text:
New Research In
Physical Sciences
Social Sciences
Featured Portals
Articles by Topic
Biological Sciences
Featured Portals
Articles by Topic
- Agricultural Sciences
- Anthropology
- Applied Biological Sciences
- Biochemistry
- Biophysics and Computational Biology
- Cell Biology
- Developmental Biology
- Ecology
- Environmental Sciences
- Evolution
- Genetics
- Immunology and Inflammation
- Medical Sciences
- Microbiology
- Neuroscience
- Pharmacology
- Physiology
- Plant Biology
- Population Biology
- Psychological and Cognitive Sciences
- Sustainability Science
- Systems Biology
Water in protein structure prediction
Contributed by Peter G. Wolynes, December 4, 2003
Proteins have evolved to use water to help guide folding. A physically motivated, nonpairwise-additive model of water-mediated interactions added to a protein structure prediction Hamiltonian yields marked improvement in the quality of structure prediction for larger proteins. Free energy profile analysis suggests that long-range water-mediated potentials guide folding and smooth the underlying folding funnel. Analyzing simulation trajectories gives direct evidence that water-mediated interactions facilitate native-like packing of supersecondary structural elements. Long-range pairing of hydrophilic groups is an integral part of protein architecture. Specific water-mediated interactions are a universal feature of biomolecular recognition landscapes in both folding and binding.
Water is intimately involved in protein folding (1–4). That proteins denature both on heating and cooling strongly implicates the involvement of water degrees of freedom. Kauzmann (5) correctly inferred from thermodynamics the hydrophobic layering characteristic of protein structure before protein structures were determined crystallographically. The kinetics of water exclusion is often considered in discussing mechanisms of protein folding, but again it is the avoidance of water in the final folded structure that is emphasized (1). Hydrophobicity patterns have long been a dominant consideration in predicting protein structure by using sequence data (6) and are basic in synthetic protein design (7). Nevertheless, the structured character of water has not been a paramount factor in most existing algorithms for structure prediction (8). These usually rely on effective pair potentials (9) or buried surface area terms to account for the free energy of burying hydrophobic residues (10).
In this article, we hypothesize that specific water-mediated interactions help guide the folding process even before native contacts form. Using this idea we develop a bioinformatic, nonpairwise-additive interaction model accounting for water and show that it greatly improves the efficiency and accuracy of structure prediction for α-helical proteins. Analysis of folding trajectories with this potential strongly implicates the guiding role of long-range water-mediated interactions. Interestingly, we find here that long-range hydrophilic interactions, as distinct from hydrophobic interactions, also take center stage.
The bioinformatic route to water-mediated potentials is difficult in several ways (for more directly physical approaches see ref. 11). Although bound water is visible in structures, localizing waters is more difficult than localizing main-chain atoms. Monomeric protein structures also have relatively few visible water-mediated interactions. Our path to a water-mediated potential started with an energy landscape analysis of protein–protein interactions and a bioinformatic survey of interfaces in dimer structures (12, 13). We found that the often-used contact potentials (9) worked well to describe hydrophobic binding interfaces; however, hydrophilic interfaces were poorly recognized (13). This finding suggests that longer-range interresidue contacts, mediated by water, play an important role in stabilizing these interfaces (13). To test this hypothesis, we derived both direct and water-mediated binding potentials (13). When these two potentials were used simultaneously (13), smooth recognition of diverse binding interfaces was achieved (in contrast to the direct contact potential). Here, we show that water-mediated interactions play an important role not only in binding interfaces but in folding of monomeric proteins.
We use the associative memory (AM) Hamiltonian molecular dynamics model as a starting point (14–16). This Hamiltonian has two principal components: general polymer physics-based terms that are sequence independent, collectively called "backbone," and sequence-dependent knowledge-based distance-dependent additive potentials, collectively denoted as AM/C (AM/contact). The AM part describes interactions between all pairs of residues that are separated in sequence between 3 and 12 residues. It uses a set of nonhomologous memory proteins to build a funneled energy landscape by matching fragments. The C part applies to tertiary contacts between residues separated by >12 residues in sequence. All parameters in the potential have been optimized with a self-consistent procedure based on the energy landscape theory as described (15) (see Appendix: Computational Details and Supporting Text, which is published as supporting information on the PNAS web site).
The C part of the AM/C potential describes effective interactions between Cβ (Cα for Gly) atoms in each residue pair. It consists of three wells covering the 4.5- to 8.5-Å, 8.5- to 10.0-Å, and 10.0- to 15.0-Å distance intervals. Similarly, the potentials used in this study contain a first well for the 4.5- to 6.5-Å interval, whereas the second well is replaced by a local density-dependent potential (discussed below). They contain no third well, because it is unlikely that specific interresidue interactions are mediated by water to such a long distance (10–15 Å). There is also a residue-specific many-body burial profile potential describing coordination preferences of all 20 amino acids. The parameters for the resulting potential, which we call AM/W (W for water), were optimized by using our earlier sequence-based approach (13). We have further refined these parameters by using the self-consistent structurally based optimization scheme from energy landscape theory (15). We denote the original potential, AM/W-0, and the more refined one, AM/W-1 (see Appendix for Computational Details and Supporting Text).
For the coarse-grained models considered in our study, the definition of water-mediated contacts naturally becomes somewhat more indirect than, for example, in full-atom simulations. Because direct contacts are defined as occurring between residues that have a distance between Cβ (Cα for Gly) atoms of <6.5 Å, a similar constraint for water-mediated contacts places them in the 6.5- to 9.5-Å distance interval. A more extensive discussion of the rationale for this choice is given in ref. 13 where the results for protein binding recognition also was found to be robust with respect to various alternative definitions of water-mediated contact range.
To interact through water, we require that both residues are sufficiently exposed to water, or equivalently, neither residue should be buried in the protein interior (hydrophobic core). To model this we use a highly nonadditive local density-dependent potential: when either of the residues in the pair attains a local neighbor density above a critical threshold value (i.e., becomes buried), the potential switches smoothly but quickly from water mediated to protein mediated.
Results and Discussion
Physical Interpretation of the Interaction Potentials. Before discussing the simulation results, we briefly analyze the main qualitative differences between the AM/C and AM/W interaction potentials. The interactions within the range of the first well and the protein-mediated interactions of the second well of the AM/W potential are qualitatively similar to their corresponding AM/C counterparts (see Fig. 1 A and B ). The main difference lies in the interactions between hydrophilic residues in the second-well water-mediated interactions (see Fig. 1C ). Whereas very polar second-well interactions are destabilized on average for the AM/C potential, they are highly stabilized for the AM/W potential when two residues are in a low-density environment, i.e., when residues interact through water (Fig. 1C ).
Although these potentials are knowledge-based in origin, examining their details gives interesting physical insight into the nature of biomolecular forces (13). Perusing of charged residue interactions in Fig. 1 B and C suggests that a large desolvation penalty must be paid when a fully direct contact is formed, and, therefore, charged and highly polar residues prefer to avoid complete desolvation by interacting through one or two water layers. Even more interestingly, not only do oppositely charged residues attract each other when interacting through water, but so do residues of the same charge (Fig. 1C ). This finding either indicates that residues of the same charge alter their mutual pKa so only one residue is really charged (i.e., one has in fact a charged-polar interaction) or that correlated fluctuations of the counterion cloud (17) and the perturbation of the water hydrogen-bonding network bind the like-charged residues together.
General Trends. Given the differences among the potentials outlined above, we anticipate that the AM/W potential would significantly improve the AM/C potential results for those proteins that contain explicit water-bridged interactions in their native state. As we shall see, these water-mediated interactions also appear transiently during collapse and folding of the chain and help guide the heteropolymer into a correct topology. For each protein of 14 chosen for study (discussed below), we have carried out five distinct annealing runs (7.2 × 105 time steps) with each of the three potentials (AM/C, AM/W-0, and AM/W-1), starting from a randomly generated extended-coil conformation at high temperature (we have not optimized the annealing protocol for the AM/W potentials nor used other minimization techniques; ref. 18). For each run we have taken 240 snapshots at equal time intervals, monitoring the progress toward achieving a native-like conformation by using a contact overlap measure Q. Our Q measure is more stringent than the usual contact Q, because it takes into account not only the correctness of contacts that occur in the native structure but also the correctness of distances between all pairs of residues even when they are far apart in the native state. In addition to Q, when discussing various structures, we use other structural similarity measures, such as rms displacement (RMSD) and the combinatorial extension (CE) method, which makes sequence-independent alignment of two conformations (19). It is perhaps not surprising that comparing protein structures is a tricky business, involving several means of similarity as discussed (20).
The validation of any knowledge-based potential must be done on an unrelated set of test proteins because of the risk of parameter overlearning. Nine of the 14 α-helical proteins used are "training" proteins for the AM/C potential, i.e., they were used to derive the parameters for the AM and C parts of the potential (15). The W part of AM/W-0 was optimized by using a sequence-based technique for an unrelated set of proteins. Thus for the AM/W-0 tertiary contact potential these nine proteins serve partially as test proteins. On the other hand, the W part of the AM/W-1 potential was refined by using the same training set of nine proteins. We emphasize these relationships to be attentive to the possibility of overlearning. It is necessary to apply the potential to an unrelated set of test proteins for confirmation.
The performance of the AM/W potentials is well documented by five α-helical test proteins that we discuss in detail below (see also Supporting Text). Two test proteins [Protein Data Bank (PDB) codes 1BG8 (21) and 1JWE (22)] were targets taken from the CASP3 (Critical Assessment of Techniques for Protein Structure Prediction) event (ref. 20; a detailed compilation of all CASP results may be found at http://predictioncenter.llnl.gov), and three, target T0170 [PDB code 1H40 (23)], target T172b [PDB code 1N2X (24)], and target T129a [PDB code 1IZM (A. Galkin, E. Sarikaya, C. Lehmann, A. Howard, and O. Herzberg, personal communication)], were taken from the CASP5 event (http://predictioncenter.llnl.gov and ref. 25). Our results compare favorably with the top CASP predictions for these proteins (http://predictioncenter.llnl.gov), but have nevertheless been obtained a posteriori (although in a fairly automatic manner) and should not be regarded as new CASP entries. Nevertheless, because numerous prediction groups participated in CASP, the CASP experiment has generated valuable statistical data that may be used to calibrate progress.
When the best Q scores obtained for each protein during all five annealing runs are compared across all 14 proteins (Fig. 2), the following trends becomes evident. First, AM/C and AM/W potentials show similar performance for small (<115 residues) training proteins. As for small test proteins, 1BG8 (21) is greatly improved by both AM/W-0 and AM/W-1 potentials, whereas T0170 is improved only by AM/W-0. The most significant trend, one that is highly desirable, comes when the largest proteins (>115 residues) are considered. A methodical improvement in the prediction of both training and test proteins is achieved by both AM/W-0 and AM/W-1 potentials, the latter showing a more uniform trend (Fig. 2). For large proteins, an improvement of 0.05–0.10 in Q is very significant, typically improving global RMSD by a few Å and significantly improving other measures of fold recognition, such as CE Z score.
Specific Targets. Having achieved substantial progress in protein structure prediction by using the tertiary contact potential incorporating long-range water-mediated interactions, we next investigate the cause of the improved structural recognition. We focus on three proteins: (i) PDB code 2FHA (26), a training protein, the largest one in the protein set; (ii) PDB code 1BG8 (21), a small test protein for which both AM/W-0 and AM/W-1 show very significant improvements; and (iii) CASP5 target T129a (A. Galkin, E. Sarikaya, C. Lehmann, A. Howard, and O. Herzberg, personal communication), the largest test protein in the protein set, that has two interacting domains.
Human iron storage protein, ferritin [PDB code 2FHA (26)], is the largest protein studied (172 residues). Although it was a training protein for AM/C, there was a large improvement in structure prediction when using both AM/W-0 and AM/W-1 (Fig. 3A ). During the cooling schedule the divergence between the trajectories in nativeness occurs around T = 1.05. To further evaluate the difference between the potentials, we carried out free energy calculations as a function of Q by using the histogramming technique (16). These calculations show that the free energy minimum shifts toward more native-like structure for AM/W-0 vs. AM/C (data not shown). In addition, the thermodynamic energy as a function of Q (Fig. 3B ) indicates that AM/W-0 energy landscape is slightly more funneled than AM/C. The AM/C potential generates a rougher energy landscape than the AM/W potentials. This is even more exaggerated in the E(Q) plot of Fig. 3B caused by the statistical noise caused by slow exploration of deeper traps of the AM/C potential energy surface. These thermodynamic observations at least partially explain the improved prediction from the AM/W potentials.
The highest Q structure from AM/W-0 annealing is superimposed on the native ferritin structure in Fig. 3C . The CE structure alignment method gives a Z score of 5.7 for the alignment of 134 residues with an RMSD of 3.4 Å (a Z score >3.5 is considered as significant fold recognition). The first and last 15 residues were not aligned by CE, as evident in Fig. 3C . Because of this mispacking of these two relatively small fragments, the global RMSD of 10.2 Å turns out to be somewhat misleading. The distance plots for the native and the predicted structure (Fig. 3D ) indicate that the overall fold and the tertiary interactions are captured quite accurately. The best AM/C snapshot, on the other hand, describes correctly only a smaller part of the overall structure (118 residues are aligned with RMSD of 5.0 Å and Z score of 3.9). When we partition the Q-score data into native contacts that are short and medium range in sequence (between 3 and 12 residues) as opposed to long range in sequence (tertiary contacts, >12 residues), then the resulting Q short and Q medium are rather similar for AM/C and AM/W potentials (Qs = 0.74 and Qm = 0.59 vs. Qs = 0.79 and Qm = 0.64). The main performance gain comes from improved packing of supersecondary structural elements (Q long = 0.20 vs. Q long = 0.36). Although expected, because the AM potential describing short- and medium-range contacts is shared by all potentials, this finding directly shows that the AM/W potentials improve nativeness by better treatment of tertiary interactions.
The small test (CASP3) protein for which we have observed large enhancement in native structure recognition is Escherichia coli stress-response protein HdeA [PDB code 1BG8 (21)]. The superposition of best predicted structure with AM/W-1 and the native is shown in Fig. 4A . At the overall Q score of 0.47, the CE alignment of 70 residues of total 76 residues produces an RMSD of 4.2 Å and Z score of 3.7. The global RMSD was 5.1 Å. The best AM/C prediction (Fig. 4B ) again captures correctly large chunks of the structure (CE alignment of residues 7–62 produces a Z score of 3.3 and RMSD of 5.7 Å), but fails to pack them globally (overall Q = 0.31, global RMSD = 12.0 Å). Free energy calculations show that the minimum in F(Q) is shifted substantially toward the native for the AM/W potentials (Fig. 4C ), rationalizing annealing results.
Closer examination of the HdeA sequence reveals that both N- and C-terminal 11-residue fragments are highly charged (four charged residues in the N-terminal fragment and seven charged residues in the C-terminal fragment). Fig. 4B shows that it is these terminal fragments that are packed incorrectly by the AM/C potential. For analysis, we thus partitioned the protein into two fragments: a larger N-terminal fragment consisting of residues 1–61, and a smaller C-terminal terminal fragment consisting of residues 62–76. The annealing trajectories for the corresponding fragment Q scores (Fig. 4D ) indicate that AM/C and AM/W-1 produce qualitatively similar fragment structures down to T = 0.8, at which temperature the larger fragment experiences a jump in the nativeness for the AM/W-1 potential. This event is immediately preceded by a jump in the interfragment Q value (Fig. 4E ), suggesting that native interfragment interface formation nucleates the folding of the larger fragment. We have additionally partitioned the interfragment Q into first-well and second-well contributions (Fig. 4F ). This analysis shows the major improvement in the interface recognition comes from the second-well interactions. Because protein-mediated second-well interactions are greatly diminished in AM/W-1 (see Fig. 1C ) and we notice the charged nature of the C-terminal fragment (Fig. 4A ), we see that it is AM/W water-mediated interactions that greatly facilitate correct packing of secondary structure elements in HdeA.
When the HdeA crystal structure was originally published, Yang et al. (21) could not find any sequence or structural similarity to any other known protein. Its functional role was also unknown (21). In a subsequent study (27), it was demonstrated that HdeA provides acid resistance in bacterial pathogens (HdeA is stable under extreme acidic conditions). It was suggested that in neutral pH HdeA forms a dimer (the dimer interface is formed mainly by hydrophobic residues), which dissociates to become an active monomer when pH is significantly lowered (27), the exact mechanism of dissociation being unclear. Gajiwala and Burley (27) hypothesized that perhaps pH-induced conformational changes of unknown nature lead to dissociation. In light of our analysis, it indeed seems plausible that a change in the protonation state of terminal fragments would lead to large structural rearrangement, perhaps causing the dimer dissociation.
The final test protein for analysis is a two-domain CASP5 target, T129a [PDB code 1IZM; the structure has not been released at the time of writing (A. Galkin, E. Sarikaya, C. Lehmann, A. Howard, and O. Herzberg, personal communication)]. The distance plot comparing the best Q (0.36) predicted structure and the crystal structure (Fig. 5A ) shows that the major features of the protein fold are well captured (global RMSD was found at 8.7 Å). Interestingly enough, the same snapshot also has the best interdomain Q score for the same trajectory. However, there exist snapshots with somewhat better individual domain structures that are docked incorrectly (Fig. 5B ). The individual domain II Q scores between the best AM/C and AM/W-1 trajectories are of similar quality, but the AM/W-1 potential produces more native-like structures for domain I (Fig. 5C ). As in the case of HdeA, the interdomain Q (Fig. 5D ) shows the most improvement for AM/W-1 compared with AM/C. Partitioning the interdomain Q into first- and second-well contributions (Fig. 5 E and F ), again leads to the conclusion that water-mediated interactions enhance native-like packing of supersecondary structure elements.
At a coarse-grained level, the interplay between direct contact interactions and longer-range water-mediated interactions, both guiding the folding process, suggests some new protein physics. Direct contact potentials are crudely equivalent to surface tension between the protein and its solvent environment, whereas longer-range water-mediated interactions depend on the curvature of the protein–water interface. The complex solvation physics of polar and charged species in the presence of counterions shapes the curvature landscape. Our results imply that, at least in the cases studied, evolution has tuned both the surface tension and curvature contributions to be consistent with the principle of minimal frustration (28).
In summary, specific water-mediated interactions are a universal feature of biomolecular recognition, both in folding of monomers and binding of many dimers. We have shown that the inclusion of long-range water-mediated interactions, through a nonpairwise-additive switching potential, in structure prediction Hamiltonians leads to systematically improved predictions for protein structures. Detailed analysis of annealing trajectories for the model reveals explicitly that water-mediated interactions indeed help to correctly assemble supersecondary structure elements into the global native fold. We hope that the water model presented in this article will also help advance the important ongoing efforts toward building an accurate coarsegrained representation of water for self-assembly of both biological and nonbiological systems.
We thank Michael Prentiss for help with setting up CASP5 target calculations and useful discussions; Dr. Yaakov Levy for helpful comments when preparing the manuscript; Dr. Osnat Herzberg for giving us permission to show distance plots for CASP5 target T129a in Fig. 5 before publication of the crystallographic information; and W. M. Keek Foundation for providing access to computing resources at the W. M. Keek Laboratory for Integrated Biology. G.A.P. thanks the National Institutes of Health for its generous support of this work through a Postdoctoral Fellowship Award. J.U. thanks the Swedish Research Council and the San Diego Supercomputing Center for providing postdoctoral fellowships. The efforts of P.G.W. in concepts of protein folding are supported through National Institutes of Health Grant 5R01GM44557. Additional support was received from National Science Foundation Grants PHY-0216556 and PHY-0225630.
↵ †† To whom correspondence should be addressed. E-mail: pwolynes{at}ucsd.edu.
↵ ‡ G.A.P. and J.U. contributed equally to this work.
↵ § Present address: AstraZeneca R&D Mölndal, Drug Metabolism and Pharmakinetics and Bioanalytical Chemistry, SE-431 83 Mölndal, Sweden.
↵ ¶ Present address: D. E. Shaw Research and Development, 120 West 45th Street, New York, NY 10036.
Abbreviations: AM, associative memory; AM/C, AM/contact; AM/W, AM/water; RMSD, rms displacement; CE, combinatorial extension; PDB, Protein Data Bank; CASP, Critical Assessment of Techniques for Protein Structure Prediction.
See Commentary on page 3325.
- Copyright © 2004, The National Academy of Sciences
Cheung, M. S., Garcia, A. E. & Onuchic, J. N. (2002) Proc. Natl. Acad. Sci. USA 99 , 685-690. pmid:11805324
- ↵
- ↵
Eisenberg, D., Weiss, R. M. & Terwilliger, T. C. (1984) Proc. Natl. Acad. Sci. USA 81 , 140-144. pmid:6582470
DeGrado, W. F., Wasserman, Z. R. & Lear, J. D. (1989) Science 243 , 622-628. pmid:2464850
- ↵
- ↵
- ↵
Pertsemlidis, A., Soper, A. K., Sorenson, J. M. & Head-Gordon, T. (1999) Proc. Natl. Acad. Sci. USA 96 , 481-486. pmid:9892659
- ↵
- ↵
Friedrichs, M. S. & Wolynes, P. G. (1989) Science 246 , 371-373.
Hardin, C., Eastwood, M. P., Luthey-Schulten, Z. & Wolynes, P. G. (2000) Proc. Natl. Acad. Sci. USA 97 , 14235-14240. pmid:11114172
- ↵
Evans, D. F. & Wennerström, H. (1999) The Colloidal Domain Where Physics, Chemistry, Biology, and Technology Meet (Wiley, New York).
Wales, D. J. & Scheraga, H. A. (1999) Science 285 , 1368-1372. pmid:10464088
Shindyalov, I. N & Bourne, P. E. (1998) Protein Eng. 11 , 739-747. pmid:9796821
- ↵
- ↵
Weigelt, J., Brown, S. E., Miles, C. S., Dixon, N. E. & Otting, G. (1999) Struct. Fold. Design 7 , 681-690.
- ↵
- ↵
- ↵
- ↵
- ↵
Bryngelson, J. D. & Wolynes, P. G. (1987) Proc. Natl. Acad. Sci. USA 84 , 7524-7528. pmid:3478708
- ↵
- ↵
- ↵
- ↵
- ↵
Chang, I., Cieplak, M., Dima, R. I., Maritan, A. & Banavar, J. R. (2001) Proc. Natl. Acad. Sci. USA 98 , 14350-14355. pmid:11717394
Koretke, K. K., Luthey-Schulten, Z. & Wolynes, P. G. (1998) Proc. Natl. Acad. Sci. USA 95 , 2932-2937. pmid:9501193
Press, W. H., Teukolsky, S. A., Vetterling, W. T. & Flannery, B. P. (2002) Numerical Recipes in C++ (Cambridge Univ. Press, Cambridge, U.K.).
- ↵
Citation Manager Formats
Jump to section
You May Also be Interested in
More Articles of This Classification
Physical Sciences
Related Content
Cited by...
- Predictive energy landscapes for folding {alpha}-helical transmembrane proteins
- Frustration in the energy landscapes of multidomain protein misfolding
- Predictive energy landscapes for protein-protein association
- Genomics-aided structure prediction
- On the role of frustration in the energy landscapes of allosteric proteins
- Restriction versus guidance in protein structure prediction
- Quantitative criteria for native energetic heterogeneity influences in the prediction of protein folding kinetics
- Cooperativity, connectivity, and folding pathways of multidomain proteins
- Hierarchical organization of eglin c native state dynamics is shaped by competing direct and water-mediated interactions
- Effect of glycosylation on protein folding: A close look at thermodynamic stabilization
- Hydrophobicity of protein surfaces: Separating geometry from chemistry
- Consequences of localized frustration for the folding mechanism of the IM7 protein
- Localizing frustration in native proteins and protein assemblies
- Understanding ensemble protein folding at atomic detail
- High-resolution protein folding with a transferable potential
- Periplasmic Protein HdeA Exhibits Chaperone-like Activity Exclusively within Stomach pH Range by Transforming into Disordered Conformation
- Sparsely populated folding intermediates of the Fyn SH3 domain: Matching native-centric essential dynamics and experiment
- Domain swapping is a consequence of minimal frustration
- Water and proteins: A love-hate relationship


text:
Although Ecstasy declined in popularity after its introduction to the underground club scene in the 1980s and 1990s, a new generation of young users has discovered the drug. Many teens and young adults perceive Ecstasy as a non-addictive, relatively harmless psychedelic drug. However, Ecstasy can cause dangerous side effects, including nausea, vomiting, high blood pressure, dehydration, liver and kidney damage, an irregular heartbeat, and aggressive impulses.
Residential Treatment Centers are available for all patients—men, women or adolescents. With 24/7 support, patients can fully immerse in the recovery process with few distractions for the best outcomes. Length of stay varies based on individual need. After graduating from one of our therapeutic communities, treatment continues at an Outpatient facility best suited to each patient.
Even if you are aware of the harm that prolonged heavy drinking causes to the body, you will tend to believe that you would never let it get to that stage because you would be sure to stop long before then. But the truth is that drinking causes great harm to the body long before you can see the effects, and the most serious consequences might not be that far off. An idea of the extent of the negative health impacts of drinking can be seen in the NHS finances, which show that alcohol consumption is responsible for over 10% of the cost of healthcare in Britain. Beatings and addiction: Pakistan drug 'clinic' tortures patients
If you feel like you are ready to begin the transition process back into your "normal" routine but think that you might require further support, sober living is an option. It provides 24/7 accountability with check-ins, house meetings, regular meal times, therapy sessions and more but also provides the freedom to go out into the world and find positive employment and a supportive new home.
The action stage of change represents full recognition of a problem along with observable evidence of steps taken to reduce alcohol use. The clinician should reinforce and praise the decision to change. Emphasizing that the biggest error at this stage is to underestimate the amount of help needed to quit drinking is critical. The patient should be given a list of options for treatment including AA and pharmacotherapy. Eminem on drugs, addiction and rehab
Traditional alcohol treatment programs rely on evidence-based strategies such as psychotherapy, behavioral modification therapy, peer group counseling, nutritional counseling and 12-step programs. Rehabilitation begins with detox, a cleansing process that allows the patient to withdraw safely and comfortably from alcohol. After detox, the patient participates in a structured series of therapies that are designed to help him or her modify destructive behaviors and create a sober life. How to Stop Drinking Alcohol | Recovery 2.0 Protocol
As it gradually unfolds, drug addiction causes structural changes in the brain that distort thinking and perception, specifically in areas related to behavioral control, judgment, decision-making, learning, and memory. Drug addicts suffer enormously negative life consequences as a result of their compulsive and uncontrolled drug use, but that doesn't prevent them from returning to drugs again and again.
Completing a residential drug rehab program can be rewarding and healing, but without effective aftercare in place returning home presents the risk of falling into old habits. Aftercare provides the security and support needed to renew and reinforce the tools and techniques implemented at Searidge Drug Rehab. While the journey into the real world can be overwhelming; addiction recovery is a lifestyle change and commitment that simply does not end a month's time or so away at a residential drug rehab.
The specific medicines prescribed will vary depending upon your own particular experience of withdrawal and the symptoms you are manifesting, and it may be that certain medications will not be appropriate depending on your substance of abuse or your own personal health history; an experienced medical professional will be able to make those decisions to ensure you go through withdrawal as safely as possible.
According to the Addiction Center, moving into a sober living home after treatment is often the difference between going back to old habits or continuing on the path of sobriety. Sober living homes are not as rigorous as inpatient facilities. They are often secondary treatments used in conjunction with other programs, as opposed to primary options.
However, other elements – for example the type of therapies available – may lie completely beyond your understanding and experience. With this in mind, it is always advisable to speak with an addiction specialist who will almost certainly be able to think of things which may not occur to you but which could be very important. By leveraging the vast experience of an addiction specialist you can be sure that issues of great importance will not go unaddressed. First 24 Hours in Drug Rehab Treatment - 866-577-6868 - Ambrosia Drug Rehab Treatment Centers
The method that's proven to be most effective in treating alcohol addiction is to use medications alongside traditional behavioral therapy. However, medications are underutilized in alcohol addiction treatment, and many people are not even aware that they exist. Behavioral therapy involves individual or group counseling, and it equips addicts to overcome their addiction by giving them coping skills and addressing any other mental health needs.
What happens in the brain during alcohol withdrawal? GABA (gamma-aminobutyric acid) is the main calming neurotransmitter of the brain. GABA and adrenaline are supposed to be in balance during normal brain functioning. Frequent drinking causes the brain to produce less GABA, because the brain begins to rely on alcohol for part of its calming. So, frequent drinking causes your brain chemistry to be out of balance with an excess of adrenaline. When you suddenly stop drinking, your brain doesn't have enough GABA neurotransmitter to balance the excess of adrenaline, which causes withdrawal symptoms.
What kind of counseling and community service programs is available through the Treatment Center? Do they offer private, group, in-house, and outpatient (after-care) counseling services? How much is the family involved in the therapeutic process? What is the ratio of staff to patient load? Are all staff located onsite? How many beds does the Treatment Center contain? Is the Treatment Center a fully licensed facility through the state? Do all medical and counseling personnel hold credentials from nationally recognized schools? How does one pay for treatment received from an In-House Center?
SMART Recovery was founded by Joe Gerstein in 1994 by basing REBT as a foundation. It gives importance to the human agency in overcoming addiction and focuses on self-empowerment and self-reliance.[32] It does not subscribe to disease theory and powerlessness.[33] The group meetings involve open discussions, questioning decisions and forming corrective measures through assertive exercises. It does not involve a lifetime membership concept, but people can opt to attend meetings, and choose not to after gaining recovery. Objectives of the SMART Recovery programs are:[34]
Stimulants, such as tobacco, cocaine or prescription amphetamines, stimulate the brain and nervous system, causing increased alertness. Depressants, such as barbiturates and benzodiazepines, slow activity in the brain and nervous system, causing relaxation. Hallucinogens, such as LSD and PCP, drastically disrupt the way the brain and nervous system communicate, causing hallucinations.
Alcoholism treatment typically consists of a detox, followed by rehabilitation. Rehab programmes take place in either an inpatient or outpatient clinic, depending on your needs and circumstances. How severe your illness is, the length of time you have been addicted, and your personal situation will all play a role in what type of programme you choose.
To ensure that you feel as comfortable as possible on your journey to recovery, Priory offers a free drug addiction assessment with one of our addictions experts, allowing you to discuss your concerns in confidence, receive guidance on the next steps in the drug addiction treatment process, and begin to develop an understanding of the journey that you will be taking towards drug rehabilitation and recovery. You will also undergo a consultation with a consultant psychiatrist, who will gather information on your medical and psychiatric history and advise on future treatment. We are also able to offer a comprehensive medically assisted withdrawal detoxification process for your drug addiction, if this is required.
Outpatient treatment programs give you the flexibility to continue to live at home and work or attend school while participating in a program. There are varying levels of outpatient treatment depending on the level of care the patient needs. Some outpatient programs may involve several hours of therapy per day while others might require varying amounts of time throughout the week.5 Program requirements vary, and you can research the various programs to find what works best for you.
Illicit drug use poses risks for pregnant women and their babies. Drugs may contain impurities that can be harmful to an unborn baby. Pregnant women who use drugs may be more likely to harm the fetus with risky behaviors and poor nutrition. Drug use can lead to premature birth or low birth weight. It can also cause the baby to have withdrawal symptoms (sometimes in the form of neonatal abstinence syndrome), birth defects or learning and behavioral problems later in life.
Inpatient treatment, also referred to as residential treatment, provides clients with many benefits that other programs don't, whether they're struggling with drugs, alcohol or both. Because mental health issues often go hand in hand with addiction, The Recovery Village offers inpatient behavioral health treatment and inpatient substance abuse treatment together when needed. Some of the common co-occurring disorders include depression, anxiety and eating disorders. Inpatient care includes a number of programs designed to meet the physical and mental needs of men and women. When compared to outpatient treatment, inpatient care is more intensive, and with the many facilities throughout the country, there's a great chance you'll find an inpatient facility near you.
Many traditional alcohol rehab programs are based on the 12 steps and traditions that provide spiritual guidance through early recovery and beyond. Alternative or holistic addiction treatment programs may offer similar therapy and medical treatment that traditional programs provide, but expand to include complementary and alternative therapies like acupressure and acupuncture, yoga and meditation, and other practices. Religious-based alcohol programs also offer comprehensive medical and psychological treatment, but focus their group sessions and treatment philosophy on the teachings of a specific religious tradition or belief system.
Inpatient or residential treatment is the most intensive level of care, with round-the-clock monitoring and clinical management to alleviate withdrawal symptoms and provide structure. After the detox phase, the patient lives at the facility full-time while receiving therapy, group counseling, medication management, holistic therapies and other services. HOW TO HANDLE ALCOHOL ADDICTION | Motivational Video in Hindi
There are several differences between inpatient and outpatient care. Inpatient care is a more intense level of care than outpatient care, which is often a step down from inpatient care. Unlike inpatient care, outpatient treatment does not require clients to stay overnight. Clients can come to the facility regularly (daily, weekly, etc.) for a set number of hours a week, and go home after their session. This allows them to maintain their work schedule and tend to any other off-site responsibilities. Care is less intensive than the inpatient level, as clients typically no longer require round-the-clock care. Alcohol Rehab Florida
Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Doctor On Demand
Received income in an amount equal to or greater than $250 from: Blue Cross Blue Shield Federal Employee Program
Received royalty from Lippincott Williams & Wilkins for book editor; Received grant/research funds from National Alliance for Research in Schizophrenia and Depression for independent contractor; Received consulting fee from Blue Cross Blue Shield Association for consulting. for: Received book royalty from American Psychiatric Publishing Inc.
Disclaimer: Inclusion or omission of an organization or agency in this database does not imply endorsement or non-endorsement by canadadrugrehab.ca. In no event shall canadadrugrehab.ca be liable for any decision or action taken in reliance on information provided by this referral service. Any questions regarding an alcohol and drug rehab program listing should be directed to that organization. If you believe you need immediate assistance, call 911 or your local crisis line.
Alcohol addiction treatment at Priory is delivered as part of a comprehensive Addiction Treatment Programme. Our Addiction Treatment Programmes typically last for 28 days, and consist of you staying at one of our nationwide hospital sites on a residential basis, for the duration of this time. During treatment, you will have the opportunity to undergo a medically assisted withdrawal detoxification process if this is required, before undergoing intensive individual and group addiction therapy in order to address the source of your addictive behaviours, increase your self-awareness and take steps towards recovery. Whilst 28 days is the recommended treatment time for alcohol addiction, treatment lengths at Priory can be flexible according to your unique needs, requirements and commitments. The agony of opioid withdrawal — and what doctors should tell patients about it | Travis Rieder
Addiction is defined as a chronic, relapsing disorder characterized by compulsive drug seeking and use despite adverse consequences.† It is considered a brain disorder, because it involves functional changes to brain circuits involved in reward, stress, and self-control, and those changes may last a long time after a person has stopped taking drugs.11
If you or a loved one are seeking drug addiction treatment, there are resources available in every state. Finding a program that best suits your needs can be the first step toward lifelong recovery. The Recovery Village offers several full-service treatment centers in convenient locations throughout the country. Call today to learn more about treatment options and how the Recovery Village can help you find lasting healing.
According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), intervention meetings are different to more traditional alcoholism treatment programs. While this type of meeting is usually designed for a person who is on the cusp of developing an alcohol problem, they can also help motivate an alcoholic in to seeking more extensive treatment for their alcoholism. The best intervention meetings are usually those that both the alcoholic person and family can attend together. This allows the family to discuss how the individual's alcoholism has affected them as a unit. This is also a good setting for loved ones to strongly demand that the individual seek treatment, as they have the backup of professional counselors.
If you have any of these symptoms, your drinking may already be a cause for concern. The more symptoms you have, the more urgent the need for change. A health professional can conduct a formal assessment of your symptoms to see if an alcohol use disorder is present. For an online assessment of your drinking pattern, go to RethinkingDrinking.niaaa.nih.gov. Best Drug Rehab Florida - Addiction Treatment Center
Changes in the brain that support physical and psychological dependency on mind-altering substances are the direct cause of addiction, but those changes do not occur at random. Addiction experts believe drug addiction emerges from an interplay of genetic and environmental factors, although one factor or the other may be strong enough to make a person vulnerable to addiction in some instances. Best Drug Rehabilitation Manistee, MI 855-995-3815
For people living in poverty and those who are unemployed, even homeless, and struggling with the physical, emotional, and financial cost of addiction, the idea of entering a treatment program seems impossible because there is simply no money available. Because many treatment programs are beyond the ability of these individuals or their families to afford, some of them attempt a potentially dangerous cold-turkey or at-home detox, or other treatment methods that are not evidence-based. Some of these individuals, even though they want to move past their addictions, give up on the idea of rehab altogether simply based on the inability to pay.
Nicole Lee works as a paid consultant in the alcohol and other drug sector. She has previously been awarded grants by state and federal governments, NHMRC and other public funding bodies for alcohol and other drug research. She is a member and past President of the Australian Association for Cognitive and Behaviour Therapy. She is a registered Psychologist who has previously worked in private practice.
Some people are more vulnerable to drug addiction than others, just as some people are more vulnerable to cancer or diabetes than others. There is no single factor that controls whether you will become addicted. Overall, though, the more risk factors you have, the greater your chance of drug addiction is; on the other hand, the more protective factors you have the less risk of addiction you face.
The first step in treatment is brief intervention. The physician states unequivocally that the patient has a problem with alcohol and emphasizes that this determination stems from the consequences of alcohol in that patient's life, not from the quantity of alcohol consumed. Emphasizing the effects on family, friends, and occupation, as well as any physical manifestations, is important. Pointing out that loss of control and compulsive use indicate alcohol dependence also is important. Drugs & Addiction : How to Help Drug Addicts
The patient's response determines the physician's next step. If the patient denies the problem, recommending joining AA will not work. Involving the family and/or suggesting a trial of abstinence is useful, and, importantly, the physician should follow up with the patient in a few weeks. The patient might be angry initially and storm out of the office, but then the patient might recall the physician's warning months or years later and stop drinking. For patients who recognize a problem and will consider referral, the cheapest (free) and most accessible option is AA.
The first step in recovery is deciding if you have a problem. This can be difficult, because your addicted-self will try hard to convince you that you don't have a problem. This is where a trained professional can gently help. They can keep you from tricking yourself and prevent you from slipping back into denial. They are trained to look for signs of trouble.
Scholarships: Some organizations offer scholarships to help people with low incomes afford treatment. These scholarships are sometimes offered through private treatment facilities or through organizations concerned with helping those who are struggling with addiction. It is always advisable to inquire about scholarships or grants available for low-income individuals when seeking a treatment center. In some cases, SAMHSA also provides grants for treatment that can be provided through the state or treatment center. A Day in the Life of a Drug Addict *Emotional* (Part 2)

subset: commoncrawl


text:
To provide greater flexibility, there is an alternative route for meeting the minimum Excellent standard within Ene 01. Where four credits for 'Prediction of operational energy consumption' are achieved, the minimum standard for Excellent in Ene 01 can be deemed to be met, provided certain conditions have been met.
See section 4.1 of Guidance Note GN32, version 1.1 for further details.
This will be confirmed in the next reissue of the technical manual, but can be applied immediately in all issues of the UK NC2018 scheme


text:
By submitting this information, you provide express written consent to Romero & Co. - The Melcher Agency and our affiliates (the "Company") sending you future information, contacting you for telemarketing purposes using the information (including any phone numbers) you have or will provide us, and monitoring and recording these communications to assure the quality of service or for other reasons. This means the Company may contact you via residential number, mobile number and/or text messaging (including use of automated dialing equipment and pre-recorded calls). You are not required to give your consent as a condition of making a purchase with the Company. Additional information can be found in our Privacy Policy.
Want to see how long it takes to get to work from this property? Just enter in your work address and we will show you how long it takes to get there on every property you look at.
Absolutely stunning home in great , gated neighborhood, Diamond Ridge. Dramatic entryway with grand pillars and soaring ceilings. Formal Living/Dining room with a wet bar has stunning backyard views! The gourmet, island kitchen has tons of cabinet, solid surface counters and a sunny breakfast room. Custom built- ins too! Cozy Family room with a fireplace, more soaring vaulted ceilings, tons of window space and French doors to the patio. Flexible den or 4th bedroom. Spacious, bay window master suite has separate shower and tub, dual vanity and large walk-in closet. Plantation shutters throughout! Garage with loads of cabinets. Entertainers backyard with your resort style pool, nice grass play area and huge covered patio with tile and ceiling fans plus extended paver patios.
14038 S 34TH Street
Phoenix, AZ 85044
Added 24 Days Ago
3042 E DRY CREEK Road
Phoenix, AZ 85048
Added 4 Months Ago
Type anything you want here and we will see what we can find in the property descriptions. Maybe a name of a golf course you want to live by or a term like fixer upper.


text:
General Details About Vitamins For Acne
Pfizer voluntarily withdrew the popular anti-inflammatory drug Bextra from the market final month, and their inventory has suffered from both the loss of gross sales and the potential for a lot of product legal responsibility lawsuits. While the rationale for levitra best price its look within the youthful group of individuals is related to hormonal modifications, adults usually get it because of quite a lot of reasons which could extensively differ. Whatever the explanations could also be but the government has no alternative but to bell the cat now. It appears the federal government will not be critical about bringing suitable modifications within the IT Act, 2000 both as a consequence of absence of expertise or as a result of political causes. Regardless of what Nandan Nilekani and Indian authorities says, Aadhar challenge and UIDAI are serving a very vicious, evil and levitra best price nefarious objective of e-surveillance without procedural safeguards. Precise implementation of present Insurance policies and Legal guidelines is the most important hurdle before the Indian Authorities.
We help the Digital India project of Narendra Modi Authorities just like we supported the NeGP of Congress Government. Narendra Modi Government's push to membership Digital India with Aadhaar has additionally given rise to complicated and Constitutional Censorship and Surveillance points in India. Actually, Goggle web censorship has drastically elevated in the past. The truth is, as of 2008 there were over a hundred totally different firms making buy levitra generic Viagra, principally in India and China, but additionally elsewhere. Roman is one among a slew of new firms like Hims and levitra best price others shaking up the standard mannequin of healthcare by providing this sort of discount levitra online service targeted particularly at erectile dysfunction. The check accurately recognized 67 of the sixty eight microarrayed tumors, levitra best price with the discharge someone one tumor with practically a 50-50 cleft relating the 2 expressed genes upon which no analysis may very well be made. Genetic: particular genes are related to a higher danger of sure varieties of arthritis, similar to rheumatoid arthritis (RA), systemic lupus erythematousus (SLE) and ankylosing spondylitis.
Nonetheless, these days of chaos and non regulation are gone. Nonetheless, it's premature to foretell the longer term and efficacy of Digital India challenge at this stage as like National E-Governance Plan (NeGP) of Congress Government, even Digital India mission should be given a minimum of 5 years to work. We wouldn't have devoted laws for Privacy and Knowledge Protection (PDF) in India and Digital India may face troubles in future. Perry4Law Organisation (P4LO) has been providing its techno legal inputs, opinions and suggestions regarding Digital India project because the very inception. The fourth suggestion of P4LO and CEDILRI pertains to formulation of Nationwide Cyber Safety Coverage of India 2016 by Narendra Modi Authorities. The second suggestion of P4LO and CEDILRI pertains to Cyber Safety Infrastructure of India that needs urgent rejuvenation. The third suggestion of P4LO and CEDILRI pertains to formulation of Techno Authorized Policies concerning Cyber Safety and Nationwide Safety. The primary suggestion that P4LO and CEDILRI would supply to Indian Authorities is that the Digital India undertaking wants an pressing regulatory framework and adequate procedural safeguards in order that digital info and information are secure and safe.
Presently India is just not able to ensure Civil Liberties Safety in Cyberspace for Indian lots. That is more so when there are many individuals and establishments in India that are using Internet in an illegal method for promoting medical services and products. American authorities are afraid more counterfeits will discover their means into this nation, putting patients' lives at risk. One can find two humped camels in India only in Ladakh. As every part of e-governance is expounded to another one, a deficiency in the fundamental authorized and technological framework would carry unhappy outcomes for India. This leads to an incredible quantity of blood being pushed out of the guts to enhance blood circulation. Surprisingly, even Google is censoring results pertaining to Aadhar challenge and UIDAI and is messing up with search placement outcomes. Perhaps any individual at Google was already doing the pre screening of some net contents in India, with or with out knowledge of Google.


text:
Will the real Minaj please stand up? No, not you Nicki, you sit back down! We're talking about Kiki Minaj: the UK born, busty Jamaican temptress who'll have you so transfixed, you'll forget who that other "Minaj" even is! With a juicy set of 32E big fake tits and petite pussy lips, becoming a porn star was Kiki's destiny!

 A natural in the sack, Kiki is a milk-chocolate bowl of ebony delight who's got a real hankering for long white dick. Renown for her mastery of hard-charging anal, Kiki is one of the fiercest fucking babes England has ever bred. She's only got a few films under her belt, but getting a late start at 29 years-old, Kiki isn't wasting a single breath. You won't be seeing Kiki in any soft-core, girl-on-girl, candle-lighting romance anytime soon, because Ms. Minaj has only one gear and that gear is anal! And when she's not riding, she's shopping!

 Living a lavish lifestyle of epic proportions, Kiki makes it rain every time she walks into a shoe store. Stilettos, handbags, fur coats, you name it. Buying designer everything to go with her designer tits, this babe's got it all! But with how horny she is, you can rest assured Kiki would give it up in a heartbeat for one chance, just one, at a gonzo anal gangbang. So you'd better memorize the safe word, because when you've got this black beauty piston-ramming you deep into the night, there's no telling what kind of crazy action might unfold!
©2019 MG Premium Ltd. All Rights Reserved.
Trademarks owned by Licensing IP International S.à.r.l used under license by DigitalPlayground.com
All models appearing on this website are 18 years or older. Click here for records required pursuant to 18 U.S.C. 2257 Record Keeping Requirements Compliance Statement. By entering this site you swear that you are of legal age in your area to view adult material and that you wish to view such material. Please visit EPOCH.COM | WTS | SegPay, our designated E-ticket Supplier and Access Management Provider for digitalplayground.com. Please visit Vendo our authorized reseller.


text:
By Jeffrey Hoy
Date Added: 02/10/2018
I love them! They're very comfy and very stylish.
By Joel Moore
Date Added: 02/18/2018
I love these shoes. They are great for office wear and look very elegant and classy. Also they are very comfortable.
By Paula Johnson
Date Added: 09/12/2018
Bought two pairs of these shoes for myself in the past, and just purchased these for my sister for Birthday.
By Fred Carrillo
Date Added: 06/16/2018
I have these shoes in several colors. They are my favorite.
By Ronnie Gurley
Date Added: 06/12/2018
Style, comfort, year round use-it's perfect ! This shoe can go from work to night .
By Doris Schiefelbein
Date Added: 06/12/2018
it looks so elegant , i love the color and the design size fits great ..... sooooo comfortable!
By Sandra Widman
Date Added: 01/22/2018
love this shoe, stylish and Comfortable and I get a lot of compliments when I wear them with my leggings and my jeans.
By Mohammed Velasquez
Date Added: 07/06/2018
A Perfect fit , and I'm in love with it. I recommend it
Rated 4.6/5 based on 46 customer reviews


text:
Copyright 2019 Hubbard Radio Washington DC, LLC. All rights reserved. This website is not intended for users located within the European Economic Area.
a-pinch hit for Davis in the 7th. b-singled for Maile in the 9th.
1-ran for Smoak in the 10th.
LOB_Boston 8, Toronto 9. 2B_Bradley Jr. (5), Smoak (6), Drury 2 (10). HR_Devers (6), off Law; Betts (8), off Biagini; Chavis (10), off Cordero; Guerrero Jr. (5), off Porcello; Smoak (7), off Barnes; Tellez (9), off Hembree. RBIs_Betts (24), Moreland 2 (34), Bogaerts (32), Devers (27), Chavis (25), Guerrero Jr. (11), Smoak (22), Tellez (25), Maile (5), Jansen (10). SB_Betts (5). CS_Bogaerts (1).
Runners left in scoring position_Boston 5 (Bogaerts 3, Devers, Vazquez); Toronto 4 (Sogard 2, Drury 2). RISP_Boston 2 for 10; Toronto 2 for 6.
Runners moved up_Moreland 2, Leon, McKinney. GIDP_Moreland, Bradley Jr..
Insight by Carbon Black: Learn best practices for cyber threat hunting, compliance and cyber data analytics in this exclusive executive briefing.
DP_Toronto 2 (Sogard, Galvis, Smoak), (Galvis, Guerrero Jr., McKinney).
Inherited runners-scored_Cordero 1-0. HBP_Sanchez 2 (Bradley Jr.,Chavis). WP_Sanchez.
Umpires_Home, Roberto Ortiz; First, Stu Scheurwater; Second, Mark Wegner; Third, Alan Porter.
Copyright © 2019 The Associated Press. All rights reserved. This website is not intended for users located within the European Economic Area.


text:
A high quality binaural beat MP3 inspired by the brainwave patterns of Zen meditators. A deep ambiance of strings with opera tones can be heard. This MP3 is inspired by the work of Maxwell Cade and his research with experienced Zen meditators. Cade noticed that this pattern emerged after deeper Zen meditations, and so this is often called the "afterglow of meditation." Note: that this recording uses binaural beats. – headphones are required. Please remember to never listen to this music whilst driving or operating machinery of any kind.
Anabel has the empathic ability to sense the emotions of living beings and communicating with them, ever since she was little, possessing powers similar to Yellow of Pokémon Adventures. However, other characters do not seem to regard these as Psychic abilities, but rather a honed sense of empathy. Nevertheless, she is still portrayed as a sort of Psychic-type specialist. She also shares a strong bond with her Pokémon, calling them "my friend" upon sending them out. She failed to teach Ash and May her empathetic abilities, as their Pokémon receive nothing from them.
While it may not be a perfect therapeutic option for treating certain psychological conditions, brainwave entrainment is yet another tool that warrants further testing and exploration. There is clear evidence that certain protocols may benefit human performance. Unfortunately nearly all of the research has been conducted by those who clearly are affiliated with those who manufacture brainwave entrainment products.
Not only do certain brain wave rhythms get strengthened as a result of entrainment, but a dominant frequency band results in a different state of awareness. Those that have used a quality brainwave entrainment product can vouch for the fact that their perception is altered by their brain waves. Not only could this be due to brainwave changes, but it may be a result of increased interhemispheric communication.
Thanks Lorita. There hasn't been any isochronic tones research that I'm aware of, for anti-aging, fat loss or attracting people, or any significant anecdotal feedback. You could combine positive affirmations or hypnosis scripts with isochronic tones to try and change habits and that could help with fat loss or build confidence to attract people. But it would be the affirmations and hypnosis doing most of the work, the isochronic tones would just be used to help relax the listener and put them in a more suggestible state. I don't believe isochronic tones can affect those things, without being used in combination with some kind of vocal mental programming.
However, most of the frequencies at which the brain operates are too low for the ears to hear. This is where binaural beats come in. If you play a tone of, let's say 112Hz in one ear, and a tone of 100Hz in the other ear, your brain will "hear" the difference of 12Hz and entrain to that frequency. Continued exposure to a frequency of 12Hz will result in a state of non-drowsy relaxation accompanied by a decrease in mental chatter, nagging thoughts and worries.
While the physiological and psychological processes being uncovered by brain science in the study of brainwaves is sometimes complex and still being investigated, certain basic principles are well-established, easily understood, and helpful for achieving the most effectively use of brainwave entrainment when seeking relaxation, improved sleep, lowering of anxiety, or other goals. This important background information and scientific knowledge presented here includes:
Did you know that Past Life Regression can help you find your path to self discovery? People may explore a past life to help them gain an understanding of some of the issues that they are facing in this life. Oftentimes, there is a connection, a pattern of behavior, that has its roots in another time and in another place. If you are having trouble dealing with your everyday situation, The New York Hypnosis Center can help you. Through past life regression therapy you can address u…
Another effective way to release energy, frustration, and tension is to learn and practice a martial art. There are many to choose from: Krav Maga, karate, judo, tae kwon do, and more. In addition to keeping you active, martial arts have other benefits; they teach you self-discipline, and the self-defense techniques you learn can make you feel safer.
Nothing is more stressful than being unprepared. Get organized so you're ready for the next day, taking a few minutes to make a to-do list and clean up before you leave. Knowing you've got everything covered means you'll be less likely to fret about work in the evenings. When you come in the next morning, you'll have the sense that you're in control of the situation and can handle it. This sets a positive tone for the day, which can help you get more accomplished. (You can even turn your nightly beauty routine into a stress-relieving practice.)
On the other hand, natural bioidentical progesterone can be extracted from the wild yam. This is a little bit more complicated and expensive. However, the progesterone from wild yam does not cause the type of side-effects the progestin did. Plus, natural progesterone cream from the wild yam is vegan. Many companies will add vitamin E and other healthy fats that can be absorbed by the body. This benefits not only our hormonal health, but our heart and our whole body.
Deep relaxation is another major benefit resulting from the brains cortical frequency following response while using brainwave entrainment. As the brain tends to mimic the rate of frequency it is exposed to, thus allowing it to enter into that brainwave state, this helps explain why this technology can produce benefits commonly found with meditation.
After one month of using Equisync, I feel relaxed, calm and not stressed at all, despite that I am leaving my present job soon for an early retirement, I handle the situation very well. I have the feeling that I'm going to be ok and there is nothing to worry about. This is what I have gained so far from using Equisync and it's really meaningful in the erratic world that we live in.
Social interaction is your body's most evolved and surefire strategy for regulating the nervous system. Talking face-to-face with a relaxed and caring listener can help you quickly calm down and release tension. Although you can't always have a pal to lean on in the middle of a stressful situation, maintaining a network of close relationships is vital for your mental health. Between sensory-based stress relief and good listeners, you'll have your bases covered.
Thanks for the reply. I am now clearer on 'what' is heard. Can you expand or point me in direction ..a bit more about 'pitch frequency' and frequency spoken about and what exactly is the difference ..and how we use the higher pitch frequencies to 'hear' or become aware of them? Would you only pick up the low freq on a EEG?. sorry for being pedantic ..it still does not clear up split isochronics and possibly creating same situation as binaural beats..
Enter the matrix, and be awakened. Here is the code to DEEPLY relax and awaken your soul. Using Alpha isochronic tones and binaural beats (14 hz through to 12 Hz, 10 Hz and finally back up to 14 Hz), the music and pulsing beats and tones are produced to take you into a dream like, timeless state of mind. Time won't exist when you listen to this track. Track 1. Binaural beats. Track 2. Isochronic tones Track 3. Isochronic tones and binaural beats. Listen to Sample Track here.
After the illness, I returned to school and found out that I couldn't understand what the teacher was saying. Or what people were saying to me in general. Then I had difficulty comprehending math (which I was excellent at before). Then my reaction time just CRASHED. I was also classified by new teachers as "flighty", "in a dream world", "not mentally engaged", as my brain began to stay in a state of sleepy-but-unable-to-sleep mode.
Daniel Boone, in Kentucky, made his fortune trading ginseng, although he is remembered as a fur trader. It is reported in a book called Woodland Nuggets of Gold that George Washington wrote to Boone, "The war effort needs money, bring ginseng." American ginseng helped support the revolutionary war effort, and the most valuable cargo to leave New York by ship in that time period was in the Empress of China, which was carrying American ginseng to the Orient.
Applying brainwave entrainment in the alpha range may result in benefits similarly found with Zen or Transcendental Meditation. These benefits extend throughout the body and include improved breathing patterns, higher physical energy levels, an improved outlook, increased sports performance, improved relationships, and increased workplace satisfaction and performance … just to name a few.
Other entrainment methods sometimes used include autopan modulation that moves sound in an 180º arc to create a desired tone. Harmonic box entrainment, invented by James Mann, uses a layering of binaural and monaural tones that alternate between ears, requiring headphones. Sound modulation and filtering, amplitude modulation, and pitch panning use diverse sounds to create rhythmic pulses matched to the desired brainwave frequency.
While people have full control of themselves when they are conscious, it's a whole different ballgame when it comes to dealing with their subconscious. However, with regular production of Theta brainwaves, you're able to eliminate any emotional blockages you may have, allowing you to accept suggestions and ideas more, helping you re-program your brain to suit your needs.
Theta brainwaves are produced and associated with states of deep relaxation and meditation. They are also associated with the state of lucid dreaming and NREM sleep. In Theta creative inspiration and enhanced powers of visualization also come. The state of deep relaxation combined with the state where the mind is better attuned to absorbing knowledge, hence it brings the super learning state. Theta is incredibly good for stress relief and release too.
I have discussed these findings with my sister, and two nice which are professionals in the fields of psychology, and medicine respectively (my sister and older nice have vast experience on the psychology arena, and my younger nice is a pediatrician), and they all agree this therapy can be of a great benefit applied in conjunction with traditional self-improvement programs.
Basically, one frequency of sound plays through one speaker/headphone and a different sound frequency plays in the other speaker/headphone. With these two different frequencies playing in each ear separately, but at the same time, your brain automatically tries to make up the difference in this frequency range and therefore is gently brought into a new, desired brainwave state as described above. An example of this effect would be a 100Hz frequency playing in your left ear and a 105Hz frequency playing in your right ear. Your brain, over several minutes, distinguishes the slight difference in frequencies and automatically adjusts its brainwave state to match this difference – being 5Hz in this example and therefore putting your brainwave into a Theta state. Pretty cool huh?!
There's no doubt that brainwave entrainment audio is a great technology for anyone who is interested in encouraging altered states of consciousness and it certainly can help people to reach deeper states of relaxation than they might normally have access to. I myself will often listen to brainwave entrainment music in order to enhance my practice of meditation. But let's keep a balanced perspective, put all the marketing hype to one side for a moment and acknowledge that there is no brainwave entrainment technology in this world that can make you meditate like a Zen monk "at the touch of a button", despite what some might like you to believe. The mind is NOT a machine. It moves through various states of consciousness in an organic way and at a natural pace. We certainly can guide and accelerate that process with the use of brainwave entrainment audio, but we cannot control it with the same sort of specificity and immediacy as you might control the speed of the car you drive.
Disclaimer: Nothing contained on this Site is intended to provide health care advice. Should you have any health care-related questions, please call or see your physician or other health care provider. Consult your physician or health care provider before beginning the Hallelujah Diet as you would any other weight loss or weight maintenance program. Individual results may vary. Testimonials appearing on this website are received in various forms via a variety of submission methods. The testimonials reflect the real life experiences of individuals who used our products and/or services. However, individual results may vary. We do not claim, nor should the reader assume, that any individual experience recounted is typical or representative of what any other consumer might experience. Testimonials are not necessarily representative of what anyone else using our products and/or services may experience.
Targeted hemispheric changes: Some speculate that specific alterations in brain waves can be made on an individual basis. In other words, you can target one frequency in one hemisphere (via the right ear) and another distinct frequency in the other hemisphere (via the left ear). The left ear affects the right hemisphere and right ear affects the left hemisphere.
Progressive muscle relaxation is a two-step process in which you systematically tense and relax different muscle groups in the body. With regular practice, it gives you an intimate familiarity with what tension as well as complete relaxation feels like in different parts of the body. This can help you react to the first signs of the muscular tension that accompanies stress. And as your body relaxes, so will your mind.
You may not always be in the mood for meditation when your thoughts are racing, though it is a powerhouse of a stress reliever; you may sometimes face relationship stress that isn't as well-managed by breathing exercises (another highly effective stress reliever) as it might be by learning communication techniques. Guided imagery is fantastic for before bedtime while games are an optimal stress reliever to share with friends.
Many people suffer from insomnia and related sleep problems. Stress can disrupt the regular circadian (time-related) secretion of cortisol and can be a major cause of sleep problems. Cortisol normally obeys the body''s inner clock and responds to light and dark, morning and night. Cortisol levels are highest in the early morning, lower in the afternoon, and lowest at night. Cortisol helps to synchronize activity, patterns of eating, and patterns of sleeping.
However, black cohosh does come with some warnings. It should not be taken by women who are pregnant or breastfeeding. Women with estrogen-induced breast cancer or the risk of breast cancer, and those with liver issues, should not take black cohosh, as it has been found in some, but not all studies to exacerbate problems with breast cancer and liver disease.
I tried other companies the last few years or so….among the likes that mainly used binaural audio and the deepest I was really ever to achieve was alpha state….maybe theta once or twice over the last few years. It takes incredible dedication and practice to achieve the deep, renewing states of meditation that are most sought after…..I listened to the theta meditation mp3 last night and within what seemed like a few minutes my mind was flooded with imagery…memories long gone…my body was sleeping, heavy as lead, but my mind was crystal clear, aware of my surroundings. I could barely even open my eyes!
My name is ******. I'm a systems engineer which have worked on the engineering field for over 20 years. During the last few years I have faced some personal challenges which have put a lot of my abilities to a test. Over a year now I got the "Equisync II" CDs from the EOC Institute, and the results from the very beginning were really amazing. Even as an engineer it was not easy to understand the incredible benefits of this brainwaves therapy when used consistently.
You've heard the "om" sound yogis make when they meditate, right? Well, Joshi says using a buzzing sound is another way to use your voice to calm yourself in the midst of a freakout. "Bhramari, a humming bee sound, can be done by closing the eyes and making the humming sound like a bee," she says. "These sound vibrations calm down the thought waves and relax the entire nervous system. External sound frequency resonates with the internal rhythm of the body and mind, creating peace and tranquility within." Research from India has shown Bhramari to improve cardiovascular patterns. Press your ears closed for an even stronger vibration.
They are a useful and effective tool that allow you a structured means in which to entrain your brain into a desired, new brainwave state using an intended set frequency range of the audio track. Frequency ranges for desired sleep, recovery and deep meditation states to different/higher frequency ranges for performance "flow-states" and high-level focus and calculation.
A simple spinal twist can help you get a better night's sleep. It alleviates tension that's built up in your lower back throughout the day. Sitting on your bed with legs crossed, place your right hand down on the bed behind you and rest your left hand on your right knee. Sit up straight and inhale for four to eight counts, lengthening your spine as you breathe. On your exhale, begin to twist toward your right hand (don't strain your neck). Hold this position for four more full breaths, lengthening your spine on the inhales and deepening your twist on the exhales, if it feels comfortable. Repeat yoga asanas on opposite side. (These stress-reducing yoga poses also help calm anxiety.)
The studies included in the recent reviews of Tai Chi and yoga indicate that sessions between 60 and 90 minutes performed 2 to 3 days per week were effective in reducing stress and improving feelings of well-being (7,14,17). A study conducted in a worksite environment showed that 15 minutes of chair-based yoga postures was effective in reducing acute stress when assessed by self-report and with physiological measures (e.g., respiration rate and heart rate variability parameters). This finding indicates that shorter duration sessions can be effective in reducing acute stress with this type of exercise (15).
Our brains follow cues from outside stimuli, and brainwaves mimic the pulse rates of the sounds we expose it to. So, by creating tracks that pulse sound waves at a desired frequency, we can effectively coax our brain into that state. In layman's terms; by listening to some strange sounding brainwave frequency audios, we can literally slip our brain into a state of feeling calm, alert, focused, energized... and the list goes on. Pretty cool, right!?
This unique session works the opposite to most sessions. It attempts to 'dis-entrain' the brain, breaking stuck thinking patterns and allowing a fresh way of thinking. The recording contains random and chaotic isochronic tones spanning 7.83 to 18 Hz, played over a background of gamma-embedded noise. Use this session to sit back and allow fresh ideas and new connections to form. Finishes at the illuminating14Hz sensorimotor rhythm frequency.


text:
Elbow grease is an idiom for working hard at manual labour. It is a figure of speech for humorously indicating nothing else but manual work is required.
It is sometimes reported in the form of a snipe hunt, a prank where an apprentice or recruit is sent on an errand to retrieve "elbow grease" by his supervisor.
The practical joke consisting of sending someone for 'elbow grease' without explaining what it is, is commercialized by a company selling creams and lubricants falsely suggesting 'elbow grease' is the brand name while hiding any intended use. No description of what 'elbow grease' is is found on packaging or in its advertising, while the creams are intended for sexual use. This, however, is explained only in the 'about us' section of the commercial site


text:
Girlfriend? My nerdy, socially awkward brother who could never even talk to pretty girls suddenly has a girlfriend that he apparently spent the night with? american dad japanese girl porn wapdam xxx vedos sister and birather
tentatively at first, pushing more of Kenny into her slickened hole. alice hodges trailer https://inst74.ru/
sexvidwos Back at the Maximum Security Super-Villain Prison, a guard is walking down a long hallway. sexvdiofilme
lap, I think this girl gang bangli xxxmuve
marvi memon full fuckingvideo s red tub I didn't mean any of what I said. mugadha godse nude image erene hot sex xxxx
The hidden jars begin to explode, and now the edge of the tree line disappear in an angry red flame. humarxxx mugadha godse nude image
I think she will try to… erene hot sex xxxx ural-location
gang bangli xxxmuve I watched as Jessie put it on. xvideo suhgrat 1stngt
What a shameless harlot! And Marshall started really ramming it home into the nearly senior-citizens cunt. www hijra xxx
alice hodges trailer These questions and many more raced through my head as I got to my feet and left my bedroom. kapri sex american dad japanese girl porn
To have one of my most favorite people in the world excited by me was making me want to jump him. xvidoes com enimalz big fat naked women porn
If Phil didn't seal off this room from fucking, we would've interrupted a few unfortunate fuckers when we came in. sexx waptrick https://ruboard24.ru/
very young girls erotic foto Continue with a few long licks from the base of her sex all memek smp perawan di masukin kontol
hardcore blackpussypornvideos There. paint shop gay beeg
raveena full nude fucking image/ Mary smiled slyly, yes, she had kept tabs on him also. brazzars saxe muvi fat latring video eat
You could try dating, I suggested. anettedawnpussy hot pussy ass asian
Jill couldn't stop yawning over dinner, and wandered off toward the back of my house soon after. dfggh xxx https://colorise.ru
porno celine dion There is nothing more exciting to a woman than to know that her partner marvi memon full fuckingvideo s red tub
iranauntysex Want me to look at it for you, he suggests jokingly. ajithaxxc www masalacelips in
Kathryn says, I absolutely love it, thank you Crystal and thank you Crystal's Angel Daddy. sunny leone zonpron com foto meki sarah ardhelia
Then come join us, there's plenty of room. kapil romance xxx download foto ngentot gerak 18lincauknab
Elaine helped me clear the plates away and I walked her to the car to say our goodbyes. neha kakkar sex xxx via: mysteriumspb.ru
sleep porn redwap china 3gp Teagan rolled over, spooned up next to me, reached between her legs and guided me inside her again. mamta soni xxx
maharani college sex download Jenny78ph: Yes. frenchbibbottom60400 mujeres belles y desnudas y delgaditas
Then I saw that Prince Daniel was currently having his way with Princess Alexandra in the city square. mujeres belles y desnudas y delgaditas frenchbibbottom60400
Loading ...


text:
Privacy Policy
We respect your privacy, and are providing this notice to explain our online information practices. This notice applies to all information collected from or submitted to the Insurance Technology Association (ITA) website. Our website may contain links to other websites operated by third parties. ITA is not responsible for the privacy practices or policies of such third party websites.
We do not automatically collect personally identifiable information.
The website tracks certain information about visits to our website, such as the number and frequency of visitors to the site and its pages. These statistics are used internally only, to improve our site and for marketing purposes. The statistics may also be provided to third parties, but the information will not contain personal information nor can it be used to gather such information.
In some areas of our site, we may ask you to provide information that will enable us to verify whether you are entitled to access and use certain information, or to otherwise support your customer relationship with ITA, such as your address, telephone number and credit card information. ITA will never ask for your Social Security number. It is completely optional for you to participate. However, failure to participate may mean that you cannot access and use certain information, materials and services.
For example, we may request information from you when you:
1. Log-on to certain areas of our website, where you may be prompted to provide us with your user name and password as a condition to gaining access to certain information, materials or services
2. Register or sign-up to subscribe to a service
3. Subscribe to a newsletter or desire to be added to our mailing lists for other products or services
Under these circumstances, we will typically ask for your name, email address, phone number, address, applicable identification number or password that we may require, as well as other similar personal information that is needed to register or subscribe you to services or offers. On occasion, we may ask for additional information to enable us to provide you with access to and use of certain information, materials and services. In the case of mailed materials, you will be able to "unsubscribe" to these mailings at any time.
Our use of voluntarily-provided information
The personal information you voluntarily provide to us when using our website will be kept confidential. It also may be used to notify you of special offers, updated information and news. Agents or contractors of ITA who are given access to your personal information will be required to keep the information confidential and not use it for any other purpose than to carry out the services they are performing for ITA. Circumstances may arise where we are required to disclose your personal information to third parties for purposes other than to support your customer relationship with ITA. For example, disclosure may be required by law or the information may be pertinent to judicial or governmental investigations or proceedings.
How you may opt-out
We will send you information about our various products and services, or other products and services we feel may be of interest to you. Only ITA (or agents or contractors working on behalf of ITA and under confidentiality agreements) will send you these direct mailings. If you do not want to receive such mailings, simply tell us when you give us your personal information. At any time you can easily opt out of receiving further marketing from ITA by emailing us at firstname.lastname@example.com.
Security of information
To prevent unauthorized access, maintain data accuracy, and ensure the correct use of information, we have put in place appropriate physical, electronic, and managerial procedures to safeguard and secure the information we collect online.
Correcting your information
You can request a copy of the personally-identifiable information that ITA has collected about you via the Internet by contacting Jim Daggett at the address below. You can also have factual inaccuracies in this information corrected by contacting this same person.
Changes or modifications to this Policy
This Privacy Policy was last updated on Jan. 1, 2016. Any changes to the Privacy Policy will be posted on this website.
Contact Us
If you would like to contact us for any reason regarding our privacy practices, please write or email us at either of the following addresses:
Insurance Technology Association
Jim Daggett
12 Sterling Path
Yaphank, New York 11980
what is ita
ITA Mission Statement
The goal of the Insurance Technology Association is to provide members with opportunities to collaborate, educate, network, share, and use knowledge related to insurance technology. The ITA serves the insurance technology community as a resource and is dedicated to serving this specialized sector of the industry. Publications and educational programs created by the ITA are geared to professionals interested in or charged with evaluating, implementing, and marketing insurance-specific technology systems or services.
ITA publications
The May/June 2019 issue of ITA PRO magazine is now available in digital format! Just click on this link: http://www.itapro-digital.org/itapro/may_june_2019
In this issue, we recognize startup insurer Berkley One, the recipient of the prestigious ITA 2019 Bridge Award. Meet Craig Lowenthal, VP, Information Technology and Susan Vella, SVP of the Customer Experience Group, as they explain how technology and innovation are built into the very fabric of the company.
National Life Group realized that customer expectations were changing and took steps to transform their business to make customer interaction as smooth as possible. Their mission was to create a digital experience that ensured that their customers -- both agents and policyholders -- are delighted with National Life.
CIOs are being pressured daily to deliver dynamic and robust digital capabilities. It's one of the reasons Mutual Benefit Group decided to take one of its core applications -- claims -- to the cloud as a faster alternative to on-premises deployments.
Read more now!
online ita buyers' guide
Information on the ITA Pro Buyers' Guide, and how vendors can be a part of it
For more information, contact Jim Daggett at email@example.com


text:
uShip is an open marketplace where you can connect with feedback-rated service providers. Join uShip to see reviews about Equipment Transport Inc. and thousands of other transporters.
Equipment Transport Inc.
Find Jobs, No Matter What You Haul
With new shipments posted every 30 seconds, there's always money to be made on uShip.
Equipment Transport Inc.
Equipment Transport Inc. provides hauling services for a variety of equipment and cargo (also including permit loads). Our company uses lowboy and tail trailers.
View Equipment Transport Inc.'s Full Profile
Join uShip to get access to
Join uShip
Already have a uShip account?Sign In
How Does uShip Work?
Start by creating a listing with details about your shipment. Review and communicate with transporters as they submit competing quotes, then select and book.
Ready to Ship? Get Free Quotes


text:
Lots of people say that there is not enough time in the day for embroidery! I fall into that category as well, there just doesn't
new tutorial just uploaded – do you want to learn how to do appliqué manually and a little outside the box? How about using weld


text: (Willmar MN-) A pre-trial hearing takes place Wednesday afternoon for Steven Wood, the Willmar man accused of swindling charitable organizations around the country. Wood, 56, is charged with 6 felony counts of swindling and is currently free without bail. Court records say Wood would call various organizations, pretending to be an organization official, and would ask the organization to send him money from their coffers. Court records say the groups have sent him checks totaling nearly $13,000 up until this past January. A motorcycle group out of Oregon became suspicious and called Willmar police. Wood will appear before Judge Stephen Wentzel in Kandiyohi County District Court Wednesday at 1:15 p.m.


text:
Aluminium Guys
Project Info
Category: Door Designs Aluminium Lounge
Date: June 20, 2019
Site URL: aluminiumguys.co.za
Project Description
VELFAC Ribo entrance doors. Window Design Ideas. Origin Front Doors for Added Security. Painting Glazed Interior Doors with Simple DIY Method. Gorgeous kitchen lounge with corner sliding door. Spitfire S 500 Series Beautifully Engineered Aluminium. Pivot Doors. Architect Series Sliding French Patio Doors. Fancy Aluminium Entrance Doors 91 On Wow Interior Decor. Aluminium Guys


text:
Expires: Mon, 17 Jun 2019 23:40:13 GMT
Date: Mon, 17 Jun 2019 22:40:13 GMT
Last-modified: Wed, 06 Jun 2014 16:06:06 PDT
Content-Type: text/html; charset=ISO-8859-1
Proofs, uncirculated, and cameo U.S. coins.To all customers: FREE SHIPPING on purchases totalling $200.00 or more in this category. To customers using Paypal: Log on to Paypal.com and send payment to goodfaithchapel.. To customers paying by check or money order: Make payable to "International Interfaith Ministries" (do NOT use the store name in the Payee field), and mail to International Interfaith Ministries at P.O. Box 750, Seaford, DE, 19973
To order an item from Art, Artifacts, Antiques, Books, and Collectibles, just click on the 'Add to Cart' button.
Clicking on the thumbnail picture of any item gives you a larger picture of that item.
Thanks for shopping at Art, Artifacts, Antiques, Books, and Collectibles!
Art, Artifacts, Antiques, Books, and Collectibles
Contact us!
2020 Pennsylvania Ave. #777Washington, DC 20006United States
Updated Monday, June 17 2019Product descriptions copyright© 2019 Art, Artifacts, Antiques, Books, and CollectiblesAll else copyright© 1995-2019 TIAS.com All rights reserved.


text:
Adam Bulger
More From Adam Bulger
What I Learned About Marriage From My Parents' Divorce Being the child of divorce can have a lot impact. Here, five married adults discuss how their parents' split affected their marriages.
Love & Money
"I Couldn't Believe It": 7 Parents Share Their Daycare Horror Stories We asked a variety of parents to share their worst daycare experiences. They did not disappoint.
Love & Money
Forget the Sunday Scaries. Parents Worry About the Weekend Modern parenting can often be so daunting that the routine of work feels like a respite.
Never Hide Your Debts Lies about secret accounts and credit cards are destroying marriages at an alarming rate.
These Photos of Parents Before and After Kids Show a Hilarious Vision of What's to Come The "Got Toddlered" Instagram account posts photos of parents pre- and post-kids. It's a hilarious, unfiltered reminder of the stark reality of parenthood.
Is the Baby Gear Rental Industry B.S.? More companies are renting bassinets, cribs, and other such baby gear to parents. Is it a smart move to rent your nursery or does the math not add up?
Easier, Cheaper, Faster: Welcome to the New World of Online Divorce A new crop of companies are making divorce easier and more affordable than ever. But that doesn't mean that the process is any easier.
Love & Money
Could Open Marriages Save Monogamy? Open marriage is becoming more of an option for couples. For many, it's the solution to many of their issues. Therapists know why.
Love & Money
Why Won't My Wife Stop Futzing With Me In Public? Some people can't help but fuss over their spouse's appearance. But why does the act provoke such rage? And why are some of us so compelled to do it anyway?
Love & Money
What Does a Modern Midlife Crisis Look Like? No, the midlife crisis isn't an actual phenomenon that strikes everyone. But that doesn't mean 40 comes with a whisper.
Social Media Is Making Cheaters Out of Us Extended time on social media makes it easier to escape into the lives of others — and find solace in former flames.
Love & Money
Is CBD the Secret to Being a Chill Dad? It's touted as anxiety-reducing and pain-relieving without the weed-induced impairment. Of course dads are getting on board. But is it worth the hype?
How to Have the Best Quickie Sex of Your Life The quickie offers a much-needed opportunity to relieve stress, strengthen a relationship, and get off at a time when intimacy, connection, and, well, time, are luxuries.
Love & Money
Self-Improvement For New Parents Is a Trash Idea It's easy to not focus on improving yourself when you're a parent. It feels selfish. And time and energy are low commodities. But it can — and should — be done.
Love & Money
Show More


text:
Update my wedding date
We will pass this information to Kenny Hickey Photography so they can respond. Hitched will create an account for you to view your suppliers in a list and create a free wedding plan.
Immediate Media Company Limited would love to send you the Hitched newsletter and wedding offers. You can unsubscribe at any time.
Your data will be used in accordance with our privacy policy
I am a highly experienced and creative wedding photographer based in Kent. Please see my very 'Special Offer'for Hitched users only by clicking on the Special Offertab.
I shoot contemporary and more traditional weddings across the UK and can cater for all types and tastes. I always take the upmost care with every image, which I post-produce personally at the editing stage. I document all types of weddings from registry offices to venues such as Hever Castle, Chiddingstone Castle and National Maritime Museum where I was honoured with the very prestigeous postion of Head of Photography for several years. I have spent many years photographing the Royal Family including around 30 private appointments with HRH Her Majesty The Queen. I also work with a second photographer at no extra cost to ensure maximum coverage on your special day. Please visit my website for more detailed information..Best Wishes ..Kenny
From: Gemma
To: email@example.com
Subject: FW: Hever Castle 03-08-13
Date: Sun, 25 Aug 2013 16:56:28 +0000
Hi Kenny
We just wanted to say a huge thank you for being our wedding photographer at Hever Castle on 3rd August.
I'm sure all your clients tell you the same but we really did have the most wonderful day from start to finish.
I still cannot quite believe I was fortunate enough to have the fairytale wedding I always dreamed of but finally
we got there & thanks to you we will cherish those memories forever.
Thank you so much for the fab taster of pics you sent, they are simply amazing and something I looked at over and
over again while on honeymoon. I don't normally like looking at pictures of myself but somehow these are just so beautiful.
You are a very talented photographer and I am so pleased we chose you to capture these precious moments.
My guests all commented on how tirelessly you and your assistant worked on the wedding day, yet how calm and relaxed
the atmosphere was. You clearly love your job and it shows through your pictures.
We are very much looking forward to seeing some more of your wonderful work.
Best wishes
Gemma & Neil Henson x
Rick Bauer commented on Kenny Hickey Photography's Amy & Paul's wedding at Hever Castle album.
Hever Castle 12th August 2013
Rick wrote: "Kenny, you are the consummate professional.
Your work and talents and your creative vision are beyond compare.
We feel so fortunate to have worked with you at Amy and Paul's wedding.
You cannot imagine the number of comments that we have received on just the initial batch of photos.
Your skills are beyond anything that I have experienced. Thank you, again… You are the best!"
Rick & Rosemarie Bauer
Our trusted network of suppliers and venues we have worked with
Kenny Hickey Photography details have been saved to your shortlist.