text: 2020-07-11T21:52:39Z https://www.peertechz.com/oai-pmh oai:www.peertechz.com:10.17352/2455-2283.000059 2019-01-17 PTZ.ACG:VOL5 Unusual association of two rare entities: Primary rectal linitis and Klippel-Trenaunay syndrome Haraki I El Yazal S Ait Errami A Lairani FZ Jiddi S Samlani Z Krati KOubaha S<p>Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder, characterized by the triad of vascular malformations (angioma), venous and or lymphatic malformations and asymmetrical disturbed growth of soft tissues and/or bone. Primary rectal linitis is a rare digestive tumor with very poor prognosis. We report the case of a 41-year-old patient with Klippel trenaunay syndrome who was diagnosed with primary rectal linitis. </p> Archives of Clinical Gastroenterology - Peertechz Publications 2019-01-17 Case Report https://doi.org/10.17352/2455-2283.000059 en Copyright © Haraki I et al.


text:
China: riding the dragon
This year, China's GDP is forecast to grow at the slowest rate for over a decade. However, the country is set to be remain the global growth engine, presenting huge opportunities for food companies. There are, however, myriad challenges to navigate.
China briefing: The "sleeping dragon" awakened 29 Nov 2013
After three decades of double-digit growth, fuelled by high levels of export and investment, China's economy has seen something of a slowdown. The country is facing a number of structural issues as it progresses from a manufacturing-led economy to one underpinned by services and consumer spending. Nevertheless, the underlying drivers of consumption remain and the government seems well-prepared to manage this transition. For the foreseeable future, China looks set to remain the global growth engine. Katy Askew reports.
China briefing: Retailers look to China for growth opportunities 29 Nov 2013
China's grocery market has been growing at a rapid pace for several years. Representing one fifth of the world's population, this emerging market has become a significant opportunity for foreign investors seeking overseas growth. Michelle Russell reports.
China briefing: Beijing puts wheels in motion on new safety laws 29 Nov 2013
The Chinese government has published a draft of proposed changes to the country's laws governing food safety. Companies operating in China may need to make significant changes to how their supply chains and distribution networks. David Green in Beijing reports.
China briefing: Multinationals face shifting formula landscape 29 Nov 2013
Multinational companies have dominated China's infant formula market but domestic companies are, with government support, looking to bolster their position with demand expected to remain buoyant. Wang Fangqing in Shanghai reports.
China briefing: Multinationals vie for place at table 29 Nov 2013
With an increasingly affluent population of more than 1.36bn mouths to feed the potential offered by China's food sector is immense. But the size of the opportunity does not, in itself, guarantee success. Competition is fierce as multinational food groups and local players alike look to grow their share of this vast pie. Katy Askew examines the competitive dynamics of the Chinese food sector.
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subset: commoncrawl


text:
Post Falls man died in raceway accident
Tue., May 12, 2009
A contractor killed in an accident Friday at the Spokane County Raceway was identified Monday as Bob L. Arndt, of Post Falls.
Arndt, 68, owned Quality Maintenance, a company that specializes in parking lot work, according to a Web site listing.
The Spokane County medical examiner performed an autopsy Monday morning on Arndt and ruled that he died of multiple fractures and trauma in an accident.
Arndt was talking with the track's general manager when an Infiniti sports car spun out of control, striking him near a curve in the track's 2 1/2-mile road course.
A 46-year-old retired military pilot taking laps in his Infiniti G30 struck Arndt at the south end of the track, sheriff's deputies said last week. The driver's name was not released.
The victim was thrown 15 feet and hit a tree.
Services for Arndt are set for 1 p.m. Thursday at English Funeral Chapel, 1700 N. Spokane St., Post Falls, with additional services to follow at Evergreen Cemetery.
A voice message on the business answering machine acknowledged Arndt's death and indicated that the company, which started in 1987, was working to deal with his loss.
The county purchased the raceway property last year and turned it over to Austin Motor Sports Management, owned by Tacoma businessman Bucky Austin, also the owner of Bucky's Complete Auto Repair.
Arndt was working on track improvements Friday. He was talking with track manager Jay Livingston about where to paint lines on the track surface.
About 30 sports car drivers of various ages were at the track running practice laps. Some were from out of the area.
The raceway's events calendar indicates the track was leased to Scott Adare Motorsports. According to Adare's Web site, the company sponsors experienced track drivers who bring their own vehicles to drive on the track one Friday a month.
Attempts to contact Livingston and Adare were unsuccessful.
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text:
Original CATERPILLAR Dealers Service Repair Shop Manuals for the 768B Wheel Tractors, the 769B Quarry Dump Trucks and the 1693 Diesel Truck Engines. Serial Numbers shown on binder are 35W1-up, 79S1-up and 99F2413-up. It comes in an original CATERPILLAR 3-Ring Binder. This manual has detailed repair information with lots of pictures. The same genuine CATERPILLAR manual your dealer used.It's divided into sections covering. NOTE: Many used Caterpillar Service Manuals have forms missing.
If our manuals have any missing forms, we state that in our listings. Please see below if any information in this manual is missing.This manual is missing tab dividers & Testing & Adjusting Torque Divider & Range Transmission (form 1689). INCLUDED IN THIS MANUAL IS AN EXTRA BOOK TITLED " 1693 DIESEL ENGINE TRUCK SERVICE MANUAL " - SEBR0505. We will not sell the homemade & often illegally copied reprints & cd's. THIS IS AN ORIGINAL CATERPILLAR MANUAL! If you are interested in Tractors & Farm or Construction Equipment, please check out my other auctions!
The item "Caterpillar Cat 768B Tractor 769B Truck & 1693 Dsl Engine Service Repair Manuals" is in sale since Friday, August 5, 2016. This item is in the category "Business & Industrial\Heavy Equipment, Parts & Attachments\Heavy Equipment Parts & Accessories\Heavy Equipment Manuals & Books". The seller is "beyertractor" and is located in Elizabeth, Illinois. This item can be shipped worldwide.


text:
This Advanced Systems & Designs - ASDQMS SmartCable™ USB Keyboard single gage interface connects the A&D MC Series Mass Comparator Balance to a computer. Attaches the A&D MC Series Mass Comparator Balance to the SmartCable Keyboard gage interface using a 25-pin male cable connector---no additional cables required. The output of the ASDQMS SmartCable Keyboard is a standard USB 2.0 keyboard signal.
Connecting the ASDQMS SmartCable USB Keyboard gage interface with its built-in keyboard wedge to a computer will allow the A&D MC Series Mass Comparator Balance to be identified as a keyboard device that can send data to any Microsoft Windows application - no software wedge required. This SmartCable Keyboard will make the A&D MC Series Mass Comparator Balance readings appear as if they were typed in using a standard keyboard - eliminates data collection errors. If you want to collect data into a Microsoft Excel spreadsheet, simply select the cell where you want the data to appear and trigger a reading.
Pressing a ENTER key on the A&D MC Series Mass Comparator Balance
Pressing the button on the ASDQMS SmartCable™ Keyboard gage interface
Depressing a connected footswitch (not included)
A detailed operation manual is included with this Advanced Systems and Designs SmartCable Keyboard gage interface. At the factory, Advanced Systems & Designs normally sets the SmartCable Keyboard to the default settings on the A&D MC Series Mass Comparator Balance. Make sure both the SmartCable and A&D Mass Comparator Balance are set to the same values. Refer to the A&D MC Series Mass Comparator Balance instruction manual for more information on connecting the serial interface to a computer.
LED Indicator lights aid the user with the operation of the SmartCable Keyboard gage interface. This ASDQMS SmartCable Keyboard gage interface is easily configured to output data in different output modes on your spreadsheet, such as CR, TAB, up, down, left, or right. The output mode is selected by adjusting the rotary switch on the SmartCable Keyboard. To access the rotary switch, simply remove the top cover by loosening two Phillips screws.
Six foot standard cable length. Special lengths are available upon request.
ASDQMS SmartCable™ Keyboard gage interface for A&D MC Series Mass Comparator Balance
Sends data to Excel or other Explorer based SPC programs
Multiple data triggering options
Special cable lengths available on request
Lifetime warranty against manufacturing defects


text:
NEW 22" Smart TV
- Android 6.0.1 OS
- Frameless design for full screen viewing
- Built-in DVB-S2 Freeview Satellite Receiver
- Built-in DVB-T Freeview Receiver
- Single Tuner PVR (USB Record)
- Wireless Audio Technology with Bluetooth
- DVD with Multi Media Centre
- Digital Radio
- Full 1080 Screen
Designed and Manufactured under the umbrella of the ISO 14001 Environmental Management Certification
12v/24v DC & 230v AC
- Anti-glare Screen
- Anti-shock / Anti-vibrate
- 2 year warranty
All Freeview Channels pre-loaded in order.
*Please note: This device is not currently compatible with TVNZ On Demand, Three Now or Spark Sport*
This version comes with a Double Sided Air Mouse Remote included with the TV. This helps to navigate through your Smart TV easier.
- Power Input: DC 12V and 24V
- Power Consumption: 30 watts (2.5 amps)
- Dimensions: 489W x 313H (on stand) 295H (without stand) x 48D mm
- Weight: 3Kg (exc. Stand)
- 1 x Mini AV In, 1 x Earphone Jack, 1 x DVB-S2, 1 x DVB-T, 2 x HDMI, 1 x USB PVR, 2 x Android USB, 1 x Ethernet. Audio Out.


text:
Last Friday evening I meet my friend and fellow CIGA guide at the V&A to see the exhibiton about the golden age of sea travel.
That's on a boat!
Heaven, I'm in heaven...
Check out the compact tea set, a leather clutch bag shaped like a liner, and some gorgeous fabric – the wonderful typographic pattern on a silk blouse and a late-1960s blue suit deemed unconventional/'unsuitable'.
I love the V&A (well, apart from this) – there is always something new to see and, more often than not, it's been there for decades and I just never noticed before.
The V&A is open late on Fridays. That's great for people who can't get there during the day and don't like having to fight with school groups or weekend families. But not so great is the type of music that's played there which seems to pull in a new crowd of bar-goers who hang around the reception desk at the Brompton Rd entrance in front of huge speakers on sticks which blare out bass-heavy rhythms. I reckon most of them don't even wander further than the gift shop. Or perhaps that's the point.
We found the sound levels offensive and hard to dodge as the only way in and out is past that desk (or it was by the time we were leaving). It was a horrible contrast to the swooning tunes of the 1930s.
The type of sound is just wrong for the environment – boom boom boom! It reverberates and resonates with nasty low-level frequencies around the curves of this beautiful building like some kind of migraine. Music is great but, please V&A, keep it acoustic next time. Guitars, strings, pianos, even brass – but not anything amplified. Thanks for listening!
And before anyone starts calling me old and grumpy – I would've said all that when I was 20.
Come and see some Art Deco architecture in North London on my guided walks
Culture Magazine
Ocean Liners: Speed and Style at the V&ABy Janeslondon
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text:
Question about 1987 Volvo 240
Volvo 240 dl 1987 .. driving down the road, car starts to stutter. Keep accelerating and its hesitating. (almost as if you would put foot on the accelerator and quickly letting off, Repeatedly)....Then car dies.
Attempt to keep restarting it and it just dies. Its turning over, but sputtering. Like its starved for gas. We sit there a few minutes (prob about 10 mins) it cranks right up, drives about 1/2 mile and stalls out again. We let it sit, and it will crank right up and drive ok again for a little while, then die out again. Like its overheating (although temp thing reads fine). Car has run flawless for long time,never any issue like this. All the sudden on MUGGY HOT day (high 90's and very humid) starts with this problem out of the blue. (although we have very many hot muggy days here in NC).
Each time after sitting, the car will crank right up and drive a little ways, then sputter and stop again. Seemingly getting too hot, and starving for gas. Any ideas? We thought the fuel filter, friend says it IS getting fire, but he's not sure what it is. After it sat for about an hour, he was able to drive it up to the store and back with no issues whatsoever. So I'm confused.
any help would be appreciated.
Posted by jennerina on
Got in it this morning...cranked right up. No hesitation, no clunking, put in drive, went to walmart, came back, not even one issue. CONFUSED!!
SOURCE: 89 volvo 240 dl wagon stalls and will not even turnover
A dead 7 mos battery is not getting re-charged properly. If alt is ok then it must be wires/connections. Sudden death while driving could be related to bad battery condition - thus the reprieve when turning off and starting over. I would have a real volt meter ( not just dash) attached to this car for a while so that I could see what is going on while driving.
Posted on Dec 31, 2008
SOURCE: My volvo 240 DL Station
check m.a.p. sencer on air inlet check if plug is loose could be
o2 sencer bad sending false info to comp. check if it has code at self check
Posted on Jan 01, 2009
SOURCE: 89 volvo 240 dl wagon stalls and will not even turnover
If you can get it running again, get it to an electrical shop where they can test the charging system. If the alternator is still bad, it will continue draining the battery. If it won't run, pull the alternator and take it to a shop that can test it.
Posted on Jan 25, 2009
SOURCE: 2002 Volvo V70 T5 -
If you look at your engine you will a silver fuel rail just at the front of the cylinder head. follow the rail to the air filter box side and you should see a blue cap on what looks like a schrader valve (if the cap is still there). unscrew the blue cap and carefully push in on the schrader valve, if the fuel system is ok there should be a good amount of fuel pressure and fuel will shoot out so be careful.
If there is no fuel that comes out and you've already replaced the pump and filter I don't have a whole lot for you. If there is fuel then I would call your Volvo dealer and see if your car has the extended warranty on the Electronic Throttle Module (ETM). Volvo extended the warranty for 10 yrs or 200,000 miles.
It could be a host of other things, but the ETM's are known to be prone to build up on the throttle blade and sometimes failure. There is also a very good software upgrade they can do to help the operation of the ETM's. I'm hoping your in the U.S.
There was a recall campaign 155 that was specifically for the ETM's
Hope this helps..
Posted on Feb 23, 2009
SOURCE: 88 volvo 240 starts most of the time but dies when i push gas
Wow. any number of things. Clogged fuel filter? Fuel pump relay. Try getting in the car when it's quiet around you. Turn the key to "on", not start. You should hear the fuel pumps hum for a few seconds and then stop. If you don't hear them, check your fuse box. They are labeled but I believe #6 is usually the main fuel pump fuse. If fuses are good, then it could be your fuel pump relay. These typically develop cracks in the solder and when they warm up, break contact and theengine dies. The relay is accessed by removing the 7 screws that hold your glovebox in. Slide it out as a unit. Remove the glove box bulb if you're going to be at it any great length of time or your battery will die. The relay is a white rectangular box clipped to a metal frame on the left of the now exposed innards. It has like 6-8 pins. Thump it a couple of times and see if the car will start. If it does, replacethe relay. Order online as much cheaper than dealership.
If you do hear the pumps cycle when you turn the key to on, then most likely you have a bad ignition module. Your '88 has LH2.2 so there is no crank sensor to go bad. The ignition module is mounted to the driver's side under hood by air cleaner. Small flat black rectangle w/ silver metal base.
If all this is Greek to you, try a Volvo specific forum like swedespeed.com
Posted on Apr 21, 2009
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text: Well, it looks like even the pro's can take a Monday Mishap style back edge! This one was submitted by Steel Lafferty. Looks like he recorded a computer screen with his phone of some allegedly "deleted" footage from a handheld camera inside the boat. This might be the worst quality footage you will ever see of Steel. Regardless, enjoy Steel's heelside backside off-axis 810. Enjoy!


text:
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text:
Positive cyclin T expression as a favorable prognostic factor in treating gastric gastrointestinal stromal tumors
- Authors:
Affiliations: Division of Gastroenterology, Department of Internal Medicine, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan R.O.C., Department of Pathology, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan R.O.C., Department of Applied Chemistry, National Chia-Yi University, Chia‑Yi 600, Taiwan R.O.C., Center of Nano Bio‑Detection, National Chung Cheng University Chia‑Yi, Chia‑Yi 621, Taiwan R.O.C.
- Published online on: March 30, 2016 https://doi.org/10.3892/mco.2016.835
- Pages: 971-975
This article is mentioned in:
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and mesenchymal tumors are thought to constitute ~1% of primary gastrointestinal cancers (1,2). Between 50–70% of GISTs arise from the stomach, which is the most common site of origin (1,3). The National Institutes of Health (NIH) 2002 consensus stratified GIST risk according to tumor size and mitotic rate (3). It has been proposed that these stratification guidelines should be widely used to predict recurrent risk factors, and modifications have also been proposed (4); however, certain factors regarding the criteria remain to be elucidated, such as the impact of tumor location, which may lead to an overestimation of the risk of large gastric GISTs (5,6). Another risk stratification schema that incorporates the impact of tumor location has been supported by three large retrospective studies conducted by the Armed Forced Institute of Pathology (7–9). However, some questions remain regarding the rare clinical settings that lack proposed parameters of risk assessment, as the data was too insufficient to lead to a convincing definition (5,6). Therefore, finding a reliable immunohistochemical predictor would be helpful for clinical practice.
Positive transcriptional elongation factor b (P-TEFb) contains the catalytic subunit cyclin-dependent kinase 9 (Cdk9) and the regulatory subunit cyclin T. Cyclin T contains subunits T1, T2a and T2b. Cdk9 is complexed with T1, T2a and T2b in ~80, 10 and 10% of cases, respectively (10–12). The expression pattern of cyclin T2a almost completely overlapped the pattern described for cyclin T1 (12). The expression of cyclin T1 increased the Cdk9 kinase activity and the phosphorylation of RNA polymerase II (RNAPII). The hypophosphorylation of the carboxyl-terminal repeat domain of RNAPII promotes and starts the elongation phase of transcription (13). This enables RNAPII to escape promoter-proximal pausing in order to engage the factors for pre-mRNA processing (14).
P-TEFb has been proficiently investigated in cardiac hypertrophy and human immunodeficiency virus (HIV) infection. The transcriptional activation for HIV-1 requires Tat interaction with human cyclin T1 and involves the formation of a complex with P-TEFb to increase the amount of RNAPII (15). In addition, the Cdk inhibitor, flavopiridol, has been reported to have a mitigating effect on RNAPII levels (16). By contrast, hypertrophic signals may activate Cdk9 and consequently cause phosphorylation of RNAPII. This effect not only increases RNA synthesis but also enlarges myocyte size and may result in cardiac hypertrophy (13,14). In previous years, certain studies have reported that P-TEFb and transcriptional elongation exhibited key roles in protecting normal and cancerous cells from apoptosis (17). Cdk9 inhibitors have been thought to be potential therapeutic agents for chronic lymphocytic leukemia (18) and lung adenocarcinoma (19). Cyclin T1 and Cdk9 are also overexpressed in the human head and neck carcinoma cell lines (10).
The expression of cyclins A, B, D and E appear to be associated with high-grade disease but not with the clinical outcome (20–22). In addition, cyclin H-positive patients have a poor prognosis when they have high-risk GIST and when they exhibit metastasis or recurrent disease (23). However, there are few effective clinical predictors for gastric GIST. The aim of the present study was to assess the association of cyclin T1 and Cdk9, and the clinical parameters of gastric GISTs.
Materials and methods
Tissues and patients
The study included 30 gastric GIST patients who underwent either laparoscopic or laparotomic partial gastrectomy between 2008 and 2011 by the same surgical team at Tungs' Taichung MetroHarbor Hospital (Taiwan, China). Fifteen of the patients who were at a high risk of recurrence according to the NIH consensus received postoperative adjuvant chemotherapy with imatinib, and 1 patient received sunitinib. The medical charts, pathological reports, and surgical notes of all the study participants were retrospectively reviewed. The pathological diagnoses were reviewed by at least two experienced pathologists.
Ethics statement
The study was granted approval from the Institutional Review Board of the Tungs' Taichung MetroHarbor Hospital. All the patients included in the study received a full explanation of the procedures involved and provided written informed consent prior to collection of the specimens and clinical information.
Immunohistochemical staining
Using the Bond-Max autostainer (Leica Microsystems, Buffalo Grove, IL, USA), the slides were stained with Cdk9 monoclonal antibody and cyclin T1 polyclonal antibody. The details of these immunomarkers, including methods of pretreatment for antigen retrieval, are provided in Table I. Briefly, formalin-fixed and paraffin-embedded tissue specimens were placed in Tris-buffered saline and Tween 20, rehydrated through serial dilutions of alcohol, and washed in phosphate-buffered saline (pH 7.2), which was the buffer that was used for all subsequent washes, according to the manufacturer's recommended protocol. The coated slides were stained with the previously mentioned antibodies, and the immunostaining procedure was performed on the fully-automated Bond-Max system using the onboard heat-induced antigen retrieval and a Leica Refine Polymer Detection System (Leica Microsystems). Diaminobenzidine was used as the chromogen (Leica Microsystems) in all these immunostainings. Negative controls were obtained by excluding the primary antibody. Appropriate positive controls were used throughout the study. These slides were mounted with gum for microscopic examination, and the images were captured by the Olympus BX51 microscopic/DP71 Digital Camera System (Olympus, Ina, Japan) for study comparisons.
For the assessment of Cdk9 and cyclin T1 expression, the intensity of immunostaining was scored on a scale of 0 (no staining) to 4 (strongest intensity), and the percentage of cell staining at each intensity was estimated from 0 to 100. The percentage of cells at each intensity level was multiplied by the corresponding intensity value, and these products were combined to obtain an immunostaining score ranging from 0 to 400.
Statistical analysis
The disease-free survival (DFS) rates of patients were analyzed by Kaplan-Meier estimates and compared using the log-rank test. The DFS was defined as the interval between the date of surgery and the date of tumor recurrence or distant metastasis. Cox regression methods were used to investigate the association between survival, clinical parameters and immunohistochemical variables in multivariate models. Differences between positive and negative cyclin T1 staining were analyzed using the Mann-Whitney U-test. All the statistical tests were two-sided. The difference between the groups was considered statistically significant when P<0.05. All the analyses were performed using the SPSS 16.0 (SPSS, Inc., Chicago, IL, USA) software package.
Patient variables
A total of 30 patients were examined in the study (15 male and 15 female). The mean age was 60.3 years; 14 patients were <60 years old and 16 were >60. Eleven patients developed tumor recurrence or distant metastases during the study. Fifteen of the patients who were at high risk of recurrence according to the NIH consensus received postoperative adjuvant chemotherapy with imatinib, and 1 patient received sunitinib. The other 14 patients did not receive postoperative adjuvant chemotherapy. The scores of Ki67 staining for 6 and 8 patients were > and <5%, respectively. The results of the other 16 patients were not recorded.
Ten patients were cyclin T1-positive (Fig. 1), and 20 were negative. All 11 patients with recurrent tumors or distant metastases were cyclin T1-negative patients. The DFS was analyzed using univariate log-rank test and multivariate stepwise Cox-regression test. Old age, large tumor size, higher Ki67 staining, high mitotic count and negative cyclin T1 staining were associated with clinical outcomes in univariate analysis. The Kaplan-Meier survival curve illustrated the DFS of the patients with negative cyclin T1 staining was significantly lower than that of the patients with positive cyclin T1 staining (P=0.031, Fig. 2). However, no significant difference was observed in the DFS between different ages, genders, tumor size, pathological type, Ki67 staining and cyclin T1 staining using the multivariate analysis. The clinicopathological features and univariate and multivariate analyses are summarized in Table II.
Figure 2.
Kaplan-Meier survival curve of patients with gastrointestinal stromal tumors with negative or positive cyclin T1 staining. Patients with positive staining for cyclin T1 (n=30) showed a significantly good disease-free survival rate (P=0.031).
Table II.
Univariate log-rank and multivariate Cox analyses for prognostic factors with respect to disease-free survival.
Subgroup analysis for cyclin T1
The patients were also divided into two subgroups on the basis of positive and negative staining for cyclin T1. Cyclin T1 staining was analyzed with the other clinicopathological factors. No significant differences were observed between the two subgroups. However, patients with negative cyclin T1 staining appeared to have poorer results than those with positive cyclin T1 staining. Among the 30 patients, 23 patients had low mitotic rates, and 7 had high rates. All 7 patients with high mitotic rates were cyclin T1-negative. A summary of the association between cyclin T1 staining and other clinicopathological factors are shown in Table III.
In the present study, age, tumor size, percentage of Ki-67 staining, mitotic rate and cyclin T1 staining were the prognostic factors associated with recurrence in patients with gastric GIST following surgical resection. The results showed a significant difference in the univariate analysis but not in the multivariate analysis. Along with the factors of large tumor size and high mitotic rate presented in the NIH consensus, several studies have defined other poor prognostic factors, such as epithelioid type, increased expression of cytoplasmic HuR and cyclin A, and a high Ki67 ratio (24–27). Increased expression of cyclin H was also a poor prognostic factor in high-risk GIST patients (23). The present results showed that cyclin T1 may be another potential prognostic predictor for gastric GIST patients.
The association between cyclin T1 staining and other factors was also analyzed. Although no statistical significance was observed in the difference in mitotic rates between the cyclin T1-positive and -negative patients, all 10 patients with positive cyclin T1 staining had low mitotic rates, and all 7 patients with high mitotic rates were negative for cyclin T1. Cyclin T1 may be a potential regulator of mitosis and may contribute to tumor recurrence.
In a previous study, Cdk9/cyclin T1 complex upregulation contributed to T lymphocyte differentiation and malignant transformation (28). Regulation of the Cdk9/cyclin T1 complex is dependent on a tissue-specific signaling pathway (29), and the complex response to certain cytokines such as tumor necrosis factor and interleukin-6 (30,31). Cyclin T1 and Cdk9 may promote the expression of anti-apoptotic factors and cause proliferation (32–34). A deregulated Cdk9-related pathway has been observed in several human tumors, including lymphoma (29,35,36), neuroblastoma (37), prostate cancer (38) and several hematopoietic malignancies (29). By contrast, certain studies have demonstrated that cyclin T1, but not Cdk9, induced transformation in vitro in head and neck tumors (10). Upregulation of cyclin T1 is the main mechanism for activation of the complex during T-cell activation, and cyclin T1 acts as a rate-limiting regulatory subunit (39). A previous study also suggested that the cyclin-dependent kinase inhibitor had no correlation with the malignant potential of GIST and did not serve as a predictor of DFS (40). The present results demonstrated that cyclin T1, but not Cdk9, was a prognostic factor for DFS, and that cyclin T1 was associated with the mitotic rate. The study confirmed that cyclin T1 has a regulatory role in the Cdk9/cyclin T complex, and that upregulation of cyclin T1 was the main mechanism for the activation of this complex. These results also supported that cyclin T1 acted as a rate-limited regulatory subunit (39).
Certain previous studies have shown that cyclin T1 overexpression was a poor prognostic factor (10,28,29,39). However, the present results demonstrated that negative staining for cyclin T1 was a poor prognostic factor. Cdk9 and cyclin T1 were expressed in a similar pattern in certain normal tissues, but varied in other tissues (12). The tissues of mesenchymal organs, such as connective tissue, skeletal muscle, blood and lymphoid tissue, exhibited high cyclin T1 expression levels (11,12). It is also believed that cyclin T1 is not a typical cell cycle regulator, as its levels do not oscillate at any phase during the cell cycle (11). Additionally, the upregulation of cyclin T1 is not linked directly to cell cycle entry and progression (11). In different tissues, the expression of cyclin T1 has different roles in tumor behavior. Deregulation of cyclin T1 contributes to poor outcomes, and negative cyclin T1 expression is potentially associated with a worse prognosis.
The present study had several limitations. The subgroups of patients were too small for individual analysis. A study with a larger sample size will be necessary for further investigation of the predictors of gastric GISTs. In addition, in vitro cell molecular studies would help to identify the pathway of cyclin T1. This was a pilot study to determine whether cyclin T1 could be considered for further studies including more patients and cell lines to confirm the role of the Cdk9/cyclin T1 complex in GIST.
In conclusion, it is reasonable to consider cyclin T1 immunohistochemical staining as a predictor of the prognosis of gastric GIST following surgical resection. The pathway of cyclin T1 was also demonstrated to potentially be associated with the mitotic rate.
The present study was supported by a grant from Tungs' Taichung MetroHarbor Hospital (no. TTMHH-100R0004).
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Date and Time
Saturday Nov 2, 2019
Saturday, November 2, 2019
5:30pm to 11:00pm
Scottish Rite Cathedral
400 NE Perry Avenue
Peoria, IL 61603
Two tickets to the Art Gala: $175.00 Single ticket to the Art Gala: $100 For more information on admission, or for sponsorship information, please visit our website: https://rmhc-centralillinois.org/art-gala-peoria-house-event-registration/
Contact Information
Please contact Kelly Thompson, CEO of Ronald McDonald House Charities of Central Illinois, at 309-401-2525.
Send Email
Join us on Saturday, November 2, at the Scottish Rite Cathedral in Peoria as we "Bid to Give" for the new Peoria Ronald McDonald House®. This is an evening you don't want to miss and is sure to be the talk of town. Live art demonstrations, pop-up entertainment, great food, and a cash bar will make for a fun evening. Plus, you'll get to meet some talented regional artists and see the original art we've selected for the Peoria Ronald McDonald House. The Art Gala features over 100 original artworks created by dozens of regional artists. Award-winning Ronald McDonald House Charities Artist of the Year, Jeff Hanson, will also be at the event. His work will be among the art featured in our LIVE "Bid to Give" auction. Jeff has pledged to help raise $10 million for charity by the time he is 30! Individuals, couples, families, friends or businesses can select and sponsor one or more artworks or make a gift to help us purchase the works. Each individual or group will be recognized for the thoughtful gift of art with a plaque displayed next to your sponsored piece(s). "We love these works and know they will brighten the lives of those who will be staying at the Peoria Ronald McDonald House®. Each work has been chosen to create a fun, healing environment for the children, their families, and all who will care for them." ~~ Art Gala Committee


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The best cult TV shows to watch right now
You may not be familiar with these brilliant cult shows, but their passionate fan followings speak to their uniqueness.
Tired of watching blockbuster movies featuring superheroes and alien invasions? Sundance Now provides a great alternative to mainstream entertainment. The streaming service prides itself on offering subscribers access to independent flicks and TV series that are hard to find anywhere else, with a focus on festival hits and some original programming.
In other words, it's the perfect platform for those who like to discover hidden gems and tune in for shows or movies not everyone is watching.
Owned by AMC Networks, Sundance Now takes its name from the famed Sundance Film Festival, the largest independent film festival in the United States. The service launched in the US back in 2014, aiming to bring the festival's spirit to the home viewer. Besides independent movies, it began offering TV shows and documentaries as well, catering to a wider audience. On the same note, the service entered the original programming game, striving to develop series and films that would appeal to lovers of independent cinema.
Currently, Sundance Now is available in the US, Canada and Ireland.
Sundance Now was originally slated for launch in Australia by the end of 2018, but that time has come and gone without so much as an update from AMC. Currently, it's unclear when or even if Sundance Now will open up its library to Aussie movie buffs.
In the United States, Sundance Now costs US$6.99/month or US$59.99 for a yearly membership. In Canada and Ireland, the price is adjusted to reflect local currency. Hence, we expect the monthly fee to remain the same for Australia as well.
If the price stays the same, that would make Sundance Now a tad more affordable than Netflix, Stan or Foxtel Now – which would make sense, since the content is more niche. The platform offers a seven-day free trial, so Aussie users will likely be able to test-drive it and browse the library for free to decide if it's worth the investment.
Sundance Now's library is pretty diverse, ranging from acclaimed independent films to provocative documentaries and binge-worthy series. However, it's possible than not all titles from the US library will be available in Australia due to licensing arrangements. We'll just have to wait and see.
To give you a taste of what's in store, though, Sundance Now's exclusive series include titles like Killing for Love, One Deadly Weekend in America, Motherland and The Swell. The TV show offering is limited, due to the platform's focus on films and documentaries, but there are several original productions that are worth the binge.
You may not be familiar with these brilliant cult shows, but their passionate fan followings speak to their uniqueness.
Riviera, for instance, is an addictive show starring Julia Stiles as a young widow who sets out to investigate the circumstances surrounding her husband's mysterious death. This Close follows two deaf friends who rely on each other to navigate life, while The Bureau is an explosive French-language series centring on a kidnapped special agent. As you can see, your choices may be limited, but they cater to a wide range of tastes.
As far as documentaries are concerned, you won't run out of content to watch anytime soon. You can browse by categories, including Art & Culture, Biography, Travel & Adventure, or Sports. Popular titles include Taxi to the Dark Side, an investigation into the reckless abuse of power by the Bush Administration; Cousin Bobby, focusing on a minister who fights tirelessly to improve the lives of people of colour; and Gaza Surf Club, about amateur surfers in the Palestinian Gaza Strip.
Finally, there are hundreds of films available on the platform, ranging from festival darlings to classics. The titles that caught our eye include Amour, Heathers, Frances Ha, Tideland, Aferim!, Dogtooth, Boyhood and Hello I Must Be Going. However, plenty more are available on Sundance Now, enough to last you for a few movie marathons at least. A great thing about the service is that it offers Collections, making it easy for users to discover new series, movies or documentaries. With names like Provocative Thinkers or Justice for All, these collections are a good place to start if you're new to the world of independent cinema. You can also browse Collections to see what the likes of Susan Sarandon and Danny Glover recommend you stream on Sundance Now.
If you're looking for something to watch until Sundance Now's Australia launch, you'll be happy to know that each streaming service on the market offers a small selection of indie titles. We've rounded up all the independent films on Netflix into one convenient list, if you want to check those out. Alternatively, Foxtel Now offers cult classics like The Blair Witch Project, The Boat That Rocked, Little Miss Sunshine and The Virgin Suicides, among others.
Over on Stan, you can stream The Perks of Being a Wallflower, Eternal Sunshine of the Spotless Mind, Blue Velvet or Clerks. Finally, Amazon Prime Video offers titles like Dazed and Confused and Night of the Living Dead.
As you can see, there's enough to get you started. But if you're planning to expand your knowledge of independent movies, you'll have to check out what Sundance Now has in store. Hopefully, the wait won't be excruciating.
Telstra TV Box Office lets you rent or purchase the latest blockbusters straight from the cinema. Read more…
The fourth instalment of the Jurassic Park film series is a visual treat. Read more…
Settle in for the Joker's chilling origin story. Read more…
Getting home can be the greatest adventure. Read more…
This delightful sequel is just as charming as the original. Read more…
Tune in for an explosive confrontation a long time in the making. Read more…
You don't get to 500 million friends without making a few enemies. Read more…
A powerful performance from Blake Lively makes this thriller a must-see. Read more…
Will Ferrell and Kevin Hart headline this raunchy comedy about preparing for the worst. Read more…
San Andreas is a thrilling disaster movie that genre fans will love. Read more…
Based on the hit 1980s TV action/drama, the Miami Vice movie is a stylish crime drama about undercover cops. Read more…
Two renowned paranormal investigators are caught up in the most horrifying case of their lives. Read more…
All the biggest shows and movies from HBO and more on-demand.
Sample all the best of British TV.
Try Amazon Prime Video's huge library for 30 days free.
Binge thousands of reality TV shows with 30 days free.
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The secret to fluency is daily conversation practice. You have tried apps that mostly let you type answers, click on pictures or repeat sentences. You have tried watching videos where someone else was doing all the talking. This is the slow way. Using the language in a conversation every single day is the fast way to fluency. Our virtual conversation sessions provide the speaking practice that leads to real fluency.
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You'll love practising your conversations out loud with your virtual practice partner. The videos will be about 2 or 3 minutes and will give you an opportunity to participate in a fluency-building conversation every single day.
Do you believe that practicing 365 conversations would improve your speaking skills? Of course it would! By putting in a few minutes a day, you will bit-by-bit increase the amount of talking that you're doing and see the results in your confidence and level of fluency.
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- Paliwal had admitted her aspiration to be an avid biker to her father while she was still young. She shared in an interview to Jaipur Women Blog
- She had learned how to ride a bike from her friends in college, as she didn't own a bike herself, she couldn't pursue her passion back then
- A resident of Jaipur, the 44-year-old bike enthusiast was named the Lady of Harley (Dunes Harley-Davidson)
- Paliwal was married. But she ended the marriage to pursue her passion for biking as her husband was against her bike riding
- She owned a Victorian tea room lounge in Jaipur named Chah Bar
- She dreamt of joining politics someday to spread awareness about safety measures for driving and bike riding.
- Paliwal planned to document her motorbike journey across the country.
Apr 13, 2016
RIP Veenu Paliwal - 7 Things About the Indian Female Biker You'd Love To Know
Veenu Paliwal (44) one of the leading women motorcyclists of India, met a tragic end en route Bhopal when her bike skid off the road near MP's Vidisha district. Let's know a little about this daredevil:


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France first expects reactions to the non-paper from all EU member states, but will also attentively listen to the remarks from the Macedonian side as well, French Ambassador Christian Thimonier said on Monday, answering a journalist question after meeting with Constitutional Court President Sali Murati.
The French non-paper, dedicated to the new methodology in the negotiation process, as Thimonier pointed out, has already been delivered to all EU member states, and following the instructions that the French ambassador received from the French government, the document has also been delivered to the Macedonian government.
In fact, these are the French opinions sent to all EU member states and I have delivered them to the Macedonian authorities following the instructions of my Government and we expect the reactions of the member states first, but we will also be very careful and hear the remarks from the Macedonian side, said Thimonier.
He announced that he would meet Monday with Deputy Prime Minister in charge of European Affairs Bujar Osmani, who he said would hear about his thoughts on the French document, and announced meetings with other officials in the country.
However, Thimonier pointed out, the most important thing is respect and functioning of the rule of law and added that it is a matter that everyone agrees on.


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The first 500 who click the link will get 2 free months of Premium Skillshare and explore your creativity https://skl.sh/makersmuse
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The Best Locations To Find Ghosts In 'Ghostbusters World'
Ghostbusters World has us all ready to gear up and rush out to fight any and all ghosts! The new AR mobile game allows the world of Ghostbusters to come to life and find ghosts that came from the original series or even brand new spooky faces. The game makes it easy to find these ghoulish fiends, but we've found a few places you might want to consider traveling to so that your ghost collection is looking fresh and full! Here are 10 places you should considered going to for your ghostly needs.
For those of you who live in bigger cities, or perhaps live in a famous town, tourist attractions are always a must for any AR mobile game. These are places where you can find virtually anything because there are enough people there to play with you and enough ghosts to go around. It's an inviting place that lets you see something cool in real life while also attracting some interesting ghosts to the location.
If you're out running errands at the mall or shopping centers, you might want to bring your phone along just in case you run into any ghostly figures! Malls and shopping centers are typically safe public spaces that allow you to walk around freely. There's enough space in either of these places that you can easily find some rare ghosts and maybe even a boss or two if a nearby shop is on the list for a baddy!
Public recreational centers are fun places to get some exercise and also take some community classes! There's plenty to learn, but if you're a Ghostbuster, there's just as much to catch. Recreational centers tend to be huge hubs for people to get together, which means that it also tends to be a place that ghosts might want to haunt. It's definitely worth looking around your closest center to see if there's anything floating about.
Theme parks and national parks are a lot different than your average community hang out. Usually, these places are flooded with people and tend to attract just as many AR characters to the scene. Whether you're out on a trip to look at the wonderful nature the real world has to offer or you just want to find some extreme roller coasters, these are fun spaces that are packed with plenty of fellow players and some fun stuff to do outside of your mobile game.


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Cherry Orchard were proudly represented by two our pupils and their families at the final of the Premier League Primary Stars Football Final on Saturday. Toby Allen and Kayode Adedigba were invited to attend the final along with the families as guests of Dartford Football Club.
The day started brilliantly with two excellent National League Trust schools 6aside finals between Wentworth/Stone St Mary's boys and Joydens Wood/Bean girls. Wentworth & Joydens Wood will now progress to represent Dartford Football Club in the next stage, with the end goal a final at Wembley Stadium.Before kick off pupils and staff from 21 local primary joined us on the pitch for a photo. Thank you all for coming, Bean, Brent, Craylands, Cherry Orchard, Dartford Primary, Dartford Bridge, Fawkham, Gateway, Greenlands, Hextable, Holy Trinity, Joydens Wood Juniors, Milestone, New Ash Green, Oakfield, Stone St Mary's, Sutton at Hone, Temple Hill, West Hill, Westgate and Wentworth
The winner of the kit and equipment will be announced this week!! Dartford FC Community look forward to introducing new initiatives and continue delivering our Premier League Primary Stars, Reading Mentors, DFC Education Programme, Lunch Clubs, Enrichment Days and a variety of festivals with schools in 2020.


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Zuma seeks interdict, stops Madonsela releasing state capture report
President Jacob Zuma has applied for an interdict to prevent Public Protector Thuli Madonsela from releasing her report on state capture. Madonsela has been investigating whether certain organs of state have been "captured" by private, politically connected interests. Zuma served Madonsela with the notice on Thursday' which will mean the Public Protector will not be able to release the report on Friday' as she had planned. Zuma was meant to meet Madonsela on Monday to clarify outstanding questions about the Gupta family's role in the appointment of Des van Rooyen as finance minister, but he did not pitch at the meeting. Both Zuma and the Guptas have this week demanded to interview Madonsela's witnesses in the probe.
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July 4th pics
We had a great, low-key July 4th celebration at Michael and Liz's house. The kiddos played so well and were so good. The weather even cooperated and there was no rain, and it even wasn't too hot outside. We came home and set off a few fireworks of our own. Camden thoroughly enjoyed himself, but Rory was so tired that she just wanted to get into bed!
Cute Patooties


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This workshop is based on the research and treatment done by Professor Janet Treasure and her colleagues at the Maudsley Hospital in London and at other centres around the world. The workshops will give you the chance to learn and practice skills in:
- Understanding eating disorders
- Ways to communicate with your loved one
- Understanding where your loved one is at with their motivation and helping them with this
- How to help your loved one with difficult emotions
- Taking care of yourself and the other relationships in your life
Dates: Thurs 2nd July – Thurs 30th July 2020
Time: 9-11am OR 1:30-3:30pm dependent on majority preference
How: Live online
Cost: The group itself is free, but please note it is essential you buy a book 'Skills Based Learning for Caring for a Loved One with an Eating Disorder' by Janet Treasure, Grainne Smith and Anna Crane. Available online via Amazon books, ABE books or other major online book distributors.


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The best investment one could make is self-investment. Learning about who you are and what makes you tick is an incredibly useful data point. Through the last several years, I have found that the more I learn about myself, the happier I become.
I hope you enjoyed your weekend and brought in the new year with those you loved. This post was motivated by a Facebook post the summer of 2017, which I spent in Colorado.
The message is incredibly important to me; I find it to be one of the most important lessons I've learned during my short time here. In the new year, if you don't do anything else, I would encourage you to learn about yourself.
It wasn't until recently that I even knew public lands existed. Growing up in Texas, where almost all the land is privately owned, I just assumed it was like that everywhere.
My assumptions were inaccurate but I came to that conclusion with all the info I had. Many times we form opinions based on only the evidence we have, not knowing everything else.
Through my travels, I've learned so much, about this great land we're blessed to live in but also, and more importantly, about myself and who I am.
"Know thyself."
Every place I visit, every view I find myself lost in, teaches me the slightest little bit about myself and where this journey of life will lead me.
"Why do you go away? So that you can come back. So that you can see the place you came from with new eyes and extra colors. And the people there see you differently, too. Coming back to where you started is not the same as never leaving."
– Terry Pratchett
I would encourage everybody to go away, even go by yourself. Force yourself to spend some alone time in some places that you have no comforts to resort to. I guarantee that you'll learn more about yourself than you ever would imagine.


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Lazer Tag
West Texas Lazer Tag
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When we come to your event we want to ensure a safe and fun time. We have our own movable bunkers that participants can hide behind and if you want to keep everyone really far apart we can have them play 1/4 mile away from each other. These guns allow you to dictate the terms and ensure a fun time will be had by all at your event.
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Please make sure you book well in advance, remember reservations are first come, first serve. If you have additional questions or are ready to make a reservation, contact us at (432) 558-9222.


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Healthy Eating by Shelby Shelby
Ideas for Your Holiday Leftovers
Leftover turkey and dressing are commonplace during the holidays, but after putting in so much hard work to prepare these dishes it's a shame to see them go to waste. Instead of throwing away those turkey and dressing leftovers, try out these ideas to repurpose your favorites into a new dish.
Leftover turkey is a great lean meat to include in healthy meals. Throw turkey into any meal where you usually use chicken: turkey noodle soup, turkey and rice casserole, or even on top of a garden salad. Leftover turkey is also a great alternative to high sodium deli meat. Add your leftover turkey (and a little cranberry sauce) to a sandwich for a low sodium, tasty lunch option. If you don't plan to finish your turkey right away, go ahead and freeze it for healthy meals in the New Year. Frozen cooked turkey lasts well in the freezer for 2 to 6 months. Use up your frozen turkey just as mentioned above.
While dressing is undoubtedly a staple of Thanksgiving meals, leftover dressing is one of the most commonly wasted items. While it is a little harder to repurpose dressing, a little creativity can help you use it all up. Dressing is a great base for a casserole. Mix together leftover dressing, cheese, meat, vegetables and extra broth if needed and add the mixture into an oven safe dish. Bake until the casserole reaches an internal temperature of 165 F. To make this casserole a MyPlate meal for your family just add fruit and milk on the side. You can also convert your leftover dressing into savory muffins. Just divide leftover dressing into a muffin tin and cook until browned and crispy. Serve these savory muffins with breakfast or as a grain option at dinner. Freeze whatever you don't finish. Another creative way to repurpose is to add leftover dressing to meatballs instead of bread crumbs. Think about how tasty those meatballs with be!
Try out these tips to avoid food waste this holiday season and share with us ways you like to repurpose your holiday leftovers.