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#TDT Lea Tate…A day in the life of a Clinical Psychologist!
Being honest with what you want in life and going for it keeps you happy and satisfied.
1. What is your current job title and how did you decide on this career choice?
My name is Lea Tate and I am a clinical psychologist. I was raised in the Northstate and graduated from Shasta High School, Class of 1993. I attended the University of California, Berkeley and received my BA in Psychology with an informal emphasis in Military Affairs. After graduation in 1997, I attended the California School of Professional Psychology and earned my Masters Degree (1999) and my Doctorate in Psychology in 2001 with an emphasis in Cross-Cultural Psychology. I have been working in the field since that time. Currently, I work at the Department of Veterans Affairs as a clinical psychologist and as an associate administrator at Patients' Hospital of Redding. In my "spare" time, I have a small private practice where I perform disability evaluations on infants, adolescents and adults.
Making the decision to go into psychology was done when I was in the 5th grade. I was always the child who others went to for advice, family problems and problem solving. I enjoyed helping my friends and trying to figure out other ways to solve problems they were having. I continue to enjoy doing the same thing as an adult.
2. What types of qualities are important for this career choice?
Clinical psychologists have to be able to balance empathy with helping individuals achieve their goals. The qualities that are important in this profession are: empathy, great listening skills and the ability to establish rapport with clients. Connecting to clients no matter what is said in confidence is imperative. Putting aside your biases for certain issues (treatment of sex offenders, domestic violence perpetrators or victims, etc.) is important because it is difficult to help clients achieve goals if you have a preconceived idea about the goal. I have found that the best psychologist are ones that have great intuition!
3. What is a typical day or week in your position like? What exactly do you do?
I have several different hats in my current jobs:
At the Department of Veterans Affairs, I am the Local Recovery Coordinator. I work there part-time and I am responsible for ensuring Recovery Oriented Treatment is given to Veterans within the Northern California Healthcare System. Most of my days are spent on the telephone speaking with Veterans or training other VA mental health staff members on Recovery principles.
At Patients' Hospital of Redding, I am responsible for ensuring all departments are complying with state and federal hospital regulations. I work closely with the CEO of Patients' Hospital of Redding.
In my private practice, I typically see 4-7 patients on Fridays. I perform psychological testing on infants, adolescents and adults. Psychological testing can includes: determining intelligence quotient (IQ) scores, achievement scores, memory impairment assessments, development estimations, sexual deviant behavior levels, personality characteristics and neuropsychological functioning. It also focuses on cognitive, social, language and motor skill impairments
If you haven't notices, the common denominator of all of my current positions is that it involves interacting with people… You have to enjoy people!
4. What areas of study would you suggest for kids interested in your field? What path would you suggest?
When I speak to younger people who are interested in psychology, I always encourage classes in psychology, statistics, anthropology and sociology. Courses in history are helpful when working with clients of diverse backgrounds–if you have more knowledge about where the client comes from, rapport is easily established. This could be knowledge about the military, immigrants, various ethnic groups or socio-economic struggles. Connecting with a client can be the only difference between life and death as a result of suicide.
I would also suggest volunteering in an inpatient unit or county mental health. This is where I started. I worked at Shasta Psychiatric Hospital as a mental health worker while I was home from college in the summer. It is always been helpful for me to have the background of starting from the very bottom in mental health and working to the top. The most difficult patients are found in these types of facilities. You will immediately know if you have the personality to manage a successful profession in clinical psychology.
5. What is one piece of advice you would give to someone interested in your field?
If you pursue a career in psychology, commit to getting the doctoral degree. Having your Bachelor or Masters degree will not allow you to utilize the entire degree to the fullest potential. Since I received my degree in 2001, I've had so much flexibility in my career! It has led me to working in 2 of the largest healthcare organizations in the nation, working at Hurricane Katrina in a supervisory position, perform psychological testing, consult with lawyers on juror selection, teaching classes, profiling clients and testifying in court regarding psychological incidents. I would not have been exposed or included in most of these experiences without having my doctoral degree.
6.What is one myth buster you would like to share about your field?
All psychologists are NOT crazy!
7. Did you take a linear path to get here? If not, what were some pivotal points that changed your direction?
I made the decision in 5th grade to pursue a career in clinical psychology. I never deviated or considered anything else… I have always enjoyed school so going to college for several years was not a problem from me. Life changes all the time. You have to be prepared for highs and lows. Having a solid, successful degree and career has given me stability and options. As a woman, I think it's important to have options so that you never feel trapped. I definitely have "exercised" options throughout my life! Overall, I am happy with me career choice and very proud of my career history.
8. What personal qualities have helped you succeed in your career?
I believe that my top qualities that helped me succeed is 1) not being afraid to pursue something new, 2) honesty and 3)being genuine. It's always tempting to say "no, thank you" if someone asks you to do something different or foreign. I believe that getting involved, meeting new people and challenging skills is key to personal growth. Being honest with what you want in life and going for it keeps you happy and satisfied. Genuineness is important because people know when you aren't being sincere–you can't connect with anyone when they don't trust you!
I also have a pretty good sense of humor. My family laughs a lot together!
9. What do you most enjoy about your career?
The flexibility is the most enjoyable part of my career! My degree has allowed me to work in juvenile hall, testify in court, provide psychological profiles and work for 2 of the largest healthcare systems in the nation (Kaiser Permanente and Department of Veterans Affairs). I love the variety in my schedule!
10. What kind of work experience as a student would be the most beneficial for this career?
I always did a lot of volunteer work in high school and college in the psychology profession. Exposing yourself to difficult individuals occurs in psychology at some time or another… Working in an inpatient unit or a county mental health agency is great experience.
11. What education or training is required, if any, to reach your position?
4 years of undergraduate school, 4 years of graduate school, 1 year of post-doctoral internship. You must complete a dissertation to complete your doctoral program.
12. If you weren't in this career field, what other career would you be interested in? and why?
I think that I picked a great career option that works with my personality! I have never considered a different profession.
Website to find out more about you:


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This is the moment after first responders pulled a man from the quarry and put him into the back of an ambulance. He was rushed to local hospital. Condition at this hour is unknown. #ABC11 @raleighpolice pic.twitter.com/mpWtvvAu1f— Josh Chapin (@JoshChapinABC11) January 31, 2019
Wednesday night authorities were on the scene of a medical emergency on Duraleigh Road at the quarry between Glenwood Avenue and Edwards Mill.
The Wake County Sheriff's Office said the man was reported missing earlier in the evening by a friend who said they decided to go on an outing. Deputies said the missing man was later discovered in a body of water.
Number of fire trucks and @raleighpolice out here on duraleigh road. Trying to determine what happened. Ladder truck is in the air too. #ABC11 #BreakingNews pic.twitter.com/IvShx9ZaAk— Josh Chapin (@JoshChapinABC11) January 31, 2019
The man was found unconscious and not breathing, according to deputies. He was transported to UNC Rex Hospital.
This is a developing story, check back for updates.

subset: commoncrawl


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Eli Lilly entered two collaborations to study combination regimens for the treatment of cancer with anti-PD-1 therapies from Bristol-Myers Squibb and Merck & Co., the companies reported Tuesday. "Combination therapies will be key to addressing tumour heterogeneity and the inevitable resistance that is likely to develop to even the most promising new tailored therapies," remarked Richard Gaynor senior vice president of product development and medical affairs at Lilly Oncology.
In one Phase I/II trial, Eli Lilly will investigate its experimental TGF beta R1 kinase inhibitor galunisertib in combination with Bristol-Myers Squibb's Opdivo (nivolumab) in advanced glioblastoma, hepatocellular carcinoma and non-small-cell lung cancer (NSCLC). The companies noted that the collaboration will examine the hypothesis that co-inhibition of PD-1 and TGF beta negative signals may lead to enhanced antitumour immune responses versus inhibition of either pathway alone.
Eli Lilly will also conduct a Phase I/II trial assessing the investigational recombinant human IgG1 monoclonal antibody necitumumab together with Merck's Keytruda (pembrolizumab) in NSCLC. In addition, Eli Lilly will undertake a Phase I/II study examining Cyramza (ramucirumab) in combination with Keytruda in multiple tumours. Both studies are expected to begin this year. Further, Merck will conduct a Phase II study, which is currently enrolling patients, to investigate the combination of Keytruda and Eli Lilly's Alimta (pemetrexed) in first-line non-squamous NSCLC. Other terms of the collaborations were not disclosed.
Keytruda became the first FDA-approved PD-1 inhibitor following its clearance last year for advanced or unresectable melanoma, with Merck recently disclosing plans to seek expanded approval of the therapy for the treatment of patients with EGFR mutation-negative and ALK rearrangement-negative NSCLC. For related analysis, see ViewPoints: Could Merck & Co. deliver another stealthy US approval for Keytruda – this time in NSCLC?
Meanwhile, Opdivo was granted accelerated approval by the US regulator for the treatment of patients with unresectable or metastatic melanoma who no longer respond to other drugs. Bristol-Myers Squibb said Monday that a Phase III trial of the agent versus docetaxel in previously treated patients with advanced, squamous cell NSCLC was stopped early after meeting its endpoint (for related analysis, read ViewPoints: Bristol-Myers Squibb passes through key Opdivo checkpoint with Merck & Co. hot on its heels).
To read more Top Story articles, click here.
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The Chinese firm has confirmed the second release of their operating software is expanding into the market, making it a competitor to Android.
Consumer chief CEO Richard Yu made the announcement at Huawei's developer conference in Shenzhen, China, on Thursday (10.09.20).
It's looking likely that there will be a smartphone launch in 2021.
The beta version of the HarmonyOS 2.0 software that is currently used on smartwatches and TVs will be created by December to work on phones.
It's not anticipated tha there will be much difference in Android devices as it will likely be similar to the new EMUI 11 software that runs on top of Android.
Due to their ban in the US, Huawei can use Android on their smartphones, but they are unable to run Google's apps.
However, the company is working on its own AppGallery app store.
What's more, Huawei is launching the OpenHarmony project, which is offering developers the chance to work on their open-source version of the OS, like Android's AOSP.


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Quantitative proton MRS of Pelizaeus–Merzbacher disease
Evidence of dys- and hypomyelination
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Background: Pelizaeus–Merzbacher disease (PMD) is a rare X-linked recessive neurologic disorder caused by a mutation in the proteolipid protein (PLP) gene on chromosome Xq22. The associated depletion of PLP and severe reduction of other major myelin proteins results in dysmyelination. MRI reveals loss of T1 contrast between gray and affected white matter and T2 hyperintensities of white matter due to elevated water content.
Methods: In vivo proton magnetic resonance spectroscopy (MRS) was used to determine cerebral metabolite patterns in five patients with genetically proven PMD. Absolute metabolite concentrations were obtained in cortical gray matter, affected white matter, and basal ganglia and compared to age-matched control values.
Results: In comparison to age-matched controls, MRS of affected white matter resembled the metabolite pattern of cortical gray matter, as indicated by increased concentrations of N-acetylaspartate and N-acetylaspartylglutamate (tNAA), glutamine (Gln), myo-inositol (Ins), and creatine and phosphocreatine. Most remarkably, the concentration of choline-containing compounds was reduced. Parietal gray matter and basal ganglia appeared normal but showed a tendency for elevated tNAA, Gln, and Ins.
Conclusions: Magnetic resonance spectroscopy (MRS)–detected alterations are consistent with enhanced neuroaxonal density, astrogliosis, and reduction of oligodendroglia. These disturbances in cellular composition are in close agreement with the histopathologic features characteristic of dys- and hypomyelination. The proton MRS profile of Pelizaeus–Merzbacher disease (PMD) differs from the pattern commonly observed in demyelinating disorders and allows PMD to be distinguished from other leukodystrophies.
Pelizaeus–Merzbacher disease (PMD, MIM #312080) is an X-linked recessively inherited leukodystrophy caused by mutation of the proteolipid protein (PLP) gene on chromosome Xq 22. PLP encodes the two major myelin proteins of the CNS, PLP and its isoform DM 20. Gene duplication is the most common mutation in PMD, but missense mutations, insertions, and deletions have been identified as well. PLP mutations result in dysmyelination, a lack of properly formed myelin, and in this respect PMD is different from other leukodystrophies.1,2
Neuropathologic characteristics of PMD comprise i) a reduction or even absence of myelin sheaths in large areas of the white matter, predominantly in periventricular regions; ii) well-preserved neurons and axons; and iii) relatively preserved islets of myelin giving white matter a patchy "tigroid" appearance without active demyelination.3,4 A close correlation between the degree of dysmyelination and the clinical severity was found.3 The classification suggested by Seitelberger3,4 according to clinical and pathologic features is now largely reduced to two subtypes, the classic and connatal forms. Onset of the classic form is in the first year of life with muscular hypotonia, nystagmus, and delay in motor development. Nystagmus may disappear and spasticity and atactic-dystonic movements appear later. Slow developmental progress is often observed in the first decade of life, until relentless deterioration occurs with death in mid-adulthood. Tigroid dysmyelination is found in neuropathologic investigation. In contrast, patients with the rare and more malignant connatal form show little developmental progress. Severe neurologic symptoms include feeding problems, stridor, and marked spasticity resulting in multiple contractures. Epileptic seizures may occur. Patients usually die within the first decade of life. Pathologic examination shows complete lack of myelination in the entire brain.1–3
MRI studies of PMD show early on a diffuse hyperintensity or patchy changes of white matter on T2-weighted images and poor if any contrast between white and gray matter on T1-weighted images. It was proposed to divide the MRI changes into three subtypes according to extent and severity of white matter alterations, with the most severe type I indicating diffuse alteration in the hemispheres and corticospinal tracts.5
Proton magnetic resonance spectroscopy (MRS) has been used to characterize the neurochemical disturbances in a large variety of brain disorders in childhood and, in particular, identify a consistent pattern of active demyelination in a variety of leukodystrophies of known and unknown origin.6,7 Unfortunately, applications of proton MRS to PMD have led to conflicting results such as increased, decreased, or unchanged metabolite levels,8–16 which at least in part may be explained by technical limitations.
The purpose of this work was to determine absolute metabolite concentrations in cerebral gray and white matter of genetically proven PMD patients using fully relaxed, short-echo time single-voxel proton MRS. We hypothesized that quantitative proton MRS will allow us to distinguish metabolite abnormalities in PMD from the metabolite patterns of both controls and patients with other leukodystrophies. Part of this work was presented previously in abstract form.17
Five boys with clinical and MRI features consistent with PMD were included in this study. Their ages at MRS ranged from 7 months to 6.8 years (mean ± SD 3.5 ± 2.6). Table 1 summarizes their clinical features. The diagnosis of PMD was confirmed by mutation analysis of the PLP gene in all five patients. Patients 2 and 3 were investigated three times, with follow-up MRS performed 1 to 3 years after the initial examination. In all patients, MRI revealed diffuse white matter signal alterations in the hemispheres and corticospinal tracts, according to subtype I as defined by the classification proposed recently.5
MRS and MRI.
Written informed consent was obtained from the parents. MR examinations were performed at 2.0 T (Siemens Magnetom SP4000 and Siemens Magnetom Vision, Erlangen, Germany) using the standard imaging head coil or, for children with a body weight less than 10 kg, the extremity coil (Patients 1 and 3, first examination). Volumes-of-interest (VOI) for single-voxel proton MRS were selected from T1-weighted images (three-dimensional fast low angle shot) and T2-weighted images (fast spin echo). Locations were placed in parietal gray matter (8 to 12.5 mL in a paramedian position), affected white matter (4 to 6 mL in parieto-occipital and frontal lobes), and basal ganglia (4 to 6 mL) as indicated in figures 1 and 2. Fully relaxed, short-echo time proton MR spectra were recorded using a STEAM (STimulated Echo Acquisition Mode) localization sequence (TR/TE/TM = 6,000/20/30 msec for Magnetom SP4000, TR/TE/TM = 6,000/20/10 msec for Magnetom Vision, 64 accumulations) as described previously.18
Data analysis.
Absolute metabolite concentrations (expressed in mmol/L VOI) were obtained with LCModel, a user-independent fitting routine, which is based on a library of model spectra of individual metabolites.19 Metabolites routinely identified by this procedure are the neuroaxonal markers N-acetylaspartate and N-acetylaspartylglutamate (tNAA),20,21 creatine and phosphocreatine (tCr) involved in energy metabolism,22 choline-containing compounds (Cho) connected to membrane turnover,23 the glial (astrocytic) marker myo-inositol (Ins),24,25 the excitatory neurotransmitter glutamate (Glu) and its amidated form glutamine (Gln), and lactate as an indicator of nonoxidative metabolism. Absolute metabolite concentrations from patients with PMD were compared to those of a group of age-matched controls specifically assembled from our subject pool reported previously.26 Statistical evaluation was performed using a two-tailed Student t test assuming unequal variances with a significance level of p < 0.05.
MRI typical for PMD is shown in figure 1 for Patient 4. At the age of 2.9 years, the abnormal stage of myelination is readily observable. In T1-weighted MRI (figure 1, A and C), the contrast between gray and white matter is missing, and the thin corpus callosum is hardly myelinated. Hyperintensities in T2-weighted images (figure 1, B and D) are consistent with lack of normal myelin in white matter, which reverses the normal T2 contrast between gray and white matter at this age. Despite marked alterations in myelination as indicated by MRI, the metabolite patterns detected by MRS appear comparatively normal. However, whereas cortical gray matter and basal ganglia (figure 1, A and D) reveal the familiar metabolite pattern of healthy controls, MRS of affected parieto-occipital and frontal white matter (figure 1, B and C) unravels clear disturbances that are most easily recognized by the abnormally low Cho signal relative to that of tCr. Parallel to T1-weighted MRI, the resulting metabolite pattern in white matter resembles the MRS characteristics of cortical gray matter.
These observations are confirmed by a quantitative analysis of absolute metabolite concentrations as summarized in table 2. When averaged across all patients and compared to age-matched controls, affected parieto-occipital white matter shows a significantly altered metabolite pattern comprising increased concentrations of tNAA (+29%), Gln (+50%), Ins (+89%), and tCr (+30%) as well as decreased Cho (−17%). Even though statistically not significant, a tendency for elevated Glu was observed (+23%). In addition, the proton MR spectra of affected white matter reveal much smaller resonance line widths than those of age-matched children with normal myelination.
Although relatively normal concentrations are found in cortical gray matter and basal ganglia, the data show a similar tendency as in white matter for elevated tNAA (+14% in cortical gray matter and +12% in basal ganglia), Gln (+26% and +9%), and Ins (+20% and +39%).
Elevated Lactate was observed only once in white matter of Patient 1, yielding 3.3 mmol/L as compared to control values less than 1 mmol/L.
Follow-up examinations of Patient 3 are shown in figure 2. Over a period of 3 years, the spectral pattern and absolute concentrations of metabolites in parieto-occipital white matter remained largely unchanged.
In five patients with genetically confirmed PMD, a neurochemical assessment by proton MRS revealed largely unchanged metabolite concentrations in cortical and subcortical gray matter. In contrast, affected white matter as identified by MRI was characterized by a reduction of Cho as well as elevated concentrations of tNAA, Gln, Ins, and tCr.
Cho mainly represents contributions from phosphorylcholine and phosphorylethanolamine as precursors for membrane synthesis as well as from the corresponding membrane degradation products glycerophosphorylcholine and glycerophosphorylethanolamine.23 The elevation of Cho in demyelinating leukodystrophies is attributed to increased membrane turnover. In our patients, the reduction of Cho (−17%) in white matter may be assigned to the severe reduction of choline-containing myelin proteins and lipids caused by the lack of normally functioning oligodendrocytes.
MRS measurements of tNAA have been validated as an axon-specific monitor of white matter.21 A close correlation between neuronal loss and a decrease in tNAA has been demonstrated in various cerebral disorders.27 Marked elevation of tNAA as detected by MRS is highly characteristic of Canavan disease due to deficiency of aspartoacylase activity. The moderate increase of tNAA (+29%) observed in our patients with PMD probably reflects the elevated density of axons in white matter lacking the oligodendrocytic tissue and normal myelin sheaths between axons. Even though statistically not significant, the tendency for elevated tNAA, Gln, and Ins in cortical and subcortical gray matter hints at a similar effect in cortex and basal ganglia. In fact, the occurrence of an enhanced neuroaxonal density is further supported by the simultaneous observation of slightly increased levels of the excitatory neurotransmitter Glu (+23% in white and +12% in cortical gray matter), which is synthesized in neurons.
Ins is a key precursor of membrane phosphoinositides and phospholipids and involved in cell membrane structure.28 The Ins signal detected by MRS reflects free Ins,24 which has been recognized as the most important nonnitrogenous organic osmolyte in mammalian brain tissue.29 For proton MRS of the brain, Ins has been validated as a glia-specific marker with particularly high concentrations in astrocytes.25 Therefore, the increase of Ins (+89%) in affected white matter is consistent with an astrocytic proliferation. This notion is further supported by the observed increase of Gln (+50% in white and +26% in cortical gray matter), which is mainly present in astrocytes.
tCr is involved in energy metabolism and a constituent of both neuronal and glial cells. In rats, higher tCr concentrations have been found in astrocytes than in neurons.22 Accordingly, the combination of a high neuroaxonal density with an increased number of astrocytes should result in a higher concentration of tCr, which is indeed observed (+30%).
Taken together, the pronounced metabolite alterations in PMD white matter are in line with enhanced neuroaxonal density, astrogliosis, and reduced oligodendroglia. These changes in cellular composition are in close agreement with the histopathologic alterations typically seen in PMD. The histologic hallmark that is the marked reduction or even complete lack of myelin results in a higher concentration of axons, while areas devoid of myelin show paucity or absence of oligodendroglia and a diffuse moderate proliferation of astroglia.30 Whether the cerebral cortex is spared by the disease as previously suggested30 remains an open question. It deserves further investigation in view of the enhanced neuroaxonal and astrocytic density (elevated tNAA and Ins) found in both cortical and deep gray matter.
The metabolite abnormalities in PMD are complemented by the unexpected finding of markedly reduced resonance line widths in proton MRS of white matter. Because the spectral resolution is directly proportional to the magnetic field homogeneity, smaller line widths indicate a better homogeneity. In terms of structure, this may be related to the absence of myelin sheaths that allow for a more homogeneous tissue composition with markedly reduced structural boundaries than in normal white matter. In addition, the lack of oligodendrocytes may contribute to the field homogeneity as oligodendrocytes contain a considerable amount of paramagnetic iron.31
Recent MRS studies of patients with PMD yielded conflicting results despite the fact that PMD was genetically proven. Apart from the possible influence of differences in patients' age or disease stage, the reported increases and decreases in ratios of Cho/tCr,11–13 decreases in tNAA/tCr8,9,11–13 and tNAA/Cho,8,12 increases in Ins/tCr13 as well as decreases and increases in the tNAA concentration9,15 may reflect the use of different techniques ranging from chemical shift imaging to single-voxel MRS. Furthermore, the discrepancies imbed the uncertainties introduced by the use of ratios of T1- and T2-weighted resonance intensities, which are sensitive to putative alterations of T1 and T2 relaxation times even in the absence of a true metabolic change. Here, the observation of a reduction of the Cho concentration emerges as a novel spectroscopic hallmark of affected white matter in PMD. So far, this finding has only been reported based on metabolite ratios in a single patient with genetically confirmed PMD32 and in two patients with connatal PMD but an absence of a mutation of the PLP gene.14
The metabolite abnormalities detected by in vivo proton MRS in white matter of patients with genetically proven PMD comprise enhanced neuroaxonal density, astrogliosis, and reduced oligodendroglia. This profile clearly differs from the spectral alterations seen in leukodystrophies with predominant demyelination. MRS of white matter in demyelinating disorders like adrenoleukodystrophy is characterized by a marked reduction of tNAA, indicating loss of vital neuroaxonal tissue, in conjunction with elevation of Cho and Ins, indicating demyelination and glial proliferation.33 Nevertheless, the cellular alterations demonstrated here are unlikely to be specific for PMD. Instead we presume that other conditions with hypo- and dysmyelination will present with a similar metabolite profile. In fact, hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) revealed a corresponding metabolite pattern except for a normal Cho level, which is tentatively ascribed to compensation by strong glial proliferation.34 Further studies of hypomyelinating disorders are needed to validate the common features of hypomyelinating disorders. These investigations should include patients with the recently identified PMD-like disease caused by mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6).35
The authors thank Prof. Dr. O. Boespflug, Faculté de Médicine, Clermont Ferrand, for molecular analyses of the PLP gene and Drs. S. Dreha-Kulaczewski and G. Helms, Bereich Humanmedizin, Georg-August-Universität Göttingen, for help regarding data analysis.
Dr. Pouwels was supported by a fellowship of the European Community (ERBCHBGCT 940722) and Dr. Dechent by a grant from the VolkswagenStiftung.
Disclosure: The authors report no conflicts of interest.
Received March 11, 2005. Accepted in final form May 23, 2005.
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Inoue K. PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Neurogenetics 2005;1:1–16.
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Seitelberger F. Neuropathology and genetics of Pelizaeus-Merzbacher disease. Brain Pathol 1995;5:267–273.
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Seitelberger F Pelizaeus-Merzbacher disease. In: Vinken P, Bruyn G, eds. Handbook of clinical neurology. Leucodystrophies and poliodystrophie. Amsterdam: North-Holland, 1970:150–202.
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Hanefeld F, Brockmann K, Dechent P. MR spectroscopy in pediatric white matter disease. In: Gillard JH, Waldman AD, Barker PB, eds. Clinical MR neuroimaging. Diffusion, perfusion and spectroscopy. Cambridge: Cambridge University Press, 2005:755–778.
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Frahm J, Hanefeld F Localized proton magnetic resonance spectroscopy of brain disorders in childhood. In: Bachelard HS, ed. Magnetic resonance spectroscopy and imaging in neurochemistry. New York: Plenum Press, 1997:329–402.
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Bonavita S, Schiffmann R, Moore DF, et al. Evidence for neuroaxonal injury in patients with proteolipid protein gene mutations. Neurology 2001;56:785–788.
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Garbern JY, Yool DA, Moore GJ, et al. Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation. Brain 2002;125:551–561.
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Pizzini F, Fatemi AS, Barker PB, et al. Proton MR spectroscopic imaging in Pelizaeus-Merzbacher disease. AJNR Am J Neuroradiol 2003;24:1683–1689.
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Takanashi J, Inoue K, Tomita M, et al. Brain N-acetylaspartate is elevated in Pelizaeus-Merzbacher disease with PLP1 duplication. Neurology 2002;58:237–241.
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Pouwels P, Hanefeld F, Frahm J. Proton MRS in Pelizaeus-Merzbacher disease. Neuropediatrics 1997;28:355–356.
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Frahm J, Michaelis T, Merboldt KD, Bruhn H, Gyngell ML, Hänicke W. Improvements in localized proton NMR spectroscopy of human brain. Water suppression, short echo times, and 1mL resolution. J Magn Reson 1990;90:464–473.
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Cheng LL, Ma MJ, Becerra L, et al. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci USA 1997;94:6408–6413.
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Friede RL. Developmental neuropathology, 2nd ed. New York: Springer, 1989.
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van der Knaap MS, Naidu S, Pouwels PJ, et al. New syndrome characterized by hypomyelination with atrophy of the basal ganglia and cerebellum. AJNR Am J Neuroradiol 2002;23:1466–1474.
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Disputes & Debates: Rapid online correspondence
- Reply to Khan
Submitted October 27, 2005
- Peter Dechent, MR-Forschung in der Neurologie und Psychiatrie, Humanmedizin, Georg-August-Universitaet, 37099 Goettingen, email@example.com
- F. A. Hanefeld, K. Brockmann, P.J.W. Pouwels, B. Wilken, and J. Frahm
- Quantitative proton MRS of Pelizaeus–Merzbacher disease: Evidence of dys- and hypomyelination
Submitted October 27, 2005
- Omar A. Khan, Wayne State University School of Medicine, 4201 St Antoine; 8D-UHC, Detroit, MI firstname.lastname@example.com
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text: Fairfax County's restaurants are open for business as part of the Forward Virginia: Phase Three reopening strategy. While they may continue offering to-go and pick up options, access to their indoor and outdoor seating areas (where available) may require a reservation. Please check individual restaurant websites and social channels for operating status, additional safety measures, hours, and additional information.


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Tamahere Lions Best Artisan Market - December
WhenSaturday 12 December 2020 9:00 AM - Saturday 12 December 2020 1:00 PM
WhereTamahere Community Hall
21 Devine Road
Tamahere Show in Google Maps
Contact Details
Cost and BookingFree
Over 50 indoor and outdoor stalls: Gifts, crafts, food, coffee, clothes, some produce, jewellery, candles, bouncy castles, art, photography… you want it and you will be able to find it.
We will also be collecting good quality toys, books and clothes for Kids in Need Waikato recycle glasses and wine bottle tops/can tabs for kids can.
Come on down, join the fun - all proceeds to the local, national and international community.


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Having a "crucial conversation" with a nurse is a delicate balance between protecting clinical standards, providing a teaching moment, and… Read more »
What Does Ember Med Mean for the Healthcare Industry?
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Hope; it holds the potential to drive a man insane, feeding on any optimism one possesses, building up and growing larger until reality tears it down. However, It can also be a marvelous state of mind, allowing one to do things they never thought possible. Without the hope that inspired a man to sail past the edge of the world, a vastly-uncharted land would not have been found, even if it was thought to be India at the time. Without the hope that pulled on the heartstrings of the settlers of this new land, the United States may not truly be the land of the free. Within a mass amount of calculations and scientific theory, it was hope that drove human beings to set foot on a celestial object that once could only be viewed from hundreds of thousands of miles away. This theme of hope flourishes through the pages of Lois Lowry's novel The Giver, illustrated through the tone and symbols that appear through the characters experiences.
Lois Lowry struck emotional tones and ideas, using descriptive situations to allow the reader to connect to the scenarios Jonas, the protagonist, found himself in. A bitter tone reveals itself as the story unfolds into a black-and-white world, quite literally. Jonas was the only one that was able to see color after becoming the Giver. "They were satisfied with their lives which had none of the vibrance his own was taking on. And he was angry at himself, that he could not change that for them." The author almost uses some sort of foreshadowing, saying that Jonas is not able to accomplish his wish of sharing his wonderful gift. This not only shows hope within Jonas himself, but also brings out hope in the reader. The tone forces the reader to place themselves where Jonas is; the only person that has the knowledge of the past, experiencing everything and carrying the memories on, from the awesome to the awful. "The worst part of holding the memories is not the pain. It's the loneliness of it. Memories need to be shared" (Lowry 154). The tone represents the pain and anguish Jonas is experiencing, and the hope that one day the world might be as it was before. He had to carry the weight of all of mankind that came before him, he alone was burdened with the emotions and knowledge from the past. After being exposed to the real world, there was no way that he could go back, and he questioned how those around him could really live without the full experiences that come with being human.
The aspiration of sharing the memories with the world is not the only source of hope, but the small baby Gabriel. Being one of many symbols to appear throughout the work, Lowry signifies the theme of hope through baby Gabriel. As the world around Jonas becomes more and more complex and intricate, his hope for Gabe to experience the full wonder of the world expands and thrives. "'Gabe?' The newchild stirred slightly in his sleep. Jonas looked over at him. 'There could be love'" (Lowry 128). Not even capable of expressing the emotion of love, the society around Jonas is blind to the feelings he in experiencing. Just as Jonas was reborn when the memories of the past were shown to him, Baby Gabriel is fresh to the earth, untouched. The main motivation quickly becomes Gabe, for he is a sign of new hope in the world and the potential of change. "'Things could change Gabe," Jonas went on, "Things could be different. I don't know how, but there must be some way for things to be different'" (Lowry 128). Gabe changed Jonas's outlook on the whole entire situation. Before, there was no hope in bringing all the wonder of the former world back to civilization, but Gabe brought a new ambition. The child was new to the world, he had not been exposed to the blandness of controlled life that everyone else in the community experienced. He was an opportunity to start anew.
As Lois Lowry illustrates through symbols and tone, the theme of hope appears countlessly throughout The Giver. Although hope has its ups and downs, it can bring about great things. It has the potential to motivate oneself while all odds look down upon them. It can reveal and enlarge any small opportunities of light in a world of darkness. It allows one to take the leap, ignoring the chance of failure or consequences that come with it. Without hope, one could not truly live.
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Elements with tag european commission
EU Biodiversity strategy ignores fisheries management achievements - The strategy puts at risk European food production
Fishing Industry welcomes EU support to overcome the socio-economic turmoil caused by the COVID-19 outbreak
EU Fishing Industry welcomes European Commission's proposal as a first measure to mitigate the impact of the COVID-19 Crisis. Additional Funding must now be provided.
Europêche presents main points of concern for the fishing sector at a decisive moment for its future
EU fishing sector demands realism and flexibility in face of the imminent arrival of the "perfect storm"
Fishing industry disappointed over European Commission decision to maintain the Birds and Habitats Directives unchanged
EUROPECHE and EAPO call upon EU Member State Ministers to decide on TACs and Quotas 2017 taking into account the integrity of the EU fisheries
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Store Officer
Paradise Placement Consultancy
Job Description:
Hiring for one of the reputed leading Plastic Molding Company in India
Position: Store Officer – 1
Experience – Minimum 3 to 4 yrs in Manufacturing Industries.
Qualification – B COM/ M COM
The salary will be – 16000 to 18000 (CTC).
If you are interested kindly send your updated CV with applied subject
Paradise Placement Consultancy
Sheetal Capital" Second Floor, Shop.No.11, Opp. YSK Hospital, Chistiya Chowk, N-5, CIDCO, Aurangabad
E-Mail: email@example.com
Contact: 7249840333 / 9765567505
Company Profile
We are one of the reputed leading Plastic Molding company in India. Being in the field for over more than two decades we have gained vast experience by handling various complicated jobs and have thereby become a name to be remembered first for any critical product.
And talking in terms of certifications we are an ISO 9001:2008 certified Company.
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- Interested Candidates are requested to apply and inform your interest in this job.
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Every now and again, I find that I need to have a look at, or even edit, the local group policies on a computer. To do this, we use a tool called Local Group Policy editor. Here's how to start it:Leave a Comment
Tag: GPEdit
I've been annoyed that I've not been able to change the default Save As/Open locations, as well as changing the 5 options I get on the Places Bar. Here's what it looks like default:Leave a Comment
Have you ever returned to your computer only to find it having restarted, and all of your data gone? For a myriad of reasons, I keep my computers running continuously for a long time at a time. This makes this insistence on a reboot not only annoying, but in its extremes, it can actually make me lose work. To prevent this, I have disabled the auto-reboot, and I am no longer annoyed with repeated requests for reboots.Leave a Comment


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Frontline files complaint against DHT
DHT's Board has not agreed to halt the restrictions imposed by the poison pill or to commence negotiations with Frontline on its proposed offer.
Accordingly, Frontline has filed a complaint in the Marshall Islands (where DHT is incorporated) to immediately enjoin portions of the unfair transaction documents into which DHT has entered that would permit BW Group to establish 45% ownership of DHT (even as other shareholders cannot exceed 10%).
Frontline has also sought an injunction as to the poison pill and other related anti-takeover defenses DHT has erected.
Frontline today dismissed a related action it brought in New York, where the court previously held it did not have jurisdiction over DHT or BW Group. ■


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Hanley Sustainability Institute
HSI grad assistants kick off office ecology project to help campus offices' sustainability
By Mark Gokavi
Hanley Sustainability Institute graduate students Tess Isemann and Lauren Wolford are working with the Center for Leadership on a pilot project to increase awareness of everyday habits in University of Dayton work spaces that they hope will lead to sustainability improvements.
The duo examined procurement, catering and work food habits including the use of paper plates or one-time plastic bags/utensils, office plants, transportation to work and using powerstrips that get turned off at the end of the workday, among other items. They plan to compile and present their findings early this semester.
"We're not looking to change up everything that you're doing," Isemann said. "We're looking to make your (office's) current way of life better for the planet and people. Our team is able to identify where the operations of the office are now, and develop strategies to help the office meet goals, which ultimately help the university meet our climate commitments."
April Mescher, strategic partnerships and marketing director at the Center for Leadership, jumped at the opportunity for the Center for Leadership to be the case study after a "Lunch and Learn" put on by HSI.
Hosting more than 100 senior executives, emerging leaders, front-line supervisors and professionals from corporate, non-profit, education and government organizations weekly in their space, made it the perfect spot to pilot the program, according to Isemann and Wolford. There were plenty of opportunities in a controlled space to observe and monitor everything from how the space is performing, team operations and preparations, printed items and catering, and food waste.
"By nature, I am always looking to ensure we are leaving the planet a better place, anyway," Mescher said, who added that Isemann told her, "You know your team is already doing a lot of the right things, but I think that we could offer some suggestions and alternatives."
Mescher said she hopes other UD offices take advantage of the program.
"I think we should be leveraging these types of opportunities to make us stronger and more sustainable," she said. "It's painless. They are bright people that will help us all be better. It's really a zero effort to host the audit on the office that's being assessed. You need to allow them (to work) and be open to their feedback."
Though the center's assessment isn't finished, Isemann said, "We were actually able to celebrate a lot of really good best practices that they are already accomplishing." Wolford added, "The pilot of this program went very well, and we're looking forward to adding on a few more offices in the spring semester."
This office ecology project piggy-backs the HSI's Green Office Initiative that offered certifications to recognize best practices in work spaces. The Green Office Initiative was part of the Sustainability Tracking, Assessment & Rating System (STARS) effort, which ultimately resulted in the University of Dayton earning a gold rating from the Association for the Advancement in Sustainability in Higher Education (AASHE).
Wolford and Isemann hope other students pick up the baton from them beyond this semester and that their initiative morphs into office "ambassadors" training others on best practices.
"Lauren and I had the bigger dreams of, well, what if the employee engagement was to make their offices more sustainable? Then, you'd hit two birds with one stone," Isemann said. "You'd have employee education and you'd have peers teaching peers how to be more sustainable."


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Conforming Versus Jumbo Loans A conforming loan is any loan amount of $417,000 or less. A jumbo loan is any loan greater than $417,000. Generally speaking, jumbo loans will have slightly higher interest rates than a conforming loan.
Who Has Best Mortgage Rates National 30 Year Fixed Mortgage Rates 30-Year Fixed Rate Mortgage Rate Nears Two-Year Low – Freddie Mac – 30-Year Fixed Rate Mortgage Rate Nears Two-Year Low June 6, 2019. While the drop in mortgage rates is a good opportunity for consumers to save on their mortgage payment, our research indicates that there can be a wide dispersion among mortgage rate offers. By shopping around and getting a single additional mortgage rate quote, a borrower can save an average of $1,500.Average Us Mortgage Rate Mortgage Rate Daily Chart Mortgage Marvel: Mortgage Rate Trends – Use our interactive mortgage rate trend graph to compare mortgage rates for multiple. Others provide daily data, but the data is from an inconsistent group of .US average mortgage rates fall; 30-year loan at 4.75 percent – Mortgage giant Freddie Mac said Thursday that the average rate on the benchmark 30-year fixed-rate mortgage dipped to 4.75 percent from 4.81 percent last week. The key rate stood at 3.94 percent a year ago. The rate on 15-year fixed-rate loans declined to 4.21 percent from 4.25 percent the previous week.mortgage rate history: 1971 to Today. Homebuyers who have recently borrowed fixed-rate mortgages have benefited from interest rates at historical lows. After reaching a high of nearly 19% in 1981, mortgage rates have steadily declined and remained in the low single digits.
In recent months, the average annual percentage rate (APR) % for a jumbo mortgage actually be in-line to or below with mortgage interest rates for conventional mortgages. In fact, it's not uncommon to see a lower APR for a jumbo mortgage.
Mortgage rates held. the data and trade relations, the more rates could rise, while weaker data and trade wars will lead to new long-term lows. Rates discussed refer to the most frequently-quoted,
Interest Rates 20 Year Fixed 20-Year Fixed mortgage rates 2018. compare Washington 20-Year Fixed Conforming Mortgage rates with a loan amount of $250,000. Use the search box below to change the mortgage product or the loan amount. Click the lender name to view more information. Mortgage rates are updated daily. Advanced.
Conventional Versus Jumbo Loan What Amount Is A Jumbo Loan In Texas As an easy example, if 30-year mortgage rates drop.250 %, Since jumbo loans are larger than conventional mortgage loans, any money you can save on rates is a big deal. For example, just a half a point difference in interest rates for a $700,000 jumbo loan at.
FHA Loans vs. Conventional Loans. It may not always seem clear whether to apply for a FHA loan or conventional loan. FHA loans have typically been known as loans for first-time homebuyers, filled with extra paperwork and complexity since it's a government-insured program. But borrowers can use multiple fha loans for purchasing or refinancing a home loan.


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Title: Sonic Spinball
Platform: Game Gear
Region: PAL (Region Free)
Condition: Good, Box a bit worn, Incl manual + Inner tray. Cart in protective case
Sonic The Hedgehog spins into pinball pandemonium! Dr. Robotnik's latest robotic-creation factory is the Veg-O-Fortress, a volcanic island fueled by the Chaos Emeralds and protected by the Pinball Defense System. Strap on your Power Sneakers for all-new Sonic moves! Sonic rockets into space, spring launches from levers and balls up for a high-altitude bounce! Multi-round zones of wild Sonic action through glittering caverns, oozing toxic pools and boiling lava pits!


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STOCKHOLM—A riot broke out on Friday in the southern Swedish town of Malmo, where at least 300 people had gathered to protest against anti-Islam activities, police said.
Protesters were throwing objects at police officers and car tyres had been set on fire, a police spokesman said. Earlier in the day, a copy of the Quran had been burned in Malmo by anti-Islam activists.
"We don't have this under control but we are working actively to take control," the spokesman said.
"We see a connection between what is happening now and what happened earlier today," he said.
The demonstrations had escalated in the same place where the Quran had been burned, the spokesman said.
Daily Aftonbladet said several anti-Islam activities had taken place in Malmo on Friday, including three men kicking a copy of the Quran between them in a public square.
The anti-Islam protests occurred after Rasmus Paludan, leader of Danish ethnonationalist, anti-immigration political party Hard Line, had been denied permission to have a meeting in Malmo and was stopped at the Swedish border, according to the newspaper.
The Epoch Times contributed to this report


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Classic WoW: Is Multiboxing Good for the Game?admin June 30, 2020 20 Comments
A very diving subject today, is multiboxing good for Classic WoW? Let's take a look into the wild world of being your own raid team.
Music used, In order:
Dun Morogh Music:
Shattrath Music:
Outro – A small track from Winterspring, "Winterspring 5"
Clips Used in order:
Classic WoW 40 man multibox show!
WoW Vanilla BWL40 – Final Boss Fight Nefarian Multiboxing 39 accounts 1.12.1
Vegas TheMultiboxer
WoW – Multiboxing 5 Hunters – Arathi Basin Battleground
5-man Multibox Dungeon Training for World of Warcraft Classic
Multiboxing on Warmane Private WoW Server
Broim Broimsan
WOW Classic: Multiboxing 4 Mages [PvP]
Hardcore Scape
Multibox – WoW Classic – BRD – 80k xp/hour – 95 gold/hour – lvl 55
#wowclassic #wow #warcraft #classicwow #multibox
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Gaming Email Posted on June 30, 2020 at 1:48 am
You can buy wow tokens , a multiboxer who bought 8 accounts only paid for BFA (first month is free) the monthly sub for the rest of these accounts life is by wow tokens he wont pay real money + he can buy wow tokens and use them as real money only useable in Battle.net so he can buy anygame or any ingame shop thing he wants from (Gold) that he farmed ingame.
So basically Blizzard is having fun right now cuz everyone is buying new accounts for multiboxing it is a real problem now u can see them every where in the game from old areas to new areas they are every where don't forget that multiboxing played a huge part in increasing the gold cap in the game alot of people are new to world of warcraft and they have no problem playing it like this cuz they did not try the old wow WOD MOP CATA etc when it was really hard to get 500k now more than 70% of the players new and old have more than 300k gold 🙂
blizzard gona feel the pain of this decision (not banning multiboxing) in the future when no one gona pay real money not only in wow but in every activision / Blizzard game (anything that available in the BT store) that gona effect us world of warcraft fans cuz they wont have money to pay there employs and the old story where every employ gona leave gona happen again 🙂 i really wish they start think properly and let us play the game i cant do a quest or gear up without waiting more than an hour for the mobs to spawn and that boomy druid tag them -.- even if u change realm or phase out guess what another multiboxer 8 boomys farming more yes friends it is that bad they are everywhere while i am writing this i am beside a boomy horde in azuna right now :3
Electris Posted on June 30, 2020 at 1:48 am
So multiboxer will kill you for their personal gains but the game isnt fair any way so you shouldnt feel bad about it ! also they will make x4 the gold within a week your avarage joe makes in a month but hey who cares about em? They will also have advantage over on black market 😉 good luck ceompeting for an item a multiboxer wants . MOST importanty they will make cool shows in capital city but hey who cares if they are makin the zone lag ,they have pcs to entertain them selfs at least am i right?
Yung Cub Posted on June 30, 2020 at 1:48 am
CrooksCrooked Posted on June 30, 2020 at 1:48 am
the level of mental gymnastics mulitboxers have put themselves through to be able to think its okay or even good for the game is honestly disheartening. one player should have the power of one player.
Leprosu Gnome Posted on June 30, 2020 at 1:48 am
WillE is a multiboxers, what a surprise
Leprosu Gnome Posted on June 30, 2020 at 1:48 am
Multiboxers are cheaters and ruin the game.
LightWrathme Posted on June 30, 2020 at 1:48 am
As a multiboxer myself on Retail, I ofc enjoy multiboxing but I do see that it can be abused. I think that we should look more at the power of an individual when assessing if an instance of multiboxing has gone too far.
I don't exactly see a problem with someone running their own raid should they want to do that on their own. But see it as a problem when they cause disruption that is un-natural and against the spirit of the game, such a causing lag or camping grave yards for an excessive amount of time.
Andrew Byrnes Posted on June 30, 2020 at 1:48 am
The only people that dislike it are the ones that aren't smart enough to set it up.
Questionable Object Posted on June 30, 2020 at 1:48 am
I don't like it.
Group activities should be done in a group with other people not a bunch of virtual machines.
altrario Posted on June 30, 2020 at 1:48 am
How about you trying to farm mats in nazjatar to level your professions and not being able to see a single node because there are 5 stacks of 10 druids flying around in every shard of the game? Doesn't that count as gameplay disruption? This has been going on for months now.
Raven EyeCandy Posted on June 30, 2020 at 1:48 am
The amount of cry babies in the comments is just down right sad
Sneebs Posted on June 30, 2020 at 1:48 am
Multiboxer confirmed
B0BtheNinja Posted on June 30, 2020 at 1:48 am
I got kicked from a BG because a Multiboxer didn't like me.. then he reported my account from all their accounts.. and he was working for a company that hires people to do nothing but multi box and said he was going to put me on a list so that the other multuboxers at their company would also report me if they ever saw me… f multiboxers, botters, and BG afkers…
Pettsson Posted on June 30, 2020 at 1:48 am
If it did not require multiple subs it would never be allowed.
Allzombifood Posted on June 30, 2020 at 1:48 am
I dont care as long as it's used for fun.
For example:
This guy is being salty in chat, so you tell him by a tunnel: stop yelling at people or I will call my brothers!
He tells you: Do it!
Then 4 guys perfectly synchronized jump from the roof, landing right behind you.
RavidGames Posted on June 30, 2020 at 1:48 am
$$$$$$$$$$$$$$. This is why multiboxing is fine. There ftfy
Ben Schwarz Posted on June 30, 2020 at 1:48 am
No its not i fucking hate them.
Akow Posted on June 30, 2020 at 1:48 am
I never had a problem with it until they started to mass raid PVP. I que for a PVP battleground, just to end up with 1 or 2 people multi-boxing and one shoot anyone. Then they camp rare mobs in Panda land for xp boost. I could go on :/ another reason why I left the game.
BiggCarl Posted on June 30, 2020 at 1:48 am
real multiboxer don't sell accounts… those are gold/account sellers that are "USING" multiboxing. They would do it with bots just as easily. Multiboxers value our accounts and time we put into them and want to use them and would never sell them.
Marquitos BR88 Posted on June 30, 2020 at 1:48 am
I rlly dont have so much friends to play (serious) the game,so I use this to do dungeons in the vanilla.
The RDF helped me a lot in the later expansions.
EDIT:I used to do this in private servers because of the low population but I bought 6 months of Classic Wow yesterday and I wont use mbx


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Summer Term: English Unit - 6/5/20
Summer Term: English Unit - 6/5/20 Blue review your draft version against the key features check-list
Instructions for 6/5/20
You will need:
* Your draft from yesterday;
* A blue (or any colour really) pen to edit and improve your draft;
* A key features check-list (see attachment - scroll right down);
* A blank piece of paper.
Next steps:
1. Read through your draft version of 'The Dementors Kiss';
2. Check-list: Tick off each of the key features used in your writing;
3. Edit and improve: Add in any missing key features, make any corrections or improvements.
4. Re-write / type your draft on a new piece of paper.
5. Take a photograph or email your improved version to me at Banyan's email address.


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2012 Sacramental Gift Guide
Faith-Inspired Presents for Everyone on Your List: A March 11 issue feature
Springtime and the approaching Easter season bring wonderful opportunities to remember babies' baptismal days, children making their first Communion, young teens receiving the sacrament of confirmation, and RCIA candidates entering the Church.
Here are some gifts that remember the occasion and foster faith growth.
To see the complete gift guide, click here.


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Who Owns Huawei?
Who owns Huawei? American officials have long claimed the controversial telecommunications giant belongs to the Chinese state, while Huawei has long called itself a "private company wholly owned by its employees." Huawei states that its founder, Ren...
ChinaFile Recommends04.28.16
China Wants to Own Small Stake in Web Firms
Wall Street Journal
The Chinese government's control over the Internet could get even tighter, with regulators floating a proposal for the state to take 1% stakes in major Chinese Internet.
An American Open Door?
Asia Society
Over the past decade, China's unprecedented surge of economic dynamism and development has radically altered the global landscape and affected a host of international relationships. One of the most significant trends that will influence how the...


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Stephen King's Lisey's Story Adaptation Adds Clive Owen
For decades, Stephen King's original stories have influenced the pop culture world in interesting ways, spawning countless film and television adaptations. The latest to join the list will be King's 2006 novel Lisey's Story, which will be adapted into an eight-hour limited series from Apple. The series centers around a widow (played by Julianne Moore) discovering dark secrets about her dead husband -- and now we know who will be bringing him to life. According to a new report from Deadline, Clive Owen is attached to play Scott Landon in the upcoming miniseries.
Owen is known for his roles in Children of Men, Closer, and The Knick. He can most recently be seen in the Will Smith-starring movie Gemini Man, which hits theaters this weekend.
You can check out the official synopsis for Lisey's Story below:
"Two years after her husband's death, Lisey Landon decides it's time to go through his office to clear out his papers. Scott Landon was a bestselling novelist and Lisey has been besieged by people wanting to buy any of his unpublished work but she is determined not to let that happen. As she begins the process of cleaning, she is contacted by an unsavory character who claims that if she does not turn over the papers, he will make her suffer the consequences. Finding strength she did not know she had and never used during their marriage, Lisey refuses, and true to his word, 'Zack McCool' begins to stalk her. Lisey begins to remember strange events from her marriage that she had suppressed and finds clues that may help save her life."
J.J. Abrams will produce through Bad Robot Productions. Moore, King, and Ben Stephenson will executive produce. King wrote eight of the series' episodes, years after he began advocating for the story to be adapted in some way.
"Lisey's Story is my favorite of the books and I would love to see that done, especially now that there's a kind of openness on the streaming services on TV and even the cable networks," King shared with Variety in 2017. "There's more freedom to do stuff now and when you do a movie from a book, there's this thing that I call the sitting on a suitcase syndrome."0comments
He added, "That is where you try to pack in all the clothes at once and the suitcase won't close, so you just sit on it until it latches. And sometimes when it comes down on the baggage carousel, it busts open and your dirty laundry is everywhere. So it's tough to take a book that is fully textured and has all the wheels turning and do it in two hours and 10 minutes. But as a TV
Are you excited to see Clive Owen join Lisey's Story? Share your thoughts with us in the comments below!


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Enter or ENTER may refer to:
Enter was an American magazine published from October 1983 to May 1985 by Children's Television Workshop (CTW, later renamed Sesame Workshop). Only 17 issues were printed.
Similar to sibling titles Sesame Street, The Electric Company, and 3-2-1 Contact magazines, the title was aimed at school-age children.
The focus of the magazine was, as declared on the cover, "The world of computers and new technology". Each issue included programs in the BASIC computer language, which readers could type into their own home computer.
Readers were introduced to technological innovations of the day, such as optical disc recording technology, which was new at the time.
Unlike other magazines produced by Children's Television Workshop, Enter did not tie into one of the television series produced by the organization. Perhaps for this reason, the magazine lasted only about a year and a half. Beginning in June 1985, some of its features were folded into 3-2-1 Contact magazine, which printed computer programs as part of an "Enter section" for a short while. This section was later renamed "BASIC training."
Enter is the second release but first full-length album by Russian Circles. It was released on Flameshovel Records on May 16, 2006. The band's use of fade off at the end of each song allows the album to flow continuously. All tracks first appeared on their self-titled EP, with the exception of "Micah" and "Enter."
When you go
You don't know what you get
You might end up all alone
Through the night
The darkness of my eye
You might end up all alone
Stay Tonight
I don't want you to go
I don't even know your soul
In a dream
You come to me in the dark
You are leaning to my head
Cause you were strong
You told what to do
Now I'm leaning on myself
Stay Tonight
I don't want you to go
I don't even know your soul
Through the night
To the morning gold
I am leaving for the stars
Stay Tonight
I don't want you to go
I don't even know your soul
Through the night
To the morning gold
I am leaving for the stars
Enter or ENTER may refer to:
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Trendy liquid nitrogen 'Dragon's Breath' dessert hospitalizes 14-year-old
When The Daily Meal reflects on crazy state fair foods, we usually think of deep-fried bacon cinnamon rolls, pulled pork doughnut sandwiches, and sautéed alligator and fries. The current hot-item treat at Florida's Pensacola Interstate Fair is called Dragon Breath - a confectionary doused in smoking liquid nitrogen. Alas, it's raising eyebrows for potentially fatal health risks.
Today.com reports that Dragon's Breath's vendor describes the treat as a "dessert cereal snack that tastes like Fruit Loops dipped in liquid nitrogen." When patrons eat it, they will "smoke like a dragon."
Video footage posted on Instagram shows that when consumed, a fog-like substance billows from the nostrils and mouth. While that may seem cool, ingestion of liquid nitrogen could lead to severe internal damage.
"The ER doctor had to cut it open, cut away the dead skin and get the infection out," Tina McArthur told WEARTV. "They said had we not come in and got her finger treated she could have possibly lost her thumb."
Liquid nitrogen has a dangerously low temperature between negative 196 and negative 320 degrees Fahrenheit. But Dr. Reed Caldwell told Today.com the substance is destructive to tissue and that it displaces oxygen, so it could very well cause fatal asphyxiation.
For more culinary health hazards, here are the 8 foods and drinks that can put you at risk of getting cancer.
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Located at the mouth of the Adyar River, MRC Nagar is one of the most upscale localities in Chennai. The neighbourhood is named after Mayor Ramanathan Chettiar, a prominent politician and businessman who was a part of the famous Chettiar family. They were once the most influential family in the south and still own the Chettinad Palace, located on the southwest part of the locality. In 1975, the first layout of the neighbourhood was created. By around 1977, a few residents moved here and named the neighbourhood Mayor Ramanathan Chettiar Colony, which was later shortened to MRC Nagar. Land in this locality is now one of the most sought after in the city with numerous popular landmarks including the Leela Palace and Indian Bank Complex located here.If you're looking to stay close to this prime locality on a budget, you needn't worry. There are a number of excellent hotels available around the area that are pocket friendly. If you prefer something comfortable, peaceful, and reasonably priced, you can opt for a guest house near MRC Nagar Chennai. A lot of these guest houses in Chennai near MRC Nagar are designed to function much like a bed-and-breakfast normally would, by offering facilities and services, similar to hotels. In addition to this, you can expect personal attention from the owner, as he/she would normally live in proximity to the hotel. In addition to this, some of the best guest houses in Chennai near MRC Nagar offer home-cooked meals to give guests a chance to taste the local cuisine. If high rates are a problem, you can always opt for budget guest houses in Chennai near MRC Nagar. They might not offer as many amenities, but you will stay comfortably throughout your trip.When you're in the vicinity of MRC Nagar, there are a number of fun things to do to make your trip memorable. You can visit popular attractions like the Chettinad Palace, Tholkappiar Ecological Park, Marina Lighthouse, Marina Beach, Dr. MGR Memorial, Vivekananda House, Santhome Cathedral, Elliot's Beach (Besant Nagar), Aarupadai Veedu Temple, and much more. A few popular restaurants, pubs, and bars in the locality are Fromage, Broken Bridge Cafe, Radio Room, Chao, China XO, Spectra, Jamavar, the Lobby Lounge, Library Blu, Brunch, and Roastery By Coffee Page.
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Going into Week 6 of the 2017 NFL season, here are some fun facts for every game on the schedule.
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- Carolina has alternated between wins and losses over their last four home games, dropping their most recent game at Bank of America Stadium (34-13 loss to New Orleans). They have lost back-to-back home games just once since the start of the 2015 season (Sept. 18-25, 2016).
- The Eagles have earned victories in two of their last three road games. They had lost seven consecutive away games prior to this stretch.
- Carolina is 3-2 on Thursdays since the start of the 2013 season. They have allowed an average of 19.2 points in those matches, the sixth-lowest in the NFL.
- Philadelphia has won two of their last three games played on Thursdays, holding opponents below 20 points in both victories. They had lost their last three games on Thursday prior to this stretch.
- The Panthers totaled just 28 rushing yards in their 27-24 win over Detroit last Sunday, the third-lowest rushing total the team has ever had in a win.
- Dating back to last season, Philadelphia is 6-1 over their last seven games, averaging 26.9 points per game. They were 0-5 while averaging 18.0 points per game in the five games prior.
- In last weekend's win over Detroit, Cam Newton became just the second player in team history to throw for 300+ yards and 2+ touchdowns in back-to-back games. No Panthers player has ever done so in three consecutive games.
- Philadelphia quarterback Carson Wentz has thrown for 1,362 yards this season, the seventh-most passing yards by an Eagles quarterback through the first five games of a season.
- Carolina defensive end Julius Peppers (149.5) needs two sacks to pass Chris Doleman for the fourth-most for in NFL history. However, he has just four sacks in nine regular season games against Philadelphia.
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- This will mark the sixth meeting between the Bears and Ravens. The home team has won each time, most recently a 23-20 overtime win for the Bears on Nov. 17, 2013.
- Baltimore's 26-7 loss in Week 4 snapped a six-game home winning streak. Additionally, their seven points were the fewest in a home game since a 35-6 loss to Seattle on Dec. 12, 2015.
- Chicago is in the midst of a 10-game road losing streak, the team's longest since dropping 12 in a row from Sept. 29, 2002-Sept. 22, 2003.
- Baltimore is averaging just 331 yards per game when playing at home against Chicago, giving up 204.5 yards per game to the Bears when playing at home.
- In Chicago's five games this season, they are giving up an average of 24.8 points per game while only averaging 15.6 points in that same stretch.
- Baltimore's defense is second in the NFL with 12 takeaways, behind only Jacksonville's 15.
- Chicago has only forced three turnovers this season, tied for second fewest in the league. They have also yet to record an interception, one of three teams yet to do so.
- Baltimore had zero turnovers in the Week 5 win over Oakland. They have not had back to back zero turnover games since Nov 18-25, 2012.
- Baltimore cornerback Jimmy Smith had a 47-yard fumble return for a touchdown last week. It was the first fumble return for touchdown in his career and only the third fumble return for touchdown since the start of the 2012 season for the Ravens. The Ravens had three fumble return touchdowns in 2011.
- Chicago Bears punter Pat O'Donnell threw a 38-yard touchdown pass in Week 5. It was the first touchdown pass in his career.
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- The Packers have won five of their last eight meetings with Minnesota the including two losses and one draw. They have limited the Vikings to 21-or-fewer points five times in that stretch.
- Minnesota's 14-7 loss to Detroit on Oct. 1st snapped a three-game home winning streak. The team had scored 29+ in all three contests, their longest streak since Nov. 4-Dec. 2, 2007.
- Green Bay's 34-20 loss at Atlanta on Sept. 17th snapped a three-game road winning streak. The Packers, who had two giveaways and no takeaways in the defeat, forced six turnovers and had no giveaways during the streak.
- Minnesota has allowed one rushing touchdown on the season, good for second in the league behind only the Denver Broncos who have allowed zero.
- Green Bay enters as winners of 10 of their last 11 regular season games, averaging 29.0 points per game and turning the ball over just five times in that span. They had six turnovers in the three games prior.
- Minnesota defensive end Everson Griffen recorded a sack in their win over Chicago last week, his fifth consecutive game with a sack. It ties his personal best for games with a sack (Oct 2, 2014 - Nov 2, 2014).
- Green Bay receiver Davante Adams scored two touchdowns against the Cowboys in Week 5. It was the fourth time the receiver hauled in two touchdowns, most recently in Week 16 of the 2016 season against the Lions on Jan. 1, 2017.
- Vikings wide receiver Stefon Diggs has caught 13 passes for 211 yards and two touchdowns in his last two games against Green Bay. He had seven receptions for 74 yards and no touchdowns in his first two against the Packers.
- Green Bay rookie running back Aaron Jones rushed for 125 yards, the most by a Packers rookie since Eddie Lacy rushed for 141 yards on Dec. 15, 2013.
- Minnesota safety Harrison Smith has 14 interceptions since entering the league in 2012, four of which he has returned for touchdowns. Only four players have more interception return touchdowns in that time.
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- Atlanta and Miami have split their last four meetings, with each side earning two wins. This will be just the second meeting in Atlanta since the start of the 1999 regular season.
- The Falcons' Week 4 loss to the Bills put an end to the team's five-game home winning streak (inc. playoffs), their longest since 2013. It also was the first time they failed to score at least 20 points in a home game since Jan. 1, 2016 (franchise-long 11-game streak).
- Miami's 20-6 loss to the Jets on Sept. 24thsnapped a three-game road winning streak in the regular season. The six points they managed is tied for their fewest in a road game since the start of the 2014 season.
- Atlanta held Buffalo to just 164 passing yards in a Week 4 loss, the first time since Nov. 29, 2015, that the Falcons held their opponent to less than 175 passing yards but still lost the game.
- Miami has yet to record a rushing touchdown in 2017, the only team left without one. They had four through the first five weeks and 14 total in 2016.
- Atlanta running back Devonta Freeman is tied for the NFL lead in rushing touchdowns (five) with Jacksonville's Leonard Fournette. His career high is 11, a mark he reached in both 2015 and 2016.
- Miami is averaging just 156.5 yards passing per game, last in the NFL. Only three other teams are averaging less than 182.0 passing yards per game.
- Atlanta receiver Julio Jones has yet to score a receiving touchdown in the first four games of the season. It is his second-longest stretch to open a season since his rookie year (five games, Sept. 11, 2011 - Oct. 9, 2011)
- Miami's defense is allowing just 75.5 rushing yards per game, good for fourth in the NFL, while Atlanta is averaging 125.8 yards rushing on offense, good for eighth the league.
- Atlanta has scored on 46.3% of its offensive drives this season, the sixth-best percentage in the league. Last season, they scored on 52.6% of their drives, the best in the NFL.
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- New England has won 10 of the 12 games against the Jets, averaging 28.5 points per game against their division rivals. Both losses came at MetLife Stadium.
- The Jets have won their last three home games, tied for their longest home winning streak since the start of the 2012 regular season.
- New England has not lost a road game since the start of the 2016 regular season. Their 10-straight road wins are tied for the longest streak in team history (last done Sept. 9, 2007-Oct. 5, 2008).
- New York hasn't had a four-game winning streak since a five-game winning streak from Nov. 29-Dec. 27, 2015.
- New England leads the NFL in passing yardage through five weeks with 1,602 yards, averaging 320.4 yards per game. No other team is averaging more than 290 yards per game.
- New York rookie running back Elijah McGuire is averaging 5.2 yards per carry this season, the fifth best among rookie running backs with at least six carries.
- New England receiver Chris Hogan caught his fifth touchdown pass of the season in Week 5's win over Tampa Bay, setting a new career high for touchdown receptions in a season.
- New York quarterback Josh McCown is completing 71.4% of his passes this season, good for second in the NFL among qualified players. His highest completion percentage for a season is 66.5% in 2013 for the Chicago Bears.
- New England quarterback Tom Brady threw for 303 yards last week, the 80thtime he has gone over the 300-yard passing mark in the regular season, the third most in NFL history.
- New York tight endAustin Seferian-Jenkins caught six passes in Week 5's win over Cleveland. This set a new career high for the fourth-year tight end.
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- New Orleans has alternated between wins and losses over their last six home games, losing 36-20 to the Patriots in their most recent game in the Mercedes-Benz Superdome. They are looking to go three straight homes games without a turnover for the first time since Dec. 8, 2013-Sep. 21, 2014.
- The Lions are looking for their third three-game road winning streak in the same season since the start of the 2012 regular season. Detroit is looking to allow 10-or-fewer points in three straight road games for the first time since doing so from Dec. 4, 1977-Sep. 9, 1978.
- New Orleans has won their last five home games coming off of a bye week. They are averaging 39.4 points per game in those five contests, while only surrendering 25.
- Detroit is forcing a turnover from their opponents on 18.6% of their drives this season, good for the third-best turnover rate in the NFL.
- New Orleans shutout Miami 20-0 in Week 4, their most recent game. They haven't pitched two shutouts in a single season since 1991.
- Detroit quarterback Matthew Stafford has thrown for 1,507 yards in only five career games against the Saints, the most he has against any team outside the NFC North
- New Orleans quarterback Drew Brees hasn't thrown an interception in his first four games, the third-longest such streak in his career. He last went six straight games without an interception from Dec. 13, 2015 - Sep. 18, 2016.
- In Week 4, New Orleans rookie running back Alvin Kamara recorded 10 receptions for 71 yards. It was the most receptions by a Saints rookie running back since Pierre Thomas secured 12 receptions for 121 yards on Dec. 30, 2007.
- Lions tight end Darren Fells recorded two touchdown receptions last week, a career high for single game. Fells only had four touchdown receptions in his career before that last game.
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- Houston has won five of their last six games against Cleveland, holding the Browns to 12-or-fewer points four times.
- Houston enters Week 6 averaging 32.6 points per game at home. They are 9-1 in their last 10 home games when scoring more than 32 points. Their Week 5 loss to Kansas City (42-34) is the only blemish in their last such 10 games.
- Cleveland enters this week in the midst of a 15-game road losing streak, allowing 28.3 points per game in that time. Additionally, they have scored more than 24 points just two times during the streak.
- Houston is currently fourth in the NFL in scoring offense with 28.8 points per game. They finished the 2016 season fourth from the bottom with only 17.4 points per game.
- Cleveland first overall pick Myles Garrett made his NFL debut last week and recorded two sacks. He was just the fourth Browns player to record two sacks in his debut and first since Charles Buchanan on Oct. 16, 1988.
- Last week, Houston quarterback Deshaun Watson joined Robert Griffin III in 2012 as the only rookie quarterbacks to throw 4+ touchdowns in back-to-back games. Only three quarterbacks in league history have ever done so in three-or-more games, most recently Drew Brees from Dec. 18, 2011-Jan. 1, 2012.
- Cleveland tight end David Njoku is tied for the league lead with touchdown receptions by a tight end with three. His three receiving touchdowns are also the most for any rookie this season.
- Houston wide receiver Will Fuller has two touchdown receptions in back-to-back games, the first time he has managed to do so in his career. He is also the first Texans receiver to do so since Andre Johnson (Nov 3, 2013 - Nov 10, 2013).
- Cleveland quarterback Kevin Hogan came on in relief of DeShone Kizer and finished with his first two touchdown game of his career. Hogan finished Week 5 with 194 yards and two touchdowns, both career highs for the second-year pro.
- Houston wide receiver DeAndre Hopkins set a personal best with the three receiving touchdowns in the Week 5 loss to the Chiefs.
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- San Francisco has won their last four games against Washington, dating back to Week 17 of the 2008 season. The Redskins had won three of their four games prior to this streak.
- Washington is 5-5 at home since the start of last season. They are 5-1 with scoring 20+ points in this time, and 0-4 when they do not.
- San Francisco has won just two road games since the start of the 2015 season, the second-fewest of any team over that time.
- Washington is 2-3 over their last five games, dating back to last season, despite holding opponents to 20-or-fewer points three times.
- San Francisco is coming off of back-to-back overtime losses, the first time in team history they have won to overtime in consecutive weeks. They have lost six straight games, averaging 18.7 points per game in that time.
- The Redskins are averaging 4.5 yards per carry, tied for the sixth highest in the league. However, they have just two rushing touchdowns, tied for the sixth fewest in the league.
- San Francisco has committed 49 penalties for 385 yards in 2017, both of which are the most by any NFL team.
- Washington quarterback Kirk Cousins has completed 68.1% of his passes since becoming the starting quarterback prior to the 2015 season, the second-best completion percentage of any quarterback with at least 1,000 pass attempts in that time.
- San Francisco running back Carlos Hyde was limited to just 11 yards on eight carries in their loss to Indianapolis in Week 5, the third-fewest yards he has ever had in a game.
- Running back Chris Thompson is the first Washington player with 2+ rushing and receiving touchdowns in back-to-back seasons since Mike Thomas did so in four straight years (1975-1978).
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The Rams and Jaguars have met just four times before, with the home team winning each time. Both teams have scored 20+ points in three of the four meetings.
Jacksonville has won two of their last three home games, scoring at least 38 points in both wins. They had won two of their previous 10 games at EverBank Field, scoring more than 23 points just once.
Los Angeles has won back-to-back road games, scoring 35+ in both contests. They have not won three straight road games since Nov. 25-Dec. 23, 2012, and have never scored 35+ in three straight road games.
The Jaguars forced five turnovers in their 30-9 victory over Pittsburgh in Week 5, their most in a game since forcing seven in a 41-14 win over Tampa Bay on Dec. 11, 2011.
The Rams had five turnovers in their 16-10 defeat to the Seahawks last week, tied for their most in a game since the start of the 2008 season. They turned the ball five times in their first four games in 2017.
Jacksonville running back Leonard Fournette had a 90-yard touchdown run in Week 5, the longest run in franchise history. Fournette's 181 rush yards in Week 5 are tied for fifth most in a single game in franchise history.
Los Angeles running back Todd Gurley averaged just 3.1 yards per carry in their loss to Seattle in Week 5. He had averaged 4.8 yards per carry in the three weeks prior.
Jaguars defensive end Calais Campbell has six sacks in five games with the team this year. Only two Jaguars had more than 6.0 sacks in 2016.
Rams wide receiver Sammy Watkins has two touchdown catches in five games this season, as many as he had in eight games with Buffalo last season.
Jacksonville tight end Marcedes Lewis has three receiving touchdowns in 2017, tied for the most of any tight end. He had three receiving touchdowns between 2014 and 2016.
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- Arizona has won the last two games against Tampa Bay, outscoring them 53-17 in the process. They had won just two of their last eight games against the Buccaneers prior to this stretch.
- Arizona's 18-15 overtime win against San Francisco in Week 4 snapped a two-game home losing streak, the first time the team had lost back-to-back home games since the start of the 2013 season.
- Tampa Bay has lost their last three road games, allowing at least 26 points in all three contests. They have not lost four straight away games since Dec. 1, 2013-Sept. 8, 2014.
- Arizona is averaging 2.6 yards per rush this season as a team, the lowest in the league. Last season, they averaged 4.3 yards per attempt, tied for the 12th best in the league.
- Tampa Bay has just four sacks this season, the fewest in the league. Only three other teams have less than 10 sacks this year, and no other team has fewer than seven sacks.
- Arizona is averaging 1.25 points per drive this season, the second fewest in the league. Last season, they averaged 2.03 per drive, 14thin the NFL
- Tampa Bay receiver Desean Jackson is averaging 17.8 yards per reception this season, the fifth highest in the league. Jackson has not averaged less than 17 yards per reception since 2013, his last year in Philadelphia (16.2).
- Arizona wide receiver JJ Nelson is averaging 55.4 receiving yards per game this season, a career-high. He has never averaged more than 38 yards per game in his career.
- Tampa Bay quarterback Jameis Winston has been sacked just seven times this season, tied for the eighth-fewest in the league among quarterbacks with at least two starts. Last season he was sacked 35 times, tied for the 12thmost in the league.
- Arizona running back Andre Ellington has caught 28 passes for 257 receiving yards this year, more than he had in the previous two seasons combined.
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- The Steelers have won five of their last six games against Kansas City, including an 18-16 win in the Divisional Round of last year's playoffs.
- Kansas City has won their last three regular season home games, tallying 400+ yards of offense in all three wins. This ties a franchise record for yards gained in home games, last done Sept 26-Oct 31, 2010.
- Pittsburgh has won six of their last seven road games, allowing an average of 14.9 points per game. They had won six of their previous 13 away games, allowing an average of 22.2 points per game.
- Kansas City has scored the most points this season with 164 and they are one of two teams with over 2000 total yards of offense this year with 2071 (New England, 2097).
- Pittsburgh wide receiver Antonio Brown is leading the NFL with 40 receptions and 545 receiving yards, but only has one receiving touchdown through five weeks. It is the first time he has had less than two touchdowns in the first five games since 2012.
- Kansas City's Tyreek Hill became just the second player this season to return a punt for a touchdown, Jamal Agnew for Detroit was the first. Hill has a 12.5-yard punt return average, the second-best in the league.
- Pittsburgh running back Le'Veon Bell leads the league with 129 touches, only five other players have more than 100 touches this season.
- Chiefs tight end Travis Kelce has 353 receiving yards, the second most in the league among tight ends. His 12.2 yards per reception is the third most among tight ends with at least 25 targets.
- Pittsburgh quarterback Ben Roethlisberger had five interceptions last game, a career high. He now has three games with at least four interceptions, tied for the seventh-most such games among active quarterbacks.
- Kansas City quarterback Alex Smith has 11 touchdowns this season, the most of any quarterback with no interceptions this season.
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- Oakland had their six-game home winning streak snapped last week, putting up just 245 yards of offense in the defeat. It was their fewest yards in a home game since putting up 222 yards of offense in 41-17 loss to Denver on Nov. 9, 2014.
- Los Angeles has lost their last nine road games against current AFC West opponents, the second-longest such streak in team history. They lost 10 straight from Oct. 23, 1983-Oct. 19, 1986.
- Oakland is looking to avoid their first four-game losing streak since dropping 16 straight from Nov. 24, 2013-Nov. 16, 2014.
- Los Angeles snapped a nine-game losing streak with their 27-22 win over New York in Week 5, which was tied for the third longest in team history.
- Oakland is one of three teams that has yet to record an interception this season, along with the Chicago Bears and Miami Dolphins. They had 16 last season, tied for the ninth most in the NFL.
- Los Angeles quarterback Philip Rivers has 1,365 passing yards through five games, the seventh time he has accumulated that many passing yards through the team's first five games of a season. Only New Orleans' Drew Brees has done so more since the start of the 2004 season (eight).
- Raiders wide receiver Michael Crabtree has caught four touchdowns in six games against the Chargers, tied for his fifth-most against any NFL team.
- Los Angeles defensive end Melvin Ingram has 26.0 sacks since the start of 2015, including his 7.5 this year– the second most in the league. Only three players have more sacks in that time.
- Oakland defensive end Mario Edwards Jr. has 3.0 sacks in five games this season. He had 2.0 in his first 16 games in the league
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The Broncos have played the Giants four times since 2000 and won three of the four games. Denver has outscored the Giants 121-73 over those four games.
Denver has won their last four home games and they have held those teams to under 300 yards of total offense, the current longest active streak in the league.
New York has won just one of their last six road games. The Giants have scored more than 20 points in just two of those games.
Denver is 13-4 in games following their bye weeks since the 2000 season, tied for the second-best record in the league.
New York is averaging just 1.4 points per drive this season, the fifth lowest in the NFL.
Denver has allowed just 60 first downs this season, the fewest in the league. Washington (69) is the only other team to have allowed less than 70 first downs this season.
Giants rookie running back Wayne Gallman has 132 yards from scrimmage, seventh most on the team. However, since he has played just two games this season, he is averaging 66 yards per game, the second-best rate on the team.
Denver linebacker Von Miller has 4.0 sacks through the first four games this season, tied for the second-most he has had in the first quarter of a season in his career. He had 5.5 sacks through the first four games last season.
New York safety Landon Collins has now gone 11 games without an interception, the second-longest drought in his career. He went 16 games between his first and second interception.
Broncos wide receiver Demaryius Thomas has gone 10 regular season games without catching a touchdown, the longest dry spell in his career.
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- The Colts have beaten the Titans in 11 consecutive regular season games. In their 20 games previous, the Colts had won 14 times.
- Tennessee has won five of their last six home games by an average score of 28.2 to 21.2. Over their previous six home games the Titans went 2-4 and were beaten by a score of 29.2 to 21.3 on average.
- Indianapolis has lost their last three road games after winning their previous four away from home. Over their three-game skid, they allowed 30-or-more points in each of the games. While in their four-game winning streak prior, they did not allow any opponents to score more than 26 points.
- Tennessee has allowed 12 passing touchdowns this season, tied with New England for the most in the league.
- Indianapolis is allowing an average of 31.8 points per game this season, the most in the league. No other team is allowing more than 29 points per game.
- Titans running back DeMarco Murray is averaging 4.9 yards per rush this season, the fourth best among running backs with at least 200 yards this season.
- Indianapolis wide receiver T.Y. Hilton has 466 receiving yards this year, the third most in the league. Hilton is one of four receivers with at least 400 receiving yards this season.
- Tennessee defensive lineman Jurrell Casey has a sack in each of his last two games, tied for the second-longest streak of his career. Casey had a sack in three straight games from Oct. 20 – Nov. 10, 2013, in which he recorded 4.0 total sacks.
- Colts safety Malik Hooker has three interceptions already this season, tied for second most in the league.
- Tennessee quarterback Marcus Mariota has thrown six touchdowns against the Colts, the second most he has thrown against any team in his career.