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Vitamin K supplementation for meat quail in growth of 1 to 14 days old
The experiment was carried outto determine the levels of vitamin K for meat quails (Coturnixcoturnixsp) from 1 to 14 days of age. Atotal of 2200 birds were used, complete by random experimental design, with 8 treatments, 5 repetitions and 55 meat quails per experimental unit. The levels of vitamin K supplementation were 0; 0.7; 1.0; 1.3; 1.6; 1.9; 2.2; 2.5 mg/kg diets. The performance was measured through weighing weekly from the birds and feed, and at the end of the experiment was carried out collects blood and bones for the assessment of bone quality parameters. The levels of vitamin K supplementation had no influence on performance orbone quality, except thatthe bone density and calcium concentration of the femur and the bone density of the tibia showeda quadratic effect, with estimates of 0.98; 0.92 and 1.18 respectively. The length of the tibia showed a linear increase according to the levels of vitamin K. There was no effect in the concentration of serum calcium, but there was a quadratic effect in the concentration of alkaline phosphatase. The vitamin K supplementation did not affect the performance of the meat quails from 1 to 14 days of age, showing that the amount of vitamin K present in ground corn and soybean meal-based diets is sufficient to meet the needs of the birds' performance.
Full Text:PDF
DOI: http://dx.doi.org/10.5433/1679-0359.2015v36n6p4003
Londrina - PR
E-mail: firstname.lastname@example.com


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Theme revealed for HDAW 2019
LAS VEGAS, Nev. — Heavy Duty Aftermarket Week '19 (HDAW 2019) conference organizers have announced "Connecting to the Future" as the theme for the annual conference to be held Jan. 28-31, 2019 at the Mirage in Las Vegas.
"We looked at our industry's primary challenges, from both the supplier and distributor angles, and will focus the education program on bridging concerns to solutions," said Brett Penzkofer, vice-president, North America aftermarket for Meritor.
"In 2019, HDAW is going to focus on customers, employees, products, and technologies, and the issues that keep us up at night," said Ian Johnston, v.p operations and marketing for Harman HVS. "We want to identify and confront business pain points with resolutions that we can actually use."
HDAW is a business-to-business, executive conference presented by a joint operating committee of industry leaders from 12 industry associations.
For more information, go to www.hdaw.org, contact W.T. Glasgow, conference management, at 708.226.1300.
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Canton, Mass.-based Gray Gray & Gray LLP (FY13 net revenue of $14.3 million) and Green & Green LLC of Dedham, Mass., announced their merger, effective Nov. 1. The combined firm will operate as Gray Gray & Gray LLP, with consolidated offices located in Canton. The staffs of both firms will be retained in the merged entity, which will employ a combined total of nearly 120 team members.
"We are very pleased to be joining forces with Green & Green, and look forward to working with their outstanding staff and clients," says Joe Ciccarello, MP of Gray Gray & Gray. "We have taken this step for many reasons – primary among them being our desire to provide our clients with a wider and deeper range of services. Our combined talents and abilities mean our clients will benefit from a more comprehensive scope of accounting, tax strategy, business advisory and wealth management services."


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Picking The Best Lighting For You
Lighting is one of the important things that you have to keep in mind with regards to your home improvement. There is an additional aesthetic value that can be added to your property when there is an excellent lighting that can be observed. In case that you have the idea of selling your house in the future, it is apparent that you can take advantage of it then. In order for you to learn more on what certain lighting you have to acquire for your home, here are some of the things that you need to remember.
You will be able to find a lot of lighting options for your home that are highly suggested by experts. With this, you can take advantage of choosing from these options.
Going for lighting that has abstract designs is a great move to do when your interior design at home has a touch of abstract. You cannot only come up with a suitable lighting for your interior design but you can also acquire the proper illumination in your abode. There is a guarantee that you can find in the market a wide array of this lighting. From the wide array of choices pertaining to hues, shapes and accents, it is possible for you to choose for the most ideal one for you. When you choose to get for this type of lighting, there is an assurance on your part that you can have both effective and decorative. You just have to give time in visiting the market so as to learn more about this lighting.
On the other flip side, when you don't want to adhere with the first option that is being presented, you will be appalled to know that there are plenty of options available in the market for you. In case that you are looking for a country touch lighting, it is ideal for you to adhere with a country-inspired one that has a touch of sophistication. There is simplicity that can be observed in this style of lighting but then it is elegant for your abode.
It is important that we give time in choosing for the right lighting to be used for our abode because aide from giving the proper illumination for our home, we also add beauty into it. In order for you to have the guarantee about the certain lighting to be installed for your home, you need to know more about it then before you come up with the decision of having it at home. In doing so, you can take benefit in doing a little research about it. For you to get the information pertaining to the lighting that you wish to acquire, it would be ideal for you to use different websites then.
More ideas: page


text: Profile More Info Area: North Ocean City Photos Map No Records FoundSorry, no records were found. Please adjust your search criteria and try again. Google Map Not LoadedSorry, unable to load Google Maps API. Driving Walking Bicycling Public Transport Miles Kilometers Reviews 1 Review on "Fenwick Inn" Holly Shellenberger Fenwick InnMarch 28, 2019 at 5:02 pm more We love this place,it's relaxing, friendly,clean and everything you need in one place ,and most of all our fur baby felt right at home being there,we would recommend this place !!! Reply ↓ Leave a Review Cancel replyYour email address will not be published. Required fields are marked *Review text * Rate this Hotel (overall): TerriblePoorAverageVery GoodExcellent Name * Email * Website Area Area: North Ocean City Related Businesses Previous Next


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Visual Abstract - Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure: 10.1016/j.jacbts.2018.11.001
2019-06-13T11:02:10Z (GMT) by
• Systemic treatment of an antibody-based glucagon receptor antagonist confers cardioprotection against myocardial infarction and post-myocardial infarction remodeling in mice.
• Systemic treatment of glucagon receptor antagonist prevents pressure overload induced cardiac remodeling and dysfunction in mice.
• Glucagon receptor antagonist treatment attenuates the pathological progression of heart failure induced by pressure overload in mice.
• Long-term suppression of glucagon signaling is potentially an effective therapy for heart failure with different etiologies independent of metabolic disorders.


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Gadget Review
10 Reasons To Love Samsung Galaxy A7 2018 (Review)
By TianChad田七 - December 28, 2018
[PHOTO] Reasons To Love Samsung Galaxy A7 2018 (Review)
Here comes the long overdue review post about the triple camera Samsung Galaxy A7 2018 Edition. I've got the Blue Color Samsung Galaxy A7 with me and played with me for month before I can justify on the camera quality. Hence below will have a series of photos taken using the Galaxy A7 (2018) and my main focus would be about the new addition of Ultra wide-angle 8MP camera, why and where you will need the extra wider view for photoshoot.
I shall give a quick conclusion of my Galaxy A7 (2018) user experience in points below:
- A well hidden fingerprint sensor at the power button area that I just noticed recently. It was not at the back/front of the screen but at the convenient place of the power button. All I need to do is place my thumb on it.
- Triple Camera with 8MP Wide Camera being the most useful addition to A series, followed by the 5MP camera for Live Focus
- Overall phone performance is good, can play games well. (Eg. Ragnarok M Eternal Love)
- Overall camera HDR function is superb, especially when it able to detect human faces and photo still looks overall good even if it is backlight (eg. sunset). Check out the photos below
- Live Focus effect with blur/bokeh background is good, but it is not perfect in differentiate the object and background yet. The background and lighting condition will justify the result
- Scene Optimiser smart camera mode that helps enhance to make your photos look much better in just one click.
- AR Emoji - Emoji creator that you have at Samsung S series smartphone to create customized emojis
- 128GB huge built In memory, can insert additional Micro SD Card up to 512 GB.
- 6.0" FHD+ Super AMOLED Infinity Display good for visual content viewing experience.
- Can put Dual Sim cards beside an additional Micro SD Cards, makes travel to oversea easier.
- With Dolby Atmos Audio Experience (works with earphone and bluetooth headset)
- Phone cover is provided in the Manual Box, no need to shop for new case to protect your phone
- With new OS update, it now has Super Slowmo feature, can adjust exposure for Wide Angle camera (previous version can't)
- Almost all phones are with USB-C charging port but A7 2018 still using the normal USB Port. No fast-charge features unfortunately.
- The Super Slowmo doesn't have auto capture mode. Hence harder to capture that split seconds of slow motion if you missed it. However it is good that Samsung included it.
- Lowlight photos are pretty great, check out the photos below. Tips: Snap a few more time to make sure you've got clear shot.
- Has earphone jack - You know what I mean
- Camera doesn't have OIS, so you need to train your hands for consistent stable shots.
- Affordable retail price at only
RM1299RM1,099 (They have revised the price recently). Can buy it online at only RM1050.
[PHOTO] Reasons To Love Samsung Galaxy A7 2018 (Review) Here comes the long overdue review post about the triple camera Samsung Ga...READ MORE


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Explore the plethora of resources our state offers with this extensive directory of programs and incentives as well as service organizations and facilities available here in our state for building business and economy.
Crowdfunder is an equity-based crowdfunding platform for small and startup businesses. Read More
Indiegogo is a donation-based crowdfunding platform that is popular among nongovernmental organizations and nonprofits as well as projects. Read More
Kickstarter is a donation-based crowdfunding platform for creative projects. Read More
Quirky is a donation-based crowdfunding platform for projects focused on product development. Read More


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Real Estate Partner
Leading Legal 500 Firm
Top York firm seeking a Real Estate Partner for their state of the art office.
You will join one of the largest and most highly respected teams in the York area. You will work with a range of business sectors acting for developers, investors, funders, pension funds, institutions, landlords, tenants and retailers.
This role would suit either a senior candidate looking for a step up in terms of responsibility, who has hit a glass ceiling of progression in their current firm, equally this could be an excellent opportunity for a Real Estate Partner seeking a role within a Real Estate department who are performing above the rest of the competition with a focus on all aspects of real estate matters including finance, charities, developments and asset management.
You will work at the forefront of this growing team, working alongside the other Partners to drive the department forwards. You will deal with a broad range of work of varying sizes and industry sector, which will make for a much more interesting role, the work will include; Development work, Landlord and tenant, Commercial sales and purchases and Commercial Leases.
As you would expect for a role at this level, working with existing clients and winning new business are also key aspects of the role. For this reason you should have proven client facing skills demonstrated by the ability to bring a number of your current clients with you to a new firm.
If you're an experienced real estate senior associate or partner looking for a new role in the York, this opportunity will certainly interest you.
For more information about this, and other roles that I am recruiting for in Leeds, please contact Ben Brockman at Search Legal on 0113 308 8018 or email firstname.lastname@example.com
Search is an equal opportunities recruiter and we welcome applications from all suitably skilled or qualified applicants, regardless of their race, sex, disability, religion/beliefs, sexual orientation or age.


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Hachinohe and Morning Markets
In downtown Hachinohe, there are many neighborhoods that were named after the day of the market that was held when Hachinohe thrived as a castle town, such as Mikkaimachi (3rd-day town) and Youkamachi (8th-day town). It is said that these remnants of the market days, when the streets were bustling as fresh vegetables and seafoods brought in from nearby farming and fishing villages were sold, are the origins of the morning markets that we see today all across the city.
Tatehana Ganpeki Asaichi
(Tatehana Wharf Morning Market)
Tatehana Wharf Morning Market is a massive morning market on a vast wharf that is only open on early Sunday mornings. More than 300 vendors line the 800m-long market, and it is one of the largest markets in Japan with over 10,000 visitors every week.
Whatever you are looking for, you will most likely find it here - the market sells practically everything: seafood, such as Hachinohe's fresh and dried fish, vegetables, fruits, flowers, as well as a variety of side dishes, and there are also many coffee shops and vendors that sell pastries, baked goods, knives, antiques, sewing machines, and much more. Visitors enjoy their time at the market in a variety ways, such as buying breakfast or chatting with a friend.
Visit the huge, breath taking Tehana Wharf Morning Market, and spend a morning that can only be experienced in Hachinohe.
|Tatehana Wharf, Shin-Minato, Hachinohe City
|0178-27-3868 (Minato Sunday Morning Market Cooperative)
|Open every Sunday, March 18 – December, from dawn until around 9:00 AM.
* The market is open on special days during the Obon and New Year's holidays.
* The market will be open on Thursday, May 3, 2018.
* The market will be closed on Sunday, May 13, 2018, for the Umineko Marathon.
* The market will be open for two days for the Obon holiday, on August 11 (Sat) and August 12.
|Regular Holidays
|Closed from January through mid-March
|By car: 20 minutes from Hachinohe Expressway, Hachinohe IC, 25 minutes from JR Hachinohe Station, 10 minutes from downtown Hachinohe
By train: 10-minute walk from JR Hachinohe Line Mutsuminato Station
By bus: Isaba Sunday Morning Market Loop Bus - "Tatehana-gyoko-mae" bus stop
|500 spaces
Unique finds at Tatehana Wharf Morning Market
Gummy Larva(1):Life-like appearance and texture have made this gummy larva very popular. Hurry before they are sold out!
Gummy Larva(2)
Fishermen's exfoliation net:Purchase an exfoliation net at the morning market and make your way straight to the bath house!
Deep-fried food:Long-queues and bulk purchases are common sights at deep-fried food vendors.
Steamed soup dumpling:The steamed soup dumpling vendor is worth lining up for. Bite into the dumpling and savor its juicy filling.
Bread: There are multiple bakers as well. Their breads sell out very quickly.
Fruits(1):Apples and pears harvested in nearby areas are sold here. Their locations and displays are quite unique.
Grilled fish: And of course, there is the charcoal-grilled fish that is the specialty of Hachinohe.
Ikadon: The mysterious, unofficial mascot of Tatehana Wharf Morning Market. It seems like it has a family. The one in the photo is "Mother Ikadon."
Mutsuminato Ekimae Asaichi
(Morning Market in front of Mutsu-Minato Station)
Mutsuminato Station Morning Market has served as the kitchen of Hachinohe ever since the end of World War II. With the Hachinohe Municipal Fish & Vegetable Retail Market at its center, retailers and wholesalers line the Ekimae Street where the morning market takes place. This morning market, where the voices of "Isabanokaccha" (the local name for women who sell fish) and the idyllic atmosphere of the port fill the air, becomes a vibrant place packed with chefs purchasing ingredients, locals, tourists, and many other visitors.
The best part of Mutsuminato Morning Market is the original breakfast you can create by combining the sashimi and side dishes that you just purchased from the market with rice and miso soup. Having breakfast in the market is a uniquely special experience.
|In front of Mutsuminato Station, Minatomachi, Hachinohe City
|0178-33-6151 (Hachinohe Municipal Fish & Vegetable Retail Market)
|3:00 AM-12:00 Noon
|Regular Holidays
|Sundays, New Year holidays (The Hachinohe Municipal Fish & Vegetable Retail Market is also closed on the second Saturday of the month)
|By car: 20 minutes from Hachinohe Expressway, Hachinohe IC, 25 minutes from JR Hachinohe Station, 10 minutes from downtown Hachinohe
By train: Near JR Hachinohe Line Mutsuminato Station
Bus: Hachinohe City Bus / Nanbu Bus - 3-minute walk from the "Kaminakamichi" bus stop
|No parking (Parking is available in the neighborhood)
What you need to know for "Asameshi-dokoro Uosai" at Hachinohe Municipal Fish & Vegetable Retail Market
-10 Rules for Morning Market Breakfast-
No. 1: Go between 5:00~10:00 am on weekdays and Saturdays.
No. 2: Purchase sashimi, side dishes, etc. at the market.
No. 3: Don't buy too much just because it is cheap. If going in a group, sharing is the way to go.
No. 4: When buying fish roe, such as cod roe and salted salmon roe, try asking, "Can I have 100-yen worth of the roe"? You'll sound like a market pro!
No. 5: Get great deals while enjoying a conversation with Isabanokaccha (women selling fish).
No. 6: Once you have purchased sashimi and side dishes of your choice, head on to "Asameshi-dokoro Uosai" at the back of the market and purchase rice and miso soup to complete your own morning market breakfast!
No. 7: Types and prices of miso soup will vary by day. Enjoy the season's best soup!
No. 8: Check out which freshly grilled fish is available, and order if there is still space in your stomach.
No. 9: Express your gratitude for the bounty of Hachinohe's ocean by savoring the meal to the last bite.
No. 10: Finish off your dining experience with coffee or the local "Mishima Cider."
Column「List of Morning Markets in Hachinohe」
|Morning Market in front of Mutsu-Minato Station
|In front of Mutsuminato Station
|All year round (Closed on Sundays, Second Saturday of the month, New Year holiday) 3:00AM to Noon
|No. of vendors
|Approximately 100
|Contact information
|Hachinohe Municipal Fish & Vegetable Retail Market
Kutsu no Miura (Miura Shoes)
|Tatehana Wharf Morning Market
|Tatehana Wharf
|March 13 to end of December
Every Sunday
Dawn to about 9:00AM
|No. of vendors
|Approximately 300
|Contact information
|Minato Sunday Morning Market Cooperative (Uemura)
|Hachinohe Newtown Morning Market
|Grand Sunpia
Hachinohe Parking Lot
|Early April to end of November
Every Saturday
5:00 to 7:00AM
|No. of vendors
|Approximately 30
|Contact information
|Hachinohe Newtown Morning Market Cooperative
|Machi & Oka no Asaichi (Machi & Oka Morning Market)
|Grand Sunpia
Hachinohe Parking Lot
|Every day (except for Saturdays) from early April to early December
Dawn to 7:00AM (weekdays)
Dawn to 7:30AM (Sundays and holidays)
|No. of vendors
|Approximately 30
|Contact information
|Machi & Oka no Asaichi-kai
|Minato-Yamate Street Morning Market
|Minato-Yamate Street
|Mid March to December Every Sunday 4:00 to 8:00AM
|No. of vendors
|Approximately 50
|Contact information
|Minato-Yamate Morning Market Cooperative
|Hachinohe Umineko Morning Market
|Rising Koyo Parking Lot
|All year round
Every Saturday
Dawn to 8:00AM
|No. of vendors
|Approximately 70
|Contact information
|Hachinohe Umineko Morning Market Cooperative
|Johgen-ji Temple Friday Morning Market
|Johgen-ji Temple parking lot
|March to December
Every Friday
Dawn to 8:00AM
|No. of vendors
|Approximately 10 to 15
|Contact information
|Hachinohe Umineko Morning Market Cooperative
|Hachinohe Station Morning Market
|In front of Hachinohe Station
|April to November
Every Sunday
4:00 to 6:30AM
|No. of vendors
|Contact information
|Hachinohe Station Morning Market Cooperative (Ogasawara)
|Miyagisan Sunday Morning Market
|Miyagisan Shrine
|April to November
Every Sunday
5:00 AM to 8:00AM
|No. of vendors
|Contact information
|Choja Morning Market
|Choja Matsuringu Park
|April to December
Every Saturday
4:30 to 8:00AM
|No. of vendors
|Contact information
|Hachinohe Morning Market Cooperative
|Hachinohe Afternoon Market
|Choja Matsuringu Park
|April to December
Every Friday and Saturday
2:00 to 5:00PM
|No. of vendors
|Contact information
|Hachinohe Afternoon Market Office
|Chojya Matsuringu Morning Market
|Choja Matsuringu Park
|March to end of November
Every Tuesday and Wednesday
Dawn to 8:00AM
|No. of vendors
|Approximately 10
|Contact information
|Hachinohe Morning Market Promotion Council/
Column「The Public Bath Culture of Hachinohe」
Aomori has one of the highest number of public bathhouses per capita in Japan. There are still over 30 public bathhouses (known as Sento) operating within the city of Hachinohe. People of Hachinohe are known for their love of public bathhouses, preferring them over their own bath at home. Some even keep their bathing essentials in their cars.
What makes public bathhouses in Hachinohe unique is the fact that they are open from very early in the morning. The likely reason for this is that public bathhouses in Hachinohe open early to serve fishermen who are coming back from the ocean in the morning. In Japan, it is rare for public bathhouses to be open early in the morning, and it has garnered much attention from the media.
After spending time at a morning market, why not go to a public bathhouse and start off your day feeling refreshed? That's how the Hachinohe locals do it!
Experience the early morning culture of Hachinohe with a convenient "Hachinohe Asaguru" plan!
"Hachinohe Asaguru" is available to hotel guests in Hachinohe, and allows you to tour morning markets and public bathhouses by taxi. Departing the hotel early in the morning, enjoy breakfast and shopping at a morning market and then relax by soaking in a bath at a public bathhouse. You will be back to your hotel while it is still morning. It is a very popular early-morning sight seeing excursion for those who have to work during the day.
For details on "Hachinohe Asaguru,"
please visit the website:http://www.hachinohe-cb.jp/asaguru/


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Module content
World mechanisation issues; Farm mechanisation development; Developments in farm machinery design and operation; Introduction to farm machinery management, including effective machinery selection and replacement, maximising field performance and managing machinery costs; Introduction to Health and Safety management, including an introduction to management responsibilities and risk assessments.
Module outcomes
To achieve credit for this module, students must be able to:
- Discuss the role and importance of machinery and mechanisation development for world agricultural systems.
- Research and present a review of machinery developments in a specific agricultural sector.
- Discuss the approaches to effective machinery planning, selection and management.
|2-page Technical Note assessing outcome 2
|In-class test (1 hour) assessing outcomes 1 and 3
Key texts
Students should be familiar with the content of at least one of the following:
- Hunt, D. (2008). Farm Power and Machinery Management. (10th edition). Waveland Press Inc.
- Landers, A. J. (2000). Farm Machinery: Selection, Investment and Management. Farming Press.
Supporting texts
- Banks, A. and Melves, S.F. (eds.) (2012) Horizons in crop production: precision agriculture and no-till farming. Nova Science.
- Davies, D.B., Eagle, D.J. and Finney, J.B. (2001). Resource Management: Soil. Farming Press.
- Health and Safety Executive (HSE). (2006). Essentials of Health and Safety at Work. (4th edition). HSE.
- Nix, J. (2014) Farm management pocketbook. 45th edn. Agro Business Consultants.
- Stafford, J.V. (ed.) (2015) Precision Agriculture '15. Wageningen Academic Publishers.
- Witney, B (1995) Choosing and using farm machines. Land Technology
- Zhang, Q. and Pierce, F.J. (eds). (2013). Agricultural Automation: Fundamentals and Practices. CRC Press


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+79636695693 Available funds to Invest in any profitable business Business1 year ago - Services - Florida City, FL, USA - 634 view
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I will appreciate if you can give us the best assistance that i need,hoping to cooperate with you in the nearest future i shall let you know the amount of funds that will be investing on your project via mail..Tel...etc.Interested individuals or corporate body should contact us for more information,waiting for your prompt reply as soon as possible...
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The Snow Sisters, Cinderella, the Frog Princess, the Beauty Princess, and Rapunzel will host a royal dinner in the Grand Ballroom with dance performances, musical performances, and Christmas magic.
Guests may meet and converse with many characters from favorite fairytale stories. Each child will receive a gift from the princesses of Gleam and Glow and be invited into a Christmas dance and sing-along. Photo opportunities are available.


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Folate biosynthesis is an essential bacterial pathway that is absent in higher animals, and it has been a target of antibacterial agents for over 70 years. Sulfa drugs inhibit the enzyme dihydropteroate synthase (DHPS) in the pathway by acting as non-productive substrate analogs of p-aminobenzoic acid (pABA). However, the flexible pABA binding site is structurally susceptible to resistance mutations, and the sulfa drugs are rapidly becoming therapeutically ineffective. In contrast, the binding site of the second DHPS substrate, pterin-pyrophosphate, is buried in a conserved pocket that is less likely to tolerate mutations. We propose to generate new classes of potent DHPS inhibitors that specifically engage this pocket. These inhibitors can potentially be developed into novel therapeutic agents that still target folate synthesis but which avoid the problems of resistance. To generate effective inhibitors of any enzyme, it is crucial to understand the structure and mechanism of its active site. This information is largely absent for DHPS, and understanding how DHPS performs catalysis at the molecular level will be a central goal of the proposal. Another goal will be to understand the molecular and functional basis of sulfa drug resistance to avoid this problem in our future drug designs. This comprehensive approach will require the joint expertise of the two principal investigators in structural biology, medicinal chemistry, biochemistry, computational biology and microbiology. The project will also incorporate the relatively new technique of fragment based drug discovery to identify novel small inhibitory chemical scaffolds that can readily be elaborated by chemical synthesis. Exciting new data described in the application provide strong support that the project can realize its ultimate goal which is to rapidly develop new antimicrobials that minimize the emergence of drug resistance. Although we aim to develop broad-spectrum anti-infective agents, our microbiological screening will focus on S. aureus and P. jirovecii that have emerged as particularly problematical infectious disease agents in the U.S. in recent years.
This proposal is aimed at structurally understanding and exploiting the enzyme target of the sulfonamide antibacterial agents, dihydropteroate synthase;to study enzyme mechanism, drug resistance and inhibitor design. It is expected that these studies will lead to new antimicrobial agents and a new understanding of target based sulfonamide resistance.
|Griffith, Elizabeth C; Wallace, Miranda J; Wu, Yinan et al. (2018) The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase. Front Microbiol 9:1369
|Zhao, Ying; Shadrick, William R; Wallace, Miranda J et al. (2016) Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents. Bioorg Med Chem Lett 26:3950-4
|Hammoudeh, Dalia I; Daté, Mihir; Yun, Mi-Kyung et al. (2014) Identification and characterization of an allosteric inhibitory site on dihydropteroate synthase. ACS Chem Biol 9:1294-302
|Yun, Mi-Kyung; Hoagland, Daniel; Kumar, Gyanendra et al. (2014) The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg Med Chem 22:2157-65
|Hammoudeh, Dalia I; Zhao, Ying; White, Stephen W et al. (2013) Replacing sulfa drugs with novel DHPS inhibitors. Future Med Chem 5:1331-40
|Zhao, Ying; Hammoudeh, Dalia; Yun, Mi-Kyung et al. (2012) Structure-based design of novel pyrimido[4,5-c]pyridazine derivatives as dihydropteroate synthase inhibitors with increased affinity. ChemMedChem 7:861-70
|Zhao, Ying; Hammoudeh, Dalia; Lin, Wenwei et al. (2011) Development of a pterin-based fluorescent probe for screening dihydropteroate synthase. Bioconjug Chem 22:2110-7
|Qi, Jianjun; Virga, Kristopher G; Das, Sourav et al. (2011) Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes. Bioorg Med Chem 19:1298-305
|Hevener, Kirk E; Yun, Mi-Kyung; Qi, Jianjun et al. (2010) Structural studies of pterin-based inhibitors of dihydropteroate synthase. J Med Chem 53:166-77
|Pemble 4th, Charles W; Mehta, Perdeep K; Mehra, Smriti et al. (2010) Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis. PLoS One 5:e14165
Showing the most recent 10 out of 13 publications


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FAQ: How Do I Search NCDs Using My TCI SuperCoder Subscription?
If your TCI SuperCoder subscription includes access to NCD (national coverage determination) search, you have a few options for finding these national Medicare policies once you're logged in:
Lab tip: Medicare provides CPT® to ICD-10-CM crosswalks for many lab codes. On TCI SuperCoder's code details pages for those lab codes (such as 87086), you'll find an NCD tab under Compliance Tools when you're logged in. Open the tab to see the crosswalk information and links to the relevant NCD.


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- Bass Guitars
- >
- Enore E20 7/8 size Bass Guitar
Enore E20 7/8 size Bass Guitar
per item
Encore E20 7/8 Size Bass Guitar
If a full, long scale bass guitar is just too much to manage, the superb new 7/8 size Encore E20 is the perfect answer. The E20 allows younger players and players with smaller hands to experience all the feel, sound and excitement of playing bass guitar – with none of the hassle!
The E20 is an original Encore® bass guitar created by Trev Wilkinson and the UK Encore design team.
Colour Sunburst Body 7/8 Size Solid Tonewood Scratchplate 3-ply White Frets 20 Neck Maple – Bolt-on Bridge Guitar Tech Fully Intonatable Machine Heads Guitar Tech Triangular Diecast Hardware Colour Chrome Pickups Guitar Tech Split Single Coil Controls 1 Tone, 1 Volume


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I meant to write about this report upon its release last week, but recent events have gotten in the way (and apparently the New York Times is a week late as well). In the article, Stiglitz states the over-arching problem as well as anyone could:
If you don't measure the right thing, you don't do the right thing.
Of course, the report is lacking in solutions, and if its authors have been paying attention to more heterodox fields like ecological economics, it doesn't really add much new.
The report is more critique than prescription. It elucidates in general terms why leaning exclusively on growth as an economic philosophy may yield unhappiness, and it suggests that the incomes of typical people should be weighed more heavily than the gross production of whole societies. But it sidesteps the thorny details of slapping a cost on a ton of pollution or a waylaid career, leaving a great mass of policy choices for others to resolve…
Indeed, the difficulty comes in turning these general principles into new means of measurement. The report notes that its authors concur on the big picture, but diverge on the methodologies to be employed when it comes to factoring in the value of a better education and cleaner skies.
My guess is that they would make much better headway if they would collaborate with those outside the mainstream, like Herman Daly, for instance, who have been thinking about these issues for decades.


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Rakhsa bandhan is celebrated by all Indians living in different countries and within different states in India. People living in countries like U.S , U.K and Australia where the ratio of Indians is increasing every year also witnesses Raksha Bandhan.
Also See : Raksha Bandhan SMS
Rakhsa Bandhan is a festival to celebrate the bond between a brother and a sister. Usually humans don't really express their feelings to their loved ones every day so like other occasions like friendship day and other this raksha bandhan is to strengthen and celbrate the lovely bond between a brother and sister.
Usually according to the rituals raksha bandhan is celebrated in the mornings according to the Hindu calender but it's not necessary to celebrate it at that time only. It can be celebrated according to our convenience.
Firstly all family members get together, all dressed up well. A pooja thali with a rakhi, diya(lamp), sweets is brought to greet the brother. Sister revolves the thali with diya in front of her brother's face. A tika is put on the forehead of brother by the sister and then rakhi is tied to brother's wrist. In turn brother gives a gift to sister and then both feed each other by sweets and wishing each happy raksha bandhan.
|Raksha Bandhan Pooja Thali
Also the sister wishes for the well being of the brother ad brother takes a vow of protecting his sister from difficulty in her life.
So now you have understood how raksha bandhan is celebrated. Wish you a very happy raksha bandhan.


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Frequently Asked Questions
Will the planning control areas and redevelopment areas have the same boundaries?
No. The planning control areas are smaller than the redevelopment areas as they are specifically intended to manage and control infrastructure works associated with the new stations.
The redevelopment area will take a broader scope to the planning, development and place-based outcomes for the train station precinct.Back
Still have a question?
Browse the rest of our website or contact us if you can't find what you're looking for.


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Cast iron teapot, black with raised pattern. Infuser basket included, holds approximately 20 ounces. Approximately 7.25 inches spout to back, would make a decorative piece when not in use. Gift package of 6 Earl Grey tea bags, 100% pure Ceylon Tea with natural flavoring from Coffee City USA. Something more than just a teapot; together they make a really nice gift.
Success! Feel free to
continue shopping
or head to your


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My Fireworks and Order
Your Fireworks will last a long while, Provided that they are kept cool and dry..
All fireworks purchased through our website, require you to pick up your order from our showroom. We do not offer a Next day delivery.
But an exception can be made for local orders that are over a certain amount. For more details, it is beneficial for you to ring 0121 733 3555 so we can further our discussion about your order.
Within the Peak, season orders are sorted the moment they are made, If you wish to amend or cancel an order, It is highly beneficial for you to call us on 0121 733 3555, and tell us your order reference, as soon as you can. This is so we can get your order ready to be picked up from our showroom in a timely manner.
If you have made an account, we update your member area with a status: this means it will show you if it is processing, on hold, or completed. if there are any problems with your order. We will ring you, But if you have placed an order and no status has been changed, we advise you to ring us. 0121 733 3555 or use our live chat, and tell us your order reference number so we can quickly deal with your enquiry.
If an item is missing from your order after you have checked out. Please contact our online chat or email. firstname.lastname@example.com, don't forget to include your order number, and we will look into it.
We do not offer a returns policy. If your item is faulty or damaged. after leaving the showroom, We require you to take a photograph and to call us directly on 0121 733 3555 Or by email at firstname.lastname@example.com. So we can look into this more effectively.
No consequential losses arising out of the use of any products will be accepted. Prices are subject to change without prior notification. and are correct at the time of going to press. The attributes are estimated from the manufacturers unless stated otherwise. When the Consumer Protection (Distance Selling) Regulations 2000 apply, Solihull Fireworks Ltd will accept cancellation of an order provided that the customer confirmed in writing to the address on this website within seven days of receipt of the goods. Upon receipt of such cancellation, Solihull Fireworks will notify the customer of the procedure.
A charge may be made to the customer equal to the cost of collection and return to Solihull Fireworks Ltd
We Protect!/Need Help?
We value everyone privacy. Please view our Privacy Policy for complete details on how we use the information we collect.
Fireworks Frenzy is protected with SSL (secure socket layer) encryption, the highest standard in Internet security.
We are a big believer by help every single customer where possible. Here are our ways for you to contact us over fireworks.
Our Live Chat – When we are around we will be online look out for a purple tab bottom right of your screen called "Chat with us".
You can ring us on 0121 733 3555.
You can even email us at firstname.lastname@example.com.
or you can visit our showroom.
Fireworks Frenzy
Solihull Fireworks Ltd
353, Haslucks Green Road,
Shirley, Solihull, West Midlands
Yes, we do. Our main company Solihull Fireworks, Is West Midlands best display company for providing an excellent service for wedding fireworks and Bonfire Night Displays. We go the extra length so you can have the magical worry-free evening you always wanted. We have many packages for you to browse through.
We always have good offers for people who wish to save some money. Our Special Offer category is full of all kinds of on sale items. It categories items from our "Display Packs" to "Rockets". You will always find, good savings in our showroom or online.
We aim to list 75% Of firework we sell in the shop online. We have a huge variety for you to choose from. This is why we always encourage our customers to visit our showroom and as well as online.
Most offers or discounts you see in our showroom are online. and the same with online offers can be found in our shop. We will always show what brand we sell online. So if you don't see a firework that specific brand has, Contact Us and we will see if we sell that type of firework. (If not we will add it to future orders.)
Creating My Aaccount
An easy way of doing this is by the following methods.
1) Click the "My Account" link at the top right side of our site.
2) Enter your email address and password.
3) Press register
Then simply follow the setup wizard to complete setting up your account. Your information is NEVER sold to any other company and is kept completely private to us only. Please view our Privacy Policy for more information
A simple Method is to Click the "My Account" link at the top right-hand side of our site to edit your account information. We encourage our customers to keep all relevant information such as phone numbers, email address, and home address, upto update.
Don't worry it happens to us all. Click the "My Account" link at the top right-hand side of our site. Under the login box, you'll see a link that says "Lost your password?". That link will send an email to you with your password.
Extra Information
There are Four categories fireworks fall under, the hazard, NEC (net explosive content) Noise Level.
Category 1 or F1 Fireworks.
These can be used indoors, and more commonly known as indoor fireworks.
Category 2 or F2 Fireworks.
Common F2 fireworks are for outdoor only (Unless stated otherwise). These are commonly known as garden fireworks and can have a minimum safety distance of 8 metres, and spectators between 8 and 20 metres.
Category 3 or F3 Fireworks.
F3 Fireworks are very known as display fireworks as most hold effect of these criteria. They usually have a minimum safety distance of 15 metres for operators and 25 metres for spectators.
Category 4 or F4 Fireworks.
F4 fireworks are not available to members of the public and are for use by persons with specialist knowledge, who more then likely has BPA Training for handling storing and other categories. and who work for a Professional Company.
Fireworks Frenzy, Only sell F1 – F2 – F3 Fireworks. If you wish to have an F4 Event please visit our main company Solihullfireworks.co.uk.
We do offer a Discount for loyal customers, using a coupon code. We have teamed up with Seasonal Traditions. More details can be found on the forum.
Easy as eating pie. After adding items to your cart, click the "View Cart" link at the top of this site to view your cart. At the bottom of the shopping cart, you'll see a box where you may enter your coupon code. Click apply, and wait for the cart to update.


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Caos Calmo bed and breakfast
|A stylish and refined bed and breakfast in Rome by Tiburtina Station
Caos Calmo bed and breakfast: Location features
Location: Rome, Lazio
Part of the following areas:
Location: Urban
Caos Calmo bed and breakfast: features linked to the quality / rate ratio
Type: Bed and Breakfast
Italia Lodging ® internal classification: 4 Moons
Caos Calmo bed and breakfast is also classified as: No Label
Official category: not available for this type of accommodation
Average rate for 2 persons per night: 60 - 100 € [see detailed rate table]
Standard: charming accommodation
Total number of apartments / rooms: 4
Caos Calmo bed and breakfast: Accommodation facilities
Caos Calmo bed and breakfast: kind of accommodation offered:
Caos Calmo bed and breakfast: Reservation policies
Booking Caos Calmo bed and breakfast through Italia Lodging is free of charge. Italia Lodging is not going to charge you any commission for its services. The reservation can be confirmed once you have made a request and received an availability notice directly from the hotel. In order to definitively confirm the reservation the hotel can request a deposit (according to the period requested, the number of nights etc.) which can be paid by credit card or bank money transfer, The total amount of the deposit will be notified before the definitive booking confirmation procedure. Italia Lodging guarantees on behalf of the hotel the highest security level during the transmission of your data encrypting the transactions through secure server with extended validation certified by Verisign. Any amendment or cancellation must be notified by e-mail/fax directly to the hotel. Deposits paid are not refundable. We would also like to inform you that using the Italia Lodging on-line reservation system you are dealing with the accommodation provider directly and that the Italia Lodging task is to make your reservation procedure easier and safer.
Caos Calmo bed and breakfast: Cancellation policy and penalties
From reservation to 20 days before arrival -> cancellation fee 40%
From 19 days before arrival to 8 days before arrival -> cancellation fee 65%
From 7 days before arrival to day of departure -> cancellation fee 100%


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Websites of Interest About Madagascar
The Embassy of Madagascar, Washington D.C., U.S.A. --- The official website, with loads of information and links to further sites they recommend.
Madagascar News --- The latest news, in English.
Mad Facts --- A concise list of data about the country from Wikipedia.com.
Madagascar Travel Guide Book --- The best travel guide to Madagascar, in my opinion, is the one authored by Hilary Bradt. Click this link to see / order the current volume.
Destination Madagascar --- The Lonely Planet's introduction to culture, history, facts, travel reports, and lots of other information and tips about traveling in Madagascar.
The Living Edens --- A great assortment of natural history information, field experiences, and interesting facts about Madagascar.
A Lemur's Tale --- The bittersweet P.B.S. story of baby ring-tailed lemurs, including an unusual white infant named 'Sapphire' at Berenty Reserve in the southeast.
Missouri Botanical Garden --- Lots of information on Malagasy plants, including many photographs; choose 'Africa' on the left-hand side of their site and proceed from there.
/ PBS Online Adventure to the Wilds of Madagascar
--- Follow Peter Tyson's dispatches from the field at several
fantastically wild places that he visited in May-June 2000.
Current Weather Report --- What's the weather like right now in Antananarivo ? Provided by Yahoo.
Greatest Places Online --- This site has a bunch of fun and educational displays and links about Madagascar - learn about giant hissing cockroaches, watch a chameleon catch live food, etc. The kids will especially like this one.
Royal Botanic Gardens Kew --- An in-depth scientific look at vegetation and geology mapping and changes in Madagascar.
Classic Books For Sale About Madagascar --- Rupert Parker's site offers many old and out-of-print books about Madagascar that aren't easy to find elsewhere.
Dinofish.com --- An updated compendium of facts, research, etc. about the coelacanth, a prehistoric fish surviving in the Mozambique Channel near Madagascar and the Comores Islands.
ADCHAM.com --- This site is an international center for the sharing of advanced chameleon information regarding all aspects of old world chameleons.
Images From A Fragile Planet --- Greg & Mary Beth Dimijian's admiration of Earth's beauty is evident in their nature imagery from around the world. Their newest section, taken on tour with me during Oct-Nov 2003, features Madagascar.
INDRI CALL >>> Click this LINK to reach a sub-page of the above site to hear the whale-like call of the indri.
The Lost Luggage Tales --- All kinds of great travel info, reviews, advice, travel tales, and oodles of handy links to other resource sites helpful to world travelers.
RETURN TO HOME : www.bluechameleon.org
www.ReptileRally.com (< Florida 1-Day Reptile Adventures) www.CornUtopia.com www.BillLovePhotography.com


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I thought I would also post a few more right here. These may not necessarily be "monsters," but they are hardly "miniatures" either. These will hopefully appeal to the gear heads out there, including those of you who are into running shorts. I am seeing more and more of you guys all the time, which is cool!
Why or why did shorts stop being "short?" At some point, they became "long," which is wrong on so many, many levels.
Here are a couple for the footballers out there, American football that is. Not to be confused with soccer, which is completely different and has much less equipment.
No wonder these guys are always getting hard ons during matches. Who wouldn't? Nothing shows off a bulge – or, for that matter, one's entire tight body – like wrestling gear.
Well, see through whities do a pretty good job of showing off bulges, come to think of it.
This last photo is one of the 5 new additions to "Monster Bulges," so I sort of cheated and snuck in a "Monster" one on you. I know, you're furious. The previous photos – and more great ones just like them – can be viewed at Bonehard and Bulgeology. Both of these sites are Tumblr blogs with some of the most amazing professional and amateur photographs you will see anywhere online.


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I've been so busy, painting and making digital art, I wanted to share this Free Fall Printable and the New ClipArt in my Etsy Shop. To get the Free Fall Printable click here or on the photo above. If you go see my Etsy Shop you see all of the New ClipArt I created using the Pumpkin Patterns.
The fall printable as shown above is 8 x 10 so you can print and frame. You can also get a blank one below.
This wreath printable has no text or background color so you can add whatever you please. It's an 8 x 10 so you can easily frame it.
Here's one of the wreaths in my Pine Collection ClipArt at Etsy.
And another in my Holly Collection ClipArt. I used "Joy" not only for Christmas but also for one of my bffs who's name is Joy. We get together every week and paint. She started as a paint student 20 – OMG, twenty??? – yep, 20 years ago. Now we just paint together and catch up.
I have to ask you – what do you think of the grey backgrounds? I'm not 100% sold on them. I prefer white. Of course, customers can choose their own text and colors but for an example, what color would you choose to highlight the wreath clipart?


text: Emdat, Inc. is a leading supplier of web-based medical documentation solutions. Empowering over 20,000 clinicians globally, Emdat continues its single focus to create sophisticated technology designed to decrease cost and maximize productivity and accuracy of the document creation process while protecting the richness of the clinical narrative. Emdat's mobile app allows clinicians to generate documentation from anywhere with a Wi-Fi network or cellular data connection.


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Offered by Galerie de Lardemelle
Paintings & drawings - XIXth century
Frédéric REGAMEY (Paris, 1849 – Paris, 1925)
The studio of the painter Jules MACHARD in 1887
Signed and dated '1887' lower right
32 x 24 cm
Exhibition: In 1888, Salon of Paris under the number 3526
Our drawing is one of the nine pastel studies that Regamey exhibited at the Salon of 1888 under the same No. 3526, and which served to book illustration "Painters of Woman" (also published in 1888) by Claude Vento (pseudonym of Alice de Laincel Vento, 1853-1924, chatelaine of Suze, collector and writer who enjoyed some success).
In addition to the Machard, the other eight studio of painters represented were those of Joseph Wencker, Carolus-Duran, Charles Chaplin, Alexandre Cabanel, Jean-Jacques Henner, Gaston Saint-Pierre, Jules Lefebvre and Leon Bonnat.
The drawings were exhibited in the same frame as indicated by the comment of François Bournand (Director of the Salon of Paris and editor in chief of "Black and White) in the" Feu Follet "which calls" very interesting and admired frame of Mr. Regamey containing studio views of nine painters ".
The Jurassian Jules-Louis Machard (1839 Sampans – 1900 Meudon), pupil of the religious and historic painter Emile Signol (1804 to 1892) and academist Ernest Hebert (1817-1908), was winner of Rome Prize in 1865 with Orpheus goes to Hades, and lived in Rome from 1866 to 1874. Sensible representative of academicism, Machard was particularly renowned for his portraits of women (he would have made more than 300 portraits during his career), his naked or allegorical and mythological scenes, while painting rare religious subjects (such as those that ordered the Marquis of Chennevières then Director of Fine Arts).
Machard is faithfully represented in the Regamey pastel as the arrangement of his studio, such as it can be seen on black and white photographies of the studio of Edmond Bernard and Adolphe Giraudon, dating from the same era.
We recognize in particular the large-inspired chandelier rock, drapes lining the back wall. The paintings hanging on the same wall are arranged identically. Before the hanging wall, placed on a Louis XIII style cabinet, identifying a portrait of a player of mandolin, recently spent in public sale, which is hung on the opposite wall of the studio on another photography. There is also a naked woman from behind with a child. The painting on the far right, the second from the top, could be that of a Girl with red fur in the Musée de Dole. The Regamey pastel also tells us about the colours of the Persian carpet, probably a Senneh kilim near the bed on which Machard sits and which, on one of the pictures, is under the piano stool on which the woman of the artist (Ernestine Aleo, from Cuba, married in 1875) sits.
Of Swiss origin, the youngest of his painter brothers William (1837-1875) and Felix (1844-1907), Frederic Regamey was primarily a designer and illustrator who specialized in depictions of the social life of his time, sports venues including fencing, a discipline in which he excelled itself. Nevertheless he realized also paintings on French contemporary history. From 1898, Regamey lived mainly in Alsace, the region of origin of his wife Jeanne, and he devoted himself to the works of regionalist thematic illustration.
In 1888, Frederic Regamey was domiciled in Paris at 35, rue Rousselet in the current 7th district.
Museums: Louvre, Orsay, Versailles, Strasbourg, Colmar…
Price : on request


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Health Care Equality Important
Reviewing public health in this province is an important task, and one that rightly includes the active participation of all Islanders. Nothing is more important than the health of our families and communities. The 2016 Chief Health Officer's report examines the key causes of poor health in Prince Edward Island. The report asserts that the prevalence of chronic disease in PEI is linked with behavioural risk factors such as: poor diet, a lack of exercise, and addictions. While everyone is susceptible to these risk factors, those with lower incomes are more vulnerable, and as a result, experience poorer health outcomes.
One way to deal with the "health inequity" is to deal with income and wealth inequities in our society. Disparity is driving high cost health care items like emergency health care, addiction, and untreated mental health issues in our communities. If we were to deal with these inequities at the front end, by reducing poverty and raising incomes, we could reduce the rising costs of dealing with them when they show up in the health care or justice systems later on. The province's introduction of a toolkit for family doctors to assist patients who are experiencing poverty is a good idea also. The more resources and services that family doctors are aware of that can help their patients the better.
Let's also remember the importance of upholding health care equality. This principle means that access to public health care needs to be equal and free for all Canadians. Without this equality, many people in our society would not receive proper health care and our standard of living would decline. In fact, public services in general provide a quality of life advantage for all Islanders. They are the most affordable way of meeting our needs and are accessible to everyone, including those with lower incomes.
Karen Jackson,
President, UPSE


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Even though zero per cent is lower, consumers are likely to be lured towards the one per cent interest rate option, according to new research from Dr Mauricio Palmeira from the Department of Marketing at Monash University in an upcoming paper in The Journal of Consumer Research .
In the study, consumers were faced with a choice between a credit card with a zero per cent interest rate and one with low annual fee, 49 per cent of survey participants chose the low interest rate credit card.
This number jumped to 73 per cent when the interest rate was one per cent instead of zero per cent.
Dr Palmeira said that when businesses offer zero per cent, consumers get confused and avoid the offer.
Dr Palmeira cites the "principle of diminishing sensitivity" as a key reason for this behaviour. This theory makes the perceived difference between two quantities decrease as both increase by the same amount. For example, the difference between ten and 20 is perceived as larger than the difference between 110 and 120.
"Zero is a special value that prevents consumers from using relative comparisons when making decisions," said Dr Palmeira.
"Zero makes us lose our reference point when we compare it to other values. Next to zero, any number seems larger, so relative comparisons are thrown out the door,"
"If a consumer is offered a credit card with a 25 per cent interest rate, and then offered a credit card with a one per cent interest rate, the gap between the two interest rates appear to be substantial,"
"On the other hand, if a consumer is offered a credit card with a 25 per cent interest rate and another interest rate of zero per cent, the zero can make consumers lose their bearings when it comes to determining the gap between the two," said Dr Palmeira.
For more information contact Megan Gidley, Media and Communications + 61 3 9903 4843 or 0448 574 148 or Dr Mauricio Palmeira + 61 3 9903 1592 or 0425 380 478.


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GoPro Handlebar/Seatpost Pole Mount
- 85323000064
- Brand
- Go Pro
- Availability:
- In Stock
Customers Also Viewed
GoPro's Handlebar/Seatpost Pole Mount is a tube clamp for mounting your Hero2, Hero3 and original HDHERO camera onto your bike's seatpost or handlebar tube. Capture all the action while you ride from this on-bike mounting accessory. Instead of capturing the same helmet shot that everyone else gets, this lower point of view provides intense video that will impress you and your friends. The clamp also attaches to chainstays or or any other place on the bike that is in the clamp's range of 0.75-1.4". The clamp will clamp to virtually any pole that is within it's range, such as boom poles, small diameter pipes, windsurfing and kitesurfing control bars. The included orientation adjusting mount provide numerous position options.
• Mounts your Helmet or Motorsports HERO camera to your seatpost or handlebar tube for a unique perspective!
• Fits on tubes or other parts ranging from 0.75-1.4" in diameter
0 Reviews
Additional Information
YES! We are a Go Pro Authroized dealer!
All new products come with a full manufactures USA Limited warranty.
Protect your purchase with an optional 3-5year extended warranty.
Manufacturers' warranties don't cover everything. Protect your valuable investment with an Accidental Damage Warranty.
Choose the warranty that's best for your purchase and customize it to your needs. Products covered: Digital Cameras, Lenses, Video Cameras, Flashes and Lighting
Total Protection from:
+ Manufacturer Defects
+ Impact Damage
+ Sand/Grit Damage
+ Accidental and Unintentional Abuse
+ Mechanical Malfunctions
+ Normal & Abnormal Wear & Tear
Protection plans include standard coverage as well coverage for malfunctions due to accidental damage from handling (ADH). This includes malfunctions due to liquid damage that were the result of an accident. Call us today, if you have further questions.
Please note, this service contract must be purchased/registered within 30 days from the date the equipment is purchased. Once purchased, you will recieve an email with instruction on how to register your warranty.
Learn More
Attention California Residents: This product may contain chemicals including but not limited to, lead and/or nickel, that can cause Cancer and other Reproductive Harm.
For more information, please visit www.p65warnings.ca.gov.


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Just over a month after Avicii's unexpected passing, his family has announced funeral arrangements for the late DJ/producer. The 28-year-old, born as Tim Bergling, will be remembered in a private affair with those closest to him.
In a statement to Billboard, Avicii's family wrote:
"There have been many inquiries regarding the funeral arrangements for Tim Bergling, known by music fans as Avicii. The Bergling family has now confirmed that the funeral will be private, in the presence of the people who were closest to Tim. They kindly ask media to respect this. There is no additional information forthcoming."
On April 20, 2018, the EDM community was shook to its core when Avicii's body was found in his hotel room in Oman. Authorities have since ruled out foul play. An autopsy report has yet to be revealed, although a previous statement from his family implied suicide.
That statement read:
"Our beloved Tim was a seeker, a fragile artistic soul searching for answers to existential questions. An over-achieving perfectionist who traveled and worked hard at a pace that led to extreme stress. When he stopped touring, he wanted to find a balance in life to be happy and be able to do what he loved most – music. He really struggled with thoughts about Meaning, Life, Happiness. He could not go on any longer…"
As always, Avicii's family is asking their privacy be respected in this especially difficult time.
Fans will get to hear a new Avicii album with his family's blessing, according to Swedish magazine Aftonbladet. Details on that here.
RIP, legend.


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You are getting married! This will be one of the most treasured days of your life. However, you might not have remembered the most significant part of this magical day. Your wedding vows – Do you know what you will say to your future spouse? The wedding vows are the single most important part of your future union as husband and wife. What you promise to each other is more important than anything else you will do on this big day. This is a forever commitment and must not be taken lightly, but rather with special, well thought out consideration.
Wedding vows examples
Wedding Vow : Trust in You Completely
(Name), with all my love, I take you to be my wife/husband. I will love you through good and the bad, through joy and the sorrow. I will try to be understanding, and to trust in you completely. Together we will face all of life's experiences and share one another's dreams and goals. I promise I will be your equal partner in a loving, honest relationship, for as long as we both shall live.
Wedding Vow : Share in Your Dreams
(Name), from this day forward I promise you these things. I will laugh with you in times of joy and comfort you in times of sorrow. I will share in your dreams, and support you as you strive to achieve your goals. I will listen to you with compassion and understanding, and speak to you with encouragement. I will remain faithful to our vows for better or for worse, in times of sickness and health. You are my best friend and I will love and respect you always
Wedding Vow : Best Friend
(Name), today I take you to be my (husband/wife). Together we will create a home, becoming a part of one another. I vow to help create a life that we can cherish, inspiring your love for me and mine for you. I vow to be honest, caring and truthful, to love you as you are and not as I want you to be, and to grow old by your side as your love and best friend.
Wedding Vow : My One True Love
I (name), take you (name) to be my (husband/wife), my partner in life and my one true love. I will cherish our union and love you more each day than I did the day before. I will trust you and respect you, laugh with you and cry with you, loving you faithfully through good times and bad, regardless of the obstacles we may face together. I give you my hand, my heart, and my love, from this day forward for as long as we both shall live.
Wedding Vow : Love You Without Reservation
(Name), today I take you for my (wife/husband). I promise to love you without reservation, comfort you in times of distress, encourage you to achieve all of your goals, laugh with you and cry with you, grow with you in mind, and spirit, always be open and honest with you, and cherish you for as long as we both shall live.
Wedding Vow : The Best Person I Can Be
(Name), from the moment I first saw you, I knew you were the one with whom I wanted to share my life. Your beauty, heart, and mind inspire me to be the best person I can be. I promise to love you for eternity, respecting you, honoring you, being faithful to you, and sharing my life with you.
Photography: greergphotography.com


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Why Would I Want To Know This?
This guide is inspired by a reader question as well as a recent discussion I had about why I use the application Alfred. The question came to me as "I am using Spotlight to find files and while it will let me open them, I can't figure out where they are or how to actually get to the file on my computer. Can you help?"
I got to work answering this question and once I had a solution, I realized that this would be a great example of how much easier this process is using Alfred and a great example of why I use it. I thought I would show you step by step how this works in each program so you can see the difference.
In this example, I'll pretend I have a text file where I keep snippets of code that I need to reference or reuse and somehow I accidentally moved it. Now I need to find it and move it back to its desired location.
We'll start with Spotlight.
Search for the file in Spotlight
- Spotlight can be accessed by clicking on the magnifiying glass at the top right of your screen or the default key shortcut is command – space.
- Type in the information you are using to locate the file. I know in this case that it starts with sql but I don't know the full name. As I type the characters the results will change in real time to show me the results. Pretty cool.
- Okay – there is my file sql-snippets.txt, I see it right there at the top of the results under documents.
I can preview or open the file from Spotlight.
Hovering over the file name will preview it on the left – this is handy to be sure I have found the right file. Clicking on the file name will open the file in my default text editor. But how do I actually find this file on my computer?
Let's click on Show All in Finder.
Find The File in Finder
The Show All in Finder option does just what it says it will do. It shows you a view of all the files that it has located and displays them in a finder window. There are a lot of potential matches. I guess I could sort through all of these to find my file.
Maybe I can tweak my search criteria to limit the files it will show.
Another option is to use the built in search tools in Finder to narrow down the results.
- Click the + button which exposes a line to add additonal criteria.
- I know the file is a text document so I select kind is text and plain text. Click the + button again and add additional criteria – I know the file is called sql- something or other so I want to show files with a name that contains that information.
- Yes – this is much better. There is my file! Now where is it really located?
Locate the actual file location
- If you've already followed my guide on How To Customize Your Finder, you can see the file path in the bar at the bottom of your finder.
- If not, you can right click on the file and choose the Get Info option.
- This will bring up the inspector and the file path is shown in the Where location.
From here you can drag the file to a location in your Sidebar or on to your Desktop or copy and paste it to a different location.
Now lets find our file with Alfred
- Open an Alfred window using your defined key combination – the default is option – space
- We're going to use the Reveal command as we want to have the file presented in Finder rather than opening. I begin to type find and press return to access the top item in the presented choices.
Search by file name
- Once the find command is entered I begin to type the name of the file I am looking for, remember I know it starts with sql-
- Because Alfred is searching just by file name the results are much more manageable (there is a different command to search within files if that is the desired option)
- I see my file in the results so I just press the corresponding command to reveal my file, in this case it is return
As soon as I hit Enter I get a Finder Window that is opened in the location of my file, in this case it is in my Documents folder, and the file is highlighted so I can spot it easily. Now I am free to move it to its new location.
While Spotlight can be a wonderful tool for finding information on your Mac, it can also be somewhat overwhelming in the data it returns, even the way it is organized by type. I also find the lack of an easy way to select items from within the results without selecting with the mouse or arrow keys to be annoying with a large pool of results. What is a somewhat cumbersome (and rather unintuitive) process in Spotlight is managed in just a few keystrokes in Alfred, all without taking your hands from the keyboard.
Alfred is a free program although I highly recommend purchasing the additional Powerpack as it adds a tremendous amount of power and flexibility.


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This Kinetic Expression transform evaluates an expression on each kinetic point on each well resulting in a new kinetic plot.
The X values in the resulting plot are equal to the input matrix.
Use pointy to refer to the Y value of the kinetic point and use pointx to refer to the X value of the kinetic point. For example, the expression:
will result in a plot where each Y point is 100 times the input matrix.
This transform is contained in a transform module available for download from here.
There is currently no automated installation procedure for this module, however follow these steps to install the new module on an installation of WorkOut 2.5 R1.
1. Ensure all WorkOut windows are closed. 2. In Windows navigate to the installation folder, typically C:\Program Files\Dazdaq\WorkOut 2.5 3. Rename the file K3Trans.dll to K3Trans.bak 4. Unzip the ZIP file to the C:\Program Files\Dazdaq\WorkOut 2.5 folder. 5. From Start | Run type in the following: regsvr32 "C:\Program Files\Dazdaq\WorkOut 2.5\K3Trans.dll" Please note, if running under Vista and UAC is switched on (which is the default) then the regsvr32 operation will not be allowed. In this case from Vista Start type cmd; press Ctrl+Shift+Enter (instead of just pressing enter); and then press Alt+C to confirm the elevation prompt. Now type: regsvr32 "C:\Program Files\Dazdaq\WorkOut 2.5\K3Trans.dll" And press enter. 6. Press OK to confirm. 7. Launch WorkOut The Kinetic Expression transform will now be available to add to assays with kinetic data.


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Impressions from the Anthem Demo
The Team takes the upcoming Anthem for a spin and I gather my thoughts and share what the experience was like. Here's Anthem Demo Impressions.
This was an unbelievable mixed bag of love and hate that has me a bit worried about the release of Anthem. The team got together and had numerous sessions with the game during its Public Demo that kicked off Friday, 1st February. Of cause bare in mind that the Anthem Demo is not a complete retail product. That being said, the time left for the game to come out is troubling. So lets just into what I think of the game so far.
Bioware has succeeded at creating a brilliant Ironman game they didn't know they were building. Seriously, the feeling of having a powerful armoured suit that flies through the air like Ironman is unlike anything I've experienced before. And that's including the official Ironman games. Those were aweful. But there's more to it than that. There's a bit of Mass Effect Andromeda DNA in its gunplay. Which was about the best thing about that storied title. It feels good, not great, but good enough.
I also, absolutely love the game world that these Javelins (the armoured suits) and freelancers (the pilots) occupy. There's potential in the story but I feel like I haven't quite seen enough to let me know if I will enjoy it or not. It doesn't quite feel like the epic Bioware storytelling we've come to love. But an empty hollow version of it. And this has me worried. But there's more that has me worried.
Graphically its really breathtaking. Not quite the step into the Next-Gen of gaming we were shown at E3 but more than good enough by today's standards. However, its a buggy mess. Enemy units just disappear completely from the game world mid battle. In some cases, they just wouldn't stop spawning in droves. Don't get me started on the number of times I got kicked to title screen while trying to join a session with SkyGamers team mates. It became quite infuriating by the end of the Demo.
But the most annoying, hateful, potentially deal breaking thing from the game. Is all…those…loading screens. Seriously, some loading screens are infinite (bug obviously, but still annoying). Some just but their ugly heads while you are flying around and it completely breaks the flow of the game. My goodness they will feel like they go on forever, goodness forbid you get kicked to Title screen and have to watch the longest of the loading screens while you wait to dive back in. It's terrible. Bioware, please take notes from Rockstar on how to do Massive Open Worlds without loading screens. It's unforgivable in 2019.
Which leads me all to this. I'm getting the feeling that Anthem is not ready for Prime Time. Perhaps a push to December release would've given the devs to iron out all of these issues. But that won't happen, its far too late for that. It's a fun game no doubt, but I feel it needs more polish. I'll reserve full judgement for the retail release. Until then, proceed with caution. And Check out our awesome gameplay video below.


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One of the many reasons I redesigned and renamed this blog was to allow for guest posts. I want to allow for guest posts in order to expose my readers to other voices, to encourage those without a blog to start blogging themselves, and create synergies with more experienced bloggers.
I'm not going to be overly-draconian, but readers of this blog are used to reading about the following here:
- Education
- Technology
- Productivity
- Digital/New Literacies
- Leadership
- Design
Sticking, however loosely, to one of these topics is more likely to get your guest post accepted. I'm not interested in 'sponsored posts' (at the moment) but thanks for your interest.
- The post should not appear anywhere else (a brief 'teaser' on your blog is fine)
- Keep it reasonably short. No one reads epic blog posts.
- 9 Ways Become an Exceptional Guest Poster by Darren Rowse has some good advice.
- There's a large probability I'll change a few words around and alter punctuation to keep it in line with house style. I'll get in touch if any big changes are needed.
- I'll add a short introduction or conclusion to your post to introduce you and provide context. It will be obvious to readers that these are mine and not yours.
It's great that you want to guest post here. I appreciate the time it takes to write such things, however short. However, I must stress that the fact that you have written and submitted a post it to me does not obligate me to publish it.
If I decide against publishing your post I'll explain why. I tend to be brief by email, so don't think I'm being curt! 🙂
If your post meets the above guidelines:
- Please email it to me for consideration. I will respond with a "yes" or "no" ASAP.
- Please include your name (obviously!), your blog URL if you have one, Twitter username, etc.
Please put your post in the body of the email rather than as an attachment.
(adapted from Michael Hyatt's guest post policy)


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Gifted/FLAME/GATE Whatever you chose to call it - these are some special kids! They are the ones that question a little deeper, feel a little stronger and understand a little faster. In my classroom we strive to challenge these students to the fullest extent. Logic puzzles, upper level math, creativity, artistic talents, athletic skills, etc. Something new every single class for every single student. They may think they can't do it but I want to show them they can!
Degrees and Certifications:
Mrs. Villella
Hi! My name is MaryLei Villella. Ususally the first thing that I need to explain to my students and parents is how to pronounce my last name! The easiest way I have found to do this is to explain that if you say Vanilla, you can say Villella ("Va-lel-la").
I have been teaching for 5 years. I have only ever taught Gifted students for that entire time and can't see myself teaching anything else!
I worked for three years to receive my Gifted Endorsement, while teaching Gifted and growing my family.
I have been married for as long as I have been teaching and have three beautiful daughters. Adaline and Evelynn are 2 (twins) and my youngest is Isablle who is 10 Months. I understand what it means to be a busy parent!
I love my quirky, smart, quick witted, Gifted students who I feel understand me as well as I understand them. I look forward to challenging and motivating each and every one of my students to find their unique strengths.


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What's next for Jimmy Choo after the Michael Kors acquisition?
As the high-end handbag brand joins forces with the iconic shoe designers, Landor APAC's Nick Foley examines the best way to maximise brand synergy and identity
There's been a significant buzz in financial circles, recently, following the takeover of Jimmy Choo by Michael Kors. It is understood the North American retailer paid out US$1.2 billion to acquire the luxury shoe brand once renowned for its cameo appearances in HBO's iconic series Sex and The City.
Given the stagnant performance of Michael Kors in recent years, seeking growth through acquisition is not an unusual approach. From a branding perspective, the key question is whether the fit between Michael Kors and Jimmy Choo is right?
With JAB Holdings having now divested the Jimmy Choo brand from its portfolio, its new custodians will quickly need to determine what type of brand architecture will yield the greatest return on Michael Kors' investment? In its simplest form, the decision is whether to pursue a multi-brand or monolithic brand strategy? Sound complicated? It's not.
Monolithic or multi-brand?
In this day and age of start-ups, mergers and acquisitions, marketers are increasingly tasked with managing a variety of different brands and offers. If a company focuses on one single brand, then this is known as a monolithic brand strategy. Think Johnnie Walker or BMW. Effectively, one brand stretching across a number of different segments. When a company opts to have a variety of brands in similar segments and categories, this is known as a multi-brand strategy. General Motors exemplifies such an approach, managing multiple brands including Chevrolet, Vauxhall, Pontiac, Holden, Hummer and Cadillac.
When contemplating what the new owners of the high-end, luxury shoe brand will do, the actions of previous owners should be top of mind. It may come as a surprise to some of Jimmy Choo's patrons that the couture shoe designer exited the company quite a while ago – 2001, to be precise. Since then, the Jimmy Choo brand has had a few owners. Anecdotally, it seems that many of Jimmy Choo's well-heeled patrons are not aware he ceded direct involvement with the fashion icon back in 2001. This suggests subsequent owners have successfully deployed a 'multi-brand' strategy resulting in the brand's perceived independence.
The option to endorse
What makes the Michael Kors deal so interesting is whether the temptation of 'endorsement' will prove too great for the brand's new owners? When such an approach is activated, a brand's owner is seeking to maximise the synergy between two relatively disparate brands. Traditionally, endorsement has occurred when the parent company has made its name visible on a brand that previously existed independently. Think Kellogg's Special K or Mercedes Maybach.
How Michael Kors may choose to endorse, or co-exist, with Jimmy Choo is no doubt a key topic of discussion within the company's headquarters at West 42nd Street, New York. With a deal such as this, a high-end brand like Jimmy Choo is unlikely to benefit from endorsement courtesy of a more mainstream brand like Michael Kors. The focus, then, is likely to be how the venerable Jimmy Choo brand may stretch across some of the products currently within the Michael Kors stable of offerings.
Let the brand be
An Australian bushman, who went from swagman to millionaire by creating a bespoke, high end range of riding boots might act as a useful analogy to the marketing team at Michael Kors when considering how Jimmy Choo could best be managed. Reginald Murray Williams, better known as 'R.M', started a leather saddlery business in South Australia back in 1935. As time evolved it became apparent that the cobbler from the bush had a real knack for crafting high quality, handmade, leather riding boots. R.M sold his business in 1988 and it has been passed through a couple of different owners. In April 2013, 49.9 per cent of the business was sold to L Capital, the private equity arm of LVMH.
No doubt, the marketers at L Capital have been tempted to use the RM Williams brand as a portal for its other brands and products. Instead, the brand has been left alone and its distinctly independent DNA remains. So far this approach seems to be working, with the premium price tag on RM Williams branded goods still intact.
Resisting cost rationalisation
Aside from brand integration options, the finance department at Michael Kors could well be excused for looking at its latest acquisition and wondering where 'savings' could be made through manufacturing and back-of-house synergies. This could be risky. Between 1990 and 2008, the Ford motor company learnt a difficult lesson when it acquired the British luxury marque, Jaguar.
While Ford's marketing team never sought to incorporate the Jaguar brand under the Ford masterbrand, significant damage was done to the Jaguar brand as a result of Ford sharing componentry with its new acquisition. Consumers quickly figured out that the Jaguar X type was little more than a trumped-up version of the Ford Mondeo and not worth the premium being charged by the brand's new owners on the CD132 shared wheelbase platform. During the time Ford owned Jaguar, other reductions in quality also occurred and, eventually, the brand was sold to Tata Motors in March 2008.
Where to now?
Over the next year will it be interesting to observe how Michael Kors chooses to maximise its return on the company's investment in Jimmy Choo. Michael Kors would do well to take some time in understanding how other companies treat newly acquired entities. Regardless of the ownership structure, the charter for successful brand management doesn't change.
When wondering just what to do with the brand of Jimmy Choo, its new owners should stick to some fundamentals. Namely, keep the offer relevant to its target audience, keep the brand distinct from the competition and continue to earn the trust and esteem of loyal customers. Given the brand's history, innovation must underpin its new season range. The greatest synergy and upside of being owned by Michael Kors will stem from activities not directly associated with the brand. Better distribution models, effective inventory management, buying-scale and a greater focus on e-commerce are logical areas to focus when seeking to increase revenue and profit in Michael Kors niche fashion investment. Failing that, I'm sure a guest appearance by the famous shoes on a future sequel of Sex and the City may be a savvy contingency.
Nick Foley is the president of South East Asia, Pacific and Japan for Landor


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take this opportunity by my grandson to give you the purport of it, as well as I can recollect. I thanked you for the pleasure you had procured me of the General's conversation, whom I found a judicious, sensible, and amiable man. I was glad to hear that you possessed a comfortable retirement, and more so that you had thoughts of removing to Philadelphia, for that it would make me very happy to have you there. Your companions would be very acceptable to the Library, but I hoped you would long live to enjoy their company yourself. I agreed with you in sentiments concerning the Old Testament, and thought the clause in our constitution, which required the members of Assembly to declare their belief, that the whole of it was given by divine inspiration, had better have been omitted. That I had opposed the clause; but, being overpowered by numbers, and fearing more might in future times be grafted on it, I prevailed to have the additional clause, "that no further or more extended profession of faith should ever be exacted." I observed to you too, that the evil of it was the less, as no inhabitant, nor any officer of government, except the members of Assembly, was obliged to make that declaration.
So much for that letter; to which I may now add, that there are several things in the Old Testament, impossible to be given by divine inspiration; such as the approbation ascribed to the angel of the Lord, of that abominably wicked and detestable action of Jael, the wife of Heber, the Kenite.* If the rest of the book were like that, I should rather suppose it given by inspiration from another quarter, and renounce the whole.
* Judges, chap. iv.
By the way, how goes on the Unitarian church in Essex Street? And the honest minister of it,* is he comfortably supported ? Your old colleague, Mr. Radcliff, is he living? And what became of Mr. Denham ?
My grandson, who will have the honor of delivering this to you, may bring me a line from you; and I hope will bring me an account of your continuing well and happy.
I jog on still, with as much health, and as few of the infirmities of old age, as I have any reason to expect. But, notwithstanding the decay of my constitution, my regard for my old friends remains firm and entire. You will always have a good share of it, for I am ever with great and sincere esteem, dear Sir, &c
The Marquis de Lafayette. - The Adjournment of
Congress, and Dissolution of the Committee of the States.
Baltimore, 24 August, 1784. SIR, As it may be a satisfaction to the friends of the Marquis de Lafayette to learn, that his visit to this country has been extremely flattering to its citizens, and that his reception has been marked by every circumstance expressive of gratitude and respect, I thought it would give pleasure to you, of whom I have often heard him express the liveliest regard, to have it in
* Theophilus Lindsey..
+ Mr. M•Henry was at this time a delegate in Congress from Maryland. He afterwards served for several years as Secretary of War, during the administrations of Washington and Adams.
your power to convey to them this information. He is now with our late general at Mount Vernon, and is expected in this town about the first of next month.*
I imagine your official information from this country must be very imperfect, and may continue so for some time, unless Mr. Jay, who has arrived, accepts the Department of Foreign Affairs. You know, I suppose, that Congress left a committee of the States; but this committee is, in effect, at an end, without the form of an adjournment. I went down to Annapolis on the 20th instant, to relieve Mr. Chase (a delegate from this State), but I might as well have remained at home, for Mr. Dana and Mr. Blanchard had the day before signified their intention to return to their States. There being only nine members present, a motion was made by General Hand to fix the dissolution on those gentlemen, which would have been entered on the journals, had not Mr. Blanchard withdrawn just as the yeas and nays were about to be called. This put an end to the committee, as he did not choose to return.
Owing to this circumstance, we shall have no visible federal sovereignty before the meeting of Congress at Trenton. I dare say our enemies in Europe will construe this event into a proof of a spirit of disorder and disunion among the States, not distinguishing between the States and their fluctuating representatives, who cannot be always wise, always moderate · men. The truth is, the eastern delegates did not think a committee of the States necessary, and went into it merely because, that, without one, they could not have obtained the adjournment to Trenton. The passions and sentiments of Congress descending to the com
* The Marquis de Lafayette had been making a tour through various parts of the United States, and was now about to return to Europe. See Sparks's edition of Washington's Writings, Vol. IX. pp. 55, 74, 77.
mittee terminated in its dissolution, as might have been foreseen. The States, however, have been at no time in greater harmony with each other. North Carolina has adopted the five per cent impost. Several of them have passed acts to vest Congress with a power to regulate commerce, previous to our recommendation on that subject, while Rhode Island alone resists the impost.
Your name has been often of late mentioned in Congress, and your letters alluded to, in which you press for leave to retire; but your friends have as often hoped, that you would serve this country a little longer. We have made treaties, but we want to be certain that we are at peace. With the greatest respect, I have the honor to be, Sir, &c.
Versailles, 27 August, 1784. SIR, You have communicated to me an extract from the instructions, which Congress addressed to you on the Ilth of May last, which imports, that the United States will in no case treat any other nation with respect to commerce more advantageously than the French. This disposition is much the wisest, as it will prevent those misunderstandings, which might arise from the equivocal terms in which the 2d article of the Treaty of Amity and Commerce, signed February 6th, 1778, is conceived. But that the resolution of Congress on this subject may be clearly stated, it would be best, Sir, that you furnish me with it in the form of a declaration, or at least in an official note, signed by yourVOL. X.
self. I have no doubt that you will adopt one of these two forms. I have the honor to be, &c.
Passy, 3 September, 1784. SIR, I have the honor to transmit to your Excellency, by order of Congress, a resolution of theirs, dated the 11th of May last, which is in the words following, viz.
" Resolved, That Dr. Franklin be instructed to express to the court of France, the constant desire of Congress to meet their wishes; that these States are about to form a general system of commerce, by treaties with other nations; that, at this time, they cannot foresee what claim might be given to those nations by the explanatory propositions from the Count de Vergennes, on the second and third articles of our Treaty of Amity and Commerce with His Most Christian Majesty, but that he may be assured it will be our constant care to place no people on more advantageous ground than the subjects of his Majesty." With great respect, I am, &c.
Passy, 7 September, 1784.
* The same who afterwards so eminently distinguished himself by his eloquence in the early part of the French Revolution. - W. T. F.


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Our Purpose.
Providing women with an effective and comprehensive, Christian faith-based solution to life-controlling drug and alcohol problems in order to become productive members of society. By applying biblical principles, Adult & Teen Challenge endeavors to help people become mentally sound, emotionally balanced, socially adjusted, physically well, and spiritually alive. Our goal is to help residents establish a chemical-free lifestyle in connection with issues they identify as life-controlling, and to recognize that these skills and tools are transferable to future problems and challenges they will face.
The Director.
Mike Leonard
We believe that the application of Biblical principles leads to life transformation. Transformation is defined as "a change in composition or structure, to change the outward form or appearance of and to change in character or condition."
At Adult & Teen Challenge, we often see young women kind of stumble in the door. Most look haggard, disheveled, sickly, emaciated and some appear to be much older than their age. Their outlook is negative, gloomy, defeated, and hopeless. Many new clients have little to no personal belongings- and most have fear in their eyes.
Yet, it is beautiful to watch as Jesus comes into their hearts and changes them from the inside out. Their eyes begin to brighten. Hope replaces despair. Everything, from their appearance to their demeanor, begins to change. We know that real change is happening when they learn to speak the truth to themselves and others consistently and they begin to assume responsibility for their actions. They start dealing with their deep-seated issues, and we see a brand new woman begin to emerge.
Thank you for helping us help women recover their dignity and destiny.
Michael Leonard, Director
School History.
Adult & Teen Challenge USA began over 50 years ago as a Christian outreach to teenage gang members in New York. The ministry quickly grew & today there are 225 residential centers in America and over 1000 worldwide.
Adult & Teen Challenge Firelands.
Teen Challenge of the Firelands began as a vision of several local individuals who wanted to reach the addicted population in Huron County Ohio. Learn More.
To introduce people in addiction to a personal relationship with Jesus Christ, through discipleship & by applying Biblical principles.
The Curriculum.
TCOTF is a four phase program for women 18 and up who have decided to overcome their addiction to drugs and alcohol. A student must complete each phase in order to successfully complete the program.
Mission and Values.
2000 years ago, a teacher sat among prostitutes, thieves and murderers. Critics questioned why he would waste his time and associate himself with these "types" of people. But he ignored the skeptics and continued to invest in the lives of those who had no hope. He chose to spend time building relationships and restoring the lives of the most unlikely members of society. Jesus became their source of hope.
The teachings of Jesus are the same philosophies applied to each Adult & Teen Challenge program. Jesus taught love and forgiveness. Adult & Teen Challenge not only provides a recovery program, it provides a restoration program. When lives are restored through the teachings of Jesus they are changed forever.
Critics question why we spend our time and associate with those who are addicted. We ignore the skeptics and continue to invest in the lives of those who have no hope. At Teen Challenge of the Firelands we spend time building relationships and restoring the lives of the most unlikely members of society so that Jesus can become the source of their hope.


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Food has a huge impact on the way that you feel and the way your body functions. But did you know that eating the right anti-aging foods could even help keep your body stronger and more youthful as you get older? Check out the list of 10 powerful anti-aging foods below to start shifting your diet into one that will allow you to maintain your energy and help you look younger too.
Include These 10 Anti-Aging Foods in Your Diet
1. Nuts
The great thing about nuts is that there are so many to choose from and they're all delicious. They're packed with nutrients that could help reduce inflammation and cholesterol, thereby helping your body remain youthful. And in addition to eating nuts, you could also enjoy yummy nut milks like almond milk, which are fortified to easily provide you with nutrients like vitamin D and calcium.
2. Blueberries
When it comes to fruits that you should be incorporating into your daily diet, berries are a must. And blueberries, in particular, should definitely be on your grocery list. These have loads of antioxidants and they're super tasty. Because they could protect your skin and give your body a boost of vitamin C, blueberries are one of the best anti-aging foods.
3. Avocado
Pass the guacamole! Avocados are also considered one of the top anti-aging foods that you can indulge in regularly. They have phytochemicals and other nutrients that could help keep your body strong against the effects of aging.
4. Pineapple
Another fruit that you can indulge in guilt-free is pineapple. This tropical fruit contains high amounts of manganese that could support processes that will lead to the production of collagen. The result could be smoother and more youthful looking skin as you get older.
5. Olives
Olives contain healthy fats, along with phytonutrients that could protect your body's DNA, and that could lead to you feeling and looking younger. Experts recommend avoiding canned olives that go through a pitting process that could remove important nutrients.
6. Broccoli
There are so many great reasons to eat more broccoli. In addition to helping protect against disease, it contains lutein, which is important for eye health and brain function as you age.
7. Lentils and Beans
The wide range of lentils and beans that are available are all considered anti-aging superfoods, as they're packed with protein, fiber, and phytochemicals that support your body from head to toe.
8. Oatmeal
Here's another reason to start your day with some warm oatmeal: this food is high in beneficial carbs that boost serotonin to make you feel good. Plus, it could deliver plenty of fiber and energy to keep you going strong as you age.
9. Edamame
Edamame and other soy foods could help support the health of your heart and bones. And if you're a woman approaching menopause, soy could give you phytoestrogen that may help support your health and your mood. Just stick with organic soy.
10. Chaga Mushrooms
If you're a fan of mushrooms, give chaga mushrooms a try. These contain a variety of compounds that provide antiviral and antitumoral effects. Antioxidants also help protect your body against free radicals and disease.