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Kaiut Yoga, a yoga of Biomechanics, serves the modern body and modern mind, to increase freedom of movement, working from the joints to maintain/return the body to an optimal structure and function allowing the internal systems to function as efficiently as possible, for as long as possible. This is for every body no matter your shape or flexibility.
Monday, July 15 at 9:00am to 10:00am
More dates through September 1, 2019
Tuesday, July 16 at 5:30pm to 6:30pm
Wednesday, July 17 at 9:00am to 10:00am
Thursday, July 18 at 5:30pm to 6:30pm
Saturday, July 20 at 9:00am to 10:00am
Sunday, July 21 at 9:00am to 10:00am
Monday, July 22 at 9:00am to 10:00am
Tuesday, July 23 at 5:30pm to 6:30pm
Wednesday, July 24 at 9:00am to 10:00am
Thursday, July 25 at 5:30pm to 6:30pm
Saturday, July 27 at 9:00am to 10:00am
Peaked Hill Studio 7 Woodland Center, 455 State Road, Vineyard Haven, MA 02568
$15 to $20
Login to interact with events, personalize your calendar, and get recommendations.


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Over 40 Hired Well the real title is, Over 40 & You're Hired by Robin Ryan, the woman CBS radio called 'the leading job expert'. This book is a treasure trove of up-to-the minute information and ideas for those looking for a job after age 40.
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text: KPMG: IBM, KPMG, Merck, Walmart team up for drug supply chain pilot 20-Jun-2019 IBM announced its latest blockchain initiative today. This one is in partnership with KPMG, Merk and Walmart to build a drug supply chain blockchain pilot...read more IBM: IBM and the NHS: Working in Partnership 19-Jun-2019 As a new generation of technology is changing our lives there are no shortage of opportunities for technology to revolutionise the National Health Service. But it's not just about getting the current systems working better for the 1.4 million NHS staff and over a million patients the NHS sees every dayread more IBM: Quantum Computers Market to Witness Astonishing Growth with Key Players| D-Wave, IBM, Google 29-May-2019 Read an extensive analysis of the Global Quantum Computers market strategy of the leading companies in the precision of import/export consumption, supply and demand figures, cost, price, revenue and gross margins. read more IBM: Major Ocean Carriers CMA CGM and MSC to Join TradeLens Blockchain-Enabled Digital Shipping Platform 29-May-2019 Global container carriers CMA CGM and MSC Mediterranean Shipping Company today announced they will join TradeLens, a blockchain-enabled digital shipping platform, jointly developed by A.P. Moller - Maersk and IBM. Data for nearly half of the world's ocean container cargo will be available on TradeLensread more IBM: Data Challenges Are Halting AI Projects, IBM Executive Says 29-May-2019 International Business Machines Corp. executive Arvind Krishna said data-related challenges are a top reason IBM clients have halted or canceled artificial-intelligence projectsread more IBM: C-suite executives are ready to double-down on cloud computing 22-May-2019 At a time when the hype around emerging technologies such as autonomous cars and augmented reality seems to be sky-high, C-suite executives are keeping their feet firmly on the ground when it comes to investing in a core area: cloud computing. Studies show that executives' interests are evolving beyond basic cloud solutions to more flexible and versatile ones, such as hybrid cloud.read more IBM: ExtraHop for IBM QRadar part of collaborative development to stay ahead of evolving threats 21-May-2019 ExtraHop, provider of enterprise cyber analytics from the inside out, launched the ExtraHop for IBM QRadar app, which integrates with IBM Security Intelligence technology to stream accurate, contextual network behavioral detections into the QRadar SIEM.read more IBM: HCL Technologies will make space for 2,000 IBM staff 15-May-2019 BENGALURU: HCL Technologies plans to take on board nearly 2,000 IBM employees as part of its $1.8-billion deal to acquire some of the latter's software assets, as the Noida-based tech services exporter adopts a strategy to shore up its IP-led business faster than traditional software services. read more IBM: A 'smoking good' deal? Red Hat could prove a $34 billion bargain for IBM 15-May-2019 When does free technology become worth $10 trillion? When the company is Red Hat Inc. and its open-source software and applications running on Red Hat Enterprise Linux contribute to $10 trillion worth of global business revenues this year.read more IBM: IBM Is Making Artificial Intelligence Easier and Renaming Solutions for AI 29-Apr-2019 I was recently at a great AI workshop put on by IBM. IBM went over their AI strategy, directions and futures, as well as gave us hands-on labs to run the key products in the IBM AI portfolio writes Ron Gordon - Director of Power Systems forread more IBM: Nestle, Carrefour Team Up to Feed Consumers Data With IBM Blockchain 25-Apr-2019 Swiss food giant Nestle and French retailer Carrefour are now letting consumers access product data via IBM's Food Trust platform.read more Microsoft: Amazon, Microsoft finalists for $10 billion government cloud contract 11-Apr-2019 IBM and Oracle have reportedly been ruled out for a U.S. Defense Department contract for cloud computing services that could be worth as much as $10 billion over the course of a decade.read more IBM: Find out what's possible in digital transformation, with IT built to do more. 08-Apr-2019 Today's biggest challenges involve managing huge amounts of data and getting the most value from it while also keeping that data secure. read more Digital Ecosystem: why your digital customer strategy will fail without a solid technical foundation 08-Apr-2019 A perspective from Moorhouse Consulting:Engaging a digital customer requires harnessing the power of data, embedding customer focus across the digital ecosystem, and enabling agility through a technology bedrock. read more Microsoft, Google and IBM listed as Visionary Leaders by 360Quadrants for Artificial Intelligence in Retail 20-Mar-2019 360Quadrants powered by MarketsandMarkets, the world's only comparison platform that combines expert analysis with crowdsourced insights has released a quadrant on Artificial Intelligence in Retail industry to help businesses make quicker and more informed decisionsread more IBM: IBM Cloud helps UK Startup to create AI-Powered Assisted Living Solution 13-Mar-2019 UK care management start up Karantis360 has turned to IBM to help build a new solution that uses sensors and Watson artificial intelligence running in the IBM Cloud to enable people who need assistance to live more independently in their own homes.read more IBM: Here's What Happened When IBM's Advanced AI Machine Challenged An International Debate Champion 26-Feb-2019 Aristotle broke ground by claiming that the art of persuasion—rhetoric—can be learned. Although Aristotle was right, he may never have envisioned a day when a machine could also be taught to argue. It took 2,300 years for it happen, but it happenedread more Samsung and IBM Collaborate to Strengthen Blockchain Ecosystems 18-Feb-2019 During IBM's annual conference focused on technology and business, Samsung SDS announced it is continuing its collaboration with IBM in support of advancing Hyperledger Fabric, an open source cross-industry blockchain technology, with recent code contributions, research and a new white paper. read more Capgemini Consulting: UK Software Testing Market 2019 – IBM, Capgemini, Wipro, Cognizant, HP 18-Feb-2019 The UK Software Testing Market report is an in-depth study that covers market insights, facts, historical data, and statistically supported and industry-validated market data. It covers up-to-date marketing information which is important to monitor performance and make critical conclusions for growth and effectiveness of businessread more Parts of audit work to go to tech firms, new report finds 11-Feb-2019 The audit process, one of the most vertically integrated professional services left in today's market, is being broken down into separate parts by audit clients, creating a huge opportunity for technology firms to enter the market, a new report finds today. read more


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Hey and mild readers, welcome to the SwitchArcade Spherical-Up on June 14, 2019. The E3 2019 present is over, and the house owners of Nintendo Change have a whole lot of expectations within the coming months. For all of the hustle and bustle of this week, it has been very quiet to this point immediately. However don't fear, pals. We nonetheless have some attention-grabbing information to cross, some new variations to view, and a surprisingly highly effective gross sales listing. Let's end the week!
Nintendo Tree Home reveals some ' Hole Knight: Silksong'
Final 12 months, Hole Knight quickly grew to become a favourite of many Change house owners. After all, everybody will see something within the subsequent cease of the Cherry group, which seems to be a brand new chapter within the Hole Knight world. This time, the protagonist is a bumblebee. This sport will clearly seem quickly, so it may be performed on the E3 in 2019. As a part of the present's protection, the Nintendo Tree Home confirmed off the Silksong present that was performed there for about fifteen minutes of gameplay. Now, if you happen to don't wish to destroy something for your self, I gained't blame you, however it seems nice. If Silksong is near any time within the first sport, then the a part of the sport proven on this video will solely be a drop in the entire sport, however it's good to see the way it shaped.
'Hangry Horde Night time'DLC is now accessible for overcooking! 2'
When you've got filtered all of the content material presently accessible in Overcooked! 2 on the lookout for extra, Staff17 and Ghost City Video games are very completely satisfied to simply accept. The evening of Hangry Horde can now be bought on eShop for $9.99. It provides a brand new tribal mannequin, with eight ranges to face up to undead meals and making an attempt to reverse the scenario. You additionally get 12 new common ranges, together with 9 new kitchens and three hidden Kevin ranges. There are 4 new cooks, three of whom are monster-themed, and the final one is the extremely acclaimed Boxhead chef within the first sport. Put in some new mechanisms like guillotine and new recipes like fruit pies, and you've got a scrumptious new service that may hold you busy for some time.
HORI's Break up Pad Professional will probably be launched within the West
There have been a whole lot of unusual equipment in Japan, and I by no means actually went anyplace earlier than. After I first noticed HORI's new Break up Pad Professional, it was clearly designed for Daemon X Machina. I don't prefer it very a lot. Decide if it'll change into one thing the corporate desires to publish globally. Nonetheless, clearly it does. An inventory of controllers has appeared on Amazon, by way of which we will roughly verify its performance. First, like HORI's left D-Pad controller, the Break up Pad Professional can solely be utilized in handheld mode. It have to be linked to the Change to work. As well as, it doesn't have the rumble, gyroscope, NFC learn perform or IR sensor within the common Pleasure-Cons. What does it do? Full-size analog joystick, good directional keyboard, giant shoulder buttons, and fast pictures, additional programmable triggers and additional buttons for assignable buttons. It's absolutely licensed by Nintendo and can due to this fact arrive on September 30th for $49.99.
new model
arcade archive Pooyan ($7.99)
Konami is thought for his number of video games: nice taking pictures video games, progressive stealth strikes, commandos and aliens, and unusual guys with a whip in opposition to Dracula. A gritty iron. However its earliest blow concerned a sow with an arrow popping up a balloon that stole her little one's wolf. Pooyan is a reasonably previous sport that was first launched in 1982, however as a sport of the sport, it ages fairly properly. This doesn't essentially imply that you should have a whole lot of enjoyable immediately, however it performs properly in a short while. Hamsters do basic work right here, so if you wish to play some Pooyan, it is a excellent means.
useless dungeon ($four.99)
Lifeless Dungeon is a difficult single-screen stage stencil sport. And, you realize, excellent. It principally does what it wants. You may get the extent of the exit it is advisable to open by gathering the merchandise, and the merchandise is normally closed on one other a part of the stage, which requires you to drag out some tough platforms to succeed in. In case you are useless, you have got began from the start. You'll die so much, however you can be born once more quickly, so this isn't so dangerous. This has some respectable music, but when I'm trustworthy, the visible results will not be essential to me. Though the extent design is just not dangerous, the sport lacks gimmicks and can assist it stand out in a reasonably crowded sort. Nonetheless, 5 ? That is very respectable.
Verlet Swing ($14.99)
Okay, on the one hand, I actually respect how extremely bizarre the sport is. It has the standard of Umihara Kawase, the place the stage is extremely surreal and you're struggling. However right here, you're doing it in 3D. That is okay if there's a lack of gameplay in its unique type, however this port is just not the perfect. It feels very tough in some ways, and ultimately it's extra like an experiment than a sport. Like, I do know lots of people like to simply take a look at a bizarre sport like this or simply respect one thing completely different. If that is you and the value doesn't trouble you anyway. However even with this in thoughts, you may wish to play it in your pc if you happen to can.
Vosaria: Forgotten Nest ($four.99)
A facet scrolling sport with numerous weapons and vitality boosts to gather, Vosaria's foremost turning level is to permit gamers to leap to the ceiling. Sure, similar to that sport. But it surely's probably not an identical sport, so don't fear an excessive amount of about it. The sport seems and feels somewhat off on the lower-budget facet, however it's not too dangerous to play. I gained't suggest it with nice enthusiasm, however its worth and the value it affords, it is a good sport. I simply need the protagonist to be higher animated. Sure, that is purely a beauty problem, but when the protagonists don't stroll like their full diapers, the sport is perhaps a lot better.
Okay, I assume I requested, isn't it? After I'm fairly certain that many of the video games that went on sale this week have already began promoting, I wakened and checked out one other prolonged listing. Now, I admit that these will not be all-stars in most of Change's lineups, however there are some nice video games like Axiom Verge, Tremendous Daryl Deluxe and New Star Supervisor. I might additionally like to attract consideration to the promotional worth of Child Tripp. When you've got 79 Gold Factors in your eShop pockets and even a number of spare cash, it is a nice option to eat them. Most video games that full the low cost interval this weekend will begin over within the close to future, however if you happen to've already centered on the Goat Simulator, it is perhaps a bit earlier than we see it once more.
new sport sale
Tremendous Daryl Deluxe ($19.99 from $19.99 to six/20)
Bulb Boy ($1.99 from $7.99 to June 27)
Lichtspeer: Double Speer ($three.49 between $three.99 and $9.20)
Butcher ($three.49 between $three.99 and $6.20)
Axiom Verge ($19.99 from $19.99 to six/20)
Sparkle 2 EVO ($four.99 from $four.99 to 7/three)
Child Tripp ($zero.79 from $three.99 to 7/four)
Dimension Drive ($6.49, from $12.99 to June 26)
Black Fall (from 14.99 USD to June 27, $7.49)
Hole ($1.99 to $19.99 to 7/three)
Guilt Battle Area ($three.99 to $9.99 to three.75) USD)
I, Zombie ($2.49 to $four.99) 19/three)
Zombillie ($four.99 from $four.99 to 7/three)
Animated puzzle: Japanese panorama [194] 59005] (from $9.99 to June 27 $four.99)
Regalia: Of Males and Monarchs ($24.24 to six/20 from $16.24)
L.F.O. -Misplaced Future Omega- ($three.99 to $7.99 to $6.76)
Tremendous Sportmatchen ($eight.99 to $14.20 to $eight.75)
My Farm ] ($6.99 from $9.99 to six/20)
Phantaruk ($four.99 from $four.99 to 7/three)
Harmful Mouse: Harmful Recreation ($three.99 From $four.99 to 7/three)
Jackbox Celebration Pack 5 ($17.99 to $29.99 to June 27)
Puzzle Wall ($three.99 to 7.99) USD to June 27)
Bug Butcher ($5.59 to $7.99 to June 26)
Teddy the Wanderer: Canoe (from $zero.99 $9.99 to July three)
Teddy the Wanderer: Mountain Hike ($four.99 from $9.99 to 7/three)
Ethan: Meteor Hunter ($three.99) From $9.99 to six/20)
Viviette (7.9 $9 from $9.99 to 7/three)
Cake Lab ($2.99 from $2.99 to June 30) [19459] 007] Diggerman (from $four.99) $four.99 to 7/three)
A Ch'ti Bundle ($6.99 from $15.99 to six/20)
Inside My Radio ($three.99from $9.99 as much as 6/20)
My Arctic Farm 2018 ($6.69, from $9.99 to June 20)
My unique farm 2018 ($6.99 from $6 9.99 to six/20)
Nova Supervisor ($11.99, from $19.99 to June 20)
Agartha-S ($three.99 from $7.99 to six) 27th)
Surfingers ($zero.49 from $four.99 to 7/three)
Dangerous Dream: Fever ($four.99 to $four.99 from September three) )
Pet Ninja Gold Mission (from $5.00 to $eight.00 to June 27)
Again to mattress ($three.99 from $four.99 to June 26) [)]
My time in Portia ($23.99 from $29.99 to June 26)
Mainlining ($12.74, from $14.99 to July three)
The Childs Sight ($four.04, from $four.99 to six/20)
Rally Rock' N Racing ($7.99 to $9.99 to $7.9)
Entrepreneur Child ($7.50 to $7/1, $7.50)
Finish of gross sales this weekend
Soulblight ($14.99 from $14.99 to six/15)
Workplace Quest ($four.99 from $11.99 to six/15)
Tyr :Chains of Valhalla ($7.99 to $9.99 to June 15, 2015)
Alteric ($2.24 to $16.24)
Anima: The Gate of Recollections – Nameless Chronicle ($19.99 from $19.99 to June 16, 2016)
Anima: The Gate of Recollections ($19.99 up from $19.99 to six/16 )
Awe ($three.99 from $four.99 to six/16)
Construct a bridge! ($eight.99 till June 16, 2016)
Loss of life Synchronization: Tomorrow comes ($5.99 to June 16 cost $5.99)
Satan Crystal (from $14.99 to $eight.24 on June 16, 2016)
vitality stability (from $2.99 to $1.01 on June 16, 2016)
Freaky Superior ($ 7.14 up from $ 12.99 to six/16)
Ginger: Past Crystal ($19.99 from $19.99 to six/16)
Goat Simulator: GOATY ($14.99 to $29.99 to June 16, 2016)
Jungle Z ($10.39 from $12.99 to June 16, 2016) [)
Mars: Chaos Risk ($599, from $9.99 to June 16)
Nightmare Boy ($four.99 to $9.99 to $four.99)
North ($1.99 to $2.99 to $1.69)
Refunct ($1.99 to $2.99 to 16/16)
The Mooseman ]($four.54from $6.99 to six/16)
The place is my buddy? ($1.01 from $5.99 to six/16)
This would be the factor of the week, pals. This week has handed. What's your most fun information? What video games did you purchase? What pre-ordered you? I don't understand how I'll purchase what I would like this 12 months, however I doubt that we are going to endure this destiny collectively. I hope that you've an excellent weekend and proceed to thanks for studying!


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driver side window repair for Chrysler Crossfire E Class Executive Fifth Ave
windshield replacement for Hummer H1 H2 H3
Check out this thorough listing of everything you need to know to keep the Audi contemporary, balanced, and properly cared for this summer season.
One other key change around the inside is into the offered touchscreen infotainment process. We've derided Acura's twin-display setup previously, largely because it was hard to try to remember ways to get to the desired functionality, but also as a consequence of its gradual response periods and baffling menu composition.
The ILX has comfortable seats as well as a ride tuned a lot more for consolation than general performance. The climate Handle procedure is functional and simple. But cabin noise is often a well known issue.
Do you might want to repair or change the Acura window regulator? Or, is there a loud sounds when rolling the window down? The mechanism which lifts and lowers a vehicle window is generally known as the window regulator. Acura window regulators use reverse polarity and possess two wires.
Effectively-Geared up prospective buyers will not likely should hire a mechanic to install this element as it's a immediate-match element; It can be produced in accordance to OE expectations. Intended to generally be installed to the front driver side, this item is offered independently.
For customers trying to find a spending plan-welcoming nevertheless very dependable ingredient, the Dorman window regulator is often a best possibility. Designed to be a window regulator to the rear passenger side, this merchandise is patterned following the specs in the manufacturing unit-set up part. What this means is it's sure to match just like the authentic aspect.
It was plasticky, loud instead of specifically very good to generate. Honda produced improvements to it inside the intervening decades, and Acura has accomplished its personal operate. But the truth is usually that it's just not the most effective auto on which to foundation a luxury sedan.
As mentioned from the former query, This may be described as a situation from the cable during the window coming off. Since it is probably not possible to exchange the cable In the event the click here information is broken, the rear window regulator should be replaced to repair this issue.
In case you have additional issues on Acura window switches and so are seeking solutions or second opinions, Gurus on-line is often contacted for affordable and ideal options. This support is accessible with the convenience of your own home.
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It can be engineered using prime-of-the-line components and it is meticulously examined under the watchful eyes of nicely-experienced staff. Just about every part of this regulator is strictly inspected to make certain greatest effectiveness and performance even though exposed to harmful elements. Installation won't be a dilemma in any way mainly because it's a immediate-healthy component. It truly is intended to match the first component's specs to some T.
Windshield repairs by California Auto Glass supply a time tested way to increase the existence of your windshield. The windshield repair approach essentially replaces the compact bits of glass which can be missing Once your windshield chips or cracks.


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Monday, March 18, 2019
SSC200 Sketchy 200TH CelebrationStampinwithAnita March 18, 2019
Hello, welcome to Stampin With Anita. I signed up to be a Stampin' Up! Demonstrator in Oct. 2017. Since then I have promoted to Silver and have 4 people on my team. I hold a monthly workshop at our home where I try and teach techniques that are fun and creative.
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6 comments:
Beautiful sponging and stamping! Perfect colors and design. Thanks for joining us at Sunday Stamps, hope to see you again soon!ReplyDelete
Thank you, Amy!ReplyDelete
Wow, Anita, that background is amazing - great job with your sponging! Perfect for setting off your bold stem, but I really like those colors together! Thanks so much for playing at Sunday Stamps!ReplyDelete
Very pretty background for your image! Thanks for sharing with us at SUNDAY STAMPS :)ReplyDelete
Oh AnitaReplyDelete
I love your sponged backgroun
really vibrant and your silhouette flower is beautiful with this background
Love this much
Many thanks for using my sketch and joining our challenge #200 at Sunday Stamps
Monika (DT)
PS: if you like to visit my DT card I will be thrilled....
Thank you Monika! I would love to check out your card!ReplyDelete
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I am a wife of 43 years married to my best friend, Mike. He has always been my biggest supporter. We have 3 beautiful daughters and 2 wonderful grandchildren. Also, I am a college graduate, still working full time, and trying to squeeze in every crafting moment possible. Working with my hands, whether it is papercrafting, stamping, painting, cross-stitching, zentangling or quilting - brings joy to my life. I love color in all its various forms.
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DNA uptake during transformation of Bacillus subtilis. Public Health Research Institute and Department of Microbiology and Molecular Genetics University of Medicine and Dentistry Newark, New Jersey. Look here throughout for the names of the people who did the work!.
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DNA uptake during transformation of Bacillus subtilis Public Health Research Institute and Department of Microbiology and Molecular Genetics University of Medicine and Dentistry Newark, New Jersey Look here throughout for the names of the people who did the work!
Not another transformation talk! Edvard Munch
+ + Genes for DNA uptake ComK is the Master Regulator of Competence Pr comK
Competence Develops in Stationary Phase T 0 Transformation Growth Time
comK Synthesis Begins in Stationary Phase T 0 ComK Growth Time
Competence gene expression exhibits heterogeneity This shows a culture with a GFP fusion to a competence protein (ComK-GFP) Only 10-20% of the cells express competence! Jeanette Hahn
DNA Uptake: take home lessons 1. DNA uptake is mediated by two subsets of proteins that probably form complexes. 2. The first subset provides for access across the wall. It involves a pilus-like system. 3. The second subset includes three proteins that mediate membrane transport. These proteins may constitute an atypical ABC transporter. 4. DNA uptake probably takes place preferentially at the cell poles and at least some competence proteins are localized at the poles. (All the proteins to be discussed are under ComK control).
Binding Fragmentation Transport and degradation Integration TRANSFORMATION PATHWAY
comK comK comK comE operon (EC) EA DNA binding protein Major pilin-like protein GA GB GC GG GE comG operon GD GF ATP binding protein Integral membrane protein comC C Type 4 pilin-like proteins peptidase Proteins needed for DNA binding: Mark Albano, Jeanette Hahn, Sandhya Mohan
ComG ComC ComEA ComEA is a DNA receptor. It is an integral membrane protein. NucA is the fragmentation nuclease. It is an integral membrane protein. NucA But why are the ComG/ComC proteins needed for DNA binding? Roberta Provvedi, Young Sook Chung
The ComG/ComC proteins are needed to provide access to ComEA OUT Wall ComG proteins ComEA NucA Hypothesis: The ComG proteins form a complex (a pseudopilus) that may traverse the wall. Roberta Provvedi
Type IV pilins and pilin-like proteins hydrophobic core F prepilin peptidase cleavage Neisseria pili Klebsiella pseudopilus (Sauvonnet et al. EMBO J. (2000)19:2221)
The protoplast supernatant lysozyme osmoprotectant Gram positive cell (B. subilis)
s-s NH 2 ComGC monomer is oxidized, cleaved and translocated In protoplast supernatant COOH BdbDC S-S HS ComC OUT SH Integral membrane protein What are the roles of ComC, BdbD and BdbC? Does ComGC form a higher order structure? Roberta Provvedi, Ines Chen, Young Sook Chung & Sierd Bron lab
ComC is an integral membrane peptidase that converts pre-ComGC, pre-ComGD, pre-ComGE and pre-ComGG to their mature forms Young Sook Chung
ComC is needed for the translocation of ComGC Young Sook Chung
ComGC has an intramolecular disulfide bond MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGLQNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH Young Sook Chung
BdbD and BdbC are thiol-disulfide oxidoreductases required for competence bdbD bdbC ComK Sierd Bron lab, Mark Albano
BdbD and C are needed to stabilize ComGC, probably by introducing the disulfide bond bdbDxbdbC bdbCxbdbC comGA12 Protoplast supernatant bdbD bdbC WT bdbDxbdbC bdbCxbdbC Membrane comGA12 bdbD bdbC WT Ines Chen, Roberta Provvedi, Sierd Bron Lab
S BdbD S S BdbD S BdbDC act as oxidoreductase partners to introduce a disulfide bond in ComGC Oxidizing agents Added oxidizing agents (GSSG or cystine) S BdbD S OUT BdbC Reduced ComGC (unstable) Oxidized ComGC (stable)
ComGC forms a multimeric complex stabilized by disulfide bonds ComGC in protoplast supernatant + bME - bME kDa 46 29 20 15 5 comG comG Ines Chen, Roberta Provvedi
All the comG genes are necessary for ComGC complex formation wt DA DB DC DD DE DF DG GA(ATP) ComGC in protoplast supernatant Ines Chen
- + - + IPTG - + - + - + - + ßSH Strain has Pspac-comG, Pspac-bdbDC, Pspac-comC and is comK. The ComC, BdbDC and ComG proteins are sufficient as well as necessary for complex formation comGC monomer Ines Chen, Petrina Boucher
s-s BdbDC S-S HS ComG proteins ComC SH s-s s-s Processing and Assembly of ComGC multimer
Wall ComGC ComEA NucA ComGC does form a multimeric complex, providing access to ComEA OUT What is the composition and structure of the complex? Does the ComGC multimer traverse the wall and provide a passageway for DNA, as shown? Is the structure dynamic? Does its disassembly draw DNA into contact with ComEA?
Three membrane proteins needed for DNA transport DNA binding protein Out EA EC FA In ATP binding protein Putative channel protein Gordon Inamine, Roberta Provvedi, Arturo Londoño, Irena Draskovic, Jeanette Hahn
DNA binding may induce bending and presentation of DNA to the channel "QQGGGGSVQSDGG" linker (When linker is deleted, DNA binding still occurs, but no transport. So ComEA is needed for both steps) Dual role of ComEA Out EA EC FA In Putative channel protein Gordon Inamine, Roberta Provvedi
Role of ComFA 1. Required for transport, not binding. 2. Resembles DEAD family helicases and PriA. 3. Integral membrane protein, accessible to protease only from inside. 4. Walker A site essential for function. Out EA EC FA In ATP binding protein ComFA may be needed to drive DNA translocation, for gating the channel or as a helicase. Arturo Londoño
Topology of ComEC: absolutely required for transport N-loop OUT 1 2 3 4 5 phoA lacZ Both Irena Draskovic
ComEC has an intramolecular disulfide bond WT WT comEC comEC + - + - DTT Irena Draskovic
Oligomerization of ComEC + NEM 0' 10' 30' 60' 0' 10' 30' 60' Dimer EC monomer Cys is used here as a natural crosslinker. This disulfide bond does not occur in vivo. Irena Draskovic
Which cysteine residues are responsible for the in vivo intramolecular disulfide bond and for the in vitro cross-linking? Irena Draskovic
C C C 7 6 8 ComEC has 8 cysteine residues Each of the Cys residues has been converted to Ser. C2 C3 N-loop OUT C1 C4 C5 Irena Draskovic
The intramolecular -S-S- bond is in the N-loop C2 and C3 form an internal disulfide bond wt C2/C3 EC+N KO+N - + - + - + - + DTT EC(-SH) EC(-S-S-) ECN ECC2/C3 is degraded ECN is stable; no shift in mobility Irena Draskovic
Introduced by BdbDC C S mutations in the remaining 6 Cys residues do not affect stability, transformation or the mobility shift. ComEC Disulfide Bond S S N-loop 1 2 3 4 5 Irena Draskovic
BdbD and C are needed to introduce the N-loop disulfide bond wt bdbDC comG comC - + - + - + - + DTT (-SH) EC (-S-S-) EC Irena Draskovic
wt C6/7S C8S C6/7/8S 0 10 20 60 0 10 20 60 0 10 20 60 0 10 20 60 Dimerization assay Conclusion: ComEC dimerizes using contacts near cysteines (6), 7 and 8. Irena Draskovic
C C C 6 7 8 Disulfide bond (in N-loop) and the oligomerization helix S S 482 483 494 N-loop xxxxCCxxxxxxxxxxCx 1 2 3 4 5 Irena Draskovic
Protein motifs in ComEC S S N-loop 1 2 3 4 5 BPD Metallo-ß-lactamase domain Irena Draskovic
What is the BPD (Binding Protein Domain) motif? 1. Present in the permease component of ABC transporters. 2. Probably involved in protein-protein interactions, most likely with the ATPase component. 3. Several point mutations in the BPD of comEC inactivate function without affecting protein stability. Irena Draskovic
BPD mutants ComEC RAA - - - G- - - - -S- - - - -RV E -D- - - P L - S wt RE RL AD AS GP - + - + - + - + - + - + DTT 100% 2% 4% 36% 88% 6% Transformation frequencies Irena Draskovic
What is a metallo-ß-lactamase domain? 1. Present in a large family of proteins. 2. Includes enzymes that use water for nucleophilic attacks on covalent bonds. Usually with dinuclear Zn(II) centers. 3. Substrates often esters with associated negative charges. 4. Artemis: Involved in V(D)J recombination and double strand break repair. Processively degrades ssDNA (5'3')!!! 5. Several point mutations, introduced in this domain of comEC, lose function without affecting stability. 6. Possible roles in ComEC: Cell-wall remodeling? Non-transforming strand nuclease? Irena Draskovic
2% 3% 4% 4% ß-lactamase domain mutants LhDsG HxHxDHxG C/H LIDTG Motif 1 2 HADQDHIG 3 H N A A A hhxsGD hhxxH WILTGD Motif 4 KVGHH 5 Irena Draskovic
Cartoon of ComEC channel N-loop OUT 4 3 5 5 3 1 1 2 2 BPD c c c ß-lactamase domain Irena Draskovic
ComEC-10His Contacts ComEA Competent cells +/- DNA - - + + His tag - + - + DNA Crosslink (DSP) EC Isolate membranes unbound EC Solubilize membrane proteins EA unbound EA Pull-down ComEC (Ni2+-resin) Irena Draskovic
DNA binding protein Out EA EC FA In ATP binding protein Putative channel protein Could these three proteins constitute an (atypical) ABC transporter? 1. Three components: ligand binding (ComEA), polytopic membrane permease (ComEC) and ATPase (ComFA). 2. ComEC is a dimer (so is ComEA). 3. ComEC has 5 transmembrane segments per monomer. 4. The BPD domain plays a role. 5. The ATP binding site of ComFA is essential for transport. 6. ComEA and ComEC contact one another.
But, transport may not be driven directly by ATP hydrolysis. Inhibitor data from the Konings lab (Groningen) suggests that transport is driven by the pH component of PMF. Perhaps ComFA plays a signaling role (channel gating?) or is needed as a helicase, while PMF drives transport.
receptor (EA) DNA uptake permease (EC) ABC cassette (FA) Irena Draskovic
receptor (EA) DNA uptake NucA permease (EC) ABC cassette (FA) Irena Draskovic


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The average salary for a Vice President (VP) of Product Development with Business Development skills in San Francisco, California is $189,868.
Is Vice President (VP) of Product Development your job title? Get a personalized salary report!
$117k - $278k
$21k - $45k
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$123k - $303k
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Job Description for Vice President (VP) of Product Development
Vice presidents (VPs) of product development are usually members of the upper-management team within an organization. This position is classified as a technology job and usually reports to the chief technology officer, the chief engineering officer, or another department leader. Vice presidents of product development usually have many employees who work under them and a group of managers who report in directly to them. Individuals in this position are responsible for managing all product develop…Read more
Vice President (VP) of Product Development Tasks
- Lead product development and production teams from initial inception to final product.
- Guide product placement and pricing strategies.
- Ensure that products meet the brand standards as well as consumer needs.
- Conduct technical, competitive, and trend analysis to identify and evaluate potential products.
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Skills that pay less than market rate include Project Management, Data Analysis, Strategic Project Management, Product Management and Product Development.
Pay by Experience Level for Vice President (VP) of Product Development
An experienced Vice President (VP) of Product Development with 10-19 years of experience earns an average total compensation (includes tips, bonus, and overtime pay) of $189,868 based on 8 salaries. In their late career (20 years and higher), employees earn an average total compensation of $225,000.
Pay Difference by Location
Learn more about cost of living by city.
Employees with .NET Software Developer / Programmer in these locations earn less than the national average. The lowest salaries can be found in Chicago, Illinois (55.2% less), Minneapolis, Minnesota (21.0% less) and New York, New York (11.2% less).
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3 Window Planter Boxes
H Potter Window Box
- H Potter window box succulent flower planter. Stainless Steel with a antique copper finish.
- Drip tray included. Approximately: 16.5″L x 6″W x 5.5″H
- Shown with three 4 inch African violets, PLANTS NOT INCLUDED. Perfect for kitchen windowsill.
- Can be placed outdoors on a patio or deck. Indoor or outdoors this is a great accent for your home and plants.
- Designed and Manufactured by H Potter. Read More…
H Potter Williamsburg Window Box
- Stainless Steel Window Box with a Antique Copper Finish and drain holes.
- Mounting brackets allow you to mount under windows or on wooden decks.
- Included brackets also make removal easy for planting and care.
- Black Iron has a powder coat finish.
- Designed and Manufactured by H Potter. Available in three sizes: 30″L x 8″D x 8″H, 36″L x 8″D x 8″H, and 48″L x 8″D x 8″H. Read More..
H Potter Copper Window Box
- H Potter Copper Window Box Window Planter Boxes
- Mounting brackets and hardware included.
- Metal Frame with Black Powder Coat Finish
- Copper liner removes from metal cage for easy cleaning and planting.
- REAL copper liner not copper finish. 48″ length x 8″ depth x 8″ height


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Home prices in April were 3.5% higher than a year earlier, according to the S&P CoreLogic Case-Shiller U.S. National Home Price Index.Real Estateread more
Allergan shareholders will receive 0.8660 AbbVie shares and $120.30 in cash for each share held, for a total value of $188.24 per Allergan share.Biotech and Pharmaceuticalsread more
Investors are piling into gold, sending the precious metal to a six-year high on Monday, and analysts think the commodity has established a base to go even higher.Marketsread more
The Conference Board, a business research group, on Tuesday released the June update for its consumer confidence index.Economyread more
The Congressional Budget Office estimated Tuesday that the national debt will rise to 141% of the economy over the next 30 years — 11 percentage points lower than the agency...Economyread more
Amazon announces that Amazon Prime Day will last for two days, starting July 15.Technologyread more
Joe Biden could face some uncomfortable questions about his record on women this week at the first Democratic presidential debates in Miami.2020 Electionsread more
Investors plow into the precious metal amid the prospects for lower interest rates, a softer global economy and increased geopolitical tensions.Marketsread more
FedEx sued the U.S. to block it from enforcing rules requiring it to police packages coming into the U.S. that may pose a threat to national security — placing the shipping...US Marketsread more
FedEx heads into Tuesday afternoon's earnings deep in a bear market. A failure to deliver could mark a massive buying opportunity.Trading Nationread more
"What else do you have to do that will actually have to affect the Iranians' calculus?" said Amos Hochstein, who served as U.S. special envoy for international energy affairs...World Politicsread more
Strong El Niño conditions will likely persist well into next year, but speculation that the event could shatter records may be premature.
There is an 80 percent chance the weather phenomenon—which causes unusually warm ocean temperatures in the Equatorial Pacific—will continue through the Northern Hemisphere's spring next year, according to an update Monday by the National Oceanic and Atmospheric Administration's Climate Prediction Center. While some recent models have suggested El Niño could become the strongest on record, those concerns may be overplayed, according to Mike Halpert, deputy director of the CPC.
"We're favoring a strong event, but we're certainly not favoring a record event," he said.
Read More What is El Niño, anyway?
Effects from the temperature rise vary, but El Niño can lead to increased rainfall and flooding in the southern U.S. and drought in the West Pacific, according to the NOAA. A strong event could have huge effects on California, which is mired in the fourth year of a drought.
Probabilities from forecast models released earlier this month suggest a 60 percent chance the current El Niño will be stronger than the record-setting event in the winter of 1997 and 1998, which caused severe weather systems in various corners of the U.S. But the forecasts from the North American Multi-Model Ensemble generally predict higher temperatures than come to pass, Halpert stressed.
"When you deal with El Niño, they bias very warm," he noted.
Read MoreThe California drought is even worse than you think
Halpert pointed to NMME forecast models for the Niño 3.4 region in the Pacific Ocean ahead of the 1997 event. Models in September predicted an average temperature departure of 3 degrees Celsius (5.8 Fahrenheit) from October to December of that year, but they ended up being 2.3 degrees Celsius above normal (4.14 Fahrenheit).
Halpert added that the biggest effects from El Niño should come in the winter, and climate variability makes it difficult to predict months ahead of time.
Update: This story has been updated to clarify the forecast models ahead of the 1997 El Niño.


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Writing NSW - Online Feedback - Children's Books
with Aleesah Darlison
Commences 24th February 2019
Concludes 5th July 2019
Where: Online
When: 24th February 2019 - 5th July 2019
Full Price: $410
Member: $290
Conc Member: $250
You've written some picture books or books for early readers – maybe you've even got a stack of drafts sitting in a drawer. You know they could be better, but you're not quite sure how. Sound like you?
Personal feedback is an effective way to sharpen and refine your work. Feedback provides valuable insight into your writing and can help you develop your editing skills and critical eye.
In this online program, award-winning author Aleesah Darlison will provide feedback on your writing for children, enabling you to hone your skills over five months. Feedback will vary depending on each submission, but it may focus on areas such as storytelling, plot, structure, characterisation, theme or voice.
Once a month, from February to June, you'll submit either a picture book text (up to 800 words) or an early reader/chapter book text (up to 1500 words). Your tutor will provide tailored feedback, giving you time to incorporate her suggestions and advice into the next month's submission. Each month, you can submit either new or revised writing.
You'll also have the opportunity to read and comment on other participants' writing. This process of giving and receiving feedback from fellow writers is an ideal way to determine what works, what resonates, what falls flat – and how to improve.
This online program takes place on a website specifically designed for writers, making it simple and easy to share your writing, give and receive feedback, and interact with fellow writers.
If you're ready to challenge yourself and develop your skills through constructive critique and independent work, this is the program for you.
Full details: writingnsw.org.au/whats-on/courses/online-feedback-childrens-books-aleesah-darlison


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Cabaret Night at PSLC…
Broadway Cabaret Club are coming to PSLC on 14th June to perform a night of music and songs from the musicals 'Legally Blonde' and '9 to 5.
Book your tickets, bring your friends and sit back and enjoy a night of singing, dancing and feisty fun from this talented group. A sizzling start to your summer fun!
Show starts 8pm
Tickets €12.50 from www.eventbrite.ie
click here for more details:


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Yung may. Despite her elimination, she later returned as a guest singer along with former winner Coco Lee for a performance from Jessie J who was the series winner in the grand finals aired April 13, July 23, It simply means that the places they are living is only near with each other. She sang her own rendition of Adele 's " Rolling in the Deep ". Returning singers from Season 5 is not listed in the column.
SO true!
KZ Tandingan Confirms That She Is Dating An Acoustic Singer (Video)
Damang dama bawat binibitawang salita. Asilo June 14, Retrieved May 8, Copyright PhilNews. For her self-titled album, see KZ Tandingan album.


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Total Visits: 19
Learn Korean online with free Korean language tutorials, help with Korean grammar, and other free Korean language lessons. If you're visiting Korea or are interested in working at a Korean company, here are three benefits of learning Korean. Because Rocket Korean incorporates reading, writing, speaking, and listening; you're able to freely pick and choose what you want to learn based on your learning method.
Unlike other languages which evolved from pictographs, Hangul was purposely invented by King Sejong in 1443 to be as easy as possible for Koreans to learn. I'm a native Korean, and I love teaching Korean and learning other languages as well. The name of the Korean alphabet, Hangul (한글) means great script in Korean.
4. Korean grammar might be difficult to learn for native English speakers as it follows SOV pattern. Use apps that take you step by step processes on how to speak Korean and many other languages. Hangul is the native script that was created by the king in order for Korea's common people to learn how to read and write Korean easily.
Basic: learn about the three conjugation forms for verbs (past, present, future), and basic word order for sentences (hint: it doesn't always have to be in the same order, like in English). In our Korean immersion environment, students read, write, listen, and speak in Korean 24 hours a day, seven days a week.
To help you master hangul we created a series to introduce them and teach you a few words you can write with these characters Our video series gives you all the tips you Kstyleyo need to remember the Korean script. Joseph Gerocs, long-time Korean resident, has lived in both Busan and Seoul.


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There are numerous techniques to acquire the very best away from your holiday.Visiting different places, discovering the way of lives of the local area individuals, the flexibility of quiting at gorgeous, eye quiting views can only be carried out successfully through automobile. Be daring, explore the vacation destination by renting out a car.There are lots of car rental firms, you can easily rent an auto either online or when you are at the holiday season place.
Below are actually some recommendations on exactly how to get the best automobile rental:
1. Perform your investigation. Do you intend to make a reservation for the car online prior to heading to the destination or are you mosting likely to rent out an automobile when you go to the place. Decide on 3 to four auto rental firms that match your yearns for and requires like the amount of passenger, will definitely you be actually taking a trip through country roads. Seek the cars and truck rental business either through the phonebook or even via the world wide web. Look in particular every possible provider just before you make a choice, talked to around for suggestions as you do not desire to miss out on the very best cars and truck rental business.
2. Utilize the internet to look for a cars and truck rental provider is actually a quick and effective method of discovering the excellent vehicle rental business. There are contrast internet sites that will present an option of automobile rental firms as well as their rates. Making a reservation for an auto online along with the auto rental company can likewise assist you conserve amount of money. Most car rental company offer internet just price cut as well as some even help you to find a car at your preferred price when you give them your budget plan.
3. You can normally obtain good discount on car rental with packages like fly-drive-stay or even fly-drive. Such packages takes away your bother with hotels and resort or airline as it is all looked after in a bundle. Contact the holiday company about such plans.
4. If you have Air miles and also they will end, there are some car rental providers that will swap these discount rates to price cuts on your vehicle rental. In this way, you will certainly not squander your Air kilometers as well as you can create massive financial savings on your automobile rental.
5. Contact the vehicle rental business and ask them about their special offers, location, supply, pick-up sites, costs, unique rates, hotels and resort as well as airline company relationships, additional costs, insurance coverage, whatever you may think about that can assist lower what you must spend for your car rental and also what would create the automobile rental more convenient for you.
6. Decide on a pickup point; if possible at the airport upon your landing, your lodging or area of keep. Or even, discover one that is near you so it will not be a headache.
7. Select the auto according to your necessities. Discover an auto that could accommodate all individuals you'll invite it, the number of travel luggage if it is actually from the airport terminal. If you're taking a trip alone; it will be smart to book a smaller capability car as some automobile rental provider fee much higher for larger cars.
8. When you have actually created your option, the upcoming point to carry out is to schedule it. Some auto leasings consist of the appointment charge on the general rental payment, some billed an additional expense, ask the automobile rental regarding this in your analysis.
9. When gathering the cancun car rental rental cars and truck, inspection if there are actually offered upgrades at no charge. As you would certainly yearn for the best bargain and also the best cars and truck, the technique is actually to pick up your vehicle early in the early morning, when the various other cars have actually certainly not been actually come back but. Generally currently there is actually a lack on economic condition cars and also the agency could just give you an upgrade for a lower price.
Lastly, don't forget to review the steering certificate criteria, that is actually, perform you need to have to acquire a global steering permit. Looking into through cars and truck is actually most definitely a delightful means to acquire the greatest on your holiday season.


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Asthma and Chronic Rhinosinusitis: Diagnosis and Medical Management
AbstractAsthma is a prevalent inflammatory condition of the lower airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchial hyperresponsiveness (BHR). Symptomatically, these patients may demonstrate wheezing, breathlessness, chest tightness, and coughing. This disease is a substantial burden to a growing population worldwide that currently exceeds 300 million individuals. This is a condition that is frequently encountered, but often overlooked in the field of otolaryngology. In asthma, comorbid conditions are routinely present and contribute to respiratory symptoms, decreased quality of life, and poorer asthma control. It is associated with otolaryngic diseases of the upper airways including allergic rhinitis (AR) and chronic rhinosinusitis (CRS). These conditions have been linked epidemiologically and pathophysiologically. Presently, they are considered in the context of the unified airway theory, which describes the upper and lower airways as a single functional unit. Thus, it is important for otolaryngologists to understand asthma and its complex relationships to comorbid diseases, in order to provide comprehensive care to these patients. In this article, we review key elements necessary for understanding the evaluation and management of asthma and its interrelatedness to CRS. View Full-Text
Share & Cite This Article
Massoth, L.; Anderson, C.; McKinney, K.A. Asthma and Chronic Rhinosinusitis: Diagnosis and Medical Management. Med. Sci. 2019, 7, 53.
Massoth L, Anderson C, McKinney KA. Asthma and Chronic Rhinosinusitis: Diagnosis and Medical Management. Medical Sciences. 2019; 7(4):53.Chicago/Turabian Style
Massoth, Landon; Anderson, Cody; McKinney, Kibwei A. 2019. "Asthma and Chronic Rhinosinusitis: Diagnosis and Medical Management." Med. Sci. 7, no. 4: 53.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.


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Port Bailey, AK - Order Birthday Gifts Online
Send Birthday Gifts Online to Bring Magic on a Recipient's Face
You have already send flowers and cakes, now it's time to move on. Here we come with thoughtful birthday Gifts online in Port Bailey USA to impress near one. Birthday falls once in a year and it must be rejoiced with meaningful Gifts. We are fully overloaded with types of gifts for him and her to choose from. From gourmet to personalized, gift baskets to birthday balloon delivery, we cover all range of birthday gifts to meet the customers' needs.
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george w bush granddaughter
The Bush family in the Red Room of the White House (January 2005) seated from left to right: Marvin Bush, Laura Bush, George W. Bush, Barbara Bush, George H. W. Bush, Jeb Bush.
Current region: Texas
George W. Bush Presidential Center: Home of the Bush
George W. Bush Presidential Center. About Us; Through our three Impact Centers — Domestic Excellence, Global Leadership, and our Engagement Agenda — we focus on developing leaders, advancing policy, and taking action to solve today's most pressing challenges.
George H.W. Bush was the 'center of our family
Dec 05, 2018 · George H.W. Bush was the 'center of our family,' granddaughter Barbara Bush says. Barbara Bush told NBC News that she and her twin sister Jenna Bush …
George W. Bush shares adorable photo of meeting his
George W. Bush shares adorable photo of meeting his new granddaughter. Poppy Louise Hager entered the world yesterday in New York City, but we consider her an honorary Texan. Jenna and Henry chose her name as a tribute to her great-grandfather, 41, who was nicknamed Poppy as a child. We are grateful to God — and to Jenna and Henry — for this beautiful, healthy gift of life," said President Bush in a …
George H.W. Bush Funeral Photos – See the Bush Family at
The Bush family gravesite is located across the pond from the George H.W. Bush Presidential Library and Museum. 47 The casket is carried from the hearse to Bush's final resting place in a
George W. Bush's Daughter Barbara's Wedding – Simplemost
When you're the daughter and granddaughter of two former presidents, being in the spotlight is pretty much something you can't avoid. Still, Barbara Bush, daughter of former President George W
See George W. Bush's Family Christmas Photo with
George W. Bush's Adorable Granddaughters — and Dog — Steal the Show in Family Christmas Photo. Former First Lady Laura Bush took to Twitter on Christmas Day to share the smiling snapshot, which included her and her husband with twin daughters Barbara Bush and Jenna Bush Hager, as well as Jenna's husband, Henry Hager, and their daughters Mila, 4, and Poppy, 2. "Merry Christmas from our …
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[George W. Bush's grief for his dad, George H.W. Bush, is both intimate and historic] The young boy's battle with leukemia hit close to home for the former president and his wife.
George Herbert Walker Bush was born at 173 Adams Street in Milton, Massachusetts on June 12, 1924 to Prescott Sheldon Bush and Dorothy (Walker) Bush. The Bush family moved from Milton to Greenwich, Connecticut shortly after his birth. Bush was named after his maternal grandfather George Herbert Walker, who was known as "Pop", and young Bush was called "Poppy" as a tribute to his …
Preceded by: Ronald Reagan
Ancestry of George W. Bush – Bush Family Tree – ThoughtCo
Ancestry of George Walker Bush – Bush Family Tree. Other important individuals in the Bush family tree include the Spencer family that produced Diana, Princess of Wales, which makes George W. Bush a 17th cousin to Prince William of Wales. The great great great grandmother of President George W.
The Bush Family Tree – WSJ.com
The first Bush first lady was born in New York and raised in Rye, a Westchester County suburb. In 1941, she met George H. W. Bush at a dance in Greenwich, Conn. They married in January 1945. Barbara moved with George Bush as his career in the oil business and later politics took him …
Bush Family's First Christmas without George H. W. and
The Bush family is celebrating their first Christmas without President George H. W. and former First Lady Barbara Bush "George H.W. Bush was a man of the highest character and the best dad a
George W. Bush – Paintings, Age & Wife – Biography
The family moved to Houston in 1961, and George W. Bush was sent to Phillips Academy in Andover, Massachusetts. There he was an all-around athlete, playing baseball, basketball and football.
President George W. Bush – bushcenter.org
President Bush was born on July 6, 1946, in New Haven, Connecticut, to Barbara and George H.W. Bush – later the 41st President of the United States. In 1948, the family moved to Texas, where George W. Bush grew up in Midland and Houston.


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Will Shane Jones be crown prince or court jester?by Jane Clifton
New Zealand First's Shane Jones is riding a wave of hype, but this could prove a handicap.
But Energy Minister Judith Collins has resoundingly trumped Jones. Her shrewd commissioning of a report into petrol pricing has produced the most blindingly obvious conclusion since someone asked whether the world was still roughly spherical and popes still needed to be Catholic: petrol companies are price-gouging.
No one anywhere was knocked down with a feather. The report found petrol companies charge what they reckon they can get away with and then some, they don't pass on downward fluctuations in the global price, and only in places where there's the extra competition of Gull stations do they tone it down – just a bit.
Were the same exercise commissioned into other economically critical sectors' pricing, notably electricity, building and the supermarket duopoly, it would probably produce the same conclusion: that in our small economy, lack of viable competitors leads to dominant companies charging at will.
The question is: what do we do about it? Where a market is not working competitively, there are three available remedies. One is to stimulate further competition – which markets are supposed to do in the first place and governments are pants at. Or the state could nationalise the sector, but that's pricey and apt to freak out one's trading partners and wobble the currency. So the prevailing orthodoxy is to regulate, which is hard to do fairly and without unintended consequences. More pertinently, the current Government is EpiPen-carryingly allergic to regulating profitable companies.
So even "Crusher" Collins, with her unerring populist nose, has ordered a further options report that will kick the petrol issue to the post-election touchline. If the errant companies aren't voluntarily being more competitive by then, they'll be referred to the Commerce Commission, which is being given new powers over them.
The Opposition, with superficial common sense, argues the commission should be sicked onto the job right now. More seasoned observers familiar with the ways of big business know this is no threat. The headline "Commerce Commission Cracks Down" is only slightly more common than "Donald Trump Admits Error". It may be a bit mean to say our dominant businesses see the state's watchdogs and regulators as one big Morris dancing troupe wafting wet bus tickets instead of hankies, but it needs saying anyway.
Gouging and weirdness
Which curiously brings us back to the second worst-kept secret, Shane Jones. This sort of issue is right up his alley. As an Opposition Labour MP, he once launched a promising campaign to highlight the price-gouging of our two dominant supermarket chains, both of customers and of suppliers.
What followed was deeply weird. Shoppers, whenever asked, said, "Too right we're being gouged." Food and grocery businesses supplied compelling evidence that they were being gouged. But primo business lobby Business NZ, representing food and grocery suppliers and supermarkets, said Jones was wrong and the sector was robustly competitive. The commission had a preliminary look and said there was nothing that fell within its scope.
This was more a function of its long-outdated legislative parameters than of evidence of satisfactory competitiveness among supermarkets. In Australia and the UK, which have far more than two big grocery chains and much keener competition, regulators have imposed a number of restrictions to curtail exactly the same anti-competitive practices Jones highlighted as occurring here.
Jones simply ran into deep institutional inertia, because sectoral lack of competitiveness like this is damnably hard territory for policymakers. The process of remedying it generates typhoons of vested-interest lobbying, fearmongering, economic instability and that most pernicious of effects, lawyers' bills. The very act of signalling a review can imperil national productivity. Politicians hate legislating in this sort of din, and it absolutely terrifies public servants.
Jones found he couldn't even get wholehearted support from Labour colleagues for his message that shoppers and small businesses were being gouged. Whatever the prevailing Labour message was at the time, it wasn't that. Rather than bang on by himself, he lapsed into a sort of bemused sulk, came a distant third in the next leadership ballot and was rescued by National with a job offer to be Ambassador for Pacific Economic Development.
His righteous populist urges simmered on and are now a good fit with NZ First and set for a vigorous talking-up as the party advances on kingmaker status after September's election. NZ First is not squeamish about proposing tumultuous regulatory reforms. That's at least partly because it has yet to be in a position to form a government and having to carry any out.
But given that it's likely to be more than tail-end Charlie in the next – still probably National-led – government, Jones's pro-competition preoccupation is worthy of careful study by those sectors that – however contentedly – comprise just a few dominant players. Meat and dairy will also be under at least a rhetorical threat of regulation if/when NZ First enters the Beehive. The party advances a pro-regional stance with such hyperbole that those invested in Auckland's continuing to grow apace had also better bone up on Jones-speak.
Life in the Winston-ocracy
A common media and collegial criticism holds that Jones is lazy, but it may be fairer to say he was easily discouraged by Labour's "not your turn yet" caucus ethos. NZ First doesn't do democracy or seniority like that. It's a Winston-ocracy, in which Jones is now crown prince and sharing the wheel.
What's unproven is whether he has the crossover appeal the hype surrounding his candidacy supposes. On paper, he should engage National, Labour, grumpy, provincial, blokey and Waitakere Man voterdom. In practice, the media-generated excitement could be a handicap.
Voters abroad have rejected the commentariat's picks, preferring their discards. Jones's best bet may be to court mockery by playing up his naughty-video-watching past. Actual past groping hasn't impeded President Trump. British Labour's Jeremy Corbyn, near-universally mocked as a frowny old throwback, was just mass-cheered at Glastonbury and is now the muse behind a designer range of "Dad-wear".
This article was first published in the July 15, 2017 issue of the New Zealand Listener.
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