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Treatment for Low WBC in Aplastic Anemia
Hi all,
I am still fighting my nemesis, low white blood counts, 14+ months post-ATG. Fortunately, my red blood and platelets are holding in quite well, they are almost normal (Hgb 13.2, Plt 135). Unfortunately, my ANC has been trending down since the start of the year, taking a sharp turn for the worse at my CBC yesterday, where it was 560 (it has generally been between 700 and 1000). Yet I feel well (other than some fatigue), and I am not getting sick, even in a flu season for the record books, even surrounded by sick family members and sick people at clinic visits.
Further, my 12 month post-ATG BMB showed great improvement (20 to 30-fold more cellularity than pre-ATG), with a normal distribution of healthy white blood cells in the marrow.
So my crucial dilemma is, what should I do for treatment? I would love to hear from anyone else fighting AA (or another bone marrow failure disorder), who has had a good treatment response in terms of red blood and platelets, but has had to fight chronic neutropenia like I have. Specifically, I have questions in the following areas:
1) ATG - My doctor is considering a second round of ATG, or perhaps another immunosuppressant. I am open to this, but I am wondering if there is any data on outcome for this in my specific case, especially as ATG hits the white blood cells so hard. Has anyone started a course of ATG with their red blood and platelets at very good levels, specifically to deal with their chronic neutropenia?
2) Prophylactic antivirals, antibiotics, antifungals - I've been on 1600 mg/day of the antiviral acyclovir since before I started ATG last year. The plan is to keep me on this at least as long as I'm on cyclosporine, primarily to prevent shingles and related viral issues. Further, if my ANC does not rise, my doctor would like to restart me on a prophylactic antibiotic and antifungal ASAP. If I am not getting sick, I'm not comfortable with this. I fear adverse reactions to being on strong antibiotics and antifungals indefinitely as a prophylactic measure. Had anyone else had experience with taking (or NOT taking) these over a long term while chronically neutropenic?
3) Cyclosporine - My doctor had planned to start tapering me off cyclosporine at 12 months post-ATG, but due to my low ANC he would like to wait another full year to start the taper. I tolerate the cyclo fairly well, but it does give me high blood pressure and elevated creatinine (baseline 0.8, currently about 1.3), and my understanding from the latest NIH studies is that long term full-dose cyclo after ATG response had become controversial. Further, I wonder if there is any chance that the Cyclosporine (or for that matter the acyclovir, or my anti-blood pressure med amlodipine) could be contributing to my low ANC?
4) Neupogen - I was on regular neupogen for the first 8 months post-ATG - 1 to 3 times a week. My ANC responded well and quickly, but of course fell just as quickly. My order at the clinic is for neupogen anytime my ANC is below 750. But I have been refusing it lately. My doctor is OK with that, but wants to give it to me again if my ANC falls below 500. My concern is that my online research suggests neupogen is not indicated for SAA patients as a long term treatment. Has anyone else with SAA been kept on neupogen for several months or more to deal with chronic neutropenia?
...In short, at this point I wonder if any of the medications I am on contribute to my low white blood count. As such, a big part of me wants to begin tapering these meds, as opposed to starting on more of them. If I am going to start taking more powerful pharmaceuticals, I want them to be of the sort that have a fighting chance of fixing the root cause of my problem (such as ATG), not just temporary protective measures, such as neupogen or antibiotics, which have risks and dubious long-term value, especially when given to people who are not getting sick.
Thank you to everyone who read this very long post! I know I need a second hematologist's opinion, but figured I would start here.
Kevin, male age 45; dx SAA 02/2012 - Hgb 5.8, platelets 14, ANC 200, 1% cellularity. Received ATG 03/2012. As of 03/2015, significant improvement - Hgb 15, platelets 158, ANC fluctuates around 1000, Lymphocytes 620. Tapering cyclosporine. BMB 20-30% cellularity.
Hi Kevin,
Unfortunately, I don't really have answers to your questions, but I do have a couple of comments, a suggestion, and a question.
Have you tried getting in touch with AAMDS. They might be able to give you contact #'s for AA specialists throughout the country who might be able to answer your question via phone call or email.
Re: Long-term use of Neupogen--quite frankly (personally) I've never heard of anyone using it for so long. Back in 2004 when my son was dx'ed w/SAA; I recall reading a medical article where it mentioned something to the effect of the use of Neupogen and incidence of relapse. I'm really not sure if "the author" was merely suggesting that there "might" be a connection or if they were just not sure at the time.
I recall being worried because my son was getting a small dose of Neupogen for approximately 5-6 weeks post ATG. In hindsight, I don't think he even needed it as his WBC/ANC rose quite rapidly and WBC was actually at 12.? when his doctor ordered us to stop! It eventually leveled off at around the 5.0-6.0 range. He however, did eventually relapse.
Re: A second round of ATG being administered even though 2 cell line numbers are doing well--That is an excellent question and one that I'm very interested in knowing too!
My son never got a second ATG course. His doctor merely increased/switch brands of CsA and his numbers bounced back. Still, I am concerned about this because like you, 2 of his Cell-lines are in normal range, but his Hgb is still low @ (8.3) ---major concern.
I was under the impression that another round of ATG was not offered bc both his WBC/ANC is within Normal range 6.1/3500 and Platelets are at 141K
Needless to say, he has been on CsA for too long and appears to be CsA dependent at this point.
I know of a few who have had 2+ courses of ATG and are doing very well with long-term remissions.
BTW, were you diagnosed VSAA? I noticed the numbers you posted below fall within that range (I think).
06/2004 my son was dx with SAA at the age of 10. No sibling BM match. He underwent ATG (H)/CsA. Relapsed 05/12 & dx'ed w/PNH. Currently in wait/see mode for Solaris as he is asymptomatic...
Hi NLJabbari,
Thank you for the thoughtful reply! It sounds like your son and I have different yet related problems with our blood counts post-ATG. I am glad he had a multi-year remission after ATG, and that his WBC and platelets are so high. Yet I know firsthand what it feels like to have an Hgb of 8.3 and I really feel for your son there - I found it very challenging to be anemic.
I understand red blood growth factors are typically not recommended in SAA, but since it is just his red blood that is an issue, I wonder if one of those could be of help in raising his Hgb? Has your son's erythropoietin level been taken? Perhaps when that is low, a red blood growth factor would help.
I identify with your frustration about cyclosporine dependence. Since Csa hits the kidneys, I wonder whether that could retard Erythropoietin production, thereby exacerbating anemia in some patients.
One thought on a second course of ATG when only one cell line has crashed - my parents attend an AAMDS support group in New Jersey, and they posed that question there (important note, these are patients, not doctors). But the thought in their group was that a second ATG seemed odd when only the white blood is low, since ATG hits the white blood count so hard, yet if just blood or platelets were low, the patients there thought a second ATG would make sense.
I have contacted AAMDS, and found their materials to be very helpful. I think I have a good list from them of hematologists I'd like to contact with my questions. AAMDS was the first place I learned that my long-term neupogen administration was unusual.
AAMDS had a video of a talk given by an Irish hematologist, I forget his name offhand, saying that long-term neupogen is not indicated in SAA because even if it produces a response, it has no long-term benefit (and perhaps risks), but either way it just is a stopgap preventing the patient from getting the treatment they really need. Dr. Young at NIH published a paper last year, where if I understood correctly, he was even saying the same thing about long term Cylosporine use (I will try to find these links and post them here).
But then, the huge question for your son and I is - what exactly is the treatment that we need? Since 2 out of 3 blood lines are doing well for us, we seem to be in this weird sort of holding pattern.
As for my vSAA/SAA diagnosis, they never really said exactly, I think because I was right on the cusp (ANC < 200, with pancytopenia, means vSAA I believe), and either way the situation was dire and treatment was needed ASAP. My ANC did fall to 0 during ATG administration.
This is such a strange disease. Here are just a few of the many patient anomalies I know of:
1) A vSAA diagnosis gives a poor prognosis in the literature, yet I know a patient who had an ANC of 0 at diagnosis, who responded very well and very quickly to ATG, without any serious infection or complication.
2) A low reticulocyte count at diagnosis is a poor prognosis. My reticulocyte count was almost nonexistent at diagnosis, and my reticulocyte count still runs low. Yet that is the cell line in which I've had the most robust recovery, raising Hgb from under 6 to over 13.
3) My lymphocytes have never recovered. They were well into the normal range pre-ATG, and now run below 500. Of course, those include the nasty aberrant T-cells presumably causing our disease, so we aren't as worried about those being low. Yet still I find it strange, I have not found any other SAA patients who responded to treatment, yet whose lymphocyte counts stay low 1 year + post-ATG.
I wonder whether clues to better treatment lie within these strange anomalies so many of us SAA patients exhibit.
I will keep you posted via this thread on what I learn (or start a new thread), and would be happy to talk with you and your son via email or phone sometime if you'd like (my email is email@example.com). We have an aplastic anemia support group here in the Denver, Colorado area, if you are ever in the area. I will be thinking about you and your son, and hoping we both find solutions to make us 3 out of 3 instead of just 2 out of 3!
Best regards,
Kevin, male age 45; dx SAA 02/2012 - Hgb 5.8, platelets 14, ANC 200, 1% cellularity. Received ATG 03/2012. As of 03/2015, significant improvement - Hgb 15, platelets 158, ANC fluctuates around 1000, Lymphocytes 620. Tapering cyclosporine. BMB 20-30% cellularity.
...something I wanted to add about the cyclosporine though. While stopping neupogen is more clear-cut, it sure wouldn't be an easy decision to stop or even taper the cyclosporine. I know of multiple SAA patients that are dependent upon it for several years, but the cyclosporine keeps them in remission.
My doctor thinks perhaps another round of ATG for me would enable me to get off the cyclosporine. He feels I have some residual auto-immune process that one more ATG could subdue, allowing me to hopefully enjoy a stable long term remission without cyclosporine.
Kevin, male age 45; dx SAA 02/2012 - Hgb 5.8, platelets 14, ANC 200, 1% cellularity. Received ATG 03/2012. As of 03/2015, significant improvement - Hgb 15, platelets 158, ANC fluctuates around 1000, Lymphocytes 620. Tapering cyclosporine. BMB 20-30% cellularity.
Hi KMac,
Yes, I guess 2 out of 3 ain't bad I should be glad that my son actually functions quite well at 8.3 He's only 19 y-o and has a whole lot more energy than I do...or at least it seems like it.
Some time ago, I read something about a program (based on Algorithms) where you plug in all the data that pertains to your AA case and it offers advice/feedback??? I'm not sure where to find this program, but I think a member on this site mentioned it. It sure would be nice if this actually existed and helped out with sorting things out. Perhaps it could answer or bring light to some of these confusing questions. I'll see if I can find that post and I'll share it if I actually come across it. You never know, it might help.
Re: Initial response post ATG. My son responded at around the 5-6 month mark. During this time, he was taking a couple of antibiotics (Oral Nystatin and Bactrim) as part of his post ATG meds. Two weeks prior to this response, I had noticed on the med literature that Bactrim/Septra "Could Cause AA!?" I told his doctor that I was uncomfortable knowing this and I wanted him off this med immediately. So, my son was taken off Bactrim/Septra and now gets a monthly dose of Pentamidine instead. Well, the reason I'm mentioning this is because after he was taken off the Bactrim, his counts began to rise! I'm really not sure if it was a coincidence or if indeed Bactrim was not a good option for him. The first line to respond were his platelets. They took off and he actually reached the 300's, the RBC were next and he reached 13.-, then the WBC. WBC stayed in the 3-4 range for quite a while (years), but than went into the 5-7 range and pretty much has stayed there.
Re: RBC Growth Factors--Not an option as his Retic and erytho, both have recently been tested and are in (Upper Range). It was discovered during his relapse BMB that he has a 20% PNH clone, but it hasn't changed as of yet and his LDH (LACTATE DEHYDROGENASE) is in the 300 range. Lots of baby red cells, but they're not making it into the bloodstream. His doctor said that they didn't find HGB in his urine either, so that's a good thing. Now we're just waiting...hoping this clone doesn't get any bigger...or worst. He should be getting another BMB this summer.
I often wonder if ALL Cyclosporine is created equal...hmmm??? My son was initially on Gengraf (Generic for Neoral). He did well on that and then was switched to Sandimmune. (Kaiser HMO) Now, his new doctor has put him back on Gengraf and thus far we're seeing positive changes. For one, he hasn't needed a blood-transfusion since switching. That's a biggie, since less transfusion is a good thing. Yes, seems like he's plateaued at 8.3 and we're okay with that for the time being.
Thus far he's tolerated CsA pretty well. No high blood-pressure and kidney function is fine. Very grateful for that...
I asked about your diagnosis vSAA vs SAA because, like you said vSAA might equal "initial" poor prognosis, but I recall reading that responders actually do better long-term and overall. I think it has something to do with the fact that if all 3 cell lines are affected at a common rate, all 3 cell lines should respond at a similar rate too and perhaps avoid this "Weird sort of holding pattern" Sort of makes sense...
Indeed this is a very strange disease or disease(s) as some might say. I have a feeling deep within that better treatments and understanding of this disease are in the near future. There are those few that are even brave enough to turn away from CsA, ATG, etc...and opt for Alternative methods. Of course, they are very disciplined and follow strict guidelines. Unfortunately, my son isn't that disciplined. I spend my days badgering him, asking him to please drink his water, fruits, vegetables, no fried foods etc...sometimes I bug him!
So, a second round of ATG and what to do? I think your doctor has a very valid point and yet 2 cell lines doing really well makes you wonder if the 3rd is just lagging for a bit and perhaps even due to one of your antibiotics. I hope you find an answer and that someone will give you good advice.
Take care,
06/2004 my son was dx with SAA at the age of 10. No sibling BM match. He underwent ATG (H)/CsA. Relapsed 05/12 & dx'ed w/PNH. Currently in wait/see mode for Solaris as he is asymptomatic...
Hi Kevin, if you do a search under my name you may be able to find a link to the copy of the Dr Young paper which I referenced when it was published last August, I think. If you can't find it ill try to see if I have a copy and post it again.
Also recommend you try to locate a hematologist who is very experienced with AA.
I would definitely ask about the propholaxes and the GCSF shots. Your dose of the antiviral is higher than mine was post ATG (800 mg 1x day). GCSF shots for me post ATG were only if my ANC fell below 500, so as not to impact my ability to produce these on my own (tho Dr Youngs paper mentioned they will let people go down to 300 if they remain healthy). Propholaxes antibiotics post ATG were only when my ANC fell below 500 because with me, my white cell/neutrophil production was negatively impacted with some antibiotics. Also, some Docs believe being on them too long may make them less effective when needed. I was also NOT on any antifungals post ATG as they have also been known to negatively impact white cell/neutrophil production in some AA patients.
The GCSF is also known to take energy away from platelet production . So whenever I had GCSF my platelet count would fall. It's all a very delicate balance for SAA patients which is why having a hematologist with many years of AA experience is so helpful.
Good luck!!
Age 54; DX Heavy Chain (AH) Amyloidosis 6/10; AutoSCT 3/11; Amyloidosis remission 6/11; DX SAA 7/11; Horse ATG 3/12; Mini MUD SCT 1/13; Recovered from SAA 5/13 & feeling great
Last edited by dfantle : Sun May 5, 2013 at 12:02 AM.
53 yo female, dx 9/08, AA/hypo-MDS, subclinical PNH, ATG/CsA 12/08, partial response. small trisomy 6 clone, low-dose cyclosporine dependent
When I had my ATG I was told never to switch brands because the absorption... varies by brand. I had to convince my insurance company of this, however.
Age 54; DX Heavy Chain (AH) Amyloidosis 6/10; AutoSCT 3/11; Amyloidosis remission 6/11; DX SAA 7/11; Horse ATG 3/12; Mini MUD SCT 1/13; Recovered from SAA 5/13 & feeling great
Thank You Hopeful and Dfantle. Actually, I am aware that not all Cyclosporine is Bio-equivalent in that absorption rates differ. What I'm wondering or am curious about, is if there is something else in the mechanism of the different brands of Cyclosporine. It seems that there are some brands that I hadn't heard of before, that I seem to be hearing more often e.g. Tracolimus and a couple of others. Also, the "modified" brands vs "non-modified". To the best of my knowledge "modified" merely means the pills don't have that stinky skunk-like scent. Makes me wonder what is that smell and why have it at all??? There are brands that supposedly don't swell your gums and no excessive hair-growth. What exactly is happening to the body when the swelling occurs?
This makes me wonder if perhaps there are differences in how they work or not and we just don't know it? My son was initially on Gengraf and responded quite well. He was weened after a year and was off all meds for about 1.5 years when his numbers began to decline once again. Then his doctor put him on Sandimmune. I asked about this, but was never quite clear as to why Sandimmune vs Gengraf which we already knew he had done quite well with. At the time, they told me it was an Immunosuppresent and that I shouldn't worry about it, so I didn't. I just assumed that since "Kaiser" is an HMO, that was the ISD that was available.
Time went by and my son never quite was able to regain the numbers he once had (All within Normal Range). We went up and down for years (about 6 years) until he was in full relapse needing transfusions once again. As if that wasn't bad enough, he was also being transferred to "Adult Medicine" at this time, meaning "New Doctors".
Long story short, the new Dr. didn't work-out for us at all. So, we did further research and found a more experienced Dr.within our HMO who besides being a Hemo specialist also teaches at Stanford University. Within a couple of weeks and by switching CsA brands back to Gengraf; my son has not needed a transfusion and his numbers are slowly rising to where they hadn't been in years. Especially his platelets. They had not been in Normal Range since about 6 years ago! I don't want to cry Victory, but it sure does feel good! The fact that his new Dr. decided to merely switch brands vs opting for another round of ATG--makes me beg to ask, "Are all CsA's created Equal?"
Again, thanks for your input I really appreciate it and I hope I haven't confused anyone.
06/2004 my son was dx with SAA at the age of 10. No sibling BM match. He underwent ATG (H)/CsA. Relapsed 05/12 & dx'ed w/PNH. Currently in wait/see mode for Solaris as he is asymptomatic...
Hi guys,
Since you mentioned bactrim / nystatin and counts, I thought I'd chime in with my experience.
I was first diagnosed with PRCA but now they're calling it AA. I am red cell transfusion dependent. I have tried cyclosporine, IVIG and ATG/tacrolimus and quit all that 2 years ago. I believe (from lots of evidence) that chronic infection may be the cause of these blood disorders.
I tried bactrim ds for a UTI back last Sept and ended up with a fever of almost 104 and a huge drop in HGB. I thought I had the flu but now am wondering if it was the bactrim. I quit the bactrim for awhile and things went back to the way they were.
Anyway, part of my treatment involved taking 1/2 a bactrim ds every 48 hours. I waited until I was over the "flu" I had. The first time I took it, I had a severe reaction including projectile vomiting and fever. I reacted to bactrim over 20 years ago and have always avoided it. My dr encouraged me to try a smaller dose. I waited a couple weeks until I dared try again and then tried 1/8 bactrim ds and had a small reaction but nothing intolerable. I stayed at the dose for several weeks and after each dose I had less and less symptoms. Eventually I increased it by another 1/8. I noticed I had a big drop in platelets, they went down into the 20s, when they had been in the 60's - 90's for the longest time.
Around the same time, I started taking oral nystatin in a fairly large dose, daily. My WBC had been around 1.8 all the time, now dropped to 0.8, 0.7. Neutrophils dropped to 0.3. I've been here since Jan but I feel pretty good.
If this is bacterial, then I am slowly reducing my bacterial/fungal load, and eventually things should improve. I was noticing my HGB drops were slowly becoming smaller, below average, for 8 weeks in a row. I added a 2nd antibiotic - minocycline at 50 mg every 48 hrs and dropped bactrim down to 1/8 again and started ramping up the bactrim every 2 weeks. I got up to 1/2 and suddenly had a big drop in HGB. Platelets range between 30's - 50's, they did dip down into the 20's for a few weeks. I'm currently at 1/2 a bactrim ds and staying here until my HGB drop normalizes.
Anyway, my feeling is that the combo nystatin / minocycline / bactrim is fighting something. I know about the warnings for bactrim, but I wonder if it's because it is actually helping kill microbes, which would also kill the cells they are in.
I am getting a DNA test of my blood soon to test for microbes that can't be cultured, I ordered some kits from ubiome.com. It'll be interesting to see what shows up.
Thanks for letting me ramble. I am actually feeling pretty good these days. I work full time, ride my horse and have a positive outlook. I have no problems with infections even with ridiculously low WBC / ANC, no problems with bruising or bleeding, just the fatigue from anemia every 2 weeks.
This really is a strange disease.
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Recently, space image processing enthusiast Thomas Appéré noticed that Curiosity had taken five photos of exactly the same spot on the rim of Gale crater, identical but for being taken at different times of day. That spot was due north of the rover, so the rising and lowering Sun illuminates the rounded hummocks of the crater rim differently from early morning to early afternoon.
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I was having problems with Mantis being able to send emails using an Office 365 account using SMTP whereas I had other online apps configured and sending emails successfully with the same account. The error being returned was:
In searching the forums I did not find anything useful so I went through the code I and found that Mantis also includes a reply to address when sending the email. This was the critical item causing the issue. Office 365 expects the from address, the reply to email and the username to all be the same email unless you have specifically allowed the user permissions to send as another email address.
Code: Select all
Detail: 5.7.60 SMTP; Client does not have permissions to send as this sender SMTP code: 550
Since I struggled getting Mantis to work with Office 365 I thought I would document the settings you need to make Office 365 work:
Hope this proves to be helpful to others.
Code: Select all
$g_enable_email_notification = ON; #enables the email messages
$g_phpMailer_method = PHPMAILER_METHOD_SMTP;
$g_smtp_host = 'smtp.office365.com';
$g_smtp_connection_mode = 'tls';
$g_smtp_port = 587;
$g_smtp_username = 'email@example.com'; #replace with your email address used to log into Office 365
$g_smtp_password = '********'; #replace with your email password
$g_from_email = 'email@example.com'; # Office 365 requires this to match the username email address
$g_return_path_email = 'email@example.com'; # Office 365 requires this to match the username email address


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showed how vowels and consonants sound as written. A
picture of a stick sufficed to show how s-t sounds. A
picture of a rooster showed how o-o sounds. Rooster,
cooler, goose, loose - but not good, wood or even should.
The kid didn't like it. He resisted every attempt to play
the game. He doubled his tiny fists and hit at the man as
he tried to hug him, saying "I hate this! I hate you!"
It was an extreme action for him to take. He loved the man
and the man loved him. They both loved to play little boy
games and tell each other tall tales. This was new, a
disturbing, painful development. There were neither one
happy with it. The boy was acting out his stress. He
needed help and he showed him because he trusted him to
What to do?
The people at the school recommended a transfer to the
"magnet" school - a polite term for a special needs class of
kids bussed to a town ten miles distant, a class for
retarded kids. Maybe even medication should be used to
correct certain problems in the kid's perceptions and
He recoiled in horror. The little fellow could do much,
much better. He just knew it.
He resisted the notion, told the mother not to accept that.
He had found out how - for a thousand dollars - he could
arrange for the kid to be trained to read at a rudimentary
level at a special literacy project sponsored by a
professional school at a nearby university, a place 35 miles
distant. He had found a decent car for the woman to drive,
arranged for the lessons, the price, the budget. It would
become their project five days a week.
All this had been the subject of several mornings working
the phone, looking up facts and figures on-line. How he
loved to function this way.
Now, the two of them regarded one another at eye level, the
boy standing by his side, he seated at his grandfather's old
mahogany desk with the leather top, his arm around the boy's
"Let's play a game," the man said. He made all his
decisions - the major ones - this way.
"Let's flip a coin."
"What means that." The boy was in the habit of asking
questions by making statements out of syntax. It was his
idea of how to ask a question.
He also liked to simulate telling a joke by telling him
certain things that didn't make much sense. Then saying,
"You know what?"
"You know what?"
"Nothin', that's what!" Then he would die laughing, doing a
zombie dance around the sides of the man's desk and chair.
"It means," the man continued, his voice taking on a
pedantic tone at which the boy waved his hand around, making
it appear to be quacking like a duck, "that I will make the
coin flip through the air -like this. You call it - heads
or tails - while it's still in the air. Then I will catch
it and we will see which it is.
"This is heads," he said, showing the kid George
Washington's bas relief profile.
"This is tails," he said, displaying the spread eagle with
olive branches in one claw, arrows in the other.
He drew out his pronouncements, broadening the vowels,
making the final sounds of the words trail away into fadeout
and dropping his head as he bit off the words as if they
were hanging suspended in the air before his face.
"Oh-kay," the little boy said, grinning at this strange
thing, this funny little proposal.
The coin flashed up, catching the pale afternoon light
streaming through the windows, and while it spun in the air,
the kid stayed silent. The man caught it and showed it to
"Man," said the kid. He was starting to grin broadly. He
was catching on, having fun now. Washington's portrait in
nickel plated copper shone up from the palm of his hand.
The man flipped the quarter again.
This time the spread eagle came up when he uncovered the
coin with his hand. The kid looked at it; he said, "Bird."
"Let's try it again," the man said, smiling easily at the
kid. He didn't always catch on to things the first time.
It took a lot of patience dealing with Billy.
"Except, Billy, you know, you guess if it's man or bird
while the coin is still spinning in the air, okay?"
He flipped the coin.
"Man," the kid said.
He snatched it out of the air, covered it with his hand. The
coin came up heads.
"One more time," he told him.
He grabbed the coin from in front of the kid's face, slapped
it down on the back of his other hand, peeked at it, then
showily displayed it under the kid's nose. The coin came up
"Guess what, Billy. You win."
The kid looked puzzled. He grinned at him as he handed him
the quarter. The kid put it in the pocket of his tiny
jeans, his dirty, tanned little hand disappearing in the
denim folds as he swiped his lengthening hair out of his
eyes with the other. Then he picked up his can of soda from
the desktop and took a deep drink, two-handing it and
throwing back his head.
He belched manfully.
He grinned slowly.
"What did I win?"
"You won the future. That's what you won."
The kid shrugged. He grinned again as he turned to go, the
afternoon sun shining in his eyes and in his hair. He
looked like a little elf standing there grinning at him.
"Tell your mommie I need to talk to her as soon as she gets
home from work, okay?"
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Student research project (Bachelor thesis or internship)
Incorporation of Green Fluorescent Protein into polyelectrolyte complexes.
Polluted drinking water is a timeless, global problem. Water purification is typically done via membranes, separating undesired elements from the drinking water. However, the membrane themselves are produced using (environmentally) harmful chemicals. For this reason a new technique to produce membranes using polyelectrolytes is being investigated. Polyelectrolytes are polymers with charged monomeric units. Mixing oppositely charged polyelectrolytes results in interaction and the formation of (solid) polyelectrolyte complexes.
Chemically, biomolecules such as proteins or DNA have properties similar to polyelectrolytes. These properties allows us to incorporate these biomolecules into the polyelectrolyte complexes, with the hope of eventually producing a polyelectrolyte membrane containing active biomolecules.
In the research for this bachelor thesis project we would like to investigate the incorporation of Green Fluorescent Protein (GFP) into polycationic poly(allylamine) (PAH) and polyanionic poly(styrenesulfonic acid) (PSS) complexes. We have incorporated other proteins into complexes made by other polyelectrolytes and believe there is an optimal PAH:PSS ratio in which GFP is maximally incorporated. We would like to find out what this ratio is. Secondary research questions are whether the activity of GFP is altered (permanently or temporarily) after incorporation and what factors (e.g. temperature, salt, pH) influence the stability of the GFP incorporation.
Project to-do list:
- Investigate the optimal GFP incorporation ratio in polyelectrolyte complexes as a function of PAH:PSS ratio.
- Look at the effect of temperature, salt concentration and pH on the incorporation of GFP.
- Observe if GFP is still active (active = fluorescent) in the complex.
Department: Nanobiophysics (NBP) (nov 2018)
Daily Supervisor: Jéré van Lente, email@example.com
Project Leader: dr. Saskia Lindhoud, email@example.com


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"Mama, can we please buy brussels sprouts"?
This is a question I get every single time we go to grocery shopping. And every single time someone nearby hears and their jaw drops. I feel like the world has an unfair view of brussels sprouts. I mean, what do you think of when you hear brussels sprouts? Soggy? Mush? Flavorless? Well, none of those words describe brussels sprouts if they're cooked properly! Brussels are a delicious way to add color, flavor and texture to a plate. Not to mention that a 1/3 cup serving contains approximately four times more vitamin C than an orange! Wow!
Now, I want you to forget everything you were ever taught about cooking vegetables. In other words, stop boiling your vegetables! Boiling vegetables takes away texture, color, flavor, and much of the nutrients that vegetables have to offer. Instead, try them this way. I promise that they'll add a splash of color to your plate and that they'll quickly become a go-to side!
Begin by chopping off the stems and slicing the brussels into halves. I love slicing my brussels into halves because it gives a nice flat surface for me to brown, adding color and flavor!
Place halved brussels face down in a pan. Drizzle with olive oil and sprinkle with kosher salt and pepper to taste.
Cook 'em till they're golden on the sliced side and then stir them around to get color on the rounded side as well. At this point I generally drizzle with a little more oil, just enough to help them slide around easily in the pan when I give it a shake. Add about a 1/4 inch of water to the bottom of the pan and a clove of minced garlic and simmer until there is no water left.
Ah, yum! Bright and colorful, crisp and full of flavor. These little guys won't last long on your table, I can guarantee it! Enjoy!
Mama to two little ladies and wife to a geologist, Maia is passionate about life and all it entails. She is a cellist, a teacher, and a food enthusiast. She ran a bed and breakfast while she was in high school to save money for college.
Continue reading...


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Espen Moen, BI: Optimal Taxation with On-the-Job Search
Department seminar. Espen Moen is a Professor at BI. He will present a paper entitled "Optimal Taxation with On-the-Job Search", co-authored by Jesper Bagger, and Rune M. Vejlin.
Espen Moen. Photo: BI
We provide a theoretical and empirical study of the optimal taxation of labor income in the presence of search frictions and unobservable amenities using comprehensive Danish matched employer-employee data. Heterogeneous workers undertake costly search off- and on-the-job in order to locate more productive jobs that pay higher wages. More productive workers search harder, resulting in equilibrium sorting where low-type workers are overrepresented in low-wage jobs while high-type workers are overrepresented in high-wage jobs. Absent taxes, worker search effort is efficient, because the social and private gains from search coincide. The optimal tax system balance efficiency and equity concerns at the margin. Equity concerns make it desirable to levy low taxes on (or indeed, subsidize) low-wage jobs including unemployment, and levy high taxes on high-wage jobs. Efficiency concerns limit how much taxes an optimal tax system levy on high-paid jobs, as high taxes distort the workers' incentives to search. Using detailed micro data on wages, labor market transitions, and income tax filings we estimate the structural model and compare the the actual Danish tax regime with the optimal one. Preliminary results suggest the optimal tax schedule exhibits less progressivity than the actual tax system in place. The model allows us to quantify the welfare gains from adopting an optimal income tax schedule.
Host: Gaute Torsvik


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Educational Holiday Activity Ideas from Your Favorite Preschool
The talented staff at Rosewood Academy in our Carrollton, Dallas and Frisco locations, promote education outside of the classroom whenever possible, and pride themselves on providing a nurturing, creative environment for children to play and learn. The holiday season means children of all ages are home from school, and if wanting to encourage learning while children are on break from preschool, check out a few ideas for your pre-kindergarten kiddies:
- December Holidays: Teach your children about holidays from different cultures. Numerous holidays are observed in December in addition to Christmas, including Hanukkah, Kwanzaa, and the Winter Solstice. If interested in broadening your children's holiday horizons, consider creating traditional dishes together, reading books about December holidays during story time, or finding crafts centered around various celebrations.
- Holiday Questions: Find answers to holiday traditions, such as "Why do we hang stockings by the fireplace?" and "Who made the first candy cane and why?" Ask your children if they have any questions about Christmas traditions they'd like answered, and use assorted books and reputable websites to learn more about the celebrated holiday.
- Nature-Centered Crafts: Instill a love of nature in little ones by taking walks on nearby nature trails. Pick up fallen twigs, evergreen sprigs, and anything else that contributes to a "natural" Christmas tree. Remember to only use fallen objects, and create crafts for the Christmas tree in your home. If your property features an evergreen, consider having the children decorate it with their crafts.
- Community Service: Discuss the importance of giving back and helping the community with your kids. Talk about the many ways they can "be Santa" for others, and see if they don't come up with their own ideas, such as donating presents to needy families.
These are just some of the ways to emphasize educational fun during the holidays. Talk about options with staff at our Carrollton, Frisco or Dallas area preschools, and know you're doing your part to keep young minds stimulated when not at school.
For more on Rosewood's preschool curriculum, extra curricular activities and community involvement, please contact Rosewood Academy today. Call (972) 512-9880 , or visit our website .
Rosewood Academy Shares 3 Ways Holiday Celebrations & Early Childhood Education Connect
Rosewood Academy is the premier preschool in Carrollton, Dallas, and Frisco, TX. Offering early childhood education opportunities for children ages six weeks to five years, these experienced instructors have the resources and the skills to prepare your kids for elementary school and beyond. If you're looking for quality childcare in the local community, contact Rosewood Academy to give your kid the jumpstart that they need at such an early age.
Should I celebrate the holidays with my children? To discover how participating in holiday events is important for your child's growth, check out the following benefits, brought to you by the early childhood education experts at Rosewood Academy:
- Traditions & Values: When you celebrate the holidays with your kids, they learn about important traditions and values shared by people in their community. Additionally, learning about these holidays provides children with a great opportunity to learn about the rich cultural history behind each and every occasion.
- Family & Friends: Regardless of what holiday it is, there is usually one common thread that makes all celebrations inherently similar, which is their social element. Show your children how to celebrate the holidays and watch as they strengthen bonds with family members and build long-lasting friendships with their peers.
- Multicultural Education: While all people don't celebrate the same holidays, each and every occasion provides an opportunity to explain to your kids the differences between people of different nationalities, religions, and races. Some people use this as a time to experience other culture's traditions while others prefer to learn more about these from an "outsider's" perspective.
No matter what holidays your family celebrates, everyone is more than welcome at Rosewood Academy . To learn more about their preschool program and specifics about early childhood education for your child, contact these experienced teachers at (469) 522-3739 (Dallas) , (469) 287-8076 (Frisco) , or (972) 512-9880 ( Carrollton). You can also visit their website for more details.
Rosewood Academy Testimonials: Early Childhood Education at Its Best
When you're looking for the best early childhood education options for your child, researching daycare centers and preschools can be overwhelming. Each school has its own philosophy and practices, and finding the perfect Dallas location is often a challenge.
Fortunately, Rosewood Academy has schools in Dallas, Frisco and Carrollton for convenient access to high-quality early childhood education. Highly qualified and caring teachers use a traditional preschool curriculum combined with Montessori elements, to support a well-rounded education that includes language and literacy development, early math skills, fine arts and physical education.
Not sure if Rosewood Academy is right for your child? There are plenty of glowing testimonials from happy Texas families. Anna L. of Frisco loves how much her son has learned. "Our son has learned more than we could have imagined, and all of the staff is so loving and attentive to each child. We couldn't have picked a better place to send him."
As Casey H. notes, Rosewood wants the parents to be just as involved as the children. "Rosewood's commitment to family and providing great opportunities for parents to be involved in is just another reason that we can't imagine a better place to entrust the care of our little one."
Parents and children alike love the facilities and learn so much: "The new Rosewood Academy in Dallas is beautiful and clean, and the teachers are very knowledgeable and attentive. My daughter loves going to Rosewood and I have seen such a drastic improvement in her focus, math skills, and even her overall behavior!" – Stacy A., Carrollton
Mark T. of Dallas agrees, and notes how accomodating the preschool is: "Both of our kids are learning much more than we had hoped, and I love that my oldest is even learning sign language! My wife was concerned about going back to work and leaving our youngest, especially since she isn't formula fed, but Rosewood has a private nursing room that allows her to breastfeed our daughter easily and comfortably."
To find out more about why Rosewood Academy is a great choice for Dallas area families, and to learn more about their great curriculum, call or visit their website . To schedule a tour, call the Dallas school at (469) 522-3755 , the Frisco school at (469) 605-2437 , or the Carrollton school at (972) 810-6597 .
Rosewood Shares 4 Ways That Preschools Promote Positive Social Development
Rosewood Academy is a beacon in early childhood education. With three locations in Texas—Carrollton, Frisco and Dallas—this preschool offers comprehensive childcare services for children who aren't yet old enough to begin kindergarten. If you're looking for an upstanding preschool in your community, schedule a visit at Rosewood Academy today.
How can I socialize my child? Rosewood Academy is here to help. Based on current studies in early childhood education, check out the following ways in which child care services promote proper social development in children, brought to you by Rosewood Academy:
- Gain Social Skills: When your child attends Rosewood Academy, they learn the necessary social skills to thrive in school, make long-lasting friendships and transition from maternal care to the non-domestic environment.
- Prepare For Kindergarten: In order for children to properly adjust to elementary school, parents can get a head start on socializing their kids by enrolling them in a high-quality daycare center like Rosewood Academy.
- Decrease Problem Behaviors: Studies have shown that children that don't get an opportunity to socialize before elementary school can possess fewer social skills, poorer work habits, and conflictive attitudes.
- Eliminate Attachment Insecurity: If you think you're doing your child a favor by giving them all of your love and attention, think again. When you enroll your child in Rosewood Academy, you're giving them the tools that they need to succeed as an individual by placing them outside of their comfort zone.
To learn more about the early childhood education programs at Rosewood Academy , visit them online , or call their office today at (469) 522-3739 (Dallas), (469) 605-2437 (Frisco) or (972) 810-6597 (Carrollton).
3 Tips for Promoting Healthy Physical Development, From the Child Care Experts at Rosewood Academy
Your little ones are boundless wells of energy—playing, exploring, jumping, dancing, tumbling, and getting back up. Because early childhood is a crucial period of physical development, it's important to encourage your kids to engage these energetic impulses and find active outlets to help them keep moving and developing their fine and gross motor skills. At the Rosewood Academy daycare center and preschool in Texas, fun physical activity is a major part of everyday early childhood education.
Read on to learn three ways to encourage healthy physical development at home, from the child care professionals at Rosewood Academy:
- Make Time For Exercise: Be sure that movement and physical activity play a regular role in your family routine. Taking a family walk, building forts, and staging relay races are all fun ways to get the whole family moving.
- Get Loud: Quiet time is an important part of childhood—and a sanity-saver for parents—but noise is a healthy part of play, and kids need the freedom to indulge in occasional noisy, vigorous playtime to burn off energy.
- Limit Screen Time: Kids today are surrounded by screens of all sizes, from TVs to tablets. Unfortunately, the sedentary lifestyle associated with these various devices has overtaken the vibrant lifestyle kids need. Placing limits on screen time will have a positive effect on children, encouraging them to get up and seek other more active pastimes.
Rosewood Academy is proud to serve the Dallas area with top-quality preschool curriculum blending Montessori and traditional early childhood education styles. To learn more, call the preschool daycare center at (972) 512-9880 (Carrollton), (469) 522-3739 (Dallas) or (469) 287-8076 (Frisco), or visit their website .


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Auto-Disable the Touchpad When Connecting a Mouse in Windows 10
If you're using a Bluetooth or external mouse on your Windows laptop, the touchpad can become a bit of a nuisance. Luckily, it's easy to automatically disable the touchpad anytime a mouse is plugged in.
This method might differ from one manufacturer to another — in some cases, toggling the touchpad on and off is achieved through manufacturer specific settings rather than through Windows settings.
Generally, with most laptops, you can switch the touchpad off by going to Settings > Devices > Touchpad. Under Touchpad, you can toggle off this setting: Leave touchpad on when a mouse is connected.
Anytime you plug in a wired mouse or a bluetooth dongle for a mouse, the touchpad will automatically switch off.
Not all Windows 10 machines have this option. On Dell Machines for example, you'll have to go to Settings > Devices > Mouse and Touchpad and click Additional mouse Options to open up Dell's Mouse Properties. You can also reach this window in your Task Manager.
Click the link that says Click to change Dell Touchpad settings. You can turn on the Dell TouchGuard which prevents unwanted gestures while typing, or you can just simply switch it off completely.
Do you prefer to disable the touchpad when you use an external mouse? What other tips and tricks do you find invaluable for your Windows 10 machines? Let us know in the comments.
Related topics: Computer Mouse Tips, Windows 10, Windows Tricks.
Affiliate Disclosure: By buying the products we recommend, you help keep the site alive. Read more.


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Bar & Eatery
A vibrant and friendly waterfront bar and eatery, great for a social catch up year round.
From tapped international beers such as Heineken, Tiger, Erdinger, Lagunitas to our range of local crafts from Black Dog, Tuatara & Monteith's. And with an extensive wine list featuring NZ and international, it's the perfect to meet for after work drinks every day of the week.
Expect to bump into locals from the surrounding business district for working lunches, after work drinks and dinner. On weekends there's a lively atmosphere from relaxed brunch, lunches through to evening drinks, dinner and late nights. Our outdoor tables are the perfect place to eat, drink, and soak up the sun while watching the world go by.
Our drinks range is impressive, with a noteworthy selection of Gins and tonics. Ask about our tasting paddles and take a voyage of Ginspiration with us, or explore our interesting whiskey collection.
Check out our Menu here or to make a booking, click here.


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First of a couple of concert uploads for this weekend. Summer 1983 sees Prefab Sprout playing to a slightly disinterested home town crowd, judging by the chat and clinking of glasses at least, and with Graham Lant believed to be on drums.
The set contains the by now usual nucleus of songs, but nice to have a recording of a live performance of "Radio Love".


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Officially the street is called Via del Fosso, in the singular form, but for all locals in Lucca it is known as "Via dei Fossi" in plural, because after the first part of the street section, interrupted by the widening of the Madonna dello Stellario, a second part continues up to the walls.
Luoghi di interesse
You are here
Villa Bernardini, built by Bernardo Bernardini in 1615, is a remarkable example of late Renaissance architecture.
The 16th-century Villa Bottini is located in the historical centre of Lucca.
Villa Grabau was built by the wealthy merchants of Lucca, the Diodati family, on the ruins of a medieval village, and it was then sold in 1868 to Carolina Grabau, wife of a wealthy German banker.
Built as Villa Segromigno, it was bought by the Mansis in the seventeenth century.


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Cloud Inventory® is DSI's one cloud-based solution that is designed to manage inventory, streamline supply chain operations, and gain global visibility. This self-paced course is packed with 50 product demo videos including desktop and mobile-device examples and covers a wide variety of day-to-day Cloud Inventory® operations including Inquiry, Inbound, Inventory, Kitting, and Outbound operations. With this course, users will be able to broaden their overall product knowledge and utility in Cloud Inventory®.
No upcoming courses for this class have been scheduled. You may subscribe to unlimited self-paced online training below.


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A 29 year old Spanish woman is currently under investigation by the Civil Guard's Nature Protection Service (SEPRONA) after irregularities were found in the veterinary records of several dogs, which had been taken to veterinary clinics in Orihuela and Santomera (Murcia).
It is believed that she had been selling dogs and cats of many different breeds for over six years with false health documentation.
Agents investigated the origin of each of the animals found with false documentation, every one of which had been bought online.
Their enquiries led to a 29-year-old woman, who had been selling dogs and cats of different breeds for at least six years. On this occasion, there were two chihuahua puppies that she delivered along with a falsified health card that, despite having the vaccine sticker, did not have the signature or the license number of the corresponding collegiate veterinarian.
The woman has now been charged with crimes of intrusion and the falsification of documents.


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Space Access 2009 - Why Homeschool -
Long time readers know that each Spring I head to Arizona to attend Space Access 2009. This year I'll again fly with my father. One of my brothers will join us in Phoenix.
As for me at Space Prizes, I went the last 2 years, but I doubt I'll go this year, as there's a lot to do at home with a 6-month-old who we've just found out has allergies.
Also, the list of speakers at Space Access '09 was updated yesterday.


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JACKSON — Nearly half of Mississippi high school students met or exceeded expectations in English last year, while about 27 percent did so in algebra I, according to test results released Thursday.
Those are the first findings from Mississippi's only administration of a multi-state test meant to measure achievement under new academic standards.
The results are a big drop from the 2014 state tests, when 83 percent passed the previous Mississippi-only algebra test, with 76 percent rating proficient or advanced. In English, 72 percent of students passed in 2014, with 56 percent were rated proficient or advanced.
The drop was expected, though. State Superintendent Carey Wright said standards on Mississippi's old tests were too low.
"Our cut scores are not going to be below proficient," she said.
Last spring was the only time Mississippi will administer the test designed by the Partnership for Assessment of Readiness of Colleges and Careers. In 2016, Mississippi will begin giving a test custom-written by Questar Assessment.
Wright said Mississippi students did "extremely well" compared to results released so far by PARCC states in English language arts for sophomores, and were roughly in line with what other states have released in algebra I.
"Our children are just as capable or more capable as children in any other state in the nation," Wright said.
From lowest to highest, PARCC's score levels are described as not meeting expectations, partially meeting expectations, approaching expectations, meeting expectations and exceeding expectations. There was wide variation among Mississippi's 145 school districts. On the bottom end, Clarksdale and Yazoo City had no students who met or exceeded expectations in algebra, while at the top end, more than two-thirds of students reached those levels in Gulfport, Forrest County and Enterprise.
"There were some pleasant surprises in there for some of the districts, and it wasn't as bad overall as I feared it would be," said Rachel Canter. She leads Mississippi First, a nonprofit group that advocates for education improvements and has been critical in the past of low standards. "I think it does show there are some school districts that are doing what they need to be doing."
The tests also serve as end-of-course exams for students taking those subjects. Wright said the department decided, without a vote by the Board of Education, that a 3 would serve as a passing score for graduation purposes. That means roughly 40 percent of all students, or 17,000 statewide, failed the algebra test, while 27 percent failed the English test.
Formerly, students had to pass four subject area tests to graduate, but in 2014, the Board of Education approved alternative paths to a diploma. This year, students can also average their scores across one or more tests to create a composite score. Thus, students who failed the algebra exam could still graduate if they had done well enough on the biology, English and history exams.
Spokeswoman Patrice Guilfoyle said students who don't meet other graduation options will be able to try again on the state's new exams, but won't retake the PARCC tests.
The state is preparing letters for school districts to send to parents explaining the new test results, as well as information for teachers. Wright and state assessment director J.P. Beaudoin said that even though Mississippi won't give the PARCC again, they want teachers to use the results to help identify strengths and weaknesses of individual students and help them improve.
PARCC test results for grades 3-8 will be released Dec. 17, and A-to-F school accountability grades will released next year.
… we'd like to ask for your support. More people are reading the Mississippi Business Journal than ever before, but advertising revenues for all conventional media are falling fast. Unlike many, we do not use a pay wall, because we want to continue providing Mississippi's most comprehensive business news each and every day. But that takes time, money and hard work. We do it because it is important to us … and equally important to you, if you value the flow of trustworthy news and information which have always kept America strong and free for more than 200 years.
If those who read our content will help fund it, we can continue to bring you the very best in news and information. Please consider joining us as a valued member, or if you prefer, make a one-time contribution.Click for more info


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Awesome Phuket
Welcome to pearl of Andaman, Phuket! One of the most visited place in South East Asia, famous for its pristine white sand beaches & picturesque serene setting. The island is home to many exquisite seaside resorts, spas and restaurants along with nightclubs, bars and discos to lift your spirits. It is filled with old shop houses and busy night markets, where one has the freedom to explore the city's unique nocturnal charm. Known immensely for its nightlife, Phuket also has a new theme park called Phuket Fantasea that promises to be the ultimate nighttime entertainment venue on the island.
**Rate Information: This cost is for one person on a double/twin sharing basis.
Reviews 0 Reviews0/5
Vacation Style Holiday TypeCultural, Explorer
Activity Level Leisurely
|Package Code
|Travel Style
|Explorer, cultural,Family
|No. of Cities
|Activity level
|Number of Nights
|Starting city
|Ending city
Trip At A Glance:
- Day 1:
12:00 hrs – Transfer from Phuket Airport to Phuket Hotel
13.00 hrs – Hotel Check-in
- Day 2:
07.30 hrs – James Bond Island Day Tour with Sea Canoe by Big Boat
16:00 hrs – Back to Hotel, Overnight stay in Hotel
- Day 3:
18:00 hrs – Phuket Fantasea Show
- 23:00 hrs – Back to Hotel, Overnight stay in Hotel
- Day 4: Day at Leisure
- Day 5:
- 10:30 hrs – Travstore Original Phuket Discovery Tour
17:00 hrs – Back to Hotel, Overnight stay in Hotel
- Day 6:
17.00 hrs – Siam Niramit Show
21:00 hrs – Back to Hotel, Overnight stay in Hotel
- Day 7: Day at Leisure
Day 8:
12.00 hrs – Check Out from the Hotel & transfer to Bangkok Airport
- Day 1:
7 Nights Accommodation with daily breakfast in Phuket
- James Bond Island Day Tour with Sea Canoe by Big Boat on SIC basis
- Phuket Fantasea Show with Dinner on Private basis
- Travstore Original Phuket Discovery Tour on Private basis
- Siam Niramit Show Phuket with Dinner on Private basis
- Phuket Airport to Phuket Hotel on Private basis
- Phuket Hotel to Phuket Airport on Private basis
Travel Insurance:
- Travstore offers Travel Insurance
Terms & Conditions:
- Rates are valid for 2 travelers traveling together
- For Private tours & Transfers, Van will wait maximum 30 mins from confirmed time, if transfers are missed; guests are required to reach attraction on their own. Arranging transfers will attract additional surcharge.
- All rates are for base category rooms only
- All rates are applicable for Middle East Market Only
- Rates are valid for Travel between 01st April 2017- 31st October 2017
- Things not mentioned in inclusions
- This package doesn't include any flight costs. You are required to arrange for your flights.
Day 1
Arrive in Phuket
Arrive in Phuket & proceed for Visa on Arrival. If you already have the visa beforehand, please proceed through the Exit gate and meet the Travstore representative for your transfer pick up. After a 45-minute drive, you will reach your desired hotel & check in.
Day 2
James Bond Island Tour
Get ready to witness mother nature's miracle by visiting the world renowned James Bond Island. It is erected straight out of the emerald green waters with a thin base and broad top. You will be amazed to know how it is not falling off as this thought has left many intellectuals head scratching. Also the 1974 classic flick James Bond (The Man with the golden gun) climax was shot on this very island.
- Breakfast in Hotel
- Lunch during James Bond Island
Things to Remember:
- James Bond Island tour – Full day – 8 hrs
- DO'S – Bring sun block lotion or spray with you to lessen the chance of getting a sun burn or a tan. Carry small and fold-able umbrellas.
- DON'T – Don't forget to carry nausea tablets for sea sickness.
Day 3
Phuket Fantasea Show
The Phuket Fantasea Show is a Las Vegas style theatrical show which showcases the beauty and charm of Thailand as well as the ancient Thai traditions with state of the art technology and special effects. The theme park is spread across 140 acres and is packed with an array of activities such as carnival games, street shows, handicrafts demonstrations, shopping village and many more. It's no wonder that Phuket Fantasea was the winner of Thailand's "Best Attraction Award" because it takes theme park entertainment to another level with attractions not found elsewhere in the world!
- Breakfast in Hotel
- Dinner at Phuket Fantasea Show
Things to Remember:
- Phuket Fantasea Show – Evening show
Day 4
Day at Leisure
This day we leave to yourself where you can explore and discover the city all by yourself. You can visit some local markets and get some exciting gifts for your loved ones. Relish some of the local dishes with authentic Thai influence.
- Breakfast in Hotel
Day 5
Travstore Original Phuket Discovery Tour
In this tour, we make sure all your senses get replenished; you get to experience best of Phuket culture, taste the local Thai food, face off with serene landscape & shop the best what Phuket have to offers. Be prepared for a scenic drive across the island, gazing through the local way of life, and glimpsing important landmarks. Come & Explore Phuket Island with an Insider!!!
- Breakfast in Hotel
Things to Remember:
- Original Phuket Discovery Tour – Half Day – 6 hrs
Day 6
Siam Niramit Show
Siam Niramit is a must-see dazzling show with over 100 performers, magnificent set designs and lavish costumes. The show is divided into 3 acts that take you back to when Thailand was Siam and the Lanna Kings ruled in the north and also how the Thai's perceive heaven and hell. Siam Niramit uses enhanced effects and the latest technology which makes the experience realistic, stimulating and visually
- Breakfast in Hotel
- Dinner at Siam Niramit Show
Day 7
Day at Leisure
This day we leave to yourself where you can explore and discover the city all by yourself. You can visit some local markets and get some exciting gifts for your loved ones. Relish some of the local dishes with authentic Thai influence.
- Breakfast in Hotel
Day 8
Departure from Phuket
Today, Enjoy lavish breakfast at Hotel then you will be transferred to the airport for your onward journey. We trust that you enjoyed your Vacation.
- Breakfast in Hotel
Option 1 – 3 Star hotel: $382 per person on double sharing
- 7 Nights in Ibis patong in Phuket(Standrad Room)
Option 2 – 4 Star hotel: $530 per person on double sharing
- 7 Nights in Banthai Beach Resort in Phuket(Superior Room)
Option 3 – 5 Star hotel: $832 per person on double sharing
- 7 Nights in JW Marriott Phuket in Phuket(Deluxe Sala Garden View)


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Life can be a balancing act for any adult, but if you find yourself constantly late, disorganized, forgetful, and overwhelmed by your responsibilities, you may have attention deficit hyperactivity disorder (ADHD), previously known as ADD. ADHD affects many adults, and its wide variety of frustrating.
Sep 26, · Symptom Tests for Adults [Self-Test] Do I Have ADHD? ADD Symptoms in Adults. Do I have ADHD? Take this free adult ADD test to gauge whether the symptoms of attention deficit hyperactivity disorder might explain your habitual disorganization, lack of productivity, poor memory, bad time management, and struggles with money and with work.
Jul 11, · The fact is as many as two-thirds of children who have ADHD continue to experience symptoms of ADHD into adulthood. Because ADHD can be difficult to diagnose and so many believe that ADHD is a childhood condition, many adults attribute their struggles to stress or the fast-paced world of today, when instead they may be symptoms of undiagnosed ADHD.
Adults with ADHD may have difficulty following directions, remembering information, concentrating, organizing tasks, or completing work within time limits. WebMD describes what adult life with.


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Doing a capstone paper is a very important part of your studies and it will determine how you finish your high school journey. There are many rules and requirements that need to be followed when writing this paper, and you should pay careful attention to these if you want to avoid mistakes. Your grade for this paper is vital and it is best to plan and prepare before you jump into it. Through the years, we have seen the same mistakes being repeated by students, and it is easily avoidable if you know what to look out for. Here are some of those mistakes that seem to always pop up.
- Improper citing
By the time you start writing your capstone paper, you should understand the importance of citing your work properly. Taking credit for someone else's work is strictly discouraged, and you should always be sure to give credit to your sources. If you do not do your citing properly, you could be accused of plagiarism, and that would greatly affect your marks.
- Too much quoting
There is nothing wrong with including quotes in your capstone paper, but be careful to not use too many. You want to give your own opinion on your findings and not include too much of what others have stated. This is a research paper, so you should be able to discuss the reason for including the quote. Do not use quotes to fill up some space, but instead use them only when needed to discuss your thesis.
- Incorrect format
Before you start your project, look at some capstone paper examples and take note of the format used. You want to be sure that you do not lose marks for using an incorrect format. A lot of schools prefer the APA format, but this comes with a lot of format rules that you should be aware of. You cannot simply write this paper like you would an essay. There is a specific format and structure that needs to be applied.
- Poor thesis
The whole idea of a capstone paper is to show off your research skills and analytical thinking. If your thesis is broad, your writing may become excessive. However, if your thesis is very narrow, you may not be able to write as much as you can to reach the minimum word count. Do not rush the process of coming up with a thesis statement, because this is the foundation of your paper.
- No proofreading
If you are going to write anything, you should count proofreading as part of the process. Many students do a really good job with their research papers, but then fail to go over their work and make sure all grammar mistakes are corrected. You can save yourself a lot of marks by simply doing a quick proofread and edit.
- Excluding what you learned
In your capstone paper, you want to be able to showcase what you have learned during your course. Include some skills that were covered and do not simply write a watered down essay. This is your final project of the course and you have to give it your all. Even if it is for the sake of your professor feeling special, just make it known through this project that you are ready to practice in your chosen field.
Do not underestimate the time you would need to dedicate to this project. Just because you see the length of time given does not mean that it is not going to run out on you. Start early and do all the necessary prep work. Look at a capstone proposal example or two to get your head in the game.
- Nothing new
Try to add some value to your capstone paper and don't just include the same old information that has been covered a thousand times. You want to be controversial, with facts that back you up. If you want to stand out and receive an excellent grade on this project, you have to do something that no one else has done before. A great way to do this is to come up with a new thesis that no one else has discovered yet.


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Every Bathroom is such a personal space. Its where you wash the kids up after a day of sports and where you go to unwind in a hot shower after a long day. We know this and that's why we can give you the ideas, products and build the space to fit your exact needs and wants.
We know that your day begins and ends with the bathroom. We start by looking at your existing space, listening to your request and understanding what we need to do to fulfill you needs.
What we do
- ✔ Free in home consultation to come up with a complete plan for your new bathroom.
- ✔ Full comprehensive design by National Kitchen & Bath certified and trained designers that specialize in bathroom remodeling and current trends.
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- ✔ Source all of our bath and Plumbing items from a National Buying Group, so we are priced just like the Home Centers.
- ✔ Offer a sophisticated cloud-based project management software that gives you real-time, 24/7 access to project schedules, and updates.


text: [OA] Sex in Sport Doriane Lambelet Coleman & Kimberly D. Krawiec, Foreword, 80 Law and Contemporary Problems 1-5 (2017). Available at: "Foreword" by Doriane Lambelet Coleman and Kimberly D. Krawiec Historically, debates about what it meant "to be a woman" for purposes of sport were largely confined to elite sports circles. That changed in 2009, when it was announced that South African runner Caster Semenya, the just-crowned world champion in the women's 800 meters, had been subjected to gender verification testing. Fellow competitors were outspoken: Semenya was not a woman, they said, and it was unfair to allow her to compete in the women's category. "These kind of people should not run with us," said Italian runner Elisa Cusma, "For me, she is not a woman. She is a man."1 "Just look at her," said Russian runner Mariya Savinova.2 The controversy set off debates around the world about whether and why sex segregated sports are justified and how eligibility determinations for the women's category should be made. Suddenly, in social media and the popular press, at coffee shops, and in chats at the local grocery store, people who had rarely paused to question issues of biological sex, gender identity, or affirmative action in sports debated Semenya's case, and what it meant for conceptions of binary sex categories. It also inspired this volume, in which scholars from gender studies, law, philosophy, and biology bring insights to bear on an issue that is important, not only to sport, but to cultural debates about gender and sex more broadly. … Taken together, these multidisciplinary approaches to the common question of sex in sport should inform contemporary debates about the relative salience of biology in the different institutional spaces that comprise this world. The issue's authors provide relevant factual background from their respective areas of expertise and offer arguments from those disciplines about how policymakers within and outside of sport should assess and resolve the debates. Because sport has significant cultural currency and cross-cultural significance, we expect that these contributions and the processes by which they are generated will also have salience as questions about sex and identity are addressed in the non-sporting contexts in which they also arise. Sex in Sport. Law and Contemporary Problems. 2017;80(4). Law and Contemporary Problems | Journals | Duke Law


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Monday morning. Went to pick up my new Mac, the one I bought last Thursday from a dreadlocked yogi at the Apple store who told me he dreamed he was a phoenix. "But no one can interpret my dreams," he said. When he was a phoenix, he flew around a room with a lot of other birds. He was eager to die and be reborn. I told him I didn't know what it meant, but that I was confident his psyche was in good shape. Read More
BLOG: SWANS LAST DIVE (inactive) Please see my Crooked Mirror blog www.crookedmirror.wordpress.com
First Entry on my Blog
October 27, 2008


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It's been announced that VAMPS will be making an appearance at the outdoors festival 'Download Festival 2014' in England which will be held from June 13th to the 15th.
This year's 'Download Festival' will headline Aerosmith, Avenged Sevenfold, and Linkin Park, as well as Japan's Crossfaith and coldrain. VAMPS will be performing on the 'THE PEPSI MAX STAGE' on the 14th.
The band is also getting ready to perform their 2nd London concert on March 28th. They held their first in October of last year, making their upcoming festival performance their 3rd England show in one year.
Source: natalie


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In the Great Commission Jesus tells us that there are two steps in making someone a disciple.
Go therefore and make disciples of all the nations, baptizing them in the name of the Father and of the Son and of the Holy Spirit, teaching them to observe all things that I have commanded you; and lo, I am with you always, even to the end of the age." Amen.
This section contains studies which are designed to help with that second step: "Teaching them to observe all things" that Jesus commanded.


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2021 SNA Conference
The 2021 SNA Conference will be held once again at the Baltimore Convention Center on Monday and Tuesday, January 4 - 5, 2020, preceding the Mid-Atlantic Nursery Trade Show (MANTS) on Wednesday, January 6 - Friday, January 8, 2021. More information will be available soon.
COVID-19 Resources
During the Coronavirus, COVID-19, challenge we know there are many questions and uncertainties relating to you and your business. In an effort to supply you with current updates and resources to help you make the best decisions for your business, we offer these resources. We will continue to provide additional links and updates as they become available.
Center for Disease Control
We pray for the well-being of you and your families, and for the least amount of disruption to our industry.
$18,000 in Scholarships Awarded to 12 Students
The Sidney B. Meadows Scholarship Fund, created in 1989 by the Southern Nursery Association (SNA), has announced the names of twelve students from nine southeastern universities chosen to receive academic scholarships this year. Five of the awards are named scholarships honoring past industry leaders, including the new award named to honor Dr. Bryson L. James for the 40+ years of service to the Southern Nursery Association as Director of Horticultural Research. Each award of $1,500, totaling $18,000, has been presented to the following excelling scholars:
2 Days Before MANTS
SNA Announces
Upcoming Events
QuickLinks to our member directory.
Platinum, Gold and Silver Members opt to pay an additional amount beyond the normal member dues. This additional amount helps support the association.
Platinum Members
Gold & Silver Members
Platinum Members elect to pay 4X the annual dues amount (or $500 annually). Gold Members elect to pay 3X the annual dues amount (or $375 annually). Silver Members elect to pay 2X the annual dues amount (or $250 annually).
Platinum, Gold and Silver Members are featured on the SNA website homepage and receive special recognition through a second online listing within that membership category, as well as in the SNA eNews that is distributed to more than 9,000 industry members. Your extra dues make a difference to the association and to your business!
We are delighted to have you support our association through any level of membership you may choose!


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Internal Posture – Poise of Consciousness
The following is a guest post written by Arpan.
We all know the usual meditation instruction for shikantaza: just sit.
What does it mean? Does it just mean "physical sitting"? If so, then how is it different from me sitting and daydreaming? Or is it a metaphor for something deeper, as is the case with much that is associated with mysticism?
As is the nature of the human mind, this simple meditation instruction has been the subject of endless hair-splitting over the centuries. An ocean of literature has been written on it and its variants and a world of gradations and maps has been developed to either assess one's level of progress or to assess one's readiness to even start this practice. I would not scoff at the complexity of thought going into this entire work, since it is nothing but an attempt to capture some fragment of truth that can entirely be grasped only in real-time experience – but I wish to remove much that is chaff to our wheat.
The fundamental principle: An ideal teacher tells you what you need, but knows that regardless of what you are told, you will hear only what has a correspondence with your current level of consciousness.
There is an ancient Hindu anecdote wherein the King of the Gods and the King of the Titans went to the Creator Brahma, and asked for the knowledge of the Ultimate. Both are instructed to look at their reflection in a mirror. The Titan King looked at his reflection and concluded that this very body is the ultimate truth, and went on to preach the gospel of hedonism. However, the King of the Gods could sense the inadequacy in that instinctive conclusion and went back to Brahma with his doubts, whereupon Brahma told him: "You are ready for a higher reality. [Note: The instinctive conclusion is not being denied as false.] That within you which is not altered in wakefulness, dream or sleep, that which remains immortal and blissful at all times and in all places, is the Ultimate, is the Atman."
Body and mind are not two fundamentally different realities. They are part of the same continuum ranging from gross to subtle. Whatever posture or activity your body takes up has a corresponding impact on the mind, and vice versa. For someone who is near completely identified with the cerebral process, just the mere act of sitting physically still would reveal to him the million micro-urges in the bodily nerves to "do something", which correspond to the million-strong unnoticed moment-to-moment micro-activities in his mind (if nothing else, then just to scratch!). As he perseveres, the body would start experiencing solid stillness, which would imprint itself on the mind too, giving the practitioner a taste of a silent mind. Over time, as one gets used to this state of mental stillness, it tends to persist longer and longer off the mat. It is relatively easy to maintain this state in routine tasks that require little to no mental effort. With practice, it is possible do any and every activity within this state. This brings us back to the question, what is the defining characteristic of this practice? How can I cogitate with a silent mind? This latter question is to a moderately experienced practitioner what the question of difference between daydreaming and on-cushion shikantaza is to a beginner. This is where the concept of "Internal Posture" or "Poise of Consciousness" comes in.
When one starts practising shikantaza, one often starts with a riotous mind. What happens relatively soon is that the mind starts to split into two parts: the Doer and the Knower (to borrow from from Ajahn Brahm), or the Prakriti (Nature) and the Manomay Purush (the mental self). It is this Witness/Knower/Self part of the mind that one tends to carry over off the cushion for a while, before one loses consciousness of this state and immerses back into the Doer/Prakriti part again. (I am deliberately cutting out large swathes of metaphysical details as we can all debate them ad infinitum, and am including details only in as much as they facilitate actual practice.) Gradually, this Witness part can be strengthened to an imposing degree on a permanent basis. To quote Sri Aurobindo:
The substance of the mental being is still, so still that nothing disturbs it. If thoughts or activities come, they cross the mind as a flight of birds crosses the sky in a windless air. It passes, disturbs nothing, leaving no trace. Even if a thousand images or the most violent events pass across it, the calm stillness remains as if the very texture of the mind were a substance of eternal and indestructible peace. A mind that has achieved this calmness can begin to act, even intensely and powerfully, but it will keep its fundamental stillness – originating nothing from itself but receiving from Above and giving it a mental form without adding anything of its own, calmly, dispassionately, though with the joy of the Truth and the happy power and light of its passage.
Once this state develops, then the habitual activity in the outer part of the mind (the Doer) can be left to itself, with little to no impact upon one's progress, though it would be relatively easy to impose quietude upon this part once the essential freedom of the Witness has been attained. It is the "meta-awareness", or "awareness about your awareness". This fundamental state of Witness that remains unaltered off and on the cushion is the first experience of Poise of Consciousness or the Internal Posture. I say first, because once you know (by real-time experience) how to sit in your mind, you can do many more things than merely sit (though this is the most fundamental as well as the ultimate poise to learn). Everything you do in yoga with body and breath is to fundamentally prepare your outer instruments (the ones that are currently more amenable to direct manipulation) such that they experience the posture that you must truly experience in your consciousness, so that you experience it in your consciousness eventually. If you situate yourself adequately internally, then breath and body will follow the correct course naturally.
One thing I have personally experienced is: as one sits still, and perseveres through the strong impulses to move the body, a point comes when suddenly large chunks of "awareness" seem to get released from their habitual preoccupation with futile little indulgences in body and mind and conglomerate together into a dense mass. This often gives a feeling of a whirling fan across the length of the torso, with the mass/pressure building up either in the centre of the forehead, or a strong and peaceful opening above the head, as in a prayer, and sometimes a deep pressure in the heart centre. All "Silent Illumination" schools (whose motto may be, "You are the Buddha/Brahman") basically indicate the internal posture of Buddha/Brahman which you can assume right now, regardless of the obstacles in your physical and outer psychological nature or in the way you breathe. Once you assume that posture, the rest of the work will happen by itself. That makes for the simplicity and the difficulty of this process.
Magick is fundamentally the art of getting into the internal posture reflective of someone who already has the thing you intend to gain. This is also closely related to the true meaning of "Faith" – a will-cum-knowledge that persists against all outward appearances to the contrary. If you wish to be a leader, you must have the internal poise of a leader. Then the speech and action as would befit your natural leadership style would emerge naturally. Plenty of people imitate successful people in their outer habits and yet fail to experience any real success, simply because they fail to tap into the inner poise of these successful people whence such habits of action have emerged.
At deeper/higher levels, the distinction between stillness and activity starts disappearing. For example, in tantra, you can send an active force to effectuate something. Such a force can be countered by another force from someone opposing your intention. Alternatively, you can embrace the creation (or at least the situation) as part of yourself, and be poised in the adequate manner. This sets into motion a more impersonal and "directionless" silent will, which does not crush and sustain opposing and friendly factors respectively, but simply rearranges all factors such that even in opposing, one cannot help but create it. Since the action is "global" and directionless, there is, in a way, nothing one can counter/oppose.
True mastery of stillness forms the bedrock of strength and joy in activity as well as in passivity. Any lack thereof is a sign of pending progress. As the Isha Upanishad says:
Those who pursue Ignorance (the way of the Many), fall into darkness. And as if into a greater darkness fall those, who pursue Knowledge alone (the way of the One).
That is your koan for today. 🙂


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These cold winter days have me pining for a warm, comforting breakfast… Without tons of added sugar and butter. Anyone who has met me knows I want it all, in all aspects of my life. Why can't I have a warm, filling, and healthy breakfast? Oh, that's right, I can! These muffins prove it. So bake these up, eat them cold or warm them up, either way they are sure to satisfy your wintery sweet tooth and your grumbling tummy, without adding extra lbs to your waistline. So enjoy a batch of homemade healthy, without any guilt.
½ C quinoa flakes or rolled oats
¾ C protein powder
¼ C gluten free flour or preferred flour
½ Tsp salt
½ Tsp baking soda
2 large bananas
2 Tsp vanilla extract
½ C preferred milk
1/3 C sugar (I used brown)
½ C Chopped walnuts
Optional add ins:
¼ C Chocolate chips
¼ C blueberries
1. Preheat oven to 355 degrees.
2. Prepare muffin or cupcake pan with preferred oil or butter.
3. Mix all ingredients together, spoon into prepared pan.
4. Bake for 15-20 minutes, or until edges are starting to pull from the sides, allow to cool for a few minutes before serving.
Super easy & super healthy!


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