text:
TORRANCE (AP) — Toyota is recalling 615,000 Sienna minivans in the U.S. because they can inadvertently shift out of park and roll away.
The recall involves Siennas from the 2004, 2005, 2007, 2008 and 2009 models years.
Toyota said Thursday that the shift locking device can potentially be damaged. If that happens, the minivans can shift out of park even if the driver isn't depressing the brake pedal.
Toyota said it has gotten reports of 21 accidents and 2 injuries related to the problem.
Owners will be notified of the recall by mail. Dealers will replace the shift-lock device for free.
(© Copyright 2013 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.)

subset: commoncrawl


text:
Take full control of equipment performance and food product quality in your filling and packaging operation with PLMS Centre, our packaging line monitoring system. The production of foods and beverages is a value chain that requires constant monitoring to ensure food safety, consistent quality, high throughput and minimized operating cost. In your filling and packaging line, you need to be able to manage all the data, in detail, in order to assure top performance shift after shift, year after year. PLMS Centre automatically collects and presents consolidated operational data in a user-friendly interface.
PLMS Centre enables you to monitor process parameters and critical control points in your filling machines and packaging lines. And this in turn gives you the possibility to execute advanced trouble-shooting on machine process variables. Manage your packaging line data with PLMS Centre and benefit from:
Contact us about PLMS Centre
About Tetra Pak
Together with our customers we make food safe and available, everywhere. Since the start in 1951 we have taken pride in providing the best possible processing and packaging solutions for food.
Tetra Pak is one of three companies in the Tetra Laval Group – a private group that started in Sweden. The other two companies are DeLaval and Sidel. Tetra Laval is headquartered in Switzerland.


text:
Women's Intercollegiate Rowing Center Officially Opens
By ODU Athletics
March 31, 2011
NORFOLK - Old Dominion University unveiled its Women's Intercollegiate Rowing Center to the public today at a grand opening ceremony in Norfolk's Lakewood Park, home of the new, state-of the-art facility.
The center, located in Norfolk's Lakewood Park on the Lafayette River, is a two-story, 13,000 square-foot facility that is home to ODU's newest women's athletic team, a sport added to the athletic curriculum in 2008.
The $2.3 million rowing center represents a joint partnership project between the city of Norfolk and the University. Designed by Clark-Nexsen Architecture and Engineering, and constructed by Mid Eastern Builders Inc., the project will also include a 167-foot launching pier, to be completed by midsummer.
"This facility is a prime illustration of how the city of Norfolk and ODU are continuing to enrich the quality of life for our students," said ODU President John R. Broderick. "The boathouse will definitely provide engaging opportunities and first-rate accommodations for the rowing team and its supporters."
The 13,000-square-foot, two-story facility features two heated and air-conditioned bays on the first floor, which provide storage space for eight eight-person shells, six fours, and 12 pair/doubles and singles. Also on the first floor is a locker room that can accommodate up to 60 student-athletes. Located on the second floor are a training area with 40 rowing machines and other workout equipment, coaches' offices and a study area and team lounge with Internet access.
"This is an outstanding facility that will allow our team to practice and train year-round, and grow into what we expect will be a highly competitive program in our athletic department," said C. Wood Selig, athletic director. "There are few rowing programs in the country that have this kind of facility."
Under the direction of interim head coach Dan Garbutt, the rowing team currently has 32 members, and will host its first regatta from the new facility at 8 a.m. Saturday against the University of Miami. Spectators can view the races from the Granby Street and Willow Wood bridges, or along Mayflower Avenue in the Colonial Place section of Norfolk. The squad will compete April 8-9 in the Knecht Cup in Cherry Hill, N.J.; April 15-16 against Bucknell and Colgate in Lewisburg, Pa.; April 23 at the Colonial Athletic Association championship in Fairfax, Va.; and May 12-14 at the Dad Vail Regatta in Philadelphia.
"Lakewood Park is the ideal launch point for our type of crafts," said Garbutt. "The ability to have this access point, on municipal land, to store and launch university boats illustrates the close relationship that exists between the two parties. Without complete cooperation from both the city and the university, a project of this scope would not have been possible. It shows the unique link that rowing and other water sports have with their communities."


text:
Square Black Multi Aperture Frame to fit 4 Photo's
- Buy 6 for £26.99 each and save 13%
- Solid Wood Multiple Aperture Frame - To fit 4 Photo's sized 6" x 4" or 7" x 5" - Real glass (not perspex) - Vintage Distressed Black Frame - Made by ourselves, here in the UK
- Buy 6 for £26.99 each and save 13%
Description Shipping and Returns Customer Reviews Frequently Bought Together
The latest addition to our range of high quality wooden photo frames are these multiple aperture frames in our hugely popular 'Cotswold Collection' range of mouldings. Available in 4 colours, A light pastel green, an off white, a french grey and a black. This range of frames has already proven to be very popular the last year or two. A beautiful solid wood frame that comes with glass (not perspex). Available to fit photo's sized 6" x 4" and 7" x 5",
- This item is usually delivered within 2-3 working days.
- You will get an email on the day we despatch so you know your frames are on their way.
- For deliveries made by Interlink Express, they will contact you on the morning of delivery detailing a 1 hour delivery window.
- Delivery costs £4.95 for most of England and Wales and most of Scotland (except Scottish Highlands).


text:
Can My Dog Give Me a Blood Infection?
You share more than you realize with your dog, including bacteria. Exposure to germs in your dog's mouth can increase your risk of developing capnocytophaga, a serious blood infection.View Article
You are using an outdated browser. Please upgrade your browser to improve your experience.
Surf Doggies: Teaching Your Dog to Surf is Easier Than You May Think
Want to enjoy your favorite beach activity with your pet? Try these tips.
There's nothing better than cooling off in a pool, lake or the ocean on a hot day, particularly if you wear a fur coat year-round. Unfortunately, our pets aren't aware of the dangers that water can pose. A few precautions can help you ensure that your pet enjoys the water safely this summer.
Can Your Pet Swim?
All dogs are not natural swimmers. Some dogs, and most cats, don't even like the water. If you encourage your dog to enter the water without verifying swimming skills, you may need to perform an emergency rescue. Test your dog's skills by following these steps:
Follow These Tips to Keep Your Pet Safe
If you live or play near the water, pet water safety is particularly important. Follow these tips to prevent accidents and injuries.
Water Safety Magazine: Pet Safety Tips, 6/4/12
WebMD: Dogs and Water Safety
San Antonio Humane Society: Water Safety
Skamper-Ramp: Home Page
DogsLife: Teach Your Dog to Surf, 6/27/14
Surf Dog USA: Teaching Your Dog to Surf


text:
Cracking the Code—The Human Genome Project in Perspective [Part II]
|Bert Thompson, Ph.D.
[EDITOR'S NOTE: Part I of this two-part series appeared in the August issue. Part II follows below and continues, without introductory comments, where the first article ended. However, the reader may find it useful to have on hand the "Genetic Glossary," since some terms in that glossary are employed here for the first time.]
Chance is incapable of creating a single molecule, let alone an entire universe. Why not? Chance is no thing. It is not an entity. It has no being, no power, no force. It can effect nothing for it has no causal power within it (1984, p. 118).Chance cannot create. And it certainly cannot create something as complex as the genetic code. Furthermore, as science writer Matt Ridley observed: "DNA is information, a message written in a code of chemicals" (1999, p. 13). And, as information scientist Werner Gitt correctly noted: "Coding systems are not created arbitrarily, but they are optimized according to criteria.... Devising a code is a creative mental process. Matter can be a carrier of codes, but it cannot generate codes" (1997, pp. 59,67, emp. added). Whence, then, has come the genetic code? What "creative mental process" imposed the information on it that it contains? In their textbook, The New Biology, evolutionists Robert Augros and George Stanciu wrote:
What cause is responsible for the origin of the genetic code and directs it to produce animal and plant species? It cannot be matter because of itself matter has no inclination to these forms.... There must be a cause apart from matter that is able to shape and direct matter. Is there anything in our experience like this? Yes, there is: our own minds. The statue's form originates in the mind of the artist, who then subsequently shapes matter, in the appropriate way.... For the same reasons there must be a mind that directs and shapes matter in organic forms (1987, p. 191, emp. added).In speaking of the origin of the genetic code, and the simultaneous appearance of the decoding mechanism that accompanies it, evolutionist Caryl Haskins lamented: "By a pre-Darwinian (or a skeptic of evolution after Darwin) this puzzle would surely have been interpreted as the most powerful sort of evidence for special creation" (1971, 59:305, emp. added, parenthetical comment in orig.). The late evolutionist Carl Sagan of Cornell University admitted:
The number of possible ways of putting nucleotides together in a chromosome is enormous. Thus a human being is an extraordinarily improbable object. Most of the 102.4x109 possible sequences of nucleotides would lead to complete biological malfunction (Sagan, 1997, 22:967, emp. added).Sir Francis Crick therefore wrote:
An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going (1981, p. 88, emp. added).Wilder-Smith offered the following observation about the origin of the genetic code.
The almost unimaginable complexity of the information on the genetic code along with the simplicity of its concept (four letters made of simple chemical molecules), together with its extreme compactness, imply an inconceivably high intelligence behind it. Present-day information theory permits no other interpretation of the facts of the genetic code (1976, pp. 258-259, emp. added).This is the very point that Gitt made in his 1997 book on information theory when he wrote: "The coding system used for living beings is optimal from an engineering standpoint. This fact strengthens the argument that it was a case of purposeful design rather than fortuitous chance" (p. 95, emp. added). British evolutionist Richard Dawkins once observed: "The more statistically improbable a thing is, the less we can believe that it just happened by blind chance. Superficially the obvious alternative to chance is an intelligent Designer" (1982, p. 130). I suggest, however, that since the genetic code "appears to be almost a miracle" which "implies an inconceivably high intelligence behind it," then it hardly is "superficial" to believe that it must have had a designer—the Creator-God of the Universe.
A DNA molecule is comprised of thousands of long chains of nucleotides (polynucleotides) each consisting of three parts. One part is the pentose or five carbon sugar known as deoxyribose. A second part is a phosphate group, and the third part is a nitrogen base of either adenine (A), guanine (G), cytosine (C) or thymine (T). Alternating sugar and phosphate molecules connect each nucleotide chain in a ladder type configuration coiled around a central axis in a twisted double spiral or helix. The two chains run in opposite directions with 10 nucleotides per turn of the helix. The rungs of the bases are pairs of either adenine and thymine (A-T) or cytosine with guanine (C-G). A relatively weak hydrogen bond connects these bases... (1997, p. 34).Genes, then, are specific segments of DNA (although not all DNA assumes the form of genes; some resides in extranuclear organelles such as plasmids, and some is non-coding). Chromosomes—which consist of DNA and other material—are macromolecules composed of repeating nucleotides that serve as carriers for genes, with thousands of genes being aligned along each chromosome. [Not all human genes, however, are found on chromosomes; a few reside within mitochondria located in the cytoplasm; see Ridley, 1999, p. 9.] Each chromosome consists of a pair of long (roughly three feet), tightly coiled, double-stranded DNA molecules, with each chromosome possessing one long arm and one short arm separated by a middle "pinch point" known as a centromere.
Every living thing has a specified number of chromosomes in each somatic cell. A corn cell has 20; a mouse, 40; a gibbon, 44; and a human, 46. Germ cells in humans, however, have only 23 chromosomes each so that during the union of the male and female gametes, the total will be the standard human number of 46 (23 + 23). [Of these, 22 pairs are numbered in approximate order of size from the largest (#1) to the smallest (#22), while the remaining pair consists of the sex chromosomes: two large X chromosomes in women, one X and one small Y in men.] As a result, genes end up being inherited in pairs consisting of one portion from the father and one from the mother, thereby ensuring genetic diversity.
|Figure 1 — The structure of a nucleotide. Circles represent carbon atoms. In DNA the sugar is deoxyribose, with a hydrogen atom at position X; in RNA the sugar is ribose, with a hydroxyl (OH) group at position X. In DNA, the base can be A,G,C, or T; in RNA, the base can be A,G,C, or U.
Thanks to the progress that has been made in both genetics and molecular biology, we now possess techniques by which it is possible to determine the exact chemical sequence of any gene from any organism. The genotype is the complete set of genes that the organism possesses—something determined at the time of conception for multicellular organisms. It is the same in all cells of an individual organism. The genotype of all cells derived from a particular cell will be the same, unless a mutation occurs. [It is estimated that 90% of all known gene mutations occur in autosomal chromosomes (as opposed to sex chromosomes—see Macer, 1990, p. 4).] For organisms that reproduce sexually, the genotype of each new individual will be different since the genes from the two parents are combined. The phenotype of an individual is determined by the constant interaction of their genotype and the environment.
The DNA molecule truly is amazing, but it still has certain built-in limits. As geneticist Richard Lewontin remarked: "DNA is a dead molecule, among the most nonreactive, chemically inert molecules in the living world" (2000, p. 141). Matt Ridley referred to DNA as "a helpless, passive piece of mathematics, which catalyses no chemical reactions" (1999, p. 17). What is the point of such statements? Jonathan Wells has explained:
Although molecular biology has demonstrated conclusively that DNA carries the genetic code for the amino acid sequences of proteins, this is not sufficient to specify a whole organism. Combining DNA with all the ingredients necessary for protein synthesis does not make a cell.... Molecular biology has shown that an organism's DNA specifies the building materials. It turns out, however, that the assembly instructions are largely in other components of the cell, and that the floor plan has not yet been discovered. So there are clearly other factors involved in heredity and development besides DNA (1998, pp. 62,64).[This information will become important in separating fact from fiction in the discussion below on the Human Genome Project.]
Strictly speaking, of course, DNA is not actually a self-replicating molecule. As Lewontin explained:
DNA has no power to reproduce itself. Rather it is produced out of elementary materials by a complex cellular machinery of proteins.... The newly manufactured DNA is certainly a copy of the old, and the dual structure of the DNA molecule provides a complementary template on which the copying process works...[but] no living molecule is self-reproducing (2000, p. 142, emp. in orig.).DNA does replicate, however. And the process by which it does so is an enormously complex one with many different components that interact to ensure the faithful transfer of genetic information to the next generation. Biochemist Michael Behe noted:
A large number of parts have to work together to that end. In the absence of one or more of a number of the components, DNA replication is either halted completely or significantly compromised, and the cell either dies or becomes quite sick (1998, p. 185).What, then, is involved in reproducing the DNA molecule so that it can be passed from cell to cell and generation to generation?
|Figure 2 — DNA shown in double-helix, parent-strand form (top), and during replication of two new complementary strands (bottom). Source: DOE Human Genome Program [on-line], http://www.ornl.gov/hgmis/
The genome is a very clever book, because in the right conditions it can both photocopy itself and read itself. The photocopying is known as replication, and the reading as translation. Replication works because of an ingenious property of the four bases: A likes to pair with T, and G with C. So a single strand of DNA can copy itself by assembling a complementary strand with Ts opposite all the As, As opposite all the Ts, Cs opposite all the Gs and Gs opposite all the Cs. In fact, the usual state of DNA is the famous double helix of the original strand and its complementary pair intertwined.
To make a copy of the complementary strand therefore brings back the original text. So the sequence ACGT becomes TGCA in the copy, which transcribes back to ACGT in the copy of the copy. This enables DNA to replicate indefinitely, yet still contain the same information.
Translation is a little more complicated. First the text of a gene is transcribed into a copy by the same base-pairing process, but this time the copy is made not of DNA but of RNA, a very slightly different chemical.... This RNA copy, called the messenger RNA, is then edited....
The messenger is then befriended by a microscopic machine called a ribosome, itself made partly of RNA. The ribosome moves along the messenger, translating each three-letter codon in turn into one letter of a different alphabet, an alphabet of twenty different amino acids, each brought by a different version of a molecule called transfer RNA. Each amino acid is attached to the last to form a chain in the same order as the codons. When the whole message has been translated, the chain of amino acids folds itself up into a distinctive shape that depends on its sequence. It is now known as a protein.
Almost everything in the body, from hair to hormones, is either made of proteins or made by them. Every protein is a translated gene (1999, pp. 6,7,8, emp. in orig.).Yes, the process described above is utterly amazing. But no less amazing is the fact that it takes place in a DNA fiber that is only two millionths of a millimeter thick (barely visible under an electron microscope). Yet the amount of information contained within it "is so immense in the case of human DNA that it would stretch from the North Pole to the equator if it was typed on paper, using standard letter sizes" (Gitt, 1997, p. 90). As Anderson observed: "If the tightly coiled DNA strands inside a single human adult were unwound and stretched out straight, they would cover the distance to the moon half a million times. Yet when coiled, all the strands could fit inside a teaspoon" (1980, p. 50).
The DNA molecule must be incredibly stable, since the genetic information stored within it may need to function in a living organism for up to a century or more. It also must be completely reproducible so that its complex informational content can be passed successfully from generation to generation. As it turns out, DNA does, in fact, possess each of these traits, and thereby fulfills the necessary and essential criteria of stability and replicability. Are we to be convinced, however, that all of this occurred merely by chance?
An organism's genome is its total genetic content. [The phrase "nuclear genome" refers solely to the DNA within the nucleus; the phrase "human genome" refers to all of the DNA contained in an entire human (haploid) cell, rather than just that in the nucleus.] In the late 1980s, scientists began discussing the possibility of obtaining a detailed map and complete DNA sequence of the genome of a variety of organisms, including the bacterium Escherichia coli, the yeast Saccharomyces cerevisiae, the roundworm Caenorhabditis elegans, the fruit fly Drosophila melanogaster (all of which, by the way, had been completed by the end of 1999), wheat, rice, the mouse, and of course, Homo sapiens. [For an update on the progress regarding the sequencing of the genome of the mouse and other species, see Karow, 2000, 283[1]:53.]
The mere thought of mapping all the chromosomes and sequencing all the genes of even a "simple" living organism should be enough to send chills down the spine of every hard-working molecular biologist. After all, a bacterium can have 4 million nucleotide bases in its genetic repertoire, while more complicated organisms such as human beings can possess more than 3 billion. And, curiously, some amphibians and flowering plants have more than 10 times the number of nucleotide bases found in human beings (see Roth, 1998, p. 70; Avers, 1989, pp. 142-143; Fraser, et al., 1995, 270:397-403; Goffeau, 1995, 270:445-446). But, by the beginning of the year 2000, the genome sequences of more than 20 species had been published on the Internet, and the one-billionth base of human DNA had been sequenced (see Macer, 2000). Erika Check, writing in the August 14, 2000 issue of Newsweek, quoted Claire Fraser, head of the Institute for Genomic Research, who suggested that within the next year or so scientists will begin decoding the genomes of the top twenty human pathogens [disease-causing organisms] (136[7]:9). [In fact, in its July 13, 2000 issue, Nature reported that scientists in the country of Brazil had just completed the "first sequence of a free-living plant pathogen" and that their paper (published in that week's issue of the journal) represented "a significant scientific milestone" (see Editorial, 2000a, 406:109; see also Simpson, A.J.G., et al., 2000, 406:151-156). Less than three weeks later, Nature announced in its August 3, 2000 issue that the genes of Vibrio cholerae, the microorganism that causes cholera, had been completely sequenced (see: Heidelberg, et al., 2000, 406:477-483; Check, 2000, 136[7]:9).]
In 1990, the Human Genome Project [or HGP; also sometimes referred to as the Human Genome Initiative] began (see Collins, 1997, p. 98). The name is a collective moniker for several projects that actually began in the late 1980s in several countries, following a decision by the United States Department of Energy [DOE] to: (a) create an ordered set of DNA segments from known chromosomal locations; (b) develop new computational methods for analyzing genetic map and DNA sequence data; and (3) develop new instruments and techniques for detecting and analyzing DNA (see Office of Technology Assessment, 1988). However, some in the biological community were a bit wary of DOE physicists "doing biology." Thus, because the National Institutes of Health [NIH] is the major funder of biomedical research in America, its scientists signed on to join the project. [Francis Collins, M.D., Ph.D., is the head of the U.S. Human Genome Project.]
Shortly after the formation of the HGP in the United States, scientists from several foreign countries were invited to join in the effort, which resulted in the formation of the HGP international analogue—the Human Genome Organization [HUGO]. Included in the international effort were scientists from France, Great Britain, Japan, and elsewhere. In 1991 the Human Genome Diversity Project [HGDP] was begun, with a mandate to collect DNA samples for analysis from at least 25 unrelated individuals in 400 different populations around the world. Dr. Luigi Cavalli-Sforza, professor emeritus of genetics at Stanford University, heads the program (see Macer, 2000; Cavalli-Sforza, 2000, p. 69). In mid-1999, British science writer Matt Ridley wrote in his book, Genome:
Being able to read the genome will tell us more about...our nature and our minds than all the efforts of science to date. It will revolutionise anthropology, psychology, medicine, palaeontology and virtually every other science.... Some time in the year 2000, we shall probably have a rough first draft of the complete human genome. In just a few short years we will have moved from knowing almost nothing about our genes to knowing everything. I genuinely believe that we are living through the greatest intellectual moment in history. Bar none (p. 5, emp. added).Ridley's prediction has come true. The HGP now has achieved one of its main goals—producing a "rough first draft" of the human genome. Two groups—one governmental [the HGP] and one from corporate America [Celera Genomics, headed by its CEO, Dr. Craig Venter]—had been pursuing the goal of mapping the entire human genome independently of each other. [On January 10, 2000, for example, scientists at Celera announced they had sequences equal to over 90% of the human genome, and 97% of all genes, in their database (see Editorial, 2000b).] Eventually, however, the two groups agreed to work together. And work they did! On June 26, 2000, the announcement was made that, for all practical purposes, the mapping of the human genome was complete. In its cover story the following week (July 3), Time magazine reported on the meaning and importance of the announcement.
After more than a decade of dreaming, planning and heroic number crunching, both groups have deciphered essentially all the 3.1 billion biochemical "letters" of human DNA, the coded instructions for building and operating a fully functional human....
Armed with the genetic code, scientists can now start teasing out the secrets of human health and disease at the molecular level—secrets that will lead at the very least to a revolution in diagnosing and treating everything from Alzheimer's to heart disease to cancer, and more (Golden and Lemonick, 2000, 156[1]:19-20).The Human Genome Project is set up to proceed in two distinct stages, the first of which is that of "physical mapping." This phase will examine short stretches of DNA in order to determine sequences along each chromosome as "landmarks" (somewhat like the mile markers found along U.S. interstate highways). These markers then will be of importance in finding exactly where, along each chromosome, particular genes reside. In the second phase of the project, various laboratories will examine an entire chromosome (or section of a chromosome, depending on its size) in order to determine the complete ordered sequence of nucleotides in its DNA. It is after this critical second phase, to use the words of Harvard's Lewontin, "that the fun begins, for biological sense will have to be made, if possible, of the mind-numbing sequence of three billion A's, T's, C's, and G's" (2000, p. 162).
Truth be told, the processing of making "biological sense" out of the human genome already has begun in earnest. The December 2, 1999 issue of Nature announced, for example, that the first human chromosome (#22) had been completely sequenced (see Little, 2000, 402:467-468; Dunham, et al., 2000, 402:489-495; Donn, 1999). And in May 2000, the HGP announced that it not only had completed its own working draft of chromosome 22, but also had completed the sequencing of chromosome 21, which is involved with Down's syndrome and several other diseases (see Brown, 2000, 283[1]:50-55; for a full account of the chromosome 21 story, see Scientific American's Web site at http://www.sciam. com/explorations/2000051500chrom21).
But where, exactly, is the HGP now? Almost all of the genome data already are being used. As of June 2000, 85% of the human genome was available on the World Wide Web (see Regalado, 2000, 103[4]:97-98). The notion that science somehow will be transformed when we cross a mythical "finish line," however, is wrong. The fact is, science already has been transformed. When Time's writers chose the title "The Race Is Over!" for their cover story, they were correct—in the sense that everyone now can partake of the knowledge regarding the 3 billion DNA base pairs. That is the great achievement at this point in time. But there is more to it than that because there is much we still do not know, and much work yet to be done. Why is this the case? Wade Roush, writing in the May/June 2000 issue of Technology Review (shortly before the completion of the human genome project was announced), suggested:
...[W]e have only the foggiest picture of how our 100,000 genes interact to regulate one another's expression and to direct protein production. Extrapolating from the genome to the whole organism is therefore akin to writing a history of New York City based on the phone directory. Another problem is that DNA, by itself, doesn't produce or explain anything (2000, 103[3]:113).In an interview in the July/August, 2000 issue of Technology Review, Eric Lander, who is the director of the Whitehead Institute for Biomedical Research/MIT Center for Genome Research (the world's most productive academic gene sequencing facility and the flagship of the international Human Genome Project), admitted:
The truth is that the human genome is going to have all kinds of nasty little bits that are hard to fill in at the end: the middles of chromosomes, called the centromeres, the ends of chromosomes, called the telomeres, and so on. This is not like the transcontinental railroad, where at some point someone is going to nail the golden spike, and then and only then can you go cross-country. There is no golden nucleotide to be nailed into the double helix at the end....
The genome is a very elaborate program, and we don't know how to read it. It's as if we have some ancient computer code that was written...years ago and now we are trying to figure out what it does. I think what biologists are going to be doing for the next decade is figuring out the circuitry of the genome by monitoring how the 50,000 to 100,000 genes are turned on and off and how all the proteins come on and off in the cell (see Regalado, 2000, 103[4]:97-98).The following report from Time accurately expressed Dr. Lander's point.
HGP scientists may have decoded 97% of the genome's letters—the remaining 3% are generally considered unsequenceable and irrelevant—but they know the order of only 53% of them. It's as if they've got the pages in the so-called book of life in the proper order but with the letters on each page scrambled....
Celera, by contrast, has not only the pages but all the words and letters as well—though neither side can yet say what most of these words and letters mean.... [Craig] Venter points out that identifying the order of the letters in our genetic alphabet is just a first step. Still ahead for Celera as well as its competitors: the much more complicated task of telling what those letters mean, what they do and what can be done if the messages they spell out are in error—a prime cause of human disease and suffering (Golden and Lemonick, 2000, 156[1]:20-21).
"ERROR MESSAGES"—THOSE PESKY SNPs
Scientists...are putting together databases of tissue samples to look for one-letter genetic differences.... Both the Human Genome Project and Celera are currently sequencing the genomes of many different people, of both sexes and all sorts of ethnic backgrounds, to get a better sense of where the SNPs are (2000, 156[1]:28).Luigi Cavalli-Sforza, director of the Human Genome Diversity Project that is examining DNA samples from over 400 populations worldwide, has explained why accurate knowledge of SNPs is critical.
If we take the DNA from one sperm (or egg) and compare it to the DNA of another random one, we find that there is on average one different nucleotide pair every thousand nucleotide pairs. There are therefore at least three million differences between the DNA in one sperm or egg and the DNA in another. All these differences originated by mutation, a spontaneous error made while copying DNA, which most frequently involves the replacement of one nucleotide by another of the four.... New mutations are therefore transmitted from parents to children.... A change in DNA may cause a change in a protein... (2000, pp. 68,17, emp. added).And a change in a protein within a living system can herald severe problems. Organisms contain thousands of proteins that most often are composed of 300 or more amino acids linked together in chain-like fashion. Substitution of even a single amino acid at a critical position can be lethal (see Roth, 1998, p. 69; Radman, 1988, 259[2]:40-46). In an article in Nature titled "The Book of Genes," Peter Little explained why SNPs are so important within the context of the Human Genome Project.
There is a general consensus that SNPs are probably the cause of most common genetic disorders. We all carry many SNPs but if we are unlucky enough to carry the "wrong" set of changes, we are predisposed to one or other of the common disorders with a genetic component such as diabetes, heart disease, asthma, or cancers.... If knowledge of gene differences can be combined with an understanding of the richness of environmental influences, we will have the key to unlocking the cause of most of the common disorders that kill or otherwise cause suffering (1999, 402:467-468).After reading, digesting, and pondering all of this information about the Human Genome Project, perhaps it will be easier to understand in a clearer fashion why writers like Newsweek's Thomas Hayden have concluded:
Meanwhile, the benefits of genomic research—from predicting risk for hereditary disease to developing new drugs designed for an individual's genetic makeup—are still years away... (2000, 136[1]:51).One scientist, Richard K. Wilson of Washington University (a partner in the public consortium of the Human Genome Project), plainly admitted in an interview in the July 2000 issue of Scientific American:
For a long time, there was a big misconception that when the DNA sequencing was done, we'd have total enlightenment about who we are, why we get sick and why we get old. Well, total enlightenment is decades away (as quoted in Brown, 2000, 283[1]:50).Maybe so. Nevertheless, that does not detract in any way from the success the Human Genome Project already has enjoyed.
...[T]he future holds the promise that man will be able to assemble nucleotides in any desired sequence to produce whatever characteristics of human beings are thought desirable, an awesome and disquieting prospect (1997, 22:967, emp. added).Yes, it is indeed an "awesome and disquieting prospect." Henry Greely, a medical bioethicist at Stanford University, commented on where this kind of thinking may lead when he wrote: "The problem is, we sanctify DNA. People seem to want to be eager to view their genome as their essence, instead of just molecules that pass on certain traits. In our secular culture, it's almost taken the place of the soul" (as quoted in Kloehn and Salopek, 1997, p. C-1).
During an interview with Stanford geneticist David Cox for the August 14, 2000 issue of People magazine, reporter Giovanna Breu remarked: "Some worry that mapping the genome allows us to play God by manipulating life." Dr. Cox, however, responded:
The genome gives us a list of what living things are made up of, but not how they go together and work. It provides one more piece of information that we can start using to make order out of our ignorance and help people to make better decisions in life. But...we just have the parts, not the entire instruction manual. I think God isn't so stupid as to let anyone have that (2000, 54[7]:131).While I, personally, might not have phrased my sentiments in exactly those words, it certainly is invigorating to see a scientist of Dr. Cox's stature give credit where credit is due—to God—for the creation of the "book of life" to which we refer somewhat nonchalantly as the "human genome." And it similarly is refreshing to be able to report that he is not the only scientist involved in the project who has acknowledged God as the Author of the intricate genetic code. At the June 26 press conference held jointly by the President of the United States and the Prime Minister of Great Britain, Dr. Francis Collins, who chairs the Human Genome Project from the National Institutes of Health, spoke in similar terms when he said:
Today, we deliver, ahead of schedule again, the most visible and spectacular milestone of all.... We have developed a map of overlapping fragments that includes 97 percent of the human genome, and we have sequenced 85 percent of this.... It's a happy day for the world. It is humbling for me and awe-inspiring to realize that we have caught the first glimpse of our own instruction book, previously known only to God. What a profound responsibility it is to do this work (see Office of Technology Policy, 2000, emp. added). [NOTE: In an interview that appeared in the March issue of Discover magazine three months earlier, Dr. Collins publicly affirmed his personal faith in the God of the Bible, and commented on how grateful he was to be associated with the HGP as it uncovered some of the "mysteries of human biology"—see Glausiusz, 2000, 21[3]:22.]A profound responsibility indeed! To actually be able to "peek inside" the biochemical code—"whose Builder and Maker is God"—is indeed "humbling and awe-inspiring." And—regardless of how deep we probe or how intelligent we think we are—may it ever be so!
Augros, Robert and George Stanciu (1987), The New Biology (Boston, MA: New Science Library).
Avers, C.J. (1989), Process and Pattern in Evolution (Oxford, England: Oxford University Press).
Behe, Michael J. (1998), "Intelligent Design Theory as a Tool for Analyzing Biochemical Systems," Mere Creation, ed. William A. Dembski (Downers Grove, IL: InterVarsity Press).
Breu, Giovanna (2000), "The Code of Life" [Interview with geneticist David Cox, Codirector of the Human Genome Mapping Center at Stanford University], People, 54[7]:129-131, August 14.
Brown, Kathryn (2000), "The Human Genome Business Today," Scientific American, 283[1]:50-55, July.
Cavalli-Sforza, Luigi (2000), Genes, Peoples, and Languages (New York: North Point Press).
Collins, Francis (1997), "The Human Genome Project," Genetic Ethics: Do the Ends Justify the Genes?, ed. John F. Kilner, Rebecca D. Pentz, and Frank E. Young (Grand Rapids, MI: Eerdmans), pp. 95-103.
Check, Erika (2000), "Sound Smart About Sequencing," Newsweek, 136[7]:9, August 14.
Crick, Francis (1981), Life Itself: Its Origin and Nature (New York: Simon and Schuster).
Dawkins, Richard (1982), "The Necessity of Darwinism," New Scientist, 94:130-132, April 15.
Donn, Jeff (1999), "Chromosome Mapped," [On-line], (ABC News), URL http://abcnews. go.com/sections/science/DailyNews/chromosome991201.html, December 1.
Dunham, I.N. Shimizu, B.A. Roe, S. Chissoe, et al. (1999), "The DNA Sequence of Human Chromosome 22," Nature, 402:489-495, December 2.
"Editorial: Genome Sequencing for All," (2000a), Nature, 406:109, July 13.
"Editorial: Private vs. Public Genomics," (2000b), Nature, 403:117, January 13.
Fraser, C.M., J.D. Gocayne, O. White, M.D. Adams, R.A. Clayton, R.D. Fleischmann, C.J. Bult, A.R. Kerlavage, G. Sutton, J.M. Kelley, et. al. (1995), "The Minimal Gene Complement of Mycoplasma genitalium, Science, 270:397-403, October 20.
Gitt, Werner (1997), In the Beginning Was Information (Bielefeld, Germany: Christliche Literatur-Verbreitung).
Glausiuz, Josie (2000), "Genetic Code-Breaker" [Interview with Dr. Francis Collins, Head of the U.S. Human Genome Project], Discover, 21[3]:22, March.
Goffeau, André (1995), "Life with 482 Genes," Science, 270:445-446, October 20.
Golden, Frederic and Michael Lemonick (2000), "The Race Is Over," Time, 156[1]:19-23, July 3.
Haskins, Caryl P. (1971), "Advances and Challenges in Science in 1970," American Scientist, 59:298-307, May/June.
Hayden, Thomas (2000), "A Genome Milestone," Newsweek, 136[1]:51, July 3.
Heidelberg, John F., Jonathan A. Elsen, William C. Nelson, et al. (2000), "DNA Sequence of Both Chromosomes of the Cholera Pathogen Vibrio cholerae," Nature, 406:477-483, August 3.
Karow, Julie (2000), "The 'Other' Genomes," Scientific American, 283[1]:53, July.
Kloehn, Steve and Paul Salopek (1997), "Humanity Still at Heart, Soul of Cloning Issue: Scientists and Theologians Agree We Are Our Own Persons," Chicago Tribune, C-1, March 2.
Lemonick, Michael (2000), "The Genome is Mapped. Now What?," Time, 156[1]:24-29, July 3.
Lewontin, Richard (2000), It Ain't Necessarily So: The Dream of the Human Genome and Other Illusions (New York: New York Review of Books).
Little, Peter (1999), "The Book of Genes," Nature, 402:467-468, December 2.
Macer, Darryl R.J. (1990), Shaping Genes: Ethics, Law and Science of Using New Genetic Technology in Medicine and Agriculture [On-line], (Eubios Ethics Institute), URL http://www. biol.tsukuba.ac.jp/macer/SG.html.
Macer, Darryl R.J. (2000), "Introduction to the Genome Projects," Ethical Challenges as We Approach the End of the Human Genome Project, ed. Darryl R.J. Macer, [On-line], URL http://www.biol.tsukuba.ac.jp/macer/chgp/chgp2.html.
Monod, Jacques (1972), Chance and Necessity (London: Collins).
Nicholl, Desmond S.T. (1994), An Introduction to Genetic Engineering (Cambridge, England: Cambridge University Press).
Office of Technology Assessment—U.S. Congress (1988) Mapping Our Genes—The Genome Projects: How Big, How Fast? (Washington D.C.: United States Government Printing Office).
Office of Technology Policy—The White House (2000) Remarks by the President—The Entire Human Genome Project, [On-line], http://www.whitehouse.gov/WH/EOP/OSTP/html/00628_2.html.
Overman, Dean L. (1997), A Case Against Accident and Self-Organization (Lanham, MD: Rowman and Littlefield).
Perloff, James (1997), Tornado in a Junkyard (Arlington, MA: Refuge Books).
Radman, M. and R. Wagner (1988), "The High Fidelity of DNA Duplication," Scientific American, 259[2]:40-46, February.
Regalado, Antonio (2000), "Riding the DNA Railroad," Technology Review, 103[4]:94-98, July/August.
Ridley, Matt (1999), Genome: Autobiography of a Species in 23 Chapters (New York: HarperCollins).
Roth, Ariel A. (1998), Origins (Hagerstown, MD: Review and Herald Publishing Association).
Roush, Wade (2000), "Pages—Book Reviews" ["Genome, Schmenone," A Review of Richard Lewontin's book, It Ain't Necessarily So], Technology Review, 103[3]:113, May/June.
Sagan, Carl (1997), "Life," Encyclopaedia Britannica (New York: Encyclopaedia Britannica, Inc.), 22:964-981.
Simpson, A.J.G., F.C. Reinach, P. Arruda, et al. (2000), "The Genome Sequence of the Plant Pathogen Xylella fastidiosa," Nature, 406:151-156, July 13.
Sproul, R.C., John Gerstner, and Arthur Lindsley (1984), Classical Apologetics (Grand Rapids, MI: Zondervan).
Wells, Jonathan (1998), "Unseating Naturalism: Recent Insights from Developmental Biology," Mere Creation, ed. William A. Dembski (Downers Grove, IL: InterVarsity Press).
Wilder-Smith, A.E. (1976), A Basis for a New Biology (Einigen: Telos International).


text: Jean-Baptiste Greuze was one of Europe's first celebrity painters. He built a reputation on instructive paintings that covered the edifying themes of the education of children, the virtues of a simple, provincial family life, and the heroism of everyday activities. Epiphany depicts a peasant family participating in the annual celebration of the gateau de roi (a Catholic feast held each year on the 6th of January), where the children search for a bean hidden in the king's cake, the finder of which will become king for the day. Just as the philosophers Denis Diderot and Jean-Jacques Rousseau were asking the country's bourgeoisie to rid themselves of the distractions and trappings of civilisation – to return to nature and a moral, family life – Greuze's Epiphany makes clear the simple (if completely illusory) pleasures of the honest, peasant family, uncorrupted by the temptations of modern, bourgeois life.


text:
"> "> ">
Our laundry partner Aja White Laundry, located in Hawally , Kuwait, offers a wide range of laundry services for you to choose from - washing & folding, ironing, and more. Choose from their services available according to your laundry needs.
Aja White Laundry is not currently one of our 232 partners. So unfortunately, you will not be able to enjoy justclean facilitties with Aja White Laundry yet. If you would like to order from Aja White Laundry online using justclean app and website, please let us know. Our team will contact them for you and try to onboard them.
In the meantime, you can have a look into our 12 partners ready to pick up your laundry in Hawally. All our partners offer you the following benefits:
1- No markup fees: As a user you will not pay any markup fee. We offer you the cheapest prices for Aja White Laundry services
2- Online ordering: You can order your dry cleaning, pressing, washing & folding or any of our extra services directly on justclean
3- Cash on delivery & online payment supported: You can pay to wash your clothes the way you prefer (online payment, justclean credit, cash on delivery, you name it!)
4- Around the clock support: Our support team is here to help you solve any issues regarding your order, your laundry or anything related to the laundry services we offer
One of the most important feature of justclean is that it works according to your convenience. You can choose the timings of pick-up and drop-off that suits you. You can even choose between entering the individual laundry items yourself or easy order and let us take care of it for you.
What ever you need, we are there for you (only when it comes to laundry though).
Aja White Laundry is a laundry service provider in Kuwait. Currently, the directory has 495 in Kuwait out of which, 49 are located in Hawally. Among 495 in Kuwait, we are confident we will cover all your laundry needs - routine or special. If you have any more queries or some special requests, feel free to contact justclean support team via email, chat or phone call.
There is a good number of laundries in Hawally. It is one of the best served laundry pickup & delivery in Hawalli. You should be able to find the right one for your cleaning services.
If you need any help to choose the right laundry, please do not hesitate to contact us. Our support agents are experts when it comes to choosing the right laundry for your clothes - regular or delicates.


text:
Sold Out
Sea Daisy glass bead charm with Murrini
925 Sterling silver universal core
Bead size is approximately 16 x 8 mm
Core size: 4.5 mm
Weight: Approx. 3.2 g
Absolutely magnificent handmade lampwork bead
Please note
All lampwork glass beads are a hand-made product and therefore totally unique. The featured image is for the sole purpose of illustrating the product.
Safety Chain for the braceletMaterial: Oxidized 925 Sterling silver Weight: 0.98 gLength incl. lobster clasp and closed jump ring: 6.5 cm / 2.56 inchesWidth Rolo chain: Approx. 2mm / 0.08 inchesClosed...
Silver 'Flashy Flower Light' Double Lobster clasp for the bracelet Material: Solid 925 Oxidized Sterling silver Size: 2.4 cm / 0.95 inches Weight: 3 g925 Oxidized Sterling silver 'Flashy Flower Light' Double Lobster lock,...
Sold Out
Natural Rainbow Moonstone faceted charm bracelet beadFine jewelry 925 sterling silver core Universal core fits Pandora, Trollbeads, and all European bracelets Bead size: 14 mm x 8 mmCore size: 4.5 mmSemi-precious stone Weight:...
Sold Out
Blue River high-quality glass bead 925 Sterling silver core rivetsBead size: 15 mm x 9 mmCore size: 4.5 mmFits Pandora, Trollbeads, Chamilia and all European style bracelets Handmade lampwork beadWeight:...


text:
TCR coach on All-Decade baseball team
Roberson baseball coach Eric Filipek was recently one of four ex-UNC Asheville players to be named to the Big South Conference's All-Decade teams.
Filipek has coached the Rams for four seasons, and prior to that was at Asheville Christian Academy for three years. ACA's state championship from 2008 remains the last one won by a Western North Carolina baseball team.
More on the Big South teams from UNCA:
CHARLOTTE, N.C. – Four former UNC Asheville baseball players made the Big South Conference's All-Decade teams on Thursday. The league announced its All-Decades Team as part of its 30th-year anniversary.
Former Bulldog great Brian Shehan, a member of the school's Hall of Fame, made the 1980' All-Decade team, while Eric Filipek and Ty Wigginton earned spots on the 1990's team. Alan DeRatt made the 2000-09 squad.
Shehan (1987-90) was the Bulldogs starting first baseman his entire Asheville career. He was a Big South All-Conference selection in 1988 and 1989. Shehan made the All-Decade team as an infielder. He is still the school's career home-run leader in home runs (42) and second in doubles (56) and RBIs (164). Shehan holds the single-season record for home runs (19) and RBIs (59) that happened in 1989.
Filipek (1993-96) was a versatile player who played at first base, catcher and designated hitter. He made the All-Decade team as a DH. The New Jersey native was a two-time All-Conference selection. Filipek led the Bulldogs in hitting in 1994 (.371) and 1995 (.315) and was the school's Male Athlete of the Year in 1994.
Wigginton (1996-98) was the Bulldogs starting shortstop all three of his year at Asheville. He was an All-Conference selection in 1998 and earned National Player of the Week honors that season when he hit eight home runs, drove in 20 runs in six games. The California native holds the single-season record for doubles (26) and runs scored (67) in the 1998 campaign. Wigginton is a member of the UNC Asheville and Big South Hall of Fames. Ty was the first Bulldog to ever make the major leagues as he enjoyed a productive 11-year career (2002-2013) with eight different teams.
DeRatt (2005-08) is one of the greatest pitchers to ever pitch for the Blue & White. He helped lead the Bulldogs to the 2006 Big South Conference Championships with two wins in the tourney. DeRatt was the 2008 Big South Pitcher of the Year. He is the school's career leader in strikeouts (247), games started (55) and innings pitched (365.2).
- Follow the HS Huddle on Facebook: www.facebook.com/hshuddle or Twitter: www.twitter.com/acthshuddle


text:
Here at Jezebel we get all sorts of interesting messages in our inbox, from helpful tips to furious gibberish. Often, the missives that trend towards the gibberish end of the spectrum strike us as poetic — in the chaos of an email's words, we find a sense of peace. As such, we have taken it upon ourselves to let these messages grow into the poetry they are meant to be. And we will do so by presenting them, word-for-word, as Haikus. Herewith, our first installment of Jezebel's Reader Email Haikus.
I read the arti-
cle with Fluke And Rush............... And Im
offended by your
article... All wo-
men deserve respect. And these
words are not respect-
ful. I will not read
your mag. any more. Just be
cause Rush offended
all women. Some words
should have never been create-
d. Women deserve
respect..... even wo-
men shouldnt be using thos
words. [Insert four random syllables here.]
-Sent Wednesday, Mar 14, 2012 at 2:37 PM


text:
Puzzle Boy Flash
Puzzle Boy Flash is a puzzle game of the block-pushing Sokoban variety. Your goal in each level is to get Puzzle Boy to the exit stairs, using only the [arrow keys] to direct him. Push blocks and rotate turnstiles by walking into them. Bridge gaps by plugging them with boxes. If your brain likes to be teased, tickled, maybe slapped around a little, give this one a try.Read More
82 Comments
I'm stuck on an easy level. And while every level so far I've been able to see that there should be a solution, this one just looks impossible. I've tried to 'think it backwards' but keep hitting the same problem - in order to solve this level my guy has to teleport through walls!
It's the sort of car-shaped one with the sliding vertical bricks. And as far as I can tell, there's only one way you can go for a little while... by the time you have a choice of which brick to push, you've blocked off the exit irretrivably!
There's actually a psychological explanation for why that is so:
When problem solving, sometimes we narrow our mindset to exclude essential information that would lead us to a solution.
Therefore, it is helpful to get our minds off the matter for a few moments. This pause can act as a mindset 'reset' and allow use to approach the problem from a different perspective again.
Going through the motions of posting a comment helps to get your mind off the matter for a moment or two. :)
(So does playing a game or two!) :D
Level 8 Walkthrough
--Label blocks in your head from 1 to 8 from right to left, top to bottom.
--Push Block #1 left.
--Go to bottom of screen and push Block #1 UP ONE space.
--Go to top of screen and push Block #1 RIGHT.
--Push Block #3 DOWN TWO spaces.
--Push Block #2 Right and move on down to the bottom.
--See Block #6? It's to the left of the two stacked blocks. Move that baby up one.
--Push Block #4 (which is the top stacked block) to the RIGHT as far as you want.
--Walk your little baby to the bottom left of the screen and push the last block up to exit the maze.
Easy Floor 5 solution:
-Move the yellow block one space upward.
-Rotate the turnstile so that it's horizontal. (Stand at the lower left and push rightward on the end of it.)
-Move the yellow block left to the wall, then down one space, placing it in front of the pit. Rotate the turnstile again and fill the pit.
Level 4, nested spoiler/hint style:
The black areas are NOT pits, just places you can't walk.
The yellow blocks turn into places to walk...
...if they fit fully into a black space.
Could you push the yellow block farther...
...if there was more blue somewhere? Final walkthrough next:
Push the yellow block up or down one, then go all the way to the respective top or bottom edge and push the yellow block to screen left until it drops into the black hole.
I liked it a lot... it really is a fickle puzzler. I'm used to playing Flash games that rely heavily on a single mechanic, but I like that this game has several different mechanics that all play off each other, such as the revolving doors and the sliding blocks. Each works perfectly alone, but together they work harmoniously.
As Psychotronic mentioned, the controls confused me a bit. I had trouble figuring out which button was the "switch to other guy" button, and I ended up doing the whole "hitting every button on the keyboard" maneuver, and eventually figured it out. But beyond that, a solid game. I'm a sucker for Sokoban games :).
Medium level 2 is a big level, but here's a few hints:
Push four blocks into the pit. In order, they are: the 2-high block on the left, the 3-wide block on the left, the singleton behind the spinning T, and the 3 high block on the right. The 5-high block need not move at all.
Push the blocks into the pit with their right edge aligned on the third column from the left. They can overhang without falling as long as they have at least one support.
I hope those hints help. It's a long level, with pushing blocks out of the way and into places where you can walk around them.
I too was stuck on level 3 of medium. I just managed it though, it turns out I was making it much harder than it needed to be.
you simply need a straight bridge from right to left, across the middle of the chasm
So get the single blocks over to the right somehow (in the storage spots top and bottom to be safe), then use those 2 plus the horizontal block to form the bridge.
Having just done medium level 9 again to help out Annonymous, I have realised the serious flaw of this game - it's nigh on impossible to do a walkthrough ;)
Broadly speaking for that level you have to use the central and right mini-mes to clear the right side of the board. Bring in the left mini-me to help out with one of the moves which leads to you being able to push that big block down and open up access to the exit.
Am now well and truly stuck on hard level 1!
Ren, some observations on medium level 6. If you want specific directions, let me know :
The upper four-height block can't move forward or you will never be able to move it from blocking two spaces (because of the central hole). Therefore, the lower four-height block must move forward where it will remain permanently, blocking any potential use of the three-height block. So the only way to bridge the gap is with a combination of the two-height block and the single block. The two height block can only pass on the lower side due to the two-height hole on the upper side. The single block must pass through the middle, but you have to maneuver around it on the top side to position it correctly.
Easy level 9
Push top and bottom yellow squares in one.
Move centre yellow square down one.
Push top yellow square up to top, then push bottom yellow square down to bottom.
Flick top blue thing upwards and bottom blue thing downwards.
You can then get to the exit
Hope this works, haven't done a spoiler on here before!
To elaborate a little more on what Joolz has posted about Medim Level 9
I'm going to describe the bloocks in widthxheight form. The key to moving the 3x2 block is first getting at the 1x2, 3x1, and 2x1 blocks. But lets try a full walkthrough.
First, move the middle guy directly below the 1x1 block by him.
Then use the right guy to push the 1x2 block next to the middle guy down as far as possible. Continuing to use right guy, move the lowest of the 2x1 blocks to the right two spaces. Then move the 1x1 block thats above that all the way to the right, thus getting it out of the way. Leave right guy here for now.
Switch back to middle guy. Push the 1x1 block up two spaces, then move around it and push it all the way down. Then go to the left rotating L block, and move up with it, leaving middle guy snug in the corner of the L up against a 2x1 block.
Switch to right guy. Move the right side 2x1 block down one space.
Switch back to middle guy. Right guy moving that block should have given you room to push the 2x1 block next to middle guy. So push it to the right one space.
Switch to right guy. Move the 2x1 block that he moved last time to the left two spaces.
Switch to middle guy. Push the lower 2x1 (that right guy just moved) down two spaces, right one space, then down one more space. Move middle guy back into the nook of the rotating L block.
Switch to right guy. Have him move the 2x1 block that is below the right rotating L block right, down, left two, down two, then right, so it sits directly above the last block you were moving.
Make sure the left rotating L block is in L position. Switch to left guy. Have him push the 1x1 block up to get out, then push the 1x1 block above that first one to the right three. Go back and push the first 1x1 block down as far as it can do. Make sure you have someone in the crook of the L! Push the 1x1 up two spaces. It should now be to the right of the crook in the L.
Switch to middle guy. Push the 1x1 block all the way to the right, then down one. Now all three guys are together and it doesnt matter who does what.
Have someone go up to the right L block, and push it to the right, so it looks like an r. Then push the left L block down so it also looks like an r. Now move one of your guys next to the 1x2 block at the top. We will call him top guy.
Have top guy push the 1x2 to the left one space.
Have someone else push the uppermost 2x1 (2 squares below top guy) to the right one space. Move all three guys over the the right of the right L block.
Have top guy push the 2x1 down three spaces.
Have someone push the 3x1 down one space, then push the 2x3 down three spaces, push the leftmost 1x1 up one space, then the leftmost 2x1 up one space, and you should be done.
For those of you like me who are beginning to waste serious time on this... I found a full walkthrough (at least for the medium puzzles) at http://faqs.ign.com/articles/539/539220p1.html
For level 10 medium you need to notice two things:
First of all, see how the symmetry is off at the bottom of the screen? Secondly, you will need to move the blocks upwards, not laterally, in order to complete this one. I'm not inclined to write a how-to on this as it was complicated, and if you've made it to level 10 then you should have the basic skills needed to complete it with those two hints.
For level 1 hard:
It is doable, but it took me a long time to figure it out. You'll need to move each piece several times to make room, and at one point you'll block yourself from getting back to the top, but if you align the blocks right you can do it. Don't forget you can move the 3X1 blocks down almost to the door.
I think that level 2 hard was a LOT easier than level one, and level 3 was pretty easy too. I'm on level 4 now, looks complicated but we'll see.
@Darfir -
For Level 3 medium, the first thing you need to do is
Move the two single blocks over to the right side. You'll need to be able to move those two blocks later because
they form half the bridge you need to cross the gap.
The other thing you need to do is
move the top and bottom vertical blocks to the left. That lets you finally get
the middle vertical block out of the way.
medium level 8 :
top 1x1 left 2
right 1x1 down
1x3 left down left
middle right 1x1 left 2 down
1x1 below you down
2x1 left up 2
2x1 right 1
1x1 above you up 1
1x1 above one you just moved up 2 left 2 down left
bridge gap with 2 of the remaining 1x1s
1x2 all the down
1x1 fills gap above it
remaining 1x1s bridge top gap left to right
wow. finished hard. that took some mental power. the last level is tough. basically taking apart the puzzle in a very limited space and then put it together in an extremely limited space to make a "plank" towards the stair. I'll give a few hints on laying the plank for the second half of the puzzle cause just getting to it is a pain...
The planks to go left and up use mostly two kinds of blocks of the 1s, 2s, and 3s (regardless if they are laying down or standing)
The plank to head down to the stair are all the same kind of block
1s & 3s then use the 2s.
There may be more than one way to do it, but this is the gist of how I got there. Whew!
There's a complete walkthrough at:
Leave a comment [top of page]


text: In 1789 Mozart arranged George Frideric Handel's Messiah on behalf of a group of Viennese noblemen.He abridged the work in an effort to tauten the drama, transposed arias to suit his singers' abilities and he subjected it to a fundamental re-orchestration to adapt the sound of the work to the musical taste of his time. lt was not until the 20th century that the historical and musical value of Mozart's Messiah arrangement was reappraised. Mozart's interpretation of Handel's Counterpoint and his synthesis of Baroque and Classical stylistic elements give the work a compelling new sound.


text:
I've been meaning to post this recording for a while. Nwanyi Ma Obi Diya (Onyeoma C.Y. Records CYLP 016, 1984) by the Obi Wuru Otu Dance Group of Ihiagwa-Owerri is guaranteed to fill the dance-floor at any Igbo party it's played.
The vocal stylings of Rose Nzuruike (above) were what made Nwanyi Ma Obi Diya stand out amid a torrent of similar releases during the '80s, and what sends Igbos, and especially Owerri indigenes, into a swoon. Which is not to short-change the talents of the group itself (below) and especially its leader, Madam Maria Anokwuru. Released on an obscure Onitsha record label, it became one of the biggest-selling Igbo records of all time.
The title tune, opening up the medley on Side One of the album, means "A Woman That Knows her Husband's Heart." The ladies sing that good behavior is better than beauty and that a woman who knows her husband's heart will work with him when times are tough. "Ego Kirikiri" literally means rattling money and refers to the olden days when commerce was conducted with cowrie shells. The group sings "Igbo je akpo ya ojo mma - Igbos called it good money" and "Owerri nnu ahuna onwu ozigbo mmadu bara uba - Owerri, you see that not everyone was rich." Furthermore, "Onye ogazirila nya nwe mmeri - If you are rich you win." Side One concludes with a paean to Chukwuemeka Odumegwu Ojukwu, the leader of the separatist state of Biafra, who was pardoned by Nigeria's president at the time, Shehu Shagari, and allowed to return to Nigeria in 1980. The group welcomes Ojukwu back to the land of his birth and sing that they are overjoyed at his return:
Obi Wuru Otu Dance Group of Ihiagwa-Owerri - Nwanyi Ma Obi Diya/Ego Kirikiri (Cowries)/Onye Ije Nno-Ezennadi
On Side Two, the group sing that they are called Obi Wuru Otu - "One Heart for All." They entreat everyone to be careful, because God's way is where humans prove their value. "Ezuru Ezu Baa? Olu - Is everyone rich? No." "Omumu si na Chukwu - To have children is a gift from God." "Ochu Okuko Nwe Ada" is a typical Igbo parable. The lyrics explain that a person who chases a chicken will always fall but the chicken will never fall. If you plot against an innocent person you'll hurt yourself in the end. "Nwa nkpe ya na Eze gbaru mkpe, nwa mkpe atagbuela onye ya na afufu - If a widow gets into a conflict with a King, she will suffer much." The song calls on the Messiah, the one who made a blind person to see and a cripple to walk. Finally, the song "Elu Uwa Were Obi Oma" calls on the people of the world to be kind to get their just rewards:
Obi Wuru Otu Dance Group of Ihiagwa-Owerri - Olum Ado Ogu-Ezuruezuba/Ochu Okuko Nwe Ada/Elu Uwa Were Obi Oma-AFA Nna Na Nwa
Many thanks to my wife Priscilla for translating the lyrics of this record. Download Nwanyi Ma Obi Diya, complete with scans of the album sleeve, here. I have a couple more albums by the Obi Wuru Otu Dance Group, and will probably post them in the future.
Sunday, January 24, 2010
The Ladies of Ihiagwa-Owerri
Posted by John B. at 7:24 PM 9 comments
Labels: Igbo, Igbo Traditional Music, Nigeria, Nigerian Female Vocalists, Obi Wuru Otu Dance Group, Rose Nzuruike
Subscribe to: Posts (Atom)


text:
The good, the bad . . .
In the afterglow of a 3-1 triumph and three-game weekend sweep of the Blue Jays . . .
With two outs in the sixth, Erick Aybar still on second after a leadoff double, Hideki Matsui unloads on a Ricky Romero fastball and sends it rocketing one-hop off the center-field wall to snap a scoreless deadlock for Ervin Santana. Before the game, manager Mike Scioscia talked in some detail about how Japanese hitters spend hour after hour trying to gain a perfect balance at home plate. At times it appears Matsui is leaning back as he takes his swing, falling away, but he manages to keep his bat in the hitting zone and drive the ball. He did it again in the ninth, igniting what proved to be an important two-run rally. This is an amazing hitter, a man who thrives under pressure.
These sparse, disinterested Blue Jays crowds. I know it's Stanley Cup time, and it's cold, and the Jays haven't been good for a long while, and they traded Roy Halladay. But this is not good. I've always defended Canadian baseball fans, and I truly miss Montreal, one of the world's great cities. But the Jays aren't that bad. These "Lyle" chants, zeroing in on the slumping first baseman, are not worthy of such an urbane city. The Jays drew for these three Angels dates what they once attracted for an average regular-season game. Sad.
Ervin Santana, when he's on his game, is a tremendous pitcher. He was dealing with supreme confidence from the outset Sunday. Trouble surfaced twice in the early going, and both times he reached back and made quality pitches, leaving runners in scoring position. His fastball was sitting in the 91-93 mph range – not quite where it will be when he gets in a warm-weather groove – and his slider and changeup were dancing. He thought his change was his best pitch, and he should know. If he maintains his rhythm, flow and confidence, the Angels could have a rotation full of All-Star candidates after a rough first two spins through the cycle. – Lyle Spencer
2 Comments
As the season was ready to start, I thought we had a solid lineup 1 – 9 plus a really good starting pitching staff. I had some doubts about our relief corp and although I'm not a big fan of Fuentes, he did do a decent job last year. I still think that relief pitching will haunt us throughout the season and I'll bet that Rodney is the closer by mid season.
Of course I was bummed that we got off to such a bad start, but you're not out of the playoff race after the first week or two of the season (except if you're Baltimore). It looks like the skipper has the ship on the right course and the team is stepping up. On offense, we're all worried about Wood. He seems to be a perenial minor league player and it's already to the point where the Angels are going to need to make a decision on what to do at third base.
As for catcher, we're hearing a lot of grumbling in the L.A. times how having three catchers is not good for team moral and its a matter of time before Napoli is on his way out.
I think Ervin has the best stuff on this staff! My grandma certainly loves him :D. We always joke around in our house that my grandma's favorite player is not Chan Ho Park (we're korean) it's Ervin Santana.. and erick aybar …. she also is very fond of Joe Girardi but that's a whole nother story! Let's just say we are passionate about baseball in our house
Rogers Centre looked so empty 😦


text:
Delivery by Thu 3rd Dec 10hrs 55 mins left
Free delivery over $100
Free 100-day returns and express refunds
We price match, and carbon offset deliveries
"Kronstadt began when designer Thomas Olesen decided there weren't enough 'funky shirts' in Scandinavia. The brand has since introduced more discreet designs, focusing on fit, high quality and classic cuts that will bring Scandi style to your look."
Brand: Kronstadt
Category: Knitwear & Sweaters > Zip, shawl & fastened jumpers
Colour: Navy
Delivery to any US address using FedEx or UPS. Usually takes 3-6 business days.
Free for orders over $100, or $7.99.
All import duties paid.
Order before 5AM Wednesday for delivery to a US home address. Usually takes 2 business days.
Just $11.99.
Note: all items in the order must qualify for the service
Once your order is dispatched we'll email you instructions for making a return.
Measured from the date you receive the box to the date you hand it back to a returns partner. Read our full returns policy here.
Johan Small Check$74$37
Kit - Cropped$79$40
Lee - Cropped$79$20
Need help? Contact our team
97% of emails answered in two hours or less


text:
No Results Found
We could not find any properties for your chosen search.
Why not try increasing the search radius to include properties in the nearby area?
Need help finding the correct postcode? Why not use the Royal Mail Postcode Finder?
Thinking of selling or renting your property?
Get a instant valuation today!
Marketed by:
Country Holmes, Glossop
18 High St West
Tel: See phone number 01457 761310
Website: Go to Agent Website


text:
Turn me up (feel me like) let me get a feeling of who love me
And who I love (that's what it's all about though)
You understand?
First you got to know how to move (the forecast calls for...)
Then you got to know how to make moves (straight up)
All y'all
It's eternal (what?)
(We getting on the ninety five?) Yea I like that word
(Yo) we bringing it from here (don't drive too close to the ?heava? nigga)
Understand? (Come on) let's go let's go let's go
Yea that's right (right)
What up? So what is it called? (you know what its called kid)
Yo (how much I, how much I implement my thoughts to you?)
Yo, hey yo shout out New York
Philadelphia my sword talk
Praises due
The block favors you
New Jers with the guerillas with the most sexiest birds
Vehicles and shit shout out your word
Fox premier
My niggas in Connecticut yea
Upstate, Albany got love here
Rochester all the way down to stretcher
You large Long Island niggas definitely paint a picture
Chicago peace
Maryland take cheese
Baltimore lock it all down yo lets increase
Boston stay flossing
My eye like Steve Austin
Seeing how y'all bought Rae fortune
Texas yo
How many lexuses y'all goin' flow
Yall niggas doing it is love yo
Miami and North Carolina like family yea
Spoil a nigga like kids with cotton candy
Yo Va. all the money makers generate
Shorty driving around still making ten a day
L.A. yep its real when they tell me
Yep I know it's ill 'cause police tried to kill me
And oh let's politic and make dido
D.C. I hope y'all feel me when I ble-do
Atl., Tennessee ring bells
Out in Ohio bumping twenty inch wheels
Yea San Franciso, Vegas, Illinois, Dallas
Minneapolis cats rap with us
Michigan yea Rollie Derm burn
Phoenix, Sacramento really care
Bitches on the air
Portland, Buffalo, Toronto
Stay Brolic in the Giants like the Denver Broncos
Yo South Carolina bring the drama
Still in all like the way she ball
Yea she yelling she my baby mama
Japan coma
London, Germany, China holla
Africa my brother
Russia light a dutch up
Indiana where they all throw scramblers and they cut ya'
Jamaica yep Bahamas
And we honor everything
Looking Guyanese in Ghana
Detroit saying go head do your thing boy
Puerto Rico come on through Raekwon my boy!
Louisiana and Canada
St. Louis, Florida you're on what? Candid Camera
He like master in Nebraska
Fleeing in white mink on god G-ing in Alaska
Laid up Brazil play real
Got like fifty K in a briefcase Rae'll chill
What? You know the plan
Laying up in Amsterdam
Blowing nine grand
Batting a white man
Oooooo tell me it's me you want baby
Got to tell me
Why don't you tell me girl?
Tell me its me you want baby...
Ha ha ha ha...


text:
Dear 4Life Distributor,
In the last few years, the Italian market has experienced great growth, thanks to the hard work of our Distributors. I'm excited to implement changes to the Italian compensation plan that were announced during the recent Europe Convention: Together 2019. These changes will be effective on April 2. The updates will help align Italy with other international markets.
Along with changes to the Italian Life Rewards Plan™, the Italian Builder Bonus will have new requirements that will be leveraged by the three pillars of enrollment, duplication, and retention. Plus, we will launch our new, exclusive "Io vinco!" (I Win!) incentive to help new Diamonds and Presidential Diamonds in Italy get recognized and grow their businesses in 2019.
You can read more about the changes by visiting our italian dedicated section on 4lifetools.eu. I am confident that the new changes will boost the Italian business and the monthly qualifications.
Thank you for joining with us in Together, Building People through science, success, and service.
Best regards,
Rafael Fernández
European Vice President
4Life Research
You are trying to view a MyShop page. Please log out in order to view this website.


text:
It's a rarer occurrence that spotting bigfoot riding the Loch Ness monster, but Grace Digital Audio has just announced a speaker dock designed specifically for the Kindle Fire. You read that right, the FireDock won't even acknowledge the iPad's existence.
Instead of the Apple dock connector included on 99.99 per cent of the speaker docks available on the market, the $US130 FireDock (available come July) will instead connect to the Kindle Fire's headphone jack and USB port at the same time. So while you're enjoying your music or streamed media blasting through the dock's 16-watt speakers, your tablet will also be charging.
The FireDock also accomodates the Kindle Fire's bottom-mounted power button so you can turn the tablet on and off when it's docked, and its mount can be rotated for using the tablet in landscape or portrait orientations. What's that? You say you've got other devices you'd like to connect? Well unlike Panasonic's latest addition, the FireDock includes an aux-in port for connecting whatever you want. [Grace Digital Audio]


text:
The QRZ Help FAQ
Frequently Asked Questions about QRZ
Please note: if you're having some sort of problem, it would be very kind of you to read this document carefully before asking someone for help.Topic Index
How Do I Login?
The following general rules apply to QRZ user accounts.
Changing your Password / Account Preferences
How do I change my password?
How do I put my picture online?
About the Database, and the FCC
How often do your update your FCC data?The Online Swap Meet
How do I place an ad in the online swapmeet?Can't find it here?
Don't forget to search through the Help Center Forum where hundreds of people can help you with your problem.


text:
Telstra has partnered with Chinese OEM ZTE to bring to market two new 4G smartphones in time for Christmas, the telco announced today.
Both the Telstra Frontier 4G and the Telstra Easy Touch 4G will go on sale this month. The devices are manufactured by ZTE but feature prominent Telstra branding.
The pair of Android smartphones are targeted at price conscious consumers, though the telco has stressed that its brand has a strong trust within the consumer market.
"We have a huge number of customers on Telstra branded devices, in fact there's an enormous amount of trust in the Telstra brand and Telstra branded devices that we're putting into the market," said Telstra's director of device management, Andrew Volard.
The Telstra Frontier 4G is the first 4G-capable prepaid smartphone to hit the market in Australia, while the Telstra Easy Touch 4G is designed for first time users. Both devices run Google's Android 'Ice Cream Sandwich' mobile operating system.
The Frontier 4G has a 4in touch screen, is powered by a 1.5GHz dual-core processor and has a 5-megapixel camera with LED flash.
The Easy Touch 4G features large icons, on-screen guides and custom designed shortcut menus designed to assist users who may be unfamiliar with the Android operating system. It has a 4.3in display and an 8-megapixel camera.
The Telstra Frontier 4G will retail for $299 when it officially goes on sale from Tuesday 27 November, while the Telstra Easy Touch 4G is available from today outright and unlocked for $456.
The release of both the Easy Touch 4G and the Frontier 4G follow the release of Telstra's own branded, 4G-capable Android tablet, the Telstra 4G Tablet, last month.


text:
Samsung promises slimmest-ever phone LCD
- 22 November, 2006 09:34
Samsung Electronics has developed what it claims is the thinnest LCD (liquid crystal display) panel, just the thickness of a credit card, designed for use in mobile phones.
The screen measures 0.82 millimeters thick and, combined with a new method for attaching the panel to devices, will allow manufacturers to shave between 1.4 mm and 2.4mm off the thickness of their phones, Samsung said.
The size reduction comes partly from a new assembly technology developed by Samsung called i-Lens. Most phone screens use a piece of reinforced plastic that sits a few millimeters above the LCD to protect it. With iLens, Samsung found a way to attach a protective sheet directly onto the display in a way that also improves its shock resistance and readability.
The technique makes the display easier to read outdoors because it eliminates the reflection that occurs on the plastic sheet used in existing designs, Samsung said.
The screens will be available in 2.1 inch and 2.2 inch diagonal sizes. They offer 240 x 320-pixel resolution and 500:1 contrast ratio. Samsung expects to be mass producing them by the second half of next year.
Since the popularity of Motorola's very thin phones, including the Razr, phone makers are increasingly trying to make thinner phones. The Razr flip phone is 13.9 mm thick.


text:
Hello everyone !
This is Sameer. I am from India, I am a CNC machine engineer and also a hobbyist. Like to learn new things related to computers and electronics and experiment with them. I hope to learn lot more by joining you all and i would be glad, if i would able to help someone.