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Trade policies and practices by measure introduction
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Measures Directly Affecting Imports
Preshipment inspection
India WT/TPR/S/249
During the period under review, India continued to streamline customs procedures and implement trade facilitation measures. An electronic system for customs clearance has been introduced, and a risk management system is also in place to selectively screen high and medium risk cargo for customs examination. Despite these measures, India's import regime remains complex, especially its licensing and permit system, and its tariff structure, which has multiple exemptions that vary according to product, user, or specific export promotion programme.
India's tariff is announced in the annual Budget but individual tariff rates may be changed during the year. In addition to the standard tariff rate, importers are required to pay an additional duty ("countervailing duty") and a special additional duty instead of local taxes. To determine the "effective" applied tariff rate (i.e. basic duties and other customs duty) on a particular product, separate customs and excise tax schedules must be consulted, which adds to the complexity of the tariff. India's
tariff comprises mainly
ad valorem
rates (some 94% of tariff lines), levied on the c.i.f. value of imports; and some alternate or specific duties (6.1% of all tariff lines). During the period under review, the average tariff rate declined: the simple average applied MFN tariff was 12% in 2010/11, down from 15.1% in 2006/07. This is reflected in a decrease in both agricultural and industrial average tariffs due to India's shift towards lower tariffs.
Import restrictions may be imposed on grounds of,
inter alia
, health, safety, moral, and security reasons, and for self‑sufficiency and balance‑of‑payments reasons. India links the use of import restrictions and licensing, and other non‑tariff measures (NTMs) to domestic policies; for example, NTMs are relaxed when imports are necessary to alleviate inflation or shortages. State trading is also used as a policy tool, to ensure,
inter alia
, a "fair" return to farmers,
food security
, the supply of fertilizer to farmers, and the functioning of domestic support price systems. India is one of the most active users of anti-dumping measures among WTO Members. Since its last Review in 2007, India has also imposed several safeguard measures. As a result of an amendment of the legislation as of 2010, safeguard measures may also take the form of quantitative restrictions.
As in the case of imports, export prohibitions and restrictions are mainly in place to ensure domestic supply of specific goods and thus may be removed and applied as the circumstances require. In order to reduce the anti-export bias inherent in India's import and indirect tax regime, a number of duty remission and exemption schemes are in place to facilitate exports. Tax holidays are also available to investors through the export‑processing zones and export‑oriented units.
India grants direct and indirect assistance to various sectors. Most central government subsidies are destined for agriculture. Other key subsidies include those for diesel and fertilizers. The states provide additional subsidies, especially for basic services such as education and health, and electricity and water. Price controls apply to some commodities and are used as a means to provide subsidies to farmers and a population under the poverty line, and to ensure a "reasonable price" for quality drugs.
Since its last Review, India has made several amendments to its main competition policy legislation and the Competition Commission of India (CCI) created under the Competition Act 2002 started operations in 2009. In addition, some aspects of the law affecting mergers and acquisitions recently entered into force. India became an observer to the WTO Agreement on Government Procurement in February 2010. Its procurement system continues to be decentralized, comprising a multiplicity of entities at different levels of Government (including numerous central public‑sector enterprises), and no common legislation governing procurement. Public procurement is considered as an important instrument of government policy and is used to obtain certain socio‑economic objectives. As a result, the Central Government has set reservations and price preferences as part of the procurement system. However, competition from foreign suppliers is ordinarily allowed.
India has made improvements in IPR enforcement through
increased border protection
, and its IP offices continued to pursue promising modernization efforts.
Measures Directly Affecting Imports
Customs procedures
Registration and documentation
Since its last Trade Policy Review in 2007, India has continued the process of changing to paperless, electronic customs clearance. Importers (Indians and foreign nationals), with a few exceptions, must register with the Directorate General of Foreign Trade (DGFT) and obtain an importer‑exporter code (IEC) number to be able to import commercially (Table AIII.1).
Since 2007, registration has been online, through application and provision of supporting documents (e.g. bank certificate and income tax permanent number).
India has six regimes for entry of imports: (a) imports for home consumption; (b) warehousing; (c) transhipment; (d) transit; (e) re‑importation; and (f) imports for special economic zones (SEZs). For home consumption, importers may clear goods after payment of the duties and charges, or for warehousing without immediate payment of duties. Imports cleared for warehousing
require a bill of entry
, filed with all supporting documents as required for goods for home consumption. The duty payable is determined by Customs. Duties are not paid at the time of warehousing but at the time of the ex‑bond clearance, for which an ex‑bond bill of entry is filed. The final duty rate is determined when an import declaration is presented for warehoused goods to be imported into the domestic tariff area (DTA). Warehoused goods may be moved from one warehouse to another without payment of taxes (included inter‑state taxes). Inter‑state tax would be payable only if the movement from one warehouse to another entailed an inter‑state sale: in this case, the transaction would be subject to sales tax, entry tax (charged by some states
), and octroi if goods are sold to a warehouse located in the State of Maharashtra. In general, transhipment of containers at Indian ports is allowed without any examination by Customs. Transhipped good require a transhipment bill of lading.
Transit of goods through India is allowed without payment of duty and without examination by Customs, except if customs officials are informed of the possibility of illegal trade. Goods exported from India may be re‑imported within three years but there must be no change in the classification of the goods. Re‑imported goods are subject to duties, except goods exported for repairs abroad
, for exhibitions, or as samples, which may be re‑imported duty free. Special economic zones (SEZs) are deemed foreign territory for trade operations. Imports into SEZs
enter without payment of taxes
, duties or cess. They are not subject to customs examination at the port; any required examination will take place at the zone.
To clear goods for home consumption, importers must file a bill of entry, which may be processed manually or through the electronic data interchange (EDI) system. Supporting documents (e.g. invoice, packing list, and bill of lading/airway bill) must be filed along with the bill of entry if it is processed manually. Import licences from the DGFT, and sanitary and phytosanitary certificates from the Ministry of Agriculture must be obtained prior to importation and submitted along with the customs declaration. Additional documentation may also be required (e.g. a country of origin certificate) for goods imported under a preferential trade agreement or under an export incentive scheme and qualifying for duty reductions (section (iv)(e) and (3)(vii)(c)).
The bill of entry may be filed prior to the arrival of the goods to allow for faster clearance, but no earlier than 30 days before the arrival date of the vessel or aircraft carrying the goods.
Importers that use the EDI system to clear imports are required to file a bill of entry in electronic format containing all the relevant information; the supporting documents must be submitted when imports undergo physical examination. EDI facilities are available at 92 customs offices.
About 97.5% of all import documents are processed electronically; about 0.67 million registered IEC holders use EDI facilities.
In 2005, India introduced a risk management system (RMS) as a measure of trade facilitation to selectively screen only high and medium risk cargo for customs examination. The RMS consolidated the "green channel" clearance facility and other fast‑track facilities to clear goods. The RMS for processing imports is operational at 48 customs offices; some 85% of India's imports are processed via this system. In addition, importers with a good track record and complying
with qualifying criteria
, are entitled to be accredited for special clearance procedures under the Accredited Client's Programme (ACP).
As at early 2011, 250 ACP importers are allowed to self‑assess their consignments with no need for examination, in line with India's commitments to simplify and harmonize Customs' procedures under the revised Kyoto Convention.
Under the RMS, importers file an electronic bill of entry and the system indicates which import certificates, permits, or licences are required. The RMS reviews the documents and provides one of four possible instructions for both ACP (if cargo is considered risky) and non‑ACP importers: (a) imports may be discharged without further assessment (i.e. of their classification, rate of duty or valuation) or examination; (b) imports may be cleared with no further assessment but subject to examination; (c) the release of imports requires further assessment but no examination; or (d) imports must be assessed and examined.
Certificates of registration and import permits (e.g. certificates of origin, sanitary and phytosanitary certificates, and end‑use certificates) issued by different agencies, are required to import specific goods,
in certain instances
, depending on their end‑use.
These certificates must be submitted at the time of filing the bill of entry. Under the Insecticides Act 1968, products that are included in the Schedule to the Act, that have not been registered in India as insecticides, must be imported on the basis of import permit or end‑use (no‑objection) certificate for products used for non‑insecticidal purpose (section (x)). For instance, imports of boric acid for insecticidal use must be registered with the Central Insecticides Board and Registration Committee (CIB & RC)
, as well as an import permit issued by the CIB & RC.
However, in the case of imports of non‑insecticidal boric acid the administrative ministry concerned (e.g. Ministry of Agriculture) also has to issue an end‑use (no‑objection) certificate prior to the importation, to regulate its use.
Without the no‑objection certificate, which is issued only to end‑users and not to importers in general, imports are not allowed.
If these requirements are not fulfilled, imports are confiscated and the importer may be fined and/or imprisoned; these measures are aimed at protecting public health.
For imports under duty exemptions and free‑trade zones schemes (section (3)(vii)), importers are required to "execute" a bond with Customs. The bond is equal to the amount of payable duty on the imported goods. If importers fail to fulfil the bond conditions, usually related to the fulfilment of post‑importation conditions, they must pay the duty levied on these imports along with interest rates at the applicable rate.
Customs clearance has been more efficient since 2007:
on average
, import procedures are completed in 20 days (41 days in 2007), including 8 days for document preparation and 4 days for customs clearance and technical inspections. The cost per container is US$960, including preparing documents (US$390) and clearing customs (US$120).
The implementation of the EDI system in 1994
, and the RMS in 2005 at India's major customs offices, has helped to render border procedures more efficient. EDI facilities have been extended to 92 locations and all major customs ports. The number of documents processed through the EDI increased from 3.2 million in 2008/09 to 8 million in 2010/11 (as at December 2010).
If an importer is not satisfied with the assessment (i.e. the classification, rate of duty or valuation) by the customs officer, the importer may appeal against the "assessment order" (i.e. a decision made in writing by an officer). No data is collected on the number of appeals against "assessment orders".
Preshipment inspection
Preshipment inspection for imports of certain goods has been mandatory since 2004. Goods subject to preshipment inspection include unshredded metallic waste and scrap (since 2004), and shredded metallic waste and scrap (since 2009) (Table III.1).
Imports of unshredded metallic waste and scrap are permitted through 26 designated ports. Inspections ensure that consignments are free of arms, explosives, and radioactive‑contaminated materials.
Preshipment inspection certificates are issued by accredited certifying agencies located inside and outside India.
Table III.1
Metallic waste and scrap subject to preshipment inspection, 2011
ITC code
Waste and scrap of cast iron
Of high speed steel
Waste and scrap of tinned iron or steel
, chips, milling waste, saw dust, fillings, trimmings and stampings, whether or not in bundles
Remelting scrap ingots
Copper scrap
Brass scrap
Nickel scrap
Aluminium scrap
Zinc scrap
Tin scrap
Magnesium scrap
Department of Commerce (2010),
Handbook of Procedures 2009‑2014
, Vol. I, incorporating Annual Supplement, 23 August. Viewed at: http://dgft.gov. in.
Imports of certain types of second‑hand and defective steel products, as well as textiles and clothing articles are subject to preshipment inspection on safety and health grounds.
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Amino derivatives, method for the inhibition of the synthesis of nitric oxide, a method of selective inhibition of the synthesis of nitric oxide produced by inducible no-synthase, the method of reducing levels of nitric oxide, a pharmaceutical composition
(57) Abstract:The invention relates to new derivatives of formula (I), where R1- R4- hydrogen atoms; X - alkylene with 1 to 6 carbon atoms; Y is lower alkyl; B is - NR5R11where R5is a hydrogen atom, R11selected from 5 - to 6-membered heterocyclic radical, in which one ring member is a carbon and 1 to 4 members of the heteroatoms nitrogen, or sulfur, or their pharmaceutically acceptable salts, are useful as inhibitors of the synthesis of nitric oxide. Also proposed a method of inhibiting the synthesis of nitric oxide, a method of selective inhibition of the synthesis of nitric oxide produced by inducible NO-synthase, the method of reducing nitrogen oxide and pharmaceutical composition. 5 C.p. f-crystals, 1 PL.The invention relates to the derivatives of aminotetrazole and their use in therapy, in particular to their use as inhibitors synthase nitric oxide.Since the 1980-ies it is known that the vascular relaxation induced by acetylcholine, depends on the presence of endothelium, and this activity is attributed to the labile humoral factor, named secreted by the endothelium relaxing factor (EDRF). The activity of nitric oxide (NO) as vazo the other nitrovasodilators. The recent identification of EDRF as NO coincided with the opening of the biochemical pathway by which NO is synthesized from the amino acid L-arginine by the enzyme NO synthase.NO is an endogenous stimulator of soluble guanylate cyclase and in addition to endothelium-dependent relaxation is involved in many biological activities, including cytotoxicity phagocytic cells and the communication cell - to-cell in the Central nervous system (see Moncada et al. Biochemical Pharmacology, 38, 1709-1715 (1989) and Moncada et al. Pharmacological Reviews, 43, 109-142 (1991). Currently, it is believed that excessive production of NO may affect many States, especially States, which include systemic hypotension, such as toxic shock syndrome and the treatment of certain cytokines.The synthesis of NO from L-arginine may be Engibarov analogue of L - arginine, L-N-monomethyl-arginine (L-NMMA), and it was suggested that therapeutic use of L-NMMA for the treatment of toxic shock and other types of systemic hypotension (WO 91/04024 and GB-A-2240041). Therapeutic use some other inhibitors of NO synthase, excluding L-NMMA, for the same purpose has also been proposed in WO 91/04024 and EP-A-0446699.Recently, it has become apparent that there are at m is calitanii in the endothelium and produce NO in response to receptor or physical stimulation.(ii) a constitutive, Ca++/calmodulin - dependent enzyme that is localized in the brain and produce NO in response to receptor or physical stimulation.(iii) Ca++- independent enzyme, which is induced after activation of vascular smooth muscle, macrophages, endothelial cells and other cells by endotoxin and cytokines. Once originated, this inducible NO synthase synthesizes NO in for extended periods.NO, the selected constitutive enzymes, acts as a transduction mechanism, emphasizing different physiological reactions. NO produced induced enzyme, is a cytotoxic molecule for tumor cells and invading microorganisms. It also appears that the harmful effects of excessive NO production, in particular pathological vasodilatation and tissue damage, may be largely a result of the effects of NO synthesized induced by NO synthase.There is increasing evidence that NO may be involved in the degeneration of cartilage, which takes place under certain conditions, such as arthritis, and it is well known that the synthesis of NO is enhanced when revmote is of NO from L-arginine, include autoimmune and/or inflammatory condition affecting the joints, such as arthritis, inflammatory bowel disease, cardiovascular ischemia, diabetes, hyperalgesia (allodynia), cerebral ischemia (local ischemia, thrombotic lesion and extensive ischemia, secondary stopping of the heart), and other disorders of the Central nervous system, mediated by NO, and other disorders mediated by NO.In addition, the conditions under which it is advisable to inhibit the production of NO from L - arginine include systemic hypotension associated with septic and/or toxic shock caused by a wide variety of agents; therapy with the use of cytokines, such as TNF, IL-1 and IL-2, and used as adjuvant to short term immunosuppression in transplantation.Some of the inhibitors of NO synthase proposed for therapeutic use long enough, and in particular L-NMMA, are indiscriminate in that they inhibit both constitutive and inducible NO synthase. The use of such a non-selective inhibitor of NO synthase requires great care when taking in order to avoid potentially seriously the thrombosis and tissue damage. In particular, in the case of therapeutic use of L-NMMA for the treatment of toxic shock it is recommended that continuous monitoring of blood pressure of the patient during treatment. Thus, although non-selective inhibitors of NO synthase have therapeutic utility, provided appropriate precautions, inhibitors of NO synthase, which are selective in the sense that they inhibit inducible NO synthase to a much greater extent than constitutive isoforms of NO synthase, would be even more therapeutically useful and more convenient to use.W094/12165, W094/14780, W093/13055, EP0446699A1 and U.S. patent N 5132453 disclose compounds that inhibit the synthesis of nitric oxide and preferably inhibit the induced synthase isoforms of nitric oxide. Messages, therefore, are by reference in its entirety, as described here.In a broad aspect, the present invention is directed to the inhibition or modulation of the synthesis of nitric oxide in the body of a subject in need of such inhibition or modulation, by introducing a compound that mainly inhibits or modulates the induced synthase isoforms of nitric oxide compared to constata the subject, in need of such reduction.Compounds of the present invention represented by the following chemical formula
< / BR>and their pharmaceutically acceptable salts;
where R1, R2independently selected from the group consisting of hydrogen, lower alkyl, lower alkenyl and lower quinil;
R3, R4independently selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower quinil, aryl, COR7or SO2R8where R7and R8independently selected from the group consisting of lower alkyl, lower alkenyl, lower quinil and aryl;
X is independently selected from the group consisting of lower alkyl, lower alkenyl and lower quinil, and all of them can be substituted by lower alkyl, lower alkoxygroup, hydroxy, halogen, trifluoromethyl, nitro, cyano, amino;
or X is selected from the group of the formula -(CH2)pQ(CH2)r- where p = 1-3, r=1-3, and Q is oxygen, C= 0, S(0)twhere t = 0-2, or NR12where R12is hydrogen or lower alkyl which may be substituted by lower alkyl, lower alkoxygroup, hydroxy, halogen, trifluoromethyl, nitro, cyano, amino; or
X is selected from the group of the formula -(CH2)
B-NR5R11where R5selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower quinil and aryl and R11selected from a 3-8 - membered heterocyclic radical, in which at least one member of the ring is hydrogen and in which from 1 to about 4 members are heteroatoms independently selected from oxygen, nitrogen and sulfur, and the heterocyclic radical may be substituted by hydroxyl, lower alkoxygroup, lower alkyl, halogen, nitro, carboxyla, S02R13where R13selected from lower alkyl, lower alkoxygroup, NR1R2, amino, acyloxy, trifloromethyl, phenyl and naphthyl which may be substituted with halogen, nitro, lower alkoxygroup and lower alkyl.
< / BR>2S-amino-6-[(1-iminoethyl)amino]-N-(1H-tetrazol-5-yl) hexanamide, hydrate, N,N - diisopropylethylamine (DIPEA) (5,1 g, 6.9 ml, 39,54 mmol) in 20 ml of dimethylformamide (DMF) at ambient temperature add hexaphosphate benzotriazol-1-yl-oxy-Tris(dimethylamino)phosphonium (THIEF) (6.4 g, 14,49 mmol).After stirring for 1 h the reaction mixture was concentrated under vacuum. The residue is partitioned between 60 ml of ethyl acetate (EtOAc) and 50 ml of water. The layers are separated. The organic layer is washed with 50 ml of 1 M solution of KHSO4and 2 times 50 ml of water. The product begins to precipitate, and the suspension was concentrated in vacuo, receiving 9 g of crude compound. After drying the product was then purified by boiling in methylene chloride, followed by filtration, gaining 3.7 g 1A (62,7%). Connection characterize1H YARM.1B 1A (2 g, 4.5 mmol) restore under conditions of catalytic hydrogenation using Pd mobiles when 0,352 kg/cm250% solution of EtOH/AcOH within 12 hours, getting 1,55 r (100%) 1B. Connection characterize1H YARM.1C To a stirred solution of 1B (1.55 g, 4,15 mmol) and hydrochloride of methylacetamide (0,91 g, 8,31 mmol) in 25 ml DMF added triethylamine (tea) (1.26 g, of 1.74 ml, 12,45 mmol). After stirring for 16 h at ambient temperature the reaction mixture is filtered off from triethylamine hydrochloride and the filtrate kontsentriruemoy by phase C-18 column, obtaining 0.9 g (52,3%) 1C. The product is characterized1H YARM.1 1C (0.9 g, 2,17 mmol) dissolved in 30 ml of acetic acid and add 3 ml of 4 N HCL/dioxane. The reaction mixture was stirred for 20 min at ambient temperature, then add 150 ml simple ethyl ester. After 2 h the precipitate is filtered off, washed simple with ethyl ether and dried, obtaining 0,78 g 1 (96%). Anal. Rasch. for C9H18N8O, 2HCl, 1,25 H2O: C, 30,91; H, 6,48; N, 32,04; Cl, 20,27. Found: C, 31,64; H, To 6.43; N, 32,19; Cl, 20,19. DSC so pl. 144,9oC.The compound of example 1 is also more selective than NIL. The compound of example 1 is finely crystalline product as well as all intermediate compounds. On the contrary, NIL is glass, which makes handling them.Example 2
< / BR>2S-amino-5-[[amino(nitramino)methyl]amino]-N-(1H-tetrazol-5 - yl)pentanone, hydrochloride
< / BR>2A Sample t-Boc of nitroarginine (5.0 g, 15.6 mmol) and N - methylmorpholine (1.6 g, 15.6 mmol) dissolved in a mixture of methylene chloride (CH2Cl2, 25 ml) and DMF (25 ml) cooled to -78oC. To this stirred reaction mixture in the atmosphere of nitrogen (N2) add isobutylparaben (Aldrich, 2.2 g, of 16.6 mmol). Then allow the reaction cm is t to -78oC. Sample monohydrate 5-aminotetrazole (Aldrich, of 1.62 g, 15.8 mmol) is added to the reaction mixture. The reaction mixture was allowed to warm to room temperature and stirred for 48 hours All the solvent is removed under reduced pressure and the residue distributed between ethyl acetate (EtOAc) and water. The aqueous layer was free from all water and specified in the header of the material isolated from the crude residual product (9.3 g) by chromatography.2 Specified in the title material was obtained from 2A in the manner described in Example 1.Example 3
< / BR>2S-amino-6-[(1-iminoethyl)amino] -N-(1H-imidazol-2 - yl)-hexanamide, dihydrochloride
3 Specified in the title material was obtained in the same way as 1, based on 2-aminoimidazole.Example 4
< / BR>2S-amino-6-[(1-iminoethyl)amino] -N-(1H-1,2,4-triazole-3 - yl)-hexanamide, dihydrochloride
4 is Listed in the title material was obtained in the same way as 1, based on 3-aminotriazole.Example 5
< / BR>2S-amino-6-[(1-iminoethyl)amino] -N-(5 - pyrimidinyl)hexanamide, hydrate, dihydrochloride
5 is Listed in the title material was obtained in the same way as 1, starting from 5-aminopyrimidine.Example 6
< / BR>2S-amino-6-[(1-iminoethyl)amino the way that and 1, based on 3-aminopyrazole.Example 7
< / BR>2S-amino-6-[(1-iminoethyl)amino] -N-(thiazol-2 - yl)hexanamide, dihydrochloride
7 is Listed in the title material was obtained in the same way as 1, based on 2-aminothiazole.Biological data
The activity of the above compounds as inhibitors of NO synthase define the following tests:
Citrullinemia analysis synthase nitric oxide
Synthase activity of nitric oxide measured by monitoring the conversion of L-[2,3-3H] -arginine to L-[2,3-3H]-citrulline (1,2). Inducible NOS man (hiNOS), endothelial constitutive NOS man (hecNOS) and neuronal constitutive NOS man (hncNOS), each clone from RNA extracted from human tissues. Recombinant enzymes Express in insect cells using a baculovirus vector. The active enzyme is extracted from cell extracts and partially purified by DEAE chromatography-Sepharose (2). The enzyme and inhibitors added to a volume of 50 μl in 50 mm Tris (pH 7.6) and initiate the reaction by adding 50 µl of a solution containing 50 mm Tris (pH 7,6), 2.0 mg/ml bovine serum albumin, 2.0 mm DTT, 4.0 mm CaCl2, 20 μm FAD, 100 μm tetrahydrobiopterin, 0.4 to 2.0 mm NADPH and 60 μm L-arginine, soderzhashchaya at 37oC for 15 min the reaction is stopped by adding 300 ál of cold buffer containing 10 mm EGTA, 100 mm HEPES (pH 5.5) and 1.0 mm L-citrulline. [3H]-Citrulline was separated by chromatography on a cation-exchange resin Dowex 50W X-8 and quantify the radioactivity in a liquid scintillation counter.1. Bredt, D. S. and Snyder, S. H. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 682-685.2. Misko, T. P., Moore, W. M., Kasten, T. P., Nickols, G. A., Corbett, J. A. , Tilton, R. G., McDaniel, M. L, Williamson, J. R. and Currie, M. G. (1993) Eur. J. Pharm. 233, 119-125.Compounds according to the invention are non-toxic, as evidenced by tests, for example, the compounds of example I in vivo for 0.1, 0.3, 1.0, 3.0, 10.0, and 600.0 mpk, showed the following results:
Analysis: MTOL po for example 1.5/5 0.1 mpk 5/5 0.3 mpk 5/5 1.0 mpk
Portable = 0.1 mpk Portable = 0.3 mpk Portable = 1.0 mpk
5/5 3.0 mpk 5/5 10.0 mpk 5/5 600 mpk
Portable = 3.0 mpk-Tolerance = 10.0 mpk Portable = 600 mpk
From the preceding description specialist in this field can easily set the essential characteristics of this invention and, without departing from the scope of its content and scope, can make various changes and modifications of the invention to adapt it to different needs and conditions. 1. Aminophosphonate;
Y is lower alkyl;
B - NR5R11where R5is a hydrogen atom, R11selected from 5 - to 6-membered heterocyclic radical, in which at least one ring member is a carbon and 1 to 4 member heteroatoms independently selected from nitrogen and sulfur,
or their pharmaceutically acceptable salts.2. Amino derivatives of formula (I) under item 1, where the specified connection selected from the group of 2S-amino-6-[(1-iminoethyl)amino]-N-(1H-tetrazol-5-yl)hexanamide, hydrate, dihydrochloride; 2S-amino-6-[(1-iminoethyl)amino]-N-(1H-imidazol-2-yl)hexanamide, dihydrochloride; 2S-amino-6-[(1-iminoethyl)amino]-N-(thiazol-2-yl)hexanamide, dihydrochloride.3. The method of inhibition of the synthesis of nitric oxide from the subject in need of such inhibition, by introducing the inhibitor, characterized in that as an inhibitor use a connection on p. 1 or 2 in an effective amount.4. The method of selective inhibition of the synthesis of nitric oxide produced by inducible NO-synthase, relative to the nitric oxide produced by the constitutive forms of NO synthase, the subject in need of such selective inhibition by injection of the inhibitor, characterized in that as an inhibitor opolska, in need thereof, by introducing a therapeutic ingredient, characterized in that the quality of therapeutic ingredient is used as a compound under item 1 or 2 in an effective amount.6. Pharmaceutical composition having inhibitory effect on the synthase nitric oxide in the subject in need of such inhibition, containing therapeutic ingredient together with one or more pharmaceutically acceptable carriers, characterized in that as the quality of therapeutic ingredient it contains a connection on p. 1 or 2 in an effective amount.
R-NH--Nwhere R is phenyl, unsubstituted or mono - or multiply substituted by halogen atom, lower alkyl, lower alkoxygroup, arroceros, trifluoromethyl, and unsubstituted or once substituted lower alkoxygroup benzothiazolyl, or benzoxazolyl, R1and R2means a hydrogen atom or lower alkyl, and R1and R2cannot simultaneously denote a hydrogen atom
R(I) where R1and R2the same or different and represent aliphatic group1-C3, optionally substituted by a methoxy group, cyclohexyl, or R1-R2together with the nitrogen atom to which they are attached, form a heterocyclic ring of formula II
-(II) where R8hydrogen, Allenova group, optionally interrupted by oxygen or sulfur, which may be substituted by lower alkyl or by Deputy, at two adjacent carbon atoms alkalinous group form a benzene ring or In-Allenova group with three carbon atoms,
n 0,
R3straight or branched alkyl radical containing 1-5 carbon atoms or cyclohexyl, or a group of the formula
-N(III) where R4and R4' are the same or different and represent a hydrogen atom or an alkyl group containing 1-4 carbon atoms, R5a hydrogen atom or a straight or branched aliphatic Radiatsionnaya aliphatic group with 1-5 carbon atoms, optionally substituted by actigraphy, acetoxypropionyl, alkoxygroup containing 1-3 carbon atoms, alkylthiol containing 1-3 carbon atoms, optional alkilirovanny amino group, phenyl group or cycloalkenyl ring containing 6 carbon atoms or the radicals R3and R5together with the carbon atoms and the nitrogen to which they are attached, form a heterocyclic ring of formula IV
(IV) in which R6has the specified values, R9and R10the same or different, are hydrogen atom or alkyl group with 1-4 carbon atoms, D Allenova group with 2-5 carbon atoms or the radicals R3and R5together with the carbon atoms and the nitrogen to which they are attached, form a heterocyclic ring of the formula V
(V) where R6has the specified values, R11a hydrogen atom, an alkyl group with 1-2 carbon atoms,Allenova group with 2 carbon atoms, or R5and R6together with the nitrogen atom to which they are attached, form a heterocyclic ring of the formula VI
-Nthen, at least one of R4, R4', R5or R6different from hydrogen
FIELD: medicine, oncology.
SUBSTANCE: the present innovation deals with treating patients with uterine cervix cancer with relapses in parametral fiber and in case of no possibility for radical operative interference and effect of previous radiation therapy. During the 1st d of therapy one should intravenously inject 30 mg platidiam incubated for 1 h at 37 C with 150 ml autoblood, during the next 3 d comes external irradiation per 2.6 G-r. During the 5th d of therapy one should introduce the following composition into presacral space: 60 ml 0.5%-novocaine solution, 1 ml hydrocortisone suspension, 2 ml 50%-analgin solution, 1 ml 0.01%-vitamin B12 solution, 1.6 g gentamycine, 800 mg cyclophosphan, 10 mg metothrexate. These curative impacts should be repeated at mentioned sequence four times. The method enables to decrease radiation loading and toxic manifestations of anti-tumor therapy at achieving increased percent of tumor regression.
EFFECT: higher efficiency of therapy.
1 ex
FIELD: medicine, cardiology.
SUBSTANCE: the suggested method should be performed at the background of medicinal therapy with preparations out of statins group, tevetene, polyoxidonium and conducting seances of plasmapheresis by removing 800 ml plasma twice weekly with N 5 due to additional intramuscular injection of immunophan 0.005%-1.0 with N 10 and fluimucyl 300 mg intravenously daily with N 5-10, total course of therapy lasts for 2 mo. The method provides modulation of leukocytic functional activity, moreover, due to altered cytokine profile and, thus, through disintegration of protein-lipid complexes participating in the development of atherosclerotic platelets.
EFFECT: higher efficiency of therapy.
3 ex


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Paws-Galore Pet Services
Kemsley, Kent
Kemsley, Kent
We offer a comprehensive service to cater for all your pets needs. In a free initial consultation, we will discuss with you the type of service that would be best suited to your pet.
Bill Pennell
Brilliant service from Lois. Reliable, helpful & flexible especially considering she takes care of my two lively & excitable boys. Her doggy day care service allows me to work in London safe in the knowledge the boys are being well looked after and for piece of mind afterwards she drops me a note to say everything ok. Would recommend highly. More...
Fantastic. Saved my life. Would highly recommend.
What do you love most about your job?
Getting the chance to spend time with each dog or cat and forming a lasting friendship with them.
What inspired you to start your own business?
Having worked with animals for many years, it seemed a natural progression to start my own pet care business.
Why should our clients choose you?
I offer a unique personalised service which means each pet is given 100% attention and care.


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The Chairman
- Joined
- Apr 17, 2009
- Messages
- 43,133
- Likes
- 23,720
Again, you are jumping the gun without adequate knowledge of the world's colonial history.The west must be evil in nature. That is the only conclusion you can draw from here.
Indeed the imperialists and colonialists were brutal, cruel and heartless. You have any doubt? That photograph above your said post should give you an idea. Show me one British chap in Briton or British India of the time as impoverished and starving as those Indians in the picture.
Reproduced below to charge your brain cells for recollection
Just think how the British Empire, where it was said that the Sun never Sets in the British Empire, crumbled after that they called Jewel of the Empire, yes, India got Independence?
The Golden Goose was no longer to feed them and their extravaganza, at the cost of the Golden Goose.
And it is NOT the WEST THAT IS EVIL. Just the imperialists and colonialists.
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"I am sure that the One who began a good work in you will carry it on until it is completed. That will be on the day Christ Jesus returns."
Philippians 1:6
Reflect on various ways people seek peace for themselves.
ASP's 2020 Theme — Complete, but not Finished — encourages us that we are each a work in progress. God isn't finished with us yet, but God's work will not be denied.
As you prepare to serve with ASP in 2020, we hope you will use the following pre-trip sessions to get to know ASP, to get to know your group, and to get familiar with this year's theme.
Session One
An introduction into Central Appalachia, ASP, and the 2020 Theme.Get the Files for MacGet the Files for Windows PC
Tool Training Exercises
Give your volunteers a chance to use tools hands on before their trip by completing the projects belowPicnic Table: Detailed Instructions HereStep Stool: Detailed Instructions Here
For more information about logistics, recruitment, and preparation, visit our Group Leader Resources pageAccess Resources
Have questions or feedback about the pre-trip sessions? Contact ASP's Director of Spiritual Programs, Neal Bowes
Did you know that ASP launched a Scholarship program? If you have group members that cannot attend ASP due to financial reasons, click the button below and apply on their behalf so they can serve with you on your next trip!


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The Kano State Government said on Thursday that it had trained 750 women on bakery, weaving and embroidery.
Governor Rabiu Kwankwaso, who announced this in Kano at the graduation of the trainees, said that the training was organized to empower women in the state.
He said that the youths, selected from all the local government areas of the state, were trained to eradicate poverty among women.
Kwankwaso also said that the training was organized to make the beneficiaries self reliant and contribute their quota to the development of the state.
He said that the government spent over N20 million in the training and empowerment of 750 women.
The governor also presented an empowerment package of N20, 000 each to all the beneficiaries.
One of the beneficiaries, Amina Sabo commended the state governor for empowering women in the state.
Dr. Binta Tijani, the state commissioner for women affairs commended the governor for supporting women in the state.
The commissioner also urged the beneficiaries to make the best use of the knowledge acquired during the training to become self-reliant.


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Music at Bromsgrove
Curricular and Co-curricular music together form the basis of an integrated, practical and engaging approach to musical learning at Bromsgrove. Our students develop their skills, knowledge and understanding of music through a combination of performing, creating, listening and appraising. All students from Reception through to Year 9 receive specialist music lessons as part of their timetabled learning, with a number of students going on to study Music and Music Technology at GCSE and A Level. Our co-curricular opportunities include individual music lessons, orchestras, choirs and a rock school, as well as participation in FOBISIA and TISAC events.
At Bromsgrove we ASPIRE to make music learning…
- Ambitious – all learners are encouraged and challenged to achieve their potential.
- Sociable – learning is collaborative and with friends.
- Progressive – music learning experiences are varied and high quality, with clear progression routes.
- Inclusive – everyone is a musician and can learn and develop at their own level and in their own way.
- Relevant – learners discover music that they engage and identify with, across a range of genres and styles.
- Engaging – learning is practical, hands-on and fun!
Bromsgrove Music Academy
Bromsgrove Music Academy offers high-quality music tuition to all students in Years 2 to 13. Lessons are delivered by full time Bromsgrove staff and visiting teachers from 2 Learn Music, in association with the UK's Associated Board of the Royal Schools of Music (ABRSM).
Tuition is available in voice, piano, ukulele, classical guitar, acoustic guitar, electric guitar, bass guitar, drum kit, violin, cello, flute, clarinet and saxophone. Lessons during the school day has the full support of class and subject teachers. The 30-minute lessons are scheduled on rotation to ensure minimal disruption to academic lessons. Priority for after school lessons will be given to Secondary students and students at Grade 4 level and above.
Tuition Fees
- New Starter / Grade 1-3 (Beginner) – 30 minutes: THB 600
- New Starter / Grade 1-3 (Beginner) – 60 minutes (after school only): THB 1200
- Grade 4-5 (Intermediate) – 30 minutes: THB 700
- Grade 4-5 (Intermediate) – 60 minutes (after school only): THB 1400
- Grade 6-8 (Advanced) – 60 minutes (after school only): THB 1600
- ARSM or DipABRSM (Grade 8+) – 60 minutes (after school only): THB 2500


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Squishy! Black Clover (Anime) ➜ Forum ➜ ReviewsMugyutto! Black Clover / むぎゅっと!ブラッククローバー
- TypeWeb
- Episodes8 (~)
- Release Date01. Jul 2019
- Main genresComedy
- Country of OriginJapan
- Adapted FromManga
- Target GroupMale
Anime Reviews
This topic contains short as well as longer reviews on the anime "Squishy! Black Clover" and is by no means the right place for general discussions! Each post must be a stand-alone review that you wrote yourself. Each review should cover certain core aspects: plot, characters and a have a personal conclusion. Feel free to comment on existing reviews using the comment function.


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Follow INSIDER on Facebook.
- By early Tuesday morning, the massive fire that ravaged the Notre-Dame Cathedral in Paris was contained, hours after the flames first erupted on Monday evening.
- On Monday, images from the outside of the more than 800-year-old cathedral revealed a roof aflame. Shocking videos captured its iconic spire collapsing.
- Photos taken Tuesday offer a glimpse the inside of the cathedral.
- The architectural, historical, and artistic wonder, has become a symbol not only for Catholics but also for Parisians as a whole.
- Visit INSIDER.com for more stories.
The massive fire that broke out and burned well into the night at the Notre-Dame Cathedral in Paris on Monday evening was "completely under control," as of early Tuesday morning, according to authorities. It is now fully extinguished.
Images from the outside of the more than 800-year-old cathedral revealed a roof aflame, and shocking videos captured its iconic spire collapsing. Now, several photos offer a glimpse of the inside of the cathedral.
Construction of the Notre-Dame Cathedral began in 1163; it took more than a century to build and was finished in the 13th century. The cathedral, an architectural, historical, engineering, and artistic wonder, has become a symbol not only for those practicing Catholicism but also to Parisians and visitors from around the world.
The fire, which is believed to have started in the attic of the cathedral, broke out at around 6:30 p.m. local time Monday. Around 400 firefighters worked to contain the flames; officials said one was seriously injured.
There is still much that is unknown about the fire, including what started it, and the extent of the damage inside of the cathedral (paintings, sculptures, the organs, and more).
Here's what photos from the inside of the cathedral show thus far.
Firefighters doused flames from the burning Notre-Dame Cathedral as people looked on in Paris on Monday evening.
The fire consumed part of the roof, and the iconic spire collapsed due to the fire.
The flames engulfed the roof.
The fire completely demolished the wooden frame of the building within the stone exterior.
A closer look shows the altar surrounded by smoke.
The cross and altar, along with the sculpture of Pieta by Nicolas Coustou, are more visible along with smoke in this photo from the Associated Press.
A view of the entrance to the cathedral shows it largely intact.
Jordan Fischer, a digital investigative reporter at WUSA, gave a closer look at what can be seen inside the cathedral:
—Jordan Fischer (@JordanOnRecord) April 15, 2019
The glow of flames could still be seen inside of the cathedral early on Tuesday.
The flames were finally extinguished after the fire burned for 9 hours.
Large chunks of the cathedral's glorious vaulted ceilings had burned through.
The hulking framework of wooden beams that supports Notre-Dame is composed of huge pieces of timber, which is ripe for catching light, Business Insider's Hilary Brueck explained.
The supports are even called a "forêt" (or forest) because they're enormous pieces of oak. This "charpente" (or frame) was built from 1,300 oak trees, enough wood to fill more than 21 hectares of land, La Tribune reported.
The fire burned holes through the vaulted ceiling. From inside the cathedral on Tuesday, you could see the sky.
The New York Times reported that the wooden roof structure was not equipped with sprinklers.
Source: The New York Times
Officials are just beginning their investigation into what caused the fire.
"Nothing at this stage suggests a voluntary act," Rémy Heitz, a prosecutor in Paris, said, according to The New York Times.
It is believed that the fire began in the attic; an alarm sounded at 6:20 p.m. local time, but even after an initial check, the fire wasn't found until a second alarm went off 23 minutes later, The Times reported.
Source: The New York Times
Many of the famed glass windows appeared to be safe.
"It seems they have not been destroyed for now, although we'll have to see what real state they're in, and whether they can be restored properly," Maxime Cumunel, secretary general of France's Observatory for Religious Heritage, told Reuters, of the stained glass windows, including the famed rose windows.
Source: Reuters
Notre-Dame's iconic spire toppled during the blaze.
Videos captured the fateful moment:
—Wladimir Garcin-Berson (@vladogb) April 15, 2019
Rescuers reportedly formed human chains to pull as many priceless relics out of the church as possible before they were destroyed.
According to the mayor of Paris Anne Hidalgo, firefighters managed to rescue some relics from the cathedral, including "linen fabric associated with Saint Louis, the Holy Crown of thorns and the cathedral's treasury," The New York Times reported.
Sixteen bronze statues had been removed last week as part of the ongoing renovation work.
The cathedral's two towers seemed to have survived the blaze.
The fire chief Jean-Claude Gallet said he believed "that the two towers of Notre-Dame have been saved," referring to the two iconic towers at the front of the cathedral.
"We now consider that the main structure of Notre-Dame has been saved and preserved," he continued.
The towers looked sturdy from the outside on Tuesday. But the wooden frame of the cathedral is "still precarious."
The weight of the waterlogged wooden structures still poses a serious threat to the building's integrity, expert Philippe Charlier told Business Insider France.
"The wood has been drying out over roughly 800 years and, as a result, it was relatively 'light,'" Charlier said. "It's now completely saturated with water."
"The cathedral appeared to be structurally sound, officials said, after an inspection," The Times reported on Tuesday.
Sources: Business Insider France, The New York Times
French President Emmanuel Macron has promised the cathedral will be rebuilt.
"We will rebuild it," he said in a Tweet on Monday night. "All together."
It will likely take years to rebuild.
Luckily, some of France's richest residents and biggest companies have pledged over $675 million to rebuild the cathedral.
By Tuesday afternoon, Bernard Arnault, François-Henri Pinault, the Bettencourt family, French oil giant Total, Crédit Agricole bank, and L'Oreal had all joined the cause.


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Haemorrhoids rushed the restitution process by ANRP
Illnesses such as paranoia or haemorrhoids were among the reasons given in support of the exceptional cases which were solved with priority by the National Authority for Property Restitution (ANRP), according to a report released by the Prime Minister's Control Body.
Data provided by ANPR during the control show that during 2008-2011 some 1,407 files were solved by the numerical order of registration and 2,269 were solved with priority as exceptional cases, of which 131 were solved in favour of rights assignees, hotnews.ro reports.
"In fact, the members of the Central Commission for Establishing Compensation have turned exception into rule," the report reads.
Among the grounds claimed to support the exceptional cases there were illnesses such as paranoia, sciatica, osteoporosis, recurrent depressive disorder, panic attacks, irritable bowel syndrome, haemorrhoids or psoriasis.
An applicant has not submitted any documentary evidence, but claimed he was 82 and needs three costly surgeries, and another one said he is 93 years old and lives in the United States on welfare. The Prime Minister's Control Body has identified a person who claimed to be an exceptional case because it is persecuted on ethnic grounds.
The ANPR information provided to the PM's Control Body reveal that in the rankings of priority compensations for exceptional cases there is a person who received more than RON 108 million (approx. EUR 24 million).


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Orange, France's largest telco operator, may come to Nigeria in months
Orange would also be looking at bolstering partnerships with health companies or institutions.
France's largest telecom operator, Orange, is set to extend its tentacles to Nigeria and South Africa.
Chief Executive Officer, Orange, Stephane Richard, who disclosed the news, said that the firm would make the move in a few months.
He said, "It could make sense to be in economies such as Nigeria and South Africa. If one considers there are things to do, the time frame I am considering is rather a few months than a few years."
READ ALSO: French telco inks investment partnership with MainOne
The Middle East and Africa, where Orange has a presence in 18 countries, is the company's fastest-growing market.
What you need to know: There are chances that the company may eye payment transfers (mobile) in Nigeria.
That is because it makes the largest chunk of its revenue from payment transfers (Middle East), a key part of the group's diversification into financial services, and Nigeria, which is the most populous black nation, is always an attraction.
READ MORE: Multichoice to integrate Netflix, Amazon contents into decoder
Meanwhile, earlier in 2020, Orange had stated that it was bringing its operations in the Middle East and Africa into a single entity, paving the way for a potential listing of the operations that could raise cash to invest in overseas expansion.
"Orange would also be looking at bolstering partnerships with health companies or institutions," he added.
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Good day Mr. Abiola. Thanks for the article. Please I would like to get in touch with you. Kindly reply me by my email. Many thanks
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China more willing to restructure Africa's debt than private creditors
Agreements have been easier to reach with Chinese lenders than with private creditors.
A recent study by John Hopkins University reveals it may be easier for African Nations to raise debt and also get debt relief from China than private creditors.
The report of the study comes a day after China promised to cancel interests from loans to African nations and restructure debt to Africa. The study also revealed that China has restructured $15 billion of African debt and written off $3.4 billion in the past ten years.
After 1,000 Chinese loans, including restructured Mozambican and Republic of Congo debt, were analysed, the researchers concluded that "the agreements have been easier to reach with Chinese lenders than with private creditors".
The Paris Club recently agreed to pause debt payment valued at $11 billion for the poorest 73 nations freeing up capital to tackle the coronavirus pandemic. However, not all eligible nations signed up citing fears of default ratings if debt obligations are not met.
The study discovers difficulties in renegotiating terms on International Bonds for African countries due to the disparate ownership structure making private creditors unwilling to grant complete debt relief, citing warnings on rating downgrades.
China accounts for about 20% of Africa's external debt and lent over $150 billion to the continent between 2000-2018 the study reveals. Chinese President, Xi Jinping has urged global leaders to be more pragmatic with debt suspension for Africa.
The study says much of the terms of Chinese debt to Africa has not been transparent and the relief negotiations may follow the same path.
LIRS further extends deadline for filing annual tax returns by one month
"We constantly debated what other measures could be taken as an organization to support individuals and businesses at this time, hence, the additional one-month extension from June 1, to June 30, 2020." – Ayodele Subair
The Lagos State Internal Revenue Service (LIRS) has again extended the deadline for filing of Annual Tax Returns from May 31 2020 to June 30, 2020.
This is part of the state government's effort to provide relief to taxpayers in light of the economic impact of the Covid-19 pandemic. With this development, annual returns for individuals, both employees and self-employed persons, can be filed anytime before June 30, 2020.
In a press release signed by Monsurat Amasa, the head of LIRS' Corporate Communications Department, the agency urged taxpayers to take advantage of the magnanimity of the government and file their returns. The LIRS' Executive Chairman, Mr. Ayodele Subair, explained the extension thus:
"As the Lagos State Government keeps abreast of global best practices in containing the Covid-19 pandemic and eases the effects of an economic downturn on taxpayers and residents of the State, LIRS had initially extended the deadline for filing annual tax returns for two months, from the statutory March 31st of every fiscal year to May 31, 2020.
"We constantly debated what other measures could be taken as an organization to support individuals and businesses at this time, hence, the additional one-month extension from June 1, to June 30, 2020."
(READ MORE: COVID-19: Lagos issues new guidelines, considers full reopening of economy)
He further explained that taxpayers can file the annual returns from the comfort of their homes and offices using the LIRS eTax platforms. They can also generate assessment and payment schedule, and other tax administration matters on the same platform. Updates on business operations and alternative payment platforms are to be found on the verified handles, and the LIRS website.
Where to invest in May
Post-COVID-19 lockdown, Nigerians need to send their money on the right errands in May 2019, if they will not be caught napping the expected recession.
This May, post-COVID-19 lockdown, Nigerians need to send their money on the right errands, if they don't want to be caught napping during the anticipated recession.
When listing out assets that should make up the ideal portfolio in May 2020, founder of Nairametrics, Ugochukwu "Ugodre" Obi-Chukwu, explained that investors should consider choice stocks in the Nigerian and foreign stock exchanges, as well as investments in money market instruments where some decent profits can be made.
Ugodre said this during the maiden edition of the Nairametrics Monthly Investment Guide Webinar.
According to him, this will also be the time to look into Agri-Tech investments, using crowdsourcing platforms, after which you can sit back and watch your funds grow over a time span of 5 months to a year.
According to him, it is also important to invest in foreign currencies and crypto-currencies to balance one's portfolios.
He noted that foreign direct investments have reduced over the last couple of years due to reduced trust in Nigeria's economic policies, and the desire of foreign investors to cash out their funds with ease. This also explains why portfolio investments grew by 38% in 2019.
He said, "Foreign investors love portfolio investments because when they put their money in, they can easily take it out as well."
(READ MORE: CrowdFunding: Who is qualified according to new SEC Guidelines)
Finding the right stocks
On the stock market, he noted that quite some stocks improved in the month of April and could improve in the coming months. He listed 20 suggested shares, including six stocks which he described as COVID-19 proof.
Dangote Sugar Refinery, May & Baker Nigeria Plc, GSK, Neimeth International Pharm, Nestle Nigeria, and Cadbury Nigeria Plc are fast-moving consumer goods companies that are expected to be resistant to pressure from the pandemic.
He advised investors to track stocks that are liquid, have good financials and good corporate governance, in order to limit risks borne by investors. Valuation of the shares, he said, could be done by comparing stock value and earnings per share.
Working around cryptocurrency volatility
While making a presentation on "Why Bitcoin should be in your portfolio," Yele Badamosi, CEO of Bundle stated that foremost cryptocurrency, Bitcoin, had maintained a steady appreciation over the last decade giving investors high yields.
Although the market is highly speculative and unregulated, its high returns and high risk indicate that investors with high-risk appetites could find the market more attractive.
To avoid being on the wrong side, he advised users to consider time-based rebalancing, or tolerance rebalancing to reduce risks and rebalance one's portfolio.
(READ MORE: AfCFTA delay: A bane to Africa's $3.4 trillion economic bloc)
"There are reputable people in the space, but it is important to do your research, start small, and buy regularly. Be wary of get-rich-schemes and unrealistic guaranteed returns," he advised.
With applications like Bundle Africa on Google Play Store, buying cryptocurrencies is as easy as selecting the buy button and having it saved in your bundle wallet.
What to expect in Q2 2020
According to Wale, an economist, who also spoke at the webinar, the demand for crude oil will remain low as several countries and businesses are still in lockdown, even though OPEC has cut down production.
Interest rates may remain low, though, despite this, Nigerian business entrepreneurs cannot expect single-digit interest rates.
"Foreign reserve and government reserves will remain under pressure in the coming months. The World Bank says that this is the worst year so far, going back to the great depression and this is what I think as well. This is probably going to be the worst economic crisis we have seen," Wale said.
He added that with the exception of industries in the Healthcare sector, telco companies, digital technology companies, and food producers, other sectors could very well expect a big hit.


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2019 Dodge Challenger SXT Plus Demon Price – This 2019 Dodge Challenger will be the muscles-vehicle that could do all of it. Through the access-degree product having its 305-hp V6 together with accessible all-tire push, in order to significantly hairy chested V8 versions varying up to this revved-up SRT Hellcat as well as SRT Demon, this specific 5-traveler 2-front door combines traditional muscles vehicle hints and even performance with the contemporary modern technology you could potentially would like.
It's inside provides cozy chairs, great-technology characteristics for example Apple CarPlay plus Google android Car, as well as a amazingly peaceful plus processed drive. Them possibly delivers 5-celebrity collision-examination scores from your Office regarding Travelling. Nonetheless otherwise you believe this unique vehicle is way too useful, produce zero blunder: There is not any Ford Mustang or perhaps Chevrolet Camaro that could go with your Hellcat's 707 hp, a lot less a pull-competition-completely ready Demon's 840 horses. This is certainly when severe when muscles becomes.
2019 Dodge Challenger Redesign
Exterior Design
The actual 2019 Dodge Challenger traditional very long-hood/quick-outdoor patio dimensions and even broad posture protest performance in just about every product, along with their own flared fenders along with other information, a Hellcat Widebody plus SRT Demon scream the item in full. Particulars similar to bonnet scoops, badging not to mention non-obligatory lines toss in any old style really feel.
2019 Dodge Challenger Release Date
It simply appears great, effectively combating the need being excessively outdated-created and stays modern in addition to contemporary having a incredible charm as well as the strong swagger of your MMA winner. And when which will swagger is not ample you can even secure several of the dazzling colours with all the enjoyable titles because of in the day time, for example IndiGO Azure not to mention Plum Insane.
Interior Design
You may never ever realize that the particular Challenger appeared to be able to shenanigans looking at the nice and cozy internal. This touch-screen within the centre is definitely an outdated good friend, improved this season using Uconnect 8.4, that can bring Apple CarPlay and even Google android Car.
2019 Dodge Challenger Interior Design
There exists a old style think that nevertheless appears contemporary, and that we much like the huge driver information centre involving the primary gauges. Undoubtedly, your heavy back pillars try taking some becoming accustomed to, nevertheless sightless-area caution as well as a back-up digital camera make your Challenger simple to push. The back seating can certainly fit 3 throughout, uncommon with this class, as well as the trunk area is in fact massive, even if having a great liftover.
2019 Dodge Challenger Engine
This 3.5-liter V6 around SXT plus GT versions delivers it has the 305 hp either to the back as well as all rims using an 8-velocity auto transmission. The actual 5.7-liter V8 within the R/T in addition to T/A variations helps make 375 hp having a 6-velocity handbook transmission or simply 372 with all the 8-velocity auto. All the R/T Scat Load, 392 Hemi Scat Load Shaker, T/A 392 in addition to SRT 392 reveal the identical 485-hp 6.5-liter V8.
Any SRT Hellcat provides any 6.2-liter revved-up V8 by using 707 hp, which will help it become this master of your mountain whether it just weren't to the 840-hp about competition fuel) SRT Demon. Virtually all V8-run challengers other than the actual Demon could be requested having a 6-velocity handbook transmission, however the 8-velocity auto is not going to shortchange performance. Naturally, nothing of those autos will be energy-economic system kings, while the V6 versions are usually not poor.
2019 Dodge Challenger Price And Release Date
The particular Automobile Advised Retail store Value with a basic product Dodge Challenger SXT commences located at concerning the $28,100 symbol, like the $1,095 spot fee, plenty of vehicle for the investment.
Add more in relation to $6,000 to the all-tire push and better products measure of the actual GT. That properly outfitted R/T with all the 5.7-liter V8 commences in regarding $34,500, even though the R/T Scat Load and its particular 6.4-liter V8 commences for related to $40,000. A SRT 392 is extremely properly outfitted, justifying it is $50,500 value label.


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Alaskan Spruce is a brilliant aroma replicating the scent from a freshly cut spruce tree. It's got a vibrant citrus note that is enchanting and quite pleasing. A true Christmas tree fragrance. We have tried and tested many similar pine tree, fir, and balsam oils and this one, Alaskan Spruce is perfection {hand poured in a reusable modern frosted jar with shiny silver lid and handstamped silver charm which reads STRENGTH}
Each candle from our VIBES Collection includes a lovely silver hand stamped charm with our key logo and a word similar to the candle purchased. You can decide to keep it around the candle, or slip onto a necklace, bracelet, keychain, purse or top off a gift!
candle details:
- hand-poured in small batches
- all-natural non-toxic, clean burning 100% USA-grown soy wax infused with premium beeswax
- phlalate free fragrance oils & essential oils
- 100% dye free - vegetable wax coated cotton braided wick
- 9 ounce, 65+ hour burn-time
- reusable vintage style jar
- hand stamped silver disc charm ~ stamped with a key and the words GET TOASTY.
- 18 years candle-making experience, lovingly hand-poured in our studio in the mountains of NJ
To get the most out of your candle, make sure you let the first burn give a memory to the candle, by letting it burn to the edge, and trim wick before each use thereafter. Please be sure to read care instructions included with your candle. Thank you for viewing!
House 33 Candle Co. purveyors of soy-beeswax & essential oil organics,
organic soy beeswax candle Alaskan Spruce | Vibes Collection - Strength
Unused, new candles may be returned in same packaging within 14 days of shipment. Used or burned candles will not be refunded. Please contact us at email@example.com for a return authorization code.
This candle is hand poured + cured and ready to ship! It will ship out within 24 hours after your payment is made or if paying with check then when it clears. We ship USPS priority insured. ONE FLAT RATE for your whole order, so stock up! and FREE shipping with product ordered over $50.00! Within less than a week you will be enjoying your organically crafted candle!


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Apart from adding the much needed pungent zing to your dishes, ginger is also replete with multiple medicinal properties and benefits. It has a surprising amount of health benefits, from glowing skin to fighting off colds. To fully enjoy the medicinal benefits of ginger, it is recommended to use it in the form of 'Ginger water'.
Here are some top benefits of Ginger water and it can be easily made at home!
Aids in Weight Loss
Accompanied with healthy eating habits and regular exercise, ginger water can also give a boost to your weight-loss plans.
Ginger water may help decrease some types of pain. In a study that involved 60 adults with migraine pain, researchers found using ginger as an add-on therapy was better than taking painkillers alone.
People have long used ginger as a herbal treatment for nausea. In a 2015 review, researchers looked at nine studies in which people used ginger for postoperative nausea, chemotherapy side effects, viral nausea, and morning sickness. The studies, although not always clinically watertight, all indicated that ginger provided a reduction in nausea and vomiting.
Checks Cholesterol
Many a studies and research have proven that ginger could lower-down 'bad' cholesterol levels, and therefore, helps keep your heart health intact.
Keeps you hydrated
A lot of people miss out on the daily recommended amount of water intake, which leads to dehydration, that could be very problematic and dangerous for your health. An additional source of water, as in, ginger water could help supplement your fluid intake, and therefore keep you hydrated.
Anti-Inflammatory effect
Although a natural bodily process, inflammation (in excess) may end-up harming your body. It has become a common problem these days among a lot of people. Thankfully, ginger is known to have anti-inflammatory effects and therefore helps prevent inflammation.
Incredible & Proven Health Benefits Of Ginger
Ginger water is made from four ingredients, water, lemon, raw honey, and ginger. It's that simple.
- 2-inch piece of ginger
- 3 cups filtered warm water
- 1 lemon
- 1 tsp of organic raw honey
Grate 1.5 teaspoons of fresh ginger
Boil 4 cups of water
Add the ginger to the water
Remove the water from the stove
Allow the ginger to steep for about 5 to 10 minutes
Strain the liquid to remove ginger pieces and add honey
Allow the water to cool enough to drink or place in the refrigerator and drink cold.
Ginger has a strong taste. For some people, adding a flavoring, such as honey or lemon, may improve the taste.
Also Read: Effective & Healthy Home Made Tonics To Strengthen Your Immune System
People who drink ginger water in excess may experience mild side effects, including:
- Gas
- Abdominal pain
- Diarrhea
- Heartburn
Do not forget to share your experience in the comments section! We Would love to hear your beautiful thoughts!
For the latest health tips and recipes, like us on Facebook or follow us on Twitter and YouTube
Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information.


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|Related Quests:
Known Drops:
To find this mob in-game, use BACKSPACE to open the World Search window, then enter Kal'Turstan in the Search field and click "Search". Remember, the field is case-sensitive and must be entered exactly as shown.
A Word About Common Drops: Every mob in the game has a chance to drop Health Potions, Mana Potions, Ammunition, Runes and Festival Items, as well as a few rarer items such as Amulet of Light. For this reason, we discourage listing them in the Known Drops section. See Common Drop Table for more information. Exception: All mobs always drop the same Production Rune and we will list it. Also see Dust Devil Canyon (Zone Loot Table) for more information about common drops in this zone.
Monster Compendium Card
+5 Defense
Need a picture for this card. Please upload one to File:Card - Kal'Turstan.jpg
Location: Dust Devil Canyon
|Stationed in front of the queen's chamber as patiently as Kal'Turssi, it neutralizes any threats that may put the queen's life in danger.
This monster has a Monster Compendium card, Card - Kal'Turstan, that can be earned by killing it and looting the corpse. You can right-click the card to copy it into your Monster Compendium.
Adding this card to your Monster Compendium will grant a permanent stat boost of +5 Defense so long as this card is in your Monster Compendium.
Spawns in front of the Queen's Chamber every two hours along with Kal'Turssi.


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It wasn't totally innovative, but it was really well executed. Awesome game.
It wasn't totally innovative, but it was really well executed. Awesome game.
It's a really cool game, but there's one thing that almost kills the fun (for me). It might sound like a small thing, but because there's no constant sound when you "use" the chainsaw, just when you "begin", it takes away a big something off the game.
There's a bug.
I dont know if it has been said, but there's a major glitch:
If you set up a versus game with 2 players (2 "humans", not AI), after you've played a match, the settings are still the same (2 humans, map and characters), but if you then press play again, it starts a match with one player and one AI enemy.
Overall, sweet game, though.
Ah, I think I can see why that would happen. That's what I get for rushing things in at the last minute, heh. Thanks for pointing that out.
Pretty good.
It sure is a great game, but there are some parts that are simply annoying and the flash-8-filters in the menu don't make it look good at all. To prevent the game from running slow and lagging, you might probably convert the backgrounds to .jpg or gif.
Overall a it's a great game but sadly with some annoying parts too.
Best conversion yet!
Yay, it's on NG finally!
That's a really fancy conversion; I sill love it.
Correct me if I'm wrong, but is this just a simple copy of eyezmaze's grow RPG?
Hmmm, nice game, bad backgrounds.
I overall liked the game alot, but the intro seemed to be not that good and also the sound and the backgrounds could be more detailed. The music was great, though.
But there's a nasty bug: If you jump on the ceiling at the very beginning of the 2nd level, you suddenly get to the 3rd stage.
Very cool game
That's a really cool game you made there, very original.
The graphics in the intro weren't as good as in the game, but that doesn't matter.
There's still a big fat bug: when you press the Q at the top right corner during the 1st level, you suddenly skips the 1st level and goes to the next level.
Cool one!
but there's a bug in the instructions:
it says there "move with W and A" but you move with A and D...
Yeah yeah yeah yeah yeah yeah yeah...
Stupid shit typo. It's fixed now. As are all the other bugs people have been finding. THE FIRE ARROWS AREN'T SUPPOSED TO BE UNLIMITED. That was a glitch that I have now stomped to death.
hey man!
that's a really cool FUN game... not the best... but for "the little fun"...
its cool!
I like salt.
30, Male
Jimminy Cricket Funky School
Joined on 3/12/04


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Great article here about the benefits of an In-Law-Unit and the growing demand for In-Law-Units from around the country. Click here for a link to the article.
Start your project with New Avenue today!
Get Started
Get Started
Still have questions? We are available to discuss your goals & ideas. There's no fee or commitment.
Set up a call time
Set up a call time


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Multiple Teams · DCHS Girls Soccer Player Callout Meeting 11/30
Player Call Out Meeting today at DCHS from 4-5pm in Room 237 by the East Gym. 8th graders welcomed.
Player Call Out Meeting today at DCHS from 4-5pm in Room 237 by the East Gym. 8th graders welcomed.
It's time to honor our 2018 Girls Soccer Team with our annual Season Awards Banquet. Date: 10/25/18 Time: 6:30 pm Location: DCHS Cafeteria This occasion is business casual/semi-formal.
We will be having a Mandatory Parent Meeting, Wednesday 8/8 at 6:30 pm in the Hospitality Room through Door 16 by the main gym. Itinerary: Season schedule, Player requirements/protocols, Parent/player expectations, Homecoming Parade, etc Questions, please contact Coach Keith at firstname.lastname@example.com.
Bus leaves DCHS Door 16 @ 9:15am and will return around 4:00pm. This tryout is to test your communication skills, leaderships skills, mental toughness, how you work within a team, and how you can bounce back from challenging situations. If you have questions or concerns contact Coach Keith at 317-489-1219 or email@example.com.


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Metropolitan drug dealer was selling amphetamine by mail
May 26, 2019 | News | No Comments|
"The citizen of Ukraine has established the delivery of amphetamine from Kiev to Odessa with the use of services of postal operator. In the future retail sales of the drug were due to be implemented within the Odessa region", – said the press service of the Ministry.
The man the package was 110 gr of amphetamine. In addition, in the vehicle and the place of residence of the detained during the searches discovered ecstasy tablets, amphetamines, marijuana, means for filling and using drugs, Bank cards and mobile phones. Seized from a drug dealer substance previously estimated in 50 thousand hryvnias.
The man declared on suspicion of committing a crime under part 2 St. 307 criminal code of Ukraine.


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If you need to have a dumpster rental in El Cajon, CA, call 888-371-6897 and your life will be made easier right away. Don't stress out trying to manage things that we can do for you. Rent a dumpster for a great price and eliminate all that extra trash!
Why rent a dumpster? It gives you a spot to put all that garbage and all you need to do is contact the company when you're done and they transport it away. Renting a temporary dumpster is ideal for larger household waste removal projects. There is no need to pile it all in your car. We have small rentals starting at low prices!
Dumpster Rental Made Easy For You and Your Family
Dumpster Deliveries is the best organization for you to rent a dumpster from in El Cajon, CA.
- Numerous dumpster rental options
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When you use Dumpster Deliveries, you are only able to gain. There is not a junk removal job out there that we don't have the resources to manage. All costs are included so you don't need to worry about paying for the dumpster rental and then discovering hidden pickup charges. Also, our customer service is excellent, so you'll never be on your own or forgotten when you go through Dumpster Deliveries.
Safe and Efficient Trash Removal
There are many advantages to renting a dumpster in California including:
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If you or your close friends have to haul your own junk, you could be making some big mistakes. For example you're taking a chance when you eliminate your own waste. Second, it takes a great deal of your time to get rid of your waste. You could be working and earning money (or sleeping) instead of removing trash. Lastly, you may be violating city codes when you eliminate your waste. Any time you hire specialists to manage your garbage removal, all those problems disappear.
Get All the Professional Dumpster Rental Support You Need
While you might have arrived at the conclusion that you have to rent a dumpster, you might have no idea how to do so.
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Renting a dumpster in El Cajon, CA will be effortless if you call Dumpster Deliveries.
- Simply just call our phone number 888-371-6897
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Booking a dumpster is not cheap. If you have no experience concerning this, you could end up spending even more than you ought to.
- Compare rates from a variety of companies When comparing prices, be sure you are comparing dumpsters of the same size.
- Ensure you understand what size you need so that you don't get a larger size. At Dumpster Deliveries we will guide you to determine your size also.
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If you comply with these tips, you'll save on expenses when booking your dumpster rental from Dumpster Deliveries in California. Just before calling 888-371-6897 for your dumpster rental, you should definitely read these tips and recommendations.


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It sucks being young, male, and single. Shortly after the soldiers from 4th Squadron, 73rd Cavalry Regiment set out on patrol from Strong Point Payenzai, Afghanistan, a motorcycle carrying three Afghan men came into view. Check us out at our new home on BostonGlobe. Global War on Terrorism. Can cancel at this is time i was already?
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ISLAMABAD – People on social media are talking about the leaked plans of Indian spy agency Research and Analysis Wing (RAW) which were about giving opportunity to TTP to attack on security forces.
Social media users believe that RAW was involved in the attacks over rangers to support the TTP. Pakistan army had launched a country wide operation against militants. At the same time Rangers had been attacked by Border Security Forces.
People believe that it was the plan of RAW to engage Pakistan Army over Eastern Border.
A guy tweeted that
#RAWPlansLeaked We will never forget how India killed our people pic.twitter.com/9aZ37Wh3Fh
— Farhan Khan Virk (@FarhanKVirk) February 7, 2015
Another tweet was about RAW's plan in Baramula Occupied Kashmir
#RAWPlansLeaked RETWEET This top secret RAW document, India plans to attack Kashmir in Mujahideen dress pic.twitter.com/70BhKwPaqb — Farhan Khan Virk (@FarhanKVirk) February 7, 2015
A girl highlighted the presence of Indian counulates in Afghanistan at Pakistan border. Th ecousulates should be located in populated areas and big cities as per international law.
"@Huzefa1983: 30 Indian Consulates in just KUNAR Province show real designs of Indian Sponsored Terrorism in Pakistan #RawPlansLeaked"
— Sharmeenkashif (@Sharmeenkashif) February 7, 2015
She continued
India continuously killing innocent ppl in Kashmir where is our Govt. ?? #RAWPlansLeaked pic.twitter.com/ZwuFL3QdY1 — Sharmeenkashif (@Sharmeenkashif) February 7, 2015
Do you have information you wish to share with PakistanTribeCom? Email our News Desk to share news tips, reports and general feedback. You can also email the Blog Desk if you have an opinion or narrative to share. Follow PakistanTribe on Twitter Follow @PakistanTribe and Join us on Facebook


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Today we'd like to introduce you to Julie Martin.
Scout Mandolin is a luxury brand that makes custom one of a kind engagement rings, wedding bands and fine jewelry. Scout Mandolin is intentionally evocative of past, present and future. 'Scout' is the soft, precise search for love manifest in design – the search for who he or she is and what makes him or her unique; 'Mandolin' is the allegorical essence of the sweet country melodies that captured Julie's imagination as a girl growing up in the south. Design and create the finest quality custom engagement rings and jewelry, cut out the middle men to save their clients time and money, provide socially conscious diamonds that are the very best value and quality and use their innovative custom design process and decades of experience to help their clients capture the essence of their one true love.
Founder, Julie, graduated with a B.A. in Applied Arts and Sciences with an emphasis in Jewelry and Metals. Followed by an apprenticeship with two master jewelers that are now part of the Scout Mandolin team. She started a fashion jewelry company with her pieces selling in hundreds of locations around the world. A decade later, she sold her fashion jewelry company, following her passion for creating one of-a-kind custom engagement rings and fine jewelry. Scout Mandolin is this next chapter.
Julie's vision of transforming the way custom engagement rings and jewelry are created has come to life in Scout Mandolin where her bespoke design process captures the art of love. They take the guess-work out of the process by giving he or she a platform to say what they want, while preserving the element of surprise.
Scout Mandolin takes the guess-work out of engagement ring shopping by creating a one-of-a-kind ring for your one-of-a-kind love.
They want this to be a smooth and enjoyable experience. This is where dreams are designed and capturing every facet of your special someone is their #1 goal.
Overall, has it been relatively smooth? If not, what were some of the struggles along the way?
The road is never smooth – and that represents both the challenge and the excitement. Twain wrote, "Twenty years from now, you will be more disappointed by the things you didn't do than by the ones you did do, so throw off the bowlines, sail away from safe harbor, catch the trade winds in your sails. Explore, Dream, Discover." I think of that often. I like that because it reminds me the road isn't supposed to be smooth. Entrepreneurship is about navigating far and away; it takes courage. When I move along, it makes me feel stronger. The struggles along the way were many: how best to build, design, manage, and scale a business? …And how to do this while holding together some sort of a personal life? I wrestle mostly with the intersection of my art and my business. It's a tension I feel daily. But I do feel that I am my best in that struggle – out at sea, so to speak, far from safe harbor. Entrepreneurs were meant to be at sea. Twain was right, I think.
Scout Mandolin – what should we know? What do you guys do best? What sets you apart from the competition?
By listening to your love story and learning all of the details about your special someone. Discovering these details will allow us to capture a robust profile that inspires your design. Your custom piece with your love story, his or her tastes, and your budget in mind! We create incredible value by eliminating the retail middle man and by not keeping an inventory of diamonds in house. Throughout this exciting design process, we serve as your personal guide and remove all of the worry and stress so you can enjoy being a part of such a meaningful expression of your love. Truly one of a kind custom engagement rings and jewelry. Our creative design process deliberately empowers each partner to play a part, preserving the balance between the necessity of their input with the magic of your surprise!
Scout Mandolin's master jewelers are an integral part of your custom design journey from start to finish. With more than 75 years behind the bench, their expert craftsmanship and attention to the finest detail is absolutely unparalleled ensuring your creation is the finest quality imaginable
What is "success" or "successful" for you?
Success for me is simple: Am I healthy of body, heart and mind, being creative, contributing to others in a meaningful way, and taking risks. I am at my best when I'm pushing the body-mind-spirit thing. Success is having the confidence each day to take the chance on my creativity, my dreams. Total and complete belief in myself. I'm not there yet – who really is? – but I work on it every day.
Being autonomous, creative and helpful to others sounds a lot like perfect success to me.
Contact Info:
- Address: 861 Sixth Avenue #311
San Diego, CA 92101
- Website: www.scoutmandolin.com
- Phone: 8585313455
- Email: firstname.lastname@example.com
- Instagram: https://www.instagram.com/scoutmandolin/
- Facebook: https://www.facebook.com/scoutmandolin/
- Twitter: https://twitter.com/scoutmandolin
- Yelp: https://www.yelp.com/biz/scout-mandolin-san-diego-2
- Other: https://www.theknot.com/marketplace/scout-mandolin-napa-ca-1054754
Image Credit:
Diamond Foundry
Scout Mandolin
Getting in touch: SDVoyager is built on recommendations from the community; it's how we uncover hidden gems, so if you know someone who deserves recognition please let us know here.


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Ospanov Galym, actor
He was born in 1991 in v. Bozkol Kazaly district of Kyzylorda region.
In 1998 – 2009 he studied at school №16 named after S. Seifullin, in the village Teris, district Zhualy of Zhambyl region.
In 2009 -2013 graduated from "theatrical" department of Kazakh National Academy of Arts named after T. Zhurgenov, by profession "actor of the dramatic theatre".
Since 2013 actor of the academic drama theatre named after M. Auezov.
The main roles: Kalmyk bek in drama "Tansulu" by G. Esim (dir. E. A. Kakisheva), Tybalt in "Romeo and Juliet" by W. Shakespeare (dir. O. Salimov), Senate employee in "Othello" (dir. N. Ptushkina), Don Cesar de Bazan in "Spanish nobleman" by Ph. Dumanoir and A. d'Ennery (translated and directed by A. Rahimov), Lawyer in criminal drama "Accused of murder" – author I. Vovnyanko (dir. A. Ashimov, S. Askarov) and others.
An actor with a brilliant voice sings songs and spark off in performances, as well as presenter /anchorman/ of big concerts.


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Today, I came across the absolute best commercial EVER. It baffles me that this isn't a SuperBowl commercial. lol I've already watched this multiple times because as a mother, it just warms my heart. Why? Because the child in this video reminds me so much of our 2nd son, Zachary.
You see, our 2 older boys LOVE anything to do with Star Wars. But I swear, it is Halloween year round for Zachary. He is constantly in costumes, dressing up as Darth Vader, Storm Troopers, Army Men, Spiderman, you name it. Come summertime and you'll see him and Justin running around outside with swords, shields and pretend laser guns to fend off the bad guys.
Put your speakers on and enjoy.


text: Are you ready for some period-accurate, racially charged football? AMC is developing a series adaptation of The Real All Americans, Sally Jenkins' story of the famed football program at Pennsylvania's Carlisle Indian Industrial School, and all of its rowdy, personally invested friends are coming over. Namely actor Tommy Lee Jones, whose Cherokee ancestry and background as an offensive tackle for Harvard have made him AMC's preferred candidate to direct the story of U.S. cavalry officer Richard Henry Pratt's 1879 journey into the heart of the Dakota Territory, where he recruited the Native American team that would wage symbolic war on the field against their Ivy League oppressors—a war that presumably rages on inside Jones' very DNA, which may be why he's always making that face. Should it go forward, the series would become the network's second post-Civil War drama dealing with racial issues next to the coolly received Hell On Wheels, though All Americans has the added bonus of (eventually) including the early stories of revered athlete Jim Thorpe and coach "Pop" Warner, potentially promising a broader audience. But fewer prostitutes, probably.