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Yesterday we sailed from Geiranger around 16.00 hrs. and made a 360o swing stop at the Seven Sisters waterfall on the way out. As part of the goodbye celebrations for the ship, the company had arranged for a deck party with complimentary drinks. So the deck area around the Lido Pool was packed with guests enjoying snacks such as Dutch Bitterballen and Indonesian Sate and free drinks.
With the ships officers and (guest) entertainers circulating among the guests a good time was had by all while watching the impressive scenery. It was a bit strange for me as I was always on the bridge when we were here but now being a guest entertainer for this cruise, my place was in the bar. I did not need much time to adapt myself fully to the new circumstances………………….
Today we are in Flam located at the end of the Eidfjord. Well at the end is not completely true as it continues a little bit on the far side of where we are but as far as ships go this is the end; the terminal of the Flam train and the main reason we are here. The little train port has one dock and that is made to the size of the Hurtigruten postal boats and thus most ships overhang. Even the Prinsendam is sticking out with the bow and the stern. And we did dock as we were the only cruise ship in port today. And as the cruise ship season is now in full swing, we were thus quite lucky. With another ship in, the chance that that ship would have been smaller than us would be quite remote and thus we would have been bumped to the anchorage. To accommodate large cruise ships, they have installed heavy bollards outside the dock area to ensure that the very big boys can dock as well. And those big boys are coming in and thus the trains going up and over the mountain are getting longer and longer as well. With the Prinsendam a considerable number of guests have been here before and up & down with the train so they either stayed on board or went for a walk around the train station and up and down the roads nearby.
On board the packing up is in full swing and also the completion of all routine activities. Everybody is running around with carton paper to make boxes and the recycling center which normally piles up the carton for recycling ashore now sees carton going the other way for packing up purposes. Which I suppose is a sort of recycling and re-use as well. This whole pack-up operation takes an enormous amount of planning, even with the ship staying as it is. The new operator basically takes over everything that is nailed to the ship and is not specific Holland America. Thus for the last few months certain HAL inventory items have already been transferred to other ships. Those items we call Slow-Inventory-Moving- Items. These will be used in the long run but are not needed every day. How many cooking pans do you need spare on board, how may bathrobes do you need to have in stock outside the regular cycle in use? Thus many inventory items have been moved to other ships already.
Items that were or might have been needed for the last voyages remained on board and are now being packed up and most of it will be transferred to the ms Rotterdam, docked behind us in Amsterdam on 1 July. Bar and Housekeeping inventory will simply become part of the RTDM inventory as they use the same items. And so each department doing their own little thing and is packing up boxes for transfer/ shipment. Crew is clearing out their cabins and that is separate from packing-up. It is amazing what crew members build into their cabins through the years. Little shelves, foldable seats, little stools, everything to make a standard crew cabin more homely and practical. The cabins have to be delivered clean and ready for use, regardless of what the new owner is going to do with them, and thus a recycle center was set up in Boogie Plaza where everything coming out of the cabins was sorted into trash, plastic and recyclables.
I have blogged about this in the past, but the crew areas on board of Royal Viking Sun, were given specific names. Such as Broadway (guess who lives there) and also we have Boogie Street and Boogie Plaza named after a famous street in Singapore. Boogie Plaza is the large crew area on deck 4 in front of the forward staircase. Sometimes we have our gangway there and then the guest see what it is. Around it are the crew elevators, the crew bicycle storage and the Crew Office so it is a major crew congregation area.
We will sail from Flam at 19.00 hrs. and then follow an inside passage to get to Bergen. Most ships have to go outside as there is a bridge in the way but the ms Prinsendam fits under this bridge, as well as under a lot of other bridges in Norway and thus we stay inside. Always handy when it is bad weather but it is also a shorter route.
We expect to be docked tomorrow morning by 08.00 hrs. and will stay until 22.00 hrs. giving the guests the chance to enjoy Bergen by night, although it will still be daylight. So I hope for dry weather but the weather forecast mentions a chance of showers in the evening but not that great a chance. But in the morning and until the midafternoon it should be partly cloudy with noon temperatures around 18oC / 65oF and that is high summer for the Norwegians. We will not be alone as on the schedule to be with us are the Ocean Majesty (A small ship on which my wife once worked; we considered that not a cruise line but a "happening") and the Vasco Da Gama. She was originally the ms Statendam of Holland America Line so it will be nice to see my old ship back where I was captain in 2001 and 2011 – 2014.
Today four other crew photos and this time from our Concessionaires. Concessionaires are employed by an outside company's that have concessions on board. Such as the Photographers, the Casino, the Shops and Green House Spa. Although not Holland America crew, they are still an integral part of the ships' crew and some of them arrange it so that contract after contract they remain with Holland America Line. And thus I feature them on the blog.
The photographers are considered a concession but they are really part of the company at large. It is just that they work directly with their colleagues in the fleet and not so much as an integrated team in the ships Hotel Department.
The shops on board are located on deck 8 behind the Front Office. To make things complicated the shops are manned by two concessions, one for the regular duty free and another one for the Jewelry. Both entities are overseen and coordinated by a Retail Manager who is employed by Holland America Line.
The ships Casino is located on Deck 8 portside aft, just behind the ships Explorations Centre. This is the end of an era for the Casino as the new owner has decided that it does not need a casino and thus the area will be changed into 10 cabins.
The Greenhouse Spa is located aft on deck 9, where there are sauna's on the portside, a fitness area in the centre and treatment rooms and Beauty Parlor on the Starboard side.


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Your HVAC system helps your family feel comfortable in your Swannanoa, North Carolina, home. To ensure it's operating efficiently, it's essential to watch for signs that it may need a repair. One way your HVAC system tells you it's experiencing a problem is by making an unusual noise. If you hear any of these four noises coming from your HVAC system, you should consider scheduling an inspection before it's too late:
Every moving part in your HVAC system should be properly lubricated in order for it to operate at peak efficiency. Lubricant prevents parts from wearing out too early or becoming damaged. An irregular squealing noise is a sign that the parts in your HVAC system need more lubrication.
Banging noises coming from your HVAC system signal that you have a broken or loose part. Either issue can pose an immediate danger to your system. A broken part will need to be replaced. A loose part can move around and cause damage to the other parts of your system. Therefore, it's imperative that you contact a professional right away if you hear banging noises coming from your HVAC system.
A persistent rattling noise is often a sign of damage to the furnace blower motor. It could signify a repair need or that the motor is starting to fail. You should address this issue immediately. Otherwise, it can cause the entire system to break down, requiring you to replace it.
If you have an older gas furnace, you may have heard this sound once or twice. Since there's no immediate problem occurring directly after, you most likely ignore it and go on about your day. Unfortunately, these booms are a signal that there's a delay in the ignition that causes gas to accumulate, which can result in a dangerous situation. To avoid endangering your family, let a professional take a closer look.
Do you hear any of these HVAC noises? Don't wait for a small problem with your heating system to turn into a major repair or replacement. Contact Gentry Heating, Inc. at 828-581-4045 for help diagnosing the noises and resolving them right away.
Image provided by Shutterstock

subset: commoncrawl


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Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol
Author + information
- Received January 31, 2000
- Revision received July 11, 2000
- Accepted August 18, 2000
- Published online December 1, 2000.
Author Information
- Lothar Rössig, MD∗,
- Judith Haendeler, PhD∗,
- Ziad Mallat, MD†,
- Benedicte Hugel, PhD‡,
- Jean-Marie Freyssinet, PhD‡,
- Alain Tedgui, PhD†,
- Stefanie Dimmeler, PhD∗,* (Dimmeler{at}em.uni-frankfurt.de) and
- Andreas M Zeiher, MD∗
- ↵*Reprint requests and correspondence: Dr. Stefanie Dimmeler, Molecular Cardiology, University of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
The purposes of this study were to determine whether the serum of patients with congestive heart failure (CHF) can induce apoptosis of endothelial cells and to elucidate the underlying mechanisms. Moreover, the effect of the beta-blocker carvedilol was investigated.
Congestive heart failure is associated with impaired endothelial function in the peripheral systemic vasculature and with systemic release of inflammatory cytokines. Pro-inflammatory cytokines have been shown to induce endothelial cell apoptosis in vitro. Therefore, we hypothesized that CHF is associated with enhanced apoptosis of endothelial cells.
Human umbilical vein endothelial cells were exposed to the serum of patients with CHF (n = 15) or healthy volunteers (n = 11), and apoptosis was determined by fluorescence staining of the nuclei and demonstration of deoxyribonucleic acid laddering. Moreover, apoptotic membrane particles were detected in plasma samples of patients with CHF.
The serum of patients with CHF revealed a significantly enhanced pro-apoptotic activity as compared with age- and gender-matched healthy volunteers (p < 0.001). Furthermore, patients with CHF revealed significantly elevated plasma concentrations of apoptotic membrane particles. Apoptosis of endothelial cells correlated with elevated tumor necrosis factor-alpha (TNF-alpha) (r = 0.585, p = 0.002) and soluble TNF receptor serum levels (r = 0.517, p = 0.007). Carvedilol completely suppressed the increase in apoptosis induced by the serum of patients with CHF. Moreover, carvedilol dose-dependently inhibited TNF-alpha–induced apoptosis. The antiapoptotic activity of carvedilol was mediated by reduced activation of the caspase cascade through inhibition of mitochondrial cytochrome c release. The suppression of apoptosis by carvedilol was due to its antioxidative rather than beta-blocking effects, as the analogue BM91.0228, which has no beta-blocking activity, exerted similar effects.
These findings indicate that endothelial cell apoptosis may play a role in the pathophysiology of heart failure. Inhibition of endothelial cell apoptosis by carvedilol may contribute to the beneficial effects of carvedilol in patients with heart failure.
Increased peripheral vascular resistance is a hallmark of congestive heart failure (CHF) (1). The impaired functional capacity of peripheral blood vessels to dilate in response to increased flow is a major determinant of the degree of exercise intolerance, one of the most important clinical features of patients with heart failure (2,3). The deficit in peripheral vasodilator capacity results from attenuated vascular endothelial function (4) and has been attributed to a loss of the ability of the endothelium to release nitric oxide in response to physiologic stimuli (5,6). Immunologic and inflammatory responses may play a pathogenetic role in the development of CHF (7). Congestive heart failure is associated with elevated circulatory levels of pro-inflammatory cytokines, such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha (TNF-alpha) (8–10), as well as C-C chemokines (11). All these cytokines cause endothelial cell dysfunction either directly or through the generation of reactive oxygen species (12,13), providing a potential pathophysiologic link between the loss of normal endothelial function and CHF.
Apoptosis or programmed cell death is a characteristic feature of endothelial cell activation after stimulation of systemic inflammatory responses in vivo (14). In addition, incubation with pro-inflammatory cytokines and reactive oxygen species induces endothelial cell apoptosis in vitro (12,13,15). Apoptosis is morphologically characterized by cell shrinkage, membrane blebbing, chromatin condensation and deoxyribonucleic acid (DNA) fragmentation (16). These stereotypical changes are accomplished by complex biochemical events involving the activation of cysteine proteases called "caspases" (17). The activation of initiator caspases by various stimuli triggers the release of mitochondrial cytochrome c, which in turn activates the multiprotein "poptosome" ensemble, composed of Apaf-1, cytochrome c and pro-caspase-9 (18,19). Activation of pro-caspase-9 then processes and activates other caspases to orchestrate the biochemical execution of cell death (20).
A very recent study suggested that the serum of patients with CHF induces endothelial cell apoptosis in vitro (21). Therefore, we investigated the signaling cascade involved in heart failure serum-induced apoptosis of endothelial cells. In addition, we examined whether apoptosis also occurs in vivo, thus providing a potential mechanistic link for the impaired endothelial function in patients with CHF. Moreover, we examined the effects of the neurohormonal antagonist carvedilol, which has been shown to exert beneficial effects in patients with CHF (22). The results of our studies demonstrate that the serum of patients with CHF induces apoptosis of endothelial cells through activation of the caspase cascade. Carvedilol suppresses activation of the caspase cascade by inhibiting mitochondrial cytochrome c release and significantly reduces endothelial cell apoptosis induced by the serum of patients with CHF.
Patients and control subjects
Fifteen patients with CHF were studied (Table 1). Patients received standard treatment for heart failure, consisting of angiotensin-converting enzyme inhibitors, diuretics and digitalis. Patients with elevated serum creatinine levels (>1.4 mg/dl), infectious or pulmonary disease or myocardial infarction within the last three months were not included. In addition, six patients receiving carvedilol treatment (6.25 to 50 mg/day; plasma levels 14.99 ± 7.4 μg/liter) were studied. Eleven healthy age-matched volunteers (six men and five women; mean age 50 ± 11.6 years) with no history of cardiac disease served as the control group. Venous blood was drawn into 10-ml serum tubes without additives. After centrifugation, serum aliquots were frozen at −80°C. The Ethics Committee of the University of Frankfurt approved the study protocols, and written, informed consent was obtained from all study participants.
Carvedilol (1-[9H-carbazol-4-yloxy]-3-[(-[2-methoxyphenoxy]ethyl) amino]-2-propanol) and its analog BM91.0228 (4[2-hydroxy-3-][2-(2-methoxyphenoxy)ethyl amino-propoxy]-9H-carbazol-3-ol) were kindly provided by Dr. Sponer (Boehringer Mannheim, Germany). Propranolol hydrochloride was from Zeneca (Plankstadt, Germany); Z-Val-Ala-DL-Asp-fluoromethylketone (ZVADA-fmk) was from Bachem (Heidelberg, Germany); and human recombinant TNF-alpha and anisomycin were from Sigma (Munich, Germany).
Cell culture
The human umbilical vein endothelial cells (HUVECs) (Cell Systems/Clonetics, Solingen, Germany) were cultured in endothelial basal medium supplemented with hydrocortisone, bovine brain extract, gentamicin, amphotericin B, epidermal growth factor and 10% fetal calf serum until the third passage before experiments were performed.
Detection of apoptosis
Assessment of apoptotic nuclei and internucleosomal DNA laddering were performed as described previously (12,23). The amount of apoptotic particles in human plasma samples was measured according to Aupeix et al. (24). Results were expressed as nanomolar phosphatidylserine normalized by a standard curve using liposomes of a defined composition. In addition to apoptosis assessment, cell viability was determined with the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay, as previously published (12).
Cytokine measurements
Tumor necrosis factor-alpha and soluble TNF-receptor 1 (sTNF-R1) serum levels were measured by commercially available enzyme-linked immunosorbent assay kits (R & D Systems, Wiesbaden, Germany).
Mitogen-activated protein kinase (MAPK) assays
The activity of c-JUN NH2-terminal kinase (JNK) was detected by using a nonradioactive assay (New England BioLabs, Frankfurt am Main, Germany). Phosphorylation of p38 was assayed by Western blotting using a phospho-specific antibody against phosphorylated Thr-180 and Tyr-182 of p38 MAPK (New England Biolabs).
Plasmids and transfection
Caspase-8 was cloned into the pcDNA3.1 vector, as previously described (25). The HUVECs were transiently co-transfected with 3-μg plasmids using Superfect (Qiagen, Hilden, Germany) (23). Transfected cells were identified by beta-galactosidase staining. Stained cells were analyzed by two investigators in blinded manner, and the results were expressed as dead/viable cells × 100.
Caspase-3–like enzyme activity
Caspase-3–like activity was detected by measuring cleavage of the fluorogenic substrate 7-amino-4-coumarin-Asp-Glu-Val-Asp, as previously published (12).
Cytochrome c release
The mitochondrial versus cytosolic fractions were separated, Western blotted and probed with anti-cytochrome c antibody (PharMingen, San Diego, California), as described (26).
Data are expressed as the mean value ± SD. Continuous variables were tested for normal distribution with the Kolmogorov-Smirnov test. Differences between two treatment groups were analyzed by use of the independent samples t test. Three or more groups were compared by means of one-way analysis of variance followed by post-hoc analysis with the Bonferroni correction for multiple comparisons. Categorical variables were compared by means of the chi-square test and the Fisher exact test. Apoptosis rates of subgroups of patients with CHF, according to New York Heart Association (NYHA) functional classes, and apoptotic membrane particles are presented as the mean value ± SEM. Linear regression analysis and nonparametric bivariate correlation (Spearman rank correlation coefficient [rs]) were used to compare apoptosis rates with TNF-alpha serum levels. Statistical significance was assumed if a null hypothesis could be rejected at p = 0.05.
Serum of patients with heart failure induces endothelial cell apoptosis
Exposure of HUVECs to the serum of patients with CHF led to a significant increase in apoptosis compared with the serum of healthy volunteers (4.3 ± 0.7% vs. 2.9 ± 0.9%), as demonstrated by morphological analysis of cell nuclei (Fig. 1A), as well as by DNA laddering (Fig. 1B). Moreover, CHF serum significantly reduced cell viability (Fig. 1C). The extent of serum-induced endothelial cell apoptosis correlated with the functional status of the patients (Fig. 1D). The serum of patients with severe CHF (NYHA class III and IV) revealed a significantly enhanced pro-apoptotic activity compared with the serum of patients in class II (p < 0.05). To test the in vivo relevance of these in vitro findings, apoptotic particles were measured in human plasma. As shown in Figure 1E, plasma levels of apoptotic particles were significantly increased in patients with CHF compared with healthy control subjects.
The pro-apoptotic cytokine TNF-alpha has been shown to be elevated in CHF (10). Indeed, serum levels of TNF-alpha and sTNF-R1 were significantly increased in patients with CHF compared with healthy volunteers (Fig. 2A). Apoptosis induction in vitro correlated with TNF-alpha serum levels (Fig. 2B). A similar correlation was observed between apoptosis rates and sTNF-R1 serum levels (r = 0.517, p = 0.007), suggesting a link between pro-inflammatory cytokine levels and endothelial cell apoptosis in CHF.
Because activation of the caspase cascade is central to apoptosis signaling, we investigated whether serum-induced apoptosis of endothelial cells involves caspase activation. Complete inhibition of caspases by ZVAD-fmk abolished serum-induced endothelial cell apoptosis (Fig. 3A). Thus, apoptosis of endothelial cells induced by the serum of patients with CHF depends on activation of the caspase cascade.
Carvedilol suppresses endothelial cell apoptosis induced by serum of patients with CHF
Carvedilol has been shown to be effective in the management of CHF (22). Therefore, we tested the effect of carvedilol on endothelial cell apoptosis. The addition of carvedilol suppressed the induction of apoptosis by the serum of patients with CHF to control levels (Fig. 3, A and B). Moreover, carvedilol slightly but not significantly decreased apoptosis of HUVECs in the presence of control serum (20.6 ± 15.2% inhibition). Next, we tested the in vivo relevance of the apoptosis-suppressive effect of carvedilol. Apoptosis induction by the serum of patients with CHF receiving carvedilol treatment (n = 6) was significantly lower compared with the serum of patients without treatment (3.5 ± 0.8 vs. 4.5 ± 0.7%, p < 0.05).
Carvedilol inhibits apoptosis by means of its antioxidative properties
To characterize the mechanisms by which carvedilol prevents apoptosis, the effects of carvedilol on stimulus-induced apoptosis were determined in vitro. Co-incubation with carvedilol dose-dependently reduced TNF-alpha–induced apoptosis in endothelial cells (Fig. 3, C and D). Therefore, we tested whether the beta-adrenoreceptor antagonistic or the antioxidative effect accounts for the antiapoptotic action of carvedilol. The hydroxylated analogue BM91.0228, which is a potent antioxidant but lacks beta-blocking activity, led to a similar suppression of apoptosis, whereas both propranolol, a beta-blocker without antioxidative properties, and the alpha-blocker prazosin had no significant effect on TNF-alpha–induced apoptosis (Fig. 3D; data not shown). Thus, inhibition of endothelial cell apoptosis by carvedilol appears to be due to its antioxidative properties.
Carvedilol inhibits apoptosis signaling by suppressing cytochrome c release
Previous studies using cardiac myocytes have suggested that the antiapoptotic effect of carvedilol is mediated through inhibition of the stress-activated JNK pathway (27). In endothelial cells, TNF-alpha–induced activation of JNK was not prevented by co-incubation with carvedilol (Fig. 4A). Carvedilol also had no effect on TNF-alpha–induced activation of p38 MAPK (Fig. 4B). Thus, the antiapoptotic effect of carvedilol on endothelial cells appears to be mediated by other mechanisms. Therefore, we determined the effect of carvedilol on the distal pro-apoptotic cysteine protease caspase-3 (28). Both carvedilol and its antioxidative analogue BM91.0228, but not propranolol, significantly inhibited TNF-alpha–induced caspase-3 activation (Fig. 5A). Moreover, carvedilol and BM91.0228 significantly suppressed apoptosis induction by overexpression of caspase-8, which links cytokine receptor stimulation to the caspase cascade. (Fig. 5B). Next, we tested whether interference with the mitochondrial cytochrome c release may account for the antiapoptotic effect of carvedilol. Co-incubation with carvedilol significantly reduced the TNF-alpha–triggered release of cytochrome c into the cytosol (Fig. 5C). These results suggest that carvedilol stabilizes the mitochondrial membrane in endothelial cells and thus prevents TNF-alpha–mediated caspase-3 activation.
The activation of endothelial cells, which results in impaired peripheral vasoactivity, may play an important role in the pathophysiology of CHF. The results of the present study confirm recently published data (21) showing that the serum of patients with CHF induces endothelial cell apoptosis in vitro. More importantly, the increase of plasma-shed membrane particles in patients with CHF indicates that apoptotic cell death also occurs in vivo. The pro-apoptotic serum effects correlate with the systemic inflammation indicated by increased levels of TNF-alpha and sTNF-R1 and suggest that circulating factors may directly damage endothelial cells in CHF. Mechanistically, our data demonstrate that the injury to endothelial cells is mediated by activation of the caspase cascade. Carvedilol, which has been shown to have beneficial effects in patients with CHF, inhibits activation of the caspase cascade by blocking mitochondrial cytochrome c release and completely suppresses apoptosis induction in endothelial cells by the serum of patients with CHF. These findings may provide novel and important insights into the potential mechanisms underlying the beneficial effects of carvedilol.
Involvement of apoptosis in cytokine-mediated endothelial injury in CHF
Congestive heart failure is associated with increased circulating levels of pro-inflammatory cytokines (7–9). The inflammatory response correlates with the severity of CHF symptoms (10,11) and has been suggested to play a pathogenetic role in the development of CHF (29). The results of the present study considerably extend these findings by demonstrating that increased circulating levels of TNF-alpha and sTNF-R1 in patients with CHF are associated with the induction of endothelial cell apoptosis in vitro. This could provide a mechanistic link between CHF and endothelial dysfunction.
Mechanisms of endothelial cell apoptosis induction in CHF
The precise serum factor(s) responsible for activation of the caspase cascade in endothelial cells remain to be determined. We have previously shown that TNF-alpha (12), reactive oxygen species (13,30) and angiotensin II (31) all represent potent activators of the caspase cascade, leading to endothelial cell apoptosis. All these factors are elevated in serum of patients with CHF (10,32,33). Serum activation of endothelial cells was followed by apoptosis induction, even in the presence of neutralizing antibodies against TNF-alpha (data not shown) (21). Thus, mediators other than TNF-alpha contribute to the activation of caspases in endothelial cells. However, regardless of the identity of the caspase activator(s), apoptosis induction was directly related to the severity of symptoms in patients with CHF, reflecting the relevance of endothelial cell apoptosis as a pathogenetic mechanism in this disease.
Effect of carvedilol on endothelial cell apoptosis in CHF
Carvedilol, which reduces mortality and worsening of symptoms in patients with CHF (22,34), leads to peripheral vasodilation through blockade of alpha1 receptors and acts as an antioxidant, in addition to its nonselective beta-blocking activity (35). Recently, some of the beneficial effects of carvedilol have been suggested to rely on the inhibition of cardiac myocyte apoptosis (27), which may contribute to the progression of heart failure (36). The present study now provides evidence for an additional vasculoprotective effect of carvedilol—namely, the suppression of increased endothelial cell apoptosis induced by the serum of patients with CHF. In contrast with cardiac myocytes, the antiapoptotic effect of carvedilol in endothelial cells was not related to JNK or p38 inhibition, but involved the reduction of mitochondrial cytochrome c release. The mitochondrial membrane "stabilizing" effect of carvedilol is mediated through its antioxidative action, because the analogue BM91.0228, which has no beta-blocking activity, was equipotent to carvedilol in apoptosis inhibition. The antioxidative capacity of carvedilol in vivo has recently been documented by a reduction in the oxidative modification of lipid products in volunteers during a seven-day treatment period with carvedilol (37). However, the results of the present study do not discard the possibility that beta-blockers, with no direct in vitro antioxidant properties, might likewise reduce the incidence of endothelial cell apoptosis in vivo in patients with CHF. Indeed, it has recently been demonstrated that carvedilol and metoprolol treatment is associated with equipotent reductions in systemic oxidative stress, as measured by thiobarbituric acid reactive substances (TBARS) in patients with CHF (38). Importantly, TBARS formation directly correlates with the functional severity of CHF as assessed by the NYHA classification (32). Therefore, the functional improvement of patients with CHF receiving beta-blocker therapy might be associated with reduced oxidative stress, which will translate into a beneficial effect upstream of caspase activation and cytochrome c release, irrespective of the direct antioxidant properties of the beta-blocking agent.
The results of the present study demonstrate that the serum of patients with CHF potently induces apoptosis of endothelial cells, providing another possible mechanistic clue in the pathogenesis of endothelial dysfunction in patients with CHF. The inhibition of endothelial cell apoptosis by carvedilol through prevention of mitochondrial cytochrome c release discloses a novel mechanism, which might contribute to its beneficial effects in the management of patients with CHF. In general, interventions that interfere with the induction of apoptosis of endothelial cells may provide a novel therapeutic target in patients with CHF.
We thank Susanne Ficus and Meike Stahmer for their expert technical assistance.
☆ This work was supported by grants from the Deutsche Forschungsgemeinschaft Di 600/2-3 and SFB-553.
- Abbreviations
- congestive heart failure
- HUVECs
- human umbilical vein endothelial cells
- c-JUN NH2-terminal kinase
- mitogen-activated protein kinase
- 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide
- New York Heart Association
- sTNF-R1
- soluble tumor necrosis factor–receptor 1
- thiobarbituric acid reactive substances
- TNF-alpha
- tumor necrosis factor-alpha
- ZVAD-fmk
- Z-Val-Ala-Asp-fluoromethylketone
- Received January 31, 2000.
- Revision received July 11, 2000.
- Accepted August 18, 2000.
- American College of Cardiology
- ↵
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Najmi Muhammad
Najmi Muhammad is a jack of all trades in the financial world. His titles include, but are not limited to: Certified General Accountant, real estate agent, mortgage agent and a licensed insurance agent. His many certifications allow him to provide his clients with a one-stop shop to suit their ever-changing needs. These clients include both individuals and corporations, as Najmi heads two companies.
Currently, Najmi resides in Markham, Ontario with his wife and three children. When he has spare time, he can be found relaxing with his family, supporting a local nonprofit called CRC which provides services and education to women and children, and learning. As someone who wears many hats, learning and forming new skills is like a second nature.When a new opportunity arose, he would find a class that would teach him how to add the skills to his repertoire.


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Michigan State Senator Peter Lucido (R-Shelby Township) and unnamed De La Salle Collegiate students #sexist freep.com
LANSING – A state senator is facing widespread criticism and an investigation in the Legislature after telling a female reporter she should stick around at the Capitol because a group of high school students from an all-boys school, touring the Capitol, could "have a lot of fun" with her.
Sen. Peter Lucido, R-Shelby Township, made the comments outside the Senate chamber Tuesday to a reporter from the Michigan Advance, while surrounded by a group of male high school students from De La Salle Collegiate in Warren.
"You've heard of De La Salle, right?" the Michigan Advance quoted Lucido as asking reporter Allison Donahue, who is 22.
When Donahue said she had not, Lucido said: "It's an all-boys school," adding: "You should hang around — you could have a lot of fun with these boys, or they could have a lot of fun with you."
The students then burst into laughter, the online publication reported.
The Republican and Democratic leaders of the Senate announced Wednesday afternoon they have asked the Senate Business Office to investigate whether the incident violated Senate rules related to sexual harassment.


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JL Roberts and Nadia Kamil Present Wisecrackin' Midsqueezin' Behemoth
Note: This review is from 2008
A little participation was required of this diminutive but discerning audience, when we were required to read from a flipchart, a role which was executed with a mixture of aplomb and reluctance.
Opening with a ludicrous, and some would argue unlikely, conversation between a man in the past and a man in the future was followed by a song for the sponsors and then into a whole realm of barmy notions - a running gag involving the sale of bunk beds and mistaken celebrity identity was one of the most enjoyable.
Ideas spark off each other juxtaposing some of the most unlikely elements as the set roamed about, from Banksy to the pair's hermaphrodite mother/father.
Familiar ideas and topics that also make an appearance are given an off-the-wall twist; the latest new coffee product available on a street corner is the Slappaccino – less of a drink and more a slap in the face (when this skit and one on etiquette are performed the front row might want to consider staying in their wet weather gear).
Though Kate Bush has been the object of parody for a few acts this year, Roberts produces the most unhinged of the lot, creating an image that certainly endures in the memory.
A quirky slice of festival fodder that more people should be checking out.
Reviewed by: Marissa Burgess
Review date: 1 Jan 2008
Reviewed by: Steve Bennett


text:
– by Josh Painter
With speculation in the lamestram media alread rising to a fever pitch over Sarah Palin's decision not to attend C-SPAN, the governor emailed The Washington Post blog the Fix Thursday with an official explanation:
"February is our busiest winter month and with all the prior obligations and outside travel already scheduled for the month I had to forgo some of the opportunities in the Lower 48."
It was indeed a scheduling issue, not a personal one or any other reason, as CPAC's David Keene had said:
"We're disappointed that she couldn't make it year. It's due to a scheduling issue. We look forward to having her next year, and she expressed interest in wanting to be there this year."
Not that she even needs CPAC anyway, as even The Fix's Rachel Weiner has to admit:
"…unlike some other potential nominees, Palin doesn't need to raise her profile. She can draw press wherever she goes."
"Even in her absence, however, Palin will have a significant influence. She is, as we have written, the prime mover in the presidential race and until she makes clear whether or not she will run in 2012, she will be a presence at any gathering of would-be presidential aspirants — whether she is actually in attendance or not."
Blogs 4 Palin blogger Jerry Wilson had already pointed this out in his post January 30 at Goldfish and Clowns:
"…it must stick firmly in the throat of Washington insiders and wannabes that Sarah Palin can bypass them without missing a beat. She can pick her spots, selecting such prizes as being the keynote speaker at a high profile sanctioned event marking Ronald Reagan's one hundredth birthday. She speaks to more people in a second with one Facebook page than all the speakers at CPAC combined will reach in a year. Simply put, Palin doesn't need CPAC. And she doesn't seem all that inclined to make an appearance there because it's been elevated to mandatory status by those seeking to enhance their own status."
Cross-posted from Texas for Sarah Palin


text:
Frequently Asked Questions
How much experience do you have in the transport industry?
Over 32 years. Paul Camilleri Express - now P One Express Group trading as Camex Transport Services - started transport operations in 1985.
What sort of transport do you specialise in?
Camex specialise in transporting: sawn timber, steel products, pre-cast concrete, general freight, portable and oversize building sections and shipping container units. We also offer secure short-term storage and overnight truck-layover solutions. We are mainly engaged in third party logistics (3PL). We have a strict "no trucks left unattended on suburban streets" policy.
Here's a list of some of the things Camex can transport:
- Sawn timber, packaged timber and decking packs
- All types of beams and bars - timber, steel & formwork
- Oversized loads - relocatable buildings, building sections, tiny houses & site sheds
- Steel mesh, precast concrete, marble, bricks & blocks, and building supplies
- Pallets - standard & odd sizes, palletised freight and crated freight
- Formwork, fencing, bollards, barocades, packaging and dunnage
- Containers - 20ft and 40ft (6m and 12m)
- On-demand, regular delivery cycle freight and general freight
- Specific routed freight, dry goods and bulky retail goods
The leopard is known for its agility, adaptability and extraordinary carrying capabilities - often transporting prey more than twice its own weight over great distances. Leopards have shorter muscular legs, a longer body and a bigger head than other cats. Black (so called) phantom cats (the rare melanistic form of the Panthera family of cats) have become synonymous in legends around Western Sydney - which is where Camex Transport Services are based.
What types of vehicles do you have?
Camex have semi-trailer trucks, ridged trucks and a utility vehicle with a crane. Our capabilities are summarised on the Services page.
Do YOU DO back-loads?
Yes we do. Camex is always looking for back loads within our operating area.
Yes our prime movers are insured to tow trailers owned by other parties.
Load stabilisers are used to reduce the risk of a load sliding, slipping, shifting or moving during transportation. Camex use load stabilisers that are anchored to the chasis of the truck - this provides a safer way to transport certain loads such as scaffolding, timber and steel.
Confusingly, FTL "full truck load" and LTL "less than full truck load" are terms used to indicate one or both the following:
- Physical capacity: the complete or partial utilisation of a vehicle – by its safe volume or weight capacity.
- Service offering: the purpose or exclusivity of the service being provided.
The physical capacity of a vehicle is self explanatory. With respect to the service offering:
- FTL can imply exclusive use of a vehicle providing services for a single customer.
- LTL can imply non-exclusive use of a vehicle providing services for one or more customers.
Camex offer FTL and LTL services regardless of how you want to define what they are.
History has shown that it is better value for our customers if we use the toll roads in Sydney:
- We do not mark-up toll road charges – they are simply passed on or incorporated into the costs of the service.
- Documentation to support toll road charges can be provided when available.
- We can accommodate requests to avoid toll roads and/or to drive to designated routes.
- A detailed GPS journey/trip report for all of our vehicles can be provided**.
** Note: GPS reports can only be shared in cases where there is no compromise to privacy, security or confidentiality arrangements we have with other customers.
We take our environmental obligations seriously. There are many facets to environmental management in our business and the wider transport industry. Environmental responsibility goes way beyond legislative compliance and reduction of waste in all of its forms - it just makes better sense to run our business more efficiently - this benefits customers and the wider community. Environmental responsibility in our business is not just reducing the impact of noise on suburban streets, always looking for back-loads or investing in modern vehicles that are more efficient and have lower emissions.
We drive trucks efficiently and adjust aero-foils and wind deflectors according to the journey conditions and load being carried. Traffic congestion, scheduled road maintenance and construction is monitored and alternate routes are chosen when possible. Ensuring we drive safely, have safe stable loads and conduct pre-journey risk assessments for all oversize loads plays a big part in us reducing the likelihood of any impact on the environment caused by traffic hold-ups, spills or damaged civil infrastructure.
GPS tracking and journey logging systems provide great information to review if a journey is being undertaken efficiently so that improvements can be made in the future. We use toll roads in Sydney and encourage customers to book services outside peak traffic congestion times when it is convenient for them to do so. We don't hide fuel costs - we use a fuel levy (see below) in our costings and communicate this to customers on request so that they are conscious of the fuel use component in our service.
We have invested in technology to be on the look out for back loads and to reduce the amount of documents we print at our depot and in the field. We have a "buy less packaging in the first place" attitude when buying anything from truck parts to our lunch. We use water wisely, energy responsibly and have a sustainable attitude to rubbish and waste management - targeting everything from sorting our office and general waste for recycling, getting our printer ink cartridges refilled to responsibly recycling steel, engine fluids, tyres and vehicles at the end of their useful life.
Underpinning our safety and environmental responsibility is a keen awareness of the impacts of obsolescence and life-cycle management in the transport industry coupled with our attitude that every little bit counts and that processes need to be regularly reviewed to look for improvements.
Fuel is a significant portion of the total costs associated with providing a road transport service. There are two main variables that impact the fuel cost component of a road transport service:
a. The price of the fuel.
b. The quantity of fuel used.
In relation to these two variables respectively:
a. The market price of fuel itself is typically beyond the control of a supplier or customer
– click here to see recent changes in fuel costs.
b. The amount of fuel used depends on the service provided
– for example metro/out of metro/interstate, size of the load, length of journey, vehicle used, etc.
A fuel levy can be a fair and transparent way of:
a. Protecting a supplier and a customer from rising and falling fuel costs.
b. Ensuring that fuel use is apportioned relative to the service provided.
The Australian Institute of Petroleum - Weekly Diesel Prices Reports are used as an input to our fuel levy calculations. These reports are published here.
Not all invoices include a fuel levy (for example: where a total fixed price for the service, or, a fixed hourly rate for the service has been quoted/agreed). Please contact us if you would like to be sent an information sheet covering details on the fuel levy.
what privacy measures do you have in place?
We only use information provided by our customers for the express purposes of providing a transport service. We do not collect or accumulate data for the purposes of marketing or for sale to any other organisation. Once a financial transaction and/or a business relationship process has commenced there are laws in Australia that govern how long we keep certain information for. Information is held securely and adequate protections are in place - consistent with the Australian Privacy Principles (APPs). We also identify relevant information as COMMERCIAL-IN-CONFIDENCE and include statements about the use of information where it is applicable and appropriate to do so.
To protect privacy online we maintain a SSL certificate for our https based website – this means there is an encrypted connection between your web browser and our website.
How do I get a quote for your services?
Call Paul on 0415 431 408


text:
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"It's not an easy time to be a CISO," according to Ponemon Institute's Dr. Larry Ponemon. Chief information security officers (CISOs) are less confident than ever about data security, with 67% of respondents to a recent Ponemon Institute survey believing their organization was more likely than ever to be hit by a cyber attack or data breach.
CISOs cited a "lack of competent in-house staff" as the most likely reason for a data breach. Respondents also pointed to:
- The inability to protect sensitive and confidential data from unauthorized access (59%)
- The inability to keep up with the sophistication of criminal hackers (56%)
- Failure to control third parties' use of sensitive data (51%)
"Data breaches and cyber-attacks continue to plague organizations and the responsibility of protecting sensitive data stops with the CISO," said Dr. Ponemon. "It's critical that companies support CISOs and reduce risk by implementing standard processes, including policy review and documentation, senior leadership and board member oversight, as well as other safeguards to reduce their vulnerability."
Invest in your staff
When senior managers are told that they need to improve their organization's cybersecurity, they might immediately turn to technological solutions. However, Ponemon Institute's study indicates that organizations need to address employees' ability to avoid, identify, and respond to cyber incidents.
IT Governance offers a variety of staff awareness training courses to help employees prevent cyber incidents. By educating staff through training courses, tools, and thought-provoking activities, we help them understand the risks they face and advise them on the ways they can stay secure. Our courses cover many topics, including phishing, ransomware, and ISO 27001.
When implemented alongside technological defenses and effective security policies, staff awareness training can drastically reduce the likelihood that your organization will fall victim to a data breach or cyber attack.


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WINCHESTER, Mass. – It was tough sledding for the Johnson & Wales University men's tennis team on Sunday. The Wildcats dropped an 8-1 decision at Emerson.
Johnson & Wales dropped to 1-2 while the Lions evened their record at 1-1.
JWU almost salvaged a win in doubles, but Joseph McGuigan and Brandon Case lost 8-5 at number three. The Wildcats' lone win of the day came at number four singles where Franz Fonck won 7-6, 6-3 over Brock Higley.
The Wildcats wrap up the fall season next Sunday at Salve Regina.
Oct. 7, 2018 at Winchester, Mass.
Emerson 8, Johnson & Wales 1
Singles competition
1. Bass Linn (EC) def. Will Lyons (JWU) 6-1, 6-0
2. Maximo Lawler (EC) def. Alexander Rohana (JWU) 6-1, 6-2
3. Dan Okin (EC) def. Steven Heizler (JWU) 6-3, 6-2
4. Franz Fonck (JWU) def. Brock Higley (EC) 7-5, 6-3
5. Bernardo Garza (EC) def. Robert Michalofsky (JWU) 6-0, 6-3
6. Shawn Lee (EC) def. Brandon Case (JWU) 6-3, 6-2
Doubles competition
1. Bass Linn/Dan Okin (EC) def. Alexander Rohana/Franz Fonck (JWU) 8-1
2. Maximo Lawler/Brock Higley (EC) def. Will Lyons/Steven Heizler (JWU) 8-3
3. Brandon Garza/Shawn Lee (EC) def. Joseph McGuigan/Brandon Case (JWU) 8-5
Match Notes:
Johnson & Wales: 1-2
Emerson 1-1
Order of finish: Doubles (2,1,3); Singles (1,2,3,6,5,4)


text:
Friday, April 16, 2010
In Which Dora Teaches Us a Lesson
After watching Star Wars over Christmas break when he was in the first grade, my son decided he wanted to be George Lucas when he grew up. He made his first movie on the last day of Christmas break.
At first I thought it was a joke. He came to me and said he wanted to make a movie. I was busy so I told him he needed to write a script first, thinking this would be too much work and he would find something else to do. He was back fifteen minutes later, script in hand. So the four of us spent the afternoon helping Drew make his movie, The Lonely Jaguar.
Soon after we discovered a stop-motion animation program for the Mac. Drew became obsessed. He was constantly making movies with his Star Wars toys. He and Jasmine filmed a Dora movie, a NASCAR short and a bunch of other stuff that we've never posted.
The video above was made back in January 2008. A few weeks ago, Drew started his own YouTube channel. Most of the videos on his channel are Star Wars/Clone Wars stories that he has written himself. He monitors followers and video views as carefully as some bloggers watch their SiteMeter stats. (You can watch his more recent videos here.) Trust me -- he'll notice and he'll be thrilled to see that more people have watched his videos :)
When this whole movie making thing first started, I was constantly being roped in to help, first with filming, then with editing. These days, he does everything on his own. Which is why, every weekend I surrender my computer and my dining room. While I clean house or read a book, my son is making movies, working toward his dream.
I'll admit it. I swell with motherly pride that he's willing to invest so much time in something that he is so passionate about. It also kicks my butt in gear and makes me want to work harder for my dreams, too.
Today I challenge you. We know it isn't all fun and games. It takes a lot of work. So do the work and make your dreams come true.
23 comments:
- Kelly Polark said...
Wow! That was SO creative. I watched it with my five year old. Afterwards he yelled, "Again! Again!" So we watched it again.
What equipment do they use to do this?
Your kids (and dog) are adorable (and smart!).
- April 16, 2010 at 7:00 AM
- Sherrie Petersen said...
Cool, Kelly! I'm glad he liked it!
- April 16, 2010 at 7:15 AM
- Unknown said...
That's so sweet of you, Sherrie. My 7 yo keeps talking about making a movie, but I think he's talking something more like a Disney digital animation. And I don't see that happening. I'll show him your son's video tonight.
Have a great weekend!
- April 16, 2010 at 7:26 AM
- storyqueen said...
Wow! I am certain Drew will achieve his dream.
Just blown away.
- April 16, 2010 at 7:28 AM
- Anna Staniszewski said...
That's wonderful that he's so into it, and that he's learned to do it all himself! Very impressive.
- April 16, 2010 at 7:29 AM
- Lydia Kang said...
That is pretty awesome. A future Spielberg in the making!
- April 16, 2010 at 7:52 AM
- lotusgirl said...
Amazing. Talk about some great initiative.
- April 16, 2010 at 7:57 AM
- Laura Pauling said...
That's really cool! Obviously the creative bug runs in the family.
- April 16, 2010 at 8:13 AM
- Sarah Laurenson said...
This morning, I was contemplating doing something like this myself, but it's not where my interests really lie. I'm glad he's pursuing his dream. That's so awesome.
Will check them out later today.
- April 16, 2010 at 9:05 AM
- Roxy said...
You are an awesome mom, and it shows in the great kids you have. Excellent post. I needed a reminder like this to kick my buns into gear.
- April 16, 2010 at 9:55 AM
- Candyland said...
Definitely cultivate that talent! How freakin'adorable!
- April 16, 2010 at 10:03 AM
- Corey Schwartz said...
Wow! I am SO impressed! What an amazing kid! I love your son! (maybe he wants a cute six-year-old blogger girl friend? :)
- April 16, 2010 at 10:47 AM
- Elana Johnson said...
What an inspiration. I'm emailing myself the link because I can't watch videos at work.
- April 16, 2010 at 12:13 PM
- Carolyn V. said...
That is very cool! So great he is starting now. =)
- April 16, 2010 at 1:03 PM
- Sherrie Petersen said...
Stina: I think that's what Drew had in mind originally, but he's learned to make do with what he can!
Shelley: He inspires me to dream big every day!
Anna: He knows far more about it now than I even did back when I was helping out. But it's his passion so he works at it.
Lydia: Yeah, Spielberg, Cameron and Lucas are his heroes!
Lois: He's a very self-motivated kid. Keeps me on my toes!
Laura: My husband is an artist: painting, drawing, ceramics. So yes, we do all have our creative outlets in this family!
Sarah: That's the thing -- pursue the dream!
Roxy: Thanks! My kids do inspire me every day :)
Candy: Yes, we're realizing we need to save our pennies so he can go to film school!
Corey: LOL! He would probably love a blog buddy. But he still thinks the idea of a "girl friend" is gross :)
Elana: Hope you enjoy watching them!
Carolyn: No kidding! I'd be so much further along if I'd followed my passion from childhood!
- April 16, 2010 at 1:08 PM
- Kristin said...
I'm so impressed!!!! I need to show my boys this. They will love it!
That's the thing about kids, they don't have the doubts and fears that plague us as adults. They just go for it. Thanks so much!
- April 16, 2010 at 2:43 PM
- Rena Jones said...
My boys loved that! They laughed when the cat meowed. We'll have to check out his other movies. My boys and oldest daughter love making these too. They're working on one right now -- something about GI Joe and aliens.
Tell your kids great work!
- April 16, 2010 at 8:06 PM
- Jackee said...
So very amazing! That says a lot of about your parenting, Sherrie, that he's confident enough to work toward his dreams at such a young age.
Can I request he do a Thomas the Tank Engine one? I have a three year old that will be his biggest fan forever if so! (We have to spend way too much time looking at other amateur TTE creations on Youtube, so a new source would be appreciated! LOL!)
- April 16, 2010 at 9:49 PM
- Michelle D. Argyle said...
I am seriously in awe! There is no way I could have done something like that as a kid, even with the technology. That's a lot of work!
My daughter just sat and watched the video. She was captivated the entire time, no joke. Tell your children they do a great job!
- April 17, 2010 at 7:57 AM
- Lori W. said...
I love the part where Dora suggest, "We'll put tape on our shoes." That's so how kids think with their creative problem skills. Way to go, Drew! I'll show this to my son who is already a fan of many stop motion vids. on You Tube.
- April 17, 2010 at 8:58 PM
- lisa and laura said...
I AM BLOWN AWAY! It's no surprise that your kids are creative (I mean, look at their mom), but they're SO young! And adorable. I want to eat them up! Thanks for sharing this...I'm amazed!
- April 18, 2010 at 5:23 AM
- Sherrie Petersen said...
Kristin: You are so right! I think we need to remember to go for it. Hope your boys enjoyed the videos :)
Rena: GI Joe and aliens sound fun!
Jackee: Drew used to LOVE Thomas! Not sure if we still have any trains around though :)
Glam: I'm so glad that your daughter enjoyed watching the video! My kids have a blast making them and they love when other people enjoy watching them.
Lori: You're right -- that's the perfect example of childhood problem solving :)
LiLa: I'm pretty sure my kids are more creative than me. They're certainly more patient -- stop-motion animation takes a LOT of time. But they love doing it so to them it's just fun!
- April 18, 2010 at 7:45 AM
- Unknown said...
I love how you encourage your children to be creative. It is fabulous!
- April 21, 2010 at 7:26 PM


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Every year parents would consider if their child will be ready for a smartphone. There is plenty of smartphone for kid's options in the market.
However, most of them do not have parental control installed and guidelines given to them.
As a result, there are increased incidents of bullying, depression, and sextortion.
While a mobile phone can be a great gift with plenty of educational and entertainment opportunities, it can open them up to a world that they may not be ready for it.
Don't forget to download the smartphone self-evaluation toolkit for your kids
Once you give your child a smartphone there is no turning back. So before buying them a phone, ask yourself the following questions:
Knowing why your child wants a phone will give you an insight into their actual motive for wanting a mobile phone.
Is it because they want to use a certain app that their friends are using? If this is the reason then find out what the app is about and see if it is age-appropriate for your child- you do not want to hand over a phone to them just for the same reason they are not allowed to use it.
If you think your child is too young for this conversation then they are not ready for a phone.
The internet has made it easy to access pornography. A new report suggests that children as young as 8 years old have admitted to being addicted to internet pornography.
If you are going to give your child a mobile phone you need to be prepared that at some point they will most likely stumble on porn websites, even when you have parental control switched on. Inappropriate content always finds a way to slip through.
Here are few tips to help you talk to your tween about online pornography
Social media has taken cyberbullying to an increasingly dangerous level. Children as young as 11 are feeling suicidal because of bullying. Only one in 10 victims would inform their parent if they are being abused online.
10-year-old Ashwanty Davis committed suicide after a video of her fighting with an alleged bully was uploaded online.
Parents have a conversation with your child about cyber-bullying, why is it harmful to do this on someone else and what to do if it happens to your child.
You need to speak to your child about suicide and let them know what they can do if their friends are feeling suicidal.
It is important they know to never encourage anyone to harm themselves even though they were "just kidding" about it.
The CDC reported that suicide rate has increased by 30% for teenage boys. For girls between the age of 10 to 14 years old, it has tripled over the last 15 years.
With so many children dealing with mental health issues, giving unsupervised access to a smartphone can exarcerbate the situation.
If you think your child is not ready for such a conversation, then do not give them a phone.
Sexting is sending sexual text and images to another person.
In Scotland, if your child is below the age of 18 years old it is considered an offense to send and distribute nude images.
It is crucial that parents understand that sexting is common among teenagers. A study conducted by Pediatrics found that one in five children between the age of 10 and 15 years old are sexting.
Let your kids know that once an image is sent, it can never be taken back. If a message goes viral it can follow your kids for many years to come.
If you think you are not ready to talk about sexting to your child then delay giving them a phone until they are ready for such conversations.
Inform your kids about the possibility of encountering strangers online. Let them know that people online tend to pretend to be someone they are not.
Predators pose as teens on social media. It is easier for them to meet kids and groom them. The tactic they use is by complimenting your children constantly and flattering them.
Once, they built trust with kids, predators manipulate kids into sending them naked pictures of themselves. They can then demand more pictures with the threat of exposing them.
According to an ABC report, "one in five kids aged 10 to 17 reported they had received unwanted sexual solicitations online, ranging from sexually suggestive comments to strangers asking them to meet them in the real world for sex."
Equip your children with safety precaution measures. Instead of telling them not to talk to strangers, let them know the reasons behind it. Show them articles and videos of how sexual predators target children. Telling them that there are monsters behind the screen is not comfortable for many parents. But if you want to give them a smart phone then you cannot ignore this topic.
Make your child understand the purpose you are monitoring them is not to spy on them but rather to protect them from some of the online dangers explained above.
Using parental control apps you will be able to keep an eye on what your kids are doing and whether the rules imposed on them have been followed through.
A phone contract can help your kids understand the rules that come with owning a mobile phone. They will be liable if they break any of the rules.
The contract should be written and agreed upon before buying the phone. Here is an example of a family media contract.
A list of rules would be included in the contract, such as :
Instead of just printing and signing a ready-made contract template, customize it based on your priorities. Sit with your child and negotiate the contract together. This will help kids understand the significance of the contract and what is required of them.
Mistakes are bound to happen, regardless of the number warning and reminders about online safety you can put in place. Yet, it is important to talk about what they can or cannot do online.
Here are some NO's your children should know about :
If your child is below the age of 13 years old they should NOT be on any social media platform including WHATSAPP.
If your child is above the age of 13 years old then talk to them about social media etiquette.
Here are few tips to get the conversation started :
Keep yourself updated with the latest digital trends by Subscribing to us at the bottom of the page
Great tips. As a mom of two teenage boys, it's very important not only that they consent to being monitored but that parents remember to continue to monitor their phones and talk to them about what we see.


text:
On Saturday June 13, 2015 Brothers Lungisa and Gary headed out to evangelise at the secular music concert taking place at The Oval in Alexandra Park, Pietermaritzburg.
This music event was usually held on the last day of the Royal Agricultural Society (RAS) Show being the tenth day. However, this year the music concert was not held as in the past and even though Ukhozi FM and the RAS had advertised in the media that the date had been changed, huge crowds of "concert-goers" still came out in their masses on Sunday June 7, 2015! As over the years a huge street party ensued with much drinking, debauchery and crime being the order of the day.
In 2013, Lungisa and Gary had made a video warning of the under-aged drinking of alcohol by school children and even with the presence of the SAPS and the Msunduzi Traffic law-enforcement officers, crime was out of control. Back then there were criminal activities taking place in broad daylight and nothing was done about it. It was just a matter of time for the criminal activities to get out of control. And so it was on Sunday June 7, 2015 at about 18H00 with the "street party" unsanctioned by RAS and Ukhozi FM and therefore not "supervised" by law agencies, drunkenness spilled over into, what was reported as, gang related violence on an old horse polo field and a 19 year old fatally stabbed a Mooi River young man named "Themba" multiple times! Another murder had taken place upon the streets of Pietermaritzburg at a "fun-event"! The reports can be read Here (The Citizen) and Here (Public Eye Maritzburg).
From our + 5 hours ministering out there on Sunday, the crowds coming to the event were "much better" behaved than the total abandonment that we have seen at past events. However, there was still alcohol consumption and a few drunk children that we saw and heard. It could also be the case that they were "partied-out" from last week, but the crowds picked up steadily during the morning and early afternoon. Hundreds of Gospel tracts were handed out, some conversations had and the Name of our Lord and Saviour Jesus Christ was proclaimed and high and lifted up! We have a three part part-open-air preaching by Brother Lungisa in isiZulu before the battery on our camera died!
Part 1:
Part 2:
Part 3:
Kindly keep all in your prayers of those who had an ear to hear the Word of God and that our Great God and Saviour Jesus Christ would have saved the elect this day!
Soli Deo Gloria!
Filed under: Evangelism, Events, Videos | Tagged: Gospel of Jesus Christ, Gospel tracts, Law and Gospel, Law and Grace, Open-air Preaching, Repent and Believe South Africa, Ukhozi FM |


text:
Sibling duo Harlequin Gold turned tragedy into a career with new EP.
Harlequin Gold
When: Nov. 29, 8 p.m.
Where: The WISE Hall, 1882 Adanac
Tickets and info: From $20 at ticketweb.ca
Harlequin Gold is fronted by Kelowna-raised sisters Elle and Avery O'Brien. The group released its four-song debut EP Baby Blue earlier this year to universally positive reviews, with songs such as Take Me Home grabbing ears across Canada and down the U.S. west coast.
The working lineup of Avery on bass, keyboards and vocals, with Elle on guitar and vocals, producer and guitarist Justice McLellan, and drummer Jamison Ko came together about a year ago.
Elle O'Brien is quick to note that the connection to music for both sisters is a "lifetime" thing and the two grew up singing and writing songs together, but they had not planned on coming together in a band.
A few years back, Elle was a microbiology graduate contemplating dentistry and Avery was "studying coffee," working as a barista in Melbourne, Australia. When their brother had a life-threatening dirt biking accident and wound up in a coma, Avery came home and the family united to face an uncertain future.
During this difficult period, the siblings concluded that they wanted to make music together again — it was one of the only things that really made them feel OK in that very hard time. Once that choice was made, things started to move.
"I met Justice at Zulu buying tickets for a Canada Day party at the Waldorf and asked him if he was coming," said Elle O'Brien.
"After that, we kept on running into each other, in East Van, at the park and so on. After about the eighth time, we decided to go for a drink and that's when I discovered he was involved in music, and he immediately fit right in with what we were doing music. Now he is over for family dinners all the time."
McLellan produced the fist two DIY recordings by Harlequin Gold. Recorded in an apartment, Without You Now and Youth both were hits on Spotify. This early positive fan response lead to the decision to become a full band. In short order, the group was getting good opening gigs with bands such as Sunflower Bean at Canada Music Week in Toronto.
"I was working on a solo, electronic EP project," says Elle. "But I didn't really have the drive to do it, because singing with Avery just felt so much better and natural. I can't imagine making music any other way now, actually."
Produced by McLellan, with input from Mark Needham (The Killers, Imagine Dragons), John Raham (Dan Mangan, Frazey Ford), and Stephen Marcussen (Paul McCartney, Band of Horses), the Baby Blue EP is most certainly not an electronic-based effort. The closest comparison would be what Metric might sound like with two female voices.
From the title track to the hook-filled natural breakout single, Take Me Home, the recording is loaded with intricate and atmospheric guitar and a stripped down and driving rhythm section, all buoyed by the sisters' complimentary harmonies.
The dual vocal interplay is the standout quality of the EP, and one that both singers admit has long been in the making.
"Even before we were singing or writing together, we were always singing and harmonizing other songs," said Avery. "It would drive our mother nuts driving in the car as we would start harmonizing to whatever was on the radio, really badly. Nobody ever sang the melody or the lead, we both just kept trying to find interesting ways to harmonize around the music."
Without question, the sisters found their spaces within the songs. From the almost early folk duets in the title track to rising arena hooks of Want You More and the natural singalong chorus in Take Me Home, the EP is full of accomplished musicianship. The catchy pop got noticed well outside the Vancouver indie scene, leading to the band getting work in the U.S. and dates in Australia for the Big Sound festival.
"Greg Little, who is a booking agent out of Atlanta, heard Take Me Home somewhere online and went out of his way to find us," said Avery.
"He believed in us right away, and wanted to help getting U.S. work visas and setting up the coming shows in Seattle and Portland. It's pretty exciting for us, because there are so many places to play down the coast."
Both sisters are pumped to pursue all the international opportunities available to them, with a plan to hit somewhere in the U.S. every 45 days (as the work visas permit) to build a following. The Baby Blue EP is best viewed as a calling card, as the siblings say that they are sitting on enough finished songs for a full-length album and can easily fill a headlining set.
"We have a good dozen songs we've locked down as a band and another section that just need to sort out the keyboards for," said Avery.
"The idea is to put it between Elle and Justice as she is right-handed and he is left-handed and maybe they can play it with the free hands, upside down and backwards."
So it's a typical case of tour and build a market for your music facing Harlequin Gold. In keeping with the nature of how music is consumed today, the members are able to chart where the streams are coming from and use that to determine where to play. It seems pretty certain that Europe is on the list. Both musicians admit that it's very interesting looking at the metrics behind the music streams, gleaning information ranging from gender to location of fans.
"Europe is where we have the greatest number of streams at the moment, by far," said Elle. "Specifically, in Germany where we are looking at 60,000-plus streams compared to a tenth of that in all of Canada. The cool thing about social media is that your music can travel so much farther and can find fans and you can decide what to do with that information."
Elle says that she writes "in clumps," usually in the morning, which "probably drives the neighbours nuts." But lately, a lot of the songwriting process is pulling ideas out at band practices and working on them as a whole.
"It's pretty awesome how our singles have shown the different influences coming into the band, from Justice's rock style to Jamison's jazz and Avery's indie rock and my ideas," said Elle.
"There is a lot of blending genres, from I Was Your Girl's folk-pop to Take Me Home's indie rock. One of our friends stalks us on the internet and says that it's hilarious how often the genres we are listed under change."
As long as the comments pronounce the songs as good, Harlequin Gold is ready to shine anywhere the music takes them. The band maintains a rigorous release schedule of performance videos, and keeps fans engaged across social media platforms.
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