An electron capture detector (ECD) is described that responds sensitively to trace levels of iodinated hydrocarbons but does not respond to chlorinated hydrocarbons (ClHCs). These response characteristics have been achieved through control of four gas-phase processes: dissociative electron capture (EC) by the halogenated hydrocarbons, the regeneration of an EC-active species (thought to be HI) by the recombination of I{sup {minus}} with positive ions, the photodetachment (PD) of I{sup {minus}}, and the prevention of PD of Cl{sup {minus}} by the clustering of this negative ion by water molecules. This photodetachment-modulated electron capture detector (PDM-ECD) is instrumentally simpler than an earlier version. Its light source is a low-power Hg arc lamp and requires no associated monochromator or light filters. The application of this instrument to the specific detection of methyl and ethyl iodide in an air sample that contains an excess of ClHCs is demonstrated. The device is also shown to hold considerable promise for the selective detection of brominated hydrocarbons in the presence of ClHCs.


The move towards international harmonization of accounting standards has dominated the work program of International Accounting Standards Board (IASB) in the past years. This paper aims to verify the compliance of the comprehensive income (CI) statement format with International Accounting Standard (IAS) 1⎯presentation of financial statements, which was revised in 2007. The changes introduced by the 2011 revision are also taken into account. For this purpose, this study analyzes the final annual financial statements approved in 2011 by the Italian companies whose shares belonged to the Italia Star segment of Financial Times and Stock Exchange (FTSE). Given that IAS 1 provides little specific guidance about the presentation of line items and permits many alternative types of format, this paper focuses on information organization in the statement of CI in order to analyze the degree of heterogeneity of financial information. For achieving this goal, this study considers the following issues: (1) presentation of all items of income and expense in an overall statement or in two separate statements; (2) a detailed level of the content in terms of number of items between revenue and net income (NI); (3) classification of expenses either by nature or by function; (4) number and type of intermediate margins; and (5) presentation of items of other comprehensive income (OCI) either before tax or net of tax. The results show some clear evidences. On the one hand, there is a high diversity in accounting practices, which makes it difficult for users to compare financial information across entities, highlighting the need to complete the joint project of the standards setters (IASB and Financial Accounting Standards Board (FASB)) on financial statement presentation. On the other hand, some alternative types of presentation (e.g., the tendency to split the CI statement into two statements rather than using an integrated solution, the prevalence to disaggregate the expenses by nature, etc.) are used by most of the entities of the sample possibly because of the influence of Italian accounting culture.


(57) Abstract: Method for removing material from the Generating a plasma in a sapphire plasma tube comprises a plasma generator and the discharge device. At least one fluorine-containing compound is introduced into the plasma. The forming gas is introduced into the plasma. Directing toward the material to be removed the plasma from the substrate.


Cloud based services known as "Software as a Service" has in the past few
years become very popular in the IT industry. Hence it is not surprising that
the concept also has reached the security industry and the market for camera
surveillance, where the concept "Video Surveillance as a Service" (VSaaS) has
become a buzzword. This is much because of new business opportunities for
the vendors and easier camera management for the customer. Axis
Communications AB is the world-leading provider of network based camera
surveillance has entered this market with their service Axis Video Hosting
System (AVHS).
Problem definition:
There are good reasons to believe that VSaaS has the potential of being a
successful commercial service. But yet the growth of this market has not
reached the hopes of the industry.
This means that there is a resistance among the end customers to embrace and
pay for the concept of video surveillance as a service. Another key factor for
VSaaS to be successful is for all the participants in the value system that
together creates the VSaaS service to overcome any barriers.
Is it simply the price that the end customer sees as an issue or can it be that the
service lacks any functionality, or that the existing functionality does not match
the needs of the end customer? And which barriers in the value chain are there
to be overcome, and what possibilities are there to solve these barriers?
Delimitations:
To create the VSaaS service physical hardware needs to be connected to
software, and then packaged to a final service that can be delivered and
installed to the end customer. The decision of what which each part of the
value chain will contribute with will follow Axis' current business model. This
master thesis does not aim to quantify how much the end customers are willing
to pay or to look at the profitability. End customers are restricted to retail.
V
Purpose:
The purpose with this master thesis is to examine the driving forces behind the
incentives to pay for this service among all the parties in the value chain as well
as the end customer.
Method:
This master thesis is conducted as a case study at Axis Communications AB.
The study is based on internal documentation and qualitative internal and
external interviews with different stakeholders involved in delivering VSaaS to
an end-user.
Thesis conclusions:
According to the theory the incentives to pay could be described as the
perceived value of a good or service. Since VSaaS is combined effort by several
parties in ecosystem every member of that system must also see their benefit to
embrace the service.
Response from the interviewees revealed that there exist several barriers both
for end customers to buy VSaaS and VSP's willingness to sell it, and for them
to accept the idea of selling surveillance as a service. The main barriers are for
end customers to accept to pay for video surveillance as a service,
infrastructure, lack the need of advanced functionality, and that some VSP's
prefer to sell other products with better margins.
Further a price analysis revealed that the price is a problem in the low-end
segment of the market, but is in line with or below similar solutions sold by
system integrators. The conclusion of this is that the price alone is not an issue.
The conclusion is thus that the price or a specific feature alone is not what will
determine the end customer's incentive to pay for this service. Instead there
are several factors that affects each other, and across the whole ecosystem.


A method for producing a wash-resistant bond between a water-impermeable and water vapor permeable foil on Copolyetheresterbasis (d) and at least one substrate (a) based on polyester of a woven or knitted fabric, to obtain a single variety textile composite having a resistance to washing at 60 ° C at least five times wash, characterized in that prior to bonding with the substrate (a) the water-impermeable and water vapor permeable foil on Copolyetheresterbasis (d) with at least one co-polyester film from a hot-melt adhesive based on hydrophilic copolyetherester (c) to form a laminate (e) is processed, and this laminate (e ) with the substrate (a) bonded by means of a hot melt adhesive copolyester (b) which has a maximum use temperature of 140 ° C, using as Copolyesterteil the film (c) or as zulaminierte copolyester film (c) selecting a sheet of a hot-melt adhesive having a melting point of 90-190 ° C based on hydrophilic copolyetheresters, wherein as building blocks for this copolyetherester, terephthalic acid is used as the sole acid component and their molar fraction, based on the ...


The elastic modulus and the tensile strength of uniaxially pressed alumina-kaolin green bodies were measured using noncontact ultrasound and diametral compression, respectively. These properties showed a strong dependence on the green density and, therefore, the compaction stress. The dependence on density was compared with theoretical models and these did not accurately describe the observed behavior. Possible causes of the discrepancies with the theoretical derivations are discussed. The choice of binder was shown to play a critical role in determining the elastic modulus, strength, strength variability, and fracture morphology.


Harnessing a patient's immune system by attenuating endogenous immune checkpoints on T-cells has led to dramatic, durable tumor rejection for multiple tumor types. Nonetheless, many cancers, including pancreatic ductal adenocarcinoma (PDAC), still do not respond to immunotherapy. PDAC remains largely resistant to all therapies, leading to its notoriety as one of the most lethal malignancies, with a 6% 5-year survival rate. We aimed to find novel, targetable mechanisms by which tumors escape the adaptive immune system and resist immunotherapy. We conducted a high throughput screen of 1280 compounds producing a synergistic effect with T-cell killing to assess differences and similarities among distinct pathways inclusive between PDAC and melanoma. These screens identified several aurora kinase inhibitors as synergistic with autologous T-cell killing of tumor target. Here we present results underlying the mechanism by which aurora kinase inhibition enhances autologous T-cell mediated killing and may improve T-cell-mediated cancer immunotherapy. These findings may contribute to the design of new therapeutic combination strategies for enhancing immunotherapy treatment of melanoma, PDAC, and other "immunologically cold" tumors. Note: This abstract was not presented at the meeting. Citation Format: Emily L. Ashkin, Deborah Silverman, Simone Punt, Soraya Zorro Manrique, Leila Williams, Yunfei Wang, Patrick Hwu. A novel compound screen for enhancing T-cell based immunotherapy identifies aurora kinases as a targetable mechanism for tumor immune escape in pancreatic ductal adenocarcinoma preclinical models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3956.


This article discusses the advantages of using innovative and communicative information technology, which are the main factor in improving the quality of education and foreign language instruction. This article explores current issues of the use of information technology in teaching a foreign language. The introduction of new information technology in the educational process and in teaching a foreign language is an urgent requirement of today. This technology supposes using not only the most modern technical equipment, new forms and methods of teaching, but also a completely new approach to the teaching process, which helps to implement the principle of interactive, communicative-based teaching and provides individualization and differentiation based on features of trainees, their level and inclination.


The invention discloses a preparation method of phenyl silicon resin, and the preparation method comprises the following steps of: dropping acetone and water mixed hydrolysate to a dimethylbenzene and acetone mixed solvent under an ice-water mixed bath by taking phenyl trichlorosilane and diphenyl dichlorosilane as monomers and adopting an inverse hydrolysis method; after the acetone and water mixed hydrolysate is completely dropped, continuing to react under the ice-water mixed bath till hydrolysis is finished; standing, layering to obtain lower acid water, washing the upper hydrolysate to be neutral by using hot distilled water to obtain a phenyl silicon resin prepolymer; then adding a certain amount of condensation catalysts for condensation reaction; after the reaction is finished, washing the condensation catalysts to be neutral by using the hot distilled water; and then distilling solvent dimethylbenzene under the condition of decompression till no dimethylbenzene is positioned in a system to obtain a phenyl silicon resin product. The phenyl silicon resin prepared through the method disclosed by the invention is a rigid and transparent massive solid, has the advantages of better product uniformity, good high temperature resistance and solubility, and the like; and the method disclosed by the invention has the advantages of simple processing condition, solvent recycling and easiness for industrialized production.


Purpose – The purpose of this paper is to propose a methodology with systematic metrics for logistics service providers (LSPs) to develop their environmental sustainability performance in the context of green supply chain management. Design/methodology/approach – An integrated analytical approach which combines analytical network process (ANP) with quality function deployment (QFD) is proposed to develop LSPs' environmental sustainability performance. In the approach, QFD is used to translate customer requirements (CRs) for "green" concerns into multiple criteria for LSP's design requirements (DRs). ANP is used to analyze the inter-relationships among the various CRs and DRs. Findings – The effectiveness of the proposed approach is demonstrated by applying it to a global LSP. A case study shows how the proposed "ANP-QFD" technique can be deployed to understand customers' expectation for environment management and develop tactics and measures with the aim to achieve the desirable outcome for LSPs' environm...


Cardiac resynchronization therapy indications and management are well described in adults. Echocardiography (ECHO) has been used to optimize mechanical synchrony in these patients; however, there are issues with reproducibility and time intensity. Pediatric patients add challenges, with diverse substrates and limited capacity for cooperation. Electrocardiographic (ECG) methods to assess electrical synchrony are expeditious but have not been extensively studied in children. We sought to compare ECHO and ECG CRT optimization in children.


Insolation onto and energy output from solar collectors have been estimated for some typical high latitude locations using the F-Chart computer program and weather data from the Swedish Meteorologi ...


Summary  The individual and interactive effects of four production factors (amount of vegetable rennet, temperature of coagulation, pressing and salting of the fresh cheese) and two ripening factors (temperature and relative humidity) on microbiological, physico-chemical, biochemical, textural and sensory characteristics of Serra cheese were simultaneously studied using a 2vi6-1 factorial design. Highly significant effects of salting and ripening relative humidity upon the characteristics of the cheese were detected. Addition of salt to the surface of the fresh cheese reduced microbial growth, water activity, moisture and lactic acid contents, proteolysis, lipolysis, aroma and softness of the cheese. Conversely, increase of the relative humidity during ripening increased these charactereristics. Pressing had no statistically significant effect on cheese characteristics.


The information content of (photospheric) stellar spectra and the accuracy of abundance determinations are discussed. Besides the physical properties of the line spectra, the spectral resolution, the signal-to-noise ratio, but also the incompleteness of the knowledge of the contributing blends limit the abundance information. For a perfect model atmosphere the main factors determining the accuracy of the abundances are S/N, the line saturation, and the location of the continuum (or, in a synthetic spectrum, the background of numerous lines). In addition systematic errors introduced by missing atomic data and an imperfect model atmosphere (non-LTE, line blanketing, hydrodynamics) are important. The typical accuracy of abundance determinations is discussed for main sequence stars for which the most reliable data are available, and for a few selected other stellar types.


In recent years, event tourism has become an important part in city tourist attraction when there is an increasing competitive tourism. Event tourism caused concern in many areas, however, issues related to driving factors is rare at home and abroad, and there is no quantitative studies and application of mathematical methods. Based on the development of 9 driving factors at given urban event and taken 19 cities in China as example, using quantitative methods to analyze the difference of urban event tourism driving factor in different region provide a reference for future urban development.


With the reform of personnel system in higher education institutions,especially during the implementation of college teachers' appointment systems,we have seen the(increasing) urgency and importance of teachers' performance assessment system to be established according to idea of modern human resource management.Thereby this paper will focus on the transition from traditional assessment system into performance assessment and the related problems.


Narrowband Single-Longitudinal-Mode (SLM) lasers are important in a number of applications, including frequency metrology, LIDAR, nonlinear optics, holography, and in optical fiber communications. In recent years, the need for such devices has been embraced by the US Navy, who seek low amplitude and phase-noise devices to enhance low noise-figure RF photonic capabilities for avionic and electronic warfare (EW) applications.


According to recent status faced with work-pieces machining of railway vehicle,this paper made use of Power Mill software to create machining program and demonstrated the feasibility and applying foreground of the software in the industry of railway machining.


This paper proposes an audio information hiding algorithm based on BP neural network. The algorithm adopts 256 grey scales image as embedded information and audio as the carrier. Utilize learning samples to train the neural network, and then extract image information by the trained network. The advantages of this algorithm are as follows: a great deal of data can be hided, the time of extracting data is short, the anti-attack robustness is strong, etc.


In offshore petroleum exploration, subsea systems are susceptible to a variety of undesirable events or faults, in which oil wells operation is considered abnormal. Proper detection and classification of such events is crucial in order to reduce downtime, maintenance costs, and even damage to installations. Flow instability is a type of event inherently related to hydrocarbon multiphase flow and root cause of equipment stress and failure. This work investigates applying binary machine learning classifiers on real world captured data for the task of flow instability fault detection. Four different evaluation scenarios were considered. The mostly common scenarios used by the machine learning research community showed that even simple algorithms can reach high classification performance. The remaining scenarios, however, try to avoid the similarity bias problem and showed more realistic results.


Background and Purpose— Spasticity is a disabling complication of stroke and different noninvasive treatments are used to reduce muscle hypertonia. Shock waves are defined as a sequence of single sonic pulses largely used in the treatment of diseases involving bone and tendon as well as muscular contractures. The effect and duration of extracorporeal shock wave therapy (ESWT) was investigated on muscle hypertonia of the hand and wrist. Methods— A total of 20 patients affected by stroke associated with severe hypertonia in upper limbs were evaluated. Placebo stimulation was performed 1 week before active stimulation in each patient. Evaluation was performed using the National Institutes of Health and Ashworth scales and video monitoring with a digital goniometer before and immediately after placebo or active stimulation. Motor nerve conduction velocity from abductor digiti minimi were recorded. Patients were monitored at 1, 4, and 12 weeks after active treatment. Results— After active ESWT, patients showed greater improvement in flexor tone of wrist and fingers compared with placebo stimulation. At the 1- and 4-week follow-up visits, a significant decrease of passive muscle tonicity was noted on muscles in all patients receiving active treatment. At 12 weeks after therapy, 10 of the 20 patients showed persistent reduction in muscle tone. There were no adverse events associated with ESWT. Conclusions— ESWT reduces hypertonia of the wrist and finger muscles for ≥12 weeks after treatment. The possible mechanisms of action of ESWT are discussed.


Mammography is currently the gold standard technique for early detection of breast cancer before it becomes clinically palpable. Breast compression is essential part of mammography which provides better contrast and smaller radiation dose. It optimizes the image quality and the visualization of small lesions by reducing the breast thickness. The overall goal of this thesis is to simulate the complete mammographic imaging chain, starting from the creation of breast phantoms, compression, and mammogram simulation. A specific aim is to carry out a study that compares the quality of breast lesions on simulated mammographic images obtained from both uncompressed and compressed breast models. For the creation of the breast models, we use a software breast phantom which incorporates a 3D voxel array with geometric primitives, a ductal network, and a model for lesions. Further on, a Simulation Algorithm for Soft Tissue Compression (SASTC) is used for the compression of the breast phantoms. For this purpose, the algorithm was implemented into C++ language and incorporated into the available Breast Simulator software. The SASTC algorithm is based on the spring-mass model according to which the volume of the breast phantom is divided into a number of elements, each one consisting of 27 nodes and the nodes are connected with springs. The compression algorithm allows stretching and compression of the volume object. Due to these deformations the voxels of the breast's volume are distorted. Several algorithms are developed to correct for these distortions. These algorithms are based on interpolation techniques and on the Jordan Curve Theorem. We designed 11 models of small breast phantoms that included microcalcifications of different sizes. These breast phantoms as well as the compressed model of each phantom are subjected to mammography simulation to create mammograms. The x-ray image acquisition model, used for the acquirement of the mammographic images, is based on a combination of ray tracing techniques and the x-ray attenuation law. A comparison between the acquired mammograms of both uncompressed and compressed breast phantom was performed. A preliminary visual evaluation demonstrates that the clarity of


The knowledge of the refractive index of liquids is of major importance in many application fields and therefore several methods have been proposed to achieve high precision and accuracy. Although most methods can in principle be used both in the visible and in outer ranges (e g. in the infrared), they have typically been tested only in the visible, mainly due to experimental difficulties, and values in the infrared have been obtained by extrapolation.


we present a large heterogenously enhancing, well defined, lobulated multilocular cystic lesion seen involving           abdominal wall. Biopsy followed by total resection of the lesion showed a spindle cell sarcoma with hemangiopericytomatous pattern, which was consistent with monophasic synovial           sarcoma on histology and immunohistochemistry. The unusual clinical presentation, radiology, pathology and differential             diagnosis will be discussed in detail.


To study the best process conditions for preparing ultrasonic lincomycin β-cyclodextrin inclusion. Method: Choose the usage ration of Lincomycin hydrochloride with β-cyclodextrin, the inclusion temperature and the time of reaction as the main factors, and use the inclusion yield as evaluated indicators and the process condition to conduct the L9 (3) orthogonal experiment Optimization Pack lincomycin hydrochloride. Outcome: The optimum inclusion process condition: molar ratio of the Lincomycin hydrochloride with β-cyclodextrin is 1:3, inclusion temperature is 30°C , inclusion time is 80 minutes. And use infrared spectrophotometry, microscopy imaging to identify the lincomycin hydrochloride β-cyclodextrin inclusion complex has been formed.Conclusion: The process condition of using β-cyclodextrin inclusion to inconcluse lincomycin hydrochloride is feasible, effective, and of applicative value.


5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and dose-limiting toxicities, diverse 5-FU prodrugs have been developed to confer oral bioavailability and increase the safety profile of 5-FU chemotherapy regimens. Our contribution to this goal is presented herein with the development of a novel palladium-activated prodrug designed to evade the metabolic machinery responsible for 5-FU anabolic activation and catabolic processing. The new prodrug is completely innocuous to cells and highly resistant to metabolization by primary hepatocytes and liver S9 fractions (the main metabolic route for 5-FU degradation), whereas it is rapidly converted into 5-FU in the presence of a palladium (Pd) source. In vivo pharmokinetic analysis shows the prodrug is rapidly and completely absorbed after oral administration and exhibits a longer half-life than 5-FU. In vivo efficacy studies in a xenograft colon cancer model served to prove, for the first time, that orally administered prodrugs can be locally converted to active drugs by intratumorally inserted Pd implants.


We examine the spatial and temporal relationship between coronal structures observed with the soft X-ray telescope (SXT) on board the Yohkoh spacecraft and the vertical electric current density derived from photospheric vector magnetograms obtained using the Stokes Polarimeter at the Mees Solar Observatory. We focus on a single active region: AR 6952 which we observed on 7 days during 1991 December. For 11 independent maps of the vertical electric current density co-aligned with non-flaring X-ray images, we search for a morphological relationship between sites of high vertical current density in the photosphere and enhanced X-ray emission in the overlying corona. We find no compelling spatial or temporal correlation between the sites of vertical current and the bright X-ray structures in this active region.


Polyurethane based sealants are widely used in a variety of structural and construction applications. The purpose of this project is to evaluate what if any degradation of the mechanical properties of a selection of Polyurethane based sealants occurs when exposed to a variety of environmental stimuli. This project will explore and critically compare the results of mechanical testing using the Shimadzu TensileCompressive testing apparatus and provide clear guidance on what environmental stimuli pose the greatest risk to the maintenance of the mechanical properties of the sealant.


OBJECTIVE
To determine morbidity and mortality from cholera during different segments of the period 1991-2011 in the countries of Latin America.

METHODS
Using information sources from a nonsystematic literature search for works on cholera epidemics, a mixed ecological study was conducted aimed at a time series analysis of morbidity, mortality, and case-fatality in cholera-related health events between 1991 and 2011 in 18 Latin American countries.

RESULTS
During the period 1991-2011, 1 839 037 cases of cholera were reported in Latin America, with 19 538 deaths and a case fatality rate of 1.06%. The most affected countries were Peru between 1991 and 2002-with a maximum annual cumulative incidence of 1 452.72 cases per 100 000 population but a low case fatality rate (0.72%)-and Haiti between 2010 and 2011, with a maximum annual cumulative incidence of 3 319.13 per 100 000 population and a case fatality rate of 1.32%.

CONCLUSIONS
The cholera epidemic has resulted in high morbidity, mortality, and case fatality in some Latin American countries, due largely to basically socioeconomic and climatic factors. The reemergence of this disease and the many factors related to how cholera outbreaks evolve call for the development and strengthening of regional prevention and control strategies in the countries as well as a study on the determinants that influence the emergence and reemergence of infectious diseases in Latin America.


Introduction and Background On February 27th 2017, the World Health Organization (WHO) published a list of the top twelve resistant bacteria that greatly endanger human health (Press Association, 2017). Drug resistant and multi-drug resistant bacteria are one of the most serious public health threats the world faces today. Antibacterial resistance is the ability of bacteria to survive even in the presence of antibiotics. The development of antibiotics has made a great impact on the medical field by enabling doctors and health professionals to successfully combat many diseases. However, with the rise of the use of antibiotics, drug resistance has evolved, and according to WHO statistics, 700,000 people die annually from infections and diseases that have resulted from such resistant bacteria (Press Association, 2017).


To examine the extent to which receipt of recommended monitoring of diabetes mellitus (DM) differed for participants with and without comorbid dementia, as well as the effect of other comorbidities on monitoring of DM in individuals with comorbid dementia.


Renal cell carcinoma (RCC) is the 7th most common type of cancer, with over 400,000 new cases each year and 170,000 deaths worldwide. RCCs are grouped into several histological subtypes, with clear cell renal cell carcinoma (ccRCC) being the most common and most aggressive type. The first line of therapy for ccRCC is tyrosine kinase inhibitors (TKIs) which target multiple kinases including the VEGF receptor. The treatment can be used alone or in combination with immune checkpoint inhibitors. However, most patients develop resistance to the TKIs within six months of treatment. Therefore, our aim is to develop novel single or combinatorial therapies and discover ways to overcome the resistance to TKIs. By analyzing TCGA and published datasets from GEO, we found that angiopoietin-like 4 (ANGPTL4) is significantly elevated in both the WT and TKI-resistant ccRCC tumors. ANGPTL4 has been shown to participate in angiogenesis in several other tumor models, and blocking ANGPTL4 with an antibody in vitro, reduces the angiogenic potential of 786-O and RCC4 human ccRCC cell lines, suggesting a pro-angiogenic effect of ANGPTL4 in ccRCC. Knockout of ANGPTL4 in Caki-1 xenograft tumor model significantly reduced tumor angiogenesis and increased vessel normalization, as evidenced by increased expression of VEGFR2 and adhesion molecules on endothelial cells. The increased normalization of blood vessels is an indication of the therapeutic potential of combing anti-ANGPTL4 therapy with immune checkpoint inhibitors. Furthermore, both knockout of ANGPTL4 in 786-O cells and treatment of 786-O tumor-bearing mice with an ANGPTL4 blocking antibody significantly reduced tumor growth. To illustrate the mechanism of ANGPTL4-induced angiogenesis, we performed live cell receptor capturing to find cANGPTL4 binding partners on the cell membrane of human endothelial cells. After the mass spectrometry analysis, several novel receptors were found, and the top candidate is endothelial cell surface chemotaxis receptor (ECSCR), which is highly expressed on endothelial and adipocytes. Previous studies have shown that ECSCR can potentiate angiogenic signaling, which is similar to our data showing that ANGPTL4 can synergistically increase FGF2-induced angiogenesis. Thus, ANGPTL4 may promote angiogenesis in ccRCC by potentiating other angiogenic signaling via interaction with ECSCR. To summarize, we demonstrated the pro-angiogenic potential of ANGPTL4 in ccRCC and its critical role in tumor development. Knockout or antibody-mediated inhibition of ANGPTL4 reduced tumor angiogenesis and growth and increased vessel normalization. This data supports the therapeutic potential of ANGPTL4 targeted treatment in ccRCC.
 Citation Format: Zeng Jin, Umasankar De, Lei Wang, Jeremy Kleberg, Weizhou Zhang, Ryan Kolb. Angiopoietin-like 4 as a potential therapeutic target for clear cell renal carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 571.


This research was conducted with the intention or purpose of describing human resource management and the problems that occur in the midst of a high level of rivalry, as well as making alternative strategies for CV. Ajib Bio Syifa is a bottled beverage water company located on the island of Lombok. HR is very important to be developed because HR is one of the distinguishing factors between each company. In this research, the research method used descriptive qualitative. While collecting data by making observations and interviews. In order to test the validity of the data, the authors used a triangulation technique. Based on the research results, it can be seen that the company's HR management has been implemented. Because the company has effectively compiled the planning of human resource needs,
organizing, and actuating workers. So as to achieve high employee motivation.


The automatic beam superposition properties of the Wollaston prism are used to develop comparison beam systems for the simultaneous optical measurement of one, two and three components of the velocity vector in fluids. The systems do not require beam alignment for heterodyning, thus removing a traditional disadvantage of comparison beam systems compared with cross-beam systems and permitting full use of the fact that comparison beam systems are inherently better suited for multidimensional velocity measurement than cross-beam systems. The systems discussed use photodiodes (having one or more photosensitive areas) without preamplification. No electronic or optical high, low or narrow pass filters are used.


When the decision to initiate a software product line has been taken, the first step is the domain analysis describing the variability in the requirements, the second important step is the definition of a domain architecture that captures the overall structure of a series of closely related products. A domain architecture can be a core asset in product line by describing the commonalities and variabilities of the products contained in the software product line. The variabilities, which are identified at each phase of the core assets development, are diverse in the level of abstraction. Therefore, it is important to clearly define, systematically identify, and explicitly represent variability at the architectural level. However, it is difficult to identify and represent the variability which should be considered at the architecture level, because these may be appeared in architecture elements and in architecture configuration. In this paper, we suggest a method of developing domain architecture as a core asset in product line where commonality and variability are explicitly considered. First of all, we will describe a domain architecture metamodel that can explicitly define commonality and variability concepts by extending the Object Management Group's ( Reusable Asset Specification eRAS) model. Using the domain architecture metamodel, architecture elements are defined and the variations that can be identified at the architecture level are classified into two types in according th abstract level. Additionally, we describe a domain architecture where commonality and variability are explicitly considered on basis of this metamodel.


The increasing demand for electricity offers many opportunities for renewable energy production, of which one alternative is tidal stream energy. Several feasibility studies have shown that the global tidal stream energy potential can contribute significantly to producing renewable energy. This tidal energy can mostly be produced at the 'tidal hotspots', where the kinetic energy density is very high due to fast flowing tidal currents. However, the tidal technology is not yet cost competitive in comparison with other renewables, such as photovoltaic and wind energy, which is why further cost reductions and efficiency improvements are to be achieved. Interviews with existing tidal system developers provided insight in the cost breakdown and showed that maintenance accounts for a significant share of the total project costs. This is due to the harsh environmental conditions that impose a large uncertainty, which increase the complexity of selecting an optimal maintenance policy. Damen Shipyards has shown interest in entering the tidal industry and is exploring the cost reduction possibilities by developing their own tidal system. This thesis contributes to Damen Shipyards' research by performing a time series analysis of a tidal hotspot to identify and model the multivariate dependence of the governing environmental phenomena. A probabilistic decision support tool is developed for selecting the optimal maintenance policy. The decision support tool primarily determines when and to what extent corrective maintenance should be performed. The corresponding overall maintenance costs are also calculated and secondary information regarding the activity duration is given. By means of the probabilistic approach, which captures the weather window uncertainty due to the environmental randomness, the results can be interpreted by the user based on the desired confidence level. In this research the weather window uncertainty is implemented by simulating a large number of random, but statistically identical environmental time series, which are based on available measurement data of the tidal field at EMEC, located at the Orkney Islands in the United Kingdom. The multivariate dependence between the significant wave height, wave peak period, wind velocity and current velocity is identified in the measurement set and fully represented in the generated time series by means of a pair-copula construction simulation. The necessity for having time independence cannot be met in the original dataset, which is why a new simulation approach is developed. This method consists of a sequential simulation of pair-copula constructions to include both the time dependence and multivariate dependence in the synthetic time series. Simulation of the set of synthetic time series showed to be more effective for describing uncertainty with respect to exclusively using the original dataset, due to the possibility of including more environmental realizations. The tidal array is represented as a semi-Markov decision process, which captures all costs and transition processes related to the deterioration and maintenance decisions. A policy optimization algorithm can then be used to find the optimal set of decisions and the corresponding maintenance cost rate which includes both the direct and indirect maintenance costs. The novel tidal system design of Damen Shipyards is then plugged into the decision support tool to determine the optimal maintenance policy and maintenance costs. The effect of different levels of detail for representing the tidal system have been compared and the benefits in terms of cost reductions of using this decision support tool with respect to less advanced approaches have been highlighted. Furthermore, multiple scenarios have been elaborated to identify the sensitivities in the cases of accounting for unreliability in the failure rates, varying the number of platforms in the array and including the economic fluctuations of the maintenance vessel day rates.


We describe a unifying framework for the systematic construction of integrable deformations of integrable σ-models within the Hamiltonian formalism. It applies equally to both the 'Yang–Baxter' type as well as 'gauged WZW' type deformations which were considered recently in the literature. As a byproduct, these two families of integrable deformations are shown to be Poisson–Lie T-dual of one another.


Long-term regular physical activity may prevent osteoporotic fractures,improve the bone density of spine and hip joint and increase muscle mass,muscle strength and force-generating capacity.And it will not cause osteoarthritis to those who have not suffered joint injuries before.As to the patients of osteoarthritis,physical activity of moderate intensity and low impact is helpful to improving symptoms and prognosis.Generally speaking,most of the researches prove that physical activity plays a positive role in keeping health of bone,joint and muscle.


Abstract : This report discusses the eigenvalues of the covariance matrix for an N-element LMS adaptive array. The effects of the signal and array parameters on these eigenvalues are discussed. A simple relation between the array output SINR and one of the eigenvalues is obtained for the case of strong interference and CW signals. (Author)


Palladium and platinum were reduced and precipitated in aqueous solutions by sodium tetrahydroborate, sodium phosphinate and ascorbic acid. Palladium was reduced by sodium tetrahydroborate, sodium phosphinate and ascorbic acid, and Pt by sodium tetrahydroborate. However Pt and Pd could not be individually separated by the active hydrogen which was generated during the reduction of Pd.


The 'economy of collaboration' refers to a method of organizing the production, distribution and consumption of goods and services based on cooperative relations. These are new ways to coordinate economic activities, in which openness to the outside, decentralization and peer-to-peer horizontal relationships play a more important role than in the past. The main reference is to activities linked to the digital economy, since they are the emerging forms of a definitely older phenomenon, but which is expanding on an ever-wider scale thanks to new technologies. These collaborative activities can be regulated differently, along a continuum that ranges from the pole of market exchanges to that of generalized reciprocity, with various intermediate mixed forms (hybrid markets; balanced reciprocity).


The carbocyclic nucleosides aristeromycin and neplanocin A are two of the most potent inhibitors of S-adenosylhomocysteine hydrolase, an enzyme that plays a critical role in methyl transfer reactions during a viral replication cycle. As a consequence, these two carbocyclic nucleosides have been found to have significant broad-spectrum antiviral activities. However, their clinical applications are limited due to the toxicity associated with their 5'-hydroxyl metabolites. To develop new antiviral agents that retain the antiviral activities of aristermycin and neplanocin A while avoiding their toxicities, homoaristeromycin (1) has been synthesized. Also, in order to detect the relationship between the syn-anti conformations of nucleoside analogues and antiviral activites, a series of 8-methyl carbocyclic nucleosides derivatives have been prepared. Among the analogues in this series 8-methylhomoaristeromycin (2) displayed a significant activity towards human cytomegalovirus (HCMV) and moderate activity against yellow fever virus. 3-Deazapurine carbocyclic nucleosides (that is 3-deazaaristeromycin and 3deazaneplanocin A) have been discovered to possess remarkable antiviral activites, especially towards Ebola virus, with limited toxicity. Therefore, in this dissertation research, the 3-deaza structural element was introduced to supplement the library of 8methylcarbocyclic nucleoside analogues that included 8-methyl-3-deaza-5′-


In this study, it was aimed to determine the effects of the addition of almond hull, which has no economic value and causes environmental pollution, to alfalfa silage as an easily soluble carbohydrate source on silage quality, fermentation characteristics and in vitro organic matter digestion (IVOMD). The groups were designed to contain 0% (control), 1%, 2%, 4% and 6% almond hull, respectively. When the IVOMD and metabolizable energy (ME) values of the silages were examined, increases were observed in all additive groups compared to the control group. When the pH, NH3-N/TN and carbon dioxide (CO2) values of the silages were examined, the highest values were determined in the control group, while the lowest pH, NH3-N/TN and CO2 values were determined in the silage group with 6% almond hull added. Although an increase was determined in all trial groups in terms of lactic acid (LA) and acetic acid (AA) values of silages compared to the control group, the highest values were determined in the group with 6% almond hull addition, and a decrease was determined due to the increase in almond hull in terms of butyric acid (BA) values. Yeast and mold values of the silages decreased due to the increase in almond hull compared to the control group. As a re- sult, it was determined that the addition of 6% almond hull as an easily soluble carbohydrate source had a positive effect on alfalfa silage quality and fermentation characteristics.


Ordos basin is one of the most potential petroleum reservoir region in China, Wangpanshan area is located at the middle-west in the Ordos Basin. It is one of key regions for recent petroleum exploration. Interval4 and 5 of Yanchang Formation and Interval6 of Yanchang Formation in the Triassic are the main objective exploration targets for elastic rocks in this area. The reservoir's characteristics including many genetic types, rock types, and reservoir interspaced types, as well as law porosity and permeability. The examination of the controls of the reservoir rocks indicates that the sedimentary micro-facies and diagenesis are the principal geological factor controlling the development and distribution of the reservoir rocks in the study area. This article mainly study physical properties of reservoir(porosity, permeability), the horizontal distribution of physical properties of reservoir and the vertical distribution of physical properties of reservoir.


The Legendre transform (LET) is a product of a general duality principle: any smooth curve is, on the one hand, a locus of pairs, which satisfy the given equation and, on the other hand, an envelope of a family of its tangent lines. An application of the LET to a strictly convex and smooth function leads to the Legendre identity (LEID). For strictly convex and three times differentiable function the LET leads to the Legendre invariant (LEINV). Although the LET has been known for more then 200 years both the LEID and the LEINV are critical in modern optimization theory and methods. The purpose of the paper (survey) is to show the role of the LEID and the LEINV play in both constrained and unconstrained optimization.


Aim. After all, the quality of medicinal raw materials, and subsequently the preparations made from them, directly depend on the number of weeds present in the crop. Currently, producers of agricultural products who cultivate medicinal plants, namely medicinal chamomile, are faced with such a question as the protection of medicinal crops from harmful organisms, especially weeds, during cultivation technology. The research was aimed at establishing the dependence of the growth dynamics of medicinal chamomile plants and the productivity of inflorescences on the degree of weediness of crops by segetal plants. Methods. The weed protection system included agrotechnical, chemical and integrated methods of control. Results. It was found that the most common weeds in the chamomile agrophytocenosis were Centaurea cyanus L., Polygonum patulum, Convolvulus arvensis L., Avena fatua, Echinochloa crus-galli L., Galinsoga parviflora Cav., Chenopodium album L., Galium aparine L., Raphanus raphanistrum L., Barbarea vulgaris R.Br. It was established that the use of the autumn sowing period of chamomile contributed to more effective suppression of weeds, since a certain number of weeds die in winter at low temperatures.The average weediness after harvesting the predecessor before preparing the field for sowing medicinal chamomile was 115–123 pcs./m2. Agrotechnical protection measures reduced the number of weeds to 42–50 pcs./m2, the use of herbicide, respectively – 17–18 pcs./m2, integrated protection – 12–15 pcs./m2. Conclusion. We have established that the Perlyna Lisostepu variety has significant resistance to weeds. As for the dependence of the growth dynamics and productivity of chamomile on the implementation of weed control measures, the combination of all measures, that is the use of only an integrated method, makes it possible to best deal with harmful plants namely to reduce their number on average over the years of research to 12 pcs./m2 and obtain a yield of 1.5 t/ha of raw mass of inflorescences.


An essential component of the school counselor's role is to provide support for all students to be college and career ready. This article provides an overview of the College/Career Success Skills (CCSS) program developed to help students successfully transition to postsecondary settings. The CCSS intervention teaches students' critical skills in the areas of content knowledge, transition knowledge and skills, learning skills and techniques, and cognitive strategies known to boost college and career success.


This work constitutes an introduction to the study of pottery production in ancient Issa. In a single place, it summarizes all previous data pertaining to pottery production confirmed by previous hypotheses thereon, while newly-discovered fragments of various pottery forms provide an insight into individual forms of Issa products during the Late Hellenistic and Early Roman periods. Pursuant to an analysis of the potsherds, pottery production in Issa can be followed from the third century BC, lasting until the third century AD at the very least. The fragments found testify to the diverse pottery production, from Hellenistic terracotta figures of Tanagra type and relief cups, to amphorae and dolia, juglets with single handles, stamped oil-lamps and so forth from the later Early Roman period. In cooperation with the Mining, Geology and Petrochemistry Faculty of the University of Zagreb, the first archaeometric analyses of ceramic fragments and possible deposits of clay on the island of Vis were conducted for the purpose of the best possible understanding of the actual process of making ceramics and the extent of pottery activity in this Eastern Adriatic city during the aforementioned periods. The results of these analyses are published here for the first time.


Pipeline leakage of Shandong LNG receiving station occurred on the eve of production,and how to solve this problem becomes the key factor of production before the first commercial LNG ship to the port. Shandong LNG receiving station proposed four solutions to pipeline leakage, and compared them from the aspects of security,quality and speed.Finally we chose to increase an inch flange short pipe to leakage part and use flange to seal after the completion of the welding. In this way, the repaired pipeline put into production on time and operates normally so far.


1273 Published By: Blue Eyes Intelligence Engineering & Sciences Publication Retrieval Number: E7347068519/19©BEIESP Abstract— Identifying Human Emotion is important in facilitating communication and interactions between individuals. They are also used as an important mean in studying behavioral Science and in studying Psychological changes. There are many applications which uses Facial Expression to evaluate human nature, their feelings, judgment, and opinion. Recognizing Human Facial Expression is not a simple task because of some circumstances due to illumination, facial occlusions, face color/shape etc. Since face is the prime source for recognizing human emotion, this paper will provide the best method that can be adopted for non-invasive real time emotion detection. This paper involves a comparative analysis of facial expression recognition techniques using the classic machine learning algorithmsKNN, SVM, Ensemble classifiers. The machine learning algorithms have been implemented on JAFFE IMAGE DATABASE on MATLAB 2016a. Successful and satisfactory results have been obtained giving the future researchers in this field an insight into which technique to be used when, to get the desired results.


A simple reaction of diethyl ( - )(S,S)-1,2-epoxy-2-phenylpentylphosphonate with 28% NH 3(aqu.) in MeOH led to the ethyl 1-formyl-1-phenylbutylphosphonate in excellent yield. The procedure consists simply in stirring the substrate and 28% NH 3(aqu.) in MeOH, at 40;C.


Cardiogenic shock is the commonest cause of death after acute myocardial infarction. It occurs in 7% of patients with ST segment elevation myocardial infarction and 3% with non-ST segment elevation myocardial infarction.

Cardiogenic shock is a progressive state of hypotension (systolic blood pressure < 90 mm Hg) lasting at least 30 minutes, despite adequate preload and heart rate, which leads to systemic hypoperfusion. It is usually caused by left ventricular systolic dysfunction. A patient requiring drug or mechanical support to maintain a systolic blood pressure over 90 mm Hg can also be considered as manifesting cardiogenic shock. As cardiac output and blood pressure fall, there is an increase in sympathetic tone, with subsequent cardiac and systemic effects—such as altered mental state, cold extremities, peripheral cyanosis, and urine output < 30 ml/hour.

### Cardiac effects

In an attempt to maintain cardiac output, the remaining non-ischaemic myocardium becomes hypercontractile, and its oxygen consumption increases. The effectiveness of this response depends on the extent of current and previous left ventricular damage, the severity of coexisting coronary artery disease, and the presence of other cardiac pathology such as valve disease.

A 65 year old man with a 3–4 hour history of acute anterior myocardial infarction had cardiogenic shock and acute pulmonary oedema, requiring mechanical ventilation and inotropic support. He underwent emergency angiography (top), which showed a totally occluded proximal left anterior descending artery (arrow). A soft tipped guidewire was passed across the occlusive thrombotic lesion, which was successfully stented (middle). Restoration of brisk antegrade flow down this artery (bottom) followed by insertion of an intra-aortic balloon pump markedly improved blood pressure and organ perfusion. The next day he was extubated and weaned off all inotropic drugs, and the intra-aortic balloon pump was removed

Three possible outcomes may occur:


White dwarfs carry information on the structure and evolution of the Galaxy, especially through their luminosity function and initial-to-final mass relation. Very cool white dwarfs provide insight into the early ages of each population. Examining the spectra of all stars with $3\sigma$ proper motion in the Sloan Digital Sky Survey Data Release 14, we report the classification for 20 088 spectroscopically confirmed white dwarfs, plus 415 hot subdwarfs, and 311 cataclysmic variables. We obtain Teff, log g and mass for hydrogen atmosphere white dwarf stars (DAs), warm helium atmosphere white dwarfs (DBs), hot subdwarfs (sdBs and sdOs), and estimate photometric Teff for white dwarf stars with continuum spectra (DCs). We find 15793 sdAs and 447 dCs between the white dwarf cooling sequence and the main sequence, especially below Teff= 10000 K; most are likely low-mass metal-poor main sequence stars, but some could be the result of interacting binary evolution.


Background and Objectives: Progressive muscle relaxation is a method designed to reduce stress and anxiety, and it can help to reduce perceived stress and cognitive avoidance. The purpose of this study was to investigate the effect of progressive muscle relaxation on perceived stress and cognitive avoidance among university students. Method and Materials: This semi-experimental study with pre-test and post-test design and control group was conducted with participation of 60 physical education students of Islamic Azad University in the second semester of the academic year 2016-2017. Participants were selected using simple random sampling method. Data were collected via perceived stress questionnaire and cognitive avoidance scale and analyzed via analysis of covariance by SPSS-22 software. Results: The mean (SD) age of the experimental group was 24.1 (3.8) and 24.5 (4.1) for the control group. The mean (SD) perceived stress score was 81.6 (2.8) in the experimental group, which decreased to 65.7 (3.1) in the post-test (P<0.001); however, the variation of the score was not significant for the control group. The mean (SD) cognitive avoidance score of the experimental group was 44.8 (4.2), which decreased to 32.4 (5.3) in the post-test (P<0.001) ); however, the variation of the score was not significant for the control group. Conclusion: The study showed that progressive muscle relaxation training could reduce the perceived stress and cognitive avoidance among physical education students. DOI:http://doi.org/10.22037/ch.v6i1.20834


The paper discusses norm setting of sanitary parameters and protection technologies of internal and external air quality of stationary and mobile objects of motor transport complex from heat input and harmful pollutants taking into account the specifics of their production and requirements forenergy efficiency.


MicroRNAs provide a new layer of regulation to ensure that a developmental program of programmed cell death yields a reproducible outcome in spite of perturbations to the system.


Objective. Emotion recognition based on electroencephalography (EEG) is garnering increasing attention among researchers due to its wide-ranging applications and the rise of portable devices. Deep learning-based models have demonstrated impressive progress in EEG-based emotion recognition, thanks to their exceptional feature extraction capabilities. However, the manual design of deep networks is time-consuming and labour-intensive. Moreover, the inherent variability of EEG signals necessitates extensive customization of models, exacerbating these challenges. Neural architecture search (NAS) methods can alleviate the need for excessive manual involvement by automatically discovering the optimal network structure for EEG-based emotion recognition. Approach. In this regard, we propose AutoEER (Automatic EEG-based Emotion Recognition), a framework that leverages tailored NAS to automatically discover the optimal network structure for EEG-based emotion recognition. We carefully design a customized search space specifically for EEG signals, incorporating operators that effectively capture both temporal and spatial properties of EEG. Additionally, we employ a novel parameterization strategy to derive the optimal network structure from the proposed search space. Main results. Extensive experimentation on emotion classification tasks using two benchmark datasets, DEAP and SEED, has demonstrated that AutoEER outperforms state-of-the-art manual deep and NAS models. Specifically, compared to the optimal model WangNAS on the accuracy (ACC) metric, AutoEER improves its average accuracy on all datasets by 0.93%. Similarly, compared to the optimal model LiNAS on the F1 Ssore (F1) metric, AutoEER improves its average F1 score on all datasets by 4.51%. Furthermore, the architectures generated by AutoEER exhibit superior transferability compared to alternative methods. Significance. AutoEER represents a novel approach to EEG analysis, utilizing a specialized search space to design models tailored to individual subjects. This approach significantly reduces the labour and time costs associated with manual model construction in EEG research, holding great promise for advancing the field and streamlining research practices.


The goal of this study is to present the mixed Tukey exponentially weighted moving average-modified exponentially weighted moving average control chart (MEME-TCC) for monitoring process location with symmetric and skewed distributions in an attempt to significantly improve detection ability. With the benefits of nonparametric assumption robustness. The average and median run lengths are supporting measurements for assessing the performance of a monitoring scheme using Monte Carlo simulation. Furthermore, the average extra quadratic loss (AEQL), relative mean index (RMI), and performance comparison index (PCI) can all be used to evaluate overall performance criteria. The proposed chart is compared with existing charts such as; EWMA, MEWMA, TCC, MEME, MMEE, and MMEE-TCC. The comparison result shows that the proposed chart is the best control chart for detecting small to moderate shifts among all distributional settings. Nevertheless, the EWMA chart detects large shifts more effectively than other charts, except in the case of the gamma distribution, where MEWMA performs best. The results of adapting the proposed control chart to two sets of real data corresponded to the research findings. Doi: 10.28991/ESJ-2023-07-03-014 Full Text: PDF


The problem is formulated of the energy levels deriving from the degenerate valence bands of a semiconductor in the presence of an impurity potential and a magnetic field. An approximate solution is found using perturbation theory, the variational principle and the adiabatic approximation.


In order to predict the mechanical noise of ship accurately.By combining the finite element method(FEM)and the boundary element method(BEM).Factors of vibration transmissibility and underwater radiation noise characteristics are researched.such as,different type of ship,different layout of power machinery and different disposal form of rib.On this basis,A new method is put forward to predict the radiation noise based on the empirical formula.And the underwater radiation noise of ship with different work condition were predicted.


The appearance of computer multimedia made our teaching face a new revolution.It promotes the improvement of teaching structures and teaching methods.Modern teaching is mainly composed of multimedia CAI,which uses computers as teaching tools and coursewares as teaching media.It plays an important role in improving teaching quality,promoting teaching and learning to enhance each other,modernizing teaching and learning,etc.This paper introduces how to use Powerpiont to develop material mechanics multimedia CAI courseware—the idea of development,principles of total design,structure of courseware,its function and work conditions.


Flash is a excellent tool of designing animation,which takes on a whole new object-oriented design model,has the faculty to create complex interactive applications.It was introduced of dynamic simulation for organization of train operation with Flash, the kernel, structure and methods of key technique,which were useful in scientific research and educational work.


• Objective: To review the evidence of the effectiveness of antioxidant vitamins for the prevention and treatment of cardiovascular disease (CVD). • Methods: Qualitative assessment of the literature. • Results: Data do not support the hypothesized cardioprotective effect of supplemental vitamin A, and there is a suggestion of toxicity with higher doses. Interventional studies with β-carotene fail to support any benefit on CVD and many suggest harm from β-carotene supplementation. Observational studies of vitamin C supplementation have yielded variable results. Small interventional studies with surrogate endpoints and large prospective interventions overall have not shown a benefit of vitamin E on preventing CVD. Meta-analyses of these large studies corroborate the lack of effect of vitamin E. A benefit of folate on CVD risk has been demonstrated, but recent fortification of grains in the United States with folate might limit the translation of these study results into current practice. Nicotinic acid decreases the risk of CVD through its effect on lipids, but side effects limit its use. The majority of vitamin combination studies suggest no benefit, and several notable vitamin combination studies raise the concern that some combinations may cause harm. Perhaps the strongest beneficial effect with multivitamins is seen in those with or at risk for baseline vitamin deficiencies. • Conclusion: Data from this review do not support the use of vitamins for primary or secondary prevention of CVD. Indeed, there is even the suggestion of possible harm in some groups. Thus, careful consideration is needed prior to prescribing or condoning supplemental vitamin use for the prevention or treatment of CVD.


The present invention provides a resin curing agent that is composed of a compound which contains one or more hydroxy groups and two or more thiol groups in each molecule, and which has a molecular weight of 100-2,000. The present invention also provides a one-pack type epoxy resin composition which contains: a component (1) that is a compound which contains one or more hydroxy groups and two or more thiol groups in each molecule, and which has a molecular weight of 100-2,000; a component (2) that is an epoxy resin which has an average of two or more epoxy groups per molecule; and a component (3) that is a latent curing accelerator.


The Liouville action F = ((25 - d)/48π) ∫ (½(∇ϕ)2 + λ exp[ϕ])d2x, with proper-time cut-off ε, is considered. This action describes the behaviour of the conformal factor ϕ(x) in Polyakov's model of bosonic strings and random surfaces. For λ = 0, it is argued that the resulting partition function is not defined for any d > 1, even when ε is finite. The proposed instability of the theory is associated with a proliferation of singular "spikes" of the form ϕ = -2 log(x). This finding appears consistent with the view that the random surface is asymptotically a branched polymer in space dimensions d > 1.


ABSTRACT Photoreactive polymers with optical anisotropy, which may be applied as the photoalignment layer for liquid crystal display, were synthesized through two-step reaction between several kinds of epoxies and cinnamate groups. The photoreactive polymer film was formed by spin-coating and then exposed to linearly polarized UV light with the wavelength of 254 or 365 nm. The optical anisotropy of the polymer film caused by the selective cycloaddition of the cinnamate groups was confirmed from the polarized UV-vis spectra. The polymer films irradiated by the polarized UV light showed anisotropic absorbance in the polarized UV-vis spectra, while the polymer irradiated by unpolarized UV exhibited isotropic absorbance. We also confirmed the photoreactive polymer film could align liquid crystal. LC cell fabricated using the polymer films irradiated by linearly polarized UV showed anisotropic transmission of the polarized visible light, while the cell fabricated using the polymer films irradiated by unpolarized UV exhibited isotropic transmission.


The sonochemical preparation of PbTiO3 fine powders with lead acetate trihydrate and tetrabutyl titanate as precursors is reported in this paper. Narrow size distribution (40–60 nm) of gel-derived PbTiO3 nanocrystallites at 520°C was revealed by transmission electron microscopy. The preparation processings with ultrasonic irradiation and a control test without ultrasonic irradiation for comparison were investigated. Results of phase evolution, microstructure, and thermal analysis of gels were characterized and discussed between the control test and the ultrasonic preparations. Acoustic cavitation exerted an important influence on nucleation, gelation, and homogenization of as-prepared gel, which contributed to the evolution of the resulting gel on further heat treatment. The sonochemical gel was detected to crystallize at temperature, as low as about 410°C, which was confirmed by X-ray powder diffraction and thermogravimetric analysis and differential thermal analysis (TGA–DTA).


Abstract The article presents an auto-tuning method of state feedback voltage controller for DC-DC power converter. The penalty matrices employed for calculation of controller's coefficients were obtained by using nature-inspired artificial bee colony (ABC) optimization algorithm. This overcomes the main drawback of state feedback control related to time-consuming trial-and-error tuning procedure. The optimization algorithm takes into account constraints of selected state and control variables of DC-DC power converter. In order to meet all control objectives (i.e., fast voltage response and chattering-free control signal) an appropriate performance index is proposed. Proper selection of state feedback controller (SFC) coefficients is proven by simulation and experimental tests of DC-DC power converter.


Cloud computing is introducing many huge changes to people's lifestyle and working pattern recently for its multitudinous benefits. However, the security of cloud computing is always the focus of numerous potential cloud customers, and a big barrier for its widespread applications. Cloud federations allow Cloud Service Providers (CSPs) to deliver more efficient service performance by interconnecting their Cloud environments and sharing their resources. However, the security of the federated Cloud service could be compromised if the resources are shared with relatively insecure and unreliable CSPs. A federation formation algorithm that enables CSPs to cooperate while considering the security risk introduced to their infrastructures, and refrain from cooperating with undesirable CSPs. According to the stability-based solution concepts that use to evaluate the game, the model shows that CSPs will be able to form acceptable federations on the fly to service incoming resource provisioning requests whenever requires.


Relationship between intermolecular hydrogen bonding and features in the low-wave-number infrared (IR) and Raman spectra of liquid formamide (FA), N-methylformamide (NMF), and N-methylacetamide (NMA) is studied by performing ab initio molecular orbital calculations on clusters of these molecules. Strongly Raman-active modes are calculated at ∼200 and ∼100 cm−1 for the FA hexamer consisting of two antiparallel linear trimers, but only at ∼100 cm−1 for the NMF linear tetramer and the NMA linear trimer. These calculated results are consistent with spectral features observed in the liquid state. The IR spectra calculated for these cluster species are also in agreement with experimental results. By contrast, no strongly Raman-active mode is calculated for the FA linear hexamer in the 250–150 cm−1 region. The strong Raman band of liquid FA observed at ∼200 cm−1 is therefore characteristic of two-dimensional hydrogen bonding. The origin of the spectral features is examined by calculating the IR and Raman intensities arising from translations, rotations, and methyl torsion(s) of each molecule. It is clarified that the Raman intensities in the low-wave-number region mainly originate from rotational motions in the out-of-plane direction and is explained by anisotropy of the polarizability tensor of each molecule. The IR intensities in the low-wave-number region mainly arise from rotations of the permanent dipole moment of each molecule, but other factors also have some contributions. © 1998 John Wiley & Sons, Inc. Int J Quant Chem 70: 241–252, 1998


One of BJSN's Teaching Tips columnists, Krista Faber, decided to dedicate this month's page to lesson plans in the hope of providing readers with some time-saving resources at this busy time of the year.


Purpose
The purpose of this paper is to present the findings from an evaluation of an intervention (Moving Parents and Children Together (M-PACT+)) aiming to address the effects of parental substance misuse (PSM) in school settings. The paper considers the evidence of effectiveness, and goes on to explore how schools were involved with the intervention.

Design/methodology/approach
A theory of change was developed for the intervention, which identified key steps of change that were expected for the beneficiaries (family members and children). Mixed methods were then used to form a portfolio of data to support or refute the theory. The data included quantitative validated scale data and questionnaires at various points in time with staff, and participants (including children), and qualitative data obtained from school staff, intervention staff, families and children.

Findings
This paper concludes that the evidence supports the theory that providing M-PACT+ in school settings can begin to address the effects of PSM for the families that engage with it. Further, the paper shows that the ethos of the schools involved influences how families are identified and referred, and that interventions of this kind are most likely to succeed where they are integrated into an ethos where there is a shared responsibility for a broad child well-being agenda between schools and other community agencies.

Originality/value
This paper explores the evaluation of a unique family intervention. The findings will be of value to those seeking to implement such interventions in partnership with schools and/or community agencies.


In any negotiation, one of the most important parts of the negotiator's task is deciding whether or not to accept the opponent's offer. Actually, the most challenging thing is answering this question: which offer and when must be accepted? A wide range of simple to sophisticated acceptance strategies have been proposed: simple acceptance strategies which have the constant threshold value and sophisticated strategies that notice both utility and time in order to determine acceptance thresholds. This study introduces a novel statistical acceptance strategy with considering the similarity between the opponent's offer and our previous offers, which is combined with existing usual acceptance strategies. Experiments show our strategy has advantages against the state-of-the-art acceptance strategies.


A load balancing approach is undertaken to methodically characterize the average overall conclusion time in a distributed system to improve the quality of services. This comes close toconsider the delays imposed by the communication medium. The load balancing approach is developed to improve the certain parameters of quality of services that dynamically reallocate the incoming external loads at each server. One of the most important issues in distributed systems is to design of aproficient dynamic load balancing algorithm that improves the taken as a whole performance of the distributed systems. Scheduling and resource management plays animportant role in achieving high utilization of the resource in grid computing environments. Load balancing is the procedure of distributed the load betweendiverse nodes of a distributed method to find improved both job response time withreservedeployment while also avoiding a situation where altered of the nodes are deeply loaded while other nodes are idle or lightly loaded. The performance the load balancing approach is shown in a simulated way using progress bars that shows how progress bar at each server performs before using load balancing approach and after using load balancing approach.


This article examines the use of empowerment as a central component of counseling and as a criterion for evaluating counseling interventions. Definitions of empowerment across several perspectives are discussed and a definition of empowerment in the context of counseling is proposed. Based on this definition, potentially empowering and disempowering aspects of counseling are presented. Measurement and research issues and recommendations related to empowerment are highlighted.


Caftaric acid is simply known as phenolic derivative and it is present in high concentrations in grape seeds an d juice. The chemical structure of caftaric acid is C13H12O9, with molar mass of the acid equal to 312.230 g/mol. Caftaric acid is formed united of caffeic acid and tartaric acid. This paper reviews caftaric acid structure, daily consumption, bioavailability and pharmacological effects. The caftaric acid quickly passes to the stomach and duodenum and increases the absorption of the acid in the intestinal Caco -2 cells. The antioxidant effect of grape stem was related to its caftaric acid constituent. The grape juice has anti-inflammatory effect and this anti-inflammatory effect is correlated with the main constituent of this juice which is caftaric acid. Caftaric acid has antimutagenic effect in an animal model suggesting that caftaric acid participates in chemopreventive effect of the Yamabudo juice. The "liver detoxifying" effect is observed and correlated with oral supplementation with aqueous decoctions of Cichorium spinosum and Cichorium intybus in Greece where caftaric acid is the major constituent of these two aqueous decoctions. The caftaric acid possesses a double effect through decreasing high blood glucose and high blood pressure so this acid can be used in the treatment of diabetes and hypertension. The caftaric acid increases granulocyte/macrophage-colony forming cells from femurs of female animals' models by 70%. In conclusion, caftaric acid is presented about 5 mg/100 cm 3 grape juice. The acid is quickly passes into the stomach and duodenum. The trans-caftaric acid represents 85% of the total phenolic content in the Concord grape juice with a total concentration of 444 μmol/L. The caftaric acid has many pharmacological effects such as antioxidant, anti-inflammatory, antimutagenic and anticarcinogenic, hepatoprotective, antidiabetic and anti-hypertensive, anti-obesity and anti-metabolic syndrome and neuroprotective effects.


chapter on this material covers iteration using simple looping structures, and the next gives an introduction to recursion. The next 3 chapters then refine the knowledge gained in these two constructs. I wholeheartedly concur with their views in this matter. This is a good book, which is carefully tailored to the effective learning of programming in LISP. If one wants to learn LISP, then this book should certainly be incorporated in a short list before making a final decision.


Time-evolution patterns for energy absorption in a driven H\'enon-Heiles Hamiltonian with and without extra off-diagonal random-coupling terms are reported. The time dependence of the average number of photons absorbed is quite different for these two systems, being fluence dependent for the latter. Similarities are found between the dynamics of the driven system with random coupling and a four-mode molecular model which interacts with a quantum monochromatic field. Comparison is made between the presently found mechanism of excitation and the diffusive energy growth due to externally induced chaos found in the kicked-rotor or in microwave ionization of the hydrogen atom.


Background Biodegradable stent coatings provide a potential for local drug delivery at the time of vascular injury, while possible tissue toxicity is avoided through constant degradation, leaving behind a bare metal stent. Design Serial three‐dimensional (3D) intravascular ultrasonographic results on bare Megaflex stents and biodegradable polymer‐coated Megaflex stents (Hyper stents) (Eurocor, Bonn, Germany) were compared 1 and 4 weeks after intracoronary implantation in pigs. Methods Under general anaesthesia, the left anterior descending and circumflex coronary arteries of domestic pigs were stented with Megaflex and Hyper stents, using right femoral artery access. Control coronary angiography and intravascular ultrasonography (IVUS) were performed 1 and 4 weeks after stent implantation using left femoral artery access and right carotid artery access. After recording of angiographic and IVUS data, the pigs were allowed to recover. Results The 1‐ and 4‐week IVUS follow‐ups revealed less neointima formation with Hyper stents than with Megaflex stents: 1‐week intimal volume, 11.8± 0.93 compared with 15.02 ± 4.18mm3, P = 0.065; intimal area, 0.81 ± 0.06 compared with 1.1 ± 0.16mm2, P = 0.003; maximal intimal thickness, 0.12 ± 0.01 compared with 0.14± 0.02 mm, P =0.049; 4‐week intimal volume, 12.4 ± 1.77 compared with 27.32 ±12.79mm3, P =0.016; intimal area, 0.82 ±0.12 compared with 1.95 ±0.65mm2, P = 0.003; and maximal intimal thickness, 0.13 ± 0.04 compared with 0.30± 0.10 mm, P = 0.003. Conclusions Implantation of biodegradable polymercoated (Hyper) stents results in significantly less neointima formation 1 and 4 weeks after intracoronary implantation than with bare Megaflex stents. Taking advantage of the good collateralization of femoral and carotid arteries of pigs, the use of different arterial accesses allows serial angiographic and 3D IVUS measurements on neointimal development without sacrificing the animals. Coron Artery Dis 14:409‐412 •


Most of student doesn't like to study mathematic. This course is still assumed as the difficult lesson to be learned by student from elementary, junior high school, senior high school even varsity. Thus, for the student who belief incapable doing the math task, they are loath to learn mathematic. It is proven from the interview result with respondent and people outside. It is possible bring this lesson on student to receive low score. This research aims to examine the relationship between school environment and math performance on student grade VIII in SMPN 10 Batam 2017. This research is using analytic study design by employing cross-sectional approach. The population involved the student of SMPN 10 Batam with 83 respondents. The result shows that there is no correlation between school environment and math performance on student grade VIII in SMPN 10 Batam 2017. The data analyzing technique is chi square test with p - value = 0,185 > 0,05. In suggestion, for the educational institution which is the place for teaching and learning process, it is expected to provide both infrastructures and environmental of school well to support safe and confinement learning process for the student.


The aim of this article is to analyze the relationship between poetry and painting in the Abstract Expressionism. For that three names: Clement Greenberg (art critic), Frank O'Hara (a poet) and Willem De Kooning (painter). Through these names try to point out the close relationship between poets and painters in the so-called New York School.


Coal bed has more complex pore structure compared with conventional natural gas reservoirs.A method of calculating pore fractal dimension is derived by using capillary pressure curves and derivative methods;and separate calculation is discussed.Based on the fractal dimension calculated by capillary pressure curves with coal sample of Qinshui Basin,the influence factors of fractal dimension is analyzed and it is found that different coal samples have different pore structures and fractal dimension is obviously different.


Abstract Seven commercially available: Zorbax C18, Kromasil C18, C8, cyano, phenyl, monolithic, and amino stationary phase columns, have been characterized and classified into broadly similar types to simplify column choice. The results were evaluated employing cluster analysis, which shows several interesting groups based on distances (Minkowski and Euclidean) in agreement with the manufacturer's claims: chain density of the stationary phase used, and the presence or not of a silica base. Finally, results showed that C18 columns offer the best chromatographic characteristics for separation and quantification of antibiotics in micellar liquid chromatography.


Creatine is alleged to be an ergogenic aid to enhance sports performance and recently became a popular sports nutrition supplement. Although short-term supplementation of creatine has not been associated with major health risks, the safety of prolonged use has caused some concern. The present study demonstrates that creatine is metabolized to methylamine, which is further converted to formaldehyde by semicarbazide-sensitive amine oxidase (SSAO). Formaldehyde is well known to cross-link proteins and DNAs, and known to be a major environmental risk factor. SSAO-mediated production of toxic aldehydes has been recently proposed to be related to pathological conditions such as vascular damage, diabetic complications, nephropathy, etc. Chronic administration of a large quantity of creatine can increase the production of formaldehyde, which may potentially cause serious unwanted side-effects.


How refreshing. An exhibition about the simple things in life... and er, death. Life. Death. Thereafter is one of those epic shows that comes around once in a blue moon. During his guest contract at Silvershot Gallery, Melbourne-based curator Mark Feary produced a relatively new exhibition model, which consists of three separate, distinct, but thematically entwined shows, running end to end for eighteen days each. It's a welcome and successful alternative to the static, traditional; 'open for ages - closed and forgotten' model.


Abstract And a theory that covers holiday, day of the week and seasonal effects simultaneously. According to "broken promises" theory the frustration created by a gap between raised expectations and stubborn reality brought about by such factors as weekends and holidays should increase suicide risk. The present study tests the broken promises theory on race-specific indicators of suicide (n = 188,047) and extends it to homicide (n = 167,790) as well. The results of a time series analysis indicate support for four out of six hypotheses for nonwhites and six out of six hypotheses for whites. Given a tendency of nonwhites towards the externalization of aggression, the disappointments associated with temporally related broken promises are more apt to trigger homicide than suicide.


Movement lies at the heart of matter; all matter is always moving, in many different modes. Matter organised in the form of living cells and animals does something peculiar, however. Its collective movements are purposeful and goal-oriented, geared for the appropriation of an immediate future and generally for the preservation of its existence. The organisation of the movement of matter lies at the heart of living: from the organised biochemical activity within small compartments of cells, to the movements and activities of cells and cell systems, to the gross body movements of large multicellular organisms like you and I. All of life is the organised movement of matter. Living organisation enacts purposeful behaviours that sustain the existence of the living thing, a feature that I will show here fundamentally requires prospective control to anticipate the future present. How an organism senses and moves prospectively purposefully within its environment is an essential question for the emerging "systems" sciences, and is the theme for this paper.


Composted livestock waste (CLW) was studied as one low-cost material to remove Pb(II), Cu(II), Cd(II) and Zn(II) from simulated acid mine drainage (AMD) by batch and column experiments. The adsorption isotherm data were well fitted by the Langmuir model. The maximum monolayer adsorption capacities were 0.5485 mmol/g for Pb(II), 0.4092 mmol/g for Cu(II), 0.2246 mmol/g for Cd(II), and 0.1879 mmol/g for Zn(II) at pH 4.0. Due to the competition effect, the adsorption capacity of the single metal ion decreased in the multiple metals system compared with single metal system. The removal equilibrium for Pb(II), Cu(II), Cd(II) and Zn(II) occurred at pH of 3.0-3.5, 4.0-4.5, 4.5-5.0 and 6.0-6.5, respectively. There was relatively high adsorption efficiency even in acid conditions (pH 2-4), especially for Pb(II). Breakthrough curves demonstrated the effectiveness of adsorption in column experiment for treatment of heavy metals in AMD. This study confirmed that CLW could be efficient for heavy metal ions removal from acid mine drainage or acidic coal refuse leachate.


Aged persons represent a particularly vulnerable population segment. Given the rapid increase in their number and the proportion, aged care is increasingly gaining importance. At present, very little information is available on the extent and profile of needs and services that are required dor the elderly citizens of Belgrade. This work provides its contribution in trying to measure such needs on the representative sample of N=547 oldest old from 10 municipalities of Belgrade City. Results of this work come from a cross sectional study, carried out in the second half of 2004. The questionnaire based interview was administered at participants' homes. It covered following health and social domains: (1) general socio-demographic information (2) social activity and social integration (3) nutrition and health risks, (4) health state, based on self reported morbidity and presence of 24 signs and symptoms (5) functional status assessment based on their ability to perform vargoious activities of saily living and instrumental activities of daily living (6) utilization and availability of various health services (7) assessment of needs for various specialized aged care services and (8) SF-36. These results provide framework and the basic for future work of health planners as well as all interested parties in the area of aged care. While a missing local comparison context renders interpretation of current results quite difficult, one general conclusion that can be drawn from them is that current extent of needs significantly exceeds available resources and capacities. Integrative solutions and systematic planning are therefore needed in the future development of aged care in Serbia.


Objective To observe the expression of human β-defensin-1(hBD-1) and human β-defensin-2(hBD-2) in recurrent nasal polyps,and to investigate the role of β-defensin in the recurrent nasal polyps.MethodsTissues of nasal polyps was obtained from 10 patients with nasal polyps undergoing endoscopic sinus surgery,recurrent nasal polyps from 10 patients 6 months after surgery,nasal mucosa from 10 recovered patients with nasal polyps postoperatively and,10 control subjects.hBD-1 mRNA and hBD-2 mRNA levels of tissue specimens in all groups were detected by reverse transcripatase-polymerase chain reaction(RT-PCR).ResultsThere was no significant difference in hBD-1 mRNA level between the 4 groups(P0.05).Expression of hBD-2 mRNA was detected in patients with nasal polyps and recurrent nasal polyps,but rare in the recovered patients and the control subjects.ConclusionhBD-1 is a constitutive expression and hBD-2 is an induced expression.β-Defensin may play an important role in forming the nasal polyps.


. River biodiversity is threatened globally by hydropower dams, and there is a need to under-stand how dam management favors certain species while fi ltering out others. We examined aquatic invertebrate communities within the tailwaters 0 – 24 km downstream of seven large hydropower dams in the Colorado River Basin of the western United States. We quanti fi ed aquatic invertebrate dominance, richness, abundance, and biomass at multiple locations within individual tailwaters and across the basin and identi fi ed biological community responses associated with dam operations and distance from dam. We found that each tailwater was dominated by 3 – 7 invertebrate taxa, accounting for 95% of total abundance. Half of these dominant taxa were non-insect, non- fl ying species and thus were unavailable to terrestrial consumers. Consistent with previous studies, aquatic insects and sensitive taxa were negatively associated with hydropeaking intensity (magnitude of daily fl ow fl uctuations associated with hydropower genera-tion), which limits the composition and potentially the quality of the invertebrate food base. While total invertebrate abundance and biomass did not change with increasing distance downstream from dams, insect and sensitive taxa richness, abundance, and biomass all increased, suggesting that impacts of hydropeaking are most acute immediately downstream of dams. Our results demonstrate that tailwaters experiencing hydropeaking support high abundances of aquatic invertebrate, but the diversity of these communities is low.


Epilepsy is a periodic disease par excellence, for its iterative property is more important than its phenomenological stereotype. Only the epileptic's cortex evokes the fragments of past experience, time and time again, when electrically stimulated. Epileptic periodicity is regular only in one out of ten, if sequence of occurrence is measured according to the calendar. TABLE 1 shows that only 9.8 per cent of an epileptic population of 1,105 followed regular periods (counting three or more attacks in a row). Of these, 75 per cent were women, 25 per cent were males. In the women, attacks occurred about every 28 days (give or take one to four days) in 80 per cent, 10 per cent every two weeks, the rest a t intervals of two, three, and six months. Of the men, 50 per cent a t 28 days, five per cent a t two weeks, 15 per cent a t two months, 7 per cent a t three months, 11 per cent a t four months and 12 per cent a t six months. Periodicity is regular in one out of two if frequency is analyzed according to the clock. TABLE 2 shows that 28 per cent of the same epileptic population had nocturnal seizures (male/female ratio = 6/4). Sixty-nine per cent had attacks in the first two hours of sleep (80 per cent psychomotor, 20 per cent grand mal) , 24 per cent in the last two hours (71 per cent grand mall 29 per cent psychomotor) and in between 7 per cent (91 per cent psychomotor, 9 per cent grand mal). Of the total population there was an additional 22 per cent who had attacks just before and jus t after sleep (one hour) with all forms of seizures evenly represented. The heavy clustering of attacks around certain days of the calendar aside from menstruation has intrigued scientists and magicians from time immemorial. Klimmer,' by studying institutionalized epileptics, tried in vain to t ie the 28-day cycle to periods of full moon, a theory held by no less a neurological authority than Romberg. Dretler* counted 28,000 attacks (including 250 status epilepticus) for five years and found no correlation with atmospheric changes. Buscaino3 reviewed the world literature and found that the majority of authors assigned ictophil properties to the following factors : winter months, rain and snow, low barometric pressure, strong barometric variations, cold and humid air, the first hours after onset of sleep, and the early morning hours of 3-5 A.M. These were believed to facilitate, rather than prepare, predispose for, or precipitate seizures. The theoretical modus operandi was to the effect that an increase


THE INVENTION IS ON NEW AMINOALCANOYLDIBENZOD, FORMULA G1,3,6DIOXAZOCINES: (CF DRAWING IN BOPI) SUCH COMPOUNDS OF PROPERTIES ARE LOCAL ANESTHETICS, tranquilizing and SEDATIVE AND antiparkinsonian.


Searching for information is often driven by some work tasks that involve information use and require certain types of outcomes other than finding information. To explore how search systems can help with work tasks calls for examining factors that influence work task performance. A 3-stage controlled lab experiment was conducted with 24 participants, each coming 3 times to work on 3 sub-tasks of a general task, couched either as "parallel" or "dependent" task type. The full task was to write a report on the general topic, with interim documents produced for each sub-task. Results show that task type and task session did not affect users' task performance, but users' topic familiarity and task experience did. Users' effectiveness in finding useful pages and their time allocated to writing correlated with task performance, so did their reflected perceptions of task experience. Further, users' topic familiarity could lead to a higher writing efficiency, and task experience could lead to higher searching efficiency and effectiveness. These findings help understand factors affecting information use task performance, and have implications on search system design to support information related work task accomplishment.


Riemannian metrics on Shape spaces of curves and surfaces Alice Barbara Tumpach Laboratoire Painleve, Lille University, France GSI 2017 Alice Barbara Tumpach Riemannian metrics on Shape spaces of curves and surfaces Outline Part I 1 What are the Model spaces of infinite-dimensional geometry? 2 What are the Tools from Functional Analysis? 3 What are the Toys we can play with? 4 What are the Traps of infinite-dimensional geometry? Part II A trap of infinite-dimensional geometry : there exist Poisson brackets that are not given by bivector fields Part III 1 Shape spaces as Quotient versus Sections of fiber bundles 2 Riemannian metrics on Shape spaces 3 Gauge invariant metrics on Shape spaces Alice Barbara Tumpach Riemannian metrics on Shape spaces of curves and surfaces Model spaces Tools Toys Traps What are the Model spaces of infinite-dimensional geometry? Hilbert ⊂ Banach ⊂ Frechet ⊂ Locally Convex spaces Hilbert space H = complete vector space for the distance given by an inner product = h·, ·i : H × H → R+ symmetric :hx, yi = hy, xi bilinear : hx, y + λzi = hx, yi + λhx, zi non-negative : hx, xi ≥ 0 definite : hx, xi = 0 ⇒ x = 0 H∗ = H (Riesz Theorem). Alice


There are many ways to organize forensic science laboratory in the different country. The inner organization and parent organization of forensic laboratory, and forensic service system have been reviewed and discussed in this paper. The conclusion was that there is no single answer to the optimum organization of forensic science laboratory.


The State Electricity Commission of Victoria transports and stores some 35 million tonnes of brown coal per year. This material has highly variable properties, including a high moisture content and high adhesion, thus making it a difficult material to handle compared with other typical bulk solids. In the recently commenced Loy Yang Open Cut, near Traralgon in Victoria, a layer 5 to 10m thick of weathered coal has been encountered at the surface of the coal seam. This material is a high calorific value useable coal but has adhesive properties that produce adverse flow conditions. Flow properties of normal (unweathered) coal, weathered coal and briquette grus (fine particles) are presented in this paper and discussed. The difficulties encountered during the testing of these materials and means used to overcome these difficulties are also presented.