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Discover meaning in travel
I love traveling. I have been to a plethora of countries spanning 6 continents and 100+ cities of the world. Being a world traveler, I realize, however, that what I enjoy most isn't just the beautiful landscapes or delicious cuisines, but my interactions with local people; those experiences were like stamps, carved in my mind and served as a permanent reminder of optimism, aspiration, and motivation in my life. I still vividly remember when I visited a rural area in Yunnan China, where a 7-year-old boy worked full-time in doing chores meant for adults, in order to ease the family burden. My heart squeezed. Wanting to help out, I offered him some food and books so he can temporarily supplement nutrition to the body and brain. At the end, when I was about to leave, he said: "I had a good time, can you please stay with me?" It touched my heart. I extended my stay for another hour or so. Before my departure, he hugged me tight and told me to come back again. I left devastated, wishing that I could stay with him or had a more sustainable way to feed him and release him from the shackles of physical labor. I know there are many more people like him out there. In another time, I met these sisters in a small village in Shaanxi China. It was late summer, where the weather was scorching hot and full of mosquitoes. The little sister's whole body was bitten by the mosquitoes and I felt so bad. I asked her if it was very itchy, and she said yes but that she was accustomed to it since she has to deal with it every day of the summer. I gave her two bottles of mosquito spray and showed her how to use it. After I left her, my heart ached -- their parents make a living by recycling the trash, their house is a few meters away from a giant dumpster, and the kids are raised with a bad-smelling environment with flies and mosquitoes everywhere. But even so, they are happy and optimistic. I am grateful for everything that I have today, but knowing that there are many others who lack basic life essentials and have unfortunate lifestyles, I am motivated to make a difference in the world and change people's lives.
Hi Harvard!
I was excited when one day, I turned on my computer and found out that I received an email from Harvard, congratulating me for my admission to the Business Analytics Program! I am delighted to share my experience with the community and to the thousands of people out there from all over the world who also want to apply for the same program. I hope my personal statement can provide some useful tips on what constitutes a solid personal statement and topics that would be nice to cover. Please see below – hope it helps! ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- On a Sunday afternoon, I was browsing my newsfeed on LinkedIn, when I saw a post about the Harvard Business Analytics Program. This set off a memory of when I was only 10 years old with a Harvard student who tutored me math and English. That experience was so unforgettable and has positively impacted my life. With that excitement, I looked into the curriculum of the program and saw it is designed to strengthen core management skills and ability to find innovative ways to analyze, predict and apply data strategies across business sectors. As manager of customer analytics in a global fast-paced technology company, I find the deep necessity to enhance data-driven techniques, get exposure to digital strategy and innovation and sharpen my management skills. There is no better program and community than the Harvard Business Analytics Program to provide the skills and experience I need to excel at my current position, while preparing for my ultimate goal of building and leading a world-class analytics team at Dropbox. With a heavier background in business over technology, I sometimes find it hard applying right techniques in solving a business problem. Often it is due to unawareness of the existence of a technology and limited knowledge applying it. Also, it results in the lack of innovation and inability to optimize resources. Last week we were discussing how to turn unstructured survey data to structured data, ultimately to insights. We currently rely on a third-party vendor, but it's not the ideal solution as it is very expensive and we have no way to validate their results due to lack of skillset and bandwidth. Realizing that if I want to change the situation or eventually bring the exercise back in house, I must develop some data science techniques to at least recognize the technology behind an exercise and the complexity of it. With my team growing I also need to enhance leadership skills. Becoming aware of the Leadership and Innovation class where the instructor employs the congruence model linking strategy to execution through alignment of culture, people, tasks, and executive leadership, I know this program will help me. To be a better manager, I am still trying to find the optimal balance between getting the job done and building relationships, I hope to find an answer through the class. There are numerous other examples to support the conclusion that I need to better data technology and management skills to maximize efficiencies and outcomes for my company. As an individual, I am passionate, culturally aware, and supportive. I bring positive energy to people as well as excite and motivate them to dream bigger. I have many topics to contribute – from having lived in four countries in the past ten years, to building a worldwide community (to learn more please visit www.sangclub.com). As a business professional I am extremely motivated, persistent, and willing to learn. If I had the honor to be admitted to the program, I would love to share my career stories, build meaningful connections, contribute my knowledge in business analytics, get involved in communities offering help, and discuss trending techniques around data and leadership. Thank you very much for your consideration! ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Chichen Itza, not Chicken Pizza
If you were ever looking for a fantastic weekend getaway, I highly recommend visiting Chichen Itza, another of the Seven Wonders of the World. My work schedule is extremely busy but nevertheless I was able to make this trip happen without missing a day at work! I will give you a quick overview of how I made it in three days. I departed SFO on a late Friday night, arriving at CUN on Saturday at about 7 a.m local time. The weather was stunningly beautiful and warm, a stark contrast to windy and chilly San Francisco. Chichen Itza is a two hour drive from Cancun, so I recommend picking up a car near the Cancun airport, as it is the most convenient and inexpensive option. Make sure to book it advance, which costs only $5/day. On the way there, you will be required to pay tolls in cash(pesos), the local currency, because other currencies and credit card are not accepted. I grabbed a hearty breakfast at a nearby hotel, called Bel Air Collection Resort & Spa, which had an amazing view of the ocean at the beach onsite. After breakfast, I began driving to Mayaland Resort & Bungalows, the hotel that I would stay for the night. The drive is very simple and involves driving on a straight road for the majority of the time. Mayaland Resort provides not only free parking but also its own entrance to Chichen Itza to avoid the long lines. There is also a buffet here for those that want to grab something to eat. The next destination was visiting Cenote Ik Kil, a short drive from the hotel, and one of the most breathtaking places I have ever experienced in my entire life. Feel free to bring swimsuits and spend time swimming in this gorgeous cenote. After admiring the beauty of nature that the cenote has to offer, I headed back to the hotel to watch a night time show. It was a unique 360 immersive experience that you watched on the ceiling of the room. It provided a historical perspective of Chichen Itza and various mythological stories that revolved around this landmark. I got up in the morning at 7 a.m. the next day to eat breakfast and prepared to visit Chichen Itza, which opens from 8 a.m. to 4 p.m. Chichen Itza itself is a city built by the Mayans and was critical from about 600 AD to 1200 AD. When entering Chichen Itza, I first encountered what was known as the Group of a Thousand Columns. Divided into three separate regions and with a roof previously on top, these columns served both civic and religious purposes. The main attraction to see at Chichen Itza is the pyramid El Castillo, also known as Temple of Kukulcan. A fun fact about this pyramid is that each of the four sides consists of 91 steps, meaning that these steps, along with the temple platform on top, results in 365 steps! Other places of interest worth visiting in Chichen Itza are the Great Ball Court, Sacred Cenote, the Osario, and El Caracol (observatory). Note that the cenote here is only for viewing purposes and not for swimming. Overall, about 3 hours was spent visiting Chichen Itza. While at Chichen Itza, I left my luggage in the hotel room and returned by noon for check out. I then drove to Playa del Carmen to take the ferry to the charming island of Cozumel. At Playa del Carmen, I had one of the most delicious meals at a must-try restaurant called Carnitas y Barbacoa Silao. Unfortunately, most of the beaches were closed on Sunday, but it was still wonderful to breathe the air of Cozumel. After taking the ferry back, I ended my day by staying at Courtyard by Marriott Cancun Airport, a nice hotel that provides a free shuttle service to and from the airport. My flight was 6:45 a.m. the next day, so I was able to arrive in San Francisco and continue with the rest of my day. Although my trip was relatively short, it was a fulfilling and productive weekend spending it in Mexico and completing another of the Seven Wonders of the World!


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Bright smiles and eager faces of our new set of students said it all! The AISFM Inaugural Session of 2017 welcoming the students and their families into the AISFM fold, was celebrated at N Convention Hall. The session started off with a flourish with a montage of all the nine Grad Films of our … [Read more...]
AISFM Inaugural Session 2017, A Great Start!
August 9, 2017 By Team AISFM
Filed Under: Acting and Performing Arts, Admissions, Advertising and Digital Marketing, AISFM News, Alumni, Animation and VFX, Courses, Entertainment, Events, Faculty, Featured, Film and Television, Graphic and Multimedia Design, Guest Faculty, Journalism and PR, MBA and Media Management, Photography and Digital Imaging, Students, Techniques, Technology Tagged With: AISFM, amala akkineni, education, film school, future, great start, inaugural session, krish, new batch, new year, radha krishna jagarlamudi, students


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This week, the Chicago Tribune reported that the CTA plans to renovate the Illinois Medical District blue line stop that serves four of the city's major hospitals just west of the South Loop and University Village. The CTA stop serves over a million visitors each year but has not had a major renovation since it was built in 1958, according to the article. It goes on to say, "The project includes upgrading station-to-platform ramps at Damen Avenue and Paulina Street, and the Paulina entrance will get a wheelchair-accessible gate." Other elements the CTA has planed include will include improved station and platform lighting, installation of new security cameras, new bus and train tracker displays, and improvements to the station canopy. This is all in addition to a significant facelift of the Ogden station. The project is expected to be completed in 2017 and will be funded with TIF money.
The Illinois Medical District is located between Ashland and Western and between Lake St and 15th Street. It is home to Rush Hospital, Stroger Hospital, the Jesse Brown VA, the University of Illinois Hospital & Health Sciences System and Malcolm X College. It also home to the now-abandoned Cook County Hospital, which is a stunning Beaux Arts gem that preservationists have been trying to save. It appears they may have succeeded, with the Cook County Board approving a development plan in April that would convert the building into apartments, shops and a hotel.
*Photo courtesy of Flickr user John Greenfield.
File: Illinois Medical District blue line


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Nitro Squash Splitboard | 2021
With the success of the Squash in the Quiver line, Nitro have added a split version, the Squash Splitboard. It combines the versatile carve/pow shape of the Squash with the splitboard concept. Pow days & sunny groomer days – the Squash board specializes in both areas by prioritizing float through the deepest of pow and offering a progressive sidecut you can lay into lay into like you do it for a living. Designed to rip pow and engineered to get you there. The 2021 model includes custom skins
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GLASS: Bi-Lite Laminates – Nitro's rider-trusted Bi-Lite Laminates are engineered for a powerful riding style and a refined board-feel.
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Orders placed before 1pm are processed and booked for shipping the same day. Large packages like snowboards must ship via a courier to a fixed address.
"The Squash Splitboard combines the versatile powder/carve shape, and puts it into a splitboard version"
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Search Events
Big Muddy Blues Festival 2019
Every Labor Day weekend, St. Louis' historic Laclede's Landing hosts over 30,000 people from around the country for the Big Muddy Blues Festival. This very popular outdoor music festival attracts an eclectic audience celebrating the rich St Louis history of "the Blues."
The Big Muddy Blues Festival provides a platform for our world-class musicians representing a wide range of blues music including, Delta, Country, R & B, Soul, Rock, and more. Big Muddy is the region's largest Blues music event featuring a 100% local line up of over 50 bands and musicians. The festival takes place along the cobblestone streets of Laclede's Landing, while boasting the Big Muddy (Mississippi River) itself along with the Gateway Arch as the backdrops for the weekend. Music will be showcased on 3 stages, 3 indoor clubs, and two events at the National Blues Museum featuring tributes to Albert King and Tommy Bankhead.
Big Muddy Blues Festival is one of the longest-running events of its kind and is produced annually by Laclede's Landing Merchants Association. Formed in 1979, LLMA is the nonprofit group of Laclede's Landing restaurants, bars and shops that focuses on preserving and revitalizing St. Louis' oldest community and introducing people to the historic area through its various businesses, events and sights. With the help of corporate sponsorships, government grants and the dedication of the local vendors and merchants, LLMA is committed to providing a fun and safe blues filled weekend to St. Louisans and visitors alike.
Event Properties
|Event Date
|08-30-2019 12:00 pm
|Event End Date
|Laclede's Landing


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Monumental Chocolate began from the question, "What would the world's most amazing chocolate bar look like?" It would be a huge, beautiful, gourmet masterpiece that one would not quickly forget. A perfect gift for chocolate lovers and friends.
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(2015-09-20, 12:16 AM)NathanTheSpaceSurvivor Wrote: Uhm, I noticed that Bifrost has SS paint when it should be LH. Does that count?
Nope. It's still fleet paint - ss is just easier to work with when sun is shining into my screen.
I posted screens with HUD turned on for a reason: speed 43, drag force 128k. I menaged to squize twice as many huge props inside.
That's the biggest change, it's even highlighted in red :p
The last one is size - four blocks longer - two for new props, two for improving hydrodynamics. It' quite visible - 7 "ribs" instead of 6, longer "neck"
When I finnish it, I'll use it as base for new Grim Reaper...


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If there was a game this year in which Calgary Stampeders' special teams most imposed their will on the opposition, last weekend's West Division semifinal could be that game.
The unit, which has had its share of lapses this season, limited vaunted B.C. kick returner Chris Rainey to ordinary yardage, while — in rather brisk conditions — punter Rob Maver did what he does best, working nicely in tandem with the coverage group.
"We just started focusing more on basic coverage principles and I'll leave that at that," explained Maver. "We're just playing with better technique, we're playing with more physicality. I was putting the ball where it needed to be more and guys were making tackles. It's not one thing, it's a combination of many. And everybody brought it that day. It's tough to return the ball when you have those things going against you."
"I think sometimes you can over-think things," pitched in special teams coach Mark Kilam. "I think we've just, as a whole, been trying to continue the positive momentum for our special teams and last week was another step in that progression and we're going to try to keep that going."
The wind can blow at any time of the year, but in November other factors can knock the stuffing out of the ball, literally, which just makes everyone's job just a little more stressful. In particular, the kickers.
"They (conditions) don't concern me because both teams have to play in it," Maver stated matter-of-factly. "If you looked at the type of football that's played in this weather, versus one in a dome or in the summer, it's tougher to execute skill positions in cold-weather games. Playoff games are great for our emotions and intensity, but it doesn't always necessarily showcase the finer points of the skill positions because it's tougher to execute.
"It's been a windy year," the six-year Stampeder continued. "We've played in a lot of these types of games. While it does make my job difficult and trying at times, it's something I'm very familiar with. It's just a matter of going out and doing what you have to do."
In Sunday's CFL West Final at Commonwealth Stadium in Edmonton — where the balmy forecast at this point promises mainly sunny, plus-5 with a 25 km/h wind — it'll be the versatile and shifty Kendial Lawrence whom Calgary will have to keep track of. The returner/slotback has had a terrific season, though the three games against the Stamps in 2015 weren't among his better outings.
"Every returner, they're all good," Maver submitted. "You have to be cognizant of the things they do individually, what separates them from other guys. But the principles don't change. Doing the things we're taught in the room across the hall, which I can't tell you."
"He's a very dynamic player," Kilam said of Lawrence, "both on offence and on special teams for them. He's been a focus in our meetings and what we need to do to control him. They're a formidable special teams unit; we're looking forward to the match-up."
Giving the offence great field position, likewise limiting the opposition … it all falls under the umbrella of momentum and in that, special teams will be critical.
"I think it's a result of what you're doing," suggested Kilam. "We deal in momentum-changing plays, positive and negative. We don't focus on that, we focus on our process and hope that the results take care of themselves."
If called upon to carry his squad's colours in the return game, former Eskimo Skye Dawson isn't using the chance to play his old team has any motivation.
"Being in the playoffs is extra motivation for me," said Dawson, who played three games earlier this year for the Esks. "It's not even about Edmonton. It's about being in the playoffs is crunch time. Everybody is buckled in, everybody's locked in, regardless of the team I'm playing against.
"No animosity with any of my old teammates. They're all good people, all good coaches … but it's going to be a fun game."


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Schädeli, David Lukas; Serricchio, Mauro; Ben Hamidane, Hisham; Loffreda, Alessio; Hemphill, Andrew; Beneke, Tom; Gluenz, Eva; Graumann, Johannes; Bütikofer, Peter (2019). Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome. FASEB journal, 33(12), pp. 13161-13175. Federation of American Societies for Experimental Biology 10.1096/fj.201901184RR
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The mitochondrial signature glycerophospholipid, cardiolipin (CL), binds to transporters of the inner mitochondrial membrane and plays a central role in formation and stability of respiratory supercomplexes. Functional and structural requirement of CL for mitochondrial membrane proteins has been studied in vitro using purified reconstituted proteins or in CL synthesis knockout cells that are viable under specific growth conditions. However, no information is available on mitochondrial function, protein stability, or expression levels in cells during CL depletion. In contrast to yeast and mammalian cells, CL synthesis is essential in Trypanosoma brucei. By stable isotope labeling with amino acids in cell culture and mass spectrometry, we analyzed protein levels in T. brucei procyclic forms at different time points during depletion of CL using tightly controllable conditional CL synthase knockout mutants and identified a set of novel CL-dependent proteins (CLDPs) with unknown functions. Depletion of individual CLDPs using knockout or knockdown technologies showed that although CL synthesis is essential, expression of a given CLDP is not. In addition, ablation of CL synthesis leads to respiratory supercomplex instability and altered mitochondrial ultrastructure and function. Our findings suggest that CL may bind to and affect many more proteins in eukaryotes than previously thought.-Schädeli, D., Serricchio, M., Ben Hamidane, H., Loffreda, A., Hemphill, A., Beneke, T., Gluenz, E., Graumann, J., Bütikofer, P. Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome.
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- Jacklyn Byrd Photography
1 Year Smash Cake / Ethan / Washington, Illinois / Jacklyn Byrd Photography
This little man turned one last week! He enjoyed his monster cake from Le Bakery. I loved watching him enjoy his cake and play with his balloons. I am blessed to be able to capture this adorable family!
Jacklyn Byrd Photography is located in Central Illinois, specializing in documentary wedding photography and lifestyle family sessions.


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Christmas sweets in Turkmen style
Gingerbread toppers are a whole pastry history. The first reference to honey cakes dates back to the 350s BC. What can be said? People enjoyed sweets at all times.
And when should the most delicious gifts for Christmas prepared? Resident of Ashgabat Olga Dolinskaya, lover of beautifully decorating her house and preparing treats personally, knows this very well.
Once a woman had an idea to paint ginger and honey toppers (in other words, gingerbread cookies on a stick) in a national style. Such a treat is akin to a work of art, which is a pity to eat, so as not to spoil the beauty. Intricate patterns, caravans of camels and even tamdyr are skillfully fashioned by a craftswoman from dough. What inspires her to create such original treats?
– I spent my childhood in Turkmenistan, and I grew up here and absorbed a love for bright national color. There are paintings in my house by famous Turkmen artist Kosek Nurmuradov, whose original characters inspired me to create a whole series of gingerbread cookies imitating the painter's style. My first gingerbread toppers were far from ideal, until I attended a master class, where I learned some cooking secrets, Olga says.
Now the hostess herself is giving demonstration lessons on the preparation of sweet treats, and, by the way, the process of baking such gingerbread cookies is not fast. It takes several days to create an edible "masterpiece".
As the first step dough is kneaded and kept for a certain time in the refrigerator. Then it is baked, and only the next day it is coated with glaze. The third step is the most entertaining part – painting and tinting. Ready-made gingerbread cookies are very large, similar to toys, and many do not believe that they can be eaten.
By the New Year's Holiday, Olga created a gingerbread Christmas wreath, which was decorated with a cotton boll, snowflakes and New Year's stars. The woman admits that her one else passion is brooch in the national style. These edible "jewelry" pieces are also in the collection of her products.
No, Olga is far from an artist, and she attended the drawing circle only in childhood. But the love for painting and cooking was reflected in her current original creative occupation. Each gingerbread is painted by hand, and before appearing as a sweet treat, its paper sketch is made.
Olga adds spices to honey toppers: cinnamon, cardamom, ginger. By perfecting her skills, the woman admits that over three years of her passion for baking, trial and error, she gained personal secrets of cooking. Even Olga's first culinary mentors admitted that she managed to surpass them in skill.
– In the New Year, I would like to wish everyone to bake something tasty with the whole family. Do not be afraid of involving children in cooking; let everyone contribute to the preparation of treats for the New Year's table. Do not even think to be upset if something does not work out, as the most important thing is that this is done with your own hands.


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Data Governance Market by Application (Incident Management, Process Management, Compliance Management, Risk Management), Business Function, Component, Deployment Model, Organization Size, Industry Vertical, and Region - Global Forecast to 2023
The data governance market size is estimated to be USD 1.31 billion in 2018 and is expected to reach USD 3.53 billion by 2023, growing at a Compound Annual Growth Rate (CAGR) of 22.0% during the forecast period. The rapidly increasing growth in data volumes, rising regulatory and compliance mandates, and enhancing strategic risk management and decision-making with the increasing business collaborations are expected to propel the growth of the data governance market.
Among various applications, the compliance management application segment is expected to grow at the fastest rate, due to the fact that compliance management applications enable organizations to test, remediate, attest, and manage their corporate structure. Compliance management applications enable organizations to implement, manage, monitor, and measure the effectiveness of their governance and compliance strategies. In addition to this, cloud-based compliance management applications provide organizations with all the necessary tools for creating an effective internal management system. The collaborative workspace helps process managers in determining organizations' compliance level.
The retail and eCommerce industry vertical is expected to grow at the highest CAGR during the forecast period, as it is creating large volumes of data which is ultimately driving the need for efficient data governance solutions in this industry vertical. The increasing demand for cross-border eCommerce and a high internet penetration in different regions are driving the retail and eCommerce industry vertical to adopt data governance technologies.
The Small and Medium-sized Enterprises (SMEs) segment is expected to achieve the fastest growth rate, primarily due to the surge in the adoption of customer data and product data applications across all regions. SMEs are focusing on deploying data governance solutions to secure their data and govern its usage as per the regulatory aspects. Companies launch cost-effective data governance solutions to cater to SMEs and meet their requirements.
Data governance solutions and services have become essential for the IT department of organizations, as it plays a vital role in improving the reliability, security, sustainability, and performance of organizations. The finance business function segment is expected to be the highest revenue generator during the forecast period. The finance department engages in measuring and improving the financial performance of organizations. Companies have to continuously monitor different regulatory requirements set by regional government authorities. Such vigilance enables companies to avoid non-compliance penalties imposed by regulatory authorities.
North America is expected to dominate the data governance market throughout the forecast period, owing to the early adoption of technologies and the presence of a large number of data governance solution providers. Asia Pacific (APAC) is expected to grow at the highest CAGR during the forecast period. The increasing digitalization and investment in infrastructure upgrades have resulted in the higher adoption of data governance and data management solutions. APAC is witnessing the increasing demand for cloud-based solutions, owing to the growing size of SMEs. Companies operating in this region provide different solutions based on organization size and their requirements.
Learn how to effectively navigate the market research process to help guide your organization on the journey to success.Download eBook


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1. GoPro Hero
1. GoPro Hero
What! You said under £30. That we did, but this one was just asking to be posted. GoPro recently released their new Hero 4 which you can get for a staggering £369.99, however this little gem also slipped the radar, the GoPro Hero Original. We take it that GoPro were a little worried about the low budget cams taking over, so they pretty much stole the show with this.
Coming in at £99 and all the bells and whistles most of us mere mortals need, it is almost a steal. If you are into your slowmo deep underwater then it's 60fps at 40 meters should suffice and if quality is an issue well it need not be because you'll find that you can shoot at 1080p or 720p, which gives us enough juice for any online webclip or home video.
What about the price? Nothing like a good old fashioned organised split between 3/4 friends/family members.


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Just 20 minutes north of Whistler is Nairn Falls Park. This park provides a good base camp for exploring Whistler, the Pemberton Valley or nearby Garibaldi Provincial Park. It is an excellent overnight stop before continuing onto the Duffey Lake Road or points north or south. The falls are 60 m high and a 1.5 km hiking trail will take you to the viewpoint. Off Hwy 99, approximately 92 km from Squamish, 32 km north of Whistler.
© 2017 Travel.bc.ca Online Inc.


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Now showing items 1-1 of 1
An analysis of Scotia-Fundy vessel users and what this means for the North Atlantic right whales
The North Atlantic right whale is endangered under the Species at Risk Act thus, its protection is of the utmost importance. In Canada, there are two ship strike mitigation measures. A voluntary area to be avoided in Roseway ...


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Art Movements
Abstract Expressionism, Impressionism and Pop Art
Abstract Expressionism
Abstract expressionism was an American post-World War II art movement. It was the first specifically American movement to achieve worldwide influence and also the one that put New York City at the center of the art world, a role formerly filled by Paris.
Although the term "abstract expressionism" was first applied to American art in 1946 by the art critic Robert Coates, it had been first used in Germany in 1919 in the magazine Der Sturm, regarding German Expressionism. In the USA, Alfred Barr was the first to use this term in 1929 in relation to works by Wassily Kandinsky.[1]
Like all Modern art, a general term used for most of the artistic production from the late Nineteenth century until approximately the 1970s, works of art created during this period reflect a new approach to art which placed emphasis on representing emotions, themes, and various abstractions. Artists experimented with new ways of seeing, with fresh ideas about the nature, materials and functions of art, often moving further toward abstraction.
In Expressionist Art, the artist tries to express certain feelings about some thing. The artists that painted in this style were more concerned with having their paintings express a feeling than in making the painting look exactly like what they were painting.
Marc Chagall , Wassily Kandinsky , Ludwig Kirchne
Impressionism was developed in France during the late 19th and early 20th centuries. These pieces of art were painted as if someone just took a quick look at the subject of the painting. The paintings were usually in bold colors and did not have a lot of detail. The paintings in this style were usually outdoor scenes like landscapes. The pictures were painted to look like they were shimmering.
Characteristics of Impressionist paintings include relatively small, thin, yet visible brush strokes; open composition; emphasis on accurate depiction of light in its changing qualities (often accentuating the effects of the passage of time); common, ordinary subject matter; the inclusion of movement as a crucial element of human perception and experience; and unusual visual angles. The development of Impressionism in the visual arts was soon followed by analogous styles in other media which became known as Impressionist music and Impressionist literature.
The term "Impressionism" can also be used to describe art created in this style, but not during the late 19th century.
Claude Monet, Mary Cassatt, Pierre Auguste Renoir, Camille Pissaro.
Pop Art
Pop Art, born slightly after the Abstract Expressionist movement, is seen by many as both a reaction and an expansion on the ideas which that movement was presenting. The idea of Pop Art is one which seeks to challenge traditional approaches to art. The definition of Pop Art maintains that when an artist uses an image or theme that is a mass-produced quantity, their work is still valid and should be classified as Fine Art because they are removing any of the original meaning from the context and are making a unique statement with the materials which they use. The entire idea behind Pop Art does not relate so much to the art itself as to the attitudes of the artists about the pieces.
Pop Art has roots with Pop Music as well, with the movement toward expressing popular ideas and beliefs instead of the more traditional elitist views toward beauty in art and life. Both elements make heavy use of irony while making their points. It is usually seen as a way of responding to the personal symbolism that Abstract Expressionism brought, making art more accessible to the public with impersonal works filled with irony and parody to make a point.
Though it began in America during the late 1950s, Pop Art took its strongest hold during the 60s, when artists such as Roy Lichtenstein, Jasper Johns, and Andy Warhol had found a place in the art world. Due to the absorbing of modern art into the increasingly sophisticated advertising world, the American public didn't have a far leap to make into Pop Art. The struggle with the artists came in the form of finding deeper meaning in the popular images of the day, an exercise which the public took very well to. The strength with which the artists imbued their work was forceful, however. The bold and striking images which came from the Pop Art movement are ones which can still find resonance today.
Pop art can be any every day item that is drawn in a brash and colorful way. Pop Art is short for Popular Art. It is inspired by comic strips, advertising, and popular entertainment.
Andy Warhol, Roy Lichtenstein, Claes Oldenberg , David Hockney
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Dr Ali is a pulmonary vascular and airway disease biology researcher. Specifically, he is interested in investigating the mechanisms that underpin development of pulmonary arterial hypertension (PAH), hereditary hemorrhagic telangiectasia (HHT) and asthma. His overarching goal is to discover improved therapies for individuals with the devastating form of the lung diseases.
His academic training and research experience across 4 nations and 3 continents have provided him with an excellent background in multiple biological disciplines including immunology, molecular biology, microbiology, and cell biology. He received a B.Sc in Biotechnology and Genetic Engineering in 2010 from Khulna University, Bangladesh, an M.Sc. in Systems Biotechnology in 2013 from Chung-Ang University, South Korea, and a PhD in Immunology and Microbiology in 2018 from the University of Newcastle, Australia. Work that he carried out during his PhD on iron and lung disease has been published in the prestigious journals, including Eur Respir J, J Pathol, and received significant media attentions (Picked up by > 10 news outlets so far) and formed the basis for one project grant. In Nov 2018, he joined Spiekerkoetter laboratory at Stanford to identify clinically significant novel bone morphogenic protein receptor 2 (BMPR2) signaling modifier genes that could be targeted with repurposed drugs to increase BMPR2 expression and signaling, one of the key pathways and potential master switch in PAH. In addition, lessons from this related genetic disease (PAH), he has recently started to work on dysfunctional TGF-β/BMPR2 signaling in HHT that causes vascular malformations in different organs, including lung.
To date, he has published 11 original research articles, 2 review articles and >25 conference papers in top tier prestigious journals, including Eur Respir J, J Pathol, Am J Respir Crit Care Med, Cardiovascular Res (total citations 290, h index 6, as of June 2020). He has received 12 awards and scholarships so far. He has mentored 5 undergraduate and 1 junior PhD students, demonstrated immunology and microbiology lab course for 3 years. He is working as a reviewer for prestigious journals and member of 12 scientific organizations. He is also working as a Co-Director of Stanford Cardiovascular Institute Postdoc Conference 2020.
Beyond academic professional life, he enjoys traveling, playing and watching cricket, watching movies.
Research interest:
1.Targeting BMPR2 signaling modifiers in PAH with repurposed drugs
2.Role of long non-coding RNAs in BMPR2 signaling in PAH
3.Identifying common and unique downstream genes and signaling pathways of HHT causing gene mutations (ALK1, ENG, SMAD4)
4.Role of ferroptosis in the pathogenesis of asthma
Key expertise:
In vitro and in vivo lung disease modeling, airway/tissue remodeling, airway/lung inflammation, emphysema, lung fibrosis, lung function, FACS, immune cells phenotypic characterization, handling and production of Haemophilus, Pseudomonas, Chlamydia respiratory infection, bacterial recovery from blood, BAL fluid, and lung, primary lung epithelial, fibroblast, and endothelial cell and cardiac fibroblast culture, cell lines culture, cytotoxic assays, cell proliferation, apoptosis, cytokines detection, shRNA/siRNA-based gene silencing techniques, molecular cloning, gene manipulation, viral vectors, virus production, bacterial culture, transformation, protein expression, isolation, and purification, ELISA, western blot, phosphorylations; histochemical, immunohistochemical techniques (light, fluorescence, confocal microscopy), qPCR, RNAscope, bioinformatics tools such as Gene Trail, Go annotations and KEGG pathways, Panther, MGI, DAVID, STRING network analysis
Honors & Awards
PhD Award, The University of Newcastle, Australia (2018)
Travel Award, The Thoracic Society of Australia and New Zealand (TSANZ) Travel Award (2017)
Postgraduate Research Scholarship, The University of Newcastle, Australia (2014)
MS Award, Chung-Ang University, South Korea (2013)
Young Scientist Award, Chung-Ang University Young Scientist Award (CAYSS) (2011)
B.Sc Honors Award, Khulna University, Bangladesh (2009)
Merit Scholarship Award, Khulna University, Bangladesh (2008)
Boards, Advisory Committees, Professional Organizations
Member, American Thoracic Society (2020 - Present)
Member, World Association for Bronchology and Interventional Pulmonology (2018 - Present)
Member, European Respiratory Society (2017 - Present)
Member, The Thoracic Society for Australia and New Zealand (2016 - Present)
Member, International society for infectious diseases (2015 - Present)
Member, Asia Pacific Association of Pediatric Allergy, Respirology and Immunology (2015 - Present)
Member, International BioIron Society (2015 - Present)
Member, Priority Research Centre-Healthy Lungs, University of Newcastle, Australia (2014 - Present)
Professional Education
Master of Science, Unlisted School (2013)
Doctor of Philosophy, University Of Newcastle (2018)
Bachelor of Science, Unlisted School (2010)
Stanford Advisors
Edda Spiekerkoetter, Postdoctoral Faculty Sponsor
Additional Info
Current Research and Scholarly Interests
Pulmonary vascular remodeling, airway and lung remodeling, lung fibrosis
Novel BMPR2 modifiers with repurposing drugs, Stanford University (11/9/2018 - Present)
300 Pasteur Dr
All Publications
Critical role for iron accumulation in the pathogenesis of fibrotic lung disease.
The Journal of pathology
Increased iron levels and/or dysregulated iron homeostasis occurs in several lung diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis and associated lung function decline was investigated using a combination of murine models of iron overload and bleomycin-induced pulmonary fibrosis, primary human lung fibroblasts treated with iron and histological samples from patients with or without idiopathic pulmonary fibrosis (IPF). Iron levels are significantly increased in iron overloaded transferrin receptor 2 (Tfr2) mutant mice and homeostatic iron regulator (Hfe) gene-deficient mice and this is associated with increases in airways fibrosis and reduced lung function. Furthermore, fibrosis and lung function decline are associated with pulmonary iron accumulation in bleomycin-induced pulmonary fibrosis. We also show that iron accumulation is increased in lung sections from IPF patients and that human lung fibroblasts show greater proliferation, and cytokine and extracellular matrix responses when exposed to increased iron levels. Significantly, we show that intranasal treatment with the iron chelator, deferoxamine (DFO), from the time when pulmonary iron levels accumulate, prevents airway fibrosis and decline in lung function in experimental pulmonary fibrosis. Pulmonary fibrosis is associated with an increase in Tfr1+ macrophages that display altered phenotype in disease and DFO treatment modified the abundance of these cells. These experimental and clinical data demonstrate that increased accumulation of pulmonary iron plays a key role in the pathogenesis of pulmonary fibrosis and lung function decline. Furthermore, these data highlight the potential for the therapeutic targeting of increased pulmonary iron in the treatment of fibrotic lung diseases such as IPF. This article is protected by copyright. All rights reserved.
View details for DOI 10.1002/path.5401
View details for PubMedID 32083318
Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma.
The European respiratory journal
Accumulating evidence highlights links between iron regulation and respiratory disease. Here, we assessed the relationship between iron levels and regulatory responses in clinical and experimental asthma.We show that cell-free iron levels are reduced in the bronchoalveolar lavage (BAL) supernatant of severe or mild-moderate asthma patients and correlate with lower forced expiratory volume in 1 s (FEV1). Conversely, iron-loaded cell numbers were increased in BAL in these patients and with lower FEV1/forced vital capacity (FEV1/FVC). The airway tissue expression of the iron sequestration molecules divalent metal transporter 1 (DMT1) and transferrin receptor 1 (TFR1) are increased in asthma with TFR1 expression correlating with reduced lung function and increased type 2 (T2) inflammatory responses in the airways. Furthermore, pulmonary iron levels are increased in a house dust mite (HDM)-induced model of experimental asthma in association with augmented Tfr1 expression in airway tissue, similar to human disease. We show that macrophages are the predominant source of increased Tfr1 and Tfr1+ macrophages have increased Il13 expression. We also show that increased iron levels induce increased pro-inflammatory cytokine and/or extracellular matrix (ECM) responses in human airway smooth muscle (ASM) cells and fibroblasts ex vivo and induce key features of asthma, including airway hyper-responsiveness and fibrosis and T2 inflammatory responses, in vivoTogether these complementary clinical and experimental data highlight the importance of altered pulmonary iron levels and regulation in asthma, and the need for a greater focus on the role and potential therapeutic targeting of iron in the pathogenesis and severity of disease.
View details for DOI 10.1183/13993003.01340-2019
View details for PubMedID 32184317
Targeting BMPR2 Trafficking with Chaperones - An Important Step Towards Precision Medicine in Pulmonary Arterial Hypertension.
American journal of respiratory cell and molecular biology
View details for DOI 10.1165/rcmb.2020-0130ED
View details for PubMedID 32339467
Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of PA de-banding.
Cardiovascular research
AIMS: The temporal sequence of events underlying functional right ventricular (RV) recovery after improvement of pulmonary hypertension-associated pressure overload are unknown. We sought to establish a novel mouse model of gradual RV recovery from pressure overload and use it to delineate RV reverse-remodeling events.METHODS AND RESULTS: Surgical pulmonary artery banding (PAB) around a 26G needle induced RV dysfunction with increased RV pressures, reduced exercise capacity and caused liver congestion, hypertrophic, fibrotic and vascular myocardial remodeling within 5 weeks of chronic RV pressure overload in mice. Gradual reduction of the afterload burden through PA band absorption (de-PAB) - after RV dysfunction and structural remodeling were established - initiated recovery of RV function (cardiac output, exercise capacity) along with rapid normalization in RV hypertrophy (RV/LV+S, cardiomyocyte area) and RV pressures (RVSP). RV fibrotic (collagen, elastic fibers, vimentin+ fibroblasts) and vascular (capillary density) remodeling were equally reversible, however reversal occurred at a later time-point after de-PAB, when RV function was already completely restored. Microarray gene expression (ClariomS, Thermo Fisher) along with gene ontology analyses in RV tissues revealed growth factors, immune modulators and apoptosis mediators as major cellular components underlying functional RV recovery.CONCLUSIONS: We established a novel gradual de-PAB mouse model and used it to demonstrate that established pulmonary hypertension-associated RV dysfunction is fully reversible. Mechanistically, we link functional RV improvement to hypertrophic normalization that precedes fibrotic and vascular reverse-remodeling events.TRANSLATIONAL PERSPECTIVE: The right ventricle (RV) in pulmonary arterial hypertension possesses a remarkable ability to recover after lung transplantation. Yet, some transplant centers prefer a heart-lung instead of lung transplantation when the RV function is severely impaired because knowledge is lacking whether fibrotic and vascular myocardial remodeling are completely reversible once the increased afterload burden is relieved. We have developed a mouse model to study gradual unloading of the RV and identified key molecular components and the timing of RV reverse-remodeling events with the ultimate goal to understand the RV recovery process and identify ways how to support the RV during recovery.
View details for DOI 10.1093/cvr/cvz310
View details for PubMedID 31738411
IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthma
ERS International Congress 2019 abstracts
View details for DOI 10.1183/13993003.congress-2019.PA3345
Impaired induction of Slc26a4 promotes respiratory acidosis and severe, steroid-resistant asthma
View details for Web of Science ID 000407750400106
Role for dysregulated iron in the pathogenesis of murine models of lung disease
View details for Web of Science ID 000407750400105
View details for Web of Science ID 000396791000117
View details for Web of Science ID 000396791000118
View details for Web of Science ID 000396791000125
Role of iron in the pathogenesis of respiratory disease.
The international journal of biochemistry & cell biology
2017; 88: 181–95
Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human respiratory infections and diseases. An increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies. Here we review the clinical and experimental evidence that highlights the potential importance of iron in respiratory diseases and infections.
View details for DOI 10.1016/j.biocel.2017.05.003
View details for PubMedID 28495571
Impaired Induction Of Slc26a4 Promotes Respiratory Acidosis And Severe, Steroid-Insensitive Asthma
View details for Web of Science ID 000400372502496
Role Of Increased Iron Levels In The Pathogenesis Of Lung Disease
View details for Web of Science ID 000400372501706
Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.
American journal of respiratory and critical care medicine
2017; 196 (3): 283–97
Severe, steroid-resistant asthma is the major unmet need in asthma therapy. Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the identification of therapeutic targets. Excessive nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and concomitant IL-1β responses occur in chronic obstructive pulmonary disease, respiratory infections, and neutrophilic asthma. However, the direct contributions to pathogenesis, mechanisms involved, and potential for therapeutic targeting remain poorly understood, and are unknown in severe, steroid-resistant asthma.To investigate the roles and therapeutic targeting of the NLRP3 inflammasome and IL-1β in severe, steroid-resistant asthma.We developed mouse models of Chlamydia and Haemophilus respiratory infection-mediated, ovalbumin-induced severe, steroid-resistant allergic airway disease. These models share the hallmark features of human disease, including elevated airway neutrophils, and NLRP3 inflammasome and IL-1β responses. The roles and potential for targeting of NLRP3 inflammasome, caspase-1, and IL-1β responses in experimental severe, steroid-resistant asthma were examined using a highly selective NLRP3 inhibitor, MCC950; the specific caspase-1 inhibitor Ac-YVAD-cho; and neutralizing anti-IL-1β antibody. Roles for IL-1β-induced neutrophilic inflammation were examined using IL-1β and anti-Ly6G.Chlamydia and Haemophilus infections increase NLRP3, caspase-1, IL-1β responses that drive steroid-resistant neutrophilic inflammation and airway hyperresponsiveness. Neutrophilic airway inflammation, disease severity, and steroid resistance in human asthma correlate with NLRP3 and IL-1β expression. Treatment with anti-IL-1β, Ac-YVAD-cho, and MCC950 suppressed IL-1β responses and the important steroid-resistant features of disease in mice, whereas IL-1β administration recapitulated these features. Neutrophil depletion suppressed IL-1β-induced steroid-resistant airway hyperresponsiveness.NLRP3 inflammasome responses drive experimental severe, steroid-resistant asthma and are potential therapeutic targets in this disease.
View details for DOI 10.1164/rccm.201609-1830OC
View details for PubMedID 28252317
Investigating antioxidant therapy for steroid-resistant asthma
View details for DOI 10.1183/13993003.congress-2016.PA570
View details for Web of Science ID 000443059701120
View details for Web of Science ID 000373102400213
Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection
2015; 79 (6): 943–51
Transportin 3 (TNPO3) is a member of the importin-ß superfamily proteins. Despite numerous studies, the exact molecular mechanism of TNPO3 in retroviral infection is still controversial. Here, we provide evidence for the role and mechanism of TNPO3 in the replication of prototype foamy virus (PFV). Our findings revealed that PFV infection was reduced 2-fold by knockdown (KD) of TNPO3. However, late stage of viral replication including transcription, translation, viral assembly, and release was not influenced. The differential cellular localization of PFV integrase (IN) in KD cells pinpointed a remarkable reduction of viral replication at the nuclear import step. We also found that TNPO3 interacted with PFV IN but not with Gag, suggesting that IN-TNPO3 interaction is important for nuclear import of PFV pre-integration complex. Our report enlightens the mechanism of PFV interaction with TNPO3 and support ongoing research on PFV as a promising safe vector for gene therapy.
View details for DOI 10.1080/09168451.2015.1008973
View details for Web of Science ID 000356239400011
View details for PubMedID 25660973
Nuclear localization signals in prototype foamy viral integrase for successive infection and replication in dividing cells.
Molecules and cells
2014; 37 (2): 140–48
We identified four basic amino acid residues as nuclear localization signals (NLS) in the C-terminal domain of the prototype foamy viral (PFV) integrase (IN) protein that were essential for viral replication. We constructed seven point mutants in the C-terminal domain by changing the lysine and arginine at residues 305, 308, 313, 315, 318, 324, and 329 to threonine or proline, respectively, to identify residues conferring NLS activity. Our results showed that mutation of these residues had no effect on expression assembly, release of viral particles, or in vitro recombinant IN enzymatic activity. However, mutations at residues 305 (R → T), 313(R → T), 315(R → P), and 329(R → T) lead to the production of defective viral particles with loss of infectivity, whereas non-defective mutations at residues 308(R → T), 318(K → T), and 324(K → T) did not show any adverse effects on subsequent production or release of viral particles. Sub-cellular fractionation and immunostaining for viral protein PFV-IN and PFV-Gag localization revealed predominant cytoplasmic localization of PFV-IN in defective mutants, whereas cytoplasmic and nuclear localization of PFV-IN was observed in wild type and non-defective mutants. However sub-cellular localization of PFV-Gag resulted in predominant nuclear localization and less presence in the cytoplasm of the wild type and non-defective mutants. But defective mutants showed only nuclear localization of Gag. Therefore, we postulate that four basic arginine residues at 305, 313, 315 and 329 confer the karyoplilic properties of PFV-IN and are essential for successful viral integration and replication.
View details for DOI 10.14348/molcells.2014.2331
View details for PubMedID 24598999
View details for PubMedCentralID PMC3935627
Comparative sequence and expression analyses of African green monkey (Cercopithecus aethiops) TNPO3 from CV-1 cells
2013; 35 (4): 549–58
View details for DOI 10.1007/s13258-013-0102-8
View details for Web of Science ID 000322725200015
Structural and Functional Insights into Foamy Viral Integrase
2013; 5 (7): 1850–66
Successful integration of retroviral DNA into the host chromosome is an essential step for viral replication. The process is mediated by virally encoded integrase (IN) and orchestrated by 3'-end processing and the strand transfer reaction. In vitro reaction conditions, such as substrate specificity, cofactor usage, and cellular binding partners for such reactions by the three distinct domains of prototype foamy viral integrase (PFV-IN) have been described well in several reports. Recent studies on the three-dimensional structure of the interacting complexes between PFV-IN and DNA, cofactors, binding partners, or inhibitors have explored the mechanistic details of such interactions and shown its utilization as an important target to develop anti-retroviral drugs. The presence of a potent, non-transferable nuclear localization signal in the PFV C-terminal domain extends its use as a model for investigating cellular trafficking of large molecular complexes through the nuclear pore complex and also to identify novel cellular targets for such trafficking. This review focuses on recent advancements in the structural analysis and in vitro functional aspects of PFV-IN.
View details for DOI 10.3390/v5071850
View details for Web of Science ID 000322172200016
View details for PubMedID 23872492
View details for PubMedCentralID PMC3738965


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text: PNWguy 2,020 Posted December 8, 2018 I'm on a couple of other firearms forums and it seems with every thread involving a Glock pistol or one in which the virtues of a Glock pistol are mentioned, there will be a few people that have so much hate and personal vitriol towards Glocks that they have to chime in and rant. I don't get it. There are dozens of striker-fired polymer pistols on the market today and most are very similar to the Glock pattern, yet mention you bought a new Beretta APX and crickets. Mention you bought a Glock and people will start making snide comments about tupperware and kool-aid(?). They remind me of people who hate Donald Trump. Any mention of the name and they are triggered and HAVE to make a snide comment. I don't get the need for the snide comments in every Glock thread. I happen to think that the 1911 is a great pistol with some great attributes, but on paper, it is a horrible choice for CCW due to weight, capacity, and unreliability. Yet I have never gone into a thread that someone is bragging about their new $2500 1911 (although it's having feeding issues, it will break-in after a few hundred rounds...) and start dragging it down. I think 90% of Glock haters are over 60, divorced, from the Southern half of the United States, and probably voted for Buchanan... 2 1 1 Quote Share this post Link to post Share on other sites


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