The bone marrow (BM) microenvironment plays an important role in regulation of thrombopoiesis through release of thrombopoietic growth factor, among which thrombopoietin (TPO) is the most essential regulator. It has been realized that the TPO blood level and platelet count is inversely related, but the precise controlling mechanism is still under investigation. TPO is constitutively produced by the liver but can be induced to generate from BM mesenchymal stromal cells (MSCs) in pathological conditions such as thrombocytopenia. Since serotonin (5-HT) can be released from the active platelets when the body undergoing severe thrombocytopenia or stress, it may function as an essential humoral mediator regulating TPO production under this model. Our previous studies suggested that 5-HT enhances the growth of the colony-forming unit-fibroblast (CFU-F), a progenitor of MSCs (Yang M et al, 2007). However, the exact functions of 5-HT on MSCs and especially MSCs-derived TPO production are still under investigated. In this study, we showed that TPO RNA expression in hMSCs was enhanced in a time-dependent manner in response to the 5-HT treatment (200nM). The maximum reaction peak was observed at 24 hrs with 1.5-fold increase compared to the untreated control. A significant increase TPO protein was found in the supernatants secreted by 5-HT-treated hMSCs. The changes measured by ELISA and cytokinearray and were 4.5-fold (P=0.0372, n=4) and 2.14-fold increased compared to the control sample. Microparticles (MPs) are membrane-derived particles (0.1-1.0μm in size) produced from activated or apoptotic cells. They have been described as an important mediator in regulating a wide range of physiological and pathological response by transforming a spectrum of cytokines, signaling proteins, mRNAs and microRNAs. Recent studies have suggested that BM MSCs is one of the major sources for MPs production and that RNA contained in MSC-derived MPs can be isolated. Therefore, TPO mRNA released from MSCs could also be stored in MPs and released into the circulation or functions in a paracrine manner. In this study, in addition to the evaluation of the effect of 5-HT on naked-TPO release from MSCs, we also investigate its impacts on the RNA expression of TPO contained within the MSC-derived MPs. 5-HT was added to the hMSC culture for 24hrs, 36hrs and 48hrs respectively. It significantly stimulated MPs released from MSCs detected by flow cytometry. The maximal response time was observed at 36hrs. The AnnexinV positive population increased remarkably under 5-HT treatment (P=0.0007, n=4). HtMSC Cell movement and MPs released were visualized under phase contrast microscopy. HtMSC cells with 5-HT treatment were stained with AnnexinV-PE and the plates were inspected under the Tirf microscopy to trace the shedding process of MPs. By using phase contrast microscopy, a notable generation of MPs was observed from approximate 6hrs after the addition of 5HT, while only a little amount of MPs were detected in the untreated control group. Budding MPs were observed in 5HT-treated MSCs under both SEM and TEM. The morphology of these MPs was compatible to those published in other studies. And these results were complementary to our previous data obtained by flow cytometry and Tirf microscopy. Our data proved that hMSCs-derived MPs contained inducible TPO mRNA, which was enhanced under 5-HT treatment with more than 10-fold increase compared to the untreated control (P=0.0025, n=3). We further examined protein level of TPO in MPs using ELISA. The TPO protein level was increased more than 3-fold in 5-HT treated sample (P=0.0052, n=3). In summary, our findings suggested that 5-HT stimulated TPO released from MSCs in both dissociative and MP-bounded form, which indirectly promotes megakaryopoiesis and thrombopoiesis.

Disclosures: No relevant conflicts of interest to declare.


Research Findings: I examined the long-term association between the lexical and acoustic features of maternal utterances during book reading and the language skills of infants and children. Maternal utterances were collected from 22 mother–child dyads in picture book–reading episodes when children were ages 6–12 months and 5 years. Two aspects of language input were studied: lexical features (the amount and diversity of vocabulary, and the proportion of isolated target words) and an acoustic feature (the acoustic space of vowels). Standardized language tests were used to assess receptive vocabulary and language production abilities at age 5. The results showed that greater diversity of vocabulary and the use of fewer isolated target words during book reading with infants were associated with enhanced language skills in children 4 years later. Regression analyses showed that the proportion of isolated target words was the most potent predictor of, and acoustic vowel space also accounted for, variance in language expression skills at age 5. Maternal utterances and mothers' education jointly accounted for more than 60% of the variance in language abilities. Practice or Policy: These findings suggest that lexical and acoustic inputs in picture book reading with infants have long-term associations with children's language development throughout early childhood.


With the merits of a new technique, inverse emulsion polymerization, explorative experiments were conducted in making a kindof dry-strengthenning agent for paper. The product proved to have higher solid content and more obvious effect for paper strength.


Computational tests for ballistic impact energy absorption were developed on A356/CNTs composite material with the goal of estimating the improvement of the material's mechanical properties by the contribution of the CNTs [1]. For the implementation of computational tests on the material exposed to projectile impact, A356/CNTs was configured by means of generalized Hooke's model for anisotropic materials [1] and Johnson-Cook's model was used to determine material failure and propagation of energy [2]. A curvilinear surface (semi-spheres on a plaque) with an area of 23x23 cm and thickness of 12 mm was elaborated to represent the composite material. The impact on surface was done with a 9 mm projectile and the surface was developed with 4.5 mm radium semi-spheres. It was used a 0.3% of nanotube insertions on the composite total volume. The results indicated the plaque stopped the impact without drilling. Incidence of damage to wearer, as well as possibility of composite material improvement and the diffusion/dispersion analysis on the curvilinear surface was also done.


The thrust of this study is the implication of economic and social globalization on pro-poor growth. The KOF indexes of de facto and de jure globalization was utilized for this study. Data on the variables were obtained from the National Bureau of Statistics (NBS) and World Bank WDI among others. The data analysis was conducted using ARDL model, bounds cointegration and unit root test in addition to descriptive statistics. The results showed that the variables are fractionally integrated as observed from the unit root test. This finding necessitated the application of bounds cointegration which showed evidence of long run relationship between poverty headcount and globalization indexes. The ARDL results revealed that economic globalization has a positive and significant effect on poverty headcount in the short run. This finding is synonymous with the long-run results, which showed evidence of a significant positive effect of economic globalization on poverty headcount. The implication of this finding is that the benefits of economic globalization in terms of trade in goods and services, trade regulations and agreements, FDI inflows, portfolio investments, foreign debt, and other forms of financial globalization have not trickled down to the poor.The results further showed that social globalization has a negative and significant effect on poverty headcount. However, there is evidence of positive and insignificant effects of political globalization on poverty headcount in both the long and short run. Given the findings, it is recommended that policymakers prioritize social globalization to trickle-down its intended and desired benefits of poverty reduction.


The production method of food by using seed of black grain and oil crops is characterized by that it uses germinating seed to produce food, and mainly includes the following steps: soaking seed, disinfecting, germinating and drying. Said invented product can be non-pasted raw food, also can be pasted instant food. It contains the various physiological active substances of germinating seed, so that its nutrients are rich, and can be easily absorbed by human body.


One of the hallmarks of the oncology scientific community has been a general reluctance to sensationalize advances. Although the news media tends to blare forth with the breakthrough of the week, or even du jour, investigators reporting results usually cloak them with caution and almost always point to the need for further studies. This is not to say, however, that the oncology community is shrouded in a pall of pessimism. The willingness to treat these devastating diseases and provide compassionate support and hope, grounded in realistic expectations, has earned the specialty the (sometimes begrudging) admiration of non-oncology practitioners. And for many years, one of the precepts that enabled oncologists to provide honest succor to patients was the well-grounded belief that progress was being made, if slowly, in small but well-defined increments. Thus, the breathtaking change in pace we see now in understanding the underlying mechanisms of carcinogenesis and introducing innovative approaches to therapy based on this understanding that now confronts (blesses) the oncology world evokes almost a sense of disbelief. I would guess that, for the past decade, no clinician has left a major meeting thinking, "nothing really new is happening." Multiple myeloma, highlighted in this issue, may well serve as the cover disease for this remarkable change of pace. When first published, the NCCN Multiple Myeloma Clinical Practice Guidelines rested squarely on standard alkylating agents and corticosteroid treatment or well-tested regimens such as VAD that had been the mainstay of treatment for more than 30 years. Since this initial guideline was originally released, two remarkable new agents, thalidomide, reported in 1999, and bortezomib, reported in 2003, have been added to the list of efficacious agents for the management of advanced disease. Patients with refractory or relapsing myeloma now have solid options for achieving meaningful responses, with increases in time to progression and perhaps even survival. Ongoing studies are now incorporating these agents into new combinations, and these studies will, hopefully, lead to even more beneficial responses. The area of high-dose therapy with bone marrow support has shown the greatest changes. As detailed in the review by Bensinger, researchers appear to have solid evidence for the role of high-dose, autologous-supported chemotherapy, either up front or at the time of relapse, in improving overall survival. Of possibly greater import is the profusion of studies of allogeneic-oriented therapies that may lead to even more durable control of the disease. The path is not an easy one; transplant-related toxicity and mortality is still a reality. However, experiments with non-myeloablative regimens and controlled graftversus-myeloma interactions make cautious optimism a reasonable outlook. And as repeatedly pointed out in JNCCN articles, the goal must always be defined in terms of patient benefit. Lee's review of the role of quality of life studies being interjected into all phases of myeloma testing speaks to the tremendous emphasis on assessing new therapies from a quality as well as quantity perspective. This becomes especially essential for treatments that carry significant side-effects. For instance, meaningful assessment of the role of interferon is not 269


Contributing Authors.List of Figures.List of Tables.Acknowledgements.Forward by S. K. De Datta.I. The Need to Globalize IPM through a Participatory Process.1. The Need for Cost-effective Design and Diffusion of IPM (George W. Norton, S.K. DeDatta, Michael E. Irwin, Edwin G. Rajotte, and E.A. Heinrichs)..2. The Participatory Integrated Pest Management (PIPM) Process (George W. Norton, Edwin G. Rajotte, and Gregory C. Luther).II. Developing Strategic IPM Packages.3. Developing IPM Packages in Asia (Sally A. Miller, Ed Rajotte, Rezaul Karim, Aurora Baltazar, N.S. Talekar, and George W. Norton).4. Developing IPM Packages in Africa (J. Mark Erbaugh, John Caldwell, Sam Kyamanywa, Kadiatou Toure Gamby, and Keith Moore).5. Developing IPM Packages in Latin America (Jeffrey Alwang, Steven C. Weller, Guillermo E. Sanchez, Luis Calderon, C. Richard Edwards, Sarah Hamilton, Roger Williams, Mike Ellis, Carmen Suarez, Vicor Barrera, Charles Crissman, and George W. Norton).6. Developing IPM Packages in the Caribbean (Janet Lawrence, Sue Tolin, Clive Edwards, Shelby Fleischer, D. Michael Jackson, Dionne Clark-Harris, Sharon McDonald, Kathy Dalip, and Philip Chung).7. Developing IPM Packages in Eastern Europe: Participatory IPM, Research in Albanian Olives (Doug G. Pfeiffer, Josef Tedeschini, Lefter Daku, Myzejen Hasani, Rexhep Uka, Brunhilda Stamo, and Bardhosh Ferraj).III. Deploying Strategic IPM Packages.8. IPM Transfer and Adoption (Edwin G. Rajotte, George W. Norton, Gregory C. Luther, Victor Barrera, and K.L. Heong).9. The Key Role of Farmer Field Schools (Gregory C. Luther, Colette Harris, Steven Sherwood, Kevin Gallagher, James Mangan, Kandiatou Toure Gamby).10. Pesticide and IPM Policy Analysis (George W. Norton, Jessica Tjornhom, Darrell Bosch, Joseph Ogrodowczyk, Clive Edwards, Takayoshi Yamagiwa, and Victor Gapud).11. Pre-inspection IPM for Export Horticulture Markets (Glenn H. Sullivan, James Julian, Guillermo Sanchez, Steven Weller, and George W. Norton).IV. Evaluating Strategic IPM Packages.12. Evaluating Socio-Economic Impacts of IPM (George W. Norton, Keith Moore, David Quishpe, Victor Barrera, Thomas Debass, Sibusiso Moyo, and Daniel B. Taylor).13. Evaluating the Health and Environmental Impacts of IPM (Leah Cuyno, George W. Norton, Charles Crissman, and Agnes Rola).14. Gender and IPM (Sarah Hamilton, Keith Moore, Colette Harris, Mark Erbaugh, Irene Tanzo, Carolyn Sachs, and Linda Asturias de Barrios).V. Conclusion.15. Lessons learned (E.A. Heinrichs and S.K. DeDatta).Index.


On 4 August, a 22-year-old male tourist from London presented at a hospital in Jerusalem, Israel with general malaise, a high fever and a blotchy maculopapular rash over his face trunk and limbs, including palms and soles.


We report the rare occurrence of fatal cardiac tamponade due to coronary sinus and right atrial thrombosis associated with central venous catheterization. The clinical course was extremely rapid, with death occurring a few minutes after the acute clinical event. Other causes of acute cardiac tamponade were ruled out by the postmortem studies.


SIR, idiopathic aquagenic pruritus is a distinct clinical entity characterized by generalized skin itching or a pricking, tingling, burning or stinging sensation without visible skin changes at sites of direct contact with water in which no underlying diseases can be detected. Although benign in nature, itch related to the disease can have a significant impact on the sufferer's quality of life. In addition, treatment is usually disappointing, with a poor response to oral antihistamines as well as to other antipruritic therapies. We report two patients in which good therapeutic response was observed after narrow-band ultraviolet (UV) B phototherapy. A 27-year-old woman presented with a 20-year history of aquagenic pruritus in which oral antihistamines and alkalinization of bath water had proven to be ineffective. Physical urticaria testing was negative. Biochemical and haematological studies were within normal limits. Because of failure of standard treatments, phototherapy with narrow-band UVB was proposed. Narrow-band UVB phototherapy was carried out in a cabin equipped with 18 narrow-band UVB tubes (Philips TL-01 lamp, 100 W ⁄01). The first irradiation dose was determined by skin phototype. The full-body treatment was carried out three times per week with dose increments each session of 10–20%. No other concurrent systemic or topical therapy for pruritus was added. After 7 weeks of three-weekly treatments (maximum treatment dose 1 J cm) her symptoms had resolved completely so that she was able to take a bath without discomfort. Once the clinical response had reached a plateau, treatment was continued for another 2 weeks. Tapering of the narrow-band UVB was accomplished by decreasing the frequency of treatment to twice a week, and to onceweekly 2 weeks later. Clinical symptoms, which relapsed after 3 weeks while still receiving one weekly session, were again well controlled after a second course of twice-weekly narrowband UVB. After 20 weeks (total dose 35Æ8 J cm), the addition of oral desloratadine, which had previously proven to be ineffective as monotherapy, allowed her to reduce the phototherapy to a once-weekly narrow-band UVB session without reappearance of clinical symptoms. The patient's pruritus remains well controlled after 7 months by maintenance treatment every week. No side-effects other than occasional episodes of slight erythema have been observed. A 52-year-old woman presented complaining of an 8-year history of pruritus, related to showering or swimming, lasting for 20–30 min without clinical lesions. She had previously been treated with different antihistamines and moisturizing without any benefit. A complete blood count and differential as well as blood chemistry profile did not show any abnormalities. Treatment with a three-weekly narrow-band UVB regimen, as previously described, resulted in rapid improvement of the pruritus in only a few sessions with complete resolution of the symptoms 4 weeks after the start of phototherapy (12 treatments, cumulative dose 5Æ2 J cm). Phototherapy was continued for another 4 weeks and thereafter reduced to a once-weekly session, which allows her aquagenic pruritus to remain under good control after 4 months. Symptomatic treatment options for aquagenic pruritus are limited and often unsatisfactory. Phototherapy, particularly psoralen + UVA (PUVA) therapy, has been effective in some cases. Nevertheless, it does not usually induce prolonged remissions, and thus, maintenance treatment is required. Because of this, the risk of repeated courses of PUVA must be weighed against the benefits. Broad-band UVB has been associated with symptomatic relief in only about 50% of cases. Narrow-band UVB therapy has been successfully used for the treatment of inflammatory and pigmentary skin disorders, pruritic dermatoses as well as pruritus in polycythaemia vera. In the latter, UVB-induced mast cell apoptosis in addition to UVB-induced alteration of the cutaneous immune system may play a role. In our experience, narrow-band UVB was a well-tolerated and effective therapy in idiopathic aquagenic pruritus resistant to other therapies. To the best of our knowledge this is the first report concerning the application of narrow-band UVB in aquagenic pruritus. Nevertheless, remission was short-lived and maintenance therapy, as previously described after PUVA therapy, is likely to be needed. Narrow-band UVB is considered to be a reasonably safe treatment. Although the long-term safety of narrow-band UVB with regard to skin cancer risk needs to be monitored, this risk is deemed to be lower than that associated with PUVA. The addition of oral antihistamines could be useful in some cases in order to reduce the frequency of sessions required for maintenance therapy, as seen in one of our patients.


Results of work on the application and development of quantitative methods for the determination of pollutants from emission sources by remote sensing, combining infrared radiometry and spectroscopy, are presented. The method has proved to be feasible. Generalized temperature and concentration models, based on the theory, plus certain empirical factors have been developed and their applicability has been demonstrated. Field measurements a t 65 meters distance on gas-fired power plant plumes a t temperatures 500-600°K were made, and CO, NO, and N02, and CHI plus saturates and C2H4 plus unsaturates concentrations were determined. Temperatures can be determined to within k10"K and concentrations to within &28% of the value over the range 10-104 ppm as well. Extension of the method to temperature and concentration gradients and to fluctuations in plumes due to chemical reactions as well as to measurements a t greater distances appears to be feasible.


Objective To study the correlation between serum level of creatine kinase of MB type(CK-MB) and prognosis in acute paxaquat-poisoned patients.Methods 41 patients with acute paraquat poisoning were divided into 2 groups:death group and survival group. The final clinical outcome was defined as either death or survival in hospita1.The serum level of CK-MB at 24 h after poisoning was detected by kinase method and analyzed by statistics.Results Mortality rate of 35 patients with elevated serum CK-MB was 77.14%(27 of 35). The serum level of CK-MB was significantly higher in death group than in survival group(P0.05).Conclusion Acute paraquat-poisioned patients with elevated serum CK-MB often predict a severe status, poor prognosis,and high mortality rate.


Emphysematous pyelonephritis (EPN) is a severe, necrotizing infection of the renal parenchyma, produced by gas-forming Gram-negative bacilli. Even though only few cases are reported in the literature, the disease is not so rare and can become life-threatening if the diagnose is not quick and the therapeutic messures efficient. The biochemical analysis are the first line diagnostic, indicating the severity of the infection. The aim of our study was to to evaluate the importance of biochemical parameters, as first line diagnosis and also of the microbiological parameters, as etiologic diagnosis, in severe renal infections produced by gas forming bacili mainly in diabetic patients, predominantly women, with obstructive nephrolithiasis.

https://revistadechimie.ro/count_redirect.asp?RevChimieID=5658&pdfArticle=pdf/28 GRIGORE N 6 17.pdf


ABSTRACT :This study measured the mechanical and damping properties of EPDM compounds including fillers. Semi-re-inforcing furnace black (SRF), high abrasion furnace black(HAF) and acetylene black were used as fillers. Dicumyl peroxide(DCP) were used as curing agents. The measurements were conducted using a moving die rheometer (MDR), durometer, universal testing machine (UTM), compression set and dynamic mechanical analysis (DMA). The tensile strength and elonga-tion at break increased with increasing SRF contents in EPDM compounds. However, they decreased with increasing the amount of acetylene black. In the inspecting temperature range, EPDM compound filled acetylene black had stable storagemodulus. Furthermore, the tan δ of the EPDM compounds obtained was enhanced by compounding with acetylene black. Keywords : EPDM, mechanical properties, damping properties, HAF, SRF, acetylene black † Corresponding Author. E-mail: email@example.com Ⅰ. 서 론 과학 기술이 발전함에 따라 환경문제에 대한 관심의 증가로 인하여 생활환경을 침해하는 진동의 감소에 대한 요구는 점점 증가하고 있다. 특히 자동차 엔진을 비롯한 산업 기계 전반에서 진동을 억제 또는 감소시키기 위한 방진기술은 정밀기기의 발달에 따라 요구조건이 강화되고 있다.


The development 0/Social Studies in the New Zealand Curriculum over the 1993-1997 period was highly contested. The authors were directly involved in the social studies development over this period, and this paper reflects on some of the major events in the development, from our "insiders" viewpoint. The paper argues that the contest was strongly influenced by two major "dominant voice groups with very different views on luhat a social studies curriculum should be like and by key elements of the political and economic reform agenda of the day. The paper traces the rise and fall in influence of each "dominant voice" group and also examines the way in which the reform agenda changed throughout the development. It argues that in the end the inclusive and liberal-democratic voice ivas dominant over the neo-liberal and educationally conservative one. It also suggests that a return to a more cooperative, negotiated style of curriculum development, rather than a pure "market-contract model" approach, luas needed to bring the development to a satisfactory conclusion.


Increased focus on air pollution from gas turbines in the Norwegian sector of the North Sea has resulted in taxes on CO{sub 2}. Statements made by the Norwegian authorities imply regulations and/or taxes on NO{sub x} emissions in the near future. The existing CO{sub 2} tax of NOK 0.82/Sm{sup 3} (US Dollars 0.12/Sm{sup 3}) and possible future tax on NO{sub x} are analyzed mainly with respect to operating and maintenance costs for the gas turbine. Depending on actual tax levels, the machine should be operated on full load/optimum thermal efficiency or part load to reduce specific exhaust emissions. Based on field measurements, exhaust emissions (CO{sub 2}, CO, NO{sub x}, N{sub 2}O, UHC, etc.) are established with respect to load and gas turbine performance, including performance degradation. Different NO{sub x} emission correlations are analyzed based on test results, and a proposed prediction model presented. The impact of machinery performance degradation on emission levels is particularly analyzed. Good agreement is achieved between measured and predicted NO{sub x} emissions from the proposed correlation. To achieve continuous exhaust emission control, the proposed NO{sub x} model is implemented to the on-line condition monitoring system on the Sleipner A platform, rather than introducing sensitive emission sensorsmore » in the exhaust gas stack. The on-line condition monitoring system forms an important tool in detecting machinery condition/degradation and air pollution, and achieving optimum energy conservation.« less


How to play the media in a single operating system that supports smart services and DTV services are provided. The method loads a single operating system that supports smart services and DTV service in the memory, the basic media player included in a single operating system receives the playback request target medium from an application, in a single operating system the basic medium player determines the type of identifier (ID) included in the target medium, the basic medium player of the DTV player or VOD player to be distinguished from the basic media player in accordance with the type of identifier with the target medium of any one of select the player, selected players to play the target media. .FIELD 8


For a grasping task planner, the pre-planning of the reachable tip pose in a manipulator's workspace is important. On this basis, for a seven-degree-of-freedom (7-DOF) redundant manipulator, it is very meaningful to study how to give full play to its redundant characteristics to achieve more dexterous grasping. In this paper, through the improved shape primitive method, the reachability spheres of the 7-DOF manipulator studied were more accurately captured, and a more accurate reachability capability map was generated. Then, based on the idea of redundancy angle discretization, the concept of the obstacle avoidance ability (OAA) index is innovatively proposed to measure the dexterity of the grasping task of the manipulator in a certain tip pose. Based on the OAA index axis, the distribution of the OAA index in each reachability sphere was analyzed. The prediction models of the OAA index of all reachability spheres in the workspace of the manipulator were obtained by the Levenberg–Marquardt algorithm and finally formed a dexterity capability map of the manipulator, which provides a new idea for the pre-planning of the dexterous grasping task of the redundant manipulator. Finally, we give the general frameworks of different grasping pre-planning by combining two kinds of capability maps and verify the effect.


CBCT assessment of impacted canine improves canine localization to adjacent teeth and provides higher level of confidence in the treatment plan compared to 2D images. However, there is conflicting evidence to support using CBCT as a routine first-line imaging method in patients with impacted maxillary canine and incisor root resorption. Consequently, there are doubts regarding difference in diagnostic and treatment planning between the use of conventional 2D and CBCT sets. Therefore, the present review will attempt to summarize the new aspects regarding the benefits of three-dimensional (3D) diagnostic techniques (cone-beam computed tomography, CBCT), including the accuracy of localization of impacted canine and the detection of the degree and location of root resorption of maxillary incisors.


The formation of a coloured product in the reaction of acetone with m-dinitrobenzene and alkali was first noted Janovsky Erb in more Janovsky the wide scope of the reaction


In this study, the roller pressure quench process is applied on a low‐alloy steel plate with significant thickness. The aim is to obtain martensitic high strength steel without modifying the flatness. In order to optimize the process parameters, a finite element model is developed. The analysis couples the mechanical, thermal and metallurgical fields. This model provides results about the final microstructure, the residual stresses and the flatness at the end of the cooling process. It has been noticed that a two dimensional plane strain simulation is not accurate because it does not predict physical transversal residual stresses. A three dimensional simulation improves the results and enables to compute the thickness variation of the plate at the end of the quench process.


Acoustic wave devices are an attractive technology for use in sensors since acoustic waves present high sensibilities to external parameters in terms of phase velocity and damping. This technology is very interesting in environments such as Internet of Things, where low power consumption is a central requirement. The main drawback of this technology concerns the application and the reliability of the RF signal powering the sensor that makes necessary the use of virtual network analyser or spectrum analyser. Although in literature examples of acoustic wave devices used with external antennas have been discussed, to the best of our knowledge, at the state of the art acoustic devices integrated with an antenna have not been reported yet. This paper will discuss the possibility to realize a wearable, compact remote sensor, totally passive, fully integrated with the antenna. The wearable sensor is based on a Surface Acoustic Wave (SAW) resonator designed to operate at 800 MHz and realized on a flexible and biocompatible polymeric substrate, made of Polyethylene naphthalate (PEN). The SAW resonator consists of a pair of reflecting gratings, defining the acoustic cavity, and an interdigital transducer (IDT) placed at the centre of the cavity. The distributed feedback cavity shows a high Qfactor Q ≈ 2×105 when 200 reflectors are considered.


Ivo John Carre received his early training in paediatrics in London and Birmingham, and was later a research fellow in Melbourne. In 1956 he became senior lecturer in child health in Belfast, and subsequently (1963) professor in that department, retiring in 1984.

He had a most distinguished career in paediatrics, and he …


The feasibility of a mesophilic anaerobic treatment of an alcohol distillery wastewater beet molasses stillage was studied in a l Up ow Anaerobic Sludge Blanket UASB reactor for a period of days The system was seeded with L of mesophilic anaerobic sludge harvested from the bottom of a dairy anaerobic lagoon Nutrients were added to acidi ed e uent and after adjusting the pH in an equalization tank the system was fed with a diluted e uent containing COD in the range of mg L at C Initially the system had an OLR of kg COD m d and up ow velocity was maintained at m h HRT h throughout the study A gradual increase in OLR through increased feed concentration resulted in an excessive sludge washout necessitating the addition of calcium carbonate to act as a nuclei for granule formation After days of operation and at an OLR of kg COD m d signs of granule formation were observed as indicated by increased VSS at the bottom of the reactor and reduced e uent VSS At this point the loading to the system was increased in four stages up to kg COD m d COD removal e ciency of to evaluate the optimum operational conditions of the system During this period the VSS SS ratio remained constant at and the SLR varied from to kg COD kg VSS d The performance of the system based on unit reactor volume and unit microbial mass was kg SCOD m d and kg SCOD kg VSS d respectively


An on-chip oscillator 108 provides the appropriate clock frequency for components 112 of the chip 106 to manage power consumption by the chip. More specifically, in a preferred embodiment of the present invention, an on-chip oscillator is utilized to provide the clock frequency for the chip's core circuitry, and such oscillator can dynamically adjust such clock frequency to manage the chip's power consumption. Thus, such on-chip oscillator generates the processor clock instead of the usual synchronous, externally controlled clock generator. A preferred embodiment of the present invention utilizes a voltage controlled frequency oscillator to control the chip's clock frequency in order to dynamically manage power consumption by the chip. Such oscillator is preferably operable to adjust its output frequency based on the voltage supplied to such oscillator to effectively manage the chip's power consumption.


The following work has been developed with the intention of knowing what is the design process in computer science? Its importance, which are the parts that make it up, on the other hand this cycle of the same its application in the engineering and the management of the change in the improvement of processes. A process is known as a set of organized and coordinated activities that are performed or developed under certain circumstances with a specific purpose, on the other hand it can be said that design is the previous process of mental configuration in the search for a solution in any field. the design process is integrated as follows Formulation of the problem, Analysis of the problem, Search for solutions, Improvement, Decision, Solution specification, Realization.


The structural synthesis problem, which is currently viewed as an inequality constrained minimization problem in design variable space, is transformed into an unconstrained minimization problem in a space such that each point represents a set of values for the design variables as well as for each behavior variable in each load condition. Using penalty functions and a trial value of the optimum weight (W0)^ rather than slack variables and Lagrange multipliers, a positive function i/' is constructed such that any point where \[/ = 0 represents an acceptable design of weight W0 or less. This integrated formulation is used to seek optimum designs by systematically reducing W0, thus generating a sequence of acceptable designs with decreasing weight. Numerical examples of optimum designs, based on a nonlinear analysis for a one node m-bar planar truss, are presented together with computer running times. These results are obtained using a steep-descent-type procedure in conjunction with the \//function formulation. The results indicate that the integrated approach offers the prospect of making substantial improvements in the efficiency of the structural synthesis process, particularly when linearization of the structural analysis is inappropriate.


Water Margin is the famous classical novel,and also Jinyong's favorite book.So when he wrote novel at the first time,Jinyong drew lessons from Water Margin in plot,theme and character images,and finished his masterpiece——stories of books and swords.


Introduction: Clean and suitable drinking-water is a key component to enhance human health. However, obtaining safe and adequate water is limited in many developing countries. Besides, treated drinking-water are often contaminated at storages and point of use with contaminants and consumption of unclean water poses a great public health problem. This study aimed to assess the determinants of drinking-water quality and sanitary risk levels of water storages in food establishments of Addis Ababa, Ethiopia. Institution-based cross-sectional study was conducted. 125 food outlets were selected using a simple random sampling technique. Then, 125 drinking-water samples (250 from each) were collected directly from the food outlets drinking-water storages. Moreover, observational checklist was used to assess determinants of drinking-water quality and sanitary risk levels of the storages. Data analysis was conducted using multivariable logistic regression.Results: This study revealed that, 28.5% of the drinking-water was contaminated with fecal coliforms. Besides, based on WHO criteria, 16.3% and 18.7% of the food outlet drinking-water storages were grouped into high and very high contamination risk levels respectively. Seven (7) explanatory variables were identified as main determinant factors which significantly associated (p-value < 0.03) with the contaminated drinking-water. Conclusion: Most of the food establishments' drinking-water was free from bacteriological contamination and safe from biological hazards. However, significant number of food establishments' drinking-water storages had fecal contamination. In the study, many determinant factors that affect drinking-water quality of the food outlets were identified. Therefore, good sanitation and hygiene practice should be practiced at the food establishments. Besides, creation of awareness about drinking water contamination and its health risks should be done by concerned bodies.


This codec has two kinds of bit rates,i.e.,5.3 kbps and 6.3 kbps,which correspond to two different algorithms.For 5.3 kbps codec,Algebraic Code Excited Linear Prediction(ACELP)principles are used,while for the 6.3 kbps codec,Multi Pulse-Maximum Likelihood Quantization(MP-MLQ)techniques are used.Firstly,the encoding and decoding principles of the source coder of G.723.1 and the C program which is an integral part of the recommendation are analyzed.Then how to implement G.723.1 codec based on ADSP-2189M.Lastlyis analyzed.And optimizing methods at algorithm and code lever are also discussed.And the re-sults have great practical significance,which can be applied to low-rate voice transmission on the network.


Age specific changes in brain mitochondrial bioenergetics. The mitochondrial oxygen consumption rates (OCR) are expressed for five brain sub-regions (A-E). In general, all the regions of the brain followed identical patterns where the maximal respiratory capacities (State V and State V Succ ) were reduced as a function of increasing age (Y>A>M=O). The State III respiration in BS, CER and HIP demonstrated a similar pattern as observed for the maximal respiratory capacities (Y>A>M=O); whereas the FC and STR displayed the highest State III rates in the adult group amongst all the age group compared here (A>Y≥O≥M). The proton leak (State IV) remained unaffected. (*p<0.05 vs. age groups). Bars are group means + SEM, (n=5 animals per group).


Recently, solar-driven interfacial water evaporation has shown great potential in desalination. In the practical application, the inevitable pollution and the accumulation of salt making the evaporation efficiency cannot be maintained for a long time. Herein, we reported a flexible and economical superhydrophobic photothermal membrane composed of polyvinyl pyrrolidone (PVP) and carbon nanotubes (CNTs) with 1H,1H,2H,2H-Perfluorodecyl triethoxysilane modification, and a piece of expanded polystyrene was used for support and thermal insulation. The prepared floating evaporation device shows a high energy efficiency of 91.1% and evaporation rate of 1.41 kg m-2 h-1 under one solar irradiation, and neither salt accumulation nor significant decrease in evaporation rate of the device was observed after either continuous operate for 40 h or 18 evaporation cycles. In addition, the self-cleaning performance of the membrane enables its surface to maintain high absorbance for a long time. With the stable and efficient evaporation performance of this device, it provided guidance for the application of efficient and long-term stable solar desalination.


4. Brimacombe J, Berry A. The incidence of aspiration associated with the laryngeal mask airway-a meta-analysis of published literature. J Clin An&h 1995;7:297-305. 5. Barker P, Langton JA, Murphy PJ, et al. Regurgitation of gastric contents during general anesthesia using the laryngeal mask airway. Br J Anaesth 1992;69:314-5. 6. Owens TM, Robertson l', Twomey C, et al. The incidence of gastroesophageal reflux with the laryngeal mask: a comparison with the face mask using esophageal lumen pH electrodes. Anesth Analg 1995;80:980-4.


The meaning of green house was illustrated and present status of green house was analyzed.The countermeasures to develop green house were proposed from investors,consumers and governments.It pointed that the green house was newly,dynamic and developing human settlement space,which can develop healthy need countermeasures of society every parties.


This paper presents an approach for translating multi-device task models to a distributed execution model based on state machines. We consider an expressive extension to ConcurTaskTrees, called multi-device ConcurTaskTrees (MCTTs) as a modeling language for distributed multi-device applications. We use the device labeling operators Any and All, which specify if user interactions at runtime shall take place on one or all of a set of devices and extend the translation algorithm for "classical" CTT operators with translation rules for these multi-device operators in a distributed setting. Our algorithm exploits concurrent and hierarchical state machines for the execution and the concept of partial state machines during the translation.


There is provided a feedback provision method including specifying, by a processor, an action generated in a target and a generation time of the action on the basis of sensing data of the target, determining feedback to be provided in accordance with the specified action, and providing the feedback at a time corresponding to the generation time.


Thirty well isolated ro-vibrational transitions of the 30011e – 00001e band of 12 C 16 O 2 at 1.54 μm have been recorded with a laser-locked cavity ring-down spectrometer. The line intensities were obtained with accuracies better than 0.85%. Comparisons of the line intensities determined in this work with literature experimental values and those from HITRAN2016, AMES, UCL-IAO and CDSD-296 line lists are given. © 2017 Elsevier Ltd. All rights reserved.


STUDY OBJECTIVE
To test the hypothesis that individuals chronically noncompliant with antituberculous chemotherapy are vectors for ongoing transmission of the disease in the community.

DESIGN
Cohort study.

SETTING
A large public hospital with a tuberculosis detention unit for patients with repeated and prolonged nonadherence to therapy.

PATIENTS
Mycobacterium tuberculosis isolates from patients confined on the detention unit were obtained from the hospital's mycobacteriology laboratory.

INTERVENTIONS
None.

MEASUREMENTS AND RESULTS
A standardized IS6110-based Southern blot hybridization protocol was used to genotype M tuberculosis isolates recovered from patients confined on the detention unit at the hospital. Each DNA fingerprint pattern was compared with the IS6110-fingerprint database at the Public Health Research Institute Tuberculosis Center, which has archived fingerprint patterns from over 2,500 M tuberculosis isolates collected from New York City patients in the past 5 years. Eighty percent of available isolates from detained patients belonged to an identifiable DNA fingerprint cluster, suggesting an epidemiologic link between the detainees and other New York City tuberculosis patients.

CONCLUSIONS
Chronic noncompliance with therapy is associated with ongoing spread of tuberculosis in the community. Aggressive measures, including detention, for the small number of recalcitrant, noncompliant patients may interrupt a chain of transmission and contribute to a decline in the spread of tuberculosis in urban areas.


To the Editor.— Taylor and Harris 1 recently reported experiments which they interpreted as demonstrating that the fluorocarbon propellants used in asthma inhalers produced a toxic effect on the heart of anesthetized mice, which could explain sudden deaths in asthmatics and which casts doubt on the safety of other aerosol products. We believe that their findings may be explained on a physiologic basis which is related to the asphyxia rather than a specific chemical cardiotoxicity, and we believe that deductions made in the paper about the safety of other aerosol products therefore are open to question. The "cardiac toxicity" of the propellants was demonstrated by Taylor and Harris in the following manner. Mice anesthetized with pentobarbital sodium were exposed to the inhalation of an unknown but presumably very high concentration of the propellants for a few seconds. Following this, their heads were enclosed in a tightly fitting plastic bag. These


With a cell phone camera a person can take pictures and imme diately transmit them to larger repositories using telecommunication channels. This provides the potential for anywhere, anytime picture sharing and story telling. It can also increase awareness among peers within a social network. But while we enjoy telli ng stories around this informal content, the necessary act of downloading, organizing and then presenting the digital media is tedious and can discourage frequent use. We present PLOG, an application that stresses ease-of-use story telling through cell pho ne photography. The user simply takes pictures and performs simple click -and-send uploads using their phone. From a local machine, PLOG automatically downloads the images; time clusters the pictures together and then presents them as story vignettes. These vignettes can be viewed different ways and at home, shared with friends or posted in public places. We describe the implementation of PLOG and di scuss issues related to this light -weight method of story telling and awareness.


Author(s): Saldanha, Karl Johann | Advisor(s): Majumdar, Sharmila | Abstract: Stem cells have shown promise for tissue regeneration in a variety of pathological conditions. Specifically, mesenchymal stem cells have demonstrated the ability to promote tissue repair of the musculoskeletal system through differentiation along specific lineages including bone, cartilage, muscle, and fat. As part of the ongoing development of stem cell therapies and the gradual transition of these techniques into the clinic, it is crucial to be able to monitor these cells following implantation into the body. Magnetic resonance imaging (MRI) has the capability to provide in vivo non-invasive imaging of cells at multiple time points following implantation. As such, these research studies focus on the development of techniques to generate contrast between cells and the surrounding environment on MR images using iron-based methods. In particular, these studies focus on the application of such techniques to stem cell tracking for tissue engineering of the musculoskeletal system. The techniques investigated include cell loading with iron oxide-based contrast agents of various sizes as well as genetic engineering strategies to increase iron uptake through modified protein expression. Studies using iron oxides demonstrate the ability to non-toxically label cells, detect them via MRI, and quantitatively characterize signal loss associated with labeling. However, issues with excess particles following labeling could potentially hinder the accuracy of this approach. Furthermore, aggregation of excess particles during in vitro stem cell differentiation precludes the ability to utilize conventional staining techniques to assess the effect of labeling on differentiation capacity. Genetic engineering studies on (non-stem cell) mammalian cells suggest no effect on iron uptake resulting from expression of the bacterial gene magA. However, ferritin up-regulation results in increased iron uptake in transiently transfected cells, but not enough to enable MRI detection. Further studies focused on generation of ferritin expressing stable cell lines as well as cells expressing gene combinations known to play a role in iron uptake are warranted. While significant research is still necessary before iron loading techniques can be transitioned into a clinical setting, the promising results of these studies and the clear potential benefits of its successful development are a strong motivation for continued investigation.


In cotransmission, a ''classical'' neurotransmitter, such as a biogenic amine like noradrenaline, dopamine, or 5-hydroxytryptamine, is released along with another regulatory compound, such as a peptide, to influence the postsynaptic membrane. Studies on neuronal cotransmission involving peptides were preceded by reports of peptide hormones and biogenic amines coexisting in cells of the gastrointestinal tract (see, e.g., Pearse, 1969; Ownman et al., 1973) and of the coexistence of nonpeptide neurotransmitters in invertebrate neurones (see, e.g., Kerkut et al., 1967; Brownstein et al., 1974). The burgeoning interest in peptides concurrent with the development of immunofluorescent techniques applied to the mammalian nervous system led to the observation that some peripheral noradrenergic neurones contain immunoreactivity to both somatostatin and dopamine-0-hydroxylase (Hokfelt et al., 1977). This was rapidly followed by the demonstration of the coexistence of substance P and 5-hydroxytryptamine in the rat brain (Chan-Palay et al., 1978; Hokfelt et al., 1978). The following years saw the investigation of a large number of examples of coexistence of "classical" and putative peptide neurotransmitters in both central and peripheral neurones (see, for example, Hokfelt et al., 1980; Cuello, 1982; Lundberg and Hokfelt, 1983; Bartfai et al., 1988; De Biasi and Rustioni, 1988). "Classical" neurotransmitter biosynthesis occurs principally in the terminal, by enzymes that are synthesised in the cell body and transported down the axon. Before the neurotransmitter can be utilised by the cell, it must be taken up and stored in secretory vesicles, which are made up of components elaborated in the cell body. Replenishment of stores of conventional neurotransmitters such as biogenic amines can occur by local synthesis within the terminals and by reuptake into the terminal of released transmitter. The peptide cotransmitters, by contrast, are synthesised in the cell body as part of a larger precursor that is incorporated into membrane-enclosed compartments as it is being formed. These compartments mature, via the Golgi apparatus, into vesicles, and the regulatory peptides are formed by excising the peptide sequence from its precursor (the propeptide) by limited proteolysis, mostly but not always at sites of double basic residues (usually Lys-Arg), and by other maturation events such as amidation. The vesicles containing peptides are transported to the terminals where they accumulate before release. Unlike the conventional transmitters, replenishment of peptide stores cannot occur at the terminals: further supplies of peptide for release must come from the cell body. The biogenic amines such as dopamine and noradrenaline would, therefore, appear to have a clear advantage over peptides with respect to responsiveness to changes in demand. This sketch of presynaptic aspects of cotransmission illustrates the disparate nature of the two biosynthetic pathways for amines (for example) and peptides, which must be coordinated for a cotransmitting neurone to function. The extent to which the apparent difference in responsiveness of the two neurotransmitter types will be realised depends on the supply of vesicular material. Local synthetic capacity for a neurotransmitter cannot result in an increased responsiveness to demand unless there is also local availability of other components required for packaging, storage, and release of the neurotransmitter. If vesicular components are lost once exocytosis occurs and if resupply of vesicles is dependent on supply from the cell body, then respon-


We introduce ultra high speed electron beam tomography as a new imaging tool for multiphase flow measurement and small animal imaging. The technique is based on imaging with X-rays produced by a rapidly scanned electron beam instead of a mechanically rotating source-detector compound. The scanner device ROFEX was developed manufactured and commissioned recently at FZD and allows scanning of objects with up to 7.000 frames per second speed and 1 mm spatial resolution. Application examples from multiphase flow measurement and small animal imaging are presented. Multiphase flow imaging mainly benefits from fast scanning which is impossible with any other imaging technology at this temporal and spatial resolution. Small animal imaging with ultra fast electron beam CT, however, is still in its beginning. Here higher spatial resolution and 3D imaging is needed.


This paper considers a nonlinear internal model design based on the contraction theory (or simply contraction). A sufficient condition is presented for constructing a class of internal models enjoying certain input-to-state stability. The method is further applied to solve an output synchronization problem of a class of second-order leader-follower multi-agent systems. An example of synchronizing a group of mass-spring systems with a Rayleigh oscillator is given for an illustration.


DISA molding line had been used formerly to produce the planetary stand cast with QT600-3 grade nodular iron,and shrinkage porosities occurred in some bosses.By improvement of casting method and pattern-tools,the rejection rate has been reduced to 11.7%.Later the Toku molding line was adopted as the substitute of DISA line and put heavy part of the casting into the cope,as well as the casting process was simulated with Huazhu CAE / InteCAST software.The production result showed that the rejection rate has been reduced to 1.84%.


An image forming apparatus includes a transfer belt unit which has an intermediate transfer belt for supporting toner images and primary transfer rollers for pressing the intermediate transfer belt against corresponding photoreceptor drums and moves the intermediate transfer belt along the surface of each photoreceptor drum to transfer the toner images to the intermediate transfer belt. The intermediate transfer belt is formed so as to be 30 mum to 50 mum in average thickness, each primary transfer roller is arranged at a position, along the moving direction of the intermediate transfer belt,which is deviated downstream with respect to the moving direction from the position where the intermediate transfer belt is in contact with the photoreceptor and which is projected toward the photoreceptor drum side so as to press the intermediate transfer belt against photoreceptor with a nip pressure ranging from 10 gf/cm2 to 40 gf/cm2.


This article mainly demonstrates the current status and issues of food waste disposal throughout the country,analyzes the features of food waste and evaluates the level of management. Engaging in developing the management policy of food waste disposal plays a key role in protecting the environment,improving the health of citizens,and achieving the goal of reducing,utilizing and decontaminating food waste. Strategies and suggestions about improving the management of food waste disposal will be proposed according to analysis.


The dynamic response of non-uniform functionally graded beams subjected to a variable speed moving point load is studied by using the finite element method. The material properties of the beams are assumed to be graded in the thickness direction by a power law. A beam element, taking the effects of shear deformation, cross-sectional variation and the shift in the neutral axis position, is formulated by using exact polynomials obtained from solutions of the governing differential equations of a homogeneous Timoshenko beam element. The dynamic responses of the beams are computed by using the implicit Newmark method. The numerical results show that the dynamic characteristics of the beams, including the maximum mid-span deflection, mid-span axial stress distribution are greatly influenced by the acceleration and deceleration of the moving load. The effects of the moving speed, material non-homogeneity, cross-section variation as well as aspect ratio on the dynamic response of the beams are investigated in detail and highlighted.


The article by Koffler and colleagues presented an interesting hypothesis attributing hydranencephaly to elevated hematocrit levels in a newborn. The hypothesis is quite reasonable, but appears to be based on shaky clinical evidence.
 The authors make it clear that their determinations of hematocrit levels were made on capillary blood, but do not make it clear how they were obtained. Their statements about polycythemia and hyperviscosity relate to venous blood. Since no studies of viscosity were performed, it may not be justifiable to assume that because the capillary hematocrit was greatly elevated, hyperviscosity was present.


I have been favoured with a letter from M. Haussoullier, Professor of Greek Antiquities at Bordeaux, respecting the Prienian decree which I published in the last number of this Journal from the MS. copy of Mr. Murray. M. Haussoullier, whose valuable contributions to Greek epigraphy are well-known, especially to readers of the Bulletin de Correspondance Hellénique, tells me that he visited Prienè in 1879 and took an impression and copy of this same inscription. He has very kindly communicated to me the readings in which his impression differs from Mr. Murray's MS. The comparison proves the general accuracy of Mr. Murray's copy. Line 9.—Murray τὸν χρόνον: Haussoullier τὸγ χρόνον. Line 19.—Murray ὅπως δαμη, from which I restored ὅπως δ[ε]μή: Haussoullier ὅπως δ'ἀ… only.


Socialism is an important component of Zhang Junmai's liberalism. His socialism not only has a foundation of deep Chinese traditional culture, but also has the west philosophy background, especially the Germany and Britain. It has gone through the change course from social democraticism to state socialism and then to socialist democracy. His liberalism has deep and rational composition, but because of the contradiction of this theory itself and particularity of the Chinese context, it becomes "the scheme that can't be fulfilled" finally.


Increased tobacco control measures in recent years have directed the tobacco industry to develop alternative tobacco products, such as "heat not burn" (HnB) tobacco devices that are implied to be less hazardous than conventional cigarettes. There are extensive studies from manufacturers available, which show that the emissions of HnB tobacco devices have significantly lower levels of harmful substances compared to conventional cigarettes. In addition, manufacturers have published studies to investigate whether switching from a conventional tobacco cigarette to the HnB product reduces possible health risks. The purpose of this report is to review current studies by manufacturers and independent institutions as well as to discuss possible reduced health hazards. The German Federal Institute for Risk Assessment (BfR) has carried out its own studies of selectedanalytes in the emissions of one HnB product confirming the lower levels of harmful substances in the emissions. The results are consistent with data from other independent studies. The nicotine content in the emissions is in the same range as the nicotine emissions of conventional cigarettes, which suggests a comparable addictiveness and dependence potential. Manufacturers have reported mutagenic effects of emissions by HnB tobacco devices that, however, are considerably weaker compared to conventional cigarettes. Nevertheless, the use of the HnB tobacco product remains associatedwith health risks. Switching from conventional cigarettes to tobacco heaters can significantly reduce the consumer's exposure to harmful substances. However, this article also illustrates that it is still unclear to what extent the reduced levels lead to lowered health risks. Therefore more independent studies, but also long-term studies, are needed.


In 1986 the United States Department of Commerce National Oceanic and Atmospheric Administration (NOAA) instituted the nation's third Mussel Watch Projet. The projet is designed to monitor the spatial distribution and temporal trends of concentrations of trace elements and organic chemicals in the coastal and estuarine environment


We will present results which show lasing on the 3p yields 3s (J equals 0 yields 1) transition in neon-like chromium (Z equals 24), iron (Z equals 24), iron (Z equals 26), and nickel (Z equals 28) at 285, 255, and 231 angstroms respectively. This destroys the myth of titanium being unique and makes highly unlikely that the previously mentioned photo-pumping mechanism is playing a significant role in the titanium laser. The chromium, iron, and nickel experiments all require a prepulse in order to lase and our calculations suggest that the prepulse is an exciting new way to create a uniform low density plasma when illuminating a thick slab target. This allows the proper conditions for gain and laser propagation for low Z neon-like ions and may also be applicable to other systems such as low Z nickel-like ions. We also will present experiments done on other low-Z materials and offer an explanation as to how the hyperfine effect is destroying the gain of neon-like ions with odd Z.


The aim of the research is to improve the public's assessment and understanding of the cultural values and history of Bulgaria. The main issues related to the sustainable use of elements of the cultural heritage are defined, and the accessible literary sources related to the digitization of the folklore heritage are reviewed. Shape indices, color, and textural characteristics were obtained from digital color images of the elements of Bulgarian folk costumes. The most informative indices of these features were selected. A kernel variant of the principal component analysis (kPCA) method was used to reduce the data volume of the feature vector. A Naïve Bayes classifier, discriminant analysis, and the support vector method (SVM) were used for classification. The classification accuracy was assessed. In the analysis of the decorative elements of Bulgarian costumes, it was found that the accuracy of classification depended both on the method for reducing the volume of data and on the separability of the classes of data, depending on the classifier used. In the analysis of microscopic images of textile fabrics from Bulgarian costumes, it was found that the accuracy of classification for the studied objects depended both on the method for reducing the volume of data and on the used classifier. In the considered cases, a classification error below 10% was obtained using a non-linear kPCA kernel and SVM with a non-linear partition function. It was proven that the results of this development can be used in the creation of modern cross-stitch patterns, textile patterns, and clothing. The practical application of these research findings has the potential to benefit various stakeholders, including cultural heritage institutions, researchers, artisans, designers, and the general public, promoting a deeper appreciation and sustainable use of costume embroidery elements. Research can continue in the direction of the sustainable use and preservation of embroidery elements of Bulgarian costumes, enriching the understanding of cultural heritage and promoting appreciation for it in future generations.


For the accurate characterization of the dielectric properties of substrates used in electromagnetic (EM) applications, robust techniques have been developed including plane-wave illumination, waveguides and resonators to meet this requirement. In previous work, the authors introduced a Waveguide-Resonator method; the resonator is the CFSS - complementary frequency selective surfaces, for dielectric constant measurements (C.C. Njoku et al., Proc. EuCAP, 2420–2422, 2013). Examining the resonant frequency, quality (Q) factor and insertion loss differences of the CFSS with and without the material under test (MUT), the permittivity and loss tangent of the MUT can be calculated. This method required the MUT cut to the WG aperture size and placed next to the CFSS within the WG in a closed environment. This paper examines the use of an open WG with one end covered by the CFSS and the sample placed over the WG flange to fully cover the aperture. Whilst the Q is low, this technique is versatile and low cost.


Studies are limited in terms of assessing the physical component at early ages of development and focusing on blindness. Most of the studies related to blindness were carried out in order to contribute to the development of motor skills and not to the study of the physical component. Therefore, the research evolved from a current physical diagnosis of the blind student, the selection of methods and functional tests with their adaptations, as well as the assessment of the viability of their application in special education. It was found that the comprehensive pedagogical diagnosis has limitations, since it does not include aspects of the physical component, which hinders the adequate direction of the pedagogical process of Special Physical Education. In this study, methods from both the empirical and theoretical levels were used, with the case studies being of great significance. In general, it has been observed that the Centos de Diagnostico y Orientacion do not apply tests to evaluate the physical component of blind schoolchildren, which affects the quality of the physical education teaching process.


This chapter explains that the answer to most "why does English do this?" questions will be a variation on things that were discussed in the previous chapters: old habits getting reinforced while new habits take over, unnoticeable slow drifts in pronunciation, the practice of extending or borrowing or creating in order to get something useful, reusing materials at hand in new ways, the drive to get more emotional impact, the need to look smart, impress, send social signals, express national pride. It will be because of the old Germanic layer, the French upheaval, the consolidating force of the printing press, the purposeful manipulation done by snobs, or the natural tendencies of our human language endowment. When language changes it is never the whole system changing at once. It happens one piece at a time, and the pieces do not coordinate or even communicate with each other while they do this. Contradictions will not be noticed until they are already baked in. English, because of its history, has a lot of them, but that does not stop the system from working. It does not stop people from learning to use it and making sense of what does not seem to make sense.


This paper proposed a method to compensate the wavelength change of Yb doped fiber laser caused by temperature variation by controling the dielectric reflector position.


Combination of a fourth-order Pade compact finite difference discretization in space and a fourth- order Runge-Kutta time stepping scheme is shown to yield an effective method for solving highly nonlinear standing waves in a thermoviscous medium. This accurate and fast-solver numerical scheme can predict the pressure, particle velocity, and density along the standing wave resonator filled with a thermoviscous fluid from linear to strongly nonlinear levels of the excitation amplitude. The stability analysis is performed to determine the stability region of the scheme. Beside the fourth- order accuracy in both time and space, another advantage of the given numerical scheme is that no additional attenuation is required to get numerical stability. As it is well known, the results show that the pressure and particle velocity waveforms for highly nonlinear waves are significantly different from that of the linear waves, in both time and space. For highly nonlinear waves, the results also indicate the presence of a wavefront that travels along the resonator with very high pressure and velocity gradients. Two gases, air and CO2, are considered. It is observed that the slopes of the traveling velocity and pressure gradients are higher for CO2 than those for air. For highly nonlinear waves, the results also indicate the higher asymmetry in pressure for CO2 than that for air.


This bachelor's thesis contains abstract of altern ative energy supplies for garde nand week-end house and describes their advantages and d isa vantages. The selected alternative energy supplies are: water-power, solar energy and wind energy. Final part of bachelor's thesis discuss with a constructi on machinery for wind energy useage and describes parts of machinery.


Alkaline water electrolysers are widespread in many industries, including systems with hydrogen cycle of energy storage. One of the problems of modern alkaline water electrolysers is insufficient purity of generated electrolysis gases relative to electrolysis systems with solid-polymer electrolyte. In this regard, work on modification of existing porous diaphragms is actively carried out. One new area of research is the impregnation of new hydrophilic fillers into the composition of existing diaphragms and the transition to ion-solvate membranes. In this work the synthesis of zirconium hydroxide hydrogel inside a porous diaphragm with the hydrophilic filler TiO2 was carried out. This synthesis makes it possible to obtain a membrane with anion-exchange properties. A possible mechanism of OH- hydroxyl ion transfer by immobilized K+ ion was also proposed. The obtained results demonstrated the resistance of the membrane to concentrated alkaline solutions.


To the Editor: We read with great interest the recent article ''Verrucous Hyperplasia of the Great Toe: A. Case and a Review of the Literature,'' by Scheinfeld et al. They reported that verrucous hyperplasia etiologies included vasculopathy, friction, severe stasis dermatitis, poor prosthetic fit and alignment, and bacterial infection and that these factors induce pressure gradients, causing the proximal stump to develop greater pressure than the distal stump, resulting in edema and verrucous change. The treatment of external compression of fitting prostheses is very effective to avoid verrucous hyperplasia. Although verrucous hyperplasia of amputation stump is also termed lymphatic or stasis papillomatosis, there is a reported case without leg edema or enlarged lymph nodes due to prosthetic use. Gerbig and Hunziker reported verrucous skin lesions over the first metatarsal heads in a diabetic patient with neuropathy with a partial sensory loss on the feet and the distal lower legs. They had been unable to detect antigens of human papillomaviruses by means of immunohistochemical staining. Although the verrucous skin lesions were similar to verrucous carcinoma clinically, the histopathologic finding showed no cellular atypia. They described an entity similar to the verrucous skin lesions on the legs of leprosy patients. Srinvasan and Desikan reported cauliflowerlike skin lesions in neuropathic plantar ulcers in leprosy patients. Scheinfeld et al. did not state the association between verrucous hyperplasia and neuropathy. We suggest that peripheral nerve dysfunction attributed to amputation might also cause verrucous hyperplasia in relation to chronic pressure or friction.


AbstractThis paper describes a case study of developing and deploying a knowledge management system (KMS) in an organization. Knowledge Management (KM) initiative described in this paper is unique because it is being developed by using participatory approach by the Cross Functional Team (CFT). This paper describes a practical and systematic approach to conceptualization, development and deployment of KMS. The aim of this paper is to share the holistic view of KM initiatives and the steps taken to achieve the goal of KM development and deployment. The sharing the process of KM development and deployment would benefit organizations that are on the verge of starting KM initiative. The paper also interweaves practical approach with theoretical concept.


In this study, research status on radionuclide and colloid migration in underground research facilities including KURT (KAERI Underground Research Tunnel) was investigated. Some foreign underground research facilities constructed in crystalline rock formations such as granite were briefly introduced and compared. International joint researches concerned with the radionuclide and colloid migration were investigated particularly for the Grimsel Test Site (GTS) and sp Hard Rock Laboratory by analyzing major research items, on-going research projects, and future plans.


We obtained new book "Notes on Sound Absorption Technology". This book has been written by Professor K.U. Ingard. Professor K. Uno Ingard was educated at the Chalmers University of Technology in Gothenburg, Sweden and at the Massachusetts Institute of Technology in Cambridge, Massachusetts, USA. He received the Ph.D. degree in physics from MIT in 1950 and joined the MIT physics department as an assistant professor in 1952, having previously served as the Director of the Chalmers Acoustics Laboratory. He became an associate professor at MIT in 1956, a professor in 1966, and in 1971, he was appointed to a dual professorship in the department of aeronautics and astronautics. He taught acoustics and noise control engineering in the aeronautics department and has research interests ranging from aeroacoustics and nonlinear acoustics to structural vibrations and flow-induced instabilities.
He has worked on a wide variety of problems in acoustics and noise control engineering for more 45 years as a consultant to various industries. He is the author of several books, among them "Theoretical Acoustics", "Fundamentals of Waves and Vibrations", "Linear Acoustic theory", "Introduction to Mechanics", "Matter and Waves". He has authored more than l00 papers related to acoustics and the physics of fluids.


Ferrites such as (AxBy)FezO4 (doped spinel) or (AxBy)Fe1-x-yO (doped wustite) or their mixtures, where A and B are bivalent metal cations, were reported to be the most active materials for hydrogen generation using thermochemical watersplitting reactions. Although these ferrites have been synthesized by solid-state mixing, oxidation of aqueous metal hydroxide suspension, self-propagation high temperature synthesis and aerosol spray pyrolysis methods, the use of sol-gel derived ferrites for thermochemical water-splitting reactions is very limited. The sol-gel synthesis method provides better control over stoichiometry and powder characteristics. The powders produced by the sol-gel synthesis method usually have higher specific surface area, which may provide a higher number of active sites for water-splitting reactions. In this investigation, Sn-ferrite and Sn doped Ni-ferrite were synthesized using a sol-gel technique wherein Ni, Sn and Fe salts were dissolved in ethanol by sonication with the gel formation being accomplished by adding propylene oxide. The gels were aged for 48 h, dried at 100 o C for 1 h, and finally calcined at 900 o C in an air environment. The calcined powder was characterized using powder X-ray diffraction, BraunerEmmett-Teller surface area analysis and scanning electron microscopy. After the powder was placed in a packed bed reactor, the water-splitting reaction was carried out at 700 o C. After each water-splitting reaction, oxidized ferrite was regenerated at 900 o C for 2 h in an N2 environment. Synthesis method, characterization, and transient hydrogen profiles obtained at various experimental conditions will be presented in detail.


Aims: The aim of this study was to find & compare the pyloric Canal Length (CL), Pyloric muscle thickness (MT) by using the High Resolution Ultrasonography (HRUS) in Preoperative & postoperative period (after Ramstedt Pyloromyotomy) for Infantile Hypertrophic Pyloric Stenosis (IHPS). Methods: From January 2018 to June 2019, we have performed HRUS for 40 patients of clinically diagnosed cases of IHPS. & Ultrasonography machine: Phillips HD 7 machine & Alpinion E-CUBE with 3-12MHz linear probe, 3.5-5 MHz curvilinear probe and 5-7.5 MHz sector probe were used. The sonographic criteria for positive IHPS are Pyloric muscle thickness (MT) > 3 mm, pyloric Canal length (CL) >14 mm. Postoperative MT & CL at 2 month, 4 month & 6 month were determined and results were analysed with the preoperative pyloric parameters. Statistical analysis used: Mean and standard deviation of values were obtained by using Microsoft excel and statistical significance was analysed by regression study of grouped variables showing p – value by Microsoft excel. Results: Pyloric parameters (MT & CL ) gradually attain normal values over months and 80 % of patients showed resolution of pyloric MT & CL values by 6 months. MT assessment shows statistical significance at six months scan ( p- value <0.05). Conclusions: Serial postoperative HRUS in IHPS cases show gradual ( mostly by 6 months) resolution of pyloric parameters ( MT & CL ) to normal. MT appears to be a consistent parameter for serial assessment.


The preventive effects of polyvinylpyridine-N-oxide (PVPNO) on the experimental silicosis and toxic action of quartz particles to macrophages have been studied by Schlipkoter and others.1)-5) We recently found6) that very small amount of PVPNO (kindly supplied by Prof. Schlipkoter) inhibited the increase of acid phosphatase activity in macrophages induced by quartz particles. Nash, Allison and Harington7) published the paper on physicochemical


Gelatin/montmorillonite Cloisite 30 B (MMT) hybrid nanocomposites were prepared by blending gelatin with cloisite 30B in aqueous solution. The nano composites were characterized by using FTIR, SEM and XRD analysis. From the FTIR spectra the various groups present in the gelatin blend were monitored. The homogeneity, morphology and crystallinity of the blends were ascertained from SEM and XRD data, respectively . The results indicated that an intercalated or partially exfoliated nanocomposite could be achieved, and the properties of the composite were significantly improved.The drug release kinetics were investigated using Ofloxacin as the drug. The kinetics of the drug delivery system has been systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data vs. time by fitting to an exponential equation which indicated the non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of matrix.


The purpose of this work was to characterize and quantify phytophysiognomic units at mesoscale and evaluate their relationships with flood intensity, flood duration and topography. The study was conducted at a 25 km2 Long-Term Sampling Site (LTSS), located within the floodplain of the Cuiaba River in the Pantanal of Mato Grosso. The phytophysiognomic units were determined from the supervised classification of CBERS 2B sensor CCD satellite images. The maps of flood intensity, flood duration and of topography were generated from the spatial interpolation of planialtimetric field surveys. Four phytophysiognomic units were identified; Campo inundavel (flooded grassland) was the unit with the largest area of occurrence, followed by Cordilheiras (dense arboreal savanna), Landizal (seasonally flooded evergreen forest), and Cambarazal (monodominant Vochysia divergens Pohl. forest), respectively. Campo inundavel is distributed mainly in areas of high flood intensity and duration and low topographic positions. Cambarazal predominates in areas of medium flood intensity and duration and intermediate elevation, Landizal in areas of high flood intensity and duration and low topographic position, whereas Cordilheiras are characterized by low flood intensity and duration and location in higher elevations. Statistical tests indicated that flood intensity is the main factor responsible for the mesoscale distribution of phytophysiognomic units in the northern Pantanal.


In cloud storage, public key encryption with equality test (PKEET) is suitable for testing whether two ciphertexts generated from different public keys contain the same message without decryption. Recently, (Y. J. Wang et al., 2019) have proposed a public key signcryption scheme with designated equality test (PKS-DET). In this scheme, since the public key of the tester is used in the encryption, the tester needs to use its secret key to test the ciphertexts. Without trapdoor, PKS-DET prevents the attacker from testing the user's ciphertexts with the stolen trapdoor. Therefore, the privacy of the user can be protected. However, if the user in the PKS-DET wants to authorize the other tester to test his/her ciphertexts for some reason, the message needs to be encrypted again by the public key of the other tester. This will lead to higher computational complexity. Hence, the PKS-DET is not flexible to authorize multiple testers. In this article, we propose a construction of PKEET supporting flexible designated authorization (PKEET-FDA). The user in our PKEET-FDA can adaptively authorize multiple testers to test his/her ciphertexts, and each authorized tester must use its secret key to perform equality test for the ciphertexts. More importantly, the user does not need to encrypt the message repeatedly any more. We demonstrate the security of PKEET-FDA under two types of adversaries. Compared with the related efficient PKEET schemes, PKEET-FDA satisfies high efficiency from the point of view of the user. In terms of storage requirement, our construction is superior to the PKS-DET.


Neuromyelitis optica and its spectrum (NMOSD) are now recognized as being antibody-mediated conditions of the central nervous system. The antibodies are directed against aquaporin 4 water channels located on astrocyte foot processes, and their presence in the serum is associated with a relapsing phenotype. 1,2 NMOSD has a predilection for the optic nerves and spinal cord and is associated with a high morbidity and mortality. Disability is solely relapse related (in contrast to MS where disability is mainly accrued during the progressive phase) and many patients are left severely visually impaired or paraplegic, even after one attack. 3 Even prior to the discovery of the antibodies, when the disease was thought to be a variant of MS, patients were noted to be responsive to, and often treated with, immunosuppression. 4,5


The materials of this book represents the invited papers that were presented at the 6-th International Conference on "Mathematical Methods in Reliability: Theory, Methods, Applications", MMR'2009.


To solve the Cloze-style reading comprehension task, a challenging task to test the understanding and reasoning abilities of model, we propose a general and novel model called Fast Associative with Attention Memory Network in this paper. Unlike regular language model, we use fast weights to store associative memory for the recent past instead of activity hidden units which pay attention to the recent past. Our preliminary experiments indicate that our model outperforms regular RNN and LSTM. Keywords—Cloze Style, Fast Weights, Attention, Memory Network


In this paper we prove that for general memoryless binary input channels, most ensembles of parallel and serial turbo codes, with fixed component codes, are "good" in the sense that with maximum likelihood decoding, their word (or bit) error probability decreases to zero as the block length increases, provided the noise is below a finite threshold. Our proof uses the classical union bound, which shows that under very general conditions, if the noise is below a certain threshold, the word (or bit) error probability is controlled by the low-weight codewords as the block length approaches infinity. Our main coding theorems then follow from a study of the low weight terms in the ensemble weight enumerator. Using this methodology, we can prove that the threshold is finite for most ensembles of parallel and serial turbo codes.


argillite, interbedded basalt and abundant diabase sills. More specifically, the rhodonite is located above a section of grey, black and pale green chert and argillite at the base of the unit [IIPPvs( I ) on Figure 2-15-21 and about 50 metres below an upper section of brightly coloured, maroon, red, green and grey chert and argillite [Unit IIPPvs(2) on Figure 2-15-21, This stratigraphic position holds over at least 4 kilometres strike length, as shown by the two cross-sections in Figure 2-15-3. The immediate host of the rhodonite is well-bedded grey to pale green radiolarian chert with argillite partings. Geological Fieldwork 1989, Paper 1990-1 I-IPPvS " IIMvs 4


The aim of this paper is to offer a thematic study of Black British Literature. The analysis covers the way in which Black British writers have dealt with the issues of childhood, old age, history, return to the homeland, identity, language, and hybridity. Each of those questions is exemplified with a number of poems that show one or some of the perspectives from which they can be considered. The overall study thus constitutes a revision of an integral part of contemporary English Literature that works at destabilizing the idea that "pure" cultural identities exist and that homogeneous national literary traditions are possible.


vi Acknowledgments, v Approximability of the Green's Function with PML Boundary Condition, 112 Bibliography, 135 Conclusions and Future Work, 119 Dedication, iv Directional FMM for Maxwell's Equations, 3 Fast Algorithms for Boundary Integral Equations, 2 Introduction, 1 Preconditioners for Acoustics and Elasticity: Spectral Element Methods, 94 Preconditioners for Maxwell's Equations: Nedelec elements, 71 Preconditioners for Maxwell's Equations: Yee Grid, 50 Sweeping Preconditioners for TimeHarmonic Wave Equations, 49 Uncertainty Quantification for Acoustic Scattering, 32


saturated with either air N,, NzO, or NzO/Oz, were yirradiated in the presence and in the absence of formate. The residual activity of the enzyme in catalyzing the cleavage of the p-lactam ring of benzylpenicillin, was then monitored. The results indicate that in metalfree systems only the primary water-derived radicals, H, e,, and OH, contribute toward enzyme inactivation, while the secondary species 0; and CO; do not. The effect of copper(I1) ions on the radiation-induced damage depended on which of the active species was predominant. With OH radicals, no effect of copper was detected. The damage originating from e& and H radicals decreased with the addition of copper, presumably due to.their trapping by the copper(I1) ions. In contrast, with 0; radicals predominant in the system, copper dramatically enhanced the damage. This copper-induced sensitization was further increased in the presence of HzOz and the dose modifying factor of copper exceeded 100, ie. enhancement of the damage by two orders of magnitude, as compared with an oxygen enhancement ratio of 2-3 generally found for molecular oxygen. This copper effect could be completely eliminated by EDTA. The present results suggest that the presence of both transition metal ions and HzOz and the binding of the metal ions to the target bimolecules are required for the manifestation of the deleterious role of 0;. According to this model, the enhancement of the damage by copper results from the attack of reducing radical species on copper(I1) ions bound to the bimolecule. These protein-Cu(I1) complexes can be reduced by 0; radicals yielding protein-Cu(1) species, which in turn react with H202 to locally form secondary hydroxyl radicals that react, on that site, with the protein impairing its biological function.


Aim:To investigate the expressions of hypoxia-inducible factor-1α(HIF-1α) and connective tissue growth factor(CTGF) in peritoneum of peritoneal dialysis(PD) rats.Methods:Thirty-two male SD rats were randomly divided into four groups:normal control group,sham operation group,model group and PD group.Rats in model group and PD group were to make renal failure model.Six weeks after the model being successfully made,regular peritoneal dialysis in PD group was performed for 28 days.Then the protein and mRNA expressions of HIF-1α and CTGF were detected in peritoneal tissue of the 4 groups by the immunohistochemical staining and RT-PCR.The expression of alpha-smooth muscle actin(α-SMA) was detected.Results:There were significant differences in the expressions of HIF-1α protein and mRNA,CTGF protein and mRNA,and α-SMA protein among the 4 group(P0.001).Compared with those of the control group,the indexes mentioned above were higher in model group and PD group(P0.05),and the indexes mentioned above were higher in PD group than those in model group(P0.05).The expressions of HIF-1α,CTGF and α-SMA protein in the 4 groups were positively related to each other(P0.05).Conclusion:Peritoneal fibrosis in PD rats may be related to the upregulation of HIF-1α and CTGF expressions in peritoneum.


As is widely known and further documented here, Europe (the fi fteen EU members prior to the 2004 enlargement, hereafter the EU-15), has a lower standard of living than the United States as measured by PPPadjusted real GDP per person. This per capita real income shortfall, which has persisted for the last four decades, combines a defi cit both in output per hour and in hours per capita. This chapter asks whether Europe is really as poor as is suggested by comparative data on real GDP per capita. How much can the low Europe-to-United States (EU/ US) ratio of real GDP per capita be supplemented by a careful analysis that adds to European welfare the value of leisure implied by shorter work hours, as well as subtracting components of US GDP that do not represent higher welfare. The position that Europe has simply chosen equal-valued leisure hours over work hours is most strongly proposed by Blanchard (2004: 4), who writes that "The main difference is that Europe has used some of the increase in productivity to increase leisure rather than income, while the United States has done the opposite." An alternative interpretation is that the rise in the EU/US productivity ratio was artifi cial, as Europe made labor expensive through high labor taxes, high minimum wages, and tight labor and product market regulations. As a result fi rms were forced to slide northwest up their labor demand curves, retaining high-productivity workers while forcing low-productivity workers into unemployment or out of the labor force entirely. Under this interpretation the decline in hours per capita is largely involuntary and does not represent unmeasured welfare. The "unmeasured leisure" hypothesis has only a grain of truth and fails for three reasons. First, many of those "not-worked" hours Controversies about Work, Leisure, and Welfare in Europe and the United States


This study was conducted in a water flow-through tank to evaluate the effects of dietary fish meal(FM) replacement by mixture of soybean meal(SBM) and rapeseed meal(RSM) on digestive enzyme ac-tivities and apparent digestibility of black carp(Mylopharyngodon piceus).A typical diet with 38% crude pro-tein level(fishmeal protein: plant protein =1:1) was used as the control(Diet A).The other experimental diets(Diets B-E) in which 25%,50%,75% and 100% of fishmeal protein were replaced by mixture of soybean meal and rapeseed meal(SBM: RSM =1:1) respectively.Five triplicate groups of fish were fed the isocaloric(13.3 kJ/g feed energy) and isonitrogenous(38% crude protein) diets three times per day at 5% of fish body weight for 8 weeks,and each experimental group was stocked with 20 fish [initial average weight of(10.45 ± 0.85) g].The apparent digestibility of formulated diets was estimated based on feces analysis of the black carp in laboratory.The results showed that the protease activity in intestine and hepatopancreas of diet A,diet B and diet C was significantly higher than those of diet E(P0.05),but no significant difference was found among three diets(P0.05).There was no significant difference for amylase activity in intestine and hepatopancreas of black carp in five different experimental groups(P0.05).Apparent digestibility of protein、lipid and dry matter were not changed significantly(P0.05) among diet A、diet B and diet C,but the apparent digestibility were reduced sig-nificantly as the proportion of plant protein in the diets continually increased.The results indicated that dietary fish meal(FM) protein replacement by 25%-50% mixture protein of soybean meal(SBM) and rapeseed meal (RSM) caused no significant effect on the digestive enzyme activity and apparent digestibility of black carp.


Hemophilia is an X-linked recessive genetic disorder in which the body has an inability to clot, leading to increased risk of mortality for individuals if a bleeding episode were to occur. Traditional hemophilia treatments such as prophylactic factor replacement therapy of recombinant factor VIII and IX, have been proven to be costly and do not provide a long-lasting protection during bleeding episodes.(1) In recent years, use of Adeno-associated viral vectors (AAV) gene therapy has been explored as a potential alternative due to efficient gene delivery and tissue tropism, overall safety and efficacy, and longer-lasting effects.(2) However, concerns over inhibitor development still stands as a majorly significant treatment complication that burdens the steady progression of long-term treatment. This review article seeks to provide an overview of the current state of AAV-based gene therapy as a treatment for Hemophilia.


Based on vapor-phase transport method, manganese-doped zinc oxide (ZnO:Mn) tetropod whiskers were fabricated. The pods of the ZnO:Mn whiskers show hexagonal hollow shape with multitips at the front. X-ray diffraction and high-resolution transmission electron microscopy demonstrate that the tube pods and the tips are composed of wurtzite ZnO growing along [0001] direction. The generation of the luminescent center in ZnO whiskers and electron transport between the ground state and the excitation states of Mn2+ are analyzed by Raman-scattering, photoluminescence, and photoluminescent excitation measurements.


The problem of Mingjiao and Ziran is a basic problem for the intellectual in the Chinese feudal time. This problem involves connection between the intellectual's individual freedom and the collective system. From the angle of philosophy, GUO Xiang was the first who solved the problem. Then, Huineng further consolidated the result, which had profound influence on the intellectual's mentality and their life style. This life style made an important influence on Chinese Aesthetics.


Interference method of testing the long-focus focusing lenses allows measuring such optical parameters as focal distances and distortions of wavefront passing through the lens. High measurement accuracy is achieved by means of a special laser measurement system (laser tracker) in autocollimation schematic based on dynamic interferometer. Main sources of instrument error were found out and their relation to the measurement schematic parameters was defined. The article shows that the method allows achieving total instrument measurement error of the 0.003% of the value being measured.


Medulloblastoma (MB) is the most common malignant pediatric brain tumor. The most aggressive MB subtype Group 3, is characterized by Myc amplifications. However, targeting Myc has proven unsuccessful, necessitating alternative therapies for MB. The histone methyltransferase, enhancer of zeste homolog 2 (EZH2), is well-known for its role in catalyzing the tri-methylation of H3K27 (H3K27me3). Recent studies have demonstrated that EZH2 is overexpressed in Group 3 MB and that Myc and EZH2 regulate the expression of the B7 homolog 3 (B7-H3). As we previously showed the oncogenic functions of B7-H3 in Group 3 MB, this study aims to investigate the efficacy of EZH2 inhibition to reduce B7-H3 levels in an effort to improve treatment options and patient survival. Datamining studies conducted using MB patient datasets showed a positive correlation between EZH2 and B7-H3 transcripts. Additionally, we showed that inhibition of EZH2 using EPZ005687 in Myc-amplified MB cell lines downregulated B7-H3 and Myc expression. Furthermore, targeting EZH2 through shRNA and pharmacological inhibition reduced the viability and augmented apoptosis, as indicated by LDH, MTT, clonogenic, and FACS assays. We additionally tested the consequences of EZH2 inhibition on the C17.2, murine neural stem cells, and C17.2 NSC transformed with EZH2 oncogene (C17.2_EZH2OX). Furthermore, the C17.2_EZH2OXcells were susceptible to EPZ005687 treatment compared to C17.2 control cells, as demonstrated by MTT and FACS. Collectively, our study highlights the therapeutic benefits of targeting EZH2 in Myc-amplified MB cell survival.
 Citation Format: Katherine Shishido, Sujatha Venkataraman, Rajeev Vibhakar, Kiran Velpula, Swapna Asuthkar. EZH2 inhibition targets B7-H3 in Myc amplified medulloblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5667.


PURPOSE: To minimize the lock and read of a physically or logically empty data page by reading the page of a physical storage space storing the conditions of the respective pages separately from the page and inserting data to the page. CONSTITUTION: The conditions of the respective data pages are stored in a segment control block 20 as a page condition label 26 independent of the page 18 itself. A condition instruction 'full' is set when the data can not be added any more to the page 18. During a read operation, the pages are locked first and then read. The condition instruction 'massive elimination' 26d is set when the page 18 becomes logically empty by a massive elimination operation. Then, the page condition label 26 of the segment control block 20 is changed to the condition instruction 'massive elimination' 26d. During an insertion operation, the page of 'massive elimination' is not read first since only the data for abandonment are provided.