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Tagged: e3-2011 (x)
Hitman Absolution E3 2011 Behind Closed Doors +Audio Recording
By: goukijones Jun 20, 2011 | 5 Comments
Exclusive audio of Hitman Absolution at the E3 2011 Behind Closed Doors Demo. Including actual demo screen shots. Also my take on the gameplay and exclusive pictures from inside the private room. Nothing you haven't seen before.
The demo starts out with Agent 47 hiding in a corner of a "derelict Library." The room was crawling with about 10-15 cops. Get ready for this comparison a lot, it looked like Batman Arkham Asylum. Agent 47 sneaks around for a bit, the cover system locked onto the walls real well and hugged corners as he snuck away from cops. He also has "Detective Vision" where he can see kind of an outline where the cops are about to patrol. A line of fire draws along the ground where the cop is about to patrol.
You can listen to the actual demo I saw, in the video below. The video includes some screen shots of what I actually saw. Then as you read on, I'll describe my thoughts on the gameplay and you can check out my actual notes from the E3 2011 Hitman Absolution demonstration.
Actual Audio from the Hitman Absolution E3 2011 Private Demo
Agent 47 sneaks around killing the cops of one by one -all of their backs are conveniently turned- and nobody in the room is the wiser. Nothing you haven't seen before. In this room the developers manage to show you a lot of the moves and stuff that's in the game. Certainly a demonstration level. I'm a real gamer though, I know what's up. A lot of BS. The sequence ends with Agent 47 taking a rookie cop hostage and I might have blanked out a little at this part, that or my flask was blocking the screen while a took another drink. He grabs the rookie and then he's surrounded by all of the cops in the room. I thought the Detective in charge shot the rookie, just to get to Agent 47. I don't know, that would be crazy right? Do you know any cops that would just shoot another cop that easily when there are 40 cops in the room and 1 bad guy. Sorry, back to the demo.
A chase ensues up there stairs and there's a little shoot out. God mode heard. Agent 47 takes no damage and escapes. He conveniently walks into another room where a helicopter is waiting outside ready to shoot the place up. Nothing you haven't seen before. This was to demonstrates the destructible environments of the game, the loud sounds and Agent 47 sneaking around some more. When he makes it to the end of the hallway/building there's a cop there. No trouble here though, the cop is facing the opposite way and doesn't see Agent 47(or give a shit about the huge helicopter attack that just went down.) Agent 47 sneaks up on cop and chokes the shit out of him. Then he puts on the cops uniform as a disguise. He then walks right out onto the ledge where the chopper is like no problem. A little ridiculous if you ask me.
No cause for alarm from the helicopter, he must not have known there was a fellow officer on that top floor. Agent 47 causally walks across the roof top as the helicopter hovers over head. He sneaks into this stoners apartment where they are growing massive amounts of weed. One of the pot heads is so stoned he Agent 47 is just hilarious, just like this demo. Then some real cops bust into the room and Agent 47 takes them out with some hand to hand combat. Nothing you haven't seen before.
He walks out into the hallway and takes the elevator downstairs right into a mini police command center set up in this hotel lobby. The room was full of cops. The game slows down as you walk pass people and they seem to notice something about you. But nothing happened in this demo, just slow down. There's all these guns and grenades on the table and it looks like he can pick them up. I'm thinking okay big shoot out coming here. Nope. He picks up a donut instead just as another cop calls him out. Agent 47 has his back is to the cop and the cop thinks Agent 47 is somebody else and is just talking to him. Agent 47 never turns around and the cop eventually gets distracted and leaves. This entire time the screen said "Push X to put the donut down." I can only imagine that if he did put the donut down and turned around the cop would have realized Agent 47 was not who he thought he was and a big shoot out would have occurred. But nothing I saw in this entire demo led me to really believe something that cool would happen.
The demo ended and according to my actual notes while watching the play through below, I found it interesting. Although I believe this entire Demo was just set up for press, the game looked like it has potential. Hitman Absolution came off to me as a Batman Arkham Asylum clone. Nothing you haven't seen before.
My actual notes while I watched the demo live.
- There's a big slice in the middle of the demo TV
- Sweet cover and trail system
- Cops can't see him right in front of them
- Cover hangs on and turns corners
- Detective Vision
- Drakes action sequence
- Disguise system - cop
- Walks into crowd of a 100 people
- Interesting
Let me know if you are hype for Hitman Absolution. Hype it up in the catalog and then leave a comment on this story. Oh and Don't be a Jimmy ....
Transformers Universe MMO announcement party at E3 2011
By: BatRastered Jun 18, 2011 | 9 Comments
FnJimmy and BatRastered head to Hollywood to see what's up with the new Transformers MMO currently in development.
Team Gouki was invited to a party for the new Transformers MMO - Transformers Universe, to be launched some time in 2012. The party was at the same time as the Sony press conference, so GoukiJones couldn't attend. FnJimmy and I watched a stream of the Sony conference and showed up fashionably late to the party. We were told there was free booze.
FnJimmy hearts Optimus
Given that E3 takes place at the LACC right in the heart of downtown L.A., attending a party in Hollywood meant a $30 cab ride (each way). This meant we had to have a bunch of free booze and hors d'oeuvres to make up for the trip. FnJimmy of course wouldn't eat anything because it had ingredients, so I made sure he got his fill of cleverly named drinks (there was an Autobotini and I can't really remember any other names as I had a dozen gin and tonics). I, on the other hand dined on lamb meatballs, mushroom flatbread pizza, and feta cheese stuffed pastry.
Oh yeah, the game... Well we didn't see anything of the game except for a teaser of a generic robot and the "2012" date. You can see it in FnJimmy's video here (warning, drunken rambling ahead):
There was a station set up to make your own transformer, unfortunately the customizations were somewhat limited because only the first three items in each section were unlocked. This meant that there were only 24 possible different combinations to choose, so everyone's looked pretty similar. FnJimmy and I printed ours out on expensive photo paper anyway.
We didn't see anything like this...
We were entertained by the band "Black Cherry" from the UK. They were awesome, I even spent some time talking to them between sets. FnJimmy was hit on by an attractive British girl because of his shirt. No action taken on his part. I don't actually remember this, so it's a good thing I tweeted it to remind me later. Here's another random tweet of the location, outside.
Another random picture we didn't see...
After we'd had enough (which is to say, the band was done playing and the food was done being served) we finished our last drinks and headed back to the hotel, ready to kick off E3 with a massive hangover. Good thing we got some real breakfast the next day and not an egg salad sandwich... JIMMY!
WTF This Game Centipede Infestation
By: fnjimmy Jun 18, 2011 | 6 Comments
Yes this is a real game for the Wii. Watch the video over my shoulder. It's ridiculous and absurd. I will never play this game again in my life.
I really don't have more to say about this game. The video will for sure speak for itself. Flush it!
E3 2011 Centipede Infestation FnJimmy's official take
Team Gouki Exclusive Full Hands On with Skullgirls E3 2011
By: goukijones Jun 17, 2011 | 6 Comments
Team Gouki visited with Reverge Labs/Autumn Games at E3 2011 to see Skullgirls. An independent 2D fighter with great ambition. Now picked up by Konami - A new challenger has entered! Check out our exlcusive coverage.
Skullgirls was on my schedule as the last thing on the final day of E3. I knew I had one of the best things saved for last and I couldn't wait to actually see this game in person. But a whole 28 hour period before I stopped by this little corner in the Konami booth, FnJimmy and BatRastered played Skullgirls. Here's FnJimmy's official take, moments after playing Skullgirls for the very first time ever.
FnJimmy's Official Take from E3 2011
Then I finally rolled up the following day a little early for my last appointment. Also spending all that time before hand in the Square booth, depleted my flask and totally had me in the mood for a fighting game. I was greeted by Alex and he was cool. He knew about the game enough and was constantly taking notes. I was then introduced to Ian Cox a designer at Reverge Labs. He interrupted two Jimmys that were playing on 1 of the 2 Skullgirls set ups in the Konami booth, kicked them off. Then Ian and I stepped up to play. You notice badass nice custom fight sticks, completely decked out with the Skullgirls. They were from Arcade in a box. Check out this picture I snapped while they we're packing up.
So we began to play. We did 3V3. First cool thing about Skullgirls is you can do 3V3 2V2 1V1 OR 1V2 1V3 2V3 and the scales adjust your health and damage, depending on how many are on your team. The game looks amazing, I'm not going to even talk about that. Check out this Off Screen footage I captured while FnJimmy and BatRastered played again.
E3 2011 Skullgirls Off Screen
Skullgirls has a classic Street Fighter 6 button control setup and fighting style. Add in the MvC style swapping plus super chains and you got some craziness on your hands. Only 3 characters were playable at the show. I played with Cerebella most of the time, she's a grappler, like Zangief. Like how FnJimmy likes his women. Another cool innovation in Skullgirls is the non jumping 360. Ian explained, if you hit bottom 5 points of the fight stick while circling for a 360 motion, the character will lock to the ground and not jump. I thought that was very smart. There's tech throws and something like a alpha counter/snap back, but more on that later. Skullgirls has a ton of depth to it.
Ian would show me chain combos and it reminded me a lot of Street Fighter 3 style button chains. Nothing crazy and out of control fast like MvC3. The pace of the game looked well balanced, but I didn't really get to see any of the mixed size team matches. That's also an interesting idea.
All in all this is something to get hype for. It's coming to XBLA and PSN, so it's not going to be more than $20 hopefully around $15. At $15 I strongly encourage fighting game fans to give this game a try. This is gonna be in competition at EVO 2012. Don't be a Jimmy!
Community News
What at E3 got me hyped? More info on new SSX
By: iorilamia Jun 17, 2011 | 5 Comments
E3 was cool but much didn't blow me away. What really got me wide-eyed was more info on one of my favorite franchises , the SSX series.
SSX is the Tony Hawk of Snowboarding games and has always been incredibly fun. Initially I was hyped when the new SSX: Deadly Decents was announced but a bit worried. The short trailer didn't have the same ridiculous over-the-top fun flare SSX fans are used to. Instead it had a more serious look. Luckily with the information slowly coming out of the blogs and what was shown at E3 has put a big smile on my face.
Deadly decents does look a bit more armored but the movements and gameplay still has a awesome SSX feel. What they added to the game which is a big step ahead is that they have been using maping data from NASA. "Mountain Man" takes actual lattitude and longitude data to mimic real-life mountains. Also they made a great choice by picking obscure mountains. Instead of picking the big famous ones people always go to (Like Aspen and Taho) they went big and got places in Siberia, Alaska , Himelayas and much more.
The 3 major game modes are Racing, Trick-it and Surviving. Self explanatory especially if you have played the older games. Racing is whoever gets down the mountain fastest, Trick-it is the gory of SSX, doing ridiculous flips and combos for points and surviving is surviving the mountain, avalanches and catastrophes galore.
What was interesting was they changed the control scheme a bit while keeping the old one. The old control sceme with button combinations is still intact, but they also have similiar controls from games like Skate, where you flick the thumb-stick for combos. That sounds super badass , I may be using a combo of both.
The guy also spoke about what "Deadly Decents" really is. Kind of like a boss battle? Not only do you survive through riding the mountin but theres other stuff besides riding a snowboard. Apparently there will be some survivor-man climbing and hiking type stuff. Not too clear on it really >_<
Watching the gameplay really was the best though, seeing the game and being able to tell it is going to have some of the same flare should keep every fan happy.
So SSX fans, how does all of this sound to you? Let us know in comments and check the link below for the video interview.
Video interview : http://blog.us.playstation.com/2011/06/16/e3-replay-ssx-on-ps3/
BONUS AWESOME NEWS! My two favorite characters from the SSX series have been confirmed for Deadly Decents. Mobi and Kaori! <3333333
Hands on with Gears of War 3's new horde mode at E3 2011
By: BatRastered Jun 16, 2011 | 6 Comments
Team Gouki got a chance to play the new and improved GoW3 horde mode at Microsoft's E3 2011 booth. -Updated- FnJimmy's official take on horde mode video
E3 day 3, FnJimmy and I bolted at the opening striaght to the Gears of War demo. As we were standing in line, the Microsoft guys were passing around these giant cards of what to expect in the new Horde mode.
Check out FnJimmy's quick iPhone grab of the card:
If you can't read that (good luck) here's what we saw and played...
You start off by selecting an area to defend, we started in the hotel lobby. There are a bunch of glowing spots where you can set up fortifications such as barbed wire, turrets, and decoys. These slow down or even take out Locust as they try to make their way into the lobby, making them easy pickings for you. These fortifications aren't free, however. You need cash to set them up. You start off with a limited amount of cash, but you rack it up by killing enemies and completing any bonus objectives that pop up (these will require you to leave the relative safety of the fortified area usually, so watch out). In between rounds, you can purchase new fortifications, repair old ones, and get new weapons. Every 10th round is a boss wave... we had to fight this thing.
Unfortunately, you can't just lay down fortifications where you want, Gears has spots chosen for you. It's ok, but I expected a little better from the game that started this horde mode craze. Still, it's a lot of fun to build up your defenses and rail a bunch of Locust, especially when the big baddies come along.
We still haven't got a chance to see the campaign yet, but we did see the new limited edition Xbox 360 (with custom sounds!). Check this bad boy out...
Yeah... that's pretty sweet. I think it looks better than the Halo Reach edition. (We here at Gouki.com are especially fond of the red & black color scheme.)
Gears of War 3 and the Limited edition GoW3 console release Sep 20, 2011
The Legend of Zelda Skyward Sword E3 2011 hands on impressions
By: BatRastered Jun 14, 2011 | 7 Comments
Pro gamer FnJimmy goes hands-on with Skyward Sword in the Nintendo booth. Watch as he destroys the first demo and has time for another.
FnJimmy and I headed to the Nintendo booth to play some Zelda Skyward Sword. You can choose the bird riding level, a dungeon level, or a boss battle. They only give you a 10 minute demo to keep the lines moving and FnJimmy had played a little bit of the combat last year, so I encouraged him to take on the bird riding.
Most of the people in front of us had tried the bird riding too, none of them seemed able to beat it in the 10 minutes allowed. Noobs... give that Wii mote to FnJimmy and watch him do his best Fred Savage from that one movie from the 80's...
Uhhh... No, the other one...
That's better
Yeah, he may be a n00b at FPS games, but FnJimmy was born with a Nintendo controller in his hand. Okay... back to reality... Watch FnJimmy rail the birds so fast he still has time to do the dungeon level. "Good job, Jimmy!"
FnJimmy had a huge grin on his face after that and wouldn't let us leave the Nintendo booth until I had recorded his takes. So here is the offical FnJimmy hands-on impressions of The Legend of Zelda Skyward Sword.
The Legend of Zelda Skyward Sword releases this holiday season for the Nintendo Wii.
Gotham City Impostors E3 2011 hands on
By: BatRastered Jun 12, 2011 | 7 Comments
Team Gouki had a chance to play Gotham City Impostors at the Warner Bros. booth at E3 2011.
FnJimmy and I had finished playing some Arkham City and were lured into the depths of the Warner Brothers booth by this fantastic booth babe. FnJimmy has some NSFW photos from another angle I think. She's the official BatRastered booth babe of the year for staying in character and talking smack.Read full story...
WWE '12 Secrets Revealed - Gameplay & Interview [E3 Exclusive]
By: goukijones Jun 12, 2011 | 5 Comments
Exclusive Gameplay footage and interview. Gouki.com wanted to tell THQ everything about what we do with SmackDown VS Raw 2011. We've got a helluva story to tell from inside the THQ booth at E3 2011 with Dev Talk about WWE '12.
Anybody that has checked out Gouki.com certainly knows we are big fans of SmackDown VS Raw and just huge wrestling fans over all. We've successfully recreated each WWE Pay-Per-View since Survivor Series 2010 with WWE SmackDown VS Raw 2011. We have simulated over 60 matches, something we refer to as the Madden Bowl of wrestling. We film the matches before the PPV and both wrestlers are AI controlled. We have downloaded, created and edited over 100 Superstars and Divas in the game.
We know what want in WWE '12 to make that aspect of the game for us even more enjoyable. Personally I say, watching the simulated matches are sometimes just as good as watching the actual live match.
Here's what happened. I had just finished my Konami "Booth Tour" with some Canadian chick with a bunch of FAQ sheets. More on that in another story. I believe BatRastered and FnJimmy we finishing up watching Aliens. I stormed the THQ booth looking to meet people I knew actually did shit there. Neal Pabon, I talked to that guy, what up to him. The press/media counter don't give a shit about nobody without an appointment. There were no goodies and the lady gave me a business card with an FTP for their media kit, when I had just saw her hand some Jimmy the full on disc version press kit.
I stumbled back over to the WWE '12 wall to see if BatRastered and FnJimmy had arrived yet. I took a drink out the flask while less people were looking and just started to play WWE '12. The first guy that came up to me didn't seem to know much of the game. When I told him what we did with it, he didn't seem to understand or maybe he didn't care. I fucked off and tried to talk to more Jimmys in suits. I couldn't find the nuab who I suspect does the Twitter account. He's given me a few shout outs and I just wanted to say thanks. No success.
Back to the WWE '12 section where I scouted out the other possible dev working the section. At E3 you really have to dig deep and ask questions, most of the time you could just be playing with a random PR guy hired that week to demo a product for you based on a script. I definitely did not want that to happen with WWE'12, I wanted to talk to somebody seriously and share my experiences with the game and offer 1 or 2 of my 100 plus suggestions. That's when I met Jason Vandiver, his business card is official and it says Designer on it.
Jason knew what was up with the game and understood what we did with it. [Spoiler Alert] I may say things that I wasn't supposed to talk about. I hope Jason doesn't get in trouble. [/Spoiler Alert]
Jason told me that there would be 2 new create a "Something." I know, not much to go on. SDvR2011 already has a lot of create a "something." FnJimmy says it could be the create a belt. I disagree, I believe one will be something like create a show. My thought is I would love to just program 6-7 matches in a row and then just watch them as the AI played it out. You can kinda set that up now, but an easier way is needed. Create a backstage promo or something, I don't know man, the game does a lot already.
Then we played a match, I chose Albero Del Rio and he drove out on stage in a fancy car. Just like the Eddie Guerrero intro FnJimmy has attached to him in our simulations. It all looked great. Jason chose Randy Orton. I don't know how to play the game and I don't know if he thought I was full of shit at this point, but I had no clue what to do with the actual controller. I just watch this game. So he beat the shit out of me and showed me one of the coolest new features.
Super wake ups. A super wake up for example is when your oppenet is on the ground, but needs to be standing for you to do your finisher. Jason leans forward and shouts "Watch this!" The game cuts away into a taunt animation and Randy Orton slams to the ground and throws his little temper tantrum. AlBerto Del Rio who is still knocked out cold in the center of the ring, shoots to his feet and Randy Orton stands up and RKO's him. Awesome. Very smooth, going to make the end of matches way more exciting.
Jason wasn't done, he picks Alberto Del Rio up again and starts beating on him and building his super bar again. This time he showed me Randy Orton's punt. I said "Something that I'd like to see is that when you select end a match with a finisher that the AI still pins, like in WWE All Stars." Jason said not to worry that was added.
BatRastered and FnJimmy finally had arrived. I pulled FnJimmy to the side and had him play the game while I filmed this off screen footage. Now THQ probably don't want me to play this, but I don't have any other gameplay footage. Both press kits I checked only had the live action Randy Orton trailer. You can see Vintage SDvR2011 AI in this clip where Randy Orton sets up Alberto Del Rio for an announcer table smash, but the Randy Orton can't grab on to do the move and, you know what, I'm not even sure which one FnJimmy was controlling. Just watch the clip.
You can hear the guy at the end of the video offer me some HD footage on a disc, it wasn't there sorry brotha. Send me some and I want another interview. Thanks.
After that part we busted out the official Gouki.com microphone and FnJimmy did his first ever official interview. With himself. Check it out.
We wrapped it up and got four amazing contacts. We love this game franchise, SDvR series is a game that makes sense to come out every year.
Thanks to Jason
Thanks to Narbeh
Thanks to Cory Ledesma
Thanks to Neal Pabon and thanks to everybody at THQ.
Leave your comments below Jimmys. Thanks for reading and watching Gouki.com!
Aliens: Colonial Marines E3 2011 demo impressions
By: BatRastered Jun 11, 2011 | 8 Comments
The Gouki team paid a visit to Sega's booth at E3 2011 for a first look at Aliens: Colonial Marines in action.
Hot on the heels of the first official trailer for this game, Sega let us in to see an early build of Aliens: Colonial Marines being played by the Gearbox staff and hosted by non other than Randy Pitchford, CEO of Gearbox Software.
When asked when the game takes place in the Alien universe, Pitchford stated that he considers this the "true sequel to Aliens", which brought cheers from those assembled for this demo. We soon found ourselves in Hadley's Hope searching for survivors and clues as to what happened during the events of the Aliens movie. The level of detail even in this early build was quite impressive. Fans will clearly recognize the blueprints of the building and the labs housing the face-suckers. Things quickly turn dark for our band of marines as the sounds coming from the motion tracker become more urgent. Alien xenomorphs soon begin emerging from the ceiling air vents, taking many of your squadmates out in the process. The aliens move all along the ceiling and walls as easily as the floors, and they move quickly. You will really need to have your head on a swivel if you wish to keep it attached in this game! Better yet, bring some backup; Aliens: Colonial Marines supports 4 player co-op. As Pitchford announced this feature, a second Gearbox employee joined the demo. Much like Gearbox's recent hit, Borderlands, the additional player simply popped into existence and a message appeared on the screen stating that "player 2 had joined your party". Nothing was mentioned of this, but I noticed that the second player had some custom looking artwork on their armour hinting perhaps and some level of player customization.
Most of the action was standard FPS stuff, move from point A to point B and have a firefight, but along the way the engine showed off some survival horror effects (exploding lights, face-suckers throwing themselves at the inside of their glass cage towards you with the accompanying music queue) and other events like random marines being gruesomely dealt with by the aliens. We weren't shown any items other than the motion scanner, but we did get to see a few weapons including the pulse rifle and sentry turret.
Seal the door!
After the marines had decided to take a last stand, a giant firefight broke out, culminating in the alien queen bashing through the door and ending the demo with an ominous fade to black.
For those worried that an Aliens game can't live up to the hype, let me tell you that Pitchford and his Gearbox staff were visibly excited to be making this game, and very much knew their stuff about the Aliens universe. Pitchford was shouting out movie quotes throughout the demo, and mentioned that they had the chance to work with many people and assets from the film.
In addition a version of the game will make its way to the WiiU after its launch. While we don't know specifics on the WiiU version, it is easy to imagine a motion tracker on the controller screen. Pitchford would only say that Gearbox was proud to be one of the early recipients of the developer kit for the WiiU.
Aliens: Colonial Marines ships out Spring 2012 for the Xbox 360, PS3 and PC.
XCOM Behind Closed Doors [E3 2011 Exclusive]
By: goukijones Jun 11, 2011 | 4 Comments
Exclusive Pictures from behind closed doors. Gouki.com got the world famous treatment from 2K Games at E3 2011 and one of the games I saw demod live right in my face was XCOM. Completely different from last year. This is my new Brink!
I certainly had the privilege to see XCOM in the 2K booth this year at E3. Last year XCOM was a FPS action game, that looked like it didn't have much to offer. This year, what I saw was a completely different game. My session was hosted by a developer or producer of the game, I can't remember his name, I nubbed it up and didn't write it down or get a card from him. He reminded of Kramer, from Seinfeld. He was great. I understand that knowing his name would have helped out a lot more with this next quote.
"The game is now a lot more like Final Fantasy Tactics" He explained in reference to the party system.
I spoke to -again I can't find his name, I apologize- He told me the game may even let you send out your party to do side missions and they will level up and bring back stuff like in Final Fantasy Tactics. My mind was blown.
During the actual playable demo, that a developer was playing behind him on the Xbox 360. They showed a lot combat and explained how the looting of the aliens worked. XCOM is squad based now and very strategic, this aspect shown, reminded me of Mass Effect. You could hack alien tech and use it against them. Some alien tech completely blew buildings apart while playing. If you don't use alien tech right away in combat, you can take it back to the lab for more long term benefits. These were all very cool ideas that I was hearing. The game now has a release date of March 6th 2012, so this is the new official GoukiJones hype game. Don't worry XCOM will not be another Brink.
These are my actual notes while I watched the live demo:
- Different demo from last year
- RPG agent elements added
- Similar to FFTactics party
- Team setup and choose the mission
- Aliens look way cooler. Humanoid
- Squad controls
- Capture enemies and use the powers now or later
- Xbox Demo
- All Aliens can be tech
- Complete 180
This is your base, where you suit your guys up and level up their gear.
Read full story...
Batman Arkham City Railed with Hands-on [E3 2011 Exclusive]
By: fnjimmy Jun 11, 2011 | 6 Comments
Batman Arkham City is going to be amazing. Catwoman gameplay is it own unique style. I can't wait to play the full on version.
I can't say much. What can I say? This is my take right after I played Batman Arkham City at E3 2011 last Wednesday.
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text:
The Abbot's Notebook for June 20, 2018
My sisters and brothers in Christ,
Blessings to you! Prior Benedict and I are still in New York. I return to Christ in the Desert tomorrow and he returns on Saturday. We came here last Friday in order to have some meetings and to visit some benefactors.
The day that we left to come to New York and Connecticut, Brother Dominic returned from India with a new candidate for our community, Father Subin Thomas.
Four of our brothers attended the ordination of several permanent deacons for our archdiocese this last Saturday and stayed overnight to continue with the celebrations on Sunday. Father Mayeul, Brother Antoine, Brother John Paul, Brother James and Brother Augustine all returned Sunday night to the monastery.
While in Connecticut, Prior Benedict and I spent a couple of days at the Abbey of Regina Laudis. I had visited here once before, but just for a couple of hours. This is a strong community of Benedictine nuns. When I see all that they have done, sometimes I believe that they are much stronger than we are. They have their farm, they produce cheese and fruits and grapes. They work when the weather is hot and humid. They sing the full Divine Office according to the Rule of Saint Benedict, and in Latin. They have many highly educated nuns. It is truly an impressive community. When I visit communities and find a thriving, vibrant community with strong monastic observance, I am always impressed!
Many know that we are once again helping Saint Benedict's Abbey in Polokwane, South Africa. They have had a sort of meltdown and are struggling, especially financially. They are now working on seeking ways to recover financially and to go forward. This small community of monks has had various setbacks over many decades. This is our second time to walk with them and to help them move forward. We walked with them from 2006 until 2011. At that point our Abbot President of that time wanted a different superior and we withdrew, even though we still had one monk there. After another six years, we have gone back to work again. Christ in the Desert helps several communities financially at this time and so far, God always sends us the capacity to help these communities and to continue forward. Sometimes I let our own benefactors know that the help they give us helps also many other communities today.
One aspect of our spiritual life is always to help when possible and sometimes try to help when it seems impossible, trusting in Divine Providence. What is this Divine Providence? It is a simple awareness that everything, absolutely everything, is in some mysterious way in the hands of a God who loves us and watches over us with love. It is Divine Providence that has brought about the Monastery of Christ in the Desert and allowed us to flourish at this time and to help others. It is Divine Providence at work in the life of each monk that has brought us to Christ in the Desert and has allowed us to live in relatively deep peace and harmony (with occasional clashes!). It is Divine Providence that always gives our monastery enough resources to continue and to help others.
I try always to be careful in using well what is given to us, but without becoming overly scrupulous. It is foolish to waste the gifts of God and yet God so often lavishes His gifts upon us, perhaps foolishly to show how much He loves us. So often in the life at Christ in the Desert, when we are down to practically no resources, God has placed before us the challenge to give away what we have and trust in Him. For me, at times, it would be much easier to hold onto what we have with a fear about the future. Instead, God seems always to test my trust in Him. I have to let go and give away freely, when there is truly a need, and trust that God will continue to send us all that we really need.
Sometimes I think that God has made me foolish. At other times I see the absolutely generosity to our community and know that God has blessed us with so much that we must share it with others. There are times when I can see so clearly how foolish God is with me and with others—foolish in the sense of giving everything to me and asking me to trust Him when He asks me to give away all that He has given me.
Part of living is learning wisdom from the Scriptures. Wisdom is not about academic understanding or even about logic—although wisdom does not exclude academic understanding and logic. Wisdom is the art of living well and living for God. So if God asks me to give away everything, and it is really God asking me, then I must give away all and trust that God will give me in turn all that is necessary. Wisdom is knowing that God is present always and loving and caring for me. Even when I make bad decision and mess things up, God is present and working to make things right for me and for all others. Wisdom allows me to trust completely, to do the best I can even when it seems not enough.
Wisdom is together with Divine Providence. Wisdom is a gift to us and Divine Providence is God's abiding presence with us, always working for our good. There is so much to be grateful for in this life, if we open our hearts and our minds in faith to God's abiding presence.
As always, I will offer a Holy Mass this week for you and for your intentions. I ask your prayers for me and for the women and men of our communities. And I send you my love and prayers.
Your brother in the Lord,
Abbot Philip


text:
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text:
Media is saying that using IP technology CIA has managed to track down not just the exact building the DNC hack came from, but also the office, terminal and identity of the hacker.
He is of course, Russian.
Media is saying that using IP technology CIA has managed to track down not just the exact building the DNC hack came from, but also the office, terminal and identity of the hacker.
He is of course, Russian.
I literally just got cancer from that webm
this entire board is mostly conservative.
we don't buy into the mainstream media narrative anymore.
you can even take DNA sample and test whether they are true ethnic Russian and not just Chinese hacker employed by Russians, cuz you know, they are the bad guys
f*****ck d*rum**pf
>>>Holla Forums
>>>Holla Forums
How can you even be a Holla Forumsie while at the same time being a disgusting communist?
>>>Holla Forums
I am class aware, that's why I hate jews.
>>>Holla Forums
Fuck off.
Some expert on "smart blockchain" had proofs of Russian hackers influencing American elections by collecting IP addresses of the public wifi near the Kaspersky office in the Netherlands.
Anti-establishment would be more appropriate to call it
Well the establishment IS far left wing....
Yet trump is in office
Trump is centre left, moron. He's a New York style democrat, you just think he's right wing because he thinks borders are a good idea.
It isn't as ridiculous as the nork hackers but it's still pretty stupid to just assume it was a foreign agent (who'd be more likely to use the proof of wrongdoing as a trading chip) instead of an internal leaker.
But user they aren't neo-anarcho-marxist-bolshevik-trans-negroid-feminist-syndicalists, the only true form of gay space communism.
The Russians are going to be blamed for ==EVERYTHING== now for fuck sake IP can be falsified like hell if they have the ressources, if it really was Russians if would be some BS IP like france or UK.
Also for some fucking reason their an enormous amount of slander and fake news coming from officials and "journalist" in a lot of European countries since muh Russian hacker it's like they try to start war or make them look like the bad guys.
Honestly if people want to look at the bad guy's look at fucking china and communists in general.
I see they are still pushing the evil communist Russia narrative, and why wouldn't they the masses are easily manipulated.
Nobody here is a conservative because modern conservatives are weasels
How am I supposed to trust what you're saying when you don't even know your left from your right?
Despite all presented evidence, I have trouble squaring the circle of invincible Russian state hackers with past experience of the only time Russian state hackers managed to hack anyone, police had to raid the office, seize server, take hard disks out and bring them to said hackers to copy the files.
Also according to some rumors, Putin's personal dacha's security system is operated by "if ((time1)) start_system();"-tier of code.
>if ((time4)) start_system();
Meanwhile, actual ex-CIA and ex-NSA officials demonstrate it was physically impossible for the DNC servers to have been hacked across the Atlantic:
Whom to trust? Whistleblowers or current employees of an organization that has lied to the American public for the entirety of its existence? Neither! No need for trust here, just follow the arguments and basic physics.
Are you retarded? The rusmutt was actually working for the DNC itself. Says so right in the article.
What a tweest. I'm sure the CIA has plenty of convincing proof for this timely revelation.
That's ju-jitsu. Kid needs to learn who is boss if he is to make anything of himself.
the establishment is liberals and neoliberals, idiot
tech is full of retards and extremists, which is why it is more fun than the establishment
fuck centerists, red-yellow-brown-black alliance for hackers is the only path forward
This isn't a left-vs-right issue, it's Democrats alongside Republicans being neocons to keep their MIC sponsors in embezzlementbux. Don't write off any of your normalfag acquaintances and let them swallow this poison pill:
First off, Guccifer 2.0 was a secondary redistribution point for NGP-VAN, not the original source of data from the DNC, which evidence suggests was probably an internal leak. Second, Guccifer 2.0 probably wasn't Wikileaks' source, and may in fact even be a DNC counter-op to taint Wikileaks' intel:
Holla Forums is a russian board.
The password to the DNC servers was, drum roll....
No fucking joke.
try me
putin is not a commie
How do you know this?
Because I was the russian hacker
I wish I could be like Alexander Dugin when I'm older.
Is this a serious post? Do you think right and left in that image refers to physical position?
And I'm sure the CIA just wants us to take their word for it, of course because muh seekrits
You're already a Jew, so you're half way there. :^)
populist rednecks would be a more appropriate label
le 56% master race everyone
top tier political expertise
all the cancer on this board identifies themselves with 1 of 2 political parties in the US
because Holla Forums is about technology, not politics. if you are here only to complain about the SJW shit in the western tech sector, you're not Holla Forums
Amerimutts are too mongrelized to understand context, so they use Ben Garrison-tier labeling on all their memes.
Good goyim, keep fighting among yourselves.
I asked that because technology is a polar opposite of socialism.
Come on now.
They hacked it through a Visual Basic GUI
I'm not American, I'm just pointing out that the bird of paradise lands only on the hand which does not grasp.
imagine my shock


text: Infographics are everywhere. Some good - some bad. But most creators don't stop to think how to make sure search engines can understand their infographic - or how people who can't see pictures can consume them (maybe because they rely on screen readers or have chosen not to download images to their mobile phone). You should definitely be using canonical URLs with keywords and a relevant directory structure that also includes keywords. You should also avoid using too many page variables after the URL. An SEO strategy that builds your website's relevancy and authority in the desired geographic area will ensure the site will be visible for a variety of search phrases. This increases the number of opportunities for your website to be seen among results. The blog posts that we build links to ranked very well and drove a ton of traffic for clients.


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If ever there was a poem appropriate to the day, it's this one ... I think I'll be shoveling for days ...
Shoveling Snow
by Kirsten Dierking
If day after day I was caught inside
this muffle and hush
I would notice how birches
move with a lovely hum of spirits,
how falling snow is a privacy
warm as the space for sleeping,
how radiant snow is a dream
like leaving behind the body
and rising into that luminous place
where sometimes you meet
the people you've lost. How
silver branches scrawl their names
in tangled script against the white.
How the curves and cheekbones
of all my loved ones appear
in the polished marble of drifts.
Have a good day, and if you're shoveling snow, do it carefully. More thoughts tomorrow when Musical Monday warms us up with some vintage Sam Cooke. Be here!


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I have decided to give the stem cell enriched fat transfer breast augmentation procedure a try. We were actually able to work it out with the clinic to do an interview with a local news station about the procedure. They were very interested to host a story on "natural" breast enhancement. I have a pre-op appointment before that for measurements, prescriptions and a rundown of events to come.
I was told I would need to gain a couple pounds (5-10) so I've been pushing my diet aside and eating what I want (fun to a point, it's hard to see the scale creep back up again, though!).
My thought process behind the decision was honestly, what have I got to lose? From my research the risks are VERY minimal, unlike with implants. The recovery time is also pretty reasonable from what I've read due to the type of lipo used (Vaser) and the fact that size is achieved through injection, not through surgical implants.
I've never liked the size or shape of the "girls", and this is an opportunity to do something about it without being "fake" or risking a lot.
If it makes me feel better about myself, then why not? Right? And if it doesn't work I'm only out some money.
Stay tuned!
**Please note that subsequent blog posts may be time-delayed**


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How To Find The Best Martial Art in the World
There are those who believe the best martial art is from Asia. Asia is revered for martial arts with great styles and systems originating in China, Japan, Korea, Philippines, Thailand and others. It may also be argued that the best martial art known today is Gracie Brazilian Ju Jitsu.
However, the truth is that no particular martial art is superior. As my teacher Danny Inosanto once said to me; "Bruce Lee would have been Bruce Lee regardless of what martial art he practiced." Most of my teachers believe it is not the art that is superior, rather it is the person. Each art has its strengths and weaknesses, although few martial artists like to acknowledge the weaknesses of their art. The weakness and strength of a martial art can be seen at the various distances between combatants. When it comes to hand distance, Western boxing has made short work of many martial artists. At kicking distance, who can dispute the power and effectiveness of Muay Thai? On the ground few arts are as devastating as Brazilian Ju Jitsu. Some arts fare better in close and others at a distance. However, in my 40 years of martial arts practice, I have not seen an art that was superior in every way to other arts.
I have however, seen martial artists that were superior to most others. I no longer follow the latest fighters, but for those of you who are a little older, let me remind you of several fighters from different systems. Bruce Lee, Dan Inosanto, Gracie Brothers, Joe Lewis, Mike Stone, Benny the Jet, Bill Wallace, Chuck Norris, Tony Ja, and Ed Parker to name just a few. I can make a list as long as you like, and you will find on my list, men of various styles, but all with superior ability. Can you tell me that it was the style they practiced that made them champions? Champions possess superior qualities; this is what makes them champions. A style is the compilation and implementation of ideas. It is a vehicle for the martial artist to carry out particular techniques, motions and movements. Perfection of a particular art does not in itself produce champions. In my humble opinion, there is no superior style, there are only superior men.
To View My Other Articles: Dirt To Dollars
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by Karl Bode, vice.com, 14 June 2019
5G is not magic, and experts say the wireless technology is not likely to revolutionize hospitals.
|Screengrab: YouTube/Verizon
To hear wireless carriers tell it, fifth-generation (5G) wireless is going to revolutionize the planet by fueling the rise of smart cars, smarter cities, and countless innovative new technologies.
While 5G will deliver faster and better mobile networks, however, experts say that most of the ultra-futuristic benefits of 5G have been absurdly overhyped by wireless carriers.


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AudioFBI This Week -- April 11, 2019 --The FBI commemorates National Crime Victims' Rights Week by recognizing all victims—including members of the Bureau family who died responding to the September 11 terror attacks or as a result of 9/11-related illnesses.
Audio Transcript
Mollie Halpern: The FBI provides information, support, and other assistance to victims of crimes it investigates through its Victim Services Division.
FBI employee William "Homer" Lewis died in the line of duty earlier this month as a direct result of his work at the Pentagon.
Homer is the 16th FBI employee to lose his life to a 9/11-related illness. Dozens more are sick.
FBI Deputy Director David Bowdich says the lasting impacts of the terror attacks are becoming more apparent every day.
David Bowdich: Many of our own have been impacted with rare forms of cancer. We've lost some of our best, and we're acutely aware of the many others who are ill and who may fall ill in the future.
Halpern: The FBI encourages its law enforcement partners, emergency personnel, and volunteers who responded to 9/11 or assisted with the recovery efforts to register for federal bAudioenefits.
This also includes those who worked, lived, or attended school in the New York City disaster area on the day of the attacks and the months that followed.
Learn more about the 9/11 health crisis and victims' rights at fbi.gov.
With FBI, This Week, I'm Mollie Halpern of the Bureau.
Listen to Audio


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Mosaic Making
We are starting an exciting mosaic project this week. As we plan our projects, we will ask students to bring in a dozen (or more!) items that could be incorporated in a mosaic. These could be bottle caps, coins, flat stones, pieces of sea glass, chunks of stoneware, glass beads, metal nuts, washers, tiles, or anything else that could be incorporated into a small mosaic tile. These will be pooled and made available to all children - special treasures that your child doesn't want to part with should be kept separate.
Are you interested in helping out with this project on Tuesday afternoons? We would love an extra pair of hands this Tuesday and next Tuesday (the 16th and 23rd).
Salmon Egg Delivery - Volunteer Needed
We need a volunteer who can go to the ODFW office in Springfield on the morning of October 23 to pick up our salmon eggs, then deliver them to us at Ridgeline. Join us in welcoming them into the home where they'll hatch and begin their long journey to the sea.
Thank you to Matt Peterson for picking up the aquarium equipment and to Lindsay Ramsey for setting it up!
Fire and Earthquake Safety
On Wednesday, firefighters will visit Ridgeline. We'll talk about fire safety and learn about firefighting equipment. On Thursday, we will join in the Great Oregon ShakeOut, a statewide earthquake drill. Be ready to talk about your family's plans in the event of a disaster.
Curriculum Sharing
What is the work of a Montessori student? Come see first hand at Curriculum Sharing on October 24th from 3:05 - 4:05 or 6:00 - 7:00. Your child will show you what they've been working on, and maybe even give YOU a lesson!
You may have noticed that this year you are receiving a lot more communication regarding the importance of regular attendance. This year we are beginning an attendance awareness campaign designed to increase awareness, educate, and ultimately improve student attendance at Ridgeline. Good attendance is strongly linked to academic, social, and emotional success.
We believe that students and families that feel they are included in the school community are more likely to show up consistently.
We believe that good attendance will allow your child to fully contribute to and fully benefit from the classroom community.
We believe good attendance will not only build strong academics but also build strong socially and emotionally capable humans.
Thank you for learning and growing with us!


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Where parties come alive!
We are family owned and operated and have been serving many areas of DFW for seven years.
Arlington, Mansfield, Grand Prairie, Burleson, Venus, Parts of Fort Worth, HEB, Midlothian, Crowley, Rendon, North Richland Hills, Irving. If you don't see your city mentioned please call and we can verify for you!
Our BIG BLUE water slide is our most popular water slide rental. It's fun for all and will keep you kids busy. Plus tucker them out for a good nights sleep!
Measurements: 13'W x 16' H x 39' L
The LARGE COMBO water slide is the best of both worlds. It has a 13' x 13' house house with a basketball hoop inside . Comes equipped with a TWO lane slide for hours of fun!
Measurements: 13'W 12' H x 35' L


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Oct 31, 2015
Steve hates Halloween, it drags on forever! Janet always promises a little something for helping out, but it never pays off. Plus, he hates answering the door! Then we find out Big Steve was confiscated for disrupting Barack Obama's senate election party!
Oct 24, 2015
On this 1986 grab bag, Classic Chet Chitchat, Garry stopped for Jay walking, Richard Lewis & Garry Shandling. Calling Johnny B before Bears/Packers game. The Year Of The Cat, Plus Bears Tim Wrightman & Tom Dreesen, & a young Pat Dahl checks in.
Oct 17, 2015
Steve & Garry are broadcasting in San Diego at the Sheraton Harlan Island Hotel, for the 1984 Cubs playoff game against the Padres. Players wives Kathleen Sanderson, Liz Garvey & Vicki Dernier drop by, as well as Roger Dahl, to check out the proceedings.
Oct 10, 2015
On WCKG in 2007 Bruce Wolf fills in for Spike Manton, and is the first time he & Steve have worked together since WMVP. There is a bit of tension between them at first. Bruce talks about his Princess Diana parody song, and does some coach Dave Wannstedt.
Oct 3, 2015
On this WCKG 2006 grab bag, Steve won't tell Wendy his current favorite burrito place -she'll ruin it. Pete gets a new studio TV. Steve recounts his little league coaching experiences. Plus Janet's going to Spain, & then they catch some tee-ball fever!


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There are dozens of methods used to improve a person's credit score. Which ones pack the most punch? In this post, we'll show you the top three ways to improve your credit score.
When you look at your credit report, you will notice two main forms of credit: installment debts and revolving credit. Installment debts are those where you took out a loan for a specific number of months and agreed to repay the debt in monthly payments. Some examples of these are mortgages, car loans, and personal loans. Having a few of these that you pay on or ahead of schedule will strengthen your credit the most. They are the best indicators to other creditors as to how you are at keeping up your end of an agreement.
The other form of credit you will see farther down the report is your revolving credit section. These are primarily your credit card debts. Because you can pay a card's balance down to zero and recharge other expenses on the same line of credit, it is continually revolving. Other debts with revolving lines include jewelry store and retail store credit. Remember that furniture suit you financed five years ago? It maybe paid off, by you still have an open revolving line of credit. Again, having a few of these in your report in good standing will help you.
A final item of consideration in improving your credit is your outstanding debt amount in relation to your maximum credit limits. If you just bought a new truck and you have a $5,000 card maxed out, then your overall credit score will drop. Keeping your outstanding balances at or below fifty percent of their maximums will improve your score over time.
Get started by filling in our form
Loan Amount
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When applying for a loan, lenders will look at your credit score to determine whether or not you can afford the repayments. Find out yours for free today.


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Few design trends are as useful as they are beautiful, but seats are increasingly blurring the lines between form and function, with our living spaces reaping the beautiful rewards.
With their purposeful role in our homes, they are in the prime position to make a design statement. So whether you're in store for a comfy couch or some bentwood beauties, we've got the low-down on the sweetest seats around. Although a lifelong member of the practicality party, dining chairs are getting a cool 2019 makeover. We're increasingly seeing more creativity injected into their design, like the beautiful Venus Chairs by Pillow Talk, pictured. When it comes to couches, it seems bigger is better, with plump silhouettes and over-sized chaise sectionals all the rage right now, which is a plus when it comes to comfort.
Curvy, rounded edges are having a serious moment in 2018. Traditional '70s colours such as mustard, sage and deep jewel tones lend a healthy dose of vintage flair, or keep your finger on the contemporary pulse with of-the-moment shades like cobalt blue or millennial pink. Luxe materials such as velvet are making their luxurious mark. If it's the mid-century aesthetic you're after, fear not – this art deco-inspired trend isn't going anywhere soon. This look is all about opulence and glamour, so look for tuxedo or cabriole-style sofas.
Its modern incarnation incorporates many of the same design motifs as when it first hit the style scene in the 20s. Expect glossy blacks, shiny chrome, deep, tonal hues of purples and reds, bold geometric shapes, funky animal skins and ornate detailing.


text:
cupgtr.f(3) LAPACK cupgtr.f(3) NAME cupgtr.f - SYNOPSIS Functions/Subroutines subroutine cupgtr (UPLO, N, AP, TAU, Q, LDQ, WORK, INFO) CUPGTR Function/Subroutine Documentation subroutine cupgtr (characterUPLO, integerN, complex, dimension( * )AP, complex, dimension( * )TAU, complex, dimension( ldq, * )Q, integerLDQ, complex, dimension( * )WORK, integerINFO) CUPGTR Purpose: CUPGTR generates a complex unitary matrix Q which is defined as the product of n-1 elementary reflectors H(i) of order n, as returned by CHPTRD using packed storage: if UPLO = 'U', Q = H(n-1) . . . H(2) H(1), if UPLO = 'L', Q = H(1) H(2) . . . H(n-1). Parameters: UPLO UPLO is CHARACTER*1 = 'U': Upper triangular packed storage used in previous call to CHPTRD; = 'L': Lower triangular packed storage used in previous call to CHPTRD. N N is INTEGER The order of the matrix Q. N >= 0. AP AP is COMPLEX array, dimension (N*(N+1)/2) The vectors which define the elementary reflectors, as returned by CHPTRD. TAU TAU is COMPLEX array, dimension (N-1) TAU(i) must contain the scalar factor of the elementary reflector H(i), as returned by CHPTRD. Q Q is COMPLEX array, dimension (LDQ,N) The N-by-N unitary matrix Q. LDQ LDQ is INTEGER The leading dimension of the array Q. LDQ >= max(1,N). WORK WORK is COMPLEX array, dimension (N-1) INFO INFO is INTEGER = 0: successful exit < 0: if INFO = -i, the i-th argument had an illegal value Author: Univ. of Tennessee Univ. of California Berkeley Univ. of Colorado Denver NAG Ltd. Date: November 2011 Definition at line 115 of file cupgtr.f. Author Generated automatically by Doxygen for LAPACK from the source code. Version 3.4.2 Tue Sep 25 2012 cupgtr.f(3)[top]
Vote for polarhome


text:
Thanks from First English
Dear Members of Holy Trinity,
You have continued to support our ministry in many, many ways. The dishwasher is in the basement pending installation; your women provided a lovely lunch and craft time for our neighborhood women and your financial support goes toward summer activities for our kids! Thank you!


text:
Editor's Perspective:
What We Already Know about This Topic:
Positive γ-aminobutyric acid type A (GABAA) receptor modulators bind with higher affinity when the receptor is in the open state, increasing the fraction of open state receptors and, thereby, enhancing receptor function
Appending a phenyl ring substituent group onto the phenyl ring of etomidate abolished its conformational state selectivity and binding site selectivity, reducing the intrinsic efficacy of etomidate and turning it into an anesthetic-selective competitive GABAA receptor antagonist
What This Article Tells Us That Is New:
γ-Aminobutyric acid type A (GABAA) receptor positive modulatory activities of phenyl ring–substituted etomidate analogs decreased with increasing substituent group volume, reflecting decreases in both potencies and efficacies of the analogs
Their GABAA receptor positive modulatory activities were strongly correlated with their affinities for the two β+ – α– transmembrane anesthetic binding sites of the GABAA receptor
Open-state binding affinity decreased progressively with increasing substituent group volume
Naphthalene-etomidate, an etomidate analog containing a bulky phenyl ring substituent group, possesses very low γ-aminobutyric acid type A (GABAA) receptor efficacy and acts as an anesthetic-selective competitive antagonist. Using etomidate analogs containing phenyl ring substituents groups that range in volume, we tested the hypothesis that this unusual pharmacology is caused by steric hindrance that reduces binding to the receptor's open state.
The positive modulatory potencies and efficacies of etomidate and phenyl ring–substituted etomidate analogs were electrophysiology defined in oocyte-expressed α1β3γ2L GABAA receptors. Their binding affinities to the GABAA receptor's two classes of transmembrane anesthetic binding sites were assessed from their abilities to inhibit receptor labeling by the site-selective photolabels 3[H]azi-etomidate and tritiated R-5-allyl-1-methyl-5-(m-trifluoromethyl-diazirynylphenyl) barbituric acid.
The positive modulatory activities of etomidate and phenyl ring–substituted etomidate analogs progressively decreased with substituent group volume, reflecting significant decreases in both potency (P = 0.005) and efficacy (P < 0.0001). Affinity for the GABAA receptor's two β+ − α– anesthetic binding sites similarly decreased with substituent group volume (P = 0.003), whereas affinity for the receptor's α+ – β–/γ+ – β– sites did not (P = 0.804). Introduction of the N265M mutation, which is located at the β+ − α– binding sites and renders GABAA receptors etomidate-insensitive, completely abolished positive modulation by naphthalene-etomidate.
Steric hindrance selectively reduces phenyl ring–substituted etomidate analog binding affinity to the two β+ − α– anesthetic binding sites on the GABAA receptor's open state, suggesting that the binding pocket where etomidate's phenyl ring lies becomes smaller as the receptor isomerizes from closed to open.
Megan McGrath, Zhiyi Yu, Selwyn S. Jayakar, Celena Ma, Mansi Tolia, Xiaojuan Zhou, Keith W. Miller, Jonathan B. Cohen, Douglas E. Raines; Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology 2018;129(5):959-969. doi: https://doi.org/10.1097/ALN.0000000000002356.
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© 2020 American Society of Anesthesiologists
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