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Shields turns in solid outing, but Royals drop finale
KC's bid for series sweep spoiled as march back to .500 continues
KANSAS CITY -- No sweep. Nothing that sweet.
Kansas City had to settle for winning the series after the Detroit Tigers snagged the finale, 4-1, on Sunday with 20,513 fans at Kauffman Stadium. The Royals had won the first two games of their first series following the All-Star break.
The loss put the Royals seven games behind the first-place Tigers in the American League Central and left them five games under .500 at 45-50.
"Going into the second half, we've got a number of goals," Royals manager Ned Yost said. "One is to get back to .500. But two is to win series. If we'd have won today and swept 'em, that would've been fantastic. But the consolation prize is we won the series and our mindset from here on it is we've got to continue to focus on winning series. ... If we can do that from here to the end of the year, we're going to be in pretty good shape."
Now 16 games into what's considered a crucial 20-game stretch against five top teams, the Royals stand 7-9 with Baltimore arriving on Monday for a four-game series.
"Just a good win for us, to come back after losing the first two tough games," Tigers manager Jim Leyland said. "They played a heck of a series. Their defense really stuck out this entire series."
The Royals got a quality outing from James Shields, who struck out six while allowing three earned in seven innings.
The Tigers' Miguel Cabrera, who went into the All-Star break with 30 home runs, hit No. 31 in the first inning -- a lined shot down the left-field line off Shields.
Yost noted that Shields' pitch was five inches inside and he was surprised that Cabrera kept the ball fair.
"When I went back and looked at it, it was inside right above the chalk in the batter's box," Shields said. "That's why he's probably the best hitter as far as I'm concerned. He did a pretty good job right there and put a good swing on it."
The Royals' Miguel Tejada, who went into the All-Star break with two home runs, hit No. 3 to left field in the second inning off Doug Fister to form a 1-1 tie.
This was the first time that Tejada had ever faced Fister, and he caught hold of an 0-1 fastball. His homer was the only extra-base hit off Fister, who gave up five other hits and one walk.
It was a case of Tejada displaying the other side of his game. In the top of that inning, he roamed to the shortstop side of his second base position to snag a deflected ground ball and managed to wing a throw to first baseman Eric Hosmer, nicking Jhonny Peralta. At the time, Victor Martinez was on second base with a leadoff double.
"As soon as I saw the ball hit Shields' glove, I went after it. One thing I had in mind was to see if the runner [Martinez] was going to try to go to third. In that situation, I didn't want for the ball to get past the infield," Tejada said.
Andy Dirks moved the Tigers ahead, 2-1, in the fifth inning with the game's third home run.
"When it was hit, I didn't think it would make the warning track. That surprised me that it carried that far," Yost said.
Center fielder Jarrod Dyson had backed into the wall to take Cabrera's distant drive in the fourth inning but he couldn't snag Dirks' smash. The ball passed just past the leaping Dyson's glove and fell behind the wall 410 feet away.
"I was pretty close, but I couldn't get my glove on it. Probably a couple inches from my glove," Dyson said. "I wish I'd have caught that though."
In fact, Leyland thought he did catch it.
"I said, 'You've got to be kidding me.' And then all of a sudden, I saw Dirks keep running. I thought Dyson had the ball originally," Leyland said.
"They probably have as good of an outfield defensively as you'll see in the big leagues today. With [Lorenzo] Cain and Dyson and [Alex] Gordon, that's as good of a defensive outfield as you're going to see. You ain't going to see any better."
In the seventh, the Tigers loaded the bases with no outs against Shields on singles by Prince Fielder, Martinez and Peralta. The latter was a sharp shot off Shields' left thigh, which he chased down but couldn't pick up near first base. Shields stayed in the game and finished the inning.
"It hurts. Right on the inner thigh," Shields said. "It's not really known as a contact sport. A couple starts ago I got hit pretty hard and it hit one of my arteries or something and it exploded, but you've got to tough it out and move on."
Shields struck out Dirks, but ex-Royals catcher Brayan Pena sent a sacrifice fly into center field for a 3-1 lead. Ramon Santiago singled to left, again loading the bases, but Shields struck out Austin Jackson with his 99th and last pitch of the 82-degree afternoon.
The Tigers added a ninth-inning run against Kelvin Herrera on Peralta's double, Dirks' single and Pena's second sacrifice fly.
After Fister's six innings, three Tigers relievers held the Royals to just one hit in the last three innings. There would be no sweep.
"You're always mad when you have the chance to sweep some guys and miss the opportunity to do it. That's a good club over there and we battled and took two from them so we won the series," Dyson said. "Unfortunately we didn't win the sweep, that's what we wanted. We're trying to creep back into this thing."
There are 67 games left in which to do that creeping.
"We won two out of three against the first-place team in our division," Shields said. "I'll take that all day and move on."


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100% GOTS certified organic cotton tee
Crew neck tee with Nature in Balance women print designed exclusively by artist TY Williams in collaboration with Maurie + Eve
Pictured here on the beautiful Elle Ferguson
This classic piece runs large. We recommend you purchase down a size.
What is GOTS certified organic cotton?
Globally recognised certified 100% organic cotton fibre which can be traced back to the farmer and throughout the supply chain. GOTS cotton is grown in an organic agricultural environment free from genetically modified seeds and harmful chemicals and pesticides
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subset: commoncrawl


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Premiere Sunday Up Over Last Year
60 MINUTES Wins Timeslot with Year-to-Year Audience Growth
AMAZING RACE Delivers Increases Over Last Season's Premiere
CBS Premiere Sunday scored gains on a night of heavy competition, increasing its audience from last year +7% in viewers (11.72m from 10.93m), + 22% in adlts 18-49 (3.3/09 from 2.7/07) and +14% in adults 25-54 (4.0/10 from 3.5/08). 60 MINUTES scored its best premiere delivery in years, with significant growth from last season's opener, while THE AMAZING RACE showed increases over last year, according to Nielsen preliminary Live Plus Same Day ratings for Sunday, Sept. 27.
[Editor's note: the prime time averages include 15 minutes of NFL over-run into the 7:00 PM hour and all ratings are subject to change when updated numbers come in Tuesday]
60 MINUTES at 7:00 PM was first in households (10.3/18), viewers (16.23m), adults 25-54 (5.1/14) and adults 18-49 (4.1/13). Compared to last year's season premiere, 60 MINTUES was up +29% in households (from 8.0/14), +76% in adults 25-54 (from 2.9/08), +86% in adults 18-49 (from 2.2/07) and added +3.64m viewers (from 12.59m, +29%). This is 60 MINUTES best premiere delivery in households and adults 25-54 since 2005 and in viewers and adults 18-49 since 1999.
Compared to last year's one-hour season premiere, THE AMAZING RACE was up +7% in households (6.5/10, from 6.1/09), +3% in adults 25-54 (4.1/10 from 4.0/09) and +6% in adults 18-49 (3.4/08 from 3.2/08).
For the night, CBS was second in households (7.3/12), viewers (11.72m), tied for second in adults 25-54 (4.0/10, with ABC) and delivered a 3.3/09 in adults 18-49.
Updated ratings will be available Tuesday morning.


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Faced with the worst Ebola outbreak in history, West African governments have struggled to find an effective response. More than 1,550 people have died from the hemorrhagic fever since it was first detected in the forests of Guinea in March.
Residents of the impoverished seaside district of West Point in Monrovia were forcibly cut off from the rest of the capital in mid-August after a crowd attacked an Ebola center there, allowing the sick to flee.
The quarantine sparked protests and security forces responded with tear gas and bullets, killing a teenaged boy.
But at dawn on Saturday, the community woke up to find the soldiers and barricades gone.
"I tell God thank you. I tell everyone thank you," said Koffa, a female resident of West Point. Others danced in the streets chanting slogans like "we are free" while others rolled about on the asphalt pavement in celebration.
President Ellen Johnson-Sirleaf, a U.S.-educated Nobel Peace Prize winner, has sought to quell criticism of the government's response by issuing orders threatening officials with dismissal for failing to report for work or for fleeing the country, and has ordered an investigation into the West Point shooting.
Liberia, where infection rates are highest, plans to build five new Ebola treatment centers each with capacity for 100 beds, government and health officials said on Saturday.
In neighboring Sierra Leone, President Ernest Bai Koromo dismissed his health minister Miatta Kargbo on Friday over her handling of the epidemic which has killed more than 400 people there.
Her replacement Abubakarr Fofana on Saturday confirmed that a third doctor in the county had died from Ebola, further hampering its ability to respond to the outbreak.
"It is with a deep sense of sadness that we have lost one of our finest physicians in the line of duty at a time like when we need a lot of them to help in out fight against Ebola," he said.
Physician Dr. Sahr Rogers caught the disease while treating outpatients in the same hospital where a doctor died last month and where British nurse William Pooley was also infected.
Transmitted through the vomit, blood and sweat of the sick, Ebola has also spread to Nigeria and Senegal, which reported its first confirmed case on Friday - a Guinean student who was lost to authorities in his own country while under surveillance.
"His brother came from Sierra Leone where he was infected and has died. Shortly afterwards, this student left for Senegal," said Dr. Rafi Diallo, spokesman for the Guinean health ministry.
Two other members of his family - his sister and mother - have died from Ebola, Guinean health ministry sources said.
A resident in the suburb of the Senegalese capital Dakar where the student resided said on Saturday that a team of health ministry officials wearing white protective suits and masks came to spray disinfectant at his home and a local grocer's shop.
Many Dakar residents worry that the student could have spread the highly contagious virus in the three weeks since he was last reported in Guinea.
In Nigeria, where an infected traveler collapsed after arriving the Lagos airport, there have so far been 19 suspected, probable and confirmed cases and seven deaths.
"To avoid a situation like Nigeria, they need to be able to follow hundreds of contacts," said epidemiologist Jorge Castilla of the European Commission's Humanitarian Aid and Civil Protection Department in Dakar. "Whatever they do, there will probably be a second set of sick people as this guy has been here for some time."
Senegal has since closed its land border with Guinea and halted flights to Guinea, Sierra Leone and Liberia, defying advice from the World Health Organization (WHO) that there is no need for travel restrictions.
A note from the WHO and the International Civil Aviation Organization sent to health ministries on Aug. 29 said: "Lives are being unnecessarily lost because health care workers cannot travel to the affected countries, and delivery of life saving equipment and supplies is being delayed."
The World Food Programme said it needs to raise $70 million to feed 1.3 million people at risk from shortages in the Ebola-quarantined areas in West Africa, with the agency's resources already stretched by several major humanitarian crises.


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Venezuela tense ahead of dueling demonstrations
CARACAS, Venezuela (AP) -- A crowd of anti-government activists wrested free an opposition politician as he was being hauled away in handcuffs by security forces following a raid on the party headquarters of President Nicolas Maduro's biggest foe.
Dario Ramirez, a city councilman, shouted "I'm an elected official" as national guardsmen, surrounded by journalists and party activists, frantically looked for an escape route from the Caracas shopping mall where they took him into custody. Once outside, dozens of activists banging pots and pans in protest attacked the squad, freeing Ramirez by force and speeding him away on a motorcycle.
The dramatic scene underscored the rising tensions that could spill over into violence Tuesday when pro- and anti-government activists hold dueling demonstrations in the capital.
Ramirez belongs to the Popular Will party led by Leopoldo Lopez, the target of a police manhunt accused by Maduro of inciting violence and leading a U.S.-backed conspiracy to oust him from power.
Maduro's government on Monday gave three U.S. Embassy officials 48 hours to leave the country, charging that the Obama administration is siding with opposition protesters.
Foreign Minister Elias Jaua said the senior U.S. consular officers were trying to infiltrate Venezuelan universities, the hotbed of the recent unrest, under the cover of doing visa outreach.
The U.S. denied the charges, and is expressing concern about rising violence and the government's attempts to block peaceful protests.
Secretary of State John Kerry said Saturday that Lopez's arrest would have a "chilling effect" on Venezuelans' right to free expression.
More than 1,000 students, who have spent the past week on the streets alternating between peaceful protests by day and battles with police at night, marched on Monday to Venezuela's telecommunications regulator to demand it lift all restrictions on the news media's coverage of the unfolding political crisis.
Police repelled the activists with tear gas and rubber bullets but there were no reports of serious injuries.
Several journalists have been harassed and detained in the past week. Colombia's news channel NTN24 was taken off cable television while covering protests Wednesday that ended in a battle between student demonstrators and security forces backed by armed pro-government militias.
Three people were killed during those clashes last week -- two students and a pro-government demonstrator. News videos and photographs taken at the time indicate at least one of the students was killed when pro-government militia members fired directly at protesters.
Maduro accuses Lopez of being behind the violence and of leading a "fascist" plot to overthrow him two months after his party's candidates won mayoral elections by a landslide. At a rally with thousands of supporters Saturday, Maduro dared Lopez, a Harvard-educated former mayor, to turn himself in after a court ordered his arrest on charges ranging from homicide to vandalism of public property.
Lopez said he doesn't fear going to jail to defend his beliefs. In a video message Sunday, he called on supporters to march with him in white shirts Tuesday to the Interior Ministry, where he'll deliver a petition demanding the government protect citizens' rights to peacefully protest.
"I haven't committed any crime," said Lopez, who hasn't been seen in public since a Wednesday night news conference after the bloodshed. "If there is a decision to legally throw me in jail I'll submit myself to this persecution."
To avoid another violent clash, Lopez aides rerouted their Tuesday protest away from the central plaza in Caracas where a competing march of pro-government oil workers will take place.
Maduro called for the Tuesday march by supporters in a televised address Sunday in which he accused the U.S. of trying to stir up unrest to regain dominance of South America's largest oil producer.
As evidence to support those claims, Jaua on Monday presented what he said was a series of emails from embassy officials from 2009-11 soliciting funding from Washington to support student groups in Venezuela. He said more recent communications also exist, but are under wraps during an investigation.
The three expelled officials -- Breeann Marie McCusker, Jeffrey Gordon Elsen and Kristofer Lee Clark -- all enjoyed the rank of second secretary, and two of them were vice consuls, Jaua said.
In Washington, the State Department said it hadn't received any formal notification of the expulsions. It said reports that the U.S. is helping organize protests are "baseless and false" and called on the Venezuelan government to engage the opposition in "meaningful dialogue."
Associated Press writers Fabiola Sanchez and Andrew Rosati contributed to this report.


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Recently, Neila Deen, our director of sales and business development, was asked to talk about her "next hottest nabe" for the NY Daily News' "Ask A Broker" column. This question made for a great article, and also sparked some intense discussion around the office. While everyone has their personal favorite up and coming area, we managed to stop arguing about the price per square foot in Brooklyn versus the Upper East Side long enough to put together a list of New York City's next hottest neighborhoods.
Bushwick (Brooklyn) – While most of downtown Brooklyn has already seen new development and price jumps, a good value can still be had in Bushwick. Williamsburg became hot because is was a short ride on the L to the East Village, and the same logic applies to Bushwick's close proximity to Williamsburg, which has become the new epicenter of cool. With it's close proximity to Williamsburg and easy subway connections for commuters, Bushwick is well on its way to being the next big thing.
Yorkville (Manhattan) – While first time buyers have been deserting Manhattan in favor of Brooklyn, and with prices skyrocketing in areas like Williamsburg and Dumbo, Yorkville is poised for a comeback for those who want an easy commute and great housing stock. With some of the lowest prices per square foot in Manhattan below 96th Street, and the Second Avenue Subway under construction, now is the time to buy.
Grand Concourse (Bronx) – Recently designated landmark status, a grand history, Yankee Stadium and a huge concentration of Art Deco architecture make the Grand Concourse area of the Bronx a neighborhood ready for a resurgence. Prices are very low and could see a significant increase as the city implements redevelopment plans including a waterfront park, lofts, shops, hotel and recreation. And where else can you get a renovated classic 7 with open views for $300K? With excellent transit options already in place, the Grand Concourse has major "hot nabe" potential.
Red Hook (Brooklyn) – Ikea and Fairway Market have already set up shop here. There's prime, waterfront property available for luxury development. The biggest stumbling block at this point is the Culver Viaduct Rehabilitation project, which has the subway to Red Hook shut down until 2012. Red Hook's potential is contingent upon this project wrapping up in a timely fashion and subway service being restored to the area.
Clinton Hill (Brooklyn) – Another favorite neighborhood for families, Clinton Hill is seeing a rapid upswing in retail and residential development as well as renovation on many of the brownstone lined streets. Neighborhood schools have active parent participation, and the area is still relatively quiet and family friendly. With close proximity to trendy amenities in Downtown Brooklyn and Fort Greene, Clinton Hill is well on its way.
Greenpoint (Brooklyn) – Formerly an industrial area, Greenpoint was rezoned by the city in 2005 to provide for conversion to residential and retail. Home to McCarren Park, extensive luxury developments, and proximity to other, well-established areas of Brooklyn (namely, Williamsburg), make Greenpoint an attractive buy.
LIC (Queens) – Long Island City boasts a tremendous amount of prime waterfront, luxury development, studio space and art galleries. Restaurants and retail continue to flood the area and the streets are filled with stroller pushing families. Commuting to midtown Manhattan is a breeze, making LIC a no-brainer.
Sunnyside (Queens) – Nestled between LIC, Astoria, and Woodside, Sunnyside is only a 15 minute subway ride to midtown, but has a very strong residential feel. For those that want quiet residential streets, but to still have close proximities to the funky areas of Long Island City, Greenpoint and Williamsburg, Sunnyside is ideal. And with prices in Long Island City on the rise, it only makes sense that Sunnyside is next.
Rockaway Beach (Queens) – Billed as a lower cost, less bourgeois alternative to the Hamptons, Rockaway Beach is a surf town in New York City. Reminiscent of Williamsburg at the beginning of its upswing, Rockaway Beach has a young, hip vibe, with cheap property. Restaurants, food stands and nightclubs continue to open up as demand increases, and word is spreading that Rockaway Beach is a cool destination accessible by the A train.
Flatiron (Manhattan) – The Flatiron neighborhood is the epicenter of New York's white hot Silicon Alley, and with the New York Tech scene now overtaking Boston as the second biggest start-up area, this neighborhood is on the rise. Fueled by venture capital, the companies are hiring at a pace that exceeds the rest of the city, and have attracted great services, restaurants and amenities to an area that used to play second fiddle to it's neighbors Gramercy and Chelsea. As hot as the Flatiron neighborhood has been, it will only get better in 2012.


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Comparative Bioequivalence Study of Wockhardt's Insulin Analogue Mixture Listro Mix 75/25® and Humalog Mix75/25 ® in Healthy Subjects
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01400802
Recruitment Status : Withdrawn (Study was not initiated)
First Posted : July 22, 2011
Last Update Posted : January 25, 2013
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Bioequivalence in Healthy Subjects
|Biological: Insulin Lispro
|Phase 1
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|0 participants
|Intervention Model:
|Crossover Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Health Services Research
|Study Start Date :
|November 2011
|Estimated Primary Completion Date :
|May 2012
|Estimated Study Completion Date :
|June 2012
Experimental: Listro Mix75/25®
Insulin Lispro/ insulin Lispro protamine (Listro Mix75/25®; 100 U/mL), DispoPen 3.0 mL.
Biological: Insulin Lispro
Dosage form- Subcutaneous Injection
Other Name: Listro Mix75/25® ,Humalog Mix75/25®
Active Comparator: Humalog Mix75/25®
Insulin Lispro/ insulin Lispro protamine (Humalog® Mix75/25TM; 100 U/mL), Humalog Mix 75/25® Kwik PenTM 3.0 mL.
Biological: Insulin Lispro
Dosage form- Subcutaneous Injection
Other Name: Listro Mix75/25® ,Humalog Mix75/25®
- Bioequivalence based on Pharmacokinetic parameter: AUC (INS-LIS 0-20h) [ Time Frame: 20 hrs post dose ]Glucose clamp will be terminated 22 hours post dose and the primary pharmacokinetic bioequivalance will be calculated based on the Area under the curve (AUC) between 0 - 20 hours postdose of the study medication.
- Bioequivalence based on Pharmacodynamic parameter: AUC (GIR 0-20h) [ Time Frame: 20 hrs post dose ]Glucose clamp will be terminated 22 hours post dose and the primary pharmacodymanic bioequivalance will be calculated based on the Area under the curve (AUC) for the glucose infusion rate (GIR) between 0 - 20 hours postdose of the study medication
- Pharmacokinetic parameter: Area under curve from 0-22 hrs [ Time Frame: Over 22 hrs post dose ]AUC (INS-LIS 0-6h), AUC (INS-LIS 6-12h), AUC (INS-LIS 0-12h), AUC (INS-LIS 6-20h), AUC (INS-LIS 0-22h), AUC (INS-LIS 0-∞)
- Pharmacodynamic parameters: Area under curve glucose infusion rate from 0-22hrs [ Time Frame: Over 22 hrs post dose ]AUC (GIR 0-6h), AUC (GIR 0-12h), AUC (GIR 6-12h), AUC (GIR 6-20h), AUC (GIR 0-22h)
- Safety endpoints [ Time Frame: Over 22 hrs post dose ]Number of AE's, SAE's, Hypoglycemic events and local tolerability
- Pharmacokinetic parameters:Maximum concentration (Cmax) [ Time Frame: Over 22 hrs postdose ]
- Pharmacokinetic Parameters: tmax and t1/2 [ Time Frame: Over 22 hrs postdose ]
- Pharmacodynamic parameter: GIR max and tGIR max [ Time Frame: Over 22 hrs postdose ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 50 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Healthy male or female subjects.
- Age ≥18 and ≤50 years.
- Considered generally healthy upon completion of medical history, physical examination and biochemical investigations as judged by the Investigator.
- Body Mass Index (BMI) between 18.0 and 27.0 kg/m2, inclusive.
- Non-smoker, defined as no nicotine consumption for at least one year.
- Signed and dated informed consent obtained before any trial-related activities. (Trial-related activities are any procedure that would not have been performed during normal management of the subject.)
Exclusion Criteria:
- Previous participation in this trial or other clinical trials within the last 30 days.
- Pregnant, breast-feeding or the intention of becoming pregnant or not using adequate contraceptive measures (e.g. intrauterine device (IUD) that has been in place for at least 3 months, or sterilization, or the oral contraceptive pill, which should have been taken without difficulty for at least 3 months, or an approved hormonal implant or double barrier method including male condoms used plus spermicide , diaphragm with spermicide plus male condom cap with spermicide plus male condom are acceptable options).
- Clinically significant abnormal hematology or biochemistry screening tests, as judged by the Investigator. In particular, subjects with elevated liver enzymes (AST or ALT >2 times the upper limit of normal) or impaired renal function (elevated serum creatinine values above the upper limit of normal) or elevated blood glucose at screening as measured by YSI (> 5.5 mmol/L / 100 mg/dL) will not be allowed to enter the trial. Subjects with abnormal TSH may be required to have additional testing of thyroid hormones for further clarification. Subjects with abnormal TSH judged by the Investigator as clinically significant will be excluded from the study.
- Any serious systemic infectious disease during the four weeks prior to the first dose of test drug, as judged by the Investigator.
- History of any illness that, in the opinion of the Investigator, might confound the results of the trial or pose risk in administering the trial drug to the subject. In particular, subjects with significant cardiovascular disease, anemia (hemoglobin below the lower limit of normal) or hemoglobinopathy will not be allowed to enter the trial.
- Cardiac problems defined as decompensated heart failure (New York Heart Association (NYHA) class III and IV) at any time and/or angina pectoris within the last 12 months and/or acute myocardial infarction at any time.
- Clinically significant abnormal ECG at screening, as judged by the Investigator.
- History of alcohol or drug abuse in the past five years.
- Any positive screen for drugs of abuse.
- Hepatitis B or C or HIV positive.
- Use of prescription drugs within 3 weeks preceding the first dosing of insulin, except for oral contraceptives/hormonal implants.
- Use of non-prescription drugs, except routine vitamins or herbal products, within 3 weeks prior to the first dose of the test drug.
- Occasional use of acetaminophen is permitted. Acetaminophen is not allowed on the dosing day until 4 hours postdosing.
- Use of systemic corticosteroids, monoamine oxidase (MAO) inhibitors, prostaglandin blockers, systemic non-selective beta-blockers, growth hormones
- Thyroid hormones are not allowed unless stable during the past 3 months.
- Any use of non-steroid anti-inflammatory drugs (NSAIDs) except for low-dose Aspirin is not allowed within 7 days prior to dosing and on the dosing day.
- Mental incapacity, unwillingness or language barriers precluding adequate understanding or co-operation.
- Blood donation of more than 500 ml within the last 12 weeks.
- History of multiple and/or severe allergies to drugs or foods or a history of severe anaphylactic reaction.
- Known or suspected allergy to trial product or related products.
- History of deep leg vein thrombosis or a frequent appearance of deep leg vein thrombosis in 1st degree relatives (parents, siblings or children) as judged by the Investigator.
- Any disease or condition that, in the opinion of the Investigator, would represent an unacceptable risk for the subject's safety.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01400802
|United States, California
|Profil Institute for Clinical Research, Inc.
|San Diego, California, United States, 91911
|Responsible Party:
|Dr.R Jha ,Senior Vice-president - Clinical Research, Wockhardt Limited
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
Listro Mix75/25/PK-PD/FDA/2011
|First Posted:
|July 22, 2011 Key Record Dates
|Last Update Posted:
|January 25, 2013
|Last Verified:
|January 2013
Insulin Lispro
Hypoglycemic Agents
Physiological Effects of Drugs


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6 teens charged in sexting case
Six northeast Iowa teenagers have been charged with misdemeanors stemming from distribution of an obscene photo taken by a fellow student.
The case began with a teen girl taking her own picture with a cellphone and sending it to a teenage boy at Independence Junior/Senior High School in Independence. He forwarded it to several friends, who sent it on to several others.
Buchanan County Attorney Shawn Harden said a student who received the forwarded photo reported it to his parents, who then contacted the school. The school reported it to law enforcement officials.
The six students were arrested last week and soon were released to their parents.
Iowa law bars using a phone to send obscene material to a minor.
Law enforcement officials said sexting is becoming a major problem.
"Basically you're talking about nude or partially nude images of one minor usually to another or to someone else via their cell phone," said Michael Ferjak of the Iowa Department of Justice. "To them it's just 30 seconds of fun, 30 seconds of bad judgment without any consideration for what that leads to or could lead to."
Ferjak is a cyber-crime investigator. He said that what teens don't realize is that sexting according to Iowa law, can be considered spreading child pornography.
"What it has become is a major concern for the criminal justice system," said Ferjak.
Studies show teens feel pressure to engage in sexting. Seventy percent of sexting incidents are part of a boy/girl scenario while 51 percent of girls surveyed say they feel peer pressure from a boyfriend or male friend and 18 percent of males say they also feel pressure.
The pictures often spread like wildfire.
"I think parents, teachers, community members -- everybody -- needs to be talking about this because whether you choose to accept the fact or not it it probably present in your community, and if it is then some of your kids are at risk," said Ferjak.


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Peter Dizikes, MIT News Office
With the recent launch of MIT's Institute for Medical Engineering and Science, MIT News examines research with the potential to reshape medicine and health care through new scientific knowledge, novel treatments and products, better management of medical data, and improvements in health-care delivery.
An online health-insurance exchange is coming to your state. How effective will it be?
That is an increasingly important question in the United States. In June 2012, the Supreme Court upheld the legality of the country's Affordable Care Act, passed by Congress and signed into law by President Barack Obama in 2010. The program mandates private-sector health insurance for all citizens, and provides subsidies for those who otherwise could not afford it. Insurance-plan choices will be available through exchanges, or marketplaces; most people will be able to study plans and sign up for one online. As of December, nearly 20 states have elected to run exchanges themselves; the federal government will run the exchanges in other states.
And therein lies a key issue: Creating a consumer-friendly exchange is no easy task. It is hard enough to know what kinds of foods we should eat, which cars to drive, or which apps to use. Selecting an insurance plan is a far more complex decision.
"Health insurance is a confusing and difficult choice," says Jonathan Gruber, a professor of economics at MIT who specializes in health-care issues. "It's important that people make decisions in an organized and effective market. In that way they can make the best choices, and we can ensure the best level of competition among insurers."
Gruber would know: He provided crucial modeling that helped shape both the statewide health-care plan that former Gov. Mitt Romney signed into law in Massachusetts, in 2006, and the Affordable Care Act. Gruber has also served on the board overseeing the exchange in Massachusetts — the one state, because of the 2006 law, that already has an online portal up and running.
Moreover, as Gruber readily acknowledges, state-run insurance exchanges must pull off a difficult balancing act. The point of markets is to provide competition, but academic research shows that when people are given too many choices, they struggle to select logical options for themselves.
"The tension that exchanges face," Gruber says, "is [having] enough standardization to make choice and competition work effectively, but not so much standardization that people can't find the plans that best fit their tastes. That's absolutely a central tension." To handle this challenge, policymakers and academic researchers will almost certainly have to collaborate in productive ways.
Swamped by insurance choices
Indeed, plenty of research suggests that America's existing health-care offerings are already too complex. In a 2006 survey by the Kaiser Family Foundation and the Harvard School of Public Health, 73 percent of seniors, 91 percent of pharmacists, and 92 percent of doctors felt that Medicare's prescription drug plan — Medicare Part D — was too complicated.
Meanwhile, a wealth of studies in behavioral economics suggest that having too much choice is problematic for consumers; one much-cited experiment from 1995, by Columbia University business professor Sheena Iyengar, shows that consumers are far more likely to buy jam at the supermarket when presented with many fewer product choices. Iyengar and economist Emir Kamenica of the University of Chicago have shown that increasing the number of risky 401(k) plan choices available to people leads them to opt for safer plans.
In the health-insurance domain, Gruber and Jason Abaluck, an economist at Yale University, published a study in the American Economic Review in 2011 showing that a large number of seniors select Medicare Part D plans that are mismatched to their needs. For one thing, seniors place too much emphasis on lower premiums, as opposed to plans that defray more out-of-pocket costs. Optimal choices, the researchers found, would make these health-insurance plans 27 percent more valuable to seniors.
However, seniors were often unable to make apt decisions because, in part, they typically had more than 40 stand-alone drug plans to select from. Overall, Gruber and Abaluck concluded, "Consumers would be better off if there were less scope for choosing the wrong plan."
One solution: Metallic tiers
To combat this problem, the Massachusetts exchange and its online portal, the Health Connector, divide insurance plans into three tiers by cost: gold, silver and bronze. Consumers who know what tier they can afford can then study options at that level before deciding. In this way, the exchange organizes the options and helps winnow the range of choices for consumers to a manageable quantity. The Health Connector also aims to offer clear information about plans — "decision support," as scholars call it — to consumers.
That kind of grouping by price, Gruber notes, means insurers are in theory then "competing on things like [the scope of] their provider network, and efficiency of delivery," judgments consumers are likely to be adept at making. But the means of making exchanges work will almost certainly have to be refined over time.
"That is a key part of the process, and a key research topic," Gruber says. "What's the best way to inform consumer decisions around this?"
That research will likely be conducted in various ways. In Massachusetts, state officials noted publicly that they wanted to attract more small businesses, not just individual consumers, to the state exchange, and have conducted focus groups with small-business owners to find out just what kinds of plan features they want. Academic health-care scholars will likely seek further data sets on consumer behavior.
And since many states will be constructing their own distinct exchanges, the implementation of the Affordable Care Act should be a boon to scholars, as it will provide a variety of cases for study and comparison, leading to valuable "feedback loops," as Gruber puts it, between policy and research.
"I think there's going to be an experimental learning process as we figure out the trade-offs between different numbers of choices, the heterogeneity of choices, and decision support," Gruber concludes.


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It's seems like Bill Gates is still in shape and his sense of humor is the same as 20 years ago. He was Jimmy Fallon's guest last night, promoting his website, GatesLetter.com with the help of this little clip.
Here's the complete segment:
Did they remove Fallon's Macbook during Gates' visit? Don't worry, it was on his desk throughout the whole interview:
Here's the follow-up, where Gates talks about how interacting with computers will change in the future.
Bill Gates' Viral Video: GatesLetter.com [YouTube]
To contact the author of this post, write to: firstname.lastname@example.com
G/O Media may get a commission


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'Damn You Auto Correct' Unveils 11 Funniest Texts of 2012
Damn You Auto Correct Reveals 11 Funniest Texts of 2012
Last year around this time, we cringed and laughed until we cried at the embarrassing collection of auto-correct text messages sent to friends and loved ones throughout the year. You'd think we would have learned our lesson to double check each and every word by now.
Popular blog Damn You Auto Correct — which features a collection of outrageous auto-corrected text messages submitted by readers — has revealed its top picks of 2012, based on Facebook shares, tweets, comments and page views. And believe us, this year's selection does not disappoint.
Damn You Auto Correct Reveals 9 Funniest Texts of the Year
As most smartphone users know, the auto-correct feature on mobile phones is key for catching sneaky typos that would otherwise fall through the cracks. But on some occasions, a word is automatically replaced with one that is entirely wrong in context and it can create a beautiful mess.
Here's a look at the laugh-out-loud texts of the year — let us know your favorites in the comments below.
Warning: Some of the content is NSFW.
Thumbnail via Spiderstock


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I was pretty damn satisfied with my 2006 Classics Megatron. He was gray and black and green and orange and purple and he transformed into a motherfuckin' Nerf gun. The green and orange and purple was really only there to help him pass toy gun regulations, but it really made me love him. Plus, you know, Nerf gun. Bonus.
And so when we were first introduced to the new, bigger Leader Class Megatron, I was initially a little meh. The new toy was in classic colors, meaning the purple and orange and green were gone, and he was back to being silver and black and red. Silver and black and red are fine colors, it's just, y'know, not as interesting to me. Plus the toy fell into the body proportion aesthetic a lot of the new Transformers team's stuff seemed to find itself in -- wide body with thin legs. It's a good set of proportions for Animated Batman, but I prefer my bots to be more stompy.
But, well, Stuff is happening in the comics. Megatron's an Autobot now. He's joined the cast of my favorite Transformers fiction, and it's phenomenal. And this new Leader Class Megatron toy would include a change of Autobot faction stickers to represent that development. Suddenly the toy became Lost Light Megatron, and I had to have it. Sure, the rest of him's not specifically designed after the body he has in the comics now -- it's more of a generic "G1 Megatron as a silver tank" thing -- but it's close enough and that's its official intent and that's how my brain works. Plus he's a big enough toy to actually fit in with my Lost Light display. Slapping an Autobot symbol on my Classics Megatron would result in a guy who stands eye-to-eye with my Rodimus and Brainstorm, and that just won't do.
Original misgivings aside, he's a great toy in person. His skinny legs aren't bothersome when he's actually in front of you in 3D, and they ratchet to and fro with satisfying clicks. Plus his legs are shaped that way to accommodate his real working rubber treads. He's got a set of real working rubber treads on his back and a set in his legs. They don't combine into one single pair of working treads in tank mode, but that's fine.
That the toy is mostly covered in silver paint also helps. He's this giant shiny attractive thing, and there aren't huge spots of unpaintable nylon plastic breaking up his silver like some metallic-painted Transformers have. Sure, there are a handful of unpainted silver spots, but they're not conspicuous or incongruous. Despite not having purple or green, he's an attractive chunk of plastic. He does have some orange detail, though. I'm sure it helps.
In tank mode he's got a rotating turret... if you leave him half-transformed. The proper instructions have you close his pelvis onto the back of the turret, locking it in place, but if you don't connect that piece, he's engineered so that the whole turret rotates. He's got springloaded missile launcher in his barrel/arm cannon, and also both of his secondary tank weapons combine into a longer rifile for him to carry in robot mode. When you lift up his chestplate during transformation, there's a sculpted spark casing under there, with details borrowed from its appearance in Beast Wars.
This toy is also available in Armada Megatron flavor, if you so choose. That version has a new head (with the antlers) and is mostly green, gray, purple, and florescent orange instead of mostly silver and black. But that dude isn't in my comics and I like my original one better, with the real working wrist-shiv deployment, so screw it.
The only huge disappointment with this guy is the sticker sheet. Sure, I like the Autobot logos, and they work well enough on him, but Hasbro also put his original toy's chest deco on there. You know, the little swirly loops that look like chest hair. The problem is, they printed them on a white background, like his symbols, instead of a clear background, so they look pretty terrible on his chest. Reprolabels better solve this one for us. I need those chest swirlies. I'll keep the real swirlie stickers on him until then, because my love for the chest swirlies slightly edges out how terrible I think these stickers look.


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America's top critics do not think "Snow White and the Huntsman" is the fairest of them all.
Universal's big budget re-imagining of the fairy tale classic earned a 47 percent "rotten" score on critics aggregator Rotten Tomatoes, with many reviewers knocking the fantasy's lugubrious pacing and the performances of actresses Charlize Theron and Kristen Stewart.
TheWrap's Alonso Duralde said Stewart's Snow White, here refashioned as a warrior, is too reminiscent of her twitchy "Twilight" character Bella Swann and would have a hard time convincing people to follow her to Forever 21, let alone storm a castle.
Also read: 'Snow White and the Huntsman' Review: Charlize Theron Chews All Scenery Except the Mirror
Duralde was gentler with Theron's wicked queen, but still called the mirror-gazing performance hammy.
"There will be lots of versions of Theron's evil queen running around West Hollywood and Chelsea this Halloween; it's a performance that's about one part Tilda Swinton to 30 parts Faye Dunaway, and it's the sort of over-the-top craziness that spawns midnight screenings for drunken audiences," Duralde wrote.
For Slate's Dana Stevens, the whole enterprise boiled down to one epic missed opportunity.
Also read: 'The Dark Knight Rises' Teases Audiences with Kinky Catwoman Poster
"Snow White and the Huntsman, the first feature from British commercial director Rupert Sanders, has its work cut out for it if it wants to be a truly dull piece of junk—but it manages," Stevens wrote.
Stevens' cohort at the Village Voice, Nick Pinkerton, complained that the film, while visually rich, was incoherent and overly long.
"But for all this Snow White's visual ornamentation, there's no sense of narrative priority—the filmmakers can't see the Dark Forest for the trees," Pinkerton wrote.
However, a few members of the critical choir broke with the pack to praise first-time director Rupert Sanders' visual flair and dark take on the Snow White story.
Also read: How 'The Best Exotic Marigold Hotel' Became This Summer's Surprise Indie Smash
Among those delighted and not dulled by the special effects extravaganza was New York magazine's David Edelstein, who had reservations with the structure of the film, but ultimately found it satisfying.
"Director Rupert Sanders comes from the world of commercials and Xbox games: He's good with images and not good at all at making them flow together, which means lots of choppy swordplay and tacky slow motion," Edelstein wrote. "But the movie's revisionist tone is startlingly enough to carry you along."
Likewise, A.O. Scott in the New York Times, hailed Stewart's revisionist take on Snow White as an ass-kicking leader of men, not just a demure beauty.
"Her Snow White is part of an interesting new breed of warrior princesses — Katniss Everdeen is their current leader — whose ascendance reflects the convergence of commercial calculations and cultural longings. Long may they reign," Scott wrote.


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Remember when companies deployed Nextel phones solely for their push-to-talk (PTT) capabilities? With the press of a button, a caller could enable walkie-talkie-like communications with the office or a co-worker.
PTT technology has kind of fallen by the wayside, but the need for quick and easy voice communication hasn't. Enter HeyTell, a free app that lets you send voice messages to one or more recipients. (That link is for the iOS version; HeyTell is also available for Android.)
When you tap and hold the Talk button, you can record a message of up to 30 seconds. When you're done, the message is immediately delivered to the selected recipients.
Think how incredibly handy that would be for, say, notifying a sales team of an upcoming meeting, or letting your employees know about a new promotion. Sure, you could accomplish the same thing with an e-mail or text message, but your voice can convey a lot more than just raw text. Plus, sometimes it's way more convenient to say what's on your mind than it is to type it.
If there's a catch to using HeyTell, it's that everyone in your circle must have the app on their Android phone or iPhone. (For any contact who doesn't have it, you can send an invitation via e-mail or text.) But once it's installed, it alerts users via push notification when a new message arrives, just like with a text message.
What's more, you can add your location to outbound messages, which is great if you're trying to get a group to convene at a certain spot. ("Lunch meeting today at Chotchkie's on Lexington.")
Amazingly, HeyTell is a free app, though there's one $1.99 add-on you might want to consider: Groups, which lets you create groups of up to 25 people for faster, easier message broadcasting.
Although this doesn't recreate PTT in the strictest sense, it's a great way to exchange voice messages in something close to real time. If you've found a better walkie-talkie app, let me know about it in the comments.


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Paul Caligiuri. Eric Wynalda. Frankie Hejduk. Steve Cherundolo. Marcelo Balboa.
Those five US internationals all have one thing in common: Each played youth ball at Nomads Soccer Club in the suburbs of San Diego. Led by English transplant technical director Derek Armstrong, the club has quietly produced some of the best players to have ever donned a US jersey.
But Armstrong, who coached and played at various levels in the UK before coming to the US in 1980, takes just as much pride in helping players get into college as he does in developing quality players.
"We're very proud of putting people into the college system and giving everyone an opportunity to achieve what they can achieve," Armstrong told MLSsoccer.com. "It isn't just the professional player. We're proud of everybody."
Back when Armstrong was hired as director of coaching in 1980, he was one of the first youth coaches in the United States to be paid – a big moment in the development of the game in this country. Since then, the club has produced a staggering list of alumni. Some, such as Hejduk and Cherundolo, played at the club at a very young age. Others, such as Balboa or Wynalda, spent time at Nomads during their college years.
[inline_node:327379]Armstrong attributed the success to the consistency of the club's leadership. He's been there since the beginning, and much of his staff has been around for a similar length of time.
In his 30 years of service, he's witnessed change across the landscape of youth soccer. But he pointed to two specific instances that have really shaken things up: the emergence of US Club Soccer and the formation of the USSF Development Academy.
"Everything else has crawled along," he said.
The creation of the USSF Development Academy in 2007 forced changes for Armstrong, too. At the time he was also head coach of UC San Diego. Because of the increased demands of the new system, he retired from his college coaching post — a job he had held since 1983 — so he could focus on the Nomads' involvement with the academy.
Compared with some of the other clubs competing in the Development Academy, Nomads is small. Armstrong said this year's expected roster is no more than 500 players. Recently, the club decided that in order to remain competitive in the U-16 and U-18 levels, it would need to develop players from a young age in order to create a pipeline to those two squads. With that comes the need to find more players, and a roster of 500 is one of the biggest the club has ever had.
"We've decided on a policy these last 12 months, with the advent of the academy, we have to have the pipeline coming through from the early stages," he said. "To be competitive at that level, it all depends on how good we are with our development."
That pipeline has produced alumni currently playing in MLS – Gabriel and Michael Farfan in Philadelphia, Eric Avila in Dallas and Hejduk in LA among them.
Nomads continue to impact youth, pro soccer
Paul Caligiuri. Eric Wynalda. Frankie Hejduk. Steve Cherundolo. Marcelo Balboa.


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Midnight trains to Georgia
The Peach State prepares for a political frenzy as a pair of January runoffs determine the balance of the Senate—and the shape of the presidency
The Peach State prepares for a political frenzy as a pair of January runoffs determine the balance of the Senate—and the shape of the presidency
European nations try to stem rising COVID-19 cases while weighing the costs
Dominion Voting Systems and other election software have vulnerabilities, but layers of security guard against widespread fraud
As states certify voter results, Republican hopes fade for Trump's legal challenges to the election
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ATLANTA- Moments before Sen. Barack Obama (D-Ill.) bounded onto the stage at a campaign rally in downtown Atlanta late last month, retired minister and civil-rights icon Joe Lowery offered an opening prayer: "Lord, we are here tonight because when we sing 'My Country 'Tis of Thee,' we see too much misery."
The 2,200 supporters gathered in a ballroom at the Georgia World Congress Center responded with chuckles and scattered applause. But the chuckles turned into a resounding "Amen" when Lowery, 82, compared Obama to John the Baptist. Lowery prayed for the success of his presidential run, concluding "in the name of justice."
Obama finally took the stage two hours after the doors opened and delivered a well-worn stump speech with the enthusiasm and cadence of a preacher. The crowd cheered in agreement when the Democratic presidential candidate spoke of being "my brother's keeper."
Religious language and themes aren't new for the Obama campaign. The Illinois senator has compared himself to a modern-day Joshua who longs to lead the American people into the Promised Land. Earlier this year, Obama told an A.M.E. congregation in Selma, Ala., that he draws encouragement from God's Old Testament words to Joshua to "be strong and have courage, for I am with you wherever you go."
Any candidate needs strength and courage for a presidential run, but Obama recognizes that he also needs faith. He protests the notion that faith and politics must remain separate, and chastises fellow Democrats for abandoning religious ideas in the public square.
Less than three months before the presidential primaries begin, Obama is trailing front-runner Hillary Clinton in the polls, but he is pressing religion more than any of his Democratic opponents: He openly offers his account of converting to Christianity, has delivered at least two major speeches on faith and politics, and is aggressively courting support from churches and individual Christians.
The Obama strategy is key to distinguishing himself from Clinton, who shares nearly identical policy positions on issues like health care, economics, and the war in Iraq. The goal is clear: Gain an edge by tapping into a segment of religious voters that Democrats have largely ignored in the past; insist that conservative Christians should compromise on principle for the sake of consensus. In his words, the "so-called leaders of the Christian right" are "hijacking" faith and "all too eager to exploit what divides us."
Apart from commending conservative evangelicals for combating poverty and for drawing attention to the African crisis in Darfur and over AIDS, Obama makes it clear that he doesn't often agree with the religious right. Yet he has sought consensus among Christian leaders well known in conservative circles-appearing late last year at a church-sponsored event to combat AIDS with mega-church pastor and Purpose Driven Life author Rick Warren.
Obama also strikes themes that resonate with conservative evangelicals. He speaks about the importance of family and individual responsibility in addressing poverty, AIDS, and unwanted pregnancies. He stresses the urgency of cultivating strong fathers in the black community and says the government is no substitute for good dads. He also speaks about the importance of his own family, including his wife of 14 years, Michelle, a Harvard-educated attorney he met while working at a law firm in Chicago. The couple still live in Chicago with their two daughters, ages 9 and 6.
When Obama delivered a speech about faith and politics at the Call to Renewal conference organized by left-leaning evangelical Jim Wallis and others, he told the group that Democrats need to compete for the support of Christians. "Secularists are wrong when they ask believers to leave their religion at the door before entering the public square." But he also challenged conservative Christians to "accept some ground rules for collaboration" with those with whom they disagree.
Specifically, Obama believes conservatives should be willing to compromise on the issues of abortion and civil unions for homosexuals. The candidate vigorously supports both.
In his political memoir The Audacity of Hope, Obama, 46, makes clear that his religious views, like his political ones, are progressive and liberal. Nearly 20 years ago, he joined the United Church of Christ (UCC), a self-described "progressive" denomination that was the first to openly ordain homosexuals. In 2005, the UCC passed a resolution supporting gay marriage. (Like other Democratic front-runners, Obama says he doesn't support gay marriage, but advocates civil unions for homosexual couples.)
Obama and his wife are long-time members of Trinity UCC, an 8,500-member congregation in Chicago that represents the largest predominantly black church in the denomination.
But Obama didn't always identify himself as a Christian. The senator grew up in Hawaii and Indonesia, raised by grandparents and a single mother who later remarried. Obama's father, a Kenyan whom he met only a short time before his death, grew up a nominal Muslim but embraced atheism later in life. Obama's mother encouraged her son to learn about all religions-he attended both Islamic and Catholic schools-but was skeptical of religious systems.
Obama embraced his mother's skepticism and didn't seriously consider religion until after college when he took a job as a community organizer for a group of inner-city churches in Chicago. He visited Trinity UCC on a Sunday morning in 1988 and heard pastor Jeremiah Wright deliver a sermon called "The Audacity of Hope." "And during the course of that sermon, he introduced me to someone named Jesus Christ," says Obama. "I learned that my sins could be redeemed."
Obama says he embraced Christianity and was especially drawn to Wright's emphasis on black liberation theology: The pastor interpreted the Bible as a story of the struggles of black people and emphasized social justice.
"Inside the thousands of churches across the city, I imagined the stories of ordinary black people merging with the stories of David and Goliath, Moses and Pharaoh, the Christians in the lion's den, Ezekiel's field of dry bones," Obama wrote in his autobiography Dreams from My Father. "Those stories of survival, and freedom, and hope-became our story, my story."
Obama's story continued to unfold at Harvard, where he earned a law degree in 1991 and became the first black student to head the prestigious Harvard Law Review. While practicing as a civil-rights lawyer and teaching constitutional law, Obama served in the Illinois state Senate for eight years. In 2004, he became just the third African-American elected to the U.S. Senate since Reconstruction, and his widely praised keynote address at the 2004 Democratic National Convention established him as a rising star in the party.
Today when Obama speaks about faith, he still focuses on human struggle and the need for social change, but he doesn't focus only on race. And since running for the White House he has distanced himself from his pastor's political views: Wright often preaches in scorching terms about "the Great White West," and he declared that 9/11 was the result of violent American policies.
Obama has said the Bible is not "a static text" and says he "must be continually open to new revelations"-and he has acknowledged that those who believe the Bible is inerrant and that it teaches, for example, that abortion is wrong aren't likely to accept his "ground rules for collaboration." So as the campaign reaches out to religious voters, the discussion typically steers clear of such controversial subjects. On a recent Saturday morning at a campaign-organized "faith forum" in rural South Carolina, the subject didn't come up at all.
About 20 people gathered in a meeting room at a small hotel in Greenwood, S.C., mostly from black Baptist churches in the area. At least six staffers from Obama's state campaign met with the pastors and church members to discuss how faith affects politics, and to assure the group of Obama's commitment to Christianity.
Most of the participants expressed concerns over issues like health care and unemployment in the economically depressed region. An elderly pastor with a strong voice and dark blue suspenders lamented his struggles to afford good health care: "Here we live in this big democratic country, and there ain't no medicine for the poor people." He spoke of choosing between buying food or prescription medicine. He recounted sometimes asking the pharmacist to fill only half a prescription so that he could afford it.
Campaign staffers told the group about Obama's plan for health care. The candidate favors a universal health-care proposal similar to those of Democratic opponents Clinton and John Edwards: It requires employers to provide insurance to employees, but also allows individuals to purchase their own insurance from a regulated marketplace of competing health plans.
The plan would also offer incentives for improving preventative care, and provide subsidies for individuals who cannot afford health-care premiums. Obama says the plan would cost the federal government $50 billion to $60 billion a year once fully implemented. Like Clinton and Edwards, he says he'll pay for the plan by allowing tax cuts to expire for those making over $250,000 a year.
Obama concedes his plan is not substantially different from his opponents' plans, except for one thing: The Clinton and Edwards plans would make coverage mandatory for all Americans. Obama says he wants to make sure coverage is affordable before it is mandatory.
Obama also proposes $80 billion in annual tax relief for lower-income Americans and senior citizens. He proposes eliminating taxes on seniors earning less than $50,000 a year, a plan that would affect about 22 million elderly people. He says he would pay for the cuts by raising the rates on capital gains and dividends for wealthy investors.
All of that sounds good to Renea Little, who sits at a small table in the hotel conference room, talking about why she volunteered for Obama's campaign. Little has lived in Greenwood her entire life and is currently unemployed in a region that suffered a severe economic blow with the decline of the U.S. textile industry. She thinks Obama "will bring us all hope."
Little is a member of a nearby Baptist church and says it's important to know that a candidate believes in God. She liked what she heard about Obama's faith during the forum, but when asked if his positions on abortion or homosexuality are troubling to her, Little's countenance slightly falls. She asks in a lowered voice: "Is he for those things?"
Obama has consistently talked about reducing the number of abortions and increasing the number of adoptions, but also consistently supported legalized abortion. As an Illinois state senator during 2001 and 2002, he voted against the Illinois Born Alive Infants Protection Act, a bill aimed at protecting babies who survive abortions.
The senator cited concerns over the legislation's provision for civil and criminal penalties for offending doctors. The legislation failed in Illinois, but a similar bill passed on the federal level in 2002.
Earlier this year Obama condemned the U.S. Supreme Court's decision to uphold the ban on partial-birth abortion, saying he feared it "will embolden state legislatures to enact further measures to restrict a woman's right to choose." But on the trail he rarely mentions abortion, instead focusing on issues more likely to drive the next election; chiefly, the war in Iraq.
Obama repeatedly reminds voters that he was the only leading Democratic candidate against the war from the beginning. He opposed the war in 2002 while still a state senator in Illinois. After winning a U.S. Senate seat in 2004, Obama initially hesitated about supporting a timetable for withdrawing troops. When Rep. John Murtha (D-Pa.) called for such a timetable in 2005, Obama resisted. "I'm not a military man," he told the Chicago Tribune. "I'm not running the war in Iraq."
Last summer, Obama voted against a plan to withdraw troops within a year. One year later, as a presidential candidate, Obama has proposed a very specific timetable for withdrawal: Now he has called for withdrawing a brigade a month, with all combat troops withdrawn from Iraq by the end of 2008.
Clinton and Edwards are also calling for troop withdrawals, and the three front-runners often compete to see who opposes the war most. As with health care and the economy, their plans are much the same. With such similar positions on so many issues so close to the Democratic primaries, Alania Beverly, Obama's deputy political director in South Carolina, admits the race will ultimately boil down to the character of the man-or woman: "It's going to come down to who has the political will to get it done."


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One thing we very much need this session is a change to the CHL laws or property laws similar to what Oklahoma's Gov. Brad Henry signed into law on March 31st 2004. In part, what that law reads is...
"No person, property owner, tenant, employer or business entity shall be permitted to establish any policy or rule that has the effect of prohibiting any person, except a convicted felon, from transporting and storing firearms in a locked vehicle on any property set a side for any vehicle."
I don't think we need exactly this, but something like it would be a great benefit. As it stands now a CHL holder can lose his job, without recourse, if he chooses to travel to work armed - leaving his sidearm in his locked vehicle after arrived at work. This is just wrong. Perhaps a civil suit against an employer of someone, who is seriously injured or killed in route to or from work, when his sidearm might have prevented such, will fix this. But, why should it cost someone his or her life to fix it. Nuts!
I don't think most employers would be against such a law, if I go by a high ranking official in my company. His comments were that they have chosen an unofficial, unwritten and you didn't hear it from me "don't ask - don't tell" policy. He said that if they put this in writing, then they would be open to a civil suit if something bad happened concerning a gun in an employee's vehicle if they had the ability to prohibit it being there. In the past, employee's had arrived at work with rifles in gun racks (trucks) and security simply asked them move them to someplace in the vehicle where they could not be seen, and please don't bring it back (butt covering ending request). This corporate honcho did make the comment that if the CHL law was changed to prevent them from prohibiting CHL holders from having firearms in their cars in a company parking lot, it would suit him just fine because then their corporate rear ends would be covered against a civil suit. "Hey, we followed the law." This doesn't alway work to preventing suits, but it goes a long long way towards thwarting and winning them.
At many company locations there is alternative parking available near by and it doesn't have to be an issue. In my situation however, the next nearest parking area is 13 miles away. I simply choose to travel armed and then lock my sidearm in the glove compartment of my vehicle. My decision, but I would prefer that my peace loving, law-abiding posterior be legally covered.
I think we need something protecting law abiding citizens and CHL holders while having firearms in parking areas when the firearm is; 1) not readily visible from the outside, 2) secured in a locked vehicle or permanently anchored locked device, and 3) as long as it does not violate any state or federal laws.
This should apply to employers, government offices and business owner's general parking areas. Were I work we have two parking areas. One in general which is a semi-unsecured forward area and another that is beyond a controlled gate and security guards. Only an anointed few are allowed to park inside the secured area, but all are welcome to park in the forward general parking area. This would create an alternative for those who have a CHL and do not wish to park beyond the gated and guarded area. I don't think this should apply to private property not open to the public or employees. If you have a situation like this I think it should be OK to prohibit in the secured area as long as alternative parking is available. I think the same could apply if alternative aprking areas were available within a reasonable walking distance (like maybe 100 yards maximum)
If you think this would be worthwhile legislation, please send hand written letters to all of your state representatives and the Texas State Rifle Association - attn. Alice Tripp. Hand written letters have a 10-fold impact over form letters and about a 3-1 effect overtyped letters (so I am told). The TSRA (Texas State Rifle Association) has a web site that has link to your state reps.
My letters will go out before the end of the week and I will send duplicates about a month later.
My 2 Cents - Thanks
What We Need
The Legislative Session is over - here are the results?
Moderator: Charles L. Cotton
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I agree. A law like that here would be nice. My place of employment is not in the best part of the city.
Work banned it right after the law passed. Funny thing is that they banned it because of one person. Kept running his mouth off on how he was going to get his CHL and have a gun with him all the time. Freaked out several people out and they posted the signs. I have a feeling that if he would have kept his mouth shut, it would not be an issue.
Work banned it right after the law passed. Funny thing is that they banned it because of one person. Kept running his mouth off on how he was going to get his CHL and have a gun with him all the time. Freaked out several people out and they posted the signs. I have a feeling that if he would have kept his mouth shut, it would not be an issue.
2 posts • Page 1 of 1


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Solar Forward: Funding Portland's local energy future
Portland City Council voted recently to accept funds from the Oregon Community Foundation's (OCF) Penstemon Fund in the amount of $100,000. The acceptance of these grant funds will enable the installation of a solar electric system at Portland Parks & Recreation's (PP&R) Southwest Community Center (SWCC) and will provide an opportunity for a wider range of Portlanders to engage in the expansion of clean local energy production through a new pay-it-forward effort called "Solar Forward."
"This $100,000 grant from the Penstemon Fund of the Oregon Community Foundation will allow us to install our first 'community solar' system, which will give an opportunity to renters and others who want to do their part to promote renewable energy, but can't install a system on their own homes or apartments," said Susan Anderson, director, City of Portland Planning and Sustainability (BPS).
Introducing Solar Forward: Where community energy meets crowdfunding
OCF has provided grant funds to 'kickstart' construction of the first system at SWCC, but the goal of this pilot is to raise community contributions that will go into Solar Forward to launch Portland's first revolving solar fund.
The fund will finance the installation of future systems on community buildings around Portland. A tax-deductible contribution of any amount will help seed the fund.
"Like a community garden for people without backyards, community solar allows Portland neighbors to support a more resilient Portland with clean energy from the sun," said Claire Carlson, executive director, Solar Oregon. "It also makes a great gift with community benefits."
In return, all of the contributors receive permanent recognition at the host site and the feel-good benefit of paying it forward.
Partners in this effort include Portland Parks & Recreation and Solar Oregon. Due to current utility regulations in Oregon, community contributors are not able to receive their electricity or a bill credit for the energy generation from this installation.
SWCC is offsetting a portion of their electricity consumption with clean power generation that will lower community carbon emissions. This helps Portland meet carbon reduction goals as outlined in the City of Portland and Multnomah County's Climate Action Plan.
Follow and learn how to support this project at www.portlandoregon.gov/bps/solarforward or call Andria Jacob at 503-823-7616.
P.S.-- Understand how solar has grown in Portland over the last 10 years with our new solar map at www.portlandoregon.gov/bps/solarmap


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Winkler, Clinton McKamy (1821–1882)
Clinton McKamy Winkler, Confederate soldier, lawyer, and judge of the Court of Appeals, was born in Burke County, North Carolina, on October 19, 1821, the son of David Tate and Lavinia Gates (Owen) Winkler. Born into the family of a small farmer, young Clinton did not have an opportunity for a formal education. However, at the hands of rural schoolmasters and his mother, who was the daughter of a prominent teacher, his education was not neglected. His family moved to Indiana in 1835, and there he grew to manhood. When he was not yet nineteen, Winkler determined to move to Texas, and he settled in Franklin, Robertson County, in July 1840. He very soon became involved in frontier life, joining numerous expeditions to track down marauding Indians. In 1843 he became district clerk pro tem. While serving in this capacity, he was admitted to the bar at Franklin on April 27, 1844, by Judge Robert E. B. Baylor. He was shortly thereafter elected to a full term as district clerk. Early residents of Navarro County claimed that Winkler was instrumental in persuading the First Legislature to demark Navarro County from Robertson County in 1846. Though the story cannot be documented satisfactorily, Winkler moved to the new county in 1847. Later that year, he was elected to the legislature. He is credited with sponsorship of the legislative act making Corsicana the county seat. On Christmas Eve, 1848, the legislator married a young widow, Louisa R. Smith. They had three children. At the expiration of his term of office, Winkler returned to Corsicana and engaged in the practice of law throughout the next decade. After the election of Abraham Lincoln, Winkler and six other prominent Navarro countians organized the secession movement in the county. Winkler then volunteered for Confederate service and was elected commander of the Navarro Rifles. The Rifles became Company I, Fourth Regiment, Hood's Texas Brigade, the only unit of Texas infantry to serve in Gen. Robert E. Lee's Army of Northern Virginia. Captain Winkler led the company until the battle of Gettysburg, at which he was severely wounded. He was later promoted to major and lieutenant colonel. At Appomattox Winkler was in command of the Fourth Regiment. During the conflict, in November 1861, Winkler's wife died in Texas. He married Angelina V. Smith of Richmond, Virginia, on January 7, 1864. To this second union were born six children. Mrs. Winkler accompanied her husband to Texas after the war. In Corsicana, Winkler became active in civic, legal, and political affairs. He helped organize the community's volunteer fire department and bar association. He became grand master of the state Masonic lodge in 1870 and helped to organize the Hood's Texas Brigade Association two years later. Active in the Democratic party in its attempt to end Reconstruction, Winkler was named state executive committee chairman. In 1872 he was again elected to the legislature. He served only one term, but returned to public life in 1876 as an associate judge of the state Court of Appeals. He remained on the bench until his death in Austin on May 13, 1882. The lifelong Methodist was buried beside his first wife in Corsicana. Winkler County was named in his honor.


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Generalized extreme value distribution
In probability theory and statistics, the generalized extreme value (GEV) distribution is a family of continuous probability distributions developed within extreme value theory to combine the Gumbel, Fréchet and Weibull families also known as type I, II and III extreme value distributions. By the extreme value theorem the GEV distribution is the only possible limit distribution of properly normalized maxima of a sequence of independent and identically distributed random variables. Note that a limit distribution need not exist: this requires regularity conditions on the tail of the distribution. Despite this, the GEV distribution is often used as an approximation to model the maxima of long (finite) sequences of random variables.
μ ∈ R — location,
σ > 0 — scale,
ξ ∈ R — shape.
x ∈ [ μ − σ / ξ, +∞) when ξ > 0,
x ∈ (−∞, +∞) when ξ = 0,
x ∈ (−∞, μ − σ / ξ ] when ξ < 0.
|for x ∈ support
where gk = Γ(1 − kξ),
and is Euler's constant.
where is the sign function
and is the Riemann zeta function
|Ex. kurtosis
In some fields of application the generalized extreme value distribution is known as the Fisher–Tippett distribution, named after Ronald Fisher and L. H. C. Tippett who recognised three different forms outlined below. However usage of this name is sometimes restricted to mean the special case of the Gumbel distribution. The common functional form for all 3 distributions was discovered by McFadden in 1978.[2]
Using the standardized variable , where is the location parameter and is the scale parameter, the cumulative distribution function of the GEV distribution is
where is the shape parameter. Thus for , the expression is valid for , while for it is valid for . In the first case, at the lower end-point, it equals 0; in the second case, at the upper end-point, it equals 1. For the first expression is formally undefined and is replaced with the result obtained by taking the limit as in which case .
If then and ≈ whatever the values of and
The probability density function of the standardized distribution is
again valid for in the case , and for in the case . The density is zero outside of the relevant range. In the case the density is positive on the whole real line.
Since the cumulative distribution function is invertible, the quantile function for the GEV distribution has an explicit expression, namely
and therefore the quantile density function is
Summary statistics
Some simple statistics of the distribution are:
- for
The skewness is for ξ>0
For ξ<0, the sign of the numerator is reversed.
The excess kurtosis is:
where , k=1,2,3,4, and is the gamma function.
Link to Fréchet, Weibull and Gumbel families
The shape parameter governs the tail behavior of the distribution. The sub-families defined by , and correspond, respectively, to the Gumbel, Fréchet and Weibull families, whose cumulative distribution functions are displayed below.
- Gumbel or type I extreme value distribution ()
- Fréchet or type II extreme value distribution, if and
- Reversed Weibull or type III extreme value distribution, if and
The subsections below remark on properties of these distributions.
Modification for minima rather than maxima
The theory here relates to data maxima and the distribution being discussed is an extreme value distribution for maxima. A generalised extreme value distribution for data minima can be obtained, for example by substituting (−x) for x in the distribution function, and subtracting from one: this yields a separate family of distributions.
Alternative convention for the Weibull distribution
The ordinary Weibull distribution arises in reliability applications and is obtained from the distribution here by using the variable , which gives a strictly positive support - in contrast to the use in the extreme value theory here. This arises because the ordinary Weibull distribution is used in cases that deal with data minima rather than data maxima. The distribution here has an addition parameter compared to the usual form of the Weibull distribution and, in addition, is reversed so that the distribution has an upper bound rather than a lower bound. Importantly, in applications of the GEV, the upper bound is unknown and so must be estimated, while when applying the ordinary Weibull distribution in reliability applications the lower bound is usually known to be zero.
Ranges of the distributions
Note the differences in the ranges of interest for the three extreme value distributions: Gumbel is unlimited, Fréchet has a lower limit, while the reversed Weibull has an upper limit. More precisely, Extreme Value Theory (Univariate Theory) describes which of the three is the limiting law according to the initial law X and in particular depending on its tail.
Distribution of log variables
One can link the type I to types II and III the following way: if the cumulative distribution function of some random variable is of type II, and with the positive numbers as support, i.e. , then the cumulative distribution function of is of type I, namely . Similarly, if the cumulative distribution function of is of type III, and with the negative numbers as support, i.e. , then the cumulative distribution function of is of type I, namely .
Link to logit models (logistic regression)
Multinomial logit models, and certain other types of logistic regression, can be phrased as latent variable models with error variables distributed as Gumbel distributions (type I generalized extreme value distributions). This phrasing is common in the theory of discrete choice models, which include logit models, probit models, and various extensions of them, and derives from the fact that the difference of two type-I GEV-distributed variables follows a logistic distribution, of which the logit function is the quantile function. The type-I GEV distribution thus plays the same role in these logit models as the normal distribution does in the corresponding probit models.
The cumulative distribution function of the generalized extreme value distribution solves the stability postulate equation. The generalized extreme value distribution is a special case of a max-stable distribution, and is a transformation of a min-stable distribution.
- The GEV distribution is widely used in the treatment of "tail risks" in fields ranging from insurance to finance. In the latter case, it has been considered as a means of assessing various financial risks via metrics such as Value at Risk.[3][4]
- However, the resulting shape parameters have been found to lie in the range leading to undefined means and variances, which underlines the fact that reliable data analysis is often impossible.[6]
- In hydrology the GEV distribution is applied to extreme events such as annual maximum one-day rainfalls and river discharges. The blue picture, made with CumFreq, illustrates an example of fitting the GEV distribution to ranked annually maximum one-day rainfalls showing also the 90% confidence belt based on the binomial distribution. The rainfall data are represented by plotting positions as part of the cumulative frequency analysis.
Related distributions
- If then
- If (Gumbel distribution) then
- If (Weibull distribution) then
- If then (Weibull distribution)
- If (Exponential distribution) then
- If and then (see Logistic_distribution).
- If and then (The sum is not a logistic distribution). Note that .
See also
- Extreme Value Theory (Univariate Theory)
- Fisher–Tippett–Gnedenko theorem
- Generalized Pareto distribution
- German tank problem, opposite question of population maximum given sample maximum
- Pickands–Balkema–de Haan theorem
- Muraleedharan. G, C. Guedes Soares and Cláudia Lucas (2011). "Characteristic and Moment Generating Functions of Generalised Extreme Value Distribution (GEV)". In Linda. L. Wright (Ed.), Sea Level Rise, Coastal Engineering, Shorelines and Tides, Chapter-14, pp. 269–276. Nova Science Publishers. ISBN 978-1-61728-655-1
- McFadden, Daniel (1978). "Modeling the Choice of Residential Location" (PDF). Transportation Research Record (673): 72–77.
- Moscadelli, Marco. "The modelling of operational risk: experience with the analysis of the data collected by the Basel Committee." Available at SSRN 557214 (2004).
- Guégan, D.; Hassani, B.K. (2014), "A mathematical resurgence of risk management: an extreme modeling of expert opinions", Frontiers in Finance and Economics, 11 (1): 25–45, SSRN 2558747
- CumFreq for probability distribution fitting
- Kjersti Aas, lecture, NTNU, Trondheim, 23 Jan 2008
- Embrechts, Paul; Klüppelberg, Claudia; Mikosch, Thomas (1997). Modelling extremal events for insurance and finance. Berlin: Springer Verlag.
- Leadbetter, M.R., Lindgren, G. and Rootzén, H. (1983). Extremes and related properties of random sequences and processes. Springer-Verlag. ISBN 0-387-90731-9.CS1 maint: multiple names: authors list (link)
- Resnick, S.I. (1987). Extreme values, regular variation and point processes. Springer-Verlag. ISBN 0-387-96481-9.
- Coles, Stuart (2001). An Introduction to Statistical Modeling of Extreme Values,. Springer-Verlag. ISBN 1-85233-459-2.


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I'll score it all in the next couple of days. I'm sick of waiting for a result.
Still going with the scores and such, but I did notice one thing worth mentioning right now - Grant NEVER said "but this leg is not over" at the Bone Church, only "but it's not over", and between Chris's comment about winning the worst leg of all and Grant's confirmation at the start of the season that there were twelve legs in the race, it's VERY clear that they were two separate legs without a Pit Stop (a la TAR18), not one uberleg (a la TAR6). Therefore, I'm going to count the questions we were planning to carry over from Leg 7 as valid for the Bone Church arrivals, not for the arrivals at Dunajec Castle.
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Ringerike Gjestegård offers accommodation in attractive rooms, all with ensuite bathrooms. We have 15 rooms with a total of 30 beds. Central location by highway E16, at the exit for Hønefoss.
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