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Oct 18
Posted by staidansns
25 New Junior Infants joined St. Aidan's this September. They are looking forward to learning new and exciting things throughout their years here in St. Aidan's.
Posted on October 18, 2016, in Uncategorized. Bookmark the permalink. Leave a comment.
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On an afternoon in the BTV Lodge, Alice Talbert is teaching a line dancing class, leading a group of residents through a series of heel switches and hip bumps to the sounds of two-step anthems like "Achy Breaky Heart" and "Elvira."
In jeans and a pair of Mary Janes, Alice calls out steps while her husband Ron, in khaki shorts and sneakers, alternately spins iTunes from a laptop setup, then jumps back in line to join the other dancers.
BTV residents since 2017, Ron and Alice Talbert caught the line dancing bug in South Texas, where they vacation for three months out of every year. Back home at Butterfield, they pitched the idea of starting a line dancing class for BTV residents.
"We thought if we learned how to line dance well enough in Texas, we could bring it back to BTV and have the best of both worlds," Ron said with a chuckle. "We'd teach the class and still be able to keep dancing."
Active retirement looks different on everyone, and on the Talberts the look is multi-faceted. Dancers, campers, Razorback fans, travelers, exercisers, parents, mentors – they do it all.
Ask them and the Talberts will say their top priority is spending time with friends and family, including three grown children, four grandchildren and four great-granddaughters – while making the most of life.
This includes traveling to places like Destin, Florida, and camping on the beach, taking their RV to the Missouri State Fair every year in Sedalia, and tailgating at Arkansas Razorback games. With strong connections to the UA – Ron is a retired UA professor with a notable career in Weed Science – Ron and Alice have been season ticket holders for Hogs football, basketball and baseball for many years.
They are such avid fans, in fact, that one year during football season, they, along with longtime friends Jim and Doris Barrentine, drove their motorhomes to every single out-of-town stadium in the Southeastern Conference.
You could say that Ron and Alice Talbert are renaissance retirees. Life is their oyster and they are thriving in their Golden Years.
Living at Butterfield gives residents like the Talberts added flexibility, the ability to travel more, be on the move and wake up in a new place whenever they want. When they are home, they love taking part in Village activities — tai chi, chair yoga, swimming, water aerobics, ping-pong, hiking, Margarita Monday, and now line dancing.
But, they are often on the road. Each year after the Christmas holidays, the Talberts pack up and head to Weslaco, Texas, to their part-time home in the breezy, balmy locale of the Rio Grande Valley.
Part of an annual wave of retirees who spend the winter in South Texas, the Talberts own a manufactured home in a trailer home resort in Weslaco. They spend a leisurely January through March relaxing and playing in the company of longtime friends they've known through their 22 years of visiting. Friends Ed and Jane Piper, also BTV residents, have accompanied them several times to Texas.
"The trailer resort we live in has all kinds of entertainment, card games, happy hour, line dancing, pot lucks, lots of socializing," Ron said. "This part of Texas is only about an hour's drive from Padre Island. It's on the same latitude as South Florida, so you can imagine how warm and soothing it is."
Since they returned home from Texas this spring, the Talberts haven't exactly laid low. In June, they joined a group of residents on a BTV Village Tours river boat cruise in France along the Seine River between Paris and Normandy. The group experienced a celebration of a lifetime by attending ceremonies to commemorate the 75th anniversary of D-Day at the beaches of Normandy.
The Talberts have also managed to squeeze in a few long weekends in their RV, while spending precious time with their children and their children's families, many of whom live in the area.
Daughter Vickie and husband David live in Vandalia, Mo. Her two grown children, son Ryan, his wife Jennifer and their three daughters, Ava, Lila and Isabelle, and daughter Brandy and boyfriend Josh, all live in Northwest Arkansas. So do son Philip, wife Lisa and their son, Christopher, his wife Gisela, and their new daughter, Annika. Daughter Cheryl, her husband Steven and their daughter, April, a high school junior, live a bit farther away in Prairieville, La., but the families visit often.
The Talberts arrived in Arkansas in 1963 when Ron accepted a position at the University of Arkansas as Professor of Weed Science in the UA's Department of Crop, Soil and Environmental Sciences.
As a young person, Ron became interested in agriculture, specifically soil and crop science, growing up on his family's farms in Toulon, Il., and near Vandalia, Mo. He earned an undergraduate degree in Soil Science at the University of Missouri, and stayed on at Columbia to earn a master's degree and Ph.D. in Weed Science.
Alice, who was raised in Mexico, Mo., was introduced to Ron by her cousin. Ron's friend, Jerry Maxwell was dating Janie at the time, so the two couples double dated. Both couples later married and remain close friends and travel buddies today. Ron and Alice were married on June 19, 1955.
When Ron was at Columbia, Alice worked at the University of Missouri's Library Catalogue Department. Once their three children were born, she stayed home. Alice belonged to the agri-wives Ph.T. Club (Putting Hubby Through Club) and typed both his master's and doctoral theses on a manual typewriter.
"I was so pregnant for one that I could hardly sit and reach the keys of the typewriter," Alice said with a laugh.
"We like to say we had one child for each degree," Ron added.
At the UA, Ron enjoyed a 42-year career as a successful weed scientist. His research included the behavior of herbicides in the environment and practical use of herbicides to control weeds in the variety of crops grown in Arkansas, such as soybeans, cotton, corn, sorghum and vegetables and fruits.
Internationally, Ron was part of a team of scientists who traveled to Egypt to conduct weed control in rice crops. And he worked in the Philippines teaching local farmers in underdeveloped areas how to apply herbicides to their mountainside corn crops.
Ron also taught undergraduate and graduate courses at the UA's internationally recognized Weed Science program. He and his students received many honors and awards over the years.
The Ronald and Alice Talbert Endowed Weed Science Scholarship is awarded to the most outstanding graduate student in Weed Science at the UA each year.
Alice has her own connection to the University of Arkansas. Once their children were in school, she accepted a position at the UA Athletic Department providing administrative support for the baseball and football teams.
To an avid Razorback fan like Alice, it was a dream job! She worked under various head football coaches, including Lou Holtz, and helped establish the coveted Diamond Dolls program for the UA baseball team. The Diamond Dolls are a select group of young women who help in the baseball program, sell media guides at home games and serve as bat girls.
"Coach (Norm) Debriyn asked me to help with the Diamond Dolls, and it was such a rewarding experience," Alice remembered. "To be part of the program at its inception and to see the group just keep getting better each year."
The Talberts were also active in youth center sports in Fayetteville, Ron with basketball, volleyball and men's slow pitch baseball. Alice played on a ladies softball team coached by Bill Brunner, who was a legendary Fayetteville High School coach and also a Butterfield resident. She is also a 26+ year member of the Butterfield Extension Homemakers Club.
To fulfill their spiritual needs, the Talberts are active members of First United Presbyterian Church, where they have served as elders, Sunday School teachers and youth sponsors.
Ron has also served as a Stephen Minister, a Christian layperson who becomes trained to provide one-on-one care to others in crisis. A Stephen Minister establishes a relationship with the person in need, visits and gets better acquainted with them and listens.
"Alice and I have both learned how to be around people and listen when people seem like they need it," Ron said. "We try to live good lives ourselves and be responsible in our space."
It was through their church affiliation that the Talberts first learned of Butterfield. First United Presbyterian Church in Fayetteville was one of the five area churches that founded Butterfield Trail Village in 1986. Seeking to secure a worry-free future for themselves, with access to medical care and recreation, the Talberts set their sights on Butterfield.
"Because of our church, we knew about BTV's development and planned to move here since its inception," Ron said. "When the church was involved in the feasibility study, we were interested bystanders. We knew from the beginning this was where we wanted to be. We are now living the dream."
Recently, Alice and Ron's line dancing class performed for residents at the BTV Health Care Center. Health Care residents had a great time, clapping and stomping their feet with the music. Some of the nursing staff got up and danced in the line, too.
"I've never seen our dancers looking better," Alice said. "We encourage everyone to come out. It's good to move and good for the mind."
It's no surprise that Ron still loves to garden. He has a gardening plot at BTV where he incorporates the "no-till" gardening method.
"I'm a unique gardener in that I like to grow weeds," he said. "It's better ecologically not to destroy the organic matter with tillage. You let the vegetation remain on the soil surface to decompose naturally."
He tells a funny story about when he and Alice first moved to Butterfield. He signed up for a garden plot, but the only one available was currently overgrown and in need of attention.
"I was told, 'It's a weed patch'," Ron said. "And I said, 'Well, I'm the perfect man for that."

subset: commoncrawl


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GLOW Season 3 Episode 7 Recap
In the previous episode of Netflix's GLOW, the ladies went camping, and Ruth and Tammé convinced Debbie to bring her son to Vegas. In GLOW Season 3 Episode 7, Sam took Justine to meet studio execs in Hollywood, while Rhonda met Bash's mother, Birdie.
Married to the Title
Sam had called in favors to get Justine and him meetings with studio execs. One wanted to change too much of her script, including having Michael J. Fox play the female main character. Another exec only took the meeting to tell Sam off. He wasn't interested in even reading Justine's script. At their last stop, the exec wanted to make the movie as is. He loved it.
During the last meeting, Sam felt pain and shortness of breath. Justine wanted to celebrate with him, but he had her take his car to celebrate with her friends in town. He asked someone on the street to call an ambulance; he'd had a heart attack. The doctor advised him to quit alcohol and cigarettes and to exercise more. Sam was already doing that.
Back at the house, Justine was angry with him for ditching her. She'd wanted to celebrate with him since they would be making a movie together. Justine had stipulated that Sam would direct her film, which he hadn't realized. Sam agreed that they should celebrate together.
Debbie had brought Randy to Vegas. She worked in the hallway while he played. Jenny asked Debbie for a raise to compensate for her additional work on the costumes. Debbie went to Bash, who was resting his voice. She took the opportunity to yell at him that she could no longer trust him. He agreed to give Jenny her raise.
Randy wandered into the elevator and onto the casino floor. A man picked him up until Debbie found them. It was JJ, who had sat next to Debbie on the plane. He asked her to dinner. Though he was from Wyoming, Debbie called him Tex. They had an enjoyable evening, and Debbie asked if he wanted to come upstairs. JJ declined but wanted to see her again the next night. Debbie thought that was too fast.
Bash's mother, Birdie, came to visit and meet Rhonda. She was uptight and suspicious of Rhonda's motives for marrying Bash. Birdie took Rhonda shopping. Rhonda confessed that she married Bash for a green card. Birdie had assumed it was for his money. Rhonda explained that Bash wasn't good with money, so she helped him. Later, Birdie revealed to Bash that, by marrying, he gained access to his entire trust fund of $40 million. In her own way, she seemed to approve of Rhonda.
What did you think of this episode of GLOW? Let us know in the comment section below!


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IMPORTANT UPDATE as of 1/1/2018:
ApolloniA was originally released on 8/18/2017. Since that time Soren of Luftrum Sound Design created a project to expand Lunaris to v1.2. This new version, released on 1/1/2018 includes all of the presets from ApolloniA, as well as an additional 130 brand new presets for a total of 150 new presets. I am going to leave the original page below because ApolloniA also includes 10 Multi Instruments that weren't included in the v1.2 update.
Lunaris v1.2 Announcement – Luftrum
Original ApolloniA release page continued:
Lunaris is Luftrum's first Kontakt sample based instrument, containing sounds from classic analog pads to lush ambient pads, cinematic pads and any pad in between, including 30 original Luftrum sounds created on Dave Smith's legendary Prophet-6. Lunaris also contains sequenced pads from underscoring elements to more contemporary rhythmic patterns plus a selection of dark, avantgarde and obscure pads.
At the heart of Lunaris are 2700 meticulously hand trimmed samples, collected in over 200 sound sources of multisampled pads, field recordings, synth transients and soundscapes available to mix, sculpt and shape into the perfect pad structure. But not only is Lunaris a dream pad machine, it is also a full bodied creative tool that can excel at anything from soundscapes to synth leads, as well as drones and organic textures, complementing both the producer, composer and the sound designer.
ApolloniA, for Luftrum's Lunaris virtual pad synthesizer, includes a complete set of 20 Single "snapshot" instruments and 10 Multi instruments. Programmed within the Lunaris Synthesizer Interface, along with the massive selection of available sound sources using no less than 4 Oscillators per patch, heavy use of Modulation Wheel routing, and the many parameters provided to create this unique sound-set. ApolloniA (Greek meaning: "From Apollo, Sunlight"), was created with one theme in mind …Ambient Pads of Universal Starlight, as follows:
Snapshots (Single Patches): Using 4 sound sources (Oscillators), per patch, from Synthesizer Transients & Core Sources, to Field Recordings & Soundscapes. Be sure to use the "Mod Wheel" for many sound transitions:
- Antarean Parallax – Echo Fantasy Pad <Mod Wheel Up> Echo Harp Pad
- Aurora Australis – Glittering Filter Swirl Pad
- Bright Equinox – 90's Bright Pad
- Comet's Tale – Sci-Fi Lead Rhythm <Mod Wheel Up> Soft Rhythm Pad
- Continuum – Atmospheric Soft Pad <Mod Wheel Up> Soft Synth Pad
- Cosmology – Fantasy Flute Voice <Mod Wheel Up> Fantasy Synth Lead Pad
- Deep Space Voyager – Synth Pad Rhythm <Mod Wheel Up> Deep Space Pad
- Event Horizon – Heavy Reso Rhythm Beat <Mod Wheel Up> Light Reso Rhythm Beat
- Jovian Poles – Soft Chaotic Attack Pad
- Kepler-186f – Planet Surface Landing Rhythm <Mod Wheel Up> Planet Surface Wildlife
- Nebular Emission – Glitter Synth Lead Pad <Mod Wheel Up> Reso Glitter Synth Lead Pad
- Pillars of Creation – Stellar Ambient Sweep Pad <Mod Wheel Up> Bright 90's Digital Ambiance
- Pleiadian Pro-6 – Blade Running Prophet 6 Pad <Mod Wheel Up> Prophet 6 Cinematic Pad
- Polar Star – Sharp Glitter Lead Pad <Mod Wheel Up> Soft Deep Space Pad
- Proxima Centauri-b – Soft Planetary Landing Pad <Mod Wheel Up> Planet Surface Atmosphere
- Solar Dynamics – Soft Solar Light Flow <Mod Wheel Up> Solar Rhythmic Flow
- Star Voyager I – Soft Brassy Lead Pad
- Star Voyager II – Blade Running Soft Brassy Lead Pad
- Stellar Halo – Crystalline Filter Lead Pad
- The Shores of Europa – Oceanic dreams of a distant Moon <Mod Wheel Up> Pad of Europa
Multi Patches: Selections from the above snapshots were used to create the following 10 complex multi patches:
- Callisto – Antarean Parallax + Jovian Poles
- Cosmic Rays – Nebular Emission + Continuum
- Exoplanet – Kepler-186f + The Shores of Europa + Proxima Centauri-b
- Galactic Nova – Comet's Tale + Bright Equinox
- Hearts of Space – Pleiadian Pro-6 + Cosmology
- Northern Sky – Aurora Australis + Polar Star
- Solaris – Solar Dynamics + Stellar Halo
- Star Voyagers – Star Voyager I + Star Voyager II
- Stellar Winds – Pillars of Creation + Stellar Halo
- The Speed of Light – Event Horizon + Stellar Halo
Installation Instructions: Locate the Lunaris folder on your hard drive. Place the included folder named "05. Apollonia by Ambietica", into the "Lunaris\Snapshots\Lunaris" folder on your hard drive. Then place the included folder named "Multis" into the "Lunaris\Instruments" folder on your hard drive :
- 05. Apollonia by Ambietica —> Lunaris\Snapshots\Lunaris (20 snapshot "single" Instruments)
- Multis —> Lunaris\ (10 "multi" Instruments)
After installation you should see both the "Snapshot" and "Multi" instrument selection within the menu structure pictured below (click image for a larger view):
ApolloniA Requirements:
- Kontakt version 5.6.8 and above
- Luftrum Lunaris: http://www.luftrum.com/lunaris/
Sound Demo of 6 out of the 20 included Snapshot Patches
Sound File Summary of Terms
The files you are about to download are provided free and as is, no warranty or support implied or otherwise. The archive is also password protected. To gain the password, please leave a personal "thank you" message within the "comments" section below with a valid email address so that I may provide the archives password for you.
This ensures a proper count of the users who download, and use these sounds. Your email address will NOT be used for any other purpose than to gain the archived password. Thank you for understanding, and I sincerely hope you enjoy making music with my sounds.
Kontakt © 2017 Native Instruments
Lunaris © 2017 Luftrum
ApolloniA © 2017 Michael Lyon


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In the kitchen – Alison Wong's As the Earth turns Silver
Just chomping through old notes and articles again…
One of the things that struck me about As the Earth Turns Silver was the way politics were filtered through the domesticity not only of Katherine, but also of Yung and other characters… the presence of the kitchen in this novel reminded me in some ways of Laura Esquivel's Like Water for Chocolate. The politics of the kitchen collide with the politics of nation formation in both novels…. Anyway, I just found an old article on exactly that feature of Esquivel's novel …
Some time ago, Tony Spanos wrote: "In Esquivel's Like Water for Chocolate twelve recipes for traditional and delicious Mexican dishes make up the narrative flow, during which the protagonist, Tita de la Garza, learns and shares the secrets, struggles and beauties of life in the kitchen. Even though some critics dismiss this type of Mexican narrative frame – in particular the use of recipes – as completely lacking in literary value and attempting only to be different – I find Esquivel's novel to be extraordinarily original, totally different from what any other Latin American woman writer has done, until now. That is, it seems to me, she wrote Like water for chocolate as from a second uterus, which is the kitchen and it becomes different conflicting metaphors throughout the novel. / Although this type of novelty may appear highly incompatible to many feminist critics, other women writers and women in general whose message is to reject patriarchal dominion and to move beyond the confines of domestic life, Esquivel reclaims the kitchen as a very serious domestic sphere which is the most sacred place in the house, and from which the protagonist controls her destiny through her recipes." (p.30)
"What Esquivel does in Like Water for Chocolate is to reclaim the kitchen as a place or space of artistic and creative power and not just a place of mere confinement and oppression." (p.32)
This reclamation fits within a trend, or movement, that Spanos refers to, writing (in 1995, BTW): "Even though, on the one hand, there is a literary precedent of domestic imprisonment of women in the kitchen and what this domesticity implies, on the other hand there are Latin American women writers who have proclaimed the importance of the kitchen in their works during the past ten years or so. In a conference that took place in 1982 on Latin American writers at Mt. Holyoke College, several of the participants and writers spoke about the importance of the kitchen in their presentations. The conference proceedings were published in 1984 under the title La sarten por el mango, The Frying Pan by the Handle, with editor Patricia Elena Gonzalez's metaphorical challenge to return to the kitchen and start writing." (p.31)
"The kitchen changes from a place of drudgery to an apprenticeship in an artisan's shop. Like an artist she records the recipes, along with their accompanying anecdotes and her own story. Now she understands the direct relationship and association between the recipes and the expressions they communicate about life while they are being prepared. Esquivel appears to be offering and recommending different recipes, codes and expression to describe and establish other references about knowledge and identity." (p.33)
"In Like Water for Chocolate repressive societal traditions at times control and dominate Tita's destiny. But Esquivel bestows on Tita the transformative power as an artist in the kitchen, by having her express and share her creative and magical recipes into a powerful and beautiful narrative. The author also celebrates the creative force and importance of the kitchen as a place providing a liberating voice…." (p.35)
Ref: Tony Spanos (1995) 'The paradoxical Metaphors of the Kitchen in Laura Esquivel's Like Water for Chocolate' Letras Femeninas XXI, No.s 1-2, pp. 29-36
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This dinner was one of our favorite events of 2018. Beverage Director Paula DePano recalls the evening course by course and sip by sip. Enjoy!
I have to admit that when the Triangle got hit by a snowstorm on the weekend before the Billecart-Salmon wine dinner, I was convinced that the event was cursed. The wine dinner was initially scheduled to happen on the 13th of September but had to be canceled the last minute due to Hurricane Florence deciding to 'rain on our parade' that day. Thankfully, the North Carolina sun gave us some sunny support and thawed the ice and snow in time for a fantastic dinner attended by more guests than the original date had!
The evening started with hors-d'oeuvres – Rutabaga Bubble and Vache Cheese Custard with Umeboshi Plum – enjoyed with the Maison's Brut Reserve offering. Clement Calleja, the US Eastern Regional Manager of Billecart-Salmon, co-hosted the evening with me. It was a such a pleasure having a charismatic and knowledgeable guest for the event.
With Chef Bedford helming the kitchen, the dinner started with a refreshingly tart Scallop Ceviche paired with the Blanc de Blancs, with grapes harvested from five Grand Cru vineyard sites. It was a perfect marriage of fresh, briny, and apple-ly favors.
Clement and I collaborated on the second pairing after I urgently asked his input as I was unsure of what to pair with the Foie Gras terrine for the second course. We were only supposed to showcase five wines, but his suggestion of pairing an Extra Brut champagne with the rich dish contrasted textures beautifully as well as highlighting the crunchy Bartlett pear component of both the food and wine.
The third course was our take on a surf and turf featuring butter poached lobster and braised beef cheeks, with the addition of winter truffles. Richrich, rich flavors needed a wine that can hold its own and yet somehow elevate them both together. The Brut Sous Bois, a cuvée vinified entirely in oak had buttery and toasty notes that seamlessly joined all flavors together. It is a wine that was an immediate hit throughout the dining room.
Cuvee Nicolas Francois 2002 is one of the three prestige cuvées of the Maison, created in 1964 as a tribute to its founder. All the grapes harvested from Grand Cru sites and partially vinified in oak casks giving the wine a generous and mineral character. Its ability to age for the next 20-30 years is apparent with its bracing yet harmonious acidity. Even in its 'youth,' the wine is very giving, and we absolutely cannot wait to see its evolution and eventual full potential. Paired with the gorgeous wine is one of Chef Bedford's favorite proteins to work with – Venison. Along with roasted parsnips, savoy cabbage, and Madeira, it was a dish that did justice to the wine's complexity.
Out of all of the wines from Billecart-Salmon, their Brut Rosé is their most recognizable. It is one of my favorite NM rosé champagnes in the market with its sinuous texture and bright fruit flavors. It was paired with a bittersweet chocolate cheesecake topped with hazelnuts, vanilla, and clementine. The candied clementine gave the wine and dessert the perfect bridge, tying the all bold and vibrant tones together like the perfect ending for the evening.
The Fearrington House Team all had such a grand time planning and executing this wine dinner. We absolutely cannot wait for our next wine dinner! I am so thankful to spend the evening with fellow "bubble-heads" who share my philosophy that Champagne absolutely goes with everything. #ChampagneAllDayEveryday


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King Bull prepares to hit stage with album release
With a new name, new music and a new serious attitude, King Bull is looking to take the central Alberta rock n' roll scene by the horns.
On May 31, the band formerly known as Sweet Grass, comprised of Lacombe drummer Alex Adamson, guitarist and vocalist Tucker McMurray and Bassist Aiden Ace Beauchamp, will hit the Bo's Bar & Grill stage in Red Deer for the 7" vinyl release of their debut single "Sha-na-na" ahead of a western Canada tour.
The release is their first under their new name, promising to deliver a true, genuine rock n' roll sound some believe has been lost in the modern music era.
"It's just rock n' roll music," said Adamson. "We've been compared to the newer stuff from The Hives…Jack White – we got a lot of comparisons to him.
"It's just loud guitar, loud everything – full force."
"Sha-na-na," an upbeat, fast-tempo song that will likely have toes tapping, hands clapping and people singing along with the repeating question of "Who are we trying to be" certainly has all those vibes.
The band originally formed in Blackfalds in 2016, but the members were by no means strangers, having grown up playing in a variety of bands all the way back to their early grade school years.
Just a few years ago, however, Adamson and McMurray started jamming together just for fun, which progressed to songwriting. They enlisted Beauchamp as their bass player and soon they were performing together.
Billed as a "power trio" they were among several opening acts during Lacombe's Canada 150 concert that Gord Bamford headlined at MEGlobal Field.
At the time, however, Adamson said they weren't as serious as they could've been as a band. When they recorded a demo in 2017 under the name King Bull, however, they decided the name would fit the band more. As of February, they've officially rebranded.
"It suited the band a bit more," said Adamson. "The other name has too many other associations and doesn't sound like a band."
Slowly, he says, they're disassociating with their old name, and their 7" vinyl release at the end of the month will be another step forward.
"Nowadays, everyone's releasing singles but they're not releasing them in physical form," said Adamson. "We just appreciated being hands on – it feels better to hold on to your favourite album as opposed to just looking at it on a screen.
"Just the whole taking it out of the package and putting it on, it makes you pay attention to it more."
Admission to the show is $15, and tickets can be purchased at Bo's, or any of the band members or members of the opening act, The Humble Cartel.
The band is also collaborating with The Troubled Monk to create a limited edition cask for the showa and be on The Drive 106.7 on May 25 and 26.
The release show will kick off a tour for the band, which will see them travel across Western Canada throughout the summer months.
For more information on the band, follow them on Facebook at facebook.com/KINGBULLmusic/, Instagram www.instagram.com/kingbull_music/. Samples of their music can be found on Spotify, Apple Music, Google Play and YouTube.
Tour dates are as follows:
- May 31 – Red Deer
- June 6 – Saskatoon
- June 7 – Regina
- June 8 – Medicine Hat
- June 19 – Innisfail
- July 4 – TBA
- July 5 – Thorsby
- August 7 – Vancouver
- August 8 – Duncan
- August 9 – Nanaimo
- August 10 – Victoria
- August 15 – Lethbridge
- August 16 – Calgary
- August 17 – Edmonton


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Georgian College is one of Ontario's fastest-growing colleges, offering education to 11,000 full-time and 28,000 continuing-education students across seven campuses in central Ontario.
With such a large student population, the IT department was facing increasing challenges with the incident and change management processes. Although they had a ticketing tool in place, it was simplistic and not sophisticated enough to differentiate between incidents, service and change requests.
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Royal Holloway University of London has a 135-acre campus in Surrey near London, England, with 19 academic departments teaching some 9,000 students, including 2,000 postgraduates.
The University wanted to change the way it provided IT services to users in order to deliver the same experience and choice found on consumer websites alongside some method to deliver technology that focused on end user needs.
Green House Data helped build a hybrid cloud architecture combining Hyper-V virtualization, Microsoft System Center 2012, and Microsoft Azure workloads. Royal Holloway University of London now provides public cloud workloads so users can simply visit the self-service portal and fill out an online form instead of inundating the IT department with requests. The IT department is now able to focus on new initiatives.
The London District Catholic School Board (LDCSB) serves 18,000 students in 45 elementary and 9 secondary schools in the counties of Middlesex, Oxford, and Elgin.
LDCSB needed a complete Information Technology Service Management (ITSM) tool to manage requests through a single point of entry and automate business practices to track requests received from the 54 schools. They also needed a way for remote field engineers to access the ITSM and track their work items.
Green House Data worked with LDCSB's IT team to understand their needs, designing and implementing System Center 2012 Service Manager to deliver a service request fulfillment solution that aligns business and IT strategies while ensuring IT services provide real business value. A self-service, web-based analyst portal was also created to help remote field engineers fulfill their tasks.


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Rollits recommended in 17 different practice areas in
29th edition of the UK Legal 500
Rollits has once again recognised as one of the leading law
firms in the Yorkshire and Humber region according to a survey the
UK's top 500 law firms, receiving acknowledgement as a leading
specialist in 17 separate areas of law.
The firm has been highlighted as a TOP-TIER FIRM in Yorkshire
& the Humber in four core areas: Commercial Litigation, Corporate & Commercial, Commercial Property and Employment.
In addition Rollits is the only law firm outside Leeds and
Sheffield to be recommended for its work in its niche areas of
Planning, Education, Pensions, IT & Telecoms and
Social Housing.
Comments which have been published in the guide include: -
Other areas of recommendation include Banking & Finance, Construction, Charities, Personal Tax, Trusts
& Probate, Intellectual Property
and Property Litigation.
19 lawyers at the firm have been recommended in the editorial
for their work as leading practitioners in their specialist
Managing Partner Ralph Gilbert said: "It is wonderful to be
recognised by the UK Legal 500. The recommendations highlight the
expertise we have within the firm and it is a real testament to the
hard work of the whole team here at Rollits that we feature so
highly in the rankings.
The Legal 500 is an independent guide to law firms in the UK,
based on in-depth market research, positive client feedback and
interviews with lawyers, solicitors and barristers.
This article is for general guidance only. It provides useful information in a concise form. Action should not be taken without obtaining specific legal advice.
Sign up to receive email updates and regular legal news from Rollits LLP.


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This is the story of Ultima Underworld told by Paul Neurath, a 20-year veteran of the interactive entertainment industry. In 1990 he founded Blue Sky Productions, which was later renamed to LookingGlass, and became a leading US game development studio. As Creative Director of the studio, Paul designed and directed the development of such acclaimed titles as Ultima Underworld, Terra Nova, Flight Unlimited, and Thief, which collectively earned over a dozen game-of-the-year awards. In this forum post I dug up, he talks about the making of Ultima Underworld – a pioneering breakthrough in gaming technologies, including 3D texture mapping and photorealistic terrain.
Hungry for more? Here's a link to an extended interview with Paul Neurath and Doug Church about the making of Underworld.


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Price: $20.00
Quantity: 1 available
Octavo Size. Near Fine copy. No dustjacket as issued. Laminated pictorial boards. Illustrated with Black & White Photographs and Drawings. 232 pages An undergraduate memoir of Trinity College Oxford during World War Two. Includes an Index.
Title: Oxford at War
Categories: Biography,
Edition: 1st Edition
Publisher: Northbridge, Western Australia, Access Press: 1996
ISBN Number: 0949795925
ISBN Number 13: 9780949795922
Binding: Hardback
Item: 1.00 Item
Seller ID: ID124949
Keywords: Autobiography Biography John Harper-Nelson oxford,


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12 per pack. Priced per unit.
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$0.31 – $1.37In Stock
12 per pack. Priced per unit.
There are no reviews yet.


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I am completely satisfied with the way Fisher & Associates handled my insurance settlement. My case was small, but I was treated with respect and courtesy. Every single step was explained to me as the case progressed, and my concerns along the way were always taken seriously.
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Its coming up to the end of the fencing season and news has been thin on the ground of late on this site as we have all been slightly busy with our lives. Nonetheless this masks the fact that this has been perhaps a bit of a corker of a year for the club. Not just the trophies and the silverware (more on those later), but for the fact that we have seen a number of new faces join our club, both in the junior and adult section who have made excellent progress and who are treading on the toes of some of the long term members who will have to up their game.
The other side of fencing, beyond technical excellence is competition,and this year Sutton Coldfield Fencing Club has raked in a number of gongs, punching once again above our weight, (or thrusting beyond our reach!)
Tomas Kazik
Shropshire Open – epee – Gold
Cocks Moor Epee Open – epee – Gold
Birmingham International Open – epee – Silver
West Midland Senior Championships – epee – Gold
Imogen Blackley
West Midlands BYC – Foil – Gold
West Midlands Senior Championships – Foil – Bronze
Oliver Nash
West Midlands BYC – Foil – Bronze.
Tomas Kazik, Dave Cox, Julie Foster
Presidents Cup (mixed team three weapon) – Champions
Plus Gavin Rudge achieved his Level 2 BAF Coachng award.
The victories and accolades above are not the full story however, because while we have had our share of successes this year we have also had many fencers who have taken or continue to the plunge into competition, and not just from the senior club, like Charles, Waiman and Archie who do continue to do us credit.
Imogen, Oliver and Danielle were selected to the BYC finals in Sheffield, which is an awesome achievement. We should also we should point out the achievements of our Junior fencers, many who competed in their first regional british youth championships and and represented their club.
To round off its been an excellent year for us, and as the summer approaches we begin to look forward to another year, to sharpening our newer blades for next year and perhaps teach thinking of teaching you some new tricks – without forgetting the basics of course! On a final note I would like to thank Archie for helping me Gavin and Julie with the youth section. Has the reflexes of a cat and eyes of a hawk, which you kind of need with the kids.


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What you need to know
Now your pet can pretend to be a Yeti or a Bigfoot: the harness is trimmed with colourful, comfy, warm Mongolian fake fur and lined with short imitation fur. Now you can combine the safety of the Bigfoot harness with the warmth of a dog's jacket.
The tag on the back has been attractively engraved with the Inamorada logo.
Fake fur and imitation fur lining.
XXS: length approx. 60 cm
XS: length approx. 70 cm
S: length approx. 80 cm
M: length approx. 90 cm
Weight: 0 kg


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América torna-se uma nação melhor quando juntos dizemos não ao racismo, ao ódio e à intolerância. #AmericaTogether
Why this title, you ask? I invite you to see the link below - "About This Blog" NOTE: All anonymous comments are deleted
Friday, February 19, 2016
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Having tasted my first home brew and thought it was slightly better than expected, I felt that, for my Christmas brew, I should try something a little more special. Whilst in my local home brew shop (very knowledgeable owner), I saw two Courage kits. One of them was a best bitter (generally what I go for in a pub), and the other was Directors, with its distinctive purple branding. It was a tough choice – go for the one I would order in a pub, or the one that I have a little more history with?
In the end, history prevailed, and I went for the Directors. This kit was over twice the price of my first brew, but after all, it is for Christmas, and besides, I fancied something that is quite a bit more than "drinkable".
It is currently bubbling way quite nicely in the fermenter. I must say, to begin with it was so vigorous that the water from the airlock went all over the top of the fermentation vessel. Even as I write this, I hear the periodic glugging of the airlock. There is also quite a thick layer of sediment forming on the bottom of the vessel (look closely at the bottom of the vessel in the pitcure – it is the light colour at the bottom on the left). I shall rack the beer into a second vessel, let it settle, then bottle half and keg the other half. Yes, I am a little excited about this brew!


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The Wine Wrote This EP by Ghanaian-Liberian Spoken Word Artist Dzyadzorm will be released on February 1, 2017.
The 6-track EP features collaborations with Poetra Asantewa and Ria Boss. It addresses issues including Love, femininity and identity .
"I used wine as a metaphor for openness and honesty. I think you'd agree with me that most of us are in our truest form when inebriated. We tend to become more expressive and direct when communicating. That's what TWWT is about; allowing my mask to come off and being open and unashamed of my flaws and insecurities while still not neglecting my positive attributes." says Dzyadzorm on what inspired the title of the EP.
She also speaks on what the goal of #TWWT is: "My entire journey with poetry has been about the understanding that my voice too is valid and ultimately reaching as many people as I can, hopefully make some sort of difference in their lives."
Dzyadzorm is one of the many talented artists in the Ghanaian Spoken Word/Poetry community.
Born Vanessa Akua Medie, her journey as a Spoken Word artist began with the writing of her own pieces as well as watching performances of J.Ivy, Black Ice, and Sunni Peterson, which encouraged her to give Spoken Word a shot.
It's been 4 years and counting since her first performance on Y FM's Poets on Y FM.
So far, she's performed at Jojo Abot and the Phunky Phew concert, Ehalakasa Talk Party's
Pepublikasa, Open Mic Night at N'Daba Music & Acoustic Poetry, Live In Accra Jazz festival and Elikplim Akorli's book launch for A Heart's Quest.
Her debut spoken word piece was Phases an expression of self-growth, pain, and a resolve to transform. She followed it up with Hush, a piece on the confusion that can sometimes surround female sexuality.
What other issues does she address in her pieces? "Mostly social issues stemming from personal experiences and aspirations. My plan is to expand my horizon as far as themes are concerned in order to be seen as a diver artist rather than a just a romantic one. One of my pieces I'm most proud of is War and its implications on a body of people."
Dzyadzorm's main goal is "to be better. Live better, write better, and perform better. I believe that the opportunities to go beyond Ghana and Africa will present itself."
By: livefmghana.com/Ghana/91.9FM


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He likes four sugars in his hot chocolates and he loves a margarita pizza. When he can't get pizza, he will settle for a Brie, bacon and cranberry baguette (Phwoar, Brie's nice isn't it? He asked me, as if he had never tried it before). He has a warm northern twang that feels like home (don't all northern twangs?) and he's grown a beard that Wolverine would envy.
There's one fact about Tom that I have neglected to mention (aside from the lopsided beanie he wore on his head and his struggle to make eye contact or speak above a murmur). Tom is homeless. He has been homeless for a few months now after a redundancy followed by arguments with a dodgy landlord. He approached me in Brighton station and asked if I could give him money for some food. I've seen the ads in tube stations about murdering the homeless with change (I've made that sound dramatic but if you've seen the ads, you'll remember the pictures). So I took him to Upper Crust and got him his extremely sugary hot chocolate, with extra whipped cream, along with his Brie baguette.
I had asked him a few questions (the ones you have read the answers to) and it was when I specified 'large' on the hot chocolate front that he said, 'Thank you so much,' as if I'd just handed him a thousand pounds. And then: 'How are you anyway? Are you having a good day?'
Yes, I replied, surprised and humbled by the fact that he'd asked. I'd been feeling ill and grim all day and had just had an interview (I ALWAYS get horribly nervous for interviews) but I wasn't about to say any of that. By his standards, I'd had an excellent day. I'd woken up in a bed after all.
Tom is quite a young man. Quite handsome under the beard. I asked him if he didn't have anyone he could stay with? No no, he brushed it off quickly to focus on the positive. He's working with the council in the summer. He'll have somewhere to live in the summer.
It is his chant, his mantra for now, and I hope it happens for him. But I think our lovely Tom will be sleeping in his car park for a while. Once you lose a home, how on earth do you get one back? The homeless are trapped by their own walls, despite a lack of real ones.
I passed him his cup of diabetes and his deluxe Brie baguette, complete with napkins (he already had cream in his beard when I left) and wondered, have I really helped at all?
'Thank you so so much,' he said again, and then: 'I love you' before I ran for my train.
Helped? Maybe. I had topped up his hope, at least. But for now, Tom will still call a corner of somebody else's car park his 'home'. And he will still declare love to helpful strangers, for lack of anyone else to feel anything for.
Emily Ford | @FordgotBored | 1lifelaughing


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mayo 20, 2020
Any-Grid Battery Inverter Charger PSW-B
(1.5kW/3kW PV, 3kW/5kW AC)
Any-GridTM Battery Inverter Charger The Phocos Any-Grid PSW-B Series (Pure Sine Wave Battery Inverter Charger) is part of Phocos' most versatile line of inverters/chargers. Flexibility and reliability are key characteristics of this product line, with a strong potential for cost saving opportunities in real world conditions. The PSW-B converts DC


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klumper.info: Buy KamaSutra Luxury Series Condoms for Men, Orgasmax (4in1) Condoms, Ribbed, Dotted, Durex Mutual Climax Condoms - 10 Count.
The Kama Sutra is about passion, attraction, desire, and pleasure. Women Should Orgasm First And Other Unexpected Kama Sutra Advice . but there should be a simultaneous value of your and your partner's pleasure.
You know about the Kama Sutra, but how about the Calmer Sutra? They achieve mutual orgasm thinking about how much money they saved.
If you've read the original Kama Sutra cover to cover it's an Kama Sutra needs several chapters devoted to R-E-S-P-E-C-T and mutual sexual.


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Over 2 meters of snow on Presena Glacier
Over 2 meters of snow on Presena GlacierThe ski runs will be open until June 28thPresena is one of the very few glaciers where summer skiing is also possible. A modern cable car takes skiers up to 2,585 m at Passo Paradiso: the gateway to the glacier which stretches upwards before your very eyes to […]
The winter-season keeps going also after Easter
Thanks to the last snow falls, the snow conditions in the Dolomiti Superski area for Easter will be great. Some of the ski areas will be open also after Easter. Take advantage of the special offers DolomitiSuperSun and DolomitiSuperKids which start on March 15 and spend a few days in the snow at great prices.


text: Death Penalty repeal gains momentum Mar 13, 2009 21:59:36 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by sandbagger1 on Mar 13, 2009 21:59:36 GMT -5 Just got an email that the New Mexico State Senate just passed a bill to abolish the death penalty. Since it has already been passed by the House, all that is left is for their drunk, corrupt, can't keep his hands to himself, governor to sign it. New Mexico has some nasty people on death row. Maybe, they will have another prison riot?


text:
To ensure continuity of service during the COVID-19 pandemic, all BCGEU offices are closed and staff are working remotely to assist members.
We recommend that you email the appropriate office if you require assistance.
Optional email code
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Burnaby, B.C. V5G 3W3
Phone: (604) 291-9611 /
Fax: (604) 291-6030 / 1-800-946-0244
Full Contact Details
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As limitless QE is about to unfold in Europe by Mario Draghi and the Federal Reserve with QE3 in America , cheap cash goes to start out working around the globe unchecked. Gold and silver costs will begin rising and rebounding less. … Read More


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Could they be the last of the season? I always thought Strawberries were a Spring thing, everywhere except England where they're a year round thing, it seems. Well, it's August, isn't it? And that's no time for Spring Chickens. But yet, there they were, sweetly fragranced, locally produced Strawberries, shining freshly under the market lights. And a bargain too! Why? What's the deal? Well, I gave them a good sniff, a prod and decided not to look a gift horse in the mouth. When I got home I popped one in my mouth and the flavour was every bit as good as the colour and smell. Too good to be true! These were almost the best Strawberries of the season, and here it's the middle of August. Those didn't last long, and I went straight back the next morning for another batch. Of course we ended up eating them with all sorts of things, but this was my favourite way:
Strawberry Sorbet
about 1½ cups strawberries,
washed and hulled
5 or 6 blocks of ice
¼ cup water
1 Tbsp or so lemon juice
3 Tbsp castor sugar
1 tsp Vanilla essence
-Place all ingredients in a blender and pulse until the ice has broken down.
-blend on high for a minute or two until the mixture is a good slush.
-place the mixture in the freezer.
-freeze for ½ hour at a time, remove from freezer and blend to break crystals. repeat 4 or 5 times before freezing.
-Remove from freezer 10 mins prior to eating and beat a bit to loosen the ice.
*try adding a couple Tbsp of your favorite alcohol to the mixture to prevent it from freezing so solidly


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Trevor Noah connects Donald Trump's 'rigged' election claims to reality TV
Donald Trump has spent the better part of the last week claiming the election is "rigged" against him as Trump continues to trail behind opponent Hillary Clinton in the race of the White House. Trump's claims — which he has repeated on social media — has left many commentators concerned about a possible legitimacy crisis, but as Trevor Noah smartly observed on Monday night, it likely comes from Trump's background in reality TV: The Apprentice, beauty pageants, pro wrestling.
"If you understand reality TV, you understand why Trump's world is falling apart," Noah said. "Think of it: In his mind, he should be winning. He knows he's the ultimate contestant, and if he isn't winning, then the contest must be rigged, because that's how reality TV works. And Trump knows this, because he's the one who did the rigging. When Trump made The Apprentice, he just fired whoever he felt like, and his editors would have to go back and re-edit the show just to make it look like his judgment had some basis in reality. Which, by the way, is what we'll have to do after he's president, you realize that. Trump will just randomly bomb Italy and we'll all have to be like, 'Well, I think it's because you guys put clams in the pasta? Let's go with that.'"
Watch the clip below.


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Barcode Scanning Apps: Quickbase Webinar
Barcode Scanning Apps Quickbase Webinar
I'm Rich Eicher Sr. I'm a founding member of the codeREADr team. I have a special announcement. CodeREADr was recently recruited to be a strategic partner by Intuit QuickBase. Below, learn about the new connection tool for barcode scanning apps, as well as an exciting webinar.
What is Intuit and what is Quickbase?
Intuit is a globally recognized company. Its products include TurboTax and QuickBooks. Intuit QuickBase is a cloud-based rapid-application development platform. Quickbase is used by 7,000 companies in 44 countries around the world. This platform allows you to build solutions for your business exactly the way you want, without code. CodeREADr is thrilled they are bringing attention to our product.
CodeREADr built a simple connection tool between our barcode scanning apps platform and QuickBase. So, now you can scan barcodes in to QuickBase, even offline. This means you can build the applications you need, then connect them with codeREADr's scanning and data collection apps. You don't need to learn how to code or learn APIs!
During QuickBase's webinar on October 29th, 2015, we told the world about codeREADr's new partnership. Attendees heard from codeREADr client Nancy Maciejeski. Maciejeski is the President of DM Event Service.
Maciejeski discussed:
- Challenges and lessons from implementing barcode scanning technology across her company.
- What led her to barcode scanning.
- Challenges with scaling the technology.
- Success metrics.
- Plans for further roll-out and improvements.
Webinar attendees learned:
- How barcode scanning apps are more affordable, accessible, and easy to deploy than ever.
- Scanning-use cases such as attendance check-in, asset/inventory tracking, and continuous information update/rewrite.
- The power of custom cloud applications to store, manage, and utilize your scanned data.
- A look at future trends in the barcode scanning industry.
We're excited to be an Intuit partner. We look forward to telling you more about our joint solution.
[fusion_social_links show_custom="no" /]
[fusion_social_links show_custom="no" /]
[fusion_social_links show_custom="no" /]


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'Bohemian Rhapsody' Wins Two Major Golden Globe Awards
And it will probably be up for Oscars too!
The biopic about Freddie Mercury and Queen, Bohemian Rhapsody, totally cleaned up at the Golden Globes last night. It won in both categories it was nominated for.
It won Best Motion Picture – Drama category, and actor Rami Malek won the title of Best Actor in a Motion Picture – Drama for his role as Freddie.
"I am beyond moved. My heart is pounding out of my chest right now," Malek said in his acceptance speech. "This is a profound honor to receive this, and to be counted among such extraordinary actors. I have to thank everyone who worked so tirelessly to make this film what it is. And of course, to Queen. To you, Brian May, to you, Roger Taylor, for ensuring that authenticity and inclusiveness exists in the music and in the world and in all of us. Thank you to Freddie Mercury for giving me this job of a lifetime. I love you, you beautiful man!"
"Now that was unexpected," producer Graham King added, while accepting the Best Motion Picture award at the end of the show. "The power of movies is that it brings us all together. Freddie Mercury and Queen did that so successfully through their music. To see that magic come alive, and to see the incredible response to this film has been truly humbling. A huge thank you to Brian May, Roger Taylor, and to Freddie Mercury – thank you for showing us the power of embracing your true self. This one's for you."
The film had stiff competition – A Star Is Born was a contender in both of those categories.
Malek is also expected to be nominated for an Oscar. We'll find out on January 22, which is also the day Bohemian Rhapsody will arrive for home viewing on digital platforms.
Main Image via Facebook / @BohemianRhapsodyMovie


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Oldfields News
Sparks-Glencoe's first annual Race For Green took off. The 5k race, 2 mile fun walk drew approximately 75 participants from all parts of Maryland and neighboring states to the NCR Trail. Support from the local community was essential to the success of the race.
Oldfields School fielded a team of cross-country runners, including the winner of the Under 15 Age category, Bibi McGill (left). The School also fielded a team of volunteers, whose enthusiastic cheering probably helped some runners shave a few seconds off their times.
Coming in first place with a time of 17:24 was Keith Lucas, of Phoenix, Maryland. The fastest female runner was Megan Van Den Hengel of Mechanicsburg, PA. We're grateful for the support of our sponsors, and for the additional prizes, provided by Hair Culture in Hereford, Kingsdene Nursery, and the Milton Inn. Many thanks to co-chairs Gina Navarro and Renae Olver for their hours of hard work organizing our first race.
Printed in the Sparks-Glencoe Community Planning Council
Fall 2011 Newsletter


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1) Service de Biochimie et Biologie moleculaire; U602 Inserm/Universite Paris XI; Hopital Paul Brousse, 14 avenue Paul Vaillant Couturier - 94804 Villejuif Cedex, Assistance Publique-Hopitaux de Paris ; France.
September 2006
Hepatocellular carcinoma (HCC) is among the fifth most common cancers worlwide. The geographic areas at higher risk are located in China and eastern Asia, middle Africa and some countries of western Africa. Lower incidences are encountered in Japan, Europe and America, but this incidence is still rising in part because of the high level of hepatitis C virus infection. The preponderance in males is universal and HCC is the commonest in subjects over the age of 40, although it can be observed in younger. The prognosis is generally poor, especially in Africans and Chinese where survival time may be as short as 11 weeks from the onset of symptoms. The causes of more than 85% of HCC cases are known (hepatitis B and C, aflatoxin B1, ethanol, metabolic diseases). HCC is an epithelial tumor developing from hepatocytes. In the majority of cases, cirrhosis is the major underlying risk factor, but HCC may occur also on chronic hepatitis or normal liver.
Mechanisms of hepatocarcinogenesis are not completely understood but, like most solid tumors, the development and progression of HCC are believed to be caused by the accumulation of genetic changes resulting in altered expression of cancer-related genes, such as oncogenes or tumor suppressor genes, as well as genes involved in different regulatory pathways. The genetic changes involved can be divided in at least 4 different pathways, each pathway contributing to a limited number of tumors. These are :
HCC is probably one of the tumors the etiologic factors of which are the best known. However, in spite of numerous studies and thousands of tumors analyzed, fractionnal data relative to the genetic mechanisms of hepatocarcinogenesis are known and genetic predisposition has been rarely described. HCC generally develops in the setting of chronic hepatitis or cirrhosis in which there is continuous inflammation and regeneration of hepatocytes (Figure 1).
Figure 1 : Sequential changes in the liver leading to HCC
Hepatocarcinogenesis may begin in preneoplastic lesions such as macroregenerative nodules, low-grade and high grade dysplastic nodules (Takayama et al., 1990; Orsatti et al., 1993). Accelerated proliferation of hepatocytes and development of monoclonal hepatocyte populations occur in all preneoplastic conditions. Accumulation of genetic alterations in these preneoplastic lesions is believed to lead to the development of HCC. Genomic alterations occur randomly, and they accumulate in dysplastic hepatocytes and HCC. Although genetic changes may occur independently of etiologic conditions, some molecular mechanisms have been more frequently related to a specific etiology. For example, molecular pathways of HBV- and HCV-induced hepatocarcinogenesis involving Rb1, p53, and Wnt families are different from those associated with alcoholism (Wang et al., 2002; Suriawinata et al., 2004, Morgan et al., 2004).
The important heterogeneity of genomic lesions found in HCC suggests that HCC may be produced by selection of both genomic and epigenetic alterations that compromise more than one regulatory pathway. During the preneoplastic stage leading to HCC, alterations concern mainly quantitative modification of gene expression induced by epigenetic mechanisms. Growth factor genes such as transforming growth factor a (TGF-a) or insulin growth factor-2 (IGF-2) are mainly involved. Dysregulation of these genes results from combinated actions of cytokines produced by chronic inflammatory cells that infiltrate the liver and the regenerative response of the liver, viral transactivation, or action of carcinogens. Genome-wide hypomethylation and aberrant methylation of genes and chromosomal segments are also observed. Expression of DNA methyltransferases which catalyze the methylation and demethylation of CpG groups is increased in livers affected with cirrhosis and chronic hepatitis (Lin et al., 2001). Cis- and transactivation of genes resulting from the actions of integrated viral promoters or viral transactivating molecules are other possible causes of epigenetic changes. For example, during HBV chronic infection, the HBx antigen binds and alters functionally tumor suppressor P53. Morever, integration of viral genome sequences may induce genomic instability and structural changes such as mutations, breaks or chromosomal rearrangements. These early genetic or epigenetic alterations are not sufficient to induce malignant phenotypes in hepatocytes. It is the accumulation of these events in critical combinations that allow the malignant transformation, several genes being simultaneously altered in each tumor.
instability (MSI) has been frequently
reported by different teams, including in liver cirrhosis, mainly when cirrhosis
is associated with HBV infection (Salvucci et al., 1996; Salvucci et al., 1999; Karachristos et al., 1999; Kondo et al., 1999; Kawai
et al., 2000; Dore et al., 2001). However, the frequency of MSI
in HCC exhibits large variations (10-43%) and high-MSI phenotype has rarely
been described (MacDonald et al., 1998; Chiappini et al., 2004).
It is still unclear whether some HCC have DNA mismatch repair genes alterations.
Allelic deletions, mainly in chromosomes 1p, 4q, 5q, 6q, 7p, 8p, 9p, 10q,
11p, 13q, 16p, 16q et al., 2002and 17p, or gains in chromosomes 1p,
6p, 8q and 17q are frequently observed (Thorgeirsson).This genomic instability
contributes to activation or inactivation of oncogenes or tumor suppressor
genes. In some cases, epigenetic changes directly precede structural alterations
in the same genes as it has been described for CDKN2A gene in 16q chromosome
or c-myc oncogene in 8q. Some carcinogens may induce specific alterations.
Indeed, aflatoxin B1 is responsable of a G/T transversion at codon
Table 1 . Main candidate tumor suppressor genes located in chromosomal segments with high level of loss of heterozygozity in HCC.
LOH Candidate genes
1p p73, RIZ (retinoblastoma-interacting zinc-finger protein)2p hMSH23p hMLH15q APC6q M6P/IGFIIR (mannose 6-phosphate/insulin-like growth factor II receptor)9p CDKN2A (ou p16INK4A, MTS1/p16)10q PTEN/MMAC113q RB (retinoblastoma), BRCA216p axine 1, SOCS-116q CDH1317p p53
Lack of control of recurrence and metastatic foci is the most prevalent cause of death in patients with HCC. HCC metastasis is probably initiated in the primary tumor and is a multigene-involved, multistep, and changing process. The molecular signature of primary hepatocellular carcinoma (HCC) has been found very similar to that of their corresponding metastases, while it differs significantly in primary HCCs with or without metastasis. These findings imply that many of the metastasis-promoting genes are embedded in the primary tumors and that the ability to metastasize may be an inherent quality of the tumor from the beginning (Budhu et al, 2005). Allelic losses have been proposed as being related to the survival and prognosis of cancer patients. Loss of heterozygosity (LOH) on chromosomes 13q, 16q, and 17p has been particularly associated with the progression of HCC. LOH on 16q has been identified as one of the most significant negatively predictive factors for metastasis-free survival of HCC patients (Salvucci et al., 1999; Okabe et al., 2000; Nishida et al., 2002, Gross-Goupil et al., 2003). Nevertheless, the genes altered have not still been identified. Metastatic process need intercellular exchange betwen tumoral cells and environmental cells such as endothelial cells or fibroblasts. Different molecules may be involved in these interactions. Some adhesion molecules are suspected to play a role in the metastatic process in HCC such as laminin-5 (Giannelli et al., 2003), variants of CD44 glycoprotein (Endo et al., 2000), or osteopontin (Pan et al., 2003, Ye et al., 2003). Proteins involved in the degradation of the extracellular matrix may also play an important role such as urokinase plasminogen ativator / plasminogen activator inhibitor-1 (uPA/PAI-1) (Zheng et al., 2000) or matrix metalloproteinases (Giannelli et al., 2002). Angiogenesis is critical to HCC since it is such a hypervascular tumor. Various angiogenic factors have been identified in HCC. In particular VEGF and its receptors have been demonstrated to be upregulated in HCC both at the tissue and serum levels.
P53 protein is a DNA-binding, cell regulating, transcription factor that has multiple critical roles in the pathway governing cell-cycle and in the balance between cell division and apoptosis.The p53 gene is the most commonly mutated tumor suppressor gene in various human cancers. The frequency and type of p53 mutations differ according to the geographic origin and suspected etiology of HCC. The specific codon 249 mutation has been linked to aflatoxin exposure in 36% of tumors from Africa and 32% of tumors from China, respectively (Ozturk et al., 1999). In contrast, the codon 249 mutation is seen in less than 4% of HCCs from Japan, Europe, and north America, where HBV and HCV, but not aflatoxins, are the main etiologic factors. Other codons of the p53 gene can be altered in HCC and overall this gene is mutated in 15% of tumors in Europe and 42% in China. The wild-type P53 protein can accumulate in HCC tumor cells by complexing with cellular or viral proteins (Bourdon et al., 1995). Experimentally, the HBx protein, encoded by the HBV genome, interacts with wild-type P53 and inhibit its function. Morever, P53 antibodies have been detected in the serum of HCC patients (Shiota et al., 1997; Saffroy et al., 1999; Charuruks et al., 2001). P53 alterations have been globally associated with poor prognosis.
b-catenin is a submembranous protein associated with E-cadherin and participates in cell-cell adhesion. It is involved in the Wnt carcinogenesis pathway. The Wnt signal inducing cellular proliferation implicates formation of a complex with axin, GSK-3b kinase and APC proteins and finally degradation of b-catenin. Dysregulation of the Wnt pathway inhibits these complexes and induces b-catenin stabilization. Translocation of b-catenin to the nucleus causes transcriptional activation of target genes, including the c-myc and cyclin D1 genes. Most of b-catenin point mutations alter 1 of the 4 serine or threonine residues which are targets for phosphorylation by GSK3-b and are crucial for down-regulation of the protein. b-catenin mutations have been found in 19 to 41% of human HCCs of different etiologies (de la coste et al, 1998; legoix et al, 1999). Clinical significance of intense nuclear localization of b-catenin in HCC is controversial (Terris et al. 1999; Hsu et al., 2000; Endo et al., 2000; Wong et al., 2001; Fujito et al., 2004). It has been shown that b-catenin mutations are more prevalent in HCCs related to HCV than HBV (Laurent-Puig et al, 2001). They have not been detected in non tumorous tissue, dysplastic lesions, and cirrhotic nodules. HCCs harboring b-catenin mutations have a limited number of chromosomal aberrations detected by microsatellite marker analysis (Legoix et al., 1999, Hsu et al., 2000, Laurent Puig et al., 2001) suggesting an independant mechanism of hepatocarcinogenesis. In mouse models of hepatocarcinogenesis, the incidence of b-catenin mutations is highly variable between tumors induced by different carcinogens (Devereux et al., 1999) or developed on different p53 backgrounds (Renard et al., 2000). Mutant b-catenin is not associated with metastases in HCC patients. This suggests that b-catenin mutation is an early event in hepatocarcinogenesis (Mao et al., 2001).
No mutations of APC gene have been observed in HCC, but other actors of the Wnt pathway may be altered. Indeed, axin 1 gene is mutated in about 5-10% of HCCs (Satoh et al., 2000; Taniguchi et al., 2002). Although frequent alteration of E-cadherin expression has been observed, no mutation of the gene has been found. Loss of E-cadherin function may be related to LOH associated with de novo methylation (Kanai et al., 1997).
Taken together, the b-catenin pathway appears to be altered in more than one third of the HCCs.
The Retinoblastoma (Rb) gene is involved in regulation of the G1 phase of the cell-cycle. It is the first tumor suppressor gene identified and one of the most frequently mutated in human tumors. Although Rb expression is frequently decreased in HCCs, mutations are observed in only 15% of the tumors (Ozturk et al., 1999). So inactivation of Rb may be further related to alterations of other interacting proteins such as p16-INK4. Both germline and somatic mutations of p16-INK4 have been found in HCC patients. But hypermethylation of the gene promoter (reported in about 50% of the tumors) associated with loss of heterozygoty seems here the main mechanism for gene inactivation. Other genes are less frequently altered. Cyclin D, A or E were shown to be amplified in 10-20% of HCCs. A surexpression of cdc2 has also been described associated with poor prognosis (Qin et al., 2002). Overexpression of p28/gankyrin, a gene involved in the degradation of Rb by the proteasome system, could also contribute to the metastasis potential in the process of hepatocarcinogenesis (Fu et al., 2002; Dawson et al., 2006).
Loss of the response to TGF-b, which induces both growth inhibition and apoptosis in hepatocytes, may also play a role in hepatocarcinogenesis. The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), involved in the activation of TGF-b and degradation of IGF2, is a candidate gene. But if loss of heterozygosity is frequently observed at 6q25, presence of mutations in the M6P/IGF2R locus, is controversial. SMAD2 and SMAD4 are intracellular mediators of TGF-b. Nevertheless, these genes appear to be mutated in less than 10% of HCCs (Yakicier et al., 1999). In contrast, no mutation of TGF-b receptor II was found in HCC. Overall, the TGF-b pathway appears to be altered in about 25% of HCCs.
By contrast to other types of cancer, oncogenes do not seem to play an important role in hepatocarcinogenesis. However, surexpression and amplification of c-myc (located in 8q) have been observed in some cases. Mutation of the 3 main ras genes have been observed in less than 10% of HCCs. Some K-ras mutations have been related to vinyl chloride exposure.
In conclusion, the number of altered genes in HCC is high, but the frequency of each individual gene mutations is generally low. The main pathways affected may represent individually a distinct step of hepatocarcinogenesis but they probably are related to each other. To date, our knowledge of the order of events for the initiation and progression of HCC is still incomplete. Prospectively, development of global methods of analysis such as proteomics or microarray methods will probably increase discovery of new genes or pathways involved in hepatocarcinogenesis.
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|de Biochimie et Biologie moleculaire, Hopital Paul Brousse, Faculte de Medecine Paris Sud, 94 800 Villejuif, France
|This paper should be referenced as such :
|Lemoine, A ; Saffroy, R ; Debuire, B
|Mechanisms of hepatocarcinogenesis
|Atlas Genet Cytogenet Oncol Haematol. 2007;11(1):65-70.
|Free journal version : [ pdf ] [ DOI ]
|On line version : http://AtlasGeneticsOncology.org/Deep/HepatocarcinogenesisID20055.htm
|© Atlas of Genetics and Cytogenetics in Oncology and Haematology
|indexed on : Sun May 10 17:23:18 CEST 2020
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Woahhh… I've been so lazy writing blog these days, I just don't have mood for write anything. Yeah, finally two days ago I was 23 years old officially !. All my best friends in boarding house and -someone who close to me over five years ♥- gather to gave me a surprise. It made me absolutely shocked but I also felt happy, awkward and shy. They gave me a very delicious chocolate cake, and beautiful gift. Hehehe. Oooh so sweet they are. I really loves and thankful with them a lot.
Honestly, I really didn't care about my birthday. Since I was kid, my parents never put a birthday party into something that you must celebrate. On my birthday, my mother would cook a special food or cake for me, and my father give me a lots of treasure advice to through the life. Thus, all their treatment made me into such a cold person plus I can't remember the day or date properly.
So mostly I always missed a chance to celebrate everyone's birthday and let go of their birthday without said anything. What kind of friend am I ?!. No, not I didn't care about them, but I didn't knew why I could be like this 😦 ! It really made me into the trouble. Oh everyone, I'm so sorry for my lack memories. All my friends already understand about it, so they didn't complain it. But, it made me reaally feel sorry. In the future, I will more considerate and make a note about important day, including the birthday everyone who closest to me. So please forgive me…
I am grateful to Allah Subhanahu wata'ala with His kindness and generosity I could live well until this time. Only with the permission of Allah Subhanahu wata'ala I could learn many things in this world and make me know the purpose of creating of mankind. Yeah, we created only to believe and worship to Allah. I feel blessed, I have many a nice people around me. My family, my friends, and -someone who close to me over five years ♥-. So many people that filled my life with happiness. I can't repay everyone's kindness but I'm sure Allah will reward all of you with the best way. Aamiin.
Since I getting older, I wish i can finish my final project (skripsi) and graduate next year. I wish I can worship to Allah more better, more diligent, and more sincere. And I want to continue to learn religious knowledge. I also want to be able to memorize some important verses in the Quran. I want to be a better person who can make my parents feel proud, and useful to others. I want to spread smile and happiness to everyone around me. I want to reduce my temper and keep my words to not hurt others. And hopefully everything I plan run well. Help and grant me Ya Allah. Aamiin.
So, after the sweet surprise they gave to me, I treated them to eat chicken noodle as an expression of thankful. It sounded cheap and not fancy ? hehehe, I don't have much money now, but I'll treat them in the better place to eat when I have more money. I promise. Aaahh, I feel so blessed and happy. I got a quality time with my boarding house friends, talk and laugh a lot. It's very good time.
Tagged: Grateful to Allah, have fun with friends, lovely gift, My birthday, my wish, very thankful


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Miles liked Bauhaus. He had a lot of their music on is computer. I liked them too, but not a lot. I think maybe we both liked them the same amount at the same age. It is an ominous unpleasant song. It's not for everyone.
Day 164: All We Ever Wanted Was Everything
I asked people on Facebook about what their most memorable Miles quotes are– what did Miles say that sticks with you? I got lots of great responses.
Kali said that Miles would say, "get up, eat jelly" all the time to her. I can imagine him fixating on that line, a weird line in a great song by Bauhaus. I think I heard him say it once or twice. I am sure I asked him what it meant, and I am pretty sure his response was, "get up, eat jelly." I did not understand but that's not the point.


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House To Rent in Shortridge Terrace, Newcastle, Grant Management, a 360eTours.net tour
LUXURY 3 BED HOUSE IN JESMOND Ideal for students, post grads or professionals wanting to share. Call to book a viewing or let us know your number so we can call you back. Modern kitchen, bathroom and furnishings. Spacious double bedrooms with bright and airy lounge. Includes dishwasher, washer dryer and power shower! Managed by Grant Management, an ARLA registered agent, 24-hour emergency service and part of the Tenant Deposit Scheme. Only a 20 minute walk to Northumbria and Newcastle University. Excellent transport links with regular buses into the city centre, as well as a metro station only 5 minutes walk away. There are also many bars, restaurants and shops within short walking distance. Suitable for 3 individuals. Photos and virtual tour taken at time of renovation. 'CONTACT GRANT MANAGEMENT TO FIND OUT WHETHER THIS PROPERTY IS AVAILABLE TO RENT'. Disclaimer: The information and photographic images contained within this video are provided for informational purposes only and were correct at the time of photography on 29/05/06 17:19:00. This data is deemed reliable but is not guaranteed. http://www.360eTours.net


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Meet Our Chamber Members
Want your business listed here? Click below to join the Bunker Hill Area Chamber of Commerce!
Charles Heinemeier Scholarship FoundationCharles Heinemeier Scholarship Foundation Contact: Andy Heinemeier
Our goal is to provide Bunker Hill High School students with scholarships for college.
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BEIN, daughter 1931
Posted By: Tammy (email)
Date: 8/27/2015 at 21:30:15
Mr. and Mrs. Wesley Bein had a baby girl born Sunday at the Deaconess hospital but it did not live. It was buried at Oakland cemetery Monday. Mrs. Bein was in a serious condition but later reports state that her condition has improved somewhat.
--The Grundy Register (Grundy Center, Iowa), 7 May 1931, pg 11
Grundy Obituaries maintained by Tammy D. Mount.
WebBBS 4.33 Genealogy Modification Package by WebJourneymen


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"Fascinating and often moving ... as much a story about Australian football culture as it is our wider culture of racism and masculinity." - The Age, Melbourne
"It's very easy to be labelled an angry black man."
Heritier Lumumba, formerly known as Harry O'Brien, was in the middle of his best season of AFL football when his club president, Eddie McGuire, made an arguably racist comment on-air about an Indigenous player.
As a man of colour and a strong supporter of equality, Lumumba chose to speak out against his high-profile boss. What followed was a media storm and an on-air showdown with McGuire which painted Lumumba as an overly PC, hyper-sensitive villain.
Directed by controversial filmmaker Jeff Daniels, Fair Game recounts how Lumumba's journey to understand his identity as a black man led him to challenge racism and prejudice in sport.
Born to a Brazilian mother and Congolese father, Heritier was the poster boy for diversity in the AFL. He served as the AFL's first Multicultural Ambassador, was appointed a People of Australia Ambassador, spoke at a UN conference on Global Health and was even invited to personally meet with the Dalai Lama.
Joining Collingwood in 2004, Lumumba soon established himself as a footballing force to be reckoned with. He achieved the AFL's coveted All-Australian status and kicked a goal to clinch his club's first Grand Final win in 20 years. But after the tragic suicide of his step-father, the resignation of his mentor and legendary coach, Mick Malthouse, and a falling out with new coach Nathan Buckley, Lumumba began to question who he was, and who he wanted to be.
Through exclusive access to Lumumba, his friends and family, AFL legends Mick Malthouse, former Collingwood Capitan Nick Maxwell and sports journalists, Fair Game uncovers the personal and professional journey of a man who, at the top of his game, dared to hold a mirror to a nation that didn't like what it saw.
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Jamaican Curry Goat
Jamaican Curry Goat
Introduction :
A Caribbean Experience
Ingredients :
3 pounds Goat with bone, cut into 1-inch cubes
1 lime
1 large onion, sliced
6 cloves garlic, finely chopped
2 teaspoons salt
1 teaspoon black pepper
1 teaspoon thyme leaves
1/2 teaspoon finely chopped Scotch bonnet Pepper*
2 tablespoons canola or vegetable oil
1 teaspoon sugar 5 green onions, chopped
2 teaspoons curry powder
2 potatoes, peeled and cut into 1/2-inch cubes
* Note: The Scotch Bonnet ( Habanero) peppers mentioned in the recipe are extremely hot and spicy.
1. Squeeze the lime juice over the goat; let it sit for 10 minutes and then rinse with cold water.
Drain off excess water.
2. Place the goat in a bowl and add the onion, garlic, salt, black pepper, thyme, and Scotch bonnet pepper. Wearing rubber gloves, rub the spices into the goat with your hands. Marinate, cover and refrigerate, for 1 to 2 hours.
3. In a large pot over medium heat, heat the oil .and sugar, stirring until the sugar is brown. Add the goat with marinade, green onions, and curry; stir thoroughly.
4. Cover the pot, reduce the heat to low, and simmer the goat slowly in its own juices, stirring occasionally, until the goat is nearly tender, about 30 minutes. If the meat is tough, pour cup of water.
5. Add the potatoes and – cup, stir thoroughly. Cover and simmer for 15 minutes or until the potatoes are cooked but not too soft. Smash some of the potatoes to thicken the sauce, if desired.
6. Serve with rice or Jamaican roti and a salad.


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