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A remote controlled drug delivery capsule for use in absorption studies has been developed by a UK company. The new technology, called the Enterion capsule. The Enterion capsule has been developed to investigate the absorption of The technology has been in routine use for several years and. formulations and delivery technologies that target the right place in the GI tract. delivered to specific sites via the Enterion capsule. The drugs.
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For example, if the applied preload force is 1. The future of wireless capsule endoscopy.
Nowadays, capsule platforms are also available for the non-invasive exploration of the oesophagus and the colon[ 1011 ]. A Capsule Camera to Save Stomachs. About Quotient Bioresearch Quotient Bioresearch is a leading provider of early stage and specialist drug development services to life science clients worldwide.
Wash-burn for synthesizing the mucoadhesive polymers and the members of the NanoRobotics Etnerion for their continuous feedback and suggestions. A major task of the project was to develop nanocontainers, labeled with targeting agents and filled with dyeing material. The Enterion capsule was developed by Phaeton Research, Nottingham, United Kingdom in association with the Nottingham University spin-off Pharmaceutical Profiles for targeted delivery of a wide range of different drug formulations into any region of the gut[ 3738 ].
December 24, Peer-review started: Potential screening benefit of a xapsule imaging capsule that does not require bowel preparation. Issues to be addressed before such a capsule is applicable in clinical practice, include the use of biocompatible polymer materials for enhanced friction technoogy the slippery environment of the GI tract, energy conservation, e.
Br J Clin Pharmacol.
Magnetically Actuated Soft Capsule With the Multimodal Drug Release Function
B max was maintained at 0. Design and Characterization Fig. Recently, the feasibility of a novel method of controlled colonic insufflation via an untethered capsule in vivo was demonstrated Figure 4 [ 36 ]. In conclusion, we should relish the challenges that lie ahead; in an cspsule like the small-bowel, the requirement is not to cxpsule micro-capsules; instead the attention should focus on how to utilize the existing carrier shape and size, but with miniaturized components such as microscopic batteries, that will leave internal space and provide enough power for internal lens rotation just like the deep sea submarinesspace for microscopic labs lab-in-a-pill and other sensing capacities and -hopefully- deliver powder medication for bleeding.
See other articles in PMC that cite the published article. MASCE with two internal magnets. Introduction Current medical technologies are developing toward minimally invasive diagnosis and therapy. Another task was to develop a capsule based on narrow tecbnology imaging, combining specific optical filters with light emitting diodes LEDs.
It supplies practical advice on the issues facing prescribers in all types of practice. December 31, First decision: Following ingestion, the capsule is carried down the oesophagus by natural peristalsis. In the part A and B, the drug release is almost continuous. One possible solution for the first issue is to assemble the drug chamber with the main capsule in the stomach after inserting separately. Shape-programmable soft capsule robots for semi-implantable drug delivery.
Such a modular robot can be used for thorough inspection of regions of the GI tract.
Magnetically Actuated Soft Capsule With the Multimodal Drug Release Function
For more information please take a look at our terms and conditions. Nat Rev Gastroenterol Hepatol. At A, the chamber is abruptly xapsule by the external force, which is the critical force F cr: Main limitation of this capsule was the difficulty to include a power source, because most of the space within the capsule was covered by the electro-mechanic components used for moving the robotic legs.
Parallelly, Professor Paul Swain, a British gastroenterologist, led a research group in London and published the first conceptual studies on a wireless capsule in [ 67 ]. Differing from the first mode, in the polymeric drug-coating mode, even a highly viscous drug can be released because the abrupt compression of the drug chamber gives a strong fluidic force to the squeezed drug.
Another prototype included a submersible capsule prototype equipped with four propellers for locomotion. Yu J L- Editor: Inchworm-like microrobot for capsule endoscope. Expert Rev Med Devices. The proposed chamber design has two improvements as compared with [ 12 ].
Formulation tech goes Enterion
In a recent experimental study with live canine models, 4 mongrel dogs underwent laparotomy and the implantation of suture markers to approximate colon lesions. However, no human studies have been conducted with this capsule, which has been described on the web for almost a decade now[ 12 ]. Furthermore, the magnetic actuation enables the soft capsule endoscope to roll on the surface of the stomach.
The SUPCAM project[ 55 ] was funded by EU FP7 during for the development of a spherical endoscopic capsule which can be safely – and accurately – guided along the colonic lumen from the outside, through an electromagnet, in completely wireless mode[ 56 ]. Perspective article Review article Research article. The cytoplasm of the cell swells as soon as exposed to HCl because the cytoplasm which had been dried on the glass substrate, absorbs the water of HCl solution.
For example in the developed prototype the axial magnetic attraction compresses a drug chamber between two internal magnets so as to release a drug through holes at a critical pressure.
Perhaps adrenaline injection directly into a bleeding small bowel angioectasia is not a bream after all. The use of the intelSite companion device to deliver mucoadhesive polymer to the dog colon. Clinical Pharmacokinetics A practical guide to the use of pharmacokinetic principles in clinical practice.


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Kiton announces new store opening in Marbella-Puerto Banús
3 May 2019 – Kiton strengthens its presence on the Spanish market with a new store opening in Marbella, in the heart of the city's luxury shopping district, Puerto Banús.
Covering an area of 110 square meters on a single level, the boutique will showcase the Men's, Women's and Accessories collections, as well as the KNT urbanwear line. An in-store area will be dedicated to our Bespoke service.
Kiton has been present in Spain since 1990, through its network of multi-brand distributors in the country's most sought-after luxury shopping destinations, as well as its flagship store in Barcelona. The new store opening in Marbella celebrates the brand's great success in the Spanish market.
«We are very proud of our growth and expansion, and the opening of a new store in such an exclusive location as Marbella is another step forward in our development, in line with our customer-oriented philosophy», said Kiton CEO Antonio De Matteis.
Calle Muella Ribera, 5
29660 Puerto Banús
Marbella, Spain

subset: commoncrawl


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What could be better on a warm and sunny Sunday morning in July than a trip into the hills around Barga to Pegnana. This area is often used during the autumn and winter .. after all, the Befana's house is at Pegnana but it is also the perfect place to sit under the cool chestnut tress in the summer months. Luckily the comitato paesano in the area have been organising the annual sagra and this afternoon visitors to the Piano di Pegnana were greeted by the unmistakable aroma of meat cooking over a wood fire and something much sweeter being cooked in the background which turned out to be necci. Thunderstorms circling round the mountains managed to be kept at bay for one of those special Sunday lunches under the huge chestnut trees and then finally down came the rain and it was time once to flee back down the mountain side to Barga
Necci – the simplest of ingredients …. sweet chestnut flour, water and salt mixed into a thick paste and cooked between two hot plates over a flame. Two metal plates, the testi or cotte, are oiled and heated and the chestnut paste is poured onto one of the plates, the other is placed over the top so that the necci can be cooked from both sides. A stick to press down on the top plate and in seconds you have one of the tastiest foods in this area. Add some ricotta and you have quite simply the Food of Gods.
Roasting chestnuts in Pegnana during the autumn can be seen here


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Learn how to get started with Microsoft's new Project for the web in just a few minutes.
Thanks Antti… do you have a walkthrough of exactly how PSA and the new Project integration works? I've been working on deploying PSA and have found the lines between Project, and PSA are very blury now, with the renaming, transition to CDS, apparently delayed release schedules not keeping up with projected release dates, PSA documentation being a WIP, PSA Release notes on a separate blog managed by the product manager, etc. As an SME, I figure you probably understand it better than most. Any summary you can provide would be much appreciated.
You must be logged in to post a comment.


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The Supreme Court on Friday ordered that no FIR can be registered against actor Priya Prakash Varrier for a wink scene in a song in Malayalam movie 'Oru Adaar Love' for an offence of hurting religious sentiments of the Muslim community.
A bench of Chief Justice Dipak Misra and Justices A M Khanwilkar and D Y Chandrachud noted the folk song, shot with Varrier, has been in public domain since 1978 and it cannot be termed as blasphemous.
"The picturisation of the said song solely because of the 'wink' would not tantamount to an insult or attempt to insult the religion or the religious beliefs of a class of citizens. The said song has been on Youtube since February 2018," the bench said.
The court quashed an FIR lodged by Telangana police on February 14 against the 18-year-old actor from Thrissur and producer and director of the movie under Section 295A of the IPC, finding no "calculated tendency" by the petitioners to insult or to disturb public order.
The song 'Manikya Malaraya Poovi' has become a rage as it was seen by lakhs of people.
During the hearing, a counsel, appearing for the person who filed a complaint, contended he has no problem with regard to the song as it is a folk song but his grievance related to the very manner of picturisation.
"The informant in all possibility has been an enthusiast to gain a mileage from the FIR, though the same was really not warranted. What is urged before us is that picturisation which involves the actress with a wink is blasphemous. Barring that there is no other allegation. Such an allegation, even if it is true, would not come within the ambit and sweep of Section 295A IPC," the bench said.
The court allowed the petition filed by Varrier and others and directed no FIR or private complaint should be entertained against the petitioners on the basis of the picturisation of the song.
The court also relied upon previous orders passed in the case of movie 'Padmavat' and cricketer M S Dhoni and a judgement by Constitution bench in 'Ramji Lal Modi' to conclude Section 295A cannot be attracted here.


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About Valkyrie
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TA22 Celica
nisskid's 32 4 door
Valkyrie replied to nisskid's topic in Members Rides^But that's a Toyota, not a Nissan pos
The SR that could (when it was there...) Now 501rwkw of 2JZ power!
Valkyrie replied to tas_180's topic in Members RidesWere you on new tyres when you ran against Michael? Your car was so much faster in the battle against Michell, but slower during the re-run. It may be worth testing your tyres further as the speed loss was noticed by everyone on the hill. Your car stops so much faster than any other car. It could be visibly seen with how late you could handbrake into turn two. I forgot to say, welcome to the wonder that is the Toyota inline 6
Gossy's 400kw RB30 S13 build...tassie style!
Valkyrie replied to madskidz's topic in Members RidesAre you going to be driving your white anti-powerskid drifter at all this year? Your Tasmanian, sorrounded by the best beer in the world and look at what you drink So the S15 is going on the back burner or are you going to be a one man three car team? I'm pleased to see Brendo's old bus being revived Justin
Wayne had a good old laugh when I told him you were still using the last of your tyres from 2009.
ADGP Round3 Feedback
Valkyrie replied to GODZILLA's topic in MotorsportsThe constant Facebook updates were fantastic!
Mandi's 180sx - Parkway drive appreciation thread
Valkyrie replied to Mandi's topic in Members RidesTwin dumps are good for these due to the heat issues the standard ones use. Even if dumps are the only mod, they are good for the longevity of the factory turbos I'm glad to see your now rolling with a real engine as well
I hear it looks tough with those baller 15x8 SSR's
Mandi's 180sx - Parkway drive appreciation thread
Valkyrie replied to Mandi's topic in Members RidesHey Mandi, get some dumps fitted while the car is apart. Ash made 211rwkw in his 180SX with dumps, 3"straight thru exhaust, fuel cut defender and 15psi. Ash also swapped my standard dumps for a big twin dump setup that Joash made. He had them off and on twice due to a gasket leaking If you want info on who makes them, just ask or PM me.
That turbo is going to destroy a standard clutch in no time if you have any grip. Have you purchased a decent clutch (NPC or Jim Berry)?
Your last run was scary to watch. I didn't realise how stuffed your clutch was Your car was putting out rooster tails so it has a ton of grip and power Any one want to buy Ash a Jim Berry or NPC clutch ?
E85 available at Sandy Bay United servo
Valkyrie replied to Valkyrie's topic in Australia - TasmaniaNo, they have both E85 and E10. E85 is out of the pump against the wall.
E85 available at Sandy Bay United servo
Valkyrie posted a topic in Australia - TasmaniaThey are selling it for $1.35/litre as of 5/4/12. I don't know about its quality, so buyer beware etc etc.
4th gear between one and two biatch
Anyone remember Drift Battle magazine?
Valkyrie replied to ToySprinta86's topic in MotorsportsVenturing to Claremont
The dumps can be modded, but they point straight at the steering shaft... They'd be good for the flange and a small part of the piping. I have no doubt you'd be able to mod them to fit though.


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(139) stories found containing 'white rock minerals'
Sorted by date Results 1 - 25 of 139
Mineral riches lure explorers to Yukon
Though mineral exploration in Yukon Territory this year lagged the pace seen in 2018, mine development projects advanced at a steady clip in 2019, while several past-producing mines moved... — Updated 7/10/2020 Full story
Alaska is a great place to do business
When it comes to mineral exploration incentives, currency exchange and infrastructure, Alaska is at a disadvantage in the realm of attracting exploration investments from Canada and... — Updated 7/10/2020 Full story
Tectonic stakes new Goodpaster gold claims
Tectonic Metals Inc. July 25 announced that it has added a new gold property in the Goodpaster Mining District and acquired a dataset that will assist the company's exploration across... — Updated 6/26/2020 Full story
Alaska is rich in critical rare earths
Alaska is rich in rare earth, a unique group of elements that are so distinctive that most are placed in their own separate section at the bottom of the periodic table. While scientist... — Updated 6/22/2020 Full story
White Rock, Sandfire team up in Alaska
With a major investment by fellow Australian company, Sandfire Resources NL, White Rock Minerals Ltd. focused its 2019 exploration on discovering the next high-grade zinc and precious... — Updated 6/22/2020
PGEs – the hard-working precious metals
The six platinum group elements – platinum, palladium, rhodium, ruthenium, iridium, and osmium – are amongst the rarest metals on Earth. This scarcity, coupled with PGEs' uses in the... — Updated 6/22/2020 Full story
White Rock explores for Last Chance gold
White Rock Minerals Ltd. June 10 said a team of geologists is slated to explore the Last Chance prospect in preparation for the first drilling at this gold discovery on the company's Red... — Updated 6/19/2020
White Rock expects 2020 Alaska program
White Rock Minerals Ltd. April 5 said that despite the market uncertainty and travel restrictions related to COVID-19, it intends to carry out at least a limited drill program to expand... — Updated 4/17/2020
White Rock adds Tintina Gold Belt target
White Rock Minerals Ltd. Jan.28 announced the discovery of a large gold anomaly at Red Mountain, an expansive Alaska mineral exploration project better known for the zinc-rich volcanogeni... — Updated 2/21/2020 Full story
Alaska mining to get Aussie boost in 2020
With two Australian companies making major investments and several exploration companies from Down Under chomping at the bit to get into the field, 2020 is shaping up to be the best year... — Updated 1/17/2020 Full story
Doyon's vast Tintina Gold Belt potential
With 12.5 million acres of land spanning Alaska's Interior, Doyon Ltd. is the largest private landholder in the state and one of the largest in the nation. For mining and mineral... — Updated 12/30/2019 Full story
Old mining risks yield to new concerns
As the year winds down, mineral industry evaluations for 2019 are being published at a rapid rate. One of the most interesting such global reviews is EY Global Mining and Metals' annual... — Updated 12/20/2019 Full story
High-grade zinc shows Dry Creek potential
White Rock Minerals Ltd. Nov. 4 reported that it has tapped high-grade zinc mineralization that indicates a major expansion of the Dry Creek deposit at its Red Mountain volcanogenic... — Updated 11/8/2019
Drill discovers major Dry Creek extension
White Rock Minerals Ltd. Oct. 29 said the last hole of its 2019 drill program at Red Mountain indicates the potential for significant resource expansion at this zinc-rich volcanogenic... — Updated 10/31/2019 Full story
New zinc target tops Red Mountain list
White Rock Minerals Ltd. Sept. 19 said it has identified another prospect to add to a growing list of drill targets at Red Mountain, a high-grade zinc and precious metals volcanogenic... — Updated 9/27/2019
Sandfire ups 2019 spend at Red Mountain
White Rock Minerals Ltd. July 16 announced that its joint venture partner Sandfire Resources NL has committed another US$1.5 million into the 2019 exploration at Red Mountain, extending... — Updated 9/26/2019
Seeking the next big Red Mountain deposit
White Rock Minerals Ltd. June 24 provided an update on the 2019 exploration program it is carrying out with joint venture partner Sandfire Resources NL to discover the next high-grade zin... — Updated 9/26/2019 Full story
Alaska mining traces erratic global trend
If you have watched the metals markets over the last month, you know why Alaska's mineral industry has surged, stalled, swerved, swooped, slowed, shelved and stuttered, sometimes all at... — Updated 9/26/2019 Full story
Alaska's topsy-turvy exploration season
As the rest of the country suffers through the Dog Days of summer, Alaska is approaching the end of a topsy-turvy summer season that saw unseasonably hot, dry weather in some parts of the... — Updated 9/6/2019 Full story
Freeman throws down rare earth gauntlet
Earlier this month Reuters reported that several agencies within the U.S. Federal government were "rapidly assessing" our domestic ability to mine and refine rare earth elements and... — Updated 7/26/2019 Full story
Metals feel love, explorers not so much
Earlier this month S&P Global put out a summary indicating that during the first quarter of 2019 metals like copper, zinc and nickel were up quarter over quarter by 11 percent, 22... — Updated 7/19/2019 Full story
Red Mountain 2019 drilling set to begin
White Rock Minerals Ltd. May 20 announced the completion and preliminary results from a 311-mile (500 kilometers) airborne electromagnetic survey flown over its zinc-rich Red Mountain... — Updated 5/31/2019
The 2019 mining game is afoot in Alaska
In the famous words of Sherlock Holmes, the game is afoot! After seasonally slower news from Alaska's mining industry in March and April, the dam has broken with over two dozen Alaska... — Updated 5/30/2019 Full story
Calm before the 2019 exploration storm
As is usually the case this time of year, news about Alaska mineral activities is a bit sparse this month as planning activities are at flank speed ahead of next month's surge in field... — Updated 4/26/2019 Full story
Aussie explorers ready for Alaska summer
White Rock Minerals Ltd. April 9 reported that following the March 25 signing of a joint venture with Sandfire Resources, the two Australian companies are already gearing up for an... — Updated 4/19/2019