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Security firm: All it took was $35 and a laptop to hack SF emergency alert system
Not long ago, skilled hackers could have blasted the sounds of Dodger Stadium or even a fake attack warning over San Francisco's emergency alert sirens, according to a security firm which exposed a vulnerability in the network.
The system, known by most residents simply for the tests that run at noon on Tuesdays, are a network of 114 sirens across the city that can be used to disseminate information in the event of an emergency. Last week, The Chronicle reported that "San Francisco officials have been quietly scrambling since early February" to fix a flaw in the system.
At the time, the city declined to elaborate on the vulnerability, but reports have revealed an encryption weakness in the radio signal to the individual sirens.
MORE: Everything you ever wanted to know about the SF alert siren
Wired reported Tuesday that an Australian-born hacker named Balint Seeber took interest in the alert system after hearing the Tuesday tests when he moved to San Francisco two years ago. As part of his work with security firm Bastille, he was able to reverse-engineer the signaling mechanism.
Seeber found that, "anyone with a laptop and a $35 radio could not only trigger those sirens, as unknown hackers did in Dallas last year. They could also make them play any audio they choose: false warnings of incoming tsunamis or missile strikes, dangerous or mass-panic-inducing instructions," Wired writes.
ATI Systems, the company that developed the network for the city, told Wired that the flaw was largely theoretical and had not been exploited in the real world. However, Bastille created a proof of concept video that allowed them to demonstrate the vulnerability without breaking the FCC regulations that would have been breached by hacking the city's system.
READ ALSO: City getting complaints about rise in scooter sharing
Lauren Jones of the San Francisco Department of Technology confirmed to SFGATE that this was the same network flaw addressed by city officials through the early part of 2018. Similar networks are in use in other parts of the country, and Jones says the department has shared what it has learned about potential vulnerabilities.
In the event of an actual emergency, the sirens blare in 15-second intervals for five minutes.


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Online But Not Alone
Our live online Data Science bootcamp takes our industry-tested curriculum and makes it available wherever you call home. State-of-the-art conferencing software allows you to chat and problem-solve with your instructors and classmates, and pair programming teaches you how to collaborate with other students. This is a live course and not self-paced. Our Online Data Science Immersive program is unable to accept students in New York.

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Andrew Bennett
Religious Freedom Institute, Cardus
This individual is not a direct affiliate of the Berkley Center. S/he previously worked with one or more of our core projects or programs. Please contact the individual at her/his home institution.
Dr. Andrew P.W. Bennett is a senior fellow at the Religious Freedom Institute and program director for Cardus Law at Cardus, Canada's faith-based think-tank, where he also serves as chair of the Cabinet of Canadians, a body of eminent Canadian lay and clerical leaders committed to reaffirming the role of religious faith within Canadian society. He is also an ordained deacon in the Ukrainian Greek-Catholic Church. Bennett was a senior research fellow with the Berkley Center's Religious Freedom Research Project during 2017 and 2018. He served as Canada's first ambassador for religious freedom and head of the Office of Religious Freedom in the Department of Foreign Affairs from 2013 to 2016, during which time he led in defending and championing religious freedom internationally as a core element of Canada's principled foreign policy. At the same time, he served as Canada's head of delegation to the International Holocaust Remembrance Alliance, a 31-country body that leads international efforts in Holocaust education, research, and remembrance. Bennett holds a B.A. (Hons.) in history from Dalhousie University, an M.A. in history from McGill University, and a Ph.D. in politics from the University of Edinburgh.


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I have finally found a few free minutes to sit down behind my computer and put together a fishing report for everyone. It has fortunately been an extremely busy October, and I've only had a couple of days off since the beginning of the month. Our weather has been all over the place, f
I first must apologize for my extended absence from my fishing report. I have been fortunate to have been busy fishing, plus adding in a few boat and house projects, and I've found myself spread fairly thin. We still have plenty of muggy, summertime heat hanging around, but it looks l


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Core Faculty
Senior Staff
Jessica Alfoldi, Manager, Scientific Data & Partnerships
Jessica is the associate director of genomic data; she coordinates our work on gnomAD and other related projects, as well as our interactions with industry.
Alex Bloemendal, Computational Scientist II
Alex Bloemendal is a computational scientist at the Broad Institute of MIT and Harvard and at the Analytic and Translational Genetics Unit of Massachusetts General Hospital. As a member of Broad institute member Ben Neale's lab, Bloemendal leads a group in developing new methods to analyze genetic data, harnessing its unprecedented scope and scale to discover the genetic causes of disease. He also co-founded and directs the Models, Inference & Algorithms initiative at the Broad, bridging computational biology, mathematical theory, and machine learning. Bloemendal is an institute scientist at the Broad. Bloemendal was previously a research scientist in the Program for Evolutionary Dynamics and a Simons Fellow in the Department of Mathematics at Harvard University. His research in probability theory and random matrices focused on questions of signal and noise in high-dimensional data; he proved an open conjecture with wide-reaching applications for fields including population genetics. He also earned a teaching award for an advanced course on probability. Bloemendal received an Hon. B.Sc., M.Sc., and Ph.D. in mathematics from the University of Toronto.
Jon Bloom, Principal Software Engineer
Jon Bloom is a mathematician, engineer, and co-founder of the Hail project (hail.is) at the Broad Institute, building an open-source framework for scalable genomic analysis. He also co-founded and directs the Models, Inference & Algorithms Initiative (broadinstitute.org/mia), bridging computational biology, mathematical theory and machine learning. Prior to joining the Broad, he did research in geometry and algebraic topology as a Moore Instructor and NSF Postdoctoral Fellow in Mathematics at the Massachusetts Institute of Technology. While there, he re-architected the department's course 18.05 on probability and statistics for life scientists, now among the most popular offerings on MIT OpenCourseWare. He received his B.A. from Harvard University and Ph.D. from Columbia University in Mathematics.
Claire Churchhouse, Scientific Advisor
Claire completed a doctorate in the department of Statistics at Oxford University, under the supervision of Jonathan Marchini, where her thesis work focused on statistical methods of ancestry deconvolution in admixed populations. She joined to the Broad Institute in 2012 as a postdoc in David Altshuler's group where she developed QC methods for untargeted metabolomics data, and studied associations between the metabolome, genetics, and type 2 diabetes risk. In early 2015 Claire joined the Neale group as Scientific Advisor, responsible for helping to drive and implement the scientific strategy of the group and for supporting group members across a diverse range of projects.
Dan Howrigan, Research Scientist and Data Group Leader
Daniel oversees the SNP array and sequence analysis pipeline in the Neale lab, with a primary focus on furthering genetic discovery in complex psychiatric disease through collaborative partnerships and high-throughput data analysis. His post-doctoral research has been focused on deciphering the role of rare genetic variation in schizophrenia. Daniel received his PhD in 2012 from the University of Colorado, Boulder (supervised by Dr. Matthew Keller and Dr. Matthew McQueen). During his time in Colorado, his research investigated the detection of autozygosity (a genetic signature of inbreeding), and its role in general cognitive ability and schizophrenia liability.
Hailiang Huang, Instructor
Hailiang Huang is an Instructor in the Analytic and Translational Genetics Unit at Massachusetts General Hospital and an Associated Scientist of the Broad Institute of MIT and Harvard. He is also an instructor in the Department of Medicine at Harvard Medical School. Hailiang's research focuses on the genetics of complex disorders, especially autoimmune and psychiatric disorders. He is interested in developing new statistical and analytical methods, and use them to pinpoint and understand the genetic factors driving human complex disorders. His studies usually use large-scale omics data from various consortia and public available sources such as UK Biobank, NIH Roadmap, and GTEx. Hailiang developed GWiS, a gene-based association test that has been used in many consortia to find genes associated with human complex disorders (Huang et al., PLoS Genetics, 2011). He is a member of the International Inflammatory Bowel Diseases Genetics Consortium (IIBDGC) and has co-led its recent fine-mapping effort to resolve known genetic associations to variants with high causal probabilities (Huang et al., Nature, 2017). He is also leading a workgroup in the Psychiatric Genomics Consortium (PGC) to build a large-scale Asian schizophrenia cohort and use this cohort to understand the genetic architecture of schizophrenia in the Asian populations. Hailiang's other research interests include developing methods for testing rare variants with population stratification, investigating the connection between tissue-specific gene regulation and non-coding genetic associations, and understanding the genetic mechanisms underlying the spontaneous clearance of the hepatitis C virus. Hailiang received cross-disciplinary training combining engineering, genetics and medicine. He earned his Ph.D. from the Department of Biomedical Engineering at the Johns Hopkins School of Medicine, supervised by Dr. Joel Bader. He completed his postdoctoral training with Dr. Mark Daly at MGH and the Broad Institute.
Monkol Lek, Sr. Researcher
Monkol is a computational biologist focusing on the large-scale analysis of exome sequencing data, and its application to improving understanding of human biology and disease risk. He leads analysis and methods development for our Center for Mendelian Genomics. @theFourier2k
Jamie Marshall, Research Scientist II
Jamie is a research scientist leading the group's wetlab efforts. She is particularly interested in the characterization of genes and variants implicated in muscle disease.
Anne O'Donnell, Research Fellow
Anne is the Associate Director for the Center for Mendelian Genomics at the Broad Institute of MIT and Harvard and a member of the Analytic and Translational Genetics Unit at Massachusetts General Hospital. She is an Instructor in the Department of Pediatrics at Harvard Medical School. Anne's research in the MacArthur lab focuses on improving rare variant interpretation and novel disease gene discovery using large scale reference population databases including ExAC and gnomAD. She has contributed to the development of the frequency filtering approach and also constraint metrics including pLI and regional missense constraint. She is also interested in understanding the molecular mechanisms of incomplete penetrance. In her second life, she is a clinical and biochemical geneticist at Boston Children's Hospital where she runs a clinic focused on evaluating families with epigenetic disorders. Anne received her MD, PhD from Columbia Medical School where she studied with Drs. Timothy Bestor and Fatemeh Victoria Haghighi on the role of DNA methylation changes in the pathophysiology of cancer and psychiatric disease. She completed her clinical training at Boston Children's Hospital and Harvard Medical School in a combined pediatrics-genetics residency and a medical biochemical fellowship. As a clinical fellow, she joined the MacArthur laboratory.
Stephan Ripke, Research Scientist
Stephan is a key member of the Psychiatric Genomics Consortium (PGC), a collaborative effort that involves 50 datasets from research groups from 17 countries. Stephan is responsible for performing the combined analysis of the raw genetic data from the Consortium members. To do this, he has created a computer pipeline that standardizes data, imputes missing values, performs the final analysis and brings the results into displayable format (e.g. the Web based toolRICOPILI). This collection of computer programs is unique in its ability to analyze millions and millions of data points in a short period of time, a critical ability that has allowed genome-wide association studies of psychiatric data to produce concrete results. Stephan's current GWAS research focuses on schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, attention deficit hyperactivity disorder, and cross-disease analyses. In addition to this research project, Stephan is collaborating with a plethora of additional GWAS groups (mostly consortias) for human traits, like HIV, Crohn's Disease, AMD (age-related macular degeneration),Psychopharmacogenetics, smoking, height, weight, sudden cardiac death, stroke,anxiety,multiple sclerosis, and restless legs syndrome.
Cotton Seed, Senior Principal Software Engineer
Cotton Seed is a Senior Principal Software Engineer and leader of the Hail team at the Broad Institute of MIT and Harvard. Prior to joining the Broad, he did a PhD in Mathematics at Princeton University and spent over a decade building high-performance computing systems with a focus on advanced compiler technology at Connected Components Corp, Intel, and Reservoir Labs, among others.
Christine Stevens, Sr. Project Manager
Christine Stevens, a Senior Project Manager, joined The Broad Institute in 2003. Christine possesses a diverse knowledge of genomic technologies, and analyzes, and has strong experience in funding regulations and compliance. She is well versed in project management, high-throughput processes, and large-scale data. Christine oversees the Autism and Inflammatory Bowel Disease genetics projects.
Ben Weisburd, Principal Software Engineer
Ben is a principal software engineer working on developing methods for interpreting DNA sequencing data in the context of severe Mendelian diseases. He is the lead developer for our seqr rare disease analysis platform. @benweisburd
Alice Zheng, M.S., Senior Project Coordinator
Alice Zheng is a Senior Project Coordinator in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard. She supports Hailiang Huang with the Asian Initiatives and works in conjunction with cross-functional groups in America and Asia to support the project management team and their ongoing research of psychiatric diseases. Her role involves collaborative research projects with several of Broad's international partnerships as they continue to work towards cutting-edge research in the area of severe mental illnesses.
Alicia Byrne, Visiting PhD Student
Alicia is a graduate student from the University of South Australia. She is working on the molecular diagnosis of rare genetic disease, with particular focus on disorders contributing to perinatal mortality.
Marco Chiumiento, Visiting Graduate Student
Henrike Heyne, Visiting Research Fellow
Henrike Heyne is a research fellow at ATGU and the Broad Institute of MIT and Harvard, mentored by Prof. Mark Daly. She is generally interested in human genetics; with a focus on rare epilepsy disorders and aiming to bring research back to clinical application. Previously based at the University of Leipzig and the Max-Planck-Institute for Evolutionary Anthropology, she has also been working on the genetics of other brain phenotypes like obesity and animal behavior.
Hyo-Won Kim, Visiting Researcher
Hyo-Won is a visiting researcher from University of Ulsan, Asan Medical Center. She completed her PhD in Medical Science at Seoul National University, Korea. She has been studied the genetics of neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder. She is interested in predicting the risks and treatment outcomes for neurodevelopmental disorders.
Ruize Liu, Visiting Scholar
Clara Williamson, Visiting Undergraduate Student
Science Operations
Liam Abbott, Associate Computational Biologist I
Liam is an Associate Computational Biologist in the Neale lab. He is interested in understanding the genetics underlying human traits and disease through the application of statistical methods and computational techniques. He received an MS in Applied Statistics from the University of Michigan in 2015 and a BA in Mathematics from Williams College in 2013.
Harindra Arachchi, Software Engineer
Harindra is part of the Engineering team at the Broad Center for Mendelian Genomics at ATGU. Prior to that, he worked at the Pasteur Institute in Paris and was with the Cancer group at the Broad Institute of MIT. He works on developing software tools and methods that help study rare genetic diseases. He has a Bachelors degree in Computer science with minors in Biology and Mathematics along with a MBA with a concentration in Strategy and Business analysis.
Brandon Avila, Associate Computational Biologist
Brandon Avila is an Associate Computational Biologist at ATGU and the Broad Institute of MIT and Harvard in Dr. Mark Daly's lab. His current research involves rare variant discovery in Inflammatory Bowel Disease. He is a recent graduate of MIT, where he received is undergraduate degree in Mathematics and Physics.
Samantha Baxter, Genetic Counselor/Clinical Project Manager II
Samantha is the clinical project manager at the Broad Institute's Center for Mendelian Genomics. She is a genetic counselor who has worked in the area of cardiovascular genetics and now focuses on the management and sharing of both clinical and genetic data.
Sam Bryant, Senior Data Management Specialist
Jaime Chang, Project Coordinator
Jaime Chang is a Project Coordinator for the Rare Genomes Project and Broad Institute's Center for Mendelian Genomics. She was previously a research associate in the Broad Institute's Genetic Perturbation Platform and also has prior marketing experience in healthcare and biotech.
Katherine Chao, Associate Computational Biologist I
Katherine is a computational biologist conducting exome analyses for families with rare disease. Before joining the Broad, she worked in the NIH's Undiagnosed Diseases Program.
Christina Chen, Computational Associate I
Christina is an Associate Computational Biologist in the Neale Lab. She graduated in 2017 from Harvard College with a BA in Mathematics. She is interested in applying mathematics to solve problems in biological contexts. She is currently working under the mentorship of Alex Bloemendal to extend the LD regression model to account for epistasis and determine if this extension can capture additional heritability.
Danfeng Chen, Computational Associate I
Danfeng is an Associate Computational Biologist with Dr. Benjamin Neale at the Analytical Translational Genetics Unit and the Broad Institute of MIT and Harvard. Her research focuses ondeciphering the genetic risk factors of psychiatric diseases, and developing analytical tools for GWAS data. Danfeng is a recent graduate from Harvard T. H. Chan school of Public Health where she received her master degree in Computational Biology & Quantitative Genetics.
Laura Gauthier, Computational Scientist II
Laura is a computational biologist jointly based in the MacArthur lab and the Broad Institute Data Sciences and Data Engineering (DSDE) platform. She works on the development of variant-calling pipelines for rare disease samples.
Mekdes Getaneh (Duni), Senior Coordinator
My name is Mekdes, but I go by Duni. I am originally from Ethiopia. I am currently working in the MacArthur lab more specifically in Rare Genomes Project as a Senior coordinator. I graduated from Gordon College with a B.S. in Biology in 2014.
Jackie Goldstein, Associate Software Engineer
Jackie Goldstein is an Associate Software Engineer and is a member of the Hail team. Her previous work included developing a rare variant caller for genotyping arrays and finding genetic risk factors for adverse drug events such as clozapine-induced agranulocytosis and drug-induced liver injury. She also contributed to the design of the PsychChip array and the subsequent genome-wide association studies for the Psychiatric Genomics Consortium.
Sreeja Kalapurakkel, Research Associate I
Daniel King, Senior Software Engineer
Dan is a software engineer working on the Hail project. He is interested in developing libraries and languages that provide a natural and high-performance mode of interaction for scientists. He has previously worked at a local software start-up and studied for a (incomplete) PhD in Programming Languages.
Mitja Kurki, Research Fellow
Mita is a software engineer transformed into bioinformatician with general research interests in application of genomic and computational methods to elucidate the genetic basis of complex diseases. His current projects focus on intellectual disability, Alzheimer's disease, familial migraine and intracranial aneurysms. A long-term goal of his research is in development of Finnish genetic reference database (http://www.sisuproject.fi/) and nation- and phenomewide genetic analyses utilizing extensive Finnish health care registries. He is leading the genetic analysis team in a large project, which aims to genotype 500 000 Finns and couple the genetic data with health registry data of each participant. These activities will contribute to a reference database used in rare variant studies, powerful phenome-wide association studies elucidating genetic basis of health and disease and eventually hopefully as a step in realizing the promise of personalized medicine in the future. He has previously worked as a software engineer in startup environment, researcher in laboratory of functional genomics and bioinformatics, University of Eastern Finland and as a bioinformatician in NeuroCenter,Kuopio University Hospital, Finland. "
Kristen Laricchia, Associate Computational Biologist I
Kristen is an associate computational biologist who works on the preliminary analyses and management of datasets for the Exome Aggregation Consortium and novel gene discovery for Mendelian diseases.
Idara Ndon, Project Coordinator
Melanie O'Leary, Senior Clinical Manager
Melanie is a genetic counselor and the senior clinical manager for the Rare Genomes Project. Her background spans clinical care, research coordination, and clinical laboratory settings. She is involved in multiple aspects of the project including leading the return of results to families enrolled in the study.
Tim Poterba, Software Engineer
Tim Poterba is a software engineer working on the Hail project in Ben Neale's group at the Broad Institute and Massachusetts General Hospital. His primary interest is the application of modern computing technology to accelerate biomedical research. Prior to joining the Broad, he studied protein folding dynamics at the Max Planck Institute for Biochemistry on a Fulbright Scholarship. He received his B.A. in Biochemistry and Biophysics from Amherst College in 2013.
F. Kyle Satterstrom, Computational Biologist
Kyle Satterstrom is a computational biologist in the Daly group at ATGU and the Broad Institute of MIT and Harvard. His work focuses on aggregating and analyzing whole exome sequence data to study the genetic risk factors associated with autism spectrum disorder. Prior to joining ATGU, Kyle received his PhD in bioengineering from Harvard in 2015. He conducted his dissertation research in the laboratory of Marcia Haigis at Harvard Medical School, where he studied genes involved in the regulation of metabolism and longevity.
Patrick Schultz, Software Engineer
Patrick Schultz recently joined the Hail team as a software engineer. Patrick is especially interested in the intersection of math and computer science and recently posted a NASA-funded book on his postdoctoral research in mathematics at MIT (https://arxiv.org/abs/1710.10258). He is excited to bring theory to practice for scientists by helping to build a better Hail.
Alex Smith
Matthew Solomonson, Associate Computational Biologist I
Matt is a software engineer interested in developing interactive visualization tools for exploring large biological datasets. He studied protein structural biology during his PhD at the University of British Columbia.
Katherine Tashman, Associate Computational Biologist I
Kate Tashman is an Associate Computational Biologist with the Neale Lab. She is interested in studying the genetic effects on psychiatric illness as well as neurodevelopmental disorders. She received her B.S. in Mathematical Sciences from Binghamton University in 2017.
Jacob Taylor
Grace Tiao, Associate Computational Biologist I
Grace is a computational biologist working on computational methods development and analysis of the Genome Aggregation Database (gnomAD). She studied statistics and mathematics at the University of Oxford and worked for several years in the Cancer Genome Analysis group at the Broad.
Amanda Wang, Associate Software Engineer
Emilie Wigdor
Emilie is an associate computational biologist with Dr. Elise Robinson. She graduated with a BA in cognitive neuroscience and evolutionary psychology from Harvard University in 2015. Her research focuses on genetic risk factors for neuropsychiatric and neurodevelopmental disorders. Emilie is also a Research Assistant for Dr. Karestan Koenen, working on the Stanley Global Neuropsychiatric Genomics Initiative at the Broad.
Michael Wilson, Associate Computational Biologist I
Mike is an associate computational biologist working on the preliminary analyses of exomes and genomes to identify causal candidate genes and variants. He also manages datasets from Mendelian disease collaborators. He was previously a Senior Research Associate in the Broad Institute's Clinical Research Sequencing Platform.
Tetyana Zayats, Researcher
Tetyana is a visiting researcher from the University of Bergen. She is interested in the genetics of complex disorders. In particular, she focuses on the phenomena beyond common variant association, such as the role of rare variants, environment, epistasis, physiological and psychological body changes as well as parent of origin effects. The main phenotype of her work is attention deficit hyperactivity disorder (ADHD), in the research of which she has been involved for the past 3 years. Previously, she has worked on a variety of complex disorders, such as myopia, physical activity, bone density, finger length ratio and ankylosing spondylitis.
Affiliated Faculty
Research Fellows
Mykyta Artomov, Research Fellow
Mykyta is a research fellow in Mark Daly's group. His research is devoted to developing computational methods for gene networks analysis and their application to association studies specifically focused on cancer genetics. He is searching for ways of applying new methods to understand genetic factors influencing immune response (and differential survival) to cancer disorders.
Elizabeth Atkinson, Research Fellow
Elizabeth is a postdoctoral research fellow in ATGU and the Broad Institute of Harvard and MIT, advised by Dr. Mark Daly and working closely with Dr. Benjamin Neale. She did her PhD work at the medical school of Washington University in St. Louis under Dr. Jim Cheverud, examining the genetic architecture and evolvability of brain traits in a pedigreed baboon population. She then received an NIH IRACDA fellowship to work with Dr. Brenna Henn at Stony Brook University, where she characterized patterns of genetic diversity in Southern Africa and investigated the molecular evolution of canonical brain genes across diverse human populations. At ATGU, she is broadly working on applying and improving methods for studying the genetic basis of neuro-psychiatric diseases in underrepresented human populations.
Andrea Byrnes, Research Fellow
Andrea is a postdoctoral fellow with Benjamin Neale's group. Her current research focuses on using data from current-era RNAsequencing experiments to better capture transcriptional activity and diversity in the human brain. The ultimate goal of these activities is to better understand the etiology of psychiatric illnesses such as schizophrenia, bipolar disorder, major depression and autism. The current projects focus on the handling of RNA-seq data in normalization, isoform assembly, differential expression and enrichment. Andrea also works with the GTEx Consortium and the Stanley Center for Psychiatric Research.
Caitlin Carey
Caitlin Carey is a Postdoctoral Associate at the Broad Institute of Harvard and MIT, where she is advised by Dr. Elise Robinson. Prior to joining the Broad, she earned her PhD in Psychological and Brain Sciences from Washington University in St. Louis under the direction of Dr. Ryan Bogdan, where her dissertation focused on links between polygenic risk, neural function, and behavior in externalizing psychopathology. She is interested in cross-disorder comorbidity and within-disorder heterogeneity in neuropsychiatric disorders and is currently working to characterize the contributions of rare and common genetic variation to specific phenotypes in autism spectrum disorders.
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Chia-Yen Chen, Research Fellow
Chia-Yen Chen, Sc.D. is a postdoctoral research fellow in both the Analytic and Translational Genetics Unit (ATGU) and the Psychiatric and Neurodevelopmental Genetics Unit (PNGU) at Massachusetts General Hospital. He is also affiliated with the Broad institute of MIT and Harvard. Mentored by Jordan Smoller, M.D., Sc.D. and Benjamin Neale, Ph.D., Dr. Chen's research interest lies in understanding the genetic basis of psychiatric disorders, especially posttraumatic stress disorder (PTSD) and other stress-related disorders, through developing novel statistical genetics methods and analyzing large-scale genomic data. Dr. Chen developed novel methods for Mendelian randomization, polygenic risk prediction models, and ancestry inference. He is also the lead analyst for the genomic analyses in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS), a member of Psychiatric Genomics Consortium (PGC) PTSD working group and SCZ working group, and a member of International Cohort Collection for Bipolar Disorder. Dr. Chen earned a BSc in Life Science in 2004 and a MSc in Epidemiology in 2006 from National Taiwan University. He earned a Sc.M. in Biostatistics in 2012 and a Sc.D. in Epidemiology in 2013 from the Harvard School of Public Health. His doctoral advisor was Alkes L. Price, Ph.D.
Sali Farhan, Research Fellow
Sali Farhan is a Postdoctoral Fellow with Dr. Benjamin Neale and Dr. Mark Daly. She completed her PhD in Biochemistry and Genetics at Robarts Research Institute at Western University in Canada. Her PhD research focused on identifying the genetic basis of Mendelian diseases and complex neurodegenerative diseases primarily amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Currently, she is analyzing whole exome and genome sequencing data from a large cohort of sporadic and familial ALS cases to elucidate the genetic determinants of neurodegeneration.
Yen-Chen (Anne) Feng, Research Fellow
Anne is a recent graduate from the program of statistical genetics and genetic epidemiology at Harvard School of Public Health and now a postdoctoral fellow working with Dr. Ben Neale at ATGU and Dr. Jordan Smoller from PNGU. Her doctoral research focused on developing and applying statistical methods to a range of human -omics data, including GWAS, epigenomics, and metabolomics data. She's interested in exploring the genetic underpinnings of and across neuropsychiatric traits and will be working on a project to identify genetic variation affecting the risk of common epilepsies using sequencing data.
Laurent Francioli, Research Fellow
Laurent is a postdoctoral fellow interested in developing novel computational approaches for large-scale genomics. He is working on statistical methods for novel gene discovery in Mendelian diseases, and leading the Genome Aggregation Database (gnomAD).
Andrea Ganna, Research Fellow
Andrea Ganna is a research fellow in Ben Neale's group at the Analytical and Translational Genetic Unit at Massachusetts General Hospital and Harvard Medical School and he is affiliated with the Broad Institute. He obtained his bachelor and master degree in statistics at the University of Milano Bicocca, Italy and completed his PhD studies in medical sciences at Karolinska Institutet, Sweden. During his PhD studies, he was leading analyst for several large-scale genomics consortia under the supervision of Prof Erik Ingelsson. He worked on developing novel methodologies to integrate metabolomics, genetic and phenotypic data for prediction of cardiovascular diseases and short-term mortality. He is currently working on exploring the impact of ultra-rare deleterious variants across the phenotypic spectrum with particular focus on neurodevelopment and psychiatric disorders, as well as cognitive and educational outcomes in the general population.
Julia Goodrich, Research Fellow
Julia is a postdoctoral fellow in Daniel MacArthur's group. She completed her Ph.D. in Genetics in 2016 at Cornell University, examining the role of host genetics in shaping gut microbiome composition. For her postdoctoral work, she is broadly interested in developing methods to improve the diagnosis of rare genetic diseases. Currently, she is focused on detecting structural variants in rare disease cohorts.
Padhraig Gormley, Research Fellow
Padhraig is a Postdoctoral Fellow at MGH and the Broad Institute of MIT and Harvard, advised by Prof. Aarno Palotie. His research interest is in human genetics and understanding the genetic basis of complex diseases. In particular, identifying genes that influence risk for neurological disorders, including migraine, epilepsy, and stroke. The work involves international collaborations via membership of the International Headache Genetics Consortium and the EuroEPINOMICS Consortium. He has worked previously as a Postdoctoral Fellow in human genetics at the Wellcome Trust Sanger Institute (UK) and received his PhD in Computational Biology from Queen's University Belfast (N. Ireland) in 2010.
Konrad Karczewski, Research Fellow
Konrad is a postdoctoral scientist researching the prevalence and impact of loss-of-function variation in healthy human genomes and developing software pipelines for the improved annotation thereof.
Robert Maier, Research Fellow
Robert is a postdoctoral fellow in Ben Neale's lab. He completed his PhD in quantitative genetics at the University of Queensland in 2017, where he worked on the development and application of genetic risk prediction methods. His current focus is on using genetic data to better characterize correlated phenotypes.
Jessica Marden, Research Fellow
Alicia Martin, Research Fellow
Alicia is a research fellow in ATGU and the Broad Institute of MIT and Harvard, advised by Dr. Mark Daly. Her general interests are in human population genetics, especially in leveraging demographic history to aid in disease studies. Her current projects utilize pairwise identity-by-descent (IBD) sharing to assess recent population history, associate haplotypes with psychiatric disorders, and infer the ages of disease risk haplotypes and alleles to better understand their evolutionary pressures. She obtained her PhD degree in 2015 from the Genetics Department at Stanford University (advised by Dr. Carlos D. Bustamante) for her work in genetic and regulatory variation across diverse human populations. You can find additional information on Alicia's research <ahref="http://aliciarmartin.com/">here</a>.</p>
Duncan Palmer, Research Fellow
Duncan is a postdoctoral fellow in the Neale Lab. After working viral evolution – he studied the interaction between HIV and the CTL immune response – he switched countries and genome lengths, and began working on human genetics in the spring of 2016. He is currently working on methods to estimate genetic contributions to heritability of complex traits by both extending existing methodology and developing new methods. He's broadly interested in population genetics and selection, and the increased power gained by accounting for population stratification and learning about fundamental biological processes when performing inference.
Rebecca Shafee
Tarjinder Singh, Research Fellow
TJ is a postdoctoral fellow in Dr. Mark Daly's group. He completed his Ph.D. in 2016 at the Wellcome Trust Sanger Institute, where he studied the role of rare variation in the genetic architecture of psychiatric and neurodevelopmental disorders. Mentored by Dr. Daly and in close collaboration with Dr. Benjamin Neale's group, he currently works on the meta-analyses of sequencing data in psychiatric traits, with a primary focus on the genetics of schizophrenia.
Patrick Turley, Research Fellow
Patrick is a post-doctoral fellow at ATGU and the Broad Institute of Harvard and MIT. He is advised by Dr. Benjamin Neale, researching statistical methods applied to topics in the intersection of economics and genetics. He is also a core researcher of the Social Science Genetic Association Consortium and an affiliated postdoc with the Behavioral and Health Genomics Center at University of Southern California. Currently, his work focuses on analyzing genetic data to explore the relationship between traits and boost power for association.
Kumar Veerapen, Research Fellow
Kumar is a research fellow advised by Aarno Palotie, M.D., Ph.D., at the Psychiatric & Neurodevelopmental Genetics Unit (PNGU) and Analytic and Translational Genetics Unit (ATGU) at Massachusetts General Hospital, the Broad Institute of MIT and Harvard, and Harvard Medical School. His general research interests are in human genetic epidemiology, particularly in modeling and understanding complex genetic diseases. Currently, he is working on understanding familial polygenic risk of migraines in Finns. He obtained his Bachelor's degree (First Class Honours) in Biotechnology at UCSI University, Malaysia (advised by Renee Lim Lay Hong, Ph.D.) and completed his Ph.D. in Biomedical Sciences in 2016 at the University of Miami (advised by Olaf Bodamer, MD, PhD). During his undergraduate and subsequent faculty position at UCSIUniversity, his research interests included heterologous expression of recombinant proteins and candidate gene studies of myopia and obesity in Malaysian adolescents. For his Ph.D., his work focused on the genetics of preterm birth which included whole exome sequencing analysis of a Miami-Latino population, and an integrated analysis (RNA-seq and methylation) of a longitudinally ascertained birth cohort.
Raymond Walters, Research Fellow
Raymond is a post-doctoral research fellow in Dr. Bejamin Neale's lab at ATGU and the Broad Insitute of MIT and Harvard. His research focuses on the development and application of statistical best practices for studying the genetics of psychological traits and disorders. Prior to joining the ATGU, Raymond earned his Ph.D. in Psychology in 2014 from the University of Notre Dame under the direction of Dr. Gitta Lubke. His current work includes development of a pipeline for rapid analysis of genome-wide SNP arrays in family-based data in the Psychiatric Genomics Consortium (PGC) and assessment of novel methods for quantifying the architecture of SNP effects across the genome.
Zachary Zappala, Research Fellow
Zach is a postdoctoral fellow interested in developing novel methods to measure variant penetrance and understanding the underlying factors that affect variant pathogenicity. @zaczap
Jill Doucette, Research Administrator
Jill provides administrative support to Mark Daly, the Chief of ATGU and his lab in their administrative and research efforts as part of a growing administrative team spanning two institutions, MGH and the Broad Institute. Jill has been working in ATGU since 2010.
Carla Hammond, Staff Assistant II
Carla provides administrative support to Benjamin Neale as well as the Neale Lab in their administrative and research efforts as part of a growing administrative team spanning 2 institutions, MGH and the Broad Institute. Carla has been working in ATGU since August of 2013.
Elizabeth Raynard, Administrative and Grant Manager
Beth manages the administrative and grant activities of the Unit that span the Massachusetts General Hospital and Broad Institute. She works with various departments at both institutions for Appointments and on boarding, International Offices for visa processing, Institutional Billing Agreement execution, Grant preperation etc. She has been working at MGH since 2007.
Sumaiya Iqbal, Research Fellow
Dennis Lal, Research Scientist
I am a "Research Scientist" at the Stanley Center (and Group Leader at the Cologne Center for Genomics). "Why did the patient develop this disease?" "Will the patient respond to this medication?" "Can we predict the disease prognosis?" "What is the underlying mechanism?" My long-term research interests involve the development of a comprehensive understanding of how alterations in the genome contribute to brain disorders. My academic training and research experiences have provided me with an excellent background in multiple disciplines including molecular biology, genetics, and bioinformatics as well as a comprehensive understanding of the clinical and neurological presentation of neuropediatric disorders. Overall, the main focus of the group that I lead is the discovery, evaluation, and translation of genetic variants into clinical care. Specifically, we aim to develop computational methods which integrate large genetic, clinical, and biological data sets to improve the prediction of genetic variant effects on patient outcomes – paving the way for personalized medicine.
Eric Minikel, Graduate Student
Eric is a computational scientist interested in using large-scale exome sequencing data to inform diagnosis and therapeutic development strategy in Mendelian disease, particularly neurodegenerative disorders. He now works part-time while completing his graduate degree in the Biomedical and Biological Sciences Program at Harvard.
Graduate Students
Beryl Cummings, Graduate Student
Beryl is a graduate student from the Biomedical and Biological Sciences Program at Harvard who works on using RNA sequencing data to interpret the functional impact of human genetic variation.
Sherif Gerges, Graduate Student
Jack Kosmicki, Grad Student
Jack Kosmicki is a PhD student in the Bioinformatics and Integrative Genomics program at Harvard. He works jointly with Dr. Mark Daly and Dr. Dennis Wall on a number of projects ranging from examining the relationship between genetics and phenotypes in autism spectrum disorders (ASD) to utilizing machine learning algorithms to develop shorter ASD diagnostic tests.
Qingbo Wang
Qingbo is a member of the MacArthur lab, interested in the intersection of large population data and single cell genomics. He completed his undergrad in the University of Tokyo, Japan, and is now in the Bioinformatics and Integrative Genomics PhD program at Harvard.
Liwen Xu, Graduate Student
Liwen worked in the MacArthur lab from 2015-2016, using exome sequencing to identify a genetic diagnosis for over 180 families with late-onset limb-girdle muscle weakness. She has now returned to full-time clinical responsibilities as a medical student at Harvard Medical School.
Sidi Zhang, Grad Student
Sidi is a graduate student in Daly lab. She was born and grew up in Beijing, and did her undergrad at University of Chicago. Her academic interests include population genetics, non-coding regions and psychiatric diseases. She also enjoy Japanese culture, video games, yoga, pets and food.
Undergraduate Students
Alex Pai, Undergradaute Student
Alex is an undergraduate research assistant with Dr. Ben Neale at the Analytical Translational Genetics Unit and the Broad Institute of MIT and Harvard. He is working to identify characteristics of credible sets produced from fine-mapping analyses. Alex joins the Neale lab from Harvard, where he is pursuing a concentration in developmental biology and statistics. Previously he conducted research on neuropsychiatric disease inheritance with Elise Robinson in ATGU and on the molecular mechanisms underlying Parkinson's disease with Lee Rubin in the Harvard Department of Stem Cell and Regenerative Biology.
Brendan Bulik-Sullivan, Alumnus
Laramie Duncan, Alumnus
Karol Estrada, Alumnus
Karol Estrada worked as a postdoctoral research fellow using exome sequencing to investigate the genetic basis of type 2 diabetes, and whole-genome sequencing of patients with neuromyelitis optica. He now works as a research scientist at Biogen Idec.
Kai-How Farh, Alumnus
Francesca Graziano, Alumnus
Melissa Gymrek, Alumnus
Andrew Kirby, Alumnus
Isa Kirk, Alumnus
Elaine Lim, Alumnus
Julian Maller, Alumnus
Joanna Martin, Alumnus
Matthew Aguire, Alumni
Matt is an undergraduate student at Harvard who worked on developing machine learning methods for variant filtration.
Thomas Mullen, Senior Analyst
Tom is a senior analyst for the Broad's Center for Mendelian Genomics, where he has a special focus on the role of regulatory genetic variation in inherited disease. He is also the clinical laboratory director for the Broad Institute's Clinical Research Sequencing Platform.
David O'Connell, Research Associate I
David recently completed his undergraduate degree in Immunobiology at Brown University. He is developing cell lines to study human genetic variation as a research associate in the wet lab.
Shenying Qin, Alumnus
Jaakko Ripatti, Alumnus
Manuel Rivas, Alumnus
Virginia Roth, Sr Administrative Assistant
Kaitlin Samocha, Alumnus
Preeti Singh, Alumni
Preeti was a software engineer developing software tools and portals for understanding loss-of-function variants. She is now working as a software engineer on the Broad's diabetes portal.
Tonis Tasa, Visiting PhD Student
Brett Thomas, Alumni
Brett worked as a software engineer leading the development of xBrowse, an online platform for the analysis of exome data from rare Mendelian disease families built in collaboration between the MacArthur and Daly labs. He is now a consultant software developer. @brettpthomas@gmail
Taru Tukiainen, Alumnus
Elise Valkanas, Alumni
Elise was a computational biologist who worked in the lab on the genomic diagnosis of rare disease families. Prior to joining the lab she worked at the NIH's Undiagnosed Diseases Program. She is now a graduate student at Harvard. @valkanase


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This is book number 1 in the Hunger Games series.
#1 USA Today Bestseller
#1 New York Times Bestseller
#1 Wall Street Journal Bestseller
#1 Publishers Weekly Bestseller
A People magazine (Top 10) Best Book of 2009
A Time Magazine Best Fiction Book of 2009
A Kirkus Best Book of 2009
A 2009 BooklistEditors' Choice
"Whereas Katniss kills with finesse, Collins writes with raw power." -Time Magazine
"Collins has joined J. K. Rowling and Stephenie Meyer as a writer of children's books that adults are eager to read." -Bloomberg.com
"Perfect pacing and electrifying world-building." -Booklist, starred review
"A humdinger of a cliffhanger will leave readers clamoring for volume three." -Kirkus Reviews, starred review
"Forget Edward and Jacob... readers will be picking sides-Peeta or Gale?" -Publishers Weekly, starred review
"Leaves enough questions tantalizingly unanswered for readers to be desperate for the next installment." -School Library Journal, starred review


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Beach Sand Triple Charm Necklace
They say good things come in threes and we couldn't agree more. Three beach sand charms dangle from an 18" stainless steel chain.
Please make sure you send your beach sand to:
We don't need too much sand, a tablespoon in a closed ziploc bag is plenty. After receiving your sand, it usually takes us 3-4 days to make your custom piece of beach sand jewelry. During the summer months, it can take a little longer 4-8 days. Please contact us should you have any questions.


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There are bands, like classic rockers Steely Dan, who until recent years refused to perform live because they knew they couldn't replicate the sound of their studio recordings onstage. Other bands, like the long-running Iron Maiden, don't give a hoot about studio embellishment; their brand of powerful melodic metal rings as true on stage as it does in recorded offerings. The guys know it, too; that's one reason why they don't hesitate to put out live material every chance they get. With there not exactly being a dearth of Maiden concert films, what's different about this one that includes warhorses like "The Wicker Man," "Iron Maiden," "The Number of the Beast" and "Running Free"? A couple of things. Firstly, En Vivo! was recorded almost exactly a year ago during the band's The Final Frontier World Tour and that means this Blu-ray/DVD package provides a first live look at performances of "Satellite 15/The Final Frontier," "El Dorado," "The Talisman," "Coming Home" and "When the Wild Wind Blows," songs from the tour's 2010 namesake album. Secondly, filmed in front of a rabid, starved-for-Maiden audience of 50,000 in Santiago, Chile, En Vivo! literally bristles with energy that the band clearly feeds off of, so much so that never-at-a-loss-for-words singer Bruce Dickinson has to pause and soak it in after "Wicker Man" ends, literally dumbfounded by the roar coming from the elated mass of humanity. When Dickinson does finally speak he likens the rush that the crowd's vibe provides to the one he gets when he "opens up the taps on a Boeing," referring to piloting a passenger jet, something he does in his "other job" as well as for Iron Maiden tours. En Vivo! also utilizes a lot of split-screen editing, mostly just two screens in the early part of the film but quick cuts to three and four screens mirror the excitement as the show gets closer to the end. Otherwise you have here exactly what you'd expect from this well-oiled machine---three screaming guitars, one howling lead singer and a rhythm section that never misses a beat as they pound out a 17-song set that thrills the audience to no end. Iron Maiden is at the point in their career where they could easily rest on their laurels but these road dogs are getting ready to launch yet another tour; those who've seen En Vivo! will no doubt be amongst the first to snap up tickets.
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Iron Maiden - En Vivo! Blu-Ray
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You may recall a while ago that I invited readers to submit any questions they might have to
email@example.com and I would publish some of them in some Ask The Philosophical Muser articles.
I have finally got round to putting some of them together (which was easy as there have only been six or seven thus far), as well as extrapolating some questions/comments/queries I've stored from my time on debating forums.
The questions that appear henceforward in the Ask The Philosophical Muser articles are a heady mix of actual reader questions, varying enquires and feedback that have come my way on social media, and some semi-factual/semi-fictional elaborations where I've taken segments of actual discussions I recall over the years and turned them into fun questions and answers for this Blog. I promise I have taken no liberties that depart from actual questions people have in some way been curious about either in written or spoken conversations.
For the first one, a reader probed me with a very intelligent question that I'd not really thought about in quite this way before. I'm not quoting him verbatim, but the gist of what he asks is this:
Q) If governments are bad when they provide an unnecessary filter between provider and consumer, then why aren't many shops bad when they provide an unnecessary filter between wholesaler and consumer?
A) It's one of those great questions because the logic is pretty robust, it's just that the information needs a little tweak. By which I mean, yes, at face value the logic suggests that any middle men (or middle women, of course) between provider and consumer are going to cream off a share of the value for themselves, because if I want to buy £3000 worth of envelopes from a paper mill via the middle man involvement of a stationery company like Espo, then by the time Espo have taken their cut, I will be paying something closer to £3200 or £3300 for the same product.
But what you don't always get to see about middle men is that they bring to the transaction certain specialities in which they have the comparative advantage, and through which they actually make your transaction with the manufacturer/wholesaler more financially beneficial.
To see why, imagine a baker who is also a pretty good driver with good knowledge of the city in which he bakes. If he wanted to provide a service where he delivered pizzas and cakes around the city, it would obviously not pay him to make the goods and deliver them himself, even if he is a slightly better driver and navigator than the person he hires to do his deliveries.
The reason being; it is more economically efficient for the baker to pay someone else to do the deliveries because what he'd gain in forgone wage costs he'd lose two or threefold in lost opportunity for baking. Suppose in terms of gross profit our baker can make £50 worth of baked good per hour (revenue minus cost of ingredients) and pay someone else £10 per hour to deliver the goods. The baker's profit goes down to £40 per hour, but if the baker spent 3 hours a day doing his own deliveries it would cost him £120 of baking profit to save just £30 of delivery costs.
Similarly, shops are good for consumers and providers alike, because even though the shops have to take their cut as middle men, they have the comparative advantage in things like market research and sourcing information on behalf of consumers. In fact, one can go so far as to say that the fact that the wholesaler chooses the services of retailers shows that the presence of retailers reduce costs by performing actions that would otherwise have to be performed by the wholesalers and the consumers.
As ever, any
questions for this Blog can be sent to me and may become part of the series,
consistent with the four
golden rules:
As ever, any
questions for this Blog can be sent to me and may become part of the series,
consistent with the four
golden rules:
* Please don't ask me to do homework, coursework or an assignment for you. No reader or blogger is interested in that.
* Before asking something, please check the *Labels* section on the right side-bar, as that topic may well have been covered before on here.
* There's no point asking a question about facts or information that you'd be better off typing in Google.
* Please keep your question short. You have a better chance of getting an answer if your question would comfortably fit on a post-it note.


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The ever popular glass colours, perfect for those long summer days and wonderful holidays!
Approx - 12mm and 8mm x 4mm for the spacers.
A total of 15 beads.
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Claris Plush Toy & Book Set
Everyone's favourite French mouse is back with the highly anticipated Claris plush toy!
Learn all about Claris and her adventures with this Claris Plush & Books set! Each set includes:
1 x Claris Plush Toy
1 x copy of Claris the Chicest Mouse in Paris
1 x copy of Fashion Show Fiasco
This super soft Claris plush toy comes dressed in a chic pink tulle ensemble with matching pink silk bow. Claris is wearing her signature gold shoes so you know she is ready for her next adventure!
This high quality plush toy is approximately 40cm in height. Each Claris plush toy comes beautifully wrapped in a Claris the Mouse gift box & ribbon. Each book will be signed by Megan Hess and beautifully gift-wrapped.
Cold hand-wash only. Suitable for ages +3 years.
Please note - the plush toy can not stand by itself.
Claris the Chicest Mouse in Paris - A delightful rhyming tale about courage, compassion and a stylish little mouse, from acclaimed fashion illustrator Megan Hess. Claris The Chicest Mouse in Paris follows an adorable mouse who dreams of moving to Paris to follow her fashion dreams.
Fashion Show Fiasco - When Claris's family leaves behind their invite to Paris Fashion Week, this brave little mouse has only one choice: an exciting dash through the streets of Paris in a race against the clock!


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Fallen football player's mother honors his memory with Cafe 29
Andre Maloney collapsed after long sprint during football game
The mother of a Shawnee Mission West football player who collapsed on the field after scoring a touchdown and later died said her son's life is still making an incredible impact on the community.
Andre Maloney was a happy, vivacious, athletic high school senior when he died suddenly in 2013.
His mother, Rosa Montoya Cardenas, was enveloped by paralyzing grief after losing her only son. But she found strength to carry on by remembering a lifelong dream to open a café.
Just like her son had dreams of playing college football at the University of Kansas and later playing on the professional level, he believed in his mother's dream and had plans to help her realize it.
Café 29 recently opened on 87th Street in Overland Park. Everything inside celebrates Maloney's love of football, friends and family. His football jersey, its number now retired at Shawnee Mission West, hangs proudly on the wall. Images on the ceiling represent his final sprint on the field.
"It's actually the last yard he ran before he passed. Upon arriving at the counter, you score a touchdown," said his cousin, Karla Montoya.
Café 29 welcomes students to hang out, study and enjoy life just the way Maloney did.
Maloney lived to make it big, and for $1, diners can make a wish to also make it big.
"Once you donate a dollar, you get a little Jenga block piece and you write your make-it-big thought," Montoya said. "These are all individuals that have given us their thoughts."
The proceeds from the messages on the wall will go to local charities.
The café exemplifies the things Maloney represented in his short life.
"It's all about the community that's been so supportive to us, so it's a way to say thank you to everybody," said Cardenas.
She said she knows her son would be proud of her.
"Where he is, he is happy," she said.


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Landscape painting notecard of Arizona's Sonoran Desert. Plant species featured in the landscape include Saguaro, Opuntia, Cylindropuntia, Echinocereus & Ferocactus.
Notecards are printed on 100% recycled paper, with a matte texture that is easy to write on. Each card is 5 1/2" x 4" when folded. Card comes with a white envelope, in a protective sleeve.
Also available as a set.


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The Ben Carson crazy
November 5, 2015 3 Comments
Sure, in one sense it might seem rather pointless to catalog the breathtaking levels of inanity and craziness that seem to chracterize Ben Carson's thinking about everything outside of neurosurgery, but this is the man more Republicans want to be president than anybody else at this moment. Now that's scary. The Post's James Downie on the crazy:
The political press is chortling at BuzzFeed's story that Ben Carson believes Egypt's pyramids were built for grain storage, not as burial chambers. "My own personal theory is that Joseph built the pyramids to store grain," he said in a 1998 commencement speech, referring to Genesis 41, which tells of Joseph storing Egypt's grain during the "years of plenty" for the coming famine. Carson confirmed to CBS yesterday that he still believes this, but I'm not sure why this is such a big story. Before Wednesday, we knew that Ben Carson takes the Bible literally. After Wednesday, we knew the exact same thing. Frankly, I don't care whether the president believes the pyramids were built by Joseph, aliens or the Egyptians themselves levitating the stones into place. What matters are the ideas — and that's where the focus should be with Carson, since it's clear he has no idea what he's talking about.
In the same week, Carson also said that Medicare and Medicaid fraud is "huge — half a trillion dollars." If true, that would be almost 50 percent of our total spending on the two programs. The real number is somewhere between 3 and 10 percent — still a problem, but handing the program to a Carson White House would be like handing the drug war over to someone who believes half the United States is hooked on heroin. In the same Miami Herald interview, Carson was completely stumped by basic questions on U.S.-Cuba policy, before having no qualms about holding forth on the president's Cuba policy.
And on Wednesday night on Facebook, Carson defended his lack of experience by claiming, "Every signer of the Declaration of Independence had no elected office experience." That is utterly false…
As more and more debates have passed this fall, several commentators havesuggested moderators should retire more confrontational questions (such as "Is this a comic book campaign?" or "another candidate said something bad about you last week; please respond") and ask more basic things like, "Should the Federal Reserve raise interest rates?" Carson's lack of knowledge backs up this strategy: If you ask him a more confrontational question, he can just brush it off as an attack by the lamestream media. But give him a wide berth, and he'll expose his own ignorance. Carson's words clearly show he will trip up all by himself.


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| Update: 2020-02-14
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A new report titled 'Ghana: what economic challenges' published by the Agence Française de Développement (AFD) has revealed that the country's exposure to capital flight remains high due to the large portion of public debt held by non-residents.
According to the report, non-residents alone hold about half of the country's domestic public debt in the local currency. A similar percentage of non-residents also hold foreign currency-denominated public debt.
It is against this background that the AFD is warning of a possible capital flight if non-resident holders of the country's debt find other economies attractive for investment.
"Ghana is highly exposed to capital flight risk… Newly incurring public debt is mainly in the form of non-concessional external foreign-currency debt. In light of these elements, Ghana appears vulnerable to investors' changes of confidence and to fluctuations in the exchange rate. Ghana will have to face high financing costs on internal and external markets in the context of a strong American dollar and the rise in global bond yields," the AFB report said.
Aside from the risk to capital flight, the report added that the country is at constant risk of currency depreciation if non-residents keep holding a large portion of the public debt.
"The depreciation is largely attributed to international factors such as the appreciation of the USD, the effects of the United States' tightened monetary policy and the rise in Fed interest rates. Thus, a possible non-resident withdrawal from the Ghanaian domestic bond market, due to a preference for investing in USD assets, would run the risk of weakening the cedi exchange rate in the medium term," the report said.
The report comes on the back of similar concerns expressed by other policy think tanks and financial analysts. The Institute of Fiscal studies (IFS), for example, has cautioned government against the increasing external debt, saying: "steps must be taken to limit the country's exposure to fickle foreign investors in the domestic debt market."
A Summary of Macroeconomic and Financial data published by the Bank of Ghana show that the public debt has hit record high of GH¢200 billion in May 2019 from GH¢198.4 billion in April. Out of this, the external debt component makes more than 50 percent (GH¢105 billion), also representing 30.6 percent of GDP.
The data further show that, while the external debt component increased by GH¢900 million between April and May 2019, domestic debt increased by GH¢600 million – representing 27.5 percent of GDP, a situation that the Governor of the Central Bank, Dr. Ernest Addison, says makes the economy vulnerable.
"If you have quite a bill of external debt stock and you have significant non-resident holdings of your debt, you are vulnerable to movements in exchange rate. So the discussion really should shift away from questions of sustainability to an assessment of our vulnerability.
We recognise that we are vulnerable. We are vulnerable because the foreign exchange component of the debt is significant—both the external component of the debt and then non-resident holdings of our debt. That is where the vulnerability comes in," Dr. Addison told journalists in Accra last week.


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Washington, DC (LifeNews.com) -- The pro-abortion political group Emily's List started a new national campaign today designed to attack pro-life former vice-presidential candidate Sarah Palin and the slew of pro-life women candidates she is supporting across the country in this year's congressional elections.
The group's president, Stephanie Schriock detailed the "Sarah Doesn't Speak for Me" campaign during a press conference at the National Press Club today.
The campaign will focus on a web site chronicling statements from Palin and pro-life women candidates like Senate nominees Carly Fiorina, Sharron Angle and others that the pro-abortion groups condemns...
Washington, DC (LifeNews.com) -- Tuesday's primary elections saw the political landscape in a few states move in the direction of pro-life women and one pro-life organization is delighted by the results. With Carly Fiorina's Senate victory in California and Sharron Angle's in Nevada, pro-life women are now on center stage.
Former Hewlett-Packard CEO Carly Fiorina will face Sen. Barbara Boxer, the leader of the pro-abortion forces in the Senate, this November.
Fiorina cruised to an easy victory in the race for the Republican nomination defeating pro-abortion former Rep. Tom Campbell and pro-life state Assemblyman Chuck DeVore. She took home 54 percent compared with 26 percent for Campbell and 19 percent for DeVore...
Washington (AP) - Once, California Democrats led the way to a year of the women. Now, nearly two decades later, Republicans hope it's their turn.
Meg Whitman won the party's nomination for California governor on Tuesday and Carly Fiorina will carry the GOP banner into the fall campaign for a Senate seat, a pair of wealthy businesswomen and first-time candidates running against veteran politicians in a year of palpable anti-establishment sentiment.
In next-door Nevada, a third woman contender, Sharron Angle, won the right to oppose Senate Majority Leader Harry Reid in the fall...
The Republican state lawmaker is running against former Hewlett Packard CEO Carly Fiorina in California for a chance to square off against Democratic Senator Barbara Boxer in the general election. He says his GOP opponent embraces big government policies that involve "more borrowed money that our children can't repay."
California Republican U.S. Senate candidate Carly Fiorina last week gained the endorsements of eight Republican Senators, including Minority Leader Mitch McConnell, Tom Coburn, Susan Collins, Lindsey Graham, Jon Kyl, John McCain, Lisa Murkowski and Olympia Snowe.
In doing so, the eight Senators looked past the more conservative candidate challenging Fiorina in the GOP primary - State Assemblyman Chuck Devore, who is a Lt. Col. in the U.S. Army Retired Reserve, and was a Reagan White House appointee in the Pentagon.
DeVore says Fiorina believes in a different scope of government than he does.
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These Viral 10+ Pictures Of Women Removing Their Makeups Will Leave You With Serious Trust Issues
It's a fact that beauty standards and different perceptions vary a lot across the world, not to mention that each person has his own understanding. After the rise of social media, the cult of beauty became so important that some people even go an extra mile to look pretty just for the appearance on the internet.
In different parts of Asia, e.g. China, some people reach the whole new level of creativity regarding this matter. For some girls, makeup now means not only just highlighting their existing features but also creating new ones with the help of fake skin extensions, fake eyelashes, etc.
The video below, that went viral a few days ago, shows the process of Asian girls removing their "sculpted" faces, and most of them become completely unrecognizable. Scroll down to see it for yourself and let me know your opinion about this in the comments below!


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This class will cover the ins and outs of event planning. This is where we will learn about choosing the right date choosing the right act, or choosing the right venue for the goal you're trying to accomplish. Learning to set up an artist rotation to make booking easier.
Class will be held in voice and students will be expected to show up 45 minutes prior to an event so class can start on time.
Wednesday, September 14, 2011
RUC: Event Management -Planning an event starts @ 4:15 PM PDT
Posted by Jwheels Carver at 12:10 PM
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Perhaps I am too serious and somber, but I just cannot find the fun and frivolity in journalists playing April Fool's Day pranks on their readers these days.
I know of at least one April Fool's Day "joke" column in today's Star. Having written my own column a couple of days before this annual celebration of pranks and practical jokes, there may well be more high jinks at play for you today that I was unaware of before my deadline. Certainly, there are many journalists at the Star with a better sense of humour than me — and perhaps they are less grim about the grave dangers to our credibility of fooling readers with pretend news for even just one day.
Truth is our currency — the foundation of our credibility. In this time of concern, confusion and complaints about fake news, why would we present false news as real and seek to fool readers into believing something that is untrue is true? Just for laughs?
I know we can all use a good laugh most any day, but with trust in the media at an all time low, and a United States president happy to try to delegitimize journalism, this would seem to be a time to step back from the tradition of media organizations making mischief with made-up stories on April 1 and remember that the Toronto Star is definitely not The Onion, the farcical U.S. newspaper and website.
Have you found the April Fool's Day column published in today's Star or are you now outraged about the cruelty of cats? If so, please consider the calendar and don't call the public editor. And if there is some other playful prank published elsewhere in the Star, I don't want to hear about that either. Likely, I won't be amused.
To be fair, the tongue-in-cheek column I was informed about earlier this week is relatively innocuous. I do not have significant concerns about its publication. It is not the news sections and it's not pretending to be news. I think you will figure out that it is a joke fairly quickly and allow yourself a smile and chuckle.
Inevitably, the fact that it is April Fool's Day will lead to some confusion for readers in any event. Most years, there is some strange, but true, story published on April 1 that leads to readers questioning whether it was an April Fool's joke. Indeed, some of the real news from the U.S. these days often does read like a bad joke.
Certainly Star journalists will need to be vigilant today not to report April 1 hoaxes carried out by others as real news. In recent years, many corporations have hoped to make headlines with elaborate April Fool's Day ruses. Remember, a few years back when Ikea recalled its erroneously issued "left-handed Allen key," which must be swapped for the correct right-handed version?
The Star has not resisted the call to play the joker on April Fool's Day of past. On April 1, 1976, our front page carried a picture of King Kong clinging to the top of the CN Tower. In 1979, Star columnist Frank Jones wrote that prehistoric creatures were being driven by radiation out of Lake Ontario onto the shores of Ward's Island.
Other April 1 jokes sought to fool with false images — a streetcar on the Gardiner Expressway, a whale in Toronto harbour with a photo caption telling readers, "the huge mammals are being lured to the Great Lakes by unseasonably warm weather," a "new million-dollar Leafs rookie" suited up for play: then 80-year-old team owner Harold Ballard.
These pranks were played in a long tradition of April Fool's jokes by media organizations. In 1950, the Honolulu Star-Bulletin reported that a flying saucer had crashed into a crater on the island of Oahu. In 1971, France's state-run radio announced the country would switch to driving on the left side of the road. In 1975, The Times of London reported that the U.K.'s largest travel company, Thomas Cook, was selling $575 round-the-world trips to see the newly discovered remains of Scotland's Loch Ness Monster. In 1980, the BBC told the world that the Big Ben clock was going digital.
My favourite story from the April Fool's files was a newspaper in the Netherlands that told its readers one April 1 that on that day it had started to use a new ink that smelled like tulips. Not surprisingly, some noses were out of joint by that prank.
Admittedly, those were all amusing efforts. But that was then and this is now, a time when we know media credibility is at stake. In this digital era when information spreads around the globe in seconds and lives on forever online, serious news organizations should not play around with far-fetched fake news just for laughs.
After all, the news is serious business. I'm not kidding you.


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War Vets on Zim-Asset
War veterans in Hurungwe District meet tomorrow in Karoi to discuss ways in which they can contribute towards the successful implementation of projects under the Zimbabwe Agenda for Sustainable Socio-Economic Transformation (Zim-Asset).
War veterans from Chirundu, Kariba and Karoi are converging at Karoi Junior School for the meeting which starts at 10am. Secretary-general of Zimbabwe National Liberation War Veterans Association in Hurungwe District Cde Donny Nxele said the meeting was meant to educate the war veterans in areas of the Zim-Asset blueprint where they can make meaningful input in their locations.
"We want war veterans and widows and widowers of war veterans in our area to learn and contribute towards Zim-Asset as you know that we support Government policies," he said.
"As patriotic citizens who fought to liberate this country, we want our economy to be boosted through the successful implementation of this economic blueprint. War veterans are known for making sacrifices and I am sure if we work hard like what we did during the liberation struggle, Zim- Asset will produce the desired fruits," he said.
Cde Nxele said the meeting was also meant for war veterans in the district to meet the War Veterans Trust leadership and to know how members could benefit from the trust. He said the meeting would also discuss the welfare issues affecting war veterans, their widows and widowers.
"We want to capacitate war veterans in our area on how they can benefit from programmes like Government inputs among others. If we produce more food for the country, surely we will have contributed immensely towards the successful implementation of the blueprint," Cde Nxele said.
Source : The Herald


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Just Add Water
Sunday, September 25, 2005
New kitten of the week
Senorita was adopted today. I'm thrilled for her, but it's still quite sad. I didn't want to give her up! Gracie went to a different foster family this afternoon, and I came home with a completely different kitten. Her name is Cindy, and she's a gorgeous gray cat with multi-colored toes. I don't have a picture yet, and she's not on the
Animal Allies
website. She's just three wee months old, and so tiny! Her little meow is just barely a squeak! Hopefully, she'll find a permenant home next Sunday. I'll try to get a picture of her in the meanwhile.
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When many people think about Intel, they think about silicon and only silicon. While there is good reason for this view—Intel is renowned globally for its relentless innovation in microprocessors—Intel is actually about far more than silicon. Intel is, in fact, also very much a software company with a sharp focus on driving advances in data analytics with a huge commitment to open source software.
Prior to joining the company in 2015, I pretty much shared the prevailing view of Intel throughout my career. I entered the tech industry as a software engineer and then moved into the entrepreneurial realm, founding and running tech companies. Throughout my career, I thought of Intel as a world-class company that made the infrastructure at the bottom of the IT stack.
And then came my conversations with Intel, which led me to my current role leading big data solutions business development. Through this process, I became intimately acquainted with the work Intel is doing to accelerate the development of innovative solutions for data analytics that span the silicon and software stack.
Intel has a long and successful track record for investments in open source software initiatives and new technologies, including, in recent years, big data. Let's consider some examples:
- Intel invested early on in driving advances in the open source Apache Hadoop platform for storing and processing big data in its many forms—from social media to transactional systems. To that end, Intel has made a significant investment in Cloudera, a leader in Hadoop solutions.
- Intel technologies for data analytics are at the heart of many solutions for precision medicine—such as solutions that analyze data from an individual's genome to develop narrowly targeted treatments for cancers.
- At the Oregon Health & Science University, cardiologists leverage the Trusted Analytics Platform to analyze big data from wearables in a clinical study that merges 24x7 lifestyle data with wearable devices, home monitoring devices, and clinical records.
- Intel innovations are all over the Internet of Things (IoT), from drones that capture and transmit data pertaining to the land below to the snowboards of world-class athletes. At the X Games Aspen 2016, the Intel Curie compute module was embedded directly on athletes' snowboards to capture everything from speed and jump height to air time and numbers of rotations—all in real time in an effort to enhance the viewing experience for fans.
These are just a handful of examples to illustrate the bigger point: Intel is not just inside servers, desktop computers, and mobile devices; analytic investments and innovation from Intel are present in all layers of the IT stack—from infrastructure to applications.
Without analytics, big data isn't worth the media it's written on. You can't do anything with it. But with today's advanced analytics tools, you can put data to work to save lives, improve athletic performance, drive better business performance, and make countless other things possible.
I've spent the past six years excited about and motivated by the potential of big data, and I'm equally excited about the work we are doing here at Intel to help organizations and individuals realize the benefits that emerge at the intersection of massive amounts of data, advanced analytics tools, and high-performance processors.
You can expect to hear much more from me on these topics in the weeks and months ahead. In the meantime, if you're heading to the Strata + Hadoop World conference in San Jose this week, you can get a close-up look at some of the exciting work that Intel and its partners are doing to help organizations accelerate the value to be derived from big data via analytics.
And if you're ready for a deeper dive right now, you can get a look at some innovative use cases for big data—from smart clouds to more precise farming, from heart-health programs to cancer research labs—at the Intel New Center of Possibility site. And to dive down into the capabilities of the Trusted Analytics Platform, visit trustedanalytics.org—and learn how you can close the gap between big data and the applications that need to consume the data to deliver value.


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Great music his voice awesome best singer ever best o
Hello from Belgium ! I recently discovered the music of Kip Moore through YouTube. First I listenend to a couple of his previous songs, which were really good. A couple of days ago I watched the documentary "7 days at the rock" and loved it, very interesting to see. I found out Kip just released a new album, Wild World. I listenend to it and I have to say, this album is simply amazing. Kip is an outstanding singer, great voice. The way he puts his heart and soul in every song, really gets to me. He is very authentic.
I will definitely keep following his music, that's for sure. And I hope one day I will be able to see him perform live.
Greetings, Ibrich
New album is so good. Gave me chills , it's so raw but too the point. Best One Yet. Could always trust you to give it 100 % for your fans. So thank you for staying true to yourself and your music.
This site is the worst. No one ever responds to member questions. If their is someone actually running this useless site you need to lose your job.
Hi, can't see whether my original comment posted. Having an issue with the album sale links. When I click them, it's opening a new window to the UMG website with no further option to purchase the album/packages. It's not an isolated incident as my friends are having the same issue. Have tried it on different devices too and on different days in case it was just a glitch but it is still occurring. Any help would be greatly appreciated. Thanks :)
I'm in Australia and tried for weeks to order, couldn't get the screens to open on phone or computer. In the end I had a friend in Nashville order the CD and album for me, I'll get them whenever I can fly over again.
There's an issue with the presale links on the website. Everytime they are clicked it is opening a new window to the UMG website with no option to buy the record. Can someone have a look at this please? A few friends have confirmed they are having the same issue. Thanks.
My husband and I love Kip! Best concerts we've experienced have been with Kip!! So genuine and badass!! I hope one day we get to have a VIP meet and greet because we'd love to party with Kip one day!!!!!
We love you Kip! Hope we get to see you soon! ❤


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Cambrex Corp. (CBM) reported that its fourth-quarter GAAP EPS from continuing operations increased 4% to $1.20 from $1.15, last year. Adjusted income from continuing operations was $42.4 million or $1.27 per share, compared to $40.8 million or $1.23 per share in the same quarter last year. EBITDA increased to $64.7 million compared to $63.6 million in the same quarter last year. On average, five analysts polled by Thomson Reuters expected the company to report profit per share of $1.12 for the quarter. Analysts' estimates typically exclude special items.
Fourth-quarter net revenue increased 2.5% to $182.3 million compared to $177.9 million in the same quarter last year. Excluding the impact of foreign exchange, net revenue increased 1%. Analysts expected revenue of $184.4 million for the quarter.
The company expects 2018 adjusted net revenue, excluding the impact of foreign currency and change in accounting principle, to be between -2% and 2% compared to 2017 and adjusted EBITDA to be between $150 and $160 million.
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text: Restaurant Author: Aaron Tristan - September 13, 2018 Opening Franchises are Perfect for First Time Business Owners Are you an entrepreneur who is looking to own your own business? There are many who would like to own their own business, but lack the experience to guarantee success…. Read more Share Twitter Facebook


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Via One Mile at a Time, there is a very easy way to earn 500 Marriott points.
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Marriott points expire after 24 months of account inactivity. However, I doubt this promotion will qualify as account activity and extend the life of your points. Because Marriott says:
The following activities do not count toward maintaining an active status in the Marriott Rewards® program:
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And if you're not already, you can follow us on Instagram as well!


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Harrogate Grammar School Positive Achievement sign now
We, the undersigned, hereby declare that the Positive Achievement system in use at Harrogate Grammar School is ruining the positive work atmosphere once enjoyed at the school.
Due to the overuse of automatic Negative Comments, a so-called system of praise and excellence has become an omnipotent system of fear, adding to exam stress and causing the school day to be filled with dread and unhappiness where a culture of achievement and success should instead stand.
The system, meant to bring uniformity and consistency to the way achievement is measured, has instead extrapolated the sheer discontinuity between the amounts teachers are willing to praise students. One teacher may give three whole credits (9 stamps) for an act that another teacher would give none. The same goes for negative comments, with many teachers overlooking minor infractions and others issuing negative comments for trivial problems such as arriving to registration mere seconds "late" (late in this case being defined as from the moment at which said hypothetical teacher started to call the register, and NOT once the second bell has rung)
We believe that the elevation of the planner to the status of a "passport to learning" (the lack of one being the passport to Isolation) is frankly absurd; consider keeping a paramedic isolated from their ambulance during an emergency call because they failed to bring a means to write down what paperwork to do over the evening.
We also believe that, in many cases, quantifying success rather than qualifying it has led to the "high achievers" in school being the ones that have the most lenient teachers, and do the most errands (as they often contribute more stamps than work as of late), rather than those that are overachieving and contributing positively to the life of the school.
We feel that the school, which is known to be one of the best in the country, deserves a much better system, and that prolonged use of the current regime will lead to its downfall. Already, many students are complaining about the negative atmosphere in the school that the so-called Positive Achievement scheme has ushered in, and how the previous scheme was much less stressful and draconian. We therefore feel drastic action is necessary to incorporate more of the students' ideas into the system, or to scrap it altogether in favour of a system more akin to the "old way" of marking success.
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Harrogate Grammar School Senior Leadership Team
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