is clear — I have a four-year term'
Federal Reserve Chairman Jerome Powell sounded a defiant note on Wednesday as he announced that there would be no further cuts to interest rates for the time being.
Even though President Donald Trump has been publicly calling for a rate cut to spur additional economic growth ahead of his reelection campaign, Powell kept interest rates at their current level and signaled that he did not foresee any interest rate cuts for the rest of the year.
Powell was asked by a reporter if he was concerned about being "demoted" by Trump in the wake of this announcement, the Federal Reserve Chairman said he wasn't worried.


text:
04528279 is referenced by 52 patents and cites 5 patents.
A monolithic catalyst, for the purification of exhaust gases from an internal combustion engine, comprising: an inert carrier; a film of alumina and rare earth oxides coated onto the surface of said inert carrier, wherein Ce and La are present in said film at an atomic ratio of Ce/La of 0.05-0.3 and the total content of rare earth oxides in said film is 2-50 wt. %, measured as R.sub.2 O.sub.3, wherein R is an element of the lanthanide series of the Periodic Table; and said film carries a catalyst component containing at least one element of the platinum family.


text:
most relevant
Search List
IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma...2005 Shabaana A Khader et al. JOURNAL OF IMMUNOLOGY cited 308 times
Aerosols, Animals, CD4-Positive T-Lymphocytes, immunology, metabolism, Dose-Response Relationship, Immunologic, Down-Regulation, genetics, Female, GTP-Binding Proteins,...
Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK.2005 Thorsten Hagemann et al. JOURNAL OF IMMUNOLOGY cited 221 times
Antigens, CD, biosynthesis, genetics, physiology, Basigin, Binding Sites, Breast Neoplasms, immunology, pathology, Cell Line, Transformed, Cell Line, Tumor, Cells, Cultured,...
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.FREE2005 Barbara Giabbai et al. JOURNAL OF IMMUNOLOGY cited 90 times
NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we...
IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells.FREE2005 Nuno L Alves et al. JOURNAL OF IMMUNOLOGY cited 70 times
Human naive CD8+ T cells are able to respond in an Ag-independent manner to IL-7 and IL-15. Whereas IL-7 largely maintains CD8+ T cells in a naive phenotype, IL-15 drives these...
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors.2005 Ilaria Tassi et al. JOURNAL OF IMMUNOLOGY cited 66 times
Adaptor Proteins, Signal Transducing, deficiency, physiology, Animals, Antigens, Ly, metabolism, CHO Cells, Cells, Cultured, Cricetinae, Cytotoxicity, Immunologic, genetics,...
Developmentally regulated intestinal expression of IFN-gamma and its target genes and the age-specific response to enteric Salmonella infection.2005 Sue J Rhee et al. JOURNAL OF IMMUNOLOGY cited 60 times
Adjuvants, Immunologic, biosynthesis, deficiency, genetics, physiology, Aging, immunology, Animals, Animals, Newborn, Enteritis, microbiology, pathology, Gene Expression...
IL-1 beta induces IL-6 expression in human orbital fibroblasts: identification of an anatomic-site specific phenotypic attribute relevant to thyroid-associated ophthalmopathy.2005 Beiling Chen et al. JOURNAL OF IMMUNOLOGY cited 57 times
Antigens, CD, biosynthesis, Cell Movement, immunology, Cells, Cultured, Cytokine Receptor gp130, Dexamethasone, pharmacology, Fibroblasts, enzymology, metabolism, Gene...
TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo.2005 Carl De Trez et al. JOURNAL OF IMMUNOLOGY cited 54 times
Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, deficiency, genetics, physiology, Animals, Antigens, Differentiation, biosynthesis, Apoptosis,...
Contribution of the lymphotoxin beta receptor to liver regeneration.2005 Robert A Anders et al. JOURNAL OF IMMUNOLOGY cited 51 times
Animals, DNA Replication, genetics, immunology, Dose-Response Relationship, Immunologic, Hepatectomy, Hepatocytes, metabolism, pathology, Hepatomegaly, Ligands, Liver...
Cyclooxygenase 2 inhibition promotes IFN-gamma-dependent enhancement of antitumor responses.2005 Sherven Sharma et al. JOURNAL OF IMMUNOLOGY cited 45 times
Adjuvants, Immunologic, antagonists & inhibitors, physiology, Animals, CD4-Positive T-Lymphocytes, drug effects, enzymology, immunology, Cancer Vaccines, administration...
Priceopen/close button
- 103
- 4


text:
Governments that fail to provide responses to the global climate crisis are doing so "at their own peril," former United Nations climate chief Christiana Figueres said during a visit to Toronto.
Figueres, a central figure behind the 2015 Paris Agreement, made the comments as she called for governments and tech companies to "go exponential" in their efforts to tackle the global climate emergency.
Her remarks come weeks after several reports have portrayed devastating impacts of the climate crisis, including the near extinction of one million species worldwide,100-year floods in Ontario and Quebec and raging forest fires in western Canada. In one of those reports, federal government scientists said that global greenhouse gas emissions would need to be reduced to "near zero" in the current century in order to avoid some of the harshest impacts of climate change.
Under Premier Doug Ford's Ontario government, the province has cancelled a series of policies, related to taking action to address the climate crisis (including slashing cap and trade, the 50 Million Tree Program and flood management funding), promising instead to introduce something new in its place. It introduced an outline of its new plan in November, without firming up details.
Similar actions are underway in Alberta where Premier Jason Kenney's newly-elected United Conservative Party government has already tabled legislation to scrap the province's carbon tax and announced it will dismantle elements of the former NDP government's climate change policies and replace them.
"There is no doubt that the global economy is decarbonizing. There's no doubt that those corporations that fail to participate in the solution, will simply fail to exist. And so those governments that want to protect those industries will not be able to do so in the end, and are only calling on their own demise," Figueres told National Observer in an interview.
"When the river is flowing in one direction and the entire global river is flowing towards decarbonization and someone takes a bucket and says, I'm going to start to throw water up the river, well, good luck on that," she said. "It doesn't change the course of history and it only slows down the progress and the thrust forward of those industries in your jurisdiction."
Figueres led the UN's global negotiating process that culminated in the 2015 Paris climate change agreement. She was in Toronto to visit the Collision Conference, an annual gathering of global technology industry leaders and experts, to talk about how technology was "the portal to addressing climate change."
Delighted to be joining the conversation here @WebSummit #Collision2019. Tech leaders agree. We can solve climate change and get clean air for everyone. pic.twitter.com/gcfjdAKAIY— Christiana Figueres (@CFigueres) May 22, 2019
She currently heads up Mission 2020, a global campaign which aims to push countries to rapidly scale up ambition on tackling climate change by 2020, when nations are required to submit their decarbonization plans as part of the formal adoption of the Paris Agreement.
Ahead of tackling high carbon sectors such as oil and gas, shipping and aviation, and auto manufacturing, Figueres emphasized that the top priority remained ensuring that governments and industries exercised "self responsibility."
The responsibility was made "lucidly clear" in October 2018 when the UN Intergovernmental Panel on Climate Change issued their report of the devastating impacts the world will experience if global temperatures were allowed to go above 1.5 degrees.
"We have to take 1.5 as our new north. That is difficult," she said, noting that reducing investments and recalibrating policies is a complicated matter.
But she also makes clear what happens if governments and industry don't take up this "new north:" a two-degree warmer world will produce two times as much infrastructure destruction, two to three times as much biodiversity loss, and two to three times as many people exposed to heat and food insecurity to the point of death.
"That is not a responsibility than any of us want to have on our shoulders," Figueres said.
While she explained that Canada has been "very responsible, very helpful for the Paris agreement," and the Justin Trudeau Liberal government have "marked a sea change from the previous administration," showing support for other governments as well in their decarbonization efforts, it can do more.
"Everybody needs to do more," Figueres said. "This is not about incremental ... Everybody needs to step up and go exponential as opposed to gradual and linear."
'This is actually the moment for total disruption'
Figueres remains optimistic because companies and financial institutions are embracing the 1.5 degree marker.
"Because it is so ambitious that it really unlocks ingenuity and total disruption, which is something that a lot of people actually quite enjoy and are very capable of," she said, gesturing to the Toronto Collision conference. "And this is not the moment for any gradual shift or any gradual change, this is actually the moment for total disruption in order to lay the groundwork for a much safer world."
She lists all the accomplishments the technology sector has made around the world: Harley Davidson is coming out with its first silent, electric motorbike. Most car manufacturers have set a date to move their automotive production services to electric.
But there are just as many challenges, Figueres notes. Electric vehicles won't make as big of an impact if we don't have clean grid. Right now, seven million people are killed every year because of air pollution, she said.
Making infrastructure energy and water efficient is also necessary, she said. In developed countries, the challenge is how to modernize existing infrastructure. In developing countries, the challenge is what kind of new infrastructure to build that will provide quality of life and address the climate crisis.
"Cities that are being built today need to be people friendly and not necessarily cement friendly," Figueres said. "They need to be community organized and not highway organized."
"Infrastructure policy is not being as aggressive as it should be," she added.
She also said that land-use policies are the weakest, in terms of tackling climate change. She said government could address this by taking action in areas such as climate-smart agriculture, reforesting degraded lands, restoring and regenerating degraded lands — everything that has to do with soil fertility and aquifer management.
Land-use changes were also identified in the UN biodiversity report as the key driving force of the extinction of one million species around the world.
Think that #ClimateChange is the only crisis facing #Nature?— IPBES (@IPBES) May 6, 2019
The @IPBES #GlobalAssessment Report is the first to rank the relative impact of drivers of #biodiversity loss.
1. Land/Sea Use Change
2. Direct Exploitation
3. Climate Change
4. Pollution
5. Invasive Species pic.twitter.com/QZvyB4xz4R
"I think it's become more normalized to apply advanced technologies and to continue to develop technologies for infrastructure and for energy and for transport. But we have a dearth of technologies that are going to help in the land use sector," Figueres said.
Technology can help solve this failure and, in fact, quicken the rate at which this sector responds to the climate crisis, she said.
Right now there is "a race between two exponentials," Figueres said. The first is the exponential growth of damages and threats from climate change. The second is the exponential growth in technological solutions, whether its renewables, batteries, electric vehicles, smart grids, clean transportation.
"The big question that we're facing right now is which of these two exponential curves is going to win the race," Figueres said. "Will we be succumbing to the threats of climate change because they are coming upon us faster and faster… or will we be able to grow the technological response in order to be able to at least abate the worst parts of climate change?"
"That is a race we have to win," she said. "In this century, we can't have technology growing just for growth's sake. It has to be purpose driven. There is a no other way."
Today's must read
As Trans Mountain readies shovels, First Nations vow to stop them
Shark fin ban sets an example for the world
An 'awful lot of room for intolerance' in Scheer's party: Trudeau
Scheer touts industry-friendly climate plan
Take two: Alberta lauds federal re-approval of Trans Mountain pipeline project
Who should bear the financial risk of flooding? Report lays out three options
Business leaders welcome pipeline approval but fear it may not be completed
RCMP seeks names of potential victims of coerced sterilization, Lucki says
Police name three men arrested after shooting at Raptors victory rally
Chief military judge's court martial in limbo after deputy recuses himself
Canadian Forces investigating after soldier dies while parachuting in Bulgaria
Blair says more gun-control action needed, signals no new steps before election
124 children affected by January gas leak that forced evacuation of Montreal school
Liberals to reject Senate changes to solitary confinement bill
How the Trudeau government responded to an oilpatch plan
The Juggernaut of corporate oil must be stopped
Trudeau government approves Trans Mountain
Remove bird feeders to battle spread of deadly parasite, bird society urges
Montreal's new Champlain Bridge to open June 24, six months behind schedule
U.S. ramps up concern over B.C. pollution; eight senators write to premier
Commons committee wants to curb criminal prosecutions of HIV non-disclosure
Fire triggers pollution concerns at US Steel coke plant
RCMP's secretive truth squad uses questionable science
Groups launch challenge of Quebec's secularism bill one day after it becomes law
Toronto hospital says surgery program will help trans patients 'live true lives'
Senate committee extends deadline for inquiry into Mark Norman case
Euphoria turns to fear after shots fired at massive Raptors victory rally
Liberals' balancing act between energy and the environment climaxes this week
New tool launched to shine light on ethnic media coverage of election issues
Deadline for cabinet to decide future of Trans Mountain expansion is today
In photos: Faith leaders rally to declare climate crisis
NDP pitches health-care overhaul ahead of federal election
Keep oil out of Nisga'a Nation territory — support Bill C-48
What the heck is the circular economy?
In praise of the Liberals' electric-vehicle incentives


text:
Hotel Castilla Real, Pereira
- Free cooked-to-order breakfast, free WiFi, and free parking
- Collect nights
Hotel Castilla Real, Pereirafrom $49
- Standard Twin Room
- Standard Double Room
- Basic Triple Room, 1 Bedroom
- Classic Quadruple Room, 1 Bedroom
More great choices
What's around Hotel Castilla Real, Pereira
- Heart of Pereira
- Andes - 1 min walk
- Magdalena River - 1 min walk
- Victoria Shopping Mall - 7 min walk
- Boliz - 7 min walk
- Olaya Herrera Park - 7 min walk
- Lucy Tejada Cultural Center - 9 min walk
- Pereira Gold Museum - 9 min walk
Getting around
- Pereira (PEI-Matecana Intl.) - 6 min drive
- Cartago (CRC-Santa Ana) - 31 min drive
- Manizales (MZL-La Nubia) - 53 min drive
- Armenia (AXM-El Eden) - 55 min drive
- Transportation Terminal Station - 14 min walk
- Airport shuttle (surcharge)
- Area shuttle (surcharge)
At a glance
Key facts
Hotel size
- This hotel has 24 rooms
- This hotel is arranged over 3 floors
- Check-in time 1 PM-midnight
- Check-out time is noon
Required at check-in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Parents must have child's birth certificate and photo ID *
- No cribs (infant beds)
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Airport shuttle (available on request) *
- Free self parking (limited)
- Area shuttle *
Payment types at the property
In the hotel
- Free cooked-to-order breakfast daily
- Restaurant
- Room service (during limited hours)
- Coffee/tea in a common area
- Use of nearby fitness center (discount)
- Conference space
- Meeting rooms
- Conference space size (feet) - 904
- Conference space size (meters) - 84
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Free newspapers in lobby
- Luggage storage
- Number of buildings/towers - 1
In the room
- Air conditioning
- Minibar
- Premium bedding
- Pillowtop mattress
- Private bathroom
- Rainfall showerhead
- Shower only
- Free toiletries
- Hair dryer
- 32-inch LCD TV
- Cable TV channels
- Desk
- Free WiFi
- Free local calls
- Refrigerator
- Daily housekeeping
- In-room safe
Also popular with travelers from the USA
Hotel Castilla Real, Pereira's small print
If you are traveling with a child your property may require you to present the following documents: Parents traveling into Colombia with a child under 18 may be required to present the child's birth certificate and photo ID (passport for foreign visitors) upon check-in. If a relative or legal guardian is traveling into Colombia with the child, that relative or legal guardian may be required to present a notarized consent of travel signed by both parents and a copy of both parents' ID. If only one parent is traveling into Colombia with the child, that parent may be required to present a notarized consent of travel signed by the other parent. Visitors who plan to travel with children should consult with a Colombian consulate office prior to travel for further guidance.
Only registered guests are allowed in the guestrooms.
This property does not have elevators.
For transfers, guests must contact the property 24 hours prior to arrival at the number on the booking confirmation.
Also known as
- Castilla Real
- Castilla Real Pereira
- Hotel Castilla Real
- Hotel Castilla Real Pereira
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- The national sales tax (19%) is charged upon check-out to citizens of Colombia regardless of length of stay and to foreigners staying 60 consecutive days or more. Foreigners on a tourist visa are exempt from this tax. Furthermore, the tax may apply per room when the room is shared by a taxable and a nontaxable guest.
- Resort fee: COP 8000 per person, per night
Optional extras
Rollaway beds are available for COP 45000 per night
Airport shuttle service is offered for an extra charge of COP 55000 per vehicle (roundtrip)
Area shuttle service is offered for an extra charge
We have included all charges provided to us by this property. However, charges can vary, for example, based on length of stay or the unit you book.
Didn't find the right property?Continue searching for Pereira, Colombia
Recent reviews
Superb 9.2 From 25 reviews
The room is a few litle; I will like only a few larger the room.
What makes this hotel great is its staff. We were greeted with a smile by everyone we met, and they went out of their way to help us with whatever we needed, whether it was ordering a taxi, offering us coffee, or even loaning us towels for a day trip elsewhere. Breakfast was fantastic, with enough variety to keep us looking forward to it every day of our 6-night stay. I really liked the option of sitting on the patio in the morning while we enjoyed our coffee. The rooms were small, but clean and comfortable, and surprisingly quiet for the location. The wi-fi never let us down, which was important because we used it to organize our days with family in the area. I was worried that my inability to speak Spanish would be a problem, but Danny (who appears to work there 24/7) is completely bilingual and we had no trouble communicating with the rest of the staff either. This was not a shiny new highrise hotel, but it is a great little taste of Colombian hospitality. I'd certainly go back.
Is the description of this hotel not correct? Tell us


text:
The Submariner James Bond model ref 6536
Rolex 6536 diving watch from the 1950's in original condition, one of Rolex most iconic sports watches. Introduced in 1955 the Rolex Submariner is one of the most collected sports watches by Rolex. The Rolex Submariner James Bond is a nickname given because Sean Connery wears the watch in his very first James Bond movie.
The Ref 6536/1 Submariner
The Rolex Submariner 6536 was introduced together with the ref 6538 brevet, also known as the Rolex 'Big Crown'. The 6536/1 came shortly after the introduction and has the improved 1030 chronometer movement. The 6538 Submariner could be considered as the real 'James Bond' sub as he was wearing the big crown variant in the movie.
Gilt dial
The early Submariner watches feature a radium gilt dial. These dials where delivered 'glossy', with many of the early submariner's the gloss layer disappeared from the dial due to humidity and/or the strongly radioactive lume on the dial and hands. The Rolex Submariner James Bond we offer for sale has the original dial and hands in unrestored condition. The Glossy dial has partly lost his gloss which gives the watch a natural patina with a beautiful brown tone. The lume on the hands and dial is present and untouched,
Original condition
The Rolex Submariner James Bond models are hard to find these days. Especially in original condition they are sought after by collectors. Some collectors even say the early Submariner's are going to be the most important watches in 2019 auctions.
Sean Connery was wearing a submariner 6538 in Dr. No (1962) & From Russia With Love (1963). The reference 6538 is pretty much the same watch as the 6536/1 except the bigger crown. The reference 6538 is commonly referred to as the 'big crown' submariner. A beautiful example of the 6538 recently sold for half a million dollar at Phillips auction.
see link to the auction results: Link Auction results
Rolex 6536
- ref 6536-1 submariner
- year 1957
- 37mm case
- full original condition
- gilt dial and hands
- with box / no papers
- 1 year guarantee
Please contact us directly by phone or mail for any questions related to this vintage rolex submariner
High-end Vintage Timepieces
Rolex Submariner 6536-1 'James Bond' from 1957Sold
Rolex Daytona ref 16528 'Inverted 6' full gold and diamond indicesPrice on Request
Gouden Rolex day-date referentie 1803 uit 1972Sold
Rolex Daytona horloge geelgoud, leren band ref 16518Price on Request
Rose gouden Vintage Rolex 34mm horloge uit de jaren 30′€5,400.00
Heuer Carrera chronograaf in perfecte conditie€7,500.00
Heuer Autavia vintage chronograph ref 2446 from 1968€13,250.00
Rolex 6239 Daytona vintage from 1969 'Tropical Dial'Price on Request
Breguet Type 20 / XX Vintage Pilots 'flyback' chronograph from 1976Price on Request
Rolex 16660 Sea Dweller 'Triple Six' matte dial 1984Sold
Omega Seamaster Flat Jedi from with box and papers from 1974€3,200.00
Rolex Cosmograph Daytona two tone 'Cream Dial' from 2002€11,500.00


text:
How to Heal a Hematoma at Home
Explore this Article Treating a Hematoma Healing a Hematoma through Diet Understanding Your Condition Article Summary Expert Q&A Related Articles References
There are 19 references cited in this article, which can be found at the bottom of the page.
A hematoma is a localized collection of blood underneath the skin that may appear as a reddish blue swelling (bruise). It is usually due to a blunt trauma to the body that causes a burst and leaking of blood vessels. A large hematoma can be dangerous, since it places pressure on the blood vessels and can thus obstruct blood flow. Though seeing your doctor is best, there are things you can do to heal mild or moderate hematomas at home.
Treating a Hematoma
1Rest and immobilize the injured part. Muscle activity and movement can irritate and increase the pressure on the soft tissues, which can trigger an inflammatory response and make your hematoma worse. Maintain relative rest for the first 48 hours after injury, if at all possible.[1]
- Immobilization that keeps you in a normal anatomical position (lying on your back with the palms and feet pointing forward) is helpful in the healing process and may prevent further damage. This is especially true for the extremities and joint areas.
2Apply a cold compress immediately after injury. This should be done immediately and repeated every few hours for 48 hours after injury. Apply an ice pack to the affected area right after you notice a hematoma starting to develop. Low temperature reduces blood flow, decreasing bleeding. Remember not to hold the ice pack on the skin for more that 15-20 minutes to prevent tissue damage. Wrap the ice pack in a cloth to prevent ice burn.[2]
- Use melting ice on a wet towel (18-27°C/64-80°F) and apply it to the site of injury for 10 minutes at a time. Repeat as necessary (4-8 times a day) to reduce the local skin temperature by 10-15°C.
- The cold temperature causes constriction of the blood vessels and limits post-injury swelling and accumulation of blood underneath the skin.
- This can also prevent potential tissue damage due to decreased oxygen flow in the injured area.
3Elevate the site of injury. This is especially helpful for extremities. Keeping the area in which the hematoma has occurred on an elevated surface will reduce blood flow to that specific area, minimizing swelling and keeping the hematoma from growing.[3] Use pillows or blankets to keep the area elevated.
- Keep the injured area above the level of the heart, if possible.
4Apply a warm compress after 24-48 hours. Use a heat pack or a washcloth soaked in warm water.[4] The compress should be 37-40 °C (98-104°F). In contrast with the cold compress, warm compress are more beneficial in the recovery stage, because they dilate the blood vessels and improve circulation and delivery of nutrients necessary for repair.
- The increased circulation caused by the warmth can help flush waste products from the injury, promoting faster healing.
- You may also find the warm sensation comforting if your injury is causing a lot of pain.
- Do not apply a warm compress immediately after the injury. Increased dilation of the blood vessels will do more harm early on.
- Hold the warm compress gently in place, and resist the urge to massage the area. Massaging can make the injury worse or dislodge a blood clot, which is potentially life-threatening.
5Do vasodilating activities after early onset of injury. Again, this is 24-48 hours after injury. Here's what you can do to heal the hematoma:
- Take a warm bath. Much like a warm compress, a relaxing warm bath will also soothe pain and improve circulation in the area.
- Do isometric exercises. This is basically contracting your muscles in the injured area without using a lot of movement. These types of contractions increase blood flow by rhythmically compressing the blood vessels.
6Take pain medication. If you are in pain, take some acetaminophen (Tylenol).[5] Do not take ibuprofen (Motrin) or aspirin, as these can prevent clotting and prolong your bleeding. Follow the dosage directions on the bottle.
7Use the RICE treatment to promote healing. RICE stands for Rest, Ice, Compress, Elevate. Rest the site of the injury as much as you can, and apply ice packs regularly during the first 48 hours after injury to reduce inflammation. When you are not icing it, gently compress the area by wrapping it in a compression bandage (not so tightly that you cut off circulation). Minimize swelling by elevating the injury above heart level (e.g., by lying in bed and propping the injured area up on a pillow).[6]
- Never massage a bruise or hematoma. This can cause a blood clot to dislodge and enter your bloodstream, which can be extremely dangerous.
Healing a Hematoma through Diet
1Eat more protein. This may provide needed benefits for tissue repair.[7] High levels of protein usually come from animal sources rather than plant sources. Here are some examples of healthy proteins that may promote healing:
- Whey protein
- Tuna
- Wild salmon
- Halibut
- Poached egg
- Turkey or chicken breast
- Cottage cheese
2Get enough vitamin B12. A vitamin B12 (Cobalamin) deficiency can also cause easy bruising, pernicious anemia, and poor blood clotting.[8] This is especially true for vegetarians — plant food sources have no vitamin B12 unless they are fortified. If you're vegan or vegetarian, it may be wise to take a supplement.
- B12 is found naturally in a wide variety of animal foods including organ meats (beef liver), shellfish (clams), meat, poultry, eggs, milk and other dairy foods, some breakfast cereals, and nutritional yeasts.
3Consume more vitamin C. Getting enough vitamin C is important for helping your body heal and repair damaged tissues. Eat a diet rich in vitamin C, and talk to your doctor about whether supplements may be helpful for you.[9]
- Great sources of vitamin C are papaya, bell peppers, broccoli, strawberries, pineapple, cauliflower and oranges.[10]
- As a rule, you can get enough vitamin C by eating a well-balanced diet. Supplements are only prescribed in special circumstances like malnutrition and pregnancy.
4Make sure you get sufficient vitamin K. Vitamin K deficiency is rare in adults. However, if you have it, it can result in impaired blood clotting and other bleeding problems, which can make hematomas worse. Vitamin K deficiency can be caused by certain antibiotics or medical conditions (such as celiac disease or cystic fibrosis). Talk to your doctor if you suspect you may have a vitamin K deficiency.[11]
- Sources of dietary vitamin K include green tea, leafy greens (such as Swiss chard, kale, parsley and spinach), broccoli and cauliflower, Brussels sprouts, liver, soybean oil and wheat bran.
- Fermented dairy, including yogurt, cheeses, and fermented soy, including miso and natto, provide menaquinone (vitamin K-2).
5Drink plenty of water. Staying hydrated can improve circulation and help your body heal after an injury.[12] The amount of water that's best for you will vary depending on your physical activity level, size, and overall health. In general, men should get about 15.5 cups (3.7 liters) a day, and women should drink 11.5 cups (2.7 liters) daily.[13]
- Water is better than any other liquid you can drink. Unsweetened fruit juices and decaffeinated teas are okay and can be consumed safely in moderation, but the focus should be water.
- It is possible to drink too much water, so don't force yourself to drink once your thirst has been quenched. Drinking too much can cause a dangerous electrolyte imbalance.
6Use turmeric in your cooking. Turmeric is a spice that has long been used in traditional medicine to reduce inflammation and promote healing.[14] It contains essential oils which can increase blood flow and the number of red blood cells. The hematoma can then be absorbed a lot more easily.
- Dissolve a teaspoon (5 ml) of turmeric powder in a glass of milk and drink the mix once a day. Alternatively, use it as a spice in dishes you cook at home. Use the remedy until the hematoma disappears.
- Turmeric is widely known to have medicinal properties, but there is not a lot of clear evidence to back it up. If you do use this remedy, be sure to supplement it with others.[15]
Understanding Your Condition
1Assess what type of hematoma you have. A hematoma is what happens when blood leaks outside of your blood vessels and pools under the skin or between 2 layers of body tissue.[16] There are numerous types of hematoma, which are called different things depending on where they occur. A few types of hematomas include:[17]
- Subdermal hematoma, found just beneath the skin.
- Cephalohematoma, a form of hematoma which occurs between the skull and the periosteum (the membrane covering the outside of the bones).
- Subungual hematoma, which can be found underneath a finger or toenail.
- Hematomas can also occur inside the abdominal cavity or between the skull and the lining of the brain. Internal hematomas caused by trauma or bleeding disorders may require medical treatment.
2Know the possible symptoms. Hematoma symptoms depend on the location and size of the hematoma. Here are the symptoms that often accompany your average hematoma:[18]
- Pain. Pain is one of the most common symptoms of a hematoma. It occurs because the tissue where the hematoma occurs is inflamed.
- Swelling. If a tissue becomes flooded with blood, it will become inflamed, and will eventually swell.
- Redness. Redness of the area where a hematoma is formed is caused by the blood building up underneath the surface of the skin (subdermal hematoma), and because of inflammation.
- Severe internal hematomas may cause more serious symptoms, such as headache and confusion, unconsciousness, or weakness in the extremities. If you experience any of these symptoms, seek medical attention immediately.
3Know the risk factors. One of the main causes of hematoma is trauma. For example, you may be prone to hematomas if you practice a contact sport, such as martial arts, boxing or rugby. However, there are other causes, too. Common risk factors for hematoma include:[19]
- Bleeding disorders, such as hemophilia and Von Willebrand's disease.
- Medications that affect blood coagulation, such as aspirin or warfarin.
- Deficiencies in certain vitamins, such as vitamin C, B12, or K.
- Age. Older people have thinner, more delicate skin, putting them at higher risk of developing bruises and hematomas.
4Know that surgery is an option. Certain hematomas require surgical intervention and drainage. Talk to your doctor about whether surgical treatment is right for you.
Community Q&A
QuestionWhat should I do if my hematoma is inflamed and swollen?Jonas DeMuro, MDDr. DeMuro is a Board Certified Pediatric Critical Care Surgeon in New York. He received his MD from Stony Brook University School of Medicine in 1996.
Critical Care SurgeonCritical Care SurgeonExpert AnswerWhen a hematoma has inflammation, and swelling as you describe, it raises the concern that it has become infected. This needs to be examined by a physician to be determined if it needs to be drained and treated with an antibiotic.
QuestionIf I have a hematoma and it burst and is healing, what is the white substance I have noticed?Jonas DeMuro, MDDr. DeMuro is a Board Certified Pediatric Critical Care Surgeon in New York. He received his MD from Stony Brook University School of Medicine in 1996.
Critical Care SurgeonCritical Care SurgeonExpert AnswerThe hematoma may have burst from a secondary infection. The white substance is most likely purulence from the infection. The wound should be assessed by a physician to determine if an antibiotic is needed, or if the wound should be debrided.
QuestionCan I fly within 24 hours of a leg hematoma?Marsha Durkin, RNMarsha Durkin is a Registered Nurse in Wisconsin. She received her Associates Degree in Nursing from Olney Central College in 1987.
Registered NurseRegistered NurseExpert AnswerAsk your doctor about whether it is okay to fly. It depends on the size and type of hematoma.
QuestionCan I apply warm compresses to a subdural hematoma that is 3 weeks old?Marsha Durkin, RNMarsha Durkin is a Registered Nurse in Wisconsin. She received her Associates Degree in Nursing from Olney Central College in 1987.
Registered NurseRegistered NurseExpert AnswerYes, after 48 hours you can apply a warm compress, but you should see a doctor if it is taking this long to heal. After 2 weeks a hematoma should be almost healed.
QuestionHow long does it take a large hematoma to heal?Community AnswerA large one can take around one and half months to heal and even then, the area may remain considerably swollen. Speak to your doctor for more tailored advice.
QuestionI sprained my ankle and developed a hematoma. How long willl it take to heal?Community AnswerAround a month. Keeping it elevated and regular hot and cold compresses will help speed the recovery.
QuestionIs it possible to get a hematoma in the center of a butt cheek?Community AnswerYes, it is. Applying pressure in short bursts may help it resolve more quickly.
QuestionI have a very large hematoma just above the pubic bone from my seat belt in a car accident. It is very hard, and the color is changing. Should I have my doctor look at it again?Community AnswerDefinitely. Although the hardness and scary colors are the normal progression of a healing hematoma, your doctor should order a scan to make sure it is not a pseudo-aneurism (a hematoma that is still linked to an artery). Also, he should treat you for the pain you're going to feel during healing and tell you what you can do at home to help blood re-assimilation.
QuestionCan I drive with a hematoma on my foot?Community AnswerNo, standard advice is to keep the leg elevated.
QuestionHow long will it take for the pain and swelling of a hematoma to subside?Community AnswerIt depends on the severity of your injury, but usually not more than a week.
I was headbutted on the lip and have had a small hematoma for a few years now. How do I get rid of it?
Can a hematoma be caused by the cuff of the blood pressure measuring device?
How do I treat a hematoma under my knee?
What can I do to heal a hematoma on my knee after having surgery?
How do I get rid of a hematoma in my leg?
- This article only applies to non-serious hematoma brought about by mild soft-tissue injury and is in no way meant as a substitute to professional medical care.
- Seek medical care immediately if pain from your hematoma suddenly increases, you experience a sudden increase in swelling at the injury site, or you notice numbness, pain, or lack of color in your limb below the hematoma.
- ↑ https://my.clevelandclinic.org/health/diseases/15235-bruises/management-and-treatment
- ↑ https://uncw.edu/healthservices/documents/InstructionSheet-BruiseandHematoma512.pdf
- ↑ https://uncw.edu/healthservices/documents/InstructionSheet-BruiseandHematoma512.pdf
- ↑ https://my.clevelandclinic.org/health/diseases/15235-bruises/management-and-treatment
- ↑ https://uncw.edu/healthservices/documents/InstructionSheet-BruiseandHematoma512.pdf
- ↑ https://share.upmc.com/2014/08/rice-method-for-treating-injury/
- ↑ https://my.clevelandclinic.org/health/articles/11111-nutrition-guidelines-to-improve-wound-healing
- ↑ https://my.clevelandclinic.org/health/diseases/15235-bruises
- ↑ https://medlineplus.gov/ency/article/002404.htm
- ↑ http://www.whfoods.com/genpage.php?tname=nutrient&dbid=109
- ↑ https://www.medicalnewstoday.com/articles/320394.php
- ↑ https://johnstonhealth.org/2012/03/5-tips-to-improve-blood-circulation/
- ↑ https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/water/art-20044256?pg=2
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/25200875
- ↑ http://www.simple-remedies.com/home-remedies/home-remedies-for-hematoma.html
- ↑ https://my.clevelandclinic.org/health/diseases/15235-bruises
- ↑ https://www.rxlist.com/hematoma/drugs-condition.htm
- ↑ http://www.nlm.nih.gov/medlineplus/ency/article/000713.htm
- ↑ https://my.clevelandclinic.org/health/diseases/15235-bruises
Article SummaryX
If you want to heal a hematoma at home, elevate the injury and move as little as possible for the first 48 hours so the bleeding stops sooner. Additionally, use a cold compress for the first 48 hours to reduce bleeding, then switch to a warm compress to speed up healing after the bleeding has stopped. After the first 48 hours, rhythmically tense the muscles in that area since that will increase blood flow and help you heal faster. Scroll down for advice from our Nurse reviewer on how to eat to heal a hematoma faster.
Article Info
Categories: Bruises
In other languages:
Español: curar un hematoma en casa, Italiano: Curare un Ematoma a Casa, Русский: лечить гематому в домашних условиях, Português: Curar um Hematoma em Casa, Deutsch: Ein Hämatom zuhause heilen, Français: soigner un hématome chez vous, Bahasa Indonesia: Menyembuhkan Hematoma di Rumah, Nederlands: Een milde hematoom zelf behandelen, العربية: علاج الورم الدموي في المنزل, 中文: 自己在家治疗血肿, Tiếng Việt: Điều trị khối máu tụ tại nhà, ไทย: ดูแลตัวเองเมื่อเกิดก้อนเลือดขัง, 한국어: 혈종 자가치료하는 방법


text:
In this day, we shall discussion of gorgeous pink rose bedroom for girl. Learn extra to discover fabulous pink and purple decorating ideas for teenage girl.
7 list of pink girl room for more beautiful girls bedroom that could seriously help. Elementary techniques could save you some lots of money down the road. Don't disregard to measure each and every here-discussed items.
Gorgeous Pink Rose Bedroom For GirlArticles :
Pink girl room for more ... ➦Posted on:
Thursday, 13 April 2017Category:


text:
cuartos oscuros en madrid. Hello beloved visitor. Hunting for unique thoughts is probably the interesting actions but it can be also exhausted when we can not discover the expected plan. Like you now, You are looking for innovative ideas concerning cuartos oscuros en madrid right?
Truly, we have been noticed that cuartos oscuros en madrid is being just about the most popular issue at this moment. So we tried to find some terrific cuartos oscuros en madrid graphic for your needs. Here you go. we found it from reliable on line resource and we enjoy it. We expect it deliver something new for cuartos oscuros en madrid niche. So, how about you? Can you love it too? Do you agree that this picture will probably be one of great reference for cuartos oscuros en madrid? Please leave a thoughts for us, we hope were able to give much more helpful information and facts for next reports.
This excellent cuartos oscuros en madrid image has published in [date] by admin. We thank you for your visit to our website. Make sure you get the information you are looking for. Do not forget to share and love our reference to help further develop our website.


text:
soap and glory sugar crush soap and glory sugar crush line.
soap n glory the righteous butter and sugar crush body scrub, sugar body scrub, soap glory and sugar crush moisture extreme body, my favourite scent soap and glory sugar crush range hill,soap glory sugar crush range review and photos fables in fashion , soap and glory sugar crush body scrub review helpless whilst drying, buy soap glory sugar crush body wash by trends n brands in, beauty soap glory righteous butter sugar crush review the, soap glory sugar crush moisturizer, sugar crush body scrub soap glory mecca.
Related Post
Leaky Tub Faucet Metal Airplane Decor Cheetah Wall Mount Toddler Water Table Sound Proof Board Target March Beauty Box Cooling Car Seat Dark Cherry Kitchen Cabinet Pallet Sofa Cushion Flip Flop Rug Heuchera Maxima Twin Bed Sheets Target Lisbon Cork Flooring 2014 Honda Civic Seat Covers Exterior Gfci Outlet


text:
left and right foot pegs for Yamaha PW50 PW80 footrest pedal PY50 PY60 motorcycle dirt bike pocket bike mini moto
*Pair for Motorcycle Footrests Pedals Foot Pegs Black Aluminium Pedal Pads
*High Quality Motocross Bike Racing Foot Pegs
*MX Racing Style Design
*Professional installation is recommended
*Material: Aluminium
*Color: Black(As Pictures Show)
*Fit for Yamaha TW200 PW50 PW80 Pit Dirt Bikes
*Fit for Honda CRF 50/ 70/ 80/ 100 Pit Dirt Bikes
*Fit for Honda XR50 XR70 Pit Dirt Bikes
Package Contents:
2*Pedals (left & right)2*Screws
Q1:If u can send me a sample ?
A:Yes, sure .But u will charge sample cost and freight .The sample cost will be returned after u place bulk order nex time .
A:Usually bubble bag ,white or brown box or blister card ,based on each items .
Q5 :What is the delivery time ?
A:Most our items are in stock now .Usually it is about 3-45days .It is depond on qty and items .
Q5:Do u test all product before shipping ?
A: we have QC team ,each items will be checked before shipping .
Q6:Do u reply our message on time ?
A: We will respond every message immediatelly between Chinese Time 07:00-23:00 ,also reply another time message next days .
Wuyi Hengying Chain Factory Found in 2010 years;we main supply dirt bike spare parts,pocket bike sparee parts,scooter bike spare parts and ATV spare parts for 14 years ,We have our own factory,our factory located on Jinhua City Of ZheJiang Province China;Meanwhile,we have professional engineer,we can custom design products according to the customers requriment;Our products sales all over the world,we have many regular customers in the world,they trust our products quality,we give them best price and fast service .Most parts are in stock now .Delivery time is usually about 1-7days for small order .