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B7‑H4 overexpression correlates with a poor prognosis for cervical cancer patients
- Authors:
Affiliations: Bell Research Center for Reproductive Health and Cancer, Kishokai Medical Corporation, Nagoya, Aichi 458‑0801, Japan, Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Bio‑Databases Institute of Reproductive and Developmental Medicine, Nagoya, Aichi 458‑0801, Japan, Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan
- Published online on: December 12, 2013 https://doi.org/10.3892/mco.2013.225
- Pages: 219-225
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Cervical cancer develops from the cells that constitute the cervical epithelium and involves an abnormal increase in the number of immature cells in this region. Cervical cancer is the second most commonly diagnosed malignancy among females worldwide according to the International Federation of Gynecology and Obstetrics (FIGO) (1). Despite the generally favorable prognosis of early cervical cancer patients, approximately one-third of these patients eventually succumb to the disease.
The optimal treatment selection for cervical cancer is multidisciplinary and is based on several factors, including patient age, histological subtype, tumor grade, stage and lymph node status, depth of stromal invasion and lymphovascular space invasion (LVSI). The immunoresponse was also identified as an important prognostic factor for survival in cervical cancer (2). B7 family members and their receptors are crucial in the regulation of antigen-specific immune responses (3).
The modulation and suppression of antitumor immune response is a characteristic that enables tumor cells to escape immune surveillance. Members of the B7 family are involved in this process, since the level of activation of the antitumor immune response depends on the balance between co-stimulatory and co-inhibitory signals. Certain molecules, which are often overexpressed in tumors, have been associated with the pathogenesis and progression of malignancies, as well as their immunological and non-immunological functions. The B7 homologs play a key role in the maintenance of self-tolerance and regulation of innate and adaptive immunity in tumor-bearing hosts (4).
B7-H4 (also known as B7× and B7S1) is the most recently identified immunoregulatory member of the B7 family (3,5,6). B7-H4 has been implicated in the inhibition of T-cell-mediated immunity and the downregulation of the T-cell response through the inhibition of T-cell proliferation, cytokine production and cell cycle progression (3,7,8). Although the expression of B7-H4 is characteristic in lymphoid cells, B7-H4 mRNA is highly expressed in human breast and ovarian cancers, but not in the majority of normal tissues (9–11). Aberrant B7-H4 expression was also demonstrated in the cancer cells of patients with various malignancies, such as melanoma, ovarian, gastric and non-small-cell lung cancer, renal cell carcinoma, esophageal and endometrial cancer, and its expression was found to be correlated with the progression of the disease (7,8,11–18). Cervical cancer is difficult to detect early and it may also occur at a young age. While early detection improves the cure rate, the stage at diagnosis remains one of the most significant prognostic factors. Therefore, it is crucial to identify novel biomarkers for early detection and new targets for the treatment of cervical cancer. B7-H4 is reportedly overexpressed in early-stage ovarian cancer and is independent of CA125, suggesting that B7-H4 may be a novel biomarker (19).
B7-H4 was shown to be a prognostic maker in various tumors, although the correlation between B7-H4 expression and the prognosis of cervical cancer has not been fully elucidated. In this study, we measured the B7-H4 expression intensity in cervical cancer tissues using an immunohistochemical method and the association of B7-H4 expression with clinicopathological parameters and the intensity of expression was analyzed. B7-H4 may serve as a novel prognostic predictor for human cervical cancer and is also a potential target for therapeutic intervention.
Materials and methods
Tissue samples
Tissues were obtained from 102 patients who underwent surgery at the Nagoya University Hospital. The age of the patients ranged between 23 and 80 years, with a median age of 50 years. Patients who underwent pre-operative treatment, such as radiotherapy and/or chemotherapy, were excluded. All tissue samples were fixed in 10% formalin, embedded in paraffin and routinely stained with hematoxylin and eosin for histological examination.
Immunohistochemical B7-H4 staining and evaluation
Formalin-fixed, paraffin-embedded tissue blocks were cut into 4-mm sections and mounted on charged glass slides, deparaffinized and rehydrated in a graded series of ethanol. Antigen retrieval was performed in 1 mmol/l EDTA solution (Nacalai Tesque Inc., Kyoto, Japan) (pH 8.0) at 98ºC for 15 min. Endogenous peroxidase activity was blocked with 3.0% hydrogen peroxide (Wako, Osaka, Japan) for 5 min at room temperature. Blocking was performed in 10% normal goat serum (NGS; DakoCytomation, Glostrup, Denmark) with 1% bovine serum albumin (Sigma-Aldrich, St. Louis, MO, USA) in Tris-buffered saline (TBS) with 0.025% Tween-20 (TBS-T, Kanto Chemical Co., Inc., Tokyo, Japan) for 60 min. The sections were incubated with anti-B7-H4 rabbit monoclonal antibody in blocking buffer at 4ºC overnight (clone EP1165; Abcam, Cambridge, MA, USA). After three washings, the sections were incubated with biotinylated goat anti-rabbit horseradish peroxidase for 60 min at a 1:500 dilution, followed by incubation with avidin-biotin complex reagent for 30 min at a 1:100 dilution (PK-4001; Vector Laboratories, Burlingame, CA, USA) and finally visualized with 3,3′-diaminobenzidine (DAB peroxidase substrate kit, SK-4100, Vector Laboratories) in Milli-Q purified water (Millipore, Billerica, MA, USA). The slides were counterstained with Mayer's hematoxylin (Wako). The sections were dehydrated, cleared and mounted. Negative controls were run on all sections with 3% NGS in TBS-T, generated against unrelated antigens. The intensity of immunostaining for B7-H4 was scored as 0 (negative), 1 (weak), 2 (medium) and 3 (strong).
Statistical analysis
The association between negative vs. positive B7-H4 expression and the clinicopathological parameters was evaluated using χ2 tests. The various clinicopathological parameters were evaluated using the Kaplan-Meier method by univariate survival analysis. The comparison between the survival curves was analyzed using the log-rank test for differences in overall patient survival. The overall survival (OS) was defined as the time between the date of surgery and last date of follow-up or date of death from cervical cancer. The disease-free survival (DFS) was defined as the time interval between the date of surgery and date of recurrence or that of the last follow-up. The prognostic significance of B7-H4 expression according to other pathological variables was assessed using the multivariate Cox's proportional hazards analysis. Statistical analyses were conducted using free R software and P<0.05 was considered to indicate a statistically significant difference.
Immunohistochemical detection of B7-H4 in cervical cancer tissues
A total of 102 cervical cancer specimens were investigated in this study and 71 (69.6%) were found to be positive for B7-H4 immunoexpression, of which 23 were strongly positive. B7-H4 was detected on the cell membrane as well as in the cytoplasm of cervical cancer cells (Fig. 1). In several cases, the expression of B7-H4 in the tumor stroma was found to be higher compared to that in tumor cells (Fig. 1C and D). There were also cases in which cancer involving vascular spaces exhibited strong B7-H4 staining (Fig. 1C and D). The strongly positive cases were included in positive cases for the statistical analysis. The association between B7-H4 expression and clinicopathological variables is shown in Table I. There was no significant correlation between the expression of B7-H4 and patient age, FIGO stage, histological type, LVSI, or lymph node status. Representative images of B7-H4 staining are shown in Fig. 1.
Figure 1
Immunohistochemical analysis of B7-H4 in cervical cancer. (A and B) Representative results of negative control expression in squamous cell carcinoma and vascular spaces; (C and D) the cancer cells involving vascular spaces were strongly stained in certain cases. Positive B7-H4 expression in (E) squamous cell carcinoma and (F) adenocarcinoma. Arrows, B7-H4 positivity expressed in the cytoplasm and on the membrane of cervical cancer cells; boxes, magnification of the respective areas indicated by the arrows.
Association of B7-H4 expression with the survival of cervical cancer patients
The median follow-up for all patients was 68 months (range, 4.8–169 months). Of the 102 patients, 20 (19.6%) had developed a relapse of cervical cancer at the time of the last follow-up and 16 (15.6%) eventually succumbed to the disease. The 5-year OS rate for patients who were negative (n=31) and positive (n=71) for B7-H4 expression were 94.7 and 78.4%, respectively (Table II). Fig. 2 shows the OS and DFS curves with respect to B7-H4 expression. The OS of B7-H4-positive patients was significantly lower compared with that of B7-H4-negative patients (P=0.014). The DFS in B7-H4-positive patients exhibited a tendency to be associated with positive B7-H4 expression, although this association was not significant (P=0.0813).
Figure 2
Kaplan-Meier survival curves for primary cervical cancer according to the immunoexpression of B7-H4. (A) Overall survival (OS). (B) Disease-free survival (DFS). Continuous line, negative B7-H4 expression (n=31). Discontinuous line, positive B7-H4 expression (n=71). The patients with tumors exhibiting B7-H4 expression had a significantly poorer carcinoma-specific survival (OS, P=0.0140; DFS, P=0.0813).
Table II
Univariate analysis of various clinicopathological parameters in relation to survival of patiens with cervical cancer.
In the univariate analysis, age, FIGO stage, positive LVSI and lymph node metastasis and positive expression of B7-H4 were found to be significant predictors of poor OS. Furthermore, FIGO stage and lymph node metastasis, which are prognostic factors of DFS, were significantly poorer in B7-H4-positive cases. Other factors, including age and LVSI, exhibited a tendency to be associated with DFS, although this association was not significant (Table II). Notably, with regard to OS and DFS, FIGO stage and positive lymph node metastasis were found to be more significant (P<0.01 and <0.001, respectively).
The cases were subdivided further into two groups according to their FIGO stage (early stage I–IIA and advanced stage IIB–IV). In the early-stage group, B7-H4 expression was significantly associated with prognosis (P=0.0372) (Fig. 3A). However, in the advanced-stage group, B7-H4 expression was not significantly associated with prognosis (P=0.207) (Fig. 3B).
Figure 3
Carcinoma-specific overall survival rate of cervical cancer patients with tumors exhibiting B7-H4 expression. Kaplan-Meier survival curves for primary cervical cancer according to the immunoexpression of B7-H4 stratified by International Federation of Gynecology and Obstetrics (FIGO) stage and histological type. (A and B) Kaplan-Meier survival curves stratified by FIGO stage (A, stages I–IIA and B, stages IIB–IV). (C and D) Kaplan-Meier survival curves stratified by histological type (C, squamous cell carcinoma and D, adenocarcinoma). Continuous line, negative B7-H4 expression. Discontinuous line, positive B7-H4 expression. Stage I–IIA, IIB–IV and squamous cell carcinoma exhibiting B7-H4 expression had a significantly poorer carcinoma-specific survival (P=0.0372, 0.207 and 0.0341, respectively).
Similarly, all the cases were stratified according to histological subtype into squamous cell carcinoma (SCC) and adenocarcinoma (Fig. 3C and D). The expression of B7-H4 was a significant prognostic factor in SCC, but not in adenocarcinoma (SCC, P=0.0341 and adenocarcinoma, P=0.205). However, the squamous cell carcinoma subtype was a significant poor prognostic factor.
Multivariate analysis of prognostic variables in cervical cancer patients
As shown in Table III, in the multivariate OS analysis, age, FIGO stage, histological type, presence of LVSI, lymph node status and B7-H4 expression were included in the Cox proportional hazards analysis. The relative risk (RR) for positive B7-H4 expression was 10.34 and the 95% confidence interval (CI) was 1.345–79.478; P=0.025. Similarly, the multivariate analysis of DFS revealed that only the FIGO stage was a significant independent prognostic factor (RR=3.47; 95% CI: 1.263–9.551; P=0.016). However, age, histological type, LVSI, and lymph node status were not significantly associated. With regard to DFS, there was a difference between positive and negative expression of B7-H4, but it was not considered to be a significant independent prognostic factor, due to the narrow margin (RR=3.19; 95% CI: 0.903–11.247; P=0.072).
Table III
Multivariate analysis of several clinicopathological parameters in relation to survival of patiens with cervical cancer.
In the present study of 102 cervical cancer patients with a long-term follow-up, our results demonstrated that B7-H4 was highly and aberrantly expressed (71/102, 69.6%) and the B7-H4 expression level was not associated with any of the clinicopathological parameters. B7-H4 immunoexpression was evaluated based on stain intensity and area analysis. However, there was no significant association between B7-H4 expression and OS excluding intensity analysis. High B7-H4 expression was observed in a predominantly cytoplasmic and circumferential membranous distribution pattern. There was also limited immmunoreactivity for B7-H4 in the tumor stroma and perivascular area. Similar results were previously reported (20). In addition to tumor cells, tumor-infiltrating macrophages (8,15,21) and the endothelial cells of small blood vessels in the cancer microenvironment were also found to constitutively express B7-H4. B7-H4 was also found to be highly expressed on tumor-associated macrophages in the ascites of ovarian cancer patients and may contribute to tumor progression (15).
In our study, high tumor B7-H4 expression was associated with a poorer OS in the uni- and multivariate analysis of all the factors affecting survival. The correlation between B7-H4 expression and its clinical significance in patients with malignancies was previously described (7,10,11,15–17,20,22,23). Despite the unique patient populations, the differences in the antibodies used, the variations in the definitions of endpoints and the different pathologists evaluating the specimens, we independently obtained markedly similar results. Those studies suggested that aberrantly expressed B7-H4 was associated with adverse pathological characteristics and an increased risk of a poor prognosis or death from this disease. Our results demonstrated that cervical cancer patients with B7-H4-positive tumors exhibited a significantly worse OS compared to that of B7-H4-negative patients.
B7-H4 staining intensity was found to be associated with cancer spread along with clinical cancer recurrence and subsequent death. The invasion of lymphatic or blood vessels by carcinomatous cells is considered to be a critical step in the formation of lymphatic or distant metastasis. The involvement of lymphatic vessels is clearly an indicator of an unfavorable prognosis, even in early-stage cervical cancer. Tumor B7-H4 expression was also associated with lymphocytic infiltration, which predicts a poor clinical outcome for patients with cervical cancer (7). Furthermore, we observed that B7-H4 was associated with a significantly increased mortality risk in cervical cancer patients with pathologically localized cervical cancer tumors in the univariate analysis. Although FIGO stage, LVSI and lymph node metastasis were not identified as significant independent prognostic factors, they tended to be associated with poor prognosis. B7-H4 expression in cervical cancer patients is an independent prognostic predictor of the clinical outcome.
The role of B7-H4 has not been clearly determined and functional analyses are currently difficult to perform. B7-H4 was demonstrated to be a negative regulator of T-cell responses and to render tumors cells refractory to apoptosis (9,13). Regarding the underlying mechanism, one possible explanation is that B7-H4 expression inhibits T-cell proliferation, decreases cytokine secretion and prevents apoptosis (8,13). Two studies demonstrated that the overexpression of B7-H4 in human ovarian cancer cell lines promoted tumor formation in severe combined immunodeficiency mice, whereas short interfering RNA-mediated knockdown of B7-H4 mRNA and protein expression in a breast cancer cell line enhanced intracellular caspase activity, leading to the acceleration of tumor cell apoptosis (9,24). Furthermore, B7-H4 was shown to affect the immune response to and the outcome of lethal pulmonary infection (25) and induce donor-specific tolerance following transplantation (26,27). Therefore, B7-H4 may also be used as an immunotherapeutic target against malignancies.
In conclusion, in this study, we presented evidence supporting the role of B7-H4 as an independent prognostic predictor of clinical outcome in cervical cancer patients. Further functional experiments may elucidate the molecular mechanism underlying the effect of B7-H4 on the prognosis of cervical cancer. Furthermore, B7-H4 may be a novel target for molecular-targeted therapy against cervical cancer.
The authors would like to thank Dr Luo and Ms. Daimon for their laboratory support.
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A recent church sign read, "Come as you are." Without being antagonistic, something struck me as inconsistent with the scripture. When God called out to Moses in a burning bush, Moses could not come as he was, for God told him to take off his shoes, "for the place whereon thou standest is holy ground." God would not allow the priests to enter the holy place in their normal apparel, nor did He condone the children of Israel acting as the heathen nations. David wrote, Psalm 4:3 "But know that the LORD hath set apart him that is godly for himself" which meant that God desired a change of mind and actions of those whom He had called.
To be fair, "Come as you are" can be taken as an invitation to simply come to worship without the pressure of being perfect. Of this I am in favor. There are no prerequisites to come to God. People need to know that they can come to the service and seek God regardless of their appearance or background.
Yet in these later times "Come as you are" actually means, "you don't have to change anything about yourself to serve God." This is not congruent with the holy writ as Paul said that we would become a new creature; that old things would pass away and a new life would begin. That was the whole point of conversion. Even Jesus said, "When thou art converted, strengthen the brethren."
Changing from an old nature into the image of Jesus Christ was the purpose of the New Birth experience. Christianity was never meant to imply "come as you are" without the idea that God would require steps of transformation. He wants us to come, but His desire is for us to change into the image of His Son, Romans 8:29. So when we come to Him, we must know that the place where we stand is Holy Ground and it might require us to "take off our shoes."
Pastor Jeffrey Harpole

subset: commoncrawl


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Merryweather Stark – Carved In Rock
Neil Merryweather – Bass/Vocals, Janne Stark – Guitar/Bass, Peter Svensson – Drums
Irma la Douche starts with some excellent lead work and pounding drum with thundering bass get ready to just rock out. It Aint Pretty rumbling bass crunchy chords and solid drums kick back and enjoy. We Got To Own This Thing is excellent blues hard rock with lots of soul and emotion. Babylon Sin City take a trip back to the seventies and some great jamming music. Give Em Hell Boy get out the air guitar and air drums and just play along to one catchy song fist in the air. Rockers Lament hope in your car or on your bike crank up this tunes and just speed down the highway. Lay Your Body Down fist in the air bodies swaying to this bluesy rhythm. Love And War another trip back to the sixties and some great tunes. Freedom To Love kick back close your eyes and just drift along to some awesome musicianship. What's It Gonna Be some excellent late sixties Mahogany Rush influenced music with great vocals. I Believe grab your guitar and just jam along to a soulful song.
Grand Design – Viva la Paradise
Pelle Saether – Vocals, Janne Stark – Guitar, Dennis Vestman – Guitar, Stefan Westerlund – Bass, Joakim Jonsson – Drums
Face It has the sounds of bikes racing down the road then a excellent riff that just sticks in your head. Rock N Roll Hysteria fist in the air head banging hair flying as the crowd just get into the groove singing along. Viva La Paradise melodic lead guitar that just pierces the soul with some excellent playing and great vocals. Don't Ice Me Out this would be a great song live to get the crowd bouncing and swayin with fist in the air. Aim For The Heart nice melodic guitar and vocals that just lift your soul just a great power ballad. I Would Be The Wind cruising down the road music blasting on a trip to who knows where. Love Shouldn't Hurt is a very melodic heart felt that just reaches inside and grabs your very soul. Its Only Straight From The Heart crowd bouncing fist pumping sing along hard rock. Too Late To Fall In Love get your fist hi and rock out as you sing along and just jam away. U Can't Fool Love grab your air guitar and just jam along with one very catchy song with excellent musicianship and vocals.
Hazemaze - ST
Ludvig Andersson – Guitar / Vocals, Stefan Carillo – Bass, Nils Eineus – Drums
Wall Of Confusion slow Sabbath style bass and drums with a piercing guitar with loads of emotion. Lord Cubensis close your eyes and just move to the slow psychedelic stoner rock rhythm and excellent vocals. Black Mamba Pt1 take a trip back to the early days of stoner rock and just trip with the music. Black Mamba Pt2 these guys were definitely influenced by the mighty Sabbath slow song that just plod along but never get boring. Minds Abyss take a dark journey thru your very mind. Lies slow bass riffs fill the air then psychedelic guitars and pounding drum to just take a long journey along with. Beast And Prey is slightly more up tempo but not music just rock out and enjoy. Searching great bass playing that just rumbles your insides guitar that just works its way thru you and drums that just pound into your very being with vocals that take you on a strange trip.
The Heavy Eyes – Live In Memphis
Trip Shumake – Guitar/Vocals, Wally Anderson – Bass, Eric Garcia – Drums
Mannish Boy live stoner rock with a very bluesy feel that just makes you wanna move. Maggie searing guitar that takes you back to the late 60s and solid rhythms. Iron Giants close your eyes and just take a trip thru your musical mind. Parado is a very laid back blues based hard rock psychedelic song that just remind some of us of the great old music. Shadow Shaker move and sway to the excellent heartfelt guitar then a rhythm that envelopes your entire essence. Super Moon the crowd will be moving and swaying to a riff that will just stick in your head for days. Saint sing along and fist pump to one catchy song with some excellent musicianship. These Men Are Wolves rollin drums thundering bass and a great song that takes you on a interesting trip. One Hand On The Buffalo get your air guitars out and get ready to jam with a song that has a very Cream influence mixed with Sabbath. The Fool bass that just overtakes your very essence then a slow plodding trip thru strange times. Voytek music slowly rising out of the darkness and surrounding you taking you on a trip thru maybe the swamps or some other backwoods place. Goodnight is a great song to end this blues based festival of psychedelic notes. Catfish Blues one last stoner song about being a catfish you figure it out.
Khorada – Salt
Don Anderson – Guitar, Jason Walton – Bass, Aesop Dekker – Drums, Aaron John Gregory - Guitar/Vocals
Edeste has a sort of spaghetti western feel then a slow steady beat with an almost gothic feel. Seasons Of Salt will take you mind on a strange trip thru the darkness of the black abyss then just pound you into dust. Water Rights evil rises and just envelopes you taking you into the very pits of hell. Glacier Gold sounds of a storm then a very melancholy gothic feel that just works its way along the musical path. Augustus starts out more melodic with a very eerie feel. Wave State strange and eerie jazz meets death meets gothic. Ossify taking a strange trip thru the nether world.


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News release
TSB issues update on 2016 safety Watchlist: "Stakeholders are definitely taking notice"
Gatineau, Quebec, 3 May 2017 —Delivering on last fall's promise of a more proactive approach, the Transportation Safety Board of Canada (TSB) issued an update Wednesday, highlighting recent meetings with key stakeholders concerning the Board's safety Watchlist.
TSB Chair Kathy Fox said that, rather than wait for improvements that can sometimes take years to occur, TSB investigators and senior officials have spent the past six months actively engaging federal and provincial leaders, as well as industry executives, to push for concrete action on what the Board sees as the most important safety issues facing Canada's transportation network.
"We're not just looking at Transport Canada," said Fox. "We've also met with individual railways, airport authorities, industry associations, the Department of Fisheries and Oceans, and various senior government officials at the federal and provincial level. In other words, it's about getting our message across to as many decision-makers as possible, from coast to coast."
Fox said most of the meetings have been targeted so that particular issues are raised with those best-placed to take action. Discussions with executives at Toronto and Vancouver's major airport authorities, for example, focused on the issue of avoiding collisions on the runway and runway overruns. Meetings aimed at improving commercial fishing safety, meanwhile, were held with provincial officials in PEI, including the Department of Justice, the Department of Agriculture and Fisheries, and that province's Workers Compensation Board. Similar meetings were also held with officials and associations in New Brunswick, British Columbia, and Quebec.
Given that rail safety issues—such as the transportation of flammable liquids, following signal indications, fatigue management and the use of onboard recorders—comprise almost half the Watchlist, Fox said the TSB has also pushed hard for action in this area. Investigators, executives, and members of the Board have met with groups including some railways, the Railway Association of Canada, and the Canadian Association of Railway Suppliers. In each case, said Fox, "stakeholders are definitely taking notice."
"Some organizations are sharing Watchlist information on their websites and, after talking to us, many are now engaging in conversations of their own."
Although Fox characterized the reaction of the past few months as "positive," she acknowledged that many challenges remain which may influence progress and the TSB must continue with its proactive efforts. She also said the Board will consider more updates in future, as necessary—both to keep Canadians informed and to hold stakeholders accountable for their commitments. "We promised to report publicly, so that's exactly what we're going to keep doing."
The TSB is an independent agency that investigates air, marine, pipeline, and rail transportation occurrences. Its sole aim is the advancement of transportation safety. It is not the function of the Board to assign fault or determine civil or criminal liability.
For more information, contact:
Transportation Safety Board of Canada
Media Relations
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text: On 2007-01-11 00:29, "Lion G." <liontanker at hotmail.com> wrote: > Hi all, I have a weird question. > > In my previous many laptops, whenever I plug in the earphone, the > laptop speaker would stop (and I would only hear music through the > earphone) Which is what *should* happen. After all, when you plug headphones into the proper jack, it's a sort of 'signal' that you want to hear something without disturbing all the people around with it too :) When I asked: "Is automute of headphone/speakers always handled by the snd_hda driver?" Ariff explained why this happens to me by writing: "It all depends on the internal wiring, codecs, vendor preferences, etc, but mostly yes, it is handled by the driver itself: cheaper, flexible." > With my newest laptop (Acer Aspire 5050), the laptop speaker stays on > no-matter-what. I would hear the same music in both the speaker and > the earphone. > > I'm using Ariff Abdullah's snd_hda driver on 6.2-RC2. > The driver reports: > pcm0: <ATI SB450 High Definition Audio Controller> mem > 0xc0000000-0xc0003fff irq 16 at device 20.2 on pci0 > pcm0: <HDA Codec: Realtek ALC883> > pcm0: <HDA Driver Revision: 20061210_0037> Try contacting Ariff. He is pretty responsive and he will most probably reply with a patch that fixes the problem for you. This is *exactly* what happened when I asked him about my own laptop, a Toshiba Satellite U200, which had the same 'bug'. The fix for my laptop is now part of FreeBSD 7.0-CURRENT: http://www.freebsd.org/cgi/cvsweb.cgi/src/sys/dev/sound/pci/hda/hdac.c?rev=1.21&content-type=text/x-cvsweb-markup Before contacting Ariff, it will be helpful (and will save you at least one round-trip of email exchanges), if you boot in ``verbose mode'', and save a copy of ``/var/run/dmesg.boot''. Then, make sure you include this file and the output of ``pciconf -lv'' in your report. Good luck, Giorgos -------------- next part -------------- A non-text attachment was scrubbed... Name: not available Type: application/pgp-signature Size: 187 bytes Desc: not available Url : http://lists.freebsd.org/pipermail/freebsd-questions/attachments/20070112/29114b8d/attachment.pgp


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Interested in becoming a local chapter president? Here is what you need to know.
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Volume 40, Issue 4
August 2019
Article ID 0028 August 2019
A near-infrared camera for iRobo-AO on the IUCAA 2-m telescope
The effect of atmospheric turbulence is gentler at infrared wavelengths than in visible regime. Hence adaptive optics (AO) delivers better performance in the infrared regime. Robotic Adaptive Optics (Robo-AO) is an AO system for medium-sized telescopes jointly built by Caltech, USA and IUCAA, India. It works with minimal overheads and provides good sky coverage in both visible and infrared regime. The first version of Robo-AO does not have a high-quality NIR camera. For the second version called iRobo-AO, an NIR camera was developed at IUCAA to accommodate AO-corrected 1.0$^{\prime}$ field-of-view in near-infrared bands. It can be used as a science camera as well as a tip-tilt camera. Here we describe the salient features of the NIR camera like optics, optomechanical design, detector control system etc.
Article ID 0029 August 2019
Temporal variations of the solar EUV network properties
The chromospheric network extended to the transition region as the solar EUV network disperses at the coronal level. The EUV emission lines from the transition region give information about different atmospheric heights. The network properties have been obtained from the daily spectroscopic data from theCoronal Diagnostic Spectrometer (CDS) on board the Solar and Heliospheric Observatory (SOHO) in two lines He I 584.5 Å and O v 630 Å. The synoptic changes in the line intensity, skewness of intensity distribution, meancontrast and network index with respect to the sunspot cycle were studied for a period of 11 years from 1996 to 2006. We have obtained the cross correlation of the monthly average of these quantities with the monthly sunspot number. The mean intensity and skewness of the two lines generally show a positive correlation with the sunspot cycle. The network contrast and network index of the He I shows a definite negative correlation with the sunspot cycle. The negative correlations shown by the He I line are unexpected which could be due toits anomalous behaviour. There are differences in the behaviour of the two lines regarding the time lag with the sunspot cycle and the magnitude of the correlation which is always higher for the He I line. The results haveimplications to the studies of solar irradiance, magnetic flux transfer and solar atmospheric dynamics.
Article ID 0030 August 2019
Rotational fatigue analysis on Shanghai 65-m fully-steerable antenna structure during its normal operation
Structural fatigue property of Shanghai 65-m fully-steerable antenna structure is analysed. According to the active fully-steerable working pattern, the typical fatigue stress piece is put forward based on simple sampling and decomposed by real-time rain flow counting algorithms. Subsequently, the fatigue lives of pitchmechanism bearings were computed by miner linear accumulative damage criterion. What's more, in a complete cycle of dynamic observation, the shear force and axial force of high strength friction grip bolts for all of the supporting nodes are extracted and counted aiming at each pitching angle. As a result, fatigue analysis is carried out on the supporting nodes of the back-frame structure connected with the pitching mechanism. Last but notthe least, finite element refinement model is conducted for the contact part between antenna wheels and the rail. Based on contact fatigue curve spectrum, the contact fatigue existing between the antenna structure roller andthe track is analysed. The results show that the fatigue life of the whole antenna structure can meet the safety requirements in the design reference period which is intended to be 30 years. This systematic fatigue analysis procedure, method and results can provide valuable references for design, construction and maintenance of such similar fully-steerable antenna structures in future.
Article ID 0031 August 2019
Dynamics of tilted Bianchi type-III cosmological model in $f (R, T)$ gravity
Tilted Bianchi type-III cosmological model filled with perfect fluid is investigated in $f (R, T)$ theory of gravity, where $R$ is the Ricci scalar and $T$ is the trace of stress energy momentum tensor. Here we study the class of $f (R, T) = R+2 f (T)$. To decipher the solutions of field equations, we used time power-law form of a metric potential $C$, i.e. $C = t^{m}$, where $m$ is a positive constant, which yields constant decelerationparameter. The solution of field equations represent an expanding model of the Universe. The physical behavior of the model are discussed by using some physical parameters.
Article ID 0032 August 2019
Quark novae: An alternative channel for the formation of isolated millisecond pulsars
Isolated millisecond pulsars (IMSPs) are a topic of academic contention. There are various models to explain their formation. We explore the formation of IMSP via quark novae (QN). During this formation process, low-mass X-ray binaries (LMXBs) are disrupted when the mass of the neutron star (NS) reaches1.8$M_{\odot}$. Using population synthesis, this work estimates that the galactic birthrate of QN-produced IMSPs lies between $\sim 9.5 \times 10^{−6}$ and $\sim 1.7 \times 10^{−4}$ yr$^{−1}$. The uncertainties shown in our experiment model is due to the QN's kick velocity. Furthermore, our findings not only show that QN-produced IMSPs are statistically more significant than those produced by mergers, but also that millisecond pulsar binaries with a high eccentricity may originate from LMXBs that have been involved in, yet not disrupted by, a QN.
Article ID 0033 August 2019
CCD $UBV(RI)_{\rm KC}$ photometry of NGC 2323 and NGC 2539 open clusters
The open clusters NGC 2323 and NGC 2539 have been analysed using CCD $UBV(RI)_{KC}$ photometric data, observed at the San Pedro Mártir Observatory. Cluster memberships have been determined with the proper motion and parallax measures from the GaiaDR2 astrometric data release. Photometric metal and heavy element abundances have been obtained as $([M/H], Z) = (−0.10, 0.012)$ (NGC 2323) and ($−$0.31, 0.007) (NGC 2539) from the $\delta (U–B)$ technique in the two-colour diagrams, which are used to select the appropriate PARSEC isochrones. The estimated reddening of NGC 2323 is $E(B − V) = 0.23 \pm 0.04$ using 11 early type stars. For NGC 2539, we find $E(B − V) = 0.02 \pm 0.06$. For $(B − V)$ colour, distance moduli and distances for NGC 2323 and NGC 2539 are derived as $(V_0 − M_V , d ({\rm pc})) = (10.00 \pm 0.10, 1000 \pm 50)$ and$(V_0 − M_V , d ({\rm pc})) = (10.00\pm 0.04, 1000\pm 20)$, respectively. The median GaiaDR2 distance $d = 1000\pm 140$ pc ($\varpi = 0.998\pm 0.136$ mas) for the likely members of NGC 2323 is in concordance with its four-colour photometric distances 910–1000 pc. For NGC 2539, its GaiaDR2 distance $d = 1330\pm 250$ pc ($\varpi = 0.751\pm 0.139$ mas) is close to its four-colour photometric distances, 1000 pc. Fitting the PARSEC isochrones to the colourmagnitude diagrams (CMDs) gives an old age, $890\pm 110$ Myr, for NGC 2539. Whereas NGC 2323 has an intermediate age, $200\pm 50$ Myr. One red clump/red giant candidate (BD-12 2380) in the CMDs of NGC 2539 has been confirmed as a member in terms of the distances $d_I = 950 \pm 50$ pc and $d_V = 910 \pm 90$ pc of $V I$ filters within the uncertainties, as compared to the distance $1000 \pm 20$ pc of NGC 2539. This giant's GaiaDR2 distance ($d = 1200 \pm 70$ pc) is not close to these photometric distances.
Article ID 0034 August 2019
Stability of gluonic systems with multiple soft interactions
In this paper,we investigate the stability properties of soft gluons in SIBYLL 2.1with reference to its original version 1.7 that corresponds to hadronic hard interactions. In order to investigate the stability structures, we classify the regions of the gluon density fluctuations in its double leading logarithmic approximation and its equivalent description as the fractional power law. In the parameter space of initial transverse momentum $Q$ and QCD renormalization scale $L$ that correspond to extensive air showers of cosmic rays, we have categorized the surface of parameters over which the proton is stable. We further discuss the nature of local and global correlations and stability properties where the concerning statistical basis yields a stable system or undergoes a geometric phase transition. Finally, we give a phenomenological understanding towards the stability of soft interactions, pomeron particle productions in mini-jet model, string fragmentation and verify our result corresponding to the experiments – CDF, P238, UAS, GEUS and UA4 collaborations.
Article ID 0035 August 2019
Tracing the outer disk of NGC 300: An ultraviolet view
We present an ultra-violet (UV) study of the galaxy NGC 300 using GALEX far-UV (FUV) and near-UV (NUV) observations. We studied the nature of UV emission in the galaxy and correlated it with optical, H I and mid-infrared (3.6 $\mu$m) wavelengths. Our study identified extended features in the outer disk, with the UV disk extending up to a radius of 12 kpc ($>2R_{25}$). We estimated the FUV and NUV disk scale-length as $3.05 \pm 0.27$ kpc and $2.66 \pm 0.20$ kpc respectively. The scale-length in FUV is 2.3 times larger than that at 3.6 $\mu$m, and we also find the disk to gradually become flatter from longer to shorter wavelengths. We performed a statistical source subtraction to eliminate the background contaminants and identified 261 unresolved UV sources between the radii 5.3 kpc and 10 kpc ($1 \sim 2R_{25}$). The identified UV sources show an age range between 1–300 Myr with a peak at 25 Myr and a mass range between 10$^{3} M_{\odot}$ to 10$^{6}M_{\odot}$, estimated using Starburst 99 models. The north-eastern spiral arm is found to be populated by young low mass sources suggesting that the star formation in this spiral arm is a recent phenomenon. The UV emission beyond the $R_{25}$ radius has contribution from these low mass sources and is extended up to $\sim 2R_{25}$ radius. We conclude that NGC 300 has an extended UV disk, mainly populated by young low mass sources. The star formation rate is measured to be $\sim 0.46 M_{\odot}$/yr which is comparable to its near optical twin M33.
Article ID 0036 August 2019
A revised catalogue of 294 Galactic supernova remnants
A revised catalogue of Galactic supernova remnants (SNRs) is presented, along with some simple statistics of their properties. Six new SNRs have been added to the catalogue since the previous published version from 2014, and six entries have been removed, as they have been identified as H II regions, leaving the number of entries in the catalogue at 294. Some simple statistics of the remnants in the catalogue, and the selection effects that apply, are discussed, along with some recently proposed Galactic SNR candidates.
Volume 41, 2020
All articles
Continuous Article Publishing mode
Since January 2016, the Journal of Astrophysics and Astronomy has moved to Continuous Article Publishing (CAP) mode. This means that each accepted article is being published immediately online with DOI and article citation ID with starting page number 1. Articles are also visible in Web of Science immediately. All these have helped shorten the publication time and have improved the visibility of the articles.
Click here for Editorial Note on CAP Mode


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A communication will be going out once date, venue and existing club committee members have confirmed their position in order to relay what roles are vacant.
All roles as are available if an individual wanted to put their name down and have it seconded on the nominations sheet which will be put up for 2 weeks on the club notice board and taken down 2 weeks before the meeting.
There currently or has never been any specific role and descriptions to pass on - some guidelines on EA below.
Only some recent roles/ tasks on club secretary and items Team leader/ Rob picked up. If you are interested then have a chat to the person in that position or someone in the committee.
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|Posted by elisabethneary on July 31, 2015 at 7:55 PM
Like many people around the globe this week, I was personally sad and angry to hear about an illegal poaching incident in Zimbabwe that took the life of a beloved (and monitored and protected) lion. I can't recall a time that worldwide furor and outrage have reached this level in recent months. Twitter was ablaze and even Jimmy Kimmel angrily weighed in during his https://www.youtube.com/watch?v=_LzXpE1mjqA" target="_blank">monologue. The incident struck a nerve. The level of emotion in national media coverage, online petitions and social media chatter on this topic is the highest I've seen it in years.
As a lifelong animal lover and environmentalist, I myself felt compelled to sign a few petitions and make my voice heard on social media. I certainly wasn't alone. Facebook and Twitter have been blowing up all week with people around the globe who are voicing outrage; many have included death threats. Though I certainly don't condone vigilantism, I do believe that the Web can and should serve as a global forum for people to voice their views in a civilized way, to be heard. And sometimes, as I hope will happen in this case, all this "noise" will make a real and lasting difference.
Which brings me to Yelp which, as you know is an online forum, founded in 2004 to "help people find great local businesses like dentists, hair stylists and mechanics." Yelp's homepage brags about the fact that they get 83 Million visits per quarter, and that the site boasts over 83 Million reviews. I myself routinely consult Yelp when choosing restaurants, and other service businesses and have posted a few reviews in the name of helping my fellow consumer-citizens make a more informed decision. Yelp also makes it clear that advertisers can never "change or re-order reviews." Regarding the illegal poaching incident, perpetrated by a dentist in Minneapolis, I posted my opinion on Yelp, as did so many others. It was a cacophony of outrage, and it felt like the very best of social media and freedom of speech.
So it was with great dismay and disgust that I and many others discovered that Yelp was practicing blatant and continuous censorship this week. Many thousands of people took to Yelp—their trusted go-to place to voice their opinion---to voice their anger and disgust about Walter James Palmer, the man named by the Zimbabwe government as the hunter who paid $55,000 to lure the famous lion out of the sanctuary and kill him for "sport." Throughout the week, members' reviews were deleted by Yelp employees. One estimate puts the number of reviews that Yelp deleted on this topic at over 20,000. Given that members kept reposting multiple times after being deleted, it could be many multiples of that number. Looking through the reviews, you'll see that many members doggedly kept reposting their reviews---five, six, seven times----defying Yelp's censorship and refusing to be silenced.
Yelp has built its brand as a place that consumers can go to hear fellow members' opinions. Its user-friendly interface enables people to post ratings and share their thoughts about businesses. This week, Yelp had a decision to make---honor the integrity of the social media forum and allow people to voice their opinions, OR use the heavy hand to squelch dialogue. In choosing the latter, Yelp has angered thousands of members on whom they depend for content, and seriously harmed their brand and reputation in the process. Yelp believes in free speech, but then, no-not-really-never-mind?
By repeatedly deleting thousands of members' reviews, Yelp made itself not only part of the news story, but the enemy of the members who trusted it to be a safe and trusted forum. Yelp's members rely on it to be a social media platform for an exchange of ideas and opinions---good or bad. By inappropriately inserting itself into the conversation, I believe Yelp has seriously disappointed a passionate chunk of its member base and done some serious damage to its brand.
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New Jersey is a great place to take in some FREE or low-cost family activities.
We love sharing with families fun things to do in NJ especially when it comes to events in New Jersey. If you are looking for things to do in New Jersey today or in the days ahead, just take a look at our Calendar of New Jersey events.
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Keyport Christmas Tree Lighting
November 30, 2019 @ 5:00 pm - 8:00 pmFree
All are invited to enjoy the annual lighting of our hometown holiday tree and welcome Santa and Mrs. Claus as they arrive by fire truck. Entertainment includes the Keyport Central School Chorus, a dynamic Master of Ceremonies, hot chocolate, a children's ornament work shop, candy canes and of course, a chance to sit with Santa and Mrs.Claus!
Santa's Workshop returns bigger than ever – located in Borough Hall, there will be over 600 ornaments for kids to decorate, to take home or place on the tree in the MiniPark. There will also be knock hockey and snow ball toss games.
Don't forget your camera!


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Boost :
From: Victor A. Wagner Jr. (vawjr_at_[hidden])
Date: 2005-11-02 21:17:29
At 17:08 2005-11-02, Bronek Kozicki wrote:
>Peter Dimov wrote:
> > Yes, this is well known; but the fact that VC8 as shipped fails a
> Boost test
> > may be unknown to them. It wasn't clear to me which of the two you had in
>yet another reason to ask them to run regression tests before support
>for vc8 goes official
has the problem been fixed? the results from metacomm show that my
run at 2005/11/02T2200 has no failures in bind.
>Unsubscribe & other changes: http://lists.boost.org/mailman/listinfo.cgi/boost
Victor A. Wagner Jr. http://rudbek.com
The five most dangerous words in the English language:
"There oughta be a law"
Boost list run by bdawes at acm.org, gregod at cs.rpi.edu, cpdaniel at pacbell.net, john at johnmaddock.co.uk


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RAWR is Hello in Dinosaur
RAWR is hello in dinosaur – Cut File
RAWR is hello in dinosaur and little boys and girls know it well. With this funny, childish cut file about dinosaurs, all the kids will feel like playing and learning at the same time. Custom t-shirts, saying pillows, wall tattoos and much more will look great when decorated with this word art print for children. Make custom crafts for kids and encourage them to explore this fascinating world of dinosaurs – you can never tell where your child's passion for science will pop up from.
You will receive this design in the following formats:
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This conversation is no longer open for comments or replies and is no longer visible to community members. The community moderator provided the following reason for archiving: Archiving inactive content
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text: Nick Kozak (b. 1982) is a freelance photojournalist whose current work is focused on the issues of community and identity, their inseparability and constant state of flux. He explores communities that are displaced, marginalized, and/or those carving out new social spaces out of necessity or a desire to redefine a collective identity. His curiosity is combined with a keen eye, innate sensitivity and desire for greater social awareness.


text: Guest Farmboyzim Posted February 5, 2007 Just a note of thanks to those of you at AVSIM regarding your interest in Hop Races by placing a poll regarding the fact on your site, and quickly at that I might add! No sooner did I notify you of the news of monthly Hop Races for payware prizes over at my site, www.farmboyzimsflightsims.com on the first of February, when faster than a speeding Learjet, the poll was posted the following day! Again thanks for the interest, and more information on the Races can be found at,http://www.farmboyzimsflightsims.com/FEB07_Race.htmlBy the way, the races are FREE and FUN!!!Thanks again!Farmboyzimwww.farmboyzimsflightsims.com Share this post Link to post Share on other sites


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Enloe meets your urgent medical care needs with two Prompt Care Clinics in Chico, Calif.
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Periodontal disease is a serious bacterial infection. It destroys the gums and supporting structures of the teeth. It is also called gum disease.
The buildup of plaque on the teeth is the main cause of periodontal disease. Plaque contains bacteria that sticks to the teeth. If plaque isn't removed, it hardens and is then called calculus or tartar. Poor oral hygiene habits allow plaque to grow in the mouth.
Certain things may raise your child's risk for periodontal disease. These include:
Certain genes
Food stuck in the gums
Mouth breathing, which may lead to severe drying of the gums and teeth in the front of the mouth
Poor diet
Smoking and using smokeless tobacco
Autoimmune or systemic diseases
Hormonal changes in the body, such as during puberty
Repeated clenching or grinding of the teeth that your child can't control (bruxism)
Certain medicines that can cause an overgrowth of the gums
Periodontal disease can range from mild to severe. Most children with gum disease have the mildest form, called gingivitis. It causes the gums to become red, swollen, and sore. More advanced cases of gum disease are not common in children.
Generally, gum disease isn't painful. So your child may not know if he or she has it. Below are the most common symptoms of gum disease:
Red, swollen, sore gums
Bleeding while brushing or flossing
Gums that pull away from the teeth (receding gums)
Loose or separating teeth that show greater than normal spacing
Bad breath that won't go away
Pus between the teeth and gums
A change in bite and jaw alignment
These symptoms may seem like other health problems. Have your child sees his or her healthcare provider or dentist for a diagnosis.
Your child's healthcare provider will likely refer your child to a dentist for evaluation and care. Your child's dentist can often diagnose periodontal disease with a complete history and exam of your child's teeth and gums. Your child may also need X-rays.
Your child's dentist may refer your child to a periodontist. This is a dentist with special training to treat periodontal disease.
Treatment will depend on your child's symptoms, age, and general health. It will also depend on how severe the condition is.
Early treatment is important. It can prevent the gum disease from getting worse. If the disease is left untreated, underlying bone around the teeth may dissolve. It will no longer be able to hold the teeth in place.
Treatment may include any or a combination of the following:
Good dental care. Regular cleanings by a dentist can help fight gingivitis, the mildest form of gum disease. Your child will also need to brush and floss daily.
Deep cleaning (scaling and root planing). This treatment can help remove the plaque and tartar under the gum and infected tissue in the early stages of the disease. It can also smooth the damaged root surfaces of the teeth. The gums can then reattach to the teeth.
Medicine. Antibiotic medicine may be put in the periodontal pockets. Or it may be given in pill form to take by mouth.
Surgery. When gum disease is advanced, the infected areas under the gums need to be cleaned. The tissues may also be reshaped or replaced.
Good dental habits can prevent gum disease. Make sure your child:
Brushes his or her teeth twice a day
Uses a toothbrush that is the right size based on your child's age and size
Flosses daily
Sees the dentist regularly
Eats healthy foods, limiting those high in sugar and starch
Periodontal disease is a serious bacterial infection that destroys the gums and supporting structures of the teeth.
It is also called gum disease.
The main cause is plaque buildup on the teeth.
Children are more likely to have gingivitis, the mildest form of the disease.
Symptoms include red, swollen, sore gums. The gums may also bleed when brushed or flossed.
Good dental care can help prevent gum disease.
Tips to help you get the most from a visit to your child's healthcare provider:
Know the reason for the visit and what you want to happen.
Before your visit, write down questions you want answered.
At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you for your child.
Know why a new medicine or treatment is prescribed and how it will help your child. Also know what the side effects are.
Ask if your child's condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if your child does not take the medicine or have the test or procedure.
If your child has a follow-up appointment, write down the date, time, and purpose for that visit.
Know how you can contact your child's provider after office hours. This is important if your child becomes ill and you have questions or need advice.
Get the latest news and updates delivered to your inbox.
Enloe Medical Center. All Rights Reserved.


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A small hall down a dead end street, a chapel of ease to St Mary, Becontree.
Architects & Places
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- A Church Near You (CofE)
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Goat IgG F(ab')2, PE, Isotype Control, Invitrogen
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The isotype of a primary antibody and the application it is being used in can result in background staining. Primary antibody background noise can be caused by binding to Fc receptors on target cells; by non-specific interactions with cellular proteins, carbohydrates, and lipids; or by cell autofluorescence. Isotype control antibodies can act as negative controls to help differentiate non-specific background signal from specific antibody signal because they have no relevant specificity to a target antigen. While isotype controls are most commonly used in flow cytometry, they are useful in other applications such as chromatin immunoprecipitation (ChIP), immunohistochemistry, and gel shifts. Isotype controls should match with the primary antibody species and isotype so that the level of specific staining by the primary antibody may be accurately determined. If using directly labeled primary antibodies, the isotype control works best if conjugated with the same label as the test antibody.
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Sign up with your neighbors to save WASTED coins for a compost-bin in your neighborhood!
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In the beautiful spacious children's clothing store Broer & Zus you can go with your child for the best children's clothing; shirts with original prints, warm sweaters, and dresses made of beautiful and soft organic fabrics. Children can frolic, jump and play outside. We think it is important that children's clothing is sustainable, which means to us timeless, responsible and long-lasting. This way, several children have fun from the same clothes.
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FurnitureBarbeque Grills & SuppliesRetail
Monday-Friday 9:00 AM - 5:30 PM
Saturday 9:00 AM - 2:00 PM
Sunday CLOSED
Established in Sept. of 2003, Sander Furniture Co. has become a very progressive and competitive business that has a leading line of products! Nestled in the center of the U.S. in the Kansas town of Norton, we have ''Old Fashioned'' service and values that let us better serve our valuable customers.
With Name Brand Furniture , Mattresses, Appliances, Carpet and Home Accents Sander Furniture Co. can offer great home living options along with great home service!
Sept. 2017: TRAVELING KANSAS is a local production from Smoky Hills Public Television that highlights communities, people and attractions across the state. This episode explores the past and present with a spotlight on the restoration of several historic buildings in Norton and the economic development efforts throughout the county.
Norton County Arts Council Updates! Click Here...
NORTON COUNTY MAGAZINE (Est. 2011) Covering the people, life, history and commerce of Norton County! The Magazine is published quarterly. Thanks to great sponsors, the Norton County Magazine is free to Norton County residents in zip codes 67622, 67645, 67653 and 67654 as well as nearby community 67647. If you live in these zip code areas and are not receiving your issue, let us know. To subscribe, send your name, mailing address and email address to Norton County Magazine, PO Box 163, Norton, KS 67654 with your check made payable to Frontier Community Foundation. The rate is $24 per year for 4 issues. Carolyn Applegate, Editor. Contact Information: (785) 877-3968
Click here for the latest issue of the LENORA MERIDIAN
17th Annual Norton Chamber Car Show DETAILS HERE
Norton County Community Foundation Awards $6,788 in June Grant Cycle PRESS RELEASE
Norton County Community Foundation Awards $16,200 in Scholarships PRESS RELEASE
Nex-Tech Update of its Continuous Learning Initiative. PRESS RELEASE
Norton County Community Foundation Awards $12,500 in April through the Emergency Grant Funding Program PRESS RELEASE
Norton Christian Church Launches Volunteer Delivery Program SEE PRESS RELEASE
Norton County Community Foundation Launches Emergency Grant Funding Program In Response to COVID-19 PRESS RELEASE HERE


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