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SAMJ: South African Medical Journal
versión On-line ISSN 2078-5135
versión impresa ISSN 0256-9574
SAMJ, S. Afr. med. j. vol.101 no.5 Pretoria may. 2011
Prevalence of drug-resistant mutations in newly diagnosed drug-naïve HIV-1-infected individuals in a treatment site in the Waterberg district, Limpopo province
Julius NwobegahayI; Pascal BessongII; Tracy MasebeI; Lufuno MavhanduI; Cecile ManhaeveIII; Norbert NdjekaIV; Gloria SelabeV
IMSc. AIDS Virus Research Laboratory, Department of Microbiology, University of Venda, Thohoyandou, Limpopo Province
IIPhD. AIDS Virus Research Laboratory, Department of Microbiology, University of Venda, Thohoyandou, Limpopo Province
IIIMA. The HIV/AIDS Prevention Group, Bela-Bela, Limpopo Province
IVMD. The HIV/AIDS Prevention Group, Bela-Bela, Limpopo Province
VPhD. HIV/AIDS and Hepatitis Unit, Department of Medical Virology, University of Limpopo, MEDUNSA Campus, Garankuwa
AIM: We studied the prevalence of resistance mutations in drugnaïve HIV-infected individuals at the Bela-Bela treatment site to gather information on the presence of antiretroviral (ARV) drug-resistant viruses in drug-naïve populations, so as to improve treatment guidance.
SUBJECTS AND METHODS: Drug-naïve HIV-1-infected individuals were sequentially recruited between February 2008 and December 2008 from individuals visiting the voluntary counselling and testing (VCT) services of the Bela-Bela HIV/AIDS Wellness Clinic. Viral subtyping was done by phylogenetic analysis; drug-resistant mutations were determined according to the Stanford HIV Drug Resistance Interpretation and the International AIDS Society-USA Guidelines.
RESULTS: A drug-resistant mutation prevalence of 3.5% (95% confidence interval 0.019796 - 0.119077) comprising Y181C and L33F was observed; 98% of the viruses were HIV-1 subtype C on the protease (PR) and reverse transcriptase (RT) gene regions.
CONCLUSION: The prevalence of drug-resistant mutations in drugnaïve persons may be low in Bela-Bela after 8 years of access to antiretroviral treatment (ART), and resistance testing before initiating treatment may not be needed.
Highly active antiretroviral therapy (HAART) has dramatically reduced morbidity and mortality among HIV/AIDS patients. However, a major drawback of HAART is the development of drug resistance.1,2 South Africa has a high HIV prevalence, and access to treatment is expanding. A regimen based on the genetic resistance profiles of patients' viruses before initiating therapy generally correlates with a better outcome, compared with the absence of such resistance data.2 The emergence of drug resistance in drug-naïve populations should be monitored, particularly in regions such as Limpopo Province, where such data are scarce. We aimed to determine the prevalence of ARV drug-resistance among drug-naïve HIV-infected individuals in a community where treatment has been provided for a considerable time.
Study subjects were recruited from the HIV/AIDS Wellness Clinic in Bela-Bela, Waterberg District, Limpopo Province. Treatment at the clinic began in 2001. HIV-positive individuals without prior exposure to ARV were recruited sequentially between February 2008 and December 2008. Five ml of venous blood was collected into EDTA vacutainer tubes from each consenting subject. Demographic data were obtained by questionnaire administration. Viral RNA was isolated using the viral mini RNA kit (Qiagen). Viral DNA was synthesised by a one-tube reverse transcription-polymerase chain reaction (RT-PCR), followed by a nested PCR.3 The PCR products were verified for expected size by electrophoresis of 1% agarose gel. PCR amplicons were purified with a QIAquick PCR purification kit (Qiagen), and direct population-based sequencing was performed on both strands. HIV subtyping was done by phylogenetic analysis. Predicted amino acids for the PR and RT genes were aligned using the BioEdit programme (http://www.mbio.ncsu.edu/BioEdit/bioedit.html). Owing to the broad scope of viral mutations, drug-resistant mutations were identified using the Stanford HIV Drug Resistance Interpretation Algorithm (http://hivdb.stanford.edu/) and the International AIDS Society (IAS)-USA Guidelines.4 Two algorithms were used to describe as broadly as possible the significance of observed amino acid substitutions. The Bayesian analysis was used to calculate the 95% confidence interval (CI), to estimate the confidence limits around the prevalence estimate. The PR and RT gene sequences reported here have been submitted to GenBank with the following respective accession numbers: PR [GU139577-GU139633] and RT [GU139634-GU139688]. Approval of the study protocol was obtained from the Health, Safety, and Research Ethics Committee of the University of Venda, Thohoyandou.
A total of 79 HIV-infected individuals were sequentially recruited. The mean age was 43.5 (18 -69) years. The most important risk factor for HIV transmission was sexual intercourse (88.6%), but the questionnaire was not designed to determine whether this was heterosexual or homosexual. In 90% of the cases the most probable place of HIV infection was South Africa. Viral DNA was obtained for 62 out of 79 (78%) individuals. Reliable nucleotide sequences were obtained for 57 PR genes and 55 RT genes. Using the Stanford and IAS guidelines, major drug-resistant mutations were detected in 2 out of 57 subjects (3.5%) (95% CI 0.019796 - 0.119077). One primary NNRTI mutation (Y181C) and one major PI mutation (L33F) were detected in two different patients. No primary NRTI mutation was recorded. The detected mutations, nucleotide substitution, and their potential significance are shown in Table I.
Phylogenetic analysis of the PR and RT genes showed that 56/57 (98.2%) of the isolates were HIV-1 subtype C on both gene regions. One isolate (08BBVCT31ZA) was HIV-1 subtype B on the PR and RT genes (phylogenetic trees not shown). Mean genetic distance for the PR sequences ranged from 0.0101 to 0.2035 and 0.0331 to 0.1377 for the RT sequences. Considering the first 300 amino acids in the RT gene, sequence alignment showed that the consensus sequences of the test viruses were identical to the global subtype C consensus, except at 2 positions (V60I and Q174K). The consensus sequence differed from the global subtype B consensus at 17 positions (V35T, E36A, T39E, S48T, V60I, K122E, D123G, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, and T286A). Amino acid alignment of the PR gene showed that the test consensus was identical to the global subtype C consensus, except at position I13T. It differed from the global subtype B consensus at 8 positions (T12S, I15V, L19I, M36I, R41K, H69K, L89M, and I93L).
The development of drug resistance is an important attribute of HIV biology. An inevitable drawback of HAART is the emergence of drugresistant variants in patients under treatment, which complicates treatment options and hampers good prognosis. Antiretroviral therapy was started at the Bela-Bela Wellness Clinic about 8 years ago, within which time resistance could have possibly emerged. The low rate (3.5%) of drug-resistant mutations detected in this study is similar to reports in other parts of South Africa. Drug-resistance studies among naïve patients reported a prevalence in Gauteng Province in 2002 and 2004 of 4.2%;5 in Cape Town of 2.5%;6 and 3.6% in Free State Province.7 Low levels (<5%), or the absence of drug-resistant mutations, have been reported in Zambia8 and Malawi.9 Higher rates have been reported in several developed countries with more than a decade of ART history.10,11
Low rates of ARV drug resistance are expected in developing countries because most patients start therapy on highly potent regimens, unlike in the developed world where ART scale-up began with resistance-associated monotherapy and one-class dual therapy. In this study, one primary NNRTI mutation (Y181C) was observed (Y181C mutation causes high-level resistance to nevirapine and delavirdine and low-level resistance to efavirenz), while no primary NRTI mutation was noted. This mutation occurred in a 40-year-old married woman. At the time of the investigation, the South African national drug regimen guideline stipulated the use of stavudine, lamivudine and efavirenz as first-line therapy for those who had never been exposed to ARVs, with nevirapine replacing efavirenz for women of child-bearing age.12 It is not clear whether the patient who harboured the Y181C mutation had been enrolled in a motherto-child transmission prevention programme in which nevirapine was used.
One major PI mutation (L33F) was detected. This mutation is classified as a major mutation by the Stanford Drug Resistance Interpretation Algorithm, and as a minor mutation by the IAS-USA guidelines (L33F mutation is selected by fosamprenavir/ritonavir, duranavir/ritonavir, lopinavir/ritonavir, atazanavir/ritonavir, and tipranavir/ritonavir, and contributes to resistance to these drugs).
This study indicates that the prevalence of drug-resistant HIV among the drug-naïve population in Bela-Bela is low after 8 years of free ART. We used population-based sequencing in our study, which might have contributed to an underestimation of drug-resistance prevalence. Patients may harbour populations of minor-resistance viruses that are usually not detected by population sequencing. This prevalence study also used chronically infected patients, which could mean that resistance acquired might have disappeared over time, which might have also led to an underestimation of the results.
Apparently, the testing of patients for drug-resistant viruses before initiation of therapy may not be required. However, subsequent periodic studies are required in Bela-Bela and other treatment sites to monitor the emergence and spread of drug-resistant viruses. Such data are important for guiding policy on sentinel surveillance and treatment algorithms. A high prevalence could indicate the need for regular sentinel surveillance or for baseline genotypic drug-resistance testing before treatment.
This study was supported by a research grant awarded to PB by the South African National Department of Health, under the Comprehensive HIV and AIDS Care, Management and Treatment Plan for South Africa. Financial support from the National Research Foundation is also acknowledged. PB, NN and CM are board members of the HIV/AIDS Prevention Group, an NGO running the Bela-Bela Wellness Clinic. The views expressed here are those of the authors.
1. Gatanaga H, Ibe S, Matsuda M, et al. Drug-resistant HIV-1 prevalence in patients newly diagnosed with HIV/AIDS in Japan. Antiviral Res 2007;75:75-78. [ Links ]
2. Turner D, Wainberg MA. HIV transmission and primary drug resistance. AIDS Rev 2006;8:17-23. [ Links ]
3. Bessong PO, Mphahlele J, Choge IA, et al. Resistance mutational analysis of HIV type 1 subtype c among rural South African drug-naive patients prior to large-scale availability of antiretrovirals. AIDS Res Hum Retroviruses 2006;22(12):1306-1312. [ Links ]
4. Johnson VA, Brun-Vezinet F, Clotet B, et al. Update of the drug resistance mutations in HIV-1. Topics HIV Med 2009;17(5):138-145. [ Links ]
5. Pillay V, Ledwaba J, Hunt G, et al. Antiretroviral drug resistance surveillance among drug-naïve HIV-1infected individuals in Gauteng province, South Africa in 2002 and 2004. Antivir Ther 2008;2:101-107. [ Links ]
6. Jacobs GB, Laten A, van Rensburg EJ, et al. Phylogenetic diversity and low level antiretroviral resistance mutations in HIV type 1 treatment-naïve patients from Cape Town, South Africa. AIDS Res Hum Retroviruses 2008;1009-1012. [ Links ]
7. Orrell C, Walensky RP, Losina E, Freedberg KA, Wood R. HIV-1 Clade C resistance genotypes after first virological failure in a large community ART programme. J Int AIDS Soc 2008;11:1758. [ Links ]
8. Handema R, Terunuma, H, Kasolo F, et al. Prevalence of drug resistance associated mutations in antiretroviral drug naïve Zambians infected with subtype C HIV-1. AIDS Res Hum Retroviruses 2003;19:151-160. [ Links ]
9. Kamoto K, Aberle-Grasse J. Surveillance of transmitted HIV drug resistance with the World Health Organization threshold survey method in Lilongwe, Malawi. Antivir Ther 2008;2:83-87. [ Links ]
10. Cane P, Chrystie I, Dunn D, et al. Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study. BMJ 2006;21:179-180. [ Links ]
11. Taiwo B. Understanding transmitted HIV resistance through the experience in the USA. J Inf Dis 2008;10:1-8. [ Links ]
12. Department of Health. National Antiretroviral Treatment Guidelines. Pretoria: Department of Health, 2004. [ Links ]
Accepted 18 October 2010.
Corresponding author: P Bessong (email@example.com)


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Posts Tagged 'cramps'
If men could menstruate … clearly, menstruation would become an enviable, boast-worthy, masculine event: Men would brag about how long and how much. … Sanitary supplies would be federally funded and free. Of course, some men would still pay for the prestige of such commercial brands as Paul Newman Tampons, Muhammad Ali's Rope-a-Dope Pads, John Wayne Maxi Pads, and Joe Namath Jock Shields — "For Those Light Bachelor Days."
Gloria Steinem
IF men could menstruate, I wouldn't have to frickin' BEG my goddam gynecologist for a total hysterectomy.
He'd have KNOWN, instinctively, to just go ahead and yank my plumbing from my gaping C-sectioned abdomen after he extracted the TWO-FOOT-LONG infant from my womb seven years ago.
Perhaps, IF men could menstruate, Dr. Doogie Houser would have — if not empathy — surely, SYMPATHY, for the fact that I SUFFER from retrograde menstruation and Stage IV endometriosis.
Perhaps, IF every month, in addition to experiencing a two-week crimson tide, Dr. Doogie ALSO had menstrual waste forced back up through his fallopian tubes to spill out into his abdominal cavity, he would give me the radical overhaul for which I beg.
Perhaps, IF Dr. Doogie had to endure just one 'Butt-Kink', as I fondly call it, wherein all of that menstrual waste material adhering to his intestines and sphincter feel as if someone has yanked them UP and held TAUT for a minute or two — perhaps, THEN, (after he is able to catch his breath and let every muscle in his very body relax) — THEN — he GLADLY would extract my female parts.
Instead, even before I can finish my HYSTER-ical plea, he is already shaking his head, saying, "No. No. No. You're too young."
Why is it men are all-too happy to stuff shit IN to your nether regions,
but they never wanna take anything OUT?
My only consolation: I think Dr. Doogie's a Buddhist. I pray he comes back as a WOMAN. And then to another man.
Until then, I'm stuck with another 15-20 years of menstruation.
And that's another thing that pisses me off: Shouldn't it be 'WOMENstruation'?
For crissake, even on that, WE get the GORY and THEY get the GLORY?
Recently, my pre-pubescent daughter asked me, "Mommy, if you had THREE WISHES, what would they be?"
Without hesitation, I fired off:
#1 That every man in the world would POOF! into a woman.
#2 That I would become the HEARTLESS BITCH GYNECOLOGIST to those new women.
#3 That Sir James Dyson would invent an affordable VagiVac so all the REAL WOMEN of the world could frickin' suck out their own uteri in the comfort of their own homes whenever they damn-well feel like it.
Okay, well, maybe those three wishes were what I said in my head. Maybe I said 'world peace' to m'kid. Maybe. (I hope.)
But don't get me wrong. I didn't refrain from blurting out my REAL three wishes because I didn't want to curse in front of the kid.
I just wanted to PROTECT her from THE PERIOD — period.
I want to protect her from THE CURSE and all of its nasty, negative effects, in general. I want to protect her from the visceral urge to slice up every male living thing on the face of the earth every 28 days.
How I DREAD my babygirl's imminent entrance to womanhood! How my heart breaks at the thought of the loss of her happy, innocent, worry- and pain-free childhood. How sorry I am that she is a SHE; how sorry I am that she must heft the burden of being female.
Now, don't get me wrong; I don't necessarily hate womanhood. On the contrary, I know I was made a woman because women are the stronger of the sexes; I don't care what anybody thinks or says. Hell, if The Big Guy thought for a millisecond that MEN could handle childbirth and MENses, He'd've given the Grand Prize to THEM. I'm just pissed that guys have all the fun and get all the breaks — in every way, shape and form.
And don't even try to sell me that SHIT about how men are the ones who have to bring home the bacon and support a family, 'cause I'm not buyin'.
Most women I know hold down full-time careers AND do ALL 1) childcare 2) housework 3) shopping 4) cooking 5) bill-paying 6) yardwork 7) help with homework 8) taxiing kids to/from activities for which MOM arranged. (+ MUCH more)
THIS is what my daughters have to look forward to in their lives?
It's not bad enough that my daughter must ENDURE the curse of THE CURSE?
I want my girls to grow up to be STRONG WOMEN. I want them to know that they can handle ANYTHING that life throws their way. Unfortunately, that monthly visit from Aunt Flo is the one thing that many women, strong or not, simply CANNOT escape. Every month, women are PLAGUED with debilitating cramps, bloating, demon-channeling capabilities and LEAKAGE.
Included in my nightly prayers (and, yes, The Viv fuckin' PRAYS) are the makers of Midol and 800mg Motrin. They, at least, can get me through the bloats and cramps and the feeling that my uterus is gonna tear through m'taint and hit the floor.
Am I to believe that we can build Great Walls and pyramids, put men (why, of course) on the moon, store 5,000 songs on a device no bigger that a pinky, sew without thread, live with artificial hearts, balloon boobs to a realistic trip-G, grow new hair, brace for perfect, pearly teeth and block sweat from staining our pits — but we can't seem to figure out a better way to stanch the red flood than to shove a wad of cotton up the HOOHAW?
IF men could menstruate,
we'd've had a curse-cure
How do they keep hemophiliacs from leaking to death?
Why can't we just use THAT?
Or, how 'bout a giant styptic pencil?
IF men were just a wee bit quicker on the uptake, they'd realize that the quicker they cure the curse, the quicker they get 12 extra BONUS weeks to hound us for sex.
Now that I've purchased a few 'bralets' and some of that amazing anti-perspirant for my blossoming nine-year-old babe, my next purchases, no doubt, will be Pre-Teen Midol and a box of maxi pads (with WINGS! of course).
How I cringe at the memory of my middle school maxi pad days.
Ladies, is there anything more disgusting than having to run the mile in PE with a freakin' saturated king-sized pillow between your legs?
True, pads have come a long way in terms of size and absorbancy since the early 80s, thank Gawd, but I feel so sorry for the young girls who have to wear them. Poor things. But, then again, what choice do they really have? TAMPONS? For elementary schoolers? Ugh.
I hopped online in search of SOMETHING — ANYTHING — better than pads and tampons for my babygirl — must she REALLY ride the cotton pony all her life?
As it turns out, the pad and the tampon really ARE the best out there.
I just can't imagine trying to instruct my child in the proper folding technique, let alone the INSERTION and REMOVAL, of the DIVA CUP, and I would rather have her swallow a box of DAMP RID than tell her that she should shove a goddam SEA SPONGE up her little 'tookie'.
The DIVA CUP
The Jam Sponge
"You simply squash it into your vagina and it soaks up the blood."
(A shoe-in for the The Cannes Lions International Advertising Festival.)
No Way in HELL.
So, for now,
until Sir Dyson's
hits Wal-Mart shelves,
pads it is.
I tore apart my basement looking for THE BIBLE of Pre-Pubescent Girls — Are You There God? It's Me, Margaret.
Since the kid's got booblets, I suppose it's time for her to read it. It got me through that God-awful stage. It sure as hell made me happy that the 'Teeange Softies' I had to wear didn't require a belt, though. At least my Kotex had tape strips to adhere to my Days of the Week undergutchies.
Another thing I appreciated about Blume's book was the fact that the main character's mother didn't really make a major ordeal and alert the presses when her daughter gets her period. She sniffles a bit, and says, "My God! You've really got it. My little girl!" And then she goes to get the 'equipment' in the other room. No big whoop.
My own mother wept with pride at my first flow. She couldn't stop hugging me and kissing me and telling me how proud of me she was (as if I had anything to do with it). And then at the dinner table that night, she beamed and proudly announced, "Daddy, our baby girl got her period today! She's not a little girl anymore! Now she's becoming a young WOMAN!" I thought my younger brother was gonna puke. My dad, God bless'im, without really making eye contact, mumbled something like, "Did ya, honey? Well, say now… how 'bout that? Do ya feel all grown up now?" (No, Dad, not really. Actually, I feel like total CRAP. And now, lucky me, I get to feel like this once a month? Me? I feel like a buck-fi'ty. Yippee.)
I know a woman whose family has a Menstruation Tradition, for crissake. When one of their girls gets stricken, one of the other women of the family — NOT the mother, though — presents the child with a fuckin' TIARA to celebrate her induction into the Sisterhood of Stained Pants. Evidently, it's this big family secret, and no one else is allowed to see your tiara. When the girl gets her period every month, and she is feeling like a heifer in heat, she is to go to her room, place the tiara atop her head, and look in the mirror and admire the beauty, the regality of being a woman. I guess the crown is supposed to make her feel better about the monthly sloughing of the lining of her uterus and cellular debris and the fact that she secretly wants to take a crucifix to her vagina a la Regan to take her mind off the pain.
I can say with the fiercest conviction that there willl be no Catamenia Crown for my kid.
There will be no celebration, no 'Welcome to Womanhood' festivities, no 'embrace-and-honor-your-sacred-feminine' speech — no way, no how.
A FUNERAL to mourn my baby's lost childhood, maybe. But menses, my friends, is no cause for celebration. (unless you've been worried about that one-night stand for the last three weeks, that is)
No; no majestic tiara for my little girl.
I'd rather say
'Welcome to 40 Frickin' Years of Abject Agony'
with a heating pad,
a Motrin I.V.,
a Symphony bar
and a 2-lb. bag o' chips.
That's more helpful that a friggin' tiara, I guarantee it.

subset: commoncrawl


text:
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Horizon Bancorp, Inc. is an independent, commercial bank holding company serving Indiana and Michigan through its commercial banking subsidiary, Horizon Bank. Horizon Bancorp, Inc. may be reached online at www.horizonbank.com. Its common stock is traded on the NASDAQ Global Select Market under the symbol HBNC.
Michigan City, Indiana – Horizon Bank has been recognized by the U.S. Small Business Administration's Michigan District Office as a top 10 SBA lender for the state in fiscal year 2016. The honor is given as an indicator of Horizon Bank's overall support, knowledge, and use, of the SBA loan guaranty programs.
Scott Ellison, SBA/Government Loan Program Manager at Horizon, notes that the bank is a Preferred Lender with the SBA, a designation awarded based on his team's knowledge, long-term relationship with the SBA, and ongoing commitment to the SBA Loan Programs. The designation allows the bank to approve and close SBA loans without SBA review – which in turn gives the bank the ability to respond quickly to small business needs.
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Usher On Justin Bieber's Racist Joke ... Pleads the 5th
Usher Pleads the 5th On Bieber's Racist Joke
Usher had the opportunity to join the growing list of BFOJBs who have leaped to Justin Bieber's defense ... but instead he bolted.
Our photog spotted Ush yesterday in L.A. ... and of course asked about the video of 15-year-old Justin using the n-word as the punchline to a horribly unfunny joke.
You'd think, Usher -- being Bieber's longtime mentor and African-American -- would have something to say on the topic, but watch ... who knew he did a Houdini impression?
As we've reported, Floyd Mayweather, Soulja Boy and others have already spoken up for Justin -- which makes Usher's reaction very interesting.
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The configuration of CPU shares is managed by the name service as a property of the project database.
When the first task (or process) that is associated with a project is created through the setproject(3PROJECT) library function, the number of CPU shares defined as resource control project.cpu-shares in the project database is passed to the kernel. A project that does not have the project.cpu-shares resource control defined is assigned one share.
In the following example, this entry in the /etc/project file sets the number of shares for project x-files to 5:
If you alter the number of CPU shares allocated to a project in the database when processes are already running, the number of shares for that project will not be modified at that point. The project must be restarted for the change to become effective.
If you want to temporarily change the number of shares assigned to a project without altering the project's attributes in the project database, use the prctl command. For example, to change the value of project x-files's project.cpu-shares resource control to 3 while processes associated with that project are running, type the following:
# prctl -r -n project.cpu-shares -v 3 -i project x-files
See the prctl(1) man page for more information.
Replaces the current value for the named resource control.
Specifies the name of the resource control.
Specifies the value for the resource control.
Specifies the ID type of the next argument.
Specifies the object of the change. In this instance, project x-files is the object.
Project system with project ID 0 includes all system daemons that are started by the boot-time initialization scripts. system can be viewed as a project with an unlimited number of shares. This means that system is always scheduled first, regardless of how many shares have been given to other projects. If you do not want the system project to have unlimited shares, you can specify a number of shares for this project in the project database.
As stated previously, processes that belong to projects with zero shares are always given zero system priority. Projects with one or more shares are running with priorities one and higher. Thus, projects with zero shares are only scheduled when CPU resources are available that are not requested by a nonzero share project.
The maximum number of shares that can be assigned to one project is 65535.


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Originally, I wanted to post a big rant today about a sponsor whom I collaborated for a giveaway. I actually wrote the blog post and wanted to publish it, but after much consideration, decided to give another week. One more week and if I still do not receive the items as promised, then the blog post which I had written would definitely be published next week.
For today, I'm sharing a video I found on YouTube on different ways to wear scarves! Not all the ideas are great, but some are quite useful if you're wondering how to liven up your wardrobe. I don't wear scarves myself because it's not so feasible with our kind of oppressive weather but I can consider wearing a small one around the neck to jazz up a plain tee perhaps.
Anyway, scarves are definitely in fashion and you can check up this article stay silky smooth with a scarf this fall on more ideas to wear it as a belt or as a bag!


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FIT (the Fédération Internationale des Traducteurs/International Federation of Translators) is an international grouping of associations of translators, interpreters and terminologists. More than 100 professional associations are affiliated, representing over 80 000 translators in 55 countries. The goal of the Federation is to promote professionalism in the disciplines it represents.
The anniversary celebrations will culminate at FIT's 20th World Congress in Berlin in August 4-6, 2014.
Every three years, FIT invites the industry to an international congress. Following successful events in Shanghai in 2008 and San Francisco in 2011, Germany's Federal Association of Interpreters and Translators (BDÜ – Bundesverband der Dolmetscher und Übersetzer e. V.) is delighted to be hosting the professional world in Berlin as the organiser of the XXth FIT World Congress, scheduled for 4th August 2014.
Around the theme
Man vs. Machine?
The Future of Translators, Interpreters and Terminologists
talks, panel discussions and workshops – as well as a trade fair, networking platform and jobs exchange – will bring together agents, agencies, university teachers, software tool providers, students and professional translators, interpreters and terminologists from across the world.
We are happy to announce that EU Commissioner Mrs. Androulla Vassiliou becomes patron of the World Congress.
Gardenia C. Hung, M.A., B.A.
Communications, Languages & Culture Inc.
Consulting Social Media Arts Communications


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Great advice. All too often buyers don't leverage the opportunity to review and make changes to the standard vendor contracts before the final vendor selection is made. I look forward to more of Mr. O'Tooles' HITlaw posts in the future.
HITlaw 11/16/12
Exit Shmexit
When healthcare provider entities merge, whether physician practices or hospitals, there is usually a misalignment of technology. It is not typical that the merging entities operate the same vendor systems, which means that ultimately one vendor is out and the other gains a new (merged) customer.
Here is a real-world example recently brought to my attention. Physician Practice A merges with (larger) Physician Practice B, which basically means Practice B bought out Practice A. The two practices use different EMR products and Practice B dictates that its current EMR technology will remain the standard. Practice A will have to transfer its operations to the other vendor's EMR technology. Not surprising and not a big deal, many are thinking as they read this, because practices convert to different systems all the time.
However, the vendor being replaced at Practice A is not playing nicely and refuses to provide the EMR data in a format that satisfies the technical requirements for conversion. Setting aside the fact that Practice A will have serious record retention issues, they will be unable to access historical patient records (unless they continue to pay for support or subscription to keep the old system, a very unnecessary cost) and will have to start from scratch in the new system. Really?
One would think that bad PR would be enough to persuade the ousted vendor to provide the practice data ready for conversion, but we have seen enough strange stories about sore losers recently to unfortunately have to consider this possibility and behavior.
About the title of this posting – Exit Shmexit? Every software contract should have a section devoted to data rights and extraction at termination. Frequently labeled in conversation as "Exit Procedure" or "Exit Strategy," this type of language is absolutely essential. I take the tone I do because it is clear that unfortunately many practices, and to a lesser extent, some hospitals, do not take the time to carefully review and negotiate the terms and conditions under which they are investing in technology.
Evident in my HITlaw postings is the emphasis on the critical need to review and negotiate your software agreements. "Exit Shmexit" is my personal rebuke to those that consider vendor license agreements as merely "paperwork" and hurriedly review and sign what is put in front of them. Inclusion of a few sentences in Practice A's EMR license would have prevented the present angst and difficulty for that entity.
Although not as pertinent to hospitals due to the size and expense of the technology investment (and corresponding recognition and cooperation by vendors), I am made increasingly aware of instances where physician practices are courted, quoted, and commanded. The first two everyone knows. Commanded refers to the attitude of some vendors at the contract stage. Sign here. We don't negotiate.
Editorial comments now aside, here is the help.
To repeat, every software contract should have a section devoted to data rights and extraction at termination.
Critical inclusions that should be in the software license:
- As between vendor and customer, all data entered into the software database is the property of the customer. This is my nod to the notion that medical records are truly the property of the patient, but that is a topic for another day. The point here is that the customer owns all the data, not the vendor, and the vendor must recognize this.
- Transition must be accommodated. Upon termination of the software contract for whatever reason, all data must be immediately made available to the customer. This is to be provided without question in industry standard format and at no additional cost. This is part of the price of doing business and I have no problem advising my healthcare technology company clients that this must be done.
- The vendor must also agree to provide the data, for an additional cost if necessary, in whatever format is required by the replacement vendor, with a reasonableness factor included regarding technical feasibility.
Dust off your existing EMR license agreement or review the proposed agreements in front of you for that new EMR, PACS system, or HIS as the case may be. No exit procedure? For existing relationships, think about this before you sign with the new vendor. Go back to the existing vendor and address the issue. Far better to do so when there is still a working relationship than after you have told the vendor they will be replaced. For prospective business relationships, get agreement from the vendor as described above (as well as many other important considerations).
Going back to my editorial comments, any customer presented with a contract and the statement that "we do not negotiate" should politely show the salesperson the door. There will be another one from another vendor ready and willing to discuss your needs and listen to your contractual concerns.
This is not to say that vendors must negotiate all terms and conditions as requested by the customer prospect. Vendors are completely within their right to protect their business and intellectual property, limit their liability, and keep sacred the things most important to them. However, to place a contract in front of a prospect with the message "take it or leave it" is not good for business. Unless of course the agreement is written so fairly that it considers not only the company's interests but also the interests of its customers in equal measures. That would be very rare.
Repeated many times in my HITlaw postings is the advice that contract review, at least for major terms and conditions, is a critical part of the vendor selection process. Do not select a vendor and then look at the contract. When you have the search down to a select few vendors, review the contracts in front of you. Look for the smoldering sections that need attention. Recognize the absence of sections of vital importance for your protection during and after the business relationship.
In the example above, the absence of a "data rights at termination" section should be immediately brought to the vendor's attention. If the vendor provides language suitable for your protection, keep them in the game. If they refuse where others cooperate, take them off the list.
Please see my quick tips for an EMR Contract, as well as my paper Selection and Negotiation of EMR Contracts for Providers. Hopefully my general insight and advice will help avoid problem situations such as the one involving unfortunate Practice A.
Previous HITlaw postings were fairly infrequent and arose only when I found a seriously weighty topic. Look forward to more frequent postings on important issues in shorter format. E-mail me with questions and suggestions for future HITlaw writings, whether provider side or vendor side.
William O'Toole is the founder of O'Toole Law Group of Duxbury, MA. You may contact him at firstname.lastname@example.com and follow him on Twitter @OTooleLawHIT.


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Welcome to the Carrollwood Area Business Association!
CABA was formed in 1986 as a networking organization to support the businesses in the growing Carrollwood area. Today, 30 years later, there are over 400 Members representing a large variety of businesses throughout the Greater Carrollwood Area. With many Member benefits including weekly networking, an annual golf tournament and the annual Taste of Carrollwood, is it easy to see why CABA is the "Best Business Address in Tampa Bay!"


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The Butterfly Club Reaches $130,000 Target; Final Gala Countdown Set for Feb 8
The Butterfly Club announced on Friday 11 January that it had achieved its $130,000 target to relocate from South Melbourne to the city centre. The bulk of the money raised has come from two arts foundations as well as a critical $23,700 raised from hundreds of fans following a six week crowd-funding campaign which closed at noon today.
The Butterfly Club's (Mr) Simone Pulga said "The success of this campaign means Melbourne will now get a brand-spanking new 80-seat theatre in the heart of the city, plus 'activate' another little known laneway (Carson Place), adding to Melbourne's vibrant laneway culture".
The Ron and Margaret Dobell Foundation said "We established our foundation primarily to support emerging artists through education and training and the development of performance opportunities. The Butterfly Club has a reputation for being the career starting point for so many of our top performers and is a practical example of putting these aims into practice through its generous support of young and emerging artists."
"We are delighted to put the name of the Ron and Margaret Dobell Foundation to supporting the club in order to preserve this iconic venue which is such an important part of the Melbourne and Australian cabaret scene."
Representing The Campbell Foundation, Trustee Gavin Wright said "The cabaret scene is significantly under-represented in arts funding programs so we're proud to help fill this critical gap by supporting an arts institution that has for so long nurtured and encouraged the cabaret art form."
The crowd-funding campaign saw thousands of fans spread the word and hundreds more buying a diverse range of exclusive experiences and kitsch items donated by the cabaret community. The campaign was designed by Crowded, a new boutique agency specialising in crowd-funding and aligned campaigns. http://crowded.net.au/
What now?
The Butterfly Club remains operating from 5pm nightly (except Mondays) at 204 Bank Street, South Melbourne, so the next four weeks represent a final opportunity for Melburnians to experience its unique charm at that location, described by The Age as 'Melbourne's most intimate nightspot'.
The Butterfly Club will present a series of events to highlight its relocation:
1. A Final Countdown Gala on Friday 8 February
2. A series of invited guests at the current venue; check http://thebutterflyclub.com for full line-up. The final show is Sammy J & Randy's Eviction Party on Sunday 10 February
3. The Cocoon Cabaret season, featuring international acts, in the new venue opening Saturday 16 February
Final Countdown Gala
Join Melbourne's cabaret glitterati as they celebrate the biggest metamorphosis of The Butterfly Club in its 13-year history. The line-up includes Yon (from Tripod), Fiona Scott Norman, Anne Edmonds, Amelia Ryan, Geraldine Quinn, Gillian Cosgriff, Karin Muiznieks, Sarah Gaul and Trevor Jones.
Location: Melbourne Town Hall Friday 8 Feb at 8pm Tickets: $45 Bookings: http://thebutterflyclub.com
The Gala will be followed by an after-party (sold out) at The Butterfly Club, 204 Bank Street.
Sammy J & Randy's Eviction Party
Before they conquered Melbourne, Edinburgh, and Montreal, they started out right here at The Butterfly Club. Now they've been given the honour of being the final ever show in the South Melbourne premises. No pressure.
Location: 204 Bank Street, South Melbourne Sun 10 Feb at 9:30pm - tickets $28 to $35 Bookings: http://thebutterflyclub.com
Cocoon Cabaret
It hosts Australia's largest collection of kitsch, is celebrated for its cocktails and quirkiness, launches more new shows than any other venue in Australia, and is renowned as a Melbourne icon around the world. So you'd expect it would take The Butterfly Club a few weeks to get everything juuuust right before its metamorphosis is complete.
Join us for the Cocoon Cabaret season marking our metamorphosis as the new home of The Butterfly Club. Cocoon Cabaret features international guests from Saturday 16 February through to the start of the Melbourne International Comedy Festival on Wednesday 27 March. Guest acts include: Spanky (UK) who will launch both the venue and a national tour on Sat 16 Feb Joanna Weinberg (South Africa), 16 & 17 Feb Trixie Little and the Evil Hate Monkey (New York), 25 Feb to 3 March David Raleigh (New York), 25 Feb to 3 March Mindy Button (UK), 18 to 24 March
Location: 256 Collins Street, enter Carson Place (rear laneway off Little Collins St) Saturday 16 February through to Wednesday 27 March, various times - check website for full details Bookings: http://thebutterflyclub.com


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Beat the Streak Report: Wednesday, August 31
Ladies and gentlemen, your NEW undisputed, uncontested undefeated and untied BTS season leader … Mr. Steve Summer.
Ichiro came through yet again for our main man last night, advancing Steve to 42 games with a single in five at-bats against Jerome Williams and the Angels.
Only 14 other players have reached 42 games in nearly 11 seasons of BTS play, and one more correct selection would vault Steve into a tie for eighth place all-time in this here Streaking game.
Of course, no Streaker has ever reached the mythical land of 56 games — a mark Steve could challenge as early as Sept. 13. That is, if the stars align, the tea leaves are favorable and Ichiro keeps on hitting.
Wednesday's picks:
(Make a BTS pick)
Oh, hello there…
Melky Cabrera: .545 (6-for-11) since '06 vs. Tigers starter Rick Porcello
Pablo Sandoval: .400 (6-for-15) since '06 vs. Cubs starter Rodrigo Lopez
Starlin Castro: .444 (4-for-9) since '06 vs. Giants starter Madison Bumgarner
Joey Votto: .444 (4-for-9) since '06 vs. Phillies starter Cliff Lee
Andre Ethier: .385 (5-for-13) since '06 vs. Padres starter Wade LeBlanc
Feeling kinda spicy?
Miguel Cairo: .571 (8-for-14) since '06 vs. Phillies starter Cliff Lee
Matt Diaz: .533 (8-for-15) since '06 vs. Astros starter J.A. Happ
Casey Blake: .417 (5-for-12) since '06 vs. Padres starter Wade LeBlanc
You'll thank me later
Mark Teixeira: .182 (8-for-44) since '06 vs. Red Sox starter Josh Beckett
Erick Aybar: .175 (7-for-40) since '06 vs. Mariners starter Felix Hernandez
Matt Holliday: .200 (5-for-25) since '06 vs. Brewers starter Randy Wolf
Matt Kemp: .100 (1-for-10) since '06 vs. Padres starter Wade LeBlanc
Jose Tabata: .100 (1-for-10) since '06 vs. Astros starter J.A. Happ
Top MLB Streakers
David Ortiz: 13 games
Brandon Phillips: 13 games
Mike Moustakas: 13 games
J.J. Hardy: 13 games
Ichiro Suzuki: 13 games
Home Run Beat the Streak pick:
David Wright: (11 home runs this season) vs. Marlins starter Chris Volstad
23 Comments
W25 no pick
W22 143 points.
81 points at half. Should hit 143
143+ ? If so, could start putting some pressure on w25.
Yes. Don't know how much ime is left but it's at 141 at the moment. So it'll hit the over.
145. Over is good.
Now w23.
I just noticed that I am now the LEADER in the active bloggers group!!!
And, of course, I have a narrow 1-game lead and had no clue who to pick today, so I went with the normally reliable Ichiro against Dan Haren.
Upon looking at Ichiro a bit closer, I noticed that his strikeouts are way down recently, which had previously been the sign that he was slumping.
So here's hoping that he's just getting ready to break out!
Does the SFTC carry over to next month? If not, why are people with lower streaks even playing? Why not wait?
Still up in the air. There's one guy with active w25 and one at w23 both with a chance to get 27.
Ok, I'll be keeping an eye on them.
W23 going with Ukraine to lose by upto 14.
W25 still no pick.
Where do you guys go to follow European basketball?
I'm just using flashscore.com
Heres the link.
Russia up 4 @ half. 28-24 sounds like a really bad game
An that's the ball game. Russia wins but only by 9.
Now we have a w24 & w25. Should be an interesting finish to the night.
Leader has some luck on his side: Cubs just 2 hits in 7 innings & Castro has one
Interesting there as the only other hitter I was considering for tonight besides Ichiro was Marlon Byrd, who got the only other hit for the Cubs today.
I was just scared off because Byrd has struggled so badly against the Cubs this year.
Correction: has struggled so badly against lefties* this year.
Leader and co-leader in SFTC at 26 and 25 respectively with Beckett's strikeout. One more for the leader and prize money is reset tomorrow. Unless the co-leader is able to win it.
Adam Lind gets me to 5 and I'm in position for my 1st save since the 21st (exactly 10 days ago) with Craig Kimbrel. The Braves are up 3-1 after 7 so I am looking for a tie in the 8th inning or either team to outscore the other by 1 at the most. I'm trying to break a 9 day futility in the FR BTS game.
2 outs bottom 8th 3-1 Braves
I'm finally back on board on Fast Relief BTS.


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There was not an exact match for the language you toggled to. You have been redirected to the nearest matching page within this section.
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Food and Drink in MalaysiaKirsty Turner
Hawker stalls and coffee shops are good places to find a cheap and tasty meal. Hawker stalls tend to be very clean and open until late in the evening. Curry dishes and other meals in western style restaurants, while seafood restaurants serve fresh fish prepared in the Chinese style. For western food, head to the shopping malls, where you will usually find a large food court with a number of well known fast food restaurants.
Here is a selection of the numerous dishes you will find on your travels in Malaysia:
Nasi lemak – the most common Malaysian breakfast dish consists rice cooked in light coconut milk with anchovies, peanuts, a slice of cucumber and a little chilli.
Rendang – usually made with beef, this dry curry dish consists of stewed meat in a spicy curry paste.
Chilli crab – a whole crab is covered with a generous amount of sticky, strong chilli sauce.
Laksa – this dish varies from place to place but is basically a coconut both with seafood or chicken.
Bak chor mee – this noodle dish is cooked in a chilli-based sauce with minced pork, fried anchovies, vegetables and mushrooms.
Popiah - these delicious spring rolls can be either fried or raw. Filled with boiled turnips, fried tofu, fried shallots and garlic, chopped omelette, chopped stir fried long beans, there is usually a sweet chilli sauce to dip them in.
Hainanese chicken rice - usually found on street stalls, this steamed chicken dish is served with special gently spiced rice and tasty ginger.
Bubur cha-cha – a traditional Malay desert with cubed yam, sweet potato and sago added to coconut milk soup.
Kuih – this sweet desert is made with coconut milk, coconut flesh and either glutinous rice or tapioca. It is often made into cute and colourful designs.
Avoid drinking tap water and drinks with ice in Malaysia. Bottled water is cheap and easy to find.
Coffee – known as kopi – and tea – teh – are both popular and tasty drinks in Malaysia as well as a local variation known as teh tarik. Tea and coffee usually comes hot, with condensed milk to sweeten it. If you don't want milk ask for teh o, while teh ais will get you iced milky tea.
Also popular is a drink known as kopi tongkat ali ginseng, which is a mixture of coffee, a local aphrodisiacal root and ginseng served with condensed milk.
Despite being a predominately Muslim country, alcohol is widely available throughout Malaysia. Beer and other alcohol can be bought in bars, restaurants and 7-11 shops. The local brew is tuak, which fermented rice wine that comes in many forms. Usually served lukewarm, tuak is often flavoured with sugar or honey.


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Rugby cauldron starts bubbling
Huw Turner
June 13, 2011
Tournament organiser Martin Snedden has declared the 2011 World Cup will be one New Zealanders are proud of © Getty Images
Rugby World Cup 2011 is just around the corner - the tournaments opening fixture between the All Blacks and Tonga at Auckland's Eden Park just three months away. In many parts of New Zealand the sense of anticipation is now tangible, the state of physical preparedness visible as the finishing touches are put to the various pieces of infrastructure which will either transport or accommodate visitors to this exquisitely beautiful country.
While the Christchurch earthquakes reduced the city to rubble and took out of play one of the World Cup's major playing centres, RWC organisers have gone quietly about their business of absorbing and compensating for the non-participation of one of the world's greatest rugby playing regions.
Arrivals at Auckland's International Airport will be greeted by upgrades in the terminal and in the brand new accommodation available outside; upgrades to the roads in Auckland city and on the fringes of the city are intended to ease the traffic flow in a seriously congested city; the finishing touches are being applied to a number of stadia around the country. At least 60,000 international visitors are expected to come to New Zealand, 2,000 of them media personnel, and the Auckland region alone is expected to benefit from an injection of NZ$315m (£157m) to the local economy. At a time of economic hardship, and times are very hard indeed, this is not a negligible amount
On the various TV channels and in the newspapers, the multinationals and Australasian big businesses are beginning to make their presence felt. All Blacks from the present and recent past seem to be queueing up to endorse every type of product from motor vehicles to deodorants; a commercial bonanza which is only just beginning to unfold and gain momentum.
However, this World Cup will be about much more than the commercial spin-offs, and so it should be. The IRB was much criticised in awarding the tournament to New Zealand, clearly the world's leading rugby playing nation but an isolated couple of islands in the South Pacific with a population of less than four million people. The commercial opportunities would have been much greater in taking the tournament to somewhere like Japan, where the game is struggling to establish itself but which might have benefitted from the exposure a World Cup would have given it.
I suspect that visitors to New Zealand this coming September/October will experience a culture where the rugby is immersed in the history and development of the country in a way it would be impossible to witness anywhere else, with the possible exception of Wales. Away from the corporate centres, the relative glitz and the glamour, the high stakes associated with a professionalised global sport, visitors will be able to glimpse and savour everyday New Zealanders clinging onto what they call 'grassroots' rugby and in the process celebrate their local culture and how rugby still contributes to that.
Whangarei is a small city about two and a half hours north of Auckland, situated on the Pacific North East coast and will be the World Cup's most northerly staging post. The drive north takes the traveller through rolling farmland and glorious coastal scenery. Whangarei will host two World Cup pool games, Canada v Tonga and Tonga v Japan; in rugby playing terms nothing to get too excited about. Except that in this sprawling, sparsely populated semi sub-tropical region, rugby has really struggled to survive the introduction of professional rugby and anything that can be done to generate interest is welcomed.
While North Auckland, as it was in the days before professionalism, and now Northland, has always produced top rugby talent they have also always struggled to resist the playing and living opportunities in the larger metropolitan areas. Legendary All Black scrum-half Sid Going (who will never forget his duels with the equally legendary Gareth Edwards on the British and Irish Lions' 1971 tour?) can still be seen prowling the touchlines of Northland in the winter months barking orders to his beloved Mid Northern club side.
About 40 minutes south of Whangarei there are a number of coastal farming settlements around Bream Bay, named by Captain James Cook when he passed this way at the end of the eighteenth century. At the southern end of Bream Bay is a beautiful but curious little township called Waipu where Canadian visitors to the World Cup can expect a big welcome in September.
The first European settlers landed here in the early 1850's, a strange, cult-like band led by the aged and severe Rev. Norman McLeod. They had left Scotland for Nova Scotia in search of religious freedom and a better life but many of them found the climate too harsh in Canada. But they stayed 30 years before heading to Australia and then on to Auckland and then Waipu. Their story is told in a beautifully refurbished museum and the links to Nova Scotia remain strong, with a number of community events in recent years hosting visitors from Canada. Waipu is also the home of a famous and long-running Highland Games, held every new year and attracting competitors from all around the world.
In advance of Canada's September 14 match against Tonga, the Waipu community is planning a welcome for Canadian, and indeed all visiting, rugby supporters. It is hoped the Canadian side, or at least some members of it, will be in attendance and it is intended to be a great communal celebration with the Waipu Rugby Club available as the watering hole and the rugby grounds available for camping and camper vans.
The Highland Pipe Band will lead the Highland Dancing and there will be a photographic exhibition - 'Men in Kilts' - recording the community's kilted rugby links with a club in Southland. Then there will be transport provided to the Canada v Tonga game, if anyone is sober enough to get on the coach.
I cannot imagine any of this happening if the tournament had been awarded to Japan!
© ESPN Sports Media Ltd.
|Live Scores
'Concussion is not worth the risk'
Concussion, relegation and the mother of all surprises - it's the Monday Maul.
Jones key to Wales World Cup plans
Huw Richards assesses where Wales are after a mixed Six Nations, with front row seats still very much available for the World Cup
Attacking revolution will be fleeting
John Mitchell lapped up the action on 'Sensational Saturday' - but warns not to expect a repeat come Rugby World Cup time later this year
Ireland, England are dangers if ...
Craig Dowd warns England, Ireland and Wales they should play to their strengths rather than those of the All Blacks and the Wallabies


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Brewers lose to Cardinals Saturday
Team playing with heavy hearts
Adam Wainwright pitched seven strong innings and the St. Louis Cardinals sent Milwaukee to its seventh straight loss, 10-2 on Saturday as the Brewers mourned the death of shortstop Jean Segura's young son.
Segura left the team and traveled home to the Dominican Republic, a day after his 9-month-old son died. The Brewers observed a moment of silence for Janniel Segura, and the clubhouse was closed before the game.
The 24-year-old shortstop was put on the bereavement list when he learned after the Brewers' 7-6 loss to St. Louis on Friday night that his son had died. Manager Ron Roenicke said the boy had been ill.
Tony Cruz drove in a career-high three runs and Kolten Wong homered as the Cardinals pulled into a first-place tie with Milwaukee in the NL Central. St. Louis trailed by 6 1/2 games on July 1.
The Brewers have lost 11 of 12. They had held sole possession of first place since April 9.
Frustrated Brewers star Carlos Gomez struck out swinging in the fifth inning and tried three times without success to break the bat over his leg. He slammed his helmet and tore up his batting gloves.
Wainwright (12-4) helped himself with an RBI single and tied Cincinnati's Alfredo Simon and the Yankees' Masahiro Tanaka for the most wins in the majors.
Wainwright gave up two runs and five hits. He has allowed just four earned runs in his last six starts.
Jimmy Nelson (1-1) went 4 1/3 innings, giving up eight runs and eight hits. He was recalled from Triple-A Nashville on Thursday to make his first start since replacing ineffective Marco Estrada in the rotation.
St. Louis took a 3-0 lead in the first inning. A two-out error by second baseman Scooter Gennett on a grounder set up Cruz's two-run single.
Wong hit a two-run homer in the second. It was his fifth home run in the last six games since coming back from the disabled list.
Cruz doubled home a run in the third.
NOTES: Milwaukee recalled INF Elian Herrera from Triple-A Nashville to replace Segura on the roster. ... The Brewers will start RHP Wily Peralta (9-6) in the series finale Sunday against Carlos Martinez (2-3).


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7 of 10
Easy Vanilla Pudding
Smooth, creamy, and way better than the store-bought stuff.
We don't call this recipe easy for nothing. This simple, delicious pudding comes together with just a handful of ingredients and a little stirring. You mix sugar, cornstarch, and a bit of salt, then whisk in milk and egg yolks.... Read More
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New display highlights Flour Mill Museum
By Colleen Burns
The Flour Mill Museum is currently closed, but you can still learn about its history and artifacts in a new display at the Mackenzie Library.
The installation, located in the public stairwell at the Main Branch of the Sudbury Public Library features photos and information about artifacts from the Flour Mill Museum's collection, providing a peek into what daily life was like for local households at the turn of the last century. The display also outlines the history of the area, and shares details about the current project to move the museum to a new location.
The Flour Mill Museum is closed for the time being, as Museums staff prepare it for its upcoming relocation, which will allow for alterations to the water/wastewater lift station that shares its current location.
When asked what prompted the idea for the new display, Museums staff Sarah Small explains, "I wanted to provide some insight into the (move) project and let people know what work is involved. A lot of museums work is behind-the-scenes and this display gives people a little view into that world."
"There is a lot of paperwork, photography, research and packing associated with every artifact," Laura Koskocky, curatorial assistant with City of Greater Sudbury Museums, adds. "The museum staff are working very diligently to complete these tasks and have provided exceptional work thus far."
This project has uncovered some fascinating artifacts, many of which have been in storage for several years.
"Many of the Flour Mill Museum's collection of artifacts are within storage, as there is no room to display them all at once," Koskocky says. "We aim to use some of these unique and interesting artifacts within new exhibitions once the Flour Mill Museum has relocated."
Samantha Morel, the Museums' Curator explains that, "It's important for museum artifacts to be rotated in and out of storage to prevent too much continuous permanent damage from light and other environment factors to which they are subject during display. The rotation of artifacts means the whole collection can be preserved longer for the benefit of future generations.
"Luckily, unlike many larger museums, the Flour Mill Museum is able to display a greater total proportion of its artifacts at any one time (about 30 per cent) due to the size and nature of its collection."
Here are two examples of interesting artifacts within the museum's collection:
Sick Call Kit
This type of item was very common in Franco-Sudburian homes in the early 1900s. It was decorated with Catholic imagery and contained a number of sacramental objects, each blessed by a priest. In those days, people often spent their final days in the home, surrounded by family. The Sick Call kit ensured that household members would receive their Last Rites at home. The Sick Call Kit is just one example from the collection of the deep importance of the Catholic faith to the neighbourhood's francophone residents at the turn of 20th century.
Hot Water Bottle
Homes at the turn of the century were poorly insulated, and most often heated with a wood- or coal-fired stove located in the kitchen and/or living room. To make cold nighttimes comfortable, heavy ceramic bottles would be filled with hot water and placed under the covers to warm up the beds.
The public is invited to play "Guess the Artifact" in an interactive part of the display, featuring other rare and unique items that highlight the history of the Flour Mill area.
Members of the public are invited to visit the Greater Sudbury Museums' other three locations this summer. More information about the Greater Sudbury Museums, their hours of operation and free programs can be found at www.facebook.com/sudburymuseums or on Instagram @GreaterSudburyMuseums.
— Colleen Burns is with Greater Sudbury Museums.


text: Looking for that perfect pair of new Work Boots? Check out our great deals on Steel Toe Boots, Logger Boots or Wellington Boots at the Sportsman's Guide. Keep your feet protected when you're on or off the job with a variety of low, mid and hi-top styles. Browse through our Men's Work Boots and find the perfect pair for you.


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With Valentine's Day quickly approaching, it's time to start planning your special day! Whether you're looking to have a romantic dinner for two, enjoy an intimate weekend getaway or dance the night away, Temecula Wine Country has something for everyone. Check out all of the Valentine's Day events our member wineries have planned especially for you and yours!
California Dreamin' Hot Air Balloon Rides – Special Valentine Balloon Ride and Bottle
Sunday and Monday, February 13 and 14
Float in a cloud of romance as the sun rises over wine country and then enjoy mimosas back on the ground at Vindemia Winery. In honor of Valentine's Day, every couple will be presented with a bottle of 2005 Vindemia Syrah as a memento to remember their visit. $158 per person; Reservations required 1-800-373-3359
Callaway Vineyard & Winery- Vino d' Amore Valentine's Dinner
Saturday, February 12, 2011; 6:00pm-9:00pm
$90.00 per person; Legacy Club Members price $81.00 per person (Prices are per person, plus tax)
Romance is in the air at Callaway! To celebrate couples in love and the occasion of Valentine's Day, the annual Vino d' Amore Valentine's Dinner will be held in our romantic, candlelit Barrel Room where intimate tables for two await you and your loved one. Enjoy a sparkling wine reception with passed hors d'oeuvres, live entertainment and a scrumptious served dinner perfectly paired with award-winning Callaway wine. Check out the menu and purchase your tickets here!
Callaway Vineyard & Winery- Valentine's Long Weekend at Meritage Restaurant
Friday, February 11 through Monday, February 14
Lunch hours: 11am-4pm daily
Dinner Hours: 5:00pm-9:00pm Friday and Saturday evening
$35.00 per person, plus service charge and sales tax. Not valid with coupons or any other offer; Reservations not accepted for groups under 8.
Meritage is the perfect spot for Valentines! With it's heated, terraced patio overlooking rolling hills of vineyards and snow-capped mountains, it makes the perfect dining spot for couples. Join us for lunch or dinner Valentine's weekend for a special Valentine's prix-fixe dinner. Check out the menu and call (951) 587-8889 for more information.
Falkner Winery- Pinnacle Restaurant Valentine's Wine Dinners
February 12th-14th
$79/person plus tax and gratuity; $69/person for Wine Club Members
The Pinnacle Restaurant at Falkner Winery will host romantic evenings with Valentine's Wine Dinners in their award winning restaurant in Temecula. The dinners will be wonderful four course meals with individual wine pairings of the Falkner's best wines in this panoramic, hill-top location. All dinner seatings will offer the same great food, sparkling wines, entertainment, and first class service. All food will be prepared under the direction of Executive Chef Gianni Ciciliot who was recently voted "Best Chef" by readers of Inland Empire magazine for the second year in a row. Seatings for these wonderful and memorable events will be at 7pm on Sunday the 13th and Monday the 14th and 5:30pm and 8:30pm on Saturday the 12th. The dinners on Saturday at 8:30pm and 7pm on Sunday and Monday will be preceded by a 30 minute Champagne Reception for those that arrive early.
Check out the menu and to make reservations, call 951-676-8231 x1 or or make them online under the Restaurant Reservation tab.
Falkner Winery- Pinnacle Restaurant Valentine's Wine Lunch Special
February 11th-14th
Come enjoy the Valentine's Lunch Special in the Pinnacle Restaurant. For $55 plus tax and gratuity for two people, diners will be able to have either one shared appetizer or salad for two; a choice of individual entrees such as Sweet Soy Glazed Seared Ahi served over Ginger Sautéed Spinach and Baby Carrots or Chicken Penne Pasta served with Artichoke Hearts, Fresh Tomatoes, Garlic, Shallots, Sun-Dried Tomatoes, and a White Grilled Chicken Sauce; and dessert of a shared Cheesecake or Molten Chocolate Cake. Also included will be a non-alcoholic beverage per person. Selected wines will be offered as an option with the Special at $5/glass. This special will be available in addition to the normal menu so make reservations soon. Diners will enjoy the wonderful and romantic Valentine hilltop ambiance of the Pinnacle. Call the winery at 951-676-8231 ext 1 for reservations or make them online under the Restaurant Reservation tab.
Keyways Vineyards and Winery – Cupid's Walk, A Romantic Winery Tour
Monday, February 14; 3-4pm
An affordable activity for lovers. Includes wine tasting, chocolate fondue, souvenir glass, & live music. Purchase your tickets here. Reservations required (951) 302-7888.
Keyways Vineyard & Winery- That's Amore!
Saturday February 12th, 2011; 6:30 – 9:30pm
4 Course Romantic Valentines Dinner and World Class Live Entertainment
Members: $89 plus Tax & Gratuity
Non-Members: $99 plus Tax & Gratuity
21+ Only Please. Purchase tickets here.
Lorimar Winery- Valentine's Party
February 12th; 6pm – 9pm
Amore, The Day of Love, Saint Valentines Day… This day is traditionally a day on which lovers express their love for each other by presenting flowers, offering confectionery and sending greeting cards… here at Lorimar Winery, we would like to toast our love to you by offering a complimentary glass of Sparkling wine! Light Appetizers and classic tunes and love songs will be performed by Kenny Marquez.
Lorimar Winery- Wine & Art Series
Entire month of February
Heather Van Gaale, a versatile photographer based in Southern California, is bringing a taste of her work to Old Town Temecula. Heather splits her time between Temecula, where she does commissioned portraits of children, families, women & weddings, and Los Angeles, where she rubs shoulders with celebrities and captures the latest fashions on film and is the photographer at a production company, Rock & Rodeo. Her work will be featured at Lorimar Winery's Old Town Tasting Room during the month of February with a special "Meet the Artist" reception on February 19th at 6pm. Call 951.240.5177.
Miramonte Winery- Valentine: An Intimate Affair
February 14, 2011; 6:30pm
$95 for wine club, $115 for non-club. Elevated cocktail attire, please.
After a three year hiatus, our most popular event ever—Valentine—is back. Shimmering candlelight. Four courses of elegant cuisine. Alluring wines. Live classical guitar. The evening is hosted by Cane Vanderhoof, and each course is presented by Chef Volker. We invite you to join us for an unforgettable Valentine celebration!
Seating is limited. For reservations, please call (951) 506-5500 #105.
Mount Palomar Winery- Valentine's Day Dinner for Two
Saturday – February 12, 2011 & Sunday – February 13, 2011
Make this Valentine's Day one to remember, by spending it with someone special at Mount Palomar Winery. At our Dinner for Two event you will be impressed with our romantic and unique venue. You will be served a four course meal and a glass of your favorite wine that is sure to please the pallet and leave you with a very memorable experience.
Reservations will be scheduled from 12:30 – 8:30 pm
$75 per couple ($60 for Wine Club Members)
– Includes a four course meal for two and a glass of wine per person.
RSVP TODAY- online, by calling 951-676-5047 x112 or email email@example.com. Pre-payment and pre-ordering is required to attend the event.
When you RSVP, please have both guests select from the menu.
Oak Mountain Winery- Valentine's Day Winemaker Dinner
Saturday, February 12, 2011; 6:00pm – 9:00pm
$75.00 Wine Club Member, $85.00 Non Member (plus tax & 20% gratuity)
Join Chef Michael Cragg and Oak Mountain's Winemaker Steve Andrews and his wife Valerie for a special Winemaker Dinner. Chef Michael from the Ritz Carlton, is pulling out all the stops for this Filet Mignon dinner paired with Oak Mountain wines. Check out the menu and reserve today! Reservations required (non refundable 3 days prior to event). For tickets, call 951 699-9102 or email email@example.com.
Be sure to check back for Part 2 of the special events and we look forward to seeing you this Valentine's Day in Temecula Wine Country.


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Mobile telecom
TRA completes key mobile network survey
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Asiacell launches offer of 25pc share capital
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Smartphones, tablets see record adoption
Smartphones and tablets are being adopted at a rate 10 times faster than PCs from the 1980s, two times faster than the Internet in the 1990s, and three times faster than the current social networking boom, said a report by analytics firm Flurry.More…


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Are you Hank Marvin?
We have a signed Fender Squier electric guitar to give away to one of our readers, and are also offering the chance for you to see your work published by CR, in return for a poster of your dream gig…
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We have a signed Fender Squier electric guitar to give away to one of our readers, and are also offering the chance for you to see your work published by CR, in return for a poster of your dream gig…
Ben & Jerry's global social mission officer Dave Rapaport talks to Anna Burzlaff, head of cultural insights and strategy agency Truth, about the brand's approach to activism, and what it takes to make credible change in the world today
Hospitality has been hit hard by the pandemic, but in the midst of increased restrictions restaurateurs are finding creative ways to reach hungry punters at home. Here, we delve into how restaurant brands are adapting to the new normal
With commissions from the New York Times and Medium, Xinmei Liu enjoys combining nostalgia with satire to create surreal and surprising illustrations
The Tony's Chocolonely brand started as a way to change the cocoa industry. Here, we get an insight into its visual branding and what being a responsible chocolate brand means
Modern Love illustrator Brian Rea recounts a childhood filled with stories, shares the struggles of embracing his style and tells CR why words have gained a new importance for him later in his career
Ben Cullen has built up a cult following for his mesmerising illusion cakes, which have appeared everywhere from Slowthai's recent music video to Jurgen Klopp's birthday party. He talks about how his career journey took him from graphic design to tattooing to cake artistry
TfL's hallowed roundel has been transformed into the iconic PlayStation symbols, as part of a stunt to celebrate the launch of Sony's latest console
The photographer's portraits of teenagers, taken after the cancellation of milestone events such as proms and graduations, emphasise the impact of 2020's summer lockdown
A new illustrated book of classic fairytales uses technology to illuminate gender bias by reversing the gender of the characters and narratives
The author explores the rise of cancel culture in new documentary Offended by Irvine Welsh, where he discusses the threat that the phenomenon poses to the creative industries and why he thinks Trainspotting wouldn't be published today
The artist and long-time Radiohead collaborator has left his "depressing flyposters" behind in favour of new artworks designed to spread joy in ten cities across the UK
Following the release of her explosive phone-hack series I Hate Suzie, Lucy Prebble talks about her belief that every story benefits from a little drama, and how an ongoing infatuation with tech inspired her to write for video games
Julius Pringles and Colonel Sanders have both been subjected to a shave to celebrate the month-long Movember challenge
As a new exhibition at the Photographers' Gallery in London brings together over four decades of his work, we speak to photographer Sunil Gupta about how his work straddles the world of activism, documentary and art
Ghanaian visual artist Prince Gyasi creates striking, vivid imagery photographed with an iPhone. CR talks to him about his unconventional practice and how it helps local children get an education
Hiro Murai's dream-like vision has produced unforgettable imagery for artists including Childish Gambino and FKA twigs. Here, the filmmaker discusses the joys of collaboration, exploring the realm of television with the series Atlanta, and why This is America is an anomaly in music videos
With new Sony and Microsoft ad campaigns out, CR explores whether game advertising has lost its edge, and what the future holds for console makers operating in a more complicated market than ever before
The cult Instagram account celebrating real-life Anderson-esque moments has been reimagined in book form – complete with a foreword written by the director himself
Satirical puppet show Spitting Image is back after a 24-year hiatus, and features everyone from President Trump's tweeting anus to a James Corden-Cats hybrid. Here, we speak to the creatives behind the programme's unique brand of public service satire
Continuing our series on creative partnerships, RBI global CMO Fernando Machado and Pancho Cassis, global CCO at agency David, reveal how 5am WhatsApp chats, lawyers and healthy arguments go into Burger King's award-winning work
Cardiff-based illustrator and graphic designer Matt Needle has spent the last seven months putting his own spin on all 25 of the original posters from the cult James Bond film franchise
Originally published in 1983, Graham's first photography book A1: The Great North Road is being republished by Mack. Here he reflects on the project nearly 40 years later


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The chart totals over 100% because respondents were allowed multiple choices. That's too bad because it skews things a bit. Yes, the iPad is stomping everyone, but 94.5% has less meaning when the total comes to nearly 150%.
It's better to look at this one column at a time, where we can determine a device's absolute rejection (not acceptance). For example, we don't know that 3.8% of respondents would buy a RIM PlayBook, because it may have been their second choice, but we do know 96.2% of respondents rejected it outright, since it's not on their list at all.
I think of the beatdown like this: for each iPad competitor (column), 90% or more of respondents rejected it. In other words, nine out of 10 people wouldn't even put it on their list as a second choice. Meanwhile, the iPad is rejected only 5.5% of the time. Put it all together and we know not only that the vast majority of respondents are interested in the iPad, but that for most of them there is no Plan B.


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It is that beautiful time of year. Kids are going back to school. The leaves are changing.
You might not be thinking about it now but we are planning for another big rush of holiday card holder orders. To get ready we have redesigned the website and started launching a series of videos.
Please take a moment to browse the new website design at http://www.holidaycardholders.com and let us know what you think.


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Bayes offers cleaning products that are used for home, patio, vehicle, and floor cleaning. Our products are non-abrasive and non-toxic, and are never tested on animals. None of our products contain animal ingredients, and several of them have been approved by the EPA.
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Our everyday cleaning choices affect our health, the health of our families, and the health of our planet. Biokleen products are concentrated in order to leave the smallest footprint on the environment.
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GO by greenshield organic®, a division of Greenology Products, Inc. was created by a dad on a mission to protect families from the harmful chemicals found in most cleaning products. Under our GO by greenshield organic® brand, we manufacture the leading line of USDA Certified Organic Laundry Detergents, Spray, and Specialty Cleaners in the country. We offer healthy cleaning products that perform, are available at competitive prices and are made in the USA!
Greenberry Premium quality disinfecting wipes and cleaning products kill germs and deodorize all in one . In most cases they contain natural plant based ingredients such as Lemongrass and Aloe and chamomile , and are safe for all household cleaning needs.
Grove Collaborative is dedicated to helping you create a healthy, beautiful home. Through our Grove Co brand, we design our products with love and the best natural ingredients to elevate your everyday. From personal care to home cleaning, we make products with an unwavering commitment to efficacy, thoughtful design and the health of your family and planet.
Hain Celestial is a leading personal care products company, with well-known brands such as Jason, Zia Natural Skincare, Avalon Organics, Alba Botanica and Queen Helene.
Create a globally recognized solution that provides science-backed products and innovative consumer engagement technologies to empower women, men, and children to fully-embrace the well-being of life.
Live for Tomorrow is a range of environmentally friendly household cleaning products.
LuckyPlanet is our line of house hold cleaners. This is a plant-based line of products such as ,All Purpose Cleaner, Toilet Cleaner, Laundry Detergent Unscented, Dishwashing Liquid Soap and Glass Cleaner. These products will be develoed of naturally-derived products that are made from renewable resources and which have a minimum impact on our world. We'll be launching more items in the future.
MamaSuds helps ingredient savvy women who want to create a safe, non-toxic home by using environmentally conscious products.
Powerizer Complete is a revolutionary USDA Certified Biobased Product standing in a category of its own. The detergent's percent of Biobased content exceeds the minimum USDA Certified requirements in 4 categories of the USDA BioPreferred Program, laundry, dishes, multipurpose cleaners, carpet and upholstery. It's septic safe, high-efficient, created using plant and mineral-based ingredients and contains a color safe bleach. The sunny citrus fragrance is synthetic and meant to rinse clean so that oil residue won't be left behind. Powerizer eliminates the possibilities of skin allergies, spots on dishes or residues settling in your machines. It's scoop measures less than two tablespoons of a dry granular powder. One scoop or less will tackle laundry, dishes, carpet, appliances and everyday household cleaning. It's also a machine cleaner helping to keep both machines functioning at optimal performance. Powerizer is sold in a 1.0, 3.0 lb. & a 6.5 lb. pouch at www.powerizerclean.com
Puracy specializes in Natural Cleaners, Plant-Based Soaps, and Organic Lotions. Developed by Doctors, Trusted by Families. 100% USA Made and Cruelty-Free.
Pure & Gentle Soaps are specially formulated for pure, soft-conditioned water. Chemical agents such as phosphates, dyes and nitrates, are removed from our products and are replaced with extra performance ingredients. PGI products consistently out perform leading national branded products.
PGI Soap Company is committed to the environment by formulating 100% biodegradable, dye and phosphate free products. No animal testing is performed on any PGI product.
Home is our safe space where we grow and nurture our family. It needs to be kept clean for a healthy living environment, and Pure Sense is the perfect solution for that. Formulated with environmentally conscious ingredients, we make sure to keep your home and its surface finishes clean and polished. All fragrances are derived from natural essential oils; no synthetic fragrances.
We at Sound Earth are strong believers in "the ripple effect": what we do as individuals effects those around us, and those around them. This is why we donate 10% of all profits to various local, national, and international not–for–profit organizations.
Sunny & Honey was created by loving animal owners to help improve the lives of their own little family members with only the highest quality products available. Our products became very popular with friends and family, which launched our new mission – to help as many animals throughout the world as possible. Our products are manufactured in United States, and we give back 10% of our profits to all types of pet related causes.
In 1995, The Good Home Co. began with a dream and $5000 in my home kitchen. I hoped to create a line of products using natural ingredients whenever possible and that smelled of wonderful memories inspired by summers spent with my grandparents on their farm.
Hi! We're Joe and Lauren, founders of ThreeMain. As tech entrepreneurs turned eco-advocates, we're on a mission to tackle two problems affecting our families, friends and the planet – plastic & toxins. Our Cleaners help reduce the growing plastic crisis while using REAL ingredients that attack bacteria and viruses and leave no mess behind.
While we're busy eliminating plastic in the household cleaning space, we know that is not enough. There is an incredible amount of plastic pollution that exists already, but we believe the damage can be undone. That's why we've partnered with Rozalia Project, donating 3% of all sales to protect and clean the ocean using technology, innovation, solutions-based research and engaging STEM programs.
ZolaTerra is passionate about healthy cleaning! Get ready for a revolutionary line of cleaners you have always wanted! Healthy cleaning made simple with No gloves and No mask required! A safe, yet highly effective, line of plant based cleaners, degreasers, spot removers and deodorizers. Safe for parents, kids, pets and the environment! ZolaTerra's line of products are UNLIKE any other products sold today.
All ZolaTerra products are family made in the USA! Cleaning products powered by the sun and safe for the earth!