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Sometimes it is All in the Genes
Part I--"The Genetic Test"
by Anne Galbraith and David Howard* Department of Biology University of Wisconsin--La Crosse
"Your pregnancy seems to be progressing just fine, but we'll do some blood work to be on the safe side. As long as we're drawing blood from you today, Nancy, would you consent to participate in one of the genetics studies we're conducting here at People's Best Hospital?" Dr. Kwin prided herself on putting her patients at ease, but her question caught Nancy a little off guard. "What would that entail, Dr. Kwin?" While Nancy believed Dr. Kwin wouldn't ask her to do anything that wasn't a good idea, she never said yes to anything until she had all the information. Dr. Kwin began to explain, "Well, as you know, PBH is a research and teaching hospital. One research team is trying to determine the frequency of the gene for the genetic disorder cystic fibrosis in the U.S. population. And since you are having blood drawn anyway as you enter your second trimester...." Genetic disorder? Cystic fibrosis? The phrases made Nancy feel panicky. She interrupted Dr. Kwin mid-sentence. "You don't think I have that disease, do you? Isn't cystic fibrosis serious? How could I have caught it?" The questions came out in a rush. Hearing the anxiety in Nancy's voice, Dr. Kwin quickly reassured her. "No, no. I'm quite sure that you do not have cystic fibrosis. You can't 'catch' it; you can only inherit it. If you did have cystic fibrosis, you would have been diagnosed when you were a toddler. You have absolutely nothing to worry about. However, let me emphasize that if you feel uncomfortable about participating in this study in any way, just say 'No.' My feelings won't be hurt. There is no pressure to participate." "If it's inherited and I don't have it, why would they want to test me?" The situation still didn't make sense to Nancy. "First, let me explain some basics. Cystic fibrosis, or CF, is a disease that is caused by defects in a particular gene. Actually because CF is genetic, 'disorder' is a better term than 'disease.' The word disease should really be used for illnesses caused by bacterial or viral infection. However, people use both words for CF. "The reason that they need to include people who don't have CF in the study is that cystic fibrosis is a recessive disorder. With a recessive disorder, a person has to have two defective versions of the CF gene to have CF. Therefore you can be a carrier of one defective version but not have CF at all. It is precisely that which has inspired the study. They want to know what percentage of people in the United States carries one defective gene for cystic fibrosis. That percentage is called the gene frequency and can provide a lot of information for people working on CF."
Dr. Kwin went on to explain, "CF is one of the most common genetic disorders among Americans of European descent. Although it has many symptoms, the worst are severe respiratory problems that typically lead to death around the age of 30. One of the first reliable tests for any genetic disorder was the one developed for CF in 1990. Because CF is one of the first inherited illnesses that researchers have been able to get a handle on, these sorts of genetic screenings are pioneering work not only for CF research but also for understanding other genetic ailments." Nancy considered the flood of information for a few seconds. "I can't see what harm it would do. You run so many tests on me anyway. What's one more?" "I'll have one of the staff bring you the consent forms and explain the procedure to you further. If you do consent, your biggest decision will be whether or not you want to have the results reported to you. You need to think carefully about that question before signing the consent form." As Dr. Kwin left the room, Nancy thought to herself, what are the pros and cons of knowing the results?
1. Discuss why Nancy might or might not want to know the results of her blood test for CF. 2. Dr. Kwin told Nancy that she has "absolutely nothing to worry about." Although Nancy cannot get CF, is Dr. Kwin's statement entirely correct? 3. Did Dr. Kwin provide Nancy with enough information about cystic fibrosis and the test to make a good decision? 4. Should Nancy consent to the test? Provide the reasoning for your answer.
*Note: Both authors contributed equally to this case and its teaching notes.
Sometimes it is All in the Genes
Part II--"Sharing the Bad News"
by Anne Galbraith and David Howard Department of Biology University of Wisconsin--La Crosse Nancy had found it hard to concentrate at work that afternoon and it was almost impossible to think about what she was doing as she prepared dinner that evening with her husband Jake. Suddenly Jake's voice snapped her back to the kitchen, "Nancy, you're about to put the carrots and cucumbers in the garbage." Jake surveyed the salad bowl where she had been working and smiled at the rare opportunity of catching his wife in a mistake. "And is vegetable peel salad your latest craving?" "Oh, honey, I need to talk to you about something." The stress in Nancy's voice quickly wiped the smile off of Jake's face. "Remember when I went for my pre-natal checkup a couple of weeks ago, and I told you I was participating in a genetic study?" "Yeah, something about MS or something, right?" "No, CF, cystic fibrosis." Nancy corrected him. "Well, it turns out that I tested positive." "What!? How did this happen? You don't seem sick at all." In response to his panic, Nancy calmed down and explained, "No, no, of course I'm not sick. Remember, I told you that they were testing to see if I was a genetic carrier. How it happened was that I inherited one bad version of the gene, a bad 'allele' they call it, for cystic fibrosis from one of my parents." He felt he should know why, but slowly Jake asked, "If you don't have CF, what makes you so worried that you're throwing sliced cucumbers into the garbage?" "Because there is a chance that I could pass my bad CF allele to our child. And if you are a carrier and pass on your CF allele, then she or he will have CF." "CF is pretty serious, right?" "Yes, pretty serious." Trying to be optimistic, Jake asked, "Yeah, but what's the chance that I'm a carrier too?" "Dr. Kwin says the latest research indicates 1 in 29," Nancy answered soberly. Jake's jaw dropped. "Can I get tested? What is the likelihood that you'll pass on the CF gene? What is the chance that I'll pass on the gene? What is the chance our baby will have CF?"
"Yes you can, and will get tested. I don't care if you are afraid of needles." Nancy left no room for further questions there. "I talked to Dr. Kwin at length today and I have a pretty good handle on this genetics thing. So, turn down the stove, sit down with me, and I'll answer your questions." "Let's start with the basics," Nancy began. "We all have tens of thousands of different genes in each of the cells in our body. These genes provide the instructions on how to make all the components of our body. For almost all of those genes, we have two copies of each different gene. I inherited one copy of the gene that can cause CF from my mother and one from my father. One of them, I don't know which, was a defective copy, what they call a 'mutant' allele. One of the alleles I got from my parents was a normal, working copy. Because CF is what they call 'recessive,' I'm fine because I have that one good copy. It takes two bad copies of the gene to give you cystic fibrosis."
Help Nancy finish answering Jake's questions. 1. The normal or good copy of the CF gene can be written shorthand as "F", and the mutant or bad copy of the CF gene can be represented as "f". Using this shorthand style, write out Nancy's genetic make-up for this gene. 2. What is the chance that Nancy passed on the CF allele to her baby? 3. What is the chance that Jake passed on the allele if he is a carrier? 4. What is the chance that their baby will have CF if they are both carriers? If their first child has CF, what is the chance that their second child will have CF? What is the chance that the baby will inherit CF if only Nancy is a carrier?
Sometimes it is All in the Genes
Part III--"The Decisions Become Tougher"
by Anne Galbraith and David Howard Department of Biology University of Wisconsin--La Crosse Jake gripped Nancy's hand as they sat in the office waiting for the genetic counselor. When Jake tested positive as a CF carrier, Dr. Kwin had set up an appointment with the counselor for the next day. What had first seemed like a helpful thing to do for science had suddenly developed into a problem that Dr. Kwin did not feel qualified to handle. Just being in a specialist's office made the couple nervous. They both jumped a little when the door opened. "Hello. I'm Dr. Joon Park." The counselor shook hands with them as he continued. "I understand that you both tested positive as carriers for cystic fibrosis, but neither of you had any family history of the disease." "Yes," said Nancy. "That's one of the questions that bothers me. How could we both be carriers yet we don't even know anyone with cystic fibrosis?" "Good question," Dr. Park replied reassuringly. "On the surface that might seem unusual, but it is actually quite common with recessive genetic disorders. In fact, around 80 percent of children born with cystic fibrosis are born to parents with no family history of the disease." Dr. Park paused, then continued. "I'm glad that you are already comfortable asking questions. One part of my job is to answer any questions you might have about inherited diseases and CF in particular. The other goal for us today is to discuss your current options." Jake entered the conversation. "Yeah. What are our options? I want to know if our baby is going to have cystic fibrosis, but we can't just do a blood test now. Can we?" "No. You are right. We can't do a blood test." Before Dr. Park could finish, Nancy jumped in to add, "But we can do a genetic test through amniocentesis, can't we?" She looked at Jake with an expression that told him he should have read the pre-natal baby books as she had asked him to do. "Yes, Nancy, we can do amniocentesis." Dr. Park went on to explain for Jake's benefit. "Using ultrasound to guide them, doctors insert a small needle through the abdomen and into the uterus. A small amount of the amniotic fluid that surrounds the fetus is removed. Fetal cells that have sloughed off are found in that fluid and from those cells, DNA can be isolated and checked for the presence of two bad copies of the gene that cause cystic fibrosis." "What are we waiting for?" an anxious Jake questioned. "Let's get the test done." "There is a chance that the amniocentesis will cause a miscarriage. However, here at People's Best Hospital, miscarriage occurs less than 0.5 percent of the time."
"Point five percent; that still amounts to 1 in 200." Jake did not lack intelligence, he just thought he would have another four and a half months before he really had to worry about anything related to babies. Nancy interrupted. "Dr. Park, what exactly causes cystic fibrosis? What sort of life do people with CF lead?" "Cystic fibrosis is caused by a mutation in a gene called CFTR. A normal CFTR gene carries the instructions to make a protein that allows chloride to pass out of a cell. When chloride moves, it causes water to follow and secretions are formed outside the cells. When a person has cystic fibrosis, both alleles of their CFTR gene are mutated. The mutant genes create defective CFTR proteins or no CFTR protein at all. The lack of a functional CFTR protein means that not enough chloride moves out of the cells, in turn causing less water to move. The reduced water content causes the secretions to be thicker than normal. This thick, sticky mucus usually has its worst effects on the lungs and the pancreas. "Normally, a thin layer of mucus coats the bronchioles and bronchial tubes in our lungs. This mucus traps dirt and germs and continually travels to the throat. Thus, the mucus removes the bad stuff from our lungs. In CF patients, the thicker mucus in the lungs can't be moved out as easily. This accumulation of mucus can block the air passageways. Worse yet, it allows bacteria to get trapped in the lungs where they can cause debilitating infections. While most of the symptoms of CF can be treated pretty effectively now, the continual stress and recurring infections in the lungs means that patients today still die in their 30s or earlier." "If our baby tests positive for cystic fibrosis, what sort of treatments can we do before she is born?" Although a boy would be a joy, Nancy really wanted a girl. "Unfortunately, there is nothing that we can do to help her before birth. Currently, we can only treat the symptoms, and she won't have symptoms until after she is born." As long as he had been at his job, Dr. Park hated being the bearer of bad news. However, he felt that the simple truth was the best approach. "Of course, there are many promising new technologies that are being investigated to treat CF. Still, even the most promising of those would not help before she is born." Inwardly, Dr. Park cursed the technologies for not delivering yet what they promised. There was a long silence. Finally, Jake decided to find out what his wife was thinking. "I think I'd still like to know if our baby has CF or not. But I'm not sure about the risk. What do you think, honey?"
1. 2. 3. 4. How do mutant CFTR genes lead to thicker mucus in cystic fibrosis patients? How would testing their unborn baby for CF help Nancy and Jake? Their baby? What are their options if they find out their baby does have two bad CFTR genes? Should they have the amniocentesis procedure? Provide your reasons for reaching this decision.
Sometimes it is All in the Genes
Part IV--"A New Hope or a False Hope?"
by Anne Galbraith and David Howard Department of Biology University of Wisconsin--La Crosse As Nancy used her cupped hands to pound on her son's back, she reflected on what her family had been through in the seven years since she had volunteered for the genetic screening research. Joshua was a wonderful, loving son. She wouldn't trade a minute with Joshua for anything in the world, but motherhood was not quite what she had envisioned in her dreams. Raising a child with CF was tough, no way around it. Joshua was lying on an incline with his head below his chest. The angle and the vigorous chest percussion helped the mucus to move out of his lungs. As a newborn, his first symptom of CF was overly salty sweat. This is actually the most common diagnostic test for CF. During his first months of life, Joshua didn't eat well and he had numerous loose bowel movements. Since then, part of his daily regimen included supplements of digestive enzymes that substituted for those that his poorly functioning pancreas couldn't supply. Fat-soluble vitamins helped him gain weight. I'll never have to buy clothes in "husky." Nancy thought to herself. But at least Joshua is now on the pediatrician's growth curves. Just as the doctors had predicted, the biggest problem was with Joshua's lungs. He was almost always on antibiotics. These were usually taken by breathing in a medicated vapor from a nebulizer. The medicated vapor also helped to open up the mucus-clogged airways. However, hospital stays for intravenous antibiotics and "pulmonary clean-outs" were not uncommon. So far, Joshua was doing well in school, but Nancy was concerned about the number of days he had to miss. In fact, she would have to take him out of school early tomorrow to make their appointment at the pediatrician's office. "Well, Joshua, it looks like you are doing great. How is school? Any more home runs in kickball?" Although her extensive training meant that Dr. Julia Bryant had some of the sickest patients in town, her bedside manner meant that her little friends still liked to visit her. "Yes!" Joshua responded enthusiastically. "I had one on Monday. A grand slam!" "Wow! I wish I could have seen it. Do you want to get down and play a little while I talk with your mother?" "Sure, Dr. Julia." For once, Julia's demeanor didn't lose any of its cheerfulness as she turned to Nancy. "Joshua really is doing well. You and Jake do such a good job with the home therapy." Julia glanced over to see that Joshua was starting a jigsaw puzzle. "You know how I had warned you off of gene therapy a couple of years ago when you asked me about it?" Nancy nodded in agreement. "There is a new cystic fibrosis gene therapy clinical trial over at People's Best. They have asked us here at Children's Coolest Clinic for volunteers. I'm not telling you to run out and get involved, but I do think that it's time to carefully consider it."
Experience had taught Nancy not to get too optimistic, but her pulse began to race nonetheless. "Why should we consider it now?" "I'm sure you remember that the first patient treated with gene therapy was a four-year-old girl back in the early 90s. She had an inherited form of severe combined immunodeficiency, also known as the 'boyin-the-bubble syndrome' or SCID. Because the treatment was such a success, many people jumped on the gene therapy bandwagon. Unfortunately, after those initial successes, gene therapy has not produced the hoped-for results." Nancy did remember that and more. "Didn't someone even die from gene therapy treatments?" "Yes, in the fall of 1999 an 18-year-old man died from his gene therapy treatments. Doctors were trying to correct his inherited enzyme deficiency. That case is why I think we should be very cautious before we decide whether or not to get Joshua involved." "First you don't think it's worthwhile. Then someone dies, and now it's a good idea? What aren't you telling me, Julia?" "Well, in the spring of 2000, there were reports of two more successes with gene therapy. The two patients also had the boy-in-the-bubble syndrome, not CF. However, their illness was caused by a mutation in a different gene than the first successful patients, meaning that gene therapy can work with other genes." "That is encouraging, but what actually killed the young man who died? Was the gene poisonous?" Nancy was still focused on that death. "No, the gene wasn't 'poisonous'. The death had nothing to do with the gene itself but how the gene was delivered. As you know, a gene is simply a stretch of DNA in the chromosomes of your cells. In a recessive, inherited disease, the DNA in both copies of the gene, like the CFTR gene in Joshua's case, has errors in its code. The goal of gene therapy is to get an error-free copy of the gene back into the patient's cells. The new, good copy can then do the job for the patient's own bad ones. "The trick is in inserting the good DNA into the patient's cells so that the gene is used by those cells. The most heavily studied and commonly used means for this DNA delivery is using viruses. One of those viruses is called adenovirus, which is one of the causes of the common cold. Part of the virus's natural life cycle is to get its DNA inside human cells and have its genes used by the human cells. To use adenovirus for gene therapy, researchers take the genes that cause illness out of the viral DNA and replace them with the human gene that the patient needs. Unfortunately, the virus still causes the patient's immune system to respond and it tries to fight off the infection. In the case of the man who died, doctors gave him a dose of adenovirus that was too high. The virus escaped the target organ, the liver, and infected tissues throughout his body. This caused an immune reaction that led to inflammation throughout his body. His temperature shot up to 104.5º F, and he was in a coma on the second day. Eventually, his lungs began to fill with fluid, so much so that he soon died." "Why did the doctors give him too much virus?" "They had no way of knowing it would be too much. The previous work at lower doses suggested the higher level would be safe. However, they apparently passed a critical threshold that no one could foresee."
"How do we know there won't be the same sort of hidden threshold in these CF gene therapy trials?" "Until you and I find out more information about the specific clinical trials at People's Best, we don't. Even then we probably won't be 100 percent sure. Clinical trials are research, you know." "Yes, but if Joshua could be helped...." Nancy's voice trailed off momentarily. "Besides the new boyin-the-bubble success, what makes you think gene therapy might work now?" "Well, different kinds of viruses that get the gene into cells by different means are being developed. In addition, researchers are experimenting with using liposomes or fat droplets to deliver the gene to the target cells. That would eliminate the risk posed by viruses. I know that both of these approaches are being tested in clinical trials for CF, but I don't know yet which will be conducted here in town." Julia felt guilty for not knowing more, but she had just heard about the program at People's Best and wanted to get Joshua in as early as possible. "Liposomes? That sounds like skin cream stuff." "It is basically the same approach. Just a little more sophisticated for gene therapy." Julia brought the topic to a close for the day. "If you are interested in finding out more, I'll set up an appointment for both of us with one of the leaders of the study. We'll tag-team them with questions." "Of course I want to find out more. Boy, am I going to have a long discussion with Jake tonight!"
1. The current therapies available to treat CF only treat the symptoms of the disorder. However, if gene therapy were to work, it could be considered a cure rather than a mere treatment of the symptoms. Explain why this could be the case. 2. "The successful use of gene therapy to cure SCID syndrome (2000) is hoped to be a permanent cure for those patients because a good copy of the problem gene was inserted into the patients' blood stem cells in the bone marrow (hematopoietic stem cells). Once white blood cells enter the blood stream they have a limited life span, on the order of a few week to months. The blood stem cells are the cells that create more white blood cells to replace those that are lost. If the gene was only inserted into the circulating mature white blood cells, the patient would only be temporarily cured until those cells were used up or died." The current gene therapy approaches to cure CF involve inserting a functional CFTR gene into the mature epithelial cells of the lungs. In light of the preceding paragraph, do you think that this approach would be a "permanent" cure for CF? Explain your answer. 3. What level of risk should be acceptable for a patient involved in a clinical trial? In other words, under what circumstances should Nancy feel comfortable enrolling Joshua in a gene therapy clinical trial? 4. In the current clinical trials for gene therapy treatments of CF, participants must be over 12, so Joshua could not be helped by the trials that are currently being run at this time. Why might there be an age restriction such as this? Is an age restriction such as this fair? 5. Should Joshua be enrolled in a clinical trial on cystic fibrosis gene therapy?
Date Posted: 09/24/02 nas Copyright © 2003 by the National Center for Case Study Teaching in Science. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.
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The antihero of Sebastian Faulks's new novel is a pub-crawling, aesthetically The narrator, Mike Engleby, begins his long apologia with an. Narrated in the first person by the main character, Mike Engleby, Faulks's seventh novel is modern, demotic and funny – albeit in a deep shade of black. It's hard. Engleby has ratings and reviews. Jeff said: Bestselling British author Sebastian Faulks reinvents the unreliable narrator with his singular, haunting.
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Mike Engleby is a chilling and unforgettable character, and Engleby is a novel that will surprise and beguile Sebastian Faulks' readership.
Certainly, it's hard to imagine being like Engleby. His prose has that flat, stilted quality familiar to the modern reader as a sign of moral vacuity, but does he have to be so uninteresting with it?
The inside of an outsider's mind
The cover of this edition says "Compulsively readable yet deeply disturbing I could see her bare legs. So I eng,eby a vague idea of what to expect with this one ish. This is an intense and heavy read, but worth it in the long run.
Whilst obviously childhood trauma can affect someone mentally, it is entirely plausible for someone to have a similar disorder as Engleby does without having suffered it. The essential gift book for any pet lover – real-life tales of devoted dogs, rebellious cats and other unforgettable four-legged friends.
Engleby is a great character, a supremely intelligent social outcast. Despite this though there are moments of genius as the odd character rambles that you feel he is real.
A past and present that don't add up
Also, Faulks sucks when he starts talking war, politics, our imperfect world etc. It is told as a The cover of this edition says "Compulsively readable yet deeply disturbing Hardcoverpages. A condemnation of drug culture.
Mike fails to attain a first in his final senastian. Engleby is a relatively hidden gem that I have no hesitation in recommending. I can't say I loved it – note the 4 stars.
A past and present that don't add up – Telegraph
He's important because there's something of him, sick as he is, in every smart outsider. And watching a character fall apart and put himself back together fajlks is very difficult to read but you keep doing it anyway because you get sucked in, through layers of stark prose that are still poetic. He begins to steal, at first to pay for letters to his sister, but he soon escalates to frequent theft and begins to buy cigarettes to zebastian on to other pupils.
He lacks empathy but Faulks wants us to know it too badly: The lacuna is most painfully evident in his attachment to a fellow undergraduate, Jennifer Arkland, known as Jen. View all 3 comments. Engleby's memories prompt him not only to historical englebu but also to consider the nature gaulks history, which he sees as somehow compromised by modernity "While the past is real enough – the only true reality – the present has insufficient depth to register it"and of time: I found the prose to be frequently stunning and almost always fluid and smart.
That last perception leads him to the idea at the heart of this novel, that "the defining human faculty – that of self-awareness – is a faulty one, at best partial and frustrating, fauljs worst utterly misleading". I've never been so faluks to a character and simultaneously felt as though I didn't really know them at all.
Mike's darkly humorous, sometimes monotonous in the most literal sense of the word, rather than the emotions it evokes in the reader voice lays bare the social and political landscape of Thatch Against all expectations, and rather reluctantly, I thoroughly enjoyed this novel.
By using this site, you agree to the Terms of Use and Privacy Policy. If you recall student life this is set in the 's when basic parties, and student JCR's were the order of the day; when things were generally uncouth, then Engleby will resonate. Engleby's relationship to the world around him, the way he views his peers for example, is subtly bizarre in the way he is rational and yet weirdly detached.
Mike pleads guilty to the murder of Jennifer Arkland. On a basic level, Mike is a thirty-something writing retrospectively but for some seastian there are a Faulks has a way of writing that leaves the darker side of human nature laid bare on its pages and you are intimately exposed to it.
Without spoiling This is an outstanding novel on many levels. Engleby is set in the s and 80s and gives a first-person account of the life of Mike Engleby, a very intelligent loner and outsider. It is hard etched, grammatically and lexically precise, but it also convincingly recaptures the informality of working class and student slang.


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Why Work Hard For Mediocre Results?
Working your butt off and only getting mediocre results, sucks!
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However, what I can do is offer you help in the website 'technical department', so you can focus on the things that are a better use of your time, money, energy, your essential self.
What do you feel you're wasting time on with your website?


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Hi there,
I have bought and installed Sydney Pro, installed the Portfolio Plug-in and created various posts and projects. link: www.ivantanda.com
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On a block of my homepage I inserted the short-code
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View it here: http://nimb.ws/DWukxf
Unfortunately it shows nothing, I tried messing up a bit but no luck.
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Let's face it. Having a body of an A-Lister takes a lot of work and money. Some resort to plastic surgery while some actually put in the time, hard work, and effort needed to build an incredible body from head to toe. No matter how they do it, celebs are just like us. But, there's no reason to sit around and wonder just how they did it because, luckily, their personal trainers have spilled all of their secrets to getting their most coveted body parts!
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Jennifer Aniston's Legs
Have you ever seen Jennifer Aniston's legs look bad in an outfit? Yeah, me either! Her personal trainer, Mandy Ingber, shares her top 3 moves to keeping those legs in tip top shape.
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We offer a 30-day return policy, as long as: it is not more than 30 days past the date of delivery; and your item is in its original condition and packaging with the original order number. Refunds will be issued when the equipment is received back to the BodyRock warehouse, minus the original cost of shipping, and the customer is responsible for the costs of return shipping. To request a refund on physical product purchases, please contact us.
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We cannot issue refunds on digital goods such as e-books or videos, as these are non-tangible goods that are irrevocable once the order is placed.
All of the BodyRock clothing is made to order and so is final sale. If you have any questions about sizing prior to placing your order, please contact us.


text:
Who called from number 2825448110
Phone number Comment 2825448110 SCAM / SPAM 2825448110 scam...telling me time sensitive...and saying ignore this at your peril..the HMRC will arrest you 2825448110 I don t know anybody in Norhern Ireland so blocked this. But they also had to cheek to leave a voice mail 2825448110 Male automated voice giving female name claiming to be HMRC. 2825448110 Computer generated message saying it's from HMRC?? Hung up as sounded like a scam 2825448110 So fed up off these scammers calling they will be blocked!!! 2825448110 Another cold caller. They left a voice mail after i rejected the call. I won t listen to it incase it leads to something bad. Why do these people bother as most calls don...


text:
Marketing and Public Relations in Dublin
As the capital of the Republic of Ireland, Dublin is one of the liveliest cities in Europe. With one of the youngest populations comprising people from many different parts of Europe and the globe, the city has a full and varied cultural and intellectual life, which brings together the best of traditional Ireland and of modern Europe.
Example intern duties might include client relationship management, event and social media management, developing marketing strategy, analyzing data, website content development, creating proposals, press releases, and communication strategy.
Internship assignments vary. While internships help develop technical abilities, they provide more fundamental life skills. Interns will get an introduction to the professional world as well as the opportunity to gain career ready competencies in critical thinking, problem solving, teamwork, and global and intercultural fluency.
- Excellent written and verbal communication skills with the ability to work independently
- Flexibility to take on multiple job responsibilities, including entry level tasks
- Ability to take initiative, work independently and deal with ambiguity
- Good interpersonal skills and the ability to work on a team
- Strong attention to accuracy, details, and organizational skills
Students will enroll in 2 courses for a total of 12 quarter credits.
Course #1: GlobalWorks International Internship
This internship helps students connect their academic studies to practical applications. Students develop professional skills while gaining exposure to the dynamic culture and lifestyle in their host country.
Course #2: Intercultural Communication (online)
This course is designed to provide ongoing support to students doing internships abroad. Students will observe, explore and investigate the core cultural values in their host country during the internship, conduct comparison in the differences between their host and home country, and develop critical thinking skills and culture learning strategies. A weekly assignment for the online course includes: reading assignments, group discussions and a weekly journal. It will begin one week before your internship begins and end one week after completion. Due to the intense nature of interning, in addition to taking the 4-credit course, we recommend you do not enroll for any other classes during the internship period.
Minimum GPA: 2.75
There are no language requirements, though students with proficiency in the local language will have more internship placement options.
Estimated program costs and a detailed budget of projected expenses can be found on the Locations and Costs page.
Please contact Yifang Zhang, GlobalWorks Program Manager
Email: firstname.lastname@example.com
Phone: 541-346-5088


text:
Home Support Worker
Post: Home Support Worker
Hours of work: Rota based, morning, evening and weekends.
Pay: Grade D - £18,795 p.a. (pro-rata) £10.01p per hr (enhanced for weekend working)
Holiday Pay: Paid Separately
Home Support Worker Team
We are committed to creating a team that will be providing direct care and support to a child in a home setting and in the community. If you have the right skills and experience, then this could be the position for you.
Care is required and will be provided on a rota basis and includes weekend working. Your contract will be for an initial period of 6 months and is complimented by generous rates of pay and enhanced pay for weekend working.
Hours of work vary over term and non-term-time, and include morning, evening and weekend shifts so hours are variable but this opportunity provides for regular hours as part of an established rota, generous pay rates and enhanced pay at weekends - plus you will be working 2:1 with another support worker on every shift
Your care and support will allow a young boy to remain at home with his grandparent by providing personal care, feeding, interaction and play.
Reliability, continuity, initiative, good interpersonal skills and a genuine interest and commitment to meeting the needs of disabled children is essential for what is a very rewarding role.
Equal Opportunities
Please note that all disabled applicants who meet the essential criteria for these jobs (as given in the Person Specification) and who want to apply under the Disability Confident Scheme will be invited to interview.
How to apply
Please apply online via the link provided. Please note, we do not accept CV's (unless specified on the advert). Please fully complete the online application form.


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- Publication date
- 24th September 2015
- Information type
- Decisions
- Policy area
- Gas - distribution
This document summarises the results of the first RIIO-GD1 Gas Discretionary Reward Scheme 2013-15. Through this scheme, we aim to reward the performance of Gas Distribution Network (GDN) companies which best serve the interest of customers through initiatives over and above what GDNs have been funded for within RIIO-GD1.
The scheme assesses companies on their initiatives across three categories that we specified: environment, social and carbon monoxide safety. This was the first assessment for RIIO-GD1 and a total of £4 million was available to reward the GDNs.
We decided to award £3.05million of the available £4million for this assessment. Our decision was based on the recommendation made by our independent panel of experts that assessed each of the submissions. We will undertake two more such assessments awarding up to £4 million during this price control (by 2021).


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Chalet Chantelcair A is a fantastic property in one of the most enviable locations at the top of Meribel, right on the Rhodos piste meaning instant ski in/ski out access onto the blue run connecting to the main Chaudanne lift station and Altiport pistes.
Cot and Highchair
Dogs Allowed
FREE Wifi Access
iPod docking station
Optional Extras
Towels & Bathroom Accessories
TV and DVD Player
Chalet Chanteclair A is a superb top floor apartment-style chalet that has proved a hugely popular part of our programme for years. This is no doubt down to the huge amount of space it provides combined with probably one of the most enviable locations in Meribel.
Positioned right on the edge of the blue Rhodos piste leading down to Chaudanne, access to connections into the vast Three Valley circuit is absolutely second to none. Perfect for avid skiers, this apartment will not be so popular with real party-goers as the centre of the village is about 20 minutes walk downhill although the local free bus stops nearby. Apres-skiers though will be pleased to hear that the infamous piste side Ronnie Bar is just a short ski away with its popular live music!
The apartment itself is traditionally decorated and has loads of space. The bedrooms are all ensuite and the open plan living/dining room has an impressive high pitched ceiling, plenty of sofa seating and large open log fire to enjoy a nice chilled glass of wine at the end of a strenuous day on the slopes. This property really is a popular choice for smaller groups of friends or families who are keen to maximise on valuable ski time and you will be warmly welcomed by one of our hand-selected chalet hosts who lives out. (other chalets in meribel)
Did You Know... Chanteclair A is such a super property, it is hugely popular with our repeat guests and is often our first chalet to sell out in Meribel, therefore you'll need to be quick!
Average snow history
Weather 6 October 2017 8:00AM
501 cm
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347 cm
624 cm
469 cm
6 October 2017 8:00AM
Average snow history
Weather 6 October 2017 8:00AM
With Alpine chalet charm, nestled in the centre of the vast Trois Vallees ski area, Meribel Ski Resort often tops the best resorts in the world list for its combination of world-class skiing, amazing in-resort facilities, and a vibrant nightlife. There are a huge amount of restaurants that will meet all needs, from traditional Savoyard food to classic pub grub and ski in, ski out huts hidden in the trees.
The best thing about Meribel is its location. Right in the middle of the Three Valleys, which has a massive 600km of skiable terrain. Meribel rarely disappoints and often captivates. Click and see for yourself...
Meribel piste map
501 cm
459 cm
347 cm
624 cm
469 cm
6 October 2017 8:00AM
If you book your flights with us you can book a shared or private transfer from the airport to the resort as part of your booking. Even if you don't book flights through us we can organise transfers for you - just give us a call on +44 (0) 208 877 8882.
We know how valuable your skiing time is to you so that is why we can to pre-book your lift passes for you, to save you the time and hassle of doing it once in resort. And most importantly, no additional charge or hefty currency bank charges! The lift passes will be ready and waiting for you in your chalet/hotel/apartment, so you can hit the slopes immediately... You can book these at any time after you've booked. Call us on +44 (0)20 8877 8888.
The last thing you want to do at the start of your holiday is queue up in a crowded ski hire shop. We understand this and that is why we offer to pre-book all your equipment so that it is ready and waiting for you. You can either collect it from the shop yourself or some shops even offer a chalet fitting service, where all the equipment will be brought around to the chalet, thus avoiding the ski hire shop completely. Call us on +44 (0)20 8877 8888.
Ski school can be a real hassle to organise so let us do all the hard work for you. We have built relationships with the top ski schools in most ski resorts and we can book lessons for all ability levels, both private and group lessons. For Christmas, New Year, Russian New Year and February Half Term, we strongly advise pre-booking your lessons as soon as possible as the group lesson and private lesson slots get booked up very quickly. You can book lessons at any time after you've booked. Call us on +44 (0)20 8877 8888 or fill in the Ski-School Request Form
Transfers from the airport to your accommodation and vice versa is available through Powder White. If you need transfers arranged, please contact us on +44 (0)20 8877 8888 or fill in the Transfer Request Form
Is not included and, on chalet bookings, will be added to your confirmation invoice. Local Tourist Tax for Hotels & Apartments is payable directly to the supplier in resort.
Each chalet booking requires a deposit of between £250 & £500 which is held as security against any damages, breakages or monies owing to Powder White. Details of this will be shown on your Confirmation Invoice and further information can be found in our Terms section. Apartment Residences vary so please enquire at time of booking.
Powder White is an Independent Tour Operator offering you an informative, personal and tailor-made service. Our friendly Sales Executives are here to help, so if you have any questions, need further information, or if you have specific requirements you'd like to discuss with us, please feel free to just get in touch and we will do everything we can to find the perfect skiing holiday for you.
Why not give one of our friendly ski experts a call?
There has been a problem with this booking, please call us on +44 (0)20 8877 8888.


text: Setting Yourself Up For Success With Higher Education There is no doubt that the process of earning a college degree is a daunting prospect for many. It is possible to demystify things to a significant degree and make wise decisions about your future, by conducting a bit of research on the subject. Keep reading for some terrific advice about the right steps to take. No matter how long it may seem to take or what you have to go through in the process, don't ever give up on your collegiate career! In the end, that certificate of graduation will be well worth whatever you have to do to get it, though in the heat of the moment, something or someone may hold more appeal than all the studying and endless exams. If you find yourself falling behind in a class, do not hesitate to consult your professor. Check with your school's faculty directory to find out his or her office hours. Make time to stop by an express your concerns. Your professor wants you to succeed and can direct you to the best resources. College is filled with a lot of stress as the best thing that you can do in regards to school is to prepare in advance. Avoid procrastination at all times, as this will only add to the stresses that you already face. You can feel prepared and organized as college goes on, by doing your work ahead of time. Make certain that you have your FAFSA submitted very early in the year. This is the financial aid that is automatically given by the government. The earlier you apply, the more certain you are to receive your benefits. Sometimes, the finances can run out, especially at smaller educational institutions. Be prepared! In your first year of college, one of the things that you will want to avoid is a relationship. A relationship can be very difficult when your main goal is to get acquainted with an area and to meet new people. Save this for the later years that you are in college. Develop good study habits while in high school. College professors normally expect that students in their classes know the proper way to study for exams, write term papers and how to research information. By learning this while in high school you can ensure success in college. Ask for help if you do not have good study habits. Student associations and organizations aren't just about looking good to a prospective employer. Participation can benefit students as well, both emotionally and socially. You'll find others who share your interests and can explore more of your options on the campus. You might also gain insight into whether or not your chosen major is the best decision. Don't take too many hard classes at one time. If you take on too much, it can lead to a poor performance in even your easier classes. Try taking some classes that you can breeze through and some that might pose a challenge. Make sure you take care of yourself when you are away at school, get plenty of rest, drink plenty of water, and try to eat three meals a day. This will keep your sharp as a tack and ready to tackle even the hardest term paper that your professor throws at you. Avoid the urge to overeat if you are living at the dormitory. Most schools offer up a buffet-style selection with a wide variety of selections that can be tempting, but overeating can lead to health issues as well as take away from the energy needed to focus on your academics. Sign up for the starting classes related to these majors if you need help choosing between multiple majors. You can take time to decide on your major, by getting your core classes out of the way. Plus, you'll be earning credits that will count toward your major, and possibly enough credits in another subject to earn a minor as well. If you are looking for a way to pay for college, do some research on scholarships. Many affinity and corporations groups set up scholarships that college applicants can apply for, based on a certain set of criteria. You may be surprised at what you can qualify for. Before you look into it, do not rule out an opportunity. Get to know the people in the financial aid office. If you make friends with them, they will appear more friendly to you. Then, when you have questions, they can assist you more easily. While they are all professionals, it never hurts to grease the social wheels when it comes to your financial needs. If you feel your schedule can handle it, take an additional class during each semester. Many students can easily handle the average class load, which means that adding in one more class will be a minor burden at best. This can allow you to shorten your time in college enough to graduate a little earlier. Does the thoughts of leaving home scare you? Then consider taking a few online college courses to help build your confidence. There are also community colleges, which allow you to live home and commute to college. This will permit you to still have time with your family while getting an education. Join study groups. Even if you are not having trouble with a class, a study group can help ensure you stay on task and don't fall behind. It can be easy to fall into the trap of procrastination, and a study group can help provide accountability. In addition, helping others understand the coursework can help it stay fresh in your mind. Do not sign up for college if you are not sure of what you want to do after you graduate. If you have a clear idea of what kind of career you want to have after you finish college, going to college is expensive and this investment will benefit you. Not all instructors will take attendance in the classes you take, but you should attend all the classes you signed up for. Paying attention in class, taking notes and participating is the best way to learn something from your classes. Do not hesitate to talk to your instructors if you are having difficulties. The potential benefits of college are innumerable. That's why so many people are interested in the subject of college even though attending is not easy. The advice you're about to read should help you when making decisions regarding your education. 卡式台胞證照片辦理申請過期費用臺胞證台灣居民來往大陸通行證 清潔公司台北新北推薦費用居家清潔打掃冷氣 徵信公司徵信社推薦討債抓奸費用外遇找人離婚征信社尋人欠債抓姦抓猴跑路 台北植牙牙醫診所牙科新北費用假牙牙套牙橋 台北隆乳醫美微整形隆鼻美白針診所玻尿酸音波拉皮墊下巴肉毒桿菌雙眼皮自體脂肪隆乳 新北外燴餐盒台北茶會點心餐飲推薦外烩 近視雷射眼科診所白內障手術散光 室內設計裝潢翻新居家客廳裝修老屋設計圖室內設計師 會計師事務所成立營業商工商業公司登記記帳士 安養院安養中心長照2.0護理之家養老院失智症 漏水屋頂抓漏防水費用壁癌 消滅蟑螂老鼠防治消毒滅蟑公司蜘蛛跳蚤除蟲果蠅白蟻紅火蟻


text:
GWU - 2020 Intellectual Property Networking Reception
The Marvin Center - Continental Ballroom
800 21st Street NW, 3rd Floor
Washington, DC 20052
United States
The George Washington University Intellectual Property Networking Reception is an excellent opportunity for students to meet with prestigious legal employers and learn more about the variety of work an IP attorney can do.
Knobbe Martens is looking for 1L, 2L, and 3L Law Students with an interest in IP law. Meet with lawyers from one of the country's most prominent intellectual property law firms to learn more about our practice, our people, and why we offer an opportunity second to none to build a rewarding career in IP law.
No CLE credit available


text:
Manager Steve Bruce has said he believes that Aston Villa's squad is 'far better and far stronger' than we were last season as we look to mount a successful and serious promotion push from the Championship back to the Premier League.
Speaking to the Official Site in his now usual Monday morning briefing about things claret and blue, Bruce explained that with the strength of the group, he was confident we could mount a serious push for promotion this year and achieve the aim that he was set when coming to B6 in the first place.
With the Championship kick off now a week away, well less than, with Hull City up on Saturday, Bruce explained.
'I like our balance. The lads we have brought in will certainly improve us with our experience. We look far better, far stronger and better equipped in terms of the experience we`ve got. Whelan, Elmohamady and Terry bring great experience and know-how.'
Bruce went on to say.
'I do feel you need that to play for this club and they will handle it because they have played in the Premier League before many times. I`m very confident they will perform under pressure – like you have to playing for this club.'
Whilst he wouldn't be drawn on a potential starting eleven for the game, Bruce did say that the line up against Watford did offer up some clues and fans shouldn't expect too much difference.
'I`ve got an idea. You won`t be far away with what we had against Watford.'
That's certainly get some tongues wagging given both the sides we started with and then ended with.
Join Vital Villa
It's easy to REGISTER, simply click the link and enjoy getting involved!


text:
De heer Van Benthem en de Toinettes ZH, The Netherlands
"De heer Van Benthem en De Toinettes" are performing hits and nearly hits, that find their origin in the middle of the last century, in the classical combination of crooning, guitar and polka-dot close harmony background vocals. Solid musical arrangements, authentic enthousiasm and light irony creates a unique style that gives them the chance to share their musicality with a broad audience. ... more
Contact De heer Van Benthem en de Toinettes
Streaming and Download help
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text:
Enter a valid city, state or zip code
Enter a valid city and state or postal code
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Need a flower delivery for free in Phoenix, AZ? How does a cash bonus for selling your unwanted gold jewelry sound? Sell your gold and get instant cash plus more at fine jewelry stores in AZ. Just make sure you bring in the coupons found here on Valpak.com. We also offer savings on many specialty store services like vacuum cleaner service and sewing machine repair. We even have eyeglass coupons and savings on your next contact lens exam. We have the contact lens solution to paying less for your eye wear and eye care. See us first and save.
Valpak is at the heart of communities across North America, helping people save, businesses grow and neighborhoods thrive through a network of local franchisees in the U.S. and Canada.


text:
How Lisp's features are related to the capacity of defining DSLs?
First of all, we need first-class high-order procedures.
Actually, it goes a bit deeper - because every symbol is a reference (a pointer) to some value (NOT an object, just a value) then everything, every value that we could bind a symbol to is first-class. This is a consequence of the uniform, general rule - everything is a pointer.
Another important moment - symbols are just symbols (they are mere names, labels attached to a value) it is a value itself that has a type. Type is attached to a value as a tag.
Logically, each value has zero (when a self-evaluated value - which represent a number or a string - is used explicitly), one or many names (symbols) associated with it, and one or more type-tags attached to it. This is also uniform, general rule.
Together we have very unique trait of Lisps - we could reference and pass everything everywhere, and types are checked at run-time, so, no, it won't add 3 to "4".
Functions, then, are just values with some type-tag attached, which gives to a compiler (or an interpreter) information that this value is a function.
Let's see how it works. Remember what a special form is logically? It is a Lisp expression which has its own, unique evaluation rule, which is different from the uniform general evaluation rule for all Lisp expressions (which is: 1. eval all the given arguments in order. 2. apply the procedure (which is always in the car of an expression list) to the values of the arguments).
There is a special form called do (or begin, or progn)
The special form do
(do forms) is equivalent to an in-place invocation of a lambda expression containing given forms as its body
((lambda () (forms))
Remember what is a macro logically? It is a procedure that perform a syntactic transformation of a lisp expression at read-time, which is just a stage (a pass) before compile-time and run-time. It produces new Lisp expressions, which are semantically equivalent, to be compiled (or interpreted).
Now what is a macro technically?)
in Arc it is just a procedure, annotated with type-tag 'mac
(assign do (annotate 'mac (fn args `((fn () ,@args)))))
So, a macro is just a lambda (what else could it be?'')
In classic Scheme it could be
(define-syntax do (sc-macro-transformer (lambda (exp env) `((lambda () ,@(cdr exp))))))
where this
,@(...) form is just "unquote-splicing this in-place created list".
Let's do it again slowly. This time we will define the
let special form.
Have you already realized why we are bothering with all this - macros are the way to add new control structures (special forms) into the language. This is the first glimpse of real power of Lisp - it is a layer upon a layer of DSLs, where each new DSL is written in terms of previous ones. The Lisp itself is just a very few special forms
lambda define if set! and primitive procedures
cons car cdr pair? null? which are used to create (glue together) any kind of compound data structures. and
read eval apply quasi-quote unquote, etc.. which are at the core of a Lisp.
Let's add let to a Lisp.)
; the local binding form (let ((x 1)) x) 1 ; is equivalent to implicit invocation of a lambda with corresponding parameters ((lambda (x) x) 1) 1 ; a syntax transformation, such that expression (let ((x 1) (y 2)) (+ x y)) 3 ; becomes ((lambda (x y) (+ x y)) 1 2) ; is called Macro Transformation 3
Let's understand the structure of a let expression.
; bindings is a list of pairs, where car is a symbol and cdr is a value '((a 1) (b 2)) ; to get a list of symbols (map car '((a 1) (b 2))) ; to extract a list of values (map cadr '((a 1) (b 2)))
Now lets write this syntactic transformation in terms of what we have
(lambda (bindings . body) `((lambda ,(map car bindings) ,@body) ,@(map cadr bindings)))
This is "close to an ideal", not yet complicated or cluttered definition of a procedure which perform a syntactic transformation, by manipulating Lisp forms at the read-time.
Now we must somehow annotate it as a macro, which means to tag it with the type (tag) "macro" - so it would be recognized as a read-time instead of run-time procedure.
Unfortunately, classic Scheme has this wired syntax
; too much boilerplate, too cumbersome, redundant let, non-intuitive destructuring. (define-syntax lett (sc-macro-transformer (lambda (exp env) ; evaluate exp in env (let ((bindings (cadr exp)) ; destructuring (body (cddr exp))) `((lambda ,(map car bindings) ,@body) ,@(map cadr bindings))))))
Logically we cannot use let for in the definition of let, so
(define-syntax lett (sc-macro-transformer (lambda (exp env) ; always the same parameter list `((lambda ,(map car (cadr exp)) ; ugly in-place destructuring ,@(cddr exp)) ,@(map cadr (cadr exp))))))
While in Arc it is just
(mac lett (bindings . body) `((fn ,(map1 car bindings) ,@body) ,@(map1 cadr bindings)))
which is much more intuitive, clean and beautiful, as it supposed to be within Lisps.


text:
Government urged to free detained journalist
South Sudanese authorities should immediately release a journalist who has been arbitrarily detained, Human Rights Watch said today.
The National Security Service (NSS) arrested and detained Emmanuel Monychol Akop, the editor-in-chief of The Dawn newspaper after he answered a summon on October 21, 2019 to appear at the security service headquarters in Jebel neighborhood of Juba.
Monychol's arrest appears to be linked to an October 15 Facebook post in which he poked fun at the dress worn by the foreign affairs minister, Awut Deng Achuil.
"Emmanuel Monychol's detention is just the latest act of harassment by South Sudanese authorities in response to criticism or perceived dissent," said Mausi Segun, Africa director at Human Rights Watch. "The authorities should immediately release him unless he has been charged with a recognizable offense."
Four days after Monychol's arrest, he was released on bail to attend the burial of a relative and other family functions. He responded to a second security service summons on November 4 and has been in custody ever since. On October 29, while out on bail, Monychol apologized to the minister for his comments on Facebook, which were also published by The Dawn newspaper the next day. Since 2017, the minister has had a defamation case in the high court in Juba against Monychol and The Dawn newspaper.
The National Security Service Act (2015) grants the security agency sweeping powers to arrest, detain, conduct searches, and seize property. The law, however, requires the NSS to bring detainees before a magistrate or judge within 24 hours of their detention. Detainees under NSS detention are often kept in poor conditions including in congested cells with inadequate access to food, water, and medical care.
South Sudan's peace deal signed in September 2018 provides for the review of security sector laws including the NSS Act by the National Constitutional Amendment Committee. In January, this committee submitted proposed amendments to the NSS Act to the Justice Ministry for deliberations and for presentation before the National Assembly. The ministry has yet to transmit the amendments to the assembly.
"South Sudan's authorities should expedite action on the necessary reforms to curb the security agency's broad powers and ensure full compliance with existing legal safeguards," Segun said. "They should also ensure broad-based, public, and transparent consultations during the review process."


text: If meth abuse is continued about a long period of time, the Mind begins to rely on its results and produces a need for its use. Long-phrase methamphetamine abuse has several damaging penalties, which includes habit. Addiction is often a Persistent, relapsing illness, characterized by compulsive drug searching for and http://how-long-do-meth-addicts13344.aioblogs.com/20056179/how-long-do-meth-addicts-live-for-options


text:
In a world of solar panels and fusion reactors, the inside of a battery might seem like energy science at its most basic. Professor Yang Shao-Horn's work with batteries and fuel cells, however, is anything but.
In 2008, a team Shao-Horn was a part of captured the first atomic-scale compositional images of fuel-cell nanoparticles. She followed this up with the discovery in 2011 of a new catalyst capable of speeding up water oxidation. This, along with her establishment of a new design principle to govern oxygen electrocatalysis, have been critical steps forward in the study of in advanced energy storage systems.
Since then, Shao-Horn, the Gail E. Kendall Professor of Mechanical Engineering at MIT, has turned her skills to several other battery-related areas of study, including work with modified viruses that could hold the key to boosting lithium-air battery performance.
Shao-Horn is not daunted at all by these creative reimaginings of some of the most central tenets of energy science. As a child growing up in Beijing, she preferred multi-faceted puzzles to standardized exam questions. "I enjoy adventure and like to sense the unknown," she says. "That's why I like to work on open-ended problems."
As part of MITEI's support for the Clean Energy Education & Empowerment (C3E) Initiative, or C3E, MITEI will periodically be featuring profiles of women in energy on our website. Outstanding women are making an impact in clean energy! Find out how – visit c3eawards.org


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Las Vegas create signs online allows you to design and order your own sign online in the privacy of your own home or office. Innovative design programs are now available online to assist you in creating your "perfect" sign or banner and add those personal touches to the banner.
Many people and businesses are just too busy during normal business hours to create their own sign or just work unusual hours when most businesses are closed. This is normal in Las Vegas where the town is considered a 24 hour town. Many sign shops in the Las Vegas area allow you to create your own signs through state of the art design programs that give you the tools the professionals use. Las Vegas create online signs gives you 24 hour access to sign making.
Las Vegas create signs online allows you to choose from many templates and the clipart feature allows many different types of options. Also, with these design your own signs online programs, you can import your own artwork or pictures to be included in the custom design. The automatic cost of the sign is always known because it is prominently displayed when you size your design in your choice of substrate.
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Results for "Inner Ear"
Mystery Orchestra with Grenager & Talfjord
Label: Inner Ear
Released: 2011
Track listing: Hansen's Stroll; Derrick At P1; Albatrosh On Skies; Bubba The Hut; Mystery Orchestra; Rapla; Albatroshing; Shades of This.
Albatrosh: Mystery Orchestra with Grenager & Talfjord
Duos can represent a double-edged sword: on one hand, no other context is as intimate, where the level of communication can be as deep, the lines of communication so open; equally, however, there are the inherent limitations on its possible sound worlds, the result of the specific textural, harmonic and rhythmic capabilities of the instruments involved. ...
Mystery Orchestra With Grenager & Tafjord
Label: Inner Ear
Released: 2010
Seagull Island
Label: Inner Ear
Released: 2009
Track listing: Gambler; Pölva; Valium; Mr. Fixit; Third March; Matrosh; Mystery of the sound <
Albatrosh: Seagull Island
While catching some of Norway's biggest stars was one of the attractions of JazzNorway in a Nutshell 2008, so too was the discovery of young talent, in some cases not yet recorded. Albatrosh--the duo of tenor saxophonist André Roligheten and pianist Eyolf Dale--delivered an unexpectedly experimental and engaging performance at a brief overnight stop in Rosendal, ...


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ISCM Virtual Leadership program
Resolve – Resilience – Return - Reimagine: Supply Chain Thinking for a Post-COVID-19 World
A series of 8 sessions leading you through the process of restructuring your supply chains
Second Batch Launch Date: 26th September 2020
Uncertainty is the biggest enemy of traditional efficiency focused supply chains. Supply chains has been planned on the basis of deterministic models. This Pandemic has exposed this linear thinking. In this program the participants will develop an understanding of how traditional efficiency focused thinking has led to the unhappy outcomes currently being experienced by both business and society due to the COVID-19 pandemic. Building on this understanding, participants will be led through a process for restarting their supply chains and re-engaging customers. The focus will be moving towards resilience based supply chains from deterministic ones.
Who is it for:
• Supply Chain Professionals
• Logistics & Customer Service Professionals
• Consulting Professionals
• Procurement Professionals
• Finance Professionals
• Operations Professionals
• Demand Planning Professionals
• Supply Planning Professionals
Program duration:
Eight, 90-minute, weekly sessions Wednesday and Saturday, beginning 19 Sep. (6 - 7:30 pm IST)
The pedagogy includes Interactive virtual classroom, case study,Scenario building, Peer to peer discussion and group work
All who complete the program willbe a Certified Supply Chain Leader.
Learning Outcome
The focus is on building a resilient and competitive supply chain. Starting from a new thinking about suppliers and strategic procurement, Risk assessment and risk mapping, demand planning, last mile delivery, distribution planning, managing the factory of tomorrow, digitalization and connected planning and the new Integrated business planning. Participants will be challenged to consider what changes will be needed and a framework will be discussed for the gradual restarting of operations and for re-imagining and building resilient supply chains.
The program will build the future practices required to deal with black swan events as well as political turmoil, environment challenges, natural disasters. Each session's learning outcomes, valuable for the particular topic covered in the session, will increase in value as subsequent sessions build on the knowledge and skills built in prior sessions. On completing the eight sessions participants will have learned how to plan for a future that is unlike the past, what the costs of such a future might be, and how to make informed decisions on the best way to address the uncertainties that might present themselves.
Course Outline
This program consists of four modules, spanning eight 90-minute sessions, each focusing on a different aspect of rebooting your supply chains. Starting with an assessment of the current state – the "Resolve" phase and going through to the final step "Re-imagine" Phase– creating a whole new strategy for the organization.
The course will cover
• Understanding what happened and why
• Creating resilience in our supply chains
• The challenges and frameworks as we restart our operations
• Rethinking the future
• Planning for the future
For further details please contact:
Girish VS | 9867826787/7021267306 | email@example.com
Marketing Team:
Jesal Tanna | 8369646846 | email@example.com
Sanjay Pal | 7666438880 | email@example.com
Pallavi Nagvekar | 9820690725 | email@example.com
Let's keep in touch for R4: Virtual Leadership Program


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EDMONTON – After a one-year delay, there's a light at the end of the tunnel. City officials say there's been significant progress at the Walterdale Bridge site.
The steel arches are starting to come together and the next big step will come mid to late November.
Ryan Teplitsky with the City of Edmonton says "We aren't there yet by any means. We have the most complicated part of the project coming forward."
That's when the arches will be rolled out onto rails, onto a huge barge and maneuvered up the river. Cranes will help attach it to pieces on either side of the river.
Part of the further delay was due to water levels. Floating a 950-tonne arch needs a river that's at least 2.1 metres deep.
"The contractor went ahead with the dredging just to make sure we'd be able to get the barges across. There's a lot of work making sure we have the arch ready. There's a lot of geometry to check and survey," explains Allan Bartman with City Roads Design & Construction.
Construction at the Walterdale Bridge site Thursday, Oct. 22, 2015. Fletcher Kent, Global News
Construction at the Walterdale Bridge site Thursday, Oct. 22, 2015.
Fletcher Kent, Global News
The reason for the original delay was the steel required to build the new bridge arrived months later than planned.
The city is still aiming for an opening date for the fall of 2016.
Construction on the bridge started at the beginning of 2013.
Edmonton's Walterdale Bridge facing a lengthy delay
Walterdale Hill closure starts Monday for bridge construction


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even Glass.
* All prices quoted are for loose items i.e Parts removed and refitted by customer.
* We do not remove or refit tyres but can arrange for this at extra cost.
* If you require us to remove and refit parts this will be priced extra.
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Heavy rain and floods are affecting Mozambique since the beginning of March, causing extensive damage and deaths. Tropical Cyclone IDAI made landfall near Beira city (pop. 530 000) in Sofala province (Mozambique) on 14 March evening, as an intense Tropical Cyclone. Strong winds (max. sustained winds 170-180 km/h, with higher gusts), heavy rains and a large storm surge (calculations: up to 4.5 m) affected this area. After the landfall, it moved over Mozambique towards eastern Zimbabwe, weakening. However, the remnants of IDAI are still producing heavy rainfall, with additional flooding.
Photo Credit: After the passage of TC IDAI (source: WMO)


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June 4, 2018, San Francisco, CA
Jews for Jesus said, "Behold Your God Jerusalem," in an unprecedented way this past month. With over 200 staff and volunteers participating, the group engaged in over 5,000 conversations with Israelis about Jesus one on one and had over 200,000 check out their social media posts. In addition, they got the names and contact information of 1,747 Israeli seekers who want to know more about Jesus. During the four-week outreach, 58 Israelis responded to the message by embracing Jesus as their personal Messiah. And Jews for Jesus expects to see this number increase as their regular presence there continues. Jerusalem is home to 750,000 Jewish people and the focal point of world attention, especially in light of the recent opening of the U.S. Embassy there and the activities surrounding the 70th anniversary of the modern state of Israel.
"Behold Your God" is an eighteen-year effort by the organization to conduct in-depth evangelistic campaigns in every world city with a Jewish population of 25,000 or more. Of the 77 such campaigns that have taken place, this one, centered in Jerusalem, is the "grand finale." However, Jews for Jesus Executive Director David Brickner says "This is just the beginning of a new era of outreach for our 45-year-old organization. We are reaching out to all kinds of people in the city: university and yeshiva students, artists, millennials, boomers, sports enthusiasts, Russian speakers, those trapped in addiction, the poor and the Haredim (Orthodox Jews). We have experienced relatively little opposition and lots of enthusiastic engagement." He went on to say, "When Jesus walked the streets of Jerusalem, he also had a diverse audience, from tax collectors to beggars to teachers of the law and wealthy business folk. We think he set the precedent for us in 2018 and beyond."
Unlike previous efforts, Jews for Jesus significantly stepped up the diversity of their approaches to this complex city. Most people recognize that Jerusalem is beset with conflict between religious and secular Jews, between Jews and Palestinians and between followers of Judaism, Islam and Christianity. However, some don't realize that of all the cities in Israel, Jerusalem has the highest poverty level and is fraught with a multitude of social ills. Part of the Jews for Jesus approach is to serve the city and encourage others to do the same. "As believers in Jesus, we see how our Messiah lived for others and we want to follow in his footsteps. We are feeding the poor, cleaning up parks and renovating houses and, in the process, demonstrating that the One we believe in wants to heal that which is broken or in need," says Dan Sered, Israel director of the organization.
Jews for Jesus has offices in Tel Aviv as well as in 27 cities around the world. The next center going forward will be in Jerusalem. For interviews, contact Susan Perlman in the U.S. at 415-740-5006 (cell) or at @SusanPerlman1
galleries below
1. Israeli seekers of all ages stop to talk to our campaigner on the streets of Jerusalem.
2. An exhibit of Chagall art on display has Russian-speaking Israelis engaged along with a lecture on the place of Jesus in Jewish art.
3. A crowd of interested Russian-speaking Jerusalemites listens to the lecture on Chagall and the place of Jesus in Jewish art.
4. A conversation in an open air music venue provided a relaxed atmosphere for conversations about Jesus.
5. Adel Ben David sells her creations along with other vendors, but conversation often turns to the Creator himself.
6. Engaging with a student at Hebrew University, one of hundreds of conversations that took place over the month-long outreach.
7. David Brickner, international executive director of Jews for Jesus.
8. Dan Sered, Israel director of Jews for Jesus.


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Sorry for the light posts today. It has been a busy day and when traffic runs light at Red State, I feel an obligation to post there to keep traffic up.
Anyway, this evening I had a meeting at church. I have been nominated to be a deacon and must, therefore, go through training. The Presbyterians (PCA) take the Bible literally, which is good, and, as a result, the qualifications of Ephesians must be met. The Deacons handle the physical church and the Elders handle the spiritual church. It is a good division. The Deacons maintain the physical structure of the church and its property so the Elders, including the Preacher, can focus on the spiritual concerns of the church.
Tonight we studied by the Presbyterians do infant baptism. I'll keep you updated.
In other news, Mary Frances Berry decided to resign her position at the Civil Rights Commission, even though her term expired Sunday. Ms. Berry, never one to go quietly, faced a President who had the nerve to drive her from office. Well done Mr. President and good riddance.


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The 15th annual Community Dinner will be held Sunday at 1 p.m. at the McDougle School Cafetorium.
The community-building event will feature a full lineup of entertainment and a menu coordinated by Mildred "Mama Dip†Council including food donated by a number of local restaurants.
Tickets must be purchased in advance and are $8 for adults and $3 for kids 10 and younger. Tickets are available at the Carrboro Branch Library, the Carrboro Cybrary, Mama Dip's Kitchen, the Orange County Library, Townsend Bertram, The Ink Spot and other locations.
For more information, visit communitydinner.org


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Little strange as there's been nothing from any of the official coach accounts or uhcougars accounts. Saw this commitment on twitter this morning and JD confirmed.
Keandre is originally from Columbus, OH and is now at Fullerton College. Last year, they went undefeated and won the CCCAA Football Championship. Keandre played in 9 games, made 7 tackles and had a pick.


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Today we look at the Mistel Barocco, a board that had been requested before, but which I now got through a commercial donation. An ergo board with MX Brown - I know what you're thinking, but no, this is not a joke :p . I try to be serious anyway. Most of the time :p .
Mistel Barocco MD770 keyboard review (Cherry MX RGB Brown)
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Saw the dentist yesterday - they couldn't find anything wrong on the X-rays, but I'm to call them on Monday to double-check. And I made an appt. with the chiropractor for tomorrow morning, but right now I hurt. Crap.
ETA: Wonder if the fistula the hygenist found was due to a gum infection? I've had one before...maybe that was it.


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I'd fuck the shit out of him with my big cock
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Von diesen zeigefreudigen alten Schweinen kann man lernen. Ich habe einen Steifen.
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