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Thanks for your interest in MailChimp Zf2!
I'm currently working on a detailed video to get you the latest information on this…
But in the meantime…
Checkout the best ClickFunnels offers, benefits, and features below.
In this day and also age, the method your organisation runs online can make or break you.
How do most companies presently have a visibility online?
The truth of the matter is, nevertheless, that web sites have actually dramatically progressed over the past years – as well as the methods of old are no more useful for modern organisation.
In the past, it would suffice to have a basic site with a web page, services, pricing, regarding us, and contact web pages.
A potential customer would go to your website, scroll about, go to the various web pages as well as consume material as they please.
Nevertheless, if you are a company spending any kind of loan on advertising, you wish to control exactly what clients are finding out about on your website, present deals at the right time, and take full advantage of the profits you make from each person.
Exactly how does one accomplish this?
Making use of sales funnels.
Enter ClickFunnels
ClickFunnels is the easiest means to make high converting sales as well as advertising and marketing funnels.
It is a special tool developed especially to turn potential clients into customers.
It really is an all-in-one option to create sales funnels as well as includes landing web pages, email integration, billing, webinars, subscription websites, therefore far more. No wonder it has rapidly become a favored device for marketing experts.
Below is my comprehensive ClickFunnels Evaluation, including preferred features, pricing, pros/cons, and contrasts against competitors.
MailChimp Zf2: Yet First, Exactly What Is a Sales Funnel?
Sales funnels (also called marketing funnels) are multi-step projects that are designed to move potential leads with your sales procedure, as well as turn them right into purchasers.
Image a real-life funnel. At the top, you put fluid in, which limits to one repaired location.
In sales, a similar occasion occurs. At the top, site visitors come to your website, but not all who go into make it from the other end as buyers.
Numerous things have to happen from the moment a site visitor enters your channel, to the time they do something about it as well as successfully complete a purchase.
By breaking down the customer's trip into smaller sized steps, you can be a lot more exact about how when you provide an offer to your audience.
The thorough action in a funnel might look something such as this:
- Unqualified lead comes to touchdown page
- Web page communicates the very first deal (something free to gather an email).
- As soon as email is collected, major offer is pitched.
- Lead becomes a paying client.
- More email communication supplying customer value.
- More partnership structure
- Recurring sales.
ClickFunnels likewise has a visuals that discusses this in an easy method:.
Just what is ClickFunnels?
As stated previously, ClickFunnels is the very best sales channel software application around today.
The company makes the vibrant insurance claim of giving you everything you have to market, sell, and deliver your products online – and also they most definitely deliver.
A conventional funnel will certainly utilize an opt-in web page (to accumulate email addresses), an email auto responder (to send out e-mails to your consumers), plus an added sales web page with some web content as well as an order type, potentially complied with by extra material, a membership website, etc
. Previously, you would certainly have to make use of different systems as well as devices to complete all of these tasks such as:
- Develop a web site
- Find Hosting
- Locate an autoresponder service
- Discover membership website software application
- Find split-testing software application … and so on
But ClickFunnels takes care of every little thing with their system. You not only conserve a ton of cash by not needing to purchase different products/services, but you likewise prevent the technical mess of having to set everything up, and could focus on just what's truly important – growing your company.
ClickFunnels offers a Free 14-Day Trial, so you reach discover the device and also really see if it's best for your service.
Preferred Functions
* Promptly Create Pages Using Templates and also Components *.
Prior to obtaining as well far, it is very important to comprehend that a channel is a collection of pages put together in a strategic order, with the goal of converting as many potential customers into customers. And also a page is just a collection of numerous aspects developed to get a person to take a specific activity.
ClickFunnels supplies more compared to 50 various aspects to help you develop the ideal page. The editor is very very easy to make use of as well as all you have to do is drag as well as drop different elements on the web page, and also update the message and appearance to fit your needs – no coding skills called for!
ClickFunnels likewise makes your life less complicated by providing you with a ton of totally free templates.
In fact, ClickFunnels offers over 37 sorts of pages for you to mix and also match with. These are damaged down right into the complying with 10 categories:
- Presell Pages: Study Page, Article Web Page, Presell Page, Clickpop Web Page
- Optin Pages: Squeeze Web Page, Reverse Press Page, Lead Magnet, Discount Coupon
- Thank You Pages: Thank You Web Page, Offer Wall, Bridge Web Page, Share Web Page
- Sales Pages: Video Sales Web Page, Sales Letter Page, Item Launch Page
- OTO Pages: Upsell Web Page, Downsell Web Page
- Order Forms: Two Step Order Page, Traditional Order Web Page, Video Sales Letter Order Page, Sales Letter Order Page, Product Launch Order Page
- Webinar Pages: Webinar Enrollment Web Page, Webinar Verification Web Page, Webinar Program Room, Webinar Replay Area
- Subscription Pages: Access Web page, Member's Location
- Affiliate Pages: Access Page, Affiliate Area
- Other Pages: Application Web Page, Ask Page, Store Front, Home Page, Hero Page, Hangout Page, Live Demonstration Page
The pre-built themes are completely adjustable, as well as are exactly what most customers utilize.
You are able to choose a template, modify or change the elements with your very own, and your brand-new web page prepares to go.
You could likewise connect any channel you develop with your own email advertising and marketing service (if you don't use the one included in ClickFunnels), and also use the ClickFunnels built in billing system.
This is also a blast to state that ClickFunnels offers very helpful as well as easy to understand training videos when you initially register. I extremely suggest undergoing those due to the fact that they quickly enable you to utilize the device at its complete ability, as well as you'll have much more enjoyable playing around. MailChimp Zf2
* Produce One-Click Subscription Websites *.
One of the most effective attributes with ClickFunnels is the ability to easily develop subscription websites as well as supply material to your audience in one place.
Your subscription site will come total with enrollment pages, membership gain access to pages, and also web content web pages which you could conveniently lock or leak feed to your clients inning accordance with purchases they made in your channel.
ClickFunnels membership websites allow you to send out e-mails, easily handle your emails, as well as construct an area all while eliminating the tension that's connected with various other remedies such as Kajabi, or WordPress systems.
It's really convenient to not have to purchase a separate software or plugin to develop subscription websites.
* Email Combination & Actionetics *.
With every channel comes email listing building opportunities.
ClickFunnels supports e-mail integration with every one of the significant e-mail automation platforms such as:
- Active Campaign
- Aweber
- Constant Contact
- ConvertKit
- Drip
- Get Response
- Hubspot
- InfusionSoft
- Mad Mimi
- MailChimp
- Market Hero
- Ontraport
- Salesforce
- Sendlane
- And others
However, ClickFunnels also has their own effective automation tool called Actionetics.
Although you could create, schedule, as well as deliver e-mails as with other e-mail marketing system, Actionetics is so much extra.
I like Actionetics due to the fact that it not only replaces your email advertising however messenger advertising and marketing as well as SMS advertising and marketing software applications as well. This takes automation to a whole brand-new level and also helps you communicate the perfect message to your customers, specifically when they require it. A video summary of Actionetics will certainly be given better listed below.
* Invoicing as well as Repayment Assimilation *.
A remarkable function within ClickFunnels is the capability to gather all the payment information from your consumers precisely your sales page. Offering is made so much simpler when customers don't have to leave your site.
ClickFunnels integrates with significant payment gateways such as PayPal, Stripe, and InfusionSoft, to name a few.
ClickFunnels Prices.
While you could start with the Free 14-Day Trial, there are three various pricing choices with ClickFunnels:
- $ 97/month.
- $ 297/month.
- $ 997 bulk discount rate plan (recommended).
I'll explain for each of these strategies listed below.
1. ClickFunnels Requirement Strategy – $97/month.
The conventional strategy consists of all the features you would certainly need within ClickFunnels, but with limitations on the variety of funnels (20) as well as pages (100) you could have in your account, as well as how many site visitors (20K) can watch your pages monthly.
You also do not get innovative functionality such as ClickFunnels very own e-mail advertising and associate tracking tools.
2. ClickFunnels Etison Suite – $297/month.
This plan consists of all the bells as well as whistles of the standard strategy, with no limitations. It likewise includes 2 added products generated by ClickFunnels called Actionetics (email marketing) as well as Backpack (associate monitoring platform).
In Actionetics – you can manage all of your calls that sign up for your list, send e-mail programs, and also create a host of other automations. MailChimp Zf2
The distinction between both strategies really is the limitations, and also Actionetics/Backpack. If you are a basic user and don't anticipate to make use of greater than 20 funnels in your account – the Criterion Strategy should be adequate.
Nevertheless, if you intend to have an affiliate program or want to keep your e-mail advertising within ClickFunnels and also not utilize a 3rd party software program, the Etison Suite is for you.
You could constantly start on the lower strategy and also upgrade if required.
3. Funnel Hacks System – $997
For any person that's significant regarding their organisation, the ClickFunnels Funnel Hacks System is the deal of the century.
The $997 Funnel Hacks System includes durable training programs bundled with 6-month accessibility to the ClickFunnels Etison Collection.
This is an amazing bargain since beyond this program, 6-months of Etison Collection alone would certainly cost you $1782.
Not only are you saving $785 yet you're getting a lots of trainings as well as overviews of aid you get one of the most from ClickFunnels!
ClickFunnels Advantages And Disadvantages
- Creating funnels is extremely simple, simple, and also fast
- All-in-one platform with whatever your business should win
- Split testing and conversion monitoring consisted of
- Email combination with all of the major email autoresponder systems
- Repayment processing abilities within ClickFunnels
- ClickFunnels is constantly adapting as well as updating to the moments
- There is constantly support offered (whether real-time or otherwise).
- Incredibly energetic Facebook Group Neighborhood.
- Free 14-Day Trial – enables you to try it risk complimentary.
- As incredible as ClickFunnels is, it definitely is not a low-cost option and also needs a continuous subscription to make use of
- Assistance isn't really constantly the fastest as well as might draw from 1 minute to 24 Hr depending upon the problem.
ClickFunnels versus Every person Else.
Many individuals ask exactly how ClickFunnels compares to various other landing web page building contractors such as Leadpages, Unbounce, and also Infusionsoft.
For the most part it's not actually a reasonable comparison since each of these tools stands out is one area or the other.
The chart above provides a complete analysis – however I'll highlight some of the significant contrasts listed below.
ClickFunnels vs Leadpages
Prior to ClickFunnels, Leadpages was the huge pet.
Leadpages is just a lead capture software application – nothing more. You could develop landing pages, lead boxes, gather leads … that's virtually it. Furthermore, the Leadpages themes are additionally restricted on customization.
ClickFunnels is much more versatile – it's a lot easier to make use of as well as does so a lot more compared to create lead capture pages.
Simply put, Leadpages is truly simply a touchdown web page building contractor, while ClickFunnels is focused around developing highly incorporated funnels.
ClickFunnels vs Infusionsoft
Infusionsoft is not a landing web page or sales page building contractor. It has a few of that performance constructed it, however that's not just what it's known for.
At it's core, Infusionsoft is a CRM system – one that allows you to handle your whole client database. ClickFunnels has this ability with Actionetics, however it's not virtually as advanced as Infusionsoft.
Infusionsoft is also very pricey and also pressures every new consumer to pay $2000 for a mandatory kickstart training plan simply to find out the best ways to make use of the complicated system (which is infamously challenging to make use of).
ClickFunnels Associate Program
There are 2 major paths people drop as ClickFunnels individuals.
Those that prefer to use the tool for their service – in hopes of one day achieve the Two Comma Club (over $1M in profits).
And those that want gaining passive revenue as a ClickFunnels Affiliate and winning the Dream Car Contest (where they pay $500/$1000 in the direction of your dream car if you get to 100/200 energetic regular monthly signups, respectively).
With a monstrous 40% monthly persisting compensation, ClickFunnels easily has among the best associate programs of any system out there.
That's right – you earn money a recurring 40% compensation on every affiliate signup you make via the ClickFunnels Affiliate Program. But, exactly what does that truly correspond to?
The standard strategy is a $97/month financial investment and the Etison Collection plan is a $297/month financial investment. consequently you make $38.80 each standard plan and $118.80 per Etison Collection plan … every single month!
Typically, every 100 signups will certainly generate $4000/month in associate compensations (essentially relying on the number of Etison Plan individuals are in there).
Go here for more information regarding becoming a ClickFunnels Affiliate.
All-time Low Line
ClickFunnels is pass on the greatest platform if you are looking to conveniently construct high transforming sales funnels.
Because it was built from scratch to be the very best sales funnel contractor, it vanquishes every one of the competition in that regard.
Externally, it might not be the most affordable item around – yet if you use it to its full capacity, your organisation will come to be much more profitable and you will certainly conserve loan from not needing to use various other devices. MailChimp Zf2
If you have actually read this much right into my ClickFunnels Testimonial, I advise you see on your own with a Free 14-Day Trial here.


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Updated: November 05, 2019 08:06 AM
It's an effort to get candy to some deserving individuals.
If your kids have any extra Halloween candy lying around, you can donate to U.S. troops serving overseas.
All you have to do is drop it off at an M Health Fairview or U of M Physicians clinic, and in exchange for it, kids will get a free book.
The project brought in 2,000 pounds of candy last year.
Donations are being accepted through Friday.
Updated: November 05, 2019 08:06 AM
Published: November 04, 2019 12:00 AM
Copyright 2019 - KSTP-TV, LLC A Hubbard Broadcasting Company

subset: commoncrawl


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Vivienne Thorneycroft-Smith
Registered Member MBACP (Senior Accredited)
Contact information
- Phone number
- 07907 632827
Therapist - FARNHAM COMMON
07907 632827
Sessions from £50.00
About me and my therapy practice
I am a Senior Accredited therapist, with 18 years of wide-ranging experience, which has proved to be effective and successful in short and long-term therapy. 'Sometimes all it takes is one small step to make big changes'. www.Changes-Counselling.co.ukhttps://www.youtube.com/watch?v=OoSLjiAxuJI
What I can help with
Abuse, Anger management, Anxiety, Bereavement, Cultural issues, Depression, Eating disorders, Loss, Personal development, Redundancy, Relationships, Self esteem, Self-harm, Stress, Work related issues
Clients I work with
Adults, Couples, EAP, Groups, Young people
How I deliver therapy
Long-term face-to-face work, Short-term face-to-face work


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Leprosy is a chronic and debilitating human disease caused by infection with the Mycobacterium leprae bacillus. Despite the marked reduction in the number of registered worldwide leprosy cases as a result of the widespread use of multidrug therapy, the number of new cases detected each year remains relatively stable. This indicates that M. leprae is still being transmitted and that, without earlier diagnosis, M. leprae infection will continue to pose a health problem. Current diagnostic techniques, based on the appearance of clinical symptoms or of immunoglobulin M (IgM) antibodies that recognize the bacterial phenolic glycolipid I, are unable to reliably identify early-stage leprosy. In this study we examine the ability of IgG within leprosy patient sera to bind several M. leprae protein antigens. As expected, multibacillary leprosy patients provided stronger responses than paucibacillary leprosy patients. We demonstrate that the geographic locations of the patients can influence the antigens they recognize but that ML0405 and ML2331 are recognized by sera from diverse regions (the Philippines, coastal and central Brazil, and Japan). A fusion construct of these two proteins (designated leprosy IDRI diagnostic 1 [LID-1]) retained the diagnostic activity of the component antigens. Upon testing against a panel of prospective sera from individuals who developed leprosy, we determined that LID-1 was capable of diagnosing leprosy 6 to 8 months before the onset of clinical symptoms. A serological diagnostic test capable of identifying and allowing treatment of early-stage leprosy could reduce transmission, prevent functional disabilities and stigmatizing deformities, and facilitate leprosy eradication.
Cases in which Mycobacterium leprae infection manifests to cause leprosy present as a bacteriologic, clinical, immunologic, and pathological spectrum ranging from the extremes observed in paucibacillary (PB) and multibacillary (MB) patients (21, 24). PB patients have one or a few skin lesions and a low or absent bacterial index (BI; a measure of the number of acid-fast bacilli in the dermis, expressed on a logarithmic scale) and demonstrate specific cell-mediated immunity against M. leprae, but they have low or absent titers of M. leprae-specific antibodies and a granulomatous dermatopathology. In marked contrast, MB patients have multiple symmetric skin lesions and a high BI and demonstrate high titers of anti-M. leprae antibodies but an absence of specific cell-mediated immunity and a dermatopathology largely devoid of functional lymphocytes (21). Despite the implementation of a WHO-directed eradication program over the last 20 years, the worldwide annual rate of new case detection for leprosy remains stable at approximately 300,000 (17, 18, 26, 27). Earlier and objective diagnosis of leprosy could interrupt transmission and, in the long term, help further reduce the number of new cases and facilitate eradication.
There is no single diagnostic laboratory test for leprosy, and diagnosis remains essentially clinical. Clinical diagnosis of leprosy is dependent upon recognition of disease symptoms and is therefore only possible once the disease has manifested. WHO experts have listed diagnostic criteria as one or more of the following: hypopigmented or reddish skin patches with definite loss of sensation; thickened peripheral nerves; acid-fast bacilli on skin smears/biopsy specimens (WHO Expert Committee on Leprosy, 1998). Pure neuritic leprosy forms, however, present with no skin lesion. Confounding WHO's implementation of a global leprosy eradication strategy is that the number of trained leprologists has diminished. This is inadvertently increasing the likelihood that a clinical diagnosis is delayed or even missed, especially in regions where leprosy has been controlled (1, 13, 16, 25).
The presence of serum immunoglobulin M (IgM) antibody to phenolic glycolipid I (PGL-I) correlates with BI in leprosy patients and has been used to support disease symptoms as a means to categorize leprosy patients. Enzyme-linked immunosorbent assay (ELISA) and rapid lateral flow test formats have been developed for the detection of anti-PGL-I antibody (3, 4, 8, 19, 22, 23, 28). In one study, a lateral flow assay correctly diagnosed 97.4% of MB patients, with a specificity of 86.2% (4). Patients toward the PB end of the leprosy spectrum have low or no BI, however, and the majority of these patients are not identified by PGL-I-based tests (4, 7, 19). In addition, false-positive results in areas of endemicity are relatively high (>10%) (4, 7, 19). Consequently, none of these PGL-I-based tests has been widely implemented in field situations. In addition, many studies have demonstrated that MB patients have high titers of M. leprae-specific antibodies but PB patients have low or absent titers. For these reasons, the potential for serological diagnosis of low-BI patients, such as PB patients or MB patients who are developing disease, has not been thoroughly pursued.
In a recent small-scale study, we demonstrated that the ML0405 and ML2331 proteins were recognized by sera from MB leprosy patients presenting with high BI (20). In the current study we demonstrate that ML0405 and ML2331 are diagnostically relevant antigens by analyzing a large panel of MB leprosy patient sera from a variety of leprosy-affected regions (the Philippines, central and coastal Brazil, and Japan). We also examine the ability of M. leprae protein antigens to diagnose low-BI leprosy (PB patients and early MB patients) and show here the diagnostic potential of ML0405, ML2331, and a newly discovered M. leprae antigen, ML1556c. Based on the results, we construct and evaluate a fusion protein comprising ML0405 and ML2331 (designated leprosy IDRI diagnostic 1 [LID-1]) and demonstrate that this construct can be used to serologically diagnose leprosy patients among presymptomatic individuals, that is, before a clinical diagnosis is possible. Moreover, ML1556c may be a valuable adduct to LID-1 for the diagnosis of PB leprosy.
Subjects and samples.Sera were obtained from patients with leprosy (MB and PB) or tuberculosis (TB), healthy household contacts of MB leprosy patients (HHC), and endemic and nonendemic controls (EC and NEC). MB and PB leprosy patient sera used in this study were derived from recently diagnosed, previously untreated individuals who did not have signs of reversal reactions. Leprosy was classified in each case by bacterial, histological, and clinical observations carried out by qualified personnel, with the BI recorded at the time of diagnosis. HHC were defined as adults living in the same house as an MB index case for at least 6 months. TB patients were included to evaluate potential antigen cross-reactivity with other mycobacterial infection. Sera from TB patients were obtained after drawing blood from Mycobacterium tuberculosis sputum-positive, human immunodeficiency virus-negative individuals with clinically confirmed pulmonary TB who were undergoing treatment. Normal sera (EC and NEC) were obtained after blood draws from volunteers with no history of leprosy or TB infection. In all cases, drawing of blood was carried out with informed consent (with local institutional review board approval or local ethics committee approval in Brazil, Japan, the Philippines, Seattle, and St. Louis). The composition of each study population is summarized in Table 1.
In Cebu City, leprosy and TB patients were recruited at the Cebu skin clinic and Leonard Wood Memorial Research Center in Cebu City, Cebu (Philippines) from 2003 to 2006. Between 1985 and 1991, sera were collected prospectively from individuals who resided with MB patients (BI > 2) for at least 2 years and were free of leprosy as determined by clinical dermato-neurological examination at the inclusion point of the study. Some of these individuals developed MB leprosy as the study progressed, and these sera have previously been described (11).
In Goiânia, the state capital of Goiás State (western central Brazil), leprosy and TB patients were recruited at the main outpatient clinics of Centro de Referência em Diagnóstico e Terapêutica and Hospital Anuar Auad in 2006. PB leprosy patients were selected from a cohort of leprosy patients with a single skin lesion recruited at Brazilian sites of endemicity from 1999 to 2001, as previously described (9).
In Salvador, the state capital of Bahia State (northeast coastal Brazil), leprosy patients were recruited at Hospital Dom Rodrigo de Menezes in 2006.
In Japan, leprosy patients were recruited at the National Sanatorium Oshimaseishoen, Kagawa.
In St. Louis, sera were collected from U.S.-based individuals at a variety of times following Mycobacterium bovis BCG immunization.
All serum specimens were aliquoted and stored at −20°C or −80°C prior to assay.
Cloning and purification of target antigens.DNA encoding selected M. leprae proteins was PCR amplified from M. leprae Thai-53 genomic DNA using Pfx DNA polymerase (Invitrogen, Carlsbad, CA). PCR primers were designed to incorporate specific restriction enzyme sites 5′ and 3′ of the gene of interest and excluded in the target gene for directional cloning into the expression vector pET28a (Novagen, Madison, WI). After PCR amplification, purified PCR products were digested, ligated with vector DNA, and used to transform Escherichia coli, and individual clones were induced to produce recombinant proteins, as previously described (20). Recombinant proteins were quantified using the bicinchoninic acid protein assay (Pierce, Rockford, IL), and quality was assessed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The characteristics of each M. leprae protein evaluated are summarized in Table 2. The ML1556c protein was included because portions of the ML1556 protein were identified in four separate clones during serological expression screening with sera from PB leprosy patients (data not shown) (20). Recognition of the clones was derived from amino acids 58 to 256 of ML1556, which are only 47% identical to the M. tuberculosis protein Rv2839 (compared to 82% identity across the entire amino acid sequences of ML1556 and Rv2839).
Determining patient reactivity by ELISA.ELISAs were conducted independently at IDRI, Seattle, WA (Cebu and St. Louis sera); UFG, Goiânia, and UFB, Salvador, Brazil; and NIID, Tokyo, Japan. Polysorp 96-well plates (Nunc, Rochester, NY) were coated with 1 μg/ml recombinant protein or 200 ng/ml of natural disaccharide with octyl linkage (NDO), the synthetically derived B-cell epitope of PGL-I, conjugated to bovine serum albumin (NDO-BSA; kindly supplied by John Spencer, Colorado State University, under NIH contract N01 AI-25469), in bicarbonate buffer overnight at 4°C and blocked for 1 h at room temperature with phosphate-buffered saline-Tween with 1% BSA on a plate shaker. Serum diluted appropriately in 0.1% BSA was added to each well, and plates were incubated at room temperature for 2 h with shaking. Plates were washed with buffer only, and horseradish peroxidase-conjugated IgG or IgM (Rockland Immunochemicals, Gilbertsville, PA), diluted in 0.1% BSA, was added to each well and incubated at room temperature for 1 h with shaking. After washing, plates were developed with peroxidase color substrate (Kirkegaard & Perry Laboratories, Gaithersburg, MD), and the reaction was quenched by the addition of 1 N H2SO4. The optical density (OD) of each well was read at 450 nm. Positive responses were defined as an OD of >2× the mean OD of endemic control sera or an OD of >0.1, whichever was higher.
Statistics. P values were determined using Student's t test.
Recognition of M. leprae proteins by Filipino leprosy patient sera.The majority of MB leprosy patients are readily identified by ELISA and lateral flow tests, which assess the capacity of patient IgM to bind M. leprae PGL-I or its synthetic analogue (NDO) conjugated to a carrier protein (BSA). In comparison with MB leprosy patients, PB leprosy patients have low or no anti-PGL-I responses and are more difficult to diagnose serologically. We therefore sought to determine whether PB sera recognized protein antigens, expanding our previous analyses and comparing the potential of NDO-BSA, ML0405, and ML2331 to diagnose leprosy, and found that the protein antigens have a similar profile for leprosy diagnosis as that for NDO-BSA; all three test antigens were readily detected by MB patient sera, by some PB patient sera, and by few, if any, EC, HHC, or TB sera (Fig. 1). Thus, similar to NDO-BSA, ML0405 and ML2331 demonstrate good potentials for the diagnosis of leprosy.
Recognition of MB leprosy patient sera with refined ML0405 antigen constructs.To learn more regarding the seroreactivity of ML0405 and enhance recombinant ML0405 expression for purification, we expressed a variety of ML0405 polypeptide fragments and determined whether Filipino MB leprosy patient sera had similar binding capacities to these fragments and to full-length (ML0405FL) protein. All constructs were able to bind MB patient sera (Fig. 2) (P < 0.01 for MB versus EC). The reactivity of a truncated form (ML0405Tr) of the protein was equivalent to the reactivity of ML0405FL (P = 0.885 for MB patient sera), whereas the reactivity of the protein construct lacking the predicted membrane-spanning region (ML0405Tm) declined slightly (Fig. 2) (P = 0.047 and 0.060 for Tm versus FL and Tr forms, respectively, for MB). These data indicate that the majority, if not all, of the B-cell epitopes recognized by antibodies in patient sera are retained and accessible in the truncated form of the protein. Further testing was conducted using either ML0405FL or ML0405Tr.
Diagnosis of Filipino PB leprosy patients with M. leprae proteins.We then went on to more closely investigate the potential of M. leprae antigens for diagnosing PB leprosy. Sera from Filipino patients clinically diagnosed with PB leprosy and with a low BI were tested for reactivity with potential diagnostic M. leprae antigens (ML0405Tr, ML2331, ML1556c, and NDO-BSA). NDO-BSA was capable of identifying 57% (26 of 46) of these Filipino PB leprosy patients, but a substantial number of samples provided weak positive responses (Fig. 3). ML0405 and ML2331 also reacted with sera from some PB patients (Fig. 3A and B). Most of these Filipino sera that reacted with these proteins also demonstrated strong NDO-BSA responses, however, and so the added benefit of using these antigens for leprosy diagnosis within the Filipino population appeared minimal. In contrast, 4 of 20 sera that were weak positive/negative by NDO-BSA ELISA testing demonstrated strong reactivity to ML1556c (Fig. 3C). This result suggests that ML1556c may be useful as an adjunct to PGL-I testing, or other tests, to improve the sensitivity and clarity of leprosy diagnosis.
To test the specificity of ML1556c as a leprosy diagnostic reagent, we directly compared the reactivities of ML1556c with sera from PB leprosy patients, MB leprosy patients, TB patients, EC, and HHC of MB leprosy patients located in Cebu City, Philippines (Fig. 3D). Positive responses were observed in five of eight additional PB leprosy sera tested, with three of the sera yielding strong responses that could provide a clear diagnosis. Positive responses to ML1556c were also observed in two of seven MB leprosy sera tested in this experiment. ML1556c did not react with any of the Filipino TB patient sera tested, was recognized by only one of eight HHC sera, and reacted with only one of six EC sera. Negative results were obtained upon further testing involving another 45 TB sera and 23 NEC sera (data not shown). Taken together, these results generated from sera from the Philippines suggested the utility of ML1556c to improve the diagnosis of PB leprosy.
Identification of leprosy patients in Brazil.We also examined the ability of recombinant M. leprae antigens to identify leprosy patients located around Goiânia, Brazil, and Salvador, Brazil. Within the clinically diagnosed leprosy population, PGL-I/NDO-BSA was capable of identifying 87% (33 of 38) of the MB patients (Fig. 4). In agreement with the results obtained by analysis of Filipino leprosy patient sera, ML0405 and ML2331 reacted with large proportions of Brazilian MB patient sera (87% [33 of 38] and 76% [29 of 38], respectively), and ML1556c reacted with only some MB patient sera (13%, 5 of 38) (Fig. 4). In Goiânia, positive responses were also observed against antigens ML0091 (71%, 20 of 28), ML1633 (32%, 9 of 28), ML2055 (75%, 21 of 28), and ML2346 (29%, 8 of 28) (data not shown). The clarity of MB leprosy diagnosis (strength of signal in positive samples versus negative samples) in Goiânia was greater when using ML0405 rather than NDO-BSA, but in Salvador it was greater when using ML2331 rather than NDO-BSA.
We also determined if these antigens were recognized by Brazilian PB patient sera. PGL-I/NDO-BSA was capable of identifying only 20% (18 of 89) of the PB patients, a level not appreciably higher than the proportion of positive responses observed with TB patients (12%, 3 of 26) (Fig. 4A). An IgG reactivity that permitted serologic diagnosis of an increased number of PB leprosy patients was observed for ML0405 (69%, 61 of 89), but responses to ML2331 were very weak, with very few positives (3%, 3 of 89) (Fig. 4A). The antigens ML0091 (6%, 5 of 83), ML1633 (17%, 14 of 83), ML2055 (13%, 11 of 83), and ML2346 (27%, 22 of 83) were recognized by some PB patient sera, but responses were generally weak (data not shown). Many of the PB patient sera that did not react with PGL-1 had a strong reactivity with ML0405 (Fig. 4B). ML1556c was recognized by only a minor subset of PB leprosy patient sera (12%, 11 of 89) and Brazilian EC individuals (6.7%, 2 of 30), but ML1556c reactivity was detected in a substantial number of Brazilian TB patients (35%, 9 of 26). These data indicate only a minor number of positive results in the Brazilian population if ML1556c is used for leprosy diagnosis, with a further complication of false-positive diagnosis in TB patients. Antigen ML0405, however, did not react with significant numbers of EC sera (3.3%, 1 of 30) or TB sera (12%, 3 of 26) (Fig. 4A). These results indicate that ML0405 can recognize some PB leprosy patients in the Brazilian population and could be used to augment leprosy diagnosis with PGL-1.
Construction of a fusion construct of ML0405-ML2331 (LID-1).Having extended our earlier observation that the single antigens ML0405 and ML2331 have the potential to diagnose leprosy (20), and given the observations that ML0405 appeared better for diagnosis in Goiânia and Cebu City but ML2331 appeared better for diagnosis in Salvador, we constructed a single fusion molecule incorporating both proteins. ML0405Tr was expressed at the C terminus of the molecule and ML2331 in the N terminus. Following recombinant expression, we validated the reactivity of the construct by assaying LID-1 versus a small panel of sera from Salvador that had bound each single component. These sera readily detected LID-1, ML0405FL, ML0405Tr, and ML2331 (Fig. 5A). Importantly, construction of the fusion protein did not introduce false-positive results with NEC sera (Fig. 5A).
We further extended our examination of sera from different geographic locations by assessing sera from Japanese leprosy patients for reactivity with ML0405, ML2331, and LID-1. Positive response were observed with MB patient sera (67% [20 of 30] for ML0405, 97% [29 of 30] for ML2331, and 87% [26 of 30] for LID-1) and PB patient sera (13% [4 of 30] for ML0405, 13% [4 of 30] for ML2331, and 20% [6 of 30] for LID-1), with few responses in EC sera (4% [1 of 26] for ML0405, 8% [2 of 26] for ML2331, and 4% [1 of 26] for LID-1) (Fig. 5B). Taken together, these data indicate that LID-1 is useful as a diagnostic antigen for leprosy.
LID-1 reactivity can diagnose leprosy before clinical symptoms.Having demonstrated that the LID-1 fusion molecule retained the ability to diagnose leprosy patients but lacked responses to EC sera, we obtained sera from a prospective study conducted in Cebu City, Philippines, between 1985 and 1991 (11). In that study, household contacts of leprosy patients were monitored over a prolonged period of time, and some developed clinical MB leprosy. In sera from the individuals who developed MB leprosy, as previously reported, anti-PGL-I levels increased before leprosy was diagnosed by clinical exam (Fig. 6A). Our data also indicate that anti-LID-1 antibody levels began to increase markedly as soon as 1 year prior to clinical diagnosis (Fig. 6A). For many of the patients (7 of 11, 64%) the increase in the anti-LID-1 IgG response was strikingly more obvious than the increase in the anti-PGL-I IgM response (Fig. 6B). Those patients that developed clinical leprosy had anti-PGL-1 antibody levels not dissimilar to many individuals who did not develop leprosy (Fig. 6C). The difference in anti-LID-1 antibody levels was much clearer, with a much larger differentiation between the positive responses of patients who developed leprosy compared with the extremely low levels of anti-LID-1 antibody in individuals who did not develop leprosy (Fig. 6C). Taken together, these data indicate that LID-1 is capable of providing an early serological diagnosis of leprosy.
LID-1 does not react with sera from individuals recently exposed to BCG.To examine in detail if leprosy diagnosis could be complicated by exposure to or infection with other mycobacteria, we also examined sera collected longitudinally from 10 U.S.-based individuals who were immunized with BCG. None of these BCG-immunized individuals developed positive serological responses against LID-1 or NDO-BSA (Fig. 6D). These data indicate that LID-1 can provide a clear diagnosis of M. leprae infection prior to the onset of signs that permit clinical leprosy diagnosis and that LID-1-based diagnostic tests could be used to expedite leprosy treatment.
Current diagnosis of leprosy is based on the appearance of clinical signs, and it is well established that the earlier a patient is identified the better their response to treatment. In addition, MB leprosy patient household contacts have a higher risk of developing clinical leprosy than contacts of PB leprosy patients (10, 12). This has been attributed to increased shedding and spreading of viable bacteria by MB leprosy patients (2). Accurate and early detection of M. leprae-infected individuals will open the possibility of earlier treatment that could both prevent disability and significantly reduce leprosy transmission.
We have evaluated the serological responses to a variety of M. leprae protein antigens in an attempt to discover antigens that can improve diagnosis of leprosy by detecting patients with a low BI (PB leprosy patients or early MB leprosy patients). We demonstrated that (i) ML0405 and ML2331 can be used to diagnose MB leprosy patients independently of geographic location; (ii) ML1556c can recognize some PB patients (although it is recognized by some TB sera as well); (iii) ML0405 and ML2331 can be used for diagnosis of some PB patients; (iv) a fusion construct of ML0405 and ML2331 (LID-1) retains diagnostic capability; and (v) LID-1 can provide a clear leprosy diagnosis before the onset of clinical symptoms. These findings will improve both leprosy diagnosis and patient care.
One approach for the early detection of M. leprae infection is through serological diagnosis. We have conducted screening to identify M. leprae antigens that have not previously been described, and we then evaluated the diagnostic potential of these antigens with leprosy patient sera. In this study, the diagnostic potential of select antigens was assessed in clinically disparate leprosy patient groups, ranging from MB patients who presented with large bacterial burdens and large skin lesions to PB patients who presented with low or absent bacterial burdens and a few, small skin lesions. As expected, MB leprosy patients were easier to identify by serological assays and typically yielded higher responses than PB patients. Unexpectedly, close examination of patients with a low BI from the Philippines indicated that some patients exhibited strong responses against the ML1556c protein. The responses of Filipino PB patients to ML1556c were often greater than those of MB patients. These results suggested the utility of this protein either as an adjunct to antigens that could identify MB patients to provide a cross-spectrum leprosy diagnosis or as a stand-alone protein for PB leprosy diagnosis. An objective and differential diagnosis of MB or PB leprosy could lead to better treatment of patients by guiding the multidrug therapy regimen provided to them.
We also analyzed the diagnostic potential of each antigen within geographically disparate groups of patients, from the Philippines and two sites in Brazil. In the Brazilian (Goiânia) PB leprosy patient group, ML1556c provided only a few positive responses; this dampened the enthusiasm for ML1556c to be a widely used diagnostic or prognostic leprosy antigen. Of interest, many PB leprosy patients in Brazil (both Goiânia and Salvador) could be diagnosed by ML0405 reactivity, and several PB patients (Salvador) could be diagnosed with ML2331 reactivity. It is unclear if the differences in the responses of patients from different geographic locations are related to differences in M. leprae strains or to regional variations in host genetics. These possibilities might be addressed by analysis of patient sera on fragments of ML1556c or by a survey of anti-ML1556c antibody on lysates of different M. leprae strains. Regardless, the observed differences indicate the importance of examining antigen-specific responses in several regions when considering their ability to diagnose leprosy globally.
Given that the ML0405Tr and ML2331 proteins could provide diagnosis of leprosy, we made a fusion protein (LID-1) of these individual components. After ensuring the fusion protein retained reactivity against leprosy sera from Salvador, Brazil, we tested the antigens against sera from Japan. As with results obtained using sera from Brazil, Japanese MB leprosy patient sera reacted as strongly with the fusion LID-1 as with the ML0405 and ML2331 components. In addition, some Japanese PB leprosy patient serum antibodies recognized these antigens.
Studies have argued that the presence of anti-PGL-I antibodies is an indicator of leprosy development, but this has been debated (5, 6, 14, 15). Many contacts of leprosy patients have anti-PGL-I antibodies but do not develop disease, limiting the capacity of PGL-I-based assays to predict disease development. Indeed, PGL-I-based tests are typically marketed as a support reagent to confirm clinical diagnosis and aid leprosy classification but are not recommended for use as a stand-alone for diagnosis (19). The differential in responses of sera from contacts that developed leprosy compared with contacts that did not develop leprosy was much greater for LID-1 than PGL-1. We demonstrated that LID-1 is capable of providing an early serological diagnosis of MB leprosy. A clear and early diagnosis was achieved in 7 of 11 contacts of leprosy patients who themselves went on to develop clinical leprosy. For the small panel of sera tested, the time benefit of a LID-1-based diagnosis over a clinical-based diagnosis was 6 to 8 months. Thus, screening for LID-1-reactive antibodies, either in the general population or within more focused at-risk populations, could significantly expedite treatment of leprosy patients and, also, affect transmission rates by reducing the number of individuals who develop large bacterial burdens. As another benefit, antibody levels against LID-1 dropped following the implementation of drug treatment in these individuals, and thus the reduction and disappearance of antibodies against LID-1 may be a useful measure of multidrug therapy efficacy.
We are currently evaluating additional antigens, diagnostic formats, and different geographic sources of patient sera with the objective of early and simple identification of leprosy patients regardless of incidence locality.
The manuscript is dedicated to John Dawson, without whom this work would not have been possible. We thank Randy Howard and Karen Cowgill for critical reading of the manuscript.
This work was supported by the American Leprosy Missions (S.R.) and the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (grant A20509) (M.M.A.S.).
- Received 18 July 2007.
- Returned for modification 16 August 2007.
- Accepted 28 August 2007.
- Copyright © 2007 American Society for Microbiology


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Who Are We?
The 9th grade band is made up of fourth and fifth year players. These students make up some of the top band students at Les Bois Jr. High. We will spend the year continuing to refine our ensemble etiquette, ensemble and individual technique, and expand our music vocabulary and range. We will also work to learn and memorize all major and minor scales this year.
Upcoming Events
Important Documents
Optional Events
February 13, 2020 - Band Rookie Night @ Timberline (optional)
March 4, 2020 - D111 Solo/Ensemble Festival @ BSU (optional)
March 7, 2020 - Jr. High Band Solo/Ensemble Festival @ Boise HS (optional)
Required Events
Jan. 28, 2020 - Timberline Quadrant Band Concert @ Timberline
Feb. 18, 2020 - Les Bois Area Band Concert @ Les Bois JH
March 13, 2020 - 9th Grade Band Late Nighter
April 9, 2020 - Pre-Festival Concert @ South JH
April 22, 2020 - Large Group Festival @ South JH (usually during the day)
Please refer to the Calendar for the full schedule of events.
Playing Tests
What and Why?
Playing Tests are designed to help the students grow individually. Each band at Les Bois will have a weekly playing test over scales, rhythms, or concert music. This material will be covered in class, but students are expected to put the practice time in at home so that the ensemble as a group can grow. Below you will find the rubric for the playing test.
Scheduled Playing Tests
Please refer to this Google Doc for playing tests for each class.
Here is a PDF of the Google Doc:
Concert Music Recordings
Guardians of the Galaxy
Arr. Michael Brown
The Best of Smash Mouth
Arr. Paul Murtha


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Two weeks ago we featured a few parentpenurs that are sharing their stories of life at work after having a baby. This week we want to continue to share some of those stories with you.
These new stories from the parentpreneur trenches highlight the diverse ways parents are creating their own ideal work situations for their goals and their families. They share advice on entrepreneurialism while balancing babies and children, marriages and key relationships, as well as tales of backing out of the traditional workforce to forge their own ways. We are delighted to add their stories to the first-person back-to-work parental experience mosaic that is the Portrait Project:
Click each picture to learn their story!
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Join us as we celebrate #ParentInnovators, through their PORTRAIT PROJECT stories now through Father's Day. And to top it all off, expect celebratory prizing! We will be giving goodies away to mark the moment!


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Why is my child so rude?
It's easy to get frustrated when your child is rude. You want to discipline them or even yell, but there's a reason that they're acting this way, so it's essential to be compassionate and try to understand what's going on with them. There could be many reasons why a child acts out, and it's necessary to sit down with them and work together to figure out what the problem is. So, how do you do this?
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What if they don't say anything?
It's okay if your child doesn't say anything. Allow them space to be there with you. It could take them minutes, hours, days, or weeks for them to open up, and how long it takes will depend on the child. The best thing that you can do in this scenario is usually to give them space. You can say, "maybe you don't want to talk about this right now, but I'm here if you need me."
Assure them that they can tell you anything and that you won't get upset with them. Sometimes, even kids that rarely receive punishment are afraid of upsetting others or making their parents mad. That is particularly true for shy or perfectionist children. Also, be mindful of the fact that kids might understand things differently and be willing to rephrase your questions or statements in a variety of ways until it resonates with them.
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You may believe that you think that you know what's going on with your child, but don't presume to know. Always ask and err on the side of caution. Although your child is, well, your child, and you do have a special connection with them, they are autonomous beings with their thoughts. Children are smart. They're conscious of the world and the people around them. What you assume are outbursts that are easily triggered or that come out of nowhere could be related to problems with anxiety, bullying, or fear about the state of the world around them.
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Children can also face genuine mental health conditions, which might be the culprit of their behaviour. Asking is always better than assuming, so even if you think that you know what's going on, be sure to double-check.
Talking about parenting in therapy
Therapy is an excellent place to discuss any parenting issues you may have. Don't be afraid to reach out for help if you don't know what to do. No parent is perfect, but you may find that talking about things in therapy, whether that's online or in-person, is helpful for you and makes you feel more secure as a parent.
Online therapy is an excellent option for busy parents and working professionals because you can access it anywhere with a stable internet connection. BetterHelp is an excellent option for remote therapy. It's affordable and offers support from licensed mental health professionals. Don't be afraid to ask for help. Parenting doesn't come with a how-to manual, and therapy might be the thing to take a lot of the stress that comes with it off of your shoulders.
This is a contributed post by Marie Miguel
Marie Miguel has been a writing and research expert for nearly a decade, covering a variety of health- related topics. Currently, she is contributing to the expansion and growth of a free online mental health resource with BetterHelp.com. With an interest and dedication to addressing stigmas associated with mental health, she continues to specifically target subjects related to anxiety and depression.


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Property Details
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Rare, 2 Bed, 2 Bath, 2 Balcony Condo with unobstructed views of Tanner Springs Park. Natural light pours into this southwest corner facing unit. Updates include white oak floors, lighting, and window treatments throughout. Sit back, relax, and watch the seasons change in the park and sunsets over the west hills. Steps from shops, restaurants, streetcar, parks, and all the Pearl has to offer. Gym, storage and deeded parking too! Fantastic value at an unbeatable price. View Virtual Tour!
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HOA Fees: $558/Monthly
Listing Courtesy of JMA Properties LLC
Contact: Marissa SainzBroker , Earth Advantage Broker
- The content relating to real estate for sale on this web site comes in part from the IDX program of the RMLS(TM). Real estate listings held by brokerage firms other than Living Room Realty are marked with the RMLS(TM) logo, and detailed information about these properties includes the names of the listing brokers. Listing data is copyright ©2020 RMLS(TM).
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Start the new year right with this ultimate guide on how to be the best trader you can be and achieve your goals in the market.
As 2019 comes to a close, I will say … it's been a year full of ups and downs for me.
A lot has been going on in my personal life; my emotional resilience was stress-tested on many occasions, but it's been a wonderful opportunity to renew my commitment to mindfulness, openness, wisdom, and compassion.
The world is an uncertain and risky place. I'm sure this is no surprise to you. Risk is everywhere and associated with almost everything.
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Pioneer Club is our ministry for girls in kindergarten through 12th grade. The motto of the group is "Christ in every aspect of life" and we do that through Bible study, singing,service, crafts, and cooking. We also enjoy several annual special events, including Father-Daughter Date Night, Family Roller Skating Night, and the Powder Puff Derby.
Pioneer Club is open to all girls and meets 7:00 to 8:30 during the school year. Girls may join at any point during the year — not just September.
There are six divisions of the club:
Scooters — Kindergarten
Voyagers — 1st and 2nd grade
Pathfinders — 3rd and 4th grade
Trailblazers — 5th and 6th grade
Challengers — 7th and 8th grade
Explorers — High School.
Questions? E-mail club coordinator Jill Norvilitis at


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June 2016 Letter from the Director's Office
Hello from High Street,
So that time of year, warm weather, outdoor activities, family, friends and visitors, it's called "Summer", is almost here. The Chamber Visitor Center is full of new guidebooks from around the state, updated brochures for everything from whale watching, to museums to wine trails. Visitors are slowly trickling in, wanting maps, directions and menus. We are ready, are you?
Perhaps the biggest marketing tool a city or town can have is its Chamber of Commerce. No, not our office building, the staff or the board, but you, its members. Every time you greet a customer, a diner, a reservation you are extending a welcome from the Ellsworth area. That person could be the next resident, business owner, developer, or know someone who is interested in coming to town. We all know great customer service when we get it. But are we giving it? Do you have employees who are knowledgeable about your business, as well as what else our area offers? Is your business neat and tidy, picked up from the winter's inevitable leftovers? You have one chance at that all important 'first impression'.
We are the ambassadors of what is the business community as well as the city and area at large.
Take some time this season to get to know your community so you can talk about our summer concerts on the waterfront, the quiet trails at Birdsacre and Woodlawn, the great food and dining experiences all over the area. You will be giving our visitors a real taste of hospitality, as well as the service your business is providing them. If we are not "high on Ellsworth" and the area who will be? The more we market our area, our surrounding businesses as well as ourselves the stronger case we make for why new business should come to our town.
Need some help with the inevitable summer questions? Come visit the Chamber office and we can guide you on what our area has to offer. Pick up your copy of Maine's Best Regional Guide. Even better, explore our community on your own. Get to know a trail, a museum, someplace you haven't been in our own backyard. Let's all spend the summer talking about all the things we DO have in this area, not the things we are missing. Happy Summer to you all!


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Job Description and Essential Functions
Job Title/Position: CMA/Prior Authorization Specialist
Job Classification: Administrative/Professional Support/Direct Patient Care/Hands-On Patient Care
Date of Analysis: Date of Revision/Review:
Prevea offers a competitive benefit package that includes Health, Dental, Disability, Life Insurance, H.S.A, 401k with match and PTO. Benefit summary sheets are available upon request or shown at www.prevea.com
Brief Description of Job Responsibilities:
Providing exceptional care for our patients as well as recognizing the value of your co-workers is the expectation of all members of the Prevea Health organization. All members are expected to focus on the patient`s needs; relate to all in a friendly, accepting manner; communicate in a positive and professional way to patients and co workers; use time effectively and efficiently; and demonstrate an overall high level of performance.
Specialized Responsibilities:
(This list may not include all of the duties assigned)
In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United State and to complete the required employment eligibility document form upon hire. Prevea participates in E-verify. To learn more about E-Verify, including your rights and responsibilities, please visit www.dhs.gov/E-Verify
Essential Functions/Physical Demands
Job Title/Position: Certified Medical Assistant/Prior Authorization Specialist
Job Classification: Direct Patient Care/Hands-On Patient Care/Administrative/Professional Support
How to Apply:
We have over 1200 reasons for you to consider a career with Prevea Health--they're our employees. We're an organization that values teamwork and provides continuous education, training and support so every member of the team contributes to our success. We offer a competitive salary and benefits package in an environment geared to professional and personal growth. No matter what your background or professional interests are, we think you'll like what we have to offer. Together we are the best place to get care and the best place to give care.
To Apply, please click on the button below and put 19-610 in the "What" box then select "Search For Jobs"
Prevea Health
Prevea Health is an Equal Employment Opportunity/Affirmative Action employer.


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Self catering holiday cottages to rent in Umberleigh, Devon, England
For the ultimate country escape, staying in a rural retreat, a barn conversion or country cottage in the charming, relaxing and scenic village of Umberleigh in North Devon could be perfect.
What Umberleigh offers for Cottage Breaks
The village of Umberleigh is a great base for exploring some of the best of Devon, especially since it's conveniently located just off the A377. The nearest big town, Barnstaple, is just 15 minutes away by car and there are plenty of other small villages and settlements close by waiting to be discovered and the coast is within a half hour drive too.
Umberleigh offers plenty of things for visitors to experience. There's an art gallery, where you can see works by all sorts of local artists, an antique shop home to all sorts of wonderful trinkets and centuries-old objects of value, an of course the village pub, which has a pleasant, inviting atmosphere and serves a range of delectable food. Over at North Nethercleave Farm you can see one of the only snail farms in the UK.
If you're a fan of scenic railway rides, you're in for a treat as Umberleigh is one of the stations on the Tarka Line, which stretches for nearly 40 miles between Barnstaple and Exeter. If country walks are your cup of tea, you'll be pleased to know that there are many in the surrounding area, offering intrepid explorers the chance to discover the raw and rugged beauty of the Devon countryside.
You can enjoy days out by the seaside too, not too far away when holidaying at Umberleigh. The lovely golden sandy beach at Westward Ho! is just 16 miles from Umberleigh.
Umberleigh is an ideal place to stay on your country cottage getaway as it's peaceful and quiet, with plenty to see and do, plus it's really well connected, so exploring the surrounding area is very easy too.
Book a Umberleigh cottage and look forward to discovering some of the best of Devon on holiday.


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tag:blogger.com,1999:blog-19517251.post4152043457316414240..comments2020-07-11T22:11:04.713-05:00Comments on Life 101 : Snow moonRick Watsonhttp://firstname.lastname@example.com:blogger.com,1999:blog-19517251.post-69683477145217199562019-02-19T20:30:10.145-06:002019-02-19T20:30:10.145-06:00A really nice photo, not as hot here todayA really nice photo, not as hot here todayJo-Anne's Ramblingshttps://firstname.lastname@example.com:blogger.com,1999:blog-19517251.post-33702516976905824232019-02-19T11:14:12.855-06:002019-02-19T11:14:12.855-06:00You had lots of newsy tidbits today. The picture o...You had lots of newsy tidbits today. The picture of the snow moon is gorgeous.Emma Springfieldhttps://firstname.lastname@example.com:blogger.com,1999:blog-19517251.post-60341787259220883862019-02-19T09:30:08.526-06:002019-02-19T09:30:08.526-06:00A great photo of the moon. It was so bright here t...A great photo of the moon. It was so bright here this morning when my husband went to the barn, he said it was like day light with the reflection on the white snow. We have another snow storm on the way and you have rain. I hope all this rain doesn't wash some of the roads away. Flooding is always damaging.
Stay safe.
Hugs, JuliaJuliahttps://firstname.lastname@example.com:blogger.com,1999:blog-19517251.post-67114302956308511192019-02-19T08:10:13.148-06:002019-02-19T08:10:13.148-06:00The picture came out 'Picture post card perfec...The picture came out 'Picture post card perfect' as I used to hear a lot. BUT every time I buy 3-4 gallons of gasoline for the mowers or generators, I sorta smile thinking, at one time I could fill a gas tank on the truck for that amount......
Nice day here in Florida (I hope you donot get 10 inches!)
Sherry & jackjack69https://firstname.lastname@example.com:blogger.com,1999:blog-19517251.post-64063301328293344882019-02-19T07:02:43.348-06:002019-02-19T07:02:43.348-06:00I actually took a shot at the moon last night too....I actually took a shot at the moon last night too. It had the glow ring around it with an overcast of clouds. Just beautiful. Your photo is amazing.
LisaLisahttps://firstname.lastname@example.com:blogger.com,1999:blog-19517251.post-37811039130142566412019-02-19T06:45:07.921-06:002019-02-19T06:45:07.921-06:00Not good ... it's great!Not good ... it's great!Mevely317https://firstname.lastname@example.com:blogger.com,1999:blog-19517251.post-3847915206047274462019-02-18T22:01:58.535-06:002019-02-18T22:01:58.535-06:00What a beautiful shot!! Amazing.What a beautiful shot!! Amazing.It's.a.crazy.worldhttps://email@example.com:blogger.com,1999:blog-19517251.post-48071030509693467592019-02-18T21:20:31.708-06:002019-02-18T21:20:31.708-06:00The photo is so good...an early spring look althou...The photo is so good...an early spring look although we got snow last night. I am looking forward to your writings from the people who lived through the war years. I bet you would have loved to have interviewed my mom when she was alive and still of sound mind especially since she even met Hitler like I mentioned before.Birgithttps://email@example.com:blogger.com,1999:blog-19517251.post-72807236142084146062019-02-18T20:26:49.765-06:002019-02-18T20:26:49.765-06:00You're right. The photo did turn out good. Alt...You're right. The photo did turn out good. Although, as you say, the camera you have with you is the best camera, its hard to beat a real camera.
Snow moon?
Alphie

 Alphie Souphttps://email@example.com


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CandW discuss the broadcast TV revival and OTT TV slump
TV broadcast network audiences have held steady since February even as they lost live sports. Could local news be responsible for the broadcast TV revival? OTT viewership is falling from its heights. Are services in need of a content injection?
Chapter 1: TV viewership holds up well during the C-19 crisis (1:30)
Alphonso says that the number of people watching ABC, NBC, CBS, Fox, and CW has remained unchanged from pre-emergency levels throughout the crisis. Maintaining the audience during these troubled times is an achievement for the broadcasters. They have lost live sports, and daily talk and late-night shows have either gone to re-runs or switched to social distancing formats. As well, some TV show seasons have run out of episodes.
Perhaps the broadcast TV revival as due to local news. Alphonso says local news broadcasts have maintained their audience throughout the crisis. Local news has been deemed an essential service and has maintained its schedule of regular shows.
Chapter 2: OTT viewers falling back from highs (8:00)
According to Alphonso, the March spike in OTT viewing is returning to pre-emergency viewing levels. The company says that the number of households streaming content peaked at almost 30% above January-February average levels. Since then, it has been in a deep decline. In early May, it was still 10% above average though on a downward curve.
Could the fall in viewers be due to the lack of new content? Many services like Disney+ and Hulu have been affected by the halt in production due to emergency restrictions. With much less content flowing into the services, viewers could well have run out of new things to watch.
Chapter 3: Netflix could be the exception (12:20)
There is one service that continues to release new shows at close to a pre-crisis pace: Netflix. In Q1, the company added 15.8 million new paying subscribers versus 9.6 million in Q1 2019. We have to wait for the company's Q2 results in July to find out if the original content provided a sustainable advantage.
Chapter 4: YouTube Preferred becomes Select (14:15)
YouTube has expanded the brand-safe content in its Preferred library dramatically and renamed the program YouTube Select. The social site is looking to boost viewing on connected TVs to attract more advertising revenue, and perhaps more TV ad spend. The new content will encompass genres such as entertainment, sport, technology, and beauty and fashion.


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This shard of ice was on Lake Superior by the Apostle Islands in Wisconsin. The sun's warm light had almost disappeared completely from the sky. When I saw this shard of ice in the snow reflecting the last of this warm light against the deep blues reflected from the coming night sky, I had to capture this. Please see this image as large as possible! (Click the image!)
I have to thank my experience in The Arcanum for processing this image. Everything from the fire to go and run up to Lake Superior for a day, to brave the elements, to see the sights, camera in hand, and then, as light was about to fade away completely, there is this shard asking for my attention. It was a little bit more of a scream. I tried to make ice look as sharp as I could. (Ice is never really sharp, you know that?)
When I brought it back into Adobe Lightroom I knew I had something worth sharing. But I also knew I wasn't done with it! It was explained to me that I needed to "purify the colors". I never knew what that meant. Then, one of my cohort members, Kyle VanEttan showed me how in a video critique. It wasn't just his critique that helped. There were others too.
I learned a lot. And when I get another chance to shoot such an interesting landscape, I'll know a little more to make even better captures. There will be better pictures in my future. More fuel for the processing fire. There will be more fuel to share with you. And the connections that I've made in The Arcanum will provide trusted resources to improve each other for years to come.
That is just the first 10 levels of learning with The Arcanum. I've learned a lot about my style when I didn't think I had any style. I've learned about where I want to take this. I've gained… a compass. The next 10 levels, I suspect I'll learn to chart my course.
Thanks for reading. If you're interested in The Arcanum, you know what to do.
Thanks again,


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Price: £3.99 for 40 tablets
Score (out of five): 4 1/2
Review: I'm comparing these to Finish Powerball Tabs which we used to use. I bought those from Lidl regularly as well, as they were often on a special offer that was just cheap, not a special offer.
My Lidl has a permanent few billboard spaces in the car park behind it, and I bought my first pack of W5 dishwasher tablets after these got a Good Housekeeping award and this was on a billboard. Being a sucker I thought I'd give them a whirl.
On their first outing I was a little bit disappointed. I'd put a greasy roasting tray in that I'd used for roast potatoes and everything came out with a slight sheen of grease on it. I was a bit worried that this would be one of the accidental Lidl buys - something that's actually a bit crap and you've got loads to get through. I think if I'd used Finish the grease would've been washed off, but that's probably because Finish contains chemicals I'd rather not use. I've now learnt to wash off any excess grease before I use these and they're now my standard dishwasher tablet and are excellent value for money. What's more, because they're gentler they're not running our cheap crystal glasses from TK-Maxx like Finish was.
In this Guardian article where a woman "downsizes" from Ocado to Lidl she is very disappointed with the dishwasher tablets. I can only think she went for the absolute cheapest, not these. I would definitely recommend these.
Tuesday, 25 November 2014
W5 All In 1 Dishwasher Tablets
3 comments:
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FIBEGA Miami 2019 has the honor of announcing Macao as Finalist for the FIBEGA Gastronomy Tourism Awards in the Emerging Destination category.
Macao is a region of China nestled about an hour's ferry ride from Hong Kong. This small, stunning region is a manifestation of a unique blend of Portuguese and Chinese cultures which has resulted in cuisine that is deliciously distinct. In 2017, Macao was designated as a UNESCO Creative City of Gastronomy, in part due to it's 19 Michelin-starred restaurants, 12 Michelin recommended street foods and a wide-variety of hidden gems. A few of the must-try local dishes include: African Chicken, Macanese Egg Tarts, Pork Chop Buns, Serradura, Macanese Almond Cookies, and more. Whether on the hunt for Portuguese, Chinese or the unique blend known as Macanese, food lovers will find a haven in Macao.
There are a lot of things to do in Macao:
Discover the Historic Centre of Macao: Composed of over 20 monuments, the stunning architecture and cultural significance of this UNESCO World Heritage site is not to be missed. Must-see attractions include the remarkable Ruins of St. Paul's, the Mediterranean atmosphere and pastel buildings of Senado Square, the European-style of Dom Pedro Theatre (the first of its kind in China), and St. Dominic's Church, one of the most beautiful churches in Macao.
Enjoy Gourmet, Michelin-Starred Food: With 19 Michelin-starred restaurants and many more Michelin-recognized food trucks, Macao is a great place to come hungry and truly delight in delicious meals and snacks at every turn. A few "worth the splurge" Michelin restaurants are: The Eight, Mizumi, The Tasting Room and The Golden Peacock. If you're hoping for something more casual, try a view of the local hot spots such as: La Famiglia Restaurant, Sei Kee Café, Restaurante Local, Lord Stow's Bakery, and Henri's Galley.
Create Your Own Macanese Cuisine: If enjoying the tastes isn't enough, truly be immersed in the culture by taking part in a Macanese cooking class. You can learn to make your very own exotic and delicious dishes of Macao, such as African Chicken, Portuguese Egg Tarts, Minchi and more.
Enjoy a Walking Tour of Macao: Take in Macao's beautiful history and culture via one of the do-it-yourself walking tours. Pick up a walking tour pamphlet at a local tour shop and stroll along stunning Macao on your time, choosing the path that best suits your interests. Whether you're a history buff, foodie, or adventurer, there's a tour for you.
Adrenaline Rush at Macau Tower: Every cosmopolitan metropolis has an iconic giant at the core of its skyline, and the Macau Tower does not disappoint. Over 1000 feet tall, the observation deck at the top is full of thrills. Skywalk X is a staggering guided tour along the outer rim of the tower. And for true daredevils, one of the world's tallest bungee-jumps can be arranged from this height. For a more mellow experience, a restaurant also awaits with panoramic views.
These are some of the many reasons to discover Macao, but there are many more that can be seen in this video:
Source: MacaoTourism