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There is a reason why I haven't been able to work on my blog or shop as I used to. And that is simply because of my health. I always tried to avoid talking about this topic because I'm still learning to deal with this myself and searching for answers but why do I have to wait till I can handle the situation? Why not just open up about it now?
That's one of the reasons why I started blogging about my health: to help others who are going through the same. To be a voice for those who cannot talk about this. And writing has become some kind of therapy for me. A place where I can honestly talk about subjects that I have a passion for but also about issues I'm struggling with.
Late Spring, beginning of Summer I started experiencing new symptoms. The first time I woke up in the middle of the night all sweaty and shaky. I had no idea what was going on. I first thought it was just a nightmare so I decided to get up. I couldn't. I felt drawn to the ground and my heart started pounding really fast. It felt like there was sweat dropping off my whole body but it didn't. Totally freaked out I called for my mom who luckily was there to help me get through it. She wetted a towel and put it on my legs, opened the window, put the fan on and gave me some salty chips and water. It faded away after a while but the next day I felt extremely exhausted. Most people would think this was due to dehydration but I drink plenty of water. What was going on?
This happened again a few times. Not only at night but it could happen any time as I was sitting, standing or laying down. As a chronic illness patient it's hard to know when something is a flare from your illness or when it is caused by something else. I've fainted in the past and I struggled with dizziness multiple times before but never to this extent. And most of the times I could prevent it from happening. I never felt so dizzy out of the blue, it usually happened when I overdid things or pushed my body too far. I needed to see a doctor.
My blood got checked: my vitamin B12 and iron levels were frightening low. Another thing that got tested was the active standing test. If you don't know what that is, it's basically getting your blood pressure and heart rate measured when you immediately stand up after laying down a few times. It showed how my blood pressure would drop low after a few seconds and my heart starts beating faster to compensate.
My doctor diagnosed me with orthostatic hypotension (a form of dysautonomia) that is caused by my other chronic illnesses: myalgic encephalomyelitis and fibromyalgia. Please considerate the same illness may affect people differently or the same symptoms may be caused by different illnesses.
After about six injections of vitamin B12 and two of iron combined with homeopathic oil for low blood pressure I noticed a difference. I got another attack after a physical activity but it didn't happen anymore while sitting or laying down. While I'm writing this I'm going to my doctor later today to get my blood checked to see if my body is taking up the vitamins. I still have a ton of questions that I hope to be answered.
The thing that scares me the most is, when this happens at public places. On my way to visit a friend I threw up because of dizziness in a packed train. Last weekend in Brussels the dizziness and nausea hit me again but I luckily got home in time. It worries me and those around me.
You would think I'm getting used to health problems now right? But the thing is, just when I thought I found ways to manage life with chronic illness, new things come up. I feel like I have to go through everything all over again and it sucks. It makes me insecure about the future and I hate losing that little control I had.
Right now I'm still searching for answers and finding ways to live a 'functional' life with these new symptoms. I've been adjusting by eating more salty, but small portions, getting more hydration and making sure I cool down. Heat really affects my symptoms. I bought a mini hand fan that I can always bring with me and I use my ice pack almost daily.
I'm more than happy if one person out there reads this and feels less alone in their fight.
Lots of love,
#chronicillness #dysautonomia #orthostatichypotension #fibromyalgia #chronicfatigue #ME #chronicpain #invisibleillness


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For my TOH column at Indiewire, I discuss the Oscar-nominated makeup for Harry Potter and the Deathly Hallows — Part 2, The Iron Lady, and Albert Nobbs with Nick Dudman, Mark Coulier, and Matthew Mungle.
"The thing about 'Potter' we've always said is: You've got to treat it as though it isn't a fantasy film at all — you've got to treat it like everyone's got a history they've lived through and it has a reality to it. So we really did obsess on detail," Dudman says.
"We thought that with the wig and the costume and Meryl's performance, that was enough for the younger age. For the older, we pushed it a little further: we injected more of the puffy cheeks that Thatcher developed in later years and the neck," Coulier recalls.
"It was all about taking these two beautiful women and turning them into men," explains Mungle.


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The cases of gold smuggling through Jaipur Airport have become frequent. In a fresh incident, a case of gold weighing 620 gms has been revealed on Monday when the customs found a man carrying gold in his jeans and in rectum. Sources informed that Imran, the accused passenger had come to Jaipur on Monday morning from Bangkok . The value of the gold confiscated from the accused passenger is said to be around Rs. 27 lakhs. He is being interrogated by the officials of customs department.
Very recently, in the month of February itself, smuggled gold weighing 1.066 kg and worth Rs 44.96 lakh was seized at Jaipur Airport here from two suspected passengers, who hid the yellow metal in their rectum. These accused were coming from Bangkok and Dubai.
Earlier in the month of January, a national of a Far East country was arrested for smuggling kg gold worth Rs 2 crore while two people were arrested in the same month who were trying to smuggle 466 gms of gold while coming from a flight from Dubai to Jaipur.
While smuggling the yellow metal from gulf nations was observed commonly, the cases of smuggling of gold from Bangkok has seen a spurt in last few months.


text: Andrew is currently vice president and head of Collaborations in Data & Computational Sciences ast GSK. Andrew trained as a statistician at the University of Oxford although he has spent most of his career to date working as an epidemiologist. He started his professional career in infectious disease epidemiology, before spending a significant amount of time in oncology working at Cancer Research UK's Epidemisology Unit in Oxford. He moved to industry in 2009 and held various roles first at Amgen and then latterly at GSK where he was most recently Global Head of Epidemiology and RWE. Andrew is an internationally renowned expert in epidemiological research and the intersection with health informatics leading to his interest in utilising routine data for research purposes. Andrew participates on several expert advisory boards where his expertise in epidemiological methods and health informatics are highly regarded.


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Saturday, April 9, 2011
Right time, right angle
Labels: Pictures
3 comments:
- OrbsCorbs said...
Those are great. The one with the little silhouette hanging from the walk signal is kinda tragic.
- April 9, 2011 at 10:29 PM
- drewzepmeister said...
I like the forth one down. Reminds me a kai blast scene from a Dragonball Z cartoon.
- April 9, 2011 at 11:28 PM
- lizardmom said...
those are really funny, love the scrunched up nose cleaning LOL!
- April 10, 2011 at 8:11 AM
Subscribe to: Post Comments (Atom)


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Charles Dickens - 9781486435210
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Charles Dickens' life was a tale of rags to riches, becoming one of the most well known and most read writers to this day, with his books never gone out of print. Dive into this duo of Dickens books, Great Expectations and A Tale of Two Cities, two of his most popular sold books!
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Beginning and ending with some of English literature's most famous lines, Charles Dickens' A Tale of Two Cities thrives on tension and conflict between Charles Darnay and Sydney Carton who fight for Doctor Manette's beautiful and kind daughter Lucie Mannette. From the tranquil streets of London, they are found against their will in the treacherous streets of Paris at the height of the Reign of Terror, the bloody backdrop of the French Revolution.
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text:
Background to the programme
The Department of Solidarity Procurement (CMS) was born in 2012 when the associations Streets of Sustainable Development (RDD), Culture and Cooperation (C & C) and Inter Network Integration through Economic Activity (IRIAE) formed a solidarity group and collectively responded to a call for projects which was launched as part of the Social and Solidarity Economy Cooperation Programme (PROCESS) framework. Since 2010, these associations have participated in the ESS impact assessment study in South Loire which was conducted by the Mife South Loire and also in the establishment of the ESS strategic development plan in South Loire: PROCESS 2012-2015 .
Objectives of the programme
=> Strengthen the expertise and independence of ESS actors through the implementation of a complete support service.
=> Encourage connections between ESS organisations, public authorities and traditional businesses in the area to promote socially responsible business.
Implemented actions
The launch in 2013 of the first support system for ESS structures in South Loire to response to public and private procurement. The main services offered to organisations are:
• a qualitative assessment of calls for public and private procurement contracts that are likely to interest them,
• a service for information, training and networking for structures from Social and Solidarity Economy to promote cooperation and group responses
• individual or collective support service in response to procurement.
Quantitative and qualitative results from the implemented actions
During these first two years, we have been able to demonstrate the interest of CMS in:
- Promoting and encouraging group responses and synergy between economic actors;
- Develop an approach within ESS which is collaborative rather than competitive;
- Improve the clarity and relevance of ESS organisations in the eyes of purchasers.
The 2013 assessment in a few figures:
- 41 organizations met for a first analysis.
- 5 organisations supported in procurements that were targeted by CMS including 1 contract won by the association.
Original characteristics
The project's originality lies both in the assembly and formation of a solidarity group and in changing the organisation and operation of the parties involved. This new organisation gives priority to cooperation, participation and the pooling of resources for the benefit of local, sustainable development in South Loire territory. During the first year of experiments (2013), CMS created and developed a scalable tool that is capable of adapting to changes that encourage the promotion of socially responsible business.
Partnership(s) developed in the context of the programme
The project is part of a cooperative approach. The added value lies in the search for real consistency and synergy through the development of local and regional partnerships. Main partners: C & C - IRIAE - Saint Etienne Métropole - Rhône Alpes - The Centre for Information, Training and Employment - The Scop La Peniche - CRESS - The Centre for Employment and Training.
Difficulties and/or obstacles encountered during the programme's implementation :
At the beginning of the action, most of the structures encountered were reluctant or even hostile to this new way of financing. CMS worked in a thorough manner to promote a participatory approach, in which each of the services proposed was adjusted to the needs and expectations of the actors.
Solutions used to overcome the difficulties and/or obstacles :
CMS chose to offer free services in order to not add additional impediments to remote organisations under public or private control. Instead of compartmentalising the organisation, CMS opens its services to actors outside of ESS such as freelancers, the self-employed and micro-businesses. The only requirement is that their approach falls within the principles of ESS (social purpose, limited profit, democratic governance ...)
Suggestions for future improvement :
In the years 2014-2016, CMS aims to develop the support and the procurements that have been won. The services offered will expand to include unpublished public procurement (below the thresholds) and private procurement from businesses in the Loire.
Summary of factors responsible for the programme's success :
The project is replicable in other local authorities who choose to promote socially responsible public procurement through local networks of ESS offices.
Key factors for its success:
- Strong political will to make ESS a policy priority.
- The network dynamic and synergy between the members on the project team.
- A permanent team and a resources team who are competent, qualified and capable of responding quickly to all types of request whatever the field of activity.
- A good knowledge of local networks in the territory and through ESS.
- Responsiveness and availability of the project team.
- The flexibility of local actors and meetings between them.


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The South African government has recently passed a law that allows communities to actively hunt over 30 species of wild animals, birds, and even reptiles. These include: Rhino; elephant and other endangered species, as well as snakes; mongoose (the African version of the weasel); and - wait for it - even bats! Not only for the sake of those species that are already on the brink of extinction, but for the health of the people in South Africa, this legislation needs to be stopped before it results in even more deaths!
For those who want to find out more, here is the link to the original article:https://mail.google.com/mail/u/0/?tab=rm&ogbl#inbox/FMfcgxwHNVzMTqkpmWXZmZgJrhnxzpML
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First-time team members understand why Dr. Joe Stasko of Windsor, Ontario, continues to travel to Nicaragua. It goes well beyond the number of abscessed teeth, the necessary cleanings, scalings and fluoride treatments that the team tackled. It lands with the personal interactions that occurred, and the true difference that the work that they do made.
Two 35-year-old twin brothers arrived at the Skylark Centre for the dental clinic in February. One of the two was not flashing a smile upon greeting the team. He presented with an abscess in the back of his mouth, but the condition of his front teeth were a (and, his primary) concern. Following treatment, his reaction was thrilling. His goal in attending the clinic attended by the visiting dental team was to get his smile back. He expressed thanks to the Good Lord for his sending of this team who was able to do just that!
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In November of last year, California voters passed Proposition 47, the "Safe Neighborhoods and Schools Act."
The New Conditions
(1) Prop 47 changes some California crimes from felonies to misdemeanors.
These crimes include:
- Grand theft auto and grand theft firearm, only if the car or gun that is stolen is worth $950 or less;
- Check fraud, only if the bad check(s) are for $950 or less;
- Receiving stolen property, only if the property is worth $950 or less; and
- Simple possession of a controlled substance (assuming no enhancements)
(2) Prop 47 gets rid of the concept of petty theft with a prior.
(3) Prop 47 would make most minor instances of commercial burglary a misdemeanor count of petty theft, even where there was intent to steal before entering the store.
(4) Prop 47 does not apply if you have certain violent felonies or sex crimes on your record.
(5) Prop 47 allows you to apply for resentencing if your sentence is affected by the new law.
If you are currently serving OR have completed a felony sentence for any of the crimes listed above, you can apply to have your conviction reduced to a misdemeanor–and your sentence reduced accordingly. For assistance, please call our office today.


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On Very Visceral Mysteries: 'The Woman in Cabin 10'
Much of what happens to the protagonists here and in the comparable The Girl on the Train evades their control.
The Woman in Cabin 10Publisher: Simon and Schuster
Author: Ruth Ware
Price: $26.00
Format: Hardcover
Length: 340 pages
Author website: www.ruthware.com
Publication date: 2016-07
In a much quoted tagline, Ruth Ware's second novel, The Woman in Cabin 10 (2016), has been described by Stylist as "a rollicking page turner that reads like Agatha Christie got together with Paula Hawkins to crowdsource a really fun thriller." At first, this tagline appealed to me: I've been a fan of Agatha Christie since forever, and I loved Paula Hawkins' 2015 mystery, The Girl on the Train. The further I got through the story, though, the more doubt seeped in about whether there could actually be such an unnatural creature as a cross between Paula Hawkins and Agatha Christie. The Woman in Cabin 10 illustrates why, in fact, there can't be.
This comes on the heels of her successful debut novel, In a Dark, Dark Wood (2015). Both novels are what she calls on her website "psychological crime thrillers". Both feature flawed heroines who are swept up in crime in the course of their very typical lives (at a hen party, on the job); and while neither protagonist is a Hercule Poirot or a Jane Marple, they manage to stumble to some sort of resolution of the murders that embroil them, although they are always victims as well as would-be amateur (and rather unwilling) detectives.
Travel writer Lo Blacklock is sent to cover a cruise for the magazine where she works. (The senior writer who usually covers such choice assignments is on maternity leave.) Before her trip, though, Lo wakes up in the middle of the night to find an intruder in her apartment. While the intruder merely slams the bedroom door in her face, Lo is deeply traumatized, and her experience haunts her as her luxury cruise begins. Before the ship is long underway, Lo sees a mysterious woman in Cabin 10 -- a woman who subsequently disappears and whom no one will admit to ever having seen. Lo also hears what she is convinced is a body falling overboard one night. Yet none of the passengers is missing. The novel follows the unraveling of these mysteries, with the hapless Lo at the center.
The Woman in Cabin 10, as I mentioned above, bears much resemblance to Paula Hawkins' The Girl on the Train, and virtually none to the mysteries of Agatha Christie, although the bare outline of the plot suggests Murder on the Orient Express (1934). The Girl on the Train even more clearly evokes 4:50 From Paddington (1957). I think exploring why these contemporary novels are not like Agatha Christie's novels usefully illuminates what is becoming a veritable subgenre in the world of crime fiction.
Christie's fiction, for the most part, has a stable, almost uncannily omniscient detective figure -- a reliable center of knowledge. Both Ware's and Hawkins's novels, on the other hand, are narrated by characters who are unstable and profoundly unreliable. Rachel, the protagonist of Hawkins's novel, suffers from a serious drinking problem and routinely experiences blackouts; these blackouts form holes in her memory, in her very sense of self, which she struggles to overcome as she tries to figure out what happened to a woman who has vanished from the street where she used to live.
Ware's Lo has some similar issues with drinking; she takes medication for anxiety; and she is suffering from PTSD after her home invasion -- all of which lead the cruise ship's detective, among others, to discount her protestations about both the missing woman and the sound of a body going overboard. They also lead Lo to doubt herself, and she has to work to prove to others and to herself that she is, as she says (defensively), "in charge". Christie's detective characters never have to try.
While The Woman in Cabin 10 hints at Christie's The Murder on the Orient Express in that both novels take place in a strictly circumscribed space, with a list of suspects limited to those on board, the differences are telling. Hercule Poirot thoroughly masters his space and his cast of suspects; he grasps immediately where each train compartment is in relation to the others and who occupies it. There's a crucial moment, on the other hand, when Lo escapes from where she's been confined on the (relatively small) ship, and, even though she's re-tracing steps she took earlier, she takes a wrong turn, stumbles around, gets utterly lost.
Her spatial disorientation marks her existential and epistemological "lostness": Lo rarely realizes where she is or what things around her mean -- and much of what happens to her is accidental, not the effect of her conscious design. The creation of this kind of unreliable narrator in a crime novel, like Rachel in The Girl on the Train, is a great strategy: it adds an additional layer of mystery to the plot; readers have to figure out not only the external events of the story, but they must also navigate the protagonist's own murky mental and emotional terrain.
My only problem with how Ware executes this narrative strategy in both The Woman in Cabin 10 and The Dark, Dark Wood is that I was able to see quite clearly what was going on before the narrator did, and I tend to be a distinctly uncritical reader of crime fiction. (I never saw the endings of any of Christie's novels coming, or that of The Girl on the Train, for that matter.) Ware makes the solutions of her mysteries a bit too obvious, (for the reader, if not for her protagonist), and her novels would be more effective if her clues were less glaring.
What I love about The Woman in Cabin 10, though, as well as The Girl on the Train, is the thoroughly embodied nature of the heroine, which speaks to the equally embodied nature of knowledge itself. We know things with and through our bodies: Ware's Lo, like Hawkins's Rachel, suffers bodily trauma, experiences irrational bodily disorders (like panic attacks), undergoes struggles with addiction, and experiences things like fear, desire, rejection, and depression in a very bodily way. Everything that happens to these heroines' bodies shapes the way they think -- and indeed, whether they can think at all.
This complex view of what is our embodied ways of knowing is very far from the transcendent selfhood of Hercule Poirot (influenced, of course, by Doyle's Sherlock Holmes and Poe's Auguste Dupin). Near the end of Murder on the Orient Express, Poirot declares that from now on "it is all here", as he taps himself on the forehead. He then sits utterly still, eyes closed, and thinks, and thus he solves the crime. This is the end of an investigative process that has involved Poirot's body not at all: he has asked questions, he has talked, he has thought. Christie's mysteries are cerebral puzzles. Which of us actually lives or knows like that?
The Woman in Cabin 10, like The Girl on the Train, features not only a fallible protagonist, but a protagonist who thinks and knows and lives in and through her body. Much of what happens to both protagonists, as a result, evades their control, exists as dark holes in their flesh that they have to think around. As Hawkins puts it in The Girl on the Train, "the holes in your life are permanent. You have to grow around them, like tree roots around concrete." The Woman in Cabin 10 and The Girl on the Train show us that those holes are bodily and that you inevitably have to know and seek truth, as well as "grow" around them.
There's no rapprochement, then, between Ruth Ware, Paula Hawkins, and Agatha Christie. They represent fundamentally different ways of being and knowing, fundamentally different ways of telling a story.


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It all went smoothly and there was no pain
I would recommend Praga Medica Eye Surgery Clinic to everyone, including my own family. When I could no longer wear contacts, my daily life was ruled by wearing reading glasses, then distance glasses. I kept losing them too!
I chose Praga Medica after thorough research into procedures and clinics and some helpful advice from my own ophthalmologist in Scotland. In October 2016 I had laser surgery for Astigmatism along with Femtosecond laser assisted cataract surgery (femto-cataract) for both near and distance sight correction. I did not have cataracts but this uses the same procedure before the eye surgeon implants new artificial tri-focal lenses.I am overjoyed with the results. It was definitely good value- at least 70% cheaper than the procedure costs in a top hospital in Scotland (and they only offered a mono-lens (single).
Praga Medica Healthcare arranged for an interpreter (Rita) to accompany me. Thank you Monika too and John who drove me from and to the airport. You all helped make this trip run as smoothly as possible.On day one, the extensive pre-surgery check-up increased my confidence in choosing this clinic. Each staff member was cheerful and respectful and efficient. The reception area was clean and comfortable and there was a minimal waiting time. On the two procedure days (one for each eye) the staff were consistently supportive.It all went smoothly and there was no pain. It was comforting to have an eye check-up the day after each surgery too- again increasing my confidence in this wonderful clinic.
I've suffered with poor vision for over forty years with a bad lazy eye and astigmatism and sick of wearing thick glasses, then onto contact lenses, i
decided enough was enough.
I Started looking around on the internet after hearing about interoculor lens replacement surgery, I came across Pragamedica and Duovize which is the same
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The doctors carried out extensive tests on my eyes with numerous equipment which took around three hours, to decide what was the best option for my eyes and
suggested tri focal inter ocular lens replacement surgery . Which will let me see near and intermediate and distance.
The surgeon Dr Lubomir Tovarek who carried out my operation was excellent he made me feel very relaxed all through the surgery.
The bit i must express is that while you are waiting to go into the operating room, you are in a little room been prepared for the surgery with about two or
three other people all waiting for there turn and every ten minutes or so a nurse comes round everyone with local anaesthetic eye drops to numb the eye which is
been operated on,
I can assure you the operation is painless you do not feel a thing the surgeon Dr Lubomir Tovarek is so gentle he was fantastic, i cant express my
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Because i had very poor vision in my right eye which was my lazy eye the doctors wanted to operate on this eye first, the next morning when i took the patch off
i was so overwhelmed with the result i could see perfect for the first, in my life i couldn't wait to have my other eye operated on, and after the surgery
on my left eye, next morning i was worried with my eyes been so bad with my lazy eye, as to the result to expect, i was so worried, i fell asleep that night
with my patch covering my left eye, I woke up at about 04.30 in the middle of the morning and my patch had fallen off.
I went to look out of my hotel window to see what i could see i was on the sixth floor and Prague city in darkness only street lights and shops and hotels..
I could not believe how good i could see it was an amazing experience i got dressed straight away and went for a walk through Prague to take in what i could
My vision was so crystal clear it was the best day of my life, i cant thank everyone enough,, at pragmedica and Duovize they have changed my life forever..
Don,t Hesitate if you are thinking about having this surgery, go to Prague i found the doctors more professional than the opticians in England my experience in
England it was all about the money and not the patient
and i costs half the price and the doctors and staff at pragmedica and DuoVize was excellent they treat everyone with so much care and professionalism they take
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Over all this is the best place to come for your eye treatment
Am 64 year old My treatment was natuarl lens replacement, of which i would recommend to anyone. It took approximately 1 week from medical exam to youre last eyes test .The surgery last around 8 minute, which is absolutely painless, doctor and nurses very professional, and look after you So well,i cant praise them any higher, certainly recommend Praga Clinic to anyone its approximately 6 week since my treatment, my eyes sight is perfect i can read all the small print in the newspaper, kind regards john
Praga Clinic do a package deal being packed up from the airport and back again, i would advise this deal to anyone, also on the first day you are met by one of the rep, Helena was my guide she was a lovely lady with perfect English, she could not do enough for you.The Clinic was very clean, with water,and coffee available. All the stuff at the clinic speak perfect English,, Over all this is the best place to come for youre eyes treatment. With out a dought, regards john
I am pleased to say it was 100% success
I was blind but now I see! I under took Intra Lasik Laser Eye Surgery on the 30 July 2016. I am pleased to say it was 100% success. I have worn glasses/contact lens for 22 years and it is a fantastic change to finally be able to see without them.
Praga Medica are excellent value for money. Considering the prices in the UK, you pay less then half the cost in the UK. There is no compromise in quality and only the latest modern machines are used.
As results my vision is perfect and my only regret is why I did not do this sooner!
Overall a very positive experience and am grateful to everyone at the Praga Medica for making my experience a one to remember.
I would use them again for any other operations and would recommend them!
Many thanks,
Coulsdon, England
am very thankful to prague medica.
i had a trauma cataract in my one eye.i tried various eyedrops without success.i decided on cataract surgery.i wanted laser catact surgery with the new tri focal lens but only Harley st did this at the cost of 7000 pounds.after much research I went to prague medica in prague and had the laser surgery with tri focal lens for about 1500 pounds.it was a total success.
I chose this clinic after much research. they use the same laser machine and tri focal lens as harley st, and the surgeon has much experience. they picked me up at the airport and found a nice hotel for me. the surgery took about 10 minutes and i felt nothing. next day i took off eye patch and found i had perfect vision. it was one of the happiest experiences of my life and am very thankful to prague medica.


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Heidelberg, Hinxton, 8 July 2020 Two EMBL scientists become EMBO Members This year, EMBO elected 63 new members, including Alexander Aulehla, Group Leader and Senior Scientist at EMBL Heidelberg, and Paul Flicek, Associate Director of EMBL-EBI Services, Senior Scientist, Group and Team Leader at EMBL-EBI. more
Grenoble, 8 July 2020 ALPX – smart crystallography ALPX has become the latest spinoff company from EMBL Grenoble. It offers fully automated and remote-controlled protein-to-structure pipelines for protein crystallography and fragment and compound screening. The ALPX high-throughput services enable researchers to solve crystal structures faster, thus accelerating research in a range of fields from pharma to biotech. more
Heidelberg, 8 July 2020 What COVID-19 is teaching us The virtual EMBL Conference 'SARS-CoV-2: Towards a New Era in Infection Research' explored the importance of fundamental research, collaboration, and data science in containing the SARS-CoV-2 pandemic, and discussed opportunities to improve our response to pandemics in the future. more
Heidelberg, 6 July 2020 Edith Heard elected senator of the Max Planck Society EMBL Director General Edith Heard has been elected a senator of the Max Planck Society, one of Germany's leading scientific research organisations. She joins the Senate along with Nobel Laureates and EMBL alumni Christiane Nüsslein-Volhard and Stefan W. Hell, as well as nine additional new senators. more
Heidelberg, 3 July 2020 From stem cells to neurons Scientists from the Zaugg and Noh group at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in neurons. more
Rome, 2 July 2020 Unravelling epigenetic reprogramming A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature Structural and Molecular Biology. more
General, 2 July 2020 Restructure of senior management Professor Heard said: "EMBL has grown significantly over the past decade including the addition of a new site at Barcelona, and we have ambitious plans for the future to ensure our research, services and training expand further for the benefit of our Member States, humanity and the planet." more
Hinxton, 1 July 2020 Welcome: Ellie McDonagh Identifying drug targets is a complex yet crucial process in the life sciences. Open Targets is an innovative partnership between academia and the private sector that provides a platform for identifying potential drug targets linked with certain diseases and selecting or prioritising the most promising ones. Ellie McDonagh, the new Open Targets Informatics Science Director, wants to build on available resources and keep the partnership at the cutting edge. more
Heidelberg, 30 June 2020 EMBL boosts national and international sharing of genomic data A national consortium including EMBL and the German Cancer Research Center (DKFZ) is set to launch the German Human Genome–Phenome Archive, creating an invaluable bridge between fundamental biomedical research and applied healthcare. more


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Villa named in race to sign Nketiah on loan from Arsenal
Aston Villa's search for a striker has seen the club turn to Arsenal youngster Eddie Nketiah, according to the Daily Mail.
The Mail names Villa as one of four clubs that the 20-year-old could join, with a decision poised to be made within the next 48 hours.
Championship trio Bristol City, Nottingham Forest and Sheffield Wednesday are also reportedly in the running to sign the striker, according to the report.
Read Aston Villa verdict
Highly-rated from a young age, Goal have previously named Nketiah as the number one up and coming player for fans to look out for at Arsenal.
However, this could be a risky signing for Villa to make and with the club in the midst of a relegation battle, you'd hope that Dean Smith and his staff are looking at further targets to follow the potential arrival of the young striker.
Aston Villa are simply not in a position where they should be shopping for potential, languishing in the bottom three they must consider targeting players who can provide immediate improvement and experience to boost their survival chances.
It could be a huge ask of Nketiah, who started just twice during a failed loan spell at Leeds earlier this season, to make the step up into the Premier League and walk straight into a struggling Villa side to provide the goals that could potentially keep them in the top flight.


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|[Book] Lethbridge-Stewart: Moon Blink
About the Book
July 1969, and mankind is on the Moon. Both the United States and Soviet Russia have lunar bases, and both are in trouble.
Back on Earth, Anne Travers has learned she is about to be visited by an old friend from America, Doctor Patricia Richards. Lance Corporal Bill Bishop is aware of the visit, and is on hand to meet Richards.
She brings with her a surprise, one which the Americans and Russians wish to get their hands on. But the only man who can truly help Anne, Colonel Lethbridge-Stewart, is away in Scotland.
It's a game of cat and mouse, as Anne and Bishop seek to protect the life of an innocent baby –
The book features a cover from Adrian Salmon, who also provided the artwork for last year's The Schizoid Earth and Mutually Assured Domination. Salmon said: It was an honour to be chosen to draw Sadie's cover for Moon Blink. We went for something emblematic echoing the great Target covers of yore. I ended up sending two colour versions which Shaun brilliantly combined to make the final cover.
Written by Sadie Miller
More Lethbridge-Stewart Series Books from Chicago Sci-Fi Store
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Who's behind We Collect Postcards?
Have you wondered who's behind "We Collect Postcards?" Well, we'll tell you more about us in this section.
We are Miruna and Marius, a couple with a common passion: travelling.
We live and work in Madrid, but every time we can, we go on short trips or long travels. We love traveling, discovering new places and cultures, enjoying nature, getting lost in new cities and photographing everything.
It's been six years since our first trip together, which was a weekend getaway to Fuengirola (Malaga) and over this time we have collected lots of experiences, memories, and photographs that we want to share with you.
We would also like to share all the tricks we have learned over the years, the trips we take, the beautiful places we visit and how to travel on a budget.


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and 4 others
Our group consists of writers at all levels of writing experience. Our meetings are usually held on the first Saturday (at 11:00 a.m.), the third Saturday (at 11:00 a.m.), and the last Wednesday (at 7:00 p.m.) of each month. But, sometimes this varies and the meetings are held on different Saturdays/Wednesdays in the month. Even though our meetings sometimes take place at restaurants, there is never any pressure to order food. We usually have about 5-10 people in attendance at each meeting. Hope you can join us soon!
Online event


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Puppy she has been raising for a year turns out to be a white fox
Puppy she has been raising for a year turns out to be a white fox
When Ms. Wang first met this fluffy white puppy, she knew that the baby dog would be a perfect addition to her family. She put her heart to help shape the tiny creature into a well-behaved adult dog, only to discover that her lovable pet was actually a wild fox!
This presented Ms. Wang with a heartbreaking dilemma – abandoning the animal she loved so much in the past year? Or keep it knowing that he could never live a happy and fulfilled life in nature?
"The fur became thicker when she was three months old," Wang said of the dog-like development of the creature. "His face has become sharp and his tail has become longer than that of a normal dog. Other companion dogs seemed to be afraid of my pet, so I walked him on a leash. "open next page to see more


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2 bedrooms plus small 'sleepout' style room. ...
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- © 2019 American Society of Plant Biologists. All Rights Reserved.
Newly synthesized proteins must be folded to form their proper three-dimensional structures. Stresses perturb protein folding, thereby leading to the hyperaccumulation of misfolded or aggregated proteins. Such disrupted proteostasis causes proteotoxic stress that impairs cellular functions, and organisms must refold or remove misfolded proteins to maintain healthy growth. Molecular chaperones that disaggregate misfolded proteins and the cytoplasmic 26S proteasome, which shreds ubiquitinated proteins, are the predominant players in the response to misfolded protein accumulation in eukaryotes (Saibil, 2013; Amm et al., 2014).
In this issue of Plant Physiology, to further define the roles of the molecular chaperone protein HEAT SHOCK PROTEIN 101 (HSP101), McLoughlin et al. (2019) assessed the intracellular localization of GFP-labeled HSP101 during the adaptation of Arabidopsis (Arabidopsis thaliana) plants to a heat stress. The authors used an experimental system consisting of two sequential high temperature treatments. The first treatment is a 1.5-h incubation at 38°C as an acclimation to heat stress. Following 2 h of growth at 22°C, plants are subjected to second high temperature treatment at 45°C for 1 h as a heat shock treatment. Then, the treated plants are grown at 22°C again as a recovery period. The authors found that HSP101-GFP transiently appears as small, cytoplasmic dots in various tissues during the heat stress treatment (Fig. 1).
Previous studies revealed that heat stress induces the formation of a type of membrane-less organelle termed a stress granule to alleviate proteotoxic stress (Cherkasov et al., 2013; Mitrea and Kriwacki, 2016). HSP101-GFP–labeled foci, which appeared to move gradually, were temporally associated with stress granules labeled by a stress granule marker POLY(A) BINDING PROTEIN 2–red fluorescent protein fusion (Sorenson and Bailey-Serres, 2014). The heat stress-induced HSP101 foci also showed transient colocalization with the puncta that were visualized by a regulatory subunit of 26S proteasome REGULATORY PARTICLE NON-ATPase 1a-red fluorescent protein fusion. The biochemical identification of HSP101-interacting proteins also suggested the interaction between HSP101 and 26S proteasome subunits including REGULATORY PARTICLE NON-ATPase 1a. In the hsp101 mutant plants, the increase in insoluble or ubiquitinated proteins after heat shock is enhanced compared with wild-type plants. These findings indicate a cooperative role of HSP101 with the 26S proteasome to degrade ubiquitinated proteins produced by heat shock stress.
The comparison of protein status in soluble and insoluble fractions between wild-type and hsp101 plants through MS spectrometry supported the conclusion that HSP101 disaggregates numerous proteins to help refolding or proteasomal shredding. Overall, the current study points to an important role of HSP proteins in the coordination between stress granules and the 26S proteasome system to overcome impaired proteostasis due to heat stress. Interesting questions are how and why HSP101 transiently forms cytoplasmic foci in response to heat stress. Are there large protein complexes containing the components of stress granules or proteasomes? Are aggregated proteins also concentrated there? The mechanism and physiological importance of the transient formation of HSP101-containing foci remains uncertain. Further characterization of plant adaptive strategies for proteotoxic stress would allow researchers to establish effective approaches to generate stress-tolerant crops.


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RICHMOND _ AARP Virginia was one of more than 60 organizations today who urged the General Assembly to implement Medicaid expansion without delay.
"Everyone should have access to affordable health care; that includes 62,000 Virginians 50- to 64-year-olds who have lost their jobs or are struggling in jobs without health insurance and can't afford to buy private insurance," said AARP Virginia State Advocacy Director David DeBiasi.
Starting January 1, 2014, millions of hard working Americans will have health insurance through expanded Medicaid eligibility, but 400,000 Virginians will be needlessly waiting, DeBiasi said.
Virginia legislators have recognized the importance of expanding Medicaid under the Affordable Care Act, but are considering a bill to postpone accepting federal funding until at least July 1, 2014 and maybe longer.
"The poorest Virginians would continue to needlessly go without health care for six months while the Commonwealth loses $5 million dollars a day in Federal funding," DeBiasi said.
AARP Virginia urges lawmakers to do the right thing: adjust the budget so Medicaid expansion can begin on January 1, 2014 like it will in other states.
If Virginia delays expanding Medicaid:
• 400,000 low income Virginians will remain uninsured. Most will be unable to get private coverage through the health care exchange, leaving a huge gap in coverage.
• hospitals that serve the uninsured will lose more money.
• private health insurance premiums could rise even higher because of ongoing uncompensated care and fewer people in insurance risk pools.
• Virginia loses the economic benefit of over $2 billion in federal spending each year and continues to pay for health programs and services for indigent care with state or local money.
• Virginians' federal tax dollars will help people in other states.
To learn more about AARP Virginia, like us on Facebook at www.facebook.com/aarpvirginia and follow @AARPVa on Twitter at www.twitter.com/aarpva.
AARP is a nonprofit, nonpartisan organization with a membership that helps people 50+ have independence, choice and control in ways that are beneficial and affordable to them and society as a whole. AARP does not endorse candidates for public office or make contributions to either political campaigns or candidates. We produce AARP The Magazine, the definitive voice for 50+ Americans and the world's largest-circulation magazine with nearly 35 million readers; AARP Bulletin, the go-to news source for AARP's millions of members and Americans 50+; and our website, AARP.org. AARP Foundation is an affiliated charity that provides security, protection, and empowerment to older persons in need with support from thousands of volunteers, donors, and sponsors. We have staffed offices in all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands.
By Ginger Thompson , February 06, 2013 04:35 PM
About AARP Virginia
Contact information and more from your state office. Learn what we are doing to champion social change and help you live your best life.


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Service personnel in Iraq are seeing two different wars, according to Congressman Tom Osborne.
Nebraskans are seeing only one. The war that is shown on the news.
"The last two times I was in Iraq, I heard comments from soldiers that they see two different wars," Osborne said. "The one seen on CNN with the beheadings and the bombings, and the one they see. The average American doesn't realize what they are doing over there. They never see the positive things. Soldiers are doing good things and seeing progress."
Osborne cites an 80 percent increase in school attendance in Iraq. Most of the increase is due to girls being allowed to go to school. Three thousand schools have been renovated, and 30,000 teachers have been trained.
"Ninety-five percent of the children have been vaccinated for the first time in their lives," Osborne said. "The monthly income has doubled since last year. Small businesses are coming up and there are a million more cars on the road."While traveling in Iraq, the soldiers Osborne talked with told him to come back home and tell people what they are doing.
Osborne said he believed that the scheduled elections in Iraq would take place.
"I will predict that there will be an election and a good turnout. And people will get hurt," he said.
"The Iraqi people are determined to have elections," Osborne said.
On his trips, Osborne said he visited with soldiers and Iraqi citizens.
"A variety of sources close to the situation tell me that positive things are happening," Osborne said.
"It's not all a bed of roses over there," he said. "Our military people have done a fabulous job."
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A Tale Of Two Wars In Iraq the one on CNN, and the one over there.
Posted 13 January 2005 - 01:28 AM
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Casey Urges Shell to Move Forward with Beaver County Ethane Cracker Plant
Cracker Plant Has Potential to Create Jobs, Grow Southwestern Pennsylvania's Economy / Since 2012, Casey Has Pushed for Cracker Plant Project / In Letter to Shell, Casey Cites Region's Skilled Workforce
Washington DC- Today, U.S. Senator Bob Casey (D-PA) announced that he has sent a letter to Mark Quartermain, President of Shell Energy North America, urging the company to continue to move forward with its plan for an ethane cracker plant in Beaver County. The project has the potential to create a significant number of jobs while continuing the region's role in producing natural gas and in developing associated industries. In his letter to Shell Energy, Casey cited the region's highly skilled workforce in pushing for the project. Casey first urged Shell in 2012 to take steps towards building a cracker plant in Beaver County.
"Moving forward with this cracker plant will bring jobs to Southwestern Pennsylvania and continue the region's nationally recognized role as a leader in natural gas production and in related industries," Senator Casey said. "The region is ready for this project and I'm urging Shell to take the next steps in making the cracker plant in Beaver County a reality."
The full text of Senator Casey's letter can be seen below:
December 9, 2013
Mr. Mark Quartermain
Shell Energy North America, L.P.
Two Houston Center, Plaza Level I
909 Fannin Street
Houston, Texas 77010
Dear Mr. Quartermain:
Throughout the last two years, I have encouraged Shell to build an ethane-fed cracker plant in Pennsylvania. As 2013 draws to a close and your company prepares to make its final decision on whether to build a plant in the Appalachian region, I want to remind you that Pennsylvania has everything Shell needs to make this considerable project an enormous success.
The Commonwealth has an established work force, access to water, communities with a long history of working cooperatively with industry, an extensive rail transportation network and appropriate real estate. Pennsylvania's outstanding higher education network will advance Shell's innovation. Further, Shell is uniquely positioned to supply a cracker plant with ethane from its nearby wells, as well as those of other producers.
I am hopeful that Shell will use all that Pennsylvania has to offer to explore natural gas as an energy source and to supply the increasing demand for petrochemical feedstock and products. As you know, the end uses for these substances will help stimulate manufacturing capabilities in numerous categories, including fibers, agricultural chemicals, plastics and automotive products.
Petrochemical plants are not without risks, but I have faith that Shell's long experience will help it to design and build its facilities to run cleanly, safely and efficiently. I am optimistic that a Shell facility will serve as the foundation of an industrial and manufacturing expansion that will bring thousands of construction and production jobs to Pennsylvania. I encourage you to take this opportunity to build on Pennsylvania's long manufacturing history and invest in the region.
Thank you for interest in investing in Pennsylvania. I look forward to working with you.
Robert P. Casey, Jr.
United States Senator


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Indian mountaineer Arjun Vajpai has become the youngest person in the world to scale six peaks of over 8,000 metres. On May 20, the Noida-based mountaineer summited Kangchenjunga, the third highest mountain in the world, to achieve this honour.
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