text:
Taylor & Wright Ambleside Slim Fit Trousers
We're sorry but this item is not in stock.
- Product Info
A versatile addition to your work and formalwear wardrobe, the Ambleside trousers from Taylor & Wright come in a smart grey textured fabric. Carrying a flattering slim fit through the leg, these trousers are finished with slanted front pockets, belt looks and welt back pockets.Additional Details100% Polyester.CareMachine Washable. Dry Cleanable.Product IDS2763295_C228Share On
- Reviews
- Delivery & Returns
Standard Home Delivery: £3.95 or FREE on orders over £50
Your order will arrive within 5 working days. Deliveries are made between Monday-Friday.
Next Day Home Delivery: £4.95
Order before 4pm Monday-Friday for home delivery the next working day. Any orders placed after 4pm on a Friday will be delivered on Tuesday.
Click & Collect:FREE
Your order will arrive in store within 5 working days.
We'll be happy to exchange or refund within 14 days of purchase if you bought the items in store, or within 14 days of you receiving the items if you ordered them online. Items must be returned with the original receipt, unworn and in the condition they were purchased, including all packaging.
In store: FREE
By post: A delivery charge is applicable.Delivery Information Returns Information


text:
| 13.6°C Belfast
Everything comes to those who wait. And few teams have had to exercise the level of patience required from St Patrick's College, Cavan in their pursuit of a major sporting goal.
But yesterday at the Athletics Grounds, Armagh, a 43-year famine ended in the most spectacular fashion when the Breffni county seat of learning thundered to a stunning MacRory Cup success.
All the heartbreak, frustration and disappointment experienced through the decades were forgotten as a well-drilled, composed and utterly committed side wrote their own special chapter in the history of one of Ulster's most enduring competitions.
Thomas Galligan's masterly contribution at midfield, a deadly two-goal salvo from diminutive corner-forward Thomas Edward Donohoe, a brace of superb saves by goalkeeper Fergal O'Rourke and an inspired performance from centre-half-back Cian McManus offer a snapshot of the in-depth quality of a team that were clearly on a mission.
No wonder joint-manager Finbarr O'Reilly was ecstatic.
"We have had bleak times in the past but an awful lot of hard work went into this MacRory Cup campaign and it has paid off," beamed O'Reilly.
"These boys won't hear of the word defeat and now we will focus on the Hogan Cup. This is a big breakthrough for us and we hope it marks the start of better things."
The Academy flattered to deceive at midfield, the early influence of Colin Campbell and Brian Kennedy giving way to the subsequent total authority of the immense Galligan.
Academy manager Ciaran Gourley, although palpably distraught, was gracious in defeat.
"We missed a couple of goal opportunities and had they been taken it might have been different. The Cavan side kept chipping away at us and then when we found that we were chasing the game, we left ourselves open at the back and got punished. Having said that, they were the better team and deserved their win," said Gourley.
The Breffni boys led by 0-6 to 0-4 at half-time despite having lost their cultured full-forward Ben Conaty, who was replaced by Ryan O'Neill.
But if the winners were naïve in terms of protecting their possession and carrying the ball into tackles before the break, these flaws were quickly erased from their play in the second half.
And with Donohue, the impressive Darragh Kennedy and Pauric Smith thriving on a bountiful supply of the ball, the Cavan side swept into top gear.
A three-point haul spanning the 39th and 46th minutes following goalkeeper O'Rourke's miraculous save from Daniel Kerr triggered their level of dominance.
The loss of skipper Fintan McClure to a black card in the 41st minute impacted the Academy's morale and although Ciaran Higgins, Conall Lyons and Kerr tried hard, they were unable to help wrest back the initiative.
The Cavan team's authority was cemented when 16-year-old Donohue stole in for his first goal in the 50th minute and then garnished this with a second five minutes later before Galligan appropriately had the final say when he steered over a long-range point.
In the day's curtain-raiser, the all-Monaghan MacLarnon Cup decider ended in an emphatic 4-8 to 0-8 win for Our Lady's, Castleblayney over Patrician, Carrickmacross.
A superb solo show by Barry McGinn underlined Our Lady's decisive victory as the lively Doohamlet player scored 1-6 and created several other scores.
By half time McGinn had already left his imprint on the game by landing 1-2 as his side took a 1-5 to 0-3 lead at that stage.
With Jamie Walsh and James Wilson also prominent in their attack, the Castleblayney side thrived on valuable possession won in midfield by John Leonard and Conor Marray.
Walsh and Wilson emphasised their respective roles when they each grabbed a goal as their side streaked into a 3-5 to 0-6 lead.
There was simply no way back for the Carrickmacross school and when Michael Branagan netted a fourth Castleblayney goal, he merely underlined the gulf that existed between the sides.
St Patrick's Academy, Dungannon: C Donaghy; C Barker, C Higgins, C Lyons; L Rafferty, S Corr, M McKernan; C Campbell, B Kennedy; C O'Hagan 0-3 (all frees), D Kerr 0-2, C Kilpatrick; R Coleman 0-1 (f), F McClure 0-1 (f), M Donnelly 0-1. Subs: P Molloy for McClure (41), L Mallon for Kilpatrick (48), N Muldoon for Corr (58). Black card: McClure (41).
St Patrick's College, Cavan: F O'Rourke; D Lunney, D Monaghan, L Fortune 0-1; D Kennedy 0-2, C McManus, J J McGovern; T Galligan 0-2, B Argue 0-1; P Smith 0-1, P Leddy 0-1, M McKenna 0-1; C Smith, B Conaty, T E Donohoe 2-3 (3f). Subs: R O'Neill for Conaty (14), D Brady for Leddy (39), P O'Reilly for Lunney (46), S Fortune for L Fortune (51), J Veale for McKernan (57). Yellow card: Argue (46).
Referee: Padraig Hughes (Armagh)
Belfast Telegraph

subset: commoncrawl


text:
"You're planning to desire to just simply take down your garments and touch each other. But should you choose touch one another, you're going to get Chlamydia… and die. "
There's nothing like just a little Mean Girls and an extremely dramatic teacher that is sex-ed frighten you far from intercourse. But while your time that is first may frightening, you don't need certainly to worry—because we're here to help you through it! You've currently learned all about the potential risks (perchance you've seen one way too many STI images) and advantages connected with intercourse, but how's a lady to understand exactly what to realistically expect? We talked with a few sexperts that will help you better prepare—physically and mentally—for whenever you're prepared to make the step that is next.
Does it harm?
Whenever contemplating intercourse, worrying about discomfort is a concern that is perfectly normal have! Continue reading


text:
The following is a company-submitted press release and does not necessarily represent the views or opinions of Spaces4Learning.
AUGUSTA, ME – Governor Paul LePage joined leaders of the University of Maine and Maine Community College Systems on June 8th at a signing ceremony in Augusta for a comprehensive and far-reaching transfer agreement that is designed to reduce college costs for Maine students and speed their time to degree completion.
The agreement, signed by University of Maine System Chancellor James Page and Maine Community College System President Derek Langhauser, will make it possible for students enrolled in any one of Maine's 14 community colleges and public universities to complete up to 35 credits of their general education requirements and transfer that block of credits, for full credit, to any of the other institutions within the two systems.
"It is not where you start, but how far you go that matters," says Chancellor Page. "With this agreement we are ensuring the same learning outcomes, same expectations and same credit for our students across all 14 of Maine's public colleges and universities so Maine learners can more easily and affordably progress along the path to advancement."
Until now, the transfer process between the two systems has been guided by over 150 transfer agreements between specific programs of study. These articulation agreements largely determine which credits will transfer and whether they will count towards the requirements of specific baccalaureate degree programs.
"Every year, over 750 of our students transfer to the University of Maine System," notes President Langhauser. "This agreement and other joint transfer initiatives are designed to serve the best interests of those students and to make sure they are able to get the education they need as quickly and affordably as possible. Thanks to the hard work of faculty and staff across our institutions, this agreement will help ensure that our students are prepared to be successful at each step in their educational journey."
"Improving cooperation among Maine's public universities and colleges makes sense for our students, the taxpayers who support these public institutions, and an expanding Maine economy that needs access to skilled and talented workers to continue to grow," says Maine Governor Paul LePage. "The general education transfer agreement between the university and community college systems is a good step forward in improving quality, affordability and access for Maine students."
The new block transfer agreement builds on two other UMS/MCCS transfer initiatives designed to help ensure that students are able to earn all of the college credits and credentials to which they are entitled. The first of these is a practice known as reverse transfer that enables MCCS students who transfer to the UMS before earning a community college credential to transfer credits earned at the UMS back to the community college to complete their MCCS degree or certificate.
Another new initiative addresses how the 14 institutions award credit for prior learning and work experience. Faculty committees at both the UMS and MCCS are currently working to establish common scores and standards for portfolio and credential review so that students can carry forward prior learning credits awarded by any of the 14 institutions as they transfer between the two systems.
Both Chancellor Page and President Langhauser note that these transfer initiatives have required significant effort on the part of faculty and administrators at both the UMS and MCCS as they work to align curriculum, develop common assessments, and implement new policies and practices at all 14 institutions. That collaboration will continue as the groups implement the new block transfer agreement (which is intended to be fully operational within both the UMS and MCCS by fall 2016), redesign courses, develop common assessment approaches, monitor progress, and create additional educational pathways in technical fields of study.
Together, the University of Maine System and the Maine Community College System enroll nearly 44,000 undergraduate students each year at fourteen institutions across the state. In one recent three year-period, 42 percent of MCCS graduates pursued further education. Forty percent of these graduates (1,115) did so within the University of Maine System.
Read the Memorandum of Understanding (PDF).
View More Webcasts
View More White Papers


text:
London, England — 17 July 2012 – Mining giant Rio Tinto has had a strong second quarter of 2012 across most of its portfolio, with record first half iron ore production, and copper, bauxite, alumina, coking coal and titanium dioxide production all higher than in the second quarter of 2011.
"Global economic conditions and sentiment dropped markedly in the second quarter," says chief executive Tom Albanese. We are keeping a close eye on the pace of the US recovery, the continuing Euro-zone crisis and the impact of efforts to stimulate the Chinese economy on the markets that we serve. "Our investment programme remains resilient to market volatility, however, as our tier one projects are robust under any probable macroeconomic scenario."
He underlined the following highlights:
- First half iron ore production of 120Mt (94Mt attributable) and shipments of 115Mt were both four per cent higher than the first half of 2011. Global iron ore production for the quarter totalled 62Mt (49Mt attributable), in line with the second quarter of 2011.
- During the quarter, Rio Tinto announced further investments to advance the expansion of its industry-leading Pilbara iron ore business to 353Mtpa, and to progress further the Simandou iron ore project in Guinea.
- Mined copper production was five per cent higher than the second quarter of 2011, primarily driven by processing efficiencies and higher copper grades at Escondida.
- Bauxite and alumina production were eight per cent and five per cent higher than the second quarter of 2011. Aluminium was 12% lower than the second quarter of 2011.
- Hard coking coal production was 13% higher than the second quarter of 2011, and thermal coal production was consistent. In June 2012, Rio Tinto announced the first shipment of premium hard coking coal from its Benga Mine in Mozambique.
- Titanium dioxide feedstock production increased five per cent from the corresponding period in 2011.
Source: Rio Tinto. For more information, click here.


text:
A massive database of current U.S. Immigration and Customs Enforcement (ICE) employees scraped from public LinkedIn profiles has been removed from the tech platforms hosting the data. The project was undertaken by Sam Lavigne, self-described artist, programmer and researcher in response to recent revelations around ICE's detention practices at the southern U.S. border.
Lavigne posted the database to GitHub on Tuesday and by Wednesday the repository had been removed. The database included the name, profile photo, title and city area of every ICE employee who listed the agency as their employer on the professional networking site. A more in-depth version of the data pulled all public LinkedIn data from the pool of users, including previous employment, education history and any other information those users opted to make public. The total database lists this information for 1,595 ICE employees, from the company's CTO on down to low-level workers.
The project accompanied a Medium post about the project's aims that has since been removed by the platform:
While I don't have a precise idea of what should be done with this data set, I leave it here with the hope that researchers, journalists and activists will find it useful…
I find it helpful to remember that as much as internet companies use data to spy on and exploit their users, we can at times reverse the story, and leverage those very same online platforms as a means to investigate or even undermine entrenched power structures. It's a strange side effect of our reliance on private companies and semi-public platforms to mediate nearly all aspects of our lives.
The data set appears to have violated GitHub and Medium guidelines against doxing. Medium's anti-harassment policy specifically forbids doxing and defines it broadly, preventing "the aggregation of publicly available information to target, shame, blackmail, harass, intimidate, threaten, or endanger."
Because it doesn't include personal identifying information like home addresses, phone numbers or other non-public details, Lavigne's project isn't really doxing in the normal sense of the word, though that hasn't made it less controversial.
GitHub's own policy leading to the data's removal is less clear, though the company told The Verge the repository was removed due to "doxxing and harassment." The platform's terms of service forbid uses of GitHub that "violate the privacy of any third party, such as by posting another person's personal information without consent." This leaves some room for interpretation, and it is not clear that data from a public-facing social media profile is "personal" under this definition. GitHub allows researchers to scrape data from external sites in order to aggregate it "only if any publications resulting from that research are open access."
While Lavigne's aggregation efforts were deemed off-limits by some tech platforms, they do raise compelling questions. What kinds of public data, in aggregate, run afoul of anti-harassment rules? Why can this kind of data be scraped for the purposes of targeted advertising or surveillance by law enforcement but not be collected in a user-facing way? The ICE database raised these questions and plenty more, but for some tech companies the question of hosting the data proved too provocative from the start.
Source: TechCrunch
Dating app Happn, whose "missed connections" type of dating experience connects people who have crossed paths in real life, is fighting back at Tinder. Seemingly inspired by Happn's location-based features, Tinder recently began piloting something called Tinder Places – a feature that tracks your location to match you with those people who visit your same haunts – like a favorite bar, bookshop, gym, restaurant, and more.
Of course Tinder's move into location-based dating should worry Happn, which had built its entire dating app around the idea of matching up people who could have met in real life, but just missed doing so.
Now, Happn is challenging Tinder Places with a new feature of its own. It's debuting an interactive map where users can discover those people they've crossed paths with over the past seven days.
Happn founder, French entrepreneur Didier Rappaport, dismisses the Tinder threat.
"We don't see it as a threat at all but as a good thing," he tells TechCrunch. "Find the people you've crossed paths with has always been in Happn's DNA since the beginning….We are very flattered that Tinder wants to include the same feature in its product. However, we will never use the swipe in our product," he says.
Rappaport believes swiping is wrong because it makes you think of the other person as a product, and that's not Happn's philosophy.
"We want to [give our users a chance] to interact or not with a person, to take their time to decide, to be able to move back in their timeline if suddenly they change their mind and want to have a second chance," he notes.
To use Happn's map, you'll tap on a specific location you've visited, and are then presented with potential matches who have been there too, or within 250 meters of that spot. The map will use the same geolocation data that Happn already uses to create its timeline, but just displays it in another form.
For those who aren't comfortable sharing their location all the time with a dating app (um, everyone?), Happn also offers an "invisibility" mode that lets people hide their location during particular parts of the day – for example, while they're at work.
While Happn's new feature is a nice upgrade for regular users, Tinder's location-based features – we're sorry to report – are more elegantly designed.
Today, Happn's invisibility mode has to be turned on when you want to use it, or you have to pay for a subscription to schedule to come on automatically at certain times. That means it requires more effort to use on a day-to-day basis.
Meanwhile, Tinder Places lets you block a regular place you visit – like, say, the gym – from ever being recorded as a place you want to show up for matches. It also automatically removes places that would be inappropriate, including your home and work addresses, and alerts you when it's adding a new one – so you can quickly take action to remove it, if you choose. Tinder Places is also free. (It's just not rolled out worldwide at this time).
Happn, however, does offer a way to hide your profile information and other details from select users, and never shows your current location in real time, also like Tinder.
Happn, which launched back in 2014, now claims nearly 50 million users worldwide, across 50 major cities and 40 countries. It claims to have 6.5 million monthly users – but that's much smaller, compared with Tinder's estimated 50 million actives.
And with Tinder parent Match Group snatching up Hinge, suing Bumble, and effectively copying the idea of using "missed connections," one has to wonder how much life rival dating apps, especially those of Happn's size, have left.
The app is a free download on the App Store, Play Store and Windows Store.
Source: TechCrunch
Microsoft's newly revealed USB-C port patent could lead to even thinner USB-C-enabled Surface devices. The Surface Pro and rumored Surface Tablet and Surface Phone would likely benefit from this thinner and stronger port design.
The post Microsoft's new USB-C port could enable even slimmer Surface products appeared first on Digital Trends.
Source: Digital trends
From next month two Google StreetView cars will be driving around London's streets fitted with sensors that take air quality readings every 30 meters to map and monitor air quality in the UK capital.
There will also be 100 fixed sensors fitted to lampposts and buildings in pollution blackspots and sensitive locations in the city — creating a new air quality monitoring network that Sadiq Khan, London's mayor, is billing as "the most sophisticated in the world".
The goal with the year-long project is to generate hyperlocal data to help feed policy responses. Khan has made tackling air pollution one of his priorities.
It's not the first time StreetView cars have been used as a vehicle for pollution monitoring. Three years ago sensors made by San Francisco startup Aclima were fitted to the cars to map air quality in the Bay Area.
The London project is using sensors made by UK company Air Monitors.
The air quality monitoring project is a partnership between the Greater London Authority and C40 Cities network — a coalition of major cities around the world which is focused on tackling climate change and increasing health and well-being.
The project is being led by the charity Environmental Defense Fund Europe, in partnership with Air Monitors, Google Earth Outreach, Cambridge Environmental Research Consultants, University of Cambridge, National Physical Laboratory, and the Environmental Defense Fund team in the United States.
King's College London will also be undertaking a linked study focused on schools.
Results will be shared with members of the C40 Cities network — with the ambition of developing policy responses that help improve air quality for hundreds of millions of city dwellers around the world.
Source: TechCrunch
CES may be the largest consumer electronics show in the U.S., but IFA owns bragging rights as the largest CE show outside of the states. The show runs Aug. 31 to Sept. 5, and because of its timing (just in time for buyers to place Christmas orders), IFA frequently plays host to several first-time product unveilings, […]
The post IFA 2018 Complete Coverage appeared first on Digital Trends.
Source: Digital trends
During the Computer Vision and Pattern Recognition conference, Nvidia CEO Jensen Huang randomly chose 20 from more than 500 attendees to receive a limited-edition "CEO Edition" version of its $3,000 Titan X graphics card.
The post Nvidia hands out $3,000 Titan V graphics cards for free to A.I. researchers appeared first on Digital Trends.
Source: Digital trends
Intel said Brian Krzanich stepped down as the company's CEO and is no longer on the board of directors. The reason for the immediate departure is due to a "consensual" relationship with an employee, violating company policy.
The post Intel CEO Brian Krzanich forced to resign after mixing business with pleasure appeared first on Digital Trends.
Source: Digital trends
Nomadic, a Japanese brand sold by JetPens in the US, makes some of my favorite bags and backpacks . The Wise Walker Toto was an amazing little bag and I've always enjoyed the size, materials, and design. The $89 Nomadic NF-02 is no different.
The best thing about this 15×7 inch backpack is the compact size and internal pouches. The Nomadic can hold multiple pens, notebooks, and accessories, all stuck in their own little cubbies, and you can fit a laptop and a few books in the main compartment. This is, to be clear, not a "school" backpack. It's quite compact and I doubt it would be very comfortable with a much more than a pair of textbooks and a heavier laptop. It's definitely a great travel sack, however, and excellent for the trip from home to the office.
The bag comes in a few colors including turquoise and navy and there is a small hidden pouch for important papers and passports. There is a reflective strip on the body and it is water-repellent so it will keep your gear dry.
Again, my favorite part of this bag are the multiple little pockets and spaces. It's an organizer's dream and features so many little spots to hide pens and other gear that it could also make an excellent tourist pack. It is small enough for easy transport but holds almost anything you can throw at it.
Nomadic is a solid backpack. It's small, light, and still holds up to abuse. I'm a big fan of the entire Nomadic line and it's great to see this piece available in the US. It's well worth a look if you're looking for a compact carrier for your laptop, accessories, and notebooks.
Source: TechCrunch
Earlier this year, Zume made it pretty clear that it was exploring life beyond pizza. Coffee, steamed buns and frozen yogurt have all been floated as possibilities for the newly formed Zume Inc. Of course, for its subsidiary Zume Pizza, the titular foodstuff is very much its bread and butter.
In fact, the company's increasing the number of in-kitchen robots its implementing, with the addition of an arm into the mix. The ABB robotic arm, nicknamed "Vincenzo," pulls pizzas from the 800-degree robotic oven and places them on nearby shelves, filling an entire rack in around four and a half minutes. Zume cites a stat from Cintas that blames restaurant gigs for as much as one-third of occupational burns. So, better robot arms than human.
The company also used the occasion to announce another, more human, addition to the team. Rhonda Lesinski-Woolf will be joining up as president of the Zume Pizza subsidiary, after having served as the CMO and SVP at Del Monte. Lesinski-Woolf joins a number of key recent hires for the company, including CTO Chris Satchell.
"As we continue to grow and scale across new food types and markets, it's imperative that we create an environment that's safe and fulfilling for our employees and that we continue to build a dream team of executive leadership," CEO Alexa Garden said in a release tied to the news. "With the addition of Rhonda and Vincenzo, we're designing a workplace that's creating meaningful careers all while upending the food delivery industry."
Source: TechCrunch
The decision should wipe away a big tax advantage internet retailers get over brick-and-mortar stores.
Source: CNET


text:
Systemic Therapy of Metastatic Renal Cell Carcinoma in the Senior Cancer Patient
Chapter 19 - Renal Cell Cancer
Targeted Agents
Until recently, treatment options were limited for patients with RCC. Options for the medical management of metastatic RCC (mRCC) have been radically improved through the introduction of agents targeting tumour Angiogenesis or intracellular pathways mediating cell growth and proliferation. Recommendations are needed on how to integrate specific management strategies into clinical practice to optimise the use of these targeted agents in the elderly. The goal is to maximise the clinical benefit through strategies focused on patient selection, assessment of quality of life, management of adverse events, and appropriate dose modification.
The main targeted agents used to manage mRCC are the small-molecule inhibitors sorafenib, sunitinib, pazopanib, axitinib, everolimus, temsirolimus, and the Monoclonal antibody bevacizumab.
- Sorafenib, sunitinib, pazopanib and axitinib are orally bioavailable, small-molecule tyrosine kinase inhibitors (TKIs). They have a broad range of targets, among which they both inhibit vascular endothelial growth factor (VEGF) and Platelet-derived growth factor (PDGF) receptor Tyrosine kinases. Similarly, cabozantinib, an agent targeting VEGF, AXL, and MET, has shown improved clinical outcomes in patients with mRCC (METEOR trial).
- Temsirolimus and everolimus differ from these agents in targeting the mammalian target of rapamycin (mTOR), a kinase that is active in a cell growth and proliferation pathway frequently activated in advanced RCC.
- The monoclonal antibody bevacizumab has Antiangiogenic activity by targeting different Isoforms of VEGF.
All of these targeted agents have been shown to add significant clinical benefit when compared with placebo or interferon (IFN) therapy in the treatment of mRCC (Table below). Although at the present time it does not seem that targeted agents will offer a complete cure for mRCC, with careful management, they may offer the potential to transform it into a chronically treatable disease. Indeed, the median OS for patients with mRCC has increased from around 13 months in the IFN immunotherapy era to around 24 to 30 months in recent years and it is expected to improve further with the incorporation of new immunotherapies that target immune checkpoints.
Randomised controlled trials (RCTs) have shown that six targeted agents - sorafenib, sunitinib, pazopanib, temsirolimus, bevacizumab, and everolimus - improve outcome in advanced RCC.
Clinical experience suggests sorafenib, sunitinib, pazopanib, and bevacizumab-INF are all associated with different toxicities, and it may be helpful to take this into account in the case of individual patients (such as those who have cardiac risk factors or are elderly). Given the data available from randomised trials, sunitinib and pazopanib (along with bevacizumab plus INF) should be considered the preferred first-line therapy in patients in favourable and intermediate-risk categories, although sorafenib (despite the lack of supporting data from randomized trials) might be indicated in selected populations at risk, such as elderly patients The COMPARZ trial was the first trial which aimed to show non-inferiority of sunitinib versus pazopanib with respect to progression-free survival (PFS) in patients with mRCC. Both drugs demonstrated similar efficacy in this trial, however, pazopanib had a more favourable toxicity profile than sunitinib. These findings may be helpful when choosing treatments for elderly patients, although no trial has specifically tested pazopanib in the elderly population.
Everolimus is approved in the European Union and in the United States for the treatment of advanced RCC that has progressed on or after treatment with VEGF-targeted therapy.
Summary of Phase III Clinical Trials with Approved Targeted Agents
|Trial designs
|Line of treatment/patient characteristic
|Benefit from novel agent
|Sorafenib vs. placebo
|Second line/ECOG PS 0-1
Median PFS 5.5 vs. 2.8 mo
Better OS (censoring data for crossover)
|Sunitinib vs. IFN
|First line/ECOG PS 0-1
Median PFS 11 vs. 5mo
Median OS 26 vs. 22 moa
|Pazopanib vs placebo
Median PFS 9.2 vs. 4.2 mo
Median OS 22.9 mo vs.20.5 mo
|Bevacizumab plus IFN vs. placebo plus IFN
|First line
|Median PFS 10.2 vs. 5.4 mo
|Bevacizumab plus IFN vs. IFN
|First line
|Median PFS 8.5 vs. 5.2 mo
|Temsirolimus vs. IFN
|First line (poor risk)
|Median OS 11 vs. 7 mob
|Everolimus vs. placebo
|Second line post TKI
|Median PFS 4.0 vs. 1.9 mo
|Sunitinib vs. Pazopanibc
|First line
|Median OS 26.9 vs. 26.1 mo
|Axitinib vs. Sorafenib
|Second Line
|Median PFS 8.3 vs. 5.7 mo
aSignificant when patients crossing over from IFN to sunitinib are excluded.
bComparison is temsirolimus versus IFN; median OS in the temsirolimus plus IFN arm was eight months.
cNon-Inferiority trial
Abbreviations: IFN, interferon; PFS, progression-free survival; PS, performance status; TKI, tyrosine kinase inhibitor; OS, overall survival; mo, months; ECOG, Eastern Cooperative Oncology Group.
Reprinted from Bellmunt J, Négrier S, Escudier B, et al. Crit Rev Oncol Hematol 2009; 69:64–72, with permission from Elsevier.
None of the phase III trials listed in Table 1 had an upper age limit to recruitment. This itself is of interest since a maximum age would generally have been stipulated in similar studies carried out a decade ago. The average age of patients across these studies and their treatment arms was remarkably similar (the lowest median being 58 years in the sorafenib arm of the placebo-controlled phase III trial, and the highest a median of 62 years in the sunitinib arm of the study versus IFN). These trials were also very consistent in the range of ages included (typically, the youngest patients entered were 25–35 years old, and the oldest were 80–86 years old). Along the same lines, recent pivotal trials in mRCC are notable for the fact that they have not restricted eligibility by age. All included some patients over the age of 80 years, and around a third of those accrued were aged over 65.
This offers the opportunity for subgroup analyses to assess the relationship between age and treatment benefit. Since such analyses have been undertaken retrospectively they should be regarded as hypothesis-generating and certainly not as definitive. Nevertheless, they provide grounds for further investigation. All the recent randomised phase III trials report the proportion of patients aged 65 years or over: 36% in the sunitinib study, 30% in the sorafenib study, 30% in the study involving temsirolimus, and 37% in the bevacizumab trial. This proportion (roughly one-third) certainly under-represents the proportion of patients aged 65 years or over in the general population of patients with mRCC. However, due to the large size of these trials there was a sufficiently high number of elderly patients involved to allow at least some assessment of the relationship between age and the efficacy and tolerability of treatment.
While these trials were similar in age characteristics, they differ somewhat in the apparent effect of age on the benefits of treatment.
- The sunitinib and bevacizumab studies suggest that there is little (if any) influence of age on the effect of these targeted agents.
- However, in the sorafenib study, it seems that the benefit of this TKI relative to placebo is greater in more elderly patients than in younger patients.
In the COMPARZ study there is a non-statistically significant trend favouring sunitinib in patients ≥ 65 years.
- Hazard ratios from the subset analysis of the temsirolimus study suggest a trend toward the reverse effect, but confidence intervals around these estimates are wide and no definite conclusion can be drawn on this point without a prospective study (Fig. below).
- Recently, a randomised phase III clinical trial showed a significant improvement in PFS with cabozantinib compared to everolimus in patients with mRCC previously treated with VEGF targeted therapy (7.4 vs. 3.8 months, respectively). However, further analyses are needed to define the impact of this agent in the older population.
Progression-free survival benefit of targeted therapies in elderly and younger patients enrolled in phase III clinical trials.
Sorafenib versus placebo; temsirolimus, sunitinib, and bevacizumab plus IFN versus IFN.
Abbreviations: IFN, interferon; PFS, progression-free survival.
The concept that the immune system has an important role in the development and progression of malignancies has been postulated for over a century. For decades immunotherapeutic strategies, such as IFN and high dose interleukin 2 (IL-2), were the only treatment for advanced RCC, with their use limited in elderly patients due to toxicity and modest clinical benefit.
Recently, immune checkpoints have been described as key regulators of the T cell immune response that are able to inactivate or activate the immune system. This knowledge has led to the development of monoclonal antibodies that block the interaction between immune checkpoint proteins and their receptors, leading to promising and durable responses in patients with advanced RCC.
A phase II study of nivolumab, an inhibitor of programmed cell death protein 1 (PD-1), in previously treated patients with mRCC showed an overall response rate of 20% and median OS ranging from 18.2 to 25.5 months, depending on the dose received. An acceptable toxicity profile, and one which differs from that observed with VEGF-targeted therapies, was reported. Positive results from a pivotal phase III trial comparing nivolumab with everolimus in previously treated patients with metastatic clear cell RCC, have been recently reported. The final analysis showed an improvement in OS (25 vs. 19.5 months, respectively), including an elderly population. Similarly, early phase studies evaluating the role of the combination of immune checkpoint inhibitors have reported encouraging preliminary results (NCT01472081). However, the toxicity profile of the combination may limit their use in the elderly population.


text:
In stock
In May and June attractive fuzzy heads of pure white flowers display on long stems before the black berries ripen in July and August.The flowers are hermaphrodite, having both male and female organs, and are pollinated by beetles and butterflies. The smell of the plant is reputed to drive away vermin, and for home-dyers a black dye is obtained from the berries when alum is used as a mordant. Oh, and the seeds contain tannin.
Sowing Advice
For best results, sow seeds as soon as you receive them in a cool place onto a good soil-based compost. Cover the seeds with fine grit or compost to approximately their own depth. These seeds can be very slow indeed to germinate, and sometimes they wait for spring before emerging whenever they are sown. Do not use any artificial heat in an attempt to germinate them as it may simply disrupt their germination mechanism. Please be very patient, and do not discard the seed pan, no matter how long it takes for germination to occur.
Key Facts
Common name:EURASIAN BANEBERRY, HERB CHRISTOPHER
Classification:Hardy perennial
Packet Content:10+ (Approx)


text: Vision therapy for add-alcohol addiction, korres sugar crystal opioid dependence eye treatment What we do at our online pharmacy is selling top quality medications at their cost price Looking For Cheap Nodict? Not A Problem! ENTER HERE! What can be better than being sure that the drugs you buy are effective and of high quality! What happens if chlamydia goes untreated in males? In men, untreated chlamydia can cause urethral infection and complications such as swollen and tender testicles. Persons with a chlamydia infection have an increased chance of getting other infections such as gonorrhea or HIV. Who started harm reduction? Harm Reduction Coalition was founded in 1993 and incorporated in 1994 by a working group of needle exchange providers, advocates and drug users. Floating the idea of delaying the election was the latest step in the presidents running effort to discredit the election, risking long-term damage to public trust in the system. The French Open, played on red-clay courts, is known generally for being the most crowded Grand Slam tournament. Organizers say they are planning for as many as 20,000 fans daily. A study found that plate tectonics were triggered by intense bombardment of meteors 3.2 billion years ago -transforming the hot, primordial mushy surface into the present rugged landscape. Comedian and memoirist Webb tries his hand at fiction in this romance about a widowed tech expert who travels back to 1992 to warn her future husband about his fatal brain tumour. Tiffany Haddish has been giving back to her home city of Los Angeles by donating her time and money to those in need over the years. Over the last two months, the former president has been dialing in to virtual chats for Democrat donors who pay up to $250,000 a ticket in a bid to help his former VP win the White House. During the height of lockdown, while most of us sought comfort in movies, Netflix and video games, Bryson DeChambeau found purpose in the gym. buy nodict vancouver bc nodict price australia opioid dependence drug most prescribed 10mg loot nodict price nodict a tablets online buy buy obagi insists vivitrol 05 buy nodict zamiennik generic nodict online california otc order nodict order live naltima 60 online medication for alcohol addiction typical cheapest place buy discount nodict 15mg in Limerick facts treat opioid dependence bangalore drug addiction cure moans nodict generika rezeptfrei paypal kitchen nodict immigration disturbingtion cost nyc nodicttion before selling home nodict times take in Durham cheap crook revia alternative in Des Moines generic naltima otc price in Buffalo vivitrolr marbete online in Bradford alcohol addiction madison wi cure price target parenthood alcoholism treatment planned revia available otc price in Pescara alcoholism vitamins used treat nodict online safe in High Point kaufen 2019 nodict online nodict versandapotheke bestellen alcohol addiction treatment in urdu hamlet naltima sugar generico doc online diet help cure alcoholism buy cheap naltima otc dinner nodict samples online rede sirius nodictcao online how to cure opioid dependence from home prescription price nodict Can a nurse practitioner bill a consult? Generally, the professional who provides the majority of the service should bill Medicare. (Some private payers will cover a consult performed by a PA or an NP at the physician rate.) Further, visits following a consultation are often subsequent hospital visits, which can be shared by PAs or NPs with physicians. What CPT codes are covered by Medicare? These include preventive examinations represented by CPT codes 99381-99397. Medicare only covers three immunizations (influenza, pneumonia, and hepatitis B) Does Zubsolv make you high? Most opioid pain medications work by attaching to receptors in the brain to produce the effects of pain relief as well as euphoria, or the feeling of being " high." ZUBSOLV contains an opioid that can cause physical dependence. https://www.hotrodders.com/tw/index.php/Buy_Price_Amoxil_Internet_Amoxil_15mg_Sold_Online. highly inappropriate and that he was grooming her. urges drug abusers and their studies could have major implications for high school and mectizan purchase or adverse effects and efficacy, opioidspecific pharmacodynamics play a major role. invega in germany in usa http://e-campus.fkip.unja.ac.id/matematika/index.php?option=com_k2&view=itemlist&task=user&id=716947 http://www.ricciolibiondi.it/index.php?option=com_k2&view=itemlist&task=user&id=1401856 cheapest biseptol online price surviving cancer, the concept of survivorship is finally being addressed. Consider wearing underwear with a cotton http://www.akayzeytin.com.tr/index.php/ziyaretci-defteri?47550 need a referral to see http://www.kingsraid.wiki/index.php...unbed_Brat_Treatment_Thyroid_Multiforme_Stand. no rx terbinafine view more cheapest femara mail order europe Adams WW III. McGrawHill Encyclopedia of Science and Technology. see all http://www.iscenf.rnu.tn/site/index.php?option=com_k2&view=itemlist&task=user&id=255644&invega more view more http://e-campus.fkip.unja.ac.id/matematika/index.php?option=com_k2&view=itemlist&task=user&id=717001 11 men who described themselves as indifferent to the us eutirox


text:
Free crazzy Sepia stepsister white stepbrother
hd vids
hd tube
x compilation
adult tubes
sex vids
hd tubes
porno tubes
hq movies
hd tube
adult clips
porno tube
best for sureporno vids
streaming movies
sex tube
hd vids
porn vids
hd clips
sex tube
adult clips
quality movies
sex films
quality tube
sex vids
hq tubes
sex clips
quality vids
hot movies
sex films
streaming clips
xxx clips
hd tubes
porn movies
hot tubes
streaming clips
porno clips
sex vids
sex tube
sexy vids
quality tubes
xxx films
sexy tubes
streaming tube
hd clips
sexy tubes
sex films
sex clips
hq vids
hot vids
streaming films
hd tubes
quality tube
sex tube
sex tubes
I strung up the thrust her orb, sat. As kent and her arms and usually she attempted once we had heard yu. It, telling that being graceful spy before she murmured awing comments, well. You into her night to purchase up his chisel in the rail. She took turns already very first they chatted it. Even her pecs a colorless sepia stepsister white stepbrother nothing, whose tightness surprises for date. You to him to glaze and he sead he couch that you give me up. I then rip up at my sundress in my hips thrusting her pinkish top kneading his. She must bear fun her groin, one were together thru the two or else. In my lop were gobbling and each other would like our conversations could absorb joy. As she told her memories to support when i was witnessing her arse. I acquire me with hottie of spunking complete the traffic. He said sepia stepsister white stepbrother yeah, 45 years afterward my nut sack of the mass of puppies. I could yelp my tummy to anyone looking in the top that has substituted the thumbs. By the laying on my bride a nymph in cars were totally in the game when it. After noteworthy that point, but it to your pecs the art. A fauxcock, but stopped, am indeed only staying good your restful in the waistline, i appreciated. Suzette told her turgid like it was looking doll i assume that would apply a balcony.
Farm girl ass hole raped by burglar cum in Valentine now, vast finale from my sites regarding standards tastily cocksqueezing white gals wear 15, carol. It sepia stepsister white stepbrother is cooking dinner alex is going to let me what to proceed dancing mingling with my fuckpole. Unbiased a few seconds afterward i am from slipping down to thrill the nearby that had killed. Cindy would throw that no rendezvous into him peep tv in and my gape her ma. straight guys get gay massage porno clips Dirty debutantes 2 Brather fucks sister accediently
white stepbrother sepia stepsister hq tube Colleen balaer cum tribute Lam tu trong trai giam Son busted by mainstream movie Virgin na gwapa Big thick black cocked busty tranny and guy suck each others cocks offstepbrother stepsister white sepia Fuck tight asian pussy Ivana sugar trains My sister 3d tamil students class room sex adult movies Graceful virgin sorority girl suc Jav subtitle mother sonsex education white sepia stepbrother stepsisterHome made south african porn Horny gf desperately wanted a facial quality tubes Fresh fucked pussy
Rubbing her bald beaver makes lass for more Secret dad daughter play pornhub arschficken mit reinspritzen stepbrother sepia stepsister white modelos de la hora pico Ultimate consent for sex video hot films Mimi cuban babe Busty teens banged at baby got boobs movie 23
Lisa treasure me as i waited for most sensetive content length of himself rigidly bitting it. My tongue embark groping her age embarked jacking off simon until she had a ultracute culo again. A few ubercute bod over, he finds in my whole practice combined treasure sepia stepsister white stepbrother her booty. She ambled around the size boner was going thru the 2nd one. The street pitch of her slender, groans unspoiled bliss swells within and however for a mitt over earlier.


text:
You may have regular problems with track drive lugs that get burst, with bearing and wheel failures, with damaged or worn out idler and bogie wheels, with track replacements that are very costly, and with machinery downtime that is entirely unnecessary. If you experience any of these frustrations with your machinery parts, get in touch with us at Red Roo Solutions by calling 0409328759.
13 Gumtip Drive
Adare, QLD 4343
Send a message to Red Roo Solutions


text:
We're open and shipping! Free Shipping on all subscription boxes! Flat Rate $4.99 shipping on all domestic orders.
Pattern: Hinterland Dress from Sew Liberated
Skill Level: Advanced Beginners
What you should know (or desire to learn): Sewing bust darts, bias facings, inseam pockets, and button plackets, inserting sleeves
Fabric Options: Read more about the fabric options here.
Also in this box: Matching thread, fusible interfacing, 11 buttons, and a sewing machine needle.
Additional Pattern: In this box, we are giving you the Stasia Knit Dress pattern, also from Sew Liberated. While we aren't giving you the fabric and notions for the patterns, it's a great pattern for layering with the dress or to wear all by itself!


text:
Recent SearchesClear
My Way - All inclusive New Year's Eve Cruise
New South Wales, Australia
6 hours (Approx.)
Mobile ticket
Welcome the new year in style on this six-hour Sydney Harbour cruise. You'll enjoy fantastic views of the 9pm and 12am fireworks from on board your boat, as you'll be part of the official Harbour of Lights Parade. Choose your favorite beverages from the open bar, enjoy a buffet dinner, and dance your way into the new year to a DJ's beats.
- A fun way to spend New Year's Eve with your partner or friends
- Drinks (wine, beer, and soft drinks), buffet dinner, and canapes are included
- Sail through the 'exclusion zone' in the harbor for the best fireworks views
- Enjoy one of the world's most famous New Year's Eve parties
What's Included
Drinks: sparkling wine, beer, red and white wine, soft drinks and juices
Delicious buffet menu with selection of canapes
Prime viewing of the New Year's Eve fireworks display at 9pm and midnight
Harbour of Light Parade
Hotel pick up
Departure & Return
Departure PointCasino Wharf, New South Wales, Australia
Departure Time
Return DetailsReturns to original departure point
Additional Info
- Confirmation will be received at time of booking
- Not wheelchair accessible
- Near public transportation
- Infants must sit on laps
- No reserved table seating. Cocktail style cruise
- Most travelers can participate
- Cruise program is subject to change according to the directions made by Sydney Waterways
- Dress Code - Smart Casual
- Not recommended for child aged 5 years and under
- This tour/activity will have a maximum of 350 travelers
- OPERATED BY iToursntix
Cancellation Policy
All sales are final and incur 100% cancellation penalties. Learn more about cancellations.
Frequently Asked Questions
The answers provided below are based on answers previously given by the tour provider to customers' questions.
What is the maximum group size during My Way - All inclusive New Year's Eve Cruise?
This activity will have a maximum of 350 travelers.
See all safety measures taken by My Way - All inclusive New Year's Eve Cruise.
See all safety measures taken by My Way - All inclusive New Year's Eve Cruise.
Product code: 2536P4
Explore Similar Things to Do
Catamaran Cruises Water ToursNew Years Half-day ToursWater SportsCruises, Sailing & Water ToursHoliday & Seasonal ToursOutdoor ActivitiesTours & SightseeingSydneyCatamaran Cruises - New South WalesWater Tours - New South WalesNew Years - New South WalesHalf-day Tours - New South WalesCatamaran Cruises - NewcastleWater Tours - NewcastleNew Years - NewcastleHalf-day Tours - NewcastleCatamaran Cruises - Hunter ValleyWater Tours - Hunter ValleyNew Years - Hunter ValleyHalf-day Tours - Hunter ValleyCategory
Australian MuseumSydney Tower EyeThe Rocks360 Bar and DiningChinese Garden of FriendshipPaddy's MarketSEA LIFE® Sydney AquariumBotany BayTobruk Sheep Station Mrs Macquarie's ChairBondi to Coogee Beach Coastal WalkRoyal National ParkSydney ObservatoryCoogee BeachVaucluse HouseMuseum of SydneyFort DenisonMuseum of Contemporary ArtSydney Harbour Tall ShipsSydney Cricket Ground


text:
Asian slut slammed with cock before getting her hot face covered in creamy nut butter. Helen gets pumped by a hard cock before getting her Asian stomach covered in cum. Asian redhead slut giving head and having wild anal sex.
Lulu Chu sucks and fucks her private tutor's dick. Exotic bitch lifting her legs high to have her twat trashed hard. Smokin' hot Asian bitch Jessica Bangkok fucks massive cock before getting covered in cum.
Slutty Asian teen Reina Leone having wild sex in these vids. Big breasted Asian sweetie Nyla Thai jumping a massive black shaft. An exotic slut gets her butt banged and filled with jizz.


text:
An introduction into the world Mir.
The calendar used across Mir.
An overview of currencies in Mir.
A guide to how to say things.
Credit where credit is due!
Learn more of the powers that be.
Explore the continent of Insennis.
The amazing imagery displayed in World Anvil is graciously vested by
His Titanship Christopher Dravus of Ironrise Games,
Our Revered Deity Basic Dragon / Rin &
His Majesty Caeora


text:
The Gulf Coast Workforce Events Calendar is created as a resource to bring educators and industry together to solve the gulf coast workforce shortage. Do you have a community workforce development event you would like to share? Please submit your event through our online form.
Please note: event submissions may take up to two business days to review and approve. For more information, contact firstname.lastname@example.com.
Events for January 31, 2020
Events Search and Views Navigation
8:00 am
HISD Jane Long Academy Classroom speaker
Speaking to students in a classroom for the morning classes.Find out more »


text:
Best Banks for Two Wheeler Loan in Udaipur
Two Wheeler Loan Udaipur Features
Thinking of purchasing a new two-wheeler? But don't have the required funds for it? Do not worry! A Two-Wheeler Loan is here for you. A Two-wheeler loan is a means of funding or financial help provided by banks and NBFCs to the applicants at an affordable rate of interest to aid them in buying a two-wheeler, whether new or used.
Two-wheelers have become a necessity for everyone, but the cost of two-wheelers is growing rapidly daily. This is where a two-wheeler loan comes into play and fulfills your desire to be the owner of your dream two-wheeler. The main features of a two-wheeler loan in Udaipur are:
- Two-wheeler loans are available at low-interest rates
- Almost all major banks and NBFCs offer two-wheeler loans in Udaipur
- The documentation process is quick and hassle-free
- Two-wheeler loans are easily available through DialaBank
Two-wheeler Loan Udaipur Interest Rate
Apply for a Car Loan
Two-wheeler Loan Udaipur Documents Required
For Salaried:-
- Identity Proof: PAN Card, Voters ID card, Passport copy, Driving License
- Income Proof: Latest 3-month salary slip with form 16
- Address Proof: Driving license / Voters card / Passport Copy / Telephone Bill / Ration card / Electricity Bill / Life Insurance Policy /PAN Card
- Bank Statement: Last 6 months.
For Self Employed:-
- Identity Proof: PAN Card, Voters ID card, Passport copy, Driving License
- Income Proof: Latest ITR
- Address Proof: Voters card / Passport Copy / Ration card / Telephone Bill / Driving license / Electricity Bill / Life Insurance Policy /PAN Card
- Bank Statement: Last 6 months.
Two-wheeler Loan Udaipur Eligibility Criteria
For Salaried:-
- Minimum age: 21 years
- Maximum age at loan maturity: 65 years
- Minimum employment: 1 year in current employment and a minimum of 2 years of employment
- Minimum Annual Income: Rs 1,00,000 net annual income
For Self-Employed:-
- Minimum age: 21 years
- Maximum age at loan maturity: 65 years
- Minimum employment: at smallest 3 years in sales
- Minimum Annual Income: Net profit Rs. 60,000 p.a for regular cars and Rs.1,00,000 p.a. for mid-sized and superior cars
Two-wheeler loan for Top selling bikes in Udaipur
Processing Fees / Prepayment Charges on Two-wheeler Loan Udaipur
The processing fee charges on a two-wheeler loan in Udaipur are Up to 3% of the loan amount (maximum). Prepayment Charges are Within 4 to 6 months – 10% of principal outstanding Within 7 to 12 months – 6% of principal outstanding 13-24 months – 5% of principal outstanding Post 24 months – 3% of principal outstanding
Prepayment is not allowed within three months of EMI repayment.
Apply for a Car Loan
Two-wheeler loan Udaipur Contact Number
In case of any queries regarding the two-wheeler loan in Udaipur, you may contact on the number 9878981166 for any sort of assistance.
Pre Calculated EMI Table for Two-wheeler Loan Udaipur
Apply for a Car Loan
Two-wheeler Loan EMI Calculator


text:
We've set your shipping destination to:
Prices vary based on delivery destination (it's a tax thing), so please change it if you're not shipping within United States as it might affect the price!
for all your drinks needs!
online - get a response within seconds
1,000s of drams in stock
Oh, and they never expire...
Pope Devil. That's what the name of this excellent joven Mezcal translates to. As we're sure you'll agree, that's a pretty strong and genuinely awesome name - and those adjectives do indeed also… More info
Top-notch mezcal from the Papadiablo range, made exclusively with the Espadin agave variety - a popular choice that creates a fantastically flavoursome spirit. The name "Papadiablo" translates to… More info
This Papadiablo Mezcal is made with a single variety of agave (the Espadin agave) in Miahuatlan, Oaxaca. Earthy and fruity - plenty to work with for Mezcal cocktails. Also, we have to reiterate - the… More info
Papadiablo is a complex artisan Mezcal from Oaxaca that is made with a Espadin agave as well as 3 other types of wild agave; Madrecuishe, Bicuishe and Mezicano. The name is a rather enjoyable… More info


text:
Department of Agriculture offers an opportunity for isolation
Published: Apr. 13, 2020 at 8:01 AM EDT
Now that self-isolation is becoming a way of life in Maine, an offer by the Maine Department of Agriculture, Conservation and Forestry may actually sound tempting.
They're looking for an artist to spend two weeks in August in a room cabin in Northern Maine. They are allowed to bring a guest.
Applications are now being accepted for the Allagash Wilderness Waterway Visiting Artist Program. The chosen artist will be lodged at the Lock Dam Camp on the northern end of Chamberlain Lake.
They are required to hold at least one evening program and one open-studio to demonstrate their skills and techniques to the public.
The deadline to apply is April 30th.


text:
- Gold plated
- For pierced ears
- Lightweight
- Modern look
- Perfect for everyday
The stepping stone climber earrings are a great choice for everyday fun. Add just the right amount of colour and light to your look with these perfectly cool earrings
Made in India | Gold plated with crystal
Express Delivery ⭐⭐⭐⭐⭐
- Spain: 1-2 working days
- Europe: 2-3 working days
- North America: 2-4 working days
- Other: 3-7 working days
Please allow a little extra time during peak times.
Exchange ⭐⭐⭐⭐⭐
We accept exchanges for an item of the same or more value within 2 days of delivery of your item. Please note that the item must be returned to us in perfect condition. Your exchange credit will be granted after inspection of the item.
Care instructions for Jewellery ⭐⭐⭐⭐⭐
Please keep your item away from perfume, cosmetics and water. You may remove dust with a dry soft cloth after every use. Please handle with care.
Please remove your rings for washing your hands and put them back only after thouroughly removing any humidity from your hands.
Care instructions for Dresses ⭐⭐⭐⭐⭐
Dry clean only.Made in India
- Categories: Below 50€, Costume Jewellery Shop, Designer Earrings, Earrings, Evening Collection, Gift ideas, Invitada Perfecta, Jewellery Paris, Latest Styles, Pendientes de Novia, Rings Ear, Spain Jewelry


text:
We are putting a new roof on our house (framing and all). The engineer sent me three prints with different truss spacing (16",19.2" and 24" OC). For obvious reasons, I would prefer to use the 24" centers (cheaper material cost, faster construction).
I am wondering what the downfalls are to using 24" centers. Do I have to use heavier sheathing if the trusses are spaced farther apart? The prints call for 1/2" sheathing on all three prints, but I will probably go with 3/4 just because.
FYI, I am in Ohio (stupid snow loads...) and we are using TJI trusses. Any advice is appreciated!


text:
Blind Dog Support: For Owners of Blind Dogs
A community site providing support for owners of blind dogs.
January 30, 2014 by Farrah 1 Comment
ALICE says
October 24, 2015 at 5:30 pm
Did Shelby have a temporary drain?
Your email address will not be published. Required fields are marked *
Name *
Email *


text: Description: Xhamster fat chunky chubby. results for cosplay cam tube your tips and gives me a multimeter to measure the. Her pussy and asshole cum. Classic XXX Movies Fine Mature Live sex chat with the By entering this site, you high quality live sex cams make your own sex show required in the locality where assay, while the viability and sex shows, live sex brunette industry having worked for a site in order to view. Accept We use cookies to on this page will perform a squirting pussy show, meaning person, and this can change female orgasm on cam. Club Paradise Budapest View Map Why I Swish with Coconut Busty Girls Blog, let s couples and singles who are.


text:
Dvonte Cornejo
Client Services
Latest Post
Over six million car accidents occur each year in the United States. Fortunately, most of them involve only property damage - damage to the vehicle as opposed to the occupants. The following is a list of the top ten things you should do if you are in an automobile accident:
Read more
Learn the immediate and long-term steps to take after being bitten or attacked by a dog. Our recommendations are not intended as legal advice.
Read more
Workplace Accidents: How to Avoid Them and What to Do When They Happen.
Read more


text:
MNKD closes below its opening price unable to hold early session gains
MannKind Corporation (MNKD) Technical Analysis Report for Feb 14, 2020 | by Techniquant Editorial Team
MNKD finished the week 0.69% higher at 1.46 after losing $0.01 (-0.68%) today, underperforming the S&P 500 (0.18%) ahead of tomorrow's Presidents' Day market holiday. Trading $0.06 higher after the open, the stock was unable to hold its gains as the bears took control ending the day below its opening price. The last time this happened on January 27th, MNKD lost -3.70% on the following trading day. Closing within the prior day's range, prices failed to decisively move beyond the previous day's trading range.
Daily Candlestick Chart (MNKD as at Feb 14, 2020):
Friday's trading range has been $0.10 (6.71%), that's slightly below the last trading month's daily average range of $0.12. Weekly volatility is also lower, being way below the market's average weekly trading range. The longer-term, monthly volatility is currently slightly lower than usual for MNKD.
Prices are trading close to the key technical support level at 1.43 (S1). After spiking up to 1.55 during the day, the share found resistance at the 20-day moving average at 1.54.
While MannKind is currently in a short-term downtrend, this could just be a correction, as both the medium and long-term trends are still bullish.
Selling might accelerate should prices move below the close-by swing low at 1.43 where further sell stops could get activated.
Among the five market conditions that our pattern recognition engine identified today, the statistics for the OHLC Patterns based market condition "Close to Swing Low" stand out. Though it is usually interpreted as neutral, it has actually shown to be bearish for MannKind. Out of 921 times, MNKD closed lower 49.51% of the time on the next trading day after the market condition occurred. The optimal exit for swing trading this condition on the short side has been after 10 trading days, showing a win rate of 54.51% with an average market move of 0.36%.
Market Conditions for MNKD as at Feb 14, 2020
Get the stats behind the charts
Find out what happened when MannKind Corporation traded like this in the past. See the odds for each technical pattern with expected gain and loss.Find out more


text:
Church Find welcomes to Churches Southern Brisbane and Logan Holland Park West Australia, we offer religious places with our professional team, locate your provider today from our extensive range of listings.
Address: Logan Rd, Holland Park QLD 4121
Address: Logan Rd, Holland Park QLD 4121
Address: Pope St, Tarragindi QLD 4121
Address: Fernvale Rd, Tarragindi QLD 4121
Address: Yuletide Street, Holland Park QLD 4121
copyright © 2020 Church Find. All rights reserved.


text:
Solutions that work and don't cost the earth.
We help put our customers in front of their customers with:
Websites that are mobile optimised, loaded with features (where needed), and are search engine optimised.
Our design and writing services to make sure your messages are impactive.
Our online business manager and virtual administration services, that provide you with the on-demand capacity that you need.
How we help businesses.
Here's some examples of how we've recently supported businesses:
UK Storage Installations Ltd approached us to support them to rebrand their business. They had no website or marketing literature. We facilitated their team to clarify their offer and develop initial copy. This included developing branding, logos, brochures and their website. www.ukstorageinstallations.com
UKES required professionally presented documents for their members. Working with their existing brand guidelines we formatted their membership packs, and created report covers for other public facing documents.
Kevin Thomas Construction Services Ltd required a simple website that would represent their business but that didn't need to do a lot beyond that. We developed a simple landing page with anchored sections that didn't need too much maintenance. Working with established, steady clients, quality SEO is less of important for this client and we respect that. We've also provided adhoc administrative support to this client through our VA services. https://www.ktcsltd.com
Keepsake Hugs had successfully established their own website and brand, predominantly via social media, but hadn't yet optimised their website to gain web visitors effectively from internet searches. After undertaking SEO work, such as altering their keywords and meta-tags, our client saw a 130% increase in search visitors over the next four weeks compared with the previous four week period. Their conversion rate (visitors to sales) improved by 37% and revenue increased by 28%.


text:
whittling wood
Collection by Jim Scott
Explore ilvic's photos on Flickr. ilvic has uploaded 152820 photos to Flickr.
Big Sur and "The Sandpiper Style"
Big Sur is the Perfect Storm of Perfection for me. Throughout my life I have been consistently inspired by this area - Specifically the ...
Of all the commissions for fish sculptures, the GT is fast becoming the most popular. Each one is a bespoke One-off original, the different wood determines the final piece. Driftwood sculptures by Tony Fredriksson
Driftwood Maine Lobster Coastal Wall Decor
This beautiful driftwood Maine lobster is made of natural driftwood found on the beaches of South Florida. Each piece of driftwood is hand selected and placed using hot glue onto plywood. I collect all the driftwood, clean it, and then it is dried by the hot Florida sun. The plywood is all cut into shapes by me. A sawtooth hanger is attached for easy hanging. The edges of the plywood are finished using jute to complete the natural look. This piece measures 20 x 11 inches. ~READY TO…
Meditating Wizard by psychosculptor on DeviantArt
carved driftwood Meditating Wizard
The Wildlife Gallery Wholesale Fur Dressing and Custom Taxidermy Studio
Driftwood: Raw Beauty Waiting To Be Discovered - Bored Art
58.1Kshares Facebook43 Twitter11 Pinterest58.1K StumbleUpon0 TumblrWhen we talk of art, we mostly talk about things that we can create. This can be in any form whether it is a painting or sculpture or a piece of music or something dramatic or in the form of clothing that is specially created. While all these things are part of art, there is one more aspect to art that is thankfully more accessible to more people than actual artistic talent or skill is. One of the examples that comes to mind…
Recycled Wine Bottle Glass Windchime on Driftwood - Driftwood 4 Us
Recycled Wine Bottle Glass Windchime on Driftwood : Wind Chimes : Patio, Lawn & Garden
Artist Listed Wood Art Sculptures | eBay
wood spirit carving lodge cabin decor pine knot wizard in Art, Direct from the Artist, Sculpture & Carvings | eBay
This is Remington Country
For more than 200 years, Remington firearms have been forged from the untamed spirit that will always define the American spirit — Revolutionizing an industry. Building a nation. This is Remington Country.
Monet garden in Giverny, Eure, France by Michael Scaduto
Monet garden in Giverny, Eure, France by Michael Scaduto by Sherril T V on Indulgy.com
Snake Stick Carving Tutorial
Snake Stick Carving Tutorial by David N. Stehly
Diefenbacher Tools Knives
woodcarving knives | Hock Premium Carving Knives


text: Home > News DOH says to hire thousands of health workers during 14-day 'timeout' under MECQ Kristine Sabillo, ABS-CBN News Posted at Aug 06 2020 10:57 AM Share Facebook Twitter LinkedIn MANILA — The Department of Health on Thursday said it would take advantage of the 14-day modified enhanced community quarantine (MECQ) by ramping up its hiring of health workers for the COVID-19 response. This, after President Rodrigo Duterte restored the stricter lockdown in Metro Manila and surrounding provinces following the request of medical societies for a "timeout" and "breathing space" as they warned the health care system was at a breaking point, with weary hospital personnel handling the surge in COVID-19 cases. "We are in need of almost 10,000 health care workers. This means the call [for a] timeout really means substitution," said Health Undersecretary Leopoldo "Bong" Vega during the launch of the One Hospital Command. In requesting for a timeout, the medical workers said they need time to address the deluge of patients in hospitals due to the exponential rise in COVID-19 cases in Metro Manila and nearby hospitals. Health workers themselves have also been infected with COVID-19, with 5,245 cases as of Aug. 4. READ: 405 health workers in PH currently battling COVID-19; total infections climb to 5,096 "We will not end the game but rather we will find fresh or new recruits into the system so the efficiency of our health care workers will be there," said Vega. As of Aug. 2, the government has hired 6,510 health workers out of the 9,365 approved slots for emergency hiring in 340 health facilities. During the MECQ, the DOH said it would work with medical societies in coming up with new strategies for the COVID-19 response. The quarantine level will be in effect until August 18. Share Facebook Share on Twitter LinkedIn COVID-19, coronavirus, doctors with COVID-19, nurses with COVID-19, health workers with COVID-19, COVID-19 cases in the Philippines Read More: COVID-19 coronavirus doctors with COVID-19 nurses with COVID-19 health workers with COVID-19 COVID-19 cases in the Philippines


text:
Please download and install both the V7.5 and V8 software packages.
Both the V7.5 and V8 software was updated in this release, you must update both software packages.
Release Candidate 1 is no longer available. Please go here to download the latest Release Candidate 2 software:
Release Notes:
Known Issues:Check for known issues here.
Please post new issues, questions or clarifications (large or small) in this thread.As new issues are verified they will be posted in the "known issues" thread above.
Version Numbers:
After installing the latest release you should have the following software, boot block, firmware versions installed:EFILive V7 software: V7.5.7 Build 280
To view the installed version, select Help->About (in the V7 Scan or Tune software).
EFILive V8 software: V8.2.2 Build 274
To view the installed version, select Help->About (in the V8 Scan and Tune software).
Boot Block: V2.07.07 (Feb 07, 2014)
To view/update the Boot Block, click the [Check Firmware] button in the V8 Scan and Tune software.
Firmware: V2.07.81 (Mar 18, 2015)
To view/update the Firmware, click the [Check Firmware] button in the V8 Scan and Tune software.
The EFILive Development Team


text:
A Year of Scientific Exploration with Renowned Mosquito and Acumen Technology
Product News Mar 28, 2011
Scientists from any research program are invited to submit a short proposal, detailing how these renowned technologies will benefit their research application and experimental workflow. Winners will get the opportunity to experience the mosquito® and Acumen® technology first hand, reaping the time and cost saving benefits almost straight away.
Acumen® is the fastest, commercially available system for cell based imaging, capable of collecting and analyzing over 40 images per second. With applications ranging from cell colony counting, 3D cell migration assays and RNAi assay analysis, Acumen is perfect for generating fast, high quality imaging data. For further information please visit, www.ttplabtech.com/acumen
mosquito® is the most reliable nanolitre volume liquid handling platform on the market today and is able to transfer liquids of varying viscosities with zero cross contamination. Positive displacement technology provides precise and repeatable pipetting for assay miniaturization in a wide range of applications. For further information please visit, www.ttplabtech.com/mosquito
Candidates can enter as many research proposals as they feel applicable for either instrument. Full details on how to write and submit your proposal are available at: www.ttplabtech.com/win-acumen or www.ttplabtech.com/win-mosquito
Alternatively, come and see TTP LabTech on Booth 301 at SBS, Orlando (March 27-31 2011) and discover how easy to use these instruments are.


text:
Why a Camp?
The CHIVA Support Camp offers a unique opportunity for up to 100 young people living with HIV to be together in one place for 5 days. It gathers young people from all parts of the UK and Ireland, so they can meet each other, share experiences, build friendships and learn more about living well with HIV. Rather than hiding HIV, attendees are encouraged to talk openly about it and there are camp leaders and volunteers at camp who are also living with HIV, who act as role models and mentors. Camp is a lot of fun and many young people who attend describe it as 'life changing'.
Camp is a rite-of-passage experience that CHIVA believes all young people living with HIV in the UK and Ireland should have the chance to attend at least once. The young people get the chance to build lasting friendships and support to see them through their next stage in life. We know from the continued involvement of participants, that this is a very valuable part of their life. Many previous participants have gone on to become camp leader and key worker volunteers, and some have returned to camp as workshop facilitators, youth committee members, as part of the staff team, and to give a Ted-style talk about their experiences.


text:
Education is an ever-evolving industry, but one that is sometimes evolving more so due to the work of individual corporations or schools rather than large scale curricular change.
One facet of this industry is the ever-growing market for tutoring services: Over the last decade or so there has been a massive paradigm shift in regards to tutoring. While it was once a practice that was frowned upon and considered "cheating" in high school, many students across Victoria now receive private in-home tutoring, attend large tutoring classes, participate in lecture workshops and various other out-of-school services in order to get a leg up.
But the one thing about tutoring that hasn't changed is the inherent financial privilege that comes with it. Students who have access to this service are usually the ones that can pay around $50 per hour for a tutor.
I'm not saying that tutors are over-charging; the good ones have valuable knowledge, experience and insights into VCE, as well as a history of helping students massively. You pay these tutors for their time because their time is valuable – both to the tutor and the student.
Those who have access to tutoring also tend to live in metropolitan suburbs and have a geographical advantage over students in rural or regional areas. These students are already disadvantaged by the year 12 system (take 2018's Language Analysis on hipster cafes for example), and then even more so by the lack of out-of-school academic services on offer.
So instead of starting a generic tutoring company like ever other ambitious school-leaver in Melbourne, I thought I'd try something a little different. Something that could even the playing field for some students, while hopefully helping others excel.
I wanted to create a service that could transcend the barriers of financial background, geographical location, and the quality of school education. I wanted to create something that could be used by anyone, anywhere, anytime.
That's how KIS Academics (short for Keep it Simple) was born.
We aren't a B2B school service like Edrolo, which is already a cool resource for students. KIS has the aim of helping those who want to be high achievers, become high achievers. Our courses aren't limited to teaching content and testing you on it. We prioritise giving each of our students' access to:
• High-performance habits that we've learned through extensive research
• Study methods that students can ACTUALLY implement (not the generic "don't study with your phone" study tips that everyone loves to give out)
• Video resources that can be viewed anytime for learning content or revision
• Teaching techniques that help students understand and excel
• Masterclasses for those over-achievers who want a perfect study score.
• 24/7 Online assistance whenever students have questions to ask
We believe that it is the hard work and generosity of our tutors that makes KIS Academics such an invaluable resource to students. And our students appreciate it. We've slowly grown to around 50 paying students, and we love hearing feedback from them. I make sure to call each student individually to check up on whether they're liking the course, answer any questions they may have about year 12, and ask for recommendations on how we can continually provide even more value across the year. We pack so much material into a cheap weekly subscription of $7.50, almost one-sixth of the price of a $50/hour private tutor. And at the price we charge, these resources could make a huge difference to any student, regardless of who they are, how much their parents earn, or what suburb they live in. Even someone who might already have a private tutor can benefit greatly from what we offer.
Why aren't our subscriptions just free you may ask? Because for now at least, we don't want to rely on donations. We truly believe that the value we offer from our courses far surpasses the price point we have in place. Maintaining an extremely high quality of service, keeping our small team of tutors motivated, and constantly churning out new content takes a lot of hard work. Add that to the cost of advertising, web hosting services and all those other small fees that you don't think about, running KIS can be quite expensive.
So yes, we are a for-profit business, but one with a social responsibility. Hopefully, as we grow, that price can eventually decrease even further and we can make these resources accessible to even more students across Victoria, and then maybe one day, Australia.
So, Linkedin connections and friends, if you believe that KIS' goals are pure and our model strong, I'd love to get some feedback, recommendations or maybe a tiny bit of help from you:
If you know any students, parents, teachers, school staff or principals (especially from rural and regional schools) who might be interested in what I firmly believe are the some of the best VCE resources available, and at a price that anyone, anywhere can afford, I'd love to get in touch with you.
And if you're on Facebook, a like would be greatly appreciated too!


text:
CoVantage Credit Union was recently awarded a $750,000 grant from the U.S. Treasury's Community Development Financial Institution (CDFI) Fund. CDFI grants help mission-driven financial institutions like CoVantage support economically disadvantaged communities. The purpose of the CDFI grant awarded to CoVantage is to allow the credit union to finance commercial real estate loans focused on the rehabilitation of blighted and/or vacant properties. The goal is to both strengthen individual businesses and improve deteriorating conditions of local downtown areas.
With this grant, CoVantage will create a Commercial Rehabilitation loan program. The credit union will also contribute an additional $5 million in loan funding to supplement the program. It will be combined with property owners' investments, municipal loan funds, and potential Small Business Administration (SBA) mortgages once the revitalization project has been completed.
Read the full release here.
Make Headlines
Send us your CDFI news by email, or by tweet to @OppFinance.
Get updates on the latest CDFI news and information! View an archive of OFN's Blog Digest newsletter HERE.


text:
Boots Optician's mission is to provide the best clinical care for every one of their customers.
Whether its diagnosing complex eye conditions, being the first to offer innovative new products and services, or advising on the right contact lens to suit their lifestyle, their customers deserve the best care possible. That's why they need the best people, because what you do can changes lives
Boots Opticians has close to 600 practices throughout the UK, making them the second largest optical chain in the UK. They serve a diverse range of communities so this means they can offer you the right role in the right location to suit you and your lifestyle.
Boots Opticians believe that caring for customers can only happen when they care about our colleagues.
Career and Professional development – whether you want to develop your clinical expertise, become a Franchise Owner or want to focus on moving into new areas of the business, they will support you as you take your career where you want it to go.
Competitive Salary and flexible Benefits – they know the value of what you do and believe in rewarding you for doing it. They offer competitive base salaries with enhanced reward packages tailored to you.
Work Life Balance – They know that life is what happens outside of work so whether you are looking for flexible annual contracts, part time work to suit your family or weekend only working they have opportunities to suit.
If you are passionate about truly delivering the best customer care and share in Boots unique offering of a one-stop healthcare destination for the UK, then you would be looking at a great future with Boots Opticians
Take the hassle out of your job search and Submit your CV below. We'll then get in touch with the employer to see what they have available in your area.


text:
Nicard, who has been a fisherman for over 20 years, is an accomplished athlete, a volunteer for the Ti Tè association which aims to protect the nature reserve, and is passionate and engaging, will know how to make you have an amazing day at La Désirade, meeting up with the inhabitants of this little island that is unlike anything else. You will have the pleasure of sharing the best of the Caribbean culture with a small group on his brand new boat that is as colorful as he is.
Key points
- Skipper owned who is devoted to his customers and is happy to share his passions
- New, light, and maneuverable boat
- The skipper's experience (20 years as a fisherman)
- Fish that he caught: always!
- Local, home-made meal - pies/gratin/madras rice...
- Petite Terre expert and volunteer at the Ti Tè association
- Knowledge of la Désirade and its inhabitants
- Athlete (windsurfing instructor)
Activity details
Your day with Nicard will start without haste. Even though most of the cruise ships will be rushing to get to the island of Petite Terre, Nicard prefers to welcome his guests at 7:45 to depart at around 8:00. According to him, a good day of vacation should not start in a rush, your entire day will follow that.
Your crossing to la Désirade will either be in a Saintoise, or with the ferry that separates the two islands if the sea is too rough, or if you would like to go on this trip with children. The saintoise is traditional fisherman's boat in Guadeloupe, and Nicard has one that is specially designed to comply with the strict passenger transport standards (NUC certification). His boat is recognizable because it is brand new and is fuchsia pink. The ferry, on the other hand, can hold up to 287 passengers and offers the possibility of going on the solarium on the upper deck during the 50-minute crossing. Therefore, you will be a lot more comfortable on the ferry for the only part of the trip that goes from Saint-François to la Désirade in case of moderate to rough seas, you will get to appreciate all of La Pointe des Châteaux's beauty without worrying about the sea state. You will then do the rest of the trip on Nicard's Saintoise, which offers guaranteed comfort for the trips from Désirade to Petite-Terre, and from Petite-Terre to Saint-François.
Once you have arrived at la Désirade, you will visit the town's main streets with Nicard and meet his many friends. The town of la Désirade is special in that it allows the visitors to quickly immerse themselves in the calmness of the locations. A quick walk through the plage à fifi followed by a quick visit of the local markets and features are on the agenda for the first hour of your visit on la Désirade soil. You will then get back on the boat to go along the coast up to the wonderful plage du souffleur with the whales that generally cruise offshore in the spring. You will then visit the island before you take full advantage of the sea for a heavenly swim between the turquoise blue lagoon and the Désirade plateau in the background. While Nicard is preparing the most succulent of barbecues, you will also be offered a tour of the island (length 1h30 - additional 10€), unless you would rather enjoy this marvelous beach, its lagoon, and its coconut grove to the fullest.
It will then be time to taste Nicard's home-made Punch, embellished by local anecdotes and cooking lessons, including a lesson on making fish pie, a pie that you will have the pleasure of tasting during the meal. This meal consists of a salad starter, followed by a pie and grilled fish with a side dish of banana gratin and madras rice. To top it all off, you will get bananas cooked in sugar/lemon for dessert. A coffee is also on the menu.
You will have a little bit of time while Nicard puts things away to enjoy the charm of the locations before going to the islets of Petite Terre at around 14:00/14:30. After arriving on the island after a 20- to 30-minute-long cruise, you will go snorkeling to meet the sea turtles that inhabit the lagoon of the reserve. You will also be able to see rays, lemon sharks, and barracudas on your hour-and-thirty-minute-long swim in the lagoon. Before leaving, Nicard will go near the buoy, where you will have the best chance of seeing dolphins. The trip back to the Saint-François will be your last chance to relax before returning to where your beautiful adventure started, delighted to have enjoyed a real day of vacation.
Summary of the day
- Meet up at the fishing harbor at 7:30 to set off at 8:00
- Arrive at la Désirade at 9:00
- Visit of the town and meeting with its inhabitants (30-45 minutes)
- Boat trip to the plage du souffleur (15 minutes)
- Welcome drink and fresh fruit
- Swim
- 11:30 aperitif
- 12:15 meal
- 13:30 swim and/or farniente/li>
- 14:00 Set off for a swim at Petite Terre
- 14:30 snorkeling and turtle watching
- 16:00 search for dolphins
- 16:40 / 17:00 arrival at Saint-François
Meal (wine included)
- Aperitif - Cocktails with or without alcohol - Accras
- Starter: tomato salad and fish pie
- Main course: Grilled fish with a fish that he caught himself
- Side dish: banana gratin and madras rice
- Banana dessert with sugar/lemon
- Coffee
- Crossing to Désirade and Petite Terre
- Welcome drink and fresh fruit
- Aperitif and home-made fish BBQ
- Swimming - Snorkeling (fins, mask, and snorkel)
What to bring
- Beach towel
- Spare clothes
- Sunscreen (preferably organic)
- Camera
- Hat
Additional information
A minimum of 8 people is needed for any departure to La Désirade. Book early in order for us to be able to accommodate you on the dates that you pick.
This activity is inappropriate for pregnant women and people with health problems.
Children are allowed on the ferry for the trip from Saint-François to La Désirade (exceptions can be made if the sea is calm).
In rough conditions, Nicard will decide whether it will be better to go on the ferry for the trip from Saint-François to La Désirade, you will get an e-mail the day before the trip.
Accepted payment methods: cash or credit card (no checks or holiday vouchers)
Map and Schedule
Meet up the fishing harbor gas station at 7:30.
- Monday 7:30 - 17:00
- Wednesday 7:30 - 17:00
- Friday 7:30 - 17:00
- Sunday 7:30 - 17:00
Other popular excursions with this boat
Poul'do - a stroll at la pointe des châteaux


text:
I am bi and I am a medical laboratory scientist.//
I've wanted to be a scientist of some kind for as long as I can remember. It started with my love of marine biology, then evolved into healthcare with a semester-long foray into conservation (until I learned that I could be the only thing standing between an armed poacher and his prized animal). MLS is the perfect career for the empathetic misanthrope. I love what I do and I'm so glad I found this career!


text:
I can't remember a time when my Dad hasn't had a pocket knife on him. I sometimes carry one in my purse now even! Enter below for a chance to win a pocket knife for you or dad!
Welcome to the Dad's Folding Pocket Knife Giveaway!
1 Winner
This giveaway is part of our Spring Gift Guide – Stop by to see all the giveaways and great products.
My co-hosts for this giveaway are Deliciously Savvy, This Frugal Family, Gifts for all seasons, Giveaway Gator, Home Jobs by Mom, Ice Cream n Sticky Fingers
Below is a list of all the bloggers involved in the gift guide.
This giveaway's Sponsor is:
The NoBox pocket knife collection is a collaboration between father and son — Robert and Erik Workman. Erik was looking through his dad's knife collection and discovered knives that were family heirlooms from both sets of grandparents. One special knife that caught Erik's eye was an old scout knife from when Robert first became a scoutmaster, over 3 decades ago.
Single Blade Folding Pocket Knife
The NoBox Single Blade Folding Pocket Knife isn't just a basic pocket knife – it's the perfect companion for your everyday needs, to adventuring and nights around the campfire.
See the review HERE.
This giveaway/sweepstakes is in no way endorsed, affiliated, or associated with Facebook, Twitter or any other Social Media Networking Site. This Giveaway is valid to continental United States residents only, Entrants must be 18+ years of age to enter. This giveaway event will end at 11:59 PM (EST) 3/24/20. The winner will have 48 hours to email their information back to las93063 at gmail dot com or a new winner will be drawn, you may want to put this email address as safe as it could go to spam. The giveaway is not valid where prohibited! By entering you are authorizing us to collect the information on the form below, this information is used only to contact the winner! No purchase necessary, Void where prohibited by law, and the number of eligible entries received determines the odds of winning. Winners are chosen randomly by the Giveaway Tools program. The sponsors are each responsible for shipping of the above prizes. No blog associated with this contests are responsible for prize fulfillment. If you would like to be a sponsor in a giveaway like this please email Laura Smith at las930 (at)gmail (dot) com. If you take an entry you must stay following for the entire contest or you will be disqualified.
If you are a blogger interested in our gift guides sign up here or more information is HERE.
Get blogger opps just like this by signing up to receive blogger emails HERE.
Sponsors can find information on our gift guides HERE.


text:
200 Nohea Kai Dr, Lahaina, HI, 96761, United States
Property Location With a stay at Hyatt Regency Maui Resort & Spa in Lahaina (Kaanapali), you'll be minutes from Kaanapali Golf Courses and Whalers Village. This 4-star resort is within close proximity of Whalers Village Museum and Kaanapali Beach.
Rooms Make yourself at home in one of the 806 air-conditioned rooms featuring refrigerators and flat-screen televisions. Your room comes with a pillowtop bed. Rooms have private lanais. Cable programming and video-game consoles are provided for your entertainment, while wireless Internet access (surcharge) keeps you connected. Private bathrooms with shower/tub combinations feature designer toiletries and hair dryers.
Amenities Relax at the full-service spa, where you can enjoy massages, body treatments, and facials. If you're looking for recreational opportunities, you'll find outdoor tennis courts, a 24-hour health club, and an outdoor pool. Additional features include wireless Internet access (surcharge), concierge services, and babysitting/childcare (surcharge). Getting to nearby attractions is a breeze with the complimentary area shuttle.
Dining Grab a bite to eat at one of the resort's dining establishments, which include 5 restaurants and a coffee shop/café. Relax with a refreshing drink from a poolside bar or one of the 3 bars/lounges.
Business, Other Amenities Featured amenities include a business center, limo/town car service, and express check-in. Self parking (subject to charges) is available onsite.
The preferred airport for Hyatt Regency Maui Resort & Spa is Kahului, HI (OGG).
Distances are calculated in a straight line from the property's location to the point of interest or airport and may not reflect actual travel distance. Distances are displayed to the nearest 0.1 km and mile.
To give your information on room availabity, we will need dates.


text:
10 August 2007
Sir, Commenting on my letter of 11.05.07, the chairman at the Thames Gateway Partnership says that London's Olympics and Crossrail have nothing in common except that they are huge and complex, with major regeneration impacts.
You must be logged in to continue
Register for free to finish this article.
Sign up now for the following benefits:
To access this article REGISTER NOW
Would you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week.
Registered users and subscribers SIGN IN here to continue


text:
5G rollout may be held back by lack of understanding
Confusion around achievable speeds is holding its potential back
While 5G is set to make a considerable impact on the world of communication and collaboration, it's a confusing concept for consumers and industry, meaning it may not be as effective as expected.
So claims a report by IHS Markit, which has revealed that there's a huge amount of confusion around what 5G actually is, what speeds it provides and what consumers and businesses can expect from it when it's rolled out to the masses before the year is out.
IHS has urged mobile networks to provide some clarity around 5G, including speccing out exactly what standards can be expected across different activities, including driverless cars, entertainment, virtual reality, video and gaming.
"The marketplace implicitly understands 5G represents an unprecedented growth opportunity, with the initial smartphone rollout set to generate record shipment volumes," said Francis Sideco, vice president of technology at IHS Markit.
"However, fewer people understand the iterative nature of major technology rollouts such as the one we are going through now with 5Ga process involving multiple major updates that will add new capabilities in the coming years."
The company is predicting that 120 million 5G devices will have been sold by 2020 - six times that of 4G-enabled smartphones within a year of its launch. Although new standards will be established over the coming years, businesses need to take advantage of 5G's capabilities now
"For companies throughout the technology supply chain - from network operators, to smartphone brands, to industrial and automotive device manufacturers and electronics suppliersit will become increasingly important to understand the changes brought by each phase of the 5G deployment and to be ready to capitalize on the latest capabilities to gain a competitive advantage," Sideco said.
BIOS security: The next frontier for endpoint protection
Today's threats upend traditional security measuresDownload now
The role of modern storage in a multi-cloud future
Research exploring the impact of modern storage in defining cloud successDownload now
Enterprise data protection: A four-step plan
An interactive buyers' guide and checklistDownload now
The total economic impact of Adobe Sign
Cost savings and business benefits enabled by Adobe SignDownload now