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77564: Shub-Niggurath, Black Goat of the Woods with a Thousand Young
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By Kangaroorex
2020 has-been rough on everyone but some people have had it rougher than others. A friend of mine is disabled and has had a really hard time just trying to keep basic necessities done.
I thought I would send her a little friend who's got simpler an cuter problems. Purple is her favorite color. He goes out in the mail on Monday
Hope you like him too...
By Chris Palmer
Back when the Bones 4 Kickstarter was running, when the Giant Rhinoceros Beetle was revealed in the Fan Favorites set, someone posted this photo of a Frog riding a Beetle to the Enthusiasm Thread, and I knew it was a conversion I would eventually want to try. I have an extensive Frog Army, and I wanted such a figure to be a Leader or Hero for my forces.
I had the pieces I needed at hand; the Bones Black "Giant Rhinoceros Beetle", and my rider - for which i had decided to use the Bones "Mudcroak" Squog figure.
As I looked at Mudcroak, I knew I would have to separate him from his base, but I knew there was no way I could remove all those little toes from the base without damaging them. So, right off the bat I made the decision to just remove his feet along with the base, with the plan that I would then resculpted them with greenstuff directly onto the beetle's back once I had the frog glued in place.
Here's a test fit, with the frog held in place with blue-tac.
That's all for right now.
By Bane Of Humanity
Ok, this may have been asked before and I have a terrible memory and I could not find a straight answer in the FAQ.
The white material vs the slightly less white material (not to be confused with bones black)
I have a what is essentially a bucket of bones miniatures from all 4 kickstarters. Im a slow painter.
I decided to pick a few out to paint. I painted Almaran the gold and noticed his head was deformed. replaced it
Next I tried Durok the dwarf ranger and I noticed his right side did not mold correctly. Nothing I could do about it but its fine not complaining.
Ive noticed most of my bones 4 that had the new grey material have not had these sort of issues.
I would show pics but I dont wanna...
My question is has this issue been fixed for the older bones miniatures, Are they being cast in this new grey material?
By Iridil
This was a quick, and fun, paint - I have a soft spot for the translucent figures - painted up as a 'gift' from an NPC to my players. Just open the box for help....
By Kuroneko
I think most GM's can sympathise, sometimes your players just get lucky going through a dungeon. Maybe the dice are on their side or maybe they're just a bunch of min/maxing little murder hobos that have destroyed everything in their path. What you need is one final encounter, one last way to try and salvage at least some of your pride and show them that they're not quite as in control as they think they are.
There's a room. It's certainly locked and probably warded and what player can resist that? Once they force their way the find this ancient stone circle. There's some sort of mossy ooze growing on its base, but the players attention is drawn to the softly pulsing light from the giant cabochon jewels set as eyes in the carved dragon heads. How can they resist?
A massive thanks to @TaleSpinner for sculpting such an awesome piece, it was a pleasure to paint!
This is when you turn around the portal What comes out of it? Not sure, but its certainly something draconic, maybe even something with 5 heads
Thanks for looking, all comments and criticisms are gratefully received. Hope you liked it.
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Take a chance: Live Arts hosts acoustic show
I've got something to admit, but you can't tell anyone. I've not actually heard any of the bands playing at this week's previewed show. But before you call for my immediate removal from the esteemed Hook writer pool, let me say this– presenting unfamiliar local acts, many without any published recordings to speak of, is the central point of the now seven-years running Acoustic Charlottesville.
Started by local musicians in 1997, Acoustic Charlottesville has been providing a space for the Charlottesville songwriters to come out and show their wares. The artists perform on the first Saturday of every month from September to December– a mixture of big name locals and new kids on the block. Sal Milione has taken over as producer of AC and is actually one of the artists performing at the October 5 show.
Milione explained, "We implicitly recruit new acts by saying, 'Hey... you don't need a professional recording for Acoustic Charlottesville to consider you. Just play song of your songs well, into a boom box if you have to... and send it to us.'" Not quite what a person who is paid to analyze music and then tell you, the reader, what shows to check out in town, likes to hear.
Acoustic Charlottesville received two demos from artists performing at next Saturday's show, but these were requested and given for solely "Acoustic Charlottesville hears." Acoustic Charlottesville believes this policy "gives the opportunity for great players to perform at a great venue without necessarily having a professional recording. The audience ends up getting new and diverse performers," which Acoustic Charlottesville considers a key component into what makes the showcase a success.
This month's shows performers are Josh Mayo– giving us some "pop/rock" stylings ( of the local rock act Paul Goes Richter), Blue O'Connell– a songwriter of "intelligent and spiritually acoustic songs," Sara Reed and Rob Greenway, past members of the group "Roaring Mary," playing some Irish traditional music, and Donald Aielli, performing songs that blend "contemporary jazz, blues, folk, classical and Spanish rhythms."
Sometimes you gotta take a leap of faith when deciding what to do with your Saturday night, such as checking out a band merely because they have a cool name, or because you respect the booker of the club in question. With a six-year track record behind it, odds are the shows that make up the seventh year of Acoustic Charlottesville will expose us to at least one or two local stars of the future, as well as providing an eclectic experience for your a few of your Saturday nights.
Acoustic Charlottesville presents Josh Mayo, Blue O'Connell, Sara Read and Rob Greenway, and Donald Aielli at Live Arts Space LAB on Sepetember 7. $5, 8pm.

subset: commoncrawl


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I'm working on this idea, and I don't know if it appeals to you guys. I'd like your input on whether this is something to explore further.
Here's the deal: I've encountered teams who, when working with SOA technologies have been dragged into the mud by the sheer complexity of their tools. I've only seen this in Java, but I've heard from some C# developers that they recognize the phenomenon there as well. I'd like to explore an alternative approach.
This approach requires more hard work than adding a WSDL (web service definition language. Hocus pocus) file to your project and automatically generating stuff. But it comes with added understanding and increased testability. In the end, I've experienced that this has made me able to complete my tasks quicker, despite the extra manual labor.
The purpose of this blog post (and if you like it, it's expansions) is to explore a more bare-bones approach to SOA in general and to web services specifically. I'm illustrating these principles by using a concrete example: Let users be notified when their currency drops below a threshold relative to the US dollar. In order to make the service technologically interesting, I will be using the IP address of the subscriber to determine their currency.
step 1: create your active services by mocking external interactions
Mocking the activity of your own services can help you construct the interfaces that define your interaction with external services.
[sourcecode language='java']public class CurrencyPublisherTest {
private SubscriptionRepository subscriptionRepository = mock(SubscriptionRepository.class);
private EmailService emailService = mock(EmailService.class);
private CurrencyPublisher publisher = new CurrencyPublisher();
private CurrencyService currencyService = mock(CurrencyService.class);
private GeolocationService geolocationService = mock(GeolocationService.class);
public void shouldPublishCurrency() throws Exception {
Subscription subscription = TestDataFactory.randomSubscription();
String location = TestDataFactory.randomCountry();
String currency = TestDataFactory.randomCurrency();
double exchangeRate = subscription.getLowLimit() * 0.9;
verify(emailService).publishCurrencyAlert(subscription, currency, exchangeRate);
public void setupPublisher() {
Spoiler: I've recently started using random test data generation for my tests with great effect.
The Publisher has a number of Services that it uses. Let us focus on one service for now: The GeoLocationService.
step 2: create a test and a stub for each service – starting with geolocationservice
The top level test shows what we need from each external service. Informed by this and reading (yeah!) the WSDL for a service, we can test drive a stub for a service. In this example, we actually run the test using HTTP by starting Jetty embedded inside the test.
[sourcecode language='java']public class GeolocationServiceStubHttpTest {
public void shouldAnswerCountry() throws Exception {
GeolocationServiceStub stub = new GeolocationServiceStub();
stub.addLocation("18.104.22.168", "Norway");
Server server = new Server(0);
ServletContextHandler context = new ServletContextHandler();
context.addServlet(new ServletHolder(stub), "/GeoService");
String url = "http://localhost:" + server.getConnectors()[0].getLocalPort();
GeolocationService wsClient = new GeolocationServiceWsClient(url + "/GeoService");
String location = wsClient.getCountryByIp("126.96.36.199");
validate and create the xml payload
This is the first "bare-knuckled" bit. Here, I create the XML payload without using a framework (the groovy "$"-syntax is courtesy of the JOOX library, a thin wrapper on top of the built-in JAXP classes):
I add the XSD (more hocus pocus) for the actual service to the project and code to validate the message. Then I start building the XML payload by following the validation errors.
[sourcecode language='java']public class GeolocationServiceWsClient implements GeolocationService {
private Validator validator;
private UrlSoapEndpoint endpoint;
public GeolocationServiceWsClient(String url) throws Exception {
this.endpoint = new UrlSoapEndpoint(url);
validator = createValidator();
public String getCountryByIp(String ipAddress) throws Exception {
Element request = createGeoIpRequest(ipAddress);
Document soapRequest = createSoapEnvelope(request);
Document soapResponse = endpoint.postRequest(getSOAPAction(), soapRequest);
return parseGeoIpResponse(soapResponse);
private void validateXml(Document soapMessage) throws Exception {
protected Validator createValidator() throws SAXException {
SchemaFactory schemaFactory = SchemaFactory.newInstance(XMLConstants.W3C_XML_SCHEMA_NS_URI);
Schema schema = schemaFactory.newSchema(new Source[] {
new StreamSource(getClass().getResource("/geoipservice.xsd").toExternalForm()),
new StreamSource(getClass().getResource("/soap.xsd").toExternalForm()),
return schema.newValidator();
private Document createSoapEnvelope(Element request) throws Exception {
return $("S:Envelope",
$("S:Body", request)).document();
private Element createGeoIpRequest(String ipAddress) throws Exception {
return $("wsx:GetGeoIP", $("wsx:IPAddress", ipAddress)).get(0);
private String parseGeoIpResponse(Element response) {
return null;
private Source toXmlSource(Document document) throws Exception {
return new StreamSource(new StringReader($(document).toString()));
In this example, I get a little help (and a little pain) from the JOOX library for XML manipulation in Java. As XML libaries for Java are insane, I'm giving up with the checked exceptions, too.
Spoiler: I'm generally very unhappy with the handling of namespaces, validation, XPath and checked exceptions in all XML libraries that I've found so far. So I'm thinking about creating my own.
Of course, you can use the same approach with classes that are automatically generated from the XSD, but I'm not convinced that it really would help much.
stream the xml over http
Java's built in HttpURLConnection is a clunky, but serviceable way to get the XML to the server (As long as you're not doing advanced HTTP authentication).
[sourcecode language='java']public class UrlSoapEndpoint {
private final String url;
public UrlSoapEndpoint(String url) {
this.url = url;
public Document postRequest(String soapAction, Document soapRequest) throws Exception {
URL httpUrl = new URL(url);
HttpURLConnection connection = (HttpURLConnection) httpUrl.openConnection();
connection.addRequestProperty("SOAPAction", soapAction);
connection.addRequestProperty("Content-Type", "text/xml");
int responseCode = connection.getResponseCode();
if (responseCode != 200) {
throw new RuntimeException("Something went terribly wrong: " + connection.getResponseMessage());
return $(connection.getInputStream()).document();
poiler: This code should be expanded with logging and error handling and the validation should be moved into a decorator. By taking control of the HTTP handling, we can solve most of what people buy an ESB to solve.
create the stub and parse the xml
The stub uses xpath to find the location in the request. It generates the response in much the same way as the ws client generated the request (not shown).
[sourcecode language='java']public class GeolocationServiceStub extends HttpServlet {
private Map<String,String> locations = new HashMap<String, String>();
public void addLocation(String ipAddress, String country) {
locations.put(ipAddress, country);
protected void doPost(HttpServletRequest req, HttpServletResponse resp) throws ServletException, IOException {
try {
String ipAddress = $(req.getReader()).xpath("/Envelope/Body/GetGeoIP/IPAddress").text();
String location = locations.get(ipAddress);
} catch (Exception e) {
throw new RuntimeException("Exception at server " + e);
Spoiler: The stubs can be expanded to have a web page that lets me test my system without real integration to any external service.
validate and parse the response
The ws client can now validate that the response from the stub complies with the XSD and parse the response. Again, this done using XPath. I'm not showing the code, as it's just more of the same.
the real thing!
The code now verifies that the XML payload conforms to the XSD. This means that the ws client should now be usable with the real thing. Let's write a separate test to check it:
[sourcecode language='java']public class GeolocationServiceLiveTest {
public void shouldFindLocation() throws Exception {
GeolocationService wsClient = new GeolocationServiceWsClient("http://www.webservicex.net/geoipservice.asmx");
Yay! It works! Actually, it failed the first time I tried it, as I didn't have the correct country name for the IP address that I tested with.
This sort of point-to-point integration test is slower and less robust than my other unit tests. However, I don't find make too big of a deal out of that fact. I filter the test from my Infinitest config and I don't care much beyond that.
fleshing out all the services
The SubscriptionRepository, CurrencyService and EmailService need to be fleshed out in the same way as the GeolocationService. However, since we know that we only need very specific interaction with each of these services, we don't need to worry about everything that could possibly be sent or received as part of the SOAP services. As long as we can do the job that the business logic (CurrencyPublisher) needs, we're good to go!
demonstration and value chain testing
If we create web UI for the stubs, we can now demonstrate the whole value chain of this service to our customers. In my SOA projects, some of the services we depend on will only come online late in the project. In this case, we can use our stubs to show that our service works.
Spoiler: As I get tired of verifying that the manual value chain test works, I may end up creating a test that uses WebDriver to set up the stubs and verify that the test ran okay, just like I would in the manual test.
Taking the gloves off when fighting in an soa arena
In this article, I've showed and hinted at more than half a dozen techniques to work with tests, http, xml and validation that don't involve frameworks, ESBs or code generation. The approach gives the programmer 100% control over their place in the SOA ecosystem. Each of the areas have a lot more depth to explore. Let me know if you'd like to see it be explored.
Oh, and I'd also like ideas for better web services to use, as the Geolocated currency email is pretty hokey.


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Folks, I'm tired. Literally exhausted – as opposed to metaphorically exhausted. Although I suppose that there is a a little from the later as well. However, I was up most of the night with a toothache last night and so if I seem slightly incoherent or completely off my rocker, it's because I'm pretty much fueled on 100% caffeine right now. I am also craving a calzone, but have no clue where to obtain said desire from my office. Anyhow, let's move on to the musings, shall we?
On Raiding
We are currently working through out last Hard Mode – Heroic Ascendant Council. And I'm going to be brutally honest here, I've about had it with the fight. To the point that I almost don't even care if we kill the damn thing. And here's the kicker – our failing is 100% our lack of execution in phase 2. I find that I'm completely out of words to say to people short of "please just stop fucking up and pay attention to what is going on around you, because if you fail this mechanic one more time, I swear to christ I'm going to reach through my monitor and chew your ass in person".
I mean, I'm at a loss. The second phase of the encounter is 100% about personal responsibility – and there is no one that can control that aside from the player responsible. And it's frustrating the ever living hell out of me. And you know what, I'm going to just go ahead and say it: phase 2 of this fight is just fucking stupid. There. That felt pretty good. I get that fights should be challenging – and I enjoy that. But there gets to be a point where too much is too much, and encounters cross the line from fun and a "challenge" to ridiculous and frustrating.
I feel that this encounter has reached that point. Any fight where one person's error can irreversibly fail your raid, is not fun. It's just not. Should there be consequences for failing a mechanic? Yes. Should the failure of one individual cause the entire raid to end up on their ass, and running back for another attempt? No. I do think that consequences should be devastating – but I also think that you should have at least a chance, even if it's tiny, to succeed with strong teamwork should an error occur. It is not fun for the person struggling with the mechanic (and knowing they were the reason the raid wiped), nor is it fun for the raid.
Not only that, but with Firelands breathing down our neck, I'm feeling incredibly pressured to push us through this monstrosity of a fight (pun intended, har). And to continue being honest, it's taking its toll on me and I've found myself not only growing increasingly negative – but becoming a person that I don't like in the process. After last night's raid, I literally needed to step back and re-ground myself. Remind myself of my own goals, who I am as a person – and how I want to be as a leader.
I'm all ears if anyone has tips or tricks they use to keep people from blowing each other up during Phase 2. Lord knows I'm neck deep in frost orbs and chain lightning right now.
On Recruiting
We have a couple of spots open on our progression roster, so I thought I'd just bring your attention to that here (after that fabulous rant on raiding…). We currently have an opening for a hunter and a resto shaman. I would also consider a warlock applicant. If you are interested in applying or learning more about the guild, please visit http://www.monolithwow.com or feel free to shoot me an email with any questions that you might have about the guild.
On Alts
My mini-me, Elentari, hit 85 this weekend. I had a whole slew of gear ready for her that I had been saving up and having crafted. I was able to enter into heroics as soon as I reached 85 – however my first (and only, to date) venture was an experience. I ended up having to have Brade hop into come tank for us after a paladin tank really struggled with, well, tanking. I drew heroic deadmines – and for the life of me couldn't figure out why a relatively undergeared tank refused to use CC, especially when he was clearly struggling with controlling the mobs that he was trying to tank.
I am hoping that Elentari will be able to get some raid time, if not now when 4.2 hits and the T11 content is nerfed and more puggable. It's been a lot of fun revisiting the struggles of being an undergeared resto druid, and I'm looking forward to learning more about my playstyle through her errors!
What alt is next? Who knows. I've been toying with the idea of going back to my rogue goblin that I started at the beginning of Cataclysm. I've also toyed with dusting off my shaman or priest. Or perhaps it's time to take my worgen druid through a spin and see the new alliance starter zone.
On Other Games
Brade and I picked up Portal 2 this weekend, and I spent a few hours entertaining myself with that. However, I will admit that I became somewhat irritated as we played the game and he was just blazing through puzzles miles faster than I was. I pretty much made me feel like an idiot as I struggled with this he clearly found simple. I know, I know – brains work differently and all that, and I'm sure there were some puzzles that just clicked for me that took him a bit longer.
But I began to grow flustered as I was trying to keep up at his pace, and just couldn't. I mean I was the one who wanted the damn game in the first place, and I found myself wishing that he hadn't picked up a copy because his quicker success was spoiling my enjoyment (regardless of how insane that may sound). So I took a step back and just let him go. I found when I came back and he was 20 boards ahead of me and not 5, it was much easier for me to enjoy the game at my own pace and struggle through the puzzles in a more relaxed manner.
And now, I'm working my way through with an insane eyeball and some robot that seriously has it out of me. And it's a lot of fun! I don't know if/when I'll try the co-operative play, because of my early frustration is "playing" with Brade, but perhaps we will see how it pans out.
On Books
So I finished the War of the Ancients Trilogy and I absolutely loved it. Although I found myself hollering across the house "What the hell happened to Azshara!" upon my completion. I mean, I know that she was turned into a Naga. But really, we've not seen her again since. (I am having serious Deja'vu here – so if I've already had this conversation, my apologies!)
I took a break from the WoW lore to crack open the new Sookie Stackhouse book, and I really enjoyed it. It wasn't the best in the series, but it was far from the worst as well. So I was pretty pleased with it.
I am not reading some of the Harry Dresden shorts in preparation for his new book coming out in July. I cannot wait! I really enjoy Jim Butcher's writing, and I've yet to read one of the books in this series that wasn't a page turner. To say I have high hopes is an understatement!
I think that's about all I've got for now! How about you, what have you been up to?


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Helensville Sand Plant
Lance GoslingWinstone AggregatesHelensville Sand Plant
Available Hours
- Weekdays 7.00AM - 4.45PM
- Saturday 7.00AM - 12.00PM
Physical Address
Postal Address
Core Products: Sand
Helensville Sand plant is located on the shores of the Kaipara Harbour, New Zealand's largest estuary complex. The operation extracts sand for the production of concrete products and civil construction applications.
See Helensville Sand Plant feature on North with Marcus Lush


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Things are desperate aboard the Moneywinds it seems.
All those spectacular seminars by the world's most voracious "FSM's" do not appear to be doing the trick. Nor the "how to make money" seminars from CO FSSO and her crew who cannot generate enough income to buy the fuel to sail out of port.
So, they are trying to get people there with give-aways. It tells you everything you need to know about the state of the "Top of the Bridge" of scientology that they have to try and entice people to get others to arrive — with a SPECIAL AWARD for OT VIIIs that can be conned into going to the ship to the do the PURIF and OBJECTIVES.
How is it that with the spectacular and unprecedented, straight up and vertical, 63X, massive international expansion there isn't anyone arriving at the TOP of the Bridge? Why is the ship not filled to the gunwales with people on OT VIII with a line waiting on the docks for space to free up? Why is it that every other org is booming, and this org, designed to accommodate the flow of OT VIIIs in 1988 has not needed to expand? In fact, they cannot fill a single course room or seminar.
Nobody seems to comment on this. It seems that people ONLY go to the Moneywinds for the Maiden Voyage celebration and they manage to get 250 people rounded up for that week to hobnob with the COB. I guess they must assume the place is like that the rest of the time. Sort of like believing the Indianapolis International Speedway has 250,000 people in it every day of the year.
This issue reeks of desperation.
If scientology has the answers to all life, and OT VIII is the ULTIMATE achievement in scientology and first TRUE OT Level, people should be falling all over themselves to get it. It is FAR more important than if someone had come up with a cure for cancer. Or even a new iPhone.
Somehow, the reality isn't even in the same ballpark as the hype.


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Hello all! I am majoring in Studio Art at Oklahoma State University and I wanted to open up the possibility of doing custom portraits for you all again. I need to keep myself busy working and could also use the extra income to help support Toby. I am very interested in doing some in charcoal instead of graphite and unfortunately, I don't have any examples of my work in charcoal in my gallery yet. I can still do pencil, though, and I'm even open to doing scratchboard (a few older pieces can be seen in my gallery).
GALLERY: http://thecountess.deviantart.com/
I really need to update this, pieces will be coming in over the next few weeks.
I am only taking THREE commissions right now, due to time constraints. However, I'm also cutting my price in half. I've typically gotten paid $70-80 for 8 x 10 portraits on paper. Instead, I'm dropping my price to $40. I just sold a custom scratchboard (8 x 10) for $125, but I'll drop that price to $60. These prices are only valid to the first three people that want a commission (IF I get that many! Haha).
I can also mat works done on paper for you before I mail them, making them easy to fit into a common sized frame. I will do this for an extra $10, which around here is a pretty common price for this size of work if you go have it done somewhere.
If you're interested, please respond to this thread.


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Link zu Esther
Since 07/01/2013
In Ethiopia, two thirds of all cancer patients are women, and out of these, almost half are affected by cervical cancer. The latency for cervical cancer is between 10 – 20 years with about 4 years of symptomatic disease. Therefore, considering that an estimated 10.000 new cases occur yearly in Ethiopia, each living with the disease for 20 years, a total of 200.000 women are affected. This includes early stages without any symptoms and more advanced stages with bleeding, infections, severe pain, as well as anemia and eventually incontinence and renal failure.
Prevention of HPV infection as well as access to cervical cancer screening for early detection and access to treatment is an important pre-requisit for improved health of women. The partnership contributes to improvement in all three areas and provides evidence of the relevance to the Ministry of health through data gained by operational research.
Martin Luther University
Medical Faculty Department of Gynaecology
Halle, Germany
Radiotherapy Center and Department of Gynaecology and Department of Pathology and School of Public Health
Cervical cancer awareness and prevention strategies are presented as recommendations to the Federal Ministry of Health for policy development and access to services for cervical cancer patients in the catchment area of the university hospital of Addis Ababa is improved.
1. Evidence is generated for awareness and prevention strategies according to the risk factor profile of cervical cancer in the context of NCDs.
2. HPV prevalence in normal population and genotypes of cervical cancer patients are estimated and population based incidence rates are established in selected areas.
3. Histo-technicians and gynaecologists at AAU are better qualified to offer cervical cancer diagnosis and treatment.
4. Radiotherapists are upgraded and certified.
■ Capacity Strengthening
■ Operational Research
■ Prevention
Outcome Indicator 1:
HPV prevalence and genotypes as well as cervical cancer incidence have been established and documented and strategies for awareness creation have been elaborated.
Outcome Indicator 2:
Number of women affected searching cervical cancer treatment is increased by 20% within the project period of 2 years.
The ESTHER partnership started in July 2013.
Im Rahmen ihrer Facharztweiterbildung sollen die Gynäkologen einmal eine deutsche Klinik kennenlernen. Die Kollegen aus St. Paul, einem der größten Krankenhäuser in Addis Ababa, haben die Reise selbst organisiert und waren nun in 3 Gruppen je eine Woche in Halle. Sie haben viele Einblicke bekommen, im Operationssaal, bei den Sprechstunden und auf der Station hospitiert.
Diese 7 Ärzte werden in den nächsten Jahren die Betreuung der kommenden Weiterbildungsassistenten übernehmen und so ihr Wissen weitergeben.
Lesen Sie die Berichte der Kollegen!
weitere Links
Das Bundesministerium für Bildung und Forschung (BMBF) fördert die Forschungskooperation mit Afrika: Krebserkankungen der Frau in Äthiopien" - Medizinische Fakultät der Martin-Luther-Universität Halle-Wittenberg mit der Addis Abeba Universität


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Rights Contact Login For More Details
More About This Title Polypharmacology in Drug Discovery
- English
An essential outline of the main facets of polypharmacology in drug discovery research
Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide:
Covers the two-sided nature of polypharmacologyits contribution to adverse drug reactions and its benefit in certain therapeutic drug classes
Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles
Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology
Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology
A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
- English
Jens-Uwe Peters, PhD, works in the Medicinal Chemistry Department at F. Hoffmann-La Roche. In his ten years at Roche, he has been involved in numerous drug discovery projects, has contributed to Early Safety Profiling initiatives, and has researched opportunities for polypharmacological drug discovery. Dr. Peters is author or coauthor on twenty-six journal papers and is named on twenty-two patents.
- English
Introduction: the case for polypharmacology
Andrew L. Hopkins
Part A: Polypharmacology – a safety concern in drug discovery.
1 The relevance of off-target polypharmacology
Bruce D. Car
2 Screening for safety-relevant off-target activities
Laszlo Urban, Steven Whitebread, Jacques Hamon, Dmitri Mikhailov and Kamal Azzaoui
2.1 Introduction.
2.2 General aspects.
2.3 Selection of off-targets.
2.4 In silico approaches to off-target profiling.
2.5 Summary and conclusions.
3 Pharmacological promiscuity and molecular properties
Jens-Uwe Peters
3.1 Introduction: pharmacological promiscuity in the history of drug discovery.
3.2 Lipophilicity.
3.3 Molecular weight.
3.4 Ionisation state.
3.5 Other molecular descriptors and structural motifs.
3.6 Implications for drug discovery.
4 Kinases as antitargets in genotoxicity
Stephan Kirchner
4.1 Protein Kinases and inhibitor-binding sites.
4.2 Cyclin-Dependent Kinases (CDKs) controlling unregulated cell proliferation.
4.3 Mitotic kinases as guardians protecting cells from aberrant chromosome segregation.
5 Activity at cardiovascular ion channels: a key issue for drug discovery
Ian M. Bell, Mark T. Bilodeau and Armando A. Lagrutta
5.1 Introduction.
5.2 Screening methods.
5.3 Structural insights into the interaction between drugs and CV ion channels.
5.4 Medicinal Chemistry approaches.
5.5 Conclusion.
6 Prediction of side effects based on fingerprint profiling and data mining
Jacques Migeon
6.1 Introduction to BioPrint.
6.2 The pharmacological fingerprint.
6.3 Antidepressant example.
6.4 Profile similarity at non-therapeutic targets.
6.5 Interpreting the polypharmacology profile.
6.6 Methods.
6.7 Patterns of activity.
6.8 Integrating function profile data with traditional pharmacological binding data.
6.9 Analysis of the antifungal tioconazole.
6.10 Conclusions.
Part B: Polypharmacology – an opportunity for drug discovery.
7 Polypharmacological drugs – "magic shotguns" for psychiatric diseases
Wesley K. Kroeze and Bryan L. Roth
7.1 Introduction.
7.2 Definition.
7.3 The discovery and extent of promiscuity among psychiatric drugs.
7.4 Why are so many psychiatric drugs promiscuous?
7.5 Conclusions.
8 Polypharmacological kinase inhibitors: new hopes for the therapy of cancer
Annalisa Petrelli
8.1 Targeted therapies: a new era in the treatment of cancer.
8.2 The single-targeted therapy.
8.3 From single to multi-targeted drugs in cancer therapy.
8.4 Polypharmacology kinase inhibitors in clinical practice and under development.
8.5 Concluding remarks.
9 Polypharmacology as an emerging trend in antibacterial discovery
Lynn L. Silver
9.1 Introduction.
9.2 Classical antibacterial polypharmacology.
9.3 New approaches to multi-targeted single pharmacophores.
9.4 Synthetic lethals.
9.5 Hybrid molecules.
9.6 Conclusions.
10 A "magic shotgun" perspective on anticonvulsant mechanisms
Matt T. Bianchi and Kathy Chuang
10.1 Introduction.
10.2 Anticonvulsant mechanism.
10.3 Defining promiscuity.
10.4 Promiscuity: lessons from endogenous signaling.
10.5 Promiscuity: lessons from anticonvulsant electrophysiology.
10.6 Use of anticonvulsants in disorders other than epilepsy.
10.7 Experimental and theoretical support for a "Magic Shotgun" approach.
10.8 Current multi-target strategies.
10.9 Practical considerations.
10.10 Conclusion.
11 Selective Optimization of Side Activities (SOSA): a promising way for drug discovery
Thierry Langer and Camille-Georges Wermuth
11.1 Introduction.
11.2 Definition and principle.
11.3 Rationale of SOSA.
11.4 Establishing the SOSA approach.
11.5 A successful example of the SOSA approach.
11.6 Other examples of SOSA switches.
11.7 Discussion.
11.8 Computer-assisted design using pharmacophores.
11.9 Conclusions.
Part C: Selected approaches to polypharmacological drug discovery
12Selective multi-targeted drugs
Richard Morphy
12.1 Introduction.
12.2 Lead Generation.
12.3 Lead optimization.
12.4 Case studies.
12.5 Summary.
13 Computational multitarget drug discovery
Jeremy A. Horst, Adrian Laurenzi, Brady Bernard and Ram Samudrala
13.1 Introduction.
13.2 The pharmacologic hunt of yesteryear.
13.3.Established technological advancements.
13.4.Computational drug discovery.
13.5.Recent technical improvements.
13.6.Emerging concepts.
13.7 Summary.
14 Behavior-based screening as an approach to polypharmacological ligands
Dani Brunner, Vadim Alexandrov, Barbara Caldarone, Taleen Hanania, David Lowe, Jeff Schneider and Jayaraman Chandrasekhar
14.1 The Challenges of CNS Drug Discovery.
14.2 In vivo high throughput screening.
14.3 Screening libraries of compounds.
14.4 Relationship between molecular properties and in vivo CNS activity.
14.5 Following screening hits in secondary assays.
14.6 Potential therapeutic value of dual adenosine compounds.
14.7 Summary.
15Multicomponent Therapeutics
Alexis A. Borisy, Grant R. Zimmermann and Joseph Lehár
15.1 Introduction.
15.2 Drug synergies are statistically more context dependent.
15.3 How a synergistic mechanism can lead to therapeutic selectivity.
15.4 Discussion.
Part D: Case studies
16 The discovery of sunitinib as a multitarget treatment of cancer
Catherine Delbaldo, Camelia Colichi, Marie-Paule Sablin, Chantal Dreyer, Bertrand Billemont, Sandrine Faivre and Eric Raymond
16.1 A brief introduction to tumor angiogenesis.
16.2 The discovery of sunitinib: from drug design to first evidences of clinical activity.
16.3 Pharmacology of sunitinib.
16.4 Safety of sunitinib.
16.5 Activity of Sunitinib.
16.6 Surrogate imaging techniques to capture vascular changes.
16.7 Surrogate biomarkers.
16.8 Conclusion.
Claus Riemer
17.1 Definition and diagnosis of schizophrenia.
17.2 Etiology and pathophysiology of schizophrenia.
17.3 Epidemiology.
17.4 Medical practice and treatment options.
17.5 Case studies.
17.7 Conclusions.
18 Triple Uptake Inhibitors ("Broad Spectrum" Antidepressants)
Phil Skolnick
18.1 Introduction.
18.2 What is the rationale for developing triple uptake inhibitors as antidepressants?
18.3 Preclinical data.
18.4 Clinical data.
18.5 Concluding remarks.
19 Therapeutic potential of small molecules modulating the cyclooxygenase and 5-lipoxygenase pathway
Stefan Laufer and Wolfgang Albrecht
19.1 Targets of the eicosanoid pathway.
19.2 Rationale for development of dual inhibitors of the cyclooxygenase and 5-lipoxygenase pathway.
19.3 Dual inhibitors of the cyclooxygenase and 5-lipoxygenase pathway.
19.4 Development of Licofelone.
19.5 Conclusions.
20Drug research leading to imatinib and beyond to nilotinib
Paul W. Manley and Jürg Zimmermann
20.1 Introduction.
20.2 Historical background.
20.3 BCR-ABL1 as the molecular target for CML therapy.
21 Towards antimalarial hybrid drugs
Bernard Meunier
22 Multitarget drugs for the treatment of Alzheimer's disease
Andrea Cavalli and Maria Laura Bolognesi
22.1 Introduction.
22.2 Case studies.
22.3 Conclusions and perspectives.
23 Carbonic anhydrases: off-targets, add-on activities, or emerging novel targets?
Claudiu Supuran
23.1 Introduction.
23.2 Carbonic anhydrase inhibition.
23.3 Topiramate and zonisamide, antiepileptics with potent antiobesity action.
23.4 Sulfonamide coxibs with antitumor activity due to CA IX/XII inhibition.
23.5 Sulfamates with steroid sulfatase and carbonic anhydrase inhibitory action as anticancer agents in clinical development.
23.6 Lacosamide, an antiepileptic with a strange binding mode to Cas.
23.7 The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian CA isoforms.
23.8 Conclusions.
- English
"The book is well presented and the price is reasonable for anyone (drug designers, medicinal chemists, biochemists, biologists, clinicians and toxicologists) interested in any of the many facets that come together to make polypharmacology." (British Toxicology Society, 1 July 2013)
"However, anyone interested in the complex issues relating to drug promiscuity should find this very timely and topical book to be a reliable and stimulating reference that they will revisit many times." (ChemMedChem, 2012)
"Only recently, the characterization of promiscuous ligands turned from 'dirty drugs' into 'agents being rich in pharmacology.' … Polypharmacology in Drug Discovery covers all aspects, the good, the bad and the ugly. On the one hand, a lack of specificity (the 'bad') causes more or less serious side effects; inhibition of certain antitargets (the 'ugly'), e.g. the hERG channel, results in a termination of a development project, in the past even the withdrawal of already marketed drugs; on the other hand, a desired promiscuity (the 'good') may be beneficial, e.g. in the case of certain CNS drugs and of anti-tumor kinase inhibitors. In Peters' book, all these topics are discussed in great detail by internationally leading authors. Therefore, Polypharmacology in Drug Discovery is of utmost importance for all drug designers, medicinal chemists as well as biochemists and biologists. The price of the book is in excellent relationship to its 500 pages and the overall quality, in content and presentation."—Prof. Dr. Hugo Kubinyi


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I would appreciate it if you had the integrity to name or notify the five trouble makers so they can knowingly correct there actions .
It is possible they dont realise there behaviour is causing such trouble .
If you choose not to do so in public , may i suggest a PM .
They may be totally oblivious , and think there contributing to the forums , after all truth is relative .
A word to the wise , all will be remembered for your actions by the lurkers , all the wanting in the world does not make a situation so , the truth is not relative , respect peoples intelligence to see any hidden agenda .
If any part of my message breaches froum rules/ettiquite , please let me know and I`ll gladly modify it .


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I really thing the p25 give you an excelent imagess and you should not look the cost, and you should not look the cost of p45 either. I pay $46,00.00 for a van as to much for my house. Why not to spend 30 plus for something the you like and wil be using and maybe get your money back?BlasR[a href=\"index.php?act=findpost&pid=57880\"][{POST_SNAPBACK}][/a]
Seeing the world though ones own restricted experience is, regretably, one of the failings of many in our society.
LOL, and I thought my sensor brush was expensive! [a href=\"index.php?act=findpost&pid=57928\"][{POST_SNAPBACK}][/a]
I slightly regret my off-hand comment about my wife being 'speechless' if I casually trotted out and blew $30,000 on something I don't particularly need for my business.[a href=\"index.php?act=findpost&pid=57928\"][{POST_SNAPBACK}][/a]


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Hello Good People who read this blog…. ( this was written between around 10pm and 2 a.m.on the night of the London-wide riots)
If you are like me, living in London, what a night! I am in a relatively peaceful area but there's been a strong smell of smoke coming into my living room since early evening, sirens, the odd scream. I don't think there is much going on my way but hearing about Ealing and now Camden, well it could all "kick off" here too, it could "kick off" anywhere in any disillusioned British town.
I am not at all surprised at the riots, no matter what the media people and politicians say, it is not purely due to just looting or just about one guy killed by the police. I do not think this rioting and looting would have happened if it wasn't for many factors, including school holidays. How can they not expect trouble sooner or later? After all we have had the politicians ripping us off with their expenses, the bankers ripping us off massively and throwing us into a global recession while most of them still live a life of luxury, the entire global economy has collapsed since Thursday again..and then all the scandal about Rupert Murdoch's media empire and corrupt policemen, corrupt politicians….ridiculously expensive University fees suddenly imposed on a whole generation, massive cuts suddenly imposed on a whole generation without warning…well I am not surprised, why would anyone be surprised that we are having riots.
What do these rioters have to lose? They are already being punished before they even started to cause trouble. Prison is probably not that much of a threat compared to a life of poverty for many young people, having been brought up with the idea that materialism is everything.
Meanwhile all those moneyed politicians were quite happy to stay on their posh holidays and it's only now that the crisis is absolutely Londonwide that they are moving their arses, pathetic lot!
But to any young person reading this I say :
"Enough already, you are burning your own town, your are hurting your own people, destroying the homes of your friends, families, and neighbours. You may feel disconnected from everything but you are not, everything is cause and effect . You are special but you need to change things to make things better not worse!"
British society is just f****d. I don't like capitalism,or conventional lifestyles, but …use your brains! This is going to ruin us all, who is going to want to come here and employ you next summer?
I saw Ken Livingstone speak on the BBC News and I have to say that I agree with the things that he said. Ken will always be a hero for trying to abolish fares on public transport and for being a pain in the neck to Margaret Thatcher, even though I also remember seeing Ken promising the London Irish Community that if they elected him as mayor that he would make St. Patrick's day a national Holiday,which I found very weird at the time, much like Boris saying he'd get rid of bendy buses. If you don't come from London none of this will mean anything to you.
But although I am just another alienated urban dweller, I do feel that this is my town, and I don't like to see it go up in smoke.
Hippie ideals were political, were/are rebellious but at the heart of it all was collaboration, love and peace, simple.
You can achieve so much more by not wrecking things but by creating things.
But I feel that this is just part of the chaos going on generally and on this I will do one of my personal rants:
Last Thursday and Friday before the rioting, I experienced a series of strange incidents that demonstrated how stressed, angry and impatient Londoners were. For instance, on Friday I nearly got run over by a large Tesco truck who was reversing round a corner, on the pavement. He saw me but reckoned I could probably jump out of the way. I did but only just.
Later I was in a catholic church, yes a church, I know this may sound weird but I had my reasons, and during the mass these two women of a ripe old age were having a loud row, claiming one of them had pinched her seat while at communion, well they were kind of shouting in loud whispers, at the back of the church. But I have never seen a row in a church like this while a mass was taking place.I put it down to the heat, the economic cuts and general stress.
The next day in the afternoon before the riots started, I was in a Tesco supermarket (yes bad me, how ironic after nearly getting killed by one of their trucks ) ,I was calmly minding my own business when a woman tried to pick a fight with me. She was not crazy, but was deliberately standing in the middle of a limited space and was stopping people from getting past her, i.e. me. I said "sorry" no less than three times to get her to move but she didn't budge, so I ever so gently, edged my way past her, and she started to pick a fight with me. She shouted to me that:
"English people say 'excuse me' not 'sorry' if they want someone to move." I soon left the shop after I realised she was determined to have a row with me, she probably thought I was a tourist. I decided to go home because everyone seemed so stressed, and then I witnessed three more incidents on my way home.
OK, so it was crowded and it's summer, but I could really sense that there was more tension in London than usual. One of the next incidents was in a little garden/children's area. A young man was shouting aggressively at this two year old boy, who he didn't know, and then the man burst into tears, leaving the toddler and his mother bewildered and upset. I then saw the man sitting on a bench rocking slightly to and fro, his girlfriend was rubbing his back and consoling him. He also did not look like he was mentally ill, he looked like an average "respectable" bloke, but maybe everyone is just cracking up under all the global economy meltdown and so many changes and strange events worldwide. As he was being consoled by his girlfriend, the mother and toddler were left to themselves, clearly shaken and distressed.
So I think these riots that are taking over London and perhaps the country are part of this general chaotic reaction to many stressful and oppressive events.
How is it that people are surprised that there are a load of young people miserable, willing to go to jail, and going mad?This is how people are feeling after being told they won't get an education, or a job, or a pension, that their library will close down that everything will be harder and harder. But also young people have had 20 or 30 years of being brainwashed that all that matters is money, sex, what you look like and in particular what objects you can buy that will get you ahead in life or make you feel better about life.
You only have to look at the T4 presenters on Channel 4 , to know that a whole generation have nothing but shallow, trite, crap to aspire to.
The police implore "know where your children are and ask them to come home" , but why the hell don't you know what your children are doing anyway???? Don't you ever spend time with your children or talk to them?
Some music now, something peaceful, not a typical piece of hippie music, but a modest example of how some popular 70s idealism helped to change mindsets. I think first you have to change your mindset, if you are strong enough, and then put it into action to change the world.
Cat Stevens ( BBC Theatre 1971).
I hope that London can be rebuilt, not just the homes, the shops, the streets, but a soul , a collective heart, a willingness to care for one another, to leave behind our screens and desks and to face one another honestly.
I think we are going to see a lot more protest of one sort or another , we have so much monitoring, self-monitoring, outside monitoring, and rules and more rules to make everything in life that might be free or good, complicated and exhausting. Everything in our British society in 2011 seems to assume, that everyone is a criminal. A criminal before proven innocent. I'd like to be able to go somewhere and help tomorrow, help someone, another Londoner who I don't know, but I can't because I don't have a recent CRB check. I might be a pervert or I might be doing voluntary work when also claiming benefits, or I might be this or that……………..It p*****s me off because most of us are not criminals yet all of us are treated that way, it makes everything ten times more complicated than it needs to be and everything ten times less satisfying to do.
If you treat teenagers like they cannot be trusted and have to be monitored all the time, guess what? They'll prove you right and start playing up and rebelling and doing all the things you dread. As citizens we are not treated like responsible adults able to make responsible and useful acts and decisions. Don't get me started!!!!
I am almost sure we will have a curfew soon, except the government will want to look good and not oppressive, so maybe they won't bring in a curfew. Even as a hippie I actually would be scared if we had a curfew because I want to feel that I am not living under siege, but I could also understand that if parents really don't know where their children are, and London is going is going to be burnt to the ground that a temporary curfew might be a good thing until people calmed down a bit. I never thought I would write that!
So let's hope somehow young people can find another way, collaborate with one another, but still kick up a fuss.
We are in a terrible financial situation and this society needs to totally reinvent itself. Labour is f****d ,the Conservatives are f****d, the other ones are also f****d.
These stupid political parties are so intent on looking good that their leaders are ineffectual insipid thunderbird puppets, and not in any way credible as leaders with brains ( I don't mean "brains" the thunderbird puppet). As a slightly older person I see these political leaders as being students at suburban comprehensive secondary school, like the one I went to in south London, which is probably being burnt to the ground as I speak, or write.
Ed Milliband is the harmless naive, gormless first year student, in his school blazer, he still doesn't know how to knot his tie. Ed's mother bought his school uniform from John Lewis, it is two sizes too big, she hopes that he might grow into it one day. His big brother doesn't want to be seen with Ed in the playground during break time , but sometimes he comes to Ed's rescue when he is being bullied for his lunch money.
Nick Clegg is the student teacher in English, he gulps with tension, as he faces his class for the first time, with a sweaty forehead and clammy palms. The head of the English department always gives student teachers the most difficult classes to teach. No one ever listens to poor young Clegg. Maybe once he went into teaching with high ideals to change the world and educate all, but he soon found himself towing the line, having to follow the national curriculum, thinking about the league tables, regardless of their usefulness in children's real education.
Lastly we have the Head Boy,such a good boy, David Cameron.
Cue music…Kevin Coyne – Good Boy ( 1973 from the album Marjorie Razorblade).
David ( Cameron) the head boy , likes to earn points for his house. His mother's au pair, gives him a fresh hankerchief and irons his tie every morning and if it isn't done properly the au pair is reprimanded, she also has to make him a fresh organic packed lunch so that he doesn't have to sit with the poorer pupils with dribbling noses who get school dinners. David knows he is better than the rest. He is in Clegg's class but intimidates him. David and his best friend the dim but jovial "Bozo" Boris, sit in the back of the class, sniggering while exchanging little notes about Clegg written in Latin. They both know that they do not belong with the masses in this comprehensive school, and will help one another up the social ladder once at University.
But who is the headteacher??? Or should I say who is the Head Mistress of this school? It is of course Theresa May, in her imagination, she likes to pretend she is Supreme Commander Servalan of Blakes 7 , as she rules. She has the brains and the gravitas to put all these silly little boys in their place.
Servalan ( Theresa May's role model ) and Blakes 7
Anyway…on a more serious note , I dread to see how much damage there will be in London once the smoke clears and the sun comes up. All the time I have been typing this, I have had the BBC News in the background, it's windy outside and the smokey air is still blowing in through my living room window, sirens are heard in the distance from time to time. I'm not sure 24 hour news coverage is helping matters, young people want to be famous, it is encouraged in every way by endless reality TV shows, so I wouldn't be surprised if some of them relish seeing themselves on TV.
Before I go I'd like to leave you with some music from my good friend Frobischer Neck. He has done a wonderful cover of this track by the German band Neu! with some great Mellotron arrangements. Enjoy!
I wish all of you in London ( and elsewhere) Peace and Safety, hoping some inner wisdom could gently guide the next generation in a better way and inspire them to hope and build an alternative world instead of just destroying the old one.


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Happiness 101
Published: January 21, 2007
As a retired teacher of humanities and English, I thought at first that D. T. Max's article (Jan. 7) described a good way to help students connect with meaning and a desire to do good. But it's hard to see positive psychology as entirely worthwhile
if it values happiness ''at the cost of a full understanding of literature and human complexity.''
Nancy Tilly
Chapel Hill, N.C.
Mark Linkins seems to be describing an established scientific or philosophical truth, as Max quotes him: ''It's preferable to be happy than not, even if that means the potential for creative output is diminished.'' The logic in his astonishing assumption makes a compelling argument for lobotomies.
Robert Edwards
Swarthmore, Pa.


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text: Injulen 1 Posted July 6, 2012 (edited) Hey all. Did some service today and figured I would snap some photos and do a quick write up. I had a CEL code P0440, that one has something to do with the EVAP system leaking. After weeks of searching for the cause and scratching my head, today I finally found it. Where the fill vent goes through the frame rail near the passenger side rear tire, the metal pipe simply rusted away. I had already checked my fill pipe a few times since that is one of the most common causes of the P0440 code but this little piece escaped my eye for quite awhile!! One of the worst things was that I couldn't put more than 1/2 a tank of gas in the vehicle without getting a horrendous headache inducing gasoline fume smell. Once I found where the fumes were leaking out, I despaired a little. It was a kind of a pain in the butt spot and I couldn't find that part for sale anywhere without buying the whole filler neck assembly for $100+. Enter my step-dad: he recently repaired his truck's filler neck with some 1 1/4" copper pipe. He showed me his repair work and we decided to give the same concept a go on the Subaru. Scrounged up some 5/8 OD copper tubing, cut & bent a piece, voila!! No more fume smell, no more CEL!!!!!! Oh, and it cost me $0. Free labor and a piece of scrap copper. Imgur Album: http://imgur.com/a/k05np Car is jacked up and ready to go. The smaller diameter pipe on the right is the one that rotted through. These "Before" images are actually from a '95 Legacy, I forgot to take photos before doing the work to my '97 Legacy. Close up of where the vent pipe goes through the frame. The plastic grommet extends through the frame and trapped a lot of dirt and moisture, causing the pipe to rust right through. This is the other side of the frame rail where the vent pipe ends and connects to the rubber vent hose that goes to the gas tank. The hardest part of this service was getting up in there to unhook that clamp. On my '97 Legacy there are three hoses that aren't on this '95 which go to the charcoal canister. (The '95 has the canister under the hood instead of behind the rear passenger wheel) You can see that the pipe is quite corroded and swollen from the rust. I was able to grab on and wiggle it quite a bit. The part of the pipe that is visible on the outside of the frame rail wasn't moving whatsoever so I knew there was a break inside the frame. After pulling out the filler neck and vent assembly, here is the rusted out vent pipe and the grommet it runs through. You can clearly see that the worst of the rust happened right inside the protective grommet. Pic without the grommet. Nasty. Here you can see my tungsten carbide ring is nice and shiny despite the road grime xD 5/8" OD copper tubing. Bent it to shape and size, wrapped some electrical tape to bump up the OD for a snug fit, went together smoothly. I accidentally broke the bolt that holds the vent pipe bracket and filler neck to the chassis but oh well. Zip ties are in my future! Will probably also stuff some cloth or rubber around the copper pipe so it doesn't rub too much against the frame. In this pic you can actually see the three black rubber hoses that come to and from the charcoal canister. They are visible in the bottom left of the photo. One last note, this was made much easier by removing the filler neck tube. It wasn't completely necessary but it opened up a lot of maneuvering space for my hands. Edited July 6, 2012 by Injulen More Photos Share this post Link to post Share on other sites


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