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Milebuilder: Chichester to St Malo £250 per person SOLD OUT
August 18, 2019 @ 6:00 pm - August 21, 2019 @ 8:00 am£250
Starts Chichester Harbour, ends St Malo
Yacht: Jalapeno.
Skipper: Dhara Thompson
You'll be onboard from 1800 on Sunday 18th August for dinner and a briefing, before a brief rest. The aim, weather permitting, will be for an overnight passage, leaving Chichester harbour around midnight, aiming for St Peter Port in Guernsey. Our back up plan will be Braye Habour on Alderney. Tuesday we'll be sailing to St Malo. The two days will involve keeping watches, crossing the channel shipping lanes and negotiating the tidal streams of the Channel Islands. On this milebuilder there will be plenty of opportunity to brush up on your navigation skills as well as gain some useful nautical miles. Everyone is welcome to stay onboard Tuesday 20th. The St Malo to Portsmouth ferry departs 1030 On Wednesday, arriving Portsmouth 1820, with foot passenger fares at £39 per person. You will need to book your own ferry place. No previous experience required, although you may like to try a shorter trip first if you haven't sailed before.
Distance: Around 160 nautical miles


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Project: Animation FilmCategory: TV CommercialCountry: Germany
This is a one clip picked from one of our best film Chief's Daughter. Its character designer game is best in quality. Its character is also modelled by us. This character is made in Maya, ZBrush, V-ray, 3Ds Max and photoshop and its animation is made in After effects by Game Assets Creation.
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Tad came into rescue from a shelter in Texas after his human died and there was no pace for him. Tad is loving and has a great attitude, he is shy at first, as he has only been with elderly people and has been thru a lot of changes in a short time. Tad is in need of a home that will give him time to decompress and warm up and know he won't be abandoned again. Tad is neutered, up to date on vaccines, heartworm negative, micro chipped, and flea/tick treatment. If interested in adopting, please email email@example.com ask for Tad.
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Of Cobden, passed away peacefully at his residence surrounded by his loving family on Friday May 24, 2019 in his 82nd year. Dominic Bielaskie son of the late Anthony and Rose Bielaskie nee Palubeskie. Beloved husband of Jenny Bielaskie nee Power. Loved and cherished father of Catherine (Derick MacKenzie) and Kevin (Zabrina) Bielaskie. Loving grandfather to Kayla, Jenna, Mitchell and Shaylyn. Also survived by siblings Jean (late Harry Haley), Genevieve (Clarence Visutski), Theresa (Reynolds Timmins), Rita (late Gib Dodd), Leonard (Leona) Bielawski, Phyllis (late Ron Carrigan), Vincent (Sheila) Bielawski, Richard (Carla) Bielawski, Ursela (late Steve Desjardin), Raymond (Maureen) Bielaskie, Marilyn (Michael Wollock) and brother-in-law of James (late Marilyn) Power, Don (Rita) Power, Lucretia (Willard Brisbois), Theresa (Jim Riopelle), Pat (Tom Makela) and many nieces and nephews. Predeceased by a brother Joseph (late Nettie) Bielaskie, sister-in-law Colleen (late Steve Lalonde), Oswald Power, Helen (Gerry Tracz) and Arnold (late Ailleen) Power. Friends may call at the Fraser-Morris and Heubner Funeral Home Cobden, Thursday May 30, 2019 from 2-4 and 7-9pm. and Friday from 9:30 until 10:30am .Mass of Christian Burial will be celebrated in St. Pius V Roman Catholic Church Osceola, Friday at 11am. Interment St. Pius V Cemetery Osceola. As expression of sympathy donations to Ottawa Hospital Leukemia Program for M.D.S. or the University of Ottawa Heart Institute would be appreciated.
To send flowers to Dominic's family, please visit our floral store.


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Rašykite mums
Key Business Stakeholders Play Critical Role in Solving Complex Data Security, Regulatory Compliance Issues, IDC Study Finds
The security of business applications in the cloud requires security teams to engage with business analysts and data specialists who have the most visibility. This and other interesting facts can be found in the IDC Data Services for Hybrid Cloud survey of more than 400 IT security and line of business personnel. Atsisiųsti dokumentą


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There is plenty of entertainment medium today that helps us get the daily dose of entertainment. With the inclusion of live streaming services, the level of entertainment has been increased to a different level. People can now watch their favorite shows and movies in these streaming services.
Though there have been plenty of entertainment medium popped up over the years, there are some things that never lost their prominence in the entertainment world. We are talking about movies. One of the most influential and impactful medium of entertainment that is popular among people of all ages, the significance of film never decreased an ounce. Sometimes people take movies for granted, but only little do they know that videos are the most powerful source of communication that can be used to send the desired message to the audience.
By design, movies are meant for entertainment purposes, but that is not all. Videos that are filmed with the right intention can touch hearts and teach us many things in life. Generally, movies are deemed as the dramatic representation of human emotions that can be used to send in the required message to the audience; a life without film is not something that we cannot imagine. Though they don't play a significant role in our day-to-day lives, their absence can certainly bring monotony in lives.
Why Do We Love the Movies?
Due to the broad exposure and ability to entertain large masses, movies are considered as the ideal way to channelize ideas to the audience that are otherwise hard to direct. The statement, as mentioned above, cannot be used for all the movies, as certain movies cannot be deemed as a socially acceptable one.
There are plenty of reasons that states that movies are essential for us. Take a look at some of the primary reasons why films are still a part of the entertainment industry.


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Biloban crib mattress pad guarantees your little one with snug and comfy in his crib.
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UNFETTERED DREAMING: (Level 1)
Before you sleep, tie a length of cloth soaked in rare herbs about your eyes. Meditate upon your dreams gone past, and focus your spirit strength. Let go your Gnosis, lie down to sleep, and your dreams will take your spirit to Chimerae, where you will dream true. There are other forms of this rite, but all require a Gnosis, and all take you to a Chimerae (dream realm) where true dreams are had.
[Type: Mystic Rite / Theurges]
(Source: Unknown)
Community content is available under CC-BY-SA unless otherwise noted.


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Comment on Maternity & Beyond: The Henkaa Iris Convertible Dress by Brittany.
I need one of these! Watched the entire video and the Christine and Lynne styles are fabuuuulous. I wonder how forgiving this material is in the dead of summer…because if it doesn't cling and feels cool, I'd be all over it!
Recent Comments by Brittany
6 Questions to Ask Your Kids When They Come Home From School (Printable)
Hey big man, Jayden! I'm so glad to see this because I am already sounding like a broken record when asking EB how her day went. I try to say things like "Did anything make you happy/sad/laugh?" and we go from there. Most times she blows me off so this printable will be SO helpful.
Golden Tote Got It Right!
Oh my darling, I LOVE alllll of these on you but especially that last piece. It's so beautiful and so you. You look fabulous in it!
Saying Yes To This Boho Summer Dress
Can this be any more perfect? I love everything about this look! Chic and boho and sexy in the back. Yes ma'am. Werk!
DIY Disney Stroller Sign & Autograph Books + Printables
This is absolutely adorable. We may be taking a trip next month or so (depending on how un-lazy I'm feeling, ha!) and we'll definitely be printing this off. I LOVE personalized stuff.
Preschooling Through Walt Disney World
Yes to all of this. I've got a 3-year old too and you just have to know that a meltdown will happen. It's A LOT for them but you're right. It's all soooo worth it. I knew you guys would love the resort. We did Art of Music in October and if I wasn't so pregnant, I would have been swinging from the quarter notes. So glad that you guys had such a memorable time!
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If cracks or damage to the vibration damper are visible or if the hub and belt pulley are no longer connected, replace the vibration damper. Check all belt-driven components for damage. Spin the alternator by hand with the drive belt removed. If the alternator rotates freely without loud grinding noise or resistance, the alternator is OK.Get Price
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If you have had difficulty getting grinding wheels balanced, this article may prove to be helpful. I have a 6 inch Craftsman bench grinder with a 1/2" arbor. That means that when I buy a new grinding wheel, it will likely have plastic bushings to reduce the 1" hole in the wheel to a 1/2" hole for the shaft.Get Price
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Cristiano Ronaldo scored twice as holders Real Madrid thrashed Apoel 6-0 in Cyprus to reach the Champions League last 16 on Tuesday, while Liverpool blew a three-goal lead in a thriller at Sevilla.
The record 12-time winners had to wait until the 23rd minute to take the lead through Luka Modric, but a run of five goals in 15 minutes either side of half-time sent Real Madrid through in style, AFP reported.
Karim Benzema put worries about his recent form to bed with a double, before Ronaldo got in on the act after the break. The Portuguese climbed highest to power a header into the corner from an inviting Marcelo cross.
And the 32-year-old, who has only scored once in eight La Liga appearances this season, scored his eighth Champions League goal this term with an excellent left-footed finish from a tight angle.
Tottenham Hotspur sealed top spot in Group H, ahead of Real, with a come-from-behind 2-1 victory at Borussia Dortmund.
Pierre-Emerick Aubameyang put the host ahead, but with Real's thumping win sending Dortmund out, Spurs leveled through Harry Kane and Son Heung-Min curled in a 76th-minute winner.
Liverpool Stunned
Five-time champions Liverpool threw away a last-16 spot as Sevilla roared back from three goals down at half-time to draw 3-3.
Liverpool looked to be cruising into the knockout stage for the first time since 2008⁄09 when Roberto Firmino and Sadio Mane both scored from flicked-on corners.
A rout similar to the 7-0 thrashing of Maribor in Slovenia earlier in the group phase looked on the cards when Firmino tapped in number three, but Sevilla staged a stirring second-half comeback.
Wissam Ben Yedder beat Alberto Moreno to nod in a free-kick, before slotting in a penalty. And Argentinean Guido Pizarro struck in the third minute of injury-time to complete the fight back and leave Jurgen Klopp's visitors deflated.
Elsewhere in Group E, Russian champions Spartak Moscow saw their chances hit by an injury-time equalizer in a 1-1 home draw with Matibor.
Sevilla will book a last-16 spot for the second straight season if they can win in Maribor on the final match day in two weeks' time, while Liverpool has to avoid defeat at home to Spartak.
Napoli Keeps Hopes Alive
Lorenzo Insigne inspired Italian Serie A leaders Napoli to a 3-0 victory over Ukrainians Shakhtar Donetsk that kept their hopes alive in Group F.
Winger Insigne made the difference with a magnificent individual effort in the 56th minute, dancing past two defenders before curling into the top corner from 25 yards out.
Further late goals from Piotr Zielinski and Dries Mertens gave their goal difference a boost.
Manchester City secured first place in the group with a 1-0 win over rock-bottom Feyenoord as Raheem Sterling scored an 88th-minute winner.
Napoli needs City to beat Shakhtar in the final round of games and sees off Feyenoord in Rotterdam to progress.
After 31 Years
Turkish champions Besiktas reached the last 16 for the first time in 31 years, as a goal from Talisca secured a 1-1 draw with Porto in Istanbul to wrap up top spot in Group G.
"We're through to the round of 16 for the first time and for that Besiktas deserves congratulations," center-back Pepe said. "We controlled the game well and in the end celebrated qualification in front of our own fans."
Last season's semifinalists Monaco is out of Europe after a woeful performance and 4-1 home loss to RB Leipzig.
The French champions saw the German tournament debutants race into a 3-0 lead through a Jemerson own goal and a Timo Werner brace, and although Radamel Falcao pulled one back, Naby Keita rounded off a stunning win that keeps Leipzig in the hunt.
Leipzig needs to better Porto's result on the last match day. The Bundesliga runner-up hosts Besiktas, while two-time European champions Porto take on Monaco.


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Donald Kimbel Bill1919 - 2011 (91 years)
Name Donald Kimbel Bill Born 7 Sep 1919 Perkinsville, Wayland, Steuben Co., New York, USA Gender Male Military Service 1944 World War II (US)
US Army, 44th Infantry Division
Died 14 Jan 2011 Wayland, Steuben Co., New York, USA Notes
- Donald K. Bill, 91, passed away peacefully, Friday, Jan. 14, 2011, at his home in the Town of Wayland.
Donald was born in Perkinsville on Sept. 7, 1919, a son of Edward and Julia Bill. Donald graduated from Wayland High School in 1937 and was a lifelong resident of the Town of Wayland.
One of the highlights of Donald?s life was his service during World War II. In 1944, he joined the U.S. Army and was sent to Europe as a replacement troop for the 44th Infantry Division. During his trip across the Atlantic, however, the peace treaty was signed and he was not needed to fight. Instead, he experienced the aftermath of the war in France, Germany, Austria and England. Upon his return to the States, Don was stationed at Fort Lewis, Wash., where he was able to utilize his typing skills to complete discharge papers for servicemen returning from the war. While in the Pacific Northwest, he enjoyed hitch hiking and riding the bus down the coast of California and up into the Vancouver area.
After discharge from the army, Donald returned to the Wayland area and resumed farming with his family. He met Phyllis Wixom from North Cohocton on a blind date and they were married April 23, 1949. Together they built their home on the Wayland-Dansville Road, with Donald and his father cutting much of the lumber for the house with crosscut saw on the farm in Perkinsville. Donald was proud of his woodworking skills and enjoyed taking classes to learn new carpentry techniques. In addition to dairy farming, Donald drove school buses first for Jack Malter, and then for the Wayland School. Throughout his life, he would continue to see the ?kids? who rode his buses and they would remember him fondly.
Donald was a member of the Wayland Lions Club, the Wayland United Methodist Church, the Wayland Historical Society, the Wayland American Legion and the Steuben County Farm Bureau. He took an active role in his children's lives and never missed attending school and community activities they were involved with. He loved traveling and camping and even though it was difficult to get away from the farm, he always found a few days at the end of the summer to camp with his family. He was always the first one up in the morning to get the fire going for pancakes and eggs. Donald loved animals and had a favorite riding horse in addition to his work horses for the farm as a young man. His dog, "Nabisco," could be found riding shotgun on trips around the farm in the truck and in later years, Don enjoyed his "grand-dogs."
After retirement from the farm, Don kept active taking long walks uptown. At age 80, he decided to participate in the weight training room at the school and a weekly exercise class. Don was proud of his participation in the Silver Sneakers program and made many friends at his classes. He also enjoyed breakfast at Jim?s Diner in Wayland and sometimes lunch and dinner there too. He was a faithful friend to his old farming buddies and could often be found visiting them at nursing homes in the area. He was an avid reader and enjoyed stopping at the library for books.
Donald was predeceased by his wife, Phyllis, in 2001; his sister-in-law, Marjorie Bill; and his brother-in-law, Elmer Mills. He is survived by his children, Sally (Craig) Smith of Houston, Texas; and Nancy (Wayne) McIntyre of Perkinsville; his grandchildren, Heather (Shane) Jaime of Katy, Texas; Justin Smith of Houston, Texas; Lynne (Jim) Pier of Macedon; and Lee McIntyre of Perkinsville; one great-granddaughter, Lilly McIntyre; his brother, Malcolm Bill of Penfield; his sister, Wilhelmina Mills of Greece; sisters and brothers-in-law, Shirley and Roy Gibson of Wayland and Barbara and Leo Wixom of West Unity, Ohio; many nieces, nephews, great-nieces and great-nephews.
Donald?s family would like to thank the wonderful crew of caregivers and the staff members and nurses at Southern Tier Hospice who enabled him to stay in his own home during the last few months. Also thanks to the Rev. Osceola Wharton, members of the church, neighbors and friends who visited, sent cards and prayers during his illness. You truly lifted his spirits as well as ours and your kindness will not be forgotten.
Friends may call 2-4 and 6-8 p.m. Friday, Jan. 21, at the Walter E. Baird & Sons Funeral Home, 300 West Naples St., Wayland. A memorial service will be at 11 a.m. Saturday, Jan. 22, at the Wayland United Methodist Church, corner of N. Lackawanna and East Avenue. Donations in Donald?s memory can be made to the Wayland Ambulance, the Wayland United Methodist Church or the Southern Tier Hospice. Those who wish to light a memory candle for Don may do so at bairdfuneralhomes.com. (GCE, January 20, 2011, pA8)
Person ID I39022 OurNorthernRoots Last Modified 29 Aug 2011
Father Edward Bill, b. 20 Jun 1889, d. 20 Apr 1977 (Age 87 years) Mother Julia Kimbel, b. 6 Mar 1893, d. 13 Apr 1989 (Age 96 years) Married 13 Mar 1914 Family ID F13867 Group Sheet | Family Chart
Family Phyllis Audrey Wixom, b. 22 Mar 1927, Bath, Steuben Co., New York, USA , d. 2001 (Age 73 years) Married 23 Apr 1949 Children 1. Living 2. Living Family ID F13869 Group Sheet | Family Chart
- Donald K. Bill, 91, passed away peacefully, Friday, Jan. 14, 2011, at his home in the Town of Wayland.
Event Map Born - 7 Sep 1919 - Perkinsville, Wayland, Steuben Co., New York, USA Died - 14 Jan 2011 - Wayland, Steuben Co., New York, USA = Link to Google Earth Pin Legend : Address : Location : City/Town : County/Shire : State/Province : Country : Not Set


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It's the Rebel Alliance vs. the Empire, David vs. Goliath. Yet the underdog is about to strike a mortal blow against Schwarzenegger and his unholy conspiracy of politicians, unions, and big business.
Despite being outspent roughly 8-to-1, the rebels are getting the truth out about the Prop 1A fraud. The polls are strongly against 1A, and getting stronger.
Here's the first No on 1A television ad:
The Empire reels
By W.C. Varones - May 12, 2009
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UPDATE: Edited to remove the guy's name. I hope nobody harasses him or his employer. He was good-natured and his sign was innocuous a...
The experts agree We're going Full MMT So start buying gold Mauldin Economics on the prestigious Camp Kotok economic gathering: ...
Gavin Newsom's executive order contradicts his public statements
Gavin Newsom's insane new executive order commands Californians to stay in their homes "until further notice" "except as...


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Effects of dynamically variable saturation and matrix-conduit coupling of flow in karst aquifers
Water Resources Research
By: Thomas Reimann, T. Geyer, W.B. Shoemaker, R. Liedl, and M. Sauter
- More information: Publisher Index Page (via DOI)
- Download citation as: RIS | Dublin Core
Well-developed karst aquifers consist of highly conductive conduits and a relatively low permeability fractured and/or porous rock matrix and therefore behave as a dual-hydraulic system. Groundwater flow within highly permeable strata is rapid and transient and depends on local flow conditions, i.e., pressurized or nonpressurized flow. The characterization of karst aquifers is a necessary and challenging task because information about hydraulic and spatial conduit properties is poorly defined or unknown. To investigate karst aquifers, hydraulic stresses such as large recharge events can be simulated with hybrid (coupled discrete continuum) models. Since existing hybrid models are simplifications of the system dynamics, a new karst model (ModBraC) is presented that accounts for unsteady and nonuniform discrete flow in variably saturated conduits employing the Saint-Venant equations. Model performance tests indicate that ModBraC is able to simulate (1) unsteady and nonuniform flow in variably filled conduits, (2) draining and refilling of conduits with stable transition between free-surface and pressurized flow and correct storage representation, (3) water exchange between matrix and variably filled conduits, and (4) discharge routing through branched and intermeshed conduit networks. Subsequently, ModBraC is applied to an idealized catchment to investigate the significance of free-surface flow representation. A parameter study is conducted with two different initial conditions: (1) pressurized flow and (2) free-surface flow. If free-surface flow prevails, the systems is characterized by (1) a time lag for signal transmission, (2) a typical spring discharge pattern representing the transition from pressurized to free-surface flow, and (3) a reduced conduit-matrix interaction during free-surface flow. Copyright 2011 by the American Geophysical Union.
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Join us on 10/5 for our next SWBC Speaker Series talk: Health Insurance & Student Access to Care.
Join us on 10/5 for our next SWBC Speaker Series talk: Health Insurance & Student Access to Care.
Who: Tristan Robinson, User Experience Engineer for GE Healthcare
Topic: Physician Responses to UI Aesthetics: Plastic Surgery or Just a Little Botox?
When: 12:30-1:20 pm, Friday, February 12, 2010
Where: Loew Hall, room 216
Abstract: Opinions about user interfaces are never in short supply. User Experience professionals are increasingly bringing rigor to the validation of product function. But what about form? Customers love products because they perform useful functions and they're easy to use. But even before they know if they'll love them, they buy products because they look beautiful and easy to use. Curb appeal is so important. I'll walk through a recent project in which we tested several aesthetic designs with potential customers. It turns out that functionality is important to physicians when choosing an electronic medical record. But, they're also pretty passionate about the way the product looks.


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The Free Private Voyeur - Amateur and Voyeur Main Menu - Whats the best free voyeur site
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#161 •
I went on the waiting list at a London dealership about 10 Feb last year. Having been told in the autumn that they expected to know in January when my car would be arriving, I called in last week. I was pleasantly surprised to be told it should be here in February, though they didn't know when. It will be the 2020 model. Now to sort out a charger.


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Anthony Lombardo is a writer and assistant writer on Modern Family.
He along with Daisy Gardner, wrote the episode "Rash Decisions". However this is the only episode he has made up the full story on, of course along with Daisy. He was also credited as an assistant to the writers as part of the miscellaneous crew, he helped write episodes from 2010 to now. He has been credited as Assisitant to Writers, Writers Production Assistant and Production Staff.
This person has no photographs of himself.
Community content is available under CC-BY-SA unless otherwise noted.


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Greensboro Library, NCHome Menu
Idea Collection Event
- Date: 02/25/2019 6:30 PM - 8:00 PM
- Location: McGirt-Horton Branch Library
2501 Phillips Ave.
Greensboro, North Carolina 27405
- CostFree
Participatory Budgeting (PB) Greensboro is a democratic process that allows residents to decide how to spend $500,000 worth of City funds - $100,000 per City Council district. Residents may submit ideas from February 1 to March 31 online. Or come to this Idea Collection Event to learn more and submit your idea!Return to previous page >>
Learn more at PBGreensboro website.
Learn more at PBGreensboro website.


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Certified Housing Counselor specializing in foreclosure prevention.
Certified Credit Counselor National Institute for Financial Education January 6, 2009.
Accredited Credit Counselor Association for Financial Counseling Planning Education July 16, 2010.
Certified Housing Counselor The Association of Housing Counselors March 30, 2012.
Hired as a Client Services Representative, promoted to Credit Counselor then Housing Counselor.
Hired as Customer Assistance Advisor, promoted to Emergency Services, then Sales. Consistently met sales quota, and was recognized at the GM Onstar website for assisting an accident victim.
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New to cruising? Get answers to FAQs ranging from cruise preparation to debarkation. Browse by category or click to see the most popular cruise questions.
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Blue Angels Set to Move to Super Hornets
The US Navy's Blue Angels are tentatively set to start flying the F/A-18 Super Hornet in 2021. The move to the Super Hornet will mark the first time the fighter jet demonstration team has changed aircraft since it moved from the A-4F Skyhawk II to the F/A-18 Hornet in 1986.
McConnell Says, "Russians Are Not Our Friends"
Senate Majority Leader notes alleged meddling in US and European elections and the 2014 annexation of Crimea, saying, "The Russians are not our friends … [they] are acting like the old Soviet Union used to act,"
US Assembles Military Might in Pacific
The US is amassing its military power in the Pacific region.
T-45 Training Grounded Indefinitely
The Navy has extended the grounding of all of its T-45 training jets indefinitely after a group of instructor pilots refused to fly the aircraft. The service's engineers need to figure out what's causing a spike in dangerous physical symptoms in pilots brought on by a drop in oxygen in the cockpit.
Navy Admiral Winter to Lead F-35 Program
RADM Mat Winter has been nominated to lead the Department of Defense's F-35 Lightning II Joint Strike Fighter program office.
Searching the Bay for Sunken Aircraft
The search for sunken aircraft from NAS Patuxent River continues in the Chesapeake Bay.
DefSec: China Building 'Great Wall of Self-Isolation'
Criticizing China's actions in the South China Sea during the Naval Academy commencement address, Carter warned China that it is on a path to build a "great wall of self-isolation."
Good News for Contractors in Defense Bill
There's a lot to like in the procurement reforms in the draft defense bill, even with concerns about some new workplace regulations.
1st Drone Command Center Installed on Carrier
USS Carl Vinson gets first drone command center, the USS Dwight D. Eisenhower, based in Norfolk, VA, is next.
Russian Role in Middle East Expanding Rapidly
Israel is concerned Russian weapons in Syria will reach Hezbollah.


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Tag Archives: recession-proof
Millennials: Make Yourself Recession-Proof [Infographic]
What must young professional to do to get a leg up in the sluggish economy?
As this infographic from MidAmerica Nazarene University shows, the answer is combining a strategically planned education with useful skills, a strong network, and an authoritative voice…
Posted in Career Advice, Gen Y, Infographic Tagged career advice for gen y, generation Y, infographic, Job Search, recession-proof Leave a comment
5 Sure Tips for Kick-Starting Your Independent Career
The second annual State of Independence in America workforce study by MBO Partners* reveals that the independent workforce in the U.S. will grow to 23 million strong in the next five years alone.
3.6 million – or 21 percent – of this workforce is driven by Gen Y.
It's no wonder why: Gen Y faces some formidable challenges when entering today's corporate workforce…
Posted in Career Advice Tagged career advice for millennials, freelance, recession-proof, Shama Kabani, YEC 2 Comments


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Arikara Keyboard - Mobile 4+
The Language Conservancy, Inc.
- Free
Arikara Keyboard - Mobile is the keyboard layout setting for the Arikara language.
(Hello, my relatives! Welcome to you all!)
Arikara Keyboard - Mobile is the iOS setting app that let's you type correct Arikara into any text area on your iOS mobile device by simply switching into the Arikara Keyboard Mobile option.
1. Go to "Settings"
2. Select "General"
3. Select "Keyboard"
4. Select "keyboards"
5. Choose "Add New Keyboard..."
6. Select "MHA Keyboard"
Congratulations! Now you can type Arikara.
Once installed and selected as a keyboard option, you can switch between Arikara and English as you type emails, SMS, MMS, web content, and in any other text-input field. Simply press the GLOBE icon to switch.
This is the ultimate integrated Arikara app keyboard solution to help you type Arikara on Facebook, Twitter or wherever, accurately and with integrity.
This keyboard uses the standard Arikara orthography that is taught in tribal schools around the Great Plains.
Once installed and selected as a keyboard option, you can switch between Arikara and English as you type emails, SMS, MMS, web content, and any other text-input field.
(Here we study Arikara language – it can be done!)
- Seller
- The Language Conservancy, Inc
- Size
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Requires iOS 8.1 or later. Compatible with iPhone, iPad and iPod touch.
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Family Sharing
Up to six family members will be able to use this app with Family Sharing enabled.


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Russians as being a populace are very eager within sports and have excelled in a variety of sports activities. The nation has been a typical feature at the Olympics games procuring high rankings in a very wide number of games. Although as USSR the country had been at its peak during the Olympics, despite the actual split Russia has been able to preserve its position that the Soviets had created.
The Russians have been in all the sports news for their participation in a number of games like soccer, tennis, football, ice hockey, weight-lifting, boxing, gymnastics, skiing, figure skating and volleyball along with a host of various other sports activities.
Basketball developed in the country during the Soviet era. The Russian squad started to acquire several Olympic medals for their capabilities within this game. They are also the current winners in the Eurobasket World Championships having conquered Spain in the final game. They have also been winners of many other European championships such as the Euroleague and the ULEB Cup. They likewise have a player inside the Utah Jazz that is a NBA team.
Ice hockey is certainly another extremely successful sport of the Russians. They have around 30 players that are presently part of the NHL. The players today continue to be maintaining the tradition developed during the Soviet era.
The Russians have taken forth their own successful streak by being in the news for their achievement in the field of ice skating. Having been part of the actual successful team in the Winter Olympics, they also have excelled within ice dancing and pair skating.
Football was one of the most flourishing sports activities during the Soviet era. With the division of USSR came the division of the national football teams as well as clubs. The most important among these was the actual falling apart of the Russian Premier League since it forfeited many of its players. Nevertheless, the game recovered its lost fame and currently features six Premier League teams apart from it now strong national team.
Since the end of the Soviet regime, Russia has grown as a giant in the sport of tennis. A lot of probably the most successful women tennis players originate from this nation along with a few formidable men tennis players too. All these strong Russians have been in the news for their success in the Olympics, Wimbledon, Fed Cup, Davis Cup and several such premier matches.
Chess is another sport which Russians currently have dominated for a very long time having produced a number of world champions and Grand Masters. Another of Russia's popular sports activities would be the Rugby League. The Russians rank 13th amongst all the teams according to the Rugby League International Federation sports news. Rugby Union is one more sport that is quickly gaining popularity between the Russian masses, with the nation standing 17th based on the International Rugby Board.
Among the sports that Russia has received several accolades for is Rhythmic Gymnastics. Together with being one of the most well-liked sports forms in the nation, it has showcased Russia in the world of sports news for owning the earth's best rhythmic gymnasts.


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I'm planning a trip over the Easter weekend, so I'm already counting down the days until I'm on a plane and headed to see my family. But for those of you who aren't checking the calendar every hour or two, here's what you need to know: Easter falls on Sunday, April 12, 2020 ... and the long weekend begins on April 10.
I know that may seem like a ways off, but it's never too early to pick up treats, especially if you're helping the Easter Bunny out this year. And whether you're shopping for the kids or for yourself, you can't go wrong with goodies from LUSH. Their Easter collection is HERE for 2020, and prices start at just $5.95!
A few items are already available online and may be on some store shelves. Select classics are back for another year, like their Dinosaur Egg Bombshell, which is an egg-shaped bath bomb you crack open to reveal a little baby dino. Use one of both halves of the egg at once, and then soak the dinosaur for more bubbles!
As much as I love their surprise bath bombs, I have my eye on the new arrivals. I don't think it really gets any better than this Sunnyside Up Shower Jelly, but that's not the only breakfast-themed treat on the menu. I suppose avocados look a lot like eggs, because this Avo Good Easter Soap is both the perfect pun and the right shape to put inside an Easter basket. It's available online now for $10.95.
LUSH is also teasing a few more items on their website, but they aren't in stock just yet and are still listed as "coming soon." We may see even more goodies arrive between now and April, so I'd pop by your local LUSH or check their website every so often, just in case. Shipping costs vary based on what your order weighs.


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The 2019 NPSL National Championship will feature two familiar foes from the NASL. The New York Cosmos hold a winning edge over Miami FC, with six wins in their nine meetings, with the last match settled between the teams on penalty kicks from after no goals were scored in the The Championship Semifinal on November 5, 2017.
Cosmos forward Aaron Dennis was with Miami for the 2016-17 seasons, and current Miami defender John Neeskens was a fan favorite in Cosmos Country, having won the 2015 NPSL Championship with Cosmos B and returning to play a key role again for the 2018 campaign.
But it is what the two clubs have come to represent that makes this NPSL National Championshipl such an intriguing matchup. The Cosmos claim the richest legacy in North American soccer history while Miami FC began play in 2016. Both clubs share ambitions to grow the game domestically, with aspirations far beyond limitations imposed by current league structures and governance models.
Since their last meeting in the 2017 NASL playoffs, both clubs have not only continued to compete - while some of their peers have suspended play or folded since the NASL saw its divisional sanctioning revoked by U.S. Soccer - they have also refused to subordinate their ambitions with marginalized status in the absence of a unified domestic league structure pyramid with promotion and relegation that is the standard for the global game.
Together with fellow NPSL club Kingston Stockade, Miami FC filed a claim with the Court of Arbitration for Sport in August of 2017, arguing that the absence of promotion and relegation in the current U.S, Soccer Professional League Standards is in violation of FIFA Statute VIII on Sporting Integrity.
Meanwhile Rocco Commisso, Chairman of the New York Cosmos, has taken the lead in the NASL's antitrust lawsuit against U.S. Soccer and Major League Soccer in the Eastern District of New York, vowing, "I am going to fight this until I have my last drop of blood."
Riccardo Silva, President of Miami FC, made a reported $4 billion bid for domestic league soccer media rights in 2017. And in 2018, Commisso, pledged $250 million of his own money as part of a $500 million investment package to enhance the domestic league structure. Both offers of investments to help U.S. Soccer in its mission to make soccer a preeminent sport domestically have been ignored by the national governing body.
The Cosmos and Miami FC have learned the hard way that in the current domestic league sanctioning structure, winning a title will not earn the opportunity to compete an ostensibly higher level of sanctioned play in the next year. The Cosmos repeated as NASL Champions in 2015 and 2016. Miami FC will try to repeat as NPSL Champions in this year's final against the Cosmos.
In other countries, a league title defense could only happen in the top flight. But rising to a higher level of competition by virtue of winning a domestic league title is not allowed by U.S, Soccer at present. So while both clubs seek their second NPSL national title in this year's final, renewing on the pitch competition between two clubs with far-reaching ambitions, both must continue to battle on similar fronts off the pitch to help reform the sport, not only for their own or mutual benefit, but for but the good of the game for all domestically.


text: Editing Termite 0 You do not have permission to edit this page, for the following reasons: The action you have requested is limited to users in one of the groups: Users, FANDOM Staff, FANDOM Helpers, Wiki Managers, Content Team Members. Please log in to edit this wiki.Joining SuperFriends Wiki is free, and it only takes a minute.We hope that you sign in, and become a member of the community!Click here to log in or create an account more + You can view and copy the source of this page: [[File:Termite.jpg|thumb|[[Venusian termites|Alien insects that were biologically similar to Earth '''termites'''.]]<ref>As seen in the [[Super Friends (TV Series)|Superfriends]] [[season 5|season five episode]] ''[[Termites from Venus]]'' (1980).</ref>]] A '''termite''' was a type of [[insect]] that often [[eating|fed]] on [[wood]] and other [[dead]] [[plants|plant materials]]. It was assumed that all [[species]] of '''termites''' were [[Earthling]]s, however since there were also [[Venusian termites|termites]] on [[Venus]], this doesn't seem to be the case. Every [[Earth]] variety of '''termite''' was nothing more than [[animal|dumb animals]], however [[Venusian]] [[Venusian termites|termites]] were at least close to [[Human]]-level [[intelligence]]. Since at least one variety of '''termite''' was [[extraterrestrial]], it's impossible to know for sure where the '''termite''' [[homeworld]] might have been, it could have been [[Earth]] or [[Venus]] or some other [[world]] for that matter. ==[[History]]== ===[[Earth-1A]]=== In [[1980]], a [[species]] of [[alien]] [[Venusian termites|'''termites''']] attempted to [[eating|devour]] much of the [[Earth]]. They were stopped by the [[Super Friends]] and sent into [[space]] toward the [[asteroid belt]].<ref>As seen in the [[Super Friends (TV Series)|Superfriends]] [[season 5|season five episode]] ''[[Termites from Venus]]'' (1980).</ref> ==References== <references/> ==External Link== *[https://en.wikipedia.org/wiki/Termite Termite] at [http://www.wikipedia.org/ Wikipedia] Return to Termite. Retrieved from "https://superfriends.fandom.com/wiki/Termite" Edit summary Preview Mobile Desktop Show changes


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Special baked for coconut lover! You will be surprised with the crispiness and full bodied aroma from the snowy white coconut powder.
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So this is a recent-ish haul. Basically, I spent all my Christmas money on books (with the exception of a purchase from the Hearth and Hand line from Target which is AMAZING by the way. I want it all).
I also purchased The Cruel Prince by Holly Black and The Shining by Stephen King, but those aren't pictured. Together with these other books, I spent $80, so not too shabby.
Let me know if you've read/want to read any of these in the comments below. 🙂


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NIC hands wrestling reins to Michael Sebaaly
Mon., June 3, 2019
North Idaho College athletics director Al Williams announced that Michael Sebaaly has been named the Cardinals' new wrestling coach.
Sebaaly has spent the past five seasons as the head coach at Northwest Kansas Technical College. His team finished No. 3 in the final NJCAA rankings this season and won the National Duals Championship.
"I recognize the expectations are high for the wrestling team at North Idaho College," said Sebaaly. "I take those expectations, which are steeped in the great traditions of this program, seriously. I am honored to be a part of this team and look forward to continuing the program's success, including the popular Tri-State Wrestling Tournament in December and summer wrestling camps."
Sebaaly, who wrestled at the Division I level for the University of Buffalo, spent two years as an assistant coach at Alfred State prior to taking over at NWKTC.
Subscribe to the sports newsletter
Get the day's top sports headlines and breaking news delivered to your inbox by subscribing here.


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|Transformation (r)Evolution
24 March 2009
Sofitel Brussels Europe
The Finance Transformation Leaders Conference will be held in Brussels at the Sofitel Brussels Europe Hotel*. Upon receipt of registration, we will provide our preferential booking form at the Sofitel Brussels Europe, valid until Monday 23 February, to be sent to the hotel directly. After 23 February, the preferential rate will be available upon availability at the hotel only.
|Sofitel Brussels Europe
Address Get directions
Place Jourdan 1
1040 Brussels
Telephone: +32 2 235 5100
Fax: +32 2 235 5101
Email: email@example.com
Website: www.sofitel.com
|Alternative Accommodation
The following hotels are a short walk from the conference venue:
Other hotels close to the conference can be found at www.hrs.com
* You are responsible for your own hotel and travel arrangements.
|Premium Sponsors


text:
Program Details
A Master of Professional Studies degree in Enterprise Intelligence is available online with Northeastern University. This multidisciplinary curriculum supplies well-rounded information to students interested in data, technology, and human literacy. Enterprise intelligence is a high-demand field, requiring professionals with advanced problem-solving, leadership, and analytical skills.
Studies include artificial intelligence, data management and big data, AI system technologies, and more. Students work closely with faculty from different fields of expertise. Prepare yourself with an advanced degree in an evolving world of technology through NU online, and become a competitive contender in today's marketplace.
- Bachelor's degree
- Statement of purpose
- Professional resume
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School Accreditation Statement
New England Commission of Higher Education


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I'm barely old enough to remember a time when mass shootings united our country in sorrow and spurred the press to serious investigation. These days, it seems like each tragedy becomes another excuse to attack Donald Trump.
That's certainly what happened when my sister Meadow was murdered in Parkland. My dad, Andrew Pollack, and I wanted the facts. But when we demanded to know what went wrong and why, Broward School Superintendent Robert Runcie dismissed our concerns as right wing "fake news," and most of the media focused more on attacking questions rather than answering them.
That left it to us to find answers. After a year of investigating, we've written a book that exposes every failure and tells parents the profound national significance of what happened here: "Why Meadow Died: The People and Policies that Created the Parkland Shooter and Endanger America's Students."
Every parent and teacher in America needs to know the untold story of Parkland. Because it was the most avoidable mass murder in American history, and the policies that made it inevitable have spread to your school.
The shooter could not possibly have been more clear that he wanted to murder. In middle school, he talked about guns almost every day. Everyone was terrified of him. A teacher said that she thought he was a serious danger because he couldn't tell the difference between violent video games and reality. When they finally transferred him to a specialized school for disturbed students, he told staff there that he dreamt of killing and being covered in blood.
Then, after a few months of good behavior, they put him in Marjory Stoneman Douglas (MSD) High School next to my sister. Not only that, I guess because he liked guns so much, they let him practice shooting in JROTC.
At MSD, he was brought to the office all of the time. He allegedly threatened to kill other students, carved swastikas into a lunchroom table, and wrote racist slurs his backpack. He scared them so much that they prohibited him from wearing a backpack and frisked him every day to be sure he wasn't carrying a deadly weapon.
But you wouldn't know it from his official educational records. And that's hardly surprising. Under the leadership of Superintendent Runcie, Broward became ground zero for a dangerous new approach to school safety. In an effort to fight the so-called "school to prison pipeline" and implement "restorative justice" Runcie pressured schools to dramatically lower suspensions, expulsions, and arrests. And principals responded by refusing to enforce rules or document deeply disturbing behavior.
This matters far beyond Parkland, because these politically correct leniency policies have spread across America. Before coming to Broward, Runcie worked under Arne Duncan when he was Superintendent of Chicago Public Schools. As President Obama's Secretary of Education, Duncan used federal civil rights investigations, and the threat thereof, to coerce hundreds of school districts serving millions of students to adopt Runcie's leniency policies.
Nationwide, 70 percent of teachers say that their schools decreased suspensions by having a higher tolerance for misbehavior, and almost half say that the apparent decrease in discipline was due to under-reporting. Only a quarter of teachers say that their principals consistently report serious incidents.
These policies are everywhere. Usually they just lead to rampant disorder, bullying, and violence. But sometimes the consequences are far more severe. Look at what happened in Dayton: the shooter was caught with a kill list and a rape list but had nothing on his record to stop him from buying a gun. He was suspended for a bit, then put back into school, leaving students so scared that a third of them skipped school.
Parents have to wake up. My dad and I fought tooth and nail to expose these policies, and the families of all of the victims united to ask Broward County to vote for new school board members. But Broward didn't care to look at the facts or change anything.
Fortunately, President Trump looked at the facts. His Federal School Safety Commission ended the Department of Education initiative that pressured schools to adopt these policies. But nothing will change unless parents take action at the local level.
A few years ago, America had a national grassroots uprising against the Common Core, which the Obama administration also pushed into our schools without parents' knowledge or teachers' consent. But concerned mothers and fathers fought hard to uproot it.
This is what must happen now with these "restorative justice" policies. We hope that Meadow's death won't go down in history as just another excuse to attack Donald Trump. Rather, we hope that parents across America will take the time to learn the true story of Parkland, and take action to #fixit and make school safe again.
Hunter Pollack (@PollackHunter) lost his sister, Meadow, in the Parkland school shooting. He is a school safety activist, and wrote the foreword to "Why Meadow Died: The People and Policies that Created the Parkland Shooter and Endanger America's Students."
The views and opinions expressed in this commentary are those of the author and do not reflect the official position of The Daily Caller.


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About that "Tebowing"
Originally Published in The Denver Post English is rapidly changing in our fast-paced media world. Nouns are becoming verbs and sometimes adjectives are becoming nouns. The most recent and popular of these changes surrounds today's NFL playoff game between the Denver Broncos and the New England Patriots. The hype around
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Monday marks the 26th anniversary of the first observance of Martin Luther King Jr. Day. While we commemorate the sacrifices this great leader made, Americans, including Muslim Americans, must remember the spirit of change that the civil rights movement embodied. The same spirit is required today to change the false
Boko Haram terrorist acts condemnable
Originally Published in The Columbus Dispatch Boko Haram, a Nigerian militant group that claims to be Muslim claimed responsibility for several church bombings around the time of Christmas. This is the same extremist group that killed dozens of innocent Christians on the New Years bombings last year. Such inhumane acts cannot
Lowe's: 'Let's Build a Prejudiced America?'
Originally Published in The Record The world's second largest hardware chain, Lowe's, is ranked among the Top 50 corporations in America. Its website proudly displays the slogan "Let's Build Something Together." However, the company's recent actions suggest that this togetherness might not include Muslim-Americans. The company recently pulled its ads
Pakistan's Failed Commitment: How Pakistan's Institutionalized Persecution Of The Ahmadiyya Muslim Community Violates The International Covenant On Civil And Political Rights
By Qasim Rashid* "My guiding principle will be justice and complete impartiality, and I am sure that with your support and cooperation, I can look forward to Pakistan becoming one of the greatest Nations of the world." – Muhammad Ali Jinnah, Pakistan's Founder and First Governor General at the Presidential Address to
An Ahmadi Muslim's Plea: Be My Voice
Religious freedom (or the lack thereof) in Pakistan cannot be emphasized enough. Due to the preposterous demeanor of Pakistan's self-righteous right-wing, many in the world today are aware of Pakistan's notorious blasphemy problem. Much frustration has been expressed on liberal Pakistani blogs and through international media outlets — especially after
Waging The Jihad of The Pen
Originally Published in The Huffington Post Sardar Anees Ahmad remembers exactly where he was when the second plane struck on 9/11: obliviously walking with his professor, going from one class to another at his college in New York. As the tragedy unfolded, and one after another, a Muslim face and name
How Muslims Honor 9/11
Originally Appeared on The Huffington Post "First you bomb us and now you come suck our blood. What are you gonna do with it, drink it?" These were the words of a young man as he passed by me at the Labor Day Fair in Rutherford, N.J. I was passing
Misuse And Abuse Of Legal Argument By Analogy In Transjudicial Communication: The Case Of Zaheeruddin V. State
ABSTRACT: This article explores the risks and limits of transjudicial communication. In particular, I critique the scholarly contention that transjudicial communication can be built upon commonly accepted methods of legal reasoning. I argue that transnational courts do not uniformly understand or apply commonly accepted methods of legal reasoning, especially legal
How Pakistan Drifted Away from Itself
Originally Appeared on The Huffington Post With the partition of the Indian subcontinent, the Dominion of Pakistan came into existence on Aug. 14, 1947. The valiant and astute Muhammad Ali Jinnah led the minority Muslim community of United India to the fulfillment of its dream for a separate homeland. The basis


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BOSTON, June 2, 2020 /PRNewswire/ -- River and Mercantile (R&M) announced that Michael Clark, Managing Director and Consulting Actuary, is the 2020 recipient of the Geoffrey Heywood award. Given by the International Association of Consulting Actuaries (IACA), a section of the International Actuarial Association which is the worldwide association of professional actuarial associations, the award recognizes a young consulting actuary for their significant contributions to the public and actuarial profession.
Awarded every two years, the intent of this recognition is to bring to the consulting actuarial profession into the public domain and to encourage the successful development of consulting actuarial practices and actuarial literature.
Mr. Clark, who heads River and Mercantile's operations in the west as well as business development for the US Solutions business, also serves as the President of the Conference of Consulting Actuaries (CCA). A sought-after speaker and expert on pension related issues, he is experienced in all aspects of financial risk management for defined benefit plans as well as retiree medical plans and defined contribution plans.
"I am proud to be the recipient of this high honor and take great pride in the important work of promoting the profession, highlighting the critical contributions actuaries make on the business world and society at large," commented Clark.
"Michael has an immense passion for sharing knowledge. He is a go-to source for issues relating to retirement plans and risk management strategies and serves as a mentor for the next generation of leaders in our profession," said Tom Cassara, Managing Director and head of River and Mercantile's US business. "We wholeheartedly congratulate Michael on this great accomplishment."
Mr. Clark is a frequent contributor and speaker at industry and professional association conferences on the topics of pension risk management and pension plan administration and has had several articles published in major trade magazines. Additionally, he participates in the leadership of the Western Pension & Benefits Council ? Denver Chapter. He is a Fellow of the Conference of Consulting Actuaries, a Fellow of the Society of Actuaries, an Enrolled Actuary, and a Member of the American Academy of Actuaries.
About River and Mercantile (R&M)
River and Mercantile (R&M) provides investment consulting, actuarial consulting and fiduciary investment management services to institutional investors. The firm provides services to defined benefit and defined contribution retirement plans, insurance companies, insurance captives, endowments, and foundations. Please visit www.riverandmercantile.us/solutions/ for more information.
SOURCE River and Mercantile (R&M)
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Ph 1B B-701 in Combination With Pembrolizumab in Metastatic Transitional Cell Carcinoma of the Urothelial Tract
This research study is studying a combination of two experimental drugs as a possible treatment for Bladder Cancer that recurred after treatment with standard therapy, or Bladder Cancer that got worse while on treatment with standard therapy.
The following interventions will be involved in this study:
- Pembrolizumab
Full Title of Study: "A Phase 1B Study of B-701 in Combination With Pembrolizumab in Relapsed or Refractory Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelial Tract"
Study Type
- Study Type: Interventional
- Study Design
- Allocation: N/A
- Intervention Model: Single Group Assignment
- Primary Purpose: Treatment
- Masking: None (Open Label)
- Study Primary Completion Date: June 2017
Detailed Description
This research study is a Phase I clinical trial, which tests the safety of an investigational intervention and also tries to define the appropriate dose of the investigational intervention to use for further studies. "Investigational" means that the intervention is being studied.
The FDA (the U.S. Food and Drug Administration) has not approved B-701 as a treatment for any disease.
The FDA has not approved Pembrolizumab for Bladder Cancer but it has been approved for other uses.
This is the first time that B-701 in combination with Pembrolizumab will be given to humans.
In this research study, Investigators are…
- Testing the effectiveness and safety of the combination of two experimental drugs (B-701 and Pembrolizumab);
- Learning about the good and/or bad effects the drugs have on participants and their cancer;
- Administering B-701 and Pembrolizumab, which are antibodies (proteins that bind to other molecules), because…
- B-701 binds to a protein receptor called FGFR3 (fibroblast growth factor receptor 3). FGFR3 has been found to be present (expressed) or changed (mutated) on the surface of in many types of cancer cells. Targeting FGFR3 may inhibit cancer growth.
- Pembrolizumab binds to a protein cell surface receptor called PD-1, which is found on certain types of lymphocytes and which are also involved in many types of cancer;
- Treating participants with Pembrolizumab, which is approved by the FDA for the treatment of Metastatic Melanoma, a Cancer of the skin;
- Collecting blood and tissue samples and other related medical information to learn more about the development of cancer and predictors of response;
- And hoping to learn how the combination of study drugs work in the treatment of cancer to help develop new treatments.
- Drug: B-701
- B-701 is a phage-derived, affinity-matured, human monoclonal antibody (mAb) specific for FGFR3. It is based on a human immunoglobulin G1 (IgG1) framework containing heavy chain VHIII and light chain VκI subgroup sequences.
- Drug: Pembrolizumab
- Pembrolizumab is an mAb that binds to the programmed cell death protein 1 (PD-1) receptor and blocks its interaction with programmed death-ligand 1 (PD-L1) and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response. In syngeneic mouse tumor models, blocking PD-1 activity resulted in decreased tumor growth.
Arms, Groups and Cohorts
- Experimental: B-701 and Pembrolizumab
- B-701 will be administered every 3 weeks intravenously Pembrolizumab will be administered every 3 weeks intravenously
Clinical Trial Outcome Measures
Primary Measures
- Preliminarily Evaluate The Safety Of B-701 In Combination With Pembrolizumab For The Treatment Of TCC
- Time Frame: 2 years
- Safety will be assessed through summaries of AEs (adverse events), changes in laboratory test results, ECGs (electrocardiograms), and changes in vital signs
Secondary Measures
- To Assess The Efficacy Of B-701 In Combination With Pembrolizumab For The Treatment Of TCC
- Time Frame: 2 years
- Measured by RECIST-based assessment of response and progression
Participating in This Clinical Trial
Inclusion Criteria
- Participants must have Stage IV, locally advanced or metastatic (T4b, any N; or any T, N2-3) urothelial bladder cancer or transitional cell carcinoma (TCC) arising in another location of the urinary tract, including urethra, ureter, and renal pelvis. The diagnosis must be histologically or cytologically confirmed. Mixed histologies are permitted as long as TCC is the major component (i.e. > 50% of the pathologic specimen). Pure or predominant squamous cell carcinomas or adenocarcinomas are not permitted.
- Relapsed after or refractory to one or two prior lines of chemotherapy for advanced or metastatic/recurrent disease (at least one cycle each) which have not included a PD-L1 or FGFR inhibitor. At least one regimen should have included a platinum agent unless contraindicated for the subject. Prior neoadjuvant or adjuvant chemotherapy (without a PD-L1 or FGFR inhibitor) is permitted and will not be counted as first-line chemotherapy, as long as the subject has not progressed within 12 months of the last dose. However, a regimen of neoadjuvant or adjuvant chemotherapy will be counted as first-line chemotherapy if the patient progressed within 12 months of the last dose.
- Age ≥ 18 years
- Eastern cooperative oncology group (ECOG) performance status ≤ 1 (Karnofsky ≥ 60%)
- Participants must have normal organ and marrow function as defined below:
- leukocytes ≥ 3000/mcL
- absolute neutrophil count ≥ 1500/mcL
- platelets ≥ 75,000/mcL
- hemoglobin ≥ 9 g/dL or ≥ 5.6 mmol/L
- total bilirubin within normal institutional limits
- EXCEPTION: Subjects with known Gilbert's disease: total bilirubin ≤ 3 × institutional upper limit of normal (ULN)
- aspartate aminotransferase (AST) or serum glutamic oxaloacetic transaminase (SGOT)/Alanine aminotransferase (ALT) serum glutamic pyruvic transaminase (SGPT) ≤ 2.5 × institutional ULN
- EXCEPTION: Subjects with documented liver metastases: AST and/or ALT ≤ 5 × institutional ULN
- creatinine within normal institutional limits OR
- creatinine clearance ≥ 60 mL/min/1.73 m2 for participants with creatinine levels above institutional normal (derived by the Cockcroft-Gault formula [Cockcroft 1976])
- albumin ≥ 2.5 mg/dL
- prothrombin time/international normalized ratio (PT/INR) and partial thromboplastin time (PTT) ≤ 1.5 × institutional ULN
- Note: Screening labs should be performed within 10 days of treatment initiation.
- Absence of any psychological, familial, sociological, or geographical condition potentially hampering compliance with the study protocol and follow-up schedule (such conditions should be discussed with the subject before study entry)
- The effects of B-701 on the developing human fetus are unknown. For this reason and because PD-1 inhibitors such as pembrolizumab may potentially cause fetal harm, women of child-bearing potential (defined as those who have not been surgically sterilized or have not been free from menses for > 1 year) and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. Men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and 4 months after completion of study drug administration.
- Female of childbearing potential should have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medications. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.
- Female of childbearing potential must be willing to use 2 methods of birth control or be surgically sterile, or abstain from heterosexual activity for the course of the study and through 4 months after the last dose of study medication.
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria
- Participants who have had chemotherapy, targeted small molecule therapy, or radiotherapy within 2 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 2 weeks earlier.
- Participants who are receiving, or have received, any other investigational drugs or devices within the 2 weeks prior to the first dose of study medications.
- Participants who received major surgery must be recovered adequately from the toxicity and/or complications from the interventions prior to starting therapy.
- Participants with a diagnosis of immunodeficiency or who are receiving systemic steroid therapy (>5 mg prednisone or its equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of study treatment.
- Participants who have a primary central nervous system (CNS) malignancy, or untreated/active CNS metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control). Individuals with a history of treated CNS metastases are eligible, provided they meet all of the following criteria:
- Evaluable or measurable disease outside the CNS
- Radiographic demonstration of stability upon the completion of CNS directed therapy and no evidence of interim progression (for at least 4 weeks prior to the first dose of study drug) between the completion of CNS-directed therapy and the screening radiographic procedure
- The screening CNS radiographic procedure is ≥ 8 weeks since completion of radiotherapy and ≥ 4 weeks since the discontinuation of corticosteroids and anticonvulsants Note: These exceptions do not include carcinomatous meningitis which is excluded regardless of clinical stability.
- Participants with a history of allergic reactions attributed to monoclonal antibody therapy (or recombinant antibody-related fusion proteins)
- Participants with active autoimmune disease that has required systemic treatment (>5 mg of prednisone or its equivalent) in the past 2 years (i.e. with use of disease modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment.
- Participants with known evidence of active, non-infectious pneumonitis.
- Participants with an active infection requiring systemic therapy.
- Participants who have received a live vaccine within 30 days of planned start of study therapy.
Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowed.
- Participants who have had a prior anti-cancer monoclonal antibody (mAb) within 2 weeks prior to Cycle 1 Day 1 or who have not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to agents administered more than 2 weeks earlier.
- Participants unwilling or unable to discontinue use of prohibited therapies, including any cytotoxic chemotherapy, radiotherapy, immunotherapy or biologic agent (approved or investigational) for the treatment of TCC are ineligible.
- Participants with uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- Participants who have undergone a major surgical procedure or trauma within 4 weeks prior to Cycle 1, Day 1. All wounds must be fully healed on Cycle 1, Day 1
- Participants with a history of other malignancy which could affect compliance with the protocol or interpretation of results. Individuals with a history of curatively treated basal or squamous cell carcinoma of the skin or in situ carcinoma of the cervix are allowed. Participants with a malignancy that has been treated with curative intent will also be allowed if the malignancy has been in remission without treatment for ≥ 2 years prior to Cycle 1, Day 1.
- Pregnant women are excluded from this study because the risks with B-701 are unknown and pembrolizumab is a PD-1 inhibitor with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with B-701 and pembrolizumab, breastfeeding should be discontinued. Women of child-bearing potential must agree to use adequate birth control throughout the study duration.
- Hepatitis B, hepatitis C, and HIV serology-positive (or known history of HIV seropositive status) participants are ineligible because these underlying diseases will confound interpretation of important safety assessments, e.g. liver function tests, increased potential for reactivation or exacerbation of viral infections. Such individuals may be taking or require other drugs, and may be at higher risk of opportunistic infections and adverse effects. Hepatitis B, hepatitis C, and HIV serology-positive individuals were excluded from the pivotal pembrolizumab clinical trial in melanoma, so safety of this drug in this setting is unknown.
- Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection (excluding fungal infections of nail beds) at screening or any major episode of infection requiring treatment with IV antibiotics or hospitalization (relating to the completion of the course of antibiotics) within 4 weeks prior to Cycle 1, Day 1
- Has a known history of active TB (Bacillus Tuberculosis)
- Participants who weigh > 110 kg will be ineligible due to study drug limitations
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 18 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Mark Pomerantz, MD
- Collaborator
- Merck Sharp & Dohme Corp.
- Provider of Information About this Clinical Study
- Sponsor-Investigator: Mark Pomerantz, MD, Assistant Professor of Medicine, Harvard Medical School – Dana-Farber Cancer Institute
- Overall Official(s)
- Mark Pomerantz, MD, Principal Investigator, Dana-Farber Cancer Institute
Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.


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Switching gears from Coffee to Music, I'm happy to welcome Barry Kerch (Shinedown) to the first addition of the "Music Cast".
In this episode we break down touring in 2019, balancing mental health and addiction issues within the band, his coffee brand "Spartan Brews" and so much more. It's a super informative chat and a crucial commentary as to some of the struggles within the music industry.
Shinedown have sold millions of Albums around the world, are from Jacksonville, Florida and are on Tour with Alterbridge in Europe this fall in support of their latest album; "Attention, Attention"
As always, pour a cup, settle in and learn a thing or two! Visit the Podcasts above or click Here To Listen!


text:
Make BackgroundHTMLParser track line/column numbers
Created attachment 184010 [details]
Comment on attachment 184010 [details]
View in context: https://bugs.webkit.org/attachment.cgi?id=184010&action=review
> Source/WebCore/html/parser/BackgroundHTMLParser.cpp:128
> + m_pendingTokens.append(CompactHTMLToken(m_token, TextPosition(m_input.current().currentLine(), m_input.current().currentColumn())));
That's unfortunate. I guess tokens are less compact now. :)
I guess we need lines for each token to handle event handler lines properly?
This is going to conflict with bug 107317.
I think we're also probably going to change compact token to just carry the deltas from the previous token. Those will take up less than 32-bits each, and allow compact token to be smaller again.
Then we would send the real line number separately in the "Delivery" object, and only the deltas in each token. That means that if for some reason we ever got off, we'd only be off for at max tokenLimit tokens.
Comment on attachment 184010 [details]
Rejecting attachment 184010 [details] from commit-queue.
Failed to run "['/mnt/git/webkit-commit-queue/Tools/Scripts/webkit-patch', '--status-host=queues.webkit.org', '-..." exit_code: 2 cwd: /mnt/git/webkit-commit-queue
Last 500 characters of output:
rce/WebKit/chromium/webkit/media/crypto/ppapi/cdm --revision 173055 --non-interactive --force --accept theirs-conflict --ignore-externals' in '/mnt/git/webkit-commit-queue/Source/WebKit/chromium'
56>At revision 173055.
________ running '/usr/bin/python tools/clang/scripts/update.py --mac-only' in '/mnt/git/webkit-commit-queue/Source/WebKit/chromium'
________ running '/usr/bin/python gyp_webkit' in '/mnt/git/webkit-commit-queue/Source/WebKit/chromium'
Updating webkit projects from gyp files...
Full output: http://queues.webkit.org/results/16043681
The question of where to draw the line between line number accuracy and parser speed is a separate one we can solve after this.
If we only stored per-token-deltas, then we could yield after any token where the delta would be too large. (trading speed for accuracy) or simply ignore the error, or use a solution like you did (which trades some potential speed for accuracy on all documents).
I'll follow-up with a separate bug after we get perf data.
Created attachment 184033 [details]
Patch for landing
Comment on attachment 184033 [details]
Patch for landing
Rejecting attachment 184033 [details] from commit-queue.
Failed to run "['/mnt/git/webkit-commit-queue/Tools/Scripts/webkit-patch', '--status-host=queues.webkit.org', '-..." exit_code: 2 cwd: /mnt/git/webkit-commit-queue
Last 500 characters of output:
z 2 (offset 8 lines).
patching file Source/WebCore/html/parser/CompactHTMLToken.h
Hunk #3 succeeded at 65 with fuzz 2.
Hunk #4 FAILED at 75.
1 out of 4 hunks FAILED -- saving rejects to file Source/WebCore/html/parser/CompactHTMLToken.h.rej
patching file Source/WebCore/html/parser/HTMLDocumentParser.cpp
patching file Source/WebCore/html/parser/HTMLDocumentParser.h
Failed to run "[u'/mnt/git/webkit-commit-queue/Tools/Scripts/svn-apply', '--force']" exit_code: 1 cwd: /mnt/git/webkit-commit-queue
Full output: http://queues.webkit.org/results/16044730
It appears my patch won the commit-queue race. :(
We'll need to add this to "SameSizeAsCompactToken", which I can do if you'd like:
Created attachment 184041 [details]
Patch for landing
Comment on attachment 184041 [details]
Patch for landing
Clearing flags on attachment: 184041
Committed r140467: <http://trac.webkit.org/changeset/140467>
All reviewed patches have been landed. Closing bug.