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Dec 06, 2019 (Market Insight Reports via COMTEX) -- Global "Smart Grid Cyber Security Market" 2019 Research report provides information regarding market size, share, trends, growth, cost structure, global market competition landscape, market drivers, challenges and opportunity, capacity, revenue and forecast 2025. This report also includes the overall and comprehensive study of the Smart Grid Cyber Security Market with all its aspects influencing the growth of the market. This report is exhaustive quantitative analyses of the Smart Grid Cyber Security industry and provides data for making strategies to increase the market growth and effectiveness.
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Top Companies Are Covered In Smart Grid Cyber Security Market Report:
BAE Systems, IBM, IOActive, Lockheed Martin, AlertEnterprise, AlienVault, Black and Veatch, Cisco Systems, Intel (McAfee), Entergy Services, HP, N-Dimension Solutions, Siemens, Eaton, Sophos, Sourcefire, Symantec, ViaSat, VeriSign, Honeywell International, N-Dimension Solutions, AlertEnterprise, Leidos, Sentryo
Smart grid cyber security is the protection against serious cyber threats that affect the users in the smart grid network globally. Cyber security of the smart grid has been an area of concern for the power utility sector, due to frequent exchange of sensitive information that takes place via communication networks such as the internet, intranets, extranets, and corporate networks. Growing electricity demand will increase the need to deploy smart grids for power supply, that additionally demand for smart meters that are used to read the power consumption rates. To protect the smart meters from cyber-attacks, there is increased adoption of smart grid cyber security solutions for consumption applications.
Smart Grid Cyber Security Market segment by Type, the product can be split into:
Smart Grid Cyber Security Market segment by Application, split into:
Distribution and Control
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North America (United States, Canada and Mexico)
Europe (Germany, France, UK, Russia and Italy)
Asia-Pacific (China, Ja3D Depth Sensor, Korea, India and Southeast Asia)
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subset: commoncrawl


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Certainly, due to many causes, dental surgery is required for anybody. But the question is- How long does it take to recover from dental surgery? Significantly, the answer is not simple and depends on the dental surgery types. More complex surgery need a long time for recovery. Let's go into the deep!
Tooth extraction:
The stretches are removed after approximately 7 days. Due to the surgery pain, bruising, swelling, etc it may take longer. After the stretches are removed, the full recovery time will be 7 to 10 days more, depending on the person.
This type of surgery includes Root canal treatment and dental pulp. The recovery time will be 1 week or less.
The dental prosthetics surgery needs different times to recover, depend on the type. The Prosthodontics examples are- Crown (caps), Dentures (false teeth), Implant, Veneers, Bridge and Implant-supported prosthesis.
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Adding dental braces is no much painful. After 5-7 days the initial discomfort will not fellable. Normal food can be eaten after 7 days. The recovery time or the braces removing time will depend up to the Dental surgeon.
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They are not a simple procedure. They are performed in situations like- injuries, many diseases, defects in the jaws, neck, head, face, etc, soft tissues of the maxillofacial or oral region. The recovery time can be up to 30 days depending on the surgery type.
Periodontology surgery:
This surgery is related to structures of teeth and managing them. So this kind of surgery's recovery time can take up to 15-25 days.


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Men to drool over
Created | Updated Sep 12, 2005
So - here is a summary of the drool thread. Well, more a list of people that the participating ladies have mentioned. With links to pictures for us all to make our own minds up. Or just drool. Don't be surprised that a lot of the characters are from science fiction series - this seems to be the main source - delivered weekly, or even daily, into your own home.
Picture the Scene
So, imagine half a dozen 40-something females with a TV and video and endless cups of tea - main item of wardrobe being bibs for collecting drool, which frequently need changing!
(If there are any men listening in: eat your hearts out, buddies - this is serious hard-core drooling and not for mere mortals)
We overhear the odd snippet of conversation:
"Do you think we should campaign for a drool smiley?"
"So many good looking men to talk about and as there usually pretty girlies in these series as well there are no arguments as to what to watch!"
"If I come across any other noteworthy drool-inducing totty I will inform her of this thread immediately. In fact, I think we all should swear some kind of allegiance, to let each other know, so we can drool and discuss later"
"I'm married. Although my husband is working most evenings leaving me to letch with abandon."
"I have kids older than him! (Shane of Westlife)"
"I dream of being kissed like my heroes kiss their women."
"Incidentally, how come Brits frequently portray the "baddies" in US television series or films? Is it the accent or just the calibre of our actors? Does anyone remember the sexy Alan Rickman up-staging Kevin Costner in "Robin Hood" as the Sheriff of Nottingham and he was absolutely brilliant in that film with Bruce Willis...What was it called now? It had lots of buildings, cars and planes exploding...)"
"... so I confessed and he has now promised to buy me a flasher's mac for Crimbo!"
"When I fantasise about a 'phone acquaintance, he is usually tall, dark and handsome until proved otherwise. *Wanders off for a very cold showers muttering something about nice young men with muscular biceps, blue eyes and gorgeous smiles*"
"..can still remember those full on drools! Now it is a little more sedate, but my heart does flutter, or perhaps it's palpitations at my age!"
"I like to close my eyes and imagine that I am the one in their arms being kissed "
"Have any of you ladies found that as you've aged, you've found yourselves attracted to men that you wouldn't even have given a second glance fifteen or twenty years ago? If so, do you think it's because we're subconsciously seeking different attributes and are more interested in companionship?"
"Confidence is sexy. Young women haven't a clue - which is fair enough, there's got be something to keep us oldies interested (and interesting)."
"I wonder if Bill Gates actually has women throwing themselves at him?
"as I have got older, my taste in men has got younger..."
"Jonathon Ross, I've been trying to work out whether he's fanciable or not....I'd probably watch Voyager episodes with him if he popped round with a bottle of wine one evening, but we'd have a good laugh."
'Anyone got a fan?
I really need to reduce my temperature.'
NB None of the quotes have names attributed to them, for the simple reason that I would have to put my own name, too! If you really want to know how kinky each one of us is, just read the whole conversation. (.. Posts to date! ... 2001)
Star Trek; Voyager, etc
I am looking for a suitable link for Seven of Nine (the one I had here was moderated off)- 'I mean, who can fail to be impressed with Seven of Nine?'
Dax and Worf in red leather. ~drool~
Tim Russ, who plays Tuvok.
"I sometimes have a hankering to cuddle up to the holo-doc!!!" (link is to a German page, but it's a good picture)
"My fancy from old trek was Kirk."
Another entry by Fiery Fred (compares film and TV series).
The main subject of the ladies' swooning is most definitely Daniel Jackson (Michael Shanks)
Not to forget Jack (Richard Dean Anderson)
There are even those who dote on Teal'c
'This morning I got up half an hour early to record the first ever ep of Stargate... and found myself dribbling
into my breakfast over Richard Dean Anderson in a uniform...'
See Galaxy Babe's Farscape Appreciation Society for all relevant links.
' ... there are some yummy females in Farscape'
'Farscape. That Ben Bowder (or whatever his name is) is a real baben'A what???
the blue plant lady!} too! 'She is the reason I got Retro to watch Farscape the other week! Though he was disappointed she wasn't wearing something see-through, which she normally does! I can't take my eyes off her, whenever she is on screen {unless John Crichton is in the same shot of course} her make up is fantastic. Last week when she cried, she cried blue tears, but her make-up didn't run, I wonder how they did that?'
'...waiting around for Tyr (Keith Hamilton-Cobb) to grab Beka.' 'Baggy first to put my hands under that designer chainmail.'
And ladies - watch the knicker elastic when you go to this site.
'...otherwise not much good - a nice eyeful of Kevin Sorbo in his black leathers'
My choice is Seamus Harper. Reminds me of Tim Roth. But better. Those dimples - those mischievous eyes'
The Author's modest little list of favourites
James Purefoy, who played Prince Edward in 'A Knight's Tale'. My favourite picture of him.
I've just discovered this and can't resist it: A picture of James Purefoy looking sexy with some cherries.
Hugh Jackman, who performed some amazing feats in the film "Operation Swordfish". He also played Wolverine (X-Men).
To be continued..................


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From the beach of Cancun and the historic buildings of Mexico City all the way through to the party town of Tijuana, most people know all about the top tourist attractions of Mexico.
Only Mexicans know that it is the small towns well off the beaten track that really ooze all of the culture and atmosphere of Mexico.
Here are some of the most special small towns that will remind you of home:
Valle de Bravo
Located two hours from Mexico city, this idyllic town sits on Lake Avandaro and is regarded as one of the nicest colonial villages in Mexico.
Ooozing charm and an authentic Mexican feel, it's no wonder that those who grew up in this special place are not quick to forget about it.
The colonial town centre boasts enough to marvel at while traditional buildings with terracotta roofs compliment the surrounding countryside.
In the summer months, this town is awash with keen surfers looking for the quickest route to the beach.
But for residents, this town is a charming fishing village which offers stunning seaside views and a small population of just 4,000.
For those who grew up there, Pátzcuaro appears to be unspoilt by modernity.
Its cobbled streets and old buildings complement its laidback atmosphere free from crowds. Life in this unique town is characterised by a strong and inclusive community that seems impossible to truly leave behind for those who move away.
Reconnect with Mexico today and send a Telcel recharge to a loved one back home.


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Each faction positions value only on a particular virtue, which its participants work to plant throughout their lives. There is Abnegation, which values selflessness, Amity, which values peace, Erudite, which values know-how, Candor, which values sincerity, and Dauntless, which values bravery.
Beatrice Prior is a sixteen-year-old member of Abnegation. She and her brother Caleb, who is almost a year her older, take the aptitude test that will certainly inform them which faction they are most suitable for. The examination contains a likeness of an encounter with a ferocious pet dog. Beatrice shows an aptitude for three various factions, Abnegation, Erudite, and Dauntless, and this suggests she is something called Divergent. She is warned to never say to anyone of her results – it is harmful to be Divergent. After much contemplation over whether to remain in Abnegation or change factions, Beatrice decides to change to Dauntless, and Caleb transfers to Erudite.
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Visiting Day shows up, and Tris's mommy comes to visit her in her new faction. She knows a suspicious quantity regarding the Dauntless compound, which leads Tris to think that her mama could have originally been Dauntless. Tris finds out that Abnegation members are now banned from getting in Erudite.
As stages two and 3 of initiation commence, Tris from Divergent pdf starts ahead into her own in Dauntless finally. She goes zip lining below the Hancock building with the Dauntless-born initiates, shows severe proficiency in worry simulations, and comes to be better to Four, which slowly begins to open to her. Tension is brewing in between 2 of the factions, Erudite and Abnegation, and Erudite continually makes assaults on the Abnegation administration. Initiation is still the most important point to bother with, however, and at the end of phase two she receives a shock; she's shown up leading. Considering her a hazard, Peter and Drew attack her with the assistance of Al, which utilized to be her close friend. 4 saves her prior to they kill her. Al is ruined with exactly what he's done and kills himself because of this.
After a bad day in training, Tris leaves the Dauntless mixture without mentioning to any person. There, she has an encounter with Erudite leader Jeanine Matthews, which Tris suspects of colluding with Dauntless to eliminate the Divergent. When she returns to Dauntless, Tobias notifies Tris that Erudite is preparing a battle versus Abnegation and will use Dauntless to battle it.
Initiation day comes, and Tris goes with her last evaluation, a simulation including each one of her fears that she should dominate, one after an additional. She's extremely effective and rates first, coming to be a formal member of Dauntless. Nevertheless, she, later on, recognizes that in the enjoyment of the day, the Dauntless leaders injected everybody with a likeness serum that day, calling it a tracking device. She understands they need to be lying, which Erudite will use this serum as a simulation to move Dauntless to combat Abnegation for them.
That evening, everybody in Dauntless wakes up in a sleepwalking trance except Tris; she can stand up to the simulation considering that she's Divergent. When Eric attempts to "inadvertently" kill Tobias, the two fight back and are taken to Erudite headquarters, where Jeanine takes Tobias in for likeness testing and sends out Tris, which was fired in the shoulder and consequently of no usage to her, to be carried out. The following early morning, Tris is taken to a large container, similar to the one that appears in her concern likeness, and is to be sunk.
Tris recognizes the only way to stop the eliminating is to quit the simulation completely, so she, her papa, her brother, and Marcus Eaton head to the Dauntless control room to close it down. Tris is wrecked, yet she keeps going, and eventually makes it to the control area where none various other than a serum-controlled Tobias is controlling the likeness and divergent pdf.
Tris, Tobias, Caleb, Marcus and Peter going off the city, wishing to locate safety in the tranquil Amity material.
She knows a dubious amount of the Dauntless compound, which leads Tris to think that her mama might have originally been Dauntless. As phases 2 and three of initiation commence, Tris starts to come into her own in Dauntless at last. When she returns to Dauntless, Tobias cautions Tris that Erudite is intending a war against Abnegation and will make use of Dauntless to combat it.
That evening, every person in Dauntless wakes up in a sleepwalking trance except Tris; she can resist the likeness due to the fact that she's Divergent. Tris recognizes the only method to stop the getting rid of is to quit the likeness completely, so she, her dad, her bro, and Marcus Eaton head to the Dauntless control room to shut it down.
More here http://divergent-series-pdf.blogspot.com/
Rich Dad Poor Dad is a book by Robert Kiyosaki. It advocates financial independence and building wealth through investing, real estate investing, starting and owning businesses, as well as increasing one's financial intelligence Hi guys I found the pdf to rich dad poor dad. I have placed a link in the post for you guys to view when you are ready. The page posted also has some other link to popular book so read up and enjoy guys.link is also in the photo enjoy guys!
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Rich Dad's running motif is that you'll never ever obtain abundant by chasing after a greater income– obviously, the Protestant job principles is for fools. It transforms out that whenever Kiyosaki supplies an instance from his life, it practically usually includes real-estate conjecture. (It's difficult to evaluate the honesty of his not-very-specific cases on this front, and as much as I could inform, press examination of Kiyosaki today has actually been restricted to bland meetings or face-value restatements of his publication's motifs.
To pad out the real-estate stories, Kiyosaki repetitively connects more finding out with even more publications, audiotapes, programs, and workshops. You'll be kindly to listen to, then, that Kiyosaki himself is doing his component to aid the have-nots with occasions like a $5,000-a-person, three-day program in Phoenix this weekend break.
Much cash Kiyosaki did or really did not make in the past, he's making a ton of money by offering the concept that he holds the secret to your economic future. In one of the lots of rationally imaginative flows late in the publication, he increases the unbelievable concept that Americans do not invest sufficient time attempting to imitate the effective– there's simply not more than enough hero praise out there. If there's much better evidence of exactly how incorrect this is compared to the success of Rich Dad, Poor Dad, I cannot assume of it.
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(It's challenging to evaluate the honesty of his not-very-specific cases on this front, and as much as I could say to, press examination of Kiyosaki today has actually been restricted to bland meetings or face-value restatements of his publication's motifs. To pad out the real-estate stories, Kiyosaki consistently connects additional discovering with even more publications, audio tapes, training courses, and workshops.
Click the download link to download your copy of Game of thrones pdf. This includes all of the seven books from the series including song of fire and ice, Clash of Two Swords, etc. The TV series is also very successful if not one of the most successful ever even though it is not suited for all ages because of obvious reasons. So leaving out the younger teenage audience (which is massive) this show still ranks in the top ten. Enjoy the links guys
Here's the very short model of a game of thrones pdf: Several remarkable residences battle a civil war over that ought to be king, while an ousted princess looks for her location on the planet, and the kingdom is threatened by some rising super ordinary risk in the north. Boom. Take that, Book-a-Minute.
Just what makes this book so difficult, to sum up, is that it's distinguished the point-of-view of 8 various characters and, well, there's a whole lot going on. Here's a key: A Game of Thrones can be damaged down into 3 tales:
(1) The longest part of this book mentions to just how the honorable Stark household deals with conspiracy theory and court national politics in the 7 Kingdoms of Westeros, with a specific focus on Eddard Stark, the father, and leader of the worthy family.
(2) A 2nd tale complies with the banished princess Daenerys, one of the last descendants from the previous royal household, as she matures on another continent.
(3) A 3rd story adheres to Jon Snow, the bogus son of Eddard Stark, as he matures in the north of Westeros. He is in the special army order called the Night's Watch, which is committed to safeguarding the civilized 7 Kingdoms from the dangers beyond the Wall surface.
Here's the slightly longer plot recap:.
(1) Court politics is less enjoyable compared to routine politics.
in Game of Thrones Eddard Stark is the lord of the north, yet he's good friends with (and less highly effective compared to) King Robert Baratheon. When Robert asks Eddard to be the Hand of the King (which is like being Perfect Minister, but less enjoyable), Eddard can't truly refuse.
The Stark family doesn't obtain along so well with the Lannister household. Given that Cersei Lannister is the queen, and her twin bro Jaime is a powerful knight, this is an issue. The 3rd sibling is Tyrion, and he seems like a fine guy: he's funny and smart (and a dwarf, by the means). Incidentally, the Lannister household has a key: Cersei and Jaime are incestuous. When he views the Lannister doubles in the act, this is so hazardous a key that Jaime tosses young Bran Stark from a tower.
Down in King's Getting, Eddard acquires recorded up in the court politics and conspiracy. Eddard of the Game Of Thrones does not recognize which to count on: should he trust his wife's old close friend, Petyr Baelish, which is now an effective politician (read: schemer)? Should he rely on the old sensible guy, Maester Pycelle, who seems to be an ally of the queen? Or the spymaster, Varys?
After one more killing effort on Bran's life, Catelyn from Game of Thrones pdf boils down to King's Landing with the knife that was made use of to attempt to get rid of Bran. (Thankfully, Bran has a wolf to protect him.) Petyr informs her that the knife is Tyrion's. So when Catelyn goings home in Game of Thrones and runs into Tyrion (coming back from the Wall), she chooses to take him detainee and takes him to view her entirely crazy sis. That does not go well and Tyrion succeeds his flexibility and a small army.
At the same time, Eddard learns that King Robert in the games he has a lot of bogus youngsters and they all have his dark hair, which is extremely various from Robert's children with Cersei. Cersei's 3 youngsters look a whole lot like … Jaime. Yeah. So now Eddard understands the huge trick, which isn't merely gross, yet is likewise a political issue: Cersei's children aren't true heirs to the seat. Eddard mentions to Cersei that he understands about her incestuous partnership and that she need to get out of the thrones. She reacts (we're paraphrasing right here): "You gonna make me? You and what military?".
Cersei apprehensions Eddard when Robert perishes (under mysterious scenarios). In the game of thrones pdf, She guarantees to secure his 2 little girls Sansa and Arya (both he pulled down to King's Landing) if, and simply if, he'll admit to treason. He does just this, and Cersei's child Joffrey now the king has Eddard eliminated.
Now there is a battle in Westeros for the Thrones: Eddard's oldest (trueborn) son, Robb Stark, is now in fee of the north and he has an army. Meanwhile, the Lannister army has been assaulting the Tully family members in the Riverlands. (It doesn't assist that Catelyn is a Tully by birth.) Although he's very young, Robb ends up being a respectable commander, even recording Jaime Lannister. HoweverRobb isn't certain that needs to be king of all Westeros, till his followers tell him that he ought to secede and be the king in the north, like in the aged days. It's amusing to see that also in fantasy globes, people still enjoy them some fond memories.
Right here there be … dragons?
More here on A Game of thrones pdf: gameofthronespdf.com
For more on the TV series : Check it out
I know we all love James and this fifty shades trilogy. On this page, I also have links to fifty shades freed and fifty shades darker. So you have many choices
Hi, guys guess what I found links to the fifty shades series how lucky must you guys be to get this. Download for free at your leisure. Of course leave a Facebook like on the linked download page if the page helped you a reading online option is also available, check out the link here.
Anastasia "Ana" Steele is a 21-year-old college senior going to Washington State College in Vancouver, Washington with her best buddy Katharine "Kate" Kavanaugh, who writes for their student newspaper. As a result of an ailment Fifty Shades of Grey pdf during, Kate convinces Ana to take her spot and meeting 27-year-old Christian Grey, an extremely successful and rich youthful entrepreneur. Ana is instantaneously attracted to Christian, yet likewise finds him daunting. Therefore she stumbles via the meeting and leaves Christian's workplace thinking that it went badly. Ana attempts to console herself with the idea that the 2 of them will probably not comply with each other once again. Nonetheless, she is surprised when Christian shows up at Clayton's, the biggest independent equipment store in the Portland location, where she works. While he acquires numerous items including wire associations, covering up tape and rope, Ana educates Christian that Kate would certainly like some pictures to go along with her article about him. Christian leaves Ana with his telephone number. Later on that day, Kate advises Ana to call Christian and organize a picture shoot with their digital photographer good friend Jos Rodriguez.
The next day in Fifty Shades of Grey pdf Jos, Kate, and Ana show up for the photo shoot at the hotel where Christian is remaining and Christian asks Ana out for coffee. Both talk over coffee and Christian asks Ana if she's dating anyone, specifically Jos. When Ana replies that she isn't really dating anyone, Christian begins to ask her about her family. During the chat Ana discovers that Christian is likewise single, however, is not "a hearts and flowers sort of man". This intrigues Ana, especially after he draws her out of the course of an approaching cyclist. Nonetheless, Ana thinks that she is not attractive good enough for Christian, considerably to the irritation of Kate.
Later on that night Ana goes out drinking with her pals and finishes up intoxicated dialing Christian, which notifies her that he will certainly be coming to pick her up since of her intoxicated state. Ana goes outside to obtain some fresh air, and Jos tries to kiss her in Fifty Shades of Grey, yet is stopped by Christian's landing. Ana leaves with Christian, yet not prior to she uncovers that Kate has actually been teasing with Christian's sibling, Elliott.
Ana takes place a date with Christian where he takes her in his chopper to his house. Once there, Christian firmly insists that she sign a non-disclosure arrangement restricting her to review anything that they do together, which Ana accepts authorize. He also discusses other documents, but first takes her to his playroom loaded with BDSM playthings and gear. There Christian educates her that the second deal will be one of dominance and submission which there will be no enchanting partnership, just a sex-related one. The deal even forbids Ana from touching Christian or making eye call with him later in Fifty Shades of Grey pdf. At this factor, Christian realizes that Ana is pure and agrees to let Christian take her virginity without making her sign the agreement. The two then make love.
The following morning Ana and Christian again have sex, and his mom, who arrives minutes after their sexual experience, is shocked by the conference, having actually recently thought Christian was homosexual because she had actually never seen him with a woman. Christian of Fifty Shades of Grey pdf later takes Ana out to consume, and he reveals to her that he shed his virginity at fifteen to among his mom's buddies and that his previous dominant/submissive connections fell short because of conflict. They prepare to comply with up once more and Christian takes Ana residence, where she uncovers several task offers and confesses to Kate that she and Christian have actually made love.
More here: http://www.readingsanctuary.com/fifty-shades-of-grey-by-e-l-james-pdf/
Other resources: https://sites.google.com/site/fiftyshadesdarkerpdf/


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Migraine Injections. home/Knowledge Base/Migraine Injections/. Forums, Portfolio. Popular Search:Migraine Triggers, Natural Remedies, Migraine Symptoms .
migraines.org national migraine association migraineur. Narcotic injections are used primarily in emergency rooms and medical offices. There are two main .
Buy Mycratine Migraine Relief Advanced Formula, 2 Fluid Ounce on Amazon.
Botox injections for management of chronic migraine headaches by Dr M Krishna
Botox injection for migraine. Mode of action of Botox and points of injection for treatment of migraine headache.
I dozed in and out but could tell relief was settling in.. . The last time I was in the ER for a shot for my migraines was 9 months ago, this is not a frequent thing for .
Dihydroergotamine injection is used to treat a migraine or cluster headache attack. This medication will only treat a headache that has already begun. It will not .


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2012-09-11, 01:31
(2012-09-10, 19:45)furii Wrote:(2012-09-10, 09:07)vicbitter Wrote:(2012-09-09, 23:54)furii Wrote: how long did you test the hd audio playback? you didn't get any alsa underruns causing the audio to briefly drop out? this occurs several times during movies currently with nvidia. would be interesting if it was confined to nvidia hardware.
I have nVidia hardware both an ION2 system and a GT520 and I don't suffer with audio drop outs... I run OpenELEC and we have a thread dedicated to the AudioEngine and this issue isn't being reported by others either...
interesting. someone else had reported it on a gt430 i believe. i'm running a geforce 210 which is almost identical to the ion2 chip the gt218 i believe. what version of the nvidia drivers are you using? i'm still on 290.10 as i had audio issues with the 295.xx release but have yet to try any 3xx.xx releases. i'm wondering if the audio dropouts are related to the nvidia drivers.
Interesting, i have a gt430, it looks like im on
Wonder if thats whats causing my DTS HD Master not to work...
Whats the recommended drivers to use for the gt430 ?
Many thanks,


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Earlier we got sanhok map in PUBG timi version 0.8.0, now Recently Timi studios has released PUBG Mobile Timi 0.9.0 update that is going to change the game-play totally forever enormously. PUBG Mobile Timi 0.9.0 brings a couple of major features that makes the game features identical to that on fortnite.
Recommended for you – How to enable HD/HDR graphics on PUBG Mobile on any android phone.
A new rifle, QBU88 has been added in the game that is similar to Mini14 which is available on PUBG Mobile global version and light speed or chinese version. But QBU gives you more stable firing ratio and has comparatively lower recoil force. You can add upto a 8x scope with the rifle, that makes this one perfect for both short range and long range. Now you can make multiple holograms of yourself. Basically hologram feature allows you to create a duplicate your body and it can move as you want. If you think there's a crew of enemy nearby, you can create one or more holograms and put them in-front of them to confuse them. While the enemies are killing your hologram, you can shoot and kill them from a distance. You may create 2, 3, 4 or as many holograms as you want in PUBG Mobile timi 0.9.0.
Checkout – Download PUBG Mobile Emulator [tenccent gaming buddy].
Another trap feature has been implemented on PUBG Mobile timi 0.9.0 update. You can place a trap anywhere on the ground, when a enemy will try to go over through it, the trap will spark a powerful electrical shock that will cause much damage or even death to the enemy. Also on PUBG timi version 0.9.0 you can build a tower structure anywhere. For a place where there's no high location, you can build your own tower to climb up and snipe down enemies. Apart from this, you'll find shield walls in the game which will protect you from the firing from enemy. 2-3 members can easily hide behind the shield, and no bullets or even frag grenade can break it. As well as you can put multiple shields together. This feature is coming to PUBG PC version too. Along with this, you can plant trees to make a better hiding place and a stone suit has been introduced in PUBG Mobile timi 0.9.0 version. Here I'm proving link to download PUBG Mobile 0.9.0 timi version on Android devices.
Also check – Guide to mic problem on pubg mobile.
PUBG Mobile Timi 0.9.0 Update Change-log –
- New QBU88 rifle.
- Create own Hologram.
- Trap feature.
- Build your own tower structures.
- Unbreakable shield wall.
- Create and break trees.
- Stone suit.
- Glitch fixes.
Download PUBG Mobile Timi 0.9.0 APK For Android –
Just go this link – http://pubgm.qq.com/d/index.html , it shall redirect you to the tenent qq official website from where you can download PUBG Mobile Timi 0.9.0 Update on your device.
Recommended – Download PUBG Mobile 0.9.5 Chinese Lightspeed Version for Android & iOS.
This features are currently in beta phase on PUBG timi version, and soon you'll get these all feature in light speed Chinese version too. But there's no information as of now about when this new features are going to be pushed in PUBG Global version, for more updates stay tuned with Gadgetcubes.


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The Great American roadside motel is making a comeback according to Vogue
It's time to rethink motels, according to style bible Vogue, who says that the iconic roadside lodging is making a chic comeback.
A story on Vogue website claims that a new generation of 'moteliers' are putting roadhouse inns firmly on the map once again, where faded facades and outdated interiors are being replaced with artisanal décor (The Alamo Motel, Los Alamos, California) and hipster elements like inflatable swans in pools (Lincolnville Motel, Lincolnville, Maine).
Roadside lodgings have long occupied an important position on the American landscape, both geographically and culturally. The sixties was the peak period for motels, as the rise in car travel created a new market for affordable accommodation – a Holiday Inn executive in 1963 put in succinctly when he said: "what we're trying to do here is finish the job that Henry Ford began. Ford put a set of assembly-line wheels under the average American. It's up to us to supply the assembly-line lodgings."
Cinematically, the motel has been immortalised many times, as a place for extra-marital trysts like in The Graduate, or as a sanctuary for fugitives, as in Thelma and Louise. By the 1980s however, motels were in decline, with many existing roadside locations bypassed by freeways and independent motels also had to compete with the rise of economy limited-service chains, offering low-frills accommodation. Now, the emergence of gentrified roadside lodgings may see travellers considering motels as desirable destinations once again.
According to Sarah Stocking, Lonely Planet Destination Editor, California, staying in a roadside motel is a quintessential part of the American road trip experience. "Some of them retain their mid-century modern architecture and nostalgic kitsch and many more have been restored to embrace the trends. Accommodations tend to be simple and straightforward, but with a lower price point than hotels, they are attractive alternatives with a bit of style," she says. "Motels are also a great option if you are nervous of the intimacy of Airbnb. California, which is a great place for a road trip, has some motel gems. Check out The Desert Lodge near Palm Springs, which offers guests an outdoor pool and shuffle board courts for easy afternoons in the sun while the Hollywood Downtowner Inn in Los Angeles is the last-standing Melrose-style building in Hollywood. In San Diego you can stay at The Pearl which features dive-in movies on Wednesday nights at the pool, swinging hammock chairs and board games in the shag-carpeted lobby."
For photographer Mark Havens, an enormous element of motels' appeal, revamped or not, is their authenticity. His book, Out of Season: The Vanishing Architecture of the Wildwoods is a ten-year photographic exploration of the New Jersey city's neon signage and Modernist buildings. "They're relics from one of the most evocative periods of our national history," he says. "They're real, a commodity that seems to be in short supply these days. They represent the aspirations and dreams of populace just out of a world war, newly-mobile, exploring the idea of the vacation for the working class."
The photographer believes this genuineness, so different to a 'big box' hotel experience, is what's spurring on the motel revival. "The second reason for the revival is that owners and designers are finally figuring out ways to adapt and enhance what's there to appeal to the desires of the modern traveller – and this is crucial – without ruining the authenticity of the overall place," says Havens. "That's a difficult balancing act, but when it's done right, it's unforgettable."
By Claire O'Mahony
Places from this article
North America


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Episode 389: 10-13-16
On this week's show, Jim interviews Scott and Belinda Sime – husband and wife team. They broker and invest in both residential and commercial real estate in Miami's "close-in" upscale markets. They discuss trends and opportunities they see in the marketplace. Also, Jim gives us an update on his wife Vivian's search for a kidney.
Coconut Grove, The Gables and More
Scott Sime is President and Chief Executive Officer of Sime Realty Corporation, a commercial and residential brokerage company. Prior to founding Sime Realty Corporation, Scott was the Managing Director of CB Richard Ellis (CBRE) in Miami-Dade County. Scott has been in Miami since 1962 and has more than 28 years of commercial real estate experience in the local market.
Sime has completed real estate transactions with The University of Miami, Baptist Health South Florida and PS Business Parks. He and his team have completed some of the largest commercial real estate transactions in South Florida including the sale of the Miami International Commerce Park valued at $206,000,000. Sime Realty Corporation currently represents a portfolio consisting of 35 properties totaling approximately 2,000,000 square feet.
Belinda Sime is ranked No. 1 in Coral Gables by number of homes sold. She has 97 homes sold (valued at more than $100,000,000) in the last 24 months. She works with buyers and sellers in Coral Gables, Pinecrest, Coconut Grove, South Miami and the surrounding areas.
They discuss what opportunities and trends Scott and Belinda see in the Miami marketplace.
Vivian Fried Kidney Transplant Update
Jim will also give an update on his wife Vivian's search for a kidney transplant.
For an update on Vivian Fried, watch her interview on WPLGTV10 in Miami: http://bit.ly/Viv10
For information on kidney donation, email email@example.com
Episode 389: 10-13-16


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In this article, we will go over the section My Partners and show you how to manage your current partners and invite new partners to resell your activities.
Within this section you will be able to:
If you have partners that are currently not using the Orioly application and you would like to invite them to resell your activities, all you need to do is click Invite new agents.
From here, you will need to add the company name and the email which you are sending an invite to.
To invite more than one company:
After receiving an invitation, your partners just need to set up a password, and a new account will be created for them.
Note: If you have previously selected activities for your partners, those will be the ones that they will see available within their Orioly application.
Within My Partners section, click the pen icon to access your Partner Details.
There you can:
Note: You can remove a partner by clicking the bin icon .
Check Pending Invitations
Any invitations with a pending status are located on a separate table. Things to take into account:
Now that you know how to invite and manage your partners, check the documentation regarding How to manage your activities.


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Wave Analysis
Last week, Ethereum broke out below the hourly support level 466.35, but ended up closing again above it. We expected a perfect pullback to the just broken level to pick a low risk buy position, but instead, the price rallied even higher. We're still waiting for this pullback to pick a long position. The anticipated bullish price rally is the continuation of the impulsive wave (c) to the upper side and should breakout above 618.17 towards 866.70 or even higher. We may only recommend a sell position below 466.35.
Trade Recommendation.
Buy Ethereum around 466.35 towards 618.17.
101% Double the volume
You may check other analytical reviews on FreshForex website. Source: freshforex.com.


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What's the difference between a simple and mixed triglyceride? Which is more common in nature?
Simple TGs: Same fatty acid in all 3 positions. Mixed TGs: 2 or 3 different fatty acids. Most naturally-occurring TGs are Mixed.
What can an elevated TG level predict independent of other risk factors?
-Risk of CV disease -Pancreatitis if several elevated (>1000mg/dL)
Name 5 functions of cholesterol.
1) Essential cell membrane component 2) Important and enriched in lipid rafts 3) Reduces membrane fluidity* 4) Precursor for bile acids and steroid hormones 5) Covalent modification of embryonic signaling proteins *From what I can find, this helps make the cell membrane a little more structurally rigid (in a good way), and makes it less permeable to small water-soluble compounds that would otherwise diffuse into the cell.
Name 5 classes of compounds derived from cholesterol and at least one specific compound in each class.
1) Androgens - Androsterone, Testosterone 2) Estrogens - Estradiol, Estriol, Estrone 3) Mineralocorticoids - Aldosterone, Corticosterone 4) Glucocorticoids - Cortisol 5) (Primary & Secondary) Bile Acids - Cholic acid (1°), Deoxycholic acid (2°)
Name 5 ways in which excessive cholesterol is cytotoxic.
1) Cholesterol crystal formation 2) Triggering apoptotic pathways 3) Forming toxic oxysterols 4) Disruption of functional & signaling membrane domains 5) Promotes atherosclerosis
Name the 4 major steps of cholesterol synthesis and the number of carbon atoms in each major compound
1) 3x Acetate (2C) --> Mevalonate (6C) 2) Mevalonate --> phosphorylated Isoprene (5C) 3) 6x Isoprene --> Squalene (30C) 4) Squalene --> Cholesterol (27C)
Name 3 substeps in the formation of mevalonate from acetyl-CoA and the enzymes that catalyze them.
1) 2 Acetyl-CoA → Acetoacetyl-CoA
via acetyl-CoA acyl transferase
2) Acetoacetyl-CoA + Acetyl-CoA → HMG-CoA
via HMG-CoA synthase
3) HMG-CoA + 2 NADPH → Mevalonate
via HMG-CoA reductase*
Rate-Limiting Step of Cholesterol Synthesis
Name 3 substeps in the conversion of mevalonate to isoprene.
1) Stepwise transfer of 3 PO43- from ATP to mevalonate.
2) Decarboxylation and hydrolysis forms the 5C isoprene
-Introduces a double bond
3) There are actually 2 isoprenes, which can isomerize back and forth
-Difference is location of double bond
Name 3 substeps in the formation of squalene from isoprene units.
1) 2 isoprene → geranyl pyrophosphate
-one of each isoprene isomer is needed
2) geranyl pyrophosphate + isoprene → farnesyl pyrophosphate
3) 2 farnesyl pyrophosphate → squalene
-squalene is phosphate-free
Name 3 substeps in the conversion of squalene to cholesterol and the enzymes that perform each step.
1) squalene + NADPH + O2 → squalene 2,3-epoxide
via squalene monooxygenase
2) squalene 2,3-epoxide → lanosterol
via cyclase
3) lanosterol → cholesterol
multistep - specifics not listed
Where does cholesterol synthesis diverge between animals and plants and fungi?
The fate of squalene 2,3-epoxide differs.
Animal: Lanosterol → Cholesterol
Plants, Fungi: Stigmasterol, Ergosterol
1) Where is most cholesterol synthesized in the body?
2) In what forms?
3) What forms are later converted from cholesterol in other tissues?
1) Liver
2) Bile acids, Biliary Cholesterol, Cholesteryl Esters
3) Other tissues form steroid hormones, some others
How do bile acids work?
They surround fat droplets and help to emulsify them. This increases the surface area available for attack by lipases.
Which are more non-polar: cholesterol or cholesterol esters? What is a consequence of this?
Cholesterol esters. The added hydrophibicity makes then unable to enter membranes.
Which LP class contains the most:
1) Protein
2) Phospholipids
3) Free Chol
4) Chol esters (CEs)
5) TGs
1) Protein: HDL
2) Phospholipids: HDL
3) Free Chol: VLDL/LDL
4) Chol esters (CEs): LDL
5) TGs: Chylomicrons
What is the surface of a lipoprotein particle composed of?
What is the interior composed of?
Surface: apolipoproteins, phospholipid monolayer
Interior: cholesterol, cholesterol esters, TGs
A lipoprotein's density is [directly, inversely] related to its size.
Name the major subclasses of lipoproteins in order of increasing density.
1) Chylomicrons
2) VLDLs
3) VLDL remnants
4) IDLs
5) LDLs
6) Lp(A)
7) HDLs
Name the identifying apolipoprotein (apoLP) and a major function/characteristic of:
1) Chylomicrons
2) VLDLs
3) IDLs
4) LDLs
5) Lp(A)
6) HDLs
1) Chylomicrons: apoB-48, C, E; delivers chol & TGs from gut to tissues & liver
2) VLDLs: apoB-100, C, E; made in liver and delivers TG to tissues as fatty acids
3) IDLs: apoB-100, some C, E; short-lived LP between VLDL and LDL
4) LDLs: apoB-100 ONLY; stays in circulation longest
5) Lp(A): apo(a), apoB-100; an odd LDL-like particle - apo(A) is structurally sim(ilar to plasminogen
6) HDLs: apoA-I & apoA-II, C, E; generally good
Which LP class contains the least:
1) Protein
2) Phospholipids
3) Free Chol
4) Chol esters (CEs)
5) TGs
1) Protein: Chylomicrons
2) Phospholipids: Chylomicrons
3) Free Chol: Chylomicrons/HDL
4) Chol esters (CEs): Chylomicrons
5) TGs: HDL
Name 4 functions of apolipoproteins.
1) Help solubilize the LP particle in the circulation
2) Change conformation to adjust to changing lipid contents, compositions, and metabolic states
3) Can activate or inhibit plasma enzymes
4) Serve as ligands for cell surface receptors
Name the function(s) of:
1) ApoA-I
2) ApoA-II
3) ApoB-48
4) ApoB-100
1) ApoA-I: Activates LCAT, interacts with ABC transporter
2) ApoA-II: Inhibits LCAT, structural
3) ApoB-48: Chol & TG transport and clearance
4) ApoB-100: Binds LDL receptor to deliver endogenous chol
Which ApoLPs are most strongly associated with
1) increased risk of atherosclerosis?
2) decreased risk of atherosclerosis?
Increased risk: apoB-100, apo(a)
Decreased risk: apoA-I
How are triacylglycerols taken up by the gut? Where is this process mirrored?
In short, they are broken down, absorbed, then reformed.
In detail: bile salts emusify the fats, forming mixed micelles that are attacked by lipases. The lipases degrade TGs into fatty acids (FAs), which are taken up by the mucosa and converted back into TGs.
The process is mirrored in the capillaries: LP lipase converts TGs into FAs + glycerol, which are taken up by cells. Cells can resesterify these back into TGs (or utilize them as fuel).
What lipoprotein are TGs taken up in the gut packaged into for transport?
What protein mediates the absorption of cholesterol in the intestine? What drug inhibits this protein?
Protein: NPC1L1 (Neimann-Pick C1-Like 1 protein)
Drug: ezetimibe
Which transporters prevent the assimilation of plant sterols into the body by channeling them back into the intestinal lumen?
What disease results from mutations in these proteins?
How is it inherited?
What symptoms to these patients show?
Transporters: ABCG5 and ABCG8
Disease: Sitosterolemia
Inheritance: Autosomal recessive
Sxs: Accumulation of plant sterols in blood & tissues, associated with tendon & subQ xanthomas and markedly increased risk of premature CHD.
When can chylomicrons be detected in plasma?
Elevated for 3-6 hours after eating a fat-containing meal. No chylomicrons remain after a fast of 10-12 hours, except in patients with disorders in chylomicron metabolism.
What is the % fat content of a chylomicron?
What % of this is dietary TGs?
98-99% fat
85% TGs
What gives apoB-48 its name?
48% of the MW of apoB-100
What apoLP activates lipoprotein lipase (LPL), allowing lipoproteins to release free fatty acids for fuel to adipose tissue, heart, and skeletal muscle?
Where is lipoprotein lipase (LPL) located?
LPL is bound to capillary endothelium in various tissues. Lipolysis therefore takes place at the vascular endothelial surface.
(Heart, skeletal muscle, adipose tissue, mammary glands, others.)
What is the conseqence of LPL deficiency?
Lethal in mice: die of severe hypertriglyceridemia
1. How is LPL regulated?
2. What are LPLs cofactors?
3. Which of these cofactors allows for measurement of LPL?
1. Increased plasma glucose and insulin release upregulate LPL transcription to facilitate FA storage in adipocytes.
Conversely, LPL activity of adipose tissue falls during prolonged fasting or in diabetic ketoacidosis, preventing FA storage.
2. ApoC-II and heparin
3. Heparin, given IV, will displace LPL activity into the plasma, allowing its measurement
What happens to chylomicrons after they are depleted of dietary TG via LPL activity in the body tissues? What ligand:receptor interaction is necessary for this?
Chylomicron remnants go to the liver. There:
- apoE acts as a ligand for LDL receptor or the related LRP to stimulates endocytosis
- ApoB-48 is degraded
- dietary cholesterol is released into the liver
What is LRP? What is it for?
LDL receptor-related protein.
It is the backup receptor (behind LDLR) responsible for uptake and clearance of chylomicron remnants and VLDL.
ApoE deficiency causes what disease? What is a consequence of this?
Type III hyperlipoproteinemia
Increased TGs and cholesterol in the plasma due to impeded clearance of remnants
What LP particle is produced by the liver for transporting endogenous lipids? What stimulates the liver to synthesize this particle?
Particle: VLDLs
Stimulation: Increased flux of free FAs or increased de novo FA synthesis in liver
What apoLPs do VLDLs contain? Where are these proteins synthesized?
ApoB-100, apoC-I, apoC-II, apoC-III, apoE.
All constituitively synthesized in the liver.
Other than fat, excess of what food type can also be converted into TGs by the liver?
1) What enzyme transports newly synthesized TGs from the ER to sites of VLDL and chylomicron formation?
2) What is at these sites?
1) Microsomal tryglyceride transfer protein (MTP)
2) apoB-100 (VLDLs) or apoB-48 (chylomicrons)
1) A defect in microsomal tryglyceride transfer protein (MTP) causes what disease?
2) What is the pathophysiology of this disease?
3) What symptoms do patients with this disease exhibit?
1) abetalipoproteinemia
2) failure to produce any apoB-containing LP particles (chylomicrons, VLDLs, LDLs) - unable to concentrate TGs within these particles to form them
3) vitamin deficiency, steatorrhea, developmental delays
Which enzyme esterifies free cholesterol into cholesterol esters (CEs)?
Why bother making the CEs at all?
Acyl-CoA:cholesterol Acyltransferase (ACAT)
Better storage
Which isoform of ACAT is located in the intestine and the liver?
What does it do in the intestine?
Why might it be medically important?
Regulates the absorption of dietary cholesterol
Due to its function, is a potential pharmacological target for reducing blood cholesterol
In what tissues is the ACAT-1 isoform located?
1) Macrophages (including foam cells)
2) Adrenocortical cells
3) Skin sebaceous glands
In what ways are VLDLs and chylomicrons similar?
1) Both used to transport TGs to adipose tissue and muscle
2) In both, apoC-II activates LPL to release FFAs
(Think of chylomicrons as mainly for the exogenous pathway and VLDLs mainly for the endogenous pathway)
How is IDL formed?
IDL is essentially the TG-depleted remnants of VLDL
What is the half-life of VLDL remnants / IDL? What are the two fates possible for this lipoprotein?
t1/2 < 30min
Fate 1: 40-60% are cleared from plasma by liver via LDLR and LRP
Fate 2: LPL and hepatic lipase (HL) convert the remainder of remnants/ID to LDL by further TG removal. Virtually all LDL is derived from VLDL remnants.
What determines the rate of LDL production?
What is enriched in LDLs?
What's the major apoLP in LDL?
The rate of VLDL remnant clearance - the remainder of remnants that escape uptake become LDLs
Cholesterol is considered to be enriched in LDLs because TG has been removed.
ApoB-100 is the major apoLP
In the formation of LDL, which apoLP facilitates the removal of residual TG by hepatic lipase?
What receptor mediates the clearance of LDL particles?
What apoLP is the ligand for this receptor?
Why is this interaction clinically significant?
Receptor: LDL receptors
Ligand: ApoB-100
Significance: manipulation of hepatic LDL receptor gene expression is the most effective way of modulating plasma LDL levels
Name two conditions in which LDL become atherogenic.
1) Modification by oxidation
2) Uptake by macrophage scavenger receptors
True or False:
LDLs can carry cholesterol from the liver to muscle and adipose tissue like chylomicrons and VLDLs can.
How does the half-life of an LP correlate with its density?
The trend appears to be: as density increases, t1/2 increases.
Chylomicrons: 5-20min
VLDL: 30min-1hr
LDL: 2.5days
After endocytosis of LDL particles, what are the fates of the endosomal components?
1) After lysosomal fusion, apoB-100 and CEs are degrades to release amino acids, FAs, and cholesterol.
2) The LDL receptor, however, is segregated into vesicles and recycled to the cell surface.
Mutations in what protein are the most common cause of autosomal dominant hypercholesterolemia?
LDL Receptor (LDLR) - Over 900 known mutations
Name two endogenous hormones that can lower LDL levels. How do they accomplish this?
1) Thyroxine & estrogen
2) Enhancement of LDLR gene expression - increases LDL uptake
What is single most effective:
1) dietary alteration
2) pharmacological treatment
for hypercholesterolemia?
3) How do they both work?
1) Eat fewer saturated fats and cholesterol
2) Statins
3) Enhancing hepatic LDLR expression
[one would assume less cholesterol/fat itself would also help...]
What transcription factors mediate the regulation of LDLR expression?
Sterol Regulatory Element Binding Proteins (SREBPs)
SREBP cleavage activating protein (Scap)
[Nested acronyms should be illegal]
1) What serine protease descreases the expression of LDLR on hepatocytes?
2) How does the LDLR get downregulated, specifically?
3) Given the above, what would a gain-of-function mutation in this protease dispose a patient to?
4) How about a loss-of-function mutation?
1) Protease: Proprotein convertase subtilisin/kexin type 9 (PCSK9)
2) How: PCSK9 binds LDLR, and the complex of the two is internalized and targeted to the lysosome for degradation.
3) Gain: Less LDLR means more LDL. More LDL and cholesterol in plasma → increased risk of CHD
4) Loss: More LDLR means lower LDL cholesterol levels and protection from CHD.
Name a protein that, when mutated, causes autosomal dominant hypercholesteremia that isn't LDLR.
PCSK9 (Gain-of-function mutation)
1) What the hell is it?
2) What is its identifying apoLP?
3) Good or Bad?
4) Why?
5) Half-life?
1) What: An LDL-like particle
2) ApoLP: apo(a), which is covalently bound to apoB-100.
3) Bad.
4) Not discussed - may have anti-fibrinolytic qualities
5) t1/2: 3-4 days
What protein is apo(a) highly homologous to?
What structural domain causes apo(a) to vary in size?
A variable number of kringle IV repeats.
Name 7 ways in which HDL is atheroprotective.
1) Anti-oxidant
2) Anti-thrombotic
3) Anti-inflammatory
4) Reduces endothelial expression of adhesion molecules
5) Stimulates endothelial repair
6) Promotes endothelial function
7) Stabilizes atherosclerotic plaques
In general, LDL (deposits / removes) cholesterol (in / from) the periphery. In contrast, HDL generally (deposits / removes) cholesterol (in / from) the periphery.
In general, LDL (deposits / removes) cholesterol (in / from) the periphery. In contrast, HDL generally (deposits / removes) cholesterol (in / from) the periphery.
What are the most abundant apoLPs in HDLs?
1) ApoA-I (70% of protein)
2) ApoA-II (20% of protein)
3) ApoC
4) Lecithin-cholesterol acyl transferases (LCAT)
A loss-of-function mutation in what gene might cause HDL deficiency?
What risk would this present?
apoA-I gene.
Risk of accelerated atherogenesis.
(Conversely, a gain-of-function mutation likely protects against atherogenesis.)
1) What transporter promotes the release of cellular phospholipids and cholesterol to join apoA-I and form HDL?
2) What form of HDL is produced this way?
1) ATP binding cassette transporter (ABCA1)
2) Discoidal HDL, not spherical HDL
1) Mutations in ABCA1 cause what rare disease?
2) What is the pathophysiology?
3) What clinical symptoms are seen?
4) Are plasma cholesterol levels low or high?
1) Tangier disease
2) Defective ABCA1 results in severely reduced cholesterol efflux to apoA-I. Pooly-lipidated nascent HDL is rapidly metabolized, resulting to markedly reduced HDL levels and cholersterol deposition in various tissues (liver, speen, tonsils, peripheral neurons)
3) Enlarged spleens & tonsils. Tonsils are orange from carotenoid accumulation.
4) Notably, plasma cholesterol levels are very low.
1) What is another name for discoidal HDL?
2) Where is the majority of discoidal HDL formed?
3) What's godd about discoidal HDL?
1) preß-HDL
2) Liver and intestine
3) It's a cholesterol sponge that can acquire free, unesterified cholesterol from tissue cell membranes, including arterial wall macrophages.
1) What protein is important in the generation of spherical HDL from discoidal HDL?
2) How does it accomplish this?
3) What apoLP on HDL activates this protein again?
1) Lecithin-Cholesterol Acyl Transferase (LCAT)
2) LCAT associates with HDL and esterifies free cholesterol that is acquired by discoidal HDL. The hydrophobic CEs move to the core of the HDL particle, increasing its size and eventually making it spherical.
3) apoA-I
1) What protein promotes the release of cholesterol to already-spherical HDL?
2) In what tisses is it found?
3) What remodeling processes does this assist in?
2) Spleen, thymus, lung, brain, liver, and macrophages
3) HDL remodeling and alteration of cholesterol distribution on "donor" cell membranes.
Why is HDL remodeling important?
It influences the metabolism, function, and plasma concentrations of HDL.
1) What does cholesterol ester transfer protein (CETP) do?
2) Is CETP activity beneficial or harmful? Why?
1) Promotes the transfer of CEs from HDL to VLDL, IDL, and LDL in exchange for TGs.
2) Harmful. Inceased CETP means more CEs moved into LDL-like particles, which can deposit those CEs into tissues and cause atherogenesis. A known Japanese population of CETP deficient people have reduced CAD risk.
Name 4 functions Phospholipid Transfer Protein (PLTP).
1) Transfer of excess free cholesterol and phospholipids from cylomicrons and VLDLs to HDL
2) Needed for maximal activity of LCAT
3) Major role in generating preß-HDL (discoidal HDL)
4) Promotes phospholipid efflux to preformed HDL
1) What is the function of Hepatic Lipase (HL)?
2) When does HL act?
3) How do androgens and estrogens affect HL gene expression?
1) Function: Hydrolyzes TGs and phospholipids to generate smaller spherical HDL particles. These smaller particles can recirculate and soak up additional free cholesterol.
2) When: After CETP and PLTP action, the TG-enriched HDL is a better substrate for HL.
3) Androgens: increase HL activity; thus, men often have lower HDL-cholesterol levels than women
Estogens: reduce HL activity, but the increase is minor compared to the increase in men from androgens.
1) What protein hydrolyzes HDL phospholipids?
2) What is the result of this hydrolysis?
3) Is this protein therefore atherogenic or atheroprotective?
4) What apoLP may inhibit this protein's activity?
1) Endothelial Lipase (EL)
2) Generates smaller HDL particles that are catabolized faster
3) Atherogenic. EL overexpression has been seen to reduce apoA-I and HDL-C levels to almost zero
4) ApoA-II may inhibit EL activity (HDL with ApoA-II are catabolized more slowly)
1) What is the function of Scavenger Receptor BI (SR-BI)?
2) Is SR-BI atherogenic or atheroprotective?
1) A major HDL receptor. It plays a critical role in maintaining plasma cholesterol levels and acts to deliver cholesterol to the adrenal cortex and gonads to support steroidogenesis.
2) Atheroprotective.
How does the transfer process of HDL components via SR-BI occur? What happens to the HDL after transfer?
-ONLY lipid is trasnferred to cells
-The entire HDL particle is NOT internalized
After transfer, HDL can recirculate to pick up more cholesterol
During HDL catabolism, how are apoA-I and apoA-II degraded? Where?
They are degraded synchronously, in the liver and kidney.
What enzyme initiates the conversion of cholesterol to bile acids?
cholesterol 7ɑ-hydroxylase
1) What is the fate of most bile acids?
2) What happens to the remainder of bile acids?
3) How is this important pharmacologically?
1) Most bile acids are reabsorbed, returned to the liver via the portal vein, and resecreted.
2) A small amount is lost in the stool, which provides a means of cholesterol elimination
3) Agents that bind bile salts and prevent their reabsorption are used to treat high blood cholesterol.
Name 4 regulatory mechanisms for the synthesis and transport of cholesterol.
1) Covalent modification of HMG-CoA reductase
2) Transcriptional regulation of HMG-CoA reductase gene
3) Activation of ACAT (increases esterification for storage)
4) Transcriptional regulation of the LDL Receptor
How do the following proteins affect the activity of HMG-CoA Reductase?
1) AMP-dependent protein kinase (AMPK)
2) Glucagon
3) Epinephrine
4) Insulin
Do they provide short or long-term regulation?
1) AMPK: phosphorylation, decreased activity
2) Glucagon: Cascades lead to phosphorylation, decreased activity
3) Epinephrine: Cascades lead to phosphorylation, decreased activity
4) Insulin: Cascades lead to dephosphorylation, increased activity
Covalent modification (phosphorylation) provides short-term regulation
1) What transcription factors control long-term regulation of HMG-CoA Reductase?
2) How are these transcription factors activated?
3) What other genes do these transcription factors upregulate?
1) Sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage activating protein (Scap, which inhibits SREBP)
2) High cellular sterol levels: Sterol-bound Scap binds SREBP in ER and holds it there
Low cellular sterol levels: Scap/SREBPcomplex cleaved, SREBP moves to nucleus and activates transcription
3) LDL Receptor, others
What sorts of feedback regulation of cholesterol synthesis and metabolism might you expect in a cell after it binds and internalizes an LDL particle?
- Decreased HMG-CoA activity
- Decreased LDL receptor expression
- Increased expression of storage enzymes


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Hanly Quarries - Concrete & Quarry Products
Quarry Products. Hanly Quarries Limited based at Laragan, Elphin, Co. Roscommon are the suppliers of choice for lime, aggregates, concrete and all grades .
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how to respond to 'do you eat dogs' asian stereotype?
53 Answers
- 9 months ago
just say that you only eat cats
- Log in to reply to the answers
- 9 months ago
I'd just walk away...so very rude
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- 9 months ago
The best way to respond to sarcasm is to ignore it.
- Log in to reply to the answers
- Alan HLv 79 months ago
Say, "Do not listen to people who tell you that nonsense "
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- What do you think of the answers? You can sign in to give your opinion on the answer.
- zipperLv 69 months ago
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- 9 months ago
Don't give them the time of day. Don't react they will stop once they see it dose not get a response any more
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- Suzy Suzy SueLv 69 months ago
Fvk off racist prick!
Edit: If it was a white guy, I'd ask: "Which Cousin did you end up marrying?!"
Haha, good one.
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- Donnie PorkoLv 79 months ago
No but I do eat kitties. Just ask your girlfriend. She was moaning with delight last night when I ate her kitty.
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- Anonymous9 months ago
I've been residing Expat Fashion on the other side of the planet up to my eyeballs in Asian Folk for nearly ten years.
And as often as I've turned on a TV & tuned-in to an English-speaking News-channel & observed the way things are playing out in the old-homeland I've almost as often considered putting on a Fake Accent & Pretending to be from Somewhere Else.
Not that it would do much good considering how Asian people are so typically inclined to "Stereotype" All Caucasian Foreign Nationals as 'Americans' anyway!
So, if That happens to be where you are, then I'm sure you're already aware that Most of even the Dumbest Americans typically Don't stereotype Asian-types as Dog-eaters though it's not unheard of for an occasional Dummy to stupidly Joke of it at the expense of somebody's feelings.
And since the U.S.A. is a big place even Dumb-As*es like That are Rare enough in even the Dumbest parts of the country, they're easy to avoid,
So your best "Response" to them is to just Hellooooo! AVOID DumbA*ses!
Witch BTW,,no-less typically exist hither & yawn & everywhere in Asian Cultures too,
since I've never lived in a mansion, Fu*ked a Supermodel, ridden a Harley Davidson, liked rap-music, been surfing at Malibu, Hung-out with Gay-friends, owned a new car, worn a Vagina for a Hat, called somebody the 'N-word', eaten at the Hard Rock Cafe or even Been to New York, gambled in Vegas, Don't have any Dogs in the fight (pun intended) so I couldn't care less who the frkn President is, never saw Elvis, Justin Bieber or Miley Cyrus in person and my name ain't JOE!
But since I come from humble beginnings & was raised with respectful manners, I know well enough how to slurp up a plate of Worms & even ask for seconds if that's what a Host is having for dinner.
Thus I never had a problem with gracefully cleaning my plate of the K-9 main course when perchance I happen to be a guest in some of the most humble of Asian homes.
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- strangerLv 79 months ago
Say maybe others do , but not me
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ALS to Henri Talon.
Durham, December 20, 1950. 2 pp. C. A. Allington, Dean of Durham; Henri Talon, author of John Bunyan: The Man and His Works. From a collection of letters and papers amassed by illustrator and painter Geoffrey Robinson during his years as a publisher with Rockliff, John Baker, Maclaren, et al. Item #05-1884
Price: $200.00
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Since 1994 the development of technology and establishment of commercialization bases are being conducted based on the national needs on long-ter..
The developed pilot mining robot, lifting system and integrated operation technology will be utilized for the pilot mining test in CCFZ claimed area. ..
2005. 12 Construction of Laboratory on Deep-Sea Mining Technology (LDMT)
2007. 07 Development of a prototype mining robot (1/20 of comme..


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Brevard High Seeks Funds To Restore Piano
More Than $21,000 Needed
June 13, 2019
For more than 40 years, the Brevard High School Chorus and Theater performances have been accompanied by beautiful music being created by many talented pianists and one piano. The singular piano is a Baldwin Grand piano manufactured in 1971. This instrument is in desperate need of restoration. The sound quality is suffering from worn keys, hammers, wippens, shanks and felts. Essentially, all the internal works of the piano need to be replaced. The case also needs to be refinished to restore it back to the beautiful instrument it was when originally put into service.
When asked about the piano and the need for the restoration effort, Charles Burchill, Brevard High's Chorus Director, shared the following:
"What I know about this piano is that it has been with BHS for most of its lifetime. In that time, it has been accessible to countless students and used in hundreds of concerts. In all that time, this piano has not had a major refurbishment, and the usual lifetime of a piano's soundboard is 50 years if it is well taken care of. Unfortunately, our piano does not fall into the well taken care of category.
"Although it is still a wonderful instrument, it needs a major restoration within the next couple of years in order for it to continue to serve our school and community. Brevard High School is looking toward the future now more than ever with its rebuild approved and being planned, and our arts programs are following suit. I would like for this piano to accompany us along our journey to becoming one of the best music programs in the state."
Keith Freeburg, of Freeburg Pianos in Hendersonville, evaluated the piano in April and provided the work scope and cost estimate for a complete restoration. Brevard resident Mark Lane, father of a current BHS Chorus member, started a GoFundMe effort to raise the $21,350 needed.
"I really hope more people in our community become interested in this effort and pitch in however they can to keep us progressing towards meeting this goal," said Lane. "I also hope that a strong show of public support may help in convincing the Tran-sylvania County School Board that this effort is worth allocating TCS funds to assist in achieving the goal."
To make a contribution, visit gofundme.com and search for "high-school-piano-restoration" (www.gofundme.com/high-school-piano-restoration). All donations to the campaign are transferred directly to an account managed by Transylvania County Schools.
For more information, Lane can be reached directly at (828) 553-0924.