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Online Encyclopedia
Spaceship Earth
The phrase 'spaceship earth' is believed to have been derived from a passage in Henry George's best known work, Progress and Poverty (1879).
In Bk IV, Ch 2 occurs the following passage: "It is a well-provisioned ship, this on which we sail through space. If the bread and beef above decks seem to grow scarce, we but open a hatch and there is a new supply, of which before we never dreamed. And very great command over the services of others comes to those who as the hatches are opened are permitted to say, "This is mine!" "
Last updated: 02-21-2005 12:26:07

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A head-to-head comparison of two biologic therapies used to treat a subset of patients with advanced kidney cancers provides much-needed clarity on the preferred method of first-line treatment. The phase II ASPEN trial, led by researchers at the Duke Cancer Institute, is the first and largest trial to compare the effectiveness of treatments used for metastatic non–clear cell kidney cancers, a group of malignancies that account for about 20% of kidney cancers. The findings will be presented June 1 at the ASCO 2015 Annual Meeting (Abstract 4507).
"We have had very little evidence to guide clinical decision-making and drug choice for patients with non–clear cell renal cancer," said Andrew Armstrong, MD, Co-Director of the Genitourinary Oncology Research Program at Duke Cancer Institute and the study's lead author. "These cancers are actually very different diseases, with different genetics, so we cannot have a one-size-fits-all approach."
Study Findings
In their study of 108 patients, Dr. Armstrong and colleagues focused on three forms of non–clear cell kidney cancers: metastatic papillary, chromophobe, and unclassified. The patients were randomly assigned to receive one of the two approved treatments that are typically used—everolimus (Afinitor) or sunitinib (Sutent)—until their tumors progressed.
The researchers found that sunitinib was superior overall compared with everolimus at prolonging the amount of time before tumors regrew but at a higher rate of severe toxicity. Sunitinib was more effective for papillary-type kidney cancers and for better-prognosis patients. Patients with chromophobe and poor-risk tumors treated with everolimus had a longer median progression-free survival than patients treated with sunitinib.
"These drugs have different mechanisms of action, so it makes sense that they would have different response rates for these tumors, which are essentially different diseases genetically," Dr. Armstrong said. "This information provides physicians sound data to guide treatment for their patients based on the kind of cancer identified."
More than 100 study patients also donated tumor tissue, establishing the largest repository of non–clear cell kidney cancer tissue to aid development of new drugs and biomarkers for the disease.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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Bronchitis Meds: Bronchitis vs Asthma
Bronchitis and asthma are a few of the common medical problems faced by people all over the world. Each these types of conditions are associated with the respiratory system of your body, but there are a few basic distinctions between the two, and some similarities as well.
Bronchitis In most cases, acute and chronic bronchitis share the same symptoms. These might include: Apart from the aforementioned symptoms, one that may be particular in order to chronic bronchitis is frequent occurrence of infections such as cold and flu, and worsening of the cough. Additionally, excessive breathing problems in the mornings and damp weather is a classic sign of longterm bronchitis symptom.
Wet Cough is the Frustrating State that Makes Your Ribs, Back as Well as Arms Harm
Your neck will be blister and all the people you will be bothered by the noise. It is a respiratory infection and ordinarily starts off as a dry cough, after which graduates to the "wet cough" stage. There might be several reasons for this cough to occur and the procedure depends on these reasons.
Medical Attentionthe Above Remedies Work for Many Throat Problems
But, it would be advisable to consult a physician within the following situations. Avoid eating hot and spicy, hot, or even oily meals. Drinking a lot of fluids when experiencing tickly throat, helps you to recover the throat faster. In most sore throat problems, gargling along with the above cures, will give you good relief. If you are going out, then wear warm clothes and include the neck with a scarf or stole.
To ensure the safety of the fetus or the unborn child, pregnant women should make use of medications only under the supervision of the physicians. Cough drugs contain several ingredients, and so, it is better to confirm that each of these ingredient is safe, by talking to a physician or physician. Pregnant women can also talk to their doctors regarding the use of sucking lozenges that contain natural ingredients such as darling and glycerol, for managing moderate to moderate cough.
Cough Medication and Pregnancy
Is usually suggested to minimize the use of drugs while pregnant, as some drugs can have an adverse effect on the developing embryo. The most typical and also the most popular cough suppressants are those which contain dextromethorphan. Dextromethorphan is simply a narcotic, but it is not addictive. It can be found in many over-the-counter cough medications.
- Flu: Flu, also known as the flu, is a respiratory disease.
- In this condition, the respiratory system membranes get inflamed, causing increased mucus production.
- This particular constricts airways, resulting straight into upper body congestion.
Bronchitis is the Result of Contamination in the Respiratory Tract
It leads to inflammation in the air passing between the nose and the lungs. There's two different forms of bronchitis. They are acute bronchitis as well as chronic bronchitis. The names have likeness, they are completely different health problems having different symptoms. Although the effect of serious bronchitis takes a couple of days, chronic bronchitis has a long term effect on the health.
Treatment for Smooth in Lungs and Heart Failure
In modern times, far better medications have been made available to deal with fluid filled lungs. Antibiotics help get rid of the infection. Improved quality of pacemakers and implantable defibrillators help improve the function of the heart and lungs. Diuretics usually are recommended as they help reduce the fluid in lungs. Some drugs improve the pumping capacity of the heart. Surgery can repair blockage of the coronary arteries, a valve issue, a congenital heart defect, or even a too thick pericardium. An opportunity of heart transplant can be obtained when the heart's ability to pump blood will be permanently marred. Prompt supply of oxygen or synthetic ventilation is often a part of the emergency remedy. The therapy should be so designed that the fluid should not again get accumulated in the lungs.
- Asthma Asthma is caused when the airway inside the lungs through which the air passes, become limited as well as narrow.
- This makes it difficult for the oxygen to pass through and so results in a strain in the chest area.
- This can be followed by extreme bouts of cough (with phlegm), the impression of breathlessness, and tightening of the chest muscles.
- There is then irritation caused as well as an obvious inhaling and exhaling problem.
- Asthma is actually due to associated with the, smoke, allergic reactions to certain substances in the air and stress.
- Though asthma is a serious disease, it can be treated effectively, offered it is diagnosed promptly.
Bronovil: All-Natural Treatment for CoughBronovil Cough Relief Package consists of calming homeopathic drops, and all-natural supplement, created to help target the source of upper respiratory inflamation. Bronovil includes only the pharma-grade quality active ingredients that have been scientifically formulated to deliver the best results. Bronovil's active ingredients have been used for hundreds of years to support healthy lungs and respiratory system, helping in reducing inflammation and cough and support respiratory health. Decreasing inflammation and supporting healing has been shown to ease the pain and flare-ups associated with upper respiratory infections.
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Asthma Asthma has no identifiable causes hence, it is regarded as idiopathic. While bronchitis has a few specific set of brings about, doctors aren't sure the reason why some people contract asthma, while others will not, even if both these groups are leading an identical lifestyle. Assumptions are usually that, genetic factors, as well as environmental factors may be the contributing factors. Doctors possess, however, been able to identify factors which may trigger a great asthma attack. These are: Symptoms.
Antibiotics cannot cure bronchitis the result of a virus. Instead, you should choose for several supportive measures that can help reduce the signs. Turmeric extract, ginger, garlic, etc. display prescription antibiotic, anti-inflammatory, and also antiviral properties. These people market fast recovery. The particular tips mentioned above are helpful to deal with viruslike bronchitis in your own home, but you ought to consult your physician if the symptoms do not subside inside of a couple of days. Considering the overall health as well as the other current health conditions, the physician may suggest a cough suppressant or perhaps a great inhaled bronchodilator.
Runny Nose and Sore Throat
Runny nose is the sort of symptom that causes a lot of uneasiness to the patient. Repeated coming from the nose should be done in a gentle method otherwise they this may get hurt. Due to the tenderness of the throat, the words will get hoarse.
- Pain The disease tends to make the bones, joints, muscles, and nerves very sensitive, leading to a lot of pain.
- That is why, neck discomfort, muscle discomfort, and back pain are often observed in this condition.
- It's possible to get regular bouts of head ache as well.
- Some people also whine about a kind of uninteresting upper body pain that occurs due to difficulty in inhaling and exhaling and excessive coughing.
- Chronic bronchitis can be prevented by avoiding contaminants in the air, like dust and smoke.
- Prevent viral infections by maintaining personal hygiene and by staying away from people with cold and flu.
- Early diagnosis and treatment can cure this disease to some extent.
- Therefore, it is very important to find medical health advice at the earliest, if you are going through some of the symptoms of chronic bronchitis.
- Symptoms Description of symptoms and also physical examination help diagnose the problem.
- No test is required.
- Cigarette smoking, inhalation of smoke, gases, or airborne dirt and dust can worsen the condition.
- In the event that care is not obtained, the problem can lead to pneumonia.
- Asthma The symptoms may greatly fluctuate with individuals.
- A few may have symptoms too moderate to bother, while for some of the signs and symptoms may suggest an urgent situation.
- Some people may have the attack only during the night, and others may have frequent attacks during the day.
- Several common symptoms may well include: Treatment
- Symptoms Parents can observe that their toddler is suffering from dry drowning or not, only if they have proper understanding of the symptoms.
- Subsequent are most commonly seen signs and symptoms in toddlers:
To summarize, bronchitis could be acute or chronic, where the first one usually improves on its own, while the other calls for long-term medical care. On the other hand, asthma is a longterm medical problem that cannot be corrected when it begins. However, for both these conditions, medication is available to help improve the quality of life of the victim.
How to Cure Bronchitis and Cough Naturally - Best Home Remedies for Cough and Bronchitis
How to cure bronchitis and cough naturally. Best home remedies for cough and bronchitis. The time of viral and bacterial infections has come – they are ...
Asthma Asthma refers to a condition which can be characterized by the narrowing and swelling of the airways or bronchial tubes that have oxygen to and from the lungs. This particular makes inhaling and exhaling hard. Unlike, the above condition, it's only chronic and calls for long-term treatment. In order to add to this, it is incurable. For a lot of, the condition may be nothing more than a nuisance, although for some, it may lead to a life-threatening asthma attack. Although there is no cure for this respiratory problem, there are treatment methods to help manage and manage the signs and symptoms.
- Remedy # 1 - Hardened Sugar The worst part about that dry cough?
- The dryness that ensues.
- An individual cough and you only end up hurting the neck with each and every jerky action.
- The throat is like there is an individual in there drilling with a machine or something like that similar.
- The first thing you do is provide this into handle.
- Suck on microbes sugars.
- It'll lubricate your tonsils by producing more spit and getting you to take it.
- This is a good substitute for chocolate and lozenges and one of the best ways of getting rid of a scratchy throat.
The symptoms should not be neglected, and also necessary actions with regard to treatment should be taken on time to avoid virtually any serious problems like pneumonia. Doctors prescribe appropriate treatments to get relief from temperature and also the persistent cough. You ought to drink plenty of fluids to avoid dehydration. It is a highly contagious disease, that may spread from one person to another through air or direct contact of the things that are used by the patient. Therefore, if you are affected by the disease, make sure you cover your own face while coughing and sneezing. Also, if you are going in close proximity to a patient of severe bronchitis, then you ought to wear a mask and wash your hands as frequently as possible in order to prevent dispersing the infection.
Cough This is the first indicator which is noticed, and it generally last for the longest period of time. Hacking and coughing as a result of severe bronchitis has a distinguishing sound. In the initial stage, the cough remains dry, but later this brings out mucus. The color of the mucous may vary from obvious in order to yellow to green. If the coughing persists for a long time which is repeated quite frequently, then it can cause contraction of the thoracic cavity and also spots of blood might be found with the mucus.
Herbs help to heal and treat the body naturally, without causing significant health repercussions. However, with all the different herbs to deal with bronchitis, it is best to consult a qualified herbal practitioner, because diverse natural components may not be compatible with each other.
Causes of Bronchitis and Asthma
Bronchitis If we all speak of the acute form of the problem, after that it generally follows a standard chilly infection. The virus that causes cold, is also known to give rise to this condition, in almost 90% of cases. However, this is always not the case. The actual bronchial pipes may get painful in reaction to active and passive tobacco smoking, exposure to family cleaners, dusts, fumes, as well as smog. Specific underlying conditions such as Gastrointestinal Flow back Disease (GERD) can also be an offender.
Chronic bronchitis is the irritability and inflammation of the airways in the lungs. This inflammation leads to the formation of heavy mucus in these airways (bronchial tubes). Repeated infections trigger deposition of mucus, that blocks the airways, causing breathing difficulties. Other signs and symptoms include persistent cough with sputum, and also wheezing. In people, who are affected with chronic bronchitis, these symptoms persist longer trips, and recur many times in a year. Smoking is the most common cause of this disease, and includes second-hand smoking too. Chronic bronchitis brings about include bacterial or viral infections, allergy symptoms, and environmental pollution.
Other Symptoms
There could be other symptoms accompanied by those mentioned above. Choking or gagging is a manifestation of this condition, and if this lasts for more than two minutes, after that it is a sign of danger. Sweaty skin or change in color of skin tend to be some other signs which may be noticed. A blue tinge on the lips or perhaps a pale-bluish coloring on face will be a crucial symptom. This is an indication of lack of oxygen in the blood. In some cases, toddlers shed their own consciousness.
Excessive Coughing
Whenever toddlers swallow water unintentionally, they will start coughing as though in order to throw up the water. If this coughing lasts for a longer time than usual, say up to half an hour, it is possible that the ingested water has arrived at the lungs. Parents must look out if any other connected signs occurs in addition to this. One other thing to be noted is that they also cry a great deal and rub their eyes frequently when water has been ingested.


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The mystery of hard and soft inquiry and how to avoid one -OVLG – There is a division in the type of inquiry done on credit reports.. A hard inquiry done, stays on your report for a significantly long time, say.
Does Earnest Money Count Towards Down Payment Shopping Around For Mortgage 80-10-10 loan 80-10-10 combination loan |- Piggyback Loan | Santander Bank – If you've found your dream home, but the 20% down payment is a stretch, consider Santander Bank's 80-10-10 Combination Loan., Also known as a piggyback loan, which an 80-10-10 Combination Loan combines a mortgage with a variable rate home equity line of credit (HELOC) to lower your down payment.How Long Do Hard Inquiries Stay On Credit Best Credit Cards for Good Credit – The good news is that you're in the home stretch, and if you stay on the right. yourself in the foot with hard credit inquiries. These inquiries become less of an issue the older they are, so a.How Long To Hard Inquiries Stay On Your Credit Report Refinance Cash Out Texas Fast Cash: How Taking Out a Payday Loan Could Land You in Jail – Tillman took on more payday loans to. emanate from Cash Biz, which appears to have found a way around the prohibition on prosecuting "held" or post-dated checks. Most payday loan companies in Texas.How to remove hard credit inquiries from Your Credit Report – How long do hard inquiries stay on your credit report? hard inquiries can remain on your credit report for up to 2 years. Each time an inquiry is made, it is recorded by each of the three credit bureaus – Equifax, Experian, and TransUnion.Where To Get A Loan With No Job How to Get a Personal Loan with Bad Credit or No Credit – Personal Loans For People With Bad Credit Or No credit. bad credit or no credit makes it tough – but not impossible – to get a loan. credit unions, home equity and peer-to-peer loans or even debt consolidation with no loan could improve your credit rating and increase your future options.How to Shop for a Mortgage | Sapling.com – Step. Choose your mortgage rates and payment schedule. A fixed program keeps the same interest throughout. An adjustable rate mortgage typically starts out with a lower interest rate but can change, which generally means that it could change up or down periodically with lower rates for shorter periods, depending on the structure of the mortgage.You must substantiate the source of each deposit for the lender to count it in qualifying. When buying a house, you deposit earnest money into an escrow-holder account, which goes toward your down.
How Long Will A Hard Inquiry Stay On Credit Report. – Hard credit inquiries can stay on your credit report for a maximum of two years. However, they'll only actually impact your FICO score for one year, and the ding to your score will be minimal-typically within 1.
Becky Lynch Has Become WWE's Top Star, but How Long Will It Last? – To WWE's credit, they have stuck with The Man as a featured act. However, the recent roll she's been on should be a positive sign that her future will remain bright as long as she can stay the.
Stay A Inquiries Credit Report Hard On How Do Long – · hard credit pulls stay on your report for 2 years, but they have no effect after 6 months in most cases. After the 12 months are up, how do I know those hard inquiries on my credit are not affecting me. Hard credit inquiries can stay on your credit report for a maximum of two years.
Too Many Credit Inquiries on Your Credit Report? Here's What. – Credit inquiries are of two kinds – hard and soft. Hard inquiries occur when you grant a lender permission to pull your credit report with the hope that you'll be able to secure a loan of some kind, such as car loans, credit cards, home loans etc. Soft inquiries occur when you or your existing creditors check your credit report.
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Credit Checks: How Credit Report Inquiries Affect Your Credit. – Credit Checks & Inquiries Will my FICO Scores drop if I apply for new credit?. If your [FICO Scores] change, they probably won't drop much. If you apply for several credit cards within a short period of time, multiple inquiries will appear on your report.
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How Long Do Hard Inquiries Stay On Credit – FHA Lenders. – · If you want to protect your credit score and ensure it stays as high as possible, then it's important to know how different credit inquiries can change your credit score.Find out the difference between a soft inquiry and a hard inquiry, and how long credit inquiries stay on your credit report.


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- n.In a criminal investigation, requesting DNA samples from a large number of people in an area where the crime is thought to have occurred or where the suspect is thought to be living.Example Citation:On Wednesday this week, police canvassed the west-end streets where Holly was last seen, asking men "over a certain age" and who met certain criteria for saliva swabs. ...Experts say such massive DNA sweeps can have a sobering social and legal price.Besides eroding civil liberties and tearing neighbourhoods apart, a sweep — known as a "blooding" — can compromise the value of any DNA evidence it yields."The police think they are being very clever, but proceeding this way could very well jeopardize their case down the road," said Sanjeev Anand, a law professor at the University of Alberta.— Allison Dunfield and Kirk Makin, "Random DNA sampling questioned," The Globe and Mail, May 23, 2003Earliest Citation:And although "The Blooding" is set in England, it covers familiar Wambaugh turf: There's a host of material on police work, stressed-out cops, and the mind of the psycho killer. But in many ways the real story, in Wambaugh's eyes, is about "genetic fingerprinting."This case marked the first time that a murder was solved by the new procedure, developed by Dr. Alec Jeffreys at Leicester University in 1984. It allows investigators to read a individual's genetic code in a drop of blood or saliva or semen, and use that code to track down the criminal.That's just what the police in Leicestershire did: Stymied, they tried this new procedure and ended up "blooding", the English term for taking blood samples, more than 4,500 males to find the killer.— Laurence Chollet, "The cop-turned-writer on the beat," The Record, February 21, 1989Notes:The word blooding, in the sense of "the letting of blood," actually dates to 1597. In the criminological context, it originally meant, simply, "taking a large number of blood samples." The purpose was to analyze the blood to do genetic fingerprinting (1984) — comparing each person's DNA with DNA samples obtained from a crime scene. Nowadays, as the example citation makes clear, blooding has the more general definition of obtaining DNA samples by any method, including saliva.The term was first used in 1987 by English police investigating two murders: the so-called "Narborough Village murders." These killings were the subject of Joseph Wambaugh's 1989 book The Blooding and (as the title suggests) he highlights the term throughout the book:The decision was made, and announced the day after New Year's 1987, that the murder inquiry was about to embark on a "revolutionary step" in the hunt for the killer of Lynda Mann and Dawn Ashworth. All unalibied male residents in the villages between the ages of seventeen and thirty-four year would be asked to submit blood and saliva samples voluntarily in order to "eliminate them" as suspects in the footpath murders...The cops quickly began to refer to their testing sessions as bloodings.— Joseph Wambaugh, The Blooding, William Morrow and Company, 1989Related Words: Categories:
New words. 2013.
Look at other dictionaries:
Blooding — Blood Blood, v. t. [imp. & p. p. {Blooded}; p. pr. & vb. n. {Blooding}.] 1. To bleed. [Obs.] Cowper. [1913 Webster] 2. To stain, smear or wet, with blood. [Archaic] [1913 Webster] Reach out their spears afar, And blood their points. Dryden. [1913 … The Collaborative International Dictionary of English
blooding — /blud ing/, n. Chiefly Brit. (in fox hunting) an informal initiation ceremony in which the face of a novice is smeared with the blood of the first fox that person has seen killed. [1590 1600; BLOOD + ING1] * * * … Universalium
blooding — blÊŒd n. fluid which flows in the veins and arteries; life; murder, bloodshed v. let blood, drain blood for medical purposes … English contemporary dictionary
blooding — present part of blood … Useful english dictionary
DNA profiling — Not to be confused with Full genome sequencing. Forensic science … Wikipedia
List of Darkwave releases — A * A Covenant of Thorns · Hallowed Hollow (1999) * A Covenant of Thorns · If The Heavens Should Fall (2004) * Amygdala · Memento Mori (1997) * And Also the Trees · Virus Meadow (1986) * Anne Clark · The Sitting Room (1982) * Arcana · Le Serpent… … Wikipedia
The Edge Chronicles — Author(s) Paul Stewart Ill … Wikipedia
Renee Olstead (album) — Infobox Album Name = Renee Olstead Type = Album Artist = Renee Olstead Released = May 25, 2004 Recorded = ??? Genre = Jazz Length = 44:18 Label = Warner Bros. Records Producer = Humberto Gatica Reviews = *Allmusic Rating|3|5… … Wikipedia
The Danse Society — Origin Barnsley, England Genres Gothic rock Electronic Post punk Years active 1981–1987; 2011 present Labels Society R … Wikipedia
The Lost Barkscrolls — Author(s) … Wikipedia


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High school roundup: Trinity baseball splits doubleheader at Gulf Shores
The Trinity baseball team lost to Alexandria 9-2 and beat Winfield 7-1 on Wednesday to finish 2-2 at the Gulf Shores Classic
Trace Johnston and John Hall each had two RBIs for the Wildcats .
Charlie Leisy picked up the win against Winfield.
Trinity will host Montgomery Academy at 4 p.m. Monday.
Jeff Davis 9-9,
Russell County 4-5
Jeff Davis (14-6) swept Russell County in a doubleheader Tuesday.
In the first game, Derrick Livingston and Brian Davison had two RBIs each, and Davison was also the winning pitcher.
In game two, Davonta Waller had three RBIs, Shane Osborne had three RBIs and Elvin Lowe was the winning pitcher.
Hooper 16,
Altha (Fla.) 3
MARIANNA, Fla. – Winning pitcher Patrick Knockemus gave up four hits, one walk and struck out two in four innings.
Dezmond Howard had five hits, six RBIs and a stolen base. Bailey Evans had three hits with an RBI, and Knockemus had two RBIs.
Hooper Academy will play a doubleheader against Northside Methodist in Dothan at 2:30 p.m. Monday.
Prattville 6, Ardmore 5
GULF SHORES – Taylor Adams got the win for Prattville. Charlee West had a home run.
Prattville 3,
Springville 1
GULF SHORES – Emma Hindi was the winning pitcher for Prattville.
Prattville (23-8) plays Stanhope Elmore on Tuesday.
— From staff reports


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COVID-19 Updates
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Theodore Friedmann, A.B., M.D.
University of Pennsylvania and M.A., University of Oxford. Dr. Friedmann continues to study Lesch Nyhan Disease (LND), a neuro-developmental disease. His lab is concentrating on microarray and proteomic characterizations of human fibroblasts derived from LND patients, and of affected brain regions of the HPRT gene knockout mouse model. Dr. Friedmann's lab has identified a number of genes and gene families that are aberrantly expressed in LND, and is presently examining their potential role in the development of the disorder's neuropathology. The lab is using microarray and proteomic approaches to characterize the molecular basis for the defect in the basal ganglia dopamine pathways by beginning to characterize the molecular events that accompany the differentiation of human embryonic stem cells toward the dopaminergic neuronal phenotype. Dr. Friedmann is continuing to study the assembly and gene transfer properties of synthetic virus-like nanoparticles (virosomes), and the molecular mechanisms of growth enhancement by the growth factor IGF-1 in cultured cells and in mice in vivo. In addition, he has continued an extensive series of studies in vitro and in vivo of the mechanism of action of insulin-like growth factor (IGF-1), using gene expression and proteomic approaches. As part of that research program, he has established a bioinformatic facility under the sponsorship of the World Anti-Doping Agency (WADA) that will coordinate the worldwide research program of growth factors and related functions under the auspices of WADA.
The Friedmann laboratory has long been interested in the development of the concepts and techniques of human gene therapy. These interests have taken the form of work in a variety of gene transfer vector systems, most notably the development of the VSV-G pseudotyping methods of retroviruses and more recently the development of self-assembled nanoparticles that enhance gene transfer of naked plasmids or liposomes through the incorporation of envelope protein receptor ligands such as VSV-G or other viral envelope glycoproteins. Previous disease models of interest have included neoplastic, cardiovascular and CNS disorders and now focus on Lesch Nyhan Disease, a neuro-developmental disorder caused by deficiency of the purine biosynthetic enzyme hypoxanthine guanine phosphoribosyltransferase (HPRT) and associated with disordered dopamine neurotransmission in the brain. We are approaching this complex monogenic disease by extensive characterization of the effects of HPRT gene mutations on global gene expression patterns and on the proteome of affected tissues. To understand how the brain development of the dopamine neurotransmitter system goes awry in HPRT deficiency, we are now applying these molecular methods to a study of normal and HPRT-deficient human embryonic stem cells as they differentiate into dopaminergic neurons.
We are also currently carrying out similar extensive studies of the effects of growth factors and anabolic steroids on gene expression and on the proteomes of muscle cells in culture and on mouse muscle and other tissues in vivo. These studies are aimed partly at developing molecular screening methods for gene-based doping in sport.
Our current studies concentrate on the mechanisms of the dopamine deficit in Lesch Nyhan Disease and on identifying the possible defect in that disorder of differentiation of embryonic stem cells (ES) and neural stem cells to the dopaminergic phenotype. Toward that goal, we are examining the global patterns of gene expression and the proteomes of HPRT-deficient tissues and cells from the HPRT-knockout mouse model of Lesch Nyhan Disease (LND), and we have identified a number of candidate genes whose expression seems to be correlated with the in vitro differentiation of the parent ES cells toward the dopaminergic neuron phenotype. We wish to use these methods to identify the mechanisms underlying the presumed aberrant dopaminergic development in LND and to use this knowledge to design methods for producing dopaminergic neurons in vitro from embryonic stem cells and from neural stem cells. We are continuing our biochemical and functional studies of these genes and their role in the HPRT-deficiency neurological phenotype, and in particular the possibility of aberrant electron transport and mitochondrial dysfunction in the HPRT knockout mouse model of LND. Our laboratory is also pursuing extensive studies on the effects of insulin-like growth factor (IGF-1) and several other growth factors on global gene expression and on the proteomes of cultured myoblasts and on tissues in mice treated with growth factors. We have identified very complex interactions among several gene families that respond to in vivo exposure to IGF-1 and are carrying out genetic and biochemical studies to We are continuing our studies examining the in vitro assembly of virus-like nanoparticles and virosomes in an effort to produce efficient and targeted non-viral gene transfer methods.


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I am receiving an error that has plagued me for the past year. Our SolidWorks supplier has not been able to determine the problem. The end result was that "SolidWorks is not network friendly" and a recommendation to purchase SolidWorks EPDM which is not an option for us with only one user. When I run a simulation study of a model more than once, I get errors that display following the simulation study run. I get one of the following errors. After clicking OK, I get no results and have to re-run the study. I have to run the study up to 8-10 times before I get no error and I can see results. This is a problem when our larger studies can take a long time to run and a nuisance when running small studies.
- Access to CancelSolverMenuStatic1.dat was denied
- Access to CheckBoxStatusStatic1.dat was denied
- I am currently running SolidWorks 2015 + Simulation Premium.
- This occurs on all computers in our office. However, I am the only SolidWorks user.
- This does not occur when the part file is on the local drive. Our project files are located on a shared network for ease of access and backup. This makes me think that this is a network problem.
- The two files that are referred to in the error are located in the same directory as the part and study files.
- I have tried deleting the two files between runs but still get the error.
What are your thoughts? I cannot find a single thing when I Google this error. Thank you for your help.
Gabriel Molina


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NZ Super Fund Seeks New Zealand Investments
October 7, 2015 New Zealand Finance
The New Zealand Super Fund is looking for new local investment, but has trouble finding new opportunities which meet its requirements.
The New Zealand Super Fund is actively looking for more New Zealand investments, according to comments made by the Chief Executive Adrian Orr at the release of the Fund's annual report.
The New Zealand Super Fund currently has a total of NZD 4.4 billion in investments in New Zealand, out of a total investment portfolio of NZD 29.54 billion.
The current domestic investment level of NZD 4.4 billion is higher than in 2014 when the investments were only NZD 3.7 billion.
While the Fund is looking for new domestic investment opportunities, it was also noted that there are not many opportunities for investment that meet the requirements for scale and return.
However, Adrian Orr added that the Fund is in a good position to enter any investment possibilities that may arise, as it has access to large and quickly capital and does not need to receive approval from the Overseas Investment Office, and, in addition, the participation of the Fund can help the invested equity grow due to improvements in branding.
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USilio is the IT Management Console for Supremo and Uranium Backup.
One of its most important functionalities is that it's able to work as an online synced address book for Supremo.
It's really easy to connect your Supremo address book to USilio and you can also import to USilio all your actual offline address book.
You need to register a USilio account – free – before performing the following steps.
Launch Supremo and open the address book. Then specify your USilio credentials:
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Перечень Продуктов
Главная > Перечень Продуктов > Спортивные Сумки > Полиэстер Спортивные Сумки > Printing Trendy Travel Gym Bags for Women
|Вид оплаты:
|T/T,Paypal,Money Gram,Western Union
|Количество минимального заказа:
|100 Piece/Pieces
|Срок поставки:
|15 дней
Базовая информация
Модель: DKB-4026-F0052
Пол: унисекс
материал: Полиэстер
Применение: Студент, Кемпинг и путешествия, Виды спорта
Стиль: Досуг
Вместимость: Мини
Время года: Все
Подходит для: путешествующий
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цвет: Смешанный цвет
Application: Travel, Sport, Leisure & Promotion Etc.
Feature: Eco-friendly,high Quality,washable,recyclable
Custom: Small Order Accept
Closure Type: Zipper
Interior & Outside Structure: Front Pocket And Zipper Pocket
Delivery Time: 12~16 Work Days For Normal Item
Material: Polyester + Fabric Lining
Function: Gym Bags / Travelling Bag
MOQ: 100pcs Per Item
Colors: Red,purple & Orange
Payment Term: Paypal,T/T Or Western Union
Rough Size: 40 X 26cm (L * W * H)
Straps: Adjustable And Detachable
Additional Info
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производительность: 10000 per day
марка: He-kayla & Jex
транспорт: Ocean,Land,Air
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Порт: Shenzhen,Guangzhou,Hong Kong
Описание продукта
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Fiat CEO Sergio Marchionne has threatened to move planned production of upcoming Alfa Romeo models out of Italy, in his usual blunt way, expressing frustration at work laws and legal wrangling after an court ruled that portions of the country's labour laws were unconstitutional.
"The relaunch of Alfa Romeo will continue for sure," Marchionne told Bloomberg recently in Turin. "Italy should decide if they want it to happen here or not, as Fiat and Chrysler have several alternatives."
Marchionne and Fiat have put planned investments into its Italian plants on hold after the decision came down in early July, while Marchionne lobbies Prime Minister Enrico Letta's government to adopt reforms that help manufacturers with clearer work rules.
The report said Fiat is planning to develop and produce eight Alfa Romeo models and six Maserati models in Italy, supported by investments of more than €2-billion ($2.7-billion) in Italian factories that are under-utilized.
The Alfa Romeo product renaissance will start later this year, when the two-seat 4C will be launched in Europe, a mid-engine Porsche Boxster competitor that has been lauded for its beauty at various auto shows, and made its dynamic debut at the Goodwood Festival of Speed this past weekend.
Production plans for both the lightweight 4C two-seater and Maserati Ghibli mid-size sport sedan are both confirmed to start later this year in Italy, but the ruling and Fiat declaration place the future of 11 models by the two upscale Fiat brands into question. The Maserati Levante SUV and the Alfa Romeo Giulia sedan are scheduled to start production in Italy by 2016, but Marchionne said "clear and reliable rules" are needed first.
Marchionne may be able to update Canadian reporters in mid-February on Alfa Romeo's production plans as well as when the brand will be available in Canada, as he will be the keynote speaker at the opening of the 2014 Canadian International Auto Show in Toronto. In the United States, the Alfa Romeo 4C will reportedly be sold out of Fiat dealerships, with company reps confirming that Alfa will eventually sell mid-size and full-size sedans in North America.
Consumer Reports tests effect of speed on fuel use
Even using relatively fuel-efficient four-cylinder models, the difference between conservative driving and "keeping up with traffic" could be as high as 32 per cent, Consumer Reports testing has found.
A recent test by the magazine examined a four-cylinder Honda Accord, Toyota RAV4 and three versions of the Ford Fusion at three different speeds – 55 mph (88 km/h), 65 mph (105 km/h) and 75 mph (121 km/h) – to calculate how much extra fuel was burned the faster a vehicle travels.
The increases in fuel consumption ranged from 27 per cent (in the Fusion Hybrid, Fusion 1.6 and RAV4) to 32 per cent in the Fusion Titanium with the 2.0-litre turbocharged engine. The Accord LX saw an increase of 29 per cent.
The Fusion 2.0 that saw the largest discrepancy achieved 41 miles per gallon (5.7 litres/100 km) at a snail-like 55 mph, or just under its Canadian highway fuel consumption rating of 5.9. But at closer to 75 mph, the efficiency dropped to 28 mpg, or 8.4 L/100 km. On a 322-km journey, this will cost you about 7-1/2 litres of extra fuel, or approximately $9.75 if you're paying $1.30/litre for fuel.
Good to keep in mind when setting the cruise on those long summer road trips.
Also interesting to note that a regular internal combustion engine in the Fusion provided the largest observed difference in fuel economy; Ford has faced lawsuits in the United States in the past year for deceptive marketing for overly optimistic Fusion Hybrid and C-Max Hybrid fuel consumption figures.
Rally highlights EV versatility
A Canadian couple in a Tesla Model S, Randy and Cheryl Taylor, were the only Canadians participating in the BC2BC, a long-distance, pure electric car rally. The couple also scored a meeting with Tesla chief executive Elon Musk and JB Straubel, the company's chief technical officer, who signed their car.
The rally ran from the British Columbia border to Baja, Calif. – thus the BC2BC 2013 moniker – starting on June 29 and ending on July 7, and included various Teslas, Leafs, a Toyota RAV4 EV, Mitsubishi i-MiEV and a long-distance modified Zero motorcycle.
The annual rally, meant to highlight that pure electric vehicles could easily cover long distances with the right fast-charging facilities in place, comes at a time of growing investment in such facilities, at least in the United States.
Along with Tesla's Supercharger network, which is scheduled to include expansion into Canada by the end of the year, Nissan announced last week that it plans to add 100 DC quick chargers at dealers across the United States by April 1, 2014, to add to the 24 west coast Nissan dealers that already offer the quick chargers, which can provide an 80 per cent charge in about 30 minutes from empty.
These DC quick chargers are seen as prime motivators for Leaf sales by Nissan in the United States as it allows for easier long-distance driving than the more common Level II chargers that are popping up all over the country, but which still require hours for a full charge of any battery electric vehicle. Unfortunately, no similar plans have been announced by Nissan Canada, but with every such announcement by Nissan USA – and there have been several – the corporate silence on this side of the border becomes increasingly deafening.
This could be a good question to put to Nissan reps at the EV Day gathering planned at Yonge and Dundas Square in downtown Toronto on July 18. From 9 a.m. to 8 p.m., Toronto's version of Times Square will host displays on the differences and environmental and cost benefits of plugging in for fuel.
Eight plug-in cars will be available for test drives, including three from Ford (Fusion and C-Max Energi, and Focus Electric), the Toyota Prius Plug-In, Chevrolet Volt, Leaf, Mitsubishi i-MiEV and Smart fortwo Electric Drive.


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Sadly, some rescued horses and ponies who arrive here have endured the most terrible trauma and from Aura's behaviour we knew that she had suffered more than most. The 12hh Appaloosa mare was found alone on Dartmoor, seriously underweight, very poorly and horribly stressed.
In fact, Aura remained so terrified she lost almost all her coat and stood at the back of her stable with her head against the wall fearful of being approached. It was almost impossible to get near her and it took the grooms a long time to gain enough trust for her to want to spend any time with humans.


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4 Destinations for a Refreshing Memorial Day Weekend Getaway
Sunshine & Family Time
Memorial Day is a US holiday, observed on the last Monday in May. It honors the men and women who gave their lives while serving in the American military.
Cities and towns across the USA host Memorial Day parades every year. It's a public holiday and a day-off for the general population which means most businesses and schools are closed.
Memorial Day weekend also unofficially marks the end of the long winter and the arrival of spring. Many people celebrate this public holiday by visiting memorials, participating in parades or taking family road trips.
When it's time to bring the flip flops and lawn chairs out of the garage and start preparing for a getaway, where should you head? The following places to go Memorial Day weekend are sure to inspire you.
Austin, Texas
Austin is delightfully weird and wonderful. It's known for its excellent live music scene, delicious food and funky hipster neighborhoods alive with cafes, bars and restaurants. Taking a walking tour of downtown from the Austin Visitor Center is a great way to get your bearings and learn about the history of the city.
If the sun is shining, you can go for a bike ride along the 10-mile-long Ann and Roy Butler Hike and Bike Trail around Lady Bird Lake. The views of the sparkling waters and the Austin skyline are spectacular. Or, you can cool off in the swimming hole at Pedernales Falls State Park, located just west of Austin.
At sunset, head to the bridge on Congress Avenue. When twilight falls, you can see the incredible natural spectacle of 1.5 million bats swooping through the sky.
Photo Credit: Getty Images
Vail, Colorado
Although the skiing season is over, Vail is still a fantastic place to head for a weekend away. There will be a lot of events happening in this mountain town at this time of year, such as the Blues, Brews & BBQ Festival.
There are plenty of things to do in Vail besides hit the slopes. You can go shopping in the stylish boutiques and gift shops of Vail Village, hit the spa, or go for a walk through Betty Ford Alpine Gardens. If you are up for it, the Booth Falls Trail is a challenging hike that will take you through alpine meadows and thick spruce forest to a sparkling mountain lake.
It's a great time to dine in Vail as well. During this time of year, many of the restaurants will be offering "End-of-Season Dining Deals."
Planning a trip to the Netherlands? Check out our list of what not to miss in Amsterdam so you experience the best that the city has to offer!
Photo Credit: Getty Images
Charleston, South Carolina
This beautiful historic town has a laid-back vibe and is a great option for a Memorial Day getaway. You can stroll along the cobblestone streets and admire the facades of the pastel-hued pre-Civil War homes.
Take a walk downtown to Marion Square, the central square of the city. During Memorial Day weekend there will be family-friendly events including dancing, arts and crafts, and live music.
If you are blessed in the facial hair department, you could compete in the Annual Southeastern Beard and Moustache Championships at the Music Farm on Memorial Day weekend. Proceeds from the event go to the Big Brothers & Big Sisters of Carolina Youth Development Center.
Photo Credit: Getty Images
Lake Tahoe, California
If you love the great outdoors, the natural beauty of Lake Tahoe will call to you on Memorial Day weekend. This is a great weekend for cyclists and mountain bikers, as many mountain bike trails will be opening for the season. It's also a perfect time to hike as the weather will be warm but not too hot.
Another great way to enjoy the lake is to rent a paddleboard or kayak and explore the 72 miles of shoreline at your own pace. Be sure to visit Sand Harbor, one of the best beaches on the lake.
Even the Heavenly Mountain Gondola opens exclusively for Memorial Day weekend before it opens for its full summer schedule a few weeks later. Also, the Made in Tahoe Festival will be taking place on Memorial Day weekend. It's a showcase of local products made by Tahoe artisans and chefs. There will also be music, live entertainment and more.
These are just a few of the best Memorial Day vacations where you can get away on this beautiful spring weekend. Remember to book your accommodation as far in advance as possible, as this will be a very popular travel weekend.
Where will you go this year?


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Chang Hsing-lang was born in Sze-Yang, Kiangsu, China in 1887.
author and university professor
Chang Hsing-lang was born in Sze-Yang, Kiangsu, China in 1887.
Mr. Chang attended native private schools before 12 years of age. He went to Wusih and Soochow to study Chinese literature under a certain scholar in 1898. In 1899 he entered the middle school of Nanyang College, Siccawei, Shanghai. Mr. Chang entered Peiyang University, Tientsin, to study mining engineering in 1903. Then he went to U.S.A., studied chemistry in Harvard University 1906, graduating with Bachelor of Science degree from Harvard in 1909. From 1909 to 1912 he took chemical research work in Berlin University, Germany.
Chang Hsing-lang returned to China in 1912. He served as technical expert in the civil government of Nanking in 1913. Between 1914 and 1917 he was a professor of chemistry in Peking Government University. From 1917 to 1918 he worked as a special correspondent to the Chinese National History Compiling Bureau resident in Japan.
From 1918 till 1923, most of the time Chang Hsing-lang devoted to the compilation of the "Materials for a History of the Intercourse between China and the Western Countries," and preparation for a Chinese edition of the "Travels of Ser Marco Polo" based upon Yule's English work. In the period from 1925 to 1926 he was a chemist on the Tsingtao and Tsinan Railway.
Between 1926 and 1927 Mr. Chang worked as a Dean of the Sinological Institute of Amoy University, since 1927 - professor of history in the Catholic University of Peking, secretary of the Chinese Geographical Society, Peking.


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How following Warren Buffett could help you prosper in a recession
It's all doom and gloom these days, with the FTSE 100 falling along with all the world's other major indexes. And investors the world over are fretting over what'll happen next week.
I reckon the surest way to calm troubled waters is to ask "What would Warren Buffett do?" I'm sure he's not worried in the slightest by the prospect of even a few years of weak markets. On the contrary, I expect he's salivating over the possibility of picking up some bargain shares.
Buffett famously said that if you're not comfortable owning a stock for 10 years, you shouldn't own it for 10 minutes. But doesn't he adjust that when there are signs of a market meltdown coming? No, that would be missing the point, which is that you should only buy a stock if you'd be happy holding it for a decade… whatever the market or the economy might do over that period.
Looking at a risky company that should be fine in good times, but which might struggle in a downturn? According to Buffett's rule, that's one you should never buy, not even when the economy is healthy and all is fine with the world.
Couldn't you sell the moment things start to look a bit shaky? Buffett also said: "Only buy something that you'd be perfectly happy to hold if the market shut down for 10 years." So no, treat each purchase as if the market's going to close for a decade the day after you buy it, making it impossible for you to sell in the mean time.
That should focus your mind on investing only in companies that are so good they'll shine over the long term, regardless of short-term ups and downs.
Good price
Buffett's "It's far better to buy a wonderful company at a fair price than a fair company at a wonderful price" rule comes to the fore here. Truly wonderful companies have defensive qualities that protect them when times are hard. All you really need to do is buy them when the price is enough to provide an adequate safety margin.
What should you do when we're actually in a recession and markets are down? If you don't have extra cash to invest, you could just switch off the market. By that, I mean forget share prices, don't even look at them, and don't come back until the recession is over (or when the current crisis, whatever it is, has ended). That would take steely nerves, mind, but Warren Buffett certainly has those.
Benefit from fear
If you do have more cash to invest, you should be rubbing your hands with glee — and planning to follow Buffett's "Be fearful when others are greedy and greedy when others are fearful" rule. When all the so-called experts are weeping and wailing and selling their fallen shares because they're too afraid of what might happen tomorrow, or next week, that's the time to help yourselves by taking them off their hands at a bargain price.
It's what I'm planning to do. I have a significant sum in my SIPP, recently liberated from a managed company pension fund, just waiting for me to buy great shares at depressed prices. Recession? Bring it on.
5G is here – and shares of this 'sleeping giant' could be a great way for you to potentially profit!
According to one leading industry firm, the 5G boom could create a global industry worth US $12.3 TRILLION out of thin air…
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It's just ONE innovation from a little-known US company that has quietly spent years preparing for this exact moment…
But you need to get in before the crowd catches onto this 'sleeping giant'.
Views expressed in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.


text: If taking photos is one's forte, Sapa is the gem for spectacular vistas of rolling peaks and plunging valleys. Trekking with local hilltribes and experiencing the local culture of the "Mountain people". Once a hill station for the French armed forces, experience today's rural life by passing through small villages and rice-terraced valleys. Sapa is now one of the main highlights in traveling to Vietnam.


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Washington, D.C. 20549
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):
(Exact name of registrant as specified in its charter)
(State or other jurisdiction
of incorporation)
(Commission File Number)
(IRS Employer Identification No.)
(Address of principal executive offices)
(Zip Code)
(Registrant's telephone number,
including area code)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
Securities registered pursuant to Section 12(b) of the Act:
|Title of each class
|Name of each exchange on which registered
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨
Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant.
As previously disclosed, in October 2017, Tailored Brands, Inc. (the "Company") amended its asset-based revolving credit agreement (the "ABL Facility"), the material terms of which are described in Note 6 to the consolidated financial statements included in the Company's most recent Annual Report on Form 10-K for the fiscal year ended February 2, 2019 filed with the Securities and Exchange Commission on March 29, 2019, and incorporated by reference herein.
As of February 1, 2020, $50.0 million of borrowings were outstanding under the ABL Facility and letters of credit totaling approximately $26.6 million were also issued and outstanding. On March 16, 2020, the Company notified JPMorgan Chase Bank, N.A., as administrative agent under the ABL Facility, to draw $260.0 million under the ABL Facility. In addition, after assessing the Company's remaining availability under the ABL Facility and determining that an additional borrowing was prudent to maximize cash on hand, on March 19, 2020, the Company borrowed an additional $25.0 million under the ABL Facility. The Company notes these borrowings under the ABL Facility are proactive measures in order to increase its cash position and preserve financial flexibility in light of current uncertainty in the global markets resulting from the coronavirus outbreak. The ABL Facility matures on October 25, 2022.
As of March 19, 2020, total borrowings outstanding under the ABL Facility were $360.0 million and letters of credit totaling approximately $26.5 million were also issued and outstanding. As of March 19, 2020, the current interest rate for borrowings under the ABL Facility is approximately 2.2%.
Item 8.01 Other Events.
On March 17, 2020, the Company issued a press release announcing that in response to the coronavirus and to protect the health and safety of its customers, employees and the communities in which it serves, the Company will temporarily close its retail locations in the U.S. and Canada starting Tuesday, March 17, 2020 through Saturday, March 28, 2020.
On March 19, 2020, the Company issued a press release announcing that in light of evolving government and citizen response to the coronavirus outbreak, it will, out of an abundance of caution and concern for its employees, close its e-commerce fulfillment centers starting Friday, March 20, 2020 through at least Saturday, March 28, 2020, and will suspend the currently limited operations in its retail stores during this period.
The Company will determine, based on the facts available at the time, whether it is appropriate to reopen its stores and e-commerce fulfillment centers at that time or extend the closure date.
This Current Report on Form 8-K contains forward-looking information, including the Company's statements concerning the coronavirus and preserving financial flexibility in light of current uncertainty. In addition, words such as "expects," "anticipates," "envisions," "targets," "goals," "projects," "intends," "plans," "believes," "seeks," "estimates," "guidance," "may," "projections," and "business outlook," variations of such words and similar expressions are intended to identify such forward-looking statements. The forward-looking statements are made pursuant to the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995. Any forward-looking statements that we make herein are not guarantees of future performance and actual results may differ materially from those in such forward-looking statements as a result of various factors. Factors that might cause or contribute to such differences include, but are not limited to: actions or inactions by governmental entities; domestic and international macro-economic conditions; inflation or deflation; the loss of, or changes in, key employees; success, or lack thereof, in formulating or executing our internal strategies and operating plans including new store and new market expansion plans; cost reduction initiatives and revenue enhancement strategies; changes to our capital allocation policy; changes in demand for our retail clothing or rental products; market trends in the retail or rental business; customer confidence and spending patterns; changes in traffic trends in our stores; customer acceptance of our merchandise strategies, including custom clothing; performance issues with key suppliers; disruptions in our supply chain; severe weather; public health crises, including the recent coronavirus outbreak; foreign currency fluctuations; government export and import policies, including the enactment of duties or tariffs; advertising or marketing activities of competitors; the impact of cybersecurity threats or data breaches; legal proceedings and the impact of climate change.
Forward-looking statements are intended to convey the Company's expectations about the future, and speak only as of the date they are made. We undertake no obligation to publicly update or revise any forward-looking statements that may be made from time to time, whether as a result of new information, future developments or otherwise, except as required by applicable law. However, any further disclosures made on related subjects in our subsequent reports on Forms 10-K, 10-Q and 8-K should be consulted. This discussion is provided as permitted by the Private Securities Litigation Reform Act of 1995, and all written or oral forward-looking statements that are made by or attributable to us are expressly qualified in their entirety by the cautionary statements contained or referenced in this section.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits. The following exhibits are included in this Form 8-K:
|Press Release of the Company dated March 17, 2020.
|Press Release of the Company dated March 19, 2020.
|Cover Page Interactive Data File (the cover page XBRL tags are embedded in the Inline XBRL document).
|Press Release of the Company dated March 17, 2020.
|Press Release of the Company dated March 19, 2020.
|Cover Page Interactive Data File (the cover page XBRL tags are embedded in the Inline XBRL document).
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Date: March 19, 2020
|/s/ Brian T. Vaclavik
|Senior Vice President and Chief Accounting Officer


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