Title. Diarylureas as CB1 Allosteric Modulators Patent Application Number. WO 2018/209030 A1 Publication Date. November 15, 2018 Priority Application. US 62/505,383 Priority Date. May 12, 2017 Inventors. Zhang, Y.; Nguyen, T.; German, N. Assignee Company. RTI International. Disease Area. Cardiovascular and Metabolic Diseases Biological Target. CB1 Receptor Summary. The endocannabinoid system (ECS) consists of two well characterized receptor subtypes, the cannabinoid receptor 1 (CB1) and the cannabinoid receptor 2 (CB2). They are endogenous lipid-based retrograde neurotransmitters that binds to cannabinoid receptors and are activated by the psychoactive component of marijuana (Cannabis sativa) Δ-tetrahydrocannabinol (THC). In addition, both receptors belong to a class 1A rhodopsin-like cell membrane receptors in the G protein-coupled receptor (GPCR) superfamily. There are growing evidence that the ECS is involved in a number of physiological processes and pathologies, including cancer, metabolic and eating disorders, neurodegeneration, locomotion, pain, liver disease, and immunosuppression. Thus, the ECS provide excellent options for the development of new drugs. The CB1 receptors are one of the most abundant GPCRs expressed in the central nervous system and are also present at much lower concentrations in the spleen, tonsil, arteries, bone marrow, lungs, heart, and so forth. They attenuate a wide variety of physiological functions such as cardiovascular, respiratory, metabolism, neuronal development, cell proliferation, and apoptosis. Upon activation, the CB1 receptor primarily couples to Gi/o-type G proteins, which leads to downstream inhibition of adenylyl-cyclase and reduces cAMP levels in cells. Furthermore, CB1 receptor can negatively couple to Nand P/Q-type voltage-gated Ca channels and positively couple to A-type and inwardly rectifying K channels. Because of its complex signaling network, CB1 has been demonstrated as a viable target in the pathology of many disorders and thus is a promising therapeutic target for ameliorating diseases including drug addition, multiple sclerosis, psychosis, nausea, obesity, neurodegenerative disorders, pain, gastrointestinal diseases, and inflammation. Consequently, extensive efforts have been invested to generate cannabinoid-based therapeutics; however, only a few medications from cannabinergic compounds are commercially available due to the extensive side effects associated with CB1 orthosteric ligands. For example, rimonabant, a CB1 ligand, which was initially developed for obesity, was withdrawn from the market due to risk of suicidal ideation and psychiatric side effects. In addition, licensed cannabinoid medications that contain THC are prescribed with many restrictions due to the possibility of psychoactivity and additive tendency. However, the CB2 receptor is found mainly in immune cells and modulate cytokine release and immune cell migration. The CB2 receptor has similarity in amino acid sequence to the CB1 receptor, and its discovery helped explained the pharmacological properties of tetrahydrocannabinol and the effects of cannabinoids on the immune system. CB2 receptors inhibit the activity of adenylyl cyclase through their Gi/Goα subunits and are also known to couple to the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway (MAPK-ERK pathway). Selective CB2 agonists are therapeutics for treatment of CB2-receptor expressing malignant gliomas, multiple sclerosis, tumors of immune origin, osteoporosis, and so forth. Growing evidence suggests that the CB1 receptor exists in multiple active conformations, each of which may display an alternate approach in regulating unique signaling pathways. Recently, several small molecules have been identified as allosteric modulators of the CB1 receptor that bind to distinct binding sites from the orthosteric site. Compared to orthosteric ligands, allosteric modulators offer many therapeutic advantages, such as minimal evolutionary burden, and allosteric binding pockets have amino acid sequences that are not highly conserved and may be more specific for each receptor subtype. In addition, allosteric modulators have a ceiling effect due to their limited allosteric cooperativity, which can be used to generate titrated pharmacological responses and also to fine-tune endogenous signaling without affecting the spatial and temporal aspects of endogenous signaling. Furthermore, the different receptor conformation states induced by allosteric modulators can be biased for coupling to different G proteins or β-arrestin. Thus, these attributes can impact intracellular signaling pathways and offer promising avenues to develop subtype-specific and pathway-specific therapeutics. Examples of allosteric modulators that have advanced to the market, include Cinacalcet, a positive allosteric modulator (PAM), and Maraviroc, a negative allosteric modulator (NAM). The compounds of this Patent Highlight are novel cannabinoid CB1 receptor allosteric modulators that can be useful in the treatment of diseases and conditions caused by physiological processes implicating the cannabinoid CB1 receptor. These include drug dependence, learning disorder, pain regulation, appetite control, cardiovascular regulation, and memory and metabolic syndromes.


The history of tribal-state conflict and the role of the federal government is nearly two centuries old. In recent years, the most contentious source of conflict between American Indian tribes and states has been Indian gaming. The Congress attempted to compromise and resolve the issue by passing the Indian Gaming Regulatory Act (IGRA) in 1988, but the law has only exacerbated and opened up new avenues of conflict. The scope and stakes of Indian gaming can be seen in the history of Indian gaming in New Mexico where the defects in IGRA have been readily apparent. As Indian gaming has grown, so have efforts to curtail it and other aspects of tribal sovereignty, including tribal sovereign immunity. These efforts are currently underway in the Congress. Intergovernmental relations involve relationships of power between and among sovereigns. The study of federalism and intergovernmental relations has traditionally focused on the power relationships between the federal and state governments and between state and local governments. There is, however, another set of power relationships existing in American federalism often overlooked by scholars, if not by practitioners. More than 300 federally recognized American Indian tribes in the lower 48 states exercise government powers that increasingly put them in positions of conflict and cooperation with state governments. Overall, the history of tribal-state relations has tended to be one of conflict rather than partnership. Daniel McCool has noted, "One of the most divisive intergovernmental conflicts in the history of the United States has occurred between state governments and Indian tribes."' Others have written: One of the clearest and most persistent themes involving Indian sovereignty has been the continuous struggle by the states to assert greater control over Indian reservations, either at the expense of the federal or tribal governments. The pace of the struggle, the form that it takes, and the forum in which the struggle occurs have changed over time.2


Touristic destinations all around the world are struggling to digitally transform the touristic experience and the touristic products they offer and to capitalize a good experience with new tourists and returning ones. There is a lot of research on digital solutions assisting tourism, but it does not provide a follow-up digital product, therefore depending only on physical gifts, postcards and mementos. In this work, we propose a novel platform that can provide a personalized digital memento or digital gift for every route or tourist destination that can become the digital point of reference of visitors' experience giving new dimensions for commercialization to the existing physical mementos at the gift shops. The purpose of this study is to analyze what comprises a memorable touristic experience and to design and, finally, present a total solution that builds and offers a personal e-souvenir of a touristic experience to the tourist for him to hold, sport and share just using his mobile phone. We propose a digital memento-building platform that includes the personalized experience in visits taking place while in vacations. The visitors are usually taking pictures along routes they follow that later need further organization and processing and that in no way substitutes the physical mementos. In our approach, we propose a solution that generates a unique and personalized e-souvenir through a collage of the selfies and photos creating the digital equivalent of the touristic postcards but in our case personalized with the visitor photos with minimum amount of effort and produced real-time. Our approach is also providing a platform to the photographers and designers of touristic destinations to build and graphically generated memento artifacts—templates specific for one or more destinations or routes. In this way, the approach serves the tourism industry vertically, covering all aspects, i.e., the tourist-visitor, the tourism professional players such as photographers, designers of physical mementos and, of course, the touristic destination providing a digital footprint to server marketing of the destination through sharing on social media and word-of-mouth, of course. To support our approach, we have built and run a fully working prototype in the touristic center of Athens, Greece, with real users and designers for several weeks during summer vacations. The results have been greatly encouraging from end-users and professionals. The study shows that it is possible for various lines of business to come together and work along one another for an improve touristic experience using mobile technologies in a personalized, targeted approach. The touristic destination, graphic designers, photographers, tourist agent specialists, software developers and visitors can all now have a digital personalized memorable gift from the visit.


For a set U (the universe), retrieval is the following problem. Given a finite subset S ⊆ U of size m and f : S → {0, 1} for a small constant r, build a data structure Df with the property that for a suitable query algorithm query we have query(Df , x) = f(x) for all x ∈ S. For x ∈ U \ S the value query(Df , x) is arbitrary in {0, 1}. The number of bits needed for Df should be (1 + ε)rm with overhead ε = ε(m) ≥ 0 as small as possible, while the query time should be small. Of course, the time for constructing Df is relevant as well. We assume fully random hash functions on U with constant evaluation time are available. It is known that with ε ≈ 0.09 one can achieve linear construction time and constant query time, and with overhead εk ≈ e−k it is possible to have O(k) query time and O(m1+α) construction time, for arbitrary α > 0. Furthermore, a theoretical construction with ε = O((log logm)/ √ logm) gives constant query time and linear construction time. Known constructions avoiding all overhead, except for a seed value of size O(log logm), require logarithmic query time. In this paper, we present a method for treating the retrieval problem with overhead ε = O((logm)/m), which corresponds to O(1) extra memory words (O(logm) bits), and an extremely simple, constant-time query operation. The price to pay is a construction time of O(m2). We employ the usual framework for retrieval data structures, where construction is effected by solving a sparse linear system of equations over the 2-element field F2 and a query is effected by a dot product calculation. Our main technical contribution is the design and analysis of a new and natural family of sparse random linear systems with m equations and (1 + ε)m variables, which combines good locality properties with high probability of having full rank. Paying a larger overhead of ε = O((logm)/m), the construction time can be reduced to O(m1+α) for arbitrary constant 0 < α < 1. In combination with an adaptation of known techniques for solving sparse linear systems of equations, our approach leads to a highly practical algorithm for retrieval. In a particular benchmark with m = 107 we achieve an order-of-magnitude improvement over previous techniques with ε = 0.24% instead of the previously best result of ε ≈ 3%, with better query time and no significant sacrifices in construction time. 2012 ACM Subject Classification Theory of computation → Data structures design and analysis


Speculative currency attacks are a regular feature of the international political economy. Nevertheless, not all speculative attacks result in a devalued currency. In many cases, politicians were willing and able to defend the exchange rate peg. I develop a model of strategic interaction between speculators in currency markets and policymakers in governments. This model indicates that speculative attacks occur when economic fundamentals are weak or when there is uncertainty about the capability and/or willingness of governments to defend the currency peg. I show that the government's decision to defend the peg reflects institutional, electoral, and partisan incentives. I test hypotheses from this model on a sample of 90 developing countries between 1985 and 1998 using a strategic probit model.


A number of conserved features or characteristics have been identified in the EEV NS3 protein in the preceding chapter, and similar features have previously been identified in other orbivirus NS3 proteins . In order to further study and characterize EEV NS3, specifically regarding the relationship between structure and function, it is therefore necessary to express the protein and to study its expression .


Described is a method of producing p-doped layers, particularly in II-VI semiconductors, wherein the p-doped layer is produced in a CDV process using plasma activation of nitrogen-containing gases.


This thesis is a study about the most significant philosophical writings on death penalty under the Enlightment period. Our main purpose is not to present the pros and cons on such a matter but to examine the possibility to give a rational foundation to a categorical condemnation of death penalty. Our aim is to determine wether one should understand the distance between opponents and supporters of such a punishment as a gap between rationality and passion or sensitivity. It is striking to notice that both sides tend to qualify their opponent's position as irrational. On one hand, those in favour of capital punishment are usually considered as blinded by a strong desire of revenge; on the other hand, abolitionists are accused of betraying justice because of their compassion toward criminals. But is the answer to the question of death penalty a matter of pure rationality? By studying the writings of those who opposed it (Beccaria, Bentham, Fichte) and those who supported it (Kant and John Stuart Mill), we came to the conclusion that it is totally hopeless to expect our reason alone to put an end to this debate. In reality, human reason is able to produce different conclusions depending on the premises we choose to consider as right. Our second conclusion is that it is even impossible to say that retributivism and utilitarianism in themselves support or oppose death penalty. Different versions and interpretations of these two theories lead their defenders to different positions. Finally we found in Jean-Jacques Rousseau's works some decisive elements in order to argue against death penalty without ending into dogmatic rationalism nor pure emotivism.


ABSTRACT Purpose: Nuclear cataract is the most common subtype of age-related cataract, the leading cause of blindness worldwide. It results from advanced nuclear sclerosis, or opacity in the center of the optic lens, and is affected by both genetic and environmental risk factors, including smoking. We sought to understand the genetic factors associated with nuclear sclerosis through interrogation of rare and low frequency coding variants using exome array data. Methods: We analyzed Illumina Human Exome Array data for 1,488 participants of European ancestry in the Beaver Dam Eye Study who were without cataract surgery for association with nuclear sclerosis grade, controlling for age and sex. We performed single-variant regression analysis for 32,138 variants with minor allele frequency (MAF) ≥0.003. In addition, gene-based analysis of 11,844 genes containing at least two variants with MAF < 0.05 was performed using a gene-based unified burden and non-burden sequence kernel association test (SKAT-O). Additionally, both single-variant and gene-based analyses were analyzed stratified by smoking status. Results: No single-variant test was statistically significant after Bonferroni correction (p < 1.6 × 10–6; top single nucleotide polymorphism (SNP): rs144458991, p = 2.83 × 10–5). Gene-based tests were suggestively associated with the gene RNF149 overall (p = 8.29 × 10–6) and among never smokers (N = 790, p = 2.67 × 10–6). Conclusions: This study did not find a significant genetic association with nuclear sclerosis, the possible association with the RNF149 gene highlights a potential candidate gene for future studies that aim to understand the genetic architecture of nuclear sclerosis.


ABSTRACT: Thirty‐nine patients with cutaneous leishmaniasis caused by Leishmania major were treated with rifampicin alone or in combination with isoniazid. No significant difference was found between these two therapeutic regimens, and about half of the patients were cured 2 months from the beginning of treatment. A review of rifampicin in cutaneous leishmaniasis is attached.


The aim of present work is to develop and validate spectrophotometric methods for the determination of fenofibrate, an anti-hyperlipidemic, fibric acid derivative in pharmaceutical formulation. Methanol was used as a solvent throughout the study. Quantitative determination of fenofibrate in pharmaceutical formulation was carried out by UV-spectrophotometric method using the absorbtivity values at 287.5 nm and by comparison with standard (method 1a and 1b) and the first order derivative absorbance values at 249.2 nm were utilized for estimation of drug (method 2). The method showed high specificity in the presence of formulation excipients and good linearity in the concentration range of 0-60 μg/mL. Percent recovery values at 287.5 nm were 100.3% while it was 100.18% at in 1st order derivative spectrophotometry at 249.2 nm (n=3). SD values showed that both spectrophotometric methods were reproducible. The intra and interday precision data demonstrated that method is precise.


TPS2612 Background: Loss of the metabolic tumor suppressor, argininosuccinate synthetase (ASS1), a rate-limiting enzyme in arginine biosynthesis, sensitizes mesothelioma and lung carcinoma cells to apoptosis following arginine withdrawal. Recently, we showed potentiation of the cytotoxic effect of pemetrexed by the arginine depletor pegylated arginine deiminase (ADI-PEG 20) in ASS1-negative tumor cells, which was accompanied by suppression of de novo pyrimidine synthesis and the pyrimidine salvage pathway (Allen et al, Cancer Res 2014). Consequently, we have initiated a phase I study (NCT02029690) to assess the maximum tolerated dose (MTD), safety and toxicity, and preliminary efficacy of ADI-PEG 20 combined with first-line pemetrexed and cisplatin chemotherapy in patients with ASS1-deficient mesothelioma or non-squamous non-small cell lung cancer (NSCLC). Methods: Up to 47 good performance (ECOG 0-1) patients are being enrolled in a 3+3+3 phase 1 design using tumoral ASS1 loss as a selection biomarker. W...


THE ADMINISTRATION of development in developing countries is effected primarily through politicians and the civil service operating, more or less, within a ministerial system or government agency and characterised by its purposes, its loyalties, and its attitudes. The purposes of development administration are to stimulate and facilitate defined programmes of social and economic progress or, put another way, development administration is the administration of policies, programmes, and projects to serve development purposes. This term is used to denote the complex of agencies, management systems, and processes a government establishes to achieve its development goals.


The volcanic rocks of the Aguacate Group located at S and SW of the "Cordille-ra de Tilaran" represent an orogenic family principally composed by members of the tholeiitic series and a few of the calc-alkaline series (sensu MIYASHIRO 1974). The main volcanic rocks of this Group are: uartz-latiandesite, latiandesite, andesite and tuffite. Three types of wall rock alteration can be found in these rocks: 1. Strong propylitization in direct relation to pyrite fractures and in rocks in which the clay phases chlorite, beidellite, kaolinite and illite have been developed; 2. Intermediate to advanced argillic alteration with the subzones: a) kaolinite, b) kaolinite, alunite, e) kaolinite, pyrophyllite d) beidellite, illite/beidellite; e) kaolinite, cristobalite; 3. Incipient sericitic alteration with quartz and pyrite. 25%. Probably alunite is formed by the reaction of sulfuric acid with illite: KA13Si3010(OH)2 + 4H + 2504 KA13(304)2(OH) + 35i02 The theoretical standard free energy of chis reaetion is -42.0 Kcal/mol by The limits between the different types of alterations are not elearly defined. Secondary minerals e.g. chlorite, disordered kaolinite (fire clay) and beide-Ilite are also formed by reasons of weathering in zones which are not affected by hidrothermal alteration.


OAK RIDGE NATIONAL Laboratory's production and distribution of radioisotopes for peacetime uses was designated an ACS National Historic Chemical Landmark at a ceremony at the Tennessee facility on March 6. About 150 ORNL staff, retirees, and guests were on hand as ACS President Bruce E. Bursten presented a commemorative plaque to Thomas Mason, director of the lab. Bursten said the laboratory's distribution of radioisotopes, which began in 1946, "demonstrated the peaceful uses of nuclear energy, providing medical, scientific, and industrial benefits to society." The society's National Historic Chemical Landmarks program started 15 years ago to help chemists recognize and celebrate the profession's rich history. "The 60 landmarks that we have designated so far demonstrate how chemists have expanded the frontiers of knowledge, developed lifesaving drugs, advanced industry, and created new products," Bursten said. Among the landmarks that have been honored are development of Bakelite, the first synthetic plas...


To clarify whether the dissemination of Pneumocystis carinii(PCP) occurs in the extrapulmonary tissues and organs(kidney,liver,spleen and bone marrow),the PCP rat model was established by intramuscular injections of the Wistar rats with dexamethasone for 10 weeks,and the etiological and pathological examinations were performed on the tissue sections taken from various organs of the PCP rat and the normal rats were taken as controls.It was found that the positive rates of PCP cysts in smears of lungs,kindney,liver,spleen and bone marrow of PCP rat were 100%(25/25),4%(1/25),0%(0/25),0%(0/25),0%(0/25) respectinely.No PCP cyst could be demonstrated in smears taken from normal rats.However,there were marked pathological changes in smears of lungs taken from PCP rats,characterized with typical interstitial pneumonia,but no pathological changes could be detected in the extra pulmonary organs without any difference with the normal controls.These results suggest that no extra pulmonary dissemination exists in Pneumocystis carinii rat model.


A recent case of an employment tribunal victory by two general nurses, who had to accept redundancy when compulsory rotational shifts were introduced by their trust, is an interesting one.


THE RN23 DIVERSION AT CHAMPTOLE (MAINE ET LOIRE) CROSSES 350M OF ALLUVIAL SOIL IN A VALLEY FILLED WITH APPROXIMATELY 10M OF COMPRESSIBLE SOIL. IT WAS PLANNED TO BUILD A 9M-HIGH EMBANKMENT OVER THE EXISTING BED. A RIVER WHICH FLOWS IN THE VALLEY, SHOULD HAVE BEEN DIVERTED TOWARDS THE LEFT BANK OF THE VALLEY AND SPANNED BY A STRUCTURE RESTING ON ROCKS. THE EMBANKMENT FAILED AT THE SITE OF THE OLD RIVER BED OVER A LENGTH OF 150M AND THE CONSTRUCTION WORK HAS TO BE STOPPED. DETAILS ARE GIVEN OF THE EMBANKMENT, SUBGRADE, SOIL MECHANICS STUDY CONDUCTED, CONSTRUCTION AND FAILURE OF THE EMBANKMENT, AND THE REPAIR WORK CARRIED OUT. THIS ARTICLE IS IN FRENCH.


We reported a healthy monitoring network based on Brillouin scattering in civil engineering. The long distance sensing problem is solved by series-wound Brillouin OTDR system. Sensing and communication is realized in one optic fiber through WDM. Fabric diagnose based on strain mode is used to analyze structure state. The real-time reliability and safety state of the structure can be evaluated through this network system.


We apply the stochastic master equations (quantum filter) derived by Gough et al. (Proc. 50th IEEE Conference on Decision and Control, 2011) to a system consisting of a cavity driven by a multimode single photon field. In particular, we analyse the conditional dynamics for the problem of cross phase modulation in a doubly resonant cavity. Through the exact integration of the stochastic equations, our results reveal features of the problem unavailable from previous models.


Pel-recursive motion estimation is a well established method for finding the displacement vector-field (DVF) between adjacent image frames. The motion due to the optical flow in image sequences is estimated recursively. In this paper, we improve the Wiener-based pel-recursive algorithm by using spatially-adaptive regularization. The outcome of the regularized solution is dependent upon the value of the regularization parameter. This work employs a data-driven approach called generalized cross-validation (GCV) to determine the optimal value of the regularization parameter for each pixel. Experimental results are presented and the linear minimum mean-squared (LMMSE) solution (also known as the Wiener solution) is compared to the proposed approach.


A 64-year-old woman presented with a subcapital fracture of the right femur after minimal trauma. She had been noted to have a goitre when aged 27 but had never had symptoms of thyrotoxicosis. On examination a goitre was palpable but there were no signs of thyrotoxicosis. Plasma calcium, phosphate, and creatinine concentrations and alkaline phosphatase activity were normal, but there was evidence of increased bone resorption with a high fasting urine hydroxyproline:creatinine ratio (0-06 molar units; normal <0 02). There was malabsorption of calcium (radiocalcium absorption 0-20 fraction of dose/hour; normal 0-3-1-4); low plasma 1,25-dihydroxy vitamin D concentration (64-2 pmol/l (25.7 pg/ml); normal 75-165 pmol/l (30-66 pg/ml)); and normal plasma 25-hydroxy vitamin D concentration (66-5 nmol/l (26-6 ng/ml); normal 42-5-215 nmol/l (1786 ng/ml)) and plasma parathyroid hormone concentration (345 pg/ml; normal 53-450). There was radiological evidence of cortical osteoporosis (metacarpal cortical area:total area 0-51; mean±SD for age-related normal women 0-75±0 06) and histological evidence of trabecular osteoporosis (iliac crest bone volume 9%; normal >15%,). Thyrotoxicosis was shown by a raised thyroxine concentration (157 nmol/l (12-2 ,ug/100 ml); normal 60-140 nmol/l (4-7-10-9 tg/100 ml)); triiodothyronine concentration (5 0 nmol/l (3 3 ng/ml); normal 1-6-3-0 nmol/l (1-0-2-0 ng/ml)); and free thyroxine index (4-6; normal 13-3-2). She was treated with carbimazole and was biochemically euthyroid after three weeks. Bone resorption as assessed by the urinary hydroxyproline:creatinine ratio took much longer to return to normal (figure).


We have read with attention the article entitled ''Migraine is a risk factor for sudden sensorineural hearing loss: A nationwide population-based study'' by Chu et al. (1). The authors have reported a welldesigned retrospective study in two cohorts of migraine and non-migrainous patients matching by age, sex and comorbidities such as diabetes, hypertension, dyslipidemia and atrial fibrillation. Although this matching has avoided a selection bias for vascular risk factors, the authors have not considered systemic autoimmune diseases, and they can be associated with sensorineural hearing loss. We have found a higher prevalence of rheumatoid arthritis, systemic lupus erythematous and ankylosing spondylitis in patients with Meniere's disease (MD) and migraine than in patients with MD and tension-type headache (2). Interestingly, the authors have excluded MD as a cause of sudden onset sensorineural hearing loss (SSNHL), but they have not considered vestibular migraine (VM). The reported incidence rate of MD seems too high when compared to published rates (227 MD patients of a total of 13,532 migraine patients during the 10-year follow-up). It should also be noted that about 50% of patients with MD meet criteria for migraine (3). It is our opinion that several of the excluded MD patients were probably VM sufferers, and some migraine patients with SSNHL may correspond to VM patients. VM is probably the most common cause of recurrent spontaneous vertigo (4). The relation between migraine and MD is well known. An increased prevalence of migraine in MD patients has been reported in several studies; likewise migraine may predispose to develop MD. Vestibular migraine and MD overlap in presentation and may be misdiagnosed. It has been proposed that both conditions share a common pathophysiology and may even be inherited as a symptom cluster. The diagnostic criteria of VM will be included in the appendix of the next review of the International Headache Classification. This will contribute to elucidating the differential diagnosis. Cochlear symptoms are also present in VM. Although phonophobia is the most common auditory symptom, 50% of VM patients refer tinnitus and 34% report hearing loss (5). Hearing loss is usually episodic in VM, but permanent unilateral hearing loss and SSNHL has also been reported in vestibular migraine. We suggest that autoimmune inner ear disease may explain the differences in SSNHL between both groups. Regardless, these comments do not decrease the merit of the study.


Purpose of review Labor is among the most painful experiences that humans encounter. Neuraxial analgesia is the most effective means of treating this pain. In this review, we discussed the effect of neuraxial analgesia on the progress of labor when compared with parenteral opioids. We then compared initiation of analgesia with a combined spinal–epidural technique (CSE) to conventional epidural analgesia. Finally we discussed the impact of neuraxial analgesia, given early in labor, compared with later administration. Recent findings Compared with parenteral opioids, neuraxial analgesia does not increase the incidence of cesarean section, although it is associated with a longer (∼16 min) second stage of labor. The incidence of operative vaginal delivery is higher in the epidural group but this may be due to indirect reasons such as changes in physician behavior. There was no difference in labor outcome when CSE was compared with low-concentration epidural analgesia, but higher concentrations may prolong labor. Early administration of neuraxial analgesia does not increase the incidence of operative delivery or prolong labor. Summary Neuraxial analgesia does not interfere with the progress or outcome of labor. There is no need to withhold neuraxial analgesia until the active stage of labor.


Diabetes is commonly associated with microvascular dysfunction. Our previous study found that microvessels of diabetic rats had increased basal permeability and enhanced permeability responses to inflammatory mediators. We also found that diabetic rats had increased circulating microparticles (MPs). MPs are small vesicles released by activated or apoptotic cells and carry multiple antigens from activated cells. We hypothesized that MPs serve as vectors to actively disseminate inflammation to the whole vascular system. We used flow cytometry to quantify the numbers of MPs and their cell origins. We tested differences between MPs generated by diabetic rats and MPs from normal rats by directly perfusing them into intact microvessels. The effects of MPs on microvessel walls were examined by perfusing matched numbers of isolated Annexin V positive MPs into normal venules for 30 min. After 10 min resumed blood flow in MP perfused vessel, we found significantly higher number of adherent leukocytes in diabetic MP perfused vessels than in normal MP perfused vessels. Diabetic and normal MP‐ mediated leukocyte adhesion were 17 ± 2.9 and 5.7 ± 0.5 leukocytes per 100 μm of vessel length, respectively. Flow cytometry analysis showed that diabetic MPs had an average 7‐fold increase in phosphatidylserine exposure per MP and a 12‐fold increase in platelet‐leukocyte MP aggregates from those in normal plasma MPs. Our results suggest that the population differences and the larger surface area of PS exposed diabetic MPs may contribute to the greater leukocyte adhesion induced by diabetic MPs. These results support our hypothesis that increased MPs in diabetic rats are more than simply biomarkers of the disease but that they are able to directly mediate leukocyte adhesion and actively disseminate inflammation to remote regions.


In this paper we present a realization of dark dimension. We consider the 5D standard model coupling to gravity with one dimension compactified on an orbifold, which is seen as dark dimension of size R. We stabilize the radion by casimir effect wrapping around compact dimension and recover the neutrino mass and 4D cosmological constant with the observed value. Orbifold can lead to a natural resolution of chirality problem in 5D at low energy, which we briefly discussed in the paper. Although we found that the radion mass is too light to survive under solar system tests of GR, several screening mechanisms might give us a solution, for example, Chameleon mechanism.


Structural distortion of ferroelectric thin films caused by film strain has a strong impact on the microwave dielectric properties. SrTiO3 thin films epitaxially grown on (110)DyScO3 substrates using molecular beam epitaxy are extremely strained (i.e., ∼1% in-plane tensional strain) from 3.905A of bulk SrTiO3. The room-temperature in-plane dielectric constant and its tuning of the films at 10GHz are observed to be 6000 and 75% with an electric field of 1V∕μm, respectively. The control of strain in SrTiO3 provides a basis for room-temperature tunable microwave applications by elevating its phase-transition peak to room temperature.Structural distortion of ferroelectric thin films caused by film strain has a strong impact on the microwave dielectric properties. SrTiO3 thin films epitaxially grown on (110)DyScO3 substrates using molecular beam epitaxy are extremely strained (i.e., ∼1% in-plane tensional strain) from 3.905A of bulk SrTiO3. The room-temperature in-plane dielectric constant and its tuning of the films at 10GHz are observed to be 6000 and 75% with an electric field of 1V∕μm, respectively. The control of strain in SrTiO3 provides a basis for room-temperature tunable microwave applications by elevating its phase-transition peak to room temperature.


The article explains the importance of personnel management and puts forward the current problems in it and the related solutions.


A field strain GD-1-12of chicken anemia virus(CAV)was isolated from a 12-day-old broiler flock with growth runting syndromes from Gongdong province.MDCC-MSB1cells were used to proliferate the virus of GD-1-12isolate.SPF chickens at 1day were challenged with the virus by intramuscular injection. Ratios of thymuses,spleens,livers,the bursas to body weight,and the CD3+T cells in thymuses and peripheral blood were analyzed after infection at 7,14,21-day.Observation of clinical symptoms at 7,14, 21-day after infections with CAV.Results indicated that the GD-1-12isolate caused high mortality about 30%,belonging to highly pathogenic.After infection at 14day,resulting in severe thymic atrophy,hepatomegaly,bursa atrophy,spleen atrophy.After challenging at 7-14day,the CD3+T cells in thymuses and peripheral blood were significantly decreased,it indicated that T lymphocytes were the target cells. The research further illustrated that after infection at 7-14day was the critical period of the immune function with the serious obstacle.


The experiment was conducted with ten cultivars of sweet sorghum to know the ethanol recovery and biochemical composition from stalk juice and grain. At physiological maturity, maximum recovery of ethanol (9.12%) was obtained from the stalk juice of NSS-208, which was found to be highest in total sugar (17.40%) and lowest in reducing sugar (1.46%). The AKSSV-24 cultivar was also showed higher ethanol recovery (9.03%). The significantly superior grain starch content were reported by NSS-104 (72.5%) and Keller (71.6%) which ultimately turned to maximum yield of grain ethanol i.e. 44.96 and 44.57% respectively. Further biochemical analysis of grain revealed that maximum amylose and amylopectin were found in NSS-104 followed by Keller, as well as NSS-104 found significantly superior in fat content (4.3%). Maximum content of phenol was observed in BJ-248 (0.7%). Amongst all, grain malt of BJ-248 recorded highest diastatic power (45.82. DUg−1) followed by NSS-04 (41.65 DUg−1). The analysis of bagasse remained after extraction of juice reported that cellulose and lignin content was maximum in bagasse of NSS-104 where as highest percentage of hemicellulose was obtained in bagasse of Wray.


Inadequate ingestion of nutrients in quality and quantities is common cause of infertility in ewe and mechanisms involved between nutrition and reproduction is changeable. The aim of this work was to evaluate the energy or protein restriction during lactation in ewe on return of reproductive cyclic activity. Twenty one females in post-partum was divided randomly in 3 treatments: control treatment (CT, diet supply the requirements for maintenance and lactation), caloric restriction (CRT, supplied ½ of the diet of the CT), protein restriction (PRT, supplied 1/3 of the protein of the CT). Trans-rectal ultrasound was performed to ovary evaluation weekly and the body weight were measured biweekly. Effect of treatment on number (P<0.0001) and diameter (P<0.0001) of follicle was observed. PRT (3.32 ± 1.79; 1.45 ± 0.15) was lesser CRT (4.12 ± 1.98 ; 1.55 ± 0.09) and CT (4.94±2.01; 3.32 ± 0.22). Interaction between treatment and week in follicles lesser or equal 3 mm (P=0,0007) and greater of 3 mm (P<0,0001) added the presence of corpus luteum (P=0.0319) in the CT demonstrated effect of energy or protein restriction in the cyclic pattens of nursing sheep. On the basis of the results conclude that the nutritional restriction affects the return of the cyclical activity in the post-partum of sheep.


The work is devoted to an analysis of racism in Brazil, based on the articulation of the concepts of biopolitics, necropoly and naked life, retaking the relevance of medical power to consolidate racism in the republican nation project and for the State to structure itself from it. Racism is then presented as a fundamental mechanism of power, and later, what is called a civilizing pact for silence as the main mechanism of racism, in order to demonstrate the civic reverberations of racial discrimination for the whole country, for as long as the racism is not based on historical narrative, we will not have racial democracy nor democratic government. The trajectory of the research passes through the theory of Michel Foucault, which exposes the impoverishment of historical discourse and its centrality to the maintenance of sovereign power, whose meaning Achille Mbembe goes back to colonialism and slavery. In the theoretical framework of Giorgio Agamben a rereading of the naked life is made from the dubious character of the abolition, what takes to denominate it barefoot life. In the meantime, the bibliographic review of Brazilian psychopathology at the turn of the nineteenth century for the twentieth century reveals how psychiatry significantly contributed to disguising and consecrating up to the present day the injury - always insulting but not always hostile. All these considerations are crucial for psychologists to rethink their practice, for although the profession is regulated by a code of ethics committed to the end of oppression, it alone does not forge an anti-racist stance that undoes ties with whitening.


Hurricane Cleo, moving northward, crossed Cuba and was over the water south of Miami on August 26, 1964 [l]. Reconnaissance aircraft were in or near the eye of the hurricane  almost  continuously on that  date.  The intensity, as indicated by their central pressure reports, remained constant at 984 mb. for 6 hr. during the afternoon and evening. As the center approached the Miami area,  rapid intensification occurred. The lowest pressure in North Miami was 971 mb. This intensification caused the maximum winds to increase from 85 m.p.h. to around 105 m.p.h., or roughly an increase of 50 percent in wind force. Figures 1 and 2 show the radar presentation a t 3:OO p.m. and 11:15 p.m. EST August 26, 1964. Mr. Gordon E. D u n , Chief Tropical Meteorologist, Homer Hiser and Harry Senn of the University of Miami's Radar Laboratory, and the Weather Bureau radar experts of Miami were asked which spiral overlay [2], the 10' or 20') better fitted each picture. This was done without the person's knowing the reason for the question. All agreed that the 10' overlay fitted figure 1 better and that the 20' overlay fitted figure 2 better, especially in close to  the eye. (Note  the narrow clear area.) This increase of inward spiralling of the rain bands probably indicates the increase in the low-level  flow and in the general intensity of the hurricane. While this  one  case is anything  but conclusive, it does indicate  an  avenue  for  further  research,  positive results of which would be invaluable.


Skin necrosis is a rare complication following subcutaneous injection of heparin. It is thought to be caused by a thrombotic phenomenon resulting from a platelet aggregation in heparin-sensitive patients. This aggregation can cause a cutaneous infarct and skin necrosis secondary to clot formation within the larger cutaneous vessels. This article reports a case of slin necrosis in a patient receiving subcutaneous heparin and discusses its possible pathogenesis and management.


Extended abstract: Evidence from the around the world suggests that human resource management (HRM) practices, such as increased employee participation in decision making and compensation systems that relate employee compensation to firm or group performance, have become increasingly common (e.g. for the US, Blasi and Kruse 2006; Freeman et al, 2009; for the UK, Pendleton and Robinson, 2008; for Japan, Kato 2006, and for Finland, Kalmi and Kauhanen, 2008). Accompanying these trends there has been an outpouring of research that investigates the impact of HRM practices for enterprise performance. And there is an enormous variation in the specific methods used and the focus of that literature. Thus some literature examines varying combinations of HRM practices --e.g. Freeman et al construct indices based on 8 practices while other studies focus on one practice, such as stock options—e.g. Sesil et al 2002. While most studies use firm level analysis (e.g. Robinson and Pendleton, 2008) others are case studies (e.g. Bartel et al 2004). Nevertheless, there does seem to be an emerging consensus that there is a positive association between packages of HRM and business performance. However for various reasons such conclusions may be premature—many studies have at least one potentially serious problem that might give pause before accepting conclusions.


Azo dyes are non-specifically reduced under anaerobic conditions, but the slow rates at which many dyes react may present a serious problem for the application of anaerobic technology as a first stage in the complete biodegradation of these compounds. Therefore, it is significant to explore the mechanism of anaerobic azo reduction, especially with respect to its kinetics. With that purpose, decolouration of the monoazo dye C.I. Acid Orange 7 (AO7) was studied in batch experiments. Experiments indicated that chemical reduction by sulphide is partially responsible for the anaerobic conversions of AO7. Mathematical evaluation of the experimental results pointed out that autocatalysis played an important role in the chemical reduction of AO7. Further tests made clear that 1-amino-2-naphthol was the dye9s constituent aromatic amines that accelerated the reduction process, possibly by mediating the transfer of reducing equivalents. The impact of redox mediation by quinones was further evaluated by testingthe catalysing effects of anthraquinone-2,6-disulphonic acid (AQDS) and of autoclaved sludge. AQDS appeared to be an extremely powerful catalyst, capable of increasing the first-order chemical reduction rate constants by a factor 10 to 100. Also autoclaved sludge, possibly because of mediation by sludge organic matter, accomplished accelerated azo reduction rates. Azo reduction in living sulphidogenic anaerobic sludge environments is 3 times more rapid than the chemically catalysed reaction with sulphide. The exact role of the biological activity remains to be clarified.


Glossopharyngeal neuralgia (GN) is a rare facial pain syndrome, characterized by paroxysm of excruciating radiating pain in the sensory distribution of the auricular and pharyngeal branches of glossopharyngeal and vagus nerves. In relation to the tonsil, the glossopharyngeal nerve passes deep to the styloid process and related muscles attaching to styloid process. The lingual branch of the glossopharyngeal nerve provides sensation to the posterior tongue and enters the tongue base by traveling through the constrictor muscles in the area of the lingulotonsillar sulcus. Post tonsillectomy fossa with exposed nerve causing intractable pain is a rare entity. We report a case of 64 year male patient, post tonsillectomy and transoral styloidectomy, with complaint of severe throat pain on left side for 2 years, radiating upwards to the ipsilateral ear, face and eye. Glossopharyngeal nerve and its branches were found exposed in the posterior and inferior aspect of tonsillar bed. Surgical resection of exposed glossopharyngeal nerve and its branches was carried out in view of failure to respond to oral carbamazepine. Patient was symptom free during 10 months of follow up visit. GN is a rare condition following tonsillectomy and styloidectomy. Radical dissection of tonsillar bed during tonsillectomy and not suturing tonsillar bed properly after styloidectomy can lead to exposure of glossopharyngeal nerve and its branches, resulting in intractable GN.


This paper demonstrates that the two completely different inflation outcomes of the currency crises in Serbia in the 1980s and in 2008–9, namely high and low inflation, respectively, can be explained by two distinct economic policy stances that can be traced back to different institutional environments. Large second-round effects of currency depreciation on inflation are detected in the former but not the latter crisis, and the reported estimates suggest that these effects were propelled by monetary accommodation and wage indexation. A side result was that exchange rate pass-through into prices was moderate and slow in Serbia in the 2000s, remaining unchanged even in the currency crash of 2008–9. These findings are consistent with recent evidence for developing economies. Serbia, along with a number of other emerging markets, has experienced two large balance-of-payment crises that have led to currency crashes, albeit with starkly different inflation outcomes. The crisis of the 1980s, which Serbia (then part of the former Yugoslavia) "shared" with Latin American economies, triggered high inflation that in a number of countries, including Serbia, spilled over into hyperinflation. In contrast, the currency crash of 2008–9 left inflation low in most emerging economies, including Serbia. This paper attempts to explain the two completely opposite effects that large currency depreciation has on inflation by exploring two currency crises in Serbia, one in the 1980s and the recent one in 2008–9. The conjecture we start from derives from Zorica Mladenovic; is a professor on the Economics Faculty at the University of Belgrade, Serbia. Pavle Petrovic;, corresponding author (email@example.com), is a professor on the Economics Faculty at the University of Belgrade, Serbia. The authors thank two anonymous referees and Josef C. Brada, editor of the journal, for useful comments. 66 EASTErn EuropEAn EconomicS an open economy model as advanced by Edwards (2006), which shows that wage indexation and/or an accommodative absorption policy can significantly enhance the initial pass-through from exchange rate depreciation to inflation. Thus different labor market configurations and policy responses might explain the contradictory impacts that currency depreciation has on inflation. Accordingly, we estimate both the initial and cumulative pass-throughs from the exchange rate to the price level while suggesting that the difference between them should capture second-round effects. Then we explore whether the size of these effects may be related to policy responses and the functioning of the labor market and, more generally, be traced to the different institutional setups. Former Yugoslavia in the 1980s: Soft Budget Constraints and External Debt Crisis Like a number of developing Latin American countries, Serbia (while still part of Yugoslavia) was hit by a foreign debt crisis in the early 1980s. This crisis, as well as the ensuing balance-of-payments crisis, triggered exchange rate depreciation and caused a full-scale currency crash. Serbia's currency started to depreciate in the early 1980s, losing on average 50 percent nominally per year, and the loss accelerated, for example, to over 70 percent in one year through September 1983 (see Figure 1). When the country was hit by a balance-of-payment crisis at the beginning of the 1980s, the real exchange rate depreciated almost 70 percent until 1984, then started to recover (see Figure 1). This indicates that Serbia experienced a full-fledged currency crisis in the first half of the 1980s. Triggered by large depreciation, inflation build-up started at the beginning of the 1980s, subsequently accelerated, and finally turned into short-lived hyperinflation in the last quarter of 1989 (see Figure 1). The inflation was briefly contained in 1990 by fixing a nominal exchange rate, albeit at the expense of sharp real appreciation (see Figure 1); nevertheless it started again in 1991. The latter coincided with the disintegration of Yugoslavia, which formally began in mid-1991. Average monthly inflation and currency depreciation were as high as 7 percent and money growth above 6 percent throughout this period, although they all varied considerably (see Figure 1). Against the background of Yugoslav inflation explained above, the following structural cointegrated system has been identified and estimated: p = 0.77w + 0.28e + u (1)


A series of studies has provided considerable evidence that the mixed lymphocyte interaction (MLI) 1 with rat cells can be a useful model for investigating the initial steps in the immune response to major transplantation antigens (H antigens) (1-6). The specificity, kinetics, and cell numbers involved in the reaction have been demonstrated (2, 3), as well as the fact that most of the lylnphocytes involved in the response are of thymic origin (6). One finding, that the proportion of antigen-reactive cells (ARC) to H isoantigens is large and is not significantly increased by immunization, suggests that immune responses to major transplantation antigens may be unique in some respects compared to reactions to other types of antigens (3, 5). The present studies were designed to extend our knowledge of the life history within the animal of those lymphocytes responsive to H isoantigens (hereafter called H-ARC) with particular emphasis on the life-span of these cells. Through the use of in vivo labeling with tritiated thymidine and subsequent examination of both peripheral blood smears and mixed lymphocyte reactions for labeled cells, the following questions about H-ARC were investigated: (a) Are H-ARC part of a "short-lived" or a "long-lived" lymphocyte pool; or more precisely, are these cells which have been recently produced in the intact animal through single or multiple divisions; or, by contrast, are these cells which have survived for a long period in vivo (with or without occasional divisions)? (b) Regardless of whether H-ARC are short-lived or long-lived in vivo, are they recently derived from the thymus or Call they be produced at extrathymic sites, perhaps by cells themselves derived from the ,thymus? (c) Are H-ARC a radiosensitive cell population?


Background: Even after a decade, the application of patient safety is still varied,
yet not many successes have been achieved and there are still some obstacles
although many parties potentially act as facilitators. External environment such as
external regulatory is thought to be one factor that could encourage the
implementation of patient safety in hospitals.
Objective: To identify the external regulation of patient safety


This study was designed to investigate the nutritional, anti-nutritional, amino acid profile and elemental constituents of the seeds of Aspilia Africana; a neglected and underutilized species (NUS). The nutritional and anti-nutritional contents of A. africana was determined using standard methods. The nutritional analysis showed the presence of carbohydrate (39.40±0.17%), crude protein (21.78±0.24%), fat (20.80±0.25%), ash (6.95±0.44%), crude fiber (9.70±0.25%) and moisture (1.31±0.02%). Anti-nutrients present include; oxalate (0 33±0.02%), saponins (2.96±0.04%), alkaloids (3,99±0.02%), phytate (0.13±0.00%), tannins (155.09±0.78 mg/100 g) and cyanogenic glycosides (4.30±0.06 mg/100 g). Amino acid profile was determined using the model 120a PTH amino acid analyzer. All essential and non-essential amino acids were detected. The seeds were found to be rich in amino acids (12.26 g/100 g-2.19 g/100 g), except for tryptophan (1.02 g/100 g) and cysteine (1.15 g/100 g). Macro and micro minerals found include: Calcium (Ca), potassium (K), Sulphur (S), Phosphurus (P), Iron (Fe), Copper (Cu), Rubidium (Rb), Manganese (Mn), Rhenium (Re), Gold (Au), Chromium (Cr), Nickel (Ni), Zinc (Zn) and Strontium (Sr). This shows that A. africana seeds are rich in nutrients and capable of ameliorating the acute food shortage being experienced the world over.


Aims To evaluate the survival and treatment outcomes of patients with nonendometrioid endometrium carcinoma after postoperative radiotherapy. Methods The records of 94 patients treated with postoperative radiotherapy (RT) between January 2005 and December 2011 were retrospectively reviewed. Postoperative RT was delivered with a dose of 45-50.4 Gy with 1.8 Gy daily fractions and brachytherapy was added to external RT for 62 patients with a dose of 3 × 6 Gy. Median follow-up time was 35 months (range 6-95 months). Results Median age was 63 years (range 43-83 years) and lymph node metastasis (LNM) was positive in 15 (16.0%) patients. The stage distribution of the patients was as follows: stage I, 58 (61.7%); stage II, 16 (17.0%); stage III, 18 (19.1%); stage IV, 2 (2.2%). Five-year locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) rates were 92.3%, 68.2%, and 78.6%, respectively. In univariable analysis, it was determined that the factors affecting OS rates were stage (p = 0.003), presence of LNM (p = 0.003), and presence of lymphovascular space invasion (LVSI) (p = 0.007); factors affecting DFS rates were stage (p = 0.019), presence of LVSI (p = 0.002), and having LNM (p = 0.049); and the factor affecting LRC rates was tumor size (>5 cm) (p = 0.011). In subgroup analyses, among all stage I patients, the DFS rates were lower for those with histologic grade 3 tumors and more than ½ myometrial invasion. Conclusions Due to its rarity, the prognostic factors and outcomes of nonendometioid endometrium carcinoma are not fully understood. In our analysis, stage, LNM, and presence of LVSI were found to be the most important prognostic factors. In order to tailor the optimal treatment strategy, prospective studies are needed.


During the outbreak of contagious diseases like Corona & Nipah, Social distancing and regular check-up of body temperature is very essential. Smart Cap is designed to overcome the problems faced by people who has to go outside homes during the outbreak. The cap senses any human that comes in one-meter radius and can alert them to maintain social distancing. The cap can be used for measurement of body temperature regularly and gives an alert if body temperature is higher than normal. It is also possible to check the body temperature of the people that we come in contact. It stores the live location of wherever the person has gone. If tested positive, the authorities can easily trace the places he went. A transparent face shield is also attached in the cap for prevention of risk of spread.


A retrospective chart review identified 11 patients with type 1 human immunodeficiency virus (HIV) who presented to an HIV/AIDS psychiatric service with an acute manic episode. Demographic data, neurodiagnostic studies, and treatment results are discussed. Abnormal brain magnetic resonance imaging significantly predicted poor tolerance of lithium and neuroleptics. Anticonvulsants were an effective alternative.


A mathematical model of pollutant removal by wet ponds was developed based on the mass balance principle and the release.storage equation. The release.storage equation can be linear or nonlinear depending on the wet pond shape and the spillway crest features. If the exponent index of the storage relationship (\id) is equal to the index of the outflow equation (\ib), the wet pond hydrological routing model is linear. Otherwise, the model is nonlinear. Substituting the release–storage equation into the continuity equation produces a nonlinear ordinary differential equation (ODE). A Runge–Kutta method was used to solve the resulting nonlinear ODE. When the ratio of indexes \id/\ib=2/3, the hydrologic wet pond model reduces to a special case that leads to an implicit analytical solution. The pollutant removal and flow routing models were tested with data obtained from an actual wet pond for treating highway runoff. The predicted flow discharges and pollutant concentrations compared well with the observed data.


Two-dimensional materials have modernized a broad interest in electronic devices. Along with many advantages, their atomic-level thickness makes them sensitive under high electrical stress. This work proposes a protection design using a Graphene/Silicon (Gr/Si) Schottky diode as the protective device, which helps to improve the endurance for unwanted fluctuations in operating voltage of 2D heterostructure-based devices. In this scheme, the 2D heterostructure was configured parallel with the protective device (Gr/Si diode) for electrical measurements. It was found that Gr/Si diode handles a large portion of initial surge current peaks, which significantly increases the durability and lifetime of 2D material-based heterostructure devices. This scheme potentially bridges mature CMOS technology and novel 2D-based heterostructure applications for robust futuristic devices.


Based on Rayleigh method,the energy function of multi-span continuous members with non-linear materials in press bending was proposed with Lagrange multiplier method,and its derivatives of the parameters concerned were gained,then the conditional expression was got where energy function has station,thus the approximate solution of the buckling load of multispan continuous members with non-linear materials could be educed when the determint of coefficient matrix equaled zero.The example calculation proved the high calculation accuracy of the method.


The urushiol titanium chelate was synthesized by reaction of urushiol with titanium tetrachloride in dimethyl benzene and charaterized primarily by means of IR and differential thermal analysis its solvency,thermal and chemical stability were studied as well.


The diffraction of guided optical waves on surface acoustic waves in a GaN layer grown by metalorganic chemical-vapor deposition on a (0001) sapphire substrate has been experimentally studied. The measurements have been performed at optical wavelengths 442 and 633 nm for the acoustic wavelength of 16 μm. The acousto-optic diffraction regime was close to the pure Bragg diffraction regime. The advantage of considerably lower acoustic power required at the shorter optical wavelength for diffraction is demonstrated. Our results show the potential of GaN-based structures for the development of blue acousto-optical devices.


During the last years, we focused on developing a prediction tool that utilizes the wide-angle observations of STEREO's heliospheric imagers. The unsurpassable advantage of these imagers is the possibility to observe the evolution and propagation of a coronal mass ejection (CME) from close to the Sun up to 1 AU and beyond. We believe that using this advantage instead of relying on coronagraph observations that are limited to observe only 14% of the Sun-Earth line, it is possible to improve today's CME arrival time predictions.
The ELlipse Evolution model based on HI observations (ELEvoHI) assumes an elliptic frontal shape within the ecliptic plane and allows the CME to adjust to the ambient solar wind speed, i.e. it is drag-based. ELEvoHI is used as an ensemble simulation by varying the CME frontal shape within given boundary values. The results include a frequency distrubution of predicted arrival time and arrival speed and an estimation of the arrival probability. ELEvoHI can be operated using several kinds of inputs. In this study we investigate 15 well-defined single CMEs when STEREO was around L4/5 between the end of 2009 and the beginning of 2011. Three different sources of input propagation directions (and shapes) are used together with three different sources of ambient solar wind speed and two different ways of defining the most appropriate fit to the HI data. The combination of these different approaches and inputs leads to 18 different model set-ups used to predict each of the 15 events in our list leading to 270 ELEvoHI ensemble predictions and all in all to almost 60000 runs. To identify the most suitable and most accurate model set-up to run ELEvoHI, we compare the predictions to the actual in situ arrival of the CMEs.
This model is specified for using data from future space weather missions carrying HIs located at L5 or L1 and can also directly be used together with STEREO-A near real-time HI beacon data to provide real-time CME arrival predictions during the next 7 years when STEREO-A is observing the Sun-Earth space.


Furfural residue, an industrial waste, is a kind of strongly acidic organic materials. Its comprehensive utilization in agriculture showed a significant effect on control of soil alkalization, amelioration of solonetz and increase of crop yields. In detail it may adjust pH, depress alkalinity, reduce bulk density and compactness and increase water permeability and retention ability of the soil. Meanwhile agricultural use of furfural residue provided an effective way to avoid its pollution of the soil, Water and air.


Executive Summary Lack of accessibility in the design of e-learning courses continues to hinder students with vision impairment. E-learning materials are predominantly vision-centric, incorporating images, animation , and interactive media, and as a result students with acute vision impairment do not have equal opportunity to gain tertiary qualifications or skills relevant to the marketplace and their disability. Due to its logical, rather than physical, nature IT help desk and network administration roles are ideal for people who are blind. This paper describes the development of a fully accessible e-learning environment to deliver advanced IT network curriculum to adults with acute vision disabilities. The components include a virtual classroom, accessible learning materials, a remote computer laboratory, and delivery of the learning materials by vision impaired instructors. Industry standard courses in advanced IT were redeveloped, and the accessible on-line learning environment was developed to deliver the courses. Vision impaired students who excelled in the pilot project were trained as instructors, gaining industry-standard instructor certifications. These instructors were used to assist with the design of accessible methods and delivered the materials to the vision impaired students. The project has been operational for four years with a pilot project being conducted over a two year period, followed by the delivery of the courses both local and remote vision impaired students across the globe using this accessible e-learning environment for the past two years. Evaluation results indicate that vision impaired students situated both locally and remotely gained equivalent grades to their sighted counterparts given additional time to comprehend and experiment via the virtual classroom and remote computer laboratory. In addition, the use of vision impaired instructors has resulted in more innovative approaches to accessible teaching methods and delivery of the curriculum.


War Eagle Series - two.; War Eagle series.; Items 32/10 through 32/10l are all part of the War Eagle series. There are 13 items in the series, including an introductory page (32/10).
Available also through the Library of Congress web site in two forms: as facsimile page images and as full text in SGML.
2 duplicate copies
Printed Ephemera Collection; Portfolio 32, Folder 10b.
Copy scanned: 2


Aiming at problem on false decision losses in fault diagnosis procedures,a new model named MRDTAN(minimal risk decision based on TAN)was presented,which integrates tree augmented naive Bayes(TAN)with minimum risk decision.Decision loss measure function was introduced to construct TAN based reasoning model with minimal risk criteria,based on which,a three layered reasoning mechanism was constructed so that the fault diagnosis could be minimized.The effectiveness of the model was validated with the operator's physiological parameters data set of aerospace system in practical diagnostic applications.Comparing with the diagnosis results of other relative intelligent inference models,the experimental results shows that Bayesian network classifiers with minimal risk criteria is lower total decision loss in diagnostic reasoning.


A low cost,high reliability position and speed sensorless control scheme is proposed in the paper.The paper has designed the sensorless controlling system of PMSM(permanent magnet synchronous motor) based on SMO(sliding mode observer) by analyzing the model of PMSM and the theory of SMO.The system is tested and verified on the experimental platform of sensorless PMSM system based on TMS320LF2407A DSP.The results show that the approach has better performance in position estimation and the system has better performance both in static and dynamic,thereby verified the correctness and availableness of the approach.


Living labs (LLs) have emerged as an interface for higher education institutions to collaborate with companies, citizens, non-profit and government organizations to address a variety of problems around social challenges and sustainable development. In this systematic literature review, we summarize the existing knowledge on how universities shape and manage the LLs they are associated with and how they align with their core missions of education and research and—in particular—their social missions. Following PRISMA guidelines for a systematic literature review (SLR), we analyzed journal articles, conference papers, and book chapters published between 2008 and 2020, capturing 93 university-governed LL experiences from across the world. Our findings show that LLs are developing from bottom-up initiatives, often at the fringe of higher education institutions, towards more self-standing entities implementing strategies to undertake social outreach activities. LLs require their host universities to intensify the relationships with their stakeholders and work on capacity building and focus on inter- and transdisciplinary research methodologies. Finally, our literature review points to the need for further research on the hybrid governance approaches displayed by LLs, particularly looking at the roles and responsibilities of academics involved in managing LL initiatives.


In this investigation, a method presented in a previous paper is applied to the following types of shallow shells: (1) Elliptic paraboloid; (2) hyperolic paraboloid; (3) hypar; (4) conoidal parabolic; and (5) soap bubble. Formulas are presented for the deflection and stress resultants at certain points of shells having a square projection.


This study examined the shear friction behavior of smooth construction joints and monolithic interfaces according to the equivalent compressive stresses generated from clamping forces of the transv...


Many studies have been shown and focused that variation of the quantity of vasoconstriction and blood pressure will cause the nonlinear chaotic behaviors in the heart blood vessel system and then induce the cardiovascular effect. Due to this kind of non-periodic motion is random and difficult to control, it is important to analyze and understand the status of dynamic system under different parametric conditions. In this paper, the differential transformation method is used to investigate the governing equations of system, and the dynamic behavior is characterized by reference to bifurcation diagrams, phase portraits, power spectra, and Poincaré map produced. The results indicate that the system behavior is significantly dependent on the magnitude of the vibrational amplitude. Specifically, the motion changes from T-periodic to 2T-periodic, then from 4T-periodic to 8-periodic, and finally to chaotic motion with windows of periodic motion as the vibrational amplitude is increased from 0.3 to 0.6. The results can be used as the basis for subsequent development of the control system design, and also reduced the possibility of cardiopathy.


Some of the forces pushing technology today are system speed, reliability, and cost of manufacturing. System speed has become less limited by gate speeds causing signal-line length to be the dominant factor. Shortening the distance between IC dies implies multi-chip modules. Reliability of circuit systems is a function of, among other things, the number of interconnections within the circuit system. Research needs to continue along several directions. This paper discusses a strategy for selecting materials and choosing fabrication processes based on the cost and availability of materials, equipment and facility. The density and performance that can be obtained within each silicon die will continue to improve. However, future advances in silicon technology will require substantial investment. The functionality of presently available silicon dies is adequate for most high-volume consumer applications. Development of the packaging and manufacturing systems for application of these dies can afford great benefits in terms of overall module costs. Research investment in these areas offers a potential for good returns with low risk. There is an urgent need for consideration of manufacturing systems aspects in the design of future electronics packaging.


The Public Lighting Improvement Prioritisation System (PLIP) was developed after meetings between members and officers of Birmingham City Council in England to discuss street lighting improvements. PLIP is a weighted database using nine factors, each of which is divided into different classes with their own data sources, geographical weightings, and weights. The factors are: (1) night-time traffic accidents with personal injuries; (2) recorded crime; (3) population density; (4) other significant factors; (5) residents' details; (6) transport facilities; (7) public centres; (8) maintenance problems and vandalism; and (9) traffic flows. Factors are given for high, medium, and low weights, respectively. This article provides details of each of these factors, with explanatory comments, and outlines how the PLIP system was tested and is being applied. To ensure that PLIP has a workable life, PLIP was tested in the 1997 lighting improvement programme, to see what values the proposed streets would be given. The article gives a numerical example of the calculations. The initial proposal is to apply the PLIP system to the 1050 currently unmet requests for re-lighting in Birmingham. The second stage will be to apply PLIP to the whole city, a task with considerable challenges.


With the development of modern automobile and aviation etc,application of light alloy and difficult to process material is more and more wide,and dry cutting is also more and more valuable.But dry cutting does not use coolant,so it is put forward new requirements for coating technology.The solid self lubricating is a good way to solve this problem.Therefore,it is a hot spot to research solid self-lubricating composite coating in recent years.On the basis of synthesizing large number of literatures,it is summarized the study about the characteristics and preparative technology of the self-lubricating composite coating,and is put forward the current existing problems and development prospects of prepared composite coating.


Objective To determine whether the psychological benefits of intense, inpatient, multimodal rehabilitation for persons with Huntington's disease (HD), as found in earlier studies, also apply in a shorter, day-care setting. Design Prospective, non-randomized cohort study. Subjects Twenty patients attending a group-based 8-week (3 days/week) rehabilitation programme aimed at persons in early stages of HD. Methods An explorative cohort study on register data from a specialized rehabilitation centre, including descriptive data, number of cancellations, a self-reported evaluation, and measures of psychiatric symptoms, health-related quality of life, sense of coherence and physical function at baseline and at the end of rehabilitation. Results Patients' attendance rate was almost 90%. Patients were satisfied, and displayed significantly reduced anxiety and depression and improved health-related quality of life after rehabilitation. Baseline measures of sense of coherence showed significant negative correlation with the number of cancelled days of rehabilitation. Physical function improved, but did not correlate significantly with psychological outcome measures. Conclusion These results indicate that an 8-week multimodal day-care rehabilitation programme can be tolerable, reduce psychiatric symptoms, and improve health-related quality of life for people with HD. A higher sense of coherence seems to promote attendance rates. Further larger studies, including the impact of cognition and disease progression on the treatment effect, are warranted. LAY ABSTRACT Huntington's disease (HD) is characterized by a triad of clinical features; motor, cognitive, and psychiatric. Physical training seems to have positive effects on motor symptoms. Earlier studies have shown that intense, inpatient, multimodal rehabilitation may also reduce psychiatric symptoms. The present study aimed to explore whether the psychological benefits are retained in a shorter, day-care setting.This study included 20 patients attending a group-based rehabilitation programme. The results show that participants had an almost 90 % attendance rate and were satisfied with the programme. After rehabilitation, they displayed significantly reduced anxiety and depression and improved quality of life. Sense of coherence showed a significant negative correlation with the number of cancelled days of rehabilitation. These results indicate that a shorter multimodal day-care rehabilitation programme can be easier to tolerate than longer programmes, and still reduce psychiatric symptoms and improve quality of life for people with HD. A higher sense of coherence appears to promote the attendance rate.


Acidovorax valerianellae had been reported a causal agent of bacterial black spot disease on corn salad in France, 2003 and on watermelon in Korea 2011. In this study, difference in host specificity between 2 groups, corn salad strains and watermelon strains, of Acidovorax valerianellae was recognized and compared. In the pathogenicity test, all 5 watermelon strains showed pathogenicity on the 6 Cucurbitaceae plants but not on corn salad, whereas 4 corn salad strains showed pathogenicity only on the corn salad. Utilization of Biolog substrates was different between watermelon strains and corn salad strains on 4 substrates, Malonic Acid, aHydroxybutyric Acid, a-Keto Butyric Acid, and Glycyl-L Glutamic Acid. The phylogenetic tree built with the 16S rDNA sequences showed that all of A. valerianellae stains was grouped into 1 clade separating from the other species of Acidovorax genus. Within A. valerianellae clade, watermelon strains and corn salad strains were separated into 2 sub-groups. REP-PCR analysis also separated the two groups. Host specificity, substrate utilization, and some genetic characteristics suggested that there are two pathogenic groups, watermelon group and corn salad group in A. valerianellae.


The European Telecommunications Standards Institute, ETSI, is working on standards for future broadband satellite systems. This paper offers an overview of the ETSI work, relates it to other important work by organizations such as the DVB Project, ITU and IETF, and discusses the potential application areas.


In this stady,all processes required to simulate the image reconstruction of a computer-generated hologram were conducted.Simulation of the reconstructed image of a full color rainbow hologram was successfully carried out.In a previous study,the reconstructed wavelength of the light used in the simulation consisted only of RGB.Therefore,the reconstructed image of white light was only possible when the simulation was done in the proper observation position.When the observation position was moved,the simulation could not be done.In this paper,we propose a method of continuous wavelength simulation that makes it possible to simulate a reconstructed image from any observation position.


Describes the trade-offs in establishing the design specifications for an advanced Roadway Powered Electric Vehicle (RPEV) demonstration project. Presents the results of many variations in system parameters as a function of operating frequency. These parameters include power transfer level, roadway current, onboard current, magnetic flux levels, and selected loss terms. Other factors such as onboard weight and acoustic noise are also addressed.


ABSTRACT Ethnic tourism is a catalyst for economic and sociocultural development in many countries. However, ethnic tourism development has given rise to many challenges associated with the sustainable development of ethnic regions within different cultural contexts. This paper addresses the social aspect of sustainable ethnic tourism through comparative case studies of two ethnic Hakka tourism destinations, Nanyuan and Sujiawei villages in Heyuan, Guangdong Province, China. The comparative case-study research design included in-depth interviews, document analysis and a household study in each case-study village. The comparative case study provides insights into factors contributing to socially sustainable ethnic tourism in China, including levels of community involvement, control of the tourism 'product', the benefits accruing to the ethnic community, perceived inconveniences/externalities and authenticity considerations. This study contributes to a better understanding of socially sustainable ethnic tourism in a Chinese context, and has practical implications for ethnic tourism destination marketing, management and policy-making.


. Light-absorbing organic species present in aerosols, collectively called brown carbon (BrC), contribute important but highly uncertain effects on climate. Clouds likely represent a significant medium for secondary BrC production and for bleaching reactions, though the relative importance of formation and loss processes in clouds is unknown at present. The acidity (or pH) of atmospheric particles and clouds affects the 15 optical properties of BrC and bleaching rates. Given the wide variability of pH in the atmosphere (pH in particles and clouds ranges from -1 to 8), the optical properties of BrC and its bleaching behavior are expected to vary significantly, and the link between pH and BrC is yet another uncertainty in attempts to constrain its climate forcing effects. In this work, we characterize the pH-dependence of BrC optical properties – including light absorption at 365 nm (Abs 365 ), mass absorption coefficient (MAC 365 ), and the absorption Ångström 20 exponent (AAE) – in bulk cloud water sampled from the summit of Whiteface Mountain, NY. In all samples ( n = 17), Abs 365 and MAC 365 increased linearly with increasing pH, highlighting the importance of reporting pH in studies of BrC in aqueous media. There was strong variability in the sensitivity of Abs 365 to pH, with normalized slopes that ranged from 5.1% to 17.2% per pH unit. The normalized slope decreased strongly with increasing cloud water [K + ], suggesting that the non-biomass burning BrC has optical properties that are 25 more sensitive to pH than BrC associated with biomass burning.


The North Atlantic Treaty Organization's nuclear forces were central to deterrence and defence during the Cold War. Their future role is far less clear in the dramatically changed security environment since its end. Despite concerns about the long-term evolution of Russia and China, the major threats to national and international security today stem not from confrontations between great powers, but from proliferation and terrorism.Proliferation concerns include Iran's suspicious and extensive weapons of mass destruction programs, especially its nuclear and missile activities. The discovery of the large enrichment facility at Natanz as well as other clandestine activities revealed two decades of Iranian noncompliance with its international obligations. North Korea's nuclear test and its diplomatic brinkmanship highlight the increasing dangers of its longstanding nuclear and missile programs and the difficulties of disarming the regime.The growing reality of cooperation among proliferant states is troubling. The weapons of mass destruction and missile cooperation between North Korea, Pakistan, and Iran have been examined in the open literature. The question is whether that cooperation was limited to these and a few other states, or provides a blueprint for the future. Clearly, there are a growing number of states that now possess or are developing WMD- and missile-related technological capabilities and expertise. Will these capabilities be shared, and under, what, if any, constraints? Will they wind up in black markets? All of these activities undermine regional stability and threaten US and NATO security, and could lead to proliferation "cascades" and regional arms races. There is a second tier of states that might consider nuclear or other weapons of mass destruction in the future, including Ukraine, Kazakhstan, Nigeria, Egypt, Turkey, Saudi Arabia, South Korea, Japan, and Indonesia.The potentially catastrophic nexus between rogue regime behaviour and terrorist tactics is also a grave concern. The active pursuit of nuclear and other weapons of mass destruction materials and technologies by terrorists and so-called rogue states has been abetted both by other proliferant states and by nonstate networks such as the A. Q. Khan operation. The risks to national and international security are compounded as peaceful pursuits of nuclear energy increase the global traffic in nuclear materials and technology.In response, the United States and NATO member states have advocated collaborative efforts to combat terrorism and to strengthen the nonproliferation regime while ensuring access to the advantages of nuclear energy. Multilateral counterterrorism initiatives include the "global initiative to combat nuclear terrorism." Efforts to strengthen and enforce nonproliferation norms are being reinvigorated through multilateral programs such as the proliferation security initiative and through efforts to gain universal adherence to the additional protocol to International Atomic Energy Agency safeguards agreements. The United States is currently pursuing a global nuclear energy partnership that would both encourage growth of domestic nuclear energy use and promote international arrangements to restrict access to fuel cycle technologies by additional states.International non- and counterproliferation, along with counterterrorism, efforts such as these are critical. However, they are not enough by themselves to protect US and NATO security interests, or to resolve global problems. The complex geopolitics ofthe emerging security environment, where issues of WMD proliferation and nuclear weapon policy intersect, demands a clear and credible security strategy that addresses US and NATO security objectives in multiple areas. These include ensuring confidence in the safety, security, reliability, and sustainability of the US nuclear-weapon stockpile and its supporting infrastructure; dealing responsibly with all weapon-usable materials, both nationally and globally; and meeting all international security commitments. …


The work deals with preparation of aqueous alumina suspensions determined for coatings deposition on ceramic joint implants by the method of spraying by pressure air. The surface treatment of implant consisting in its covering by ceramic layer containing "rough particles" improves its property from the bio-compatibility aspect, enables better guying of the implant and achievement of so called cement-free fixation. The alumina aqueous suspensions containing alumina particles of requested variable size, chosen additives and binders were prepared. For prepared suspensions was specified the rheological behaviour and basic rheological parameters characterising suspensions from view of spraying process course and prepared layers quality. Introduction In the modern surgical implantation are more and more applied materials on basis of alumina and zirconia ceramics. From the bio-chemical criteria aspects these materials belong to the group of stabile inert materials.[1]. The implants development is aimed to their service life increase in human body. The boundary between human bone and implant or bone cement and implant is decisive for long-term clinic results. The artificial joints can be anchored in human body by two wayswith or without bone cement utilization. Both fixing methods demand specific properties. From this point of view the convenient implant surface adaptation based on roughage of the anchored side of implants providing fixation improvement between the bond cement and implant (extended surface) or achievement of the so called cement-free fixation and so called osteophilic surface. For osteointegration improvement the rough surface can be covered by the bio-compatible crushed material. A lot of possibilities of such adapted surface (porous surface etc.) creation is presented. One of the possible way have to achieve the rough surface is covering of the implant surface by the layers containing certain share of rough particles of the identical chemical composition as the matrix. These layers can be applied by various technologies. The subject of the submitted paper is coating of these layers by the method of suitable suspensions of ceramic powders spraying. The applied layers have to meet the following parametersgood adhesion to the surface after lowtemperature and high-temperature processing, regular thickness (about 200 μm) roughness (R~ 14-17), uniform distribution of the rough particles within the surface. The prepared suspensions being used for the layers spraying of required parameters contain the following components: aqueous suspension of submicron powder with optimum deflocculant content, rough particles of size 50 μm 250 μm and chosen type of binder [2]. Materials and Methods For aqueous suspensions preparation was used alumina powder (D50= 0,4 μm, Reynolds). For suspensions stabilization was used deflocculant Dolapix CE 64 ( Zschimmer Schwarz, GmbH, Germany). Polysaccharides (on the D-galactose base, Omya, France) , hyaluric acid (Contipro, Czech Republic) and methyl cellulose (Colorcon,England) were tested as binder. The rheoviscometer Key Engineering Materials Online: 2004-05-15 ISSN: 1662-9795, Vols. 264-268, pp 2083-2086 doi:10.4028/www.scientific.net/KEM.264-268.2083 © 2004 Trans Tech Publications Ltd, Switzerland All rights reserved. No part of contents of this paper may be reproduced or transmitted in any form or by any means without the written permission of Trans Tech Publications Ltd, www.scientific.net. (Semanticscholar.org-13/03/20,18:13:32) Rotovisco RV1 (ThermoHaake, Karlsruhe) equipped with coaxial cylinder sensors was used for the determination of rheological behaviour. The apparent viscosity was evaluated at the shear rate of 50 s -1 , 100 s -1 , 500 s 1 and 1000 s -1 . Preparation of basic suspensions The water suspension was prepared by mixing of basic components in the planet mill ( Pulverisette 6, Fritsch, Germany). The solid phase content has ranged from 60%wt 80wt%, deflocculant content 0,2wt%-0,5wt% ( wt% based on dry solid mass). The deflocculation curves, i.e. graphs showing the dependence of the apparent viscosity η ( at shear rate of 50 s -1 ) on the deflocculant content are presented in Fig.1. for different solid content in the suspension. 0 0,1 0,2 0,3 0,4 0,5 0,1 0,2 0,3 0,4 0,5 mass % of deflocculant v is c o s it y η η η η 5 0 5 0 5 0 5 0 ( P a .s ) 60% 75% 77% 80% Fig.1. Determination of the optimum content of deflocculant for 72 wt.% , 75 wt.%, 77 wt.% and 80 wt.% suspensions of alumina powders. Rough particles preparation The rough particles were prepared by separation of alumina crushed material fired to 1000 o C in order to the particle size would ranged from 50 μm to 250 μm. The rough particles character is presented in Fig.2. Fig.2. Character of rough alumina particles 2084 Euro Ceramics VIII


The beginnings of the Howard University Department of Microbiology, a unit within the College of Medicine, trace to November 1866 when members of the First Congregational Society met in Washington, D.C., to develop a religious seminary for training black ministers. That idea quickly expanded to include educational, legal, agricultural, and medical components and the chartering of the University by an act of Congress in 1867.


Dietary polyphenols are very essential and are wieldy studied compounds due to their various biological activities. The anti-bacterial protein, lysozyme is beneficial drug carrying ability. Hence their binding at molecular level is essential perspective in the field of pharmaceutics. The bindings of quercetin with Egg albumin in a surfactant, SPAN 40 have been investigated using UV-vis, fluorescence and molecular docking studies. Quercetin is found to be the quencher of Egg albumin fluorescence and the quenching mode involved here is found dynamic in nature. The energy transfer parameters are calculated and a possibility of energy transfer from Egg albumin to quercetin is observed. Molecular docking study gives the distance of quercetin to egg albumin.


The invention discloses a video-recording-file-based data acquisition method and video-recording-file-based data acquisition equipment. The method comprises that: the identification information of monitoring equipment corresponding to monitoring data, corresponding time information and corresponding storage position information are recorded in a management server; the management server receives a request of checking the monitoring data of specified monitoring equipment and specified time from a video client (VC); the management server performs query by taking the identification information of the specified monitoring equipment and the specified time information as indexes, and transmits queried storage position information to the VC; and the VC searches for corresponding monitoring data from storage equipment according to the storage position information. By the method and the equipment, the position information of video recording data can be accurately indexed, thereby accurately obtaining the video recording data at the specified time.


GPS positioning technique,especially the rapid positioning method,nowadays is used for a whole variety of positioning and navigation applications.In this paper,we consider the common DD(double difference) model and introduce the double k type ridge estimator which is proposed by studying the character of multicollinearities in the normal equations matrix at first.Then,we improve the ARCE ambiguities search method through the double k type ridge estimator.At last we combine double k type ridge estimator and the improved ARCE ambiguities search method for rapid positioning.Theory analysis and computation results show that this new method can reduce the search time and improve the precision of float solution and ambiguities.


The purpose of this study was to analyze the functional ingredients of Curcumae longae Rhizoma extracts and to confirm the possibility of producing polyvinyl alcohol (PVA) nanofibers using these extracts. Distilled water and ethanol were used as extraction solvents. Terpene and its analogues as well as various volatile and essential oil components were detected in the distilled water and ethanol extracts. The total polyphenol content and flavonoid content showed that the Curcumae longae Rhizoma ethanol extract was higher than distilled water extract at 242.33 μg/ml and 166.65 μg/ml, respectively. PVA nanofibers containing Curcumae longae Rhizoma ethanol extract were electrospun in a relatively uniform manner without the occurrence of beads as a whole. As the content of Curcumae longae Rhizoma ethanol extract increased, the diameter of the fiber increased as well; the range of approximately 330 to 610 nm was added with a 0.25-1.5% addition. The hydrogen bonding between the Curcumae longae Rhizoma extracts and PVA, as well as the resulting degrees of crystallinity, melting point, and increase in heat capacity were identified through a Fourier-transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry analysis. Therefore, it was verified that the developed Curcumae longae Rhizoma/PVA nanofiber was created in a state wherein the bond between the molecules were smoothly achieved.


It is well known that technology is becoming increasingly prevalent among us, and that it is evolving at a quick pace. We're hearing more and more about artificial intelligence and how it affects our lives. Opinions on AI split the globe into two camps. Therefore, we choose to discuss what Artificial Intelligence is and how it marks our lives. Is it good to employ artificial intelligence? If so, how far should this be taken? Can it be used in a bad way? Sure, but this may also play a significant role in preventing and combatting cybercrime. All of these topics will be addressed in the next article


We developed self-consistent dynamical models of stellar systems in the framework of quasi-linear modified Newtonian dynamics (QUMOND). The models are constructed from the anisotropic distribution function of Gunn and Griffin, combined with the modified Poisson equation defining this gravitation theory and take into account the external field effect. We have used these models, and their Newtonian analogues, to fit the projected density and the velocity dispersion profiles of a sample of 18 Galactic globular clusters, using the most updated datasets of radial velocities and Gaia proper motions. We have thus obtained, for each cluster, estimates of the dynamical mass-to-light ratio (M/L) for each theory of gravity. The selected clusters have accurate proper motions and a well sampled mass function down to the very low mass regime. This allows us to constrain the degree of anisotropy and to provide, from comparison with stellar evolution isochrones, a dynamics-independent estimate of the minimum mass-to-light ratio (M/L)min. Comparing the best-fitting dynamical M/L with (M/L)min, we find that for none of the analyzed clusters the two gravity theories are significantly incompatible with the observational data, although for one of them (NGC 5024) the dynamical M/L predicted by QUMOND lies at 2.8σ below (M/L)min. Though the proposed approach suffers from some limitations (in particular the lack of a treatment of mass segregation), the obtained results suggest that the kinematics of globular clusters in a relatively weak external field can be a powerful tool to prove alternative theories of gravitation.


Oil is one of the strategic energies in the economy. The fluctuations will always be a favorite barometer of economists and world leaders. Therefore, this study aims to convert deeper into the world and monetary variables towards the Indonesian economy for the period 1996-2018. This study uses secondary data from the IMF and BPS. Variables are economic growth, oil prices, and interest rates. Perform the analysis carried out, namely descriptive analysis using Images and inferential analysis with Vector Error Correction Mechanism (VECM). The results of this study are common in the context of economic growth. Meanwhile, there is no economic growth. Meanwhile, at that time economic growth was influenced by economic growth in the first quarter, second and third quarter, growth in oil prices in the previous quarter, and economic growth in the previous quarter. The average value of ECT produced is negative and significant.


The non-linearities arising in the magneto-optical recording write channel are described. Their occurrence result in distortions that are damaging to the information circulating across the channel. For high speed data recording it is imperative to have a precise view of the transmission characteristics of a signal sent across the channel. When the non-linearity is weak, it is possible to perform Volterra series expansions to model the time response and port it to the frequency domain where non-linear distortions are derived from basic principles and applied to a general time dependent recording write channel.