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HaloBOTPosted by mcb1 in Robots with Wheels on Mar 30, 2018 11:44:28 PM
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This robot was a collaboration between my daughter and I.
The idea was she could use flowchart software to program it, however that never really happened.
The design was based on an earlier and slightly larger model I built.
I had assisted the local school in a challenge and felt the 'feelers' that were used for sensing a wall were too delicate and bent if they hit too hard or got caught, so I worked on a bumper system.
Version 1.0 on the left and ver 0.9 HaloBOT on the right.
A second angled plate was fitted and the battery pack velcros to this.
As the drawing shows the shape of the bumper was made to help prevent it getting stuck.
HaloBOT was essentially Ver 2.0 using commonly available parts (board), motors and wheels.
It uses a castor underneath that glides on the surface to act as a nose wheel.
The design was refined by Hayley and once built she added the graphical touch to it.
HaloBOT was the name she gave it.
The design of the front bumper is such that it can detect three different touches, using two switches.
This shows the bumper before the triangle shaped clearance holes were filled.
It also shows a chip in the corner which was 'removed' by some rounding.
Pressure on the left side operates the left bumper switch. Pressure on the right side operates the right bumper switch.
However pressure directly onto the front of the bumper will operate both switches.
This is achieved by making the mounting mount float (the screws are have a lock nut on the bottom), and the 45 deg angle surface the micro-switches connect with.
The spring action inside the micro-switch provides the necessary centering action without any additional springs.
The use of acrylic also means it is non marking (or hard to isolate what caused those marks), and the shape means it can push it's way past if you get the programming wrong.
You should be able to enlarge this using the measurments as a guide, and print full size to use as a template.
Stick it down onto ypur material of choice, and cut out.
Tamiya provided the wheels, and I discovered that these are one of the 'stickiest' off the shelf, meaning it has the best traction if your motors are up to it.
The Tamiya gearbox allows for multiple ratios and is cheap and robust, although not very good in dirty situations due to it's open construction.
Updated My software code included this note ...... Tamiya Dual Gearbox at 114.7:1 ratio (Type C) and 56mm wheels
The gearbox configuration changes depending on which ratio you choose, so multiple mounting holes were provided, however we've never changed it.
The gearboxes are easy to mount and together with the wheels make a very simple construction.
The power consumption is very light, and therefore the battery voltage remains constant which makes programming easier.
Some other bots have high speed and high discharge, so 0.25 secs motor at the start makes the bot travel much further than 0.25 secs after some time in use.
These have no encoders so there is no correlation with time v distance travelled.
The chassis of any robot is the backbone.
Because these tend to be a WIP (Work In Progress) you need to allow room for extras to be added, and mounting can be a problem.
The chassis was constructed using 5mm aluminium that was recycled (previous life was a blank panel in a rack) and most holes are drilled and tapped for M3. (use meths as the lubricant for the tap)
The intention was to enable it to be made using basic hand tools.
I've seen the odd robot using a very lightweight chassis which can flex and bend, or becomes too hard to add extras, so while this could be considered as over engineered, in this case it wasn't going to be the fastest or lightest bot.
The board is based on Picaxe 18 and was programmed in Basic.
The Picaxe software can be programmed using a flowchart, which removes the need to understand Basic.
It does provide an early and easier learning curve, which was the reason it was chosen (at the time).
HaloBOT is programmed to wait after it is turned on, wait for a bumper switch to operate, then move forward until it detects a wall.
It will respond until it detects a wall and respond accordingly with the aim of keeping it moving forward.
Since there is no vision and both motors were travelling forward, the angle of collision is not known, hence there are two options when it touches a wall :-
- stop the motor on that side and reverse the other motor, then move both motors forward.
- Stop both motors and reverse both, then make the motor on the side that touched go forward first, followed by the other motor.
As you can see there is a difference in the amount the bot clears the wall by, and how quickly forward progress is made.
Any time you reverse, you will lose time and distance travelled.
The next problem was being stuck in a corner.
The worst is striking the corner at 45 degs where you react to one side touching followed by the same reaction on the other side, and it repeats.
In this case we counted the contacts and then made the next touch add more time to the sequence to break the deadlock.
This shows in the video as a 'pause' to show it is thinking about the next move, and it carries on.
We added an IR sensor to the front in order to warn of impending wall and slow it down.
It was never programmed to be used, but means there is some protection from collision with objects.
You can detect the bumper switches at turn on, and jump to a sub routine in the software to do one of three operations.
One of these routines was to provide a method of equalizing the motors so it drove straight.
DC brushed motors can be run forward or backwards, and are never the same speed.
Manufacturing tolerances also means one will run slightly faster than another, so it's impossible to make these run straight.
Because the motor can be PWM (Pulse Width Modulated) it does mean you can adjust the speed of the fastest motor to something less than 1.
This gets set in software or is best stored in the EEPROM so it can be set and used.
It was tagged as a future enhancement.
The video show Halobot trying to escape the lid of an A4 Paper box.
It keeps on going and never really understands that it can't escape, but does provide entertainment.
Hopefully someone else will enjoy making something similar.
If you do use my bumper design, it would be nice if you could acknowledge this blog.
Edit 04/04/18 Code added, and Motor details.
This was designed to run on a Picaxe 18 board with the L293D motor controller http://www.picaxe.com/docs/chi035a.pdf
'Robot Test Program For PICAXE18 microcontroller 'using www.rev-ed.co.uk CHI007 'Opposite motor is off during turns 'MCB May 2011 'Suited to HaloBOT 'output pin allocation (%76543210) '76 = Right Motor (viewed from the rear) '54 = Left Motor (viewed from the rear) '3 = not used '2 = LED B 'future '1 = LED A 'future '0 = piezo sounder 'future 'input pin allocation '7 = Right Switch looking from the rear '6 = Left Switch looking from the rear 'counter allocation symbol RightCount = b0 symbol LeftCount = b1 symbol ForwardCount = b2 symbol CornerCount =b3 symbol BackCount =b4 symbol LastTurn = b5 symbol RightBump =pin7 symbol LeftBump = pin6 'start going forwards 'testing switches as you go Waiting: 'In order to put the robot down, the motors should be off 'Press a bumper switch to start if RightBump = 1 or LeftBump = 1 then check goto waiting check: pause 100 main: let pins = %10100000 'both motors forward ForwardCount = ForwardCount + 1 if RightBump =1 or LeftBump =1 then pause 50 'time to settle and check if both touch endif 'if RightBump = 1 and LeftBump =1 then backturn 'if RightBump =1 and CornerCount >3 or LeftBump =1 and CornerCount >3 then Corner if LeftBump = 1 then left if RightBump = 1 then right if ForwardCount = 200 then ResetCount goto main ResetCount: 'sound 0,(255,25) ForwardCount = 0 RightCount = 0 LeftCount =0 CornerCount =0 LastTurn=0 Goto Main left: 'left switch hit 'so stop, both reverse, turn right 'LastTurn =1 If LastTurn =1 then CornerCount = 0 else CornerCount = CornerCount +1 endif LeftCount = LeftCount +1 let pins =%00000000 'Stop let pins =%01010000 'Reverse 'sound 0,(110,25) pause 100 let pins =%00100000 'Left forward, Right off pause 50 LastTurn =1 ForwardCount =0 'If LeftCount = RightCount +3 or RightCount = LeftCount +3 CornerExit goto main right: 'right switch hit 'so stop, both reverse, turn left 'LastTurn =2 If LastTurn =2 then CornerCount = 0 else CornerCount = CornerCount +1 endif RightCount = RightCount +1 let pins =%00000000 'Stop let pins =%01010000 'Reverse 'sound 0,(50,25) pause 100 let pins =%10000000 'Right forward, Left off pause 50 LastTurn =2 ForwardCount =0 goto main backturn: 'both switch hit 'so stop, reverse, turn to one side 'LastTurn =0 'BackTurn = backTurn +1 If RightCount > LeftCount then let pins =%00000000 'Stop let pins =%01010000 'Reverse sound 0,(100,10,110,10,110,10,110,10) pause 150 'larger reverse movement let pins =%10000000 'Right forward, Right off pause 100 else let pins =%00000000 'Stop let pins =%01010000 'Reverse sound 0,(100,10,110,10,110,10,110,10) pause 150 'larger reverse movement let pins =%00100000 'Left forward, Left off pause 100 endif LastTurn =0 ForwardCount =0 'CornerCount =0 goto main Corner: 'we think we've stuck in a corner therefore we need to add something to exit the sequence ' this would show as a high left right backups without much forward. ' the solution is to decide which side has a greater hit rate, and move opposite. ' In this case I have tried to move back a larger amount, along with more turn. sound 0,(255,10,255,10,255,10) pause 100 'pause 500 If RightCount > LeftCount then let pins =%00000000 'Stop let pins =%01010000 'Reverse sound 0,(75,50) pause 200 'larger reverse movement let pins =%10000000 'Right forward, Right off pause 150 else let pins =%00000000 'Stop let pins =%01010000 'Reverse sound 0,(75,50) pause 200 'larger reverse movement let pins =%00100000 'Left forward, Left off pause 150 endif 'If CornerCount >1 then ' CornerCount =CornerCount -1 'endif Cornercount=0 goto main


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Apple shows us an SDK done right
Wow! Today, Apple announced the software development kit for the iPhone (http://developer.apple.com/iphone/program/), and once again they showed us the right way to do things.
The kit itself is the usual fare, giving developers the tools they need to build applications for the iPhone. The special stuff is the support they're offering those developers.
First, they announced the App Store, where developers can sell or give away their wares. Second, they announced venture capital to give developers the funding they need to launch their new apps. The amount of that capital? $100 million!
This is big news, and I'm not alone in wondering why Microsoft has yet to show similar support to the Tablet PC or UMPC form factors. Would the TPC be considered "niche" or "failed" if Microsoft had given it similar support? Would the UMPC still be hunting for a market?
A while back I called on Bill Gates to bankroll our ink-enabling developers (http://sumocat.blogspot.com/2006/05/office-ink-enablers-unite.html), like Josh Einstein and Loren Heiny. I also called on Microsoft for a better OS for small screen devices (http://sumocat.blogspot.com/2007/01/apple-officially-kicks-everyones-ass.html). So far, Apple's answered those calls instead.
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Labels: mobile tech
Apple shows us an SDK done right
posted by Unknown at 3/06/2008 10:12:00 PM

subset: commoncrawl


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St. Michael-Eppan Pinot Grigio 2018
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|St. Michael-Eppan
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In this third special episode we get the behind the scenes look at the production of this series.
Descendants of the Sun Episode 19 "See You Again" (Special Episode 3) Recap
We begin with behind the scenes footage, with facts sprinkled throughout – production took 258 days, record ratings was 33.8%, etc.
Song Joong Ki (Yoo Shi Jin) worked closely with a martial arts director for the fight and action scenes. The martial arts director comments the fight scenes were to be "light and quick". He noted that Joong Ki was able to bring the character of Shi Jin from fantasy character to a realistic and relate-able character. We see behind the scenes footage of the knife fight in episode 1. Joong Ki comments that it is natural playing a soldier as he's only been discharged from the army for 3 months. Cute scene when Joong Ki admits his character loves Dae Young (Jin Goo). Agreeing, Jin Goo states they have a bromance.
Jin Goo's birthday was on the day the filmed the emergency room scenes in episode 1. Joong Ki leads the cast and crew to sing Happy Birthday. He asks Jin Goo what he should say to his superior before receiving the cake. Power of Unity was the correct answer. Joong Ki complements Jin Goo's timing in scenes and his focus.
Joong Ki found the story of soldier and a romance between a doctor and soldier refreshing and different from other dramas. The director, Lee Eung Bok, comments that Joong Ki is not overly masculine which brought a balance to the role an offered appeal to men and women. Song Hye Kyo felt that Joong Ki was the perfect person to play Shi Jin. Joong Ki says that Shi Jin is a cool character. Joong Ki said that writers focused on Shi Jin's patriotism. Originally he thought the series would be a romantic comedy. But with the underlying patriotism for Shi Jin, he focused on this through out his portrayal. Joong Ki notes that in the face off scene with the Arab diplomats he was nervous but he realized he had to relax to deliver. He notes he wanted to take Shi Jin beyond the words on the page. The scene were he mourns killing Mr. Bad was challenging. The director noted Joong Ki's first take was emotional perfection and the one they used. Joong Ki noted that killing Mr. Bad was killing Shi Jin's role model and difficult but necessary because his love for Mo Yeon was trumped his former respect for Mr. Bad. Joong Ki said he was thrilled to work with Hye Kyo. He felt they were both sincere and had mutual respect.
Now we turn to the character of Mo Yeon. Hye Kyo states that Mo Yeon was unusually forward and opinionated. As this was her first time portraying a doctor, it was challenging. Shi Jin comments that Hye Kyo nailed the emotional part of Mo Yeon. In the scene where she grabs her phone from the base broadcast system, the director tells her to only quickly glance at Shi Jin because she doesn't know he is in the room and she's focused on disconnecting her phone. Hye Kyo apologized for acting cutesy at her age. She admitted that getting hyper when Mo Yeon got drunk was natural to her as she does the same when she drinks. Hye Kyo states the scene when she signs the confidentiality agreement after Shi Jin dies was her standout scene emotionally. The director noted that watching Hye Kyo letting her eyes fill with tears was impressive and impactful.
On the to kissing scenes…Joong Ki notes that the director told him to stare intently at Mo Yeon in the scene. He wasn't 100% on board with that but during the taping of the scene, he realized that it was the right thing to do. Lots of laughter on the set when these two were together. Joong Ki had a tough time putting the rubber band in her hair.
Jin Goo said he was a bit jealous of the lead couple's story because they were happy and cute. While they could only be happy in the flashbacks. Kim Ji Won (Yoon Myeong Joo) said they had to portray a heartbreaking love. Their airport scene took time in rehearsals to block correctly. It was hot and noisy at the airfield. Jin Goo wanted Ji Won to feel comfortable with the emotional scene. Jin Goo shares that in the scene where Dae Young hugs Myeong Joo after finding out she was infected with the virus it was late (the sun was rising), everyone was tired, but because all 4 leads were in the scene it upped the emotional moment for Dae Young and Myeong Joo. I found that insightful.
Now the doctor, young doctor, and annoying manager are interviewed. The annoying manager loved being called the nation's trash.
Category 1 – novelty couples.
*Third place – Scenes of snoopy and Mo Yeon. They noted their chemistry was good.
*Second place – Scenes of the commander and Shi Jin.
*First place – scenes of the young doctor's mother and the hospital chairman. The young doctor offers his congrats to his mother. The doctor states he was surprised that the annoying manager lived.
Category 2 – Role reversal favorite scenes.
*Third place – 3 days/night drinking.
*Second place – the package for Dae Young.
*First place – Mo Yeon's camp wide confession.
Category 3 – scene stealers.
*Third place – annoying manager demanding medical treatment at the camp medical center.
*Second place – young doctor working with pregnant mother, getting bite by annoying manager, CPR.
*First place – doctor and nurse scenes.
Cameo by Yoo Ah In. Cameo by Lee Kwang Soo (Running Man). Cameo by Lee Jong Hyuk.
September 2015 Script reading taping. Hye Kyo was positive about the writers Kim Eun Sook and Kim Won Suk. Joong Ki also trusted the script.
They built the set in Korea and it looked like it was in Greece. Fun on the set scenes.
The producers wanted the earthquake as big and fearful as possible within budget. The after scenes were filmed in Korea in a vacant building next to the Urk set. 20 bags of gray dust covered everything. Joong Ki states the iconic poster scene was well written and he was excited to portray it. We see the blocking of the scene. We see the shooting of the scene. We see the final scene. The director notes that as a soldier Shi Jin had different duties than Mo Yeon did as a doctor but the earthquake allowed them to work together creating the melodrama aspect.
The actors endured dust, gravel and tight spaces during filming of the after earthquake scenes.
October 2015 they filmed in Greece but unexpected rain and wind forced many schedule changes and challenges for the production team. Most of the child actors are native and this was their first time acting. We see the blocking for the Shi Jin and Mo Yeon saving the young girl scene. Joong Ki said that was a difficult scene it was hard for all the actors to gell. We hear the high winds during scenes of Shi Jin and Mo Yeon. The director compliments Joong Ki and Hye Kyo for emoting under difficult situations. Joong Ki notes the "should I confess or apologzie line" was brilliant. We see the blocking for the Myeong Joo and Dae Young scene and the final scene. We see the director blocking the kissing scene in the truck with Joong Ki and Hye Kyo. Every detail is defined. Cool, they had a drone film the boat scene. Blocking and filming the final scene on the beach.
Blocking and filming the parking lot scene in episode 14. Joong Ki was injured in the scene. Per the dramafever article "While filming an action scene on November 23 for Descendants of the Sun, Song Joong Ki fell and was injured. At the time, despite having his arm in a cast, his recovery was estimated to be "speedy," according to his agency, Blossom Entertainment. Subsequently, it was reported on November 27 that, upon closer examination at a hospital, doctors determined Song also suffered a damaged ligament to his right knee in addition to the fractures in his arm. The treatment involved physical therapy, and it was estimated that he needed 8 weeks for a full recovery." Joong Ki took 2 weeks off. The director noted that the final showdown with Mr. Bad was filmed after Joong Ki's injury so he was not 100%. He compliments Joong Ki's focus and drive in those scenes. He could hardly walk in those scenes. Joong Ki got a call from Hye Kyo and she told him to relax and recover. Hye Kyo notes that Joong Ki struggled with being injured and unable to perform. She noted in their couple scenes they filmed her scenes first to reduce his set time.
December 2015 final taping. In the restaurant scene. Hugs all around. 258 days of shooting done!
My Thoughts
* This was the last of three special episodes. I enjoyed the behind the scenes look at this series. While I'm watching a drama I'm not thinking about the cadre of people that work to create every scene. This episode brought that home. I didn't realize they recreated Urk in Korea and filmed there first. That makes sense. The bad weather was challenging for the Greece portion of the production. They were expecting mild temps and sunshine but got wind and rain. The best part of the episode was the comments from the lead actors and the director. I would have loved to hear from our writers, but that did not occur. It was obvious that everyone felt this drama offered a unique mix of military and medical, a focus on patriotism and service, a cool leading man, a strong leading woman, and a secondary couple that came into their own. I can only concur!
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | Series


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In the year-long OPTIWIN randomized, head-to-head, clinical trial, the OPTIFAST Program resulted in an average weight loss two-fold higher than a reduced-calorie, food-based diet and lifestyle intervention.
BRIDGEWATER, NJ, November 13, 2018 — Nestlé Health Science today announced the publication of positive results from the OPTIWIN study in Obesity,1 the official peer-reviewed journal of The Obesity Society. OPTIWIN, which represents the largest year-long, randomized, clinical trial of a behavioral weight loss intervention with total meal replacement (TMR) conducted in the U.S., demonstrated significant benefits of the OPTIFAST program on both the magnitude of weight loss and the proportion of patients achieving clinically meaningful weight loss at 26 and 52 weeks. The results of the study add to the impressive body of scientific evidence demonstrating the weight-loss and related health benefits of the OPTIFAST Program.
"Obesity continues to be a significant and growing public health challenge. More than half of Americans could be affected by obesity by 2030 if current trends continue. This is complicated by the fact that trying to lose weight and keep it off is challenging for most. This study shows that the OPTIFAST Program can help with significant and sustained weight loss, even among those who have tried and failed to lose weight in the past," said Dr. Jamy Ard, MD, Professor, Department of Epidemiology and Prevention and the Department of Medicine, Wake Forest University Baptist Medical Center and OPTIFAST Medical Director. "Participants in the OPTIFAST group had an average of 5.5 previous weight loss attempts and reported losing only about 5 pounds with most attempts; with the OPTIFAST Program, these participants achieved an average weight loss that was clinically significant."
The OPTIFAST Program is a medically monitored weight loss program that combines meal replacement with behavioral counseling and personalized support. In the OPTIWIN study, participants were randomized to either the OPTIFAST Program (OP) or a behavioral intervention using a food-based diet (FB). For the first 12-16 weeks of the study, the OP group followed a TMR diet, consuming ≥800 kcal/day as portion-controlled, nutritionally complete meal replacements (shakes, bars and soups). TMR was followed by a gradual reintroduction of food through week 26, then a 6-month weight maintenance phase. Participants in the FB group received a comprehensive diet and lifestyle intervention that included a reduced-calorie (-500 to -750 kcal/day), food-based diet from weeks 1-26. Caloric intake was adjusted to achieve weight maintenance from weeks 27-52. The intervention provided to the comparator group was adapted from the Diabetes Prevention Program2,3 and is considered to be a standard-of-care lifestyle intervention as recommended in the most recent Guideline for the Management of Overweight and Obesity in Adults from the American College of Cardiology, the American Heart Association and The Obesity Society.4
In addition to the respective dietary interventions, both groups in the OPTIWIN study were medically monitored, participated in individual and group behavioral counselling sessions, and received individualized prescriptions for physical activity with a graduated target of 150-180 minutes/week of moderate-to-vigorous exercise. Primary endpoints for the study were weight loss at 26 and 52 weeks, expressed as percentage of baseline weight lost. These endpoints were analyzed using a modified intent-to-treat approach, including all randomized participants who initiated treatment and had at least one follow-up weight measurement (n=273).
Significantly greater weight loss with the OPTIFAST Program, sustained through 52 weeks
At both 26 and 52 weeks, the OP group lost, on average, twice as much of their initial body weight as the FB group:
- At 26 weeks: 12.4% (SE 0.6) vs 6.0% (SE 0.6) of body weight lost (OP vs FB, respectively; p<0.001)
- At 52 weeks: 10.5% (SE 0.6) vs 5.5% (SE 0.6) of body weight lost (OP vs FB, respectively; p<0.001)
Additionally, the proportion of participants who achieved clinically meaningful weight loss (≥5%, ≥10%, and ≥15%) was significantly higher in the OP group. For example:
- At 26 weeks, 55% of the OP group lost at least 10% of their initial body weight vs 23% of the FB group (p<0.001)
- At 52 weeks, 44% of the OP group lost at least 10% of their initial body weight vs 22% of the FB group (p<0.001)
Greater improvements in waist circumference and body composition with the OPTIFAST Program
Participants in the OP group had significantly greater reductions in waist circumference:
- At 26 weeks: -12.0 cm (SD 16.0) vs -7.7 cm (SD 8.3) (OP vs FB, p=0.011)
- At 52 weeks: -11.9 cm (SD 12.1) vs -7.2 cm (SD 9.3) (OP vs FB, p=0.0011)
Participants in the OP group had significantly greater reductions in total amount of body fat lost (measured by DEXA):
- At 26 weeks: -11.3 kg (SD 7.5) vs -4.4 kg (SD 5.9) (OP vs FB, p<0.0001)
- At 52 weeks: -9.7 kg (SD 10.4) vs -3.5 kg (SD 6.6) (OP vs FB, p<0.0001)
No significant difference was observed in discontinuation rates between groups (29.3% OP; 31.9% FB). Main reasons for discontinuation were subject request to no longer participate in the program (11.0% OP; 18.7% FB) or lost to follow-up (11.0% OP; 9.6% FB). 84.5% of the OP group and 68% of the FB group reported at least one adverse event during the year-long trial. The most commonly reported adverse events in the OP group were constipation (18.7%), headache (17.4%), dizziness (16.8%), nasopharyngitis (11.6%), and nausea (11.6%). Serious adverse events were reported by 4.5% (7/155) of the participants in the OPTIFAST group and 3.3% (5/150) in the food-based group; none were assessed by the investigators to be related to treatment.
"The comprehensive OPTIFAST approach combining meal replacement with ongoing medical monitoring and a behavioural intervention, has been proven to support significant weight loss in patients with obesity," noted Dr. Krys Araujo Torres, MD, Head of U.S. Medical Affairs for Nestlé Health Science. "The OPTIWIN study demonstrates this weight loss can be sustained over time and it is an important consideration for individuals looking for weight loss programs that can have a lasting impact on health."
Additional OPTIWIN Results at OBESITYWEEK 2018
Additional results from the OPTIWIN study will be reported at ObesityWeek 2018. Dr. Jamy Ard will present the poster (T-P-3127), titled "OPTIFAST® Increases Weight Loss Response Compared With Food Based Diet Plan: The OPTIWIN Study," on Tuesday, November 13 from 12:00 pm EST to 1:30 pm EST at the Music City Center (Exhibit Hall B-D, Level 3). Dr. Laura Matarese, PhD, RD, will give an oral presentation (T-OR-2018), titled "Effectiveness of OPTIFAST® Compared With Food Based Diet Plan on Body Composition: The OPTIWIN Study," on Tuesday, November 13 at 4:45 pm EST at the Music City Center (Room 201 A-B, Level 2).
About OPTIFAST
The OPTIFAST Program is a non-surgical weight-management option designed for people with a Body Mass Index (BMI) greater than 30. The program, which is available at more than 400 weight loss clinics across the U.S., is a medically-supervised intervention that closely monitors and assesses progress towards better health and emotional well-being. The program utilizes a meal replacement plan that transitions to self-prepared 'everyday' meals, in conjunction with comprehensive patient education and support to help people lose weight, which can in turn reduce weight-related health risks. Clinical supervision is a key component of the program. Patients in the OPTIFAST Program meet regularly with their medical provider for monitoring and counselling.
The OPTIFAST Program was launched in 1976 to fill the growing need to address obesity in a safe and effective way with medical monitoring as a key component. As diseases related to obesity became more prevalent, the OPTIFAST Program was introduced as a sensible option for lifestyle transformation. The OPTIFAST Program is offered by Nestlé Health Science and is available in key markets worldwide. For more information, to see patient stories or to find a weight loss clinic, visit www.optifast.com.
- Ard JD, Lewis KH, Rothberg A, et al. Effectiveness of a total meal replacement program (OPTIFAST® program) on weight loss: results from the OPTIWIN study. Obesity. 2018
- Diabetes Prevention Program Research Group; Knowler WC, Fowler SE, Hamman RF, et al. 10-Year Follow-up of Diabetes Incidence and Weight Loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009; 374: 1677-86.
- Knowler WC, et al. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. N Engl J Med. 2002; 346: 393-403.
- Jensen MD, et al. 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults: a Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol. 2014; 63(25 Pt B): 2985-3023.


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To our concessionaires in NUMANCIA you will experience temporary water supply shut off effectively APRIL 4, 2019 from 8:30AM to 5:00PM.
This is in connection to the Construction and Maintenance Division installing an 8″∅ Pressure Sustaining Valve at MKWD-NWD water transmission line located at the Kalibo Bridge Crossing (Numancia side). The device aims to maximize water flow without jeopardizing the system's pressure. The valve will always be at fully open cock position when the water dynamic head reaches the preset water level.
Relative to this, the supply of water from Kalibo Water District to Numancia Water District will temporarily shut off during the entire duration of the said activity.
Normal operation will resume after completion of the said activity.
For inquiries and other concerns, please call our hotlines at 145 (PANTELCO) and 1620 (CRUZTELCO).


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Events & Seminars
Mayanne Downs Serves on Real Estate Panel
ORLANDO, FL – February 2, 2016 – Attorney Mayanne Downs, shareholder and firmwide chair of GrayRobinson's litigation department, will serve on a panel hosted by the Downtown Orlando Real Estate Forum. The panel will strictly focus on discussing current and developing downtown real estate. In addition to Downs, the other panelists will be Rick Singh, Orange County Property Appraiser, Craig Ustler, Ustler Development Inc. and Arnold Evans, CEO of Central Florida SunTrust. The event will take place on February 18, 2016 at the Church Street Ballroom on Garland Avenue in Orlando. Register to attend the event here.
To contact your closest G|R Office call 800-338-3381
© 2008-2020 GrayRobinson, P.A. All Rights Reserved.


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black market, city council askaris self defense, corridors of justice, kenya, Narobi, Rongai, tomatoes
The events in this post are all factual even though I cannot promise that a little hyperbole will not be applied.
We (ol' man and I) woke up nice and early every Tuesday as we always do. Being harvest day, I was particularly in a good mood, already calculating how much heavier our pockets would be as we returned home later that day.
Let me explain how it all works. The tomatoes we grow, once mature, usually avail a lump sum of fruits every week for harvesting. Sometimes the farm manager does the plucking alone, other times we do it together. On this morning, we were glad to find that he had already done the plucking so all we needed to do was package them in handy plastic bags ready for sale. And that's exactly what we did. A little over an hour and we were done. So we went back to the house and prepared to head to the market.
Now here is where the drama begins. Our 'market' is not really this kind of market.
Let me refer to them as a selection of 'uptown' clients who appreciate our product. Acquintances and old friends of my father. They call him whenever they need the product delivered. Normally we do it in bulk, either on tuesday or Thursday.
To operate in such a set up (the one illustrated above) one needs to fulfill a number of requirements and obtain a of business licence failure to which you shall need to regularly lubricate the pockets of the ever-present city council askaris. Expenses that we were not ready to consider just yet. The little business I learnt in high school taught me that for one to make maximum profits, any activity that involved money leaving the business account destined for someone elses pocket should be the final thing to be dealt with. Besides, the farming project was still taking baby steps so we were waiting it out first to see if all went well before we went legit 😀
So my father and I we arrive in good time; mid-morning just when the post breakfast hunger pangs kick in. The time most employees look for 'mathee wa kuuza food' to sell them chapatis or mandazis to wash down with 11 o'clock tea. Sure enough we found that other vendors had already made way to our 'market' and grabbed the best spots. Some even had the audacity to tell me 'kijana songesha gari huko mbele usitufichie customers'. Since I was sort of new at this,I decided to honor their request. I have in the past heard that it is best if the vendor next to you has your back and you will soon see the reason for this. So I ended up finding a spot where I would not be barricading anyone's potential clientele.
No sooner had I opened the trunk to display the merchandise than customers started trickling in. Of course the usual posers were there, asking kama bei ya nyanya imeshukishwa hadi twenty bob so that they can finally buy. I figured it was too early to start paying attention to these fools. The kikuyu in me was ready to make millions from just this one batch of stock :'-D
It was approximately 10 minutes into my shift when an elderly-looking man walked up to my 'shop'. I noticed that he was awkwardly upset when he did not respond to my cheerful morning salutations. "Unauza nyanya?" This guy asked, completely ignoring the fact that he was really testing my sarcasm! I responded in the affirmative, even going the extra mile, cheerfully informing him of our 'big harvest' discounted price. (I realized that Kenyans respond to anything with the prefix 'discount' or 'sale'.) To which he replied "Eh? Na wapi koti na license?" (Is that so? And so where is your overall and business permit?" I froze! I can't really remember what I mumbled back to him but from the corner of my eye, I saw the one thing I did not want to see- The dreaded city council van that I had on many occasions seen in town nabbing those who broke the city's bylaws.
I looked around to try find my ol' man as he was much better at this deliberation sh*t, but it was too late! To make matters worse, there was a lady, a potential buyer, who was standing next to the city council askari. She raised her voice at him, going on about how the geezer should just let me be and that it was my first time. Hurling a few insults in the process. The so called 'geezer' was not amused by her outburst and since the guy could not arrest her, I was lucky enough to get harassed on her account! As the guy reached out to grab the back of my trousers in the typical city-council-askari-fashion I smacked his hand and shoved him away, but not too hard. "Eh, mbona unanivuruga boss?" I asked! You should have seen the look of surprise he had on his face as his eyeballs almost bulged out of their sockets. " Ala, so kijana unajaribu kunichallenge?" Clearly, he was not impressed by my antics and I suspect by the sturdiness of the shove I gave him, better judgement prevailed and the guy opted to use brains as opposed to brawn. "Kijana usinipotezee wakati. Enda uongee na mkubwa pale!" He pointed at the dreaded city council van ushering me to go speak with the fat-cats sitting at the front. Quickly, I glanced at him and decided that it would be better if I locked the car, in case the guy decides to impound my merchandise as well. I turned away and started the longest walk of my life! I took a deep breath and swallowed hard knowing that I had no story in mind that was going to save my skin! Part 2 coming up soon…


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A beautiful 1930´s Swiss made watch movement set on a Trinity Brass silver plated finding, complete with 925 sterling silver chain. Im always amazed with Swarovski´s new colour schemes, and these "antique pink" stones are no exception. A simply stunning necklace!
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Movement, glitter and sparkle. The Baccarat Restaurant "Le Cristal Room", in the old dining room. Crystal chandeliers and glasses. Designed by Philippe Starck.
Filename: 031222-045_nn.jpg |
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Copyright: Per Karlsson, BKWine Photography
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Robertson (square drive) head wood screws assortment is an ideal kit to have on hand for all your DYI/ Building projects and Repairs.
This assortment pack has a range from 20mm-80mm lengths to cover nearly every application. Head sizes include S0, S1, S2, S3
Packaged in its own heavy-duty storage organizer with adjustable compartments
Includes (head width x overall screw length)
If you have any questions about this product, let us know.


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Body of missing baby found in Oakland canal
OAKLAND He'd been missing, feared dead since crash on Saturday
The body of a 10-month-old baby boy was found in an Oakland canal Thursday afternoon, five days after he was ejected from a pickup truck as it overturned in a flood control channel, authorities said.
The body was found by a volunteer search team about 4:15 p.m. in the waters of a canal near 66th Avenue and the Martin Luther King Jr. Regional Shoreline.
The body was brought on a canoe to shore. Relatives identified the body as that of John Uaisele, said Wade Hess of City Team Ministries, which had deployed a group of volunteers in recovery efforts this week.
The searchers had been looking for John since 7 a.m. and were about to leave for the day when Jose Hernandez, 49, acting on a hunch, decided to comb a spot along the shore. Hernandez said he found John's body just underneath the surface. The baby was clad in a Spider-Man outfit, he said.
"When I think about the family when they came up to the boat, I get a little emotional about it," Hernandez said.
John was believed to have been swept away in the rushing canal waters after the truck was hit by a limousine on Saturday night, officials said.
John's father, Petelo Uaisele, 25, was killed in the crash. The baby's 1-year-old sister and his mother, Mary Uaisele, were also in the truck but escaped serious injury, authorities said.
An Alameda County sheriff's dive team and Oakland firefighters searched the murky waters of the canal in the days after the crash before calling off their efforts. An East Bay Regional Park Police helicopter also surveyed the scene from above.
Hess said his group has spent days searching for John. "The question is, 'What if it was me? What would I want?' " Hess said of the search effort.
The canal channels creek water and rain out to the bay not far from Oakland International Airport. The search was hindered by trash in the water, which was so dirty that visibility was very low, officials said.
The crash occurred at 7:30 p.m. Saturday, when the pickup was traveling north on Hegenberger Road at Hamilton Street. The truck was hit by a limousine, went off the road and flipped onto its roof, police said. It landed in the flood control channel filled with at least a foot of rushing water.
The crash remains under investigation.


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One Vietnamese startup is set to launch a solution that monitors air quality in the workplace or wherever people gather.
Two young men from Vietnam caught the attention of many foreign visitors at IBM's Think 2019 in San Francisco last February with their tMonitor - an indoor air quality monitoring solution.
The tMonitor solution, including both software and hardware, leverages Machine Learning with IoT to monitor and prevent air pollution and improve health conditions, and was named Asia Pacific Champion of IBM Watson Build 2018 at Think.
ThinkLabs, the name behind the tMonitor solution, was the only Vietnamese company on the shortlist as Asia Pacific Champion.
Its Chief Operating Officer Vu Hai Nam and his partner, Chief Technology Officer Tran Duc Nghia, are both proud to have been named Asia Pacific Champion. "We spent many months and long nights finding a solution that worked, and it felt great to receive that validation from IBM," Mr. Nam told VET.
They recalled the hard days since they had the idea of creating a solution that helps people deal with an increasingly polluted environment. They had sleepless nights after learning, coding, and meetings and then more learning, coding, and meetings. But where there's a will there's a way.
ThinkLabs received support from the IBM Global Entrepreneur Program in 2017, giving it access to the global giant's cloud technology and resources to develop their ideas and solutions.
Since 2018, through Mr. Nghia connections with a South Korean partner that is one of the leading hardware companies in the country, they have had opportunities to travel there on study trips, acquiring know-how about hardware development such as how to design a sensor box and how to make a circuit board.
tMonitor is powered by the IBM IoT Platform and IBM Cloud for edge device lifecycle management, a hardened end-to-end security solution that ensures the highest standards of security, reliability, and scalability of the network.
This enables the rapid deployment of devices in any indoor environment regardless of the infrastructure of the building. The solution is an IoT device that delivers real-time, accurate, and precise measurements of particles (PM 1, PM 2.5, and PM 10), gases (VOCs, SO2, CO, O3, CO2, and NH3), and environmental conditions (temperature, humidity, and light).
ThinkLABs then took the tMonitor solution to IBM Watson Build 2018. In every phase and round, the solution was technically proven by IBM experts, and Mr. Nam and his partner presented a 20-minute pitch. "Every partner in Watson Build is positioning its business to capture AI opportunities that are growing by the day," said Ms. Catherine Solazzo, Vice President, IBM Partner Ecosystem Marketing. "Naming this year's global champion is not going to be easy. Each finalist has brought forward strong solutions."
Developing tMonitor as an automated and continuous workplace environment monitoring system with consistent implementation costs and accurate results of working conditions at agencies, enterprises, and areas with a high concentration of workers, Mr. Nam and Mr. Nghia hope to minimize risks to humans and losses both materially and physically when a crisis occurs in a workplace.
"We previously used people as a tool to detect incidents, but there were cases where there was no direct human presence or were incidents that could not be detected," Mr. Nam said. "So we researched and developed the use of sensor networks. Lately we have noticed that it is possible to increase workplace productivity and protect people by improving air quality."
Developing 'Make in Vietnam - Made by Vietnamese' products
Despite being a startup, ThinkLabs has had access to new IBM technologies such as IBM Cloud, IBM Watson IoT Platform, and IBM Watson Machine Learning to develop its solutions and equipment.
"With a responsibility and desire to promote creative development globally, IBM will always be ready to support and develop startups like ThinkLabs, giving them more opportunities to access, experience, and use IBM's new technologies for practical and wide application," said IBM Vietnam's Chief Technology Officer Le Nhan Tam.
"We hope that ThinkLabs' products will continue to develop and provide value to both businesses and the community."
After much research and development, ThinkLabs is now completing the final phase of testing the stability of its equipment, before officially developing commercial products in factories, apartment buildings, hospitals, and shopping centers in August.
"To ensure the best quality of tMonitor, we purchased specific high-end sensors from abroad to assemble complete boxes, as well as improve the software performance on AI and Cloud systems," Mr. Nam said. ThinkLabs has now set up tMonitor at 18 test installation locations.
Together with being named Asia Pacific Champion at Think 2019, the company also received a Sao Khue Award 2019 from the Vietnam Software Association (VINASA); the most prestigious honor in Vietnam's IT and software industry.
"These two prestigious awards have helped ThinkLABS affirm our position and the position of our tMonitor products," said Mr. Nam.
"This also motivates us to continue developing 'Make in Vietnam' products and pursue our mission of building resilient and sustainable enterprises by creating a healthier and safer indoor workplace for everyone. Good air quality improves productivity."
ThinkLabs will call for more investors to supplement its capital and produce more equipment, expand scale, and improve product quality, using AI technology to take tMonitor to the world. VN Economic Times
Linh San


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Associate Professor Ingrid Winkler is a National Health and Medical Research Council (NHMRC), is a Senior Research Fellow at Mater Research and leads the Stem Cells and Cancer Research Group at Mater with a team of seven researchers (four staff and three PhD students).Ingrid's research seeks to understand how normal and malignant haematopoietic stem cells are regulated by their local microenvironments (niches). This innovative research has already led to several discoveries, such as a novel strategy to protect haematopoietic stem cells from chemotherapy or radiation damage. This work could alleviate potentially life-threatening side-effects of cancer therapies and also lead to new complementary strategies to improve how well cancer therapies work. Ingrid's basic research has been recognised as among 'Ten of the best research projects in Australia' by NHMRC (2013) and has contributed to Phase I/II clinical trials to help patient outcomes. Over the last 10 years Ingrid has attracted more than $5 million in competitive national and international research funding to Mater, has generated five patents on new strategies to alleviate disease and published over 30 scientific publications.Ingrid is also passionate about training the next generation of leaders and leads our highly successful mentorship program at Mater. In other leadership roles Ingrid also sits on the Translational Research Institute (TRI) Mentorship and Leadership Group, TRI Caucus, Gender Equity Committee and Biosafety Committee at the University of Queensland."I undertook a career in medical research because it combines my passion for solving puzzles with helping others. I love this about Mater Research. Part of this drive comes from my experience whilst travelling the world where I worked with patients in a small hospital in Barvaria, Germany. It was there I realised I needed to do more to help these patients and followed the path to research. It is now wonderful to know this passion for seeking to understand how the body works has now led to discoveries already helping to save lives."
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Skeletal metastases present a major clinical challenge for prostate cancer patient care, inflicting distinctive mixed osteoblastic and osteolytic lesions that cause morbidity and refractory skeletal complications. Macrophages are abundant in bone and bone marrow and can influence both osteoblast and osteoclast function in physiology and pathology. Herein we examined the role of macrophages in prostate cancer bone lesions, particularly the osteoblastic response. First, macrophage and lymphocyte distributions were qualitatively assessed in patient's prostate cancer skeletal lesions by immunohistochemistry. Second, macrophage functional contributions to prostate tumour growth in bone were explored using an immune-competent mouse model combined with two independent approaches to achieve in vivo macrophage depletion: liposome encapsulated clodronate that depletes phagocytic cells (including macrophages and osteoclasts); and targeted depletion of CD169+ macrophages using a suicide gene knock-in model. Immunohistochemistry and histomorphometric analysis were performed to quantitatively assess cancer-induced bone changes. In human bone metastasis specimens, CD68+ macrophages were consistently located within the tumour mass and at the tumour/bone marrow margins. Osteal macrophages (osteomacs) were associated with pathological woven bone within the metastatic lesions. In contrast, lymphocytes were inconsistently present in prostate cancer skeletal lesions and when detected had varied distributions. In the immune-competent mouse model, CD169+ macrophage ablation significantly inhibited prostate cancer-induced woven bone formation suggesting that CD169+ macrophages within pathological woven bone are integral to tumour-induced bone formation. In contrast pan-phagocytic, but not targeted CD169+ macrophage depletion resulted in increased tumour mass, indicating that CD169neg macrophage subset(s) and/or osteoclasts influenced tumour growth. In summary, these observations indicate a prominent role for macrophages in prostate cancer bone metastasis that may be therapeutically targetable to reduce the negative skeletal impacts of this malignancy, including tumour-induced bone modelling.
Hematopoietic stem cells (HSC) reside in perivascular regions of the bone marrow (BM) embedded within a complex regulatory unit called the niche. Cellular components of HSC niches include vascular endothelial cells, mesenchymal stromal progenitor cells and a variety of mature hematopoietic cells such as macrophages, neutrophils, and megakaryocytes—further regulated by sympathetic nerves and complement components as described in this review. Three decades ago the discovery that cytokines induce a large number of HSC to mobilize from the BM into the blood where they are easily harvested, revolutionised the field of HSC transplantation—curative for immune-deficiencies and some malignancies. However, despite now routine use of granulocyte-colony stimulating factor (G-CSF) to mobilise HSC for transplant, only in last 15 years has research on the mechanisms behind why and how HSC can be induced to move into the blood began. These studies have revealed the complexity of the niche that retains HSC in the BM. This review describes how BM niches and HSC themselves change during administration of G-CSF—or in the recovery phase of chemotherapy—to facilitate movement of HSC into the blood, and research now leading to development of novel therapeutics to further boost HSC mobilization and transplant success.
• Daily administration of Flt3 ligand in mice depletes erythroblastic island macrophages and inhibits erythropoiesis in the bone marrow.• Suppression of medullary erythropoiesis is compensated by increases in erythroblastic island macrophage numbers and erythropoiesis in the spleen.• The suppressive effect of Flt3 ligand on medullary erythroblastic island macrophages and erythropoiesis is likely to be indirect, as Flt3 receptor is not expressed by macrophages or erythroid progenitors.
Harvest of granulocyte colony-stimulating factor (G-CSF)-mobilized hematopoietic stem cells (HSCs) begins at day 5 of G-CSF administration, when most donors have achieved maximal mobilization. This is based on surrogate markers for HSC mobilization, such as CD34+ cells and colony-forming activity in blood. However, CD34+ cells or colony-forming units in culture (CFU-C) are heterogeneous cell populations with hugely divergent long-term repopulation potential on transplantation. HSC behavior is influenced by the vascular bed in the vicinity of which they reside. We hypothesized that G-CSF may mobilize sequentially cells proximal and more distal to bone marrow venous sinuses where HSCs enter the blood. We addressed this question with functional serial transplantation assays using blood and bone marrow after specific time points of G-CSF treatment in mice. We found that in mice, blood collected after only 48 hours of G-CSF administration was as enriched in serially reconstituting HSCs as blood collected at 5 days of G-CSF treatment. Similarly, mobilized Lin−CD34+ cells were relatively enriched in more primitive Lin−CD34+CD38− cells at day 2 of G-CSF treatment compared with later points in half of human donors tested (n = 6). This suggests that in both humans and mice, hematopoietic progenitor and stem cells do not mobilize uniformly according to their maturation stage, with most potent HSCs mobilizing as early as day 2 of G-CSF.
For decades it has been assumed that lethal irradiation in bone marrow transplantation experiments ablates the entire host hematopoietic system but preserves the host non-hematopoietic bone marrow stroma. This postulate is at the basis of transplantation chimera experiments in mice to test involvement of hematopoietic cells versus non-hematopoietic stroma. As BM-Macs support HSC niche homeostasis, we examined whether host-derived BM-Macs persist lethal irradiation and play a role in HSC engraftment. Recipient MacGreen mice (expressing GFP in myeloid cells under the control of Csf1r promoter) were lethally irradiated (11.5Gy) and transplanted with sorted syngeneic B6.SJL CD45.1+ Lin-Kit+Sca1+ sorted cells. Flow cytometry analyses of BM 2-30 weeks (wk) post-transplant confirmed more than 99% donor chimerism of monocytes and granulocytes validating ablation of recipient HSC. In contrast, GFP+CD11b+F4/80+CD169+VCAM-1+ERHR3+Ly6Gneg recipient BM-Macs were detected throughout the time-course. A 5.9 fold expansion of these recipient BM-Macs occurred between wk 2 and 5 ( from 45,000 to 270,000 cells/femur) post-transplant which coincided with increased number of phenotypic donor HSC (GFP-Lin-Kit+Sca1+CD48-CD150+). Host BM-Mac proliferation was cell autonomous in the absence of host HSC and granulocytes. Recipient Macs in spleen displayed different frequency and longevity kinetics that correlated with transient post-Tx splenic extramedullary haematopoiesis. In situ, GFP+F480+ recipient BM-Macs were enriched in perivascular microenvironments within both central BM and endosteal regions. These GFP+ host-derived macrophages persisted long-term forming 8.4% of BM macrophages 7months post-transplant. To evaluate the importance of these host-derived radiation-resistant macrophages, we selectively depleted recipient BM-Macs using CD169-DTR mice transplanted with syngeneic ubiquitous GFP+ HSC. Depletion of recipient CD169+ Macs abated engraftment of donor phenotypic HSC by 70% at 5 wk post-transplant and reduced BM reconstitution potential in competitive secondary transplants. In conclusion BM contains a myeloablation-resistant self-repopulating Mac subset that is necessary for efficient and/or sustained HSC BM engraftment following transplantation. Therefore interpretation of transplantation chimera experiments must take into account the persistence of this subset of host macrophages that support donor HSC engraftment.
Many patients with hematological neoplasms fail to mobilize sufficient numbers of hematopoietic stem cells (HSCs) in response to granulocyte colony-stimulating factor (G-CSF) precluding subsequent autologous HSC transplantation. Plerixafor, a specific antagonist of the chemokine receptor CXCR4, can rescue some but not all patients who failed to mobilize with G-CSF alone. These refractory poor mobilizers cannot currently benefit from autologous transplantation. To discover alternative targetable pathways to enhance HSC mobilization, we studied the role of hypoxia-inducible factor-1α (HIF-1α) and the effect of HIF-1α pharmacological stabilization on HSC mobilization in mice. We demonstrate in mice with HSC-specific conditional deletion of the Hif1a gene that the oxygen-labile transcription factor HIF-1α is essential for HSC mobilization in response to G-CSF and Plerixafor. Conversely, pharmacological stabilization of HIF-1α with the 4-prolyl hydroxylase inhibitor FG-4497 synergizes with G-CSF and Plerixafor increasing mobilization of reconstituting HSCs 20-fold compared with G-CSF plus Plerixafor, currently the most potent mobilizing combination used in the clinic.
Hypoxia-inducible factor (HIF)-1α accumulation promotes hematopoietic stem cells' quiescence and is necessary to maintain their self-renewal. However, the role of HIF-2α in hematopoietic cells is less clear. We investigated the role of HIF-2α in leukemia and lymphoma cells. HIF-2α expression was high in subsets of human and mouse leukemia and lymphoma cells, whereas it was low in normal bone marrow leukocytes. To investigate the role of HIF-2α, we transduced human HIF-2α cDNA in mouse syngeneic models of myeloid preleukemia and a transgenic model of B lymphoma. Ectopic expression of HIF-2α accelerated leukemia cell proliferation in vitro. Mice transplanted with cells transduced with HIF-2α died significantly faster of leukemia or B lymphoma than control mice transplanted with empty vector-transduced cells. Conversely, HIF-2α knockdown in human myeloid leukemia HL60 cells decreased proliferation in vitro and significantly prolonged animal survival following transplantation. In human acute myeloid leukemia (AML), HIF-2α mRNA was significantly elevated in several subsets such as the t(15;17), inv(16), complex karyotype and favorable cytogenetic groups. However, patients with high HIF-2α expression had a trend to higher disease-free survival in univariate analysis. The different effects of HIF-2α overexpression in mouse models of leukemia and human AML illustrates the complexity of this mutliclonal disease.


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Festivals & Events:
The Language of Watercolor with Diane Meyer | Friday-Sunday | February 8 – 10
Professional artist, art educator and psychologist Diane Meyer will help students translate their own internal narratives into creative works of art. Using the medium of watercolor, students will explore the how to create movement, delicacy and boldness in their pieces. Using techniques for moving water and pigment across paper or canvas, students will learn how to use their creative practice as a way of personal exploration, while also building new watercolor skills.


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Daniel Boone National Forest
Contact Information
Cumberland Ranger District
2375 KY 801 South
Morehead, KY 40351
Gladie Visitor Center
3451 Sky Bridge Road
Stanton, KY 40380
London Ranger District
761 S. Laurel Road
London, KY 40744
Stearns Ranger District
3320 US 27 North
Whitley City, KY 42653
Redbird Ranger District
91 Peabody Road
Big Creek, KY 40914
Daniel Boone National Forest
1700 Bypass Road
Winchester, KY 40391
The office in Winchester, KY is an administration office located outside the forest.
Contact Us
Swift Camp Creek Trail #219 winds through the Clifty Wilderness underneath large hemlocks with dense rhododendron thickets. The trail crosses several tributary streams and weaves around numerous boulders. While this trail follows Swift Camp Creek for most of its length, it provides easy access to the creek in only a few areas. The trail skirts steep drop-offs that provide views of the creek below.
Make this page look nicer by submitting photos of your hike on Swift Camp Creek Trail #219. Learn more...
Trailheads: Rock Bridge Trailhead - Accessing the trail from here requires hiking a portion of Rock Bridge Trail.
Latitude 37.77089711 Longitude -83.56678467
Angel Windows Trailhead
Latitude 37.798931 Longitude -83.59138607
Trail Connections:
Rock Bridge Trail # 207 (1.25 miles)
Wildcat Trail #228 (1.75 miles)
This trail does not meet accessibility standards for persons with disabilities.
From Slade, take KY 15 for 7 miles to KY 715. Turn left on 715 and continue 0.3 miles to Rock Bridge Road on the right. Follow this road to its terminus at the Rock Bridge Picnic Area. Hike Rock Bridge Trail to its junction with the Swift Camp Creek Trail.
From Pine Ridge (exit 40 off Mountain Parkway), head west on KY 15 to KY 715. Turn right on 715 and continue 0.3 miles to Rock Bridge Road on the right. Follow this road to its terminus at the Rock Bridge Picnic Area. Hike Rock Bridge Trail to its junction with the Swift Camp Creek Trail.
You can also access the Swift Camp Creek Trail near the Angel Windows parking area, which is approximately 5 miles further on KY 715.
Parking is available at the Angel Windows or Rock Bridge trailheads.
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Wildcats Basketball supports teams in all age groups from U11's to U20's and Senior Teams as a part of the Ballarat Basketball Association
The Ballarat Wildcats participate in the Ballarat Basketball Association, we have teams in almost every age group and level in the competition.
We have our own training facility on the Ray Borner Court at the Eastwood Leisure Complex, Eastwood St Ballarat.
Our facility include a fitness room and seperate meeting room.
Fees Structure:
Club Registration fees for Summer 2014 Season
One child registration - $60.00
Two children Registration - $100.00
Three or more Registration - $120.00
Top deposit - $50.00 Shorts - $50.00
Hoodies - $55.00
NEW!!! Training Tops - $45.00
|Telephone Number:
|03 5332 9695


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Can I Get a Car Title Loan in Missouri?
If a resident of Missouri is looking for quick and easy funding, they may be thinking about getting a car title loan. Car title loans work by using a vehicle as collateral so that borrowers may receive emergency funding. Unfortunately, car title loans are not available in every state across the country—but they are available in Missouri. Here is more information on car title loans, and how you may be able to obtain one in Missouri.
What Documents Does Missouri Require to Get a Car Title Loan?
To obtain a car title loan from LoanMart in Missouri, along with a qualifying vehicle, a potential borrower will need the following documents/pieces of information1:
- A government-issued photo ID (such as a state I.D. or driver's license)
- Proof of income
- Car title in your name
- Some type of vehicle inspection
Once a lender has this information they will then inspect the car to determine each individual's eligibility for a car title loan.
Can I Get a Car Title Loan in Missouri If I Have Poor Credit or Past-Bankruptcy?
The great thing about car title loan eligibility with LoanMart is that unlike a lot of major lending options, a potential borrower's credit history isn't as important. Some car title loan lenders don't even need to check a borrower's credit history at all. This is because the lender has the security of the borrower's vehicle. Instead, here is what LoanMart will look at:
· The Value of the Vehicle
LoanMart will look at the make, model, year, and condition of the car to then come up with a value for the car. The value of the car will play a large role in determining the value of the loan.
· The Borrower's Income
LoanMart will also largely consider the monthly and annual income of their borrower. This will help them figure out what value of a loan makes sense for their borrower's unique financial situation.
· The Borrower's Ability to Pay Back the Loan
Before determining eligibility, LoanMart will work with the borrower's income, and the loan terms to figure out if they have a reasonable ability to pay back the loan that they are signing up for.
How Car Title Loans Work In Missouri?
When it comes to the lending industry, each state gets to determine how they regulate title loans. If a state does allow these kinds of loans, there are a few terms they regulate, like: the interest, the length of the loan, etc. In addition to this, because title loans have the unique variable of repossession involved, it may be helpful to know that each state also has variations on that process.
· Repossession Laws in Missouri
Once a loan hits the default point, a lender in Missouri has the right to repossess the vehicle involved. However, they must give their borrower a notice. During this time, the lender will offer their borrower options for continuing the loan's contract. Once the specified period is up and the borrower and lender cannot agree on payment arrangements, then the lender may repossesses the car.
Title loans are available in Missouri, and many lenders are available to help. Before looking into obtaining a title loan, understand the necessary information that lenders will ask for, as well as the factors that impact a person's eligibility for a car title loan in Missouri.
Every state has their own rules and regulations when it comes to the lending industry, Missouri included. By knowing these rules and the ins-and outs of the process, a borrower could make sure they get the most from their car title loan experience.


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The Organica BlueHouse is a packaged plant solution, which is a custom-engineered and pre-fabricated facility that captures all the benefits of Organica-powered wastewater treatment and reuse in one easy-to-install package. This not only accelerates the design and construction process, but it also makes it easy for you to choose the design that best integrates with your environment. Like all Organica facilities, it is compact, odourless and energy efficient, all while providing a unique, botanical garden-like look and feel that maximizes flexibility in potential locations and minimizes negative impact on the surrounding land. As a result, The Organica BlueHouse is an ideal choice for sustainable wastewater treatment and reclamation, good for applications up to 400 m3/d (105,000 gal/d).
Organica BlueHouse is a perfect solution for smaller-size applications, including small communities, real estate development projects, hotels or resorts.
Use our WWTP Design Generator to plan and compare multiple wastewater treatment plant options in 3 easy steps


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Calendar can be a system to list an interval (such as the example). These types of names are calendar dates. This date might be depending on the actions of heavenly bodies like the sun and moon. Calendars may make reference to tools that illustrate the machine.
And also on this occasion we are going to talk about about telugu calendar 2018 july and august ideally everything we give below is helpful for a person.


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About the Zwinger vom Heidelberger Schloss
Zwinger vom Heidelberger Schloss is a 7 acre facility located in Northern California. It is a kennel owned by Thomas Sauerhoefer, a German Shepherd Breeder with over three decades of experience breeding, training and showing German Shepherd Dogs in both Germany and the United States. The German Dog Training Center is also the home training field for the Marysville Schutzhund Club, a very active GSDCA WDA club. The Marysville Schutzhund Club hosts an average of 3 Schutzhund trials a year, in addition to participating in community events and sponsoring AKC events like Canine Good Citizen testing. The club participates in events throughout the Northern California area, including Marysville, Yuba City, Grass Valley, Sacramento and San Francisco. Members come from all over Northern California to train at the facility.
Credit card payments are now being accepted. If you have any questions about making a payment, please give us a call at (530) 749-8861 or send an email to Thomas Sauerhöefer.
The German Dog Training Center is located in Northern California and we are proud to be the premier suppliers of quality German Shepherd Dogs for families, family protection, personal and executive protection, sport dogs, Schutzhund dogs and police and other law enforcement agencies. We are centrally located and a quick drive for those located in the Bay Area, San Francisco, San Jose, Redding, Sacramento, Grass Valley, Marysville, Yuba City, Ukiah, Sonoma and other Northern California towns. For those in Southern California cities like Los Angeles, Santa Barbara, San Diego and Riverside, we can either arrange shipping or your new companion can be picked up at our facility with a slightly longer drive. For those out of state, we can arrange shipping or you can arrange to come to the facility to pick up your new pet.
Message from Thomas
My name is Thomas Sauerhoefer. I am a breeder of German Shepherds since 1980 in Germany. I am the President and founder of the Marysville Schutzhund Club, and a member of the SV in Germany, United Schutzhund Clubs of America, and the GSDCA-WDA.
I came to America over ten years ago from Germany. My goals are to help people obtain higher quality dogs through my breeding program and importing services and to offer the highest quality dogs for Schutzhund, show, family, and companion. I grew up with dogs all my life. When I was 10 our family got a wonderful boxer, and when I turned 16 we got a Rottweiler named Arko. A close friend of the family took him for schutzhund training because we needed a protection dog for our company. My interest and fascination with the sport of schutzhund took off. At age 18, I bought my first dog, a German Shepherd. I had fallen in love with the breed for their looks and intelligence.
I started my career in Schutzhund and Marysville dog training with Vasko, a German Shepherd with working bloodlines. I titled Vasko to a SchH 3 in only one year and then I bought a female named Banja and titled her to a SchH 3 too. After I got her titles and breed survey, I bred Banja to Vasko and had my first litter of pups. I kept a male pup from this breeding and named him Kim. I trained Kim to a SchH 3. I bred three more litters with Banja, always with good results.
One of the best training helpers in Germany was a member of my club and saw my love for the sport and talent for training dogs. He taught me everything about Schutzhund helper work. By the time I was 24, I started training dogs for other people, both working and show lines, because they also saw my talent for training. Now I do Sacramento dog training and breeding.


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Womans Institute held at Perranporth Memorial Hall meet every Monday, Tuesday and Thursdays.
For more information please call 01872571073.
13 Oct 2018 to 24 Feb 2019
Eden's glittering ice rink is back and it's had a makeover. Why not ave a whirl in our winter wonderland - everyone is welcome, from complete novices to figure skating pros.
Go along and look at the Christmas tree festival at St Pirans Church - beautifully decorated Christmas trees for all to enjoy, open throughout the day at St Piran's church.
Every Thursday at the Seiners Arms with the chance to win £20 food and drink voucher


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The results of load combinations are presented in a window with a set of tables where the most interesting values of each scenario are grouped. This window can be resized with the mouse if needed. In this window, we see a series of buttons whose use is obvious: Exit, to leave this window HTML, to display the table in your web browser, HTML format (format and colors) Export Excel (CSV), to export …Read More
Tag Archives: load combinations
Safety Factors and Combinations
The WinTess software checks if a structure properly supports the loads applied using the "Ratio" concept. The ratio is a numerical value indicating how close we are or exceed load carrying capacity considering the safety factor of any part of the structure. The value "1" is the maximum limit. If we exceed this value, we understand that part of the structure is undersized. If the value is very small, for …Read More


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"Affiliate" revenue / websites have undergone numerous iterations to help keep pace using the rapid evolution from the "web".
What was once an easy "content" website, now must include aspects of branding to guarantee people can attribute its underlying value having a SOCIAL following.
Actually, "SOCIAL" has truly altered the sport with regards to the web. N't i longer is effective be an anonymous avatar hiding behind a nondescript username – you actually need skin-in-the-game which basically means making use of your own name/face to advertise the minds you place forward together with your sites. The relationships received through this method is how the worth lies.
Clearly, making use of your own name opens you as much as competitors… however the trick now's to make sure that individuals have Much more of grounds to apply your content/services than anybody else's. This originates from either posting TRULY sublime stuff, or concentrating on creating as SCINTILLATING service as possible. The second (service) is how "cost comparison" affiliate sites are available in.
Internet Affiliate Marketing = 110% Give, 1% Receive
To completely appreciate the salt water evaporates, you must know that to be able to "earn" money, there's two what exactly you need:
Audience - group who're positively involved in a task (HINT: Many people will happily "try" something totally new whether it inspires them)
Product - something stated people could be prepared to BUY (HINT: NEVER be worried about the merchandise. The merchandise will "sell" itself whether it's good)
The way in which "affiliate" marketing works is to will "recommend" an item for an audience and when them get it – you'll get a cut from the profits.
The issue with internet affiliate marketing is it has bred a lot of "skim" marketers that do not really "do" anything except hype in the next FAD product (weight loss supplementsOrreside chat/gambling/betting etc) and try everything they are able to to obtain people to register.
The problem with this particular is the fact that although it "works", it isn't sustainable within the lengthy term, leaving lots of people HATING the hyperbolic tactics accustomed to trick them into buying things they did not need.
The way to guarantee a sustainable / lucrative "affiliate" marketing earnings is to pay attention to Quitting front. Yes, it's cliché and lots of would argue – relatively ineffective – however it has ONE underlying benefit — builds a crowd. This audience (and also the depth of their relationship) is how growth really comes to have an online "business".
The amount where you are in a position to provide insight, solutions or underlying benefits to particular audience is when much they'll reward you with revenue. The only method to do that would be to forget yourself and identify a "service" by which you are able to look for the
Affiliate Cost COMPARISON Sites
The most crucial factor to think about regard to how "affiliate" sites jobs are there are pretty-much 3 kinds of site you may create (each different in difficulty):
Content Sites (pure content sites centered on supplying specific articles to resolve problems for those who might be looking through Google etc)
Community Sites (blogs etc - typically centered on provision of lifestyle-centric solutions // content, connectivity, etc)
Product Sites (focused either around the reviewing of merchandise, discussion of merchandise or dissection of merchandiseOrbusiness news)
Now, the important thing to all this would be that the effectiveness of each one of the above is usually measured because when deep your relationship becomes using the readers/buyer. This is actually the secret component where "SOCIAL" is available in.
When it comes to why this will be significant – it is important to understand when you are searching to begin generating revenue online, among the Most effective to carry out it's to cope with items that are ALREADY selling. This was once made by creating "review" websites and looking to get them rated on the internet.
Although this labored, the large problem was that 1) the websites themselves were very "THIN" (didn't have real resonance) 2) relied on one supply of traffic (mostly Google).
With no MASSIVE draw of Google, nearly all "review" sites would not receive traffic. People used them simply because they didn't have alternative choice… however with the "social" web (Trustpilot / Yelp / Twitter / Facebook / YouTube), most people are in possession of an option regarding where to find information on products they may decide to buy – and therefore if you wish to "capture" any one of this Countless number of traffic, you have to provide a compelling reason that people really take a look at what you are producing. This is when "cost comparison" affiliate sites are available in.
Cost comparison sites have been in existence for any Lengthy time – have you ever bought insurance, personal finance, property, flights, hotels or many other packages online – you will have likely used websites which basically "tailor" the merchandise leads to the factors you submit. THIS (partially) is exactly what cost comparison functionality is all about — providing people with the chance to discern Which products, prices and suppliers might be best on their behalf.
This functionality lies in the crucible of the items I have been working towards, in regard "affiliate" cost comparison sites…
Putting VENDORS & PRODUCTS First
The "new" affiliate cost comparison model is really quite simple…
Make a website having a CORE concentrate on the best solutions within an industry... after which track the prices from *ALL* vendors
The actual way it works is much like most of the previous "affiliate" systems we have used previously (review sites) – except the main reason for value is you provide the consumer an entire summary of exactly what the "best" goods are for the problem / issue / solution.
You chop the hearsay & speculation (nobody wants to listen to your existence story – they just worry about themselves) – you start growing a "following" through the kind of social networking.
If you do not give a service, or are searching at doing something to generate money quietly – dealing with the PROMOTION of merchandise online is among the best steps you can take. However, to get it done effectively takes Not only setting up someone-sided "review" concerning the options that come with an item which may work. You have to understand the depth that you could imbue in to the service. This is exactly what the brand new "cost comparison" model does.
The "new" cost comparison websites that I have been dealing with yesteryear few years are focused on the supply of merely one SERVICE by which users can experience exactly what they need without getting to trawl through numerous text to have it.
Simply, you provide users having a central "system" by which they are in a position to find out the "best" products inside a market, and find out their historic prices across a lot of vendors. These prices could be gleaned from either native API integrations, or simply from "web scraping" (basically how Google will get all its data). Although this was already done 1,000's of your time before – the issue with MOST "cost comparison" sites is the fact that is they provide.
What we should found was that whenever you combine a highly effective service – the opportunity to really delve deeply into someone's desires & resolve them – having the ability to match their needs against items that really work – you've got a resource that lots of people finish up attempting to use. If you are in a position to blend this with an above average "social" presence, you can be employed in any "market" with authority and gravitas.
Getting While Watching "Right" Traffic
In summary – the Greatest problem for individuals beginning running a business is too little footfall / traffic / throughput.
Although this is not an issue for that "smart" ones who develop a business step-by-step with time, it is a problem for individuals with no real direction (finish up jumping from project to project).
The complete answer to making any kind of "business" work (both offline an internet-based) would be to stand before the "right" traffic.
To get this done, you essentially have to switch the issue on its mind and concentrate on creating "content" that you simply share on a number of platforms (Google / Twitter / Facebook / YouTube etc) by which people can come and go to your "site" to achieve insight around the further steps they are able to take to cope with that which you have/know.
The best way to do that most effectively would be to show you skill around the "social" web (should you "review" products – really walk out the right path to video the outcomes of methods these products work)… after doing that, you have to then create some kind of resource that is so potent that they'll really wish to click on and think about what there are here.
The easiest way with this to become done is to produce a compelling "resource" by which your readers get access to information they'll NEVER get elsewhere. This is accomplished mainly by creating a highly effective service by which people can find out the products and vendors whom they would like to cope with. Should you choose this effectively, you'll earn revenue due to anybody who buys these products that you simply recommend in your site.
Check out this great website for price comparison website.


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Author: Dr Helen firstname.lastname@example.com
My blogsites
- Mainland Discoveries Records of my explorations of landscapes on mainland Australia
- Touching the Tarkine Record of my exploration of Tasmania's Tarkine wilderness
- Walking the Derwent The record of my walk from the mouth to the source of Tasmania's Derwent River
Tag Archives: eucalypt trees
Around the Bluff
Day two of my two hour walk plan. Where to today? I set off, again towards Bellerive Village but this time passing down closer to the waters' edge of Kangaroo Bay. From there I plodded casually around Bellerive Bluff until … Continue reading


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1 Month Anniversary
Thursday, February 23, 2012
1 Month Old
1 Month Anniversary
13 comments:
Happy one month!! (^_^) Your little drawing is super cute, and I'm loving the Sake cup. Thank you for blogging as much as you do, it always cheers me up to see new posts from you!ReplyDelete
Happy anniversary!ReplyDelete
I love your blog! Where do you get your amazing dolls?ReplyDeleteReplies
I generally get my dolls at www.hlj.com when they come up for preorder, because you can get the early bird special price... but you can also order from HobbySearch and get credit for every purchase that can be put towards future purchases!!
They are mostly dolls called Pure Neemo... but there are some Misaki and Barbie thrown in there too sometimes.
Congrats, and what great finds!! I love thrift and antique stores!ReplyDelete
I really hope that you do get better! :)
Happy Anniversary. LOL! You are addicted to Goodwill. You are bound to find good things there. I always do.ReplyDelete
Hello from Spain. congratulations for the first month of your blog. You make very good entries. We remain in contact blog to blog.ReplyDelete
Hello from Spain: congratulations on your anniversary. I really like your blog. keep in touch.ReplyDelete


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We educators have spent much of our time focusing on what children are expected to learn, but how they learn is often less of a focus. Babies are born with "core knowledge" that helps them process the world. When the world doesn't function according to what babies think will happen, they become further engaged and curious to learn more (see "Why Babies Love (And Learn From) Magic Tricks" in NPR Ed).
We know curiosity is a key reason why all humans pursue learning. In our TPA, we look for strategies in learning walks that teachers use to engage students through novelty and variety—the kind of work that engages our learners through their natural curiosity and inquisitiveness. When our students pursue learning through inquiry—your questions, their questions, discussions and projects that engage their minds—we are taking advantage of the natural drive of humans to learn.


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MySQL Database Storage in Cloud Hosting
All cloud hosting accounts acquired through our company are created on our custom cloud website hosting platform where every part of the Internet hosting service has its own cluster of servers. The databases are not an exception and given that we can keep adding additional servers to the cluster that handles them, the space that you can use for your databases is virtually unrestricted. That way, you may grow your websites as much as you would like and run any script which requires MySQL without ever being concerned that you will reach some cap and that your sites won't perform correctly. In addition, you'll be able to freely export and import databases of any size via your Hepsia Internet hosting Control Panel. If you have any questions in this matter, you could ask our 24x7 tech support team to help you with either one of these tasks.
MySQL Database Storage in Semi-dedicated Servers
When you host your Internet sites in a semi-dedicated server account through our company, all of your MySQL-based script applications shall work properly as we do not impose any limits on the size which your databases could have. We have achieved that by using a custom-built cloud platform in which the files, databases and emails run on separate clusters of servers, not on single machines. Thus, the system resources of a particular cluster are literally inexhaustible because we can easily add additional hard disk drives or machines anytime as needed. The Hepsia hosting CP, which comes with all semi-dedicated accounts, will allow you to export and import databases of any size easily. If you use our Internet hosting services, your sites can evolve without limits, allowing you to expand your worldwide web presence and get a lot of new visitors and potential clients.