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Eleven laboratories evaluated the use of dried blood and plasma spots for quantitation of human immunodeficiency virus (HIV) RNA by two commercially available RNA assays, the Roche Amplicor HIV-1 Monitor and the bioMerieux NucliSens HIV-1 QT assays. The recovery of HIV RNA was linear over a dynamic range extending from 4,000 to 500,000 HIV type 1 RNA copies/ml. The Monitor assay appeared to have a broader dynamic range and seemed more sensitive at lower concentrations. However, the NucliSens assay gave more consistent results and could be performed without modification of the kit. HIV RNA was stable in dried whole blood or plasma stored at room temperature or at −70°C for up to 1 year. Dried blood and dried plasma spots can be used as an easy and inexpensive means for the collection and storage of specimens under field conditions for the diagnosis of HIV infection and the monitoring of antiretroviral therapy.
Human immunodeficiency virus (HIV) RNA levels in blood plasma are used to monitor the response to antiretroviral drug therapy in developed countries. Since the International AIDS Conference held in Durban, South Africa, in 2000, there has been a global effort to provide access to antiretroviral drugs to all infected individuals, including those in the resource-poor countries which have been hit the hardest by the AIDS pandemic. Studies have demonstrated that the provision of treatment is not enough, however. In order for the drugs to be most effective, both for an individual and for public health reasons, it will be necessary to monitor the responses to the therapy. HIV RNA assays typically use plasma, which implies access to laboratory equipment that may not be readily available in all field settings. Therefore, alternative specimens must be considered for use in these situations.
Whole blood dried on filter paper (dried blood spots [DBSs]) has been used to qualitatively detect HIV antibodies (13, 15), HIV DNA (1, 3, 5-7, 9, 10, 11, 12, 16, 18) and HIV RNA (4, 14, 17; J. L. Gerstel and A. M. Comeau, Proc. 10th Natl. Neonatal Screening Symp., abstr. P-19, p. 64, 1994). In addition, dried plasma spots (DPSs) have also been used to quantitate the HIV load (8). Although the stabilities of antibodies and DNA in DBSs have been determined (2, 6, 13), there has been some question regarding the stability of the HIV RNA when it is dried and stored at room temperature (14, 17).
The purpose of this study was to compare two different methods for quantitatively measuring HIV RNA in DBSs and DPSs and to assess their long-term stability at room temperature and at −70C.
(This study was presented in part at the 12th World AIDS Conference, Geneva, Switzerland, 28 June to 3 July 1998 [S. Cassol, A. Comeau, S. Fiscus, G. Aldrovandi, J. Sullivan, J. Bremer, and B. Jackson, Abstr. 12th World AIDS Conf., abstr. 33166, 1998].)
Specimens.Three different panels were prepared by the Virus Quality Assurance Laboratory by using filter paper (903; Schleicher & Schuell, Keene, N.H.) spotted with 50 μl of plasma or whole blood. The 903 filter paper is inexpensive, available worldwide, and commonly used for assays for the screening of newborns (Guthrie cards) and has been used before for the detection of HIV antibodies (2, 15), DNA (5-7, 9-12), and RNA (8, 14, 17). The spotted filter papers were allowed to dry overnight at room temperature, placed in individual ziplock bags containing a silica desiccant (MultiSorb Technology, Inc., Buffalo, N.Y.), and then frozen at −30 or −70°C or stored at room temperature. Panels 1A and 2 were frozen at −30°C; panel 1B consisted of spots from panel 1A which were subsequently thawed and stored at room temperature for 3 months prior to retesting; panel 3 was stored at either −70°C or room temperature, with no freeze-thaw events, for various lengths of time up to 52 weeks. All specimens were coded to blind the laboratories.
Panel 1 consisted of seronegative plasma and whole blood, to which fivefold serial dilutions of a well-characterized HIV type 1 (HIV-1) stock with from 0 to 500,000 copies/ml was added (nominal concentrations). Each specimen was tested in duplicate by the participating laboratories, and each panel was tested at two different time points (panels 1A and 1B).
Panels 2 and 3 each consisted of liquid plasma, DPSs, and DBSs from three HIV-1-infected patients and one uninfected patient, all in triplicate. For the six HIV-1-infected patients (three different patients for each of the two panels), the nominal concentrations determined by the Virus Quality Assurance Laboratory by the Roche Diagnostics (Branchburg, N.J.) Amplicor HIV-1 Monitor assay with liquid plasma were as follows: for panel 2, 1,157, 16,620, and 231,040 copies/ml, respectively; for panel 3, 1,064, 99,980, and 65,332 copies/ml, respectively.
Panel 3 was designed to evaluate the stability of HIV RNA in DBSs and DPSs during storage at room temperature and −70°C. Each panel consisted of triplicate blood or plasma spots from four HIV-infected patients (12 spots for each panel). One complete set (blood and plasma) was assayed at baseline. Four sets (samples B and D) were placed in storage at room temperature, and the other four sets (samples C and E) were stored at −70°C. One set of blood and plasma spots from each storage condition was assayed after 2, 4, 26, and 52 weeks of storage.
HIV-1 RNA assays.Assays for detection of HIV-1 RNA were conducted over a 3-year period (September 1997 to June 2000), and multiple kit lots were used. Three (panels 1A, 1B, and 2) or four (panel 3) laboratories used the NucliSens HIV-1 QT assay (bioMérieux, Inc. [formerly Organon Teknika], Durham, N.C.) with minor modifications. One DPS or DPS was placed in 9 ml of NucliSens lysis buffer and rocked at room temperature for 2 h to elute the RNA from the filter paper. Once the filter paper was removed, the manufacturer's instructions were followed for the remainder of the procedure.
Five (panels 1A and 1B) or six (panel 2) laboratories used a modified Amplicor HIV-1 Monitor assay (version 1.0; Roche Diagnostics) to quantitate the RNA in the blood and plasma spots. HIV RNA was eluted from the filter paper by treatment with a chaotrope, organic reagent, and detergent (CORD) solution consisting of 33% (vol/vol) buffered phenol (pH 4.3), 1.34 M guanidinium isothiocyanate, 0.2% (vol/vol) Sarkosyl, 0.3% (vol/vol) sodium dodecyl sulfate, 0.2% (vol/vol) mercaptoethanol, 0.6% (wt/vol) glycogen, and 8 mM sodium citrate. The DBS or DPS was cut or punched into small pieces and incubated in 0.75 ml of CORD reagent containing 0.5 μg of tRNA and 3.3 μl of the kit quantitation standard at 56°C, with shaking, for 30 min. The RNA was then extracted from the mixture with chloroform, followed by alcohol precipitation and elution with the HIV-1 Monitor specimen diluent (100 μl). Amplification and detection of the extracted RNA (50 μl) were performed according to the manufacturer's guidelines. The CORD reagent was prepared by Roche Molecular Systems and distributed to the laboratories that used the HIV-1 Monitor assay.
Statistical methods.Data from the three panels were transformed to base 10 logarithms for analysis. The data for the HIV-negative specimens were excluded from all of the analyses. Data from the NucliSens and Monitor assays were analyzed separately. Linear regressions of the log10 estimated HIV RNA concentration on the log10 nominal HIV RNA concentration were used to analyze the data for panels 1A and 1B. The analysis was restricted to six laboratories from which results were obtained for both rounds of testing (Monitor assay, four laboratories; NucliSens assay, two laboratories). Predictor variables were added to the model to test for variations in the results between DBSs and DPSs, between the two panels, or among laboratories. More complex predictors were added to determine if differences between panels or between specimen types varied over laboratories or if any of the differences varied with nominal concentration.
Analysis of variance was used for panel 2. Indicator variables for the donor were included in all models. Hematocrit-corrected estimates of the concentrations from DBSs with those from DPSs were compared with estimates of the concentrations from plasma in separate analyses. Predictors were added to the models to determine if differences between specimen types varied among donors or laboratories.
The stability of HIV RNA in stored DBSs and DPSs was assessed by using regressions on the log10 estimated RNA concentration on time in storage and donor to model the results for panel 3. The analysis was stratified by specimen type (DPSs versus DBSs) and storage condition (room temperature versus −70°C) to form four separate regressions. Variables were added to the models to determine if the rate of change in HIV RNA concentration in storage varied among donors or laboratories.
In some cases, results that were below the limit of detection of an assay were included in an analysis. Estimates that were below the limit of detection for the NucliSens kit were set at 400 copies/ml. Estimates that were below the limit of detection for the Monitor test were set at values that were calculated by substituting an optical density of 0.2 units for the optical density for the undiluted amplified sample. This is the minimum RNA concentration that would have produced a positive result by the Monitor test, given the results for the internal quantitation standard in each assay.
Panels 1A and 1B were used to evaluate the technical performance of the laboratories, focusing primarily on their abilities to perform the DBS and DPS extractions and the quantitative RNA assays. One false-positive result was obtained by the NucliSens assay (estimated RNA concentration, 420 copies/ml). Another was obtained by the Monitor assay (estimated RNA concentration, 285 copies/ml).
The samples with nominal concentrations of 800 copies/ml were excluded from the statistical comparisons of estimates of the concentrations from DBSs and DPSs because nearly half of the results were below the limits of detection of the two kits (NucliSens assay, 8 of 12 from DPSs and 7 of 12 from DBSs; Monitor assay, 9 of 19 from DPSs and 7 of 21 from DBSs). Results at a nominal concentration of 4,000 copies/ml that were below the limit of detection of the assay were included in the analysis, as described earlier (Nuclisens assay, 4 of 12 from DPSs and 2 of 12 from DBSs; Monitor assay, 1 of 22 from DPSs and 3 of 21 from DBSs).
Log-log plots of the estimated HIV RNA concentrations from DBSs against the nominal RNA concentrations are shown separately for the NucliSens assay (Fig. 1A) and the Monitor assay (Fig. 1B). On average, estimates by the NucliSens assay for panel 1A were 0.11 log10 (29%) higher than estimates for panel 1B (P = 0.011), and the results from DBSs were, on average, 0.11 log10 (29%) higher than those from DPSs. There was no evidence that the differences between log-transformed estimates of the concentrations from the two panels or two specimen types varied among nominal concentrations or among laboratories.
The results of the Monitor assay were more heterogeneous than those of the NucliSens assay, which made the analysis very difficult. The difference between estimates of the concentrations from DBSs and DPSs depended on both the laboratory and the panel that was considered (P = 0.016). When the results for DPSs and DBSs were analyzed separately, estimates of the concentrations from DPSs in panel 1A were, on average, 0.27 log10 (86%) higher than those from DPSs in panel 1B (P < 0.001), with no evidence that the difference between panels varied among laboratories or nominal concentrations. However, for DBSs, the differences between panels varied among laboratories (P < 0.001) and nominal concentrations (P = 0.005), making it very difficult to draw any general conclusions from the data.
Log-log plots of median hematocrit-adjusted estimated HIV RNA concentrations from DBSs in panel 2, for each donor in each laboratory, against the median for plasma, for data combined across laboratories, are shown separately for the NucliSens assay (Fig. 2A) and the Monitor assay (Fig. 2B). By the NucliSens assay, the hematocrit-corrected estimates of the concentrations from DBSs were, on average, 0.078 log10 (16.5%) lower than those from plasma (P = 0.16), with no detectable variation in the difference among laboratories (P = 0.39) or donors (P = 0.49). Similar results for panel 2 were seen for the comparison of DPSs and plasma by the NucliSens assay (data not shown).
Differences between estimates of the concentrations from DBSs and plasma by the modified Monitor assay varied among the six laboratories (P < 0.001). No differences between the two sample types were noted in two laboratories (P = 0.24 and P = 0.17), but estimates of the concentrations from DBSs were, on average, 0.22 log10 (40%) lower than those from plasma in a third laboratory (P = 0.04). In each of the other three laboratories, the difference between DBSs and plasma varied among donors. The differences (concentrations in DBS − concentrations in plasma) ranged from −0.44 to 0.82 log10 across donors and laboratories, even though the specimens from the three donors were assayed in the same run in each laboratory. For the Monitor assay, the difference between estimates of the concentrations from DPSs and plasma varied among laboratories (P = 0.002) but not among donors (P = 0.20) (data not shown).
Panel 3 was designed to evaluate the effects of long-term storage on RNA levels in DBSs and DPSs (Fig. 3) and was tested only by the NucliSens assay. Data through 52 weeks of storage were obtained from three laboratories, and data through 26 weeks of storage were obtained from a fourth laboratory. The results for one of three HIV-infected donors were excluded because 40% of the values were below the limit of detection of the assay. Values below the limit of detection were obtained for DBSs and DPSs stored at both temperatures and for DBSs and DPSs at all time points for this donor.
Rates of change in the log10 RNA concentration varied among the laboratories for DBSs stored at both room temperature (P < 0.01) and −70°C (P < 0.001) and for DPSs stored at −70°C (P < 0.001), but there was little or no evidence of substantial loss of RNA from these samples in any of the laboratories. The rates of change in the RNA concentration differed from zero for only 5 of 12 samples (P < 0.02 for each versus P > 0.10 for changes that were not statistically significant). These occurred at −70°C at four laboratories and at ambient temperature at only one laboratory. The changes were actually positive at four of the five laboratories. The one statistically significant negative change indicated a 52-week loss of only 7% at −70°C. No variation in the rate of change in RNA concentration in DPSs at room temperature was detected among the laboratories. The 52-week loss averaged 2.4%, but this was not statistically significant (P = 0.18).
Both the NucliSens assay and a modified version of the Monitor assay can be used to quantitate HIV-1 RNA from DBSs or DPSs, although in this evaluation there was considerably less variation with the NucliSens assay. Detection of HIV RNA was linear over a dynamic range extending from 4,000 to 500,000 HIV-1 RNA copies/ml.
Variation in the Monitor assay made analysis difficult, and the sources of this variation were difficult to pinpoint. The variability might be due to the modified RNA extraction method that had to be used for the dried spots. Phenol-chloroform extractions are more technically demanding, and differences in the recovery of the appropriate phase during the extraction may affect HIV RNA recovery. Potential sources of variation include the retention of various levels of inhibitors such as heme and iron, errors during the RNA extraction, and reagent or kit variability. Furthermore, the reagents used for the modified Monitor extraction method were in their initial stages of development and, hence, were not completely optimized. To the best of our knowledge, Roche no longer supports this application and these reagents are not available commercially.
On the other hand, the Monitor assay appeared to be somewhat more sensitive, particularly in detecting specimens with lower viral loads. This is probably a function of the differences in the amount of the actual RNA eluate that went into the amplification steps for the two assays. For the Monitor assay, the RNA was eluted in 100 μl of diluent and half was used for amplification. The specimen input for the plasma spot was equivalent to 25 μl, a volume comparable to that used for the standard Monitor assay. The NucliSens assay elutes the RNA into 50 μl of diluent, but only 5 μl is used for amplification. The specimen input for the plasma spot was equivalent to 5 μl, which is 1/4 to 1/20 the volume used for plasma analysis by the NucliSens assay. The NucliSens assay could potentially be made more sensitive by reducing the elution volume used during the extraction.
HIV RNA was stable in DBSs and DPSs stored at room temperature and at −70°C for at least 1 year (Fig. 3), and possibly longer. The differences observed in our experiments were probably due to factors such as interassay variation and/or lot-to-lot variation in the kits and are not considered to be clinically significant. Interassay variation would account for the small positive changes if results in a given laboratory were unusually low at early time points or unusually high at later time points, as was the case in some laboratories. These data confirm those of O'Shea et al. (17) regarding the stability of HIV RNA dried on Guthrie cards. Previous results suggesting that HIV RNA was lost with increasing time of storage (14) was probably due to differences in the paper used.
Although the sensitivity of an RNA assay with DBSs may never reach the sensitivity of an assay with whole plasma, it may still be sensitive enough given recent changes in treatment guidelines (patients should be treated when viral load is >50,000 copies/ml or when the CD4 count is <350 cells/mm3). In this study we were able to reliably measure viral loads of 4,000 copies/ml or greater. The potential to improve this sensitivity exists and may be warranted. DBSs offer an easy and inexpensive means for the collection and storage of blood, since they are stable and noninfectious and can easily be sent to centralized testing laboratories for analysis. DBSs clearly provide the perfect means for the collection of specimens under field conditions for the diagnosis of HIV infection and the monitoring of antiretroviral therapy and vaccine efficacy.
This work was supported by the Pediatric AIDS Clinical Trials Group through the following grants and contracts or source: AI35712 and AI85354 (to D.B., C.J., and J.B.), AI32907 (to J.L.S.), CFAR grant AI42845 (to J.L.S.), HD-05-3328 (to A.M.C.), 97PVCL05 (to G.A.), 97PVCL06 (to S.A.F.), 97PVCL07 (to J.B.J.), and the Ontario Ministry of Health (to S.A.C.). BioMerieux and Roche Molecular Systems provided the kits for the assays.
We thank Kevin Byron, Don Decker, Jim Ellerbrock, Jacalyn Gerstel-Thompson, Michelle Janes, Richard Pilon, Jana Parsons, Jody Schock, Sal Scianna, and Art Sunhachawee for expert technical assistance and Suzanne Granger for statistical and graphic expertise.
- Received 3 July 2002.
- Returned for modification 20 September 2002.
- Accepted 29 January 2003.
- Copyright © 2003 American Society for Microbiology


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Here are some empties. The ones on top are WW factory 180 gr. loads. They chronoed between 2300 and 2400 fps. You can see some primer flattening there.
Below are some empty elk loads. They were 43.5 gr of AA 4350 behind a 200 Hornady RN. Primers were CCI and Remington. They chrono-ed around or below 2,000 fps. I've gone up to 42 H4350, but where we hunt 65 yards is a long shot.
I'm not convinced about the accuracy of my brother's cheap Chrono, but it detects a 10-20 fps variability in my black powder loads.

subset: commoncrawl


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Optimizing Usage Using Zone Entry Data
Last week, the wonderful Jess Schmidt (@2_for_slashing) published the first 20 games worth of zone entry data for the 2014-15 season. Over the past couple years, it has become common knowledge that a carry-in zone entry produces over twice as many shot attempts as a dump-in. As a result, many teams (probably including the Flyers) have started paying closer attention to zone entry data.
Zone entry data can be useful to executives, coaches, and even players. For a coach who is looking to optimize his deployment, this data can prove to be extremely valuable. In terms of the Flyers, Craig Berube has made some good decisions when it comes to getting the most out of his lineup's zone entry and entry prevention ability. There are also a few changes that could be made to improve the overall efficiency of the team.
Now obviously a coach should not make usage decisions based entirely on zone entry data, especially after just 20 games. Matchups and offensive ability often play a large part in determining how a player is utilized. This data is just another weapon that a coach should have in his arsenal when making these decisions during games.
Let's take a look at some changes that could be made. For reference, here is the entry data for the first 20 games.
It's no secret that Braydon Coburn is the most successful Flyers defensemen when it comes to breaking up attempted zone entries against. He leads the Flyers in that category this season and he has led them in the past as well. After 24 games this season, he has started in the offensive zone less than any other defenseman (27.0%), and is near the top (34.4%) when it comes to DZSt%. When Coburn starts his shift in the defensive zone, he isn't able to use his talents to prevent the puck from getting there.
With very few reliable defensemen on this roster, Berube is in a difficult position. Taking defensive zone starts away from Coburn means that they are going to guys like Nicklas Grossmann and Andrew MacDonald. With that said, giving Coburn more opportunities to use one of his greatest skills might improve the overall efficiency of the team.
It's well documented that Andrew MacDonald is the worst defenseman on the Flyers roster when it comes to preventing successful entries against. During the first 10 games of his 2014-15 season, he broke up one (1) entry out of 55 attempts. I'm no expert myself, but that seems rather, um, bad.
MacDonald has started 32.4% of his shifts in the offensive zone this season while starting 33.% of them in the defensive zone. His predicament is the exact opposite of Coburn's. MacDonald should start in the defensive zone more often in order to limit the number of times that he tries to defend the blue line.
MacDonald is (how do I put this nicely?) not necessarily 'good' at anything. If theres one thing he excels at, however, it is playing defense once the puck is already in the defensive zone. With that established, it certainly makes more sense to give him a few more defensive zone starts. I think I've made it very clear how I feel about the MacDonald contract. The Flyers can still make the best of a bad situation by optimizing the skills that he does have.
Jakub Voracek has been the Flyers most successful forward in terms of gaining the blue line with control. He has failed on just 5% of his entries, and he controls the puck 62.8% of the time. He led the Flyers in control % for 2013-14 as well. He is also one of the top Flyers this season when it comes to successfully exiting the defensive zone.
After 36 games, he has started more shifts in the offensive zone (39.9%) than any other Flyer. It isn't difficult to understand why; He is beginning to emerge as one of the top offensive threats in the league.
I still think that it would benefit the Flyers to start him outside of the offensive zone more often. Giving Voracek just a few more neutral and defensive zone starts would put him in a position to use his entire skill set more often, while at the same time not necessarily limiting his offensive role. These offensive zone starts could be given to players who have more difficulty gaining the blue line, while the more capable Voracek could use his exit/entry talents to move the puck the full length of the ice.
Like I stated earlier, no drastic decisions should be made on the basis of zone entries alone, especially after just 20 games worth of data. There are no changes in usage that will turn the Flyers into a positive possession team with this roster. As the season goes on and the sample size gets larger, hopefully the Flyers will begin to look at things analytically and explore different ways that they can use this data to improve their possession game as a team.
Data from this article was obtained from Jess Schmidt (@2_for_slashing) and stats.hockeyanalysis.com


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Article content
LONDON — Fund manager Glennmont Partners said on Monday it had established a joint venture with PGGM Infrastructure Fund to manage a portfolio of Italian renewable energy assets.
The new company, called Green Energy Management Services, will develop, build and operate large portfolios of clean energy assets across Italy.
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Glennmont Partners, PGGM fund form Italian renewables venture Back to video
It will begin operations with around 400 megawatts of wind assets under its management, making it one of the biggest asset management operators in the Italian market with immediate effect, Glennmont Partners said.
Glennmont Partners focuses on investment in clean energy infrastructure and has around 2 billion euros ($2.2 billion) of assets under management.
PGGM Infrastructure Fund is part of Dutch pension group PGGM.
($1 = 0.8913 euros) (Reporting by Nina Chestney; Editing by Mark Potter)


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Company: Botanical Bakery, LLC, Fairfield, Calif.
Web site: www.botanicalbakery.com
Introduced: November 2008
Distribution: National
Suggested Retail: $1.75 to $2.25 for a 1-oz. two-pack; $14 to $19 for a 6.5-oz. carton
Product Snapshot: Instead of spending boo-koo bucks for a refreshing day at the spa, consumers can now bite into a botanical-infused tea cookie, handcrafted from the finest of organic ingredients and available in such offerings as Lavender Tea, Cinnamon Basil and Cardamom. In January, the Lemon Thyme variety was brought to the marketplace.
Ingredients (Cinnamon Basil): Organic unbleached flour, organic sweet cream butter, organic pure cane sugar, organic basil, organic cinnamon vitamin E (an antioxidant).


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The Story – Gotham City Garage #20 (2018)
Gotham City Garage #20 (2018) : What secrets await in the dark caves of Ra's al Ghul?
Free DC Comics Download
Gotham City Garage #20 (2018)
Language : English | Year : 2018 | Size : 17 MB
Notes :
- If you have any difficulties to download the files, please refer to this how-to download page.
- All of the comic files are packed on .CBR and/or .CBZ file formats. Here are some of the reader apps that i can recommend : YAC Reader (Win, OSX, Linux, iOS), ComicRack (Win, Android, iOS), CDisplayEx.
- To extract any compressed files, I recommend using 7-Zip.
- If you encounter any broken links or corrupt files, please write on the comment section or message me through the contact form.
- Want to see all the comic list? Please go to this page.


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Honda has become the first automaker to kick off an extended shutdown of its US manufacturing operations in response to the novel coronavirus pandemic. The company announced on Wednesday morning that it's closing all of its automotive production plants in North America for six days due to an "anticipated" drop in demand.
In addition, Fiat Chrysler is indefinitely closing one of its factories where the Ram 1500 is made after a worker tested positive for COVID-19, the disease caused by the novel coronavirus.
Honda says it will pay all 27,000 workers across the closed facilities during the shutdown. The six-day shutdown will drop the company's North American vehicle output by about 40,000 vehicles. (The company made nearly 2 million vehicles in North America in 2019.)
Automakers in the US have faced increased pressure over the last few days to shut down their factories as the country comes to grips with the pandemic, and after the federal, state, and local governments started recommending people stay in their homes as much as possible. The United Auto Workers even advocated for a two-week shutdown of Ford, General Motors, and Fiat Chrysler factories, though the companies and the union ultimately agreed on Tuesday evening to just scale back and space out shifts at those automakers' plants.


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Software Defined Infrastructure Market
Market Research Future (MRFR) confirms that the software defined infrastructure market 2020 can possibly touch USD 95 billion by 2023-end. The market is also estimated to advance at a rate of 22% over the forecast period (between 2017 and 2023), despite the COVID-19 impact. We will provide COVID-19 impact analysis with the report, offering detailed market developments following the coronavirus disease outbreak.
FREE PDF@ https://www.marketresearchfuture.com/sample_request/5702
Top Drivers and Key Restraints
Considering the long term ramifications of the COVID-19 outbreak, a large number of companies in the technology industry have had to deal with numerous challenges. Many had to close down their factories or restrict business traveling. Major events such as Google I/O, Facebook's F8, the Mobile World Congress and the Geneva Motor Show had to be called off owing to the lockdown following the pandemic. Employees had to adopt the work from home practice to prevent the spread of SARS-CoV-2. But to overcome the issues induced by the novel coronavirus, companies are now more focused on return on investment/RoI, business continuity schemes and operational resiliency. This situation has led to a higher demand for a strong software defined infrastructure, as it helps smoother functioning with automation of the processes and the prevention of manual tasks along with facilitation of rule-based servers.
But the post-pandemic era has also seen a growth in the spending on cloud adoption as well as remote work enablement. This has resulted in heightened demand for content workflow and management applications, application platforms, collaborative applications, system and service management software, security software and more, which benefits the market. Also, the soaring demand for better organized IT infrastructure, higher use of data centers, growing consumption of cloud computing, and lower capital expenditures has been favorable for the software defined infrastructure market.
The rising deployment of artificial intelligence as well as hybrid cloud services and their growing integration with the current infrastructure can also induce considerable market growth. Several leading contenders are busy innovating and are steering the organizations' focus towards software defined infrastructure.
For instance, in July 2020, Nutanix, a renowned enterprise cloud computing provider, teamed up with Birmingham City Council's Information, Technology and Digital Service/IT&D to shift its operations to a hybrid cloud software infrastructure.
Market Segmentation
The global software defined infrastructure market has been segmented on the basis of solution, services, vertical, and region. Solutions have been segmented into software-defined storage (SDS), software-defined networking (SDN), software-defined computing (SDC), and others.
Services have been segmented into consulting services, managed services, integration, and deployment services.
Verticals, where SDI is adopted, include retail, telecom, manufacturing, healthcare, transportation, defense, government, and others.
Regions covered in MRFR's report include Asia Pacific, North America, Europe, and the Rest of the World.
Regional Insight
The global software defined infrastructure market is studied for North America, Europe, Asia Pacific, and Rest of the World.
North America is at present the worldwide leader in the software defined infrastructure market, followed by Europe. The market attractiveness in the region has been the result of the widespread pool of leading contenders present in the United States along with the rising use of data centers. The market also stands to profit from the continuous innovations in virtualization and cloud technologies combined with the surging deployment of integrated approach and automation in business processes.
With the fastest growth rate, the APAC market is anticipated to soar significantly backed by the consistent economic growth in India, Taiwan and China. The escalating uptake of server virtualization platforms and the growing adoption of Software Defined Networking (SDN) and Network Function Virtualization (NFV) across Japan also enhance the market size here. With the growth in the 5G technology along with its applications in retail, healthcare, and others, the regional market will receive a further boost in the following years.
Top Market Firms
The top market firms identified in the report are IBM Corporation (U.S.), Fujitsu, Ltd.(Japan), Dell Inc. (U.S.), VMware Inc. (U.S.), Hewlett Packard Enterprise Co. (U.S.), Oracle Corporation (U.S.), NEC Corporation (Japan), Citrix Systems, Inc. (U.S.), Microsoft Corporation (U.S.), Hitachi, Ltd.(Japan), Cisco Systems, Inc. (U.S.), and more.
Some of the prominent innovators that are actively seeking a better position in the SDI market include Pica8, Inc.(U.S.), Wipro Limited (India), Plexxi (U.S.), Nexenta Systems, Inc. (U.S.), Arista Networks (U.S.), Brocade Communications Systems, Inc. (U.S.), Intel Corporation (U.S.), Amazon Web Services (U.S.), PLUMgrid Inc (U.S.), Nokia (Finland), Red Hat, Inc. (U.S.), Radware Corporation (Israel), Savvis (U.S.), Juniper Networks (U.S.), to name a few.
"Don't miss out on business opportunities in Software Defined Infrastructure Market. Get detailed report and gain crucial industry insights that will help your business grow."
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Cloud Network Infrastructure Market Research Report – Forecast to 2023
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Tag: navratri days
Updated : Sep 16, 2020 in Latest news updates
Navratri shakti || Facts You need to know about Navratri festival
Navratri shakti Navratri shakti which means "nine nights" has celebrated to honor Mother Durga. Throughout this period, Goddess Durga is worshiped in all her divine forms including Goddess Durga, Goddess Kali, Goddess Saraswati, and Goddess Lakshmi. It has one of…


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Opened 5 years ago
Closed 5 years ago
#16359 closed enhancement (implemented)
Add new ed25519-related lines to sanitized bridge descriptors
|Reported by:
|Owned by:
|nickm, isis, atagar
|Actual Points:
|Parent ID:
Recent Tor bridges include ed25519-related lines in their server descriptors and extra-info descriptors. We need to sanitize them in a way that doesn't leak the new ed25519 bridge identity. See also some discussion about this on tor-dev@.
I just finished writing some possible sanitizing code for this and would appreciate a quick review of the new parsing code there.
Also, here are two sanitized bridge descriptors as samples:
@type bridge-server-descriptor 1.1 router hatak2 10.131.136.200 89 0 0 or-address [fd9f:2e19:3bcf::d4:b0b5]:89 master-key-ed25519 vtKSwo5ic01Lmd1bkRZ64Pn+3p6463SWo59mUobgw1w platform Tor 0.2.7.1-alpha-dev on Linux protocols Link 1 2 Circuit 1 published 2015-06-12 07:32:33 fingerprint FEC3 88B2 464F 8A84 AF02 CB76 3B10 7F71 2750 B3A9 uptime 208681 bandwidth 14971520 104857600 153167 extra-info-digest 64ED1D6F4851BEC31A1FB0F98BBA18F5ADAD6041 KCnzQ4dTAV+KqwyFYPOlJ9UwYW0vE3wzanHmQ0C1SnI hidden-service-dir contact somebody ntor-onion-key 7aW+CYWazyD6+g4oZTLZ5UgjashXriSyuCrc9MnwYEA= reject *:* router-digest-sha256 4TfyBALOAWmuLv3Ag5JvLsrXwraNsfxswCnGvVkbPQA router-digest C3140734BF6DEC26895456427D793E2ED8BC6F4B
@type bridge-extra-info 1.3 extra-info hatak2 FEC388B2464F8A84AF02CB763B107F712750B3A9 master-key-ed25519 vtKSwo5ic01Lmd1bkRZ64Pn+3p6463SWo59mUobgw1w published 2015-06-12 07:32:33 write-history 2015-06-12 06:25:25 (14400 s) 412672,518144,427008,678912,39168000,422912 read-history 2015-06-12 06:25:25 (14400 s) 4737024,6061056,4524032,5554176,42741760,4158464 dirreq-write-history 2015-06-11 21:30:09 (14400 s) 31744,0,0,0,0,0 dirreq-read-history 2015-06-11 21:30:09 (14400 s) 5120,0,0,0,0,0 geoip-db-digest 0A1F9C09E08F6F2490E8880664D4E863D1680A12 geoip6-db-digest A6E9B5DE6F887315749B29F9C9F698215BE5240A dirreq-stats-end 2015-06-11 21:30:16 (86400 s) dirreq-v3-ips dirreq-v3-reqs dirreq-v3-resp ok=0,not-enough-sigs=0,unavailable=0,not-found=0,not-modified=0,busy=0 dirreq-v3-direct-dl complete=0,timeout=0,running=0 dirreq-v3-tunneled-dl complete=0,timeout=0,running=0 transport fte transport obfs4 transport websocket bridge-stats-end 2015-06-11 21:34:31 (86400 s) bridge-ips bridge-ip-versions v4=0,v6=0 bridge-ip-transports router-digest-sha256 KCnzQ4dTAV+KqwyFYPOlJ9UwYW0vE3wzanHmQ0C1SnI router-digest 64ED1D6F4851BEC31A1FB0F98BBA18F5ADAD6041
New/updated lines are:
@typelines contain updated minor version numbers because of additional lines.
master-key-ed25519in both server descriptors and extra-info descriptors, containing SHA256 digests of keys. Note that extra-info descriptors produced by Tor don't (yet) contain such lines.
extra-info-digestin server descriptors now contains two digests matching the digests in the
router-digest-sha256lines in extra-info descriptors.
router-digest-sha256contains the SHA256 of SHA256 of full descriptor contents including signatures.
Anything else I'm missing?
Child Tickets
Change History (1)
comment:1 Changed 5 years ago by
|→ implemented
|new → closed
This code is now running and producing sanitized bridge descriptors for https://collector.torproject.org/. Hopefully it doesn't break anything. Closing.


text:
Change is inevitable. Resisting change can be a disaster to progress in life and business. Learning to adopt and embrace change to our advantage is an essential skill for everyone in an organisation.
Program Content
- The nature of change and its impact on our personal and professional lives
- The neuroscience of how our brain responds to change
- Understanding why we resist change
- Accepting the realities of change
- Dealing with individual and organisational responses to change
- Succeeding amidst change at work & in life


text:
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Coming Soon!
It is time for you to stand out in your remote office. Out of sight does not need to mean that you are out of mind. In this book we help you create the habits needed to showcase your talent while also taking care of yourself. Whether you are working for yourself or someone else, this practical guide will help you craft the right schedule and set the boundaries needed to shine from afar.


text:
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South Padre Island is known primarily as a Spring Break destination. However, it is truly a beach for all seasons. … Read Article
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Scottish Daily News – Wikipedia, The Free Encyclopedia
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text:
How many syllables are in enhance? 2 syllables
Divide enhance into syllables: en-hance
Definition of: Enhance (New window will open)
How to pronounce enhance:
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Are you a freelance writer, novelist, or short story writer? If so, join our writing community with cash prize contests, freelance opportunities, and free writing tools.
Enhance Poems: (See poems with this word. New window will open)
enhances (2 syllables),
heighten (2 Syllables), raise (1 Syllables)
accelerate (4 syllables), adorn (2 syllables), amend (2 syllables), augment (2 syllables), civilize (3 syllables), deepen (2 syllables), dignify (3 syllables), edify (3 syllables), educate (3 syllables), elevate (3 syllables), embellish (3 syllables), emend (2 syllables), endow (2 syllables), maximize (3 syllables), raise (1 syllables),
anse, chance, crance, dance, france, glance, hance, lance, mance, nance, prance, rance, schanz, schranz, stance, trance, vance
advance, askance, duran's, enhance, expanse, finance, lafrance, mccance, romance
pomerance, pomeranz, refinance
What do you think of our answer to how many syllables are in enhance? Are the syllable count, pronunciation, words that rhyme, and syllable divisions for enhance correct? There are numerous syllabic anomalies found within the U.S. English language. Can enhance be pronounced differently? Did we divide the syllables correctly? Do regional variations in the pronunciation of enhance effect the syllable count? Has language changed? Provide your comments or thoughts on the syllable count for enhance below.
A comprehensive resource for finding syllables in enhance, how many syllables are in enhance, words that rhyme with enhance, how to divide enhance into syllables, how to pronounce enhance, how to break enhance into syllables, and how to pronounce enhance.


text:
Thanks so much for submitting a report. It has been emailed to the Rum Captain and will be actioned shortly.
Have you found an online vendor selling XM ?
Please input the URL directly to the vendor page with the rum for sale and we will automatically show it on RumRatings
Thank-you for your submission. It will appear on the site once verified.
(3 ratings)
Recommendable to most
Sort by: Popularity | Date | Rating
Posted over 1 year ago by Joola69 from United States with 2649 ratings
Enjoyed a bottle of Rum XM 5y from Guyana. Decent bottle and label design. Cheap at $19 per bottle. Amber color. Plenty of oak, vanilla and alcohol to your nose and palate when neat sipped. Strong and dry burn at the end. Mix this up with your favorite soda and it's surprisingly good mixer rum.
Posted over 3 years ago by Tomas from Czech Republic with 137 ratings
Tried this one as a blind choice and we all were very pleasantly surprised with it. Full body with decent sweetness for a great price.
Posted over 4 years ago by Adrian from United Kingdom with 22 ratings
I tried this rum whilst on a visit to its country of origin (guyana). The captain morgan of this world doesn't come close in comparison to brand. The taste the colour, the aroma makes me want to explore other brands of the XM group.
I think I have gone up in the league of rum tasting.
Easily access Rumratings while on the go by adding a shortcut to your home screen. All you have to do is click the icon and then Add the RumRatings App


text: My name is Jorge Luis Figueroa, I am a native of Aibonito, Puerto Rico. I am in my third and last year of my MFA candidacy in Acting at the California Institute of the Arts. I am a current non-union actor and I recently won the Grand Prize from the ArtChangeUS organization for a play I produced together with Bad Boy Sad Boy, a production company I co-founded. I received an HOLA Award in 2017 for Best Featured Actor and in 2015 for Outstanding Ensemble Cast. In 2015 I graduated from The American Academy of Dramatic Arts, and in 2017 from Hunter College with concentrations in acting and film production. I am fluent in both Spanish (Native) and English. I aspire to be in, and produce, projects that challenge me as an actor and make me bolder in my choices each day. Not only have I worked (and keep working) on my craft, but I also understand the importance of being a smart business person who recognizes the significance of self-marketing and knows how to manage my time and finance in this ever-changing industry.


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Travel Management
|June 03, 2011
Flight Centre Retail Travel Brand Takes Off In Singapore
|TRAVEL agency group Flight Centre Limited (FLT) has opened its first leisure store in Asia, with a new shop opening in Singapore.
The Australia-based company, which has a comprehensive corporate travel presence in Asia, opened (June 3) its first Flight Centre-branded leisure travel shop in Singapore's Stanley Street.
The Singapore shop will offer the company's famous lowest airfare guarantee and its trademark "unbeatable" leisure fares and rates.
The store's experienced travel consultants -- both native English speaking and bi-lingual -- will offer a full range of airfares, accommodation, car hire, tours, insurance, cruises and other travel products.
FLT's executive general manager for Singapore, Suyin Lee, said the introduction of the Flight Centre brand to Singapore would fill a niche in the local market for specialist leisure travel services and products at globally competitive rates.
"Flight Centre has an extremely strong global presence in leisure travel and our aim is to capitalise on this by offering the brand's powerful mix of price, product and service in the Singaporean leisure market," she said.
Over recent years we have developed a solid understanding of the needs of both expatriate and local travellers through our corporate travel operations in Singapore and other parts of Asia.
Singaporeans are frequent travellers and expect highly personalised and responsive service from knowledgeable and professional consultants.
"We invest heavily in destination and product training in addition to service excellence to create a different experience for our customers in a very competitive market."
Flight Centre brand is the best known and most successful business in the Flight Centre Limited group of companies, which also includes global corporate travel brand FCm Travel Solutions.
FLT's global network currently comprises more than 2,000 stores and businesses across Singapore, Greater China, Australia, New Zealand, India, the United States, Canada, the United Kingdom, South Africa and Dubai.
The new Flight Centre store is located at 29 Stanley Street, Singapore.


text:
re:match - our international matchmaking-tool is online!
Check out our previous posts on this year's re:publica and the Enterprise Europe Network (EEN). Today we are happy to announce that our international matchmaking-tool re:match has gone online. re:match is a B2B platform, open to all re:publica visitors, which offers optimal networking opportunities.
re:publica and the EEN are joining forces this year! Entrepreneurship, IT business, EU funding programmes (Horizon 2020), knowledge exchange, and networking are the core themes in re:match. So if you are looking to broaden your personal and business network, check out this service to make new contacts.
It's easy to get involved, all you need is a valid re:publica ticket. Naturally, registration for all participants is free of charge. Get started here:
Whether you are a business newbie or a veteran businessperson, use re:match today to plan your meetings at re:publica and promote yourself and your business!
*Photo CC-BY 2.0 by Gregor Fischer


text:
Liverpool are expected to strengthen their squad in the summer transfer window, and have been linked with a move for Leeds United winger Jack Clarke.
Clarke has been a key player for Leeds in recent months after earning the trust of Marcelo Bielsa, and has put in some stellar performances.
According to Express Sport, Liverpool boss Jürgen Klopp is keen to add Clarke to the squad, and further strengthen what is already a good squad.
Jack Clarke – Factfile
The 18-year old has made 16 appearances already in the Championship, though a majority of them have come off the bench.
Bielsa often used Clarke as a second-half substitute, but the teenager has seen more starts in the last month or so.
Clarke has managed two goals and two assists so far in the Championship, and has helped the Whites challenge for promotion under Bielsa.
Why Clarke is a good fit for Liverpool
The team's style of play under Bielsa has excited the fans and barring maybe Wolves from last year, the Championship has rarely seen football so easy on the eye.
That's where players like Clarke have played a key role. The 18-year old is a technically gifted footballer, and has shown the maturity that belies his age.
Leeds have played an aggressive brand of football, which involves a lot of work off the ball. Liverpool, unlike previous seasons, have played a more pragmatic brand of football, but pressing is still a key facet of Klopp's style.
Players like Sadio Mane, Alex Oxlade-Chamberlain, and Naby Keita were signed because they were used to playing under a pressing blueprint, and the same applies to Clarke.
Most of Clarke's appearances have come on the right wing, but he is versatile enough to feature on the left as well. The Englishman has played five times on the left this season.
Klopp prefers wingers who can press, and take on defenders; traits that Clarke possesses in plenty. The teenager is agile, has a trick or two up his sleeve, and has shown that he can be a hard layer to stop when played in the right set-up.
Klopp has developed young talents like Shinji Kagawa, Mario Götze and Robert Lewandowski in the past, and Clarke might become a pretty good acquisition if the Reds manage to sign him.


text:
African Growth and Opportunity Act: Advancing the Role of Agriculture in US-Africa Trade
Agri-Pulse and The Chicago Council on Global Affairs are teaming up to host a monthly column to explore how the US agriculture and food sector can maintain its competitive edge and advance food security in an increasingly integrated and dynamic world.
By Grace Burton and Louise Iverson
The debate over fast-track authority, more formally known as the Trade Promotion Authority (TPA), has dominated the news headlines and is likely to remain at the forefront of policy discussions about US trade policy for years to come. The terms of the President's trade authority and the level of transparency regarding negotiations on international trade agreements continue to spark debate. But even with all of the rancorous disputes around trade policy, there is one measure that consistently draws bipartisan, bicameral, and almost unanimous support: the African Growth and Opportunity Act (AGOA).
Signed into law by the President on June 29, the reauthorization of AGOA originally passed the Senate with a decisive 97-1 vote and the House 394 to 37. As the focal point and keystone for US-Africa trade relations, it is a preferential trade agreement created in 2000 with the intent to stimulate economic development through export-led growth and help integrate Africa into the broader global economy. While we applaud the 10-year renewal of such an important agreement for the development of African economies, the legislation is a missed opportunity to expand AGOA's reach to benefit a wide range of industries and further foster diverse economic growth. Despite its crucial role for some sectors, such as natural resources, AGOA does not offer nearly as much to a sector that employs approximately 65 percent of Africa's labor force: agriculture. Of Africa's $52 billion in food and agriculture exports in 2012, less than 1 percent were destined for the US. In that same year, only 5 percent of the trade facilitated by AGOA was related to agriculture and food.
Continue reading on Agri-Pulse>
The Global Food and Agriculture Program aims to inform the development of US policy on global agricultural development and food security by raising awareness and providing resources, information, and policy analysis to the US Administration, Congress, and interested experts and organizations.
The Global Food and Agriculture Program is housed within the Chicago Council on Global Affairs, an independent, nonpartisan organization that provides insight – and influences the public discourse – on critical global issues. The Council on Global Affairs convenes leading global voices and conducts independent research to bring clarity and offer solutions to challenges and opportunities across the globe. The Council is committed to engaging the public and raising global awareness of issues that transcend borders and transform how people, business, and governments engage the world.
Support for the Global Food and Agriculture Program is generously provided by the Bill & Melinda Gates Foundation.
1,000 Days Blog, 1,000 Days
Africa Can End Poverty, World Bank
Agrilinks Blog
Bread Blog, Bread for the World
Can We Feed the World Blog, Agriculture for Impact
Concern Blogs, Concern Worldwide
Institute Insights, Bread for the World Institute
End Poverty in South Asia, World Bank
Global Development Blog, Center for Global Development
The Global Food Banking Network
Harvest 2050, Global Harvest Initiative
The Hunger and Undernutrition Blog, Humanitas Global Development
International Food Policy Research Institute News, IFPRI
International Maize and Wheat Improvement Center Blog, CIMMYT
ONE Blog, ONE Campaign
One Acre Fund Blog, One Acre Fund
Overseas Development Institute Blog, Overseas Development Institute
Oxfam America Blog, Oxfam America
Preventing Postharvest Loss, ADM Institute
Sense & Sustainability Blog, Sense & Sustainability
WFP USA Blog, World Food Program USA
Commentary - The Future of Food Aid
Earlier this week, I attended the Chicago Council's Symposium on Agriculture and Food Security, and for the second year in a row heard from experts in the fight against hunger.
Commentary - High Food Prices and Dietary Quality: Who Pays?
When policymakers talk about rising food prices, they lump all food together -- but what they mean is cereal prices.
Commentary - From Dairy Farm to the Global Table
I was fortunate to be in attendance as the Chicago Council on Global Affairs released their new report, "Advancing Global Food Security: The Power of Science, Trade, and Business" at the 2013 Global Food Security Symposium.
Live Blog - Calling On Congress, U.S. Government To Make Food Security A Higher Priority
Congress should commit the United States to a global food and nutrition security strategy, and the vice president should oversee it, a new report from The Chicago Council on Global Affairs recommends.
Commentary - What Would Norm Say?
Given the decade-long relationship I had with him in building the World Food Prize, I am sometimes asked about what the late Nobel Peace Prize Laureate Dr. Norman E. Borlaug might say about a particular topic.
Live Blog - Chicago Council: Agriculture and Health Nexus Panel
"How many enemies can I make on this answer?" Dr. Shapiro boldly called for large agribusinesses like Monsanto, Syngenta, and DuPont to make all their information public and readily available. Dr. Shapiro criticized these companies for not being entirely honest about their goals and motivations.
Live Blog - Chicago Council: A Discussion on "A New Science of Agriculture to Advance Global Food Security"
The complex challenge of hunger requires a unique collaboration between different sectors, experts, and communities.
Commentary - Addressing Food Security Beyond our Food Supply
I'll soon be attending the Symposium on Agriculture and Food Security. It doesn't happen often that world leaders, researchers and philanthropists have the chance to gather for two days to discuss the progress made in the past year – and the work that's still ahead – in addressing food security challenges.
Live Blog - Chicago Council Global Food Security Symposium, Raj Shah: "All hands on deck"
Raj Shah, Administrator of the U.S. Agency for International Development, described the Obama administration's—and more broadly, civil society's—efforts to fight global hunger as an "all hands on deck effort."
Live Blog - Chicago Council: Dan Glickman and Catherine Bertini's case for reengagement in food and ag issues
"Water is the great issue of our time."
Live Blog - Brazil And Food Security: A "Remarkable Story" With Lessons For Others
In 40 years, Brazil went from importing most of its staples – such as rice, beans and milk – to being a major exporter of food worldwide. How?
Commentary - Today's Challenge Requires Tomorrow's Leaders
In order to address the complex challenge of global food security outlined at The Chicago Council Global Food Security Symposium today, we need the enthusiasm of the next generation most of all.
Commentary - Stretching the Food Aid Dollar by Building Strong Local Markets
Floods, typhoons and droughts. Market fluctuations and inflation. Unhealthy government transitions and local political flare-ups. Disease-ridden crops and tainted water sources. All of these shocks can devastate any country, but for nations combatting poverty, food insecurity and malnutrition, disasters often precipitate acute food security outbreaks that result in suffering and loss of life.
2013 Global Food Security Symposium
The Chicago Council on Global Affairs will be hosting its fourth Annual Global Food Security Symposium tomorrow, starting at 830 am EDT. The event's agenda can be found here.
Commentary - Community Development Key to Sustainability Efforts
Now, more than ever, solutions to serious issues facing the world—hunger, poverty and environmental degradation—must be sustainable.


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The administrators of the site have now decided to address the matter of nudity and perverted behavior on the popular forum, doing this through some slight adjustments to the login page.
In a very short and concise manner, it is encouraged that the users remain fully clothed.
The reason behind Chatrandom's success is simple, they provide an easy to use platform for people from all around the world to be able to easily connect with each other.
The site has made the world a smaller place and users have enjoyed the services because they have the ability to meet people from different cultures instantly.
Chatrandom is a free Chatroulette alternative that connects people using their webcam.
This random chat has taken off and become one of the top sites like Chatroulette in the last few years.
:-P Ironically, neither of us was looking for any sort of partner and we were both not single at the time. Not that I have ever used Omegle, but I believe it's the latter. So, even though they're only on for 5 minutes, there's enough of them to be noticeable. Bernhardi ---- Germany and the Next War I met my (eventual) wife on Omegle. Not really relevant but I saw Omegle and wanted to share. As in, some troll-ish dude decides "hmm, I want to fap, let's hop on Omegle and terrorize some people! __________________ The efficiency and success of the Italian aviators in Tripoli are noteworthy, but must not be overvalued. We met in 2009, married last year, and she's moving to the States in 2 weeks on a green card. :-P Ironically, neither of us was looking for any sort of partner and we were both not single at the time. About ibtisam omer Hi and hello I am twenty three years old and for the past four years I have studied sociology and media studies in three different places: Stockholm, UK and Hong Kong.I graduated at the University of Essex in July and after that spent a few weeks interning at Global Grind in NY.


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Q&A for my webinar on scams targeting language professionals
Recently, I presented a webinar on scams targeting language professionals. The webinar is now available on demand, for free. As announced during the webinar, I'll be answering some questions that were asked during the Q&A at the end of the webinar. Q regarding CV theft scam: Why do you call it "identity theft" if they…Read More/Weiterlesen


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Goliath Triple
The Brewery
+32 (0) 68 28 79 36
Beer Style
The Beer
Ath is the city of giants. You can watch them on parade during the annual Ducasse d'Ath procession held over the fourth weekend of August. Goliath – Gouyasse in the local dialect – always heads the march.
Not far from the parade route is the medieval fort of Irchonwelz, dating back to the 12th century. This is where Pierre Delcoigne and Vinciane Wergifosse set up the Brasserie des Légendes. The first Gouyasse flowed from the tanks in 2000.
Brasserie des Légendes uses natural ingredients only, hops from Poperinge for example, and re-ferment their beers without any added sugar.
In the brewery your eye is first caught by the wood-clad, cast iron mash kettle from 1890, and the imposingly tall copper boiling kettle that was installed in 1930.
In the Goliath range are this Tripel, the Goliath Blonde, and Winter. Brasserie des Légendes also produces Quintine - the witches' beer that is brewed at the brewery's Ellezelles site - Hercule Stout, Saison Voisin, Ducassis (an organic, gluten-free fruit beer) and Legends Harmony.
Strong blonde tripels are extremely popular in Belgium, so most brewers offer their own version, as Brasserie des Légendes do in the name of the giant Goliath.
Goliath Triple is a top-fermented beer that also re-ferments in the bottle.
Goliath Triple is brewed with well water, a house yeast, aroma hops and pale malt.
Colour & Transparency
When poured correctly in a dry and clean glass this triple takes on a clear golden-yellow colour below a cloud of white froth.
Serving Temperature
Serving Glass
Goliath Triple is served in an elegant degustation glass on a tall stem. It preserves the head and enhances the aroma of the beer for the drinker.
Character, Tastes & Aromas
This is a fruity, full-mouthed, balanced and quite hoppy beer with a long, dry, bitter finish.
Beer and cheese make a great couple, especially when the beer is this full-mouthed, rather dry triple. It is also delicious with a fine cut of beef, or fish.
As with all Belgian beers, tastes and preferences are always personal so don't be afraid to experiment when it comes to finding the perfect pairing!
Keeping and Storage
Goliath Triple can be stored in the bottle for 36 months. In kegs it will keep for 9 months.
This is a beer developed and brewed to be enjoyed young, as with all beers of this type it is not conceived to be stored.
When stored keep your bottles upright in a cool, dry and dark environment. Light, moisture and heat are the three main natural enemies for any beer.
Bottle ✔ On Tap ✔
Available in bottles (33cl, 75cl, 150cl), and on tap (20l, 30l kegs).
As with the other beers brewed by Brasserie des Légendes you will find this beer in specialised shops and bars around Belgium.
When travelling around the brewery's home province of Hainaut you will have to make a real effort not to come across this one in fact.
Outside of Belgium you will be able to pick some Goliath up via the usual channels.
Other Brasserie des Légendes Beers
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GUEST BLOG by Certified EOS Implementer Sean O'Driscoll
Are you a Mac person, or a Windows person? That question gets asked a lot, with some people very polarized in one direction. They each have an operating system that provides a foundational layer, driving how you use the systems and how applications run on the system. A Mac and a Windows PC each have a set of protocols, specific to their operating system.
As EOS Implementers we believe that all companies should run on a single "operating system" with a consistent set of protocols for running a business. While we advocate for EOS as the best system (in the right situation), it does not have to be EOS. The important point is that there is an underlying foundational operating system that drives consistency and effectiveness in your business.
Questions to ask periodically:
- Does our operating system deliver all we want from the business?
- Did we consciously decide on the operating system, or has it simply evolved?
- As a foundation for our business, could it be stronger?
- Are there things about the way we operate that we could do better:
- People optimization?
- Meeting effectiveness?
- Focus and prioritization?
- Level of process consistency?
- Alignment around our overall plan?
The stronger you business operating system is, the stronger your results will be.


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Is This Your Listing? Are you the owner of PACC of Port Saint Lucie in Treasure Coast Florida? Send us more details! Claim Your Business Or Contact Us
Portuguese American Cultural Club a Non-profit organization. We are a social club for the community of Port St. Lucie.
Please stop by and visit us. For more information on our club you can reach our President Carlos Cardoso @ 772-528-2759 or Secretaries @ 508-496-4499 Tony Farias or 772-342-3921 Gloria Sousa
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This is version v3.09.2, which features a beta release of a new NPC, Treads-the-Ashes, written by Lindsey Lorraine and voiced by James McLauchlan. You can initiate the encounter by walking along the eastern coast, a few miles north of the Wreck of the Winter War.
I also altered the aliases in Spell it Out for Me so they don't fill if the target is already dead. Also conditioned the marker on Lagdu and Lurgok not to appear unless they've been enabled.
All Fixes and Tweaks from v3.09:
- Treads-the-Ashes (Alpha)
- Added script to remove Dro'bar's coin from your inventory
- Removed objective markers in Spell it Out for Me on dead targets, added Lurgok as target and conditioned Lagdu's marker to having started Brakh's quest
- Alassea now requires a brief conversation at the Temple of Mara to qualify for marriage
- Ability to tell Rumarin whether to use bow or sword
- Added Wolves of Jorrvaskr to Alassea's playlist
- Added temporary restraints to patrons in Pit Dogs so they don't run around during the fight
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- Changed Robber's Refuge patron so she doesn't have the name of a terrorist organization
- Removed "A Warrior's Life" from Ygglief's list of duets
- Upon completion of A New Dawn, Olivia and her acolytes are now removed from their factions allowing them to be raised as thralls without consequence.
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Aphrodite Sterling Silver Stacking Birthstone Ring is a vintage inspired way to stack the birthstones of those that you love.
About This Personalized Piece
About Our Personalized Jewelry Collection
The eclectic collection of hand-stamped and engraved charms is further guided by Zoe's eye for exquisite craftsmanship, iconic motifs and timeless style that can be worn day and night. Every personalized piece is crafted of ancient metals and semi-precious stones, and hand-wrought to create luminous finishes.


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9th annual Newton Hill 5K Race Series 6:30 Tuesdays through Aug. 30. Elm Park, Highland Street and Park Avenue, Worcester.
Music Big Jon Short, 8 p.m., Tuesdays. Armsby Abbey, 144 Main St., Worcester.
Canoes and Paddleboats at EcoTarium 1-3 p.m. Tuesdays through Aug. 23. $5 per boat for 20 minutes plus museum admission; members, free. $12; seniors, college students with valid ID and children 2-18, $8; children 1 and younger, free. 222 Harrington Way, Worcester. (508) 929-2700.
Post Road Chorus Rehearsals for women 18 and older, 7:15 p.m. Tuesdays. Briarwood Continuing Care Retirement Community, 65 Briarwood Circle, Worcester. (508) 852-1327, (508) 829-3374 or www.postroadchorus.org.
Music The Bobby Gadoury American Songbook Sing-a-long, 9 p.m. July 26. Nick�s Bar and Restaurant, 124 Millbury St., Worcester. (508) 753-4030.
Performance �Love Trilogy,� presented by Richard Clark and Dianne Giamarco. 2 p.m. July 26. Briarwood Continuing Care Retirement Community auditorium, 65 Briarwood Circle, Worcester. www.briarwoodretirement.com.
Podiatry Clinic 12:30-3 p.m. July 26. Worcester Senior Center, 128 Providence St., Worcester. (508) 799-1232.
American Red Cross Blood Drive 2-7 p.m. July 26. Coldbrook Campground, 864 Old Coldbrook Road, Barre. Donors will receive a voucher for a free carton of Friendly�s ice cream. www.redcrossblood.org.
Summer Concert Dixieland Stomp, 6:30-8 p.m. July 26. Free. On the Common, Brimfield. If raining, held at Hitchcock Free Academy, 2 Brookfield Road, Brimfield.
Jungle Encounters Open to all registered participants of the summer reading program and their families. 6:30-7:30 p.m. July 26. Merriam-Gilbert Public Library, 3 West Main St., West Brookfield. (508) 867-1410 or www.wbrookfieldlibrary.org.
Concert and Bake Sale Peter and Ellen Allard, 10 a.m. July 26. $5; family maximum, $10. Charlton Public Library, 40 Main St., Charlton. email@example.com. Proceeds to benefit Healthy Families in Southern Worcester County.
Story Time 10 a.m. July 26. Free. Fitchburg Public Library, 610 Main St., Fitchburg.
Exercise Classes Yoga 10 a.m. $12.; Zentangle by YouTube, noon. $5 for supplies for first class; Resistance Band Workout 3:30 p.m. and Ab/Core Workout at 4:45 p.m., both $12. July 26. Simonds-Hurd Complementary Care Center, HealthAlliance Hospital � Burbank Campus, 275 Nichols Road, Fitchburg. (978) 665-5800.
Central Massachusetts Genealogical Society Meeting Robert Young will give a talk on a re-enactment of Henry David Thoreau�s �Walk to Wachusett,� 7 p.m. July 26. $2. American Legion, 22 Elm St., Gardner. (603) 899-6806.
Farmers Market 3-6:30 p.m. Tuesdays. Red Barn, 52 Shrewsbury St., Holden. (508) 867-6065.
Twin City Toastmasters 7 p.m. Tuesdays at different locations. To confirm location and time, call (978) 874-1665 or www.twincitytoastmasters.com.
Preschool Story Time 10 a.m. July 26. Leominster Public Library, 30 West St., Leominster. (978) 534-7522, ext. 201.
Art Class Paint an art apron, 1-3 p.m. July 26, $15. Leominster Art Center, 69 Main St., Leominster. (978) 728-9872 or www.leominsterartcenter.com.
Cupcake Decorating Party for Teens Prizes awarded for most creative confections.2:30-4 p.m. July 26. Registration required. Leominster Public Library, 30 West St., Leominster. (978) 534-7522, ext. 5, or www.leominsterlibrary.org.
Colors Around the World Story and then make a rainbow fish sun catcher, 3 p.m. July 26. For children 4-7. Leominster Public Library, 30 West St., Leominster. (978) 534-7522, ext. 201.
Brain Injury North Central Support Group 7 p.m. last Tuesday of the month. Lunenburg Public Library, 1023 Massachusetts Ave., Lunenburg. firstname.lastname@example.com
Kamp Kidgets Enjoy a $1 movie at Regal Cinema and pirate-themed activities, noon-2 p.m. July 26. $5 annual membership fee. Solomon Pond Mall, Food Court, 601 Donald Lynch Blvd., Marlboro. www.simon.com/kidgits.
Millbury Has Talent 6:30 p.m. July 26. Millbury Public Library, 128 Elm St., Millbury. (508) 865-1181.
South America Drop-in Crafts 10 a.m.-7 p.m. July 26. Northboro Free Library, 34 Main St., Northboro. (508) 393-5025.
Tai Chi Classes 4-5 p.m. Tuesdays. $3. Senior Center, 119 Bearfoot Road, Northboro. (508) 393-5035.
Yoga Classes 5-6 p.m. Tuesdays. $3. Senior Center, 119 Bearfoot Road, Northboro. (508) 393-5035.
Beginner Line Dancing Classes 11 a.m.-noon Tuesdays. $3. Senior Center, 119 Bearfoot Road, Northboro. (508) 393-5035.
Volunteer Days Learn about nature and assist with a variety of property, maintenance and ecological management projects, 9:30 a.m.-12:30 p.m. Tuesdays. Free. For ages 16 and older. Wachusett Meadow Wildlife Sanctuary, 113 Goodnow Road, Princeton. (978) 464-2712.
Co-Dependents Anonymous Meeting 7:30 p.m. Tuesdays. Veterans Inc., 59 South Main St., Shrewsbury. (508) 688-7270.
Annual Summer Talent Show for children 5 and older, 6:30 p.m. July 26. Shrewsbury Public Library, 609 Main St., Shrewsbury. (508) 842-0081.
Summer Concert Wolverine Jazz Band, 7 p.m. July 26. Free. Southgate at Shrewsbury Park, 30 Julio Drive, Shrewsbury. Bring lawn chairs and blankets. If rain, held in the Southgate Theatre.
Women for Sobriety Self-Help Program 7-8 p.m. Tuesdays. Mount Olivet Lutheran Church, 34 Prospect St., Shrewsbury. (508) 842-9158 or firstname.lastname@example.com.
Outdoor Concert Acoustic night with live performances, 7 p.m. July 26. Free. St. John�s High School, 378 Main St., Shrewsbury. Bring lawn chairs or blankets. If rain, held in the Ryken Center on campus.
International Singing Adults are invited to sing international rounds with Mary Anne Slack. 6:30 p.m. July 26. Richard Sugden Library, 8 Pleasant St., Spencer. (508) 885-7513.
American Red Cross Blood Drive 2-7 p.m. July 26. Sturbridge Host Hotel and Conference Center, 366 Main St., Sturbridge. Donors will receive a voucher for a free carton of Friendly�s ice cream and can register to win Red Sox tickets. www.redcrossblood.org.


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Fobbs Quality Signs is a family business with over 27 years of experience in the traffic control industry. We pride ourselves on top notch customer service as well as excellent products. Our vision is to be able to know the individual needs of our customers and to guide them in making the best decisions for their companies.
The mission of Fobbs Quality Signs is to provide quality goods and services and exemplary customer service while building one relationship at a time.


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Ask the price: 780,000 euros
Finca is a fairly unspecified country in Benimussa. It is located on a large forest land, which gives you lots of opportunities to create it according to your desire.
It is located in a very calm and quiet area and offers a panoramic view of verdant trails. Longer trees protect from hot sun on hot summer days and provide a shadow spot where you can relax and listen to birds' music. On the cold winter day you can make yourself comfortable in front of Ibizan Stove and spend a night with a movie with your loved ones.
There is a small cottage that can ideally be converted into a small guest studio or used as a workshop.


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Hot Deal
Buy early, Get 30% Off
The second sale of the 55th anniversary of the Niseko Moiwa Ski Resort. Chance to buy 30% off lift tickets from noon 1st September to 31st October.
We look forward to seeing you in Niseko Moiwa this winter!
>>Click here to purchase (Noon on September 1)
Super Get In Early information (Adult lift pass)
The season tickets and 1-day tickets for adults have been sold out. The rest of season tickets and one-day tickets are still available for senior and younger. Don't miss this special opportunity to enjoy Niseko Moiwa at an affordable price this winter.
>>Purchase Lift Pass online
Hot Deal
Super Get In Early will restart 14PM(JST) 18August,2020
Sales of 55% off Super Get In Early Discount will resume from 14:00 on Tuesday, August 18. We look forward to seeing you on the slopes this winter!
>>Click here to purchase from 14:00 on August 18th
Notice of super early discount suspension
Apologize to everyone who accessed today's Super Early Discount, and we will stop Super Early Discount and start over again.
We apologize for wasting your precious time. Thanks for your understanding.
Hot Deal
Get 55% off for your 20-21 Lift Pass!
Niseko Moiwa Ski Resort will sell 55% off Super Early Bird discount for a limited time and number of lift passes to commemorate the 55th anniversary of the 20-21 season!
The sale will start from 18:00 on August 14th. Do not miss this opportunity!
>> Click here to purchase
Actions for Covid19
Niseko Moiwa Ski Resort will implement measures to prevent the spread of infectious diseases based on the new Hokkaido style established by Hokkaido. We are looking forward to welcoming you to Niseko Moiwa.
>>>Details of measures against infectious diseases
Notice of Restaurant Raphael Closure
Restaurant Raphael will be closed on 1July 2020 until 31September 2020.
19-20 Winter season End
On April 5, 2020, we closed our winter business this year.
Please check our website or SNS bout next winter season. We are working hard to maintain lifts and slopes to see your smiles.
With love to everyone who came to Niseko Moiwa Ski Resort.
Check our FB page and daily report
We are uploading daily slope condition, status of lift operation, what you want to know in advance, every morning around 8AM. Please check and come to Niseko Moiwa!
>>Go to NisekoMoiwa FB page
Know Niseko Moiwa Ski Resort before you go and get POW!
Guests can enjoy healthy meals made with Niseko and Hokkaido ingredients at Restaurant Raphael, and its rooms are spacious, which are larger than normal capsules and have ample facilities.
Restaurant Raphael
Restaurant Raphael is a casual restaurant which is like a secret getaway for the locals and utilizes local ingredients.
[Business Hours] Open from August 1 to November 29 in 2020.
Breakfast: 7am-9am Lunch: 11am-3pm
Reservations: +81(0)50-3171-5688


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