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The search for a magic bullet to kill only cancer cells has been on for years.
© Getty Images
New candidate cancer drug does damage only in tumours.
A new drug turns lethal only when it reaches cancer cells. In healthy cells it is harmless. Though not yet shown to work in humans, it is a step towards a magic bullet to knock out tumour cells selectively, with minimal side effects.
The drug works in mice implanted with human tumours, say chemists Lutz Tietze and colleagues at the University of Gottingen in Germany. Before being treated with the drug, the mice are given an enzyme to activate it that sticks only to the human tumour cells, ignoring healthy mouse cells. So the drug is safe until the enzyme activates it in the tumour. Then it destroys the cancerous cells1.
Magic bullet
Most existing chemotherapy is toxic to normal cells as well as cancerous ones. This causes severe side effects, such as a depressed immune system. Cancer researchers long for a magic bullet: a drug that works only where it is needed.
The warhead of the Gottingen antitumour molecule is a ring of three carbon atoms. This ring is highly strained and apt to burst open. Open, it is a reactive molecule that wreaks havoc among the nucleic acid molecules essential for normal cell function. The chemists copied this trick from a highly toxic antibiotic produced by a fungus.
So that their molecular bomb does not detonate everywhere in the body, the team have made a 'prodrug'. This is like the natural antibiotic but without the strained ring and with a sugar safety-catch. Once the sugar is clipped off, the molecule rearranges itself into a three-atom ring, and proceeds to do its toxic business.
Tietze's team uses an enzyme to cut away the sugar safety-catch. An antibody on the enzyme acts as a tumour-specific hook. Such antibodies linked to toxic or radioactive molecules have long been explored for making magic-bullet drugs; none has yet found clinical use.
The advantage of this enzyme-activated approach, originally developed in the 1980s, is that the drug isn't even activated until it reaches the target site. The selectivity of the damage still depends on antibody's ability to hook onto the right cells, and on the absence of other enzymes in the body that also activate the prodrug.
Whether the idea will work cleanly enough in humans remains to be seen.
PHILIP BALL | © Nature News Service
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The well-known representation of chemical elements is just one example of how objects can be arranged and classified
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Light can be used not only to measure materials' properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice "looks" in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth's gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.
The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....
Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.
Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...
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Do you experience allergy symptoms, but no allergy has been found? Are you quite sure that you are reacting to certain foods, but can't pin them down because you seem to be fine with the suspicious food one day, but react on another? Maybe it's not an allergy, maybe it's histamine intolerance. Not great if you've got it, but you may be able to do something about it.
When food causes pain
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Detroit Engine Diagram Intake System
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Sat, Jan 8, 2011 at 2:04 am CST
Dave Mann is a former editor of the Observer.
Get the latest Texas Observer news, analysis and investigations via Facebook, Twitter and our weekly newsletter.
Death Penalty Reform Bill Gets Watered Down to 'Nothing' Before Passing SenateAfter passing the House, HB 1139, meant to reform how Texas decides whether a defendant is too intellectually disabled to execute, was significantly softened in Senate committee.
With a Bizarre Assist by Democrats, Police Groups Kill Bill to Limit Arrests for Fine-Only OffensesA combination of incompetence and sabotage appears to have killed a police reform bill that had passed the House with an overwhelming bipartisan majority.


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Singer and song writer, Wizkid took centre stage alongside Canadian rapper, Drake at his 02 Concert in London.
Drake is currently on a world wide tour and so held the London leg of his show at 02 Arena, where he surprised fans by bringing out Wizkid.
YOU MAY LIKE: Wizkid teases fans about upcoming project
The artists performed their hit song for the first together "Come Closer" and also performed "Soco" together.
Wizkid just wrapped up his Canadian tour and also teased his fans with new music.
Share your thoughts below.
See post below:
Copyright © 2019 NaijaVibes. Permission to use quotations from this article is granted subject to appropriate credit being given to naijavibes.com as the source. Failure to do so, will invite take-down actions.


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Salted Pretzel Caramel Brownies-1 box Betty Crocker fudge brownies (for a 913 pan) 2 eggs…
Peanut Butter Chocolate Chip Muffins: a lot of protein, low sugar.
Chile Relleno
Lemon Sherbet you don't need an ice cream machine for : )
if i only had the skills to do this
100 calorie thin, light laughing cow wedge, marinara sauce, and loads of fresh spinach.
fresh strawberry mint lemonade
Nutella & Banana Wontons.
Easy Baked Tomato Pasta with Spinach. I gravitate toward anything with 'easy' in the title.
[recipe] kiwi lime sorbet from epicurious – so easy because you use frozen limeade concentrate
Key Lime Cake
French Toast Sugar Cookies.
Baked Mushrooms with LEGITIMATE recipe that would actually work. Trying it now. 🙂 Update: DELICIOUS!…
Chipotle's Cilantro Lime Rice
Cinnamon Roll Pancakes with Cream Cheese Frosting!


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Lisa's Blog
Making time to Relax!
Lisa Cutforth - Friday, May 15, 2009
With the busy lives we lead and the sense of time moving faster and faster and this increased efficiency of this modern world that allows us to do more and more, it is crucial to make time to relax: to SET ASIDE TIME to stop and just be! So, give yourself permission to take a break. Set aside some down time this week, schedule it in to your diary, especially all you executives, business owners, health care workers, mums and workaholics out there... stop... chill... for as long as you can. If you are worried that you don't have the time to do it, rest assured that the time off will leave you feeling refreshed and regenerated and ready to go, you will be much more motivated to get stuck in and get back into your work!
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Sankofa Adinkra: A symbol which symbolises going back one's heritage is a deep heritage concept from the Akan tribe in Ghana. The literal translation of the word is "going back for". Symbolised by a bird that reaches far back to… Continue Reading
Visual symbols created by the akan tribe of Ghana represent a traditional concept of thought and ideologies. Usually carved into wood, or woven fabric, in pottery and printed logos. The adinkra symbols are widely used in akan culture to emotions,… Continue Reading
It may be too late to get the perfect boyfriend the perfect gift, but with these ideas, you will be prepared for the next gift giving event in your blissful relationship. Continue Reading
Pull off the floral jumper look with red, an often underestimated look. This leaned towards cute look is a casual mix of the sensual autumn floral look and the bright red accessory and shoe that matches well in the white… Continue Reading
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steam generator by ganesh kumar pdf
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steam generator by ganesh kumar pdf - … steam generator by ganesh kumar pdf. ... gypsum powder production line machinery fuel coal pdf; business management ajanta clocks project ... The project site. Tags. Get A Free Quote. The 5 Biggest Project Management Trends Shaping 2018.
Experimental Investigation on Thermo-Electric Generator ...
Generator Used in Compression Ignition Engines G. Ganesh Kumar 1 1 Department of Mechanical Engineering, Kakatiya Institute Technology and Science, Warangal, Telangana - 506002, India
steam generator by ganesh kumar pdf
Ganesh Kumar Venayagamoorthy, Senior Member, IEEE a synchronous generator in a power system using a multilayer perceptron is the steam reheat time constant, is the pu shaft output ahead of reheater, and is the governor gain.
6th International Conference on Creep, Fatigue and Creep ...
Read the latest articles of Procedia Engineering at ScienceDirect.com, Elsevier's leading platform of peer-reviewed scholarly literature
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steam generator by ganesh kumar pdf
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Semi analytical analysis of steady state condition of steam generator Steam Steam Turbine(generator cooling ) Steam Generator Main Feed Pump Radial Bearing Modification ... :PDF ... From Boilersinfo.com Steam generator Ganesh kumar PREFACEDear friends,This book was prepared in view of giving assistance to designengineers entering ...
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In the modern industrial PDF created with pdfFactory trial version – 19.03 x Enthalphy of leaving gas) Enthalphy of leaving gas = 1.1 INTRODUCTION: The steam temperature above its saturation temperature corresponding to the pressure is achieved by introducing super heater coils.Steam generator Ganesh kumar Heat balance (heat lost ...
Development of Structural and Steam Generator Materials ...
Development of Structural and Steam Generator Materials for Sodium Cooled Fast Reactors.pdf. ... Ganesh Kumar J. ... The steam generator has been designed to operate for 30–40 years. It is ...
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Steam generator Ganesh kumar 2.0 STEAM,GAS and AIR 2.1 INTRODUCTION In steam generator water, steam, gas and air are the working fluids in this air and gas have similar properties. Understanding the properties of gas and air are almost one and the same.
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Unfired Steam Generators offered by Armstrong International Private Limited, a leading supplier of Steam Generators in Anjur, Chennai, Tamil Nadu. The Company was …
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MAXIMIZE BRAND VALUE. What we are doing is to give customers the most economical and suitable production line and maximize brand value. TCM is quite experienced in construction, milling and mining industry.
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Type IV cracking in modified 9Cr-1Mo steel Modified 9Cr-1Mo, ferritic-martensitic steel is selected for steam generator components in view of its virtual immunity to stress corrosion cracking in steam environment, and its good high temperature mechanical properties.
What is a combined cycle power plant? - Quora
A combined cycle power plant is one which is basically a gas based power plant. The exhaust of gas based plants are in very high temperatures which cannot be left as it is. Hence the heat of high temperature flue gas is extracted by a steam generator which produces steam.
steam generator by ganesh kumar pdf
steam generator by ganesh kumar pdf FREQUENCY REGULATION BY FREE GOVERNOR MODE OF OPERATION IN POWER STATIONS 3 If the generator is at a higher load denoted by the point 'F' and its load limiter is set at 'P L ', the rise in generation along the droop line will be limited to only 'P L ' and the operating point will only be 'L', whatever be
Ganesh Kumar Venayagamoorthy
Ganesh Kumar Venayagamoorthy Associate Professor of Electrical and Computer Engineering & Director of the Real-Time Power and Intelligent Systems Laboratory ... Synchronous Generator in Power System Using MLP/RBF Neural Networks" presented by the Industrial
REFERENCES - Shodhganga
Kim, D.H. "Nuclear steam generator level control by a neural network- tuning 2-DOF PID Controller", IEEE International Conference on Computational Intelligence for Measurement Systems and
Evaluation of variation of tensile strength across 316LN ...
Tensile strength variation across 316LN stainless steel fusion welded joint comprising of base metal, deposited weld metal and heat affected zone (HAZ) has been evaluated by Automated Ball Indentation (ABI) technique. Automated Ball Indentation tests were conducted on the various zones of the steel ...
CONSERVATION OF COAL BY INCORPARATING GEOTHERMAL STEAM IN BLAST FURNACE . Ganesh Kumar Tirumalasetty (. [email protected]) Graduate Trainee in Center for Structural & Chemical ...
Root Cause Identification and Elimination of Problems in ...
SSRG International Journal of Mechanical Engineering (SSRG-IJME) – volume1 issue5 September 2014 ISSN: 2348 – 8360 Page 20 Keep the cost of production of steam within Rs. 6/ton. Increase the power producing capacity of the plant to 10 MW/day.
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The Camco Gen-turi RV Generator Exhaust System is a venting system designed specifically for RV generators that provides for fresher air [More Info] RipRap - Company This plant was specially designed to provide aggregate producers with the widest, heavy-duty feeder in the industry for the ultimate portable plant in high production [More Info]
MODELLING OF DOUBLY FED INDUCTION GENERATOR CONNECTED WITH A WIND TURBINE GANESH KUMAR SUMAN (110EE0446) SUCHIT KUMAR SETHI (110EE0229) Department of Electrical Engineering
Steam Bath Equipment - Steam Room Enclosure Manufacturer ...
A Steam Bath opens pores, soothes sore muscles, increases circulation and provides a generally relaxing end healthy experience. Steam bath therapy causes body temperature to rise above its normal level bringing about a state of hyperthermia, or artificial fever.
International Congress on Advances in Nuclear Power Plants ...
with Steam Generator in Fast Reactor 490 T. Jayakumar, K. Laha, K. S. Chandravathi, P. Parameswaran, Sunil Goyal, J. Ganesh Kumar, M. D. Mathew (Indira Gandhi Centre for Atomic Research) 3.01 Liquid Sodium-Cooled Fast Reactors: Modeling and Design—II 12387 Conceptual Design Study of JSFR Reactor Building 500
Vol 4, No 3 (2017) - Edupedia Publications
International Journal of Research (IJR) invites the authors to submit their valuable presearch papers on the latest technology issues. It is an interdisciplinary journal and issued regularly every month.
A Literature Review on Failure of Long Retractable Soot Blower
steam flows out as a high velocity jet through the nozzles, ... M.Gowshikan, S.Ganesh Kumar, H.Surjith[6] The chemical recovery boiler utilizes the black liquor which is ... A Literature Review on Failure of Long Retractable Soot Blower (IJSRD/Vol. 5/Issue 10/2017/042)


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1kg or 2kg Pork Ribs to Share for Two or Four Including Onion Rings and Chips Each at Blacksteer Meadowdale
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Gourmet Ice Cream from R42 at Cold Gold Artisan Ice Cream & Sorbet
Choice of All-Day Breakfast for Two at Coffee Junction Cafe
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Raghunath Joshi (Type Director), Vinay SaynekarCopyright
2008 Microsoft Corporation. All rights reserved.Description
Tunga is an OpenType font for the Indic script - Kannada. It is based on Unicode, contains TrueType outlines and has been designed for use as a UI font.License
You may use this font to display and print content as permitted by the license terms for the product in which this font is included. You may only (i) embed this font in content as permitted by the embedding restrictions included in this font; and (ii) temporarily download this font to a printer or other output device to help print content.
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Ray LarabieAuthor
Ray LarabieTrademark
Numberpile is a trademark of Ray Larabie.Copyright
(c) 2002 Ray Larabie. See attached license agreement for more information. If EULA is missing, visit www.larabiefonts.com for an updated version of this font.Description
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Stefan Hattenbach, MAC RhinoAuthor
Stefan HattenbachTrademark
TaroccoOSF OT Medium is a trademark of Stefan Hattenbach, MAC Rhino.Copyright
Copyright (c) 2006 by Stefan Hattenbach, MAC Rhino. All rights reserved.Description
This software may only be used by registered PSY/OPS licenseholders. Visit psyops.com/licensing for information.
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Memos HandStyle
Luis Galv?nAuthor
Luis Galv?nTrademark
is a trademark of Luis Galv?n.Copyright
Copyright (c) 2012 by Luis Galv?n. All rights reserved.Description
Copyright (c) 2012 by Luis Galv?n. All rights reserved.
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1.00 October 6, 2005, initial releaseCopyright
Typeface (your company). 2005. All Rights ReservedDescription
This font was created using Font Creator 5.0 from High-Logic.com
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Harald GeislerAuthor
Harald GeislerTrademark
Prince and Princess Charming Princess Charming is a trademark of Harald Geisler.Copyright
Copyright (c) 2011 by Harald Geisler. All rights reserved.Description
Copyright (c) 2011 by . All rights reserved.
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Aviation PartnersAuthor
Nicholas GarnerCopyright
Copyright (c) 2010 by Aviation Partners. All rights reserved.Description
Copyright (c) 2010 by Aviation Partners. All rights reserved.
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Zing Diddly Doo ZappedStyle
1999; 1.1 www.stimuleyefonts.comTrademark
Arial Trademark of The Monotype Corporation plc registered in the US Pat & TM Off. and elsewhere.Copyright
Copyright (c) StimulEye Fonts, 1999. All rights reserved.Description
StimulEye Fonts http://www.stimuleyefonts.com email@example.com
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SF Baroquesque ExtendedStyle
Derek VogelpohlTrademark
SF Baroquesque Extended is a trademark of ShyFoundry.Copyright
Copyright (c) 2008 by ShyFoundry. All rights reserved. Freeware for personal use only. To purchase a commercial license, please visit our site at http://www.shyfoundry.com.Description
For additional information about the usage of this font, please read the included ShyFoundry Freeware EULA or visit our site at http://www.shyfoundry.com/licensing.License
For additional information about the usage of this font, please read the included ShyFoundry Freeware EULA or visit our site at http://www.shyfoundry.com/licensing.
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Oh JayStyle
Oh Jay ohjesus is a trademark of Dker.Copyright
Copyright (c) 2002 by Dker. All rights reserved.Description
Copyright (c) 2002 by Dker. All rights reserved.
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(URW)++ Design & DevelopmentAuthor
Joao Henrique LopesCopyright
Copyright 2012 by Joao Henrique Lopes, Digital Data Copyright 2012 (URW)++ Design & Development, GmbHDescription
Giureska is Gothic Sans typeface, a clear & readable blackletter. It has charm, power and sensuality. At the same time, it is simple and friendly.
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Jeremy DooleyAuthor
Jeremy DooleyTrademark
Coegit is a trademark of Jeremy Dooley.Copyright
Copyright (c) 2012 by Jeremy Dooley. All rights reserved.Description
Copyright (c) 2012 by Jeremy Dooley. All rights reserved.
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Tw Cen MT CondensedStyle
Monotype TypographyAuthor
Sol HessTrademark
Twentieth Century is a trademark of The Monotype Corporation which may be registered in certain jurisdictions.Copyright
Digitized data copyright The Monotype Corporation 1991-1997. All rights reserved. Twentieth Century is a trademark of The Monotype Corporation which may be registered in certain jurisdictions.Description
20th Century was designed and drawn by Sol Hess in the Lanston Monotype drawing office between 1936 and 1947. The first weights were added to the Monotype typeface library in 1959. This is a face based on geometric shapes which originated in Germany in the early 1920's and became an integral part of the Bauhaus movement of that time. Form and function became the key words, unnecessary decoration was scorned. This clean cut, sans serif with geometric shapes was most appropriate. The lighter weights can be used for text setting, the bold and condensed fonts are suitable for display in headlines and advertising.
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Robbie RocketpantsStyle
1.00 February 22, 2013, initial releaseCopyright
Typeface (your company). 2013. All Rights ReservedDescription
This font was created using FontCreator 5.5 from High-Logic.com
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Charles Borges de OliveiraAuthor
Charles Borges de Oliveira Borges LetteringTrademark
Desire is a trademark of Charles Borges de Oliveira.Copyright
Copyright (c) 2013 by Charles Borges de Oliveira. All rights reserved.Description
Copyright (c) 2013 by Charles Borges de Oliveira / Borges Lettering. All rights reserved.License
License Terms and ConditionsBorges Lettering End User License Agreement THIS IS A BINDING LEGAL AGREEMENT - Please read this Agreement before purchasing, downloading, installing or using the Font Software. Any of these actions shall indicate your express agreement to these terms and conditions. The Font Software licensed under this Agreement is licensed by Borges Lettering (?Author?). 1. GRANT OF LICENSE. This license to use the Font Software is non-exclusive, terminable and non-transferable and the use of the Fonts must be in accordance with the following terms and conditions. 2. PERMITTED INSTALLATIONS AND USES. 2.1 Installations. Use of the Borges Lettering Font Software is to the number of End Users identified when this License was purchased. The Font Software may be installed on not more than two (2) computers (workstation and laptop, iPad or other portable device used as a substitute for a workstation type computer for each licensed End User), provided that both computers are not used simultaneously. For the purposes of clarity, a Licensed End User may install the Font Software on their laptop, iPad or portable device and their workstation, provided both are not used at the same time. Serving of the Font Software to a Licensed End Users over a network, LAN, WAN or the Internet is strictly prohibited. If you need or otherwise desire to install and use the Font Software in such a manner, contact Borges Lettering for a special license. 2.2 Design Uses. Use of the Font Software in the creation of or as part of a company logo is permitted. Use of the Font Software in the creation of design works, rasterized images for web sites and for your personal use and professional use are each permitted provided that no unauthorized uses or copies of the Font Software are transferred to any unlicensed party. Other restrictions to the use of the Font Software are set forth in this Agreement. 2.3 One Font Software Back-Up. You are permitted to make a single back-up copy of the Font Software. The Borges Lettering Font Software or documentation may not be sublicensed, sold, leased, rented, lent, or given away to another person or entity. 2.4 Service Providers/Bureaus. In the event that you require the services of a third party for the production of color proofs, film or preparation for digital pre-press production or printing, upon completion of your job, the service provider must delete the Font Software or purchase their own license for continued use of the Font Software with other clients or projects it is hired to produce. 3. REFUNDS. If you do not agree to the terms of the Font Software License Agreement, do not download or install the Font Software. The Borges Lettering Font Software may be exchanged only if defective. If you do not agree to the terms of this Agreement and you wish to claim a refund you must (a) certify that no copy of the Fonts remains in your possession or control and (b) provide proof of a valid sale and a valid sales receipt. All claims must be made within one (1) week of purchase. 4. LIMITED EMBEDDING. You are permitted to embed or otherwise include only the Font outlines for PERSONAL, NON-PROFESSIONAL, NON-COMMERCIAL USE ONLY. Uses that are commercial or professional in nature, such as, but not limited to, multi-media CD, DVD, or other prohibited uses distributed physically or online require the purchase of a special license. 4.1 Software Embedding. The embedding or other use of the Fonts or the outlines thereof, in software or other works distributed electronically and/or via physical media for sale is prohibited under this License. Any such use requires the express written permission of Borges Lettering and may or may not require the purchase of a license upgrade at the sole discretion of Borges Lettering. 4.2 Flash Type Embedding. Use of the Font Software in Flash Type animations or otherwise embedding the outlines or designs embodied in the Font Software is expressly prohibited. Any such use requires the express written permission by Borges Lettering and may or may not require the purchase of a license upgrade at the sole discretion of Borges Lettering. 4.3 PDF Type Embedding. Professional users who have purchased a license in keeping with their actual uses are permitted to embed or otherwise include the outlines embodied in the Software in a PDF Type document, distributed physically or online for commercial use provided the Fonts cannot be extracted and the document is not for resale and that the Internet uses are not redistributions of otherwise impermissible or unlicensed uses of the Font Software. Resale of any document containing an embedded copy of the Font Software is prohibited and if the ability to sell documents and/or files containing embedded copies of the Fonts is desired, a license upgrade is required. Altering the embedding bits of the Font Software or otherwise Embedding the Font Software in PDF Type documents where the Font Software can be extracted from the PDF Type document is expressly prohibited. If you are unsure how to prevent font extraction, review your embedding software prior to creating documents containing embedded copies of the Font Software. 4.4. Webfont Embedding. This license does not permit the transmitting of the Font Software over the Internet for the purposes of font serving or font replacement by means of technologies such as, but not limited to, Cuf? EOT, sIFR or other technologies that now exist or may be developed in the future. Web Font Uses include but are not limited to serving the Font Software to remote viewers. If you wish to use the Font Software for such purposes, a special web font license must be purchase and is required. Translation or adaptation of the Font Software and/or serving translated Font Software to viewers on the Internet, such as, by of illustration only, via Cuf? WOFF, sIFR, TypeKit, embeddable Open Type, etc., is not permitted under this License. Any such use requires the purchase of a license upgrade. 5. RESTRICTIONS. Except as may be otherwise expressly permitted by your specific License, you may not distribute, sell, modify, include, adapt, translate, reverse engineer, decompile, disassemble, translate into other font formats or other formats for use with other forms of devices or otherwise copy and/or include the Borges Lettering Font Software or the design of the Font embodied therein without the express written consent of Borges Lettering. All rights not expressly granted are reserved to Borges Lettering and/or the Author. Any modifications, derivations and/or adaptations of the Font Software or the design embodied therein, requires the express permission of Borges Lettering which expressly reserves a right to create any such modifications, derivations or adaptations. This term is contractual in nature. 6. OTHER RESTRICTIONS. Use of Borges Lettering Font Software and the design of the Font embodied therein are not permitted in the following circumstances or applications without purchasing a license upgrade. In order to obtain a license upgrade, you must contact Borges Lettering at email@example.com for more information. If you are unsure whether your use of Borges Lettering Font Software is specifically permitted under this Agreement, contact Borges Lettering. a) ALPHABET OR LETTERFORM-RELATED PRODUCTS; PERSONALIZED PRODUCTS FOR RESALE OR IN LETTERFORM CREATION PRODUCTS OR DEVICES. b) BROADCAST ON TELEVISION CABLE OR THE INTERNET; COMMERCIAL EXHIBITION, OR FILM. c) EMBEDDING IN ELECTRONIC DEVICES; ALL GAMING DEVICES. d) EMBEDDING IN SOFTWARE e) LARGE VOLUME COMMERCIAL USES f) WEB FONT USES 6.1 Alphabet or Letterform Related Products for Resale. Letterform and Alphabet Products include, but are not limited to, scrapbooking uses involving reproductions of individual letterforms, including but not limited to, digital alphabets (Alphas); adhesive sticker alphabet products; embroidery letters or fonts, use in the creation of signage or numbering products; monogram products; rubber stamps; die-cut products, stencil products; tattoo flash, or converted into software or by other means for the pur
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Ray LarabieAuthor
Ray LarabieTrademark
Wintermute is a trademark of Ray Larabie.Copyright
(c) 2000 Ray Larabie. See attached license agreement for more information. If EULA is missing, visit www.larabiefonts.com for an updated version of this font.Description
To see more fonts by Ray Larabie, visit Typodermic.com and LarabieFonts.com
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Twelve Weeks PregnantStyle
David KerkhoffAuthor
David KerkhoffTrademark
Twelve Weeks Pregnant is a trademark of David Kerkhoff.Copyright
Copyright (c) 2010 by David Kerkhoff. All rights reserved.Description
Copyright (c) 2010 by David Kerkhoff. All rights reserved. Twelve Weeks Pregnant font is donationware. Please refer to the ReadMe file for FAQ and instructions. If no ReadMe file is present, this font was harvested by some bogus site. Please surf to dafont.com or fontspace.com for the original file.License
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Linotype GmbHAuthor
Hannes von DhrenTrademark
Klint is a trademark of Linotype Corp. and may be registered in certain jurisdictions in the name of Linotype Corp. or its licensee Linotype GmbH.Copyright
Copyright 2009 Linotype Corp., www.linotype.com. All rights reserved. This font software may not be reproduced, modified, disclosed or transferred without the express written approval of Linotype Corp. Klint is a trademark of Linotype Corp. and may be registered in certain jurisdictions in the name of Linotype Corp. or its licensee Linotype GmbH. This typeface is original artwork of Hannes von Dhren. The design may be protected in certain jurisdictions.Description
NOTIFICATION OF LICENSE AGREEMENTYou have obtained this font software either directly from Linotype GmbH or together with software distributed by one of Linotype's licensees.This font software is a valuable asset of Linotype GmbH. Unless you have entered into a specific license agreement granting you additional rights, your use of this font software is limited to your workstation for your own use. You may not copy or distribute this font software. If you have any questions regarding your license terms, please review the license agreement you received with the software.General license terms and usage rights can be viewed at www.linotype.com/license.Generelle Lizenzbedingungen und Nutzungsrechte finden Sie unter www.linotype.com/license.Pour plus d'informations concernant le contrat d'utilisation du logiciel de polices, veuillez consulter notre site web www.linotype.com/license.Linotype GmbH can be contacted at:Tel.: +49(0)6172 484-418
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1.00 October 27, 2013, initial releaseCopyright
Typeface (your company). 2013. All Rights ReservedDescription
This font was created using FontCreator 7.0 from High-Logic.com
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ParaType LtdAuthor
Manvel ShmavonyanTrademark
Vaccine is a trademark of ParaType, Inc.Copyright
Copyright 2013 ParaType Inc., ParaType Ltd. All rights reserved.License
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Amazing Spider-Man toile slantStyle
2.000 2011 initial releaseCompany
P. A. VannucciAuthor
P. A. VannucciTrademark
Amazing Spider-Man toile is a trademark of P. A. Vannucci.Copyright
Copyright (c) 2011 by P. A. Vannucci. All rights reserved.Description
Copyright (c) 2011 by P. A. Vannucci. All rights reserved.License
Freeware Font by Alphabet & Type (c) (R) 2011
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Rian Hughes / Device FontsAuthor
Rian HughesTrademark
Mercano Empire Lined Italic is a trademark of Rian Hughes / Device Fonts.Copyright
Copyright (c) 2002 by / Device Fonts. All rights reserved.Description
Copyright (c) 2002 by / Device Fonts. All rights reserved.
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Ray LarabieAuthor
Ray LarabieTrademark
Hybrea is a trademark of Typodermic FontsCopyright
Copyright (c) 2006 Typodermic Fonts. This font is not freely distributable. Visit typodermic.com for more info.Description
Please read the current Typodermic Fonts license agreement at http://www.typodermic.com/license.html
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1.00 December 12, 2012, initial releaseAuthor
Kirk SheltonCopyright
Typeface Kirk Shelton. 2012. All Rights ReservedDescription
This font was created using FontCreator 5.6 from High-Logic.com
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Jeremy DooleyAuthor
Le Havre is a trademark of Jeremy Dooley.Copyright
Copyright (c) 2008 by Jeremy Dooley. All rights reserved.Description
Copyright (c) 2008 by Jeremy Dooley. All rights reserved.
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Hannes von DoehrenAuthor
Hannes von DoehrenTrademark
Pluto is a trademark of Hannes von Doehren.Copyright
Copyright (c) 2011 by Hannes von Doehren. All rights reserved.Description
Copyright (c) 2011 by Hannes von Doehren. All rights reserved.
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Luciano VergaraAuthor
Luciano VergaraTrademark
Nordikka Black is a trademark of Luciano Vergara.Copyright
Copyright (c) 2015 by Luciano Vergara. All rights reserved.Description
Copyright (c) 2015 by Luciano Vergara. All rights reserved.
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Lanston Type Co.- P22 type foundryAuthor
Bruce Rogers, Colin KahnTrademark
LTC Fleurons Rogers is a trademark of Lanston Type Co.- P22 type foundry.Copyright
Copyright (c) Lanston Type Co.- P22 type foundry, 2005. All rights reserved.License
P22 End User License Agreement and Limited WarrantyThank you for purchasing P22 fonts. To ensure that P22 continues to bring you more exciting, historically relevant type, please take the time to read this agreement. It might not be the most fascinating read, but its very important and may answer many questions that you may have. Please register your fonts and remember that free software is an exception, not the rule. 1. Notice to user. You (End User) have not purchased the ownership rights to this font, but rather a license to use this font on a limited basis. Purchasing a license for any P22 font or font distributed by P22 (International House of Fonts, Sherwood Collection and other) via download, or e-mail, constitutes an agreement between P22 type foundry, Inc (P22) and the end user of the enclosed typefaces (software) that the terms and conditions of this contract will be followed. If the fonts are purchased in hard copy format (CD-ROM or floppy disk), removing the media from its protective sleeve (paper pouch, DVD cases, or other) in which the media is contained constitutes the same agreement. If you do not agree with the terms of this agreement, return the complete package with the CD or floppy disk sleeve unopened to the place of purchase. If downloaded or received by e-mail, all files must be deleted. A signed affidavit may be required to receive a refund.2. Grant of License. The basic P22 distributed software license is limited for use on a total of 5 devices at one site for use on a single platform. A device is defined as a computer, printer, character generator, server or any other machine that uses font data to rasterize letterforms. A site is defined as one physical location. Platform refers to operating systems designated as 'Macintosh', 'Windows' or other. A laptop may be one of the devices in the basic license of 5 devices as long as the laptop is associated primarily with the licensed location. Simply working offsite on a laptop is permissible in the basic license and is regarded as an extension of the site. Work transported from one distinct network to another distinct network, via a laptop requires each network to be licensed properly.Additional licensing is also required if you are installing the font(s) on more than 5 devices (Site License), or a LAN/WAN Server with more than 4 devices, or, if you and/or additional users will have access to the font(s) at more than one location (Corporate License), or, if your printer/service bureau is installing the fonts for job output for more than one-time use (Service Bureau). Upon completion of job, service bureau must delete the font software or purchase their own license.--To calculate the required additional license, call P22 at 716 885 4490 or visit: http://www.p22.com/licensing.html to receive a quote.One copy of the font software may be made for backup. You may transfer the original software to another party provided All materials, including back-up copies are transferred and that the recipient agrees to the licensing terms and conditions contained in this agreement, and all copies are removed from the originating end user's (your) devices. 3. Fair Use. The basic P22 license is intended to accommodate personal use as in the course of everyday correspondence and document writing, or in the design of self-promotion pieces like business cards, newsletters and brochures. Other uses designated as professional or commercial may require additional licensing.Professional use is work performed by, not limited to, freelance designers, small design firms and corporate advertising firms that incorporate P22 fonts within a design for a client or self-promotion. Most alphanumeric fonts are allowable without additional licensing provided that the Grant of License guidelines are met. However, the use of illustrative elements (also known as dingbats, extras, ornaments) within logo design requires an additional one-time license. If you have purchased the font(s) license for use on a large scale campaign such as in the course of entertainment promotion, advertising, corporate identity design, product packaging, store signage or in any way that requires the multi media (television, internet, print or other) output of the font(s), an additional license may be required. This applies to in-house or client based work. Call P22 at 716 885 4490 to receive your large scale campaign quote. A royalty based Commercial license is required when P22 font software is used to create a product sold for profit. If you have purchased the font(s) license for use as the principle design element to create a product to be sold such as, not limited to, rubberstamps, refrigerator magnets, or if the usage of the font adds value (value added) to a product to be sold such as wrist watches, house numbers, stencil kits, decals, digital art (screensavers, 3-D models, or other computer application), please call P22 at 716 885 4490 if you have any questions, for permission or to receive your commercial license quote or visit: http://www.p22.com/comlicensing.html for examples.The font may be modified if properly licensed for non-commercial or in-house use. The modified font software may not be sold or distributed.4. Font Embedding. The basic P22 license allows for the embedding of P22 fonts only if the document created is set to Print and Preview. If P22 fonts can be extracted, edited and therefore transferred in any way, an additional license is required to account for each recipient of the document and font file(s)5. Copyright. The software and accompanying documentation are copyrighted and contain intellectual property information protected by law. You may not make or distribute copies of this software or accompanying documentation without the express written consent of P22.6. Disclaimer and Limited Warranty. P22 warrants that the font software is free of errors and will be replaced within 90 days of purchase in the event of defective media. If failure of the font software results from accident, abuse, or neglect, P22 assumes no responsibility to replace the software. THE SOFTWARE AND ACCOMPANYING WRITTEN MATERIALS ARE PROVIDED AS IS, WITHOUT WARRANTY OF ANY KIND, EXPRESSED OR IMPLIED, AND P22 SPECIFICALLY DISCLAIMS THE WARRANTIES OF FITNESS FOR A PARTICULAR PURPOSE AND MERCHANTABILITY. IN ADDITION, P22 DOES NOT MAKE ANY REPRESENTATIONS REGARDING THE USE OR THE RESULTS OF THE USE OF THE SOFTWARE OR THE WRITTEN MATERIALS IN TERMS OF CORRECTNESS, ACCURACY, RELIABILITY, CURRENTNESS OR OTHERWISE. THE ENTIRE RISK AS A RESULT OF THE PERFORMANCE OF THE SOFTWARE IS ASSUMED BY THE USER.7. Update Policy. At the option of P22, there may be updated versions of the software which will be offered to registered users.8. Purchaser's Indemnity. You agree to inform any person (employee/co-employee/employer) having access to the P22 Software and copies thereof, of the terms and conditions of this Standard License Agreement and to ensure that these terms and conditions are abided. You agree to indemnify and hold P22 harmless from any and all claims, liabilities, and costs including attorney's fees, arising out of your breach of this agreement or promises you made. If these terms are not agreed to and respected P22 reserves the right to revoke Grant of License.9. Construction. This agreement is governed by and constructed in accordance with the laws of the State of New York. All disputes between P22 and the end user whether or not arising hereunder shall be conducted within the courts and jurisdiction of Erie County, New York.Please register your fonts. If you have purchased your font(s) directly from P22 you have been automatically registered. If you ordered your font from an authorized P22 reseller please keep a record of the time and place of the purchase; or if you purchased a CD, send in the reply/registration card enclosed within each package. (c)2004 P22 type foundry, Inc. -- Not Your Typical Type(tm) -- http://www.p22.com -- PO BOX 770 -- Buffalo, NY 14213
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Ray LarabieAuthor
Ray LarabieTrademark
Rexlia is a trademark of Typodermic FontsCopyright
Copyright (c) 2008 Typodermic Fonts. This font is not freely distributable. Visit typodermic.com for more info.Description
Please read the current Typodermic Fonts license agreement at http://www.typodermic.com/license.html


text:
As a native West Virginian, I am quite accustomed to seeing roadside stands advertising ramps upon spring's arrival.
I have only been cooking with ramps for a few years. I suppose my hesitation was due to the pungent reputation ramps have. It was enough for them not to be welcomed to the table.
However, I can recall Mr. Mike at 8th Street Confectionery in Fairmont, happily stuffing some inside of the Ramp Burger you can sometimes find on his special board in the spring.
Once I tried Mike's Ramp Burger, I was more than willing to experiment with them myself. This week, I have adapted a pesto recipe to include ramps rather than basil.
If you're not up to cooking, but still want to enjoy ramps before they are gone this season, you should head down to Elkins for the Ramps and Rails Festival this Saturday.
In addition to the many vendors who will be in attendance, the Durbin & Greenbrier Valley Railroad Company will be offering train rides that day. For more information visit: http://www.mountainrailwv.com/tour/ramps-rails/
16 oz. penne pasta
1 T kosher salt (for the pasta water)
1 bunch of ramps (roughly 6 oz., root ends trimmed, stalks and leaves cut in 1/4 slices (2 1/2 cups)
2 T butter
1/3 C olive oil
Salt & pepper TT
1/2 C walnuts, toasted
1/2 C Parmesan cheese, grated
1 T lemon juice
Preheat oven to 350 degrees Fahrenheit. Place the 1/2 cup of walnuts on a sheet pan and toast until fragrant, about 4-5 minutes.
Next, heat a large frying pan over medium-high heat and add the butter. As soon as the butter has melted, sauté the ramps for 2 to 3 minutes until they have wilted, stirring from time to time.
Transfer to a bowl and let cool to room temperature. Heat 4 quarts of water to a boil with 1 T kosher salt, add pasta and cook until al dente.
Reserve 1 C hot pasta water. Place the sautéed ramps in the bowl of a food processor. Add the lemon juice, toasted walnuts, parmesan, salt, olive oil, and process for about 1 to 2 minutes until the mixture forms a creamy paste, scraping the sides of the bowl once or twice.
In a large bowl, toss the cooked pasta with pesto, adding as much of the hot pasta water as necessary to make the pasta silky and saucy, not dry. Top with additional parmesan, if desired.