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Experience Nature along rivers and streams
Out and about in the valley of rushing water
You really are on your 'own special' hike when you are beside water - walking through the natural world, listening to the rustling of the trees - as if they are telling you something - and breathing in the clear air...
Wassergedankenweg Gößfälle
Unique nature-jewel - On the other side of the valley from the Wassererlebnispark Fallbach water experience park, at the start of the Gößgraben and shortly before the Gößbach joins the Malta, are the Gößfälle.
Experience one of the loveliest waterfall ensembles in Carinthia: a harmonious triad of sound – shaped by Nature. The Gößfälle are a unique natural jewel with several viewing platforms, which offer magnificent points from which to appreciate the plunging masses of water, falling from up to 50 metres. The themed trail along the three tiers of the waterfalls, ending with a suspension bridge high in the air, confronts visitors with quotations by famous people on the subject of water, inviting contemplation, philosophising and pauses for thought. Immediately before the first waterfall, the water arena, with a platform reaching out into the water, invites one to linger and marvel. A water-themed trail leads from the water arena to the upper end of the Göss ravine. The individual places for stopping and resting are places of peace, at which one can listen to the constant roar of the waterfalls – but which should also encourage contemplation.
The short track to the first Gößfall – c. 150 m – is constructed in such a way that it can be negotiated successfully by the physically or visually impaired. Hiking here with toddlers is also not a problem.
The exit point for the hike is the "Gößfälle" parking area between the Zirmhof and Pflüglhof guesthouses.
After just c. 150m you catch sight of the lower Gößfall in all its glory. The underflow of the Gößbach forms a wild and romantic granite ravine, with massive waterfalls, flooded ledges and crystal clear pools. Immediately before the first waterfall, the water arena, with a platform reaching out into the water, invites one to linger and marvel. A suspension bridge at the end of the themed trail offers an imposing view once again into the upper part of the ravine. About one hour should be allowed for the climb up and back again.
Naturerlebnisweg "Malteiner Wasserspiele"
The Malteiner Wasserspiele are a particular place of interest in Malta. - The nature trail starts right beside the tollbooth at the Restaurant Falleralm.
The easy hike, which lasts c. two hours, is a real family experience and runs for c. 5 km along the Malta valley. On the way there is an impressive view of the Malta, as well as streams and waterfalls. The idyllically situated "Blauer Tumpf" or "Blue Pool" in the Schönau is the last of 18 stopping places. Some 1.5 hours should be allowed for walking back to the start. At the start of the hike one can buy a small information leaflet giving a detailed description.
Carinthias's highest waterfall - The Fallbach - opposite the confluence of the Gößgraben - plunges over a rock face here and thunders down 200m into the depths.
It is thus Carinthias's most powerful waterfall. The Fallbach forms the imposing start to a line of further waterfalls. Because of these magnificent waterfalls and untamed streams the Maltatal is considered one of the loveliest Tauern valleys.
The "Wassererlebnispark Fallbach" has a lot of information on the subject of water, a water-themed trail, a sandpit, reservoirs, climbing garden and much more. Playing with and by water is the main activity.


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If the government is investigating you or your company, the caliber of your lawyer will have an impact. Attorney Dan C. Guthrie, Jr., stands ready to help his clients overcome their legal challenges. His experience, skill and dedication in the defense of white collar criminal allegations make a substantial impact in his clients' lives. Proactive, independent and discreet, Dan understands the gravity of each situation and will work diligently to achieve positive outcomes. While based in Dallas,TX, Mr. Guthrie's criminal defense and whistleblower practice has a national scope. Call 214-953-1000 or complete the contact form to schedule your consultation.
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Map and Directions

subset: commoncrawl


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Ashdown offers limited edition Norman Watt-Roy pre-amp
Ashdown is to produce just 50 specially tweaked versions of its valve powered OriginAL pre-amp, each one adjusted to the specification of bassist Norman Watt-Roy and signed by him personally.
Watt-Roy has had a career spanning some 40 years and is regarded as one of the best bass players the UK has ever produced. Most famous for his stunning bass lines with Ian Dury and the Blockheads, he is a long time Ashdown amplification user.
The anodised aluminium front panel of the Norman Watt-Roy OriginAL pedal has been finished in Shoreline Gold to match Norman's famous 1962 Fender Jazz Bass, known as 'The Blockhead', which was his sole gigging and recording bass since the mid-'80s.
The pre-amps will retail at £379.
Info: www.ashdownmusic.com
The post Ashdown offers limited edition Norman Watt-Roy pre-amp appeared first on Music Instrument News.
Source: musicinstrumentnews.co.uk


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Three days before he was to leave office, President Dwight D. Eisenhower delivered his farewell address warning of the rise of the military-industry complex. Eisenhower described the "conjunction" of a large military establishment and arms industry unparalleled in American history and saw that its "total influence—economic, political, even spiritual—is felt in every city, every state house, every office of the federal government." In his new book, @War: The Rise of the Military-Internet Complex, journalist Shane Harris argues that the surveillance state and the defense contractors, tech giants, financial institutions, and telecommunication companies are forming a new alliance that will likewise shape cyberspace and American life.
In the wake of Edward Snowden's revelations about the National Security Agency (NSA) mass surveillance programs and cyber espionage operations, Harris echoes an argument that many in the technology and Internet freedom communities make: the cure has been worse than the disease. Harris is mindful of the very real threats that exist—terrorists using the web to organize, Chinese hackers stealing intellectual property, the vulnerability of energy grids, financial institutions, and other critical infrastructure—but argues that, "in its zeal to protect cyberspace, the government, in partnership with corporations, is making it more vulnerable." This is especially clear in the NSA's alleged efforts to undermine encryption and purchases of zero-days, unknown vulnerabilities that users and administrators have had no time to patch and address. These actions may allow the United States to strike its enemies more effectively, but also leave the vast majority of users in and outside of the United States exposed to attacks.
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While Harris writes that the "NSA is not the enemy," he clearly thinks that the agency, and its former director General Keith Alexander in particular, overstepped boundaries, exploited political opportunities, and hyped the threat. Intentions are ascribed to Alexander, but they are often derived from interviews with others—people in the room at meetings with Alexander. This use of anonymous sources is a necessity, as Harris argues especially as the Obama administration prosecutes the leakers of classified material, but does raise the question of how reliable critics engaged in bureaucratic turf battles with the NSA are in describing Alexander's thinking. In addition, how much presidents George W. Bush and Barack Obama understood about the expansion of the NSA's power remains unclear. In some instances in Harris' narrative, the White House enthusiastically embraces new technological capabilities. In others, it seems to be absentmindedly led by the NSA.
Harris hammers home the blurring of the boundaries between offense and defense. In almost all the cases he describes, the success of U.S. operations depends on active intelligence gathering and computer network operations. He also does a good job describing how intertwined the private and public sector are becoming as private companies take actions that were previously the responsibilities of states, such as developing and amassing arsenals of malware, publicly identify nation states as responsible for hacking campaigns, and sharing threat intelligence. At the same, the government is heavily involved in commercial markets. NSA officials warn of the risk Chinese and Russian hackers pose to banks, retailers, and other businesses, and these business in turn look to cybersecurity companies founded by former NSA, Defense Department, and Justice Department officials for their defense.
Given this blending obfuscates actors and interests, the book would benefit from a more rigorous typology. Many things are described as cyber war when they in fact are espionage or sabotage. Moreover, the book overstates how new and unprecedented cyber operations are. Harris describes the hacking of insurgents cell phones in Iraq and the planting of false information that leads to ambushes as an almost revolutionary breakthrough. As Jason Healey points out in his history of cyber conflict, A Fierce Domain, most of the change in cyberspace have been gradual enough for us to learn from the past. The Union cavalry, for example, used captured Confederate telegraph stations to send false telegraph messages.
Harris brings new details both to hacking cases that have already been widely discussed in the press and to those less publicly known. @War concludes by suggesting that governments will not be the dominant actor in cyberspace, "at least not from day to day." Rather, corporations will take the lead in defense, with companies increasingly making strong security a selling point for consumers. Yet these commercial pressures raises the possibility that the the military-Internet complex will neither be as stable nor as long lasting as the military-industrial complex. As Harris notes, ever since the Snowden revelations, the technology companies have been scrambling to distance themselves from the United States government, introducing legal and technical challenges to surveillance (see, for example, Microsoft resisting a government warrant to hand over data stored in Ireland, and Apple and Android introducing encryption by default on mobile phones). The military-Internet complex may come apart not because of the protests of the American people, but because of Google, Apple, and facebook have to satisfy customers in Brazil, India, and Russia.
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The Liberals issued a press release yesterday afternoon attacking Ontario PC leader Tim Hudak over his – and his caucus's – confusion regarding eco fees. It appears as if the Tories are uncertain as to who exactly will be made to pay for recycling these materials if they win the general election in October.
From the Liberal Press Release:
The Association of Municipalities of Ontario has issued a warning that Tim Hudak's policy on eco-fees risks higher property taxes for Ontarians, as the costs of safely disposing of hazardous products are downloaded onto municipalities.
"It is not clear from the platform who will pay for the safe disposal of these products however if it falls to municipal property taxpayers, this would be unfortunate. AMO supports the polluter pays principle as key to environmental stewardship and believes that manufacturers must pay the full cost of their goods, including safe, environmentally responsible disposal."
Shell games are designed to confuse, and Tim Hudak's eco-fee shell game is no different. In fact, AMO is not alone in their confusion about Hudak's eco-fee plans. Even Hudak's own caucus members don't have a clue what he would actually do.
Three weeks ago, PC MPP Ted Arnott told the media the only substantive change Hudak had was hiding the fee in the price. Arnott was clear: the producer-pay principle, originally introduced by Mike Harris in 2002, would stay.
Then, a week later, PC MPP Garfield "Mileage Man" Dunlop gave reporters a completely different answer. He said that the PCs would scrap the existing recycling program infrastructure but still require that hazardous products be recycled. The more questions reporters asked, the more it became obvious that neither Dunlop nor the PCs had a clue who they were going to charge to pay for the recycling.
Later that same day, PC "party officials" were forced to clarify "Driver" Dunlop's statements by saying Tim Hudak would make "taxpayers" pick up the cost. This despite the fact Hudak's platform failed to budget for any additional expenditure.
– – –
A press release from Tim Hudak and the Ontario PC's regarding eco fees can be read here.
The general confusion in the Ontario Tory ranks should cause everyone some measure of concern: if Tim Hudak has such a difficult time understanding that there is no difference between the 'taxpayer', the 'consumer', and the 'voter', then we are all in trouble.
Because saying the 'consumer' will not pay an eco fee but the 'taxpayer' will be held responsible assumes that the 'voter' is stupid, or simply not paying attention. Plain and simple.
– – –
An earlier version of this article referred to the above press release as being issued by the Association of Municipalities of Ontario, when it was, in fact, issued by the Liberal Party of Ontario. The article has been corrected, and I apologize for the mistake. Thanks to my readers for pointing this out.


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61 Edington Street, Berserker QLD 4701
8% returns - huge investment opportunity!
STOP are you after yield? Cash flow? Possible capital growth? Great tenants? Central location? Brick units? LOOK HERE!
– $520 x 52 = $27,000.00 gross income per annum.
– If you are after figures these units stack up.
– Fully renovated – nothing to do, collect rent and go to the bank.
– The seller is retiring his portfolio will have to go.
– You will have to do ZERO work on this investment.
– Perhaps for years to come.
– The hardest job will be checking the bank account.
– $27,000 a year income, purchase price $365,000 – Do the math.
– Positively geared properties are the way to go in this economy.
– No maintenance, close to everything. GREAT TENANTS.
– Have you been sitting back waiting, now might be the time to start OFFERING. Call Jason today!
It's all about the building, the maintenance, the tenants, the location, the cashflow, the economy and the coal mines.
Landsize : 741 squareMeter
Property ID : 392d2cc6-0c3f-f804-050d-2dc54fda8759
Lockable garage: 4
Jason Rayner
0422 390 391


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Welcome to
Ibiza Boho Weddings
It's All in the Details
Ibiza Boho Weddings specialise in Wedding and event planning in Ibiza. We work closely with our clients, helping them to plan and host their upcoming event free of stress and to make dreams happen. Everything can be arranged for you, as its all in the details which makes the day perfect. Working closely with you our team becomes family to ensure your day runs smoothly so you can enjoy your special day without any worries.
Whether you dream is a sunset beach wedding in the sand, a classic Ibizan finca in the hills or classic church wedding we can help arrange everything for you and be with you every step of the way.
Check Out Our Services
Leave It to Us
Wedding Venue Setup
Ibiza Boho Weddings is here to assist you with your Wedding Venue decor. We work with some beautiful designers and collaborate with a number of decor companies.
Contact us to see how we can assist you with the supply and design of your event, weddings, birthdays, club events and more...
Floral Arangement Coordination
Trust Ibiza Boho Weddings to take care of all your Floral Arangement Coordination details. We can assist you in developing a budget, help pick out style to suit your taste and venue.
From button holes to full table displays through to flower walls, we can help with all you need so you won't have to worry about a thing except showing up. We can guarantee your Floral Arrangement and Coordination will have those in attendance raving about the event
Wedding Music
Music is one of the most important aspects to creating the right ambiance at your wedding in Ibiza. To selecting the right DJ, live music from professional artists, saxophone or percussion, to your very important first dance and aisle entrance and exit tracks. We are here to help you select the right music to achieve this to complete your special day.
We can take care of all the details and arrangements so that you can focus on enjoying your wedding day. We make the effort to understand your exact needs and work with you every step of the way.
Wedding Decor
Not all tastes are the same, cream back drop or white? Macrame or dream catchers? Everyones taste is different. With Ibiza Boho Weddings decor professionals we can help you chose the wedding decor which is perfect for you, contact us so we can start to plan and make your Wedding Venue Setup extra special.
Ibiza Boho Weddings
Contact us to discuss your 2020 Wedding
Selecting the right venue for you is very important, from sunset beach venues, fairytale Fincas in the Ibizan hills, to modern harbour settings and traditional church weddings we can assist with them all.
Your group size and selections may help decide your final selection as various venues have minimum booking numbers, contact us and we can help suggest which venue which may best suit your needs.
Cutting the Cake....
Cutting of the cake, a tradition for many years. Cakes styles can be selected to match your wedding decor styling, bridesmaids or wedding dress, or be completely different the choice is yours.
Do you enjoy a high tier cake design, or minimal styling with cup cakes and one main cake level for your Ibiza wedding cake, we have a range of specialists who can work with you to help select your perfect cake for your perfect boho wedding cake style.
Extras to make the day complete
The extra decor, the lighting, popcorn machines to photo booths for the entertainment of your guests. Should you have things you would like on your day you only need to ask us.
Transporting your weddings guests can be a logistical nightmare, not anymore. Leave all the transport arrangements to us. We can arrange the brides vehicle, should you wish to chose an open top Mustang, or Rolls Royce, plus the guests transportation to and from your selected wedding venue, your in safe hands with us.
Photography & Videography
We can provide the best photographers and videographers Ibiza has to offer. From simple albums of your special wedding moments, to full packages including ceremony and party video footage.


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TPO plan offers solutions for safer roads
Consultants rode every route for study
Members of the city's Bicycle-Pedestrian Advisory Committee (BPAC) had only one day to provide consultants hired by the North Florida Transportation Planning Organization (TPO) with feedback after hearing the results of a study of inexpensive solutions to make Jacksonville a safer city for walkers and cyclists.
The meeting was held Aug. 6 in the Training Room of the Ed Ball Building near City Hall. The window in which the consultants would accept comments from the public closed August 7, said Marci Larson, Public Affairs Manager for North Florida TPO. The consultants will present final recommendations from their study before the four-county TPO board Thursday, Sept. 10 at 10 a.m. at TPO headquarters in San Marco, she said.
North Florida TPO is a federally funded, independent regional agency for the counties of Duval, Nassau, Clay and St. Johns. The one-year bicycle and pedestrian study was an update to the TPO's 2040 plan for the region, which was approved by the TPO Board in November 2014, said Larson.
Instead of studying bicycle and walking routes for the entire Duval Country area, the consultants selected the specific focus areas of Riverside, San Marco and the Beaches, said Theodore Petritsch, of Sprinkle Consulting Group, which was hired by the TPO to conduct the study. Petritsch said the key idea of the plan was to provide "low-cost solutions" that could be implemented quickly "so you can get from point A to point B sometime next year."
The idea is to get the plan implemented fast, Petritsch said. "It won't be worth the paper it is written on if it is not implemented within five years."
The cost of the study for the three focus areas was $110,000, said Larson. A connectivity study linking downtown to the beaches cost $24,000, said Elizabeth De Jesus, TPO Commuter Services Manager.
'Dire' need for bike/pedestrian plan
During the meeting, Petritsch presented an overview of the study, which included maps charting safer bike routes through San Marco and Riverside. A map outlining areas where different facilities could make roadways safer for cyclists was included. In addition, a map delineating frequent bicycle and pedestrian routes gleaned from the public comments was on display. Petritsch said he and the other consultants had personally ridden every route within the study.
Even though they had only one evening to form a response to the study, members of BPAC came up with a list of 13 recommendations, which they hope the consultants will incorporate into their final presentation before it goes to the TPO Board and other transportation agencies in the Jacksonville area. See sidebar for BPAC's recommendations.
BPAC Chairman Christopher Burns of San Marco said he appreciated the effort made by Sprinkle to discuss their findings with BPAC. Members might have made more suggestions if they'd had more time to formulate their concerns before the time for public comment ended, he said in a phone interview after the meeting.
"Part of the problem was the way the plan was disseminated before the meeting. Many of us were hearing the explanation for the first time," he said.
For Larry Roberts of San Jose, a BPAC pedestrian representative, the plan sounded good. "To see what you can do quickly makes sense," he said. "You have to realize that you can't fix everything tomorrow."
The need for bicycle and pedestrian planning in San Marco and Riverside is "dire," said Burns.
"I am grateful for the TPO's concern and efforts to upgrade and advance bicycle and pedestrian planning," he said. "The last plan completed for these areas was done in 1999, more than 16 years ago. Since then, the numbers of pedestrians and bicyclists have exploded. The popularity of walking and bicycling for transportation in Riverside and San Marco is undeniable. The TPO's studies have come to the right conclusion – the City of Jacksonville must provide safer, better, and more accessible pedestrian and bicycle facilities in order to keep up with its resident's demands.
"In these communities, many roads have excess capacities for cars," Burns continued. "The number of lanes could be reduced without causing congestion and bike lanes/sidewalks could be installed very cheaply. Bike lanes should be installed whenever possible. Sidewalks should be installed on both sides of every road in these communities – no exceptions."
Burns said the City of Jacksonville has retained its own consultant to develop a new bicycle pedestrian master plan for the entire city. He said it should include short-run, medium and longer-range planning and hopes the consultant will consider bicycle and pedestrian traffic counts, crash statistics, analysis and specifics on the types of facilities, such as sidewalks, cross walks, traffic signals, bike lanes, and bicycle parking that can be utilized.
"The TPO studies are a good starting place," he said. "It is up to the City of Jacksonville and its neighborhoods to follow through on the important recommendations and not simply allow the studies to collect dust and act only as paper weights on some bureaucrat's desk."
By Marcia Hodgson
Resident Community News


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President's Corner
Hello TCSHRM!
Ten years ago, while a co-worker and I were talking in our office, she casually mentioned "You should join TCSHRM". I had never even heard of TCSHRM…but I quickly viewed the website and within five minutes I had joined Twin Cities SHRM! From there, I rapidly became more and more involved in our great organization - I started volunteering on the mentoring team shortly after I joined, and within three years I was serving on the board of directors. That brief conversation with my coworker launched my trajectory towards tremendous professional growth and countless development opportunities.
The urging of my friend for me to join was life changing for me – even though I had never heard of TCSHRM, the suggestion to "check it out" was all it took to get me started.
So- my challenge to you now: What friends, co-workers or associates do you know who could benefit from membership with Twin Cities SHRM? Make the suggesting a little bit sweeter with our new membership promotion that we launched at our March Chapter Meeting: When you "Refer a Friend" to TCSHRM, they will receive $20 off of their membership, and we'll thank you for the referral with a $20 Amazon Gift Card!
At TCSHRM, we recognize that many of you work within larger HR teams – and we appreciate the value added when the entire team can grow together. We want to facilitate this effort with our new corporate discount program: TCSHRM now offers discounted membership rates when five or more members from the same company join collectively. Now your HR department can learn, network, and take advantage of the many TCSHRM membership benefits as a team!
We want to get the word out about the many incentives to join TCSHRM! We are moving HR forward in the Twin Cities - networking opportunities are embedded within all of our events and programming, and the ability to grow and develop outside of the office is priceless.
Your call to action is to spread the word and tell your colleagues and friends about all the wonderful things TCSHRM has to offer. Sometimes a casual conversation and a click of the mouse can make all of the difference. It did for me and it can for you and your team!
We are moving HR forward - come with us!
Yours in Service,
Sue Kruse, SHRM-SCP
TCSHRM President
President's Corner
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Demonstrations against the Spanish Supreme Court ruling sentencing Catalan independence leaders are continuing in Barcelona on Sunday, September 20.
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"Pandora", Guatemala – another spectacular micro-lot from Finca El Injerto that cannot be missed! Perfect to get the holiday season ball rolling. Tastes: Creamy, peach nectar, winy.
Here is some information on this very special coffee from Arturo Jr:
The lot name is Pandora and it is with this lot that we have won the 1st place in the Cup of Excellence many times. The Pacamara trees are approximately 22 years old and grow between 1800 to 1840 metres above sea level. This is a special microlot, picked by special pickers and given a special treatment through the wet and dry mill. The coffee is dried on African-style beds inside a greenhouse to control temperature, humidity and shade. All this helps to really make the flavors brighter, more intense, and to give long life to this coffee.
More about El Injerto
Finca El Injerto is located in the La Libertad region in the province of Huehuetenango in western Guatemala. The land was first acquired in 1874 by Jesus Aguirre Panamá, originally planting crops such as sugarcane, corn, beans and tobacco. In 1900 he began planting coffee plants and named the farm El Injerto. The farm is now run by father and son, Arturo Sr & Jr, the 3rd and 4th generations to be managing the farm. Together they've created one of the most progressive and celebrated coffee farms in Central America.
Full details on product page.
Visit our online coffee shop for this juicy coffee if you're outside Toronto or Vancouver.


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The Golden Tree and the Gift
Today's Miracle Monday comes from the pages of the February 1948 issue of The Gospel News, originally titled, "A Vision," written by Sister Marietta Ruzzi.
On Thursday December 11, '47 while lhe Ladies Uplift Circle was united in fasting and prayer at the Divine Church, Detroit, I saw the following vision:
"I saw a beautiful tree which stood right in front of the pulpit, where the sacrament table stands. This tree was all gold, even the leaves and the fruit were gold, and its brightness was beyond description.
The branches of this tree extended from one wall to the other, and the height of it was to the ceiling.
In front of this tree stood a man, whose brightness was brighter than the noon-day sun. He had a beautiful smile on his face, and it astonished me immensely to see the wonderful splendor of him.
After I beheld this tree and this man, I noticed at the right side entrance of the building, the ministers of The Church of Jesus Christ were entering; each of them was walking up to the front to meet this man who stood in front of the beautiful tree, where he already had his arms outstretched to welcome them.
He then greeted the Ministers by shaking their hands, and while doing so, he placed something shiny in their hands. I could not see what it was, but it was something very brilliant. After the man placed it in their hands, they would clasp their hands very tight, and lifted their eyes towards heaven as they walked away from him having a beautiful smile on their faces."
On Sunday morning, I beheld this same experience when the young people sang before the opening of the service.
Editor's Note: Let's thank God that our ministry is blessed by Jesus Christ. Why not pray for the ministry in your branch today, asking that Jesus gives them what they need to accomplish the work He's given them to do?
This article has undergone ministry review and approval.


text: Last Friday night I went to this party with one of my buddies and wound up doing something I never thought I'd ever do. We were all sitting around listening to some music, smoking some blunts, drinking some beers, and talking with each other just having a good time. I started talking about sportbikes with this guy and he asked me if I wanted to go in his room and watch some sportbike movies he'd made so I said "hell yea man lets see 'em. So we go into his room and he closes the door behind him and I sit down on his bed next to his desk while he pulls up some of the videos. He started clicking on videos he had saved in a " movie " folder and a couple of movies in he opened up this video that showed a guy getting fucked in the ass by another guy. He just smirked and closed the video and opened up some more sportbike videos.


text:
UMMS Affiliation
Department of Microbiology and Physiological Systems
Publication Date
Document Type
Hemic and Immune Systems | Immunoprophylaxis and Therapy | Maternal and Child Health | Respiratory Tract Diseases | Viruses
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Maternal immunization is an option to increase maternal antibody levels and protect infants from infection. Here we assess the efficacy of virus-like particle (VLP) vaccine candidates containing stabilized pre-fusion (pre-F) or post-fusion (post-F) conformations of the RSV F protein and the attachment RSV G protein in a maternal immunization model using cotton rats. VLP vaccines containing RSV F and G proteins strongly boost pre-existing RSV immunity in dams preventing their perinatal drop in immunity. Boosting is stronger for the pre-F VLP than for the post-F VLP or purified subunit F protein vaccines, giving an advantage on mothers' protection. VLP immunization of dams provides significant protection to pups from RSV challenge and reduced pulmonary inflammation. Collectively, our results show that a VLP vaccine with RSV F and G proteins is safe and effective for maternal and adult vaccination.
Rights and Permissions
© The Author(s) 2018. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
DOI of Published Version
Nat Commun. 2018 May 15;9(1):1904. doi: 10.1038/s41467-018-04216-6. Link to article on publisher's site
Journal/Book/Conference Title
Nature communications
Related Resources
PubMed ID
Repository Citation
Blanco JC, Pletneva LM, Cullen LM, Otoa RO, Patel MC, Fernando LR, Boukhvalova MS, Morrison TG. (2018). Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model. Open Access Articles. https://doi.org/10.1038/s41467-018-04216-6. Retrieved from https://escholarship.umassmed.edu/oapubs/3469
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Hemic and Immune Systems Commons, Immunoprophylaxis and Therapy Commons, Maternal and Child Health Commons, Respiratory Tract Diseases Commons, Viruses Commons


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Key Points
Neutralization of IFN-γ with emapalumab can reverse severe, refractory hemophagocytic lymphohistiocytosis.
Neutralizing IFN-γ did not impair control of multiple viral and other infections in a severely ill patient.
Visual Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an immune-regulatory disorder treated conventionally with corticosteroids and etoposide.1,2 Patients with HLH generally have a poor prognosis and there is considerable morbidity and mortality, largely related to persistent HLH, intercurrent infections, or organ failure.3 Conventional therapy may contribute to these problems due to its myelosuppressive or broadly immunosuppressive effects. Although data are limited, it is generally believed that the prognosis is worse for patients who do not respond to standard treatments.4 Salvage therapy for refractory HLH often involves T-cell–depleting agents, such as alemtuzumab, which produce profound and prolonged immune suppression.5 Animal models have demonstrated a strong causal role for interferon γ (IFN-γ) in the development of HLH,6-9 and data from patients with either primary or secondary HLH have demonstrated elevated levels of IFN-γ or IFN-induced chemokines.8,10-12 These findings have led to the development of emapalumab (NI-0501; Novimmune SA), a fully human anti–IFN-γ monoclonal antibody, which is being tested in a phase 2/3 study as therapy for primary HLH (NCT01818492) and was recently approved by the US Food and Drug Administration. It is hoped that the development of newer targeted therapies such as emapalumab will improve survival in patients with HLH by directly targeting disease-driving pathways and avoiding the myelosuppressive effects of etoposide and the global/persistent immunosuppression of serotherapies.
Case description
We report here a case in which refractory, Epstein-Barr virus (EBV)–associated HLH was successfully treated under an emergency investigational new drug application with the investigational agent emapalumab, despite severe preexisting comorbidities, including multiple life-threatening infections.
Clinical data are from the Cincinnati Children's Hospital clinical laboratories. Chemokine levels were measured by Novimmune via MSD, a Meso Scale Discovery assay. Parental consent was obtained for participation in institutional review board–approved research studies, per the Declaration of Helsinki.
Results and discussion
The patient is a boy of southeast Asian descent who presented at 20 months of age with acute EBV infection and essentially all diagnostic features of HLH as defined by the HLH2004 criteria (fever, hepatosplenomegaly, bicytopenia, hypofibrinogenemia, hyperferritinemia, elevated soluble CD25 [sCD25], and marrow hemophagocytosis; natural killer function was not measurable because circulating natural killer cell numbers were too low). At initial presentation, he was noted to have 3.1 million copies of EBV per microgram of DNA in the blood, and cytomegalovirus (CMV) was detected in the urine (but not blood). He was initially treated with etoposide and dexamethasone per the HLH94 protocol and also received rituximab and IV immunoglobulins. Despite this therapy, his clinical status progressively deteriorated. His cytopenias rapidly worsened after initiation of etoposide and his absolute neutrophil count remained below 500 for >5 weeks. After 1 month of therapy, he was transferred to our hospital at which time he had persistence of all HLH features including daily fevers, worsening pancytopenia, and persistent EBV viremia of 3.8 million copies per microgram of DNA.
Shortly after transfer, the patient had severe gastrointestinal bleeding, seizures, and central nervous system hemorrhage, leading to intubation and mechanical ventilation. He also experienced acute renal failure requiring continuous renal replacement therapy, then intermittent hemodialysis. Infectious workup revealed multiple viremias (EBV, CMV, and adenovirus; Figure 1), bacteremia (Escherichia coli), and fungemia (Trichosporon species), all present concurrently. Brain magnetic resonance imaging revealed a large frontoparietal hematoma, later thought to represent a fungal abscess. Notably, CMV was present at very high levels in the blood (18 million IU/mL), whereas adenovirus was detectable at more modest levels (1000-30 000 copies per milliliter in blood). Further standard therapy for HLH was deemed to be futile and salvage therapy with alemtuzumab was considered to be contraindicated due to the presence of severe infections. The patient was not enrolled in the current emapalumab treatment trial (because he met the study exclusion criterion of multiorgan failure), but was treated on an emergency investigational new drug as a last therapeutic resort, though his death was felt to be imminent. Treatment with emapalumab was initiated along with antiviral (ganciclovir, later switched to brincidofovir for adenoviremia), antifungal (liposomal amphotericin), and antibacterial medications. The patient received transfusions of multiple blood products (averaging 5 products per day initially), including daily neutrophil transfusions, for the treatment of fungemia, bleeding, and anemia. Dexamethasone was initially continued, but was then stopped by day 11 due to concern regarding persistent fungemia.
Treatment of HLH with emapalumab alone resulted in resolution of all clinical symptoms and normalization of clinical laboratory parameters (Figure 1). Within hours of receiving the first dose of emapalumab, the patient's fever resolved. Approximately 1 week after initiating emapalumab, serum ferritin began to fall rapidly; sCD25 fell with slightly slower kinetics. Within 2 weeks of starting emapalumab, gastrointestinal bleeding resolved, fluid and neurologic status improved, and the patient was extubated. Transfusion support was weaned off by day 21 and neutrophil and platelet counts progressively improved, reaching normal levels within 2 months. Hepatic dysfunction and coagulopathy resolved within a month. Renal function recovered (glomerular filtration rate increased to >60 mL/min) over 3 months. The patient received emapalumab for 14 weeks. Treatment was well tolerated with no clinically significant adverse reactions noted.
Remarkably, during blockade of IFN-γ with emapalumab, all infections resolved with supportive antimicrobial medications and cessation of etoposide and dexamethasone. Bacteremia did not persist and fungemia resolved by day 14 of treatment. EBV fell rapidly starting 1 week after emapalumab and became undetectable by day 160 (Figure 1). CMV viremia resolved in ∼3 weeks and adenoviremia resolved by 7 weeks. By the end of therapy, all HLH-related symptoms had resolved, all infections resolved (brain hematoma/abscess eventually resolved ex vacuo), the patient had made a complete neurologic recovery, and he was able to stop dialysis. Hematopoietic stem cell transplant was not pursued because the patient had no suitable donors and genetic workup did not reveal HLH-associated gene mutations. The patient was discharged from the hospital after 174 days, and he has been off of all therapy for >36 months with no evidence of unusual infections, recurrent EBV, or HLH. He is developing normally and is in excellent health.
Three features of this case are remarkable. First, despite prolonged prior immunosuppressive therapy, the patient had extremely elevated CXCL9 and CXCL10 levels (Figure 2). These chemokines are specifically produced in response to IFN-γ and such levels suggest severely elevated in vivo IFN-γ bioactivity.13 Second, these chemokines promptly decreased upon the initiation of emapalumab and fell to normal or near normal levels within about a week. Together with the clinical response, these data indicate that emapalumab was able to neutralize IFN-γ and that such monotherapy (albeit with dexamethasone for the first 10 days) effectively halted severe and refractory HLH. Although animal models have predicted this effect, this is the first clear demonstration of such therapeutic potential in humans. Third, despite IFN-γ neutralization, this patient was able to recover from multiple infections that would ordinarily be considered unsurvivable. Although treatment with emapalumab allowed for cessation of conventional immunosuppressive therapy, which was likely impeding infection control, our findings call into question the role that IFN-γ plays in antiviral resistance in humans. Interferons, both type I (α/β) and type II (γ), are thought to play important roles in viral resistance. However, our patient was able to clear persistent EBV (and other infections) while on emapalumab, even though supportive antivirals are of little or no benefit for EBV infection. Paradoxically, our findings suggest that IFN-γ may have been contributing to immune paralysis in this patient. Experimental models have demonstrated immune paralysis in response to type I interferons only,14,15 though IFN-γ is well described as an inducer of various immune-regulatory pathways.16,17 This patient's course suggests that IFN-γ blockade is a rational and attractive strategy for targeted treatment of HLH, and agents such as emapalumab will teach us much about the biology of IFN-γ in humans.
The authors thank Didier Halimi and Innotio for assistance with editing and figure preparation.
Contribution: D.T.L. and M.B.J. wrote the report; Q.B. and C.d.M. assisted in gathering data and/or editing the manuscript; and C.d.M. additionally provided chemokine data.
Conflict-of-interest disclosure: C.d.M. is an employee of Novimmune SA. M.B.J. is a consultant for, and serves on a scientific advisory board for, Novimmune. The remaining authors declare no competing financial interests.
Correspondence: Michael B. Jordan, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, ML7038, Cincinnati, OH 45229; e-mail: firstname.lastname@example.com.


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we got a very late start so it's actually more like an afternoon and evening at the beach but nevertheless it was a truly enjoyable day.
we drove from Waterloo down to Long Point across some absolutely beautiful small town scenery in Southern Ontario. it was the first time i had ever been to Scotland(a small hamlet on the way), the town of Simcoe is glorious and Long Point itself is very obviously a tourist town all summer long.
we met Jackie and Barry there where they had been camping for a couple days and we promptly went body surfing on the waves of Lake Erie. the water was surprisingly warm for a body of water that size and well, it was a ton of fun. we then settled down to a vigourous game of Settlers of Catan during which i came in 4th (i can't seem to win that game ever) and then supper and a campfire. the campsite was perfect; right by the beach and it was extremely quiet even though the place was packed with campers. it's well worth your time if you're in the neighbourhood.
i just appreciated the chance to breathe and do nothing for a good long while. it was truly glorious.
Thursday, September 2, 2010
a day at the beach
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Awesome cover art by Ogden Whitney; interior art by Matt Baker, and more; scripts by Richard Hughes, Ruth Roche, and more.
The cover story alone, "Jailbird's Romance," would cost you a couple of grand on the collector's market! It's drawn by the demented duo that gave you Herbie Popknecker: Ogden Whitney and Richard Hughes.
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Some people just don't matter much
There are people who do not matter much.
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In this country, by dint of race, gender, class or status, some people just don't seem to matter. Apparently, Tammy Jackson is one of them.
No other conclusion is


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Sneak peek of the new Phoenix Social Club Dubai
- A new post-prohibition bar, Phoenix Social Club, to open in Dubai
- The bar-and-lounge concept will be located at the H Hotel
- It is working on partnerships with music academies around the world to bring new talent to the venue every month
Dubai's busy nightlife scene will have a suave newcomer next month with the opening of a post-prohibition lounge and bar, the Phoenix Social Club.
Opening at the H Hotel on Sheikh Zayed Road, the venue is promising a 'modernized nostalgia' aesthetic with the owners describing it as a place where old and new collide and featuring 'fine sharing' dining and drinking and upbeat vibes.
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The team is working on partnerships with music academies around the world to bring new talent to the venue every month to keep the sound fresh and accompany the monthly supper club parties.
The Phoenix Social Club opens in June 2019.


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The mysterious Glaswegian synth-pop trio, Chvrches, finally stepped into the spotlight at Nottingham's Rescue Rooms last night, on the closing night of their UK tour.
An assorted blend of fans from young to old, rocker to bopper, demonstrated Chvrches versatility but their dance moves were almost as static as the trio's, which were nothing short of dissimilar from their animated support act Young Fathers.
Mayberry, Cook and Doherty kicked off the set with debut single "Lies" showing-off the angelic vocals of lead vocalist Mayberry.
Her cute stature resembled an essence of innocence but she confirmed how rock n' roll-esque she really was as she sipped from a mug and whispered: "This isn't really a cuppa tea, it's a mix of seven spirits and super hard-core."
Her distinct Scottish accent complimented stunning vocals coated over their trademark synthesiser chords.
Recover, the lead single from their current EP had the crowd singing along with its catchy chorus and hypnotic bass beats.
The trio were flawless.
Doherty played keys and synth pad until an unprecedented swap with Mayberry where he took to the front to showcase his gravelly voice and sing his song "Tides" while she had the odd play with Doherty's synth pad.
Her numerous slip-ups there proved she was more convincing as a vocalist though.
The trio's encore was a heavily guitar driven cover of Prince and The Revolution's "I would die 4 u", revealing the band's heavy appreciation for early Prince. If the rest wasn't enough then this definitely left their fans astounded, satisfied and deeply in awe.


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I just finished the first few episode of Shirobako. I feel bad for animation studios now. Is Aoi supposed to make me fall for her?
>I feel bad for animation studios now.
why? The people in this show are all happy to be at their job, it's stressful yeah but they're doing what they love.
But dont they get paid shit? I guess that's just nippon.
>happy to be at their job
except nee-san
She's not an animator, she's an existential black hole
>when they say they are daijoubu but you know they are not daijoubu
>tfw you'll never dp Aoi with your bro tarou.
The really sad thing is that many of the characters went to college to get their skillset and they are still not making any money.
Fuck you. Tarou belongs to Yano.
Is college in Japan as expensive as it is here?
The kinds of colleges that train for that sort of work are usually 2-3 year diploma affairs, and the tuition is much lower than an academic university would be
I'd support Aoi as her husband so she has more to buy donuts.
I want to support Midori through college.
>The kinds of colleges that train for that sort of work are usually 2-3 year diploma affairs, and the tuition is much lower than an academic university would be
Tht is the same as america. The 'art institute" and 2 year computer animation colleges are cheap and offer low wage jobs.
>According to Salary.com, the average salary for an animator in the United States is US$55,000. According to the Arts Institute of California, the average starting salary for animators who graduate from that institute is US$31,000.
Still better than Japanese animators, but low by north American standards.
55k is higher than the GDP, so that's not a bad career to find yourself in, and 30k is certainly not bad for an entry-level position in a skill-based field.
The tricky part would be actually starting your career, because the demand is so abysmally low in the US, and dealing with the crushing depression of using your talents gained through years of training and passion just to dick around in flash for 9 hours a day.
Been off /a/ for a while. Is this PA Works' newest show? And more importantly, is it good?
Pre-recession they various AI art colleges had over 80% employment rate for animators.
Coincidentally the AI websites only publish 2008 employment rates for graduates. It is probably a lot lower now but they keep that number a secret.
>because the demand is so abysmally low in the US
Ain't that the truth. Even for 3DCG, the only really prolific work you can get is in advertisements and shitty network babby cartoons. Maybe a brief stint on the newest Bayformers if you're lucky.
You will never never go play pool with them. ;_;
Any with cute chief animator chan?
Definitely, especially after the abomination that was Glasslip.
Honestly, I think that these gentlemen are more interesting than the females.
Maybe because most anime that I've seen have female-centric casts, so this anime is quite a change for me.
how bad was glasslip anyway? all i know is that /a/ reached a mutual consensus on it which says a lot.
It wasn't the worst thing ever, but it was just completely mediocre in every aspect and respect, an utter let down in every attribute that held any promise, and completely failed to deliver on anything that it built towards.
It dragged its feet for an entire cour with nothing, and by the time we reached the end, we realized that it was it. There was nothing more than that, the pointless nothing throughout was the entire sum and content of the show.
It wasn't bad so much that it was so utterly without anything positive that it actually makes you feel angry for having watched it. It was the animation equivalent to eating toiletpaper
>give the guys hardly any screentime
>most of that goes to Tarou and Director being faggots
>get rid of Ochiai and Honda without any mention of new male employees, just more cute girls
Endou's stuff was good though. I just hope we're not going to move even further from the somewhat balanced workplace for more cute girl shenanigans now that we've got highlights-chan and Ghibli-chan as well as retaining all the previous girls.
I'm really going to miss Honda.
Will Zuka ever get a good role?
Me too
Even though most of the other guys were more attractive he was somehow the most appealing
We're probably going to see fewer consistent male characters, but more one-off characters showing of f their positions in the industry.
I also don't doubt that Nabe P will get a lot more screentime and presence now. Honda's departure creates a space in the character dynamic, so we'll likely have a new male fill that.
Yes, and then she'll botch it.
She's a bank employee.
More and more coworkers around me are getting silently fired. I guess that's one thing to hope for when you're stuck looking for a job.
Honda will be back with cakes, he even said so himself.
A man has to make his dream come true himself.
Why is it that in every groupshot, Mii-chan is always touching another girl, and Zuka is always sequestered from the rest?
Aoi's sex with Tarou must be awkward.
She strikes me as the kind of woman who would intimidate and scare a guy like Tarou. Especially when you think of all the pent-up stress and frustration that she'd be releasing all at once in a ravish barrage of sexual aggression. She'd chew up a little guy like Tarou and spit him back out
After the first time, I don't think he'd want any more
but she wouldn't stop
they put all these cute girls in there to stop you from killing yourself because this shit is too depressing otherwise.
How can people be happy at their job? It literally drains your soul.
this show is made to make you feel bad and spend money on the industry
Cutest bako.
Goth-loli sama is a chief animator?
I thought she was just an entry-level intern. She looks young enough to be in high school.
It literally fucking says "chief animator" every time she shows up
And it wouldn't have been the big deal it was that she did the clean ups for Sugie if she was just some newbie.
>Goth-loli sama
>better than God of eight cuts
I want Tumblr to burn
Tarou doesn't really strike me as the kind of guy who would be intimidated by a girl his age, his interactions with Aoi feel pretty equal if only because of his obliviousness and I expect the sex would be like that too. He'd expect to be on top, probably think he's an amazing fuck for lasting more than five minutes, and ultimately leave her unsatisfied.
and thats when the fun begins
Shirobako: best reaction faces of 2014?
no thats chaika
i think that goes to nozaki-kun
why not both
It would be really great if she would descend into doing eroge and hentai work exclusively and ultimately go into JAVs, while all her friends make real proper careers and all she could do would be to despair about the path she chose, and then the Yakuza would finally sell her as a sex slave to some chinese businessman, making her disappear from her circle forever. But Shirobako is supposed to be a light-hearted show I guess, so one can only dream.
she's like 50
I want to ask goth loli out on a date in the typical jap fashion of bowing your entire torso with your eyes closed.
Those hips were made for the soapland industry, she's wasting time chasing a dream that will never come to fruition.
i want to end suffering
Is this accurate? How does the episode director survive on this salary? The people who earn less than him are all much younger and don't have to support a family.
Living in Japan is cheaper?
Musashino is still Tokyo (although kinda in the suburb).
Mi chan, please.
Nabe P's job seems awesome. I want to earn capital and work for my studio.
They have cheap korean brothels and police doesn't bother them while they sleep on the street after a night of heavy drinking.
I want to make Oi-chan happy
>Honda's departure creates a space in the character dynamic, so we'll likely have a new male fill that.
>implying it won't be Okitsu taking his place.
There's no money in the industry. This is a notorious fact. The few married ones that I'm aware of are married to other people in the industry, so they have double income, at least. In any case, they're not rich.
I want to make goth loli happy
Anyone want to bully Ema? It's been a year since I've seen Ema bullied.
But you don't have to do anything when her very existence and life style bullies her.
Is she stupid btw? I thought it was common sense to start looking for new job before you quit your current job.
Yeah, Misa was hit in the head with a ricochet as a child during the break up of the USSR.
It is and even the other characters in the show said that she made a dumb move there. Quitting after less than a year makes it hard to recommend her too.
Mii-chan was confirmed dyke just from her wadrobe.
With fatty and kirito gone, based Tarou will finally have a harem he rightfully deserves.
The three best looking people in that picture are General Manager, Nabe-P, and Goth Loli-sama.
She's a cute grill. Realistically speaking you'll never run into real trouble in life, if you're a 7/10 or above, which all anime girls are by default. Just dispense some blowjobs here and there and you'll find someone who'll be willing to employ you.
>page 2
>it's the
Being a cockwhore isn't sustainable long-term though. You get maybe a decade at best.


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Employing a qualified professional moving company can easily save you tons of precious time. Lets face it; moving costs not only money and yet time also. When ever moving you will likely put in tons of hours very carefully packing your items, together with organizing boxes so as to have an idea exactly what boxes contain which items for unboxing when your arrive at your new place. There are really by no means 2 ways about this it is definitely time consuming. So simply by hiring an offical mover in Windward Circle, La to either move you across town, out of town as well as across the country you can certainly save tons of time by simply letting the moving company that you hire pack your belongings for you. Considering that these professionals will be able to totally load and unload your whole entire home or apartment.
You may possibly believe that "doing it yourself" could be the most suitable form of cost savings when ever moving. On the flip side, lot of people do not really consider not only the amount of your time which it requires move, but also the amount of cash which it can need to move. Numerous things in which a lot of people do not necessarily allow for is: you have to rent out a box truck to move, gasoline and trip charges, boxes, shatterable items containers and safety and security measures, a 2nd team of hands also a healthy back for moving the huge things, downtime from your job to move: due to this fact missed out on wages for the most parts. These are simply just some of the expenses when ever looking into the DO-IT-YOURSELF moving aspects. Along with having movers move your house or even apartment, you are merely looking at paying a single flat price. The skilled professional movers conduct all the hefty lifting, shouldering things down the staircases, placing things inside the truck. Anytime you employ the services of a complete service mover within Windward Circle these professionals are going to even help you pack, move and then unpack your items.
Looking into that professional movers are normally regularly moving objects from one apartment to another, or from one home to another; they have a fair bit of prior experience moving your furniture pieces and delicate and fragile belongings. Considering that such these guys are without a doubt much less than likely to damage your belongings. Similarly these guys have reduced level for injury as these individuals are constantly putting their bodies under the difficult demand every day and their physiques have already become adapted to the task. Lots of folks when attempting to move or hoist bulky belongings often hurt themselves: this particularly comes to pass even more in the course of moving given that you are really moving a large number of heavy items throughout you home or apartment or condo. Therefore, spare yourself the trouble and safety of your body and employ the services of our professional moving staff.
In case you have probably ever before moved before then you will definitely understand that aiming to have all the correct boxes as well as furniture in the appropriate place in the time of a move can most likely be discouraging. By having items getting off loaded from a truck in order to making it positive it is without a doubt not actually only labeled right, still, gets to the most suitable room. Loading as well as moving might be as compared to attempting to construct a 5,000 piece puzzle. Packaging, labeling, fitting all the boxes grouped collectively so these professionals remain organized; next attempting to ensure that they will get to the correct room at the time they get off the truck. This stuff is normally what is actually all involved anytime you are moving and coordinating your home or apartment or condo. Simply by enlisting the services of a moving company for your move you have the ability to prevent all this trouble. No have to worry about mismatched boxes, lifting, loading and also unloading all the boxes. This is without a doubt simply because you got a crew. Our movers will definitely see to it that pretty much every piece of furniture finds its proper location, and also each and every box resides in its matching room.
Quite possibly you have likely moved before or perhaps you are probably here on our page hoping to employ the services of a mover for the very first time; nevertheless lot of times if you're planning to move on your own can easily involve various trips. These trips are back and forth from the old apartment or house to the new one. Whether itis across the street, across town, state or even country, these trips consume a huge amount of time along with restrict your schedule. Simply by contracting a experienced company you save not only your precious time, but atthe same time your sanity. Moves may possibly be a serious worry factor especially when ever you are actually will have to travel to and fro from one location to the next. Moving companies are truly tasked with making the trips back and forth and not you. There purpose is really making your move as easy and hassle free as possible. By doing this you can do the things that you do and have the movers do their job.
This is among the main and is definitely not the least is very important to the moving experience. Moving Services come with all of the most appropriate tools. Your highly qualified mover will utilize hoisting straps, two wheel, 4 wheel or appliance carts, ramps and custom constructed trucks with air ride cushions to transport your possessions in a safe and secure manner. Hence even if it is simply moving an L-shaped couch outside of your door or taking apart your furniture, your hired band of help will figure it all out for you.
Moving any type of furniture can not really only be actually difficult, but likewise dangerous this is especially true when moving as well as lifting sizable furniture including: lounges, freezer or fridges, wine chilliers, washing and drying machines, recliner chairs and also a lot more. Supposing that you do not actually take particular measures to guarantee your safety regarding your own self whenever moving quite possibly the furnishings or even hefty appliances you could end up hurting yourself. Thankfully whenever hiring a Moving Services in Windward Circle you will not have to fret about any kind of injury for example, any kind of pulled or over used muscles given that you can leave it to the professionals to move your things to your next apartment or home. Doing this in addition eliminates the likelihood of you your own self tearing up a wall, running the risk of tearing a couch or getting any type of kind of physical ache.
Employing a skilled professional mover delivers extraordinary valuation at a time that can be typically quite hectic. Moving can possibly be both equally mentally along with on a physical level exhausting, as well as handling delicate or maybe bulky objects with care entails unique moving skills. Our staff really strongly recommend turning to service providers for this, because you would most likely with regard to most of your households needs which includes plumbing and electrical power. Among over One Decade of practical experience within local moving and long distance moving, our staffs of incredibly trained moving companies can easily undertake moves concerning pretty much any overall size and involvement. Our experts treat every single move by having the personal care that you would undoubtedly expect from family and friends. Having said that, as opposed to loved ones, our experts ensure full satisfaction.
Our team establish an estimation concerning a local area move at a hourly price, that includes the ride time for each and every stage of the move: coming from the moving company to your first house or apartment, and then to your desired destination, along with back once more to the moving company. Rates intended for a cross country move is usually based upon a fixed cost, fixed price. After we have certainly taken a stock of your furnishings and other possessions, and determined a timeframe for delivery, our company are happy to give a binding cost when it comes to your move. In case you would prefer, our experts are able to also price a cross country move by weight.
Moving labor costs represents the majority of the moving expense. That being said, you need to also budget for packing materials, which includes moving boxes as well as tape, and for additional valuation (moving insurance coverage) as needed. Al's takes particular precautions with breakable as well as extra-large possessions, which includes flat screen tv sets and also chandeliers. All these things typically demand a customized wooden crate, which will sustain an additional expense.
Along with more than 50 (combined) yrs of experience, our sales staff congratulates themselves with regards to ensuring one of the most accurate moving price quotes in the industry. Our proprietary sales system makes sure that our company work thoroughly with every individual that one may thoroughly comprehend his/her moving needs and to supply a moving quote which reflects those requirements. Be sure to supply as much info as possible at the time pertaining to the estimate - this includes evaluating the inventory for accuracy. Neglecting to point out additional objects, as well as complicated areas of access, during the time for the moving quote almost always produces unexpected costs for you the customer.
As with some other professional service industries, one may well wish to give thanks to your movers with regard to a job very well done with giving a gratuity. Although the movers do not expect a set amount, we recommend a tip formed on your full satisfaction with your crew and the overall relocation; using a broad rule of $4-6 for every guy, per an hour. In the case that you really feel that your movers went above and also beyond when it comes to their efforts, you might possibly desire to boost the amount as necessary.
Even though #brand: t # will definitely take virtually every vital preventative measure concerning your move, unanticipated damages may happen but it is vital making sure that your belongings are definitely secured. Our people have the ability to supply valuation moving insurance plans to our customers at an extremely reasonable rate as a result of the extremely low number of claims our company file.
Our staff recommend reserving your move as far ahead of time as you are able to. The longer out you can possibly plan your move, the better the availability you are going to have in picking a date and time in which is really convenient for you. An overall guideline is simply to consult with our company no later than 2 weeks in advance of your wished for move day. Our experts recognize advance preparation is simply not necessarily always possible, plus do our absolute best to accommodate last minute customers as well.
Concentrate on packaging, instead of moving. Smaller sized things and moving packages are moved extremely quickly by expert movers. Really don't invest time attempting to move these things yourself. Instead, work on packing boxes, so that whenever the movers arrive, you are without a doubt 100% ready. For additional information on packing and packing supplies check out our blog.
Certainly! #brand: t # supplies complete service storage space facilities as well as our high quality moving services. Assuming that your things do not actually fit in your new house or apartment, however you are actually only living there merely for a limited period of time and then have plans to move to an even bigger house alternatively you want to hold on to the items for family and friends, use of our storage space facilities is without a doubt a hassle-free, safe solution. Consult your move coordinator with respect to more detailed information concerning this service.
Select a helpful labeling solution (i.e. MBR for Master Bedroom) and see to it that that all of your boxes are simply clearly indicated. Boxes should certainly be tagged on the top together with 3 sides. Your movers are going to work tightly along with you for the destination to make sure everything winds up exactly where you really want it.
When the cabinets are generally made of metal or plastic, 2-drawer filing cabinets may possibly be left full. The top 2 drawers of a 4-drawer cabinet need to be normally emptied. All of lateral file cabinets need to be completely emptied. All drawers need to be emptied in wooden cabinets.
This is really generally fine to leave your clothes within your dresser drawers throughout the move. Don't forget to take away everything from the drawers that may roll about or perhaps move during the course of transport, considering that this may bring about damage. In the case that the dresser is possibly primarily large (a triple dresser or part of a large wardrobe), this is certainly best to at least somewhat empty it
You will make certain that your dishwasher, microwave oven, fridge, washing machine, and also clothes dryer are truly empty. Furthermore, movers are not trained electrical experts or plumbing technicians - you must arrange for the correct expert to detach your washer, lighting/chandeliers, and also fridge from any sort of electrical and/or water connectivity. Most significantly, movers are truly not actually certified to cut off natural gas, in which power lots of clothes dryers as well as ovens.
These types of possessions can be carried on local moves if effectively packed/prepared, however, our people may not promise the safe transporting for live plants, that may possibly be traumatized simply by motion or even ambient temperature extremes within the moving vehicle. We can not transport live plants regarding cross country moves.
#brand: t #, in addition to almost all Licensed Movers, will not move harmful or combustible objects for instance propane storage tanks, firearms, paint, and aerosols, considering that the temperature level in the vehicle could possibly trigger these particular items to explode or perhaps ignite.
When the movers first arrive, they will certainly conduct a walk through along with you of your current home, confirming which possessions are actually going and which are definitely not.
In the case that your moving day is swiftly approaching and also it ends up being apparent that you will not really be totally packed, it is vital that you notify your move organizer as soon as possible. He/she can easily consult with you to ensure the most efficient conceivable "plan b" with respect to packing. This may possibly mean having the movers complete your packing or even, in the event that you have the flexibility as well as we have the availability, moving back your moving day in order to make it possible for additional time to pack. In the event that you have a just a tiny quantity of items left to pack, your movers are able to often accomplish this on moving day; nevertheless, it is important to be aware of that this will certainly add time to the project and, because of this, add to the total fee of the move.
Certainly. When our team deliver your belongings to your new house the movers are going to work very closely alongside you to make sure all of furniture and also boxes arrive in the correct rooms, and we more than happy to arrange and rework the furniture just exactly as you would certainly like it.
With respect to your personal peace of mind, you may well want to consider moving precious jewelry as well as other small prized possessions yourself in your own personal vehicle. As for larger items - for example, fine art, antiques, musical instruments, unique collections, or even other items of great personal significance and worth - point these items out to your movers at the beginning of moving day so that these guys can easily take the required measures to make sure for their suitable care.
On moving day, you need to let the skilled professional movers handle the job entirely - these professionals are truly very trained and the absolute best suited to carry the heaviness as well as negotiate the loading of the truck. Generally speaking, having non-professionals perform along with the movers slows things down as well as costs you more ultimately. Your friends and family are able to be probably most very helpful in getting ready for the move - packing moving boxes or maybe caring for your family pets or children.
The fact is, currently there is actually zero safe place throughout the moving truck intended for family pets to ride. They can not be transferred within the cab of the moving truck for liability reasons and the rear of the moving vehicle is certainly inappropriate due to lack of environmental control and the possible danger caused by potential shifting of bulky objects.
Regretfully, skilled professional moving companies can in no way transport customers in the moving truck for liability factors. You may possibly choose to prepare a ride by having a friend or perhaps a cab service on move day.
Without a doubt. Our qualified movers and even moving trucks are conditioned so as to move during rain, sleet, or possibly snow. These people arrive outfitted with materials so as to help keep your personal belongings protected from the elements. On the other hand, so as to keep costs down, we recommend that you scoop, rake, or otherwise clear away the access ways in preparation for their arrival.
Feel free to contact us using our quote form.
Moving Services Windward Circle, LA
Moving Services Windward Circle, LA


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Four San Antonio Restaurants for Under $20
What better way to explore your new city while your local San Antonio movers finish unloading all of your belongings, than by checking out some of the most delicious food that the city has to offer? Since San Antonio has so many delicious restaurants, chances are that you will not want to stop with just one. Luckily, you can try as many restaurants as possible all summer long – without breaking the bank. Not only are San Antonio restaurants delicious, but there are plenty you can explore for $20 or less! Just sit back, relax and let All My Sons Moving & Storage do the work while you and your family enjoy these four San Antonio restaurants for under $20.
Café Bahar
Specializing in Indian and Halal Pakistani cuisine, get ready to try all of the spices of India – literally. A fantastic choice for those foodies with the motto "the spicier the better," Café Bahar has entrees that are $20 or less. The best part? This San Antonio restaurant allows you to bring in your own beer or wine without a corkage fee. Cheers!
The Esquire Tavern
Founded in 1933 to celebrate the end of Prohibition, The Esquire Tavern has been a beloved San Antonio bar ever since. San Antonio movers suggest that you try everything from delicious grilled pork loin to chile relleno, with one of their specialty cocktails without having to worry about spending too much – most of their offerings on the menu won't cost you over $20.
Mr. and Mrs. G's
If you are moving to San Antonio and looking for delicious soul food, then look no further. Mr. and Mrs. G's knows a thing or two about cooking up some classic fried chicken, mac and cheese and sweet potatoes. With an array of freshly made desserts, locals who have tried the sweet potato pie have said that it "must have been baked in heaven." With a review like that, chances are you will want to take your $20 and return for some down home cookin', time after time.
Rocotos Grill
A favorite family-owned spot, San Antonio moving companies have recommended this Peruvian restaurant for years and it is not hard to tell why. For less than $20, indulge in an order of ceviche, roast chicken called pollo a la brasa, or the lomo saltado, which is marinated beef strips that are stir-fried with sliced onions, red peppers and French fries and served with white rice. If you have never tried Peruvian cuisine, now is the time to dive right in!


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Join host Laura Maracle for discussions about Indigenous and women's issues.
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Susan Weech commented 2018-05-11 22:12:05 -0400I just downloaded your free CFRC radio app this afternoon so that I can hear Laura's inspiring talks. I thourally enjoyed the first show and am looking very forward to tomorrows show on mothers! Well done Laura!! Miigwetch p.s. I did the homework!! 😊


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Christopher's Caterpillars Tickets
Written and illustrated by Charlotte Middleton and adapted for the stage by Claire Alizon Hills, Topsy Turvy Theatre return with everyones favourite guinea pig in his latest adventure - Christopher's Caterpillars.
Christopher Nibble and his best friend Posie have been busy growing plants and food in their garden whilst taking care of their six hairy pet caterpillars.
But when their crawly comrades disappear without a trace the gardening guinea pigs swap their trowels for magnifying glasses and turn detective!
Will Christopher & Posie crack the case and bring their caterpillars home to Dandeville... or have they vanished forever?
Written especially for children aged 2-7 (and their big people too) and told with Topsy Turvy Theatre's own blend of energetic storytelling, handmade puppets, original music and stunning scenery, Christopher's Caterpillars is a bright and beautiful tale of minibeasts and mystery!
"Topsy Turvy Theatre have turned Christopher Nibble into magical life in this entertaining, humorous theatre show. The home town of Dandeville, is a beautifully crafted stage set, with patchwork hills, a miniature café , a library and plenty of delicious dandelion leaves . There's music, dancing and singing for all. My daughter (age 4) was very keen to watch two consecutive shows! I couldn't be more delighted with the adaptation of my story." - Charlotte Middleton
60 mins, no interval.
2- 7 years.
Christopher's Caterpillars Dates & Tickets
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spines has connected 53 ideas and 13 materials about
Good note-taking is at the heart of learning. We all tend to do it our way, without thinking too much about it, but you can improve your note-taking abilities substantially by learning about some efficient techniques, widely used.
Feel free to pick and choose the one that suits you better or to combine different aspects of several ones to build your own technique.
Richard Feynman - Wikipedia, the free encyclopedia
Named after famous physicist Richard Feynman, this simple but effective technique consists in explaining to yourself what you want to learn.
Write an explanation of the subject as if you were trying to teach it to someone else. Explaining the idea in this way reveals what parts you really understand and which ones you don't know so well. If you are struggling to lay down a clear, complete explanation, possibly you need to study it again.
Anytime you are stuck, go back to the source material and read again that part until you understand it well enough to explain it on paper.
You should be using your own words for the explanation, not merely copying the sentences you have just read. Write in simple words so that anybody could read about it. If your explanation is not clear and complete, it may be an indication that your understanding of the idea is not that good. Simplify the lenguage or use an analogy to clarify the explanation.
Note Taking Systems - Academic Skills Center: Study Skills Library - Cal Poly, San Luis Obispo
This technique is surely the one most people resort to when taking notes in a hurry. The important aspect of this method is the deliberate organization of the space, and the work that comes immediately after a note-taking session.
Try to summarize without missing information and go straight to the point. Ensure that you know where every idea starts and ends.
Leave a blank space every time you need one. Either there's something you missed but will fill in later, or there are ideas that will require further explanation. It's better to err on the side of too much space left.
Outline note taking method 2-2
How to take Cornell notes - YouTube
Invented by Walter Pauk, it's designed to reduce the amount of time you spend processing your notes after class before you elaborate on them.
With your paper divided in three distinct areas, write short sentences in the note-taking column to record the most important ideas of a lecture.
After the lecture, formulate questions in the cue column based on your notes. Writing questions helps to clarify meanings, reveal relationships, establish continuity, and strengthen memory. Also, the writing of questions sets up a perfect stage for studying later.
In the next 24 hours, write a brief summary in the bottom area of the page. This helps to increase understanding of the topic. Now you have a concise but detailed and relevant record of previous classes.
how I mind map - YouTube
Ideas are written in a tree structure, with lines connecting them together from a central point, purpose or goal in the center of the page and then branching outward to identify all the ideas connected to that goal.
A mind map is a diagram used to visually organize information. A mind map is often created around a single concept, drawn as an image in the center of a blank landscape page, to which associated representations of ideas such as images, words and parts of words are added. Major ideas are connected directly to the central concept, and other ideas branch out from those.
Learn More, Study Less – Flow-Based Notetaking
The primary goal of the Flow Method is to improve the amount of #information you assimilate and learn while note-taking.
Organize information spatially, with arrows connecting ideas. Be sure to capture the most important ideas in your own words, and omit or downplay the irrelevant. If you can't describe something in alternate terms, you probably don't adequately understand the original terms. Your goal is not the transcription: it's learning while you are note-taking.
Transcribe information in a completely different way from its presentation. Use your own words to create a new set of ideas and understandings. Flow-based notetaking is a creative process, not a recording method. You should come up with your own ideas, examples and connections.
The Fantastic Mr Feynman - YouTube
Named after famous physicist Richard Feynman, this simple but effective technique consists in explaining to yourself what you want to learn.
Pretend you're teaching the concept to someone else.
Write an explanation of the subject as if you were trying to teach it to someone else. Explaining the idea in this way reveals what parts you really understand and which ones you don't know so well. If you are struggling to lay down a clear, complete explanation, possibly you need to study it again.
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If you're having trouble seeing the examples, you can also download them here: http://www.scotthyoung.com/mit/801-notes.pdf The technique is inspired by Richard Feynman and the story I share at the beginning which is taken from his autobiography, Surely You Must Be Joking, Mr. Feynman.
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Study Skills Library: Note Taking Systems
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A helpful tutorial on how to take Cornell notes. This explains why you should take them and how.
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Hi! Hope you all find this video helpful :) ----------------------------------------------------------- ●school supplies haul https://youtu.be/OsDEXxifX8Q ...
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"Richard Feynman is one of the most iconic, influential and inspiring scientists of the 20th century. He helped design the atomic bomb, solved the mystery of...


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Clubs are probably the oldest and most widely used of all offensive weapons. Although most commonly carved from wood, clubs can be made with stone, bone and metal. They vary from small and surprisingly light to massive two-handed forms. Although some clubs are very simple in shape, many show design features that are stylistic rather than functional. These clubs tend to be embellished with designs that express the status and preferences of the individual owner. Only rarely do they display ornamentation with symbolic or public display functions.
With the advent of metal, many cultures stopped using clubs in warfare, some preferring maces with metal heads instead. However in Oceania, where club warfare was especially common, these exquisitely carved and decorated weapons were widely used well into recent times.


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The Steelers won the Super Bowl!
Let's celebrate by having pierogies for supper tonight, shall we? Try one of the following methods to prepare your pierogies, or leave a new method or recipe in the comments below.
Traditional Pierogies with Butter and Onions
Spicy Pierogies
- 1 box pierogies any flavor
- 2 tablespoons olive oil
- 2 tablespoons fresh parsley chopped
- 1 tablespoon fresh basil chopped
- 2 cloves garlic pressed
- 1 teaspoon paprika to taste
- 1/2 teaspoon cayenne pepper to taste
- Boil the pierogies according to package directions.
- Toss hot pierogies with olive oil, parsley, basil, and garlic.
- Sprinkle pierogies with paprika and cayenne pepper, to taste.
Pierogies Alfredo
- 1 box pierogies any flavor
- 2 cups ham pre-cooked and cubed
- 2 cups broccoli florets chopped
- 1 cup cherry tomatoes
- 26 ounces commercial Alfredo sauce commercial cheese sauce would also work
- bread crumbs
- Preheat oven to 350.
- Toss the frozen pierogies with pre-cooked ham cubes, broccoli florets, and cherry tomatoes in a 9x13 baking dish.
- Pour alfredo or cheese sauce over other ingredients. Stir.
- Top with bread crumbs.
- Bake for 30 to 40 minutes.
© 2009 – 2017, Tara Ziegmont. All rights reserved.


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Bánh trôi Tàu ("Chinese floating cake") is a dessert that originated from China, consisting of balls made from mung bean paste and sesame wrapped in a shell of glutinous rice flour. The balls are served in a hot, sweet and dilute saurce made of water, sugar, grated ginger root, sesame seeds and grated coconut. Bánh trôi Tàu is similar to Bánh trôi nước.


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Arksafe will work with you to conduct health and safety audits and inspections to make the workplace safer, healthier and more efficient.
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With careful forward planning, and active day to day management, Arksafe projects are run with health and safety as a top priority.
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