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Nobody can underestimate China's place as a global power. It's not shy, coy or diminutive about its ability to lead. It's a veritable leader in statesmanship. And don't let anyone tell you anything else. Because if you do, you may, or may not remain. Where's that doctor from Wuhan who blew the whistle on Coronavirus? Where would WHO's Tedros (no, he's not a real doctor) be without China. The man leads the World Health Organisation and hasn't ever taken the Hippocratic oath. On a sidebar, he's accused of hiding epidemics in Ethiopia. To Soldier #1, a hearty salute. To Tedros we owe the complete lack of accountability on the Chinese regime to shut down Wuhan without letting 7 million people leave the land to infect others around the world. Any doctor worth his name in mud would react with fear when confronted with a highly contagious new virus and alert the health authorities and the government. This doctor told nations to keep their borders open and mouths shut. He castigated nations for drawing "China" by name into all this. Like, virus are all around us and pandemics happen all the time, why blame China. Point taken, Ted. Sowie. Down the army's ranks, I've come across professor Shang Jin Wei, whose column appeared in Business Standard this week: https://www.business-standard.com/article/opinion/beating-covid-19-and-the-economic-pandemic-120032700080_1.html . Soldier #… Titled: Beating Covid-19 and the economic pandemic, it could well be China's notes to itself. Here it masquerades as advice to the world from a former chief economist as the Asian Development Bank. Just like any description of Coronavirus was restricted to likening it to a 'flu' while actually it is more like pneumonia. Same difference? Professor Shang is also a professor of Finance and Economics at Columbia Business School and Columbia University's School of International and Public Affairs. Drumroll. Prof Shang starts with establishing his credentials as to being a master analyst. He says he'd predicted way back in January that the spread of the virus would reach a turning point by mid-Feb. And lo and behold, that's exactly what happened. He then stresses on the fact that since then, however, there are no new cases in China except those spread by international travellers coming into the country. See? China ended it. Successfully. He then offers an empathic "unfortunately" to describe the wide spread of the virus i.e. pandemic. Putting the global political community softly but firmly into the crosshairs for not managing / containing it as well as China did. Please note, he does not acknowledge WHO's (failure) role as a watchdog. He certainly says that the US and the EU did not use their six weeks lead time well. Yeah, maybe they were busy listening to Ted? Now comes the money-maker. He says that if domestic supplies of things like masks, alcohol wipes, etc. are limited, these countries should 'consider' importing from China, Japan and elsewhere. But of course. When the whole world's supply chains are in China, people should go elsewhere. Nice try, prof. He offers consolation: After all, these products are not high-tech and can be manufactured anywhere. "Surely you guys, you big, developed, dodos got this?" But, he panders to our common sense, with: China in particular is eager to resume production, and factories there have the competence, and can respond speedily to a surge in global demand. He also lays out the roadmap for contracting "foreign" – read Chinese – companies to help build emergency hospitals. Being the economist he is, he must do his bit to advise us about the economic aspects of this pandemic. He calls upon policymakers to provide rapid assistance to workers impacted. He warns us of the economic shock travelling downstream and mayhem upstream as demand contracts. He is urging countries to make better use of digital technologies. You see, he lives in the US of A and is talking to all of the developed ones in the world, because that's where numbers are rising exponentially. He's telling them: BE MORE DIGITAL. He says robust online shopping can offset some of the economic difficulties facing retailors and factories. BUT there is a BUT. He says, BUT this requires broad internet availability, widespread acceptance of digital payment by firms and households, and an efficient and inexpensive delivery system. So he adds, "While China is fortunate to have possess all three, many developing countries do not." So friends, he started with, import this and that from China, Japan and others. Then compares others to shit and says well, import from China. Now here's something the Netherlands did: 600,000 masks delivered by China to the Netherlands do not work, offer no protection. Many already in usehttps://t.co/xwoGkrXAST— Bruno Maçães (@MacaesBruno) March 28, 2020 Then, here's something Spain went through: it discovered that the Chinese test kits they'd just imported had only 30% accurate detection rate. Read here: https://www.theguardian.com/world/2020/mar/27/coronavirus-test-kits-withdrawn-spain-poor-accuracy-rate. Most portentous, however, are his words on an economic stimulus: "As for economic stimulus, an internationally coordinated programme will be more effective in tackling a global recession than isolated action by individual countries. This is especially true in the case of fiscal stimulus. When a government cuts taxes or provides temporary financial assistance to needy households, the increase in domestic demand may "leak" to foreign producers via increased imports. This leakage is especially significant for small and medium-size economies that have a relatively high ratio of imports to gross domestic product (GDP), and may discourage them from pursuing enough stimulus." Prof. Shang is China is, for wants an internationally coordinated controlled fiscal stimulus. Reason? To prevent demand from "leaking" to foreign producers via increased imports. I don't understand. How big would the demand from such 'needy' households really be? And if it leaked, wouldn't it benefit China? After all, China is the giant supply chain for the world, isn't it? What is this subterfuge? He wants international coordination to pre-empt this problem. He wants governments to work together (with China at the centre because it holds your supply) to ensure that while we boost demand without changing the exchange rates too much, aided by reducing tariff and non-tariff trade barriers so Chinese companies can move fast and slick. The good professor wants us to particularly go back with the lesson that raising trade barriers is not a good idea even though governments might be tempted to do so in such times. He explains that's because it raises both production costs (for China) and reduces domestic households' real income (hurting their ability to buy more from China) Prof Shang calls for "coordinated trade liberalisation" or in other words, 'let China win because, what choices you got'. He also decorates it with the cherry on top being: "each country's concessions to foreign firms will be met with improved access for their own companies to foreign markets". It;s like this, you buy from China so you can sell in China (efforts to do which, of course, our cheaper products will render unviable). He ends his advice with a rah-rah to the G20 to show some leadership and initiatives: Come on, boys, here's the brief, now make it happen. The last two paragraphs of this are a good look into the psyche of the Chinese machine, so what if it lives, breathes and earns in America. The COVID-19 pandemic threatens the world with disaster. But the crisis also offers governments a rare chance to undertake policy changes that not only address the short-term public-health challenge, but also boost the global economy's long-term growth potential. 600,000 infected (as on date March 29, 2020) is a short term public health challenge and boosting global economy is a "but also" point for this academic death-eater. While the Chinese did not actually invent all the interesting sayings attributed to them, it is true that the Chinese phrase for "crisis" consists of a character signifying "danger" and another for "opportunity." Governments around the world should seize the moment and not waste the COVID-19 crisis. Finally, about the above, you're not telling us anything new, except betraying the Chinese strategy, which will become clearer as the dust settles. Almost as if the Coronavirus is a blueprint for strategy to dominate. Is it any coincidence that parasite was the most acclaimed film this year in Hollow-wood? My last point, I promise. I'm surprised a salesman for China is allowed to call himself an American. The way I see it, America's clutching at the very last threads of propriety and integrity. With the big four of socialism running amok and communists taking over, this is stage IV of world domination. You read it here first. Must go look for a non-Chinese made mask and get used to dealing with failure.
Category: Uncategorized
Why the name change to Disha and other thoughts
Yesterday, I woke up to a new social media trend #DishaCase. The prospect of another rape similar to that of Dr. Priyanka Reddy horrified me all over again. Until I discovered that this was the same case. Same MO. I refer to the MO of police / people changing the name of the victim to protect the dignity of her family. Wait. What? How and at what point did her family lose dignity? Are you, as a society, trying to say that when a man rapes a woman, it is she who loses her dignity? Do you see anything wrong with that logic? The four assholes who raped her, they and their families have lost dignity. The media is yet to drag its spine and brains from medieval era of thinking into the true Indic era of thinking. And time is running out for that. Dear media and their connivers, please, since it's unfair to expect you to evolve at a rate faster than rapists themselves, let me introduce you to this new thought. It might seem difficult to digest at first, but allow this thought to settle: When a man rapes a woman, he AND HIS FAMILY lose dignity. Not the woman AND HER FAMILY. I can't believe that the edict to call her Disha and not her real name came also from Mr. Sajjanar, the same hero being lauded for the encounter. Sir, if you have any respect for the lady and her family, you'll let her memory be. Stop rubbishing the real identities of these brave women AND THEIR FAMILIES, who do so much even in this world to bring up strong, determined women who contribute positively to the society.
12 Rules of Life by Jordan Peterson
Jordan B. Peterson (JBP) is an acclaimed clinical psychologist who has reshaped the modern understanding of personality, says the book starting with the question: 'What are the most valuable things that everyone should know?' JBP has the answer. He has worked out 12 such things, described as profound and practical principles, to help us all lead a meaningful life. Should he be seen as modern-day messiah with a message of his own? Is he inspired by someone who is neither clinical nor a psychologist? The book calls JBP as one of the world's most influential public thinkers, with lectures on topics from the Bible to romantic relationships to mythology… Now the connection is starting to make sense. 12 principles for you and me, whether you're in the USA or in Ethiopia, whether or not you want the same things he wants. The foreword, by Dr. Norman Dodge (DND), thankfully, resonates with the same question that I turned the page with. But, like a boomerang, comes back to me after taking that beautiful flight towards logic. We shall see: The foreword begins with the irony that a clinical psychologist – whom one might see as a servant of science and a friend of humanity – is issuing 12 rules, very much like the 10 commandments, or its like in some other book. So DND starts with calling this out, of course, in good humour. He makes it almost through the point right up to the logical rainbow but alas, doesn't stay there. Instead, he swiftly makes a turn back into the realm of darkness. How? He begins by asking: Isn't life complicated enough, restrictive enough, without abstract rules that don't take our unique, individual situations into account? In my wonderment for this question of his, I only have one response: These lines by D.H.Lawrence (https://hellopoetry.com/poem/73460/self-pity/ ) – It's called Self-Pity and this is what it says: I never saw a wild thing sorry for itself. A small bird will drop frozen dead from a boughwithout ever having felt sorry for itself. I think people who, when they think of life, can only think of how complicated, restrictive it is, will always see misery everywhere around them and then go ahead to make 10 rules and 25 commandments, and 555 laws… and more… It makes them feel safer from all the uncertainties, some of which may include such pleasant moments of joy, fun, and even self-actualisation. Thereby, shutting out some of life's grandest, most joyous potentialities. Such people, aren't they lower than the wild thing in DHL's poem? At least no one will say the small bird didn't live up to its full potential. The opposite can be said about most of us human beings, and thanks to what? Some pithy 12 rules? Commandments? Truths? How does DND explain his view? Through a Biblical story involving Moses. He, who has come down from the mountain with 10 commandments, only to see the Children of Israel in revelry in front of the Golden Calf. How dare they celebrate after having been slaves to the pharoahs! So Moses took to subjecting them to harsh desert wilderness for 40 years, to purify them from their slavishness. It's as if being slaves was a dirty toy they had been lugging around for centuries; and so he sacrificed all compassion, fellow feeling, and inner joy of finally being free, at the altar of purity. What is this obsession with purity, I often wonder. Why is there only one view of purity. Who is he to tell others about what is pure? Now free at last, they were all dancing… so Moses said, I have some good news and some bad news. When DND calls him the lawgiver I take it on authority that he must have had a reference for saying so. I'm looking at the story in all its incredulity, hoping for some major logical breakthrough. This is what I get: Moses the lawgiver (why are so many people giving out laws to others I'll never understand. Besides, who was Moses. Besides, why is JBP doing the same thing today centuries down the line? And now, will JBP also subject us all to harsh desert wilderness?): I've got some good news and bad news. The hedonists replied: The good news. I wish there had been some liberals around to have told him 'stop with the labelling'. "I got Him from 15 commandments to 10." Hmm, negotiating with HIM. He must be pretty desperate. I see that these are the same people who will laugh at stories from my culture where deities talk to common people. Maybe DND wouldn't, his ancestors and his peers certainly did. And continue to do so. Besides, even DND and JBP realise the power of storytelling in driving home the point, a point that's not valid if Hindu cultures do it but the Word of God if 'They' themselves do it. In the interest of moving ahead, I must set aside the rampant hypocrisy. So the gathered public moves on to the bad news and Moses replies: "Adultery is still in". Nothing brightens my day like coming across a cheap crack used by a liberal as a point of debate. And that's the very end of DND's grand questioning – where he says, So Rules There Will Be. The clinical psychologist equivalent of "And it was good". He explains away his lack of rigour with: We are ambivalent about rules, even when we know they are good for us. If we are spirited souls, if we have character, rules seem restrictive, an affront to our sense of agency and our pride in working out our own lives. Why should we be judged according to another's rule? I see him go really close, so close to the truth, which will solve the whole case but he turns his back on it right when he sees a smoking gun. He goes on: And judged we are. As if a mere acceptance of a fact. What about all that education he must have received? He adds further: 'After all, God didn't give Moses "The Ten Suggestions", he gave Commandments; and if I'm a free agent, my first reaction to a commandment might be that nobody, not even God, tells me what to do, even if it's good for me." – Again you see a flicker of light. And then darkness at the end of the tunnel when he says: But the story of the golden calf also reminds us that without rules we quickly become slaves to our passions – and there's nothing freeing about that. "Slave to our passions" is nothing but highly ignorant way of talking. We are slave to our passions because we do not invest in aiming higher as people. Your 10 rules may prevent baser nature, they're not creating enlightenment. So that's that. In my next post, I'll examine the story of the golden calf. But this book is beginning to look a lot like some religious text and maybe that is what it is, a modern-day religious text. In fact, the 2nd last para on page viii says exactly this: Just like Bible has weaved in its laws for mankind through stories, so does JBP. Wow, the analogy is complete. This is hardly clinical in any way! You're basically trying to tell people that we're not good enough, not mature enough to think for ourselves, understand our priorities, and learn from our experiences. You are, as a doctor and as a psychologist, trying to tell people that they need some pithy 12 rules to feel they're leading a meaningful life. A meaning that you've made up yourself. Just like the guys that preceded you. Your basic understanding of your fellow humans is that left to their own devices, they'll be reduced to their baser nature. Is that how much you value this magnificent opportunity called life? For a world-renowned psychologist to think this way is, at best, disappointing.
The Best a Man Can Get is Still Gillette
I wake up to this Gillette ad, which has kicked up a much bigger storm than the Kardashian Pepsi commercial did more than a year ago. I guess that ad was the start of brands taking on the role of SJWs – Social Justice Warriors. SJW is by definition a derogatory term which means a person who expresses or promotes socially progressive views. In a normal world there would be a few thumbs ups for this person but in reality, which is neither normal nor reasonable, the reasons for this are the fact that we have to hold SJWs responsible for having boundary issues. I digressed there. But that is the point. SJWs will stop at nothing. Such as pedophilia being termed as a condition rather than a pathetic scourge of the mankind. They want pedos to be included in the 'queer' category to be represented on the gay pride flag. Because, there is such a thing as a non-practising pedophile. So anyway, this is a small example of why SJWs don't get a lot of respect. What happened then with the Gillette ad was a classic design problem I learnt about during a brief 'knowledge-share' session at my workplace – That when instructions are printed in a font that's harder to read, the reader/user confuses that difficulty with the difficulty level of the task itself. Apparently, Ikea knows this. So thank you Ikea. My male friend had no problem assembling that beige double bed. Moving on to males. They're exploding the dislike button on Gillette's YouTube link. Here it is again in case you'd like to have a go at it too. They're doing so just for suggesting that they are better than the toxic messages they receive from the likes of: Harvey Weinstein Donald Trump Charlie Harper Woody Allen Ramsay Bolton Karl Marx Don Draper Hitler Frank Underwood O J Simpson Aurangzeb John Eric Armstrong (Know more here ) Jack The Ripper List of all the men outed under the Metoo movement. Does not include the stalwarts back in India. Top names though: Alok Nath. Rajkumar Hirani. Vinod Dua. M J Akbar. All renowned ones. Saddam Hussein Jordan Belfort Vladimir Lenin Pol Pot Genghis Khan Geobbels Che Guevara Robert Mugabe (Let me throw in THIS link detailing the respective rules of these powerful men from Africa) Know that some of these characters are fictional but most are not. I trust you to know which is which. But I can tell you this: we haven't even got started. The men who've gotten all riled up with this one ad that is the only sliver of good parenting they have / ever will receive, are the ones for whom this ad was made in the first place. It talks about not waking up to a world where bullying is justified with 'boys will be boys'. And God knows it's the males who are the worst sufferers of it. Instead of saying "yeah, we do have a problem; glad someone is speaking out", they're swearing off of all P&G products. Good going. Yes, a brand's job is to sell. And trust me, sell they will. Gillette has moved on. It's talking to my 25-year-old brother who knows that if his dad shouted at him, that'd be wrong. My 50-plus 'Millennial at heart' friend who hates boys night out where they crack sexist jokes all night long. My friend & ex-colleague whose husband is a hands-on dad who cooks like it's his duty as much as hers. Did you know that brands were acting as SJWs when they asked you to wash your hands 4 times a day, for 30 seconds each time? That you needed to wear a deo. That you need to floss your teeth. Brush it twice a day. They you need to get your vitamins. That you need to safeguard your heart health with MUFA-PUFA loaded oils. That you need life insurance for your families. Well, dear men, you need to give up bullying for a healthy society.
Aiyoh – Made in China da!
So, since I have glossophilia, this news is something I always look forward to: OED i.e. the Oxford English Dictionary has come out with its list of new words added this year. And every year round, a couple of Indian expressions find their rightful place and it helps us continue to look on to the Englishman with regard. This time, Aiyoh has made it to the hallowed rolls. With another discovery looming. Backstory: I'm a Gujju who finds it utterly normal to utter Aiyoh when expressing shock, awe, or surprise. And that's not normal at all. So when my fave Aiyoh made it to OED, imagine my sense of vindication (Aiyoh in OED) ! Then imagine my sense of disappointment upon finding out that all this time I had been speaking Chinese. Kudos to my multilingual self but still! Turns out, Aiyoh is of Mandarin origin and Aiyah, Cantonese. So, quite literally the most used word in the South, almost like a punctuation mark, isn't Indian at all. BTW – glossophile is one who loves languages. Which brings me to another observation: Almost all of our languages have some entirely versatile words that can mean an entire range of emotions, and interpretation of which depends on who employs it, how, and when. Like Achcha in Hindi. Achcha literally means 'good'. As in, How are things? – Achcha hai! As in… Achaha, so you think you're so smart! I'll show you! | Achcha? Is that what happened? | Achcha, I thought so. | Achcha, okay, I'll do it. So, basically, it's a reflection of a very pluralistic culture here. These are the Indian words that made it: Langra (the Mango variety), Tithi (dates in the lunar calendar) Very much like the head wobble we Indians do, which also could mean anything from okay to good, to yes, to I don't know, my bad… and whatever else you want. Are there any such words in your language that mean a whole spectrum of things?


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HR Consultancy Service in Spain
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HR Consultancy Service
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Due to the very nature of their position, employers tend to need advice on employee relations now and again. Accordingly, the ability to have an English-speaking expert in the area, able to provide advice at a predefined cost is vital to the smooth running of your business and can reduce concerns about potential liabilities, as well as advise on how to avoid incurring such liabilities.
What does this service consist of?
- An initial discussion with an experienced English-speaking employment lawyer to understand the nature of your business and employee relationships
- Where required provision of initial advice on employment contracts, working environment and other important issues such as legal entitlements that employees hold
- Advice on an ad hoc basis at pre-defined rates per hour, in minimum increments of 12 minutes.
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subset: commoncrawl


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Like Herbert, many scientists and engineers also report heightened states of creativity while using LSD. During a press conference on Friday, Hofmann revealed that he was told by Nobel-prize-winning chemist Kary Mullis that LSD had helped him develop the polymerase chain reaction that helps amplify specific DNA sequences.
Computer science, United States Army, World War II, Jimmy Carter, United States Air Force
Evolution, Embryology, Physics, Charles Darwin, Molecular biology
DNA replication, Nobel Prize in Chemistry, Genetic engineering, Quantitative PCR, DNA melting


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The first New Belgrade condominium coming soon: WELLPORT
The official ceremony marking the beginning of construction of the very first condominium in New Belgrade, bearing the name Wellport, was held in the premises of the Yugoslav Film Archive. The ceremony was attended by the Ambassador of the State of Israel to the Republic of Serbia H.E. Madam Alona Fisher-Kamm.
This project, which aims to fulfill all the needs of modern families today by providing a number of family-friendly amenities, is developed by the esteemed Israeli company Shikun & Binui Group, known to the local public for its condominiums Central Garden and Duke's Gates. More than 400 guests from the world of business, culture and the media had the opportunity to get acquainted with this project worth 130 million Euros.
Wellport residential complex, designed by the world famous Israeli architect Rami Wimmer, will consist of 500 state-of-the-art residential units, ranging from studios to 4-bedroom apartments. The complex will be constructed in four phases. It is designed in a way to provide future residents with premium quality that relies on natural materials, as well as carefully selected finishes and furnishings that go hand in hand with the most modern technologies and energy efficiency principles.
Private parking, a sport courts, professional maintenance, closed park, reception and security personel, as well as key card access, are just some of the amenities that the very first New Belgrade condominium will offer to its future residents.
Mr. Gili Dekel, a partner-investor of the project, stated: "It is our great pleasure to present the new residential complex Wellport, another successful project by the Israeli company Shikun & Binui Group. In New Belgrade, which is an increasingly more popular residential neighborhood, we will build homes for 500 families, whilst adhering
to the high quality standards that encompass luxury interiors, comfort and safety for all future residents. I am thankful to the officials from the City of Belgrade and the Government of the Republic of Serbia for the fruitful cooperation, thus far, which, I am sure, will continue into the future".
As a symbolic gesture, Mr. Gili Dekel presented a ship's rudder to Mr. Guy Dvorin, the Chief Executive Officer of Shikun & Binui Group's European subsidiary, and ask him to "successfully guide the project to its final safe harbor."
The Ambassador of Israel to the Republic of Serbia H.E. Ms. Alona Fisher-Kamm said at the occasion: "Shikun & Binui is one of the leading Israeli infrastructure and real estate companies – it is a global corporation active in more than 20 countries across 4 continents. I am very proud to witness the presentation of the
company's third project in Serbia – Wellport residential complex. I am certain that this endeavor will be as successful as its predecessors and that it will provide its residents with a unique urban oasis in the municipality of New Belgrade, which is continuously growing and developing."
CBS International, the leading real estate consultancy in Serbia and a member of the Cushman & Wakefield Group, has been entrusted to be the exclusive sales representative for Wellport apartments.


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Have you recently installed Windows 10 19H2 on your device which doesn't support the new changes? If yes, try to fix the installation issue of the October 2019 update. In case, you still fail to diagnose the problem, it would be better to roll back to the prior Windows updates. Today, in this blog, we elaborate different workarounds to uninstall the Windows 10 version 1909 Update without damaging any system files.
Windows 10 version 1909 comes with lots of new changes and enhancements with its compatible devices. Unlike Windows 10 May 2019 Update, this version too has some minimum system requirements. If your system doesn't meet these criteria, it starts generating compatibility issues. If that's the case, you have no other option than reverting back to the earlier installation.
Warning: Before switching back to the previous update, make sure to create a full backup of Window's files. This may help to repair the damaged files if anything goes wrong during a System Restore.
How to uninstall Windows 10 version 1909 Update
Here, we explain different ways to uninstall Windows 10 October 2019 update on your PC.
1} Uninstall Windows 10 19H2 for May 2019 (1903) Users
If you are currently having Windows 10 19H1 update, you need to follow the below outline to use the recovery option-
Step-1: Press Win and I hotkey together to invoke the Settings app.
Step-2: From the different categories, click Update & Security then Windows Update on the succeeding screen.
Step-3: Subsequently, switch to the right-hand side and hit View update history link.
Step-4: When the new window appears, tap the first option Uninstall updates to proceed ahead.
Step-5: Now, choose the Update for Microsoft Windows thereafter Uninstall option from the top ribbon on the same page.
Step-6: Henceforth, you will receive a confirmation message; press Yes to move ahead.
Step-7: Once finished, hit Restart now button to refresh your computer.
After following all the steps successfully, your computer will revert back to the previous version of Windows 10 update i.e 1903.
2} Uninstall Windows 10 1909 for October 2018 (1809) users
In case, you jump directly to Windows 10 19H2 from 1809 or older updates, follow these guidelines to switch back to the previous version.
- Right-click on the Start icon and choose Settings from the appeared power menu.
- When the different categories come up, select Update & Security followed by the Recovery option on the left column.
- Thereupon, press Get started button under Go back to the previous version of the Windows 10 section on the adjacent right pane.
- Here, select any of the reasons that you feel to uninstall the 1909 Update thereafter hit Next button.
- Succeeding after click "No, thanks" option followed by the Next on the warning page.
- At last, select the Next option again then Go back to an earlier build button.
Once all the steps are completed successfully, your system will delete the recent firmware and its components. In this way, your computer will revert back to the previous version.
Restore to the previous version of Windows 10 option is not located
The automatically created Windows.old folder after upgrading the Windows 10, also gives option to rollback the system to the previous installation. This is a unique feature that allows users to revert their PCs in case, the latest version generates bugs. Here's how to proceed-
- Jointly Press Win and E hotkey to launch the File Explorer.
- Thereupon, select This PC option thereafter explores C: drive (which contains OS).
- Here, double click on Windows.old henceforth User directory.
- Going ahead, open the user-name folder and select the file that you want to retrieve.
- Now, right-click on it and select copy then paste this file inside Windows 10 folder.
- Lastly, Restart your computer to save the changes made so far.
Note: The Windows.old is only available till the 10 days of installation completes. If you can't see this folder in C: drive, you won't be able to roll back to the previous version. Moreover, this directory occupies huge space of your HDD. As a result, your system becomes slow in operation. After ten days of original installation, the system by default removes Windows.old folder from the hard drive.


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No Fee Biggest Senior Online Dating Sites
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I have never voted. Like most people I am utterly disenchanted by politics. Like most people I regard politicians as frauds and liars and the current political system as nothing more than a bureaucratic means for furthering the augmentation and advantages of economic elites. Billy Connolly said: "Don't vote, it encourages them," and, "The desire to be a politician should bar you for life from ever being one.
From a barn-burner of an essay from Russell Brand about politics. We no longer have the luxury of tradition
His observations about left-ist political movements lacking excitement are pretty interesting:
As John Cleese said, there is a tendency to confuse seriousness with solemnity. Serious causes can and must be approached with good humour, otherwise they're boring and can't compete with the Premier League and Grand Theft Auto. Social movements needn't lack razzmatazz.
The right has all the advantages, just as the devil has all the best tunes. Conservatism appeals to our selfishness and fear, our desire and self-interest; they neatly nurture and then harvest the inherent and incubating individualism.


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I hope MS will introduce something along the lines of "Cortana Background Agents". It would allow developers to introduce commands without having to start an application. A good example would be a dictionary definition app or a WolframAlpha app.
You could say "define 'cool'" which would trigger a dictionary defining background agent.
Code wise, it might look like this:
The code above will grab the definition for the specified word and show it from inside of Cortana, without starting a dictionary app or performing a Bing search. There are other uses for this such as a calculator or a custom Google search.Code:
using System;
public class DictionaryDefinitionAgent: CortanaBackgroundAgent
public override Task InvokeAsync(CortanaWrapper cortana, SpeechAgentInvokedEventArgs args)
//Entry point for the background agent.
var deferral = await args.GetDeferral(); .//We know this task may take longer than 3 seconds so let the system know this. Cortana could say "hold on a second".
var wordToDefine = args.Arguments[0]; //Get "cool"
//insert magic code to get definition here
cortana.Say("The definition of {0} is \"{1}\", wordToDefine, definition); //tell Cortana to say the definition
Perhaps we can set triggers that would allow these agents to run at start-up (and limit it to one, specified by the user). It could be used to say or name or something.
I don't know, I just can't wait for the API to be released (if it hasn't already). What do you guys (and gals) think?


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China – "MDLSX" by Motus theatre company
After more than two hundred performances, the half of which abroad in important theatre and international festivals around the world, MDLSX -the show "hymn to freedom, to being and becoming other than the body"- keeps on being successfully staged.
Now it is presented by Motus and Silvia Calderoni at the Hong Kong International Black Box Festival, where the show is on stage from the 17th to the 21st of October.
Here is the presentation curated by the Festival of a show defined "explosive".
«When identity and gender definitions are stripped away, who do you see? In a partly autobiographical 80-minute monologue, Premio Ubu-winner Silvia Calderoni peels away layers of scientific and historical convention and challenges the audience to re-imagine individual identity beyond the definitions of binary gender.
Combining her own androgynous physicality with texts based on personal, researched and fictional experience, projected home movies, interviews and a powerful soundtrack, DJ-ed "live", Calderoni presents a visceral and delicately balanced depiction of the violence, bewilderment and emotional unravelling of an individual trapped in an imposed identity, and a journey towards authenticity and self-acceptance.
A wild, charismatic performance that will take your breath away».
A talk with the artists is moreover programmed on October 17th, after the show.
Hong Kong International Black Box Festival


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Anthony Yamson joined Stifel's European Technology Team in London in 2013 and currently is Vice President in the Stifel Global Technology Group supporting the Internet & Digital Media investment banking efforts in New York. He has diverse transaction experience across investment banking products including M&A, IPOs, Follow-ons, Private Placements, and LBOs. Within the Internet sector he spends time across various sub-sectors including listing and marketplace businesses, online video, social media, SMB services, marketing technology, and eCommerce business models.
Prior to joining Stifel, Anthony worked at Deutsche Bank, where he had been covering Technology, Media and Telecom across Europe since 2011. Prior to joining Deutsche Bank, he was a corporate lawyer at Lehman Brothers in London.
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When a group of international media organisations this week revealed details of a Chinese tech company's vast database profiling millions of people around the globe, it was in no small part due to a small Australian cybersecurity firm established only last year.
The Canberra-based firm, Internet 2.0, was co-founded by the cybersecurity expert Robert Potter, who was an adviser to the then Labor MP Gai Brodtmann when she was the shadow assistant minister for cybersecurity in Bill Shorten's opposition. He later took a role with the Department of Foreign Affairs and Trade as a contractor.
The company's other co-founder, David Robinson, is a retired captain from the Australian Army Intelligence Corps who also describes himself as a "serial entrepreneur". Their customers include the US and Australian governments.
Potter said his firm was respected for its work on North Korea and China and a mutual friend introduced him to the US academic Christopher Balding, who was previously based in the Chinese city of Shenzhen.
Balding has said he received the leaked materials from an individual who had put themselves at risk by providing the data – proof, he said, that many inside China were concerned about surveillance practices in the country.
Potter said the leaked files contained large amounts of data but were corrupted, so Balding had sought his help to recover as much information as possible. The pair started speaking in April, forming a partnership that laid the groundwork for the publication of the details in a range of media outlets including the Australian Financial Review, the Daily Telegraph in the UK, and the Washington Post in the US. Potter also offered storage space for the data that was being examined.
Potter, a former head of cyber operations at the private security firm BAE Systems Applied Intelligence, said his company had been able to recover the records of about 250,000 people from the leaked dataset, including about 52,000 Americans, 35,500 Australians and nearly 10,000 Britons. They include politicians, including the prime ministers Scott Morrison and Boris Johnson and their relatives, the royal family, celebrities and military figures.
On Tuesday, the Australian Labor Party asked the information commissioner to investigate the "deeply concerning" reports and whether any Australian privacy laws may have been breached.
The Labor senator, Jenny McAllister, who chairs a Senate select committee into foreign interference through social media, said the reports about the database were "the latest in a long line of warnings that there are actors with the intent and ability to influence Australia's democracy".
Zhenhua Data, based in Shenzhen, has denied any links to the Chinese government or military and insisted that it merely "integrated" public data found on the internet.
A representative of Zhenhua Data told the Guardian that a database, known as the Overseas Key Information Database, did exist but that it was "not as magical" as suggested in foreign media reports because it simply connected individuals to the social media they used.
With some Australian-based analysts also questioning the significance of the leaked materials, Potter conceded that most of the data was based on material openly available on platforms such as Twitter, Facebook, Crunchbase and LinkedIn.
But collecting vast troves of data in this way raised important questions, he said. "Open source doesn't necessarily mean people want it to be public," Potter told Guardian Australia at Parliament House in Canberra.
"The reason Cambridge Analytica was scandalous wasn't because they were accessing information on people's private messages on Facebook. It was because they were misusing the permissions that were given by users to those platforms."
Potter said the database showed attempts had been made to uncover the criminal records of anyone in Queensland with the last name Gilmour. Because these searches were tagged "space", he formed a view that the effort reflected an interest in finding details related to a space technology company in Queensland, Gilmour Space Technologies. Ultimately, however, there were no criminal records of people at that company, he said.
"If you combine that with publicly available information and you start scraping for criminal activity around somebody's name, you're into the security vetting and intelligence vetting side … you're not just looking at someone's Twitter at that point. You're gathering multiple sources together to make an assessment of vulnerability."
A Gilmour Space Technologies spokesperson said the company was aware of the story and security was "an ongoing concern for all companies developing innovative research and technology, and we are continuously evolving our processes and systems to mitigate these risks".
Potter said the database also showed "a huge amount of effort to to categorise data around universities, particularly crime data, to see if that criminal data matches the names of staff". He cited the case of a janitor at an Australian university – which he did not name – who was working in a sensitive lab and apparently had a criminal record.
"So that's the sort of insight that people look to get from shaking out the open source intelligence data at large scale."
Asked whether Australian and other western intelligence services would similarly be scraping public open source material, he rejected the comparison by pointing to the safeguards that would apply in that case.
Potter said he would not discuss his career history in great detail, but he had previously worked "in a space where we developed and employed this sort of technology on behalf of like-minded democratic countries for the purposes of national security".
"And we operate very differently," he said.
"Mosaic collection of intelligence is particularly dangerous and generally operates only within intelligence agencies at this scale. We follow pretty significant rules and have non-trivial amounts of oversight.
"And I think it'd be fair to say to somebody from the Guardian that we've gotten ourselves in more than enough trouble over the years with that. So imagine that with no inspector general of intelligence and security [and] no free press staring down their heels."
Amid diplomatic tensions with China, the Australian government responded to the reports in a relatively subdued way, with several ministers saying the information would be concerning if true.
Speaking to the ABC, the education minister, Dan Tehan, indicated Australia's intelligence agencies would "investigate to see whether these claims, and this reporting, is accurate" and action would be taken if necessary.


text:
Latest news from the world of science and technology.
The UK's largest innovation centre, Plexal, based at Here East on the Queen Elizabeth Olympic Park, was designed and built in a record-breaking 12 months and opened by Mayor of London, Sadiq Khan and CEO, Claire Cockerton, in June 2017.
German startup Zenkit is bringing the platform closer to its users by introducing its services in eight new languages, with plans to release five more in the coming months.
bridgX, a Belgian provider of implementation and strategic services for SAP HCM and SAP® SuccessFactors®, announced today that it has achieved the SAP Silver Partner level.
PSI Services LLC (PSI), a worldwide testing provider, today announced that they have acquired Innovative HR Solutions (IHS), experts in individual, team, and organisational assessment and development, with a focus on using leading products and deep regional experience to achieve enduring business outcomes.
wasl Asset Management Group, one of the largest real estate development and management companies in Dubai, has broken a Guinness World Records title for the largest aerial projection screen, which took to the skies in celebration of the 'Year of Zayed 2018'. The record-breaking effort is part of wasl's wider efforts to unite the country in commemorating the late Sheikh Zayed bin Sultan Al Nahyan, the Founding Father of the UAE.
Katalyst is pleased to announce its partnership with KnowBe4 Security Awareness. KnowBe4 is the world's most popular integrated platform for awareness training combined with simulated phishing attacks.
VENNCOMM has punctuated its 2017 market success by completing a £1.6 million equity funding led by HNW investors; Ex ITN CEO, Mark Wood and Ex BT Global Services CEO, Luis Alvarez Satorre. Mark will be the company's Non-executive Chairman with Luis leading the Advisory Board.
Link Asset Services (LAS) a annoncé deux nominations au niveau du Conseil d'Administration dans le but d'encourager sa croissance sur le marché luxembourgeois, en renforçant son expertise liée à l'industrie des fonds d'investissement et aux services corporates dans la région.
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DJ Khaled Confirms His Upcoming Album Will Feature Travis Scott And Post Malone
Since 2016, DJ Khaled has reestablished himself as a significant participant in hip-hop music. The seasoned producer got here again in full pressure together with his albums Major Key and Grateful, which featured the likes of Chance The Rapper, Justin Bieber, Rihanna, Migos, and Future. Ahead of his upcoming Father Of Asahd album, DJ Khaled has teased new collaborations with each Travis Scott and Post Malone.
Stemming from a protracted historical past of collaboration, Travis Scott has already linked with DJ Khaled quite a few occasions to seem on Major Key's "Tourist" and 4 tracks on Grateful. Claiming that he'll be bringing Astroworld to Father Of Asahd, Travis Scott and DJ Khaled's upcoming collaboration is promised to be one in all their greatest hits but.
Post Malone, alternatively, has but to work with the long-lasting hip-hop producer. Having labored with producers like Metro Boomin, DJ Mustard, and London on da Track, it was solely a matter of time earlier than Post linked up with DJ Khaled. In an Instagram video posted yesterday, DJ Khaled said, "They said I couldn't get Post Malone on the album, so I went and got Post Malone."
With these large collaborations already confirmed, DJ Khaled's upcoming album is certain to be nothing in need of stellar. Be looking out for Father Of Asahd later this yr.
Bringing #ASTROWORLD🚀🌵to #FATHEROFASAHD 🔑 FANLUV! I PROMISE YOU! THIS MY BIGGEST ALBUM YET! TRUST ME! JUST KNOW we coming BIG! @wethebestmusic !
📸@jamiefcw pic.twitter.com/EVpeHpHorE
— DJ KHALED (@djkhaled) February eight, 2019
They stated I can't get put up on my album so I obtained @postmalone !
FATHER OF ASAHD THE ALBUM 2019 ! @wethebestmusic ! 🎥🎞🔑 styled by @terrellish pic.twitter.com/4ek29YgoLj
— DJ KHALED (@djkhaled) February eight, 2019
▲ ▲ Read More About DJ Khaled Here ▲ ▲
Read extra from Jordan and join together with her on Soundcloud, Twitter, and Instagram.
DJ Khaled Confirms His Upcoming Album Will Feature Travis Scott And Post Malone


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United States District Court, D. Colorado
March 6, 2018
TERRI COLEMAN, Plaintiff,v.NANCY A. BERRYHILL, Acting Commissioner of Social Security, Defendant.
A. BRIMMER United States District Judge.
matter comes before the Court on the Complaint [Docket No. 1]
filed by plaintiff Terri Coleman on April 23, 2016. Plaintiff
seeks review of the final decision of defendant Nancy A.
Berryhill (the "Commissioner") denying her claim
for disability insurance benefits and supplemental security
income under Titles II and XVI of the Social Security Act
(the "Act"), 42 U.S.C. §§ 401-33. The
Court has jurisdiction to review the Commissioner's final
decision under 42 U.S.C. § 405(g).[1]
On May
3, 2013, plaintiff applied for disability insurance benefits
and supplemental security income under Titles II and XVI of
the Act. R. at 10. Plaintiff alleged that she had been
disabled since April 4, 2013. Id. After an initial
administrative denial of her claim, plaintiff received a
hearing before an Administrative Law Judge
("ALJ") on October 30, 2014. Id. On
November 21, 2014, the ALJ issued a decision denying
plaintiff's claim. Id. at 10-24. The ALJ found
that plaintiff had the following severe impairments: mild
neurological disorder, adjustment disorder with depressed
mood, and mild degenerative disc disease within the lumbar
spine with additional references to sciatica. Id. at
12-13. The ALJ concluded that these impairments, alone or in
combination, did not meet one of the regulations' listed
impairments, id. at 14, and found that plaintiff had
the residual functional capacity ("RFC") to
perform light work as defined in 20 CFR 404.1567(b) and
416.967(b). The claimant is able to lift, carry, push and/or
pull 20 pounds occasionally and 10 pounds frequently. The
claimant is able to stand and/or walk about six hours out of
an eight-hour workday. The claimant has no limitations
regarding sitting. The claimant is able to frequently climb
ramps and stairs as well as balance. The claimant does not
require the use of an assistive device for ambulation. The
claimant should not work around hazardous heights or climb
ladders, ropes or scaffolds. The claimant cannot be required
to operate machinery involving dangerous mechanical parts.
The claimant is able to understand, remember and carry out
tasks learned in up to six months.
Id. at 16. Based upon this RFC, the ALJ concluded
that plaintiff was incapable of performing her past relevant
work as a substance abuse counselor. Id. at 21.
However, the ALJ, in reliance on the testimony of a
vocational expert ("VE"), concluded that
plaintiff had the RFC to perform the requirements of office
helper, ticket taker, and mail clerk. Id. at 22.
March 2, 2016, the Appeals Council denied plaintiff's
request for review of the ALJ's denial of her claim.
Id. at 1. Given the Appeals Council's denial,
the ALJ's decision is the final decision of the
Standard of Review
of the Commissioner's finding that a claimant is not
disabled is limited to determining whether the Commissioner
applied the correct legal standards and whether the decision
is supported by substantial evidence in the record as a
whole. See Angel v. Barnhart, 329 F.3d 1208, 1209
(10th Cir. 2003). The district court may not reverse an ALJ
simply because the court may have reached a different result
based on the record; the question instead is whether there is
substantial evidence showing that the ALJ was justified in
her decision. See Ellison v. Sullivan, 929 F.2d 534,
536 (10th Cir. 1990). "Substantial evidence is more
than a mere scintilla and is such relevant evidence as a
reasonable mind might accept as adequate to support a
conclusion." Flaherty v. Astrue, 515 F.3d
1067, 1070 (10th Cir. 2007). Moreover, "[e]vidence is
not substantial if it is overwhelmed by other evidence in the
record or constitutes mere conclusion." Musgrave v.
Sullivan, 966 F.2d 1371, 1374 (10th Cir. 1992). The
district court will not "reweigh the evidence or retry
the case, " but must "meticulously examine the
record as a whole, including anything that may undercut or
detract from the ALJ's findings in order to determine if
the substantiality test has been met."
Flaherty, 515 F.3d at 1070. Nevertheless,
"if the ALJ failed to apply the correct legal test,
there is a ground for reversal apart from a lack of
substantial evidence." Thompson v. Sullivan,
987 F.2d 1482, 1487 (10th Cir. 1993).
The Five-Step Evaluation Process
qualify for disability benefits, a claimant must have a
medically determinable physical or mental impairment expected
to result in death or last for a continuous period of twelve
months that prevents the claimant from performing any
substantial gainful work that exists in the national economy.
42 U.S.C. § 423(d)(1)-(2). Furthermore,
[a]n individual shall be determined to be under a disability
only if his physical or mental impairment or impairments are
of such severity that he is not only unable to do his
previous work but cannot, considering his age, education, and
work experience, engage in any other kind of substantial
gainful work which exists in the national economy, regardless
of whether such work exists in the immediate area in which he
lives, or whether a specific job vacancy exists for him, or
whether he would be hired if he applied for work.
42 U.S.C. § 423(d)(2)(A) (2006). The Commissioner has
established a five-step sequential evaluation process to
determine whether a claimant is disabled. 20 C.F.R. §
404.1520; Williams v. Bowen, 844 F.2d 748, 750 ...
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text: Iacobelli Retired Before UAW Talksby Bill Cawthon on June 9, 2015 at 5:15 pm EDT Alphons "Al" Iacobelli, Fiat Chrysler's head of employee relations, has retired with United States union contract talks coming in July. Detroit native Mr. Iacobelli joined Chrysler Corporation in 1993, and was appointed vice president for employee relations for Chrysler Group in July 2008. He has been in charge of labor relations and has led the company team in negotiations with the United Auto Workers, which represents most FCA hourly employees in the United States and Mexico. Canadian workers are in a different union. Glenn Shagena, the head of FCA Mexico Human Resources, is replacing Mr. Iacobelli. He was the human resources director for manufacturing, and headed up labor relations, including the World Class Manufacturing rollout in North America. Mr. Shagena joined Chrysler Corporation in 1985, working in the Labor Relations department at the Sterling Heights Assembly Plant in Michigan. He is a graduate of the University of Pennsylvania with a Bachelor's degree in Economics and a Master's degree in Organizational/HR Development from Case Western Reserve University. Share me!RedditFacebookTwitterMorePrintTumblrLinkedInGoogle


text:
A licence to kill during inflammation
Inflammation can help to eliminate infection, but excessive inflammation can cause damage to the body. The sensor proteins that trigger an inflammatory immune response must therefore be carefully regulated. Some intracellular immune-sensor proteins detect components in a cell that become abnormal or altered during a cellular crisis. Signs of cellular crisis are sometimes produced in the absence of an infection, so mechanisms are needed to prevent the proteins from triggering an inappropriate inflammatory response. Writing in Nature, Sharif et al.1 report a structural study that investigates an immune-sensor protein called NLRP3, revealing that a protein called NEK7 acts as a 'licence' that enables this protein to cause inflammation.
When an immune sensor recognizes a hallmark of infection in the cytoplasm, this can activate the protein and lead to the assembly of a multiprotein complex called an inflammasome. The activation of proteins that function downstream of an inflammasome can potently drive both inflammation and cell death2. Different types of inflammasome can form depending on the sensor components involved. Certain inflammasomes respond to a highly specific trigger: for example, those in mammalian cells containing the sensor protein NLRC4 respond to the presence of the bacterial protein flagellin3,4.
Proteins that are normally present in mammalian cells do not seem able to trigger the accidental formation of NLRC4-containing inflammasomes, given the lack of reports of such aberrant events. By contrast, inflammasomes that contain NLRP3 are activated when NLRP3 recognizes — by an as yet unknown mechanism — hallmarks of cellular catastrophe, such as extremely low concentrations of potassium in the cytoplasm, or signs of dysfunction in organelles called mitochondria2. Such events can arise from tissue damage that is unrelated to infection, and NLRP3 activation in such cases has been implicated as a possible cause of inflammatory diseases such as atherosclerosis.
It is widely accepted that the tightly regulated formation of NLRP3-containing inflammasomes occurs in two steps. In the first step, NLRP3 is primed for action by other immune-sensor proteins called TLRs, which can detect components of microorganisms. This priming step occurs in two ways2: NLRP3 can undergo a modification, such as the addition of a phosphate group or the removal of an attached ubiquitin protein. Further priming is achieved by a rise in expression of the gene that encodes NLRP3, increasing the chance that NLRP3 will detect any abnormalities. The second step, activation, then results in NLRP3 proteins binding together to form part of a disc-shaped inflammasome complex that is probably similar to those of other inflammasomes containing proteins of the NLR family (which includes NLRP3 and NLRC4)5,6. This activation step occurs during a cellular catastrophe, but the biochemical and structural mechanisms involved are unknown.
Researchers have long sought to determine the structure of NLRP3 as it forms an inflammasome, in the hope of gaining insights into how this protein functions. However, such efforts have been unsuccessful, perhaps because unknown protein partners that interact with NLRP3 were missing from earlier attempts.
The discovery7–9 that the enzyme NEK7 is essential for NLRP3 signalling provided a missing part of the puzzle. NEK7 regulates processes that occur during cell division, such as the breakdown of the nuclear-envelope structure10, so it was surprising to find that it has a separate role in inflammation. This suggested that NLRP3-containing inflammasome formation doesn't occur during cell division because NEK7 is unavailable to aid inflammasome assembly8. NEK7 regulates NLRP3 signalling by binding to a region of the protein known as the LRR domain8,9. However, why such an interaction between NEK7 and NLRP3 is essential for inflammasome formation has remained elusive.
To tackle this question, Sharif et al. used cryo-electron microscopy to investigate the structure of a human NLRP3 interacting with NEK7. The authors' structural data reveal that NLRP3 and NEK7 bind to form a dimer in which NLRP3 is in an inactive conformation. In this state, the LRR domain of NLRP3 has a lobed, semicircular shape (Fig. 1), and the carboxy-terminal region of NEK7 nestles in the inner curve of the LRR.
NLRP3 also contains a structure called the NACHT domain, and in the inactive NLRP3–NEK7 complex, this domain is structurally very similar to the NACHT domain11 of inactive NLRC4. It was previously shown5,6,11 that the NACHT domain of NLRC4 rotates as it transitions into an active conformation. This rotational-activation step uncovers part of the NACHT surface, enabling inflammasome formation through a protein-assembly process called oligomerization, and generating a disc-shaped NLRC4-containing inflammasome5,6. The authors used this information to model a hypothetical conformation for an NLRP3-containing inflammasome.
In Sharif and colleagues' model, the hypothetical rotational activation of NLRP3 doesn't affect NEK7 binding, and NEK7 still fits into NLRP3's LRR domain in the same way as in the inactive structure. Furthermore, the authors made the surprising discovery that NEK7 provides a bridge between adjacent NLRP3 proteins, by forming an interface with the LRR of the adjacent NLRP3 in the inflammasome. The ability to form such an interface suggests that NEK7 provides a licence for NLRP3 to form part of the inflammasome. It seems that this licensing event occurs independently of both the priming and rotational-activation steps, because the authors did not include molecules that cause priming or add triggers for rotational activation in their structural studies. The results suggest a revised view of how the NLRP3-containing inflammasome is regulated, and put forward the idea that NLRP3 oligomerization requires NEK7 licensing. Taken together with evidence from earlier studies7–9, it seems likely that this licence is revoked during cell division.
The function of NEK7 in the NLRP3-containing inflammasome is interesting when considered in relation to the structure of the NLRC4-containing inflammasome. The LRR domain of NLRC4 is longer than that of NLRP3, and makes direct contact with the LRR of the adjacent NLRC4 protein in the inflammasome5,6. In an NLRP3-containing inflammasome, NEK7 fulfils a similar connecting role by making contact with adjacent LRR domains. This explains why NLRP3-containing inflammasomes require NEK7 licensing, whereas NLRC4-containing ones do not.
Many mysteries concerning the regulation of NLRP3-containing inflammasomes remain. Perhaps future structural studies will reveal how NLRP3 modification accomplishes the priming step.
Finally, we still don't know the answer to perhaps the most important question of all: what direct interaction between NLRP3 and an unknown cellular factor results in the formation of the inflammasome? Perhaps the evidence that the NEK7 licence is revoked during cell division provides a clue. If inappropriate activation of NLRP3 is likely to occur during cell division, then having an NEK7-licensing step would help to combat this potential problem. Thus, one could imagine that the type of cellular catastrophe detected by NLRP3 also occurs during cell division but in a controlled manner.
Nature 570, 316-317 (2019)
- 1.
Sharif, H. et al. Nature 570, 338–343 (2019).
- 2.
Swanson, K. V., Deng, M. & Ting, J. P.-Y. Nature Rev. Immunol. https://doi.org/10.1038/s41577-019-0165-0 (2019).
- 3.
Miao, E. A. et al. Nature Immunol. 7, 569–575 (2006).
- 4.
Franchi, L. et al. Nature Immunol. 7, 576–582 (2006).
- 5.
Zhang, L. et al. Science 350, 404–409 (2015).
- 6.
Hu, Z. et al. Science 350, 399–404 (2015).
- 7.
Schmid-Burgk, J. L. et al. J. Biol. Chem. 291, 103–109 (2016).
- 8.
Shi, H. et al. Nature Immunol. 17, 250–258 (2016).
- 9.
He, Y., Zeng, M. Y., Yang, D., Motro, B. & Núñez, G. Nature 530, 354–357 (2016).
- 10.
Fry, A. M., Bayliss, R. & Roig, J. Front. Cell Dev. Biol. 5, 102 (2017).
- 11.
Hu, Z. et al. Science 341, 172–175 (2013).


text: The price of the treatment (personal drug rehab might be pricey, and an individual might have to seek out lower-Price or no cost dual diagnosis treatment centers. Calls to our common hotline may very well be answered by private treatment vendors. We may be paid a payment for internet marketing http://addictiondualdiagnosis31851.blogadvize.com/346947/addiction-dual-diagnosis-fundamentals-explained


text:
From Missi:
After Brianna's nap this afternoon she woke up and didn't know who I was. She asked me to be honest with her and tell her if I am really her mom. This of course was devastating for me but the more important issue is what happened during that hour nap. Is it a part of the brain healing? Is it a result of a medicine she is getting or a medicine that they have stopped? I am not sure but it scares me. Please pray for us!
Facebook: https://www.facebook.com/melissa.dixon.545


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Can any1 help with baked potatoes…?
Adjust the rack in your oven to the middle position and preheat oven. Rinse and scrub each potato under running water, as we will be eating the skins of these perfect potatoes. Dry each potato thoroughly. Pierce each deeply with a fork or sharp knife four times on each side at approximately 1″ intervals. This will allow steam to escape or the potato may explode during baking in your oven. NOTE: Wrapping the potato in aluminum foil will produce a soft skin (not crispy), but technically this is steaming rather than baking (as the moisture in the potato remains trapped) and the light, flaky texture will be missing. The texture of a steamed potato is entirely different from that of a perfect baked potato. Save yourself the trouble and expense of wrapping in aluminum foil and serve perfect baked potatoes. My suggestion is to never use aluminum foil when baking potatoes! For a soft skin, rub the potato with olive oil or butter over the skins. Bake on racks of oven until tender. NOTE: I like
Ultimate Jacket Preparation Time: 5mins Cooking Time: 60 – 75mins Tip: Lightly brush the potatoes with olive oil before cooking for really crunchy skins. One jacket potato (225g) contains more than half the daily recommended adult requirement of Vitamin C. Ingredients Slices of mushrooms Slices of ham, chopped Slices of onion Slices of red pepper Slices of tomato Grated cheese Directions Scrub the potatoes and place in a pre-heated King Edward oven at approx 200°C. Cook for approximately 1 hour until thoroughly cooked. Prepare the fillings in advance and store in a cool container until required. Make a meal of your jacket by cutting the cooked potato almost in half and piling in some slices of mushroom, pepper, ham, onion, tomato – or whatever takes your fancy! Top with a little grated cheese and replace in the oven for 2-3 minutes, or until the cheese has just melted. Those potatoes not served immediately can be transferred to the top display/storage area to stay hot until you are rea


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Finally, some interest from local media, as things just get worse!
An M&A target for years, Lions Gate needs to sell Starz or the whole company before things get even worse. Management's ineptitude on previous deals means there is a nice potential reward for new.
St Elizabeth Ann Seton Holiday Bazaar Tax ID# available at all times. st. elizabeth ann of Seton Women's club sponsors this event. Facilities are Parish Hall and adjac St. elizabeth ann seton holiday craft Bazaar in Plano, TX 75023 / EventLister.com: Craft ShowsCraft Shows, Arts and Craft, Craft, Craft Fair, High Craft, Festival, Fairs, Shows, Music Festivals, Market
Rehab Preston Call today. Drug Treatment Finders! Free Drug And Alcohol Rehab Near Me; Drug Rehab Centers In delaware; alcohol rehab Spartanburg Sc
J C PENNEY COMPANY INC : Stock Market News and Information | JCP| MarketScreener
He noticed things get worse when the line broke a few weeks ago, leaving his home without water.. "Either you go find some place to take a shower or you don't.. "When it finally comes back. For more information, please refer to the risk factors discussed in the documents we filed from some. things but memory was almost 27 points of that.
CAVA hosting happy hour for International Hummus Day CAVA Hosting Happy Hour for International Hummus Day Cofield Contents beauty show las vegas (ibs Grain side selections Tam.- .-en una gira privada Bauhaus, more correctly known as the.
Trust that Roman Catholic Church officials will do the right thing about allegations of sexual misconduct by members of the clergy is in question in many countries, not just the United States.
Jinger Duggar: Has She Finally Made Peace With Her Parents?!
· The saying goes that things have to get worse before they get better. But with Obamacare, things just keep getting worse-and then they get worse still. In.
Especially since she has said some pretty awful things about her husband, just to turn around and praise him online so the world doesn't know how many problems they have. I've always noticed this trend and it usually isn't wrong: Higher number of social media posts about relationship usually correlates with higher rates of unhappiness.
Types of Interest Groups. An interest group is an organization of people who share a common interest and work together to protect and promote that interest by influencing the government. Interest groups vary greatly in size, aims, and tactics. Political scientists generally divide interest groups into two categories: economic and noneconomic.
· He was just a person who enjoyed doing stuff so he collected the stuff he enjoyed. So my basement was filled with boxes of our life together. I did get rid of the things I nagged him about, but everything else lived in boxes. So I have recently started to open some boxes (most of my stuff) and pack some things to Good will.
Juana B Gutirrez Baby Birds in North Carolina Need Your Knitting Skills Baby Birds in North Carolina Need Your Knitting Skills. mentalfloss.com – BY Michele Debczak. The Carolina Waterfowl Rescue (CWR) shelters, feeds, and rehabilitates more than 1000 birds each year, many of which are babies that can't care for.Juana Beln Gutirrez, nacida en Durango, escribi literatura feminista radical contra el catolicismo, la corrupcin poltica, y las injusticias sociales durante el porfiriato. Daz la encarcel con frecuencia, pero a pesar de ello, continu transmitiendo sus ideas sobre la ilegitimidad de los lderes y partidos polticos.Vtg BANG OLUFSEN SPEAKERS PAIR SET #6503 – Still Sound Great! | eBay Results 1 – 48 of 4826. Vintage B&O Bang & Olufsen of denmark beogram 4002 linear turntable, As-Is. For sale are a pair of Bang & Olufsen Beolab 4000 speakers.. Speaker works great and has that B&O sound quality you are expecting. for a variety of set top boxes for a Bang & Olufsen television on a floor stand.


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I have an '02 Tracker and I've noticed if I have several accessories running, that my engine will start to sputter and come to the verge of stalling when I come to a stop. It happens if I have the heat/air and radio or charging my phone on together. What is the cause and/or remedy for this? I've changed the alternator a few yrs. back, but it still continued.
I've never had a vehicle stall because of overloaded accessories. It's probably a bad or dirty IAC (Idle Air Control Valve). How many miles on your engine?
Are your battery connections clean and tight with no corrosion? Get a cheap multimeter and read across the battery terminals. It should be 14.1 volts dc with the engine running and 12.5 volts or greater with engine off.


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Chandigarh: In an honour killing of a bride by her family in 2014, a sessions court in Haryana has sentenced seven people to life imprisonment.
The convicts were relatives of Amandeep Kaur of Dharbi village in Sirsa district, who was married to her neighbour Manmeet Singh in August 2014 against the family wishes.
Fearing threat to their lives, the couple had also sought the Punjab and Haryana High Court protection.
After staying in a shelter home initially, the couple moved to Manmeet's house.
In September, Amandeep was abducted by her family and her body was dumped at a village in Punjab.
Sirsa Additional District and Sessions Judge Chander Hass convicted Amandeep's brother Karan Singh, her uncles -- Mukhtyar Singh and Jagtar Singh -- and other relatives Vikas, Balbir Kaur, Prince Rani and Buta Singh.—IANS


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Edward Ervin "Mack" McElveen, III, 43, husband of Celeste Swain McElveen, died Tuesday, Sept. 13, 2005, at Duke University Hospital in Durham, N.C.
Born Sept. 18, 1961, in Kingstree, he was a son of Edward Ervin McElveen Jr. and Vivian Ruthven McElveen. He was a graduate of Salem Schools and Newberry College, a member of Hebron United Methodist Church and a farmer. Mack had two children a son Edward Ervin McElveen IV ; a daughter, Emily Swain McElveen, and a sister, Debra Lynn McElveen.
Libby Jackson (Ortmann) (1979)
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A view from across the river
21 Jun 2017
A view of the Monument from across the river. The tower belongs to St Magnus Church. The original London Bridge passed to the left of the tower, leading into Fish Street, with the fish market nearby to the east.
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