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|Migraine Disorders:
|Articles from Torino
Sat Jun 1 01:18:40 2019
|These are the 74 published articles about Migraine Disorders that originated from Torino during 2008-2019.
|Targeting MTHFR for the treatment of migraines. 2019
Rainero, Innocenzo / Vacca, Alessandro / Roveta, Fausto / Govone, Flora / Gai, Annalisa / Rubino, Elisa. ·a Headache Center, Department of Neuroscience "Rita Levi Montalcini" , University of Torino , Torino , Italy. ·Expert Opin Ther Targets · Pubmed #30451038.
ABSTRACT: INTRODUCTION: Migraine is a common neurovascular disorder classified by the World Health Organization as one of the most debilitating diseases. Migraine is a complex disease and is a consequence of an interaction between genetic, epigenetic and environmental factors. The MTHFR gene is one of the few replicated genetic risk factors for migraine and encodes an enzyme that is crucial for the folate and the methionine cycles. Individuals carrying the T allele of the MTHFR C677T polymorphism have increased plasma concentrations of homocysteine which leads to endothelial cell injury and alterations in coagulant properties of blood. Areas covered: This review focuses on the recent advances in genetics and the role of the MTHFR gene and homocysteine metabolism in migraine etiopathogenesis. The article summarizes the potential of targeting MTHFR and homocysteine for disease prevention. Expert opinion: Determination of MTHFR C677T polymorphisms as well as measurement of homocysteine concentrations may be useful to migraine patients, particularly those suffering from migraine with aura. Preliminary studies support the use of folate, vitamin B6 and vitamin B12 for the prevention of migraine. However, the results of these studies await replication in larger randomized controlled clinical trials.
|Estrogen, migraine, and vascular risk. 2018
Allais, Gianni / Chiarle, Giulia / Sinigaglia, Silvia / Airola, Gisella / Schiapparelli, Paola / Benedetto, Chiara. ·Women's Headache Center, Department of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy. email@example.com. · Women's Headache Center, Department of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy. ·Neurol Sci · Pubmed #29904828.
ABSTRACT: Migraine has a predilection for female sex and the course of symptoms is influenced by life stage (presence of menstrual cycle, pregnancy, puerperium, menopause) and use of hormone therapy, such as hormonal contraception and hormone replacement therapy. Hormonal changes figure among common migraine triggers, especially sudden estrogen drop. Moreover, estrogens can modulate neuronal excitability, through serotonin, norepinephrine, dopamine, and endorphin regulation, and they interact with the vascular endothelium of the brain. The risk of vascular disease, and ischemic stroke in particular, is increased in women with migraine with aura (MA), but the link is unclear. One hypothesis posits for a causal association: migraine may cause clinical or subclinical brain lesions following repeated episodes of cortical spreading depression (CSD) and a second hypothesis that may explain the association between migraine and vascular diseases is the presence of common risk factors and comorbidities. Estrogens can play a differential role depending on their action on healthy or damaged endothelium, their endogenous or exogenous origin, and the duration of their treatment. Moreover, platelet activity is increased in migraineurs women, and it is further stimulated by estrogens.This review article describes the course of migraine during various life stages, with a special focus on its hormonal pathogenesis and the associated risk of vascular diseases.
|Is Migraine Primarily a Metaboloendocrine Disorder? 2018
Rainero, Innocenzo / Govone, Flora / Gai, Annalisa / Vacca, Alessandro / Rubino, Elisa. ·Neurology I, Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15, Turin, 10126, Italy. firstname.lastname@example.com. · Neurology I, Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15, Turin, 10126, Italy. ·Curr Pain Headache Rep · Pubmed #29619630.
ABSTRACT: PURPOSE OF THE REVIEW: The goals of this review are to evaluate recent studies regarding comorbidity between migraine and different metabolic and endocrine disorders and to discuss the role of insulin resistance as a common pathogenetic mechanism of these diseases. RECENT FINDINGS: Recently, several studies showed that migraine is associated with insulin resistance, a condition in which a normal amount of insulin induces a suboptimal physiological response. All the clinical studies that used the oral glucose tolerance test to examine insulin sensitivity found that, after glucose load, there is in migraine patients a significant increase of both plasmatic insulin and glucose concentrations in comparison with controls. On the contrary, no association was found between migraine and type 2 diabetes, while type 1 diabetes seems to have a protective effect in the disease. Obesity and hypertension were shown to be risk factors for both episodic and chronic migraine. Metabolic syndrome has been recently associated mainly with migraine with aura and is now considered a risk factor also for medication overuse headache. Finally, a bidirectional association between migraine and hypothyroidism has been recently demonstrated, suggesting that common genetic or autoimmune mechanisms underlie both diseases. Recent studies showed that insulin receptor signaling and the related physiological responses are altered in migraine and may have a relevant pathogenic role in the disease. Further studies are warranted in order to better elucidate mechanisms underlying insulin resistance in migraine in order to develop new therapeutic strategies for this debilitating disease.
|Menstrual migraine: a review of current and developing pharmacotherapies for women. 2018
Allais, G / Chiarle, Giulia / Sinigaglia, Silvia / Benedetto, Chiara. ·a Department of Gynecology and Obstetrics , University of Turin, Women's Headache Center , Turin , Italy. ·Expert Opin Pharmacother · Pubmed #29212383.
ABSTRACT: INTRODUCTION: Migraine is one of the most common neurological disorders in the general population. It affects 18% of women and 6% of men. In more than 50% of women migraineurs the occurrence of migraine attacks correlates strongly with the perimenstrual period. Menstrual migraine is highly debilitating, less responsive to therapy, and attacks are longer than those not correlated with menses. Menstrual migraine requires accurate evaluation and targeted therapy, that we aim to recommend in this review. AREAS COVERED: This review of the literature provides an overview of currently available pharmacological therapies (especially with triptans, anti-inflammatory drugs, hormonal strategies) and drugs in development (in particular those acting on calcitonin gene-related peptide) for the treatment of acute migraine attacks and the prophylaxis of menstrual migraine. The studies reviewed here were retrieved from the Medline database as of June 2017. EXPERT OPINION: The treatment of menstrual migraine is highly complex. Accurate evaluation of its characteristics is prerequisite to selecting appropriate therapy. An integrated approach involving neurologists and gynecologists is essential for patient management and for continuous updating on new therapies under development.
|Treating migraine with contraceptives. 2017
Allais, Gianni / Chiarle, Giulia / Sinigaglia, Silvia / Airola, Gisella / Schiapparelli, Paola / Bergandi, Fabiola / Benedetto, Chiara. ·Department of Surgical Sciences, Women's Headache Center, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy. firstname.lastname@example.com. · Department of Surgical Sciences, Women's Headache Center, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy. ·Neurol Sci · Pubmed #28527064.
ABSTRACT: At least 18% of women suffers from migraine. Clinically, there are two main forms of migraine: migraine with aura (MA) and migraine without aura (MO) and more than 50% of MO is strongly correlated to the menstrual cycle. The high prevalence of migraine in females, its correlation with the menstrual cycle and with the use of combined hormonal contraceptives (CHCs) suggest that the estrogen drop is implicated in the pathogenesis of the attacks. Although CHCs may trigger or worsen migraine, their correct use may even prevent or reduce some forms of migraine, like estrogen withdrawal headache. Evidence suggested that stable estrogen levels have a positive effect, minimising or eliminating the estrogenic drop. Several contraceptive strategies may act in this way: extended-cycle CHCs, CHCs with shortened hormone-free interval (HFI), progestogen-only contraceptives, CHCs containing new generation estrogens and estrogen supplementation during the HFI.
|Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine. 2016
Allais, Gianni / Benedetto, Chiara. ·Department of Surgical Sciences, Women's Headache Center, University of Turin, Turin, Italy. ·Drug Des Devel Ther · Pubmed #27757013.
ABSTRACT: Migraine is a common neurovascular disorder, affecting millions of people worldwide. Current guidelines recommend triptans as first-line treatment for moderate-to-severe migraine attacks. Frovatriptan is a second-generation triptan with a longer terminal elimination half-life in blood than other triptans (~26 hours). Three double-blind, randomized crossover preference studies have been recently conducted, assessing efficacy and safety of frovatriptan versus rizatriptan, zolmitriptan, and almotriptan, respectively. Frovatriptan showed favorable tolerability and sustained effect, with a significantly lower rate of relapse over 48 hours versus the other triptans. These findings were confirmed in a series of analyses of patient subsets from the three studies, including patients with menstrually related and oral contraceptive-induced migraine, hypertension, obesity, weekend migraine, as well as patients with migraine with aura. In all patient subsets analyzed, lower headache recurrence rates were observed versus the comparator triptans, indicating a more sustained pain-relieving effect on migraine symptoms. A further randomized, double-blind study demonstrated that frovatriptan given in combination with the fast-acting cyclooxygenase inhibitor dexketoprofen provided improved migraine pain-free activity at 2 hours, and gave more sustained pain-free activity at 24 hours, versus frovatriptan alone. These benefits were observed both when the combination was administered early (<1 hour after symptom onset) or late (>1 hour after onset). Different pharmacokinetic, but synergistic, properties between frovatriptan and dexketoprofen may make the combination of these agents particularly effective in migraine treatment, with rapid onset of action and sustained effect over 48 hours. These benefits, together with potential cost-effectiveness advantages versus other triptans could drive selection of the most appropriate treatment for acute migraine attacks.
|The use of progestogen-only pill in migraine patients. 2016
Allais, Gianni / Chiarle, Giulia / Bergandi, Fabiola / Benedetto, Chiara. ·a Department of Surgical Sciences, Women's Headache Center , University of Turin , Turin , Italy. ·Expert Rev Neurother · Pubmed #26630354.
ABSTRACT: Migraine is a debilitating neurovascular disorder which is estimated to affect 18% of women and 6% of men. Two main forms of this neurological disorder must be considered: Migraine without Aura and Migraine with Aura. Migraine without aura often has a strict menstrual relationship: the International Headache Society classification gives criteria for Pure Menstrual Migraine and Menstrually Related Migraine. The higher prevalence of migraine among women suggests that this sex difference probably results from the trigger of fluctuating hormones during the menstrual cycle. Safe and effective contraception is essential for all women of childbearing age, but Combined Oral Contraceptives have been associated with worsening of attacks and cardiovascular risk in these patients. We analyzed characteristics, effects and benefits of progestogen-only pill, a possible alternative for contraception in women with migraine.
|Migraine in perimenopausal women. 2015
Allais, G / Chiarle, G / Bergandi, F / Benedetto, C. ·Department of Surgical Sciences, Women's Headache Center, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy, firstname.lastname@example.com. ·Neurol Sci · Pubmed #26017518.
ABSTRACT: Hormonal changes during the reproductive cycle are thought to account for the variation in migraine occurrence and intensity. Although the majority of women and the specialists treating them do not consider migraine as a component of the climacteric syndrome, many women, in fact, do experience migraine during perimenopause. If a woman already suffers from migraine, the attacks often worsen during menopausal transition. Initial onset of the condition during this period is relatively rare. Women with the premenstrual syndrome (PMS) prior to entering menopause are more likely to experience, during late menopausal transition, an increased prevalence of migraine attacks. Hormone replacement therapy (HRT) can be initiated during the late premenopausal phase and the first years of postmenopause to relieve climacteric symptoms. The effect of HRT on migraine, either as a secondary effect of the therapy or as a preventive measure against perimenopausal migraine, has been variously investigated. HRT preparations should be administered continuously, without intervals, to prevent sudden estrogen deprivation and the migraine attacks that will ensue. Wide varieties of formulations, both systemic and topical, are available. Treatment with transdermal patches and estradiol-based gels is preferable to oral formulations as they maintain constant blood hormone levels. Natural menopause is associated with a lower incidence of migraine as compared with surgical menopause; data on the role of hysterectomy alone or associated with ovariectomy in changing the occurrence of migraine are till now unclear.
|Migraine and depression comorbidity: antidepressant options. 2012
Torta, R / Ieraci, V. ·Clinical and Oncologic Psychology Unit, University of Turin, Turin, Italy. email@example.com ·Neurol Sci · Pubmed #22644185.
ABSTRACT: Migraine and mood depression demonstrate a high clinical relation and share, also with pain, neurobiological mechanisms, particularly neuro-transmettitorial and phlogistic ones. The choice of an antidepressant to treat both depression and migraine is determined by its efficacy, safety, and tolerability. Antidepressants share comparable effectiveness for the treatment of depressive disorders, but their efficacy on headache varies widely: Tricyclic antidepressants are more effective than SNRIs and SSRIs, but demonstrate dose-limiting side effects.
|Premenstrual syndrome and migraine. 2012
Allais, Gianni / Castagnoli Gabellari, Ilaria / Burzio, Chiara / Rolando, Sara / De Lorenzo, Cristina / Mana, Ornella / Benedetto, Chiara. ·Department of Gynecology and Obstetrics, Women's Headache Center, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy. firstname.lastname@example.com ·Neurol Sci · Pubmed #22644184.
ABSTRACT: Premenstrual syndrome (PMS) includes a wide variety of physical, psychological, and cognitive symptoms that occur recurrently and cyclically during the luteal phase of the menstrual cycle and disappear soon after the onset of menstruation. Headache, often of migrainous type, is one of physical symptoms often reported in the diagnostic criteria for PMS. Menstrual migraine (MM) is a particular subtype of migraine occurring within the 2 days before and the 3 days after the onset of menses. According to this definition, therefore, some attacks of MM certainly occur in conjunction with the period of maximum exacerbation of PMS symptoms. The relationship between MM and PMS has been investigated through diary-based studies which have confirmed the possible correlation between these two conditions. In this paper we provide indications for the treatment of MM, making particular reference to those therapies that may be useful in the treatment of PMS symptoms. Even if triptans are the gold standard for the acute treatment, if symptomatic treatment is not sufficient one can resort to a short-term perimenstrual prophylaxis. Non-steroidal anti-inflammatory drugs have been demonstrated effective in MM prophylaxis. Among natural products there is some evidence of efficacy for magnesium, phytoestrogens, and ginkgolide B. Finally, also a combined oral contraceptive containing drospirenone, taken continuously for 168 days, has shown promising results.
|Evaluation of the use of sumatriptan-naproxen sodium for menstrual migraine and dysmenorrhea. 2011
Allais, Gianni / Castagnoli Gabellari, Ilaria / Rolando, Sara / Benedetto, Chiara. ·Women's Headache Centre, Department of Gynecology and Obstetrics, University of Turi, Via Ventimiglia 3, Torino, IT-10126, Italy. email@example.com ·Expert Rev Neurother · Pubmed #21955195.
ABSTRACT: Menstrual migraine (MM) is a form of headache that tends to occur with prolonged, intense and extremely disabling attacks in a short period around the menstrual cycle (usually 2 days before to 3 days after the onset of the menstrual flow). At least 50% of the female migraine population suffers from this subtype of migraine. The possible presence of other perimenstrual pain, such as dysmenorrhea, can make the attacks even more disabling. Since both of these conditions have a common pathological background consisting of a secretion of abnormally high levels of prostaglandins, it can be particularly useful to use a combination of sumatriptan, the progenitor of the triptans and the drug of choice in the treatment of migraine attack, and naproxen sodium, a potent inhibitor of prostaglandin biosynthesis. The combination of sumatriptan 85 mg and naproxen sodium 500 mg has been tested in women suffering from MM and dysmenorrhea, and this combination has been shown to achieve greater satisfaction when compared with placebo. Moreover, sumatriptan-naproxen was also better than placebo in reducing functional disability and improving productivity. The study is discussed in the context of the current state of knowledge about MM treatment.
|Do we need a new procedure for the assessment of adverse events in anti-migraine clinical trials? 2011
Amanzio, Martina. ·Department of Psychology and Neuroscience Institute of Torino (NIT), University of Torino, Via Verdi 10, 10123 Torino, Italy. firstname.lastname@example.com ·Recent Pat CNS Drug Discov · Pubmed #21118096.
ABSTRACT: The large number of randomized controlled clinical trials on migraine have drawn the attention of some authors to the need to improve the design of such trials. In particular, adequate methodology is a critical issue in their planning and execution, as different methodological approaches can translate into different results. The side-effects observed in both the active medication arm and the placebo arm--considering anti-migraine randomized clinical trials--are often influenced by non specific factors. This issue can be quantified by using a systematic review approach to study the rates of adverse events reported in the placebo arms of clinical trials. Such a study requires increased standardization of the methods used to collect adverse data in clinical trials. This focused review article provides a critical re-analysis of the results obtained, by our group, in a recent systematic review of adverse events reported in the placebo groups of clinical trials for three classes of anti-migraine drugs: NSAIDs, triptans and anticonvulsants [Amanzio et al., 2009]. We consider the need for caution in interpreting side-effect profiles of the different placebo groups. In particular, since the side-effects observed in both the active medication and placebo arms of randomized clinical trials are often influenced by patients' and investigators' expectations, the nocebo phenomenon may help to understand the occurrence of (adverse) non-specific side effects observed in these groups. We also discuss the importance of evaluating the role of contributing factors in the results obtained, such as the need for the examiner to be blind to the expected side-effects of the drug being evaluated and a better rationalization of informed consent in order to avoid the occurrence of negative expectations in patients, aimed at preventing negative expectation effects among both investigators and patients. Currently, there is one patented design for investigating reductions in the placebo effect in controlled clinical trials. This paper discusses how these ideas may be helpful in the assessment of adverse events in active and placebo groups.
|Non-pharmacological approach to migraine prophylaxis: part II. 2010
Schiapparelli, Paola / Allais, Gianni / Castagnoli Gabellari, Ilaria / Rolando, Sara / Terzi, Maria Grazia / Benedetto, Chiara. ·Department of Gynecology and Obstetrics, Women's Headache Center, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy. ·Neurol Sci · Pubmed #20464605.
ABSTRACT: Acupuncture has been used to both prevent and treat diseases for over 3,000 years. Recently, a Cochrane review on its use in migraine concluded that acupuncture is effective and should be considered as a prophylactic measure for patients with frequent or insufficiently controlled migraine attacks. In contrast, there is no clear evidence to support or refute the use of homeopathy in the management of migraine. Among vitamins and other supplements, riboflavin and coenzyme Q10 significantly decreased the frequency of migraine attacks. Alpha lipoic acid also reduced migraine frequency, albeit not significantly as compared to placebo. The prophylactic efficacy of magnesium, particularly for children and menstrually related migraine, has recently been substantiated. Among the herbal remedies, butterbur significantly decreases attack frequency, whereas the efficacy of feverfew was not confirmed in a Cochrane review, probably because of the 400% variations in the dosage of its active principle. Finally, ginkgolide B has proved significantly effective in controlling migraine with aura and pediatric migraine in uncontrolled studies that need a confirmation.
|Non-pharmacological management of migraine during pregnancy. 2010
Airola, Gisella / Allais, Gianni / Castagnoli Gabellari, Ilaria / Rolando, Sara / Mana, Ornella / Benedetto, Chiara. ·Department of Gynecology and Obstetrics, Women's Headache Center, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy. ·Neurol Sci · Pubmed #20464586.
ABSTRACT: Migrainous women note a significant improvement in their headaches during pregnancy. However, persistent or residual attacks need to be treated, keeping in mind that many drugs have potential dangerous effects on embryo and foetus. It is evident, therefore, that hygiene and behaviour measures capable of ensuring the best possible well-being (regular meals and balanced diet, restriction of alcohol and smoking, regular sleeping pattern, moderate physical exercise and relaxation) are advisable during pregnancy. Among non-pharmacological migraine prophylaxis only relaxation techniques, in particular biofeedback, and acupuncture have accumulated sufficient evidence in support of their efficacy and safety. Some vitamins and dietary supplements have been proposed: the prophylactic properties of magnesium, riboflavin and coenzyme Q10 are probably low, but their lack of severe adverse effects makes them good treatment options.
|The risks of women with migraine during pregnancy. 2010
Allais, Gianni / Gabellari, Ilaria Castagnoli / Borgogno, Paola / De Lorenzo, Cristina / Benedetto, Chiara. ·Women's Headache Center, Department of Gynecology and Obstetrics, University of Turin, Via Ventimiglia 3, 10126, Turin, Italy. firstname.lastname@example.com ·Neurol Sci · Pubmed #20464585.
ABSTRACT: Most epidemiological studies demonstrate that women suffering from migraine note a significant improvement in their headaches during pregnancy. Both headache specialists and gynecologists commonly hold that migraine does not involve any risks to either the mother, or the fetus. Despite this, recent studies into the medical complications of pregnancy in migrainous women have cast doubts on this assumption. Indeed, most of these studies have revealed a significant association between migraine and hypertension in pregnancy (i.e. preeclampsia and gestational hypertension). Migraine has also been recently postulated as one of the major risk factors for stroke during pregnancy and the puerperium. Therefore, there is an urgent need for prospective studies on large numbers of pregnant women to determine the real existence and extent of the risks posed by migraine during pregnancy. In the meantime, while awaiting verification of this hypothesis, a pregnant woman with migraine must be subject to a particularly attentive screening by both the obstetrician and the headache specialist.
|A systematic review of adverse events in placebo groups of anti-migraine clinical trials. 2009
Amanzio, Martina / Corazzini, Luca Latini / Vase, Lene / Benedetti, Fabrizio. ·Department of Psychology, University of Turin, Via Verdi 10, 10123 Turin, Italy. email@example.com ·Pain · Pubmed #19781854.
ABSTRACT: In analgesic clinical trials, adverse events are reported for the painkiller under evaluation and compared with adverse events in the placebo group. Interestingly, patients who receive the placebo often report a high frequency of adverse events, but little is understood about the nature of these negative effects. In the present study, we compared the rates of adverse events reported in the placebo arms of clinical trials for three classes of anti-migraine drugs: NSAIDs, triptans and anticonvulsants. We identified 73 clinical trials in 69 studies describing adverse events in placebo groups: 8 were clinical trials with NSAIDs, 56 were trials with triptans, and 9 were trials with anticonvulsants. Studies were selected of all Medline/PubMed or CENTRAL referenced trials published until 2007. Adverse event profiles of the three classes were compared using a systematic review approach. We found that the rate of adverse events in the placebo arms of trials with anti-migraine drugs was high. In addition, and most interestingly, the adverse events in the placebo arms corresponded to those of the anti-migraine medication against which the placebo was compared. For example, anorexia and memory difficulties, which are typical adverse events of anticonvulsants, were present only in the placebo arm of these trials. These results suggest that the adverse events in placebo arms of clinical trials of anti-migraine medications depend on the adverse events of the active medication against which the placebo is compared. These findings are in accordance with the expectation theory of placebo and nocebo effects.
|Perceptive aspects of visual aura. 2009
Aleci, Carlo / Liboni, William. ·Ophthalmology Department, Gradenigo Hospital, Cso R Margherita 8, 10153 Turin, Italy. firstname.lastname@example.com ·Neurol Sci · Pubmed #19779857.
ABSTRACT: Visual aura is the most common feature associated with migraine, though it can occur separately. In both cases it often represents a dramatic event, especially for patients who experience it for the first time. Besides, its subjective characteristics may illuminate on the functional architecture of the visual cortex. Repetitive events of migraine and visual aura have been suggested to affect the visual system in the long run, both on the cortical and precortical level. In effect, objective investigation of visual functions in patients support the idea that a selective damage does occur, so that more attention to visual examination seems to be justified. In this paper, subjective and psychophysical aspects of visual aura are examined, lastly highlighting and discussing the interesting correlations found between this condition and normal-tension glaucoma.
|Oral contraceptives in migraine. 2009
Allais, Gianni / Gabellari, Ilaria Castagnoli / De Lorenzo, Cristina / Mana, Ornella / Benedetto, Chiara. ·Department of Gynecology and Obstetrics, Women's Headache Center, University of Turin, Turin, Italy. firstname.lastname@example.com ·Expert Rev Neurother · Pubmed #19271947.
ABSTRACT: Combined oral contraceptives are a safe and highly effective method of birth control, but they can also raise problems of clinical tolerability and/or safety in migraine patients. It is now commonly accepted that, in migraine with aura, the use of combined oral contraceptives is always contraindicated, and that their intake must also be suspended by patients suffering from migraine without aura if aura symptoms appear. The newest combined oral contraceptive formulations are generally well tolerated in migraine without aura, and the majority of migraine without aura sufferers do not show any problems with their use; nevertheless, the last International Classification of Headache Disorders identifies at least two entities evidently related to the use of combined oral contraceptives: exogenous hormone-induced headache and estrogen-withdrawal headache. As regards the safety, even if both migraine and combined oral contraceptive intake are associated with an increased risk of ischemic stroke, migraine without aura per se is not a contraindication for combined oral contraceptive use. Other risk factors (tobacco use, hypertension, hyperlipidemia, obesity and diabetes) must be carefully considered when prescribing combined oral contraceptives in migraine without aura patients, in particular in women aged over 35 years. Furthermore, the exclusion of a hereditary thrombophilia and of alterations of coagulative parameters should precede any decision of combined oral contraceptive prescription in migraine patients.
|The diagnostic iter of patent foramen ovale in migraine patients: an update. 2008
Liboni, William / Molinari, Filippo / Chiribiri, Amedeo / Allais, Gianni / Mana, Ornella / Negri, Emanuela / Grippi, Gianfranco / Giacobbe, Massimiliano / Badalamenti, Sergio / Benedetto, Chiara. ·Department of Neuroscience, Gradenigo Hospital, Turin, Italy. ·Neurol Sci · Pubmed #18545889.
ABSTRACT: Patent foramen ovale (PFO) is a frequent finding in migraine patients. The standard technique for PFO diagnosis is actually trans-oesophageal echocardiography (TEE). It requires the injection of a contrast agent unable to pass the pulmonary filter; hence, it is possible to detect a right-to-left shunt by observing the presence of the contrast medium in the cardiac left compartment. The transcranial Doppler (TCD) device accurately measures the blood flow velocities in different cerebral arteries. It can record microembolic signals (MES) backscattered by microbubbles travelling in the cerebral circulation, and distinguish cardiac shunts from pulmonary shunts. The number of MES is correlated to the entity of the shunt. The near-infrared spectroscopy (NIRS) technique tracks the changes in the concentration of oxygenated and reduced haemoglobin in the brain tissue. PFO is revealed by an alteration of the normal vasoreactivity pattern of the subject during functional stimuli. Magnetic resonance imaging (MRI) provides, at the same time, detailed anatomical information and functional measurements. MRI dynamic perfusion sequences can be used to reliably detect PFO either by visual assessment or by signal-time curves in the pulmonary artery and in the left atrium. A good correlation between TEE and MRI grading scores has been demonstrated, even though the interindividual variability of performing the Valsalva manoeuvre could greatly reduce the sensitivity of the method. Further prospective studies are needed to confirm the PFO MRI grading and to assess the sensitivity and specificity of the method.
|Migraine and stroke: the role of oral contraceptives. 2008
Allais, Gianni / Gabellari, Ilaria Castagnoli / Mana, Ornella / Schiapparelli, Paola / Terzi, Maria Grazia / Benedetto, Chiara. ·Women's Headache Center Department of Gynecology and Obstetrics, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy. email@example.com ·Neurol Sci · Pubmed #18545887.
ABSTRACT: The use of oral contraceptives (OCs) confers an increased risk for ischaemic stroke (IS). This risk slightly decreases, but remains significant, if low-dose formulations are used, particularly if other risk factors, such as hypertension or smoking, are associated. Some inherited prothrombotic conditions (e.g., Factor V Leiden, G20210A prothrombin or methylenetetrahydrofolate reductase C677T polymorphism) could also greatly increase the IS risk if present in OC users. Migraine, particularly with aura, is an independent risk factor for IS, and the patient's IS risk is probably affected by other individual risk factors (e.g., age, genetic predisposition to thrombosis, presence of patent foramen ovale or enhanced platelet aggregation) which seem to be over-represented in migraine patients. IS risk among migraineurs is further increased when OCs are currently used and can become very high if associated with smoking. Consequently, in 2004 the WHO stated in its 'Medical Eligibility Criteria for Contraceptive Use' that women suffering from migraine with aura at any age should never use OCs. Moreover, since the exposure to the effects of OCs may greatly increase the IS risk in some migraine subpopulations with specific personal characteristic, testing for these risk factors may allow for more accurate stratification of the population at risk before long-term use of OCs is prescribed.
|Hypocretins and primary headaches: neurobiology and clinical implications. 2008
Rainero, Innocenzo / De Martino, Paola / Pinessi, Lorenzo. ·Neurology II - Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15-10126, Torino, Italy. firstname.lastname@example.com ·Expert Rev Neurother · Pubmed #18345971.
ABSTRACT: Hypocretins (or orexins) are two neuropeptides synthesized by neurons located exclusively in the hypothalamus. Hypocretin-containing neurons have widespread projections throughout the CNS; with particularly dense excitatory projections to monoaminergic and serotonergic brainstem centers. The hypocretin system influences a wide range of physiological processes in mammals, such as feeding, arousal, rewards and drug addiction. Recently, a number of studies in experimental animals showed that hypocretins are involved in pain modulation within the CNS, and suggested the presence of a link between these peptides and nociceptive phenomena observed in primary headaches. The aim of this review is to describe and discuss recent studies in humans suggesting a role for the hypocretin neuronal system in cluster headache and chronic migraine.
|Clinical Trial
|Frovatriptan plus dexketoprofen in the treatment of menstrually related migraine: an open study. 2013
Allais, Gianni / Rolando, Sara / Schiapparelli, Paola / Airola, Gisella / Borgogno, Paola / Mana, Ornella / Benedetto, Chiara. ·Women's Headache Center, Department of Gynecology and Obstetrics, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy. firstname.lastname@example.com ·Neurol Sci · Pubmed #23695075.
ABSTRACT: At least 50 % of female migraineurs experience migraine associated with the perimenstrual period, even though they may also suffer from attacks at other times of the cycle (menstrually related migraine, MRM). MRM attacks tend to be longer and more intense than those arising in other phases of the menstrual cycle, and are often aggravated by more pronounced vegetative phenomena. In this open preliminary trial, we tested the efficacy of associating frovatriptan and dexketoprofen for the treatment of an acute attack of MRM, diagnosed according to the criteria of the International Headache Society, in 24 patients between 19 and 45 years of age (mean 31.33 ± 7.33). Twenty-one of them completed the study. Pain relief was achieved by 76 % of patients at 2 h and by 86 % at 4 h. A pain-free state was achieved by 48 % at 2 h and by 62 % at 4 h from taking the product. A pain-free state at 24 h was present in 76 % of MRM sufferers, 33 % of whom showed a sustained pain-free state at 24 h. A rescue medication was needed by eight patients. While decidedly encouraging, the data of this study obviously need confirmation with double blind studies involving a greater number of patients.
|Clinical Trial
|The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial. 2013
Allais, Gianni / D'Andrea, Giovanni / Maggio, Maurizio / Benedetto, Chiara. ·Department of Gynecology and Obstetrics, Women's Headache Center, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy. email@example.com ·Neurol Sci · Pubmed #23695070.
ABSTRACT: In this open trial we evaluated the possible efficacy of Ginkgolide B in the treatment of acute aura in a group of patients suffering from migraine with aura, considering in particular the effect of the treatment on aura duration. Twenty-five patients (16 females, 9 males, mean age 39.7 ± 13.5 years, range 18-65) suffering from migraine with aura were enrolled in the study. The diagnosis was made according to the diagnostic criteria of the international classification of headache disorders, second edition (ICHD-II), for typical aura with migraine headache (n = 19) or typical aura without headache (n = 6). Patients were asked to use a diary card to register the exact duration of the aura symptoms in two consecutive attacks of aura. In the first one, they only took note of the duration of neurological symptoms in minutes. In the following attack, they were instructed to take orally, immediately at the onset of the first symptoms of aura, two capsules of a combination of 60 mg Ginkgo biloba terpenes phytosome, 11 mg coenzyme Q 10 and 8.7 mg vitamin B2 (Migrasoll). Aura duration (expressed in minutes) was significantly (p < 0.001) reduced by Migrasoll intake, being 33.6 ± 11.5 in the first untreated attack and 21.9 ± 11.8 during the second attack. In general, there was a marked amelioration of the features of the neurological symptoms of aura in the treated attack. In four patients (18.1 %) suffering from typical aura with migraine, the pain phase disappeared. Among the patients who completed the study no serious adverse events were reported.
|Clinical Trial
|Perimenstrual migraines and their response to preventive therapy with topiramate. 2011
Allais, Gianni / Sanchez del Rio, Margarita / Diener, Hans-Christoph / Benedetto, Chiara / Pfeil, Joop / Schäuble, Barbara / van Oene, Joop. ·Women's Headache Center, Department of Gynecology and Obstetrics, University of Turin, Italy. firstname.lastname@example.com ·Cephalalgia · Pubmed #20650999.
ABSTRACT: INTRODUCTION: Preventive treatment with topiramate is effective for overall reduction of migraine frequency, but there are few data regarding its efficacy on perimenstrual migraines. To determine whether topiramate can prevent perimenstrual migraines, we analyzed data from premenopausal women as a subgroup of the Prolonged Migraine Prevention with Topiramate (PROMPT) study. METHODS: In total, 198 women from the PROMPT study with menstrually related migraine (MRM) were evaluated. After a one-to-two-month prospective baseline period, patients received open-label topiramate (50-200 mg/day) for six months. RESULTS: During topiramate treatment, mean monthly migraine frequency was reduced from 7.03 at baseline to 4.36 (mean change: -2.66; p < .001, endpoint analysis). Mean percentage reductions were similar for migraines during and outside the perimenstrual period (-45.9% and -46.1%, respectively). In patients with aura, reductions in migraine days with (-48.3%) or without (-43.4%) aura were similar to those in patients without aura (-45.4%). Reductions were also similar whether women were taking combined oral contraceptives (-47.0%) or were not (-46.6%). CONCLUSIONS: Topiramate reduces the frequency, but not severity or duration, of perimenstrual migraines in women with MRM, including migraines with and without aura, and regardless of combined oral contraceptive use.
|Clinical Trial
|Oral contraceptive-induced menstrual migraine. Clinical aspects and response to frovatriptan. 2008
Allais, Gianni / Bussone, Gennaro / Airola, Gisella / Borgogno, Paola / Gabellari, Ilaria Castagnoli / De Lorenzo, Cristina / Pavia, Elena / Benedetto, Chiara. ·Women's Headache Center Department of Gynecology and Obstetrics, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy. firstname.lastname@example.com ·Neurol Sci · Pubmed #18545931.
ABSTRACT: Oral contraceptive-induced menstrual migraine (OCMM) is a poorly defined migraine subtype mainly triggered by the cyclic pill suspension. In this pilot, open-label trial we describe its clinical features and evaluate the efficacy of frovatriptan in the treatment of its acute attack. During the first 3 months of the study 20 women (mean age 32.2+/-7.0, range 22-46) with a 6-month history of pure OCMM recorded, in monthly diary cards, clinical information about their migraine. During the 4th menstrual cycle they treated an OCMM attack with frovatriptan 2.5 mg. The majority of attacks were moderate/severe and lasted 25-72 h or more, in the presence of usual treatment. Generally an OCMM attack appeared within the first 5 days after the pill suspension, but in 15% of cases it started later. After frovatriptan administration, headache intensity progressively decreased (2.4 at onset, 1.6 after 2 h, 1.1 after 4 h and 0.8 after 24 h; p=0.0001). In 55% of patients pain relief was reported after 2 h. Ten percent of subjects were pain-free subjects after 2 h, 35% after 4 h and 60% after 24 h (p=0.003 for trend); 36% relapsed within 24 h. Rescue medication was needed by 35% of patients; 50% of frovatriptan-treated required a second dose. Concomitant nausea and/or vomiting, photophobia and phonophobia decreased significantly after drug intake. OCMM is a severe form of migraine; actually its clinical features are not always exactly identified by the ICHD-II classification. However, treatment with frovatriptan 2.5 mg might be effective in its management.


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How do you fix a broken hood latch on a 1991 Oldsmobile Cutlass Supreme and where is the latch underneath the hood?
I would go to a wrecking yard and look at the same type of vehicle and fashion a homemade tool device to jimmy the hood open,. The latch is located in front of the radaiator, I would look around the neighborhood for another GM car of that vintage to familiarize myself... .
I've got a '93 Cutlass Supreme, and judging by the body style I don't imagine much has changed. I was able to get my hood open by hand, no tool required. In between the radiator and the front bumper is a space that will allow you to access the latch. All that you can see from this angle is the spring that secures the latch when you close the hood, but you can feel the mechanism. If you push back the plastic that backs the bumper, you can even see the wire (in its plastic casing) that releases the hood.
By laying on the ground (feet toward the passenger side of the car), I was able to pull the latch open. The latch is spring loaded as well. It swings on a point near the hood itself. In order to release the latch, look for the end of the wire that pulls open the latch. If it's clean it will be bright aluminum. Unfortunately, the reason that it is probably stuck is that it is all gummed up with dirt and grime. You should be able to follow along the wire as I mentioned before and feel the end cap. Pull the lever that the wire is attached to toward the driver's side of the car. It may take some doing, but it should release the latch.
I haven't resolved the problem yet, but at least you can get the hood open. I know that a couple of years ago, my latch started to stick. I doused it with WD-40 and when it dried I coated it in white lithium grease. Unfortunately I think this only compounded the problem by providing a sticky surface for grime to build upon, which resulted in the latch getting too jammed to open by the regular method. I have cleaned it again with WD-40 and it appears to be OK. I will post more once I am sure I have actually got it in working order.
I too had this problem with my 92, if most everything is still intact. After you've done the things mentioned above by these helpful dudes. You may have jiggled it enough around (played with the inner mechanisms). You may try standing on the broke cable inside the car and with pliers er, whatever pull it again and then go try to lift the hood. Mine came open like that. Car had been giving me fits. So, i actually broke the inside lever twice. 1st one pulled the plastic piece off. second one broke the end of the wire, and tore it off the floor. Anger never helps, hah. Think things through is good advice.
1988 Oldsmobile cutlass supreme brake lights wont turn off?
The brake light switch must be broken or out of adjustment. The switch is located above the brake pedal. what if it don't cut off Read More
What would cause the blinkers to fail on a 1994 Oldsmobile cutlass ciera?
cracked or broken wiring, blown fuse Read More
Can a broken rear suspension leaf spring on a 1996 Oldsmobile cutlass supreme be easily replaced?
It isn't the easiest job, but it isn't terribly difficult either. A Haynes manual runs about $20 which you will easily make back if you use it one or two times. Read More
How do you fix an oil leak for a 1995 Oldsmobile Cutlass Supreme We think it's the o-ring but we're not sure please give all suggestions?
Not sure if this is your problem, but my 1996 Olds Cutlass Supreme leaked coolant into the oil. This was caused by broken intake manifold gasket. Apparently they're somewhat notorious for developing leaks. That repair required taking the top half of the engine apart. Not sure where your leak is, or how much it's leaking, but you may want to consider the intake manifold and head gaskets. Read More
How much would it cost to replace a broken head gasket on a 1995 Oldsmobile Cutlass Supreme?
The cost of the head gasket itself would be anywhere from approximately $20 - $40 per piece (there are two head gaskets, as 1995 Olds Cutlass Supreme has a V6 engine) depending on whether you have the 3.1L or 3.4L DOHC engine. Most of the cost will go to labor; it is a time-consuming job. Best to call a few shops to compare and get estimates on actual labor and parts prices. If anyone has… Read More
Why does your air conditioner turn the car off in your 1992 cutlass supreme?
It turns your 1992 car off when there is a problem, somethings broken, or it takes up to much of the battery/fuel. Read More
How do you open the hood when the inside hood release is broken on a 1990 Oldsmobile Cutlass Supreme?
On my 1988 Cutlass Supreme the cable broke at the release point in the car. I was unable to see anything from the outside so in the passenger compartment I took the release handle apart and used a set up pliers to pull the cable and release the hood. There should be just on bolt holding the release in place, it may be covered by the carpet. If it can't be done from the inside… Read More
Why does your 1986 Olds Cutlass Supreme have oil in the spark plugs?
oil on the spark plugs is generally due to broken ring or rings in the cylinder or cylinders can also lead to a blown engine Read More
Where would you find the routing of the hood release cable on a 1994 Cutlass Supreme Convertible?
Dealer said cable is run through a steel tube. They had to cut tube to replace broken cable. Read More
1992 Oldsmobile Achieva how do you hood if release cable is broken?
Go underneath the front of car by the grill.Look up towards the hood latch.In the middle is a switch.Push it to the left and the hood should release. Read More
Any suggestions on getting open the doors of a 1992 Olds Cutlass Supreme The handles are NOT broken however neither door will open from inside or out. The locks are fine and unlocked.?
crawl in from the trunk i do Read More
Why won't the top of your 1994 Oldsmobile Cutlass Supreme Convertible go up only the drivers side goes up but the passenger's side doesn't?
Most likely the heim joint has broken on the end of the ram's rod that pushes on the top. Originally pot metal. They screw on to the end of the ram and connect to the top's frame at the shoulder area. Can order new ones off eBay that are better quality and cheap. Read More
How do you release parking brake on 1997 olds cutlass supreme if emergency brake cable is broke?
If the cable is broken and parking/emergency brake is still ON, then they are rusted in place ! - Your emergency brake system needs urgent work. Read More
Why is water draining out underneath the house?
Broken supply line or drain. Crawl underneath and see which. Read More
What is broken on 1998 Oldsmobile silhouette when gearshift will no move out of neutral?
Shift cable Read More
What causes Oldsmobile aurora chime to stay on?
Door plunger switch broken or bad. Read More
Why wont power steering work on 1999 cutlass?
Loose or missing belt - Lack of fluid - broken pump Read More
Why is your 1999 Oldsmobile over heating after six miles?
your thermostat is probably broken get a new one Read More
Why does your 2001 Oldsmobile alero jerk while driving?
It's probably a broken engine mount. I have an 04 Alero and mine was broken. Jerking stopped when I replaced it. Read More
What causes the tail lights dash light AC panel light ashtray light and fog lights to stop working on a 1992 Oldsmobile Cutlass Ciera?
Check the fuses. If the fog lights are not factory original, someone may have overloaded a circut by adding them incorrectly. any frayed or broken wiring may need repair. try following the wires. Read More
How do you release the parking brake if the release cord is broken on a 1988 Oldsmobile Cutlass?
If you can't access the release lever on the brake pedal (where cable connects to emergency brake mechanism), you may have to go under vehicle and access the adjusting nut (where main cable from interior of vehicle connects to the individual wheel cables) and disconnect the main from wheel cables. Read More
What causes serpentine belt to run off crankshaft pulley 99 olds cutlass 3100?
Bent, Broken, or misaligned pulley Read More
What are the causes of brake light not working on a 2001 Oldsmobile Alero?
you either have a blown bulb or you have a broken wire Read More
Which Superchick album features a broken megaphone design?
Superchick's 2005 album, "Beauty from Pain", features a megaphone that appears broken underneath a white cover with a cut-out of a person holding a megaphone with the band's name underneath. See the Amazon page for pictures. == == Read More
How do you get into a 93 cutlass supreme from the outside when both of the door handles are broken?
Well both of mine broke off same car. I just loop something around what used to be part of my door handle and pull downward. Been doing this for over a year.. Sucks when I have to use my shoe because I forgot to bring a shoe string. =) Read More
Which court decides if laws have been broken at the national level?
The Supreme Court Read More
What is wrong when everytime you touch the gas in your 1989 Cutlass Supreme it dies what is wrong?
check the roder and cap you might hit the gas and it will flood the car because you dont have the spark that you need mine did the same thing as it turns out the choke spring was broken. put a new choke assy in it for 15 bucks runs like a top now. Read More
How do i rest the power window circuit breaker on a 1995 cutlass ciera?
The circuit breaker resets itself after it cools off, unless the breaker is broken. Read More
What kind of problem is a broken evap service port on a 1999 Oldsmobile alero going to give you?
check engine light Read More
On a 1995 Oldsmobile Cutlass Supreme why won't the engine start It isn't the battery or the starter you thought maybe it was the flywheel however you just wanted some other opinions Please help?
If the engine will not turn over, it is either the battery or the starter. Turn on the headlights and then have someone try to start the vehicle while you look at the headlights. If the lights go dim, the battery is bad. If they do not, you have a problem with the starter. Remove the starter and have it tested. The flywheel would only be the problem if you hear the starter engage and… Read More
How much would it cost to replace a broken head gasket on a 95 cutlass ciera?
Depends on where you live and who fixes it. Expect to pay at least $500 and up. Read More
Why will shifter knob on 1995 Olds Cutlass Supreme not shift from park have to remove knob to push down shaft to shift?
Generally, if the button on the shifter does not go in, there is a build-up of dirt and debris in the mechanism causing it not to move. A good amount of WD-40 or other lubricant usually helps the problem. If not, there is a good chance that the connector pin in the mechanism is either popped out or broken. Read More
What do you need to look for to find out why the speed odometer doesn't work on a 99 Oldsmobile intrigue?
Check the cable from the transmission, probably broken. Read More
Who were the gods of India?
Brahaman, was a supreme god and he was broken into 3 groups. Brahma, Vishnu Shiva Read More
Why is power steering fluid leeking from underneath your vehicle?
You have a broken hose or a blown seal in the steering system. Read More
How do you get the hood of a 1992 cutlass siera open when the hood latch cable is all the way back and not broken?
hold out on handle another person tap on frt. of the hood Read More
How do you replace broken antenna mast on 1993 Jeep Cherokee?
The antenna should just unscrew from the base. If the base is broken then usually there is a cover to take off and screws are underneath. If not then it is screwed on from underneath the fender. You might have to take the inner liner out or out of the way to get to them. Have seen jeep do several different ways over the years. I hope I have helped some. Read More
How do you get the rear of your 1997 Olds cutlass Supreme to quit squeaking?
Check the rear struts & upper mounting plates to see if you have a seized strut or worn or broken upper plate. Check the ends of the spring to see if the insulators are worn off and causing noises. Struts & upper mounts can be replaced & teflon blocks are available from Moog to take the place of the oem insulators Read More
What is meant by saying the constitution is the Supreme Law of the Land?
the constitution is a document where our laws are written. they cannot be broken Read More
How do you open the hood on a 97 buick lesabre when the latch is broken?
The best way to to try to find the cable and cut it and pull with pliers to open if the inside latch is broken. If not then you would have to go in from underneath or through the grill. Read More
How do you get into a 1997 olds cutlass supreme when both of the outer door handles break off because of the cold?
I have a 1997 Olds Cutlass Supreme and have been in your position several times! I have had to replace both door handles twice, and now the passenger side door is broken again. You *can* get into the car through the trunk--have someone who is small get into the trunk and push through the backseat (not sure if it's the same side in all the car, but mine pushes through on the driver's side of… Read More
Why does my Oldsmobile aurora shake at 50 Mph?
Maybe out of alignment........maybe tire out of balance or broken belt.....maybe broken strut or shock absorber........maybe loose or brokwn steering components......I could go on, but I think you get the idea. Read More
How do you unlock an Oldsmobile when keys are locked inside?
If the car can't be broken into without damaging something or breaking a window, best to call a professional locksmith. Read More
Rear speaker won't come on in my 1999 Oldsmobile alero?
If you can't make it to work with your fader and balance adjustment buttons, then it is broken and should be replaced. Read More
How do you open the hood on a 94 geo with a broken hood latch cable?
If it is just the inside handle broken off you can pull the cable with a pair of pliers. If it is in the middle, you should be able to reach up from underneath and cut the cable and then pull the inside cable. If the latch end has pulled off, you may be able to trip the latch from underneath, or take the grill out and unbolt the latch. Read More
How do you open the hood with cable broken located on a Oldsmobile Omega?
With a long ty-rap or 2 of them one around the lever and the otherone through it to form a handle. Read More
How do you disable a broken horn in a Nissan Maxima?
if your horn is stuck on makin noise pull the fuse out... or you can remove the whole horn assembly from underneath the hood Read More
Rover 400 parking break not working?
Check cables underneath. Sounds like 1 broken or came off end of pedal arm. Read More
Is there any way into the broken bow in Fallout 3 other than lockpicking?
Yes, if you go to the other side of the broken bow, you can swim underneath on the far left side. and you will find a door. 'beware' there are quite a bit of mirelurke hunters. Read More
How do you fix an blown gauge fuse in a Camaro 1991 RS?
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Collections Analyst
- Recruiter
- Hays A&F
- Location
- England, Leicestershire
- Salary
- £30000 - £32000.00 per annum
- Posted
- 16 May 2019
- Closes
- 13 Jun 2019
- Ref
- 3595298
- Contact
- Drew Semple
- Job Role
- Business Analyst
- Sector
- Not for Profit / Charity
- Contract Type
- Contract
- Hours
- Full-time
- Level of qualification
- Not qualified, Part qualified
Collections Analyst | Leicester | £32k FTC
The Role
Evaluate and analyse data with the objective of ensure consistent work flow and development of additional collection strategies to maximise collections through the consistent reduction of aged debt.
- Strong analytical and conceptual skills
- Capability to work effectively with Stakeholders and Senior Management
- Excellent oral and written communication skills, and experience of working with an internal cross-functional team.
- Experience in using standard Microsoft Office tools
- Ability to work at pace in a dynamic environment
- Data collection and interpretation
- Create and maintain Excel based models and dashboards
- Provide professional customer service to all areas of the business
- Excellent communications skills (written and verbal) with message alignment for the target audience.
- Ad hoc business improvement activities and data analysis
- An awareness of the tools and techniques associated and utilised in Business Analysis
- Have worked in a similar Business Analyst role
- ISEB or BCS certified business analyst
- Experience of collections and financial industry
- Customer volume analysis
- Cost recovery based on data analysis
What you need to do now
If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.
If this job isn't quite right for you but you are looking for a new position, please contact us for a confidential discussion on your career.
Hays Specialist Recruitment Limited acts as an employment agency for permanent recruitment and employment business for the supply of temporary workers. By applying for this job you accept the T&C's, Privacy Policy and Disclaimers which can be found at hays.co.uk


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Yusuf was good at his work but somehow my ac blower is now making a loud sound , which wasn't the case before servicing , I had asked the technician about it before leaving , he said it would go away its coz its wet may be , I'm not technically sound to judge why it's making the noise but my ac was quiet and brilliant before service I expect it to be the same if not better after the service.
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Service was excellent perfactly done by dem all AC . technician wear excellnt . After servicing last clining was not gudRead more reviews
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The Artist's Reality: Philosophies of Art (Paperback)Mark Rothko (author), Christopher Rothko (author of contributions,editor)
- In stock online
One of the most important artists of the twentieth century, Mark Rothko (1903-1970) created a new and impassioned form of abstract painting over the course of his career. Rothko also wrote a number of essays and critical reviews during his lifetime, adding his thoughtful, intelligent, and opinionated voice to the debates of the contemporary art world. Although the artist never published a book of his varied and complex views, his heirs indicate that he occasionally spoke of the existence of such a manuscript to friends and colleagues. Stored in a New York City warehouse since the artist's death more than thirty years ago, this extraordinary manuscript, titled The Artist's Reality, is now being published for the first time.
Probably written around 1940-41, this revelatory book discusses Rothko's ideas on the modern art world, art history, myth, beauty, the challenges of being an artist in society, the true nature of "American art," and much more. The Artist's Reality also includes an introduction by Christopher Rothko, the artist's son, who describes the discovery of the manuscript and the complicated and fascinating process of bringing the manuscript to publication. The introduction is illustrated with a small selection of relevant examples of the artist's own work as well as with reproductions of pages from the actual manuscript.
The Artist's Reality will be a classic text for years to come, offering insight into both the work and the artistic philosophies of this great painter.
Publisher: Yale University Press
Number of pages: 176
Weight: 363 g
Dimensions: 229 x 178 x 11 mm
"The rediscovered book manuscript . . . adds an important document to the literature of modern American art."-Kenneth Baker, San Francisco Chronicle
"The book is an enormously important art history document because, oddly, it is unsurprising. It confirms what the best critics have always seen in Rothko's work: the desire to go beyond the historical moment, beyond the accidental detail, beyond nation or culture, even the self, to arrive at a transcendent and universal experience, to arrive at, as he puts it, the myth."-Bryan Appleyard, Sunday Times Magazine
"The book broaches a poetics of space that would finally place Rothko's art among the more uncommon visual achievements of the 20th Century."-David Anfam, The Art Newspaper
"A deceptively slender volume. . . . Reflects the author's intense intellectual curiosity and ambition."-Phoebe Hoban, New York Times
". . . a remarkable book . . . it should be required reading for every teacher and every student of art history and philosophy of art."-The Art Book
"Rothko's book is fascinating . . . captur[ing] a moment of intense perception into the nature of art by one of its chief practitioners."-The Royal Academy Magazine
"The Artist's Reality will be a classic text for years to come, offering insight into both the work and the artistic philosophies of this great painter."-Antiques Magazine
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The truth is always best policy when selling.
Misrepresentation is always dangerous, but never more so than when selling expensive property.
Fraudulent misrepresentation can result in the seller being ordered to pay damages or to compensate the buyers for any consequential losses resulting from incorrect information given by the seller or anyone acting on their behalf.
There have been a number of recent cases that highlight the perils of being economical with the truth when selling property. In one case, the High Court awarded damages against a landlord for fraudulent misrepresentation even though the tenant was made aware of the existence of dry rot in the property before signing up for the lease.
In answer to enquiries from the tenant's solicitors about whether the property had been affected by dry rot at any time the landlord's solicitors said: "The vendor is not aware of such matters, however we suggest you make and rely upon your inspection and survey."
The court held the reply was a fraudulent misrepresentation.
It also included by implication a negligent misrepresentation that reasonable steps had been taken to establish whether dry rot existed after completion of the refurbishment.
Even though the tenant commissioned a survey yet chose to ignore the recommendation of its own surveyor to investigate the existence of dry rot in more detail, the high court decided the landlord was in the wrong.
In another case, the vendors sold a house in which a dreadful murder had taken place. The buyer's enquiries before contract included: "Is there any other information which you think the buyer may have a right to know?" The vendors answered "No".
They knew about the murder but considered they were under no obligation to disclose information relating to it to the buyer.
In this case the Court of Appeal agreed and dismissed the buyer's claim for misrepresentation.
The buyers had resold the house for pounds 75,000, instead of pounds 100,000, which would have been its value without the gruesome history.
It is wise to reveal as much as possible about a property to a potential buyer in writing. Remember that an incorrect representation can come back to haunt a seller if the buyer enters into a contract by relying on it.
In a third case, another simple question and answer resulted in substantial damages being paid by the seller. Here the sellers were asked: "Do you know of any disputes about this or any other property?"
The sellers replied "No", when in fact there had been a long-standing dispute about parking arrangements. Months after the purchase of the property completed these disputes came to light. The buyers claimed damages for fraudulent misrepresentation.
They successfully argued that they would not have bought the property had they known about the disputes. The sellers paid pounds 60,000 in damages and legal costs to the buyers.
Landlords and sellers need to be very cautious when replying to enquiries by using terms similar to "Not to the landlord's knowledge" or "Not so far as the landlord is aware". They imply that the landlord has taken reasonable steps to reach a reasoned conclusion.
The Seller's Property Information Form contains two questions about disputes, which have to be completed by the seller's solicitor.
These are: "Do you know of any disputes about this or any neighbouring property?" And: "Have you received any complaints about anything you have or have not done as owners?".
The form explains the importance of accurate answers. "Incorrect information given to the buyer through your solicitor, or mentioned to the buyer in conversation between you, may mean that the buyer can claim compensation from you or even refuse to complete the purchase".
Seller beware. Despite the clear instructions to tell the whole truth about a property, some sellers court danger with evasive answers that could cost them thousands of pounds ( and a possible sale.
Richard Freeman-Wallace is head of property at Watson Burton in Newcastle
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|The Journal (Newcastle, England)
|Nov 2, 2005
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