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End Times.
Take a look at the following video. Take it to the Lord in prayer.
Take a look at the following video. Take it to the Lord in prayer.
Thank you, Tony, this should be aired on every television station in the USA nightly news and preempt every other bit of news for a week!!!
Pingback: God's 'sign language': follow-up to EU-web #2 – Obadiah 15, '666', EU-split | Richard's Watch
"We all have a story, every single human being alive does, but it doesn't become a testimony until we tell it."
Drowning in the busyness of life, and how I stay afloat, and find peace and stillness amidst the chaos
Bible teaching on living victoriously in Jesus Christ through the power of the Holy Spirit!
Isaiah 62:10 "Go through, Go through the gates! Prepare the way for the people, Build up, Build up the highway, Take out the stones, Lift up a banner for the peoples!
There is no power above us or beneath us—no power that could ever be found in the universe that can distance us from God's passionate love, which is lavished upon us through our Lord Jesus, the Anointed One! Romans 8:39 TPT
Dreams and Visions
Now when these things begin to happen, look up and lift up your heads, because your redemption draws near." Luke 21:28
Promoting inspired wellness and New Life of spirit, soul and body!!!
Adopted to Kingship. Anchored in Christ. Encountering Heaven in realms of glory
A blog about my spiritual journey in the Lord Jesus Christ.
Heaven Culture
John3:30-He must increase but I must decrease. Join in elevating Jesus!
Pastor Lydia
Spontaneous blogger, author and founder of Writeous Books
Here Be Dragons, Here Be Dreams
Be Inspired, Be Motivated, Discover The New you.
365 Days with Our Lord Jesus Christ
I can guarantee this truth: Those who believe in me will do the things that I am doing. They will do even greater things...! Jesus, John 14:11-13
Following CHRIST


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Bubba Organics Australian Kakadu Plum & Marshmallow Baby Bottom Cream 125ml
What's cuter than the darling bottoms of May Gibbs' iconic gumnut babies? Your bubba's bottom, of course! Life can be hard on a little toosh with all that nappy-wearing so that's why our antioxidant-rich and extra-gentle Australian Kakadu Plum & Marshmallow Baby Bottom Cream is just the thing for precious little bottoms. Gently calm and protect your baby's delicate bottom area with this deeply nourishing cream. Australian Kakadu Plum enriches this pure formulation with Vitamin C, while the Aloe vera, shea butter and rose geranium oil soothe and safely restore moisture to the skin. Choose planet-loving, all natural baby skin care that's locally made and owned.

subset: commoncrawl


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Exploring Microsoft Azure Free Account [Video]
This 10-minute walkthrough of Microsoft's newly announced Azure Free account will show what services you have available for your cloud projects.
Join the DZone community and get the full member experience.Join For Free
In this video, we will explore what goes into an Azure Free account. The new Azure Free account provides Azure customers with $260 (USD) credit for the first 30 days to experiment with a combination of services. Now it also includes 12 months of popular free services and 25+ always free services to learn and explore Azure further.
You also pay nothing until you choose to. Microsoft Azure uses your credit card information for identity verification, but you will not be charged until you choose to upgrade.
And if you still have questions, check out the Azure Free Account FAQ.
Thanks for watching.
Happy Azure coding!
Opinions expressed by DZone contributors are their own.


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June 6, 2014
Electronical Reeds label is an open-minded platform that has become home for a crew of artists each with their own personal musical touch. Dancefloor driven cuts and melodic grooves form the artistic direction of the brand that emerges from a subtle mix of deep, tech and UK flavored house sounds. The present EP is signed by Superdrums with Lex Newton, another label regular, providing a top notch remix to ensures once again a great package from the label.
May 28, 2014
British electronic group Clean Bandit emerges on the scene with a four-week #1 stronghold for "Rather Be" featuring Jess Glynne (Atlantic UK / Big Beat Records), a feat only held by Adele (for "Someone Like You"), selling in excess of 500k singles to date (and 160k in the first week!) The band also heralds a two-time victory for the weekly UK Shazam tags, overthrowing Robin Thicke and Daft Punk, and this week smashing their very own first record with 1.2M streams.
May 20, 2014
As on the highly acclaimed, best-selling precursor album Arabian Horse, Crossfade is a track that brings together its ideas in a stunning whirlwind of locomotive bliss that is as loco as it is exhilarating. It's up to the remixers to cut through the defensive wall of diamantine melodies and monomaniac narration to vivisect the inner workings.
May 20, 2014
When baseline addict Raphael meet chords maestro Alex, you know right from the start that something special is about to happen. Sprinkle of ass-shaking rhythms blended with UK style grooves and you get The Checkup.
May 12, 2014
Next up on the Electronical Reeds label is Pole Folder, one of the foremost artists in his native Belgium, in association with Simon Latham. They serve up two fantastic tracks that come backed with four equally excellent remixes!
May 12, 2014
La dame Noir Records has impressed with its first 6 EPs and now returns with a 7th from Forty Fings Dynamo – the new side project from Adrien (one half of Villanova) and Emmanuel aka Solofour.
May 12, 2014
Originally from Yorkshire but recently relocated to London, Mella Dee aka Ryan Aitchison is one half of Mista Men but has recently been seeing attention for his solo outings, seeing props from countless DJs as well as the likes of Mixmag and Fact Magazine. Inspired by but not limited to UK Garage and Bassline, Mella Dee's music is gritty throughout and 'Feel it Out' is no different.
April 18, 2014
After two strong releases on Electronical Reeds, the Brussels-based artist Exon Bacon inaugurates Play Label Records with his latest EP, Watching Dogs. Play Label Records is the extension of the collective Play Label that has become a key player in the music scene of Brussels with more than hundreds of events to its credit. This first release sets up the artistic direction of this label that seeks to develop a real dancefloor approach and a strong party spirit.
March 13, 2014
March 12, 2014
For their next release No.19 Music look once again to UK producer Eric Volta, who repeats his 'Master of Puppets' success by further collaborating with vocalist Gretz. The record features three stunning tracks and one reprise, all of which deal in Volta's usual sense of keen synth artistry further enhanced by Gretz's emotive vocal performance.
March 12, 2014
British duo Voyeur will drop the 'Rain Away' EP via Kerri Chandler's Madhouse imprint this March, a three track single of soul drenched house music.
March 12, 2014
Austria's Luv Lite Recordings returns with a new single from sibling pair Sascha & Andi Weisz AKA Weisz² backed with remixes from Scan Mode and Jepe…
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Tuesday night's Giants-Padres game generated a nice baseball beef between the divisional rivals. On a chart of cooking steak, it'd probably register at a "medium." The tiff did involve a thrown piece of gum, however, so that's fun.
Giants catcher Hector Sanchez crushed a grand slam off Padres relief pitcher Dale Thayer for a 9-0 lead in the sixth inning of Tuesday night's game. (Don't let the substantial cheers fool you; the game was played in Petco Park.) Sanchez flipped his bat, and Thayer threw his gum in Sanchez's direction.
Sanchez came up to the plate again in the ninth, while Shawn Kelley was pitching. The catcher grounded out, but exchanged words with Kelley as he walked towards the dugout. The benches cleared, and players from both sides took the opportunity to gesture wildly and dance around.
No punches were thrown; no one was ejected. The hullabaloo marks the second time this season where a Giants-Padres dispute involved a thrown piece of gum.
H/t to Travis
Contact the author at firstname.lastname@example.com.


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Franklin Pierce University
Location Rindge, NH
School Type Private
GMAT Required No
On Campus Requirement No
Est. Tuition $25,545
Est. Cost Per Credit $655
Min. Credit Hours 39
Min. Program Length 12 Months
Accreditation IACBE
Student Population 2,273
Campus Setting Rural: Fringe
Receiving Financial Aid 89%
Student to Faculty Ratio 13 to 1
- Energy And Sustainability
- Healthcare Administration
- Human Resources Management
- Information Technology
- Leadership
- Sports Management


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Why are you selling your services if they work for you ?
For the same reason a lawyer sells his services.
How have you learned trading ?
Yes, I paid 8000 usd in 2011 to learn from professional traders in Paris, France.
Are you or will you make money solely from providing your services ?
No, I have multiple streams of income.
What is the minimum recommended capital to trade with ?
You can start with $1000 but $5000 is better.
Any requirements ?
A good computer like a core i5 boosted [i7 would be better] or alike and windows OS. at least 17 inches screen preferred because you will need to look at several windows if you decide to purchase the program.
When did this group started ?
In May 2019.
Can I do it even if I work ?
Yes, as long as you have time to check the market and messages between London open and USA session every 45 minutes because you can trade from your phone or a tablet that you connect [Via teamviewer] to your computer which would be turned on at your home. There is no predicting as to when the market will move, you might wake up if you live in the USA when the trading is over, or it might be good. Usually 50-50.
Additional tips about money :
I do not personally endorse this but this is what I would do if I had not enough cash on hands but the means to get a loan.
I would make sure this program is good for me, then buy it if convinced and trade using a loan [from 2k to 5k for example to reduce risk] because you could start to pay back the loan with the money you make and if you can't make it work for any reason, stop when you loose 25% of your borrowed capital - because you should not loose more than this - and you should be able to refund 25% of a 2k to 5k loan [which would be max 1.5k]. Sometimes leverage is needed. I know of professional traders that have done it for way more money.


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Hello! I took a bit of an unexpected blogging break this summer – nothing planned and nothing is wrong. I just got busy and realized I needed to give myself a break from worry over it and maybe get back my blogging mojo. So, I thought I'd at least check in and let you know … Read more
So, Friday was my birthday and my oldest friend (meaning longest term, NOT OLDest, lol) took me to the Downton Abbey Exhibition currently showing in Boston and then out to a lovely lunch. I was really looking forward to the exhibit as I loved the series and had extensively blogged about it when it was … Read more
We're coming to an end of my 2019 Newburyport Kitchen Tour coverage. In Part 1 I showed you two large modern black and white houses and in Pt. 2 I shared three mid-sized stylish homes. Now, I've got something special to share – especially if you're a lover of outdoor spaces, beautiful landscaping, water views … Read more
Ready for some mid-size stylish kitchens? In my first post on the 2019 Newburyport Kitchen Tour, I showcased two larger kitchen spaces. Today, I'm sharing three houses which are smaller in scale, but certainly no less in style. Christopher Street Architect: David Keery Design | Interior Design: Holly Gagne Interior Design This cheery yellow … Read more
One of my favorite design tours was this weekend – the Newburyport Kitchen Tour, put on in support of the Newburyport PTO. I've attended several times before and I'm always happy to see what's new in my favorite area of Massachusetts. It was a beautiful day on Saturday – sunny but not too hot or … Read more
I'm excited as one of my favorite annual events is happening this week – The Newburyport Kitchen Tour 2019! Here are some of my pics from prior year's tours. You can read all my posts of previous tours here. The fun thing about this tour is that we're treated to not just kitchens, but often … Read more
It's time for the Spring 2019 Design Books releases (okay, past time!) and I wanted to share a few of my favorites. Preeminent American designer Jeff Bilhuber 's latest book Everyday Decorating, written with Jacqueline Terrebonne, published by Rizzoli 2019, breaks down decorating in the following categories: Comfortable, Happy, Colorful, Personal, Lighter & Brighter, Sexy, … Read more
It's kind of late in the day on Tuesday and it's been a while since I've done a Travel Tuesday post, but wanted to share three places I've just learned about that exude both old world hospitality and modern luxury. The Jane Hotel – New York City I was introduced to The Jane Hotel in … Read more
Today, for purely selfish reasons, I am sharing this amazing pink Palm Beach mansion that was featured in Veranda magazine in February 2019. Why selfish? Because, I just adore pink and green as well as antique homes and my entire Nook Cottage is in this color palette. Also, it's Friday and since I used to … Read more
There's a strong trend these days for folks – from millennials to empty nesters – to want to experience urban city living environments. There's a lot of building in the city going on – especially here in Boston. Millennials are looking to avoid what they see as their parents heavy burdens of the big house … Read more


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Hydrogen Spectroscopy
In our group we concentrate on development of spectroscopic techniques that allow us to gain insight into the interplay between electronic, optical, magnetic and chemical properties of matter. The current areas of expertise include, but are not limited to, table-top ambient pressure XPS for studying metallic and organic membranes exposed to hydrogen and other gasses, deep UV Raman spectroscopy for detection of trace-pollutants in liquid environment, air lasing as remote environmental sensor and magneto-optical Faraday and Kerr effect set-up for analysis of photo- and electrochemically induced electronic structures of water splitting catalysts. Moreover, we make use of our state-of-the-art facilities equipped with the commercially available Raman, IR, UV-Vis spectrometers and other analytical methods for bridging analytical problems to the existing methods, establishing collaborations and proving consulting for academia and industry. The element in focus is hydrogen as its analysis faces specific challenges. Here, we collaborate with a number of large research facilities (PSI-SINQ, RAL-ISIS, ORNL-SNS) providing neutrons as a selective probe for hydrogen in matter.
Ongoing projects
Chemical analysis of CO2 reduction
We utilize a variety of special analysis tools to characterize processes generating fuel from CO2 and hydrogen. For more information please see here. Recent highlights are the develop-ment and utilization of neutron imaging to observe the CO2 reduction in real-time in collabo-ration with the Laboratory for Neutron Scattering and Imaging at PSI. The movie below shows the diffusion of water into mm-sized zeolite beads. Further fascinating results are found in the recent publication in Journal Physical Chemistry. The video shows a H2O absorption experiments into mm-sized zeolite beads, visualized using neutron imaging. Image size is 4x5 mm2, time step is 1 min per image.
LightCheC project in collaboration with the University of Zurich:
"Laser membrane photoemission and magneto-optical spectroscopy shining light on solar water splitting" (see also https://www.empa.ch/web/s502/catalytic-methanation) We are heading for a comprehensive understanding of the electronic structure and its dynamics of materials for solar water splitting. The work may be divided into two parts: the investigation of homo-geneous and heterogeneous solar water splitting by time resolved magneto-optical spectroscopy (trMOKE) and by laser-induces photoemission. For the latter, we are developing a pulsed laser-driven plasma UV source and membrane-based tabletop photoemission set-up. Thus, the method provides information on in-situ probing of the electronic changes in the catalyst over the course of the reaction and offers an alternative to the expensive and often inaccessible synchrotron sources. The magnetic properties of materials are very sensitive to the electronic properties and thus serve as a probe for the changes induced by light and adjacent chemical processes in photocatalytic reactions. Thus, we take advantage of the trMOKE approach for studying magnetic and optical properties of homogeneous and heterogeneous systems in transmission and reflection geometries. Apart from empirical investigations, we model the obtained data using the established models for anticipating the activity of catalytic sur-faces (e.g., the Norskov model). We are aiming at extending these models by the time dimension as needed in photo-catalysis.
BAFU-project: deepUV-Raman for water analysis
An alternative online technique to perform quantitative analysis and detection is missing. Raman spec-troscopy is one of the most promising spectroscopic techniques for such purpose, because it offers a chemically selective online analysis of most common organic pollutants. However, its maximum sensi-tivity is limited to 100 mg/l. Different factors restrict its limit of detection (LOD). The majors are the low Raman scattering cross section (intrinsic low efficiency of the Raman scattering process), the overlap of the weak Raman signal by strong fluorescence emission, and the absorption in liquid environments. Excitation and measurement of Raman spectra below 260 nm (deepUV) is not hindered by fluorescence and has markedly higher cross sections than common Raman spectrometer working in the visible. Within this joined project with rascope ag, which is financed by the BAFU, we develop a prototype of a deepUV-Raman spectrometer as cost-competitive water analysis device.
Sambalova, O., Thorwarth, K., Heeb, N.V., Bleiner, D., Zhang, Y., Borgschulte, A., Kroll, A. Carboxylate Functional Groups Mediate Interaction with Silver Nanoparticles in Biofilm Matrix (2017) ACS Omega, 3 (1), pp. 724-733. DOI: 10.1021/acsomega.7b00982


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A row has emerged between the National Forestry Authority (NFA) and Mpanga Secondary School in Fort Portal Municipality over a piece of land estimated to be over 0.4 hectares. NFA claims the land belongs to it.
A row has emerged between the National Forestry Authority (NFA) and Mpanga Secondary School in Fort Portal Municipality over a piece of land estimated to be over 0.4 hectares. NFA claims the land belongs to it.
The school, that was started in the 1960s, wants to construct classroom blocks and laboratories to accommodate the increasing number of students, especially those under the Universal Secondary Education (USE) programme, but these plans have been frustrated by NFA claims that the land is a forest reserve.
"The school will pull out of the USE programme. We cannot handle the large number of students since we have no land for expansion,†said the headmaster, Turyaguma Baramu.
The school has 1,462 students, of which 509 are admitted under the USE programme, paying sh29,420 per term.
Most of the students come from the neighbouring districts of Kyenjojo, Kamwenge, Bundibugyo and Kasese.
Currently, the school has 19 classrooms on the O'Level block and five on the A'Level block. It also has two laboratories and a library that can accommodate 200 students.
The school recently received a sh900m grant from the African Development Bank to construct a laboratory. Construction is expected to start next month.
Fort Portal Municipality MP, Stephen Kaliba recently led MPs environmental minister Jessica Eriyo and lands state minister Atwooki Kasirivu to the school to study the situation.
Baramu said the school acquired ownership of the land through the Uganda Lands Commission.
"We want the Government to intervene. When NFA tried to challenge us on the ownership of the land, we wrote to the Solicitor General, who made it clear the land is ours,†Baramu said.
He said the Prime Minister, Professor Apolo Nsibambi, recently said that if NFA felt strongly about the land, they should compensate the school and give it alternative land.
Nsibambi also directed that NFA should stop its evictions and gave a go-ahead for the school to construct classroom blocks on the land.
However, the headmaster said when they started grading the land, Samwiri Rwabwogo, NFA's law enforcement coordinator, led a group of armed men who beat the driver of the grader.
Rwabwogo said the school was advised to get an occupational permit to allow them use the forest reserve, but they did not heed.
"If they wanted the land, there are procedures to follow based on the Land Act,†Rwabwogo said.
He said they would not give the school alternative land because it is a forest reserve.
Rwabwogo said NFA would turn the area into a green park and a recreation centre for children.
Asked if the school can co-exist with the surrounding forest reserve, the district environment officer, Alex Winyi, said the environment ministry should first issue a licence to degazete the forest reserve.
"If the land has been degazetted, it can be reverted to the district land board, where the school can apply for the land,†Winyi said.
He said the land board or the school should look for alternative land to swap with the forest reserve. The alternative land should be equal or higher in value to the existing forest reserve and an Environment Impact Assessment should first be carried out.
The parents' representative, Silvester Kimara, said: "If NFA insists that the forest reserve is theirs, then the school will not admit more students under the USE programme.
The students' leaders say it is unfortunate that the school and NFA are engaged in unnecessary conflicts. "We are perturbed that the Government institutions are fighting each other and wasting time.
NFA is frustrating the USE programme,†said Edwin Businge, the school headboy.
Businge said NFA stopped the construction of teachers' houses, yet many of them live far away from the school.
"Because of that, teachers cannot teach until late,†Businge said.
The students said if the school is to be relocated, NFA should consider the distance that they (students) will have to cover.
Hamisi Kapande, the chairman of the school council, said NFA should allow the school to expand so that it carries out co-curricular activities.
He said students have to move to Buhinga and Boma playgrounds for sports.
Mpanga School, National Forestry Authority in row over land


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12 Tips for Improving Your Web Design
Your website is the first interaction potential customers have with your brand. It can affect how people feel about your brand and how they interact with it. More importantly, it can be a crucial determinant of conversion rate, return visits, and referral rate.
It is no surprise then that improving website design is something most businesses look into frequently. However, not all companies may need to improve their website design.
So, before you get into the twelve tips on how to improve website design effectively, I implore you to ask yourselves these questions:
If you answered 'no' to more than one of these questions, your website is in desperate need for an improved design, and here are some tips you can use:
Twelve Tips to an Improved Web Design
1) Use White Space
Let's start from the simplest tip; using white space in your web design. This is one of those fundamental principles they teach graphic designers, but you would be surprised by the number of designers who don't implement them when building a client's site.
White space is the space on your website where there isn't any design, text, image, etc. It is the space around the content on your website. This space is significant because it makes your site look more appealing and put together, allowing users to focus on more important things.
Some studies have shown that white space around website content increases user's attention by 20%.
2) Improve Your Call-To-Action
Another tip from our website design tips list is to improve your call-to-action. Every website should have a purpose, a goal you are trying to achieve with certain aspects/pages on your website, and you should enhance that goal with CTA.
Improving your web design with call-to-actions (CTAs) is critical for improving website design. CTA could be in the form of action buttons, contact forms, etc. Whatever method you decide to call your users to action, make sure your CTA is visually appealing to your target audience, and extremely clear on the action you want them to perform.
3) Check for 404 Errors or Broken Links
There is nothing more annoying for users than a broken link on a web page. If I were to go on a website and get a 404 error, I would think the owners of the site weren't taking their website seriously. 404 errors aren't just annoying; they also make your website run slow and negatively affect your ranking on search engines.
But how do you check for broken links? Luckily for you, there are numerous free tools out there that you can use to check for 404 errors and broken links. Do your research on the tools out there, pick the ones that work with your needs, run them to identify whatever problem area, and fix the issues immediately.
4) Increase Website Loading Speed
A fast loading website can positively affect the amount of time visitors spend on your site. There have even been studies carried out to this effect. Optimizing your website load time means that you remove things on your website that make it load slower, therefore increasing load speed and simultaneously increasing customer satisfaction. Below is a checklist to follow when optimizing load time:
5) Make Your Navigation Clear
Imagine visiting a website and spending a long time looking for pages; it would annoy and frustrate you, wouldn't it? If customers complain that your contact details are not immediately visible on your website, or that they can't access your blog or shop page, then you know that your navigation needs work.
Whatever industry you find yourself in, make sure that visitors on your website can easily access all the products/services your company has to offer. Organize your site's navigation bar, so only the necessary things are there. Visitors should immediately see the different sections of your website from your navigation bar, so they aren't wasting time roaming through your site.
6) Make Sure Your Website is Mobile-Friendly
Do you know how many internet users own a smartphone? More than 80%! So why isn't your website already optimized for mobile devices?
Even Google changed its search algorithm to ensure that mobile-optimized websites with a fast loading speed get a higher ranking in search engines than those websites not optimized for mobile.
Some tools help users check the load time of their website on mobile. Make sure you use them to test your website's mobile responsiveness and fix the issues that need fixing in a bid to get the most optimized mobile site.
7) Include 'Share' Button on Your Site
We decided to add this tip to our website design tips because it not only enhances the experience users have on your website, a share button also acts as a form of promotion for your website.
Adding a share button on your site encourages people to share your website on social media. So, you have visitors who like your website, sharing it with their social circle, thus increasing your website visibility.
Some of the best website designing help guides have website builders they recommend who have sharing buttons as a tool you can construct on your website.
8) Improve your SEO
Search engine optimization is an essential tip on our list of website design tips. With a search engine optimized website, you know that your intended target audience will always find you.
However, search engine optimization is not the simplest thing to do, so some businesses run away from it. Still, with these few essential tips, you can start your SEO for your website;
9) Have a Responsive Site
Having a responsive site is probably one of those things most website admins ignore, and they find out too late how important it is. Let me give you an example; imagine I am a customer, and I frequent your site often, share your content with my circle, and I'm continually buying products from your website, but there's nowhere for me to leave my feedback or comments. How do you think that would make me feel?
No doubt, customers who find that websites don't have feedback/comment sections on their website must feel that there is no way to communicate with them.
A feedback/comment section on your website isn't only for the benefit of the customer though, with a comment section, companies can engage with their existing customers, promoting loyalty.
10) Create a Customer Persona and Create Content For Them
With this, I simply mean meeting your intended audience at eye level. Explain to them how you can solve their problems with your product/service. Or how your product could bring relevance to their lives.
It's all about restructuring your grammar, so it's for them, and not to toot your own horn. For example, instead of having a page called 'case studies, ' switch it up to 'success stories.'
11) Make your Home Page Scrollable
You may have heard about the above the fold website design. Well, in 2020, do away with it. It is an old way of designing your website, and keeping with the trend in your website design is vital.
Design slightly longer homepages, with different sections that you want to highlight to your customers. The parts could cover your product features, company introduction, or even testimonials. It all depends on what you think your users want to see instantly, and the content you require most visible to them.
12) Never Stop Testing
Just as growth never stops, so does testing. If you want to improve your web design, you need to test your website continually. You can do this by subscribing to any web analytics tool out there.
Final Thoughts
Simplicity is the ultimate key to these website design tips I shared. Only put relevant content on your website, and you will find your site already ticking all the boxes from the tips above. However, if you need further website designing help, or you need content created on your website, writing review service reviews such as Best Writers Online Is an excellent place to get help
- 12 Tips for Improving Your Web Design - May 24, 2020


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The average conversion rate for websites is slightly over 2%. So only about 2% of website visitors convert when they visit websites. Through the results of our recruiting lead generation… read more →
Heavy-duty commercial trucks can be very expensive. The initial purchase can be upwards of $120,000. Then there is the cost associated with merely operating the vehicle and keeping it properly… read more →


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A most advanced genetic testing service to be introduced to The Gulf Region.
Eastern Biotech and Life Sciences is a medical diagnostic services company based in Dubai, established in 2005 and has been at the forefront of Diagnostic healthcare in the region. The company was established to bring a paradigm shift in the diagnostic industry throughout the MENA region through pioneering technologies and excellent customer service.
Genoplan is an ISO accredited product that analyses 700,000 markers through a simple saliva sample. A detailed analysis of one's DNA can identify the genetic information that make you who you are through this technology. The test report can help you discover more about your health, traits and any predisposition and provides a comprehensive 460+ personalized report.
"Since our inception, it's been our mission to ensure more targeted approaches to deliver high accuracy, affordable and rapid medical and health testing," said Dr. Faruq Badiuddin, Managing Director. "The Genoplan test will provide a full overview of the clients health and well-being detailed in a wide-ranging report that's focused purely on them. It gives details of your genetic predisposition to 26 Cancers, over 100 Metabolic, Circulatory and Mental disorders, your variable response to commonly used drugs, and many more genetic traits including those influencing your fitness and nutrition. We've worked diligently to ensure that our exclusive laboratory collaboration for the GCC region is another step towards that continued focus. We're excited to continue with a new and exciting service that complements our product portfolio and effectively meets the needs of both clients' and partners."


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We Create Better Future
The Ram chandra singh memorial degree college offers opportunities for all pupils to achieve excellence
in academic, cultural, artistic, sporting, social justice and community endeavours. We provide an
inclusive, caring environment which fosters collaborative learning and positive relationships.
We do exhort our pupils to drive themselves towards personal best performance,
but remind them always that achievement must be framed by procedural limits and ethical boundaries. Knowledge
economy people need cutting edge competencies, imagination, fast reactions and a strong competitive streak.
We focus on building these capacities and attributes in our students
We value collaborative learning, positive relationships and building capacity
amongst our pupils to effectively allow them to engage in the world of the future, where problem solving,
evaluating, working in teams, communicating, creating and innovating are not only valued concepts, but
expected skills, attributes and capabilities. Manager/Secretary : Mr.K.P. Singh Yadav
To quote former President of India Mr. Abdul Kalam "All Birds find
shelter during a rain. But Eagle avoids rain by flying above the Clouds."


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I have been very pleased with the consistent quality of work that we get from Alpha Graphics. I was on a time crunch and you were able to help me meet my deadlines with a quick turn around time that did not compromise quality. I look forward to bringing more projects to Alpha Graphics in the near future.
Stephanie R.
Experience was utterly perfect. I submitted my image online and was then contacted by a representative to finalize my order and offer any recommendations that would result in the best print. Alphagraphics took care of everything from there. I was contacted when my order was ready (ahead of schedule) and the prints could not have come out better. Beautiful work, simple process, with very reasonable prices.
Jen H.
Transform your company car or truck into a rolling billboard for your brand with custom vehicle wraps and graphics. From full body wraps, to magnets, and everything in between, AlphaGraphics has the tools to turn your boring delivery van into an eye-catching advertisement on wheels!
What better way to multi-task than by advertising your products and services while you're stuck in traffic? Vehicle wraps allow you to effortlessly reach thousands of wandering eyes with your brand message during your daily commute. With so many options to choose from, our marketing and communications experts can help you hand-craft the ideal wrap to knock your branding objectives out of the park.
Not quite ready for the full wrap effect? No problem. We offer a variety of lower-profile vehicle graphic options.
- Window perforations
- Frosted graphics
- Window clings
- Custom vehicle lettering
- Vehicle magnets
- Partial vehicle wraps
Not only can our team help you develop your messaging and design, but we'll print, laminate, cut and install your wrap or graphics for you. Choose from unique materials like matte, chrome and other specialty vinyl; and rest assured that our advanced printing technologies will convert your static design into a vibrant, full-color statement for your vehicle.
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Let AlphaGraphics Somerset County help with your cusomer vehicle wrap. Have you ever noticed while driving around town the cars that have advertising wrapped aroundthem? Whether it's on a plumbers truck, a garage door repair truck, or a food catering van, your attention is immediately drawn to it. What better way to get your company's name spread around the community that by creating car graphics, decals and wraps to use on company vehicles.
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Shameless renewed by Showtime for ninth season
Following the eighth season premiere of the series on Sunday, Showtime has renewed its hit series Shameless for a ninth season. The Season 8 premiere of the show delivered a 50 percent year-over-year growth for the series. Production on season nine of Shameless will begin in 2018.
"As challenging as it can be for any show simply to maintain viewers in the current TV landscape, Shameless is adding them in droves," said David Nevins, President and CEO, Showtime Networks Inc. "But it's no mystery why. The series' reputation for rich and resonant characters and for deep – and deeply twisted – comedy has drawn not only faithful longtime viewers, but a steadily growing audience. And creatively, the season that kicked off this past Sunday is stronger than ever."
"We are so grateful to Showtime for giving us the opportunity to continue making Shameless," said series executive producer and showrunner John Wells. "It's a labor of love (and a blast) for all of us."
One of the network's longest-running and most successful series ever, Shameless ranks as the network's No. 1 comedy and attracts the youngest-skewing audience of any Showtime series. Shameless had its biggest season yet last fall with 6.5 million viewers tuning in each week. The series returned this past Sunday with its highest-rated premiere since its third season and up 50 percent versus the season seven premiere.
Shameless stars Oscar nominee and Emmy and SAG Award winner William H. Macy and Golden Globe nominee Emmy Rossum. Created by Paul Abbott, Shameless is produced by Bonanza Productions in association with John Wells Productions and Warner Bros. Television. Developed for American television by John Wells, the series is executive produced by Wells, Nancy M. Pimental and Sheila Callaghan.


text:
Running a file other than the main file for Unit Testing
I created a test_main.py file to unit test the main.py file. But every time I click "Run", it only runs the main.py file. Is it possible to run a file other than the main file?
You are viewing a single comment. View All
fandressouza (5)
In case someone is looking to simply run a file use:
import os
os.system('python3 <filename>.py')
m201713 (0)
how did you do that?
if i click the run icon, it show me like this
sh: 1: cannot open Ex01: No such file
fandressouza (5)
@m201713 make sure you remove "<>", if your file is called second.py you must write the following:
import os
os.system('python3 second.py')


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10-minute Cream Cheese Spaghetti
The cream cheese sauce is embarrassingly smooth to make, but it turns your plain pasta dish into something top.
Mix garlic-infused olive oil, creamy cheese, savory parmesan, and delicious spaghetti. Then add freshly ground pepper or an amazing pinch of chili flakes, and a further drizzle of olive oil to enhance the taste!
This changed into one of my pass-to recipes once I changed into at uni, and it changed into so popular with my flatmates!
- 1/2 lb (225 grams) pasta (spaghetti, penne, fusilli…)
- 3/4 cup (150 grams) cream cheese*
- 1/4 cup (30 grams) grated parmesan, plus more to serve
- 1 Tbsp olive oil, plus more to serve
- 1-2 garlic cloves, minced or pressed
- 1/2 cup (120 ml) cooking water, plus more if needed
- salt and pepper, to taste
- 1/4-1/2 tsp chili flakes, or according to taste (optional)
In a large pot of boiling salted water, cook pasta according to package directions until al dente.
Right before draining, reserve a cup of starchy pasta water.
In meanwhile, in a large skillet warm 1 Tbsp of olive oil and gently fry the garlic (plus a good pinch of chili flakes if you like) for 2-3 minutes. Use a low flame, do not let the garlic burn.
Then stir the cream cheese and about 1/2 cup of starchy pasta water. Stir to combine oil, cream cheese, water and create a nice and creamy emulsion. Your pasta sauce is ready.
Drain and add your pasta to the skillet. Stir well to evenly coat the pasta in the sauce, add parmesan and more cooking water as needed for a smooth and creamy consistency.
Serve immediately with a drizzle of good olive oil or extra virgin olive oil, freshly grated parmesan, and freshly ground black pepper (if you don't use chili flakes). Enjoy!
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If anyone was tuning in to the Democratic debate hoping to see a Mortal Combat-style throw down between Bernie Sanders and Hillary Clinton on Saturday night—they would have been disappointed.
That sad group includes Martin O'Malley.
But the debate did draw stark contrasts and testy exchanges between the two Democratic frontrunners on critical issues like foreign policy and financial ties to Wall Street that may turn the heads—and possibly the votes of Democratic voters.
The first question of the debate dealt with the scandal that broke early Friday about how a Bernie Sanders staffer used a momentary lapse in a voter database firewall to poach/or peruse (depending on which camp you speak to) critical campaign information from the Clinton campaign. The breach of the Democratic National Committee's database added intrigue to a debate that felt obligatory compared to the fiery contests between Republicans, but instead of sparking a brawl, it was quickly extinguished in the first few minutes of the debate.
Sanders apologized to Clinton for his staffer's decision to take advantage of a down firewall to go through Clinton's proprietary campaign data, an apology she immediately accepted.
"Obviously we were distressed when we learned of it, because we've worked very hard," Clinton said. "And so now that I think that we've resolved your data, agreed on an independent inquiry, we should move on. Because I don't think the American people care all that much."
O'Malley, who was also at the debate, had practiced a line about bickering and was not about to let it go. Even though there wasn't any bickering … or real disagreement.
"[F]or crying out loud, our country has been attacked, we have pressing issues involving how we're going to adapt to this changing era of warfare," O'Malley started. "Instead, we're listening to the bickering back and forth. Maybe that is normal politics in Washington, but that is not the politics of higher purpose that people expect from our party."
That's not to say the two Democratic frontrunners did not have crucial policy differences and the debate did get testy at times.
Some of the more heated exchanges between Sanders and Clinton were on Wall Street and the influence of corporate America, where the two diverge dramatically.
"Should corporate America love Hillary Clinton?" moderator David Muir asked.
"Everybody should," Clinton responded, as the debate hall laughed.
"I want to make sure the wealthy pay their fair share, which they have not been doing," she said, and then reiterated her support for the Buffet rule that would require millionaires to pay higher tax rates.
But when Sanders was asked the same question, he responded, "No, I think they won't."
"So Hillary and I have a difference. The CEOs of large multinationals may like Hillary," Sanders said. "They ain't going to like me and Wall Street is going to like me even less."
Sanders then launched in his list of reforms including re-establishing the Glass-Steagall Act of 1933.
"We have got to break the large financial institutions up," he said.
The two also butted heads twice on the issue of regime change in Syria and Clinton was put on the defensive about her push to overthrow Muammar Gaddafi that threw the country into chaos.
"I am not giving up on Libya and no one should," Clinton said.
Sanders, who repeatedly touted his vote against the Iraq war—a not so subtle dig at Clinton who voted for it—criticized Clinton as "too much into regime change and too aggressive without knowing what the consequences may be."
Clinton shot back, "With all due respect, Senator, you voted for regime change with respect to Libya. You joined the Senate in voting to get rid of Gaddafi, and you asked that there be a Security Council validation of that with a resolution."
On Syria, Sanders said that ISIS should be the first priority in terms of dealing with a threat on American soil; Clinton said you couldn't defeat ISIS without dealing with Assad.
"I wish it could be either/or. I wish we could say yes, let's go destroy ISIS and let's let Assad continue to destroy Syria, which creates more terrorists, more extremists by the minute," she said. "No. We now finally are where we need to be. We have a strategy and a commitment to go after ISIS, which is a danger to us as well as the region."
Only one member of the Republican field was mentioned during the two-hour debate. And that was—you guessed it—Donald Trump.
Trump was unanimously condemned for his bigoted rhetoric on Mexicans and Muslims.
Clinton expressed worry that Trump "is sending a message to Muslims here in the United States and literally around the world that there is a 'clash of civilizations,' that there is some kind of Western plot or even 'war against Islam,' which then I believe fans the flames of radicalization."
She also alleged he was being used as a recruiting tool for ISIS.
Sanders sought to remind Trump voters that Trump didn't have their interest at heart when it came to creating jobs.
"[S]omebody like a Trump comes along and says, 'I know the answers. The answer is that all of the Mexicans, they're criminals and rapists, we've got to hate the Mexicans. Those are your enemies,'" he said. "'We hate all the Muslims, because all of the Muslims are terrorists. We've got to hate the Muslims.' Meanwhile, the rich get richer."
Speaking of Trump, the substance-laden debate—punctuated with moments of O'Malley—was a stark reminder of why Trump has become such a phenomenon this cycle: He makes these exercises in democracy entertaining, for better or for worse.


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New Rule for Calculating OVERTIME for Fluctuating Workweeks
We all know (or learn) that not everything in life can be carefully planned. For example, some weeks an employer may need a worker for just 30 hours, but in another week may need them to put in 50 hours. The Fair Labor Standards Act (FLSA) has long provided employers with the option to pay nonexempt employees whose hours vary on a salary basis, but at times has offered inconsistent guidance on the impact of bonuses and commissions, or how to calculate overtime. When courts got involved, sometimes there were conflicting rulings.
Under Secretary Scalia's leadership, the U.S. Department of Labor (DOL) is offering some clarification. On May 20, 2020, DOL announced a Final Rule https://www.dol.gov/sites/dolgov/files/WHD/fww/FR-FWW.pdf that clarifies that employers may pay bonuses or other incentive-based pay to salaried, nonexempt employees whose hours vary week-to-week. The Final Rule applies to employees who meet the following criteria:
(1) the employee's hours fluctuate from week to week;
(2) the employee receives a guaranteed salary that does not vary with the number of hours worked (docking employees in "short weeks" is fatal);
(3) the amount of the employee's fixed salary is at least equal to minimum wage for every hour worked;
(4) the employee and the employer have a clear and mutual understanding about the manner of pay; and
(5) the employee receives overtime pay, in addition to salary and any bonuses, for all overtime hours worked.
Note that in this scenario the employer pays an overtime premium of one-half - not one-and-a-half - times the regular hourly rate for each overtime hour. Assuming a worker is paid $400/week for all hours, and works 50 hours and also gets a $50 bonus, pay should be the base salary ($400) plus $50 bonus ($450), divided by the total number of hours worked (50), for a 'regular rate" of $9/hour; plus $4.50 (one-half of $9) per overtime hour, yielding a total paycheck of $495 (base $400 + bonus $50 + 10 hours OT premium = $45).
In addition to changing the title of the regulation from "Fixed salary for fluctuating hours" to "Fluctuating Workweek Method of Computing Overtime," the Final Rule achieves the following:
- Expressly states that employers can pay bonuses, premiums, or other additional pay, such as commissions and hazard pay, to nonexempt employees compensated on a salary basis using the fluctuating workweek method. (See 29 CFR 778.114(a).) These supplemental payments must be included in calculating the employee's "regular rate" (for purposes of overtime) unless they are excluded under other provisions of the FLSA. This allows employers greater flexibility to provide bonuses or other additional compensation to nonexempt employees whose hours vary from week to week and eliminates any disincentive for employers to make supplemental payments.
- Illustrates how an employer may pay an employee a shift differential or productivity bonus in compliance with the rules. (See examples in 29 CFR 778.114(b).) This may be particularly valuable guidance for employers who want to reward their workers with more pay for their efforts in dealing with the COVID19 crisis.
- Clarifies confusing language to make the fluctuating workweek method easier to understand and administer. (See revised 29 CFR 778.114(a).)
There are several other things to understand about the Final Rule. First, it is not strictly speaking a regulation, but rather a statement of general policy and official interpretation. This affects the degree of deference a court will give it. Regulations have more authority than interpretations; this is an interpretation, and some courts may be less willing to find it binding. Second, there are some surprising omissions. For example, if a nonexempt employee's hours don't vary weekly, but are regularly scheduled; and the employer wants to pay a guaranteed salary for all hours worked, it's not clear that the rule would apply.
The new Final Rule also addresses divergent views that have been expressed by DOL and courts in the past, with a view to eliminating legal uncertainty for employers regarding the compatibility of various types of supplemental pay with the fluctuating workweek method, which can generate significant savings in overtime. In sum, the new rule provides employers concrete guidance to ensure compliance - and avoid punishing employers who give workers extra pay, as the old rules sometimes were interpreted to do.


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Programmed cell death protein 1
PD-1 inhibitors, a new class of drugs that block PD-1, activate the immune system to attack tumors and are used to treat certain types of cancer.[5][8]
The PD-1 protein in humans is encoded by the PDCD1 gene.[9][10] PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells.[10] PD-1 binds two ligands, PD-L1and PD-L2.
In a screen for genes involved in apoptosis, Yasumasa Ishida, Tasuku Honjo and colleagues at Kyoto Universityin 1992 discovered and named PD-1.[11][12] In 1999, the same group demonstrated that mice where PD-1 was knocked down were prone to autoimmune disease and hence concluded that PD-1 was a negative regulator of immune responses.[12]
PD-1 is a type I membrane protein of 268 amino acids. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators.[11] The protein's structure includes an extracellular IgV domain followed by a transmembraneregion and an intracellular tail. The intracellular tail contains two phosphorylation sites located in an immunoreceptor tyrosine-based inhibitory motif and an immunoreceptor tyrosine-based switch motif, which suggests that PD-1 negatively regulates T-cell receptor TCR signals.[11][13] This is consistent with binding of SHP-1 and SHP-2 phosphatases to the cytoplasmic tail of PD-1 upon ligand binding. In addition, PD-1 ligation up-regulates E3-ubiquitin ligases CBL-b and c-CBL that trigger T cell receptor down-modulation.[14] PD-1 is expressed on the surface of activated T cells, B cells, and macrophages,[15] suggesting that compared to CTLA-4, PD-1 more broadly negatively regulates immune responses.
PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family.[16][17] PD-L1 protein is upregulated on macrophages and dendritic cells (DC) in response to LPS and GM-CSF treatment, and on T cells and B cells upon TCR and B cell receptor signaling, whereas in resting mice, PD-L1 mRNA can be detected in the heart, lung, thymus, spleen, and kidney.[16][18] PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ.[19][20] PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines.[17]
Several lines of evidence suggest that PD-1 and its ligands negatively regulate immune responses. PD-1 knockout mice have been shown to develop lupus-like glomerulonephritis and dilated cardiomyopathy on the C57BL/6 and BALB/c backgrounds, respectively.[21][22] In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion.[16] IFN-γ is a key pro-inflammatory cytokine that promotes T cell inflammatory activity. Reduced T cell proliferation was also correlated with attenuated IL-2 secretion and together, these data suggest that PD-1 negatively regulates T cell responses.[23]
Experiments using PD-L1 transfected DCs and PD-1 expressing transgenic (Tg) CD4+ and CD8+ T cells suggest that CD8+ T cells are more susceptible to inhibition by PD-L1, although this could be dependent on the strength of TCR signaling. Consistent with a role in negatively regulating CD8+ T cell responses, using an LCMV viral vector model of chronic infection, Rafi Ahmed's group showed that the PD-1-PD-L1 interaction inhibits activation, expansion and acquisition of effector functions of virus specific CD8+ T cells, which can be reversed by blocking the PD-1-PD-L1 interaction.[24]
Expression of PD-L1 on tumor cells inhibits anti-tumor activity through engagement of PD-1 on effector T cells.[19][20] Expression of PD-L1 on tumors is correlated with reduced survival in esophageal, pancreatic and other types of cancers, highlighting this pathway as a target for immunotherapy.[5][25] Triggering PD-1, expressed on monocytes and up-regulated upon monocytes activation, by its ligand PD-L1 induces IL-10 production which inhibits CD4 T-cell function.[26]
In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.[10]
Overexpression of PD1 on CD8+ T cells is one of the indicators of T-cell exhaustion (e.g. in chronic infection or cancer).[5][27]
Clinical significance[edit]
PD-L1, the ligand for PD1, is highly expressed in several cancers and hence the role of PD1 in cancer immune evasion is well established.[28][29][5] Monoclonal antibodiestargeting PD-1 that boost the immune system are being developed for the treatment of cancer.[5][30] Many tumor cells express PD-L1, an immunosuppressive PD-1 ligand; inhibition of the interaction between PD-1 and PD-L1 can enhance T-cell responses in vitro and mediate preclinical antitumor activity. This is known as immune checkpoint blockade.
Combination therapy using both anti-PD1 along with anti-CTLA4 therapeutics have emerged as important tumor treatments within the field of checkpoint inhibition.
A combination of PD1 and CTLA4 antibodies has been shown to be more effective than either antibody alone in the treatment of a variety of cancers. The effects of the two antibodies do not appear to be redundant.[5][31][32][33] Anti-CTLA4 treatment leads to an enhanced antigen specific T cell dependent immune reaction while anti-PD-1 appears to reactivate CD8+ T cells ability to lyse cancer cells.[5][34][35]
In clinical trials, combination therapy has been shown to be effective in reducing tumor size in patients that are unresponsive to single co-inhibitory blockade, despite increasing levels of toxicity due to anti-CTLA4 treatment.[36] A combination of PD1 and CTLA4 induced up to a ten-fold higher number of CD8+ T cells that are actively infiltrating the tumor tissue.[34] The authors hypothesized that the higher levels of CD8+ T cell infiltration was due to anti-CTLA-4 inhibited the conversion of CD4 T cells to T regulator cells and further reduced T regulatory suppression with anti-PD-1. This combination promoted a more robust inflammatory response to the tumor that reduced the size of the cancer. Most recently, the FDA has approved a combination therapy with both anti-CTLA4 (ipilimumab) and anti-PD1 (nivolumab) in October 2015.[37]
The molecular factors and receptors necessary making a tumor receptive to anti-PD1 treatment remains unknown. PDL1 expression on the surface on cancer cells plays a significant role. PDL1 positive tumors were twice as likely to respond to combination treatment.[37][36] However patients with PDL1 negative tumors also have limited response to anti-PD1, demonstrating that PDL1 expression is not an absolute determinant of the effectiveness of therapy.[37]
Higher mutational burden in the tumor is correlated with a greater effect of the anti-PD-1 treatment. In clinical trials, patients who benefited from anti-PD1 treatment had cancers, such as melanoma, bladder cancer, and gastric cancer, that had a median higher average number of mutations than the patients who do did not respond to the therapy. However, the correlation between higher tumor burden and the clinical effectiveness of PD-1 immune blockade is still uncertain.[37]
The 2018 Nobel prize for medicine was awarded to James P Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation".
Anti-PD-1 therapeutics[edit]Main article: PD-1 and PD-L1 inhibitors
A number of cancer immunotherapy agents that target the PD-1 receptor have been developed.
One such anti-PD-1 antibody drug, nivolumab, (Opdivo - Bristol-Myers Squibb), produced complete or partial responses in non-small-cell lung cancer, melanoma, and renal-cell cancer, in a clinical trial with a total of 296 patients.[38] Colon and pancreatic cancer did not have a response. Nivolumab (Opdivo, Bristol-Myers Squibb) was approved in Japan in July 2014 and by the US FDA in December 2014 to treat metastatic melanoma.
Pembrolizumab (Keytruda, MK-3475, Merck), which also targets PD-1 receptors, was approved by the FDA in Sept 2014 to treat metastatic melanoma. Pembrolizumab has been made accessible to advanced melanoma patients in the UK via UK Early Access to Medicines Scheme (EAMS) in March 2015. It is being used in clinical trials in the US for lung cancer, lymphoma, and mesothelioma. It has had measured success, with little side effects.[5] It is up to the manufacturer of the drug to submit application to the FDA for approval for use in these diseases. On October 2, 2015 Pembrolizumab was approved by FDA for advanced (metastatic) non-small cell lung cancer (NSCLC) patients whose disease has progressed after other treatments.[39]
Other drugs in early stage development targeting PD-1 receptors (checkpoint inhibitors) are Pidilizumab (CT-011, Cure Tech) and BMS-936559 (Bristol Myers Squibb). Both Atezolizumab (MPDL3280A, Roche) and Avelumab (Merck KGaA, Darmstadt, Germany & Pfizer) target the similar PD-L1 receptor.
Animal studies[edit]
Drugs targeting PD-1 in combination with other negative immune checkpoint receptors, such as (TIGIT), may augment immune responses and/or facilitate HIVeradication.[40][41] T lymphocytes exhibit elevated expression of PD-1 in cases of chronic HIV infection.[42] Heightened presence of the PD-1 receptors corresponds to exhaustion of the HIV specific CD8+ cytotoxic and CD4+ helper T cell populations that are vital in combating the virus. Immune blockade of PD-1 resulted in restoration of T cell inflammatory phenotype necessary to combat the progression of disease.[42]
Alzheimer's disease[edit]
Blocking of PD-1 leads to a reduction in cerebral amyloid-β plaques and improves cognitive performance in mice.[43] Immune blockade of PD-1 evoked an IFN-γ dependent immune response that recruited monocyte-derived macrophages to the brain that were then capable of clearing the amyloid-β plaques from the tissue. Repeated administrations with anti-PD-1 were found to be necessary to maintain the therapeutic effects of the treatment. Amyloid fibrils are immunosuppressive and this finding has been separately confirmed by examining the effects of the fibrils in neuroinflammatory diseases.[44][45][46] PD-1 counteracts the effects of the fibrils by boosting immune activity and triggering an immune pathway that allows for brain repair.[43]
Source: https://en.wikipedia.org/wiki/Programmed_cell_death_protein_1


text:
Admittedly, the death of a dog is not equivalent to the loss of a child or other family member. Yet it does present a similar challenge to integrate the reality of death into a life that, in its totality, is hopefully creative and life-affirming. Somehow we must all live on after loss and eventually deal with our own mortality in positive ways.
Memento mori is a Latin phrase which translates as "Remember your mortality", "Remember you must die" or "Remember you will die." The phrase has a tradition in art, dating back to antiquity, identifying a genre of artistic work which reminds people of our inevitable earthly fates.
In the relatively modern art form of photography, memento mori often refers to a peculiar Victorian practice, originated in the earliest years of photography, of postmortem portraiture. The invention of the daguerreotype in 1839 made portraiture—once only available to those rich enough to commission a painted portrait—available to people of middle class means. Moreover, with the extremely high childhood mortality rates of the age, a postmortem photograph might be the only image a family could ever have as a keepsake of a lost infant or child.
This practice impresses contemporary sensibilities as macabre. It eventually peaked in popularity around the end of the 19th century and waned as "snapshot" photography became more commonplace with the introduction of the Kodak camera. Yet response to my July 30th post about mummies, "I See… Dead People," has been so unexpectedly strong, I cannot resist the impulse to once again pander to people's morbid curiosities.
However, I do think viewing these images can serve a higher purpose than merely satisfying our gratuitous and arguably voyeuristic urges. They remind us of the pervasive fact of life that without dark and loss, we cannot fully appreciate and optimize the light and love that life has to offer.
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Peppermill Reno is Northern Nevada's premier AAA four diamond resort hotel, offering Reno's best value with award-winning suites, day spa, and luxurious hotel casino accommodations. The Peppermill Resort has 382 luxurious rooms, including 64 suites. Guest room amenities include mini Fridge, sitting areas, luxury linens, safety deposit box access, and in-room movies. Restaurant choices range from Pancho & Willie's fine Mexican to Cafe Milano's 24.
See job opportunities at the Resorts at Wendover. RESERVE ROOM. The Montego Bay Resort is Wendover's newest hotel and casino. PACKAGES. Create your own hotel package! Choose from a variety of concert or golf packages. - Cage Cashier - Gift Shop Office - Purchasing Receiver. MONTEGO BAY - Maids - House Person - Porter - PBX Operator. The Montego Bay Resort is Wendover's newest hotel and casino. PACKAGES. Luxurious, spacious rooms. The Peppermill's spacious 356 square foot Deluxe Queen rooms are made with comfort in mind. Our Deluxe rooms come with contemporary accents, and all the amenities to make your stay comfortable and convenient. 680 Wendover Blvd. Wendover.
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Inspired by the warm golden and earth tones of Tuscany. TThis beautifully appointed 356 square foot Single King Room is inspired by the warm golden and earth tones of Tuscany. Our Single King Rooms have all the amenities to make for a glamorous Peppermill stay. Restaurants near Peppermill Wendover Hotel Casino, West Wendover on TripAdvisor: Find traveler reviews and candid photos of dining near Peppermill Wendover Hotel Casino in West Wendover, Nevada. West Wendover. West Wendover Tourism. 680 Wendover Blvd Montego Bay Hotel & Casino. Peppermill's Dream Team Draft weekly football lineup challenge gives you a shot at over $50,000 in total prizes!Play for a chance to win during all 17 weeks of professional football action. Pick your Dream Team lineup at select kiosks starting at 5pm Tuesday to midnight Saturday, each week. Peppermill Casino Wendover, which also operates under the name Peppermill Inn & Casino, is located in West Wendover, Nevada. This organization primarily operates in the Casino Hotel business / industry within the Hotels, Rooming Houses, Camps, and Other Lodging Places sector.
Reviews from Peppermill Hotel and Casino employees about Peppermill Hotel and Casino culture, salaries, benefits, work-life balance, management, job security, and more. Peppermill Hotel and Casino Employee Reviews. Review this company. Cage Cashier Former Employee - 680 Wendover Blvd, West Wendover, NV 89883 - September 10, 2019. Peppermill Casino Hotel in West Wendover, Nevada has a 36,200 square foot casino with 950 slots, 25 table games, race and sport book and hotel. Address Peppermill Casino 680 Wendover Boulevard West Wendover, Nevada 89883. Contact Information Tel: 775-664-2255 Tel: 800-648-9660 Website Casino. 680 Wendover Blvd Peppermill Hotel Casino West Wendover, NV 89983 775 664-2255. Like most diners you receive the bill at the table and pay the cashier as you leave. Future - With more trips in the future to Salt Lake City, I can see us coming here again. I went here for the prime rib special. Please note the times are in mountain which.
Peppermill Resort Spa Casino is fully committed to promoting responsible gaming and the prevention of underage gaming, and we urge those who gamble to do so responsibly. For the vast majority of people, gambling is an enjoyable form of entertainment. However, we recognize that there are some individuals who are unable to gamble sensibly. Peppermill Hotel Casino's easily accessible wifi is available for a small surcharge. To add a bit more luxury to your stay, check out one of the elegantly spacious suites offered by the hotel.Craving a spa treatment? Check out the extensive list of services at Peppermill Hotel Casino.A great meal is just steps away at the hotel's on-site eatery. Peppermill details section: This casino is located in West Wendover, Nevada. Peppermill has a total of 986 slot machines and 24 table games for your entertainment. WCD also books casino hotel reservations in West Wendover. You will also find pics of Peppermill or find news about Peppermill on this page. There is also a forum all about Peppermill. Presentation of the Wendover Peppermill Casino & Hotel. The Peppermill Hotel Casino is pleased to receive you in its establishment. Located in the Western part of Wendover in Nevada, the resort is well-known for its comfort. The casino has tens of gaming tables and hundreds of slot machines as well as a sports book at your disposal. Find Peppermill Wendover Hotel Casino in West Wendover with Address, Phone number from Yahoo US Local. 680 W Wendover Blvd, West Wendover, NV 89883 Cross Streets:. After staying at a sister property the Peppermill was a bit of a letdown, but still get a 4 rating. The rooms are quite nice although smaller than expected.
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Class Information for Fall 2019: THANKSGIVING IN OCTOBER, Delicious and Healthy Options, 4:00-7:00pm, Tuesday October 29, Palm Ridge Recreation Center, Summit hall A (F178)
Why wait until T-day to enjoy turkey, sweet potatoes, and cranberries? Chef Irma will share some of her favorite fall and winter weather recipes. The menu will include: Smoky Roasted Turkey Breast; Mashed Sweet Potatoes with Lime; Better Brussels Sprouts with Sunchokes & Sage; Mesclun Greens with Roasted Mushrooms, Onions & Balsamic Vinaigrette; Cranberry-Apple Compote with Almond-Agave Drizzle and Caffeine-Free Roasted Coffee Alternative with Coconut or Nut Milk. You'll savor a meal and take-home time-saving tips for holiday entertaining. Wheat-free, gluten-free, dairy-free demonstration. Instructor Irma Mendivil is dedicated to inspiring healthy choices and demonstrating that great taste and good nutrition go hand in hand. Her mission is to awaken your inner chef and inner healer, to enhance your appreciation of the nourishing power of natural foods and your body's innate wisdom and to create public awareness regarding the significant role diet plays on our overall health. Irma teaches classes in private homes, community settings and offers kitchen organization; healthy shopping tours and weekly meal plans with shopping lists. Come and enjoy learning new ways to make simple, delicious and healthy foods and desserts. Irma Mendivil graduated from the Southwest Institute of the Healing Arts, where she earned her degree in Holistic Nutrition. She has a background in education, whole food cooking, and supporting busy people in their healthy lifestyle journey.


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Landing in Dublin, what immediately caught my eye were myriads of healthy little sheep grazing busily in verdant fields of green, welcoming us to the Emerald Isle! My first stop was Dublin, which is a stunning city, the perfect mix of old and new, with lots of interesting things to do and see – a very historical city indeed. I visited the impressive Book of Kells, Trinity College and St. Patrick's Cathedral and enjoyed a distillery tour of Teeling Whiskey Company. I could have spent days here learning its history, and I'm sure our capable guide could have taught me, too! She was brilliant. She walked and talked with me, while teaching me infinite historical facts and literally made Dublin come to life!
One of the stops I made on this amazing trip was the beautiful K Club. While gathered around an elegant, exquisitely set dinner table one evening, after wine tasting in the historic wine cellar with the hotel's sommelier, my group and I were reminiscing about our favorite travel experiences. Each person mentioned faraway places they had visited and why they liked that particular spot the best. When my turn came, I exclaimed that what I loved most about traveling were the people. Throughout my stay in Ireland, I felt as if I had found my very own people! I come from a family that has many unique characteristics, from the way we talk, the way we laugh, to our sense of humor – and I discovered that we are very uniquely Irish! The people of Ireland are warm and inviting, and I hope to return to the many welcoming, friendly faces I was privileged to meet throughout my trip.
Everything about this trip was enjoyable; however, the most special stop was the Dingle Peninsula, one of five jutting peninsulas off the southwest corner of Ireland, extending out from the mainland like giant fingers. National Geographic once called it "the most beautiful place on earth." I was driven all around the Dingle Peninsula, and it was the most exhilarating ride I've ever experienced, whipping through Killarney National Park with wild herds of deer, maneuvering around hairpin turns, and nearly missing sharp, dropping precipices over rugged terrain, around little fjords and through peat bogs. Our guide was fully capable and passionate about this wondrous place of his birth. There I was taking in all of the gorgeous scenery,and then suddenly I was dropped off in what seemed to certainly be the middle of nowhere — somewhere in the Gap of Dunloe.
In the misty rain, I hiked the hills and suddenly met up with a few locals with their jaunting carts pulled by strong, spunky horses. These horses, their owners and their nontraditional carriages carried us nimbly up and trotted down over the hills until we met up with a bridge where we were encouraged to quickly make a wish. Of course, you know what I wished! Then, out of nowhere, I saw a magnificent double rainbow that greeted me along the way in between drops of rain that flew horizontally between the little fjords. At this moment, I felt that I could have packed up my things and moved to this lovely little corner of the world in a heartbeat, but responsibilities and reality beckoned to me. This wonderful trip came to a screeching halt, much to my chagrin.
Leaving the Dingle Peninsula, tears streamed down my face, knowing I had to return home before the crack of dawn the following morning, as I listened to The Old Rugged Cross play on the radio, my grandfather's favorite hymn. He was Scotch-Irish. After experiencing this wonderful glimpse into the little miracle of Ireland, I've learned that it is not just a verdant place of green shamrocks and mischievous leprechauns, Guinness and golfing. Ireland is so much more than the elegant Emerald Isle. I found my people here and know I have been witness to a very spiritual, once-in-a-lifetime experience.NextGEN gallery is not installed/inactive!


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In developing countries, the landscape surrounding agricultural land is important for maintaining biodiversity and providing ecosystem services. Forests provide a full suite of goods and services to subsistence farmers in the Himalayan agro-ecological system. The effects of biomass outtake on woody species richness and composition were analysed in forests under communal and government management. Interviews on forest use and perception of forest condition and ecosystem service delivery were conducted in farmer households bordering the forests.
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Library ResourceJournal Articles & BooksDecember, 2014
Library ResourceJournal Articles & BooksDecember, 2012Colombia, Central America, South America
Payment for ecosystem services (PES) has been widely promoted as an effective and efficient model for conservation; however, few studies have empirically examined how the market-based approach interacts with farmer's decision-making processes and their abilities to sustain new conservation practices. This paper examines the sustainability of a PES silvopastoral programme in Colombia from peasant farmersâ perspectives.
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NEU Launches IAM 2019 In London
Categories: Past Event Articles
Wednesday February 05 2020
The Islamophobia Awareness Month Launch program was a success. With just over 40 attendees and intellectually stimulating panel discussions, the event was a great way to begin raising awareness about Islamophobia.
The panels ranged from Imams,activists and community organisers as well as MEND volunteers. In partnership with the National Education Union, the London Region was able to put together a splendid event that marks the beginning of education and awareness on Islamophobia during this month-long campaign.


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I would not go across the street to talk through a woman.
He began talking to other people through his office computer.
If only she could talk to him through the fire!
He didn't have the power to talk through his mind.
You and I have never talked through any problems together.
We're talking about the effects on kids through age 5.
"I like to talk through the issues before they get done, working things over."
Well if I don't talk them all through five times there's something wrong.
We lived with each other seven days a week, and we'd talk through issues at 2 in the morning.
If you can't talk through every single, possible issue, this is not going to work.


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Next summary: Chapter 1: The Scope of Orientalism
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