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Beef Bulgogi Soft TacosÉté 2012
Beef Bulgogi Soft TacosÉté 2012
BY: Christopher St. Onge
L.A.'s Kogi Barbecue first introduced the world to tacos with a Korean twist, cleverly using Twitter to announce its trucks' locations. The rage for its playful treats shows no sign of slowing any time soon. Our own version is packed with juicy grilled steak, refreshing cucumber and sweetly addictive spice.
While common pantry items in Korea, both the kimchi and the gochujang (a spicy-sweet chili paste used extensively in Korean cuisine)will require a visit to a well-stocked Asian grocer.Try the chili sauce tossed with deep-fried chicken wings too.
3 tbsp (45 mL) soy sauce
1 tbsp (15 mL) mirin
1 tsp (5 mL) sugar
2 tsp (10 mL) black sesame seeds1 clove garlic, finely chopped1 lb (500 g) boneless beef short ribs, cut into ¼-inch-thick (5-mm) slices
1/3 cup (80 mL) gochujang
¼ cup (60 mL) unseasoned rice vinegar
1 tbsp (15 mL) soy sauce
2 tbsp (30 mL) sugar
1 tbsp (15 mL) sesame oil
3 green onions, finely chopped
½ cup (125 mL) mayonnaise
2 cups (500 mL) shredded iceberg lettuce
½ cup (125 mL) chopped cabbage kimchi
Juice of 1 lime
8 small flour tortillas1 cup (250 mL) thinly sliced cucumber
1 For the beef, combine the soy, mirin, sugar, sesame seeds and garlic in a large mixing bowl.Add beef and toss to coat. Allow to marinate for at least 1 hour, or overnight in the refrigerator.
2 To make the chili sauce, combine gochujang, rice vinegar, soy, sugar and sesame oil.Whisk until sugar is dissolved.
3 For the green onion mayo, combine onions and mayonnaise.
4 When ready to serve, heat barbecue to high. Combine iceberg lettuce, kimchi and lime juice. Grill beef 1 minute per side for medium rare. Remove to a cutting board and chop into strips. Slather tortillas with the mayonnaise, divide lettuce mixture and beef between them and top each with several slices cucumber.
Drizzle with chili sauce.Serves 4


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Last meal for The Monster on the Lima one day eating express is Central. This hip bar and sophisticated restaurant hidden behind a door with no sign attracts the crème de la crème of Lima and an international clientele. An argument can be made it is the number one restaurant in the city at the moment.
It's a beautiful room filled with even more beautiful people. Glancing at the menu this may be an all-time classic, it's both accessible and innovative and filled with Monster favorites. As Nina Simone croons, the last (okay, there may be one or two more) Peruvian cocktails is happily coiffed.
Getting down to business, because The Monster is exhausted, here's the good work for the evening:
Lines of scallops, tuna, cocona, sweet potato, Umami Sea. The sashimi course falls a bit flat. The fish is fresh but nothing about the taste wows.
Hot ceviche, langostinos, corvina, charcoal, araza. Proves the existence of heaven. Hyperbole perhaps? Not a chance, it's that good.
Charred purple corn-scented octopus, lentils, olives, sprout, scallions. Coming off the high of the last dish this merits a notch less on the wow meter. The octopus is perfectly presented, the sauce leaves a bit to be desired.
Roasted grouper, huamantanga potato, calamari, black quinoa, confit of greens. Simple, flaky, delicious.
Lastly, some sweets as compliments from the house.
Service is exceptional. Friendly and unobtrusive but exceedingly professional. This is a serious restaurant where the entire oeuvre is tasked with reaching perfection. As the final meal in Lima it is a fitting send-off from a country with wonderful sights, friendly people and seriously fantastic food.
Why go? Nirvana is a day of eating at La Mar, Astrid Y Gaston and Central.
Monster rating: 4½/5 Monsters
Calle Santa Isabel 376 | Miraflores, Lima LIMA 18, Peru

subset: commoncrawl


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Licensed States
- Alaska Marijuana Laws
- Arizona Marijuana Laws
- Arkansas Marijuana Laws
- California Marijuana Laws
- Colorado Marijuana Laws
- Connecticut Marijuana Laws
- Delaware Marijuana Laws
- Florida Marijuana Laws
- Hawaii Marijuana Laws
- Idaho Marijuana Laws
- Illinois Marijuana Laws
- Indiana Marijuana Laws
- Kansas Marijuana Laws
- Kentucky Marijuana Laws
- Louisiana Marijuana Laws
- Maine Marijuana Laws
- Maryland Marijuana Laws
- Massachusetts Marijuana Laws
- Michigan Marijuana Laws
- Minnesota Marijuana Laws
- Montana Marijuana Laws
- Nebraska Marijuana Laws
- Nevada Marijuana Laws
- New Hampshire Marijuana Laws
- New Jersey Marijuana Laws
- New Mexico Marijuana Laws
- New York Marijuana Laws
- North Carolina Marijuana Laws
- North Dakota Marijuana Laws
- Ohio Marijuana Laws
- Oregon Marijuana Laws
- Pennsylvania Marijuana Laws
- Rhode Island Marijuana Laws
- Texas Marijuana Laws
- Vermont Marijuana Laws
- Virginia Marijuana Laws
- Washington Marijuana Laws
- Washington, DC Marijuana Laws
- West Virginia Marijuana Laws
Medical (Comprehensive)
Important Dates
2004: Medical marijuana was legalized
2011: Lawmakers attempted to repeal the legality of medical marijuana; however, the Governor vetoed the repeal and instead, substantial restrictions were put on the state's medical marijuana program
2016: Bill I-182 was passed removing many medical marijuana program restrictions
2017: SB333 was signed which added mandatory testing, seed to sale tracking and new tax regulations to the medical cannabis industry
In 2004, the Montana Medical Marijuana Act was approved by 62% of voters. In 2011, lawmakers attempted to repeal the law; however, the Governor did not sign the appeal. Instead, a bill was passed and new provisions were put into place that made it extremely hard for medical marijuana patients to gain access to medicinal cannabis. For example, providers could only service three patients at one time and any doctor who recommended medical marijuana more than 25 times in one year could be audited by the state medical board. In 2016, Bill I-182 passed and amended the strict medical marijuana laws in Montana, expanding the list of qualifying conditions, allowing providers to service more than three patients and establishing licensing procedures for dispensaries. In 2017, SB333 was signed into law, adding mandatory testing, seed-to-sale tracking and new tax regulations to the industry.
Can I possess, buy or grow marijuana in Montana?
In Montana, Cannabis is legal for medical usage only. Medical marijuana patients can possess up to an ounce of medical marijuana and can grow up to four mature plants or 12 seedlings on private property if they do not designate a provider. Qualifying conditions include, but are not limited to:
- Cancer
- Chronic pain
- Seizures
- Nausea
- Glaucoma
- Crohn's disease
- Post Traumatic Stress Disorder
Punishment for the possession, sale and cultivation of recreational marijuana is extreme. A first offense possession charge can result in six months in prison. Sale and cultivation carry even higher levels of punishment.
Can I operate a vehicle while under the influence of marijuana in Montana?
It is illegal for patients and non-patients to operate a vehicle under the influence of a drug, including marijuana.
How do I get a medical marijuana card in Montana?
In order to obtain a medical marijuana card in Montana, you must submit a photo of the registrant, a photo ID (Montana license, passport, Montana state ID), the appropriate application papers, a doctor's recommendation and a fee of $30 to the Montana Department of Health and Human Services. Applications are processed in the order they are received.
Can I use marijuana in public in Montana?
Rules regarding smoking marijuana in public in Montana are vague; however, the law currently prohibits smoking on school grounds, in public parks, public beaches or recreation centers and in correctional facilities. In order to avoid fines and jail time, it's advisable to only use marijuana on private property.
Can I sell marijuana in Montana?
Only licensed providers may sell medical marijuana in Montana.
The information presented here should not be construed as legal advice. State and Federal laws are always subject to change. We aim to keep this page as updated as possible; however, for additional information regarding Montana marijuana laws, please see Find Law and the National Conference of State Legislatures.


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OAI has a long history of working with sports facilities, creating a total fan experience both inside and outside of each property. In addition to designing graphics that fully brand a stadium or arena by optimizing every available space, OAI also offers a variety of products that can be used to increase sponsorship benefits and therefore profitability.
Some of OAI's products that are typically utilized for sports properties and facilities include:
Fence Mesh, Scoreboard Signage, Hall of Fame Signs and Plaques, Wall Murals, Field Walls, Seat Covers, Field Stencils, Window Graphics, Stair Graphics, Windscreens, Tunnel Covers, Field Tarps, Directional Signage, Menu Boards, Sponsorship Signage, Magnetics, Custom Architectural Signs, Channel Letters (front lit, reverse & dual lit), Fabricated & Dimensional Letters, Single & Double-Faced Sign Cabinets, Routed & Backed Signs, Large Format & Flat Bed Digital Printing, Vinyl Lettering, Vehicle Wraps, Banners, Routed Signs, Architectural Lighting, Directional Signage, Interior Signs, Regulatory Signs & ADA Plaques, Pylon & Monument Signs, Canopy Signs, Wayfinding & Campus Signage Programs, Environmental Graphics & Branded Environments, Permanent Structural Signage, Temporary Decals & Magnets, Multi-Purpose Window Film, Decorative Wall Murals


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Search the Community
Showing results for tags 'responsive'.
Found 32 results
cazbart posted a topic in BT Simple Slideshow moduleHi - I wrote the following yesterday but found out that it is the Purity Template hiding the slideshow - all fixed thank you Cazbart I am happy with the slideshow but it is disappearing when my tablet is on portrait and when my android phone is either landscape or portrait. Are there any settings I need to change to achieve the slideshow on these important devices. I chose it because it was responsive and is working on the tablet in landscape. Advice please? Cazbart
mbrown posted a topic in BT Content SliderHi Is it possible to reduce the number of columns (and rows) displayed when the screen size is reduced (eg from desktop screen to narrow mobile screen?) I'd like to show 4 or 5 columns on the wide screen with the left & right navigation arrow, but on a mobile, one column (or 2) as long as it still fits in 1 row would do, instead of having 4 or 5 rows to show the 4 or 5 articles. Thank you
Daniel posted a topic in BT Shortcode PluginDear Support Staff, I'm using your plugin really much and like it. On a mobile device it looks great so far, the only thing I recognized there: Columns are not working that well. For example: I choosed a 2 column layout and on an iPhone Portrait View this layout is still visible (2 columns), but it looks not nice and you can't read the text very good. How can I get this responsive as well? I think I have to do something with the class "bt-column col-xs-12 col-sm-6 col-md-6 col-lg-6" ... EDIT: Maybe I have to add that it seems only to occur in combination with Iconbox tag. Means: First I create 2 columns layout, then within each I added an icon box. Thank you very much in advance! Best regards, Daniel
mschnyde posted a topic in BT FitnessHi, How can I resize the logo, which is upper left hand side for mobile (i.e. iphone 5) view? Currently it's to big on mobile. Kind regards, Marco
Philippe posted a topic in BT Mobile AppsHello, I talked to your customer service through chat and they told me that you could help me with this issue: I am making a responsive website and I chose BT login as this is the best extension I have found for login: beautiful! Normally this module would not really need to be responsive as it is small, but in my iPhone, it is still a tiny bit too big. I would like to know how I can adapt the module's size - concretely the popup window's size - in order to fit the iPhone's screen. Maybe it's possible via css? Thank you in advance for your help and best regards, Philippe
Imago SRLS posted a topic in BT EducationHello guys, In my website we have two main formats for pictures of the k2 articles, as you can see on the home page: one vertical (no-featured); one horizontal (featured). I'm trying to improve the article view, currently It looks like this: Online see For the "featured item" (vertical image) the displaying is ok (online see), but for other view we would something like that: Is possible to make this improvement for the featured articles? Thx
Bill Bateson posted a topic in BowThemes Forum RulesHi, I am having issues with BT Slideshow Pro responsive slider. The slider doesnt seem to load until you resize the window. Could you please let me know how can this be fixed ASAP please. Thanks.
Imago SRLS posted a topic in BT EducationHi to everybody, is possible to make the mobile view responsive? I would like to have the articles divided into two columns in the desktop view and in a single column in the mobile view. Thanks for the help Matteo
Alvis posted a topic in BT Content SliderTeam, I recently installed the content slider. It looks good on desktop view. However, when I view on mobile, it only comes up in 1 column only. This leaves a lot of white space :( I would like the slider to show more than 1 column when viewed on mobile device. Please check attached image
Pelle P posted a topic in BT Slideshow ProHi support I love your module but I have a little problem. When I resize the module, the caption area totally dominates the picture. Is there a fix for this? Maybe a special responsive style or a way to hide the caption, when you down size... See picture... Best Regards Pelle
rumovantagem posted a topic in BT Real EstateHello, I'm using BT Real Estate Template and I need your help with my website on mobile view! I desabled the responsive mode, because I want to see my website on mobile with the same view as I see on my desktop. I send you one example of a website made by us with the mobile responsive desabled but with the same view of the desktop (what I want with the Real estate template) What can I do, in order to do that?
webmaster posted a topic in BT Content SliderHii My content slider works very well in my site, but in mobile device the thumbnails get fixed positions over the site page and the slide doesn't look good. What can I do to fix the problem?
DeusLove posted a topic in BT PhotographyHello, can you help me with some questions^ 1) How to turn off the mobile version of template 2) How to turn off the Responsive for tablet and phone - or how to do so, that on the PC, phones and tablets worked only PC version of this template?
mikoarts posted a topic in BT Content SliderHi - I'm almost done with getting this great extension to work exactly the way I need. One thing - I thought that this was a responsive module - Because it's probably the absolute best module I've found which is performing its task, I'm going to keep using it regardless of this outcome, but I still want to ask: It's not responding to changing browser width(s) or Firefox responsive design view. Is this normal or is it a result of CSS modifications I've performed on it? Whatever you can offer as advise for me to try is greatly appreciated! Thank you in advance!
Mooner Man posted a topic in BT Content SliderHello! I'm using BT Content Slider on a responsive theme. The module containers sizes changes for different screen size (from 600x600 down to 300x300 and then down to 150x150). If I put the width of BT Content Slider to Auto, long titles won't wrap in the maximum size, if I give 600px width, then in smaller sizes it won't work (The words will go out side of the module area! so some of the text is not shown.) How can I set it somehow to took all the module space and in smaller sizes automatically respond to new size?
chris posted a topic in BT Slideshow ProHi all, I'm having an issue with this module on iPad and iPhone devices. The text on the banners overlaps the next one. Please have a look at the attachment. Thanks
doriz posted a topic in BT Social Sharing PluginHi, I just read your plugin can make button responsive but i can`t find the option for responsive... thank alot.
Dr. Jochen Papasokra posted a topic in BT Social Sharing PluginHi, i am using the BT Social Share plugin long time now, because it was the first Extension with responsive display. Now since a few weeks the display doesnt goes anymore over the full with of the article. The funktion Responsive doesn't work. The with is setted to auto. Any solution for that? (http://www.ahornevents.at/kuenstler-bei-ahornevents/juan-carlos-l%C3%B3pez.html or http://www.webelegance.eu/departure-abfahrt.html) . Thanks for help! Gerald
Mis Recursos posted a topic in BT Content SliderHello, first of all congratulate you for such excellent extensions. I run into a problem, which is that by creating either a single item or k2, the images are overlaid on the content. I tried to include images in the content of the article, the image upload tool independent ... but I have not been successful. Also try changing the module parameters settings, activating and deactivating plugins, modules, etc ... but neither fuciona. I have also followed the steps in the user guide, but not if the problem is in the way the items are created. Deputy screenshots The URL where I am doing is testing: www.mpradaestudio.com/clientes/cootracar/ I appreciate greatly your help to solve this problem and make the content look like in the demo. I am very attentive to your response!
An posted a topic in BT E-commerceHello! Using this template for a client and when reviewing template on iPhone, the template is very off for some elements. 1. The search button is not aligned correctly. 2. The images used in K2 items are not rescaling to size of window. 3. The "Like Us Facebook" is not scaling images either for both computer window and iPhone window. While the site is in development, you can view it from this link: http://scabib.com/joom/ Thanks for your help and hope it comes quickly. An :)
Manuel posted a topic in BT TravelHello! I would like to have left - content (main) - right instead of default-content-right /left. I searched in the documentation, but could not find a way. I remember there was an option in the old BT Travel version: <?xml version="1.0" encoding="utf-8"?> <layout name="desktop"> <!--Extra css load for this layout--> <stylesheets> </stylesheets> <blocks name="top" style="xhtml"> <block name="absolute" type="modules" style="raw">absolute</block> <!-- <block name="mainnav" type="mainnav" main-inner="1"></block> --> <block name="header" type="header" main-inner="1"></block> <block name="cpanel" type="usertools/cpanel"></block> <block name="topsl" type="spotlight" main-inner="1">user1,user2,user3,user4,user5</block> <block name="bt-tab" type="modules" main-inner="2">bt-tab</block> <!-- <block name="pageheading" type="heading" main-inner="2" wrap-inner="1"></block> --> </blocks> <blocks name="middle" colwidth="24" wrap-inner="1" main-inner="4"> <block name="right1">position-7</block> <block name="left1">position-5</block> </blocks> <blocks name="bottom" style="xhtml"> <block name="navhelper" type="navhelper" main-inner="1"></block> <block name="botsl" type="spotlight" main-inner="1">user6,user7,user8,user9,user10</block> <block name="footer" type="footer"></block> </blocks> </layout> I´am not sure if this could be use in the BT Travel 2.0 version and how to!? Thank you in advance!
Breno Trengrouse posted a topic in BT Slideshow ProHi, I need to add a configuration to responsive works in 1200px and 1920px screen resolutions. can you tell me how to do it? Thanks
Tiago posted a topic in BT PhotographyHi. When i visit my website in small screens (like mobile phones) the images of articles don't resize. They are cut on the right side. how can I fix this? See this page: http://www.marialunafotos.com/index.php/pt/2012-09-26-15-01-33/blog-updates It's not possible that the image of the article is responsive and resize automatically? Thanks for the help
Ross McClenahan posted a topic in BT PhotographyHi, I am using Joomla 2.5.11 with the BT Photography 1.2 template (even though the templateDetails.xml file still says 1.0). I have my Handheld, Iphone and Android Layout set to "disable" as I wish to use the responsive layout in mobile devices. When I look at the website using the Firefox responsive view things look good (img-01). However, when I look at the website on a iPhone (4s) it doesn't display well (img-02). Also, the background image is not scaling to screen size and the mobile menu drops behind the full-screen slideshow controls. Can you please take a look and let me know what I might be doing wrong? Thanks!
Pim posted a topic in BT Mobile AppsHi, Little question, i've been working on this mobile theme from you, but once i've set my own menu in stead of the demo menu, the template isn't responsive anymore. My text (in K2 and as well in the 'regular' articles) just cut off the mobile side. In the Template Manager the 'Enable Responsive' is on, and I can't see the problem here. Can you help?


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From the WHO: Case incidence continues to fall in Guinea, Liberia, and Sierra Leone. Mali has been declared free of Ebola virus disease (EVD).
Each of the intense-transmission countries has sufficient capacity to isolate and treat patients, with more than 2 treatment beds per reported confirmed, probable and suspected case. The planned numbers of beds in each country has now been reduced in accordance with falling case incidence.
Similarly, each country has sufficient capacity to bury all people known to have died from EVD.
This article from the NYT discusses the reduction of the number of cases.
Psalm 28:7
The LORD is my strength and my shield; my heart trusts in him, and I am helped. My heart leaps for joy and I will give thanks to him in song.
We thank You, Lord, for Your tender mercies in western Africa. Amen.


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The Sibling Tricycle, priced at $299.99 is an excellent product for people who are looking for something that is convenient and requires low maintenance.
With the Sibling Tricycle, parents can keep an eye on two children simultaneously, which basically means that two hard jobs are reduced to one. Families will not need to buy a new bicycle for quite some time, since this product has been constructed with excellent stability and comfort that should remain suitable for kids in the long run – even when they are going through their rapid growth spurts.
The Sibling Tricycle also comes complete with a wooden cargo box, which is situated to the rear of the rider's seat. This allows parents to store away their kiddies' toys, food and other large items, although it may not be suitable for a third child! The storage space is perfect for a day out in the countryside or a family picnic at the park.
After purchasing this product, parents should note that there is a fair amount of assembling required before they can start using the product. Anyone who has a fear of DIY tasks or little experience in constructing bikes from scratch may prefer to ask a more skilled individual to do the job for them.
While the price tag may be a little on the high side, particularly for families on a lower budget, the Sibling Tricycle could be a worthy investment for parents who would otherwise spend more on purchasing two separate bikes.


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- Firstname/Profession
- Nick
- Film & Content Producer / Videographer
- 8-12 years Experience
- Auckland, Tauranga
Represented: 16/03/18
I am a highly skilled broadcaster with over eight years' experience at British Sky Broadcasting, Ericsson in London and Sky Television in Auckland. I currently work as a freelance producer, filming, editing and researching short content.
My skills
I do all the filming for my projects using a Nikon DSLR equipt with a range of lenses to provide for professional results.
I use Adobe Premiere Pro 2018 to edit all my work and have developed my technical style to create appealing, creative and slick content.
For all graphics, I use After Effects 2018 to create titles.
Recent Employment
Media Importation Manager / Aug 2016 - Aug 2017 / TVNZ
- I coordinate with international production companies to organise the delivery of over 1000 assets a month. With an annual delivery budget of $450,000, my position requires me to think outside the box when attempting to get programmes delivered on time and under budget. This demands a high level of negotiation; organisation as well as a technical understanding of broadcast and file codecs.
- As the first point of contact for clients to TVNZ, my position entails sustaining positive relationships with all stakeholders internally and externally.
Scheduler / Feb 2016 - Aug 2016 / Warner Bros.
Editorial Assistant (Cricket) / May 2014 - Dec 2015 / Sky UK
- Identifying and managing footage for highlights packages.
- Researching possible cricket stories for broadcast.
- Accessing archival content for studio Communicating with producers during live matches, highlighting shots, commentator comments Attending field shoots Writing and submitting show treatments.
Industries I know well
Health & Beauty
Mediums I know well
Graduate Diploma, Sociology – University of Auckland 2016
Bachelor of Communications – Auckland University of Technology 2009


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What's your position/contribution to the magazine?
I was part of the Urban Legends photo shoot for the Creative Team and I did a couple little things for the layout.
What are you most excited about the new issue?
Fondue! And, of course, the magazine itself. It's always nice seeing the entire magazine and all the work people have put into each issue.
What are you planning on wearing to the BARE Launch Party?
So far, I have no idea... but I always seem to plan day-of anyway.
Check out the Facebook event for the Launch Party.
Check out more photos from the Work It, BARE series.
Subscribe | Facebook | Twitter | BlogLovin'


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The disbanding of froyotech during the ESEA Season 20 playoffs last month left team captain b4nny searching for a new team in order to compete once again at the highest echelons of competitive TF2.
Today, that search has finally come to an end, as he announced the pickup of the remnants of the Strawberry Mangoes roster (which had an interesting run in Invite last season, where they initially disbanded after being knocked out of playoff contention by Meat Market) as part of his new team.
The players picked up include corsa and Freestate as the scout pair, known for passive and aggressive play respectively, as well as Muma, who has been noted as a rising demoman star. In addition, paddie, who has played most recently on Kawaii Five-0, will be joining the team as roamer. The team is still determining who will be their medic.
The team will carry on the name of froyotech, looking to live up to the legacy the original team set during its nearly two-year reign over North America and the world.
b4nny is building another team to win it all
Team captain b4nny had the following thoughts:
I feel good about starting fresh with a group of players that are driven to practice, improve, and win. I've been down this road before where I joined with some lesser-known up-and-coming players and went on to win championships with them, so I'm hoping that I can combine my experienced leadership with their passion to play and turn it into something great once again. Like any team I join, my team is on the same page with me on our drive to win.
Scout Freestate, who was the captain for Strawberry Mangoes, shared the following with us:
We're very happy that b4nny is joining us, because he's a great player with a lot to offer, both in and out of game. He's a strong caller, which we desperately lacked last season, and he also has a ton of knowledge and understanding of the game. At the same time, we're all hungry and eager to improve, so we think that he'll be a great fit for us. We thought b4nny should take over as captain since he has so much experience and success with leading teams at the top of Invite. Right now we're working on building chemistry with this new roster, and we're aiming for the top. We realize that for now we probably won't be the powerhouse that froyotech was, but we're hoping that, with time, we'll be just as strong. We're all looking forward to an exciting season.
The roster for froyotech currently has:
- Scout: Freestate
- Scout: corsa
- Roamer: paddie
- Pocket: b4nny
- Demoman: Muma


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Nicole Khoury Biography
Nicole Khoury began her legal career before she ever entered law school, while temporarily working in the Maumee Municipal Court's Prosecutor's Office. Throughout law school, she was employed part time with Criminal Defense attorney Alan Konop performing legal research skills and eventually, sitting co-counsel with him on several high profile cases. She returned to Maumee Municipal Court in a Prosecutor internship her final semester of law school, and then immediately began working for the Lucas County Public Defender's Office in Maumee, Sylvania, and Oregon courts. Upon her passing the bar exam, she was hired on as a contracted attorney with those courts and began her private practice, both in Ohio and Michigan, primarily focusing on Criminal Defense work.
Since her swearing in ceremony in 2002, Ms. Khoury has been counsel on several high level felony and misdemeanor cases and has been certified to serve as appointed counsel on Death Penalty matters. Her constant dedication to the Lucas County Public Defender's office, primarily in Maumee and Sylvania, has given her the ability to represent thousands of indigent clients while gaining a vast knowledge and experience in trial work. Appearing in front of all judges in Lucas County, as well as several others in Ohio and Michigan, has given Ms. Khoury the unique ability to gain understanding and appreciation for different techniques and styles of the important matters that come before a judge. She has worked closely with several agencies seeking to aid her clients getting the treatment and chances they deserve to have in order to protect themselves and the community.
Outside of the courtroom, Nicole has gained statewide recognition for her contribution to our community including, and most importantly, being the founder of Project iAm and its annual fundraiser Acoustics for Autism. She developed this 501c3 organization in an effort to help local families in the Northwest Ohio area help pay for their children's treatment and therapy for Autism Spectrum disorders. Ten years later, this 100% volunteer based organization has given out over $130,000 to families in our area and is known to be one of the most loved charities in our great city. Ms. Khoury has earned the respect and accolades of her legal peers by being voted the Ohio State Bar Foundation District and Statewide award recipient for Community Service (lawyers under the age of 40) in 2012 and 2013. She has also been nominated for a Jefferson award in both 2015 and 2016 and received the "Top 20 under 40" award in 2016. in March of 2017, Nicole received the great honor of being voted the "Best Female Attorney" for 2016 by the readers of the Toledo City Paper as well as the Maumee Chamber of Commerce "Hometown Hero" (Maumee River) Award.
Nicole's dedication to her community not only includes her own foundation, but she can also be seen working as a Mentor with Mom's House (the Sister's in law Program), a board member of the Pride of Toledo Foundation, a fundraiser/promoter for Lucas County D.A.R.T. Program, a supporter and organizer for the Caly Cares Foundation, and is always the first to volunteer her time and knowledge on helping raise funding for programs and charitable causes. She has also been fortunate enough to take her love and talent for music to perform publicly in our area for almost 20 years.
Ms. Khoury received her J.D. from the University of Toledo College of Law in 2001 and her B.A., cum laude, from Hillsdale College in 1998.
On Tuesday, November 7, 2017 vote Nicole Khoury for Judge of the Toledo Municipal Court, a experienced and committed community member of our Great City of Toledo.


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Michael "Joe" Corlew
April 5, 1958 – October 30, 2018
Michael "Joe" Corlew
Michael "Joe" Corlew, son of Mary Litzler Corlew and the late Charles Corlew was born on April 5, 1958 in Dexter, Missouri and departed this life on October 30, 2018 at Barnes-Jewish Hospital in St. Louis, Missouri at the age of 60 years.
Mr. Corlew had retired from the Park Service in Wapappello. He enjoyed hunting, fishing, and his family and friends and was a resident of Essex.
Survivors include: his mother, Mary Corlew; one brother, Charles Ray Corlew of Dexter; three sisters, Sandy McMullin of Essex, Charlotte Stutts of Essex and Jan Wheeler of Essex and by many nieces and nephews.
Besides his father, he was preceded in death by one brother, Rodney "Rod" Corlew.
A graveside service will be conducted on Friday, November 2, 2018 at 2:00 PM at the Essex Cemetery in Essex for family and friends.
In lieu of flowers, memorials may be made to Christian Memorials, 701 Mo-25, Dexter, Missouri 63841.
Rainey-Mathis Funeral Home in Dexter in charge of all arrangements.


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A Guide To A Minimalist Home
The art of minimalism is a trend that popped up over recent years and continues to grow in popularity.
If the idea of minimalist living appeals to you, organising your home is the first step. Create a minimalist house by clearing away unwanted junk with these decluttering tips.
Minimalism isn't a newfound fad. It's all about consciously deciding what things are of value to you and removing everything else that's a distraction.
If you're keen to declutter your home, evaluate your belongings to decide what you need, use or brings you happiness.
A key rule to abide by: If you haven't used it in the past 12 months, it might be time to throw it out.
Many of us fall victim to keeping unwanted items out of guilt – maybe it was a birthday gift or perhaps it's still in perfect condition. Instead of throwing those things out with the garbage, pass them along to someone who'll find use for them or donate them to a charity.
Systematically declutter the house room by room. Examine the space available vs. the possessions taking up room.
Consider your attitude towards your belongings by asking yourself questions like:
- Do I own multiple versions of the same item?
- Is my closet jam-packed with clothes I never wear?
- Does it take me ages to find anything in the kitchen cupboard?
Organising your home can feel overwhelming, but if you focus on one room at a time, the process will seem much more manageable.
Online shopping makes it almost too easy to think "treat yourself!" and accidentally buy a stack of stuff you don't really need in one go.
It's tempting to see something and feel like you must own it right that very second. But next time there's a sale and your hand starts inching towards your credit card or that PayPal button, ask yourself:
- Why am I buying this?
- Do I need this right now?
- Will I still be using it in 6 months' time?
As the age-old saying goes, money doesn't buy happiness. The thrill of the purchase wears off pretty quick, so by actively stopping to think about your intentions and whether you actually need it, you're more likely to end up with items you'll continue to value.
Want to makeover every room in the house? These spring cleaning tips will help you declutter your home in no time at all.


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Understanding Your Operating System
It's really not difficult to understand the concept of your operating system. When you consider that it is an integral part of your computer that makes it easier for you to use your system, understanding an operating system can be a simple thing.
Basically, your operating system is the main program on your computer. It is installed with the intent to make operating your computer easier and more user-friendly. Operating systems were developed with you, the user in mind, and make navigating a computer as well as all the programs on it possible for almost everyone even small children.
Here are a variety of functions that your computer operating system performs:
* Determining what types of software you can install
* Coordinating the applications running on the computer at any given time
* Making sure that individual pieces of hardware, such as printers, keyboards, and disk drives, all communicate properly
* Allowing applications such as word processors, email clients, and web browsers, to perform tasks on the system (e.g., drawing windows on the screen, opening files, communicating on a network) and utilize other system resources (e.g., printers, disk drives)
* Reporting error messages
The OS also determines how you see information and perform tasks. Some operating systems utilize a graphical user interface (GUI), which presents information through pictures (icons, buttons, dialog boxes, etc.) as well as words. Other operating systems can rely solely on text.
Understanding an operating system isn't crucial to operating your computer, but it can help you when choosing which type of operating system you'll want on your computer. Most new computers come pre-loaded with Microsoft Windows, but there are a couple of other operating systems that can be installed on your computer. These include:
* Mac OS X This operating system is used primarily on Apple Macintosh computers and is similar to Windows with its GUI (although the GUI does look different) and the way it operates.
* Linux This is a UNIX based operating system that is relatively new to the mass computer market. This operating system is generally used by mainframe computers and servers, but it is growing in popularity for personal use as well.
Your operating system is the main software program on your computer made for ease of operating. While its not crucial for you to have a complete understanding of your operating system, it can help you when you are using your computer in the event anything should happen. When you have a basic understanding of your operating system, then you can take steps to correcting a problem.


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Camera Jewel House
London, Great Britain
- Architects
- Tonkin Liu
- Any
- 2001
- Preu
- Ocult
- Pisos
- Ocult
The house is a jewel box. The jewels, whose honeycombed facades light each space, are objects for living; cooking, cooling, washing and storing. As night falls, the glowing jewels transform the micro-capillary street façade into a shadow theatre of light and movement.
In the courtyard, over the water, the house faces south while the studio faces north. The two facades reflect each other, making the courtyard a space of infinite reflections. At dusk in the studio, the blind comes down and the pinhole camera projects an inverted image of the house on the back wall. Looking and being looked at become interchangeable.
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text: sky3 0 Posted January 29, 2016 I am having trouble with Defraggler just running and running. I use several maintenance programs each week, with some of them doing defragging . . . none take near as long as Defraggler. With the release of 2.20.989 I was hopeful that it would be quicker . . . unfortunately, apparently not. Recently, I ran it starting with 723 Total Fragments . . . after 4 hours it still had 536, with the remaining time showing >1 day. (I do surf the web while it is running but do not download anything else during this time.) Why does it take so long? How can I speed it up? Share this post Link to post Share on other sites


text: Welcome to phenomenarock..com! This site has informative articles on various topics like Gardening, Home Decor, and Home Improvement. This site was really built with you in mind and we hope you will find it useful. If you've anything to contribute in areas of Gardening, Home Decor, and Home Improvement feel free to fill out the contact form and reach out to us. Thank you for visiting!


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Author Affiliations
- 1 Department of Immunology and Transfusion Medicine, University Hospital of North Norway, Tromsø
- 2 Department of Immunology, University of Tromsø
- 3 Department of Immunology and Transfusion Medicine, Ullevål University Hospital, Oslo and
- 4 Faculty Division Ullevål University Hospital, University of Oslo, Norway
- Correspondence: Mette Kjær Killie, Department of Immunology and Transfusion Medicine, University Hospital of North Norway, 9038 Tromsø, Norway. E-mail: mette.kjaer.killie{at}unn.no
Background Neonatal alloimmune thrombocytopenia is most commonly due to transplacental passage of maternal anti-HPA 1a antibodies. A prospective study was carried out to evaluate the pattern and quantity of maternal anti-HPA 1a antibodies in order to predict the level of thrombocytopenia in the neonates.
Design and Methods A monoclonal antibody immobilization of platelet antigen assay was used to detect antibodies in maternal samples from 1,990 HPA 1bb women. HLA DRB3*0101 typing was performed in all immunized women by sequencing the HLA DRB3 gene when present.
Results Primary immunization more often took place in connection with delivery than during the first pregnancy. There was a strong correlation between maternal antibody levels and the platelet counts in the newborn (R2=0.49, p<0.001). A maternal antibody level above 3.0 IU/mL measured in gestational week 22 or 34 had a diagnostic sensitivity and specificity of 93% and 63%, respectively, for predicting the grade of neonatal thrombocytopenia. The women who were negative for HLA DRB3*0101 had significantly lower anti-HPA 1a antibody levels than those who were HLA DRB3*0101 positive (p<0.007). In contrast to primigravida, in whom anti-HPA 1a antibody levels increased during pregnancy, the antibody level decreased in 92 of 147 women who had been pregnant previously (P92 or more of 147 = 0.003). The anti-HPA 1a antibody level regularly increased after delivery.
Conclusions Maternal anti-HPA 1a antibody levels in weeks 22 and 34 of pregnancy are good predictors of the degree of thrombocytopenia in the newborn both in the first and subsequent pregnancies. Most mothers became immunized at the time of delivery.
Neonatal alloimmune thrombocytopenia (NAIT) in Caucasians is most commonly due to transplacental passage of maternal anti-HPA 1a antibodies (85%),1 and is a condition that resembles hemolytic disease of the newborn. Complications of NAIT, such as intracranial hemorrhage, leading to neurological disability or death, have been reported to occur in 10–30% of affected babies.2–4 At present, an accurate measurement of fetal platelet count can only be achieved through high-risk sampling of umbilical cord blood. Several prospective studies have shown a correlation between anti-HPA 1a antibody level and severity of thrombocytopenia in the newborn.4–7 A correlation was also found in two retrospective studies,8,9 whereas one other retrospective study did not find such a relationship.10 In a recent trial, we documented that identification of women with anti-HPA 1a antibodies, close clinical follow-up during pregnancy, elective Cesarean section and transfusion of compatible platelets to neonates with severe thrombocytopenia, reduce NAIT-related morbidity and mortality.11 The main purpose of this study was to describe the natural course of HPA 1a alloimmunity by recording maternal anti-HPA 1a antibody levels longitudinally throughout pregnancy and after delivery. We also studied the relationship between the platelet counts in the neonates and both the level of maternal anti-HPA 1a antibodies at delivery and the weighted mean of anti-HPA 1a antibody levels to which the neonates had been exposed during pregnancy. Finally, we tried to identify a maternal anti-HPA 1a antibody level that could be used as a predictive parameter for severe thrombocytopenia in the newborn.
Design and Methods
HPA 1a negative pregnant women (1,990 women) were tested for anti-HPA 1a antibodies approximately every fourth week during pregnancy.11 Preliminary data from the first 232 HPA 1a negative women included in this study have been published previously.5 Anti-HPA 1a antibodies were also analyzed and quantified around 6 weeks post-delivery in approximately 65% of the cases. Immediately after birth, the platelet count was determined in umbilical cord blood and/or from a capillary blood sample from the neonate. We defined severe thrombocytopenia as a platelet count <50×109/L and moderate thrombocytopenia as a platelet count between 50×109/L and 149×109/L.
This study was approved by the Regional Committee for Medical Research Ethics, North Norway (approval number: P-REK V 13/1995).
HPA 1 typing
HPA 1 phenotyping was performed either by an HPA 1a typing assay (DiaMed AG, Switzerland) in accordance with the manufacturer's instructions, or by flow cytometry, as previously described,12 using a fluoroescein isothiocyanate conjugated anti-CD61 antibody reacting specifically with the HPA 1a epitope13 (clone SZ21, Immunotech, Marseilles, France). All HPA 1a-negative samples were genotyped by a 5′ nuclease assay or melting curve analysis.14,15
Detection and quantitation of antibodies
Anti-HPA 1a antibodies were searched for using either a modification of the technique known as monoclonal antibody immobilization of platelet antigen assay (MAIPA)16–18 or the indirect platelet suspension immunofluorescence test (PIFT) analyzed by flow cytometry.19 Plasma samples from HPA 1a negative pregnant women from the northern part of Norway were screened for antibodies using MAIPA, whereas those from HPA 1a negative pregnant women from the southern part of Norway were screened for antibodies using the PIFT and, if antibodies were present, the samples were sent to the Department of Immunology and Transfusion Medicine, University Hospital of North Norway for identification of the antibodies by MAIPA. Anti-CD61, clone Y2/51 (Dako A/S, Glostrup, Denmark) was used to immobilize the glycoprotein GPIIb/IIIa complex for antibody detection.
For quantitation of anti-HPA 1a antibodies, a reference sample from one woman with a high level of anti-HPA 1a antibodies was used in two-fold dilutions from 1:2 to 1:64, to create a linear standard curve. The antibody concentration in this sample was equivalent to 15 IU/mL of the international anti-HPA 1a standard, (NIBSC product code 03/152, Hertfordshire, UK). Samples with high levels of antibodies were diluted so that the antibody concentration fell in the linear part of the standard curve. A negative sample was also run in parallel. The cut-off level for a positive test was an optical density of 0.1 at 490 nm. The weighted mean of anti-HPA 1a antibody levels during pregnancy was determined by calculating the area under the curve (AUC) describing the maternal anti-HPA 1a antibody level over time divided by the number of weeks of antibody measurements. The reproducibility of the MAIPA method was determined by calculating the critical difference from repeated intra-assay measurements of 14 samples with different amounts of anti-HPA 1a antibodies. The critical difference was found to be 30% and only changes in antibody levels exceeding this value were considered as clinically significant. An automatic microparticle enzyme linked immunoassay was used to detect Rubella antibodies (AxSYM RUBELLA IgG kit, Abbott Diagnostics Division, Abbott Park, IL, USA).
HLA DRB3 typing
HLA DRB3 typing was performed by sequencing the HLA DRB3 gene when present. The intron-located primers previously described by Kotsch et al.20 were used for the polymerase chain reaction (PCR). The PCR product was sequenced in an ABI PRISM 3730 DNA analyzer (Applied Biosystems, Foster City, USA). DNA from women whose sequencing results were difficult to interpret, and from HLA DRB3 negative women, were sent to the Tissue Typing Laboratory, Institute of Immunology, Rikshospitalet University Hospital, for HLA DRB3 typing by PCR-sequence-specific oligonucleotide probes and high resolution PCR-sequence-specific primers (GenoVision, Vienna, Austria).
One way analysis of variance (ANOVA) was used to compare mean antibody levels in women who gave birth to neonates with normal platelet counts or moderate and severe NAIT. Twin births were regarded as one birth in the statistical calculations as the platelet counts of the two pairs of twins included in this study were in the same category (normal platelet counts in one pair and severe thrombocytopenia in the other). The paired sample t-test was used to compare anti-HPA 1a antibody levels before and after delivery. The Mann-Whitney U test was used to compare the anti-HPA 1a antibody levels in HLA DRB3*0101 positive and negative women.
To examine the association between maternal anti-HPA 1a antibody level and platelet count in the neonates, we used power fit regression analysis. The platelet count (Y) is given by the formula Y=b0×xb1 where x is the anti-HPA 1a antibody level and b0 and b1 are constants.
We used a receiver operating characteristic (ROC) curve to evaluate maternal anti-HPA 1a level as a predictive parameter for severe NAIT.21 An AUC of 1.0 indicates complete discrimination, whereas an AUC of 0.5 or less means absence of discrimination. The theoretically best cut-off value was calculated using Pythagoras' theorem as described by Peat and Barton.22 The critical difference of the MAIPA indicated the minimal clinical relevant change in antibody level and was calculated according to Gluer et al.23 The probability (p) of declining antibody levels during a pregnancy in a multigravida was calculated according to the binomial distributions (two-tailed test). Our calculations were based on the assumption that p=0.5.
Maternal antibody patterns and the number of children with severe NAIT were analyzed using the χ2-test and calculation of relative risk (RR) with 95% confidence intervals (CI) when appropriate. The binomial sample distribution was calculated using an interactive calculator at the VassarStats website for statistical calculations.24 Other statistical calculations were performed with SPSS for Windows computer software (Version 11.5, SPSS Inc., Chicago, IL, USA). p values <0.05 were considered statistically significant.
The median gestational age with the 95% CI at which the first sample was taken was week 13+5 (week 12+6- week 14+4). The median (95% CI) gestational age at the time the last sample was taken was week 36+4 (week 36+0-week 36+6). The median (95% CI) gestational ages for the samples obtained around weeks 22 and 34 were 22+2 (week 21+6-week 22+5) and 34+0 (week 33+5- week 34+3), respectively.
Maternal anti-HPA 1a antibody level and platelet count in the newborn
Antibodies were detected in 170 pregnancies delivered by Cesarean section, as previously reported,11 and in three pregnancies ending in vaginal deliveries. Twenty-four of these pregnancies were included in an earlier study.5 In one of the 170 pregnancies a moderate amount of anti-HPA 1a antibodies was detected in the first sample (gestational week 34), but no anti-HPA 1a antibodies were found at the time of delivery. Due to lack of plasma for quantitative analysis in the first sample obtained, this pregnancy was excluded from our analysis. In 161 pregnancies, there was an HPA 1 incompatibility between the mother and the child.
Both maternal anti-HPA 1a antibody level at delivery and the weighted mean of anti-HPA 1a antibody levels during pregnancy were significantly higher in women who gave birth to severely thrombocytopenic children than in those who gave birth to children with moderate thrombocytopenia or a normal platelet count (Table 1). Regression analysis showed that there was a strong association between maternal anti-HPA 1a antibody level and the platelet count in the neonates (Figure 1).
Anti-HPA 1 antibody level as a predictor of severe NAIT
We then assessed the potential of maternal anti-HPA 1a antibody level for predicting severe NAIT (Figure 2). The theoretically best cut-off value for prediction of thrombocytopenia in the fetus was 3.0 IU/mL for antibody measurements close to delivery (sensitivity 81%, specificity 80%), and 5.0 IU/mL for the weighted mean of antibody levels (sensitivity 76%, specificity 81%). When using only one measurement close to delivery (week 34) and a cut-off level of 3.0 IU/mL, 10 of 55 pregnancies would have been lost from intervention in the Norwegian screening and intervention study.11 However, when two antibody measurements were performed (at weeks 22 and 34) and a cut-off level of 3.0 IU/mL was used to identify cases at risk of NAIT, the sensitivity increased to 93% but the specificity decreased to 63% (Table 2). Using this approach, the number of false negative cases (maternal anti-HPA 1a level < 3.0 IU/mL, but severe NAIT) could be reduced from 10/55 neonates to 4/55.
For 17 pregnancies (in 14 women) there was information of a previous child with severe NAIT. In seven of these 17 pregnancies, the baby had severe NAIT. An obstetric history of NAIT had a weaker positive predictive value than maternal anti-HPA 1a antibody level (Table 2).
Quantitation of anti-HPA 1a antibodies during pregnancy
Fourteen of 172 pregnancies in women with anti-HPA 1a antibodies were first pregnancies. One woman, alleged to be in her first pregnancy, was excluded because of elements of uncertainty. This woman had a high level of anti-HPA 1a antibodies in gestational week 7 but the antibodies were no longer present in week 20, suggesting immunization prior to the pregnancy. In 9 of the 13 remaining women, the antibodies were detectable in gestational week 22. The other four had detectable antibodies in gestational weeks 24, 26, 34 and 36. These 13 women had increasing anti-HPA 1a antibody levels towards term (Figure 3A). In the last sample before term the mean (±95% CI) anti-HPA 1a antibody level was 7.5 (±4.5) IU/mL whereas the weighted mean (±95% CI) of antibody level was 3.4 (±1.8) IU/mL. Six (46%) of these 13 first pregnancies culminanted with the birth of a child with severe thrombocytopenia.
In 92 of the 147 incompatible pregnancies in multi-gravida, there was a decline in antibody level during pregnancy (Figure 3B). The number of pregnancies with a decreasing antibody level was significantly higher than the number of pregnancies with no decline in antibody level (P92or more of c147=0.003). The mean (±95% CI) antibody level in the 92 pregnancies in which antibody levels declined was 15.4 (±6.1) IU/mL in the first sample obtained and decreased to 5.6 (±2.4) IU/mL at the end of pregnancy, giving a weighted mean anti-HPA 1a antibody level of 9.6 (±4.2) IU/mL. Altogether 29 (32%) children in this group were severely thrombocytopenic.
For the pregnancies in which the antibody levels dropped to below 3.0 IU/mL by the end of pregnancy, the relative risk of severe thrombocytopenia in the neonates was 0.24 (95% CI: 0.13-0.45) relative to the group in which the antibody level in last sample was >3.0 IU/mL. In 33 pregnancies, no antibodies could be detected in the last sample before delivery. None of the babies born from these pregnancies were severely thrombocytopenic although seven had moderately reduced platelet counts (67×109/L-115×109/L).
In 25 multigravida, the antibody level increased from a mean of 11.6 (±6.1) IU/mL in the first trimester to 29.5 (±16.2) IU/mL in the last sample obtained before delivery, which was equivalent to a weighted mean of anti- HPA 1a antibody levels of 16.1 (±6.1) IU/mL (Figure 3C). Twelve (48%) children in this group had severe thrombocytopenia. In 24 multigravida, the antibody level remained low, fluctuating slightly throughout the pregnancy (Figure 3D). None of the children born from these women were thrombocytopenic.
Eleven of the pregnancies in multigravida were HPA Ibb compatible. The women who carried an HPA 1a negative fetus had persistently high levels of antibodies throughout pregnancy (Figure 3E). None of the compatible children had thrombocytopenia. Figure 4 gives an overview of the different maternal anti-HPA 1a antibody patterns in the women and the outcome of their neonates.
In addition to these antibody patterns, another pattern was seen in six pregnancies in which an initially high level of anti-HPA 1a antibodies decreased by 20-30% during the course of the pregnancy. Since the decreases were less than the calculated critical difference, these six pregnancies were excluded from the large group of multigravida with decreasing antibody levels. Five of the children delivered from these six pregnancies had severe thrombocytopenia.
The relative risk of giving birth to a child with severe NAIT was zero if the anti-HPA 1a antibody level was >3.0 IU/mL in first trimester and subsequently became undetectable during gestation (multigravida, 0/15) compared to those pregnancies in which no anti-HPA 1a was detected in the first sample, but in which immunization took place during pregnancy and the anti-HPA 1a antibody level increased to >3.0 IU/mL (mainly first pregnancies, 6/10).
In all but six of the 147 pregnancies in women who had been pregnant previously, anti-HPA 1a antibodies were detected in the first sample obtained, usually in the first trimester. In the six pregnancies without detectable antibodies in the first samples, antibodies were detected in gestational weeks 14 (n=1), 20 (n=2), 22 (n=1), 24 (n=1) and 38 (n=1).
Post-partum levels of anti-HPA 1a
Anti-HPA 1a antibody levels were measured in samples taken approximately 6 weeks post-partum from 120 of the pregnancies with antibodies detectable during gestation. The post-partum antibody levels were significantly higher than those at the time of delivery in all non-compatible pregnancies (Figure 3A-D). The postpartum antibody levels in compatible pregnancies were not significantly higher than those at delivery (Figure 3E).
Post-partum samples from about 65% of the women who did not have detectable anti-HPA 1a antibodies during pregnancy were also analyzed for such antibodies after delivery. In 39 cases no anti-HPA 1a antibodies could be detected at delivery, but antibodies were present approximately 6 weeks later (Figure 3F). By adjusting for the whole study group we estimate that approximately 60 women became anti-HPA 1a positive after delivery.
Anti-HPA 1a antibody level and HLA DRB3*0101 status
Approximately 90% of the immunized women expressed HLA DRB3*0101.11 The mean (±95%CI) maternal antibody level close to delivery was 10.3 (±3.6) IU/mL in HLA DRB3*0101 positive women, compared to 0.4 (±0.3) IU/mL in HLA DRB3*0101 negative women (p=0.007). Two HLA DRB3*0101 negative women gave birth to children with moderate thrombocytopenia (platelet count: 59×109/L and 94×109/L). There were no differences in the HLA DRB3*0101 status between women immunized early in pregnancy, those immunized in the last trimester of pregnancy and those with anti-HPA 1a antibodies detected 6 weeks after delivery.
Anti-rubella antibodies
Samples from ten women were examined antibodies against rubella. In all cases anti-rubella antibodies were present and their levels stable throughout gestation, contrasting with the anti-HPA 1a antibody levels that either decreased (n= 8) or increased (n=2) in these pregnancies (data not shown).
A correlation between the level of antibodies to the HPA 1a antigen and severity of NAIT has been described by several investigators.4–9 Results from the present work, including 161 non-compatible pregnancies, further substantiate this relationship. The theoretically best antibody cut-off level for predicting an outcome appraises sensitivity and specificity equally, but is not necessarily the optimal level for use in clinical practice since the consequences of false-negative and false-positive results may be very different. Although maternal antibody levels decreased in the majority of non-compatible sub-sequent pregnancies, such that several women had low levels of anti-HPA 1a antibodies at term, some of these women still gave birth to children with severe NAIT. However, by measuring antibody levels twice, at approximately gestational weeks 22 and 34, and using a cut-off level of 3.0 IU/mL, the diagnostic sensitivity for predicting severe thrombocytopenia of the newborn was 93%. An additional advantage of measuring antibody levels early and late in pregnancy, rather than only once closer to delivery, is that appropriate clinical follow-up and possible interventions can be planned if the anti-HPA 1a level in the first sample is very high.
The weighted mean of antibody levels as a predictive parameter cannot discriminate between those women with antibody levels rising from zero to >3.0 IU/mL, and those with antibody levels decreasing to below 3.0 IU/mL. We have shown that women in the former group have a high risk of giving birth to children with severe NAIT, whereas the risk in the latter group is low. This indicates that the antibody level close to delivery may be the best predictive parameter for women who have not previously been pregnant.
Recently, Ghevaert et al.10 published the results of a retrospective study in which no correlation could be found between the maternal anti-HPA 1a antibody level and platelet count in the neonates. The explanation for the divergence between their results and ours may be differences in selection criteria. In our study, women were included prospectively after HPA 1 typing, whereas Ghevaert and his group mainly included women retrospectively on the basis of their having had a child with a bleeding tendency. They also included some women with a previous history of a child with NAIT.
It was shown in a European collaborative study on the antenatal management of feto-maternal alloimmune thrombocytopenia25 that a previous child with NAIT was the best predictor of subsequent pregnancies at risk of NAIT. Although one could argue that a previous history of thrombocytopenia may have been missed in our study, and could have biased the analyses, we found that women may have a severely affected child even if their previous child or children did not have clinical signs of NAIT. Moreover, women who gave birth to children with severe NAIT in one pregnancy did not necessarily give birth to an affected child in the next one.11 Our results indicate that the maternal anti-HPA 1a antibody level has equal predictive power as the obstetric history.
Antibody responses to the HPA 1a antigen have been reported to be restricted to women who are HLA DRB3*0101 positive.26 In our study, however, approximately 10% of the immunized women did not have this particular HLA class II antigen.11 Quantitation of the anti- HPA 1a levels revealed that these were significantly lower in HLA DRB3*0101 negative women, than in women who were HLA DRB3*0101 positive, probably reflecting that the antigen presented in the context of HLA DRB3*0101 is more immunogenic than peptides presented by other HLA class II molecules.
Altogether, anti-HPA 1a antibodies were detected in 172 pregnancies from a population of 1,990 HPA 1a negative women. Only 13 of these 172 pregnancies were first pregnancies. This is surprising, since severe NAIT has been reported to occur frequently in first born children.2 On the other hand, it was calculated that 60 women seroconverted after delivery. This may indicate that the primary immune response was established in association with, or after, the delivery, most probably due to feto-maternal bleeding. Thirteen primigravida and 6 multigravida converted from an antibody negative to antibody positive status during pregnancy. The time of conversion could not be determined for the remaining multigravida, because anti- HPA 1a was detected in the first sample collected during pregnancy. Although we cannot exclude the possibility that our MAIPA technique is not sufficiently sensitive to detect low levels of maternal anti-HPA 1a antibodies present during a first pregnancy, our observations do suggest that immunization occurs after delivery in a relatively high proportion of HPA 1a negative women giving birth to HPA 1a positive children.
Our results suggest that the immunization pattern for NAIT in many women is similar to that occuring in hemolytic disease of the newborn. It is not, therefore, unlikely that immunization against HPA 1a could be prevented in a similar way as for the RhD antigen, i.e. by administration of anti-HPA 1a antibodies after any event associated with an increased risk of feto-maternal bleeding, such as an abortion, amniocentesis or delivery. Either purified polyclonal human anti-HPA 1a immunoglobulin G or recombinant human HPA 1a antibodies could be used for this purpose.27
We and others have previously reported that anti-HPA 1a antibody levels decrease throughout pregnancy in women who have had a previous pregnancy.9,28–30 The fact that the levels of antibodies to the rubella antigen were stable during pregnancy disproves the hypothesis that the decrease in anti-HPA 1a antibody levels could be due to the normal hemodilution that occurs during pregnancy. Furthermore, women with anti-HPA 1a antibodies and an HPA 1a negative fetus did not experience decreasing anti- HPA 1a levels during pregnancy. The decrease in antibody levels in multiparous women may also have implications when evaluating possible treatment with high-dose intravenous immunoglobulin in women who have previously had a child with NAIT. The natural decline in anti-HPA 1a antibody levels in multiparous women to a low level with no clinical significance may explain why the incidence of children with NAIT is lower in these women. Indeed, when the maternal anti-HPA 1a antibody level decreased and became undetectable before delivery, there was a very low risk of thrombocytopenia in the newborn.
In conclusion, we have presented further evidence for the strong association between maternal anti-HPA 1a antibody level and platelet count in the newborn. The preterm antibody level has equal positive predictive value for NAIT as obstetric history and a much higher diagnostic sensitivity. Expression of HLA DRB3*0101 seems to be a prerequisite for producing clinically significant levels of anti-HPA 1a antibodies. In previously immunized women anti-HPA 1a antibody levels tend to decrease during pregnancy, sometimes to undetectable levels. Immunization seems to occur more often after delivery than during the first noncompatible pregnancy.
the authors would like to thank Berit Aune, Pål Øian and Lauritz B Dahl, University Hospital of North Norway; Jouko Pirhonen, Leif Svenningsen, Håkon Wergeland and Rolf Lindeman, Ullevål University Hospital; Henrik Husby, Guttorm Haugen and Morten Grønn, Rikshospitalet - Radiumhospitalet Medical Center for the follow-up of the women and/or neonates who participated in the study. We would also like to thank Helene Pedersen, University Hospital of North Norway; Geir Tomter, Elzbieta Golebiowska, Ingrid Randen and Reidun Hauge Ullevål University Hospital for technical assistance, and John Torgils Waage, Rikshospitalet - Radiumhospitalet Medical Center for resolving problems associated with HLADRB3*0101 typing in some of the women
Authorship and Disclosures
BS and AH were accountable for conception of the study; MKK collected the data and performed the experiments; MKK and JKK performed statistical analyses; the paper was written by MKK and BS, with contributions from AH and JKK. All authors designed the research, analyzed the data, critically reviewed the paper and approved the version for publication.
The authors reported no potential conflicts of interest.
- Received November 15, 2007.
- Revision received January 22, 2008.
- Accepted January 31, 2008.
- Copyright© Ferrata Storti Foundation


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This week's Music Monday is all about songs that were popular in the year 2003.
I don't know why I chose 2003, but I know there were a lot of great songs
released that year. 🙂 Let's get on with it! 😉
My Love Is Like…Wo – Mya.
Released: June 10th, 2003.
I don't even remember how or why I came across this song recently…All I know is I just can't stop listening to it! I remember first seeing this music video back and middle school, and just thinking it was awesome. She was feeling her gig! Haha! Anyway, this song has made me go on a search for other songs that are just as awesome, and also came out in 2003. I guess you can say this song is the reason for this post! 🙂 Anyway, I haven't really kept up with Mya, as the years have passed…I wonder if she is still doing music…Oh wait. Now that I think about it, I do remember that she was recently on Dancing With The Stars. I'm not really a fan of that show, but you hear things. I wonder how far she got…I should look that up! 😉
Clocks – Coldplay.
Released: December 11th, 2002 (NA).
March 24th, 2003 (EU).
As you can see, this song was originally released in 2002, in some parts of the world, but in others, it was released in 2003. And it was most popular in 2003, so I think it counts, and that is why I am including it in the 2003 list. Plus, it's my blog, and I do what I want! 😉 Anyway, this is one of my favorite Coldplay songs, and to be honest, I didn't even know that it was released back in 2003. I probably only started listening to some of Coldplay's songs, maybe…7 years ago? I just never really cared for them all that much…I mean, they do have some great songs, but I wouldn't say that I was the biggest Coldplay fan. Anyway, like I said before, this is one of my favorite songs by them, and I think it might be the first song I even listened to by them…Well, except for Yellow…But EVERYONE knows about Yellow.
That's all for this week's Music Monday.
What are some of your favorite songs from 2003?
Yeah, I know that was a long time ago, but I know you can
come up with something right? 😉
*Music Monday is a weekly meme
created by Lauren over at Always Me.


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For the second time in two weeks, a huge chunk of the internet is inaccessible due to a sudden outage. Whereas last week's outage was traced back to Verizon, this seems to be >>
For the second time in two weeks, a huge chunk of the internet is inaccessible due to a sudden outage. Whereas last week's outage was traced back to Verizon, this seems to be >>
Following the Verizon outage on Tuesday morning, the Gmail and YouTube issue on Tuesday night, and the "server configuration change" that took down Facebook and Instagram for hours on Wednesday, Apple has decided >>
Verizon Wireless was the first major carrier to launch its super fast 4G LTE network in the United States. Being the first comes with its fair share of problems, however. Earlier this week >>
We received a number of reports this morning from Verizon Wireless customers complaining that the carrier's 4G LTE network was down in various parts of the country, and Verizon has confirmed that the >>
BlackBerry users have filed a class-action lawsuit against Research In Motion after the company's massive service outage earlier this month, the Financial Post reported on Wednesday. The suit was officially filed by the >>
Police in Abu Dhabi and Dubai said the number of reported traffic accidents plunged during Research In Motion's recent three-day BlackBerry outage. According to The National, accidents fell 20% in Dubai and 40% >>
Research In Motion co-CEO Mike Lazaridis confirmed on a conference call Thursday morning that all BlackBerry services have been restored globally. The co-chief had issued a video apology to customers earlier on Thursday >>
Research In Motion co-CEO Mike Lazaridis on Thursday issued a public apology to BlackBerry subscribers around the world following a major service outage that has now entered its fourth day. "I apologize for >>


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Sorry no video available.
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About Icewolf
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July-December 5 Month Plan of Supernova X
Icewolf commented on The Zigur's blog entry in The Imperial TruthI dislike plans that have an end date and an end target. That is poor project management. This plan has no intermediate goals to measure performance against, which is a recipe for failure. What will you have done by the end of Month 1? Month 2? Month 3?
Wasn't this the name taken by the losing side in one of the Early Great Wars? (Too lazy to wiki)
Its gettin hot in hereIts the wind farms stopping the wind that are causing the global warming.
If Alliance's had truthful slogans/mottos, what would they be?
Icewolf commented on YOLO SWAG's blog entry in channel yolon blogIRON: We can't really speak latin
Some Regrets
Icewolf commented on Kzoppistan's blog entry in A Glimpse Into MadnessAs far as I understand it, some people have declared war on other people, and in response some people declared war on them, only not enough people declared war on other people for it to get fun. Or something.
Unfortunate implications and coalltion war treaty chess
Icewolf commented on Ogaden's blog entry in The Word of OgadenSell down to my level and I'll take you on. I'm just about bored enough.
Unfortunate implications and coalltion war treaty chess
Icewolf commented on Ogaden's blog entry in The Word of OgadenSo essentially we need to abandon faux legal spinning of treaties and get back t the good old values of just beating the !@#$ out of each other. Isn't that DBDC's war motto?
Practical Ethics: Casus Belli
Icewolf commented on HM Solomon I's blog entry in The Wisdom of SolomonJust because there is no justification from the war does not mean there are no reasons for it and it is divorced from political reality. There are politics in this game and lots of alliances competing to push their own agenda. It so happens that DS have managed (better than invicta) to reach a place not before reached in CN history-namely the place of having the ability to act against certain alliances without needing a justification. I find this very interesting as there are two possible actions for those that dislike this; 1. Fight back, and hope to win support for their cause on a moral ground 2. Not fight back, and hope to build a new sphere around a moral cause. Or 3. Do nothing and slowly fade from significance Options 1 or 2 both involve actual political work (so the power of persuasion and the power of ideology rather than cold gameplay and a fake justification). That sounds fun to me as we get to see a proper upfront consequence of conflicting morals.
I am fairly certain that subjectify is not a word, so.....what?
The protagonist is kind of a dick. He is crying about his love for a woman, listing only her physical attributes. Maybe if he learned to approach women as humans rather than sexual objects he might find love easier to find.
In the earlier texts it reads very much like a collection of sentences that just happen to be on the same page. This suggests you were thinking too much about each individual sentence rather than on the entire paragraph or chapter in one go, whereas this text flows much better suggesting you were less hung up on each sentence.
The writing style seems a lot better than in the other things you have posted in this blog. I suspect because you were thinking less a you wrote it rather than trying to force it out so the text is much less disjointed. Maybe that is something you could take from this and incorporate into your other writings?
No Major War Since 2013?! That's Crazy!
Icewolf commented on LOLman789789's blog entry in T.L.O.L.M.S.The first few global wars also lasted a little more than a week or two. Great War I-17 Days Great War II 5 days for the League to surrender, just over 3 weeks for LUE Great War III 5 days short of a month Unjust War 2 weeks. Modern wars take over a month for the parties to be fully engaged, let alone for anyone to start talking about endgame.
Alliance Identity
Icewolf commented on HM Solomon I's blog entry in The Wisdom of SolomonAre there any of the truly old alliances (so back to 2006 etc) that do not have any original members?


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Sort by:
Other Real-time Control MCUs
In addition to the Delfino and Piccolo MCU families, there are other MCU offerings in the C2000 family that provide real-time control functionality.
C2000™ Real-time control MCUs: Digital Control Library - Controllers
C2000 Real-Time Features
C2000™ Real-time control MCUs: Digital Control Library - Datalogging
C2000™ real-time control MCUs: Digital Control Library - Introduction
Real-time control with C2000 High-Performance MCUs
C2000™ Real-time control MCUs: Digital Control Library - Nonlinear PID Control
C2000™ real-time control MCU: Digital Control Library - Training series
The Digital Control Library (DCL) is a repository of software functions for the C2000 MCU which allows users to implement reliable, high performance control algorithms simply and efficiently. The library also contains supporting utilities such as data loggers and a reference generator.
This series will take you through:
-Introduction to the Digital Control Library
-Available classic controllers
-Data logger utilities within the DCL
-Implementation of nonlinear PID control
-Utilizing the reference generation module
C2000™ MCUs - Workshops
C2000™ MCUs - Motor Control training series
Embedded Real-Time Analysis & Diagnostics (ERAD) on C2000™ Devices
C2000™ MCUs - Overview trainings
C2000™ Piccolo™ F2805x MCUs
Functional safety on C2000 MCUs
C2000™ MCUs - EV Training Series
C2000 MCUs enable green tech
C2000™ MCUs - Digital Power training series
C2000 Developments in Digital Power Control
C2000 Digital Power Control and Implementation


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The Sir Edmund Hillary Foundation of Canada
During a trip to Nepal, Zeke O'Connor asked his friend Sir Edmund Hlllary
He replied, "You can help me by helping the Sherpas help themselves
* * * And so in 1973 began The Sir Edmund Hilary Foundation * * *
Touch the Sky
Mimi Stuart, Zeke O'Connor, close friend of Sir Edmund Hillary and founder of the Foundation, Foundation President Karen O'Connor, and Director Byron Smith with "Touch the Sky"
Four of the Sherpa people in traditional garb and welcoming scarves with artist Mimi in front of ice-carved Mt. Everest, and Arthur Boyer, grandson of Sir Edmund
Apa Sherpa (18 times to summit of Mt. Everest), Mimi, Founder Zeke O'Connor, President Karen O'Connor, Director & Gala Emcee Byron Smith, Ang Dorje Sherpa, Mingma Sherpa, and Kanchhi Sherpa
Apa Sherpa, who climbed the summit of Mt. Everest 18 times, addressing the Sir Edmund Hillary Foundation Oct. 23, 2008
Tracy Skreslet, Peter Hillary, Mimi Stuart, Byron Smith, Zachary and Jamie Smith


text:
Blogging is hard. You can lose someone in the first line you write. Or they can get halfway through and go 'By all that is holy, why I am I reading this tripe.' Or it is too long. Or conversely too short. You can ramble on and on and on and on and on and… Continue reading 20 ways to write the awesomenessest post
Month: September 2018
What are your goals for next month?
We all have to have goals. So what are yours for next month or so? So many goals. So much stuff to do. How will we get it all done? Grit and determination, my friends. Here are my goals for next month: Get out of bed every day World domination Finish editing my book… Continue reading What are your goals for next month?
Progress Report: Sorcery
I have finished the novel. And I am now entering the slow editing phase. Bit by bit it is getting there. I also wrote a blurb for myself. Not The Blurb. But a blurb: This is a book about sorcery. Sorcery that has always lived in the world. However, few of them are around due… Continue reading Progress Report: Sorcery


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One day, you'll know
He sits by the caged window, watching the shadows lengthen as his children grow
The black wheelchair rolls on the newly swept marble floor, clean as a mirror, reflecting all the dreams that died away,
He sits by the caged window, watching the shadows lengthen as his children grow,
A fragile grey hand moves with the wind, uncontrollable, making the sacred last letter impossible,
He watches the dust settle on the cold bed, the grey waves of light enter from the window, a burden, making him regret his existence.
The seed of love, planted with the youth of his hands into the ground of birth, now matured; a shadow, an image, invisible,
Blue and cuffed, the eyes, a war zone, soldiers battling against the inevitable tide ready to perish their lost souls,
The battleground now, memoriam to battling the bullets fired within oneself, the only sanity preserved by a torn, dark polaroid of his wife and the young children,
He lifts the wooden typewriter, a requiem, gifted on his father's deathbed to pass on,
Lighting his last cigarette, he cleans his typewriter with the same hands that planted the seed, held them when they cried,
The same hands that fed the ghosts, that fell short of strength when the shadows lengthened, that waved but never saw them, that now wiped the tears from the typewriter.
The rope tightens, the wooden board creaks, the chair falls and the page reads,
"One day, you'll know."
"One day."
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Some recent product updates:
- You can now log a contact (via batch update, log on a person's profile and send a 1x1 email) without specifying a path! This was originally intended to tie all communications to an engagement path - but that isn't always necessary and was causing some unintentional path logging so we have removed the requirement.
- When creating a survey the first question of the survey was always listed last as default - unless you noticed this and reordered your questions this could cause confusion when filling out the survey. This has been fixed - the first question will be listed first by default.
- Public themes had an issue where if you were accepting user submitted blog posts there was some code showing up in the submit your blog box instead of the intended text - it looked both terrible and confusing! This has been fixed!
- Speaking of themes - have you created a new theme recently? It takes around 15 minutes for themes to create - during that time you used to be able to access the theme while it was being created. This would stop the theme creation and result in broken and incomplete themes. We've removed the ability to do this and you can now only edit your theme once it has been fully created.
- In the customized export screen the voting districts selector was only showing US voting districts - this wasn't helpful to campaigns outside of the US. We've made the change where the customized export options will show the district labels available in your area.
- We removed the ability to create a list from the +More dropdown in the people section. You can already create a list from the List dropdown and it makes more sense to only be able to do it there.
- Users who had been locked out of their nation due to late payments were able to log in and charge their current credit card but not update the credit card information, so you would have to contact support to help regain access. You are now able to update your credit card and charge a new one so you can get back to work on your nation quicker!
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