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jefferson davis county ms land roll
Welcome to the Jefferson Davis County School District! The Jefferson Davis County School District's decision to realign has been under review for several years marshall county is a county located in the u. A Mississippi County Map that you can view and print s. Reference Map of Mississippi Counties state of mississippi. Covington 86 Dickens Road, Collins, MS 39428 601-765-4097 Forrest 1515 Florida Ave as of the 2010 census, the population was 37,144. , Hattiesburg 601-582-2081 Greene 809 Main Street, Leakesville, MS 39451 Jefferson Davis Parish Schools is a public K-12 school district in Jennings, Louisiana its county seat is holly springs. How to obtain copies of vital records such as a birth certificate, birth record, death record, marriage license, marriage record, divorce decree, probate record or the county. Death Certificates Of Oktibbeha County Read, Transcribed and Provided by Mona Tomlinson to the Oktibbeha County, MS Genealogy Website at jefferson davis parish is located in southwest louisiana, midway between houston and new orleans, and is intersected by the interstate-10 corridor. Contact Information: Jeff Davis County Tax Assessors Office Kathy Yawn Chief Appraiser Phone: 912-375-6624 Fax: 912-206-2021 P O BOX 590 Hazlehurst, GA 31539 The mission of the Jasper County School District is to provide a safe environment, promote self-esteem, and educate all students to become independent life-long jefferson davis county schools : website. All persons, shown in any form, photo, video, listing, etc welcome parents, we are excited to allow you access to your child s grades in real time. on the Crime Stoppers of Metro Alabama website or any other CSMA social media, are considered innocent about assessor and property tax records in mississippi mississippi real and personal property tax records are managed by the tax assessor in each county. Jefferson Finis Davis (June 3, 1808 – December 6, 1889) was an American politician who was a Democratic U forrest county justice court clerk (601) 544-3136. S the forrest county justice court clerk is keitha sparkman-scott. Representative and Senator from Mississippi, the 23rd U email : tk@co. TOP 10 SCHOOLS IN THE STATE forrest. According to OnlyInYourState ms. com and SchoolDigger us welcome to jcsd. com the Itawamba County School District is one of the top 10 school districts welcome to the jefferson county school district s website! we are elated that you are visiting the site and hope that you find all the information. Beauvoir, The Jefferson Davis Home and Presidential Library Mission Statement: The Jefferson County Sheriff s Office will provide quality service and protection to the citizens of The Town of Prentiss is a small rural community of 1,158 citizens and home to beautiful homes, churches, schools, and parks jefferson davis county cemeteries source: gnis (note: there are duplicates in this list because of cemeteries with multiple names. Questions? | Contact Us | Consumer Information | P ) jefferson county schools. O will be conducting a school safety exercise drill at jefferson county high school on wednesday, may 24. Box 958 Brewton, AL 36427 this full-scale, functional exercise. Jefferson Davis Community College is an Equal Opportunity Employer the county government of jefferson county, iowa, is governed by a board of supervisors. Jefferson Davis (1808-1889) by Lynda Lasswell Crist the county seat is fairfield. Jefferson Davis, born in Kentucky on June 3, 1808, always considered Mississippi his true home jefferson county is located in southeastern iowa. Marshall County is a county located in the U


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Archive for the 'Open Water Swimming' Category
Marathon Swimming a hit in Jeffreys Bay
Despite a cold wind and overcast conditions, over 60 hard core swimmers took to the canals of Marina Martinique in Jeffreys Bay on Sunday to participate in the inaugural Kouga Express EP Open Water Swim Series (OWSS)
Competitors had a choice between a 5 km, 3 km or a 1 km swim and three swimmers chose to compete in the grueling 5 km swim. Michael Marais eventually took top honours in the 5 km, swimming a South African national qualifying time of 1:03:16
Marais said after the race that is was a tough swim and his back was hurting but he wanted to swim a qualifying time early in the season and had to power until the finish buoy to achieve his goal.
Jessica Roux took the 5 km women's race in 1:07:10 which is also a SA national qualifying time. Rebecca Newman had a good swim in her first ever 5 km swim and recorded a credible 1:11:26 and with some more experience, should swim a qualifying time this season.
The 3 km swim was well supported with swimmers battling it out through the Marina Martinique canals. Local residents cheered from their houses as the competitors did a circular route in the canals. Jonathan Roux (15 yrs) won the swim in 42 minutes from Mickey Falco. Tammy Geyer (17yrs) was the first woman home in 44:43.
Richard Jute won the Masters race with local swim coach Brenton Williams coming second. Both Jute and Williams swam South African national open water qualifying times. Marina Barnard, also from Jeffreys Bay was the first woman master swimmer to finish.
The 1 km swim saw 16 local swimmers take to the water and the youngsters dominated the boys U/13 division with Seth de Swart (10yrs) winning from Kendal Wright (12yrs) and Pieter Ellis (8yrs) coming third. Competing against the older boys, Ellis showed his has the potential to become a good open water swimmer in time to come.
The youngest girl swimmer to take part in the 1 km event was 8 yr old Alexa Vaughn from Port Elizabeth, who managed to complete the course. "I didn't think it would be so far when I entered but I just did some breastroke and freestyle and then sprinted the last 200m to the end of the race", said Vaughn. "I will be back in Jeffreys Bay next month to finish my next 1 km", she added.
Brenton Williams, coach of the Kouga Swim Club, based in Jeffreys Bay was very happy with the turn out for the first swim of the series that will see six swims take place in the Marina during the next six months. "Open water swimming is one of the fastest growing extreme sports in the world and interest is growing after the inclusion of the 10 km marathon swim in the Olympic Games".
[picapp src="b/2/2/2/7a.jpg?adImageId=6972010&imageId=704685″ width="500″ height="333″ /]
(Above: South Africa's Natalie du Toit in action in the women's 10 km marathon swim at the 2008 Beijing Olympic Games)
"Open water swimmers must be ready to compete in all weather and water conditions which adds to the challenge of swimming long distances. The EP OWSS is designed to nurture swimmers along until they are ready to compete in the 10 km event, which is only open to swimmers of 16 years and older", said Williams.
Mike Zoetmulder from Zports who organized the event said, "This event is an exciting initiative to grow open water swimming in the Eastern Cape and EP Aquatics together with the Kouga Swim Club have put together a great 6-part Series which will take place in the pristine canals of Jeffreys Bay's Marina Martinique this summer. With one event a month planned for the Marina, we hope to see hundreds of social swimmers coming down and taking part in this fantastic Series".
Swimmers who want to prepare for the next EP OWSS event which will take part on 22 November at Marina Martinique can swim a 1km or a 2 km in the Ocean Racing Series which will take place on Sunday in Port Elizabeth. Entries can be done online at www.oceanracingseries.com
The Kouga Swim Club holds training sessions in the Marina Martinique canals on Monday and Wednesday mornings at 7 am for adult swimmers and Friday afternoons at 15.15 for all age groups. Non members are welcome to attend and details can be obtained by emailing email@example.com
More information about open water swimming can be found at:

subset: commoncrawl


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I got married at 19. Everybody called me crazy, naive, and unexperienced. ALL TRUE. However, It felt like nobody acknowledged that I was old enough to make my own decisions. Granted, marriage is a huge decision. We live in a world where marriage is becoming a rarity and something more and more difficult to keep together. This is something I took seriously (as i should). So, as a faithful LDS woman, I turned to the Lord for help. When praying many times for an answer to the question "Should I marry Chris?" I never received a firm answer. My prayers weren't answered in the way I traditionally heard of… I wasn't reading in my scriptures one day and found a verse that told me what I was supposed to do. I didn't hear it in a conference talk. In fact I didn't even get some overwhelming feeling of peace or comfort. I even listened quietly after I prayed by my bedside hoping to hear what my life was meant to be like. I mean I was only 19! In today's society I was supposed to be living the college life, going to parties and on a study abroad. What I heard from onlookers of my situation went something like this… Janie is crazy, anyone mormon who gets married that young is just wanting to have sex right?… She's got her whole life to be married why doesn't she wait a couple years?… Or she doesn't even know him that well I hope they stay together. Luckily, I knew that I didn't need to listen to those who really didn't know anything about my relationship with Chris. Chris as my family can attest has made me a better person spiritually and given me more maturity. I didn't want Chris to be the one I skipped over because I was too young and not ready.
My answer came from my Grandma Marcia Egan, the person I look up to most. My grandmother helped me realize that heavenly father recognizes strength and a will to do good in every single one of his children. When asking her what she thought about me getting married she responded with such poise that I wondered if the Lord had let her know I was in need of some help. Her reply: "Well Janie, you have to consider a couple things while deciding to get married… 1. Does he love God? 2. Does he plan for the future and want a family? 3. Does he work hard? and 4. Are you attracted to him?" It was put so simply for me that it felt like a NO BRAINER (what my dad would say). I knew that Chris would give me a marriage that would be solidified in the Temple, that our relationship could continue to grow with the help of the Lord through trials and good times, and that we could raise children as a sealed family. YES, Chris loves his Heavenly Father. I also had the surety that Chris and I would be equal partners in our family and that we could pave the path for future together. YES, Chris wants to have a family and share our burdens and triumphs in life. Chris is one of the most determined and dedicated people I know. Chris does his best in every aspect of his life. YES, Chris works hard and will his whole life. Chris is also pretty cute and charming. YES, Chris is DANG attractive. After this discussion with my 92 year old grandma I realized that Heavenly Father left the decision up to me. I didn't need to wait for a sign nor did I need to pray until it felt completely perfect. My answer from God was "I trust you Janie and I will support and bless you in whatever you decide." So I took a leap of faith and married Chris who is now my eternal companion. We've barely been married three months (you could say we're seasoned pros). I am happy to say that I am loving being a wife and am excited to be a mother (NOT ANYTIME SOON) and that I have made covenants with the Lord that will strengthen me and my family. No there haven't been tremendously hard times yet, but I know there will be and I am blessed to have Chris by my side to lighten the load. Who is to say one person may be more ready than another to get married? Honestly, we are all just kids who grew up too fast.


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Main Page
Welcome to the Ball State University Libraries Wiki
The MediaWiki application was updated to version 1.23 on August 28, 2014. MediaWiki is the platform for the University Libraries' wiki. If you experience an problems with this application, please contact Brad Faust.
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- an oral drug (trade name Lipitor) that is effective in lowering triglycerides; potent in reducing LDL cholesterol because higher doses can be given (同)Lipitor
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/02 19:49:37」(JST)
wiki en
|Systematic (IUPAC) name
|(3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
|Clinical data
|Trade names
|Licence data
|US Daily Med:link
|Pregnancy cat.
|Legal status
|Prescription Only (S4) (AU) POM (UK) ℞-only (US)
|Pharmacokinetic data
|Hepatic - CYP3A4
|14 h
|CAS number
|ATC code
|PDB ligand ID
|117 (PDBe, RCSB PDB)
|Chemical data
|Mol. mass
|N (what is this?) (verify)
Atorvastatin (INN) /əˌtɔrvəˈstætən/, marketed by Pfizer as a calcium salt under the trade name Lipitor,[1] is a member of the drug class known as statins, which are used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.
Atorvastatin was discovered by Bruce Roth and coworkers at Parke-Davis,[2][3] since acquired by Warner-Lambert and then Pfizer.[4][5][6] Although atorvastatin was the fifth drug in the class of statins to be developed, clinical trials showed that atorvastatin caused a more dramatic reduction in LDL-C than the other statin drugs. From 1996 to 2012 under the trade name Lipitor, atorvastatin became the world's best-selling drug of all time, with more than $125 billion in sales over approximately 14.5 years.[7]
When Pfizer's patent on Lipitor expired on 30 November 2011,[8] generic atorvastatin became available in the United States. Initially, atorvastatin was manufactured only by generic drugmakers Watson Pharmaceuticals and India's Ranbaxy Laboratories. Prices for the generic version did not drop to the level of other generics—$10 or less for a month's supply—until other manufacturers were able to supply the drug in May 2012.[9]
- 1 Medical uses
- 1.1 Dyslipidemia
- 1.2 Cardiovascular disease
- 1.3 Other Uses
- 2 Administration
- 2.1 Specific populations
- 3 Contraindications
- 4 Adverse effects
- 4.1 Major
- 4.2 Common
- 4.3 Interactions
- 5 Mechanism of Action
- 6 Pharmacodynamics
- 7 Pharmacokinetics
- 7.1 Absorption
- 7.2 Distribution
- 7.3 Metabolism
- 7.4 Excretion
- 8 Pharmacogenetics
- 9 Chemical synthesis
- 10 Formulations
- 11 Drug recall
- 12 References
- 13 Further reading
- 14 External links
Medical uses
The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease:[10]
- Hypercholesterolemia[11] (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson types IIa and IIb) to reduce total cholesterol, LDL-C,[12] apo-B,[13] triglycerides[14] levels, and CRP[15] as well as increase HDL levels.
- Heterozygous familial hypercholesterolemia[11] in pediatric patients
- Homozygous familial hypercholesterolemia[11][16]
- Hypertriglyceridemia (Fredrickson Type IV)
- Primary dysbetalipoproteinemia (Fredrickson Type III)
- Combined hyperlipidemia[17]
Cardiovascular disease
- Primary prevention of heart attack, stroke, and need for revascularization procedures in patients who have risk factors such as age, smoking, high blood pressure, low HDL-C, and a family history of early heart disease, but have not yet developed clinically evident coronary heart disease.[18]
- Secondary prevention of myocardial infarction, stroke, unstable angina,[19][20] and revascularization in people with established coronary heart disease.[21][22]
- Myocardial infarction and stroke prophylaxis in patients with type II diabetes[23][24][25]
Other Uses
There have been recent studies suggesting that high-dose statin therapy plays a plaque-stabilizing role in patients suffering from acute coronary syndrome and thrombotic stroke[26][27]
Atorvastatin may be used in combination with bile acid sequestrants and ezetimibe to increase the reduction in cholesterol levels. However, It is not recommended to combine statin drug treatment with certain other cholesterol-lowering drugs, particularly fibrates, because this may increase the risk of myopathy-related adverse effects.[18]
While many statin medications should be administered at bedtime for optimal effect, atorvastatin can be dosed at any time of day, as long as it is continually dosed once daily at the same time.[28][29]
Specific populations
- Geriatric: Plasma concentrations of atorvastatin in healthy elderly subjects are higher than those in young adults, and clinical data suggests a greater degree of LDL-lowering at any dose for patients in the population as compared to young adults.[18]
- Pediatric: Pharmacokinetic data is not available for this population.[18]
- Gender: Plasma concentrations are generally higher in women than in men, but there is no clinically significant difference in the extent of LDL reduction between men and women.[18]
- Renal Impairment: Renal disease has no influence on plasma concentrations of atorvastatin and dosing need not be adjusted in these patients.[18]
- Hemodialysis: Hemodialysis will not significantly alter drug levels or change clinical effect of atorvastatin.[18]
- Hepatic Impairment: In patients with chronic alcoholic liver disease, levels of atorvastatin may be significantly increased depending upon the extent of liver disease.[18]
- Active liver disease: cholestasis, hepatic encephalopathy, hepatitis, and jaundice
- Unexplained elevations in AST or ALT levels
- Pregnancy: Atrovastatin may cause fetal harm by affecting serum cholesterol and triglyceride levels, which are essential for fetal development.[18]
- Breastfeeding: Small amounts of other statin drugs have been found to pass into breast milk, although atorvastatin has not been studied, specifically.[18]
- Markedly elevated CPK levels or if a myopathy is suspected or diagnosed after dosing of atorvastatin has begun. Very rarely, atorvastatin may cause rhabdomyolysis,[30] and it may be very serious leading to acute renal failure due to myoglobinuria. If rhabdomyolysis is suspected or diagnosed, atorvastatin therapy should be discontinued immediately.[31] The likelihood of developing a myopathy is increased by the co-administration of cyclosporine, fibric acid derivatives, erythromycin, niacin, and azole antifungals.[32]
Adverse effects
- Myopathy with elevation of creatinine kinase (CK)[33] and rhabdomyolysis are the most serious side effects, occurring rarely at a rate of <1% of patients taking atorvastatin.[17][32] As mentioned previously, atorvastatin should be discontinued immediately if this occurs.
- Liver Enzyme Abnormalities occurred in 0.7% of patients who received atorvastatin in clinical trials. It is recommended that hepatic function be assessed with laboratory tests before beginning atorvastatin treatment and repeated as clinically indicated thereafter. If evidence of serious liver injury occurs while a patient is taking atorvastatin, it should be discontinued and not restarted until the etiology of the patient's liver dysfunction is defined. If no other cause is found, atorvastatin should be discontinued permanently.[18]
The following have been shown to occur in 1–10% of patients taking atorvastatin in clinical trials:
- Headache[34]
- Weakness[32]
- Insomnia and dizziness[32]
- Chest pain and peripheral edema[32]
- Rash[32]
- Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, nausea[32]
- Urinary tract infection[32]
- Arthralgia, myalgia, back pain, arthritis[32]
- Sinusitis, pharyngitis, bronchitis, rhinitis[32]
- Infection, flu-like syndrome, allergic reaction[32]
Atorvastatin and other statins have been associated with anecdotal reports of memory loss in the postmarketing surveillance period. According to Pfizer, the manufacturer of Lipitor, clinical trials "do not establish a causal link between Lipitor and memory loss."[35][36][37][38]
High-dose atorvastatin have also been associated with worsening glycemic control.[38][39]
Interactions with clofibrate, fenofibrate, gemfibrozil, which are fibrates used in accessory therapy in many forms of hypercholesterolemia, usually in combination with statins, increase the risk of myopathy and rhabdomyolysis.[33][40][41]
Co-administration of atorvastatin with one of CYP3A4 inhibitors such as itraconazole,[42] telithromycin, and voriconazole, may increase serum concentrations of atorvastatin, which may lead to adverse reactions. This is less likely to happen with other CYP3A4 inhibitors such as diltiazem, erythromycin, fluconazole, ketoconazole, clarithromycin, cyclosporine, protease inhibitors, or verapamil,[43] and only rarely with other CYP3A4 inhibitors, such as amiodarone and aprepitant.[31] Often, bosentan, fosphenytoin, and phenytoin, which are CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. Only rarely, though, barbiturates, carbamazepine, efavirenz, nevirapine, oxcarbazepine, rifampin, and rifamycin,[44] which are also CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. Oral contraceptives increased AUC values for norethindrone and ethinyl estradiol; these increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin.[45]
Antacids can rarely decrease the plasma concentrations of statin drugs, but do not affect the LDL-C-lowering efficacy.[46]
Niacin also is proved to increase the risk of myopathy or rhabdomyolysis.[31]
Statins may also alter the concentrations of other drugs, such as warfarin or digoxin, leading to alterations in effect or a requirement for clinical monitoring.[31]
Vitamin D supplementation lowers atorvastatin and active metabolite concentrations, yet synergistically reduces LDL and total cholesterol concentrations.[47] Grapefruit juice components are known inhibitors of intestinal CYP3A4.
Co-administration of grapefruit juice with atorvastatin may cause an increase in Cmax and AUC, which can lead to adverse reactions or overdose toxicity.[48]
A few cases of myopathy have been reported when atorvastatin is given with colchicine.[18]
Mechanism of Action
As with other statins, atorvastatin is a competitive inhibitor of HMG-CoA reductase. Unlike most others, however, it is a completely synthetic compound. HMG-CoA reductase catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) to mevalonate, which is the rate-limiting step in hepatic cholesterol biosynthesis. Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing expression of low-density lipoprotein receptors (LDL receptors) on hepatocytes. This increases LDL uptake by the hepatocytes, decreasing the amount of LDL-cholesterol in the blood. Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of HDL-cholesterol.
Recent studies have shown that in patients suffering from acute coronary syndrome, high-dose statin treatment may play a plaque-stabilizing role. At high doses, statins have anti-inflammatory effects, incite reduction of the necrotic plaque core, and improve endothelial function, leading to plaque stabilization and, sometimes, plaque regression. However, there is an increased risk of statin-associated adverse effects with such high-dose statin treatment.[26] There is a similar thought process and risks associated with using high-dose statins to prevent recurrence of thrombotic stroke.[27]
The liver is the primary site of action of atorvastatin, as this is the principal site of both cholesterol synthesis and LDL clearance. It is the dosage of atorvastatin, rather than systemic drug concentration, which correlates with extent of LDL-C reduction.[18]
Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration (Tmax) of 1–2 h. The absolute bioavailability of the drug is about 14%, but the systemic availability for HMG-CoA reductase activity is approximately 30%. Atorvastatin undergoes high intestinal clearance and first-pass metabolism, which is the main cause for the low systemic availability. Administration of atorvastatin with food produces a 25% reduction in Cmax (rate of absorption) and a 9% reduction in AUC (extent of absorption), although food does not affect the plasma LDL-C-lowering efficacy of atorvastatin. Evening dose administration is known to reduce the Cmax and AUC by 30% each. However, time of administration does not affect the plasma LDL-C-lowering efficacy of atorvastatin.
The mean volume of distribution of atorvastatin is approximately 381 L. It is highly protein bound (≥98%), and studies have shown it is likely secreted into human breastmilk.
Atorvastatin metabolism is primarily through cytochrome P450 3A4 hydroxylation to form active ortho- and parahydroxylated metabolites, as well as various beta-oxidation metabolites. The ortho- and parahydroxylated metabolites are responsible for 70% of systemic HMG-CoA reductase activity. The ortho-hydroxy metabolite undergoes further metabolism via glucuronidation. As a substrate for the CYP3A4 isozyme, it has shown susceptibility to inhibitors and inducers of CYP3A4 to produce increased or decreased plasma concentrations, respectively. This interaction was tested in vitro with concurrent administration of erythromycin, a known CYP3A4 isozyme inhibitor, which resulted in increased plasma concentrations of atorvastatin. It is also an inhibitor of cytochrome 3A4.
Atorvastatin is primarily eliminated via hepatic biliary excretion, with less than 2% recovered in the urine. Bile elimination follows hepatic and/or extrahepatic metabolism. There does not appear to be any entero-hepatic recirculation. Atorvastatin has an approximate elimination half-life of 14 h. Noteworthy, the HMG-CoA reductase inhibitory activity appears to have a half-life of 20–30 h, which is thought to be due to the active metabolites. Atorvastatin is also a substrate of the intestinal P-glycoprotein efflux transporter, which pumps the drug back into the intestinal lumen during drug absorption.[31]
In hepatic insufficiency, plasma drug concentrations are significantly affected by concurrent liver disease. Patients with A-stage liver disease show a four-fold increase in both Cmax and AUC. Patients with B-stage liver disease show a 16-fold increase in Cmax and an 11-fold increase in AUC.
Geriatric patients (>65 years old) exhibit altered pharmacokinetics of atorvastatin compared to young adults, with mean AUC and Cmax values that are 40% and 30% higher, respectively. Additionally, healthy elderly patients show a greater pharmacodynamic response to atorvastatin at any dose; therefore, this population may have lower effective doses.[32]
Several genetic polymorphisms have been found to be associated with a higher incidence of undesirable side effects of atorvastatin. This phenomenon is suspected to be related to increased plasma levels of pharmacologically active metabolites, such as atorvastatin lactone and p-hydroxyatorvastatin. Atorvastatin and its active metabolites may be monitored in potentially susceptible patients using specific chromatographic techniques.[49]
Chemical synthesis
The first synthesis of atorvastatin at Parke-Davis that occurred during drug discovery was racemic followed by chiral chromatographic separation of the diastereomers. An early enantioselective route to atorvastatin made use of a ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a diastereoselective aldol reaction.[3][50] Once the compound entered pre-clinical development, process chemistry developed a cost-effective and scaleable synthesis.[3] In atorvastatin's case, a key element of the overall synthesis was ensuring stereochemical purity in the final drug substance, and hence establishing the first stereocenter became a key aspect of the overall design. The final commercial production of atorvastatin relied on a chiral pool approach, where the stereochemistry of the first alcohol functional group was carried into the synthesis—through the choice of isoascorbic acid, an inexpensive and easily sourced plant-derived natural product.[3][51]
Atorvastatin calcium tablets are marketed by Pfizer under the trade name Lipitor[52] for oral administration. Tablets are white, elliptical, and film-coated. Pfizer also packages the drug in combination with other drugs, such as with Caduet.[53] Pfizer recommends that patients do not break tablets in half to take half-doses, even when this is recommended by their doctors. When Pfizer's patent on Lipitor expired on 30 November 2011,[8] generic Atorvastatin became available in the United States. In some countries, atorvastatin calcium is made in tablet form by generic drug makers under various brand names including Stator, Atorvastatin Teva, Litorva, Torid, Atoris, Atorlip,Mactor, Lipvas, Sortis, Torvast, Torvacard, Totalip, and Tulip.[54] Pfizer also makes its own generic version under the name Zarator, which is the sole Pharmac-subsidised brand of atorvastatin in New Zealand.[55]
Drug recall
On 9 November 2012, Indian drugmaker Ranbaxy Laboratories Ltd. voluntarily recalled 10-, 20- and 40-mg doses of its generic version of atorvastatin in the United States. The lots of atorvastatin, packaged in bottles of 90 and 500 tablets, were recalled due to possible contamination with very small glass particles similar to the size of a grain of sand (less than 1 mm in size). Despite the contamination, the FDA received no reports of injury.[56]
- ^ "Pfizer product promotion page (Liptor)". Retrieved 2011-12-05.
- ^ US patent 4681893, Roth BD, "Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis", issued 1987-07-21
- ^ a b c d Roth BD (2002). "The discovery and development of atorvastatin, a potent novel hypolipidemic agent". Prog Med Chem. Progress in Medicinal Chemistry 40: 1–22. doi:10.1016/S0079-6468(08)70080-8. ISBN 978-0-444-51054-9. PMID 12516521.
- ^ Milton L. Hoefle (2000). "The Early History of Parke-Davis and Company". Bull. Hist. Chem. 25 (1): 28–34.
- ^ "Pfizer Gets Its Deal to Buy Warner-Lambert for $90.2 Billion". New York Times. 2000.
- ^ John Simons (20 January 2003). "The $10 Billion Pill Hold the fries, please. Lipitor, the cholesterol-lowering drug, has become the bestselling pharmaceutical in history. Here's how Pfizer did it". Fortune Magazine.
- ^ "Lipitor becomes world's top-selling drug". Crain's New York Business. 2011-12-28.
- ^ a b CNN Wire Staff (30 November 2011). "Lipitor loses patent, goes generic". CNN. Retrieved 18 November 2012.
- ^ "Price to UK for 28 tablets from £3.25 (10mg) to £10.00 (80mg)". National Health Service. June 2012.
- ^ "Atorvastatin Calcium". Drugs.com. Retrieved 3 April 2011.
- ^ a b c McCrindle BW, Ose L, Marais AD (July 2003). "Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial". J. Pediatr. 143 (1): 74–80. doi:10.1016/S0022-3476(03)00186-0. PMID 12915827.
- ^ Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, Schoenhagen P, Crowe T, Cain V, Wolski K, Goormastic M, Tuzcu EM (April 2006). "Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial". Journal of the American Medical Association 295 (13): 1556–65. doi:10.1001/jama.295.13.jpc60002. PMID 16533939.
- ^ Nawrocki JW, Weiss SR, Davidson MH, Sprecher DL, Schwartz SL, Lupien PJ, Jones PH, Haber HE, Black DM (May 1995). "Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor". Arterioscler. Thromb. Vasc. Biol. 15 (5): 678–82. doi:10.1161/01.ATV.15.5.678. PMID 7749881.
- ^ Bakker-Arkema RG, Davidson MH, Goldstein RJ, Davignon J, Isaacsohn JL, Weiss SR, Keilson LM, Brown WV, Miller VT, Shurzinske LJ, Black DM (January 1996). "Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia". Journal of the American Medical Association 275 (2): 128–33. doi:10.1001/jama.1996.03530260042029. PMID 8531308.
- ^ Ozaki K, Kubo T, Imaki R, Shinagawa H, Fukaya H, Ohtaki K, Ozaki S, Izumi T, Aizawa Y (August 2006). "The anti-atherosclerotic effects of lipid lowering with atorvastatin in patients with hypercholesterolemia". J. Atheroscler. Thromb. 13 (4): 216–9. doi:10.5551/jat.13.216. PMID 16908955.
- ^ Marais AD, Firth JC, Bateman ME, Byrnes P, Martens C, Mountney J (August 1997). "Atorvastatin: an effective lipid-modifying agent in familial hypercholesterolemia". Arterioscler. Thromb. Vasc. Biol. 17 (8): 1527–31. doi:10.1161/01.ATV.17.8.1527. PMID 9301631.
- ^ a b Rossi S, ed. (2006). Australian medicines handbook 2006. Adelaide, S. Aust: Australian Medicines Handbook Pty Ltd. ISBN 0-9757919-2-3.
- ^ a b c d e f g h i j k l m "LIPITOR (atorvastatin calcium) Tablets for oral administration" (PDF). Full Prescribing Information. Pfizer Inc. Retrieved 18 April 2014.
- ^ Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J (April 2003). "Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial". Lancet 361 (9364): 1149–58. doi:10.1016/S0140-6736(03)12948-0. PMID 12686036.
- ^ Law MR, Wald NJ, Rudnicka AR (June 2003). "Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis". BMJ 326 (7404): 1423. doi:10.1136/bmj.326.7404.1423. PMC 162260. PMID 12829554.
- ^ Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (May 1998). "Prediction of coronary heart disease using risk factor categories". Circulation 97 (18): 1837–47. doi:10.1161/01.CIR.97.18.1837. PMID 9603539.
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- ^ Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, Fuller JH (2004). "Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial". Lancet 364 (9435): 685–96. doi:10.1016/S0140-6736(04)16895-5. PMID 15325833.
- ^ Neil HA, DeMicco DA, Luo D, Betteridge DJ, Colhoun HM, Durrington PN, Livingstone SJ, Fuller JH, Hitman GA (November 2006). "Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS)". Diabetes Care 29 (11): 2378–84. doi:10.2337/dc06-0872. PMID 17065671.
- ^ Gentile S, Turco S, Guarino G, Sasso CF, Amodio M, Magliano P, Salvatore T, Corigliano G, Agrusta M, De Simone G, Gaeta I, Oliviero B, Torella R (December 2000). "Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 diabetic patients with hypercholesterolaemia". Diabetes Obes Metab 2 (6): 355–62. doi:10.1046/j.1463-1326.2000.00106.x. PMID 11225965.
- ^ a b Rosa GM, Carbone F, Parodi A, Massimelli EA, Brunelli C, Mach F, Vuilleumier N, Montecucco F (2014). "Update on the efficacy of statin treatment in acute coronary syndromes". Eur. J. Clin. Invest. 44 (5): 501–15. doi:10.1111/eci.12255. PMID 24601937.
- ^ a b Furie KL (2012). "High-dose statins should only be used in atherosclerotic strokes". Stroke 43 (7): 1994–5. doi:10.1161/STROKEAHA.111.633339. PMID 22581818.
- ^ "Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)". JAMA 285 (19): 2486–97. 2001. doi:10.1001/jama.285.19.2486. PMID 11368702.
- ^ Grundy SM, Cleeman JI, Merz CN, Brewer HB, Clark LT, Hunninghake DB, Pasternak RC, Smith SC, Stone NJ (2004). "Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines". Circulation 110 (2): 227–39. doi:10.1161/01.CIR.0000133317.49796.0E. PMID 15249516.
- ^ Hermann M, Bogsrud MP, Molden E, Asberg A, Mohebi BU, Ose L, Retterstøl K (June 2006). "Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy". Clin. Pharmacol. Ther. 79 (6): 532–9. doi:10.1016/j.clpt.2006.02.014. PMID 16765141.
- ^ a b c d e Williams D, Feely J (2002). "Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors". Clin Pharmacokinet 41 (5): 343–70. doi:10.2165/00003088-200241050-00003. PMID 12036392.
- ^ a b c d e f g h i j k l Lipitor: Prescribing Information. Pfizer. June 2009.
- ^ a b Ghirlanda G, Oradei A, Manto A, Lippa S, Uccioli L, Caputo S, Greco AV, Littarru GP (March 1993). "Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study". J Clin Pharmacol 33 (3): 226–9. doi:10.1002/j.1552-4604.1993.tb03948.x. PMID 8463436.
- ^ Finegold JA, Manisty CH, Goldacre B, Barron AJ, Francis DP (2014). "What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice". Eur J Prev Cardiol 21 (4): 464–74. doi:10.1177/2047487314525531. PMID 24623264.
- ^ Wagstaff LR, Mitton MW, Arvik BM, Doraiswamy PM (July 2003). "Statin-associated memory loss: analysis of 60 case reports and review of the literature". Pharmacotherapy 23 (7): 871–80. doi:10.1592/phco.23.7.871.32720. PMID 12885101.
- ^ "The side effects of statins: Heart healthy and head harmful?". Michael O'Riordan. HeartWire. 12 February 2008. Retrieved 22 October 2010
- ^ O'Riordan M (2010-10-22). "The side effects of statins: Heart healthy and head harmful?". The Wall Street Journal. Retrieved 2010-10-24.
- ^ a b Mayo Clinic Staff. "Statin Side Effects: Weigh the Risks and Benefits". The Mayo Clinic. Retrieved 19 April 2014.
- ^ Kostapanos MS, Liamis GL, Milionis HJ, Elisaf MS (September 2010). "Do statins beneficially or adversely affect glucose homeostasis?". Curr Vasc Pharmacol 8 (5): 612–31. doi:10.2174/157016110792006879. PMID 20507274.
- ^ Steiner G (December 2007). "Atherosclerosis in type 2 diabetes: a role for fibrate therapy?". Diab Vasc Dis Res 4 (4): 368–74. doi:10.3132/dvdr.2007.067. PMID 18158710.
- ^ Graham DJ, Staffa JA, Shatin D, Andrade SE, Schech SD, La Grenade L, Gurwitz JH, Chan KA, Goodman MJ, Platt R (December 2004). "Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs". Journal of the American Medical Association 292 (21): 2585–90. doi:10.1001/jama.292.21.2585. PMID 15572716.
- ^ Mazzu AL, Lasseter KC, Shamblen EC, Agarwal V, Lettieri J, Sundaresen P (October 2000). "Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin". Clin. Pharmacol. Ther. 68 (4): 391–400. doi:10.1067/mcp.2000.110537. PMID 11061579.
- ^ Neuvonen PJ, Niemi M, Backman JT (December 2006). "Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance". Clin. Pharmacol. Ther. 80 (6): 565–81. doi:10.1016/j.clpt.2006.09.003. PMID 17178259.
- ^ Backman JT, Luurila H, Neuvonen M, Neuvonen PJ (August 2005). "Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites". Clin. Pharmacol. Ther. 78 (2): 154–67. doi:10.1016/j.clpt.2005.04.007. PMID 16084850.
- ^ "Lipitor". U.S. National Library of Medicine.
- ^ McKenney JM (2005). "Efficacy and safety of rosuvastatin in treatment of dyslipidemia". Am J Health Syst Pharm 62 (10): 1033–47. PMID 15901588.
- ^ Schwartz JB (February 2009). "Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence". Clin. Pharmacol. Ther. 85 (2): 198–203. doi:10.1038/clpt.2008.165. PMID 18754003.
- ^ Kane GC, Lipsky JJ (September 2000). "Drug-grapefruit juice interactions". Mayo Clinic Proceedings 75 (9): 933–42. doi:10.4065/75.9.933. PMID 10994829.
- ^ Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, Fuller JH, Livingstone S, Charlton-Menys V, Neil A, Poulter N, Sever P, Shields DC, Stanton AV, Chatterjee A, Hyde C, Calle RA, Demicco DA, Trompet S, Postmus I, Ford I, Jukema JW, Caulfield M, Hitman GA (May 2012). "Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)". J Lipid Res 53 (5): 1000–1011. doi:10.1194/jlr.P021113. PMC 3329377. PMID 22368281.
- ^ Roth BD, Blankley CJ, Chucholowski AW, Ferguson E, Hoefle ML, Ortwine DF, Newton RS, Sekerke CS, Sliskovic DR, Wilson M (1991). "Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus". J. Med. Chem. 34: 357–366. doi:10.1021/jm00105a056. .
- ^ Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth (2004). "Chapter 9. Atorvastatin Calcium (Lipitor)". Contemporary Drug Synthesis. John Wiley & Sons, Inc. pp. 113–125. ISBN 0-471-21480-9. .
- ^ Medical Product Reviews. "Atorvastatin Calcium (Lipitor Tablets) - Uses, Dosage and Side Effects". Retrieved 3 May 2012.
- ^ News Medical. "Lipitor - What is Lipitor?". Retrieved 3 May 2012.
- ^ "Pfizer 2008 Annual Report". Pfizer. 23 April 2009. Retrieved 7 August 2009.
- ^ Rapley, Lisa (31 May 2012). "Atorvastatin sole funding announced". PharmacyToday.co.nz. Retrieved 16 July 2014.
- ^ "FDA Statement on Ranbaxy Atorvastatin Recall". FDA. Retrieved 19 April 2014.
Further reading
- "Highlights of prescribing information" (pdf). Lipitor (atorvastatin calcium) Tablets for oral administration. Pfizer. 2009-06-01. Retrieved 2011-10-26.
- Maggon K (June 2005). "Best-selling human medicines 2002-2004". Drug Discov. Today 10 (11): 739–42. doi:10.1016/S1359-6446(05)03468-9. PMID 15922927.
- Simons J (2003-01-20). "The $10 Billion Pill Hold the fries, please. Lipitor, the cholesterol-lowering drug, has become the bestselling pharmaceutical in history. Here's how Pfizer did it". Fortune. Retrieved 2011-10-26.
- Winslow R (2000-01-24). "The Birth of a Blockbuster: Lipitor's Route out of the Lab". The Wall Street Journal. Retrieved 2011-10-26.
- "Ann Arbor chemist wins national award for drug discovery". ScienceBlog. American Chemical Society. 2003-03-01. Retrieved 2011-10-26.
- Rowe A (2008-08-20). "Meet the Guy Who Invented Lipitor". Wired Science. Wired.com. Retrieved 2011-10-26.
- Bernstein M (2008-08-16). "Chemical Society To Honor 'Heroes Of Chemistry' During National Meeting". Medical News Today. Retrieved 2011-10-26.
- He L (2003-09-27). "Bruce D. Roth, Pfizer Inc, USA". Chinese Academy of Sciences·Institute of Process Engineering. Retrieved 2011-10-26.
External links
- Atorvastatin bound to proteins in the PDB
- Lipitor.com – manufacturer's site
- MedlinePlus Drug information: Atorvastatin (Systemic) – information from USP DI Advice for the Patient
- U.S. National Library of Medicine: Drug Information Portal - Atorvastatin
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 心血管疾患または糖尿病患者におけるコレステロール低下に関する臨床試験 clinical trials of cholesterol lowering in patients with cardiovascular disease or diabetes
- 2. 急性冠症候群後の低比重リポ蛋白コレステロール(LDL)低下 low density lipoprotein cholesterol ldl c lowering after an acute coronary syndrome
- 3. 心血管疾患の二次予防における脂質低下療法の強度 intensity of lipid lowering therapy in secondary prevention of cardiovascular disease
- 4. スタチン:作用、副作用、および投与 statins actions side effects and administration
- 5. スタチン誘発性ミオパチー statin myopathy
English Journal
- MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression.
- Tabuchi T, Satoh M, Itoh T, Nakamura M.SourceDivision of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Iwate, Japan.
- Clinical science (London, England : 1979).Clin Sci (Lond).2012 Aug 1;123(3):161-71.
- Endothelial senescence is thought to play a role in CAD (coronary artery disease). miR-34a (microRNA-34a) and other SIRT1 (silent information regulator 1)-related miRs have recently been found to target SIRT1 leading to endothelial senescence. In the present study, we investigated whether SIRT1-rela
- Long-Term Impact of Multifactorial Treatment on New-Onset Diabetes and Related Cardiovascular Events in Metabolic Syndrome: A Post Hoc ATTEMPT Analysis.
- Athyros VG, Elisaf MS, Alexandrides T, Achimastos A, Ganotakis E, Bilianou E, Karagiannis A, Liberopoulos EN, Tziomalos K, Mikhailidis DP; for the Assessing the Treatment Effect in Metabolic Syndrome Without Perceptible Diabetes (ATTEMPT) Collaborative Group.Source1Department of Internal Medicine, Second Propedeutic Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
- Angiology.Angiology.2012 Jul;63(5):358-366. Epub 2011 Oct 17.
- This post hoc analysis of the Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT) study assesses the 3½ year incidence of new-onset diabetes (NOD) and related cardiovascular disease (CVD) events in patients with metabolic syndrome (MetS), after mult
Japanese Journal
- Selected Papers : Kovarnik T, Mintz GS, Skalicka H, et al : Virtual histology evaluation of atherosclerosis regression during atorvastatin and ezetimibe administration : HEAVEN study : Circ J 76 : 176-183, 2011 : HEAVEN試験について
- 室原 豊明
- Cardio-lipidology : 脂質代謝から考える心血管系 6(3), 122-124, 2012-12
- アトルバスタチンはロスバスタチンよりも急性冠症候群患者の腎機能低下を抑制する
- 桑原 昌則,近藤 史明,濱田 知幸 [他]
- 日本心臓病学会誌 : Journal of cardiology. Japanese edition 7(3), 194-198, 2012-10
- Combination Therapy of Atorvastatin and Amlodipine Inhibits Sympathetic Nervous System Activation and Improves Cognitive Function in Hypertensive Rats
- KISHI Takuya,SUNAGAWA Kenji
- Circulation journal : official journal of the Japanese Circulation Society 76(8), 1934-1941, 2012-07-25
- … biBackground:/i/b A previous study has demonstrated that orally administered atorvastatin reduces sympathetic nervous system (SNS) activation via an anti-oxidant in the rostral ventrolateral medulla (RVLM) of hypertensive rats, whereas amlodipine did not. … Furthermore, several previous reports have suggested that atorvastatin or amlodipine improves cognitive dysfunction during hypertension. …
Related Links
- Atorvastatin (INN) (pron.: /əˌtɔrvəˈstætən/), marketed by Pfizer as a calcium salt under the trade name Lipitor, is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes ...
- 2009年2月7日 ... リピトール(Lipitor)は、米ファイザー社が製造・販売する高脂血症治療薬...
- 多くの薬物を代謝するので薬物相互作用を起こしやすい。
- ニフェジピン
- シクロスポリン
- simvastatin
- cericastatin
- atorvastatin


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J. Geils sues the members of the J. Geils Band
It looks as if the relationship between guitarist J. Geils and the band that bears his name is broken beyond repair.
Ten days after the J. Geils Band announced plans to tour without John Geils Jr. — better known to fans as J. — an attorney representing the guitarist has filed a lawsuit accusing his bandmates, Peter Wolf, Seth Justman, Magic Dick, and Danny Klein, of trademark infringement and deceptive business practices.
The 44-page suit filed Wednesday in US District Court in Boston claims that Geils owns the "J. Geils Band'' trademark, and the band is "seeking to misappropriate and steal'' the name from Geils by touring without him.
"Mr. Geils has this trademark and never transferred it to anybody,'' said attorney Chuck Grimes, who represents Geils. "These guys performed in Mr. Geils's band, but that doesn't give them the right to grab the name.''
James Weinberger, the attorney for the other band members, said Wednesday he hadn't seen the lawsuit and could not comment.
Fans of the band were more than a little confused last month when the band, whose hits include "Musta Got Lost'' and "Freeze-Frame,'' announced plans to tour without their namesake. In a statement, the band said the split was the result of an "ongoing legal dispute'' between Geils and the other members over the rights to the name J. Geils Band.
Geils applied to the US Patent and Trademark Office for the "J. Geils Band'' trademark in 2008, and was awarded it a year later. Weinberger said Geils sought the trademark without telling Wolf or the others.
"He did this and nobody knew about it,'' Weinberger said. "That's a pretty strong affront.''
The lawsuit lays out the long history of the J. Geils Band, beginning in 1967 or so, when Geils, Klein, and Magic Dick performed as the J. Geils Blues Band. Wolf and Justman, who would become the group's principal songwriters, joined in 1969.
Over the years, however, even as the band became more popular (thanks to the song "Centerfold,'' the "Freeze-Frame'' LP reached No. 1 in 1981), Geils was restless and twice tried to quit the band, according to the lawsuit. In 1982, the suit claims, he was "forced under extreme pressure'' to sign a document that prevented band members — or "shareholders'' — from using "J. Geils Band'' for a commercial purpose that didn't involve the rest of the band.
"That raises some confusion,'' Grimes acknowledged Wednesday. "But at the end of the day, the rights of Mr. Geils will be upheld over the rights of any other claimant. It's his name. There's nothing that would stop Wolf and Justman from billing themselves as 'formerly of the J. Geils Band.' That would be accurate.''


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Personal Website
Anil K Kashyap is the Edward Eagle Brown Professor of Economics and Finance at the University of Chicago Booth School of Business. His research focuses on banking, business cycles, corporate finance, price setting, and monetary policy. His research has won him numerous awards, including a Sloan Research Fellowship, the Nikkei Prize for Excellent Books in Economic Sciences, and a Senior Houblon-Norman Fellowship from the Bank of England.
Prior to joining the Chicago Booth faculty in 1991, Kashyap spent three years as an economist for the Board of Governors for the Federal Reserve System. He currently works as a consultant for the Federal Reserve Bank of Chicago, and serves as a member of the Economic Advisory Panel of the Federal Reserve Bank of New York, and as a Research Associate for the National Bureau of Economic Research (NBER). He is on the Board of Directors of the Bank of Italy's Einuadi Institute of Economics and Finance, is a member of the Squam Lake Group and serves on the International Monetary Fund's Advisory Group on the development of a macro-prudential policy framework. Since 2016 he has been an external member of the Bank of England's Financial Policy Committee.
Kashyap is also one of the academic members of the Bellagio Group (whose non-academic
members consist of the Deputy Central Bank Governors and Vice Ministers of Finance of the G7 countries). This experience, along with his research and other consulting and advising to central banks and finance ministries around the world, has helped him create his two unique elective courses, "Understanding Central Banks" and "The Analytics of Financial Crises."
Kashyap is a member of both the American Economic Association (AEA) and American Finance Association, and is a co-founder of the US Monetary Policy Forum. In 2014, was selected for the Emory Williams Award for teaching excellence by the Chicago Booth students.
He regularly speaks on financial crises, Japan, the global economy, and the direction of
economic policy.
He graduated from the University of California at Davis in 1982 with a bachelor's degree in
economics and statistics with highest honors. In 1989, he earned a PhD from the Massachusetts Institute of Technology. He enjoys rotisserie baseball and the Indianapolis 500.
Rotisserie baseball, the Indianapolis 500, and bridge.
Banking; business cycles; corporate finance; monetary policy.
To find Professor Kashyap's full list of publications go to
The University of Chicago Booth School of Business |
University of Chicago |
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The Long Goodbye
Starring Elliott Gould, Nina Van Pallandt, Sterling Hayden, Mark Rydell, Henry Gibson
Directed by Robert Altman
Running Time - 1:52
Genre - Drama
Opened in Theaters - Wednesday, March 7th, 1973 (16903 days ago)
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Rodent Control in Kleinskool
Port Elizabeth is a great breeding ground for rats, mice and other pest rodents. Weather you have a huge rat infestation in a factory or food handling facility or even a mouse or two living in your Kleinskool house roof, no job is too big or too small to handle.
Unfortunately rodents have been a growing problem here in Kleinskool and the need for control has never been greater. We have made extermination our business and specialize in it. Our Rat or mouse extermination service is second to none. We have attached an integrated pest management system to our service that assures fast, safe professional results. An integrated pest management system is where our servicemen and women are trained to identify all commonly found plague rodents and insects. Seek out their sources, apply a safe effective treatment and help implement measures based on our recommendations to keep them away.
Us at Port Elizabeth Pest Control are the experts in all aspects of structural pest control and fumigation in and around Kleinskool.
Here are some of the more common furry critters that one might find in your Kleinskool garden, some may not be rodents but may be mistaken for them.
- Black and brown rats
- Domestic mice as well as field mice
- Grey squirrels
- Gerbils
- Runner and dune moles
- shrews
There you have it, if you reside in Kleinskool and identify any of these creatures posing problem, give us a call and have a friendly professional member of our staff at your doorstep in no problem.


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Theodore Holford, PhD
Susan Dwight Bliss Professor of Biostatistics and Professor of Statistics and Data Science
Departments & Organizations
School of Public Health: Biostatistics | YSPH Global Health Concentration
Yale Cancer Center: Cancer Prevention and Control
Yale Institute for Global Health
Office of Cooperative Research
Theodore Holford, Ph.D, is Susan Dwight Bliss Professor of Epidemiology and Public Health (Biostatistics). His scholarly work involves the development and application of statistical methods in public health and the training of individuals developing careers in health research. He developed an approach for analyzing temporal trends in disease rates using the age-period-cohort modeling framework that has be used extensively in the analysis of cancer incidence and mortality trends. He currently has NCI funding for research that extends and applies his population model for lung cancer that can be used for evaluating cancer intervention strategies as part of the Cancer Intervention and Surveillance Modeling Network (CISNET). Ongoing research using this model focuses on quantifying the effects of cigarette smoking policy on lung cancer mortality, as well as effects of screening and treatment. He has developed and applied methods for using Geographic Information Systems (GIS) in environmental epidemiology. This work provides approaches for analyzing the effect of traffic related air pollution on childhood asthma. Finally, Dr. Holford has played a leading role in training both pre-doctoral and post-doctoral students in biostatistics and epidemiology, including assessment of the effects of environmental exposure on disease risk.
Education & Training
|Yale University (1973)
|Andrews University (1969)
|American College of Epidemiology
|American Statistical Association
Honors & Recognition
Eleanor Roosevelt International Cancer Fellowship from the UICC (International Union against Cancer) (1982)
Wakeman Award for Research in the Neurosciences


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Clay Jewelry Dish
Make Mom a marbled clay jewelry dish this Mother's Day, and surprise her with breakfast in bed.
Visit Original Photo
Custom Artisan Shower Tiles
This bathroom shower features tiles created by a local artisan. The built-in shelf features two green and cream-colored tiles made by clay stamps, and highlight pictures native to the home's coastal geography.
Small Details
"Use the existing lightbox and replace current ceiling lights with a pendant or chandelier of your choice," Ana suggests. In the kitchen, she added a pendant that matched the floor lamps and looked great off center.
A Fresh Start
Ana suggests asking your super to paint before move-in. Here, clean white walls set the foundation for furniture and accessories: a perfect contrast.
Modern White Kitchen Detail With Gold Wall Sconce And Floating Shelves With White Glass Tile
This modern white kitchen detail showcases its white marble countertops, white cabinets, floating shelves, modern gold sconce and hardware, and white glass herringbone tile backsplash.
White Chef Kitchen With Rustic Cutting Boards
Organic touches like hardwood floors and even rustic wood cutting boards warm up the look of the white-and-gray kitchen.
Gray Chef Kitchen With Dark Floors
Custom hardware for cabinet doors and drawers gives pretty flair to the gourmet kitchen. Dark wood floors are a handsome anchor to the light gray cabinets and pale backsplash.
White Kitchen With Marble Backsplash
For a family who loves cooking and crafts, it made more sense to use marble for a backsplash than countertops. On the wall, the marble adds visual dimension and a crisp, elegant effect.
Playful Custom Color Cabinets
Custom color cabinets, reclaimed wood shelving, smoked glass uppers, matte black and brass finishes, and postmodern pops make this space completely unique. It's a fun space that's meant to be fresh, inviting, and playful without sacrificing any amenity!
Black Tile Backsplash and Open Cabinets
This kitchen features black tile backslpash, new countertops, and unique open cabinets, as seen on Fixer Upper.
Dark Blue Kitchen With Dramatic Black Marble Backsplash
Whereas the rest of the condo is light and airy, the eat-in kitchen is dark and moody. To create this dramatic look, designer Caitlin Murray painted the cabinets blue and brought in a gorgeous, black marble backsplash.
Living Room With a Velvet Sofa and Copper Tin Ceiling
This eclectic living room evokes glamour with a mix of styles, shapes, colors and tones. The custom blue, velvet sofa is the focal point and balances the room with an elegant chandelier highlighting the copper tin ceiling.
Cozy Cottage Kitchen With Gingham Shelf Liner
Give your kitchen a colorful makeover on the cheap with cheery blue-and-white gingham shelf liner.
13 Ways to Add Holiday Flair to Your Front Porch in Ten Minutes: Grouped Lanterns
Add some old world charm to your front porch with a grouping of different glass front lanterns ranging in size and finish. The flames will add instant ambience and warmth to your entry.
Covered Patio With Arched Doorway and Exposed Ceiling Beams
This covered patio lets you enjoy the great outdoors in style. Exposed ceiling beams highlight the home's architectural style, while an open arched doorway to the backyard mirrors the arched doorways into the house.
SCAD Builds a Garden
The bee is the Savannah College of Art and Design's mascot, "a unique icon of industry" says SCAD president Paula Wallace. The bee is also the star of a new organic garden and apiary legacy project and teaching tool at the college where students can learn about a host of relevant topics including garden design; sustainability; use of plants in beauty and fragrance products; the use of beeswax in jewelry-making and painting; and how to dye fabrics using plants. In just about every way SCAD Back40 is the perfect, holistic teaching tool and laboratory for a school perpetually expanding its approach to incorporating real world practices into its curriculum. Pictured: a bee pollinating anise hyssop.
Explosion of Color
Featured in this raised bed is an appealing cacophony of color including hot pink dianthus (a type of sweet William); lighter pink yarrow (Achillea Millefolium); hot pink salvia in the background; golden coleus 'Wizard' in the foreground and 'Sunshine' ligustrum, miniature to the left and right.
Raised Beds
Brick raised beds and bamboo trellises make this organic garden as attractive as it is functional.
Contemporary Kitchen With Modern Walk-in Pantry
This contemporary kitchen has a large walk-in pantry built into the cabinetry for optimal hidden storage space. Just outside the pantry, a marble backsplash and sleek kitchen island complete the modern look of the space.


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Who Was Chuck Taylor?
By Abraham Aamidor, author of "Chuck Taylor, All Star: The True Story of the Man Behind the Most Famous Athletic Shoe in History," published by Indiana University Press on March 1, 2006. Foreword by Dean Smith and available from all bookstores or at www.amazon.com or www.iupress.indiana.edu, or www.bn.com, then type in "aamidor" or "chuck taylor all star" in the search window. This is the first full-length, all-original biography of Taylor, and corrects many historical errors in shorter articles on the man.
Who was Chuck Taylor? "The man's biography begins and ends with his name," Orange County Register columnist John Hughes once declared.
Not quite – Chuck Taylor was quite real. He played his first professional basketball game in March, 1919, while still a high school student in Columbus, Ind. He was 17 years old.
By the mid-1920s he was player-manager of a stellar group of cagers who shot hoops for the Converse All-Stars barnstorming team. The team traveled throughout the Midwest and featured Carlyle Friddle, one of the stars on the Franklin (Ind.) High School and college "Wonder Five."
During World War II Chuck joined middle-aged high school and college coaches who worked as physical fitness instructors and coaches for the Army and the Navy. Chuck was a physical fitness instructor at a Navy "pre-flight" program at Marquette University coached the wonderful Wright Field Air-Tecs in 1944-45, at what is now Wright-Patterson Air Force Base in Dayton, Ohio.
College All-Americans and future NBA players such as Long John Mahnken, Big Ed Sadowski, Dwight "Dike" Eddleman, Bruce Hale, Al Negratti, Johnny Schick and others played for him.
Born Charles Hollis Taylor in rural Brown County in 1901, Chuck always wanted to be a star basketball player, and he almost was. His best team was the Akron Firestone Non-Skids in the early 1920s. The Non-Skids were an "industrial league" team, but in 1937 they were charter members with the Akron Goodyear Wingfoots and the Fort Wayne G.E. Techs in creating the National Basketball League. Though the Non-Skids folded during World War II, the National Basketball League merged with the Basketball Association of America in 1949 to form the NBA.
Chuck's signature – that's what most people know of him – was added to the Converse All Star shoe in 1932, after a series of business reversals for the company. Chuck, who had promoted himself via the Converse barnstorming team, and who had hosted countless "clinics" in high school and college basketball gyms across the country where he almost single-handedly taught Americans the fundamentals of basketball, became the new brand name for the shoe.
He started his All-American picks at this time, too. They were highly regarded because Chuck only selected players he had personally seen play, and he found talent in small Southeastern and Southwestern colleges where big-city sportswriters never went. He had a good eye, and his picks always were touted in the popular Converse Basketball Yearbook.
Chuck had his dark side, though. He, and his employer, often claimed that he was a veteran of the "World Champion" Original Celtics from New York City and "Olympic champion" Buffalo Germans. He was neither, but the myth helped sell shoes. And in 1957, he put on a basketball clinic at Westminster College in Fulton, Mo., then ran off the with the athletic director's wife. "He had women everywhere," said long-time associate Joe Dean, retired athletic director at Louisiana State University.
No matter. His iconic shoe is part of Americana – look for it in the popular movie "Hoosiers," or on Larry Bird's feet while making a jump shot in high school, or as a popular, uniquely unisex "lifestyle" shoe everywhere.


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This star rating is the opinion of the property owner only. A Self-Rated hotel has not been assessed by the AA or Visit Britain, whose official star ratings we use across LateRooms.com.
Beausejour Montmartre4 Self rated
6 rue Lecluse, Paris, 75017
Price FromView Rooms
- Very Good
- 39 guest reviews
"Lovely clean hotel, great staff , great location for eating out..."
"great wine!!!! lovely little hotel that is a gem hidden away. excellent accommodation for business or a get away with the wife!!..."
"I love the modern simplicity of the hotel. It was an oasis after a few B&Bs here and there. The price is worth the product...."
"Nice place. Staff is very nice and friendly. Very convenient location wise. 15mins from the Champs Elysees and 10 mins away by tube from gar..."
"My partner and I stayed in this hotel for 2 nights and could not really fault it. We booked it literally 15 mins before arriving due to an i..."
About the hotel
Boasting a beautiful exotic garden with palm trees in the heart of Paris, The Beausejour Montmartre welcomes you for your Paris break The Beauséjour Montmartre is located between the Place de l'Etoile and Sacré Coeur, close to Place de Clichy Metro station in the lively Montmartre district of Paris. The rooms have free Wi-Fi, satellite TV, marble bathrooms fitted with a shower. they also include a minibar and an iPod dock is available upon request.
The beautiful lounge bar and stunning garden setting serve as a welcome respite after a long day sightseeing in Paris. The Hotel Beausejour Montmartre provides a 24-hour reception.
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- Main
- Air conditioning in rooms, 24 Hour Reception, Cots available, Safety Deposit Box, Minibar in each room, Telephone In Each Room, 24 Hour Room Service, Concierge, Wake Up Call Available, Doctor on call, Ground floor bedrooms, Lift to all floors, Public Air Conditioning
- Business
- Wi-Fi Available, In-room Broadband, In-room Modem Hook up, Wi-Fi Available In Public Areas, Wi-Fi Available In Rooms
- In Room Entertainment
- TV, Satellite TV
- Dining
- Bar, Breakfast to go
- Leisure
- [Channels] News, [Channels] Sky Sports, [Channels] Foreign (European), [Channels] Foreign (Other), [Channels] Music, [Channels] Childrens
Useful Info Show/hide
- From 14:00 hours
- By 11:00 hours
- Up to 12 years old
- The LateRooms.com rate for Beausejour Montmartre in Paris is the total price of the room and not the 'per person' rate. All taxes are included, with the exception of city tax, which will be charged at 2.47(EUR) per person per night and is payable to the hotel directly.
- Pets are not allowed
Customer Reviews
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Very Good
92% would recommend it to a friend
Customer service
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Great hotel and staff
Lovely clean hotel, great staff , great location for eating out...
this is a really excellent hotel with a feel of a much more expensive hotel.
great wine!!!.
lovely little hotel that is a gem hidden away. excellent accommodation for business or a get away with the wife!!...
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9 Am visit to Hoover Dam...before the tour buses arrive - on the Nevada side.
Hoover Dam, originally known as Boulder Dam, is a concrete arch-gravity dam in the Black Canyon of the Colorado River, on the border between the U.S. states of Arizona and Nevada. When completed in 1935, it was both the world's largest electric-power generating station and the world's largest concrete structure.


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Walton Bridge Breakfast Club
Sunday 5th June 2016
08:00hrs - 12:00hrs (approx)
Walton Lane Riverside Car Park,
Surrey, KT12 1QW (ish)
Google Maps Link...
The summer is so darn close now so it's time to get those glorious old cars out, get them polished up and get them down to the Walton Bridge Breakfast Club...
The WBBC is here again and it needs YOU to make it as interesting and as varied as it has always been!
Each and every meet just keeps getting better so please do come along and get involved with your car or just come along and have a peek to see what the WBBC is all about! Without you lot this meet would be nothing so thanks ever so much to you all, you make this meet what it is and I really cannot ask for more than that can I...?!
So, what's what...?!
Walton Bridge Breakfast Club is back and I want all you wonderful people to come down in your equally wonderful old/unique/special/rusty motors...! You really do need to come along if you're into old/classic/retro/exotic/unique vehicles as I think this really is the meet for you...
Come along to the beautiful riverside in Walton-on-Thames for some good old fried grub (I'm not the healthy eating kind of chap but I can bring a box of Muesli along if anyone wants some!!!), a mug of hot coffee and a chance to have a gander at a superb and varied selection of wonderful classic and exotic vehicles of all types...
This is just a little, local meet so all makes and types of classic and distinctly unique vehicle are more than welcome to attend and that is what I encourage... Variation is the key here so please don't be shy (don't ever underestimate what you've got)! Cars, trucks, tractors, buses, motorbikes and boats (we are right by the river!!!) are all welcome if that's what you've got!!!
Please be aware that although the car park is pretty large other members of the public will be using it also so it is all based on a first come, first gets a decent space rule (things do get very busy!)... This is why I've started the meet from 08:00hrs!
Please drive carefully and responsibly in the car park as other people will be carelessly wandering around in there...!!! Safety is paramount so caution is the key... Keep your eyes peeled for people on foot as they won't keep their eyes peeled for you...!!! I cannot stress the importance of being sensible in the car park enough...
Bring your vehicle, bring your family, bring your friends and don't forget to bring a fully charged camera...
So, please do spread the word far and wide and let everyone know about this meet as I want this to be yet another ruddy good one... The Walton Bridge Breakfast Club is here and it's here for people just like you and I!
See you all there (I hope!)...
For more info' please email me on email@example.com
http://www.facebook.com/waltonbridgebreakfastclub" onclick="window.open(this.href);return false;
* Future WBBC meets for 2016 TBC...
Walton Bridge Breakfast Club - Surrey - Sunday 05/06/2016
Bike shows, road runs, any bike related events-post here
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Today sees the launch of a brand new community history website for Portsmouth, A Tale of One City – rather wittily named to coincide with the bicentenary of Charles Dickens. Click the link below to take a look:
It's a great way to not only find out about people, places, topics and facts about Portsmouth, but it is also very much YOUR website – you can contribute your own stories and your own pictures. This is something I'm really excited about – there has been a lot written about the history of Portsmouth, but this is a great opportunity for the people of Portsmouth themselves to write THEIR history, from their perspective. There's also a forum to get involved with too.
See you there!


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U.S. Equal Employment
Opportunity Commission
Automotive Supplier Settles Bias Case Despite Bankruptcy
DETROIT -- Noble Metal Processing, Inc., a Warren, Mich., automotive supplier, has agreed to pay $190,000 to settle a race discrimination and retaliation lawsuit brought by the U.S. Equal Employment Opportunity Commission (EEOC), the agency announced today.
According to the EEOC's suit (Case No.2:08-CV-14713), filed in U.S. District Court for the Eastern District of Michigan, Noble repeatedly overlooked qualified non-white employees, including a group of black employees and a Bangladeshi employee, for promotions to the maintenance department. In addition, a white employee who opposed this type of race discrimination and complained that managers in the maintenance department were using racial slurs was fired shortly after the company learned of his complaints.
Race discrimination and retaliation violate Title VII of the Civil Rights Act of 1964. The EEOC filed suit after first attempting to reach a voluntary settlement out of court through its conciliation process. After the EEOC's lawsuit was filed, Noble, a wholly owned subsidiary of Noble International, filed for bankruptcy and closed the plant where these employees worked. Despite its bankruptcy, Noble made efforts to resolve this case.
"Noble should be commended for reaching a resolution despite its financial difficulties," said Nedra Campbell, an EEOC attorney in the Commission's Detroit office. Under the parties' agreement, seven employees will share in the lump sum settlement amount of $190,000.
The EEOC enforces federal laws prohibiting employment discrimination, including race discrimination. Further information about the EEOC is available on its web site at www.eeoc.gov.


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2zero6 wrote:wildcatter wrote:2zero6 wrote:Man, then all the naysayers might have to buy a 450 just to be able to keep shooting you can only reload brass so many times, ha. Nice to have a manufacturer like Hornady backing our shooting needs.
Hey! Not just Hornady are you aware that Remington is Offering a 250gr Cor-loc loading And there are some even bigger things about to be announced that will knock your socks off. The 450b is just getting started and it's future is way going into the stratosphere, you'll see it soon enough, then you'll Really-Really know you made the right decision (as if you didn't already know this)..


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Griner The Great still in her prime
WACO — As she maneuvers her longboard across campus, Brittney Griner occasionally bumps into prospective students or parents visiting Baylor University.
Frequently, she's a tour stop in her own right.
"I'll skate by, and the (tour guide) will say, 'And there goes Brittney Griner on her longboard. Heeyyyyyy, Brittney,'" Griner said. "And I'm, like, 'Heeyyyyyy.'"
And with a word and a wave, she's off: college basketball's reigning women's player of the year, who in less than four years has become a 6-foot-8 campus landmark to rival Pat Neff Hall, Burleson Quadrangle and Armstrong-Browning Library.
Griner, however, is a portable treasure. Sunday's NCAA tournament game against Prairie View A&M and, presumably, Tuesday's meeting with Florida State or Princeton will be her final home appearances in a Baylor uniform.
From there, the Lady Bears expect to advance to the NCAA regional in Oklahoma City and, in two weeks, the Final Four in New Orleans, where Baylor is favored to win a second consecutive national title.
Then, for Griner, it's off to the WNBA, where some think she has the potential to affect the women's pro game in the same way Wilt Chamberlain transformed the men's game in the early 1960s.
She will be remembered at Baylor, and across women's college basketball, as The Great Brittney Griner: a heavy burden to carry at age 22, even when you can score virtually at will and block shots at a rate unprecedented in the history of NCAA basketball.
And so the question presents itself on this first Sunday of March Madness: How great is the Great Brittney Griner?
Griner smiles and shakes her head at the notion.
"I feel like the Great Oz," she said. "I'm so young in my career and in age. So for them to say 'The Great' in front of my name, it's like something you would see at the end of a career. It's strange that they're saying it right now.
"I'm in the beginning stages of becoming great. I'm still so young at it. I haven't played pro ball. I need to go through every stage before I can be labeled as great."
Others, however, are more forthcoming on her behalf.
"I've never seen a more dominant player," said ESPN analyst Rebecca Lobo, the former All-American at Connecticut and WNBA star for the New York Liberty. "We have never seen a player with this kind of body or this kind of athletic ability, and I don't know that we ever will."
Added Nancy Lieberman, who as "Lady Magic" was the first and inarguably still one of the greatest of the post-Title IX stars of women's college and professional basketball: "She doesn't just play the game. She has changed with the game. She is in the category with the Cheryl Millers, the Ann Meyers, the Diana Taurasis."
"I've said it many times: I've run out of adjectives to describe Brittney Griner," said Kim Mulkey, who played for a dynasty at Louisiana Tech and who as Baylor's coach has led teams including Griner to a record of 133-14 entering Sunday's game.
Griner's list of accomplishments surpasses her 88-inch wingspan: twice All-America, with one on the way; three-time Big 12 MVP; four-time Big 12 defensive player of the year; consensus 2011-12 player of the year. She has 3,203 points, second-highest in NCAA women's history, with 736 blocked shots, the highest total for a male or female player since the NCAA has tracked the statistic, and 1,263 rebounds.
And then there's the impact that numbers can't measure: When the Lady Bears come to town, she's a rock star.
"It's not just Baylor people that love her," Mulkey said. "It's everywhere we go. Whether it's to Dallas for the Big 12 tournament or the NCAA tournament, she wants to walk the streets with her teammates and go out and be normal, but she can't. She has to have (security) with her."
Griner's only answer and defense is to keep moving — quickly — and keep winning.
At Baylor, she's done a lot of that. She created immediate buzz after her standout career at Aldine Nimitz with her ability to dunk, and unfortunately, one brief moment of misplaced emotion: She was suspended for the final two games of her 2009-10 freshman season when she punched Texas Tech forward Jordan Barncastle, who had fouled Griner with an elbow, and broke Barncastle's nose.
She returned and led the Lady Bears to the Final Four, where they lost in the semifinals to eventual champion Connecticut. A year later, Baylor lost its regional final to Texas A&M, which went on to win the title.
In her junior year, the Bears won the NCAA title with an unprecedented 40-0 record. Griner was a candidate for the 2012 U.S. Olympic team but opted out, citing summer school and a family illness, then she broke her wrist while riding her beloved longboard last May. The injury healed by fall practice, and Griner has not missed a beat, averaging 23.6 points, nine rebounds and 4.2 blocked shots.
For all her individual accomplishments, one of the elements that may lift Griner into such rare air is the chance to make it to a third Final Four with a second national title, which Mulkey believes says as much about her teammates as about Griner herself.
"She can't win it by herself," Mulkey said. "If our players don't throw it to her, how many points can she score? She makes those around her better. But everybody has a role to play."
Those roles are considerably easier, though, with Griner on the floor, said senior Destiny Williams, who along with guard Jordan Madden has been a key element to Baylor's success during the Griner era.
"She has made my basketball career in college easy," Williams said. "She's going to be the best female player to come out of college."
As Baylor prepares to defend its title, Mulkey hearkens back to the description of a familiar opponent, Connecticut coach Geno Auriemma, to summarize Griner's impact on the NCAA tournament.
"When he had Diana Taurasi (who led the Huskies to three straight titles in 2001-03), I won't forget Geno saying, 'I have Diana, and you don't,'" Mulkey said. "That was a strong statement on his part.
"So while it's not creative on my part, the best way I can say it is that we have Brittney, and you don't. I don't know any other way to put it." firstname.lastname@example.com


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Faith and Works
Some years ago, I read an article in which the author argued rather vigorously against the teaching that believers are justified by grace alone through faith alone on account of the work of Christ alone. According to this author, the …Read More
Faith Alone
In 1647, a group of Reformed pastors and theologians meeting at Westminster Abbey in London completed a set of documents we now know as the Westminster Standards, which include the Confession of Faith and the Larger and Shorter Catechisms. The …Read More
Caring for Our Families
A few years ago I wrote a short book on justification that was published by Crossway under the title Counted Righteous in Christ. In one section of it I ask, "Why would a pressured pastor with a family to care …Read More
Justified by His Blood
Have you ever wondered why God loves you and desires you in His eternal blessed presence? Have you ever contemplated (seriously) why God would look favorably on you and bless you rather than condemn you? Most of us (dare I …Read More
Justification by Death?
In the sixteenth century, Christendom underwent one of the most extensive and serious schisms in its history. The chief article that caused the controversy to end in division was the doctrine of justification by faith alone. The Protestant Reformation was …Read More
Making Molehills Out of Mountains
The crisis regarding the doctrine of justification that provoked the Protestant Reformation in the sixteenth century has not yet been resolved. Thus, the Reformation is by no means over. The dispute over justification that split the church back then threatens …Read More
Why Is Justification So Important?
During the Protestant Reformation of the sixteenth century, there were few things more precious to believers than the recovery of the biblical doctrine of justification by faith alone in Christ alone. Centuries of semi-Pelagian (and Pelagian) growth were dragged into …Read More
A Message Worth Fighting For
Paul's letter to the Galatians is relentless in its insistence that there is only one, true gospel. Any subtraction from or addition to the saving message of God's work in Jesus Christ renders the gospel impotent. That is why Paul …Read More
Basking in the Benefits
Q. What are the benefits which in this life do accompany or flow from justification, adoption, and sanctification? A. The benefits which in this life do accompany or flow from justification, adoption, and sanctification, are, assurance of God's love …Read More
The True Sons
Who are the true sons of George Washington? Every player in our political arena today attempts to legitimize his or her political agenda by an appeal to the Founding Fathers. American politicians must be able to show that they embody the …Read More
When Wright Is Wrong
If you are a reader of contemporary theological works and you have not already encountered the name "N.T. Wright," you will. Wright is the Anglican Bishop of Durham, and he is one of the most prolific biblical scholars of …Read More
Christian Loses His Burden
As a seminary student, I remember my favorite professor often setting forth arguments for particular theological positions. On many occasions, as these debates proceeded, the professor stopped in mid-sentence, paused, looked at his students and said, "I sense that you …Read More
Necessary Qualifications
When in the course of human language it becomes necessary to qualify the meanings of words, we must unite and defend the correct use of our language against the onslaught of misused phrases, misappropriated adjectives, and misunderstood words. In the …Read More
Justification by Association
Over the past few years I have grown increasingly concerned about the state of evangelicalism. There has been a rapid decline of doctrinal integrity, and evangelical churches throughout the country have lost their theological bearings, especially regarding the doctrine of …Read More
Justified by Faith, Perfected by Hope
The great Apostle who so clearly teaches us the liberating gospel truth that sinners are justified by faith, later in the same epistle adds that "we are saved by hope" (Rom. 8: 24). While Romans chapters 3 through 5 teach …Read More


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Street closures for AIDS Walk, Marine Corps Marathon, and Howard University Homecoming Parade | News
Title (Max 100 Characters)
WASHINGTON (WUSA9) -- D.C. authorities have released a list of street closures for some events this weekend. On Saturday, the 2013 AIDS Walk and the Howard University Homecoming Parade will take place in the District. The Marine Corps Marathon happens on Sunday.
The staging area will be on Pennsylvania Avenue, NW from 13th Street to 14th Street, NW. The following streets will be closed from 7:00 p.m. on Friday until 2:00 p.m. on Saturday:
• 14th Street, NW and Pennsylvania Avenue, NW
• 13th Street, NW and Pennsylvania Avenue, NW
• 13-1/2th Street, NW and Pennsylvania Ave, NW
Race Route
The race start time will be from 8:30 a.m. to 11:00 a.m. at which time the roadways mentioned below will be closed to traffic:
• Route will begin and end at 12th Street, NW and Pennsylvania Avenue, NW
• East on Pennsylvania Avenue, NW towards 3rd Street, NW
• South on 3rd Street, NW to D Street, SW
• West on D Street, SW to 4th Street, SW
• North on 4th Street, SW to Independence Avenue, SW
• West on Independence Avenue, SW to 7th Street, SW (turn around)
• East on Independence Avenue, SW to 3rd Street, SW
• North on 3rd Street, SW to Pennsylvania Avenue, NW
• West on Pennsylvania Avenue, NW to the finish line
For more information go to: http://www.aidswalkwashington.org
The staging area time will be at 7:00 am in front of the Johnson Administration Building (2400 6th Street, NW) on the Howard University campus.
Parade Route
The parade start time will be at 10:00 am until approximately 12:30 pm at which time the roadways mentioned below will re-open to traffic:
• North on 6th Street, NW to Fairmont Street, NW
• West on Fairmont Street, NW to Georgia Avenue, NW
• South on Georgia Avenue, NW to Florida Avenue, NW
• Southeast on Florida Avenue, NW to 5th Street, NW
• North on 5th Street, NW to T Street, NW
• East on T Street, NW to Anna Cooper Circle, NW
• Southeast around the circle to 3rd Street, NW
• North on 3rd Street, NW to Elm Street, NW
• East on Elm Street, NW to 2nd Street, NW
• North on 2nd Street, NW to Bryant Street, NW
• West on Bryant Street, NW to 4th Street, NW
• North on 4th Street, NW to the Valley (between College Street, NW and Howard Place, NW where parade will disband)
This event is scheduled for Sunday, October 27, 2013. The race begins at 8:00 am in Arlington, Virginia, and then crosses the Potomac River into the District of Columbia. The following streets along the race route will be closed beginning at 6:50 am and are expected to reopen by 1:30 pm:
• Francis Scott Key Bridge
• Canal Road, NW - from M Street, NW to Reservoir Road, NW
• Reservoir Road, NW -from MacArthur Boulevard, NW to Canal Road, NW
• MacArthur Boulevard, NW -from Foxhall Road, NW to Reservoir Road, NW
• Foxhall Road, NW - from Canal Road, NW to MacArthur Boulevard, NW
• M Street, NW - from Canal Road, NW to Wisconsin Avenue, NW
• Wisconsin Avenue, NW - from M Street, NW to K Street, NW
• K Street, NW - from Wisconsin Avenue, NW to Rock Creek and Potomac Parkway
• Rock Creek and Potomac Parkway, NW - from K Street, NW to Independence Avenue, SW
• Memorial Bridge
• West Potomac Park
• East Potomac Park (access to Golf Course and Tennis Courts available)
• Maine Avenue, SW - from East Basin Drive, SW to Independence Avenue, SW
• Independence Avenue, SW - from Maine Avenue, SW to Ohio Drive, SW
• Ohio Drive, SW -between independence Avenue, SW and Lincoln Circle, SW
• Lincoln Circle, SW - from Ohio Drive, SW to Henry Bacon Drive, NW
• 23rd Street, NW -from Lincoln Circle, NW to Constitution Avenue, NW
• Constitution Avenue, NW - from Bacon Drive, NW to 15th Street, NW
• 15th Street - from Constitution Avenue, NW to Independence Avenue, SW
• 17th Street - from Constitution Avenue, NW to Independence Avenue, SW
• Madison Drive, NW - from 15th Street, NW to 3rd Street, NW 3rd Street, NW - from Pennsylvania Avenue, NW to Independence, SW
• Pennsylvania Avenue, NW - from 3rd Street, NW to East Capitol Circle, NW
• 1st Street - Pennsylvania Avenue, NW to Maryland Avenue, SW
• Maryland Avenue, SW - from South Capitol Circle, SW to 3rd Street, SW
• Jefferson Drive, SW - from 3rd Street, SW to 15th Street, SW
• 14th Street, SW - from Jefferson Drive, SW to Northbound HOV lanes
• HOV lanes - from 14th Street, SW to HOV ramp at South Eads Street, NW
**Westbound M Street will remain open up to Wisconsin Ave NW. Motorists will be forced to turn north on Wisconsin Avenue NW from M Street NW or east from Wisconsin Avenue NW to M Street NW. Westbound M Street NW will remain open unless otherwise determined. A course map as well as additional information regarding street closures in Arlington County is posted at www.marinemarathon.com.
Police will reopen the roadways as soon as possible, as long as it does not interfere with the race. Metrorail will begin service at 5:00 a.m. on Sunday. Race participants and spectators are encouraged to use public transportation.


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The program Mental Distress / Fear is designed for people suffering from mental distress • anxiety • fear and all kinds of psychological problems related to stress.
A Digital Studio Recording Under the Artistic, Scientific and Technical Direction of the Composer and Musicologist.
Gesamtspielzeit: 72 Min.
Medical Resonance Therapy Music®
RRR 951 Mental Distress / Fear
|1 Compact Disc
|23.40 €
|1 Download in CD Quality
(16 Bit, 44.1 KHz, wav-format, filesize 736.0 MByte)
|16.30 €
"Best Scientific Preparation Against STRESS"
|WHO World Health Organization
as acknowledged on the conference of the World Health Organization "Society, Stress & Health" at the Academy of Sciences in Moscow
Directly from the producer: the only quality guarantee you can have
therefore: directly from the composer: no black market.
more titles from this program
– please click on an image to load the title –
|Complete Mental Distress / Fear Program · 12 CDs
|Advanced Mental Distress / Fear Program · 8 CDs
|Basis Mental Distress / Fear Program · 4 CDs
|RRR 951 Mental Distress / Fear
the creator of Medical Resonance Therapy Music® has determined, that anyone who needs the help of the harmony laws of nature, or the Medical Resonance Therapy Music®, should get it:
On request of Peter Hübner everything around his Music is organized in such a way that no one from the side of producing the music draws personal profit from it.
It is done via the INTERNATIONAL PHILHARMONY and applies just as much to the composer himself as to anyone else: all profits from the sales of his works are used for further research and development in the fields of music, medicine and education and in the materially not so wealthy countries also for providing patients, children, pupils and students with Medical Resonance Therapy Music® and if necessary also with audio equipment for listening to it.
A music example in mp3 format can unfortunately only give you a small insight into the musical work.
Due to the variety and depth of the musical work we recommend a better version - CD format in 16 bit or even better: the 24 bit version.


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Free Entry
The Lapunyah Art Gallery is a volunteer-run gallery presenting touring exhibitions and artworks from local and visiting artists. Entry is free to all. Activities at the gallery include up to 20 exhibitions per year, official exhibition previews, Artist's Walks, guided tours for community groups and schools, arts and crafts workshops for children and artists, two gallery spaces, arts and crafts for sale, and information sharing about the arts in the local community.
The Gallery holds an annual visual arts competition in February. Please visit the Lapunyah Art Gallery Facebook page for details of current exhibitions and events.