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European Projects
Co-design a resilience programme aimed at teenagers, families, professionals in the fields of education, and education centres to enhance the resilience capacity of teenagers.
To develop an ICT platform for creating an environment that integrates information and coordinates activities.
Promote scaling-up of good practices in integrated care and telemonitoring, and transfer learning and knowledge on implementation, development and consolidation of good practices.
Help reducing the burden of chronic diseases while ensuring the sustainability and response to the capacity of healthcare systems, promoting the implementation of policies and translational initiatives.
Latest News
The C3-Cloud project holds its 5th plenary meeting in Bonn
The 5th plenary session of the C3-Cloud Project took place [...]
The European project UPRIGHT intervention kicks off in the Basque Country
The "Universal Preventive Resilience Intervention Globally implemented in schools to [...]
Conference on collaborative approach to Multimorbid Patients in Osakidetza
On 9 October the conference "Collaborative Approach to Multimorbid Patients [...]
6th Conference of the Health Services in Chronic Disease Research Network (REDISSEC)
On 25 October 2018 the 6th Conference of the Health [...]
The aims of the Association are:
- Through research in health services, scientifically substantiate the programs and policies of the health system in the aforementioned areas.
- Disseminate and apply research results, preferentially enhancing applied research and its transfer to clinical practice and health management, as well as, where appropriate, public health programs and to social innovation.
- Promote and develop research in health and socio-health services using existing capacities in Osakidetza – Basque Public Health Service, and facilitating the connection with other agents and sectors involved in the areas of elderly age, chronicity and dependence.
- Emphasis on applied and translational research, oriented towards the generation of economic and social value.
- Collaborate with other agents to contribute to the generation of social and economic value in the Basque Country.
- Contribute to positioning the health system and the Basque Country as an international reference in the areas subject of dedication of the Association.
The Kronikgune Association is a non-profit association constituted in accordance with Organic Law 1/2002 of 22 March, which regulates the right of association, and Law 7/2007, of 22 June, concerning associations in the Basque Country.
On 07 July 2011, the Kronikgune Association was registered in the General Associations Registry of the Basque Country with number AS/B/16142/2011.
The Kronikgune Association is run from the Directorate for Healthcare Research and Innovation of the Basque Country regional government's Department of Health, as established in Decree 80/2017 of 11 April, which establishes the organic and operational structure of the Department of Health.
Specialist Areas
The health, social and economic consequences of chronicity.
Models for identifying chronic patients, especially the more complex cases.
The design and interventional of personalized (patient-centred) interventions.
Integrated care systems.
e-Health and the use of technology in this field.

subset: commoncrawl


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Dec 21, 2015. It's literally not Christmas if I don't hear this song at least once (or 17 times). Not sure you can get any Blacker than a funk-singing Black man.
" Wow Christmas Red" is a combination of well known, traditional Christmas songs and carols, along with newly composed Contemporary Christian Music Christmas songs. " Wow Christmas Red" is one of the very best various artists, Christmas compilation albums recorded in Contemporary Christian Music.
Oct 28, 2011В В· Black gospel christmas music. Children christmas songs. Christian christmas music. List Rules Vote up all of your favorite Christmas-themed gospel songs and add any.
Vote up the greatest Christian Christmas songs if it isn't already on the list. Find album reviews, stream songs, credits and award information for WOW Gospel Christmas - Various Artists on AllMusic - 2013 - EMI Gospel's two-disc Wow. Christmas Songs - Christian Artists Spotify. Christmas Album by: Josh Wilson Spotify URL: Play in Spotify. Do you have any tips on Christian artists on Spotify? Find black gospel tracks, artists, and albums. Find the latest in black gospel music at Last.
fm. christian; The tag or term. In this post related to Christian sheet music, we highlight fifty contemporary Christian Christmas songs. These songs were performed and/or written by some of your favorite contemporary Christian music artists including Amy Grant, NewSong, Steven Curtis Chapman, Michael W.
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Here are the top 100 Christmas worship songs sold at PraiseCharts since September, 2011. Newly Added Artists; Albums; Artists. Top 100 Christian Song Charts.
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Home Tags Telford & Wrekin Council
Tag: Telford & Wrekin Council
Telford's Got Talent final this weekend
The Telford's Got Talent finals take place this weekend with thirteen acts battling it out this weekend to be crowned Telford's Got Talent Winner 2019.
Shropshire Council leader says there's no intention of amalgamating with Telford & Wrekin Council
The leader of Shropshire Council has today issued a statement saying the Council has absolutely no intention of seeking any amalgamation with Telford & Wrekin Council.
Nuplace announces pre-tax profits
Rental housing provider Nuplace owned by Telford & Wrekin Council has announced pre-tax and pre-final audit operating profits of £500,000.
Telford & Wrekin Council formally refers hospital shake-up plans to Health Secretary
Telford & Wrekin Council has formally referred the Future Fit decision to the Secretary of State for Health and Social Care.
Council sets up £500k fund for Lawley and Lightmoor
Telford & Wrekin Council has set aside a half a million pound fund for Lawley and Lightmoor.
Telford Ice Rink to benefit from improvements
Telford Ice Rink is to benefit from a £75,000 investment from Telford & Wrekin Council for improvements.
New Lilleshall Hill nature reserve set to be designated
Lilleshall Hill is set to become the next to be officially adopted local nature reserve in Telford and Wrekin bringing the total number to 16.
Telford & Wrekin Council approves budget for the next year
Telford & Wrekin Council has approved its budget for the next year that will see almost an extra £6 million invested into adult social care and children's services.
£12m to be invested improving Telford streets and highways
Telford & Wrekin Council is to invest £12m in another 222 improvement schemes across the borough.
Telford's Got Talent returns for second year
Telford's Got Talent is to return for a second year following last year's event which marked Telford's 50th birthday and 50 years of Oakengates Theatre @ The Place.
New 210 pupil primary school planned for Telford
A new 210 pupil primary school is set to be built in Telford adjacent to Junction 4 of the M54.
Telford Child Sexual Exploitation Inquiry set to recruit independent chair
The Commissioning Body for Telford and Wrekin's inquiry into Child Sexual Exploitation is set to start recruiting an independent chair.


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text: Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs SyndromeGarcía-Martín, Elena, MD, PhD; Jiménez-Jiménez, Félix Javier, MD, PhD; Alonso-Navarro, Hortensia, MD, PhD; Martínez, Carmen, MD, PhD; Zurdo, Martín, MD; Turpín-Fenoll, Laura, MD, PhD; Millán-Pascual, Jorge, MD; Adeva-Bartolomé, Teresa, MD, PhD; Cubo, Esther, MD, PhD; Navacerrada, Francisco, MD; Rojo-Sebastián, Ana, MD; Rubio, Lluisa, MD; Ortega-Cubero, Sara, MD; Pastor, Pau, MD, PhD; Calleja, Marisol, CN; Plaza-Nieto, José Francisco, MD; Pilo-de-la-Fuente, Belén, MD, PhD; Arroyo-Solera, Margarita, MD; García-Albea, Esteban, MD, PhD; Agúndez, José A.G., MD, PhDSection Editor(s): Maohua, Xie. Medicine: August 2015 - Volume 94 - Issue 34 - p e1448 doi: 10.1097/MD.0000000000001448 Research Article: Observational Study Open Abstract Author InformationAuthors Article OutlineOutline Article MetricsMetrics Several neurochemical, neuropathological, neuroimaging, and experimental data, suggest that iron deficiency plays an important role in the pathophysiology of restless legs syndrome (RLS). Heme-oxygenases (HMOX) are an important defensive mechanism against oxidative stress, mainly through the degradation of heme to biliverdin, free iron, and carbon monoxide. We analyzed whether HMOX1 and HMOX2 genes are related with the risk to develop RLS. We analyzed the distribution of genotypes and allelic frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 SNPs, as well as the presence of Copy number variations (CNVs) of these genes in 205 subjects RLS and 445 healthy controls. The frequencies of rs2071746TT genotype and rs2071746T allelic variant were significantly lower in RLS patients than that in controls, although the other 3 studied SNPs did not differ between RLS patients and controls. None of the studied polymorphisms influenced the disease onset, severity of RLS, family history of RLS, serum ferritin levels, or response to dopaminergic agonist, clonazepam or GABAergic drugs. The present study suggests a weak association between HMOX1 rs2071746 polymorphism and the risk to develop RLS in the Spanish population. From the Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain (EG-M, JAGA); Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey (Madrid), Spain (FJJ-J, HA-N, FN, MC, JFPN, BP-D-LF, MA-S); Department of Medicine-Neurology, Hospital "Príncipe de Asturias". Universidad de Alcalá, Alcalá de Henares (Madrid), Spain (FJJ-J, HA-N, AR-S, LR, EG-A); Department of Pharmacology, University of Extremadura, Badajoz, Spain (CM); Section of Neurology, Hospital Virgen del Puerto, Plasencia (Cáceres), Spain (MZ); Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan (Ciudad Real), Spain (LT-F, JM-P); Unit of Neurology, Clínica Recoletas, Zamora, Spain (TA-B); Section of Neurology, Hospital Universitario de Burgos, Burgos, Spain (EC); CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain (SO-C, PP); Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain (SO-C, PP); Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain (PP); and Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain (PP). Correspondence: Félix Javier Jiménez-Jiménez, C/Marroquina 14, 3 B, E-28030 Madrid (e-mail: firstname.lastname@example.com;email@example.com). Abbreviations: CNVs = copy number variations, DNA = deoxyribonucleic acid, ET = Essential tremor, GABA = gamma-hydroxybutyric acid, HMOX = Heme-oxygenase, HO = Heme-oxygenase, HSP = Heat Shock Protein, IRLSSGRS = International Restless Legs Syndrome Study Group Rating Scale, PD = Parkinson's disease, qPCR = Real-time quantitative polymerase chain reaction, RLS = Restless legs syndrome, RNA = Ribonucleic acid, RR = Relative risk, SNP = single nucleotide polymorphism, VNTR = Variable number tandem repeats, WED = Willis Ekbom Disease. Sources of Funding: This work was supported in part by Grants PI12/00241, PI12/00324 and RETICS RD12/0013/0002 from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Madrid, Spain, and GR10068 from Junta de Extremadura, Mérida, Spain, and PRIS10016 (Fundesalud, Mérida, Spain), and by grants from the Spanish Ministry of Science and Innovation SAF2006-10126 (2006–2009) and SAF2010–22329-C02–01 (2011–2013) to P.P and by the "Unión Técnica de Empresas" (UTE) project FIMA to P.P. and project from the Centro de Investigaciones Médicas Aplicadas (CIMA), Spain. Partially funded with FEDER funds. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no conflicts of interest to disclose. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 Received June 10, 2015 Received in revised form July 24, 2015 Accepted July 30, 2015 Abstract INTRODUCTION PATIENTS AND METHODS Patients and Controls Ethical Aspects Genotyping Statistical Analysis RESULTS DISCUSSION REFERENCES Back to Top | Article Outline INTRODUCTION Despite there are many data supporting the role of genetic factors in the aetiology and the pathogenesis of restless legs syndrome (RLS), also called Willis–Ekbom disease (WED), such as the high frequency of family history of RLS reported by patients with this syndrome, data found in family studies, and the higher concordance rates in monozygotic twins when compared with dizygotic ones, the identification of the responsible gene(s) remains to be clarified (revised in reference).1 The pathophysiology of idiopathic RLS is not well established. Although recent reports suggest the possible role of several neurotransmitters and/or neuromodulators such as aspartate, gamma-hydroxybutyric acid (GABA), glutamate and opiates, and a possible relation with vitamin D deficiency, the main hypotheses (likely interconnected) are dopaminergic dysfunction and iron deficiency (revised in reference).2 Heme oxygenase is an essential enzyme in heme catabolism, and it occurs as 2 main isozymes, an inducible heme oxygenase-1 (HMOX1) and a constitutive heme oxygenase-2 (HMOX2), which are encoded by the genes designated, respectively, as HMOX1, HO-1 or HSP32 (gene identity 3162, chromosome 22q13.1) and HMOX2 or HO-2 (gene identity 3163, chromosome 16p13.3). Several recent studies have shown association between certain single nucleotide polymorphisms (SNPs) in the HMOX13–6 and HMOX25,7 genes and the risk for Parkinson's disease (PD)3–5,7 and for essential tremor (ET).6 Because of the important role of brain iron deficiency in RLS, suggested by neuropathological, transcranial sonography, neuroimaging, and experimental data, it seems reasonable to study the possible association between SNPs related with iron metabolism and the risk for RLS. With the aim to investigate a possible association between HMOX1 and HMOX2 polymorphisms and the risk of developing RLS, we genotyped HMOX1 and HMOX2 SNPs in a large group of Caucasian Spanish RLS patients and controls. Back to Top | Article Outline PATIENTS AND METHODS Patients and Controls We studied 205 unrelated patients diagnosed with idiopathic RLS according to established RLS diagnostic criteria,8,9 and 445 gender-matched controls. Demographic data of both series are summarized in Table 1. Recruitment and diagnosis of RLS patients was carried out by consultant neurologists with expertise in Movement Disorders belonging to the Movement Disorders Units of 5 Hospitals. Inclusion criteria, besides the diagnosis of idiopathic RLS, were the absence of other previous neurological diseases, and the exclusion of possible causes of secondary RLS such as anaemia, renal failure, rheumatoid arthritis, peripheral neuropathy, and exposure to neuroleptics, antidepressants, or other drugs able to induce or to aggravate RLS. For this purpose, all patients underwent laboratory studies (blood count, routine biochemistry, iron metabolism studies, serum levels of vitamin B12, folic acid, and thyroid hormones, proteinogram, antinuclear antibodies, rheumatoid factor, and nerve conduction studies). The International RLS Study Group Rating Scale (IRLSSGRS)10 was used to assess RLS severity. TABLE 1 Positive family history of RLS was reported by 115 patients, 46 had ferritin levels between 30 and 50 ng/ml and 157 >50 ng/ml. Regarding previous treatments 159 have received dopamine agonists, 59 clonazepam, and 34 gabapentin or pregabaline, either alone or in combination. The 445 controls were healthy Caucasian Spanish individuals matched by gender (275 of then were recruited from the Clínica Universitaria de Navarra, Pamplona, Spain; and the remaining 270 were recruited at the Infanta Cristina University Hospital, Badajoz, Spain). None of the controls had RLS, tremor, or other movement disorders. Back to Top | Article Outline Ethical Aspects All the participants included in the study gave their written informed consent after full explanation of the procedure. The Ethics Committees of Clinical Investigation of the Province of Cáceres (Cáceres, Spain), University Hospital "Príncipe de Asturias" (University of Alcalá, Alcalá de Henares, Madrid, Spain), the Infanta Cristina University Hospital (Badajoz, Spain), and Clínica Universitaria de Navarra (Pamplona, Spain) approved the study that was conducted according to the principles enumerated in the Helsinki Declaration of 1975. Most of the patients recruited had participated in other previous studies of genetic association with RLS risk.11–14 Back to Top | Article Outline Genotyping Two single nucleotide polymorphisms in the HMOX1 gene and two polymorphisms in the HMOX2 gene were studied by means of TaqMan probes. Analyses included the HMOX1 SNP rs2071746 (an upstream variant), HMOX1 rs2071747 (a missense mutation within the exon 1 of the HMOX1 gene), the SNP rs2270363 (a polymorphism in the regulatory region of the human HMOX2 gene), and rs1051308 (a polymorphism in the 3′untranslated region). The selection of these SNPs was done because of their putative functional effects and their expected allele frequency in Caucasian individuals.5,7 Genotyping performed in genomic DNA from venous blood samples of participants and was carried out using TaqMan assays (Applied Biosciences Hispania, Alcobendas, Madrid, Spain) designed to detect the four previously mentioned SNPs designated respectively by the supplier with the following part numbers: C__15869717_10, C__22272778_10, C__15957370_10 and C___9695078_1_. An Eppendorf realplex thermocycler, using fluorescent probes, was used for the detection by qPCR. The amplification conditions were the following: after a denaturation time of 10 min at 96 °C, 45 cycles of 92 °C 15 s and 60 °C 90 s were carried out and fluorescence was measured at the end of each cycle and at endpoint. Determinations were done by triplicate in all samples, and then genotypes were assigned both using a gene identification software (RealPlex 2.0, Eppendorf) and analysing the reference cycle number for each fluorescence curve, calculated by means of the CalQPlex algorithm (Eppendorf). The TaqMan copy number assays Hs00774483_cn and Hs01223070_cn, respectively, were used for the analysis of copy number variations (CNVs) of the HMOX1 and HMOX2 genes. Both assays were designed to hybridize within the open reading frame in the target genes (Applied Biosciences Hispania, Alcobendas, Madrid, Spain). An Applied Biosystems 7500 real-time thermocycler using as a copy number reference assay RNAse P was used to carry out the amplification, as described by the manufacturer. All reactions were carried out in quadruplicate. The analysis of the results were performed using the CopyCaller Software (Applied Biosciences Hispania). According to standard procedures in CNV analyses, we designed as heterozygous (null/present) those samples with a single copy of the corresponding gene. As the probes were designed to detect exonic sequences, even if the rest of the gene would remain in these so-called null alleles, the translated protein would not be functional. Back to Top | Article Outline Statistical Analysis The DeFinetti program (http://ihg.gsf.de/cgi-bin/hw/hwa1.pl) was used to analyze the Hardy–Weinberg equilibrium, the PLINK software15 to perform the allelic and genotype analyses, and the program PHASE v2.1.116 to perform haplotype reconstruction using the default model for recombination rate variation with 1000 iterations, 500 burn-in iterations, and a thinning interval of 1 was used. Diplotypes were obtained from the combination of haplotypes in the best run (the one that showed the maximum consistency of results across all runs.17 Statistical analyses were performed using the SPSS 19.0 for Windows (SPSS Inc, Chicago, IL). We calculated intergroup comparison values by means of the χ2 or Fisher tests when appropriate, and calculated the 95% confidence intervals as well. The False discovery rate procedure18 was used to calculate correction for multiple testing (Pc values). The determination of the sample size was done from variant allele frequencies observed in control individuals with a genetic model analyzing the frequency for carriers of the disease gene with a RR value = 1.5 (P = 0.05). The statistical power for 2-tailed associations for the presence of the SNPs identified in this study (rs2071746, rs2071747, rs2270363 and rs1051308) was 95.06%, 38.51%, 92.72% and 94.23%, respectively. The Breslow–Day test was used to analyze testing for heterogeneous association (homogeneity test). The negative predictive value (NPV) was calculated as d/r2 (d = number of control individuals with the risk factor absent; r2 = sum of patients and controls with the risk factor absent).19 Back to Top | Article Outline RESULTS The frequencies of the rs2071746, rs2071747, rs2270363, and rs1051308 genotypes and allelic variants were in Hardy–Weinberg's equilibrium, both in RLS patient and control groups (Table 2). None of the patients and only 2 control individuals carried a single copy of the HMOX1 and HMOX2 genes, and hence CNVs were not further considered as major putative risk factors. The frequencies of rs2071746TT genotype and rs2021746T allele were significantly lower in RLS patients than in controls, both in the whole series (Table 2) and in female gender (Table 3). These differences remained significant for the rs2071746 allele frequency after multiple comparison analysis according to the false discovery rate correction. The frequencies of rs2071747, rs2270363, and rs1051308 did not differ significantly between RLS patient and control groups. TABLE 2 TABLE 3 Mean + SD age at the onset of RLS did not differ between RLS patients carrying the genotypes rs2071746AA, rs2071746AT, and rs2071746TT (44.4 ± 16.6, 43.2 ± 17.9, and 44.4 ± 16.6 years, respectively); genotypes rs2071747GG and rs2071747GC (43.6 ± 17.0 and 43.8 ± 15.4 years, respectively); genotypes rs2270363GG, rs2270363GA, and rs2270363AA (43.4 ± 17.6, 44.2 ± 16.8, and 42.3 ± 13.1 years, respectively); and genotypes rs1051308AA, rs1051308AG, and rs1051308AA (42.9 ± 17.3, 45.0 ± 17.1, and 41.6 ± 14.5 years, respectively). Mean + SD IRLSSGRS scores were similar for RLS patients carrying genotypes rs2071746AA, rs2071746AT, and rs2071746TT (24.6 ± 7.0, 25.02 ± 6.0, and 23.3 ± 8.0, respectively); genotypes rs2071747GG and rs2071747GC (24.8 ± 6.5 and 21.7 ± 6.4, respectively); genotypes rs2270363GG, rs2270363GA, and rs2270363AA (24.6 ± 6.8, 24.7 ± 6.6, and 22.7 ± 6.9, respectively); and genotypes rs1051308AA, rs1051308AG, and rs1051308AA (24.8 ± 6.7, 23.8 ± 6.6, and 23.8 ± 6.8, respectively). The distribution of genotypes and allelic frequencies was similar in RLS patients with positive family history of RLS than in those with negative family history of RLS (Table 4), RLS patients with relatively low serum levels of ferritin (30–50 ng/ml) versus those with serum ferritin levels > 50 ng/ml (Table 4), and those RLS patients in which RLS symptoms improved with dopamine agonists, clonazepam, or gabapentin/pregabaline therapy compared with those who did not improve with these drugs (Table 5). TABLE 4 TABLE 5 Back to Top | Article Outline DISCUSSION Family reports of RLS are usually consistent with an autosomal dominant pattern of inheritance, although families with recessive or non-mendelian patterns have been described as well. To date, linkage studies have identified at least 8 genes/loci (most of them apparently autosomal dominant) in families with RLS. Association between several variants of MEIS1 (closely related with iron metabolism),20PTPRD, and BTBD9 genes and with the risk of developing RLS has been found in genome wide association studies (GWAS),1 whereas PCDHA3 gene has been found to be related with the development of RLS in a large German family by using exome sequencing studies.1 Case-control association studies in RLS are scarce and inconclusive (revised in).1 Data from the present case-control association study suggest a weak association between the allelic variant HMOX1 rs2071746T, but not of the other 3 studied SNPs in the HMOX, and the risk for RLS. However, none of the studied SNPs were related with the age at onset or severity of RLS, positivity of family history or RLS, serum ferritin levels, and response to several treatments. The lack of relation between SNPs in the HMOX gene and serum ferritin levels is on the line of a previous study by Oexle et al,21 that described that SNPs at the known RLS loci and iron-related genes did not significantly affect serum iron parameters in several cohorts. We have previously reported association between HMOX1 rs2071746T variant and the risk for PD and ET,5,6 suggesting a possible link between these diseases. However, how this SNP might change HMOX transcription both in PD (associated with elevated iron content) and RLS (associated with iron deficiency), and the possible putative mechanisms suggesting an association between HMOX and RLS could be speculative. So far there are no clues on putative biological mechanisms underlying the association found. The rs2071746 SNP is located in the 5′ area, ∼500 bp before the coding area, and therefore the most likely mechanism would be related to gene expression. The area where the SNP is located has several transcription factor binding sites. One of these, designated as CUTL1 [T00100] is present in the wild-type sequence, but disappears in the mutated sequence. The disruption of this transcription factor-binding site may underlie differences in gene expression. In the brain, the HMOX pathway is a very important defensive mechanism against oxidative stress, mainly through the degradation of heme to biliverdin, free iron, and carbon monoxide. Moreover, an up-regulation of HMOX1 expression (resulting in increase of oxidative stress and sequestration of iron non-linked to transferrin in the mitochondrial department) has been found in the brains of patients with PD, Alzheimer's disease, and multiple sclerosis.22,23 Despite the pathophysiology of RLS is not well-established, it has been suggested an important role of iron deficiency in the pathogenesis of idiopathic RLS.1 Most of the magnetic resonance imaging studies found decreased iron content,24–28 and transcranial ultrasonography studies hypoechogenicity (reflecting decreased iron as well),29–31 in the substantia nigra of RLS patients compared with controls. Moreover, neuropathological studies have found decreased concentrations of iron, ferritin, and other proteins related with iron homeostasis in the substantia nigra of RLS patients.32–36 The results of studies assessing cerebrospinal fluid and serum/plasma levels of iron, ferritin, and transferrin are controversial (revised in).2 Several data in experimental models resembling RLS suggest an important interaction between iron deficiency and the dopaminergic system in the pathogenesis of RLS (revised in).2 To our knowledge, HMOX1 and HMOX2 expression has not been measured in neuropathological studies of RLS patients yet. It could be proposed that if the iron content is decreased in the substantia nigra of RLS patients, HMOX should act as protective against iron-related oxidative stress, and alterations in HMOX1 and HMOX2 genes could be related with the iron deficiency model of the pathogenesis of RLS. A limitation of the present study is that, whereas 3 SNPs had a high statistical power, the other one, designated as rs2071747, had not. However, rs2071747 is an allele with a very low minor frequency (MAF) in healthy Europeans (0.045 in this study and 0.060 in the 1000 genomes database). Such SNP is also very rare in other human populations, MAF ranging from 0.020 to 0.050 (http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db = core;r = 22:35776685–35777685;v = rs2071747;vdb = variation;vf = 1641286). To obtain a reliable statistical power for such SNP with the RR value = 1.5 (P = 0.05), the minimum sample size is estimated to be 1900 case-control pairs. However, it should be stressed that the significant findings in this study are related to another SNP that has a high statistical power: rs2071746 has a power equal to 95.6%. Another potential limitation should be a selection bias. Although it is well known that in epidemiological studies the male-to-female ratios of incidence rate of RLS are in the range of 1:1.5 to 1:2.0 in adult populations, the male-to-female ratio of RLS patients is ∼1:5. This proportion is likely to be related with the fact that the recruitment of patients was done in a clinical (hospital-based) setting. Although the results of the present study should be taken with caution because of the previously discussed limitations, and deserve further replication studies in other populations, they suggest a slightly decreased risk for RLS in Spanish Caucasian individuals carrying the HMOX1 rs2021746T allele variant.Back to Top | Article Outline REFERENCES 1. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Latest perspectives in genetic risk factors for restless legs syndrome. Eur Neurol Rev 2013; 8:90–96.http://http://www.touchneurology.com/articles/latest-perspectives-genetic-risk-factors-restless-legs-syndrome. Cited Here... 2. Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG. Neurochemistry of idiopathic restless legs syndrome. Eur Neurol Rev 2015; 10:35–44.http://http://www.touchneurology.com/articles/neurochemistry-idiopathic-restless-legs-syndrome. Cited Here... 3. Infante J, García-Gorostiaga I, Sánchez-Juan P, et al. Synergistic effect of two oxidative stress-related genes (heme oxygenase-1 and GSK3β) on the risk of Parkinson's disease. Eur J Neurol 2010; 17:760–762. Cited Here... | View Full Text | PubMed | CrossRef 4. Infante J, Sierra M, Sánchez-Juan P, et al. Interaction between heme oxygenase-1 genotypes and exposure to pesticides in Parkinson's disease. Mov Disord 2011; 26:916–917. Cited Here... | View Full Text | PubMed | CrossRef 5. Ayuso P, Martínez C, Pastor P, et al. An association study between Heme oxygenase-1 genetic variants and Parkinson[Combining Acute Accent]s disease. Front Cell Neurosci 2014; 9:298. Cited Here... | PubMed 6. Ayuso P, Agúndez JAG, Alonso-Navarro H, et al. Heme oxygenase-1 and 2 common genetic variants and risk for essential tremor. Medicine (Baltimore) 2015; 94:e968. Cited Here... | View Full Text | PubMed | CrossRef 7. Ayuso P, Martínez C, Lorenzo-Betancor O, et al. A polymorphism located at an ATG transcription start site of the heme oxygenase-2 gene is associated with classical Parkinson's disease. Pharmacogenet Genomics 2011; 21:565–571. Cited Here... | View Full Text | PubMed | CrossRef 8. Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology work shop at the National Institute of Health. Sleep Med 2003; 4:101–119. Cited Here... | PubMed | CrossRef 9. Allen RP, Picchietti DL, Garcia-Borreguero D, et al. International Restless Legs Syndrome Study Group 2014. Restless legs syndrome/Willis–Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria—history, rationale, description, and significance. Sleep Med 2014; 15:860–873. Cited Here... | PubMed 10. Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs yndrome. Sleep Med 2003; 4:121–132. Cited Here... | PubMed | CrossRef 11. Roco A, Jiménez-Jiménez FJ, Alonso-Navarro H, et al. MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome. J Neural Transm 2013; 120:463–467. Cited Here... | PubMed | CrossRef 12. Jiménez-Jiménez FJ, Alonso-Navarro H, Martínez C, et al. Dopamine Receptor D3 (DRD3) gene rs6280 variant and risk for restless legs syndrome. Sleep Med 2013; 14:382–384. Cited Here... | PubMed | CrossRef 13. Jiménez-Jiménez FJ, Alonso-Navarro H, Martínez C, et al. The solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, rs3794087 variant and assessment risk for restless legs syndrome. Sleep Med 2014; 15:266–268. Cited Here... | PubMed | CrossRef 14. Jiménez-Jiménez FJ, Alonso-Navarro H, Martínez C, et al. Neuronal nitric oxide synthase (nNOS NOS1) rs693534 and rs7977109 variants and risk for restless legs syndrome. J Neural Transm 2015; 122:819–823. Cited Here... | PubMed | CrossRef 15. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81:559–575. Cited Here... | PubMed | CrossRef 16. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978–989. Cited Here... | PubMed | CrossRef 17. Agúndez JA, Golka K, Martínez C, et al. Unraveling ambiguous NAT2 genotyping data. Clin Chem 2008; 54:1390–1394. Cited Here... | PubMed | CrossRef 18. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Statist Soc Ser B 1995; 57:289–300. Cited Here... 19. Altman DG, Bland JM. Diagnostic tests 2: predictive values. BMJ 1994; 309:102. Cited Here... | View Full Text | PubMed | CrossRef 20. Catoire H, Dion PA, Xiong L, et al. Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis. Ann Neurol 2011; 70:170–175. Cited Here... | View Full Text | PubMed | CrossRef 21. Oexle K, Schormair B, Ried JS, et al. Dilution of candidates: the case of iron-related genes in restless legs syndrome. Eur J Hum Genet 2013; 21:410–414. Cited Here... | PubMed | CrossRef 22. Poon HF, Calabrese V, Scapagnini G, et al. Free radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress. J Gerontol A Biol Sci Med Sci 2004; 59:478–493. Cited Here... | PubMed 23. Schipper HM. Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress. Ann N Y Acad Sci 2004; 1012:84–93. Cited Here... | View Full Text | PubMed | CrossRef 24. Allen RP, Barker PB, Wehrl F, et al. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 2001; 56:263–265. Cited Here... | View Full Text | PubMed | CrossRef 25. Earley CJ, Barker B, Horská P, et al. RP. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med 2006; 7:458–461. Cited Here... | PubMed | CrossRef 26. Moon HJ, Chang Y, Lee YS, et al. T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early- and late-onset restless legs syndrome. J Clin Neurol 2014; 10:197–202. Cited Here... | PubMed 27. Godau J, Klose U, Di Santo A, et al. Multiregional brain iron deficiency in restless legs syndrome. Mov Disord 2008; 23:1184–1187. Cited Here... | View Full Text | PubMed | CrossRef 28. Rizzo G, Manners D, Testa C, et al. Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging. Mov Disord 2013; 28:1886–1890. Cited Here... | View Full Text | PubMed | CrossRef 29. Ryu JH, Lee MS, Baik JS. Sonographic abnormalities in idiopathic restless legs syndrome (RLS) and RLS in Parkinson's disease. Parkinsonism Relat Disord 2011; 17:201–203. Cited Here... | PubMed | CrossRef 30. Godau J, Manz A, Wevers AK, et al. Sonographic substantia nigra hypoechogenicity in polyneuropathy and restless legs syndrome. Mov Disord 2009; 24:133–137. Cited Here... | View Full Text | PubMed | CrossRef 31. Godau J, Wevers AK, Gaenslen A, et al. Sonographic abnormalities of brainstem structures in restless legs syndrome. Sleep Med 2008; 9:782–789. Cited Here... | PubMed | CrossRef 32. Connor JR, Boyer PJ, Menzies SL, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 2003; 61:304–309. Cited Here... | View Full Text | PubMed | CrossRef 33. Connor JR, Wang XS, Patton SM, et al. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology 2004; 62:1563–1567. Cited Here... | View Full Text | PubMed | CrossRef 34. Wang X, Wiesinger J, Beard J, et al. Thy1 expression in the brain is affected by iron and is decreased in restless legs syndrome. J Neurol Sci 2004; 220:59–66. Cited Here... | PubMed | CrossRef 35. Snyder AM, Wang X, Patton SM, et al. Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol 2009; 68:1193–1199. Cited Here... | View Full Text | PubMed | CrossRef 36. Connor JR, Ponnuru P, Wang XS, et al. Profile of altered brain iron acquisition in restless legs syndrome. Brain 2011; 134:959–968. Cited Here... | View Full Text | PubMed | CrossRef Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Article Outline Abstract INTRODUCTION PATIENTS AND METHODS Patients and Controls Ethical Aspects Genotyping Statistical Analysis RESULTS DISCUSSION REFERENCES Source Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome Medicine94(34):e1448, August 2015. Full-Size Email + Favorites Export View in Gallery Email to a Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at Medicine. Send a copy to your email Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time. Email to a Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at Medicine. 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Scene of the CrimeNovember 29, 1970
Tatort is a long-running German/Austrian/Swiss, crime television series set in various parts of these countries. The show is broadcast on the channels of ARD in Germany, ORF 2 in Austria and SF1 in Switzerland. The first episode was broadcast on November 29, 1970. The opening sequence for the series has remained the same throughout the decades, which remains highly unusual for any such long-running TV series up to date.
Each of the regional TV channels which together form ARD, plus ORF and SF, produces its own episodes, starring its own police inspector, some of which, like the discontinued Schimanski, have become cultural icons.
The show appears on DasErste and ORF 2 on Sundays at 8:15 p.m. and currently about 30 episodes are made per year. As of March 2013, 865 episodes in total have been produced.
Tatort is currently being broadcast in the United States on the MHz Worldview channel under the name Scene of the Crime.
Polizeiruf 110June 27, 1971
Polizeiruf 110 is a long-running German language detective television series. The first episode was broadcast 27 June 1971 in the German Democratic Republic, and after the dissolution of Fernsehen der DDR the series was picked up by ARD. It was originally created as a counterpart to the West German series Tatort, and quickly became a public favorite.
In contrast with other television crime series, in which killings are practically the primary focus, while Tatort handled homicide cases, the cases handled in the GDR TV's Polizeiruf were more often the more frequent, and less serious, crimes such as domestic violence, extortion, fraud, theft and juvenile delinquency, as well as alcoholism, child abuse and rape. Contrary to Tatort, which concentrated on the primary characters and their private lives, police procedure was the center of attention of Polizeiruf, especially in the earlier episodes. The scriptwriters attached particular importance to representation of the criminal and his state of mind, as well as the context of the crime. Many episodes aimed to teach and enlighten the audience about what does and what doesn't constitute appropriate behaviour and appropriate thought, rather than just to entertain. Polizeiruf was one of the few broadcasts by GDR media in which the real problems and difficulties of the supposedly more advanced socialist society could be displayed and discussed to some extent, albeit in a fictionalized and pedagogicalized environment.
Hubert & StallerNovember 2, 2011
A show about two Bavarian police officers, Franz Hubert and Johannes Staller, who sometimes work a bit differently. Where Franz wants to follow regulations, Johannes likes to do things his own way.
GroßstadtrevierDecember 16, 1986
Follow the everyday work of a fictional police station on the Kiez of Hamburg.
In aller FreundschaftOctober 26, 1998
German soap opera about the staff of the fictional hospital "Sachsenklinik" in the city of Leipzig.
Türkisch für AnfängerMarch 14, 2006
Türkisch für Anfänger is a critically acclaimed German television comedy-drama series, which premiered on March 14, 2006 on Das Erste. It was created by Bora Dağtekin and produced by Hoffmann & Voges Ent.
The show focuses on the German-Turkish stepfamily Schneider-Öztürk, their everyday lives and particularly on the eldest daughter Lena, who narrates the show. During the show's run of 52 episodes, topics covered included both typical problems of teenagers and cross-cultural experiences.
Due to popular demand, the crew shot a third season consisting of 16 episodes, which were aired in Fall 2008.
The show was also successful on foreign markets and got sold to and broadcast in more than 70 countries.
Meister Eder und sein PumucklSeptember 24, 1982
Pumuckl is a Kobold from a German radio play series for children. He is a descendant of the Klabautermänner. He is invisible to people around him except for the master carpenter Eder with whom Pumuckl lives.
Pumuckl was invented by Ellis Kaut for a radio play series of the Bavarian Radio in 1961. Later on it was turned into a very successful TV series. Three movies and a musical also deal with the adventures of the little kobold.
Pumuckl is one of the most popular characters in children's entertainment in Germany and several generations have now grown up with the cheeky but funny little Kobold.
In aller Freundschaft - Die jungen ÄrzteJanuary 22, 2015
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Auf AchseOctober 28, 1980
Auf Achse was a German television series on the ARD channel. The series ran from 1977 until 1996 and 86 episodes were produced altogether.
Donna LeonOctober 12, 2000
Donna Leon is a German television series based on the books of Donna Leon. It has been produced since 2000 by the ARD in Germany. This TV series is also shown in Spain and in Finland by Yle. Music: André Rieu.
Reiterhof WildensteinMay 10, 2019
We don't have an overview translated in English. Help us expand our database by adding one.
For Heaven's SakeJanuary 8, 2002
Sister Hanna is a spirited, witty, resolute, warm-hearted, and - attractive nun. With her wit and street cred, she takes charge of Kaltenthal Cloister, transforming it into a popular refuge for all those seeking help of one kind or another. She also brings new life to the sleepy provincial community, proving herself quite a match for her great rival and opponent, the mayor Wolfgang Wöller.
Der FahnderSeptember 21, 1984
Der Fahnder is a German television krimi series which was aired between 1984 and 2005.
In the Netherlands the series was broadcast by the VARA from 3 October 1985.
Bambi-VerleihungJanuary 1, 1948
We don't have an overview translated in English. Help us expand our database by adding one.
Die Sendung mit der MausMarch 7, 1971
Die Sendung mit der Maus is a highly acclaimed children's series on German television that has been called "the school of the nation". The show first aired on March 10, 1971. Originally called Lach- und Sachgeschichten für Fernsehanfänger, it was controversial because German law prohibited television for children under six years of age. The program was initially condemned by teachers and childcare professionals as bad for children's development, but is now hailed for its ability to convey information to children. The show has received over 75 awards. The first doctoral dissertation on the program was written in 1991. On March 7, 1999, the program's Internet site was launched and received 2,400 e-mails and 4 million hits on the first day.
Mord mit AussichtJanuary 7, 2008
Mord mit Aussicht is a German satirical crime comedy television series, produced by ARD, following the adventures of Sophie Haas, a detective from the city that takes a job in the fictional country village of Hengasch. Much of the humour of the series derives from the clichés of both city and provincial lives, in a similar manner to the English comedy crime series Midsomer Murders.
Sabine ChristiansenJanuary 4, 1998
We don't have an overview translated in English. Help us expand our database by adding one.
Servus BabyAugust 27, 2018
We don't have an overview translated in English. Help us expand our database by adding one.


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text:
Scotland win by 29 runs. The Canadians put in a great effort with the bat on day 3 but just didn't from enough solid partnerships. The Scots will be relieved as they were in the driving seat from day 1 and it would have been a horrible shock had the Canadians pulled off the run chase.
A good winning start to the ICC I'Cup for Scotland who now play Ireland in August while Canada play the Netherlands later this month in the 4-day format. Both teams will now be looking forward to the two ODI's next week on Tuesday and Wednesday.
Both matches will be held here at Mannofield in Aberdeen so if you can't join me there then we will have ball-by-ball coverage here on cricinfo.com with me Callum Stewart. For now it's goodbye from Scotland and have a good evening.
GEF Barnett b MacLeod 31 (79m 53b 6x4 0x6) SR: 58.49
END OF OVER:78 | (maiden) | CAN: 209/9
- Henry Osinde7 (10b)
- Geoff Barnett27 (50b)
- Gordon Drummond14-6-31-0


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LunaGracelynn: Feel bad for that devil he just gave away. Didn't seem like he wanted to leave ianTaming Master · C321
Wakka02: This writer has clearly read too much manga, because no commentator in their right mind would commentate in such a fashion...Godfather Of Champions · C6
Vizam: I request translators to use the term football if possible.Godfather Of Champions · C3
Williams1996: ugh i like this but if they keep calling it soccer its gonna annoy meGodfather Of Champions · C2
GamezNoob: Really ? Well , to each his own.
I rather have something unexpected then the exact same thing over and over in a different story.Godfather Of Champions · C1
I Love You, Monster: The Blindfolded Wife x The Masked Husband · C18
AnotherJunji: "is ugly" is super effective, Bbookbbook faints...Taming Master · C312
ayvarot: LB is so despicably scheming... Ian earn what he has using effort and they continuously "nerf" him pulling strings behind his back...Taming Master · C299
Hexendrach: "Can relatives come along?" She totally changed training expedition to school trip in her mind. SmhMy Master Disconnected Yet Again · C30
Jeanscout: Sword immortal (chef): i know I'm not worth being a called a chef just yet. But Master has placed ber trust in me so as a cook i will pesevere to be worthy of the title chef and one day be an immortal chef!
Lonemoon: (╯‵□′)╯︵┻━┻
Next you're gonna tell me your sword techniques is for cutting vegtables!?
Chef: 😨
Lonemoon: finally he realised how ritarded this is!
Chef: thank you supremacy! I cant believe all this time i failed to realise how to employ my skills better. Master with my sword techniques i shall make decorative vegetables!
SY: hmmm i rather have sashimi. *turns to Lonemoon* you may be terrible at cooking but your people management skills ain't bad.
Lonemoon: (╯‵□′)╯︵┻━┻
Chef: what's sashimi?My Master Disconnected Yet Again · C30
moongazer: Lol Lonemoon understanding of the world is being causally destroyed by Shen Ying 😂My Master Disconnected Yet Again · C27
dream_catcher07: A new policy: "Master is always right". 🤣 So funny..
On a serious note, if someone did a very terrible thing and the reason is 'it can't be helped', I'll certainly will do my own version of endless bashing.. 😤My Master Disconnected Yet Again · C27
Frankl: This ghost will be obedient.. This ghost will not disturb anyone nor this ghost will eat someone.. Just let this ghost stay in gafalon properly.. let this ghost become NEET... and.. never meet that monster woman again..My Master Disconnected Yet Again · C14
miqi: The reason are ******.
There is something called post traumatic disorder.My Master Disconnected Yet Again · C14
Dragon_Reader: Yi Qing - The rare sword Qi master, protector of innocents and justice, enemy of the Fiendish clan, the breath of fresh air in the world, the world ML....
Pig MC's personal cook....My Master Disconnected Yet Again · C13
Darkdelusion: Kuroko no cultivation - female versionMy Master Disconnected Yet Again · C13
drsh09: I usually mind my business but this is the second or third time I notice you doing this with other novels so please stop. It might be funny the first time you see it but it is bit too much when you keep seeing the same thing over and over again. These authors are nice enough to share their stories and creations with us readers and if you don't like their story I understand, to each it's own taste, however, you can always choice to not read their stories and leave it to us readers who enjoy these novels and you can always read what interest you. That why these authors would not get discouraged seeing these kind of comments just because, so please reframe from these kind of comments and if you would give a protective criticism I am sure the author would appreciate that instead.
I hope I did not not offend you, I just felt I should say something after seeing this comments few times 😅My Master Disconnected Yet Again · C13
Fleur207: And she said they'd make a carrot stew with the it. 😓My Master Disconnected Yet Again · C7
Bunnybell: Spoiler
he is though, boyfriend+exclusive chef, just his presence as boyfriend is same as MC's presence as wholeMy Master Disconnected Yet Again · C7
Thormented: Uhm... no one's going to comment on why a herbivorous rabbit took away the body of a cultivator?My Master Disconnected Yet Again · C7
Mochi233333: Cut her some slack😅 she was held back 2 times in primary school 😂😂😂My Master Disconnected Yet Again · C6
azmisaiha: Good time to ask that guy outside to cook for youMy Master Disconnected Yet Again · C6
Nimike: MY GOSH! SHUT THE F*** UP! IT WAS FUNNY THE FIRST TIME....BUT NOW! UGHHHHHH, You're just being plain RUDE!My Master Disconnected Yet Again · C6
Rectifier: I had imagined up what a ginseng might be up to a couple tens of roots. But never did I imagine it's carrot. Somehow feeling cheated .My Master Disconnected Yet Again · C4
Darkdelusion: Back off xianxia mc, the rabbit is innocent. He has fluffies waiting for him at his homeMy Master Disconnected Yet Again · C4
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Blessed to have been named as one of the five finalist for the NELA in the Education industry. The ceremony takes place on July 26th and I'll be sure to keep you posted. I really feel fortunate to even obtain a nod for the work I do in Student Affairs at Vanderbilt University.
Nashville Emerging Leader Awards
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Telematic Communication Box
Telematic Communication Box (TCB)
The Telematic Communication Box (TCB) is a control unit for telephone functions and telematics service. The control unit is one of the platforms for the functions of BMW ConnectedDrive. The focus of BMW ConnectedDrive is the intelligent networking of the driver with his vehicle and his surroundings.
The TCB control unit can establish a connection to the GSM and UMTS networks using a Net Access Device (NAD).
Functional description
The installation location of the Telematic Communication Box (TCB) is dependent on the series and production date! Observe installation location by means of the wiring diagram!
During the installation of a Headunit High (HU-H) a Telematic Communication Box (TCB) is also always installed. The Headunit High can convert telephone functions and telematics services via USB interface.
The BMW Professional telematics function comprises the following functions:
- Enhanced emergency call
- BMW Assist (information service)
- BMW Online
- BMW Mobile Office (e-mail and calendar)
- BMW AppCenter
- BMW Remote Access Service
- Manual BMW TeleServices call
- Automatic BMW TeleServices call
- BMW TeleServices diagnosis including BMW TeleServices help
- BMW TeleServices call* Integration in Check Control message
- BMW Teleservice Report
- BMW Teleservice Battery Guard
- BMW Teleservice Update
Also see functional description: BMW Professional telematics
|Cover of battery compartment
|Telematic Communication Box (TCB)
|26‐pin plug connection
|USB interface
|Emergency battery
|Connection for GSM aerial (for telematics services) and connection for emergency GSM aerial
Starting on 03/2013 there will be an additional connection for the GPS on the Telematic Communication Box (TCB).
Structure and inner electrical connection
The Telematic Communication Box (TCB) is connected to the vehicle electrical system by means of a 26-pin plug connection. In this, the bus connection is produced via the K-CAN2.
The TCB consists of 2 printed circuit boards. All interfaces to the vehicle and voltage supply and also CAN data line are located on the so-called main board. The 2nd printed circuit board is the Net Access Device. The connection to the aerials in the vehicle is thereby established. Both printed circuit boards are connected via 40-pin multi-pin connector.
The power distribution box in the junction box supplies the TCB control unit with terminal 30F.
|Telematic Communication Box (TCB)
Pin assignments
The graphic above shows only the supply and bus connection. The current pin assignment is recorded on the wiring diagrams in the ISTA diagnosis system (Integrated Service Technical Application). Click on the component code in the wiring diagram to activate the "Installation location" and "Pin assignment" tabs.
Nominal valuesObserve the following setpoint values for the Telematic Communication Box (TCB):
|Supply voltage
|9 to 16 V
|Temperature range
|-40 to 85 °C
Diagnosis instructions
Failure of the component
If communication to the Telematic Communication Box (TCB) fails, perform the standard checks (global testing procedure).


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"Hi Catharine, just wanted to give you an update on my last reading with you back in June. I'm always amazed at how accurate you are with descriptions of people coming into my life. In our session you mentioned there is a man with a shaved head and dark eyes will be helping me out with my career in 3D. Well a couple months later. I did my internship with an owner with that description. A week ago (a month after my internship was finished) he gave me a job offer! I will be making an appointment you again very soon for another reading 🙂
Well, here is where things might be a little more "out there" and magical. You see, we are all connected to a collective, universal wisdom and our inner wisdom. And when we read the Tarot cards—and connect with our intuition—we can tap into this universal wisdom. It's a little like connecting in with the collective mind, not just the individual mind.
Just as in any profession, mediums have specialties and areas of expertise. Unlike Allison Dubois in Medium, I don't work with the police in solving crimes. Or, unlike Melinda Gordon in The Ghost Whisperer, I don't help tormented souls cross over. Over the years, it has become very clear that my job lies in working with souls who have happily crossed over to the other side and, for the most part, are at peace. Sure, they may have regrets or unresolved issues, but they're not haunted or lost. Oftentimes, it's the living that are not at peace. The main goal of your deceased loved ones and spirit guides is to assist you in moving on, free of grief and struggle, so you can fulfill your life lessons and enjoy your time here on earth.
Just as in any profession, mediums have specialties and areas of expertise. Unlike Allison Dubois in Medium, I don't work with the police in solving crimes. Or, unlike Melinda Gordon in The Ghost Whisperer, I don't help tormented souls cross over. Over the years, it has become very clear that my job lies in working with souls who have happily crossed over to the other side and, for the most part, are at peace. Sure, they may have regrets or unresolved issues, but they're not haunted or lost. Oftentimes, it's the living that are not at peace. The main goal of your deceased loved ones and spirit guides is to assist you in moving on, free of grief and struggle, so you can fulfill your life lessons and enjoy your time here on earth.
The biblical basis is St. Paul's advice "Attend to reading" (1 Tim 4:13) which meant that Timothy his disciple should "apply to the reading of holy books, not in a passing way and for a short time, but regularly and for a considerable time," said St. Alphonsus Liguori, Doctor of the Catholic Church on Moral theology. St. Bernard of Clairvaux said that "spiritual reading and prayer are the arms by which hell is conquered and paradise won."
Mary-Anne is a professional Spiritual Medium, Published Author, Spiritual Educator, and TV Personality located just outside of Toronto, Ontario. Mary-Anne is one of Canada's top Spiritual Mediums who is highly sought after for her work in both mediumship readings and spiritual teaching. With compelling accuracy, she brings forward evidence - proof - that your loved ones still exist. Her connection and messages from heaven are rich with hea
Maryne Hachey is an Angel Therapist®, Psychic Medium, Author, Intuitive Healer, Mediator, Spiritual Teacher, Spiritual Guide and International Radio Show Host. Maryne Hachey communicates with your Angels and Guides to receive Divine guidance for all aspects of your life. She channels messages of love from God, the Angelic and Ascended Master realms, deceased loved ones and pets. Changing patterns in our life can be difficult, and sometimes ev
Mary-Anne is a professional Spiritual Medium, Published Author, Spiritual Educator, and TV Personality located just outside of Toronto, Ontario. Mary-Anne is one of Canada's top Spiritual Mediums who is highly sought after for her work in both mediumship readings and spiritual teaching. With compelling accuracy, she brings forward evidence - proof - that your loved ones still exist. Her connection and messages from heaven are rich with hea
Over 30 Yrs experience,TESTED and CERTIFIED, International Intuitive Psychic, Angel Reader, Life Coach, Spiritual Counselor, Empath & Reiki Master. Messages provided through SPIRIT GUIDE/ANGELIC MESSENGER contact. All messages come from a place of love and honesty, never fear or judgment based on sexuality or race. Sheri assists you with your life path, soul purpose, relationships, career, finances, manifesting your dreams, abundance and worki
Mina Crandon claimed to materialize a "spirit hand", but when examined by biologists the hand was discovered to be made from a piece of carved animal liver.[143] The German apport medium Heinrich Melzer was discovered to be a fraud in 1926. In a séance psychical researchers found that Melzer had small stones attached to the back of his ears by flesh coloured tape.[144] Psychical researchers who investigated the mediumship of Maria Silbert revealed that she used her feet and toes to move objects in the séance room.[145]
I met Ron almost a year and half ago. I got a reading with him in person, and he said things that helped me then (I don't remember specifics, but I remember feeling a little better). After that first reading, I didn't talk to Ron for a while ... it wasn't until ,maybe 10 months later that i reached out again. He lives a little further away from me than I would like, so I did a phone session with him the 2nd time around. After reconnecting with Ron, I have had several other phone sessions with him since last October, and I can say with 100% certainty that Ron is VERY honest, and goes the extra mile to ensure you understand what he's explaining. His phone sessions may even be better than his in person readings! He has multiple spreads/tools he utilizes to give you in depth knowledge of your situation, so you are better equipped to solve it! For me, Ron has always been very accurate and detailed with his analysis. He always gives a little extra , wheter it be with his time or advice, and that is so appreciated because it tells me he is present, and that's very important especially when getting services like this . I can always feel he is connecting with me because he is meant to do the work he is doing now. It shows in the way he presents the information to me and the effort he puts into it. It is very rare to find someone as detailed and accurate as Ron, and I am so grateful and thankful for his wisdom and honesty. Thank you, Ron!
My first reading was via phone call—the ad said the psychic was offering free mini-readings. She asked for my full name and birthday and Emily's. I gave her the details and almost instantly, she told me Emily wanted me to know that she's in a good place and that she's watching over the family. She also wanted me to be happy too, but my happiness only seems to last temporarily (note: aren't all emotions temporary though?).
It is easier than ever to connect with a love & relationship psychic guide, thanks to PsychicCenter's psychic readings. All you have to do is call 1-866-MY-ASTRO (1-866-692-7876) today, so we can connect you with one of the vetted relationship psychic readers in our exclusive community. The first 10 minutes of your first reading with us only costs $5.
Sometimes the stress and confusion can lead to violence and abuse in relationships. You become trapped and ensconced in Spiritual Chains! Abuse can be mental, verbal, physical, sexual, spiritual or even financial (e.g. he doesn't give you enough money to feed your family). If you are experiencing violence or abuse, get help now! You deserve to be treated with love and respect!
The Tarocco Siciliano is the only deck to use the so-called Portuguese suit system which uses Spanish pips but intersects them like Italian pips.[13] Some of the trumps are different such as the lowest trump, Miseria (destitution). It omits the Two and Three of coins, and numerals one to four in clubs, swords and cups: it thus has 64 cards but the ace of coins is not used, being the bearer of the former stamp tax. The cards are quite small and not reversible.[9]
The tarot can be used for many different purposes. The archetypal images on the cards reflect your story back to you, helping you to better understand a specific moment in time, and your greater journey through life. Those same images make good meditation companions or can provide you with a 'thought for the day.' There is no limit to how these images can be used.
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I believe that we co-create our future. When a psychic tunes in to you or someone else, they can pick up a lot of information about how you and that other person are feeling in that moment and what is going on for you and for them that might impact on the connection between you. They can also look further down the line and see what may happen in the future.
The illustrations of French-suited tarot trumps depart considerably from the older Italian-suited design, abandoning the Renaissance allegorical motifs. With the exception of novelty decks, French-suited tarot cards are almost exclusively used for card games. The first generation of French-suited tarots depicted scenes of animals on the trumps and were thus called "Tiertarock" ('Tier' being German for 'animal') appeared around 1740. Around 1800, a greater variety of decks were produced, mostly with genre art or veduta. Current French-suited tarot decks come in these patterns:
Love & relationship psychic readings can be used during any stage of a relationship. You do not have to be married or in a committed, long-term relationship in order to gain insight from a love-oriented psychic reading. Some people are surprised to learn that you can even talk with a love psychic guide when you are single to see if romance is just around the corner. You can ask for love advice before you officially start something with a potential partner. A quick reading before heading out on a first date can give you a picture of what the evening has in store for you as you meet and get to know this other person. Established couples can benefit from readings as well. You can ask for love & relationship advice whether you're experiencing anxiety or relationship problems due to challenging times or if your romance status is happy, stable, and in tip-top shape.
I have been fortunate enough to work with trance mediums, one especially gifted one, in a therapeutic context for several years now. I personally feel we truly know next to nothing about the mechanisms behind trance channeling and mediumship. Like Edison said, "We don't know one millionth of one percent about anything." I do think it's far more likely to be an integrative both/and rather than either/or pheonomenon with respect to subconscious production vs spirit speakers (to say nothing of tapping the collective unconscious) and that's about all I feel reasonably sure of. Quantum (Unified Field)theories/New Paradigm Science and the like holds promise as far as cracking the code on the the entire spectrum of super-normal phenomena. The study here sounds rudimentary. I would suggest interested readers see the research being done at Windbridge Institue, the Rhine Research Center, and IONS.
A former skeptic & private investigator, Bob Olson has been an Afterlife Investigator & Psychic Medium Researcher since 1999. In his search for evidence of the afterlife, Bob has tested hundreds of psychics, mediums & other afterlife-related practitioners. Bob is the host of AFTERLIFE TV, founder of BEST PSYCHIC DIRECTORY and BEST PSYCHIC MEDIUMS, and offers his PSYCHIC MEDIUM WORKSHOP to help psychics and mediums improve their abilities and business. Visit Bob on AFTERLIFE TV's FACEBOOK page & on TWITTER. And don't miss Bob's new book titled ANSWERS ABOUT THE AFTERLIFE.
My sister and I both realized our gifts and then discovered from speaking with our father that his father's brother was an acknowledged psychic in Rome, Italy. And then I also realized I could read hands and what I would see would surprise everyone and what I would predict would happen. I was really surprised at what I was able to read off the hands of my friends.
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When the spirit of a loved one visits us, they do it for one simple reason: because they love us. Think of it like this: If you passed your beloved grandmother on the street, wouldn't you stop and say hi? Even though they are in another dimension, they still experience, know, and understand the world we live in, and they love us and want us to know this. So look for signs from them.
Welcome, cosmic warriors. I'm Aliza Kelly Faragher, Allure's resident astrologer, and this is Aliza's Allure Astrology, a column dedicated to astrology, esotericism, and all things magick. (That's not to be confused with magic, which has more to do with entertainment — think pulling rabbits out of hats — than inner growth.) In each installation, I'm taking a closer look at an otherworldly subject, exploring both important celestial events and time-honored traditions of the occult. Today, we're getting acquainted with the ancient art of taromancy, or divination through the use of tarot cards.
The first documented tarot packs were recorded between 1440 and 1450 in Milan, Ferrara, Florence and Bologna when additional trump cards with allegorical illustrations were added to the common four-suit pack. These new decks were called carte da trionfi, triumph cards, and the additional cards known simply as trionfi, which became "trumps" in English. The earliest documentation of trionfi is found in a written statement in the court records of Florence, in 1440, regarding the transfer of two decks to Sigismondo Pandolfo Malatesta.[6][7]