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White willow bark is an ancient herbal remedy for pain and inflammation that has been used for thousand of years. It contains salicin, flavonoids and polyphenols which are responsible for its antipyretic, anti-inflammatory and analgesic properties.
White willow bark works similar to aspirin in relieving pain. In fact, it was the early uses of white willow that led to the discovery of aspirin. Acetylsalicylic acid in aspirin is synthesized from salicin, the primary salicylate in white willow bark.
White Willow Bark For Lower Back Pain (more…)


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Apocalypse Scorpion
$ 3.85
Description: Really great gnarly pods developed in Italy. Great heat on these and the taste is very good. No bitter, or floral or other nasty tones on this one. A great variety to grow and very productive.
Species: Capsicum Chinense
Heat: SuperHot
Seeds: Non Isolated / 10+ Per Pack
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Bahamian Goat
$ 3.75
Description: This is one of the best peppers I have ever grown. Habanero class heat, with great flavor. Pods can be bonnet shaped, some grow stingers. They ripen to orange...
Jay's Peach Ghost Scorpion
$ 3.95
Description: Has to be one of the best superhots a person can grow. Very productive, super wicked shapes, and very nice color. These are very hot and make one of...
Scotch Brains
$ 4.00
Description: Cross between a scotch bonnet and 7 pot brain strain yellow. One of the best tasting peppers I have ever tried. Slightly hotter than a bonnet, less than a yellow...

subset: commoncrawl


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Before you waste your time examining ad tests, you want to ensure that every ad has reach a minimum data threshold.
Within any sample set, it is easy to find a pattern that is caused due to chance. However, as the amount of data you have increases, the likelihood that a statistically significant result is a due to chance decreases.
For instance, if you spin a roulette wheel 4 times, there is a 1/16 chance that it will be black every time. Over the course of 100 spins, you'll likely see 45-55 black results. Over the course of 1000 spins, you'll probably see 475-525 black results. As the data increases, the percentage of times that a result is due to randomness decreases.
In a purely layman's mathematical sense, confidence factors are based upon the fact that patterns in data don't occur based upon random events. Another way of saying this is that confidence factors are based upon the assumption that the data that was gathered during a test will be similar to data that comes after the test – hence you can be 'confident' that the later data will be like the previous data and you can take actions with confidence in your actions.
In a PPC world, we have another factor to take into account – changes in search behavior based on timeframes.
For instance, imagine these three scenarios:
- You just got to work on a Monday morning and start to search for work related items
- It's lunchtime on the last Monday of the month and your rent is due soon and you want to figure out finances
- You're relaxing after dinner on a Monday and you remember something about your day and you want to search more about that item
That's just Monday, yet your Monday evening search probably happened on a mobile phone and your conversion is going to be sending yourself a work reminder to examine the result on Tuesday morning. Your Monday morning conversion was likely to be a whitepaper download or a phone call.
Now, that's just Monday. If you were searching for vacation cruises, your Monday search was thinking about how much you want to escape the office and that same search on a Saturday afternoon might be planning with the spouse on a cruise vacation you plan to buy.
As timeframes change, so does search behavior – this is why we need to take into account not just the data, but the timeframe of the data. You should always use a minimum of a week of data. However, it is fine to use a month or even three months of data gathering before you take action.
This is also why you should define your minimum data before running any confidence calculations.
For instance, this is a test result after 97 impressions:
Ad 2
Ad 3
In purely math terms, we do have a 97% confidence that ad 2 will be a winner. If this was a static data environment where the data that comes later is similar to the data that came before, we might take an action. However, search is a dynamic environment and it's obvious that 97 impressions is not enough data (although, any online calculator will tell you it is).
Here's the exact same test after 3163 impressions:
Ad 2
Ad 3
In this case, all of our ads have almost 1000 impressions, and we're 99.96% confident in our winner (a different winner than at 97 impressions) and thus we can be confident that we can take actions on CTR based testing at this point in time.
At the low data levels, what you really want to avoid is having just one or two people significantly affect your data. For instance, if you have 100 impressions and 1 click, then you have a 1% CTR. If the next 2 people click your ad, your CTR goes from 1% to 2.91% CTR; which is a huge change and can completely affect which winning or losing ad you would have chosen.
When the data starts to grow, then you want to ensure that you have a sample size that is large enough so that a small percentage of searchers can't significantly affect your data, which is why you want a larger and larger sample size the more impressions that an ad test generates within a given time frame.
Minimum Data Recommendations
We're often asked to suggest minimum data amounts. There are times I'm hesitant to give out numbers because not everyone should be using the same numbers.
If you have a brand term that is searched 1 million times a week, you should be using at least a million impressions as your minimum. For many brands, they aren't searched 1 million times in a year, and should be happy with 10,000 – 100,000 impressions before they examine their confidence levels.
These are MINIMUM DATA recommendations. It is OK to use higher numbers than these.
Minimum Data Recommendations for Most Companies:
Low Traffic
Mid Traffic
High Traffic
Well-known brand terms
100 – 1000
Setting Your Minimum Data in Adalysis
As your campaigns are often segmented by brand, product terms, long tail, etc – the ads within each campaign can generally use the same minimum data. We have fairly low minimums in the system as these numbers are the absolute minimum that anyone should use; but we allow you to increase your minimums for the account or for any one campaign (and each campaign can have different minimums) based upon how much minimum data you want to have before you see test results.
Note: We suggest that new users don't change their minimum data right after opening an account. It is useful to start seeing some results and working with the data even if the numbers are low so you can get a sense of your data and results and then raise the numbers once you get a feel for the system.
In your account or campaign settings you can change your minimum data and see all the minimums across your account.
The next time you're thinking about statistical significance or you see someone else's test data, keep the minimum data thresholds in mind. If you see case studies with 40 impressions, the results are as likely due to randomness as a real insight, yet a test with 100,000 impressions is likely due to a real change in your ad copy.
Suggested reading: Working with Statistical Significance: How confident should you be in your test results?


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Endy's April Content Creators On The Rise
Linda Nguyen | Apr. 8, 2019
Spring has finally sprung and we're so excited to celebrate the bright futures of some of Canada's best influencers who are making a splash in the content scene and in their own pursuits too. We've partnered with these content creators to celebrate what they do, and we're honoured that they share their Endy journey with their audiences via #endypartner.
See who we featured in our April roundup below!
Ramsey Aburaneh
"In the midst of all the hours put into [my] side hustle ("work after full-time job work"), it doesn't hurt to be catching up to the lack of sleep on my new @endy mattress 😌💤❤😴"
Head of social media and advertising at Ink Entertainment, keeping himself busy is a thrill and lifestyle for Ramsey. Some trivia: Ramsey was a houseguest on Big Brother Canada 4.
Vanessa Duchel
"J'ai enfin un chum et je peux dire son nom: @endy! Il me supporte, me prends sur ses épaules quand j'en ai envie et je peux même me coucher sur son chest! RIEN DE PLUS CONFORTABLE que l'amour et @endy!
Vanessa is a talented musician and body-positive voice hailing from Québec. Treat yourself by listening to her sing or get inspo from her great style.
Lissa Monet
"My @Endy mattress is finally on my bed frame! I unboxed it and immediately took a nap that lasted a couple of hours it was that comfy. I have to admit, the pillows are really the highlight of my #Endy sleep experience. Super firm and never deflates, I feel like I am sleeping on a fresh fluffy pillow every single night."
An incredible DJ in her own right, Lissa is also the founder of LUXELIFE Sound, an all-female DJ service. Listen to her mixes on Soundcloud.
Miguel Rodriguez
"I've missed waking up every morning thinking 'that was the best sleep ever' but now, once again, I'm finally home loving every second on my @endy 😍 // It's been pretty hard to get my first one hundred sleeps since I've been exploring and adventuring away from home for the last few months, but I must say I definitely get the best sleeps when I'm home 🏡"
As a creative consultant, photographer, videographer, model, and more, you'd be hard-pressed to find something creative that Miguel can't do.
Carly Malchuk
"Being a blogger and social influencer I'm literally ALWAYS on my phone. Thankfully my @endy mattress is the perfect place to unplug and unwind. (Ps I know I've said it before but they're Canadian! It just feels so good to support a fellow Canadian!)"
Carly keeps busy as a fashion, decor, and travel blogger from Kelowna, B.C. while being a mom to Lacie Boo. Check out her website, Carly Daily, for fashion trends and home refresh tips.
Read next
7 Best Nightcap Recipes
The nightcap can be your best friend when it comes to sleep, but just make sure you 'cap' it at one.
11 Best DIY Headboard Ideas
Your bedroom should be your sleep sanctuary, and however you choose to style it for ultimate comfort and snoozing is all up to you.


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Computer systems running Windows OS is the most widely used digital machine across the globe in the today's digital era. These systems contain hard drive where data is stored in the FAT and NT file systems. Sometimes it happens that the data gets lost from the hard disk drive of the system when the Recycle Bin is emptied by deleting the files. At such critical situations when recovery of lost data is the prime necessity, arises the need of a proper procedure that can recover lost data from emptied Recycle Bin. This is because the files might have been deleted by mistake or knowingly not knowing its importance at that time. The query also arises whether it is really possible to recover permanently deleted data from the system hard drive.
Is It Really Possible to Retrieve Deleted Recycle Bin Files?
It is a prevailing myth that when data is lost due to file deletion from Recycle Bin it cannot be recovered but it is not always true. So the answer to the query is yes; it is possible to retrieve data even if files are removed from Recycle Bin. But the answer to this question has two aspects that would confirm whether data lost due to deletion of files from Recycle Bin can be retrieved or not. So the question arises as how to recover lost data from emptied Recycle Bin of Windows system. Before discovering the way out to retrieve permanently deleted (Shift + Delete) data, read further to know more about lost data in Windows OS.
Know Windows File Deletion In Detail
When a file is deleted by clicking on the command 'Empty the Recycle Bin', all the files get lost and cannot be found at any location on the system. Hence, many people think the file is permanently gone and can never be regained. Even the Windows Help Menu tells that "Deleting an item from the Recycle Bin permanently removes it from your computer." And it is true that Windows does not provide any option to recover lost data from emptied Recycle Bin.
But it is not the case that files cannot be recovered, because when files are deleted or emptied from Recycle Bin, actually they are not lost from the machine. Instead, these deleted files get saved on hard drive of the system as raw data. Only when the raw data gets overwritten they disappear forever. So, it is definitely possible to recover the data files with the assistance of external tool as long as they are not overwritten.
Suggestion: Stop using the computer hard drive which will prevent overwriting the deleted files which are actually not lost until they are overwritten.
Recover Lost Data From Emptied Recycle Bin – Key Towards Success!
A steadfast tool called Hard Drive Data Recovery software is a highly efficient application that can successfully retrieve lost files from Windows computer system, even if gets emptied from Recycle Bin. In addition to this, the tool has the ability to recover even formatted hard drives of both FAT and NTFS partition.
For More Detail : http://www.windowsfilerecovery.com


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Advanced vehicle charging station search.
It turns out that Google Maps will display now points where the nearest electric vehicle charging stations are located. The function will certainly not impress those drivers who drive cars with engines based on fossil fuels. However, a handful of "electricians" should be delighted.
The giant from Moutain View is not limited to selecting stations. Google was also tempted to filter the results by … plugin standard. There will be six of these to choose from – J1772, CCS (Combo 1), Type 2, CCS (Combo 2), CHAdeMO and Tesla. There is no denying that this option can make life much easier for drivers.
Someone may criticize Google's actions as "premature". Without taking any steps, however, it is difficult to talk about progress in the development of the electric car market – so it's nice that the company is doing something in this direction now.
Source: 9to5google


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This online resource from the European Commission's website on 'How to choose the right mix of tools' is an evaluators toolbox. It provides suggestions on how to identify the right combination of tools in order to answer evaluation questions. The resource can be viewed in English, French, Spanish or Portuguese.
- What type of tools?
- When to use which tools?
- What combination of tools?
- What specific constraints and requirements
- Check list for the tool's implementation
- List of the tools
EuropeAid Co-operation Office (2005) Toolbox, European Commission. Retrieved from http://ec.europa.eu/europeaid/evaluation/methodology/tools/too_mix_en.htm
Also via mymande
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Reasons to Ditch Mom Guilt
Posted on Jan 19th 2020
Whether you're a stay-at-home mom or a working mom, "mom guilt" is an experience you've likely gone through at least once. As mothers, we often feel overwhelming pressure to live up to the expectation of perfection, and if we don't reach that fictitious goal (which, let's be honest, we never will, and that's ok!) we fall into a pit of regret, doubt, anxiety, and shame. Ironically, this pressure is likely a sign that you're already doing a fantastic job in motherhood. If you weren't, would you let the worry of constantly screwing up eat at you the way it does now? Mom guilt hangs over many mothers, and it's no surprise with the precious responsibility we bear to raise tiny human beings into responsible adults, but you can't let it haunt your every thought. It's ok to admit that you can't do everything! Here are some reasons to remind you to ditch the mom guilt when it gets to be too much, brought to you by your friends at Romp n' Roll!
Giving the Gift of Experiences this Holiday Season
Posted on Dec 20th 2019
Pricy, flashy gifts have become the go-to for Christmastime, and parents frequently shell out a lot of money for these presents (according to this 2017 study by RetailMeNot, U.S. parents spend an average of $330 per child for Christmas), but is this method of Christmas the most meaningful for you children? Perhaps it's time to re-evaluate the gifts your child receives at Christmas. Instead of the newest toy that will be forgotten a few months down the line, consider giving your child the gift of experiences this holiday season, brought to you by your friends at Romp n Roll.
How to Parent Positively Instead of Negatively
Posted on Nov 18th 2019
While parenting is one of the most rewarding jobs you could ever do, it's also one of the toughest. When you and your child clash, it's your duty as a parent to develop and utilize parenting strategies to help your child learn and grow in a positive way to foster understanding and compassion, rather than in a negative way that could lead to them experiencing further issues with anger, confusion, and conflict. Here are some of our most useful strategies to help you positively approach the more negative moments of parenting, brought to you by your friends at Romp n' Roll.
Healthy and Fun Snacks for Toddlers and Kids
Posted on Oct 21st 2019
Parenting is a round-the-clock job, especially the nonstop job of keeping your children fed. Growing kids need lots of food to fuel their high-energy. Thinking up healthy yet yummy snacks for them each day is a lot of pressure, so it's easy to get caught in a rut of making the same rotation of snacks over and over again. But this could be depriving your child of a wider variety in nutrition, and cause them to be picky eaters of only a few foods. Giving them options beyond the usual goldfish crackers and cereal (though both of these are great snack options!) will benefit them both nutritionally and developmentally. Here are some of our favorite healthy snacks for toddlers and kids that are easy and fun, brought to you by your friends at Romp n' Roll.
Unique Kids Enrichment Center and Gym Tumbles into Houston, TX Market - Wilmington
Posted on Oct 15th 2019
Romp n' Roll of Wilmington is proud to welcome the new Katy, TX location to our family! This marks our first location in the state of Texas, a key growth market for Romp n' Roll, and home to over 2 million children ages 5 and younger. A modernized kids gym, they will continue to offer a variety of fun and educational classes, camps, birthday parties, and special events, using unique, play-based learning curriculum for children ages 3 months through 5 years old.


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Former Publisher Dean Martin to assume Group Publisher role over other Babcox Media brands.
Babcox Media, Inc. is pleased to announce that Jim Merle, Group Publisher, will be assuming responsibility for the Tomorrow's Technician brand, effective Oct. 1, 2018.
Merle joined Babcox Media in 1993 as a regional sales manager and was later named publisher of Brake & Front End, ImportCar, Underhood Service, Shop Owner and Servicio Automotriz.
"Tomorrow's Tech is a natural addition to the Tech Group portfolio; it speaks directly to the next generation of automotive service professionals," said Merle. "I'm excited to get in front of the students and share in their passion for the industry. We have a lot to offer to advance their skillset and careers."
Tomorrow's Technician assists instructors and educators with a real-world supplement to classroom assignments. It is designed exclusively for a core target audience of automotive students and expands on the technical experience of its readers. Carley Hull will continue in her role as the brand's Editor.
Dean Martin, former Group Publisher of Tomorrow's Technician, will be assuming a Group Publisher role over other Babcox Media brands including Fleet Equipment and Tire Review.
Bill Babcox, President and CEO of Babcox Media, said, "We're proud that the Tomorrow's Technician brand is a considered a valuable resource for the educators at accredited training programs. The technical content that Jim and his team can provide the next generation of technicians is top-notch. I'm looking forward to seeing the brand continue to evolve its cross-platform offerings."


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Because of the privilege and authority God has given me,
I give each of you this warning: Don't think you are better than you really are.
Be honest in your evaluation of yourselves,
measuring yourselves by the faith God has given us.
I was in the presence of someone who was fighting addictions. The default thing for me to do was to look at them and think I was better than them. But a few seconds later I realized I was no better than them. I was fighting my own addictions. That day I had just deleted my instagram and facebook apps from my phone.
Now there is absolutely nothing wrong with social media apps. The problem was what I had made them to be. I realized I had a major problem with sitting still and enjoying the moment and/or the current environment (Are you able to seat still and not have the urge to constantly have your phone in your hands?) I constantly wanted to see what people were posting. I was perturbed by the frequency at which I checked my phone. My phone had become like my baby. I had to know where it was at any given moment. If I had to put it in my bag, it was the first thing I checked the moment I settled down. Concentrating in church had become an uphill task, because it meant sitting still for TWO hours without checking what was going on in my apps.
What I found most alarming was the frequency at which I kept checking my apps when I had posted something. I am embarrassed to admit I have constantly checked who 'viewed' my status or who 'liked' my status. This to me revealed my addiction to affection. The need to be affirmed. This need was interfering with me. Sometimes I will want to post something but convince myself not to do it I'm thinking if I post this what will they think of me. When I think about it, it is just amazing the things I have failed to do or done because I feared rejection.
Do not judge, or you will be judged.
I know this is one of the most controversial verses in the church today. It is easier to share my 'affection addiction' because in the eyes of the society and my Christian community it is 'acceptable'. I wonder if I would be extended that same kind of grace if I was writing a different story, a less acceptable sin like substance and sex abuse? But what's the difference? It is all idol worship.
I know we have all struggled with something in our lives and yet because we compare ourselves with others we feel at least I don't do that as if the standard were them. Judging is what religious people do and it stems from a place of pride. That kind of pride prevents you from seeing and repenting from your sin because the focus is on another's. Deep inside our hearts we are acting just like the pharisee who prayed 'Lord I thank you because I am not like that tax collector.'
Zacchaeus did the unthinkable sin at that time. Being a tax collector was the equivalent of modern day fornicator. He had lived with pharisees all his life. He was detested and shunned by the community he lived with. But when he finally met Jesus, for the first time Zacchaeus felt loved and not judged. Jesus had all the right as the Son of God and being the most perfect man to have walked on earth to judge Zacchaeus but He did not. That kind of love and not judgment leads to true repentance. We think if we shame people they will change but that is completely untrue.
I have not always felt like this. I have been like the prodigal brother, jealous and without mercy to those who were stumbling and those who were returning to the fold. But my shortcomings have humbled me. I have also been on the other side, being the prodigal son and experiencing reckless love from the Father. Thank God the prodigal brother was not the one who received the prodigal son because maybe we would not be having that story.
Because judgment without mercy will be shown to anyone
who has not been merciful. Mercy triumphs over judgment.
We have to learn to show mercy. Showing mercy is not the most natural thing to do. It only comes from a place of constantly being in His presence and learning at His feet. Those who stay in His presence do as He does. God is a God of mercy. He has not dealt with us as our sin deserves. And if He has dealt with us this way then we ought to replicate that kind of love and mercy.
I am not perfect and I am truly repentant of times I have felt and treated others like I was better. Truly I don't think there is attaining perfection while we are still here on earth. I am aware there is a lot of argument on 'Thou shall not judge'. But I believe the solution is in looking up to Jesus. The standard is how He dealt with people while He walked on earth.
No one deserves my judgement.


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And remember that friends who organise things on Facebook aren't proper friends anyway.
Cunt.No, really.I used to hate the word. All the connotations to sexual politics and such.But now I think I like it. (Not so much as an expletive, but as a word that describes what it is).It's so short, pithy and neat. Sounds good too.YMMV.
Supernumerary.Tump and the related mump.
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Hippopotamus has a spotamus . . . on her bottomus! One by one, all the animals around her give hippopotamus their hilarious diagnosis. 'It's a blister!' said her sister. 'It's measles!' said Weasel. 'It's hippopox!' said Fox. 'It's a trapped hair!' said Brown Bear. 'It is … [Read more...] about Hippospotamus – a Tacos Classic
Bronte Me and my boots – a tacos review
Bronte's not too big for her boots. In fact, Bronte's boots fit just right. Perfect for adventure. Perfect for time with family, and time with friends and running and jumping and learning and working and playing. Perfect for just being Bronte. Written in amazing verse, … [Read more...] about Bronte Me and my boots – a tacos review
Rose Stanley Interview
Today's special guest has worked in New Zealand schools for the past 12 years, providing pastoral care for students experiencing challenges both emotionally and socially. She is a trained companion for the Seasons for Growth Programme which provides education for students on ways … [Read more...] about Rose Stanley Interview
Three – a tacos review
Three is number 1 by me! I have a new hero, a new favourite character, and his name is Three. I couldn't help being drawn in by his charismatic charm and optimistic view of the world. Three has the most endearing nature which sees him thrive in the big city among … [Read more...] about Three – a tacos review


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Meet the Trainer
Lisa started her riding career as a wee little 6 year old on a ploddy old trail horse in rural Illinois. It didn't take more than 1 ride before she was hooked. Competing in western pleasure and hunter/jumper through her younger years on her first horse, Bopper, the appaloosa. Her teenage years took her to the next level, into the exciting world of eventing. She met her heart horse, Harry, a 4 y/o Thoroughbred x Shire that was, at the time, steel gray and dappled. He stood a whopping 17.3 hands, which worked well for a 5'10" teenager with long legs. They competed through Training level eventing and 2nd level dressage. Lisa had a 2 year apprenticeship while in high school, learning the fundamentals of retraining off track thoroughbreds and rehabilitating upper level injured dressage horses. She began teaching lessons to kids and adults at 18 before her life's path moved her and Harry to North Carolina.
The move wasn't easy. And it wasn't always blue ribbons and sunshine. After working as a stable manager in Blanch, NC, she started her own boarding and training business. Unfortunately, the downfall of the economy in 2008 had an impact on horse owners everywhere and training was not in high demand. While on hiatus, and pursuing other career goals, Lisa took on learning the fundamentals of natural horsemanship from several of the world renowned horse trainers such as Buck Brannaman, Clinton Anderson, and Chris Cox. Entirely self-taught and learning a lot the hard way, she progressed to breaking, training, and selling horses locally as safe, sound prospects, ready to go into any discipline. Harry and Lisa have been out of the show ring since the birth of her youngest son. But in due time, they will be back in the spotlight.


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From 2012.igem.org
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Our human practice project includes two themes addressing many very different questions.

Our human practice project includes two themes addressing many very different questions.
The first ones are about various intellectual property issues. The other theme relates to the popularization of sciences and more specifically to our contribution to the researchers' night.

The first ones are about various intellectual property issues. The other theme relates to the popularization of sciences and more specifically to our contribution to the researchers' night.

We have chosen to divide the theme "intellectual property" into two parts because this theme is the main part of our reflexion and it required a longer development, but also because we collaborated with the University of British Columbia on this theme and an entire part seemed necessary to explain our work.

We have chosen to divide the theme "intellectual property" into two parts because this theme is the main part of our reflexion and it required a longer development, but also because we collaborated with the University of British Columbiaon this theme and an entire part seemed necessary to explain our work.
As a summary : the first part deals with the intellectual property rights inference towards the iGEM contest and is made up by a reflexion on the economic challenges the synthetic biology industry faces. The second one sums up our collaborative work on the intellectual property with the UBC iGEM team. And the third one quickly presents our scientific popularization involvement.

As a summary : the first part deals with the intellectual property rights inference towards the iGEM contest and is made up by a reflexion on the economic challenges the synthetic biology industry faces. The second one sums up our collaborative work on the intellectual property with the UBC iGEM team. And the third one quickly presents our scientific popularization involvement.

Revision as of 03:35, 27 September 2012
Our human practice project includes two themes addressing many very different questions. The first ones are about various intellectual property issues. The other theme relates to the popularization of sciences and more specifically to our contribution to the researchers' night.
We have chosen to divide the theme "intellectual property" into two parts because this theme is the main part of our reflexion and it required a longer development, but also because we collaborated with the University of British Columbia on this theme and an entire part seemed necessary to explain our work. As a summary : the first part deals with the intellectual property rights inference towards the iGEM contest and is made up by a reflexion on the economic challenges the synthetic biology industry faces. The second one sums up our collaborative work on the intellectual property with the UBC iGEM team. And the third one quickly presents our scientific popularization involvement.
Part I: Intellectual property issues
IntroductionFree knowledge sharing is part of the foundational principles of the iGEM contest. Consequently, protecting the possible commercial uses of the iGEM team members' projects seems difficultly feasible by common ways (especially patents and copyrights). However, the intellectual property rights in general and patents in particular are commonly known to be the only way to promote innovation in a profit-making logic: if companies cannot secure the economic outcome of their investments in R&D, they will not invest in it. A simple conclusion could then easily be drawn from these very statements:iGEM projects would be unlikely to be industrially and commercially developed, to the extent that it would be difficult for companies to capture the economic returns of their investments.
Nonetheless, the decision of opening an iGEM entrepreneurship division, whose objectives are clearly to optimize the economic opportunities given by the performing iGEM innovation system, vigorously shook that very last conclusion.
The aim of this human practice project is to show that patents are not the only way, not even always the best mean to promote innovation. Viable alternative models do exist, such as the "Common's system", which will be discussed further on. We will assume the iGEM team members form a commons similar to the Open Source community of the IT sector to strike up a reflexion on the development of alternate economic solutions to patents.
The patent system: an efficient economic model ?
Nonetheless, such a profit-making privilege has a cost for both the claimer (patent offices fees, attorney fees, translation expenses if necessary, and so on) and the society, namely the "monopoly rent" it generates (see below). Indeed, targeted invention have to meet tough conditions for a patent to be granted. Consequently, knowing the granting conditions is very important to fully understand the patent system.
A patent is granted:
- for a new invention never publicly revealed, which can lead to industrial applications ;
- on a precise territory ;
- for a maximum of twenty years ;
- to the one who revealed the invention and described it with enough precision.
NB : A patent has to be paid annually for its delivery and maintaining.
The 1930 plant patent act marked the beginning of a new economic era for biology as emerged with it the patentability of the living world. Nowadays, even the genetically modified bacterias may be patentable (the latter have been patentable in the USA and then in Europe since the beginning of the 80s even if the precise conditions to be met to make "living things" patentable remain quite fuzzy.).
The goal of this brief study though, is not to discuss this matter.
Instead, the justification for patents became quickly socio-economic. Patents are now conceived as an incentive for production and knowledge spreading. When a patent is awarded, the description of the invention goes public, in exchange for a maximum twenty-years commercial monopoly to the owner.
Patents are actually supposed to promote innovation and the disclosure of technological knowledge, which means allowing the latest inventions to be known by anyone, though their commercial use is forbidden without a license from the patent owner until the patent ends. On the one hand, the benefits that patents are expected to offer to society are very clear as their design is specifically supposed to improve the global technological level. Indeed, huge technological steps have been made since the patent's creation (although it is not the only factor). On the other hand, stimulating the competition FOR the market (i.e for "new" markets) by granting some kind of monopoly rents generates economic costs for society, which derive from a weakening in the competition IN the market (i.e. in the "same" market).
As a result, the patent system rests on a socio-economic balance, in which society is supposed to be beneficiary. Nevertheless, as we will further see, this balance is fragile and depends on the answers to the following questions :
- What is the patentability scope ? What can be patented ? ;
- How patents are granted ? (i.e. the toughness of the conditions required) ;
- What are the rights of the patent owner ? ;
- How long do these rights last ?
For instance, narrow patents are sometimes granted to different companies on very specific elements, the gathering of which may be necessary to develop an innovation (a new product for example). Nowadays, major worldwide companies use patents as defensive or offensive tools to block competition by preventing (potential) rivals to use specific useful components.When powerful enough, these rivals strike back by doing the exact same thing on other components so that they are mutually blocked. This case is known as the "patent thicket" problem. As an example Google has recently bought Motorola Mobile and its 17000 patents for 12 billion dollars, which means they spent a lot of money to get these patents probably as offensive / defensive ends instead of spending it into pure R&D. Consequently patents sometimes paradoxically discourage innovation.
Contrary to the previous case, some patents may protect wide discoveries (also known as foundational patents). For instance, the patent granted to Myriad genetics covered the whole gene functions of BRCA1 and BRCA2 and all applications that could follow on possible ways to diagnose and cure breast cancer. This kind of patent stood against innovation, preventing any creative use of those genes by any other actor than Myriad Genetics, or leading to any other use linked to this DNA sequence (possibly there would have been many, considering the complexity of biological regulations).
Last but not least, the philosophical questions raised in the last two centuries concerning patents are to be considered. As this is not a philosophical essay, we will content ourselves with a brief resume. According to the American economist Thorstein Veblen (1908), a patent is illegitimate as it privatizes a collective work any invention crucially depends on the previous ones : how would a trolley have been invented if the wheel had not been invented before ?. Veblen emphasizes this idea when he argues that:
This thinking still applies nowadays on different themes. So the question remains : why should a sole actor gather all the economic benefits from this collective process?
Consequently, in some cases, having an economic alternative to the patent system may actually be a good thing.In this perspective the leading economists Claude Henry and Joseph Stiglitz assert that :
In a recent paper, Claude Henry and Joseph Stiglitz (2010) argue that the open source system, which has been widely used in the IT sector, can be an alternate solution to the patent framework to promote innovation.The aim of our approach is not to precisely characterize the way the "open source approach" could be adapted to the synthetic biology. It is to urge the iGEM community to embark on a collective reflexion on its contribution to the development of a "synthetic biology commonns".
The Commons: an alternative model
The open source software's users have been in ever greater numbers for the last few years. According to a study made by Markess International in France in 2009, on 160 French companies 92% used open source software during that year. The viability of its mere founding principle explains its success : the involved software can be used freely with a license ("open source license") authorizing it and even allowing its source code to be modified and enhanced by the licensed one. At first glance, such a model would seem to be inefficient as the software should not generate any profit : their license makes them indeed free to use. However, companies have opted for a business model involving services and proprietary software ("proprietary bricks") that complement the open source product.
Besides, the mere nature of this emerging sector makes it very innovative : a whole community back it up by enhancing the software's source codes. This system also allows companies to make profit on a patent-free position. That is why such a successful example could serve as an inspiration for our reflexion.
The commons' management has been belittled for a long time. Indeed, since the biologist Garett Hardin published his famous article entitled "The tragedy of the commons" in Science in 1968, the negative arguments he gave against the commons have tarnished it. Hardin postulates that one pursues its own interest and as a consequence if a resource (e.g. a pasture) were to be exploited freely by anyone, it would rapidly be destroyed as everybody would try to take the best slice out of it. Hardin concludes : "Ruin is the destination toward which all men rush, each pursuing his own best interest in a society that believes in the freedom of the commons. Freedom in a commons brings ruin to all."
However, Elinor Ostrom's (1933-2012) work, which led her to win the Nobel prize in economics in 2009, broadened the economists' mind on this particular topic.
Her study made her precise the commons' concept. Throughout many examples, she ended up characterizing it as a "jointly owned legal set of rights". Besides, in contrast to Hardin who offered only two solutions (privatization or nationalization) to the supposed "tragedy of the commons", she distinguished this form of property and management of resources from both traditional private (market, companies) and public (planning, State) economic approaches: each community managing a commons fixes its own rules by defining a governance frameworkl and some "bundles of rights". The latter which specifies the access, withdrawal, management, exclusion and alienation rights are distributed to the different actors exploiting the resource in order to manage it jointly, and efficiently according to a defined hierarchy.
Ostrom insisted on the uniqueness of every case of commons she (or her students) studied. Nevertheless she succeeded in identifying a set of founding principles each sustainable commons fits.
- "clearly defined boundaries should be in place
- rules in use are well matched to local needs and conditions
- individuals affected by these rules can usually participate in modifying the rules
- the right of community members to devise their own rules is respected by external authorities
- a system for self-monitoring members' behavior has been established
- a graduated system of sanctions is available
- community members have access to low-cost conflict-resolution mechanisms"
The huge energetic and environmental challenges every country will have to face in the following years call for institutional and organisational innovations capable of promoting the development of relevant technological innovations. The success of the open source movement in the software industry tends to support the idea that patents are not the sole way to support knowledge spreading and technological innovations in an economic sector. Building commons can be considered, to some extent, as a fruitful alternative to the patent inflation and its pernicious effects.
The iGEM community, as a group sharing knowledge on synthetic biology, can be regarded as a case of commons. But, as Elinor Ostrom's work highlights, it is the responsibility of every commons to define its own founding principles, namely a governance framework and an appropriate distribution of "bundles of rights" associated with different roles in the organization of the commons. Even if some milestones have been set, much remains to be done in this respect.
Consequently, we propose the iGEM community to develop a genuine reflexion on this important matter in order to form a strong "synthetic biology commons" whose technological and economic success could be compared to the open source movement.
The results of the UBC team's survey, to the analysis of which we have collaborated, confirm that most of the iGEM community members oppose the patentability of the BioBricks designed in the frame of iGEM. Promoting the intellectual as well as economic value of iGEM outcomes, without resorting to the traditional intellectual property regime, should thus interest most actors in the iGEM commons.
- Thorstein VEBLEN (1908). "On the Nature of Capital. I. The Productivity of Capital Goods", The Quarterly Journal of Economics, Vol. 22, No 4, pp. 517-542
- Garrett HARDIN (1968). "The Tragedy of the Commons", Science, New Series, Vol. 162, No. 3859, pp. 1243-1248
- Charlotte HESS and Elinor OSTROM (2006). "Introduction: An Overview of the Knowledge Commons", pp. 3-26. In Charlotte HESS and Elinor OSTROM (eds). Understanding Knowledge as a Commons, Cambridge (MA), The MIT Press
- Claude HENRY and Joseph E. STIGLITZ (2010). "Intellectual Property, Dissemination of Innovation and Sustainable Development", Global Policy, Vol 1, No. 3, pp. 237-251.
- Learn more about Joseph E. Stiglitz and Elinor Ostrom's Nobel prizes : click here or here
Part II: Collaboration with UBC : IP issues encountered by iGEM teams
The University of British Colombia team was also interested in intellectual property issues. They sent to each team a survey to understand what kind of IP issues are encountered by iGEM teams? Do IP issues hinder iGEM project? What level of IP knowledge have iGEMers? We were glad to see we were not alone on IP planet, so we contacted them to share our works. UBC has accepted to give us their survey results and in exchange we commented their poll and their FAQ, we also answered their survey.281 iGEMers had answered the survey when we treated it .
This collaboration allowed us to broaden our reflexion to iGEM teams' issues.
- Do you have a past experience regarding the IP ?
- Was your past experience in the context of a past iGEM project or outside of it ?
Only a few iGEM participants experienced dealing with IP issues. However, it would have been interesting to know their age in order to know if both data were bounded.
Besides, a patent experience seems to be often linked to a different project than the iGEM one, the reason probably being the special functioning of the iGEM contest in which most of the tools needed (such as the plasmid vectors) are provided without any intellectual property rights. Outside of iGEM, of course, such tools are obviously not freely supplied, which may results in a patent experience if the materials used are under a proprietary license.
Nonetheless, these answers do not reveal what these past experiences are. To test our hypothesis (iGEMers acquire IP experience outside of iGEM because patented materials are not used) we got interested in the nature of iGEMers IP experiences.
The next answers are related to the current iGEM projects. The poll shows clearly that patents have been a problem for 10 % of the participants, which is not that much. But still : they do have been a concern in some cases. The relatively low number could be explained by the aforementioned reasons about the providing of non-patented tools by the iGEM organization.
It could also be explained by the redundant solutions offered by the living matter in general and the synthetic biology in particular. For instance, our team specifically picked a Dispersin gene that was not patented, though others were available (whose commercial use was protected).
Nevertheless to the question : "have other IP concerns (copyright, trademark) have negatively affected your current iGEM project ?" about 67% of the participants answered yes, which is considerably more, but as we have not even been concerned by such a problem, we find it hard to explain why this number is so high.
Our sole conclusion on this matter is that the IPR often does affect iGEM projects, even if in general the patents are not the limiting IP tool for them.
It is also surprising to note that 48% of the participants do not know whether their work is based on patented information or not, which shows a lack of information on their project material. Besides, it could stab them in the back if they were wishing to industrialize their ideas. Several questions were asked on the use of patented material. As it was discussed before, it is the most important IP issue in iGEM. Nonetheless, only 20% of the survey participants said that their team's project used patented material.
Furthermore, two thirds of the iGEM team members believe that using patented work would not stand in the way of patenting their own one. This is quite surprising because obviously one's research cannot be patented if based on protected materials. This statistic is very interesting as it shows how much most of the iGEM community's actors do not know their legal rights concerning the IP.
- Do you think BioBricks CAN be patented in your country ?
- And do you think they SHOULD be patentable ?
To the first question both opinions were equally represented. Nevertheless, it would have been interesting to know the country for each answer, even if the IP legislation is quite similar in most of the represented countries.
However, to the question "Should BioBricks be patentable ?", more than a half (56%) answered "no". This is probably linked to the fact that most iGEM competitors already use them without paying a license, so that they completely oppose such an idea. It also points out that most iGEM team members support the iGEM knowledge policy, which makes us believe that they would be inclined to acknowledge iGEM as a commons and would favorably respond to the changes resulting from the common reflexion we proposed at the end of the first part of this human practice study.
These inclinations are more or less equally represented in this poll, so that it does not reveal many things. The only really interesting point which has to be put forward is that most iGEM competitors who want to apply for IP protections do make some research on it, which emphasizes the complexity of such procedures and the lack of knowledge they probably had.
Our work with the University of British Colombia made us realize how often the intellectual property rights interfered with the different iGEM teams' project. Nonetheless, we were disconcerted when we found out the patents were not the main problem. Indeed, their source was copyrights and trademarks .
Besides, this survey deepened our main reflexion (q.v. part I) as it emphasized the problems due to the superimposition of the commons and the patent models. It also highlighted the global lack of knowledge of the iGEMers upon the intellectual property rights, which shows the necessity of informing about this particular topic. We sincerely hope we have helped to do so.
Part III: Scientific popularization
A lot of stereotypes and pieces of information circulate on sciences, so that we can sometimes find it hard to know where the truth is hidden. The public may sometimes look for a reliable source to make its own opinion. We are convinced that we have a role to play and have decided to involve ourselves in the researchers' night which is a european scientific popularization event.
More about the researchers'night
Since 7 years, this event is taking place on a single September night in about 300 cities all over Europe. During the Researcher's night, everyone can come and explore science in engaging ways. The main goal of this night is to put researchers in touch with public concern, and explain what researchers are doing, how, and why it is important for everybody's daily life.
This year, the theme is "Imagine the future": what future will emerge from research laboratories? How do the scientists imagine the future? Archeology, Physic, Phylososphy, Biosciences or Linguistic: researchers share their lab experiences and thoughts on the future.
For the first time, the Lyon-INSA iGEM team is taking part to this event. We will discuss how synthetic biology can help in the future, but also what the potential negative impacts of this new discipline are. We would like people not to think to corn only when they hear the word "GMOs". To do so we decided to focus on medical application of GMO's as insulin, growth hormone, artemisine,... We have to be opened to all possible questions and be prepared to face a very heterogeneous public.
This event will take place on Friday night, 28 september 2012 at CCO Villeurbanne. That is why this part is so short. The wiki is freezing in a few hours from and we will describe our adventures later if we get to go to Boston. If you want to read it we will be there!
Special thanks to our faculty advisor O. Brette for his advice and for his working late to help us and to the UBC team for sharing its poll results with ours.


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Ryan Hoxie
Future Ready Coach in Beaverton, Oregon
I believe the visionary leadership and focus of a school is defined by its staff. My foundation of visionary leadership is based on equity, innovation and community. More importantly, it is the responsibility of a school's leaders to truly believe that their vision is the best path for their school and community and to set a tone for implementing this vision into motion.


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At least seven of your online readers beg the E-R to write another editorial to address key points missing in your Monday editorial. We know we are in a horrible global war against terrorists. Osama bin Laden warns of new attacks. Our national security faces the challenge of identifying who are these terrorists, and security methods must be kept secret. Hence our agents remain silent under the barrage of the media and politicians. Our presidents have always had the authority and the obligation to protect us against enemies. A year and a half before Pearl Harbor, President Roosevelt ordered the interception of every communication that might be Axis spies or sympathizers.
Our 1978 Foreign Intelligence Surveillance Act (FISA) was tailored to the very slow moving Cold War with Russia. FISA lacks the speed and agility to handle the many terrorists groups who use today"s e-net. Our attorney general did approve Bush"s surveillance methods. A district judge ruled there was need to get warrants from a special court. But this is far too slow.
Our National Security Agency deserves kudos. Michael Hayden, its head, is a trusted professional, not a political voice. And for sure it is more than luck that we have had no terrorists attacks in the U.S. since 9/11.
Policy issues of protecting our country are assigned to our president. Don"t treat policy issues as legal issues. Americans must win this war, hence we must change FISA to meet today"s needs.
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I believe teaching and research should support each other as much as possible so that both students and instructors get something intellectually simulating. In that respect, I opted for teaching and designing classes that involve a significant research component. Currently, I am teaching two such classes at George Mason University.
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By: Angela Allison, This Delicious House
Stromboli Dough
- 4 cups all purpose flour plus more for rolling out the dough
- 1 envelope instant dry yeast (2 ¼ teaspoons)
- 2 teaspoons kosher salt
- 1 teaspoon sugar
- 1 ½ cups warm water (between 110° and 115°)
- 2 tablespoons olive oil plus more for greasing the bowl
Stromboli Filling
- 1 cup marinara sauce plus more for dipping
- 1 cup shredded mozzarella cheese
- 1 cup parmesan cheese plus more for sprinkling the top
- 1 tablespoon chopped basil plus more for sprinkling the top
- 24 slices salami (about ½ a pound)
- 1 large egg, beaten
Stromboli Dough
- To make the dough, combine the flour, yeast, salt, and sugar in the bowl of a stand up mixer fitted with hook attachment. Stir to just combine. With the mixer running on low, pour in the warm water and olive oil. Continue mixing the dough until all of the ingredients are incorporated and the dough forms a ball.
- Use about a teaspoon of olive oil to grease a large bowl. Place the dough ball in the bowl and cover with a clean dish towel. Place in a warm area and let rise for an hour.
- Once the dough has doubled in size, place it on a lightly floured surface and use a rolling pin or your hands to shape it into a 17 x 20 inch rectangle.
Stromboli Filling
- Preheat oven to 400 degrees. Line a large baking sheet with parchment paper and set aside.
- Spoon one cup of the marinara sauce over top of the dough, leaving about an inch border all around. Next, sprinkle on the mozzarella, one cup parmesan, and one tablespoon of diced basil. Layer on the salami.
- Use a pastry brush to brush the edges of the stromboli. Starting at the long end, carefully roll up dough cinnamon roll style. Place the stromboli on a large baking sheet lined with parchment paper. Brush on remaining egg wash and sprinkle with parmesan and basil if desired.
- Bake for 25 to 30 minutes, or until stromboli is light brown in color and cooked through. Let sit for five minutes before slicing with a serrated knife. Serve with marinara sauce for dipping.
This Stromboli can be made up to a day in advance. Just cover and refrigerate. When ready to bake, add about 2 – 3 minutes to the baking time. For more of Angela's recipes, click here.


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Wailing Wall
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Ok I really need help with this since I think I might have messed up things while trying to fix it.
Once I bought the PC I had problems certain games doing the "Display drivers have been recovered". It happened with Counter-strike and World of Warcraft and only those 2. The screen would flash and I would get that message. Trying work arounds I found here like unninstalling the default windows 10 update drivers and so on fixed the issue fox Counter-Strike Global offensive but things got a lot worse for other games that I didnt have this problem. Now I dont get the flashing screen and Driver recovered anymore. The screen just goes black and I get the No signal messagem from my display ( I use HDMI cables to plug). I can still hear the sound on the background but the only way to make the pc run again is a force shutdown.
Games that this happens now:
World of Warcraft : 10 minutes playing and I get the black screen ( previews driver stopped responding and has been recovered)
Blade and Soul : 1 hour or 2.
I've done a windows 10 reset and Installed nothing but those 2 games and the lastests drivers and I still get the black Screen.
Also I've tried old drivers and I did use the AMD clean Utility to test old drivers and new ones.
Basically I didnt have black screens, I would get the error message Driver stopped responding and has recovered but now I get the black screen and I dont know how to fix that ( since even a windows 10 reset didnt fix).
Here are my specs:
Windows 10 Pro
MotherBoard Gigabyte 970A-DS3P
Bios version - F1
CPU - AMD fx-8320
Memories Slot 1 - 4GB DDR3 SDRAM PC3- 12000 / Golden Empire CL9-9-9 DDR3 - 1333 XMP : 1.5V , Clk: 750.0MHZ
Slot 2 - 4GB DDR3 SDRAM PC3 - 12800 / Golden Empire CL11-11-11 D3-1600 XMP: 1.5V , Clk: 800.0MHZ
SSD 120 GB KingSton SV300S37A120G ATA device
HDD 500GB WDC WD5000AAKX-00U6AA0 ATA Device
GPU AMD Randeon R9 285/380 Memory 2048 MB
Video Bios : 113-285A- CDFX-W83-106
Driver Version 15.300.1025.1001
Temperatures while playing BnS Full graphics
Hope you guys can help me , I've been suffering from this for the past 2 months since I tried to fix and made things worse.