text:
I've never met a closet capable of containing all my clothes. Doors have never shut; drawers never closed. In my bedroom, I've always kept a large chair buried under clothes. One boyfriend generously likened it to a modern-art installation. Some saw it differently. One guy walked into my bedroom for the first time and exclaimed, "Oh my god, you've been robbed!"
When you live in chaos, you attract more chaos. And in college, chaos was fun—crazy nights out, can-you-believe-what-happened days. But a few years ago, when I landed my dream job and everything else in my life seemed to fit into place, my mess stopped being a funny quirk and began to be my secret shame. I no longer had time to rummage around for a missing shoe. I felt like my mother, exasperated by a pile of coats on the floor. And I was mad at myself—I had mastered so many difficult things and yet I genuinely sucked at hanging up my clothes. It was time for my closet to grow up.Before the clean-out.
I had heard of companies that trick out basic closets into Pinterest-worthy feats of organization. I had dismissed it as the kind of thing annoying, OCD people did. In reality, I was overwhelmed, kind of cheap, and embarrassed. But I had hit a wall, fighting with my stuff in the mornings, losing things in my own home. I called Carolyn Musher, a design consultant for California Closets. And the first thing she said, to my relief was "It's not your fault."
Like many city dwellers, I suffered from a lack of closet space. I only had two closets for everything I owned. Carolyn designed a wardrobe that would replace my chair "storage unit" and my overstuffed dresser. Designing a system with her on her laptop gave me a giddy sense of control. But once my new closet was built a couple of weeks later, I found I didn't know how to use it.
Laura Cattano, pro organizer, helped me take my new physical space to the next level...and create the mental space I needed to push through my big cleanup. For the price of a pair of shoes, she space-whispers your place. "People use their closets to hide things," she says. "I help people see what they actually have."
For hours one Sunday, we turned my closet inside out. Saying good-bye to your stuff can feel strangely emotional, because in fact, you're letting go of pieces of yourself, the belongings that once defined you. You have to acknowledge that you're not in college anymore (whoa—I know!) and how you live is completely up to you. And the sheer volume of mess that you stir up is dizzying. At one point, I was so overwhelmed that Laura suggested I take a walk around the block.
So yes, now I have lovely closets. But I'm still me. Sometimes after a long day, stepping out of my clothes and leaving them in a heap feels like the right thing to do. But if chaos is contagious, so is order. Cleaning out your closet might feel like a small act, but it's the first step to opening doors to the new. Just see what else falls into place.Hook Up
You can never have too many hooks! I've been using these to hang scarves, guests' coats, even outfits I've planned if I have a special event or big day.
Let There Be Light
Things get lost in the dark. Small lamps cast a warm dressing-room glow to my new Sex and the City accessories nook.
Save Space
Adding a second rod across your closet and using huggable hangers will more than double your usable space.
Section Your Drawers
Snag dividers at The Container Store to compartmentalize your drawers.
Get Your Shoes Off the Floor
A bright, inexpensive rug is an unexpected but perfect finishing touch.
Shop Your Closet
Get excited to get dressed! Create storage that looks like it could be a store display.
Group Like With Like
Designate bins to contain beachy items, ski stuff, and keepsakes.
Color Coordinate
A quick way to feel pulled together is to stack sweaters, tees, towels, and linens by color. It looks so polished and chic!
The Crown Jewel
For me, it's not the jewelry itself--it's my jewelry drawer! Looking at it makes me happy.Get Motivated
1. It Will Save Your Time
Getting dressed in the morning is so much faster when you can actually see your clothes.
2. You Can Make Money!
Sell your stuff on sites like Dresm.com, Threadflip.com, and Vaunte.com. With all your extra space, you can shop for "new" items on the sites as well.
3. You'll Help Someone Else.
Donate your old linens to the local vet instead of tossing. For old clothes, click on DonationTown.com to arrange for a pick-up from a local organization.
Want more from Joyce? Follow her on Twitter @joycemarg.


text: Its been a long time since I stopped by the forum. I was was cruising my youtube subscriptions and this video popped up in my feed. Jay Leno owns truck #1 and hes going to be auctioning it off for charity. Though you guys would like it. Check it out.

subset: commoncrawl


text:
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Reference: 36395_Rugby
Apartment: 2 beds, 2 baths, 1 reception
The Cloister
A bright and spacious two bedroom apartment situated in Gray's Inn. This property comprises of two double bedrooms, two bathrooms (one en-suite), reception room and fully fitted kitchen. For further information please contact us. LOCAL AMENITIES:This property is located close to the amenities of Holborn, featuring a range of bars, restaurants and shops. LOCAL TRANSPORT LINKS:Nearby underground stations are Holborn (Piccadilly and Central lines), Chancery Lane (Central line) and Russell Square (Piccadilly line).
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text:
Ronald Dunn went to war at 18. Drafted from Bonavista, Dunn was a Gunner in the Royal Newfoundland Regiment. He survived the battle of Beaumont Hamel while others fell around him.
Remembrance Day is a time to remember and understand what went on in the World Wars, and why this destruction and devastation had to take place. Many Newfoundlanders were lost or crippled as a result of war.
The people who really remember are the veterans. No matter how many years have passed, the reality of war burns fiercely in their minds. The scars will never disappear.
Respect and a high degree of understanding is the most that can be expected from the young. What youth need to realize is that those marching souls of a forgotten war were also young at one time. To them, youth was precious, as it is now, but the difference is that in their time, youth was expendable.
Today is the day that we should honour those who served, those who gave their all for freedom; men such as Ronald Dunn of Bonavista. Dunn was living history of one of the bloodiest battles the world has ever known.
Drafted when he was 18 years old, Dunn served in "D" company of the famed Royal Newfoundland Regiment of the 29th division.
The Newfoundland Regiment was involved in a number of battles during the First World War and again and again proved their courage and ability, so as to earn them the title of 'Royal'.
Dunn was a Lewis Gunner in the Royal Newfoundland Regiment. A Lewis gun could fire rapidly and take out a large number of men in a very short time. Dunn toted the gun as he took part in one of the bloodiest and most devastating battle the world has ever known.
The day was July 1, 1916 and the place was the valley of the River Somme in Northern France. The Newfoundland Regiment was involved in the battle of Beaumont Hamel. A name that will forever linger in the hearts of Newfoundlanders.
For many years after the war, as it was with many veterans, Dunn would not talk much about his experience. Now it seems he's able to talk about it more freely. Dunn recalls first when the Newfoundland Regiment was sent to the Dardanelles to take part in the Gallipoli operation at Sulva Bay he had his first experience with the misery of trench warfare.
"We had a hard time, no question about it. You had to be iron to stand it."
In the trenches were millions of black flies and crawlers swarming over the bodies. There was very little to eat. Towards the latter part of November the rain came and filled the trenches. Following this fell the snow and came the freezing temperatures.
"You could walk on the ice in the trenches said Dunn. A lot of our boys got their hands and legs frozen. Our clothes were wet you see."
The men suffered from dysentery, diarrhea and lice. Some men died while others had to be taken from service to recuperate. These are the things the men had to face, besides fighting the Turks. Dunn recalls putting jam on a biscuit. "Before you got it to your mouth it would be black with flies. You'd have to eat it. There wasn't much you could do.
"Movement in the trenches had to be made with caution for fear of Turk snipers. They were a crack shot. One fellow," recalls Dunn, "Raised his helmet on his rifle, and there was a bullet shot right through the crown of it. Our fellows, many of them were a crack shot too, that's the way it was on both sides."
Even at night the men had to be alert because the darkness gave the snipers a chance to move around.
"We were out of the trenches one night and one of our boys got hit. I was pulling him in when I saw two men crawling towards us. I thought they were a couple of our boys at first. They were Turks. One of them said to me, 'wounded mate?' and I said 'yes.' 'Okay, go ahead,' he said… They could have killed both of us."
After evacuation of the Gallipoli operation, the 29th division were assigned to France. In the early hours of July 1, 1916, Dunn was preparing to attack the German front line near Beaumont Hamel. The 29th division, which contained three brigades, of which the 88th contained the Newfoundland Regiment, was part of a major offensive by the British Empire. That morning, nearly 100,000 British troops left their trenches and at day's end, their casualties were 57,470, nearly half of the troops engaged, including almost 20,000 killed. That day, no regiment suffered more than the Newfoundland Regiment.
Slowly and solemnly, Dunn reveals his story as happened on that bloody day in 1916.
"We waited and waited for the time to come. I got to say, we had a fine bunch of boys. Anyway, the time came to go over the top. There were seven of us who carried Lewis guns and one was shot in the head as we left the trench."
The men coming out of the trenches that morning faced the Germans who were well prepared for the attack. Advancing troops were simply mowed down by the German machine guns.
"The six of us went on and one by one we began to drop until there was only me and another fellow. We went on, and he got killed. I didn't go far from where he was killed until I got it. I got two bullets in the leg. One went right through and the other smashed the bone and went out the same hole, on the back of my leg, as the first went out. There were two holes on the front of my leg and one on the back. I lay down, and when I looked there was a shell hole there. It was a bit deep. So I got in that one and my legs were up, but my head and body were down."
Wounded and dead lay everywhere and were so dense they hindered the movement of the soldiers still advancing. But with the walls of hot lead and bullets coming at them, the Newfoundlanders advanced, steadily, dropping left and right, until they could advance no further. Inside 20 minutes or so, the Newfoundland Regiment had been wiped out.
"The blood was coming out of my leg. The holes in my leg were big; I could put my finger in them. We carried a bandage with us but it was only good for one bullet. I stayed there in that little hole. The sun was pouring down and the shells flying made it even hotter. I made up my mind that I'd crawl in when it got dark.
While lying in the hole, Dunn could not move, for the slightest movement caught the eye of some German gunner.
"I moved around a bit a couple of times, and they saw me. They fired and the bullets came pretty close to my head."
Even while bullets passed directly over his head, the spirit of this man remained high. His thoughts were for his fellow men who lay all over the ground near him.
"I bawled at the men on the ground because if the Germans saw me moved in the hole then they would see them for sure. Anyway, I knew then it was no good."
It seems impossible that anyone could stand in the overpowering German gunfire for long. The Newfoundland soldiers carried 60 or more pounds of gear and had to maneuver through selected gaps in their own wire, and then on across a thousand yards of what was known as 'No Man's Land', then to the German wire and trenches; open all the time to the blistering German gunfire. Few men made it that far.
When darkness came that night, Dunn got to his knees and tried to crawl in.
"There was wire whichever way I went. I tore my chest and my back trying to get through, so I went back and got into the hole and stayed there all Saturday night. Sunday morning came and I was feeling sick. A piece of shell came and struck me in the chest. It bounced off and I put my hand on it. It was warm. If it was hot, it would have went through my chest. It didn't hurt me."
Dunn stayed in the hole while his mouth cracked for lack of water. He admitted he felt as if he wasn't going to make it.
"I felt I would see home no more. I was there all day and when the sun went down, I went down too."
He knew no more, only bits and pieces, until he awoke in the hospital days later.
Among the ranks, he was listed as missing at first, later as wounded.
The Newfoundland Regiment had gone into action 801 strong. When the role call was taken the next day, only 68 answered their names. The final figures of the battalion were: 233 killed or died of wounds, 386 wounded, and 91 missing.
While Dunn was in hospital in Bristol, England, King George V visited and issued a letter of get well wishes, and of thanks for faithful service to all wounded soldiers there. Being the only Newfoundlander at the hospital, at that time, Dunn figures he is the only Newfoundlander with such a note.
After being discharged from the hospital, still with a painfully crippled leg, Dunn was sent home. Back in Newfoundland he attended school in St. John's for nine months, then took a job with the Customs Department.
Times were hard and after being home a short while Dunn noticed a friend without proper pants to wear. Dunn took the pants from his uniform, one of his most precious items, and gave it to the friend.
This man of courage and bravery, who survived the hot steel and lead of the enemy, and who fired back to kill the enemy in the line of his duty, really has a heart of gold when it comes to his fellow man. Why then, did men like this have to try and tear each other apart in war?
The battle of Somme was a disaster felt in every home in Newfoundland. Many say Beaumont Hamel need not have happened. The bravery, dedication and courage of these Newfoundlanders to face an impossible situation, almost certain death, and still advance until they could no more is a true tribute to Newfoundland and the Royal Newfoundland Regiment; for those men gave all for their freedom.
Research into Dunn's World War years has been a rewarding and educational experience. It was indeed a honour and privilege to have an opportunity to talk with and write about such an admirable man. It has been an unforgettable experience.
One cannot totally comprehend in this day and age, what men or boys at the time, like Dunn went through; what war was really about. But these men and what they did should always be remembered and respected.


text:
South Dakota State's John Stiegelmeier on North Dakota State Loss, Southern Illinois Match-up
It's been a tough two-week stretch for the South Dakota State football team.
The Jackrabbits closed out the non-conference part of their schedule two weeks ago at Nebraska and gave up 38 unanswered points, losing 59-20 to the Cornhuskers.
Up next was the #1 team in FCS, the two-time defending national champions, North Dakota State, and SDSU never found the end zone against the Bison, losing 20-0.
This week, the Jacks are looking to bounce back in front of a big Hobo Day crowd, when they welcome Southern Illinois to Brookings.
The South Dakota State offense will be trying to snap a seven-quarter scoreless drought, although head coach John Stiegelmeier told me he doesn't believe the lack of points the last two weeks are an area of concern - yet:
After being held to -32 yards rushing last week against NDSU, the Jacks find themselves going against another run savvy defensive group this week in the Salukis, who are 8th in the nation in run defense and #1 in the Missouri Valley in tackles for loss, thanks in large part to linebacker Bryan Presume who had 12 tackles last week in a loss against Youngstown State:
Offensively, the Salukis are led by quarterback Kory Faulkner, who had a career game in the loss to Youngstown State last weekend, passing for 348 yards and leading SIU in rushing with 71 yards. He presents some challenges for the SDSU defense:
The weather might be a contributing factor to this weekend's storyline, with highs falling to the mid 40's, with wind, and a chance of rain. Those conditions may alter the Jacks game plan a bit:
Regardless of the weather, a big Hobo Day crowd is expected as the Jackrabbits play their 100th homecoming game, with a new look:
On the opposing sideline this week isn't just another head coach, it's Dale Lennon, a close friend of Stiegelmeier's. It's a relationship that dates back to Lennon's days in the old North Central Conference:
One thing Stiegelmeier is looking for this weekend is a strong start, something he says will show him his team has bounced back from two very trying weeks:
Kickoff at Coughlin-Alumni Stadium is 2:00pm Saturday.


text:
Battle of the Expository Bridge
|Wars of Stanley the Tool
|Stanley's Historic Battles, The Gobwin Knob Campaign, Destruction of Unaroyal, Assault on Jetstone, Faq's Homeward Blitz, The Magic War
|Assault on Jetstone
|Battle of the Expository Bridge, Siege of Spacerock
|Previous battle: Battle of Chocula
|Concurrent battle: None
|Next battle: Siege of Spacerock
|The Battle of the Expository Bridge
|Conflict: Wars of Stanley the Tool, Assault on Jetstone
|Date: 66 turns after the Battle for Gobwin Knob, 75 AW
|Place: Expository Bridge
|Outcome: RCC II victory
Other Allied Sides
After the Destruction of Unaroyal the Battle of the Expository Bridge (75 AW) is the next campaign move of Stanley the Tool in his quest for the Arkentools. Stanley has sent his forces towards Jetstone under the (supposed) command of the decrypted Prince Ansom. Jetstone's capital, Spacerock, had been exposed by the new border with Gobwin Knob after Unaroyal was destroyed making it his next logical target given Stanley's history with Jetstone and the Royal Crown Coalition. However, Jetstone was prepared for the coming battle (though quietly nervous about their chances), massing its forces at the nearest choke-point, a bridge Stanley's forces must cross to reach Spacerock, Expository Bridge.
Jetstone Preparation
The Jetstone king allowed the use of some of his precious casters in the battle. With caster support the Jetstone force is unarguably superior to the force that Gobwin Knob appears to have brought. (Their flying units approach grounded and veiled.)
Faq allied itself with Jetstone and brought the largest air armada it could muster in the short preparation time (3 Warlords, 26 Gwiffons, 6 Megalogwiffs (Nb: this Is stated in Erf-b2-p010 but later on it seems clear that the number is actually higher, 10 appear in Erf-b2-p016) and hired Turnamancer Vanna to Spacerock as part of the garrison to compliment the forces of Jetstone. Jetstone seemed to lack any significant air force of its own, making them dependent on Faq for protection against Dwagons.
Gobwin Knob Turn
An initial manoeuvre by Wanda and Prince Ansom to capture Prince Ossomer was successful but led to a skirmish in which Prince Ansom was injured and the Foolamancer, Jack Snipe, was incapacitated. Interrogating the executed then Decrypted Ossomer revealed information about hidden reinforcement columns prompting Wanda to lead an assault against Spacerock's garrison from the air with the intention of croaking King Slately; this would disband or convert Jetstone (since Ossomer was heir). In the meantime, Jetstone promoted Prince Tramennis to the position of Chief Warlord. Faq leader Jillian Zamussels then moved to intercept and parley with Wanda. Jillian "agreed" to leave without a fight but instead of telling Vanna to go into the Magic Kingdom as she had claimed, ordered her to cast a spell arranged by Charlie. This Caster link enhanced spell forced Gobwin Knob to immediately end turn leaving Wanda stranded in Spacerock's air space and the infantry column without any air or caster support.
Royal Crown Coalition II Turn
After the forced turn ending, Prince Sammy of Haggar captured one of Charlie's Archons (and croaked 3 others). Believing he had the upper hand, he interrogated her, but Charlie resumed Thinkagram communication and "negotiated" with him. Charlie successfully blackmailed Sammy into leading his column across Expository Bridge and softening up the Gobwin Knob column with the "main" objective of destroying Ansom. Jillian's objection to this strategy proved to be a sufficient distraction for Ansom to best Sammy in combat.
Jillian directed Haggar's forces to withdraw and took advantage of the damage caused by their assault to surgically strike Ansom and capture him using her Megalogwiff to 'absorb' him. She appeared to have sustained some casualties and significant damage to her Megalogwiffs from having her other fliers crush Ansom's pikers in order to expose him. She then withdrew with the goal of destroying several of Gobwin Knob's cities on her way back to Faq.
Captain Ford rallied the remaining Gobwin Knob infantry with the unorthodox tactic of primarily attacking only units that can harm fliers; however, Tramennis assaulted the remaining forces in the head of Gobwin Knob's column using only his heavies and a stabber/piker advance, wiping out Ford and the remaining forces. Meanwhile in the Gobwin Knob situation room, Stanley was forced to promote a new chief warlord. Parson suggested Ossomer, but Maggie cast a suggestion spell on Stanley forcing him to choose Parson Gotti for the role instead.
With all Gobwin Knob forces either captured, croaked, destroyed, or in Wanda's air group (which moved on to the Siege of Spacerock), the Battle of the Expository Bridge ended in a costly victory by the RCC II as the only forces remaining on this battlefield.
- A predictamancer (possibly Marie Lavraie) previously had predicted to Janis that there would be disarray for Gobwin Knob in this battle.
- Charlie was indirectly involved in the battle, he was directly linked to Vanna as part of the Forced End Turn Spell and was spying on Sammy before blackmailing him into actually participating in the battle. As of yet, it is not clear if Charlie was acting of his own accord or had a contract with someone. He has an "arrangement" with Faq that is different from his usual contracts (she doesn't seem to need to pay him, at least in the present, despite his ongoing assistance) which makes his motive unclear.


text:
photographs by Brittany Ambridge styling by Elaina Sullivan interior design by Sacha Dunn
—cofounder of Common Good, an eco-friendly cleaning-supply company—keeps it casual for the holidays by drawing from her natural surroundings.
Pops of festive color make for effortless holiday decor in the living room of Sacha Dunn's weekend retreat.
New and vintage furnishings mingle throughout the family's home, including a plaid blanket a friend brought back from Scotland and a side table found at a yard sale in the Catskills.
Washable slipcovers
offer a family-friendly
design solution.
The wood-burning stove heats the house during the colder months; Levine built the hearth using bricks salvaged from a friend's barn in Germantown, New York.
a simple plan
Dunn and Levine—the cofounders of Common Good, a Brooklyn-based line of eco-friendly cleaning products—aren't just concerned about the environment; they're handy, too. Dunn, a former prop stylist, can paint a beat-up chest of drawers in an hour flat, and Levine likes to frame out rooms in his spare time. To lend a sense of airiness to the cottage's petite spaces, Dunn chose a pale color scheme—primarily white, gray, and blue—and the couple set about painting walls, floors, cupboards, chairs, and sideboards. The result is a soft, soothing palette, brightened by the occasional cranberry-red accent.
family custom
The family prefers to keep holiday decorating low-key and focused on traditions, especially as their children grow older. "We have a mix of precious ornaments that we've collected over the years," Dunn explains, "including new things the kids have made." Each year, they lead a family adventure into the snowy woods to select their holiday tree—and to gather materials for making wreaths and garlands from their endless outdoor resources. "It's all part of the fun," Dunn says.
Dunn and Levine bought these Eames wire chairs at a Brooklyn stoop sale for $20 each.
Built-in cabinets hide the television, with logs for the wood-burning stove stored beneath for easy access.
room to spare
The home has two bedrooms upstairs, as well as a detached 200-square-foot cabin that was built in the 1970s. Though originally imagined as an artist's studio, it often doubles as a guesthouse; with windows on all four sides, the small space is flooded with morning light.
Open overhead space provides for functional, attractive storage.
getting in the diy spirit
How Dunn makes vintage furnishings her own.
size matters
"Our house is small, so the most important thing is to find pieces that fit," Dunn says. "We look for good shapes that we can repaint or slipcover."
stir it up
"Mix updated older stuff with new pieces of furniture," Dunn suggests. The balance keeps a home from leaning too far toward a country aesthetic.
know your resources
"The yard sales in Columbia County are great, but I also look on 1stdibs, eBay, and Craigslist for pieces I really want," says Dunn. When she does venture out to local sales, she finds that holiday weekends offer the best spoils.
The couple's children, Max and Sadie, lounge on the bed in the guest cabin.


text:
Transmitter Solutions 310LID21K 310 MHz Firefly SU7CCF31B Mini Key Chain Remote Control
This Transmitter Solutions 310LID21K mini key chain remote control will work with any Linear Delta 3 garage door or gate receiver. Programming the remote is simple just match the 8 on/off dip switches inside the unit to your existing remote or receiver.
This Linear DNT00026 compatible unit is also compatible with the following products:
Linear Delta 3 DT, DTC, DTC, DTA, and DNT00002A, as well as Moore-O-Matic and Ultra Lift Garage Door Remotes.
Compatible with the following Delta 3 receivers: DR, DR3A, DR-2, DR-4, DRA, DRA-4, DRM, DRQP, GRD, and GRD-2.
Product Features
-Activates one Delta-3 receiver
-Test/operate LED
-Key ring clip, battery, and programming manual included
-Power: 12 V battery
-Frequency: 310 MHz
-Codes: 256 (set by 8 dip switches)
-Dimensions: 2 x 1.5 x .5 inches
-One year manufacturers warranty
- Brand: Transmitter Solutions
- Product Code: 310lid21k
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text:
Kiseido Digital is the online arm of Kiseido Publishing, the world's leading publisher of English-language materials on the game of go. Our mission is to bring Kiseido's wealth of printed content to the digital world.
Kiseido Digital Books
Kiseido Digital is proud to announce a new series of go ebooks using the engaging, compelling Books You Touch ebook technology. Our books provide the "book" feel and feature "moving go boards". Our first titles are already available. Learn more.
Go World Archive
Go World Archive is all 129 issues of Go World in digital form. Volume IV (issues 109-129) is now available for purchase Issues 1-108 are available in the popular three-disk set or individual issues.
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Go Review Archive is a DVD set of all 160 issues of Go Review, the seminal English-language go magazine published between 1961 and 1977, scanned and indexed with the same attention to detail as our popular Go World Archive. In addition to its wealth of go commentary and teaching materials, GRA also offers a unique historical perspective on Japanese go in the 1960s and 1970s. Go Review Archive may be ordered online at Kunaki, an online fulfillment house that ships to any international address.
Download a sample issue (Vol. 3, No. 6 (June, 1963), 95MB)
Kiseido Digital Bookshelf
Kiseido Digital Bookshelf One contains five masterpieces from the English go literature, available both for individual download and on DVD.
Download a sample chapter now (Kato's Attack And Kill, Chapter 1, 25MB PDF)


text:
Lead through a action packed fast paced tower defense game with a story of an invasion on your homeland by a large foreign force and as a newly appointed commander do what you can to help your country fight back and defend against this enemy force which is approaching from the country side deep into the populated cities of your home land.
Only registered members can share their thoughts. So come on! Join the community today (totally free - or sign in with your social account on the right) and join in the conversation.


text:
New alert over slimming pill
SLIMMERS using one of Britain's most popular weight-loss pills were yesterday warned it could cause possible liver or kidney failure.
Dieters could be at risk of severe illness from the fat-buster which is available over the counter on the high street, according to a new study.
Alli, which blocks the absorption of fat in the gut, was hailed as a wonder drug when it became available in UK pharmacies in 2009.
The drug is a half-strength version of a prescription obesity pill called Xenical.
Studies showed that people taking Alli three times a day for 12 weeks were twice as likely to lose at least 10 per cent of their body weight. But the pill contains the drug orlistat, which some users say can bring on a host of side-effects from hepatitis to other liver problems, headaches, stomach problems, depression and fatigue.
Official figures show that orlistat accounted for 74 per cent of the 1.45 million weight-loss drugs prescribed in England in 2009, which cost £46.8million.
Orlistat is reportedly absorbed, and certainly internal organs such as the liver and kidney are exposed to this drug upon absorption
Now, new research claims that Alli inhibits a key enzyme in the body that may lead to "severe toxicity of internal organs such as the liver and kidney".
This inhibition may be irreversible and could arguably be caused even by low level use of the drug, experts say.
Professor Bingfang Yan's study, published in the journal Biochemical Pharmacology, also says the drug alters the effectiveness of medicines, and particularly limits the effects of some anticancer drugs.
However, GlaxoSmithKline, makers of Alli, strongly refute any suggestion the medicine is unsafe.
A spokesman for the pharmaceuticals giant said: "Orlistat, the active ingredient in Alli, is the most-studied weightloss medicine and since Alli became available over -the-counter more than 12 million people worldwide have used it.
"Earlier this year the European regulator reaffirmed the safety profile of orlistat following a review of the medicine and possible side-effects.
"The results of this study [by Prof Yan] in particular are based on laboratory methods in the lab, not in humans or animals, and they aren't consistent with the wealth of data from patients who have been treated with orlistat."
Prof Yan, of Rhode Island University in the US, said: "Since it has been available over -the-counter, there has been a drastic increase of toxicity among patients using the drug. It has been linked to severe liver failure, acute pancreatic failure. and acute renal failure."
He said orlistat works in the intestinal tract by preventing fat from being absorbed by the body.
He said it has long been accepted the drug remains in the intestine and is not absorbed by the body.
But Prof Yan now says: "Orlistat is reportedly absorbed, and certainly internal organs such as the liver and kidney are exposed to this drug upon absorption."
He said the study showed the drug is a potent inhibitor of carboxylesterase- 2, which is a major detoxification enzyme in the liver, kidney and gastrointestinal track.
Prof Yan said: "When the activity of this enzyme drops in those organs, toxicity increases or the efficacy of some drugs is altered."
The enzyme is capable of metabolising a wide range of medicines including aspirin and a number of anticancer drugs, whose effectiveness may be "weakened" as a result.
In September last year, the European Medicines Agency said there had been four suspected cases of "serious liver toxicity" linked to the medicine in recent years, one of which was fatal.
Although it is a small number of cases considering the 38 million dieters across Europe who have been given the pills by doctors to lose weight, the regulator said it would look at what evidence there is linking the drug to liver damage.
It would then decide whether or not the licences for medicines containing orlistat need to be changed or even revoked.
In February this year, following a review on orlistat-containing medicines, the EMA's Committee for Medicinal Products for Human Use concluded the benefit of these drugs continues to outweigh their risks in the treatment of obese or overweight patients.
The Committee recommended product information on possible very rare liver-related side-effects should be the same for all orlistat-containing medicines.


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I posted a long reply on the fent brand topic by accident last night. Shoulda probably gone here. Short version, got some watson 50 gels would like to smoke remainder before trashing. Any tips/tricks on smoking. Last time I feel like I wasted it. Plz & thanks for the help. Message me if ya preffer. Maybe you guys will see them both or I can get Chipper to move & replace. Thanks for any help
Hi all! Been checking out the post. For some goodinfo on fent patch extraction and doses etc, search4 the PDF.' injecting fentanyl -minamising the odds'.Its out if oz harm reduction. Cheers MHD. ?
Where do you find search things? I currently have 91% ISOpropyl Rubbing Alcohol
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The Mattress & Muffin Inn is located in the small town of Benton along renowned Fishing Creek and on the edge of Ricketts Glen State Park. It is readily accessible to a variety of outdoor activities, but also boasts a prime location next to the Bakery Complex housing two fine antique malls. The Inn was built in 1904 as an elegant residence and a renovation has re-captured much of the original splendor but with a modern sensibility and flair, delighting antique lovers and their friends, too!
The Inn's spacious bedrooms have been individually decorated with antique furnishings. Each room has it's own private bath and is supplied with coffee and tea-making facilities. All rooms have cable TV and wireless internet access. While the antiques filled bedrooms are traditional, the bathrooms are contemporary, with modern fixtures and clean, simple lines.


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Will 2014 be the year of software-defined storage (SDS)? Amitabh Srivastava, President of EMC's Advanced Software Division certainly thinks so. But he calls on enterprises and service providers to force clear definition of the term so that everyone is on the same page. Drew Robb takes a closer look at 10 things you need to know about software-defined storage.
Originally published on InfoStor.
Related Topics : Fujitsu, Storage Virtualization, Desktop Virtualization, Virtual Tape Library, InfiniBand
Survey findings include pain points for secondary storage, average restore times, the growth of hyperconvergence and rate of cloud adoption in enterprises. ... More >>
With today's modern solutions, enterprises should be able to transform backup and recovery from a low-level legacy IT function to a modern function delivering continuity and value to the entire business. ... More >>
The top three data dangers lurking in cloud environments and tips for how to manage data protection and backup in a SaaS-based world. ... More >>


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text: I have come upon some funny router names when searching for a WiFi signal on my iPhone and decided to screenshot a few. Post up if you have any! LOL the first guy "don't even" had no security on his WiFi network for some reason so I hopped on it a few times and after a week or so later he changes it to "DON'T EVEN!!!1" and finally added network security. I would like to say that I actually helped the guy get some security


text:
- Research
- Open Access
Boolean modeling and fault diagnosis in oxidative stress response
- Sriram Sridharan1,
- Ritwik Layek1,
- Aniruddha Datta1Email author and
- Jijayanagaram Venkatraj2
© Sridharan et al.; licensee BioMed Central Ltd. 2012
- Published: 26 October 2012
Oxidative stress is a consequence of normal and abnormal cellular metabolism and is linked to the development of human diseases. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage; conversely the failure of the oxidative stress response mechanism can induce aberrant cellular behavior leading to diseases such as neurodegenerative disorders and cancer. Thus, understanding the normal signaling present in oxidative stress response pathways and determining possible signaling alterations leading to disease could provide us with useful pointers for therapeutic purposes. Using knowledge of oxidative stress response pathways from the literature, we developed a Boolean network model whose simulated behavior is consistent with earlier experimental observations from the literature. Concatenating the oxidative stress response pathways with the PI 3-Kinase-Akt pathway, the oxidative stress is linked to the phenotype of apoptosis, once again through a Boolean network model. Furthermore, we present an approach for pinpointing possible fault locations by using temporal variations in the oxidative stress input and observing the resulting deviations in the apoptotic signature from the normally predicted pathway. Such an approach could potentially form the basis for designing more effective combination therapies against complex diseases such as cancer.
In this paper, we have developed a Boolean network model for the oxidative stress response. This model was developed based on pathway information from the current literature pertaining to oxidative stress. Where applicable, the behaviour predicted by the model is in agreement with experimental observations from the published literature. We have also linked the oxidative stress response to the phenomenon of apoptosis via the PI 3k/Akt pathway.
It is our hope that some of the additional predictions here, such as those pertaining to the oscillatory behaviour of certain genes in the presence of oxidative stress, will be experimentally validated in the near future. Of course, it should be pointed out that the theoretical procedure presented here for pinpointing fault locations in a biological network with feedback will need to be further simplified before it can be even considered for practical biological validation.
- Fault Location
- Oxidative Stress Response
- Boolean Network
- Antioxidant Gene
- Primary Input
The control of gene expression in eukaryotic organisms is achieved via multivariate interactions between different biological molecules such as proteins and DNA [1]. Consequently, in recent years, various genetic regulatory network modeling approaches such as differential equations and their discrete-time counterparts, Bayesian networks, Boolean networks (BNs) and their probabilistic generalizations, the so-called probabilistic Boolean networks (PBNs) [2] have been proposed for capturing the holistic behavior of the relevant genes. Some of these approaches such as differential equations involve finer models and require a lot of data for inference while others such as Boolean networks yield coarse models with lower data requirements for model inference. On the other hand, historically biologists have focused on experimentally establishing marginal cause-effect relationships between different pairs of genes, which when concatenated together leads to what is known as pathway information. Biological pathways are used by biologists to represent complex interactions occurring at the molecular level inside living cells [3]. Pathway diagrams describe how the biological molecules interact to achieve their biological function in the presence of appropriate stimuli [4]. At a very simple level, biological pathways represent the graphical interactions between different molecules. However, as already noted, the pathways give only a marginal picture of the regulations (up-regulation or down-regulation) of the different genes/RNAs/proteins by other genes/RNAs/proteins.
The complexity of biological signaling and the prevelance of prior information in the form of pathway knowledge demand that genetic regulatory network models consistent with pathway information be developed. Motivated by this, we developed an approach to generate Boolean network models consistent with given pathway information and applied it to studying the p53-mediated DNA damage stress response [5]. In addition, we used a signaling diagram of the MAP-Kinase pathways to predict possible location(s) of the single signaling breakdowns, based on the cancer-causing breakdown signature [6]. Moreover, we also made theoretical predictions of the efficacy of different combination therapies involving six anti-cancer drugs, which we plan to validate in the near future.
In this paper, we first develop a Boolean network model consistent with oxidative stress response pathway information from the biological literature. Thereafter this model is linked with the PI 3k/Akt pathway and the composite model is used to pinpoint the possible fault locations based on the observed deviations in the apoptotic signature over different time windows. The paper is organized as follows. Section contains a brief general description of Stress Response Pathways while Section presents a discussion specific to the case of oxidative stress. The Boolean network model for oxidative stress response is developed in Section. The role of mitochondria as the site in a cell where the oxidative stress is generated is discussed in Section. In Section, we develop an integrated network linking oxidative stress response to the phenomenon of apoptosis via the PI 3k/Akt pathways. Section presents an approach for pinpointing fault locations in the integrated network by observing the apoptotic signature in response to certain test stress input sequences. Finally, Section contains some concluding remarks.
Stress response pathways
Oxidative stress response pathways
One of the byproducts of normal metabolism is the production of a large number of free radicals. Oxidative stress is caused by the production of free radicals in quantities beyond those that can be handled by the cellular antioxidant system. Indeed, oxidative stress has been implicated in the development of many age-related diseases, including neurodegenerative ones, such as Alzheimer's and Parkinson's, and in aging itself. In addition, excess free radicals react with the nucleotides in the DNA resulting in mutations in the long run. Although there are cellular mechanisms to sense and repair the oxidative DNA damage, mutations can accumulate over a period of time and result in a major disease like cancer. In the next section, we develop a Boolean network model for oxidative stress response pathways. This network will be later utilized to analyze different failure modes that can supress apoptosis and possibly lead to cancer.
Boolean network modeling of oxidative stress response pathways
Before proceeding to the actual modeling of the specific oxidative stress response pathways, we first formally define the general terms 'pathway' and 'Boolean Network' following the detailed development in [5]. Given two genes/proteins A and B and binary values a, b ∈ {0, 1}, we define the term pathway segment to mean that if gene/protein A assumes the value a then gene/protein B transitions to b in no more than t subsequent time steps. A pathway is defined to be a sequence of pathway segments of the form .
A Boolean Network (BN), ϒ = (V, F ), on n genes is defined by a set of nodes/genes V = {x1, ..., x n }, x i ∈ {0, 1}, i = 1, ..., n, and a list F = (f1, ..., f n ), of Boolean functions, f i : {0, 1} n → {0, 1}, i = 1, ..., n [18]. The expression of each gene is quantized to two levels, and each node x i represents the state/expression of the gene i, where x i = 0 means that gene i is OFF and x i = 1 means that gene i is ON. The function f i is called the predictor function for gene i. Updating the states of all genes in ϒ is done synchronously at every time step according to their predictor functions. At time t, the network state is given by x(t) = (x1(t), x2 (t), ..., x n (t)), which is also called the gene activity profile (GAP) of the network.
From the pathways described above and using the Karnaugh-map reduction techniques, the Boolean update equations for each node of the network are deduced. Some logical reasoning has been used for determining the equations: 1) the maximum number of predictors for updating a variable is fixed to be 3; 2) Small Maf Protein is assumed to be ubiquitously expressed and the pathway given by Eqn.(10) only increases the concentration of SMP, which in conjunction with Eqn.(9), binds to ARE and down-regulates the antioxidant gene; 3) a gene being turned on implies that the corresponding protein is being produced although, in reality, this is not necessarily true; and 4) in the case of a conflict in the Karnaugh map, biological knowledge has been used to assign either a 0 or a 1. This last point is demonstrated by a specific example. For instance, in the case of ARE, the entry shown with a grey circle around it says that when both Bach 1 and Nrf 2 are upregulated and antioxidant gene is downregulated, then at the next time step antioxidant gene will be upregulated. The biological explanation for such an update is that it corresponds to the situation where, in the presence of Stress, Nrf 2 has been activated and is relocating to the nucleus while the inhibitor Bach 1 is simultaneously relocating to the cytoplasm prior to the activation of antioxidant gene at the next time step. Such intuitive reasoning has been used to model the system here. One might use a different reasoning which could lead to a different set of update equations. However, since we are concerned only about the final steady-state behavior, such reasoning can be justified as long as the overall system behavior, defined by the update equations, matches the steady-state. As an example, the final update equation for ARE is derived as follows. In the K-maps, the ones are grouped up in pairs of 2,4,8 and so on and each group should have at least one variable staying constant. So for this case there are two groups whose equations correspond to and . The final update equation for ARE is the sum of these two equations. Please refer to Additional file 1 for some additional details. Indeed, by working with different sets of update equations, we determined that all biologically plausible ones led to the same/similar attractor behavior. From the set of possible Boolean networks we chose the ones that appealed most to our biological understanding and the resulting update equations are given below:
It is clear from the preceding discussion that some kind of oscillatory behavior of the genes will be observed when the external Stress input equals 1. On the other hand, when the Stress input equals 0, the system will rest in only one state meaning that there will be no oscillation.
Time domain simulation results
Mitochondria and free radical generation
Even though it has been long recognized that increased ROS production in mitochondria leads to genetic instability and progression of cancer, there remain several unanswered questions regarding the complex signalling capacity of this organelle [27]. The DNA is highly susceptible to free radical attacks. Free radicals can break DNA strands or delete bases. These mutations can prove to be carcinogenic. It has been estimated that more than 10,000 hits of oxidative stress occur each day. So it is important to tackle these free radicals at the source of their generation, which is why the mitochondria is also a very rich source of anti-oxidants. Although cellular mechanisms can tackle this stress, damage accumulates with age. At present altered energy metabolism is considered to be an additional hall mark of cancer progression [28] and these metabolic pathways have been investigated as targets for cancer therapy. In this paper, we will specifically focus on the PI 3k/Akt pathway which is one such pathway and is described in the following section.
An integrated network for oxidative stress response and apoptosis
Classification of faults in the integrated network
In the integrated pathway diagram of Figure 11, the two genes namely Bad and Bcl 2 are instrumental in deciding the fate of the cell. The preferred status of the two genes, when oxidative stress is not being neutralized, are 1 and 0 respectively since it corresponds to the situation where the pro-apoptotic factor is turned ON and the anti-apoptotic factor is turned OFF. Although a deviation from this state may not signal that the cell is turning cancerous, there is a higher possiblity of the cell exhibiting aberrant behaviour.
Depending on the final resting status of these two genes, one may be able to characterize the degree of invasiveness of the disease especially if it is being caused by apoptosis supression. Once it has been determined that a cell is exhibiting abberant behavior, one would like to pinpoint the location of the fault/error so that the necessary therapeutic intervention(s) can be applied. Since the digital circuit model of Figure 12 uses logic gates, it should be possible to use the fault detection techniques from the Digital Logic literature [37, 38] to pinpoint the fault locations. This will be carried out in this section. An important difference between the results obtained in Layek et al. [6] for pinpointing the fault locations in the MAPKinase pathways and the results to be presented here is that the digital circuit in Figure 12 involves feedback and its behaviour is, therefore, much more complicated to analyze. However, it should be pointed out that the simpler fault pinpointing methodology presented in Layek et al. [6] is much more amenable to biological validation via appropriately designed experiments while the same cannot be said about the results to be presented here. Indeed, the results to be presented here show that the pinpointing of the fault locations is theoretically possible even in this case, although the biological feasibility of the methods required is open to question.
We note that the faults in a digital circuit are mainly of two types [37]:
Stuck-at Faults: As the name implies, this is a fault where a particular line l is stuck at a particular value α ∈ {0, 1}, denoted by line l,s-a-α (s-a-α means stuck-at-α). This means that the value at that line is always going to be α regardless of the inputs coming in. This can be thought of as something similar to a mutation in a gene, where a particular gene is either permanently turned ON or OFF.
Bridging Faults: This is the type of fault where new interconnections are introduced among elements of the network. This can be thought of as new pathways being created in the cell. This type of fault is not considered in the current paper due to the lack of biological knowledge about new pathways being introduced.
Here, it is appropriate to mention that the biological relevance of each of these two types of faults has been discussed in Layek et al. [6].
The digital circuit in Figure 12 has feedback (shown in bold lines) and is, therefore, a sequential circuit. To detect a fault in a sequential circuit we need a test sequence. Let T be a test sequence and let R(q,T) be the response of the fault-free sequential system N starting in the intial state q. Now let the faulty sequential circuit be denoted by N f where f is the fault. Let us denote by R f (q f ,T) the response of N f to T starting in the initial state q f . A test sequence T detects a fault f iff (if and only if or equivalently this condition is both necessary and sufficient) for every possible pair of initial states q and q f , the output sequences R(q,T) and R f (q f ,T) are different for some specified vector t i ∈ T. The output being observed is the status of [Bad, Bcl 2].
The purpose of this procedure is to pinpoint the possible locations for the fault f in N f , given the output sequence of Bad and Bcl 2 for the normal and faulty circuits. It is assumed that we have no knowledge about the initial status of any of the genes. Knowledge of the initial status of the internal states is important as all future computations are based on these values. The Homing sequence is an initial input sequence that brings the network to a known internal state. So, once the Homing Sequence is given to N and N f , N will come to a known internal state. Note that a similar claim cannot be made about N f as the fault f is not known apriori. For the circuit in Figure 13, a possible Homing sequence is [0 0 0 0 0 0 0 0], which brings the internal state of the system to [0 1 0]. This means that if the Stress input is zero for eight time steps, then at the end of that period, the internal state of the system becomes [0 1 0], regardless of the initial status of any of the genes in the network. A reason for choosing this Homing sequence is that it implies that no input needs to be given to the system and it evolves to the indicated internal state. In future when we are trying to validate these results experimentally this will be of immense help. If we refer back to Figure 7, we see that regardless of the initial state, within four time steps the trajectory reaches the state ('010010') where ARE = 0 and Keap 1 = 1. This is consistent with the conclusion that we are getting from the Homing sequence here with the only difference that a slightly longer sequence is required here as the state transition diagram has a higher cardinality than that in Figure 7.
Concluding remarks
In this paper, we have developed a Boolean network model for the oxidative stress response. This model was developed based on pathway information from the current literature pertaining to oxidative stress. Where applicable, the behaviour predicted by the model is in agreement with experimental observations from the published literature. It is our hope that some of the additional predictions here, such as those pertaining to the oscillatory behaviour of certain genes in the presence of oxidative stress, will be experimentally validated in the near future.
We have also linked the oxidative stress response to the phenomenon of apoptosis via the PI 3k/Akt pathway. An integrated model based on collectively considering the PI 3k/Akt pathways and the oxidative stress response pathways was developed and then used to pinpoint possible fault locations based on the Bad-Bcl 2 apoptotic signatures in response to 'test' oxidative stress inputs. The approach used to achieve this differs significantly from the earlier results in Layek et al. [6] since the Boolean network of this paper has feedback. The approaches used here and in Layek et al. [6] could potentially have a significant effect on cancer therapy in the future as pinpointing the possible fault location(s) in cancer could permit the choice of the appropriate combination of drugs (such as kinase inhibitors) for maximum therapeutic effectiveness. Of course, it should be pointed out that the theoretical procedure presented here for pinpointing fault locations in a biological network with feedback will need to be further simplified before it can be even considered for practical biological validation.
Based on "Modelling oxidative stress response pathways", by Sriram Sridharan, Ritwik Layek, Aniruddha Datta and Jijayanagaram Venkatraj which appeared in Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on. © 2011 IEEE [39].
This work was supported in part by the National Science Foundation under Grants ECCS-0701531 and and ECCS-1068628 and in part by the J. W. Runyon, Jr. '35 Professorship II Endowment Funds at Texas A & M University.
This article has been published as part of BMC Genomics Volume 13 Supplement 6, 2012: Selected articles from the IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS) 2011. The full contents of the supplement are available online at http://www.biomedcentral.com/bmcgenomics/supplements/13/S6.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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SAN FRANCISCO (MarketWatch) — Shares of 3-D printing company Stratasys Ltd. and rig operator Transocean Ltd. are likely to be active Monday.
Transocean Ltd. RIG, +0.32% late Friday said it swung to a quarterly profit, benefiting from better comparisons with the year-ago period, when it booked a large impairment charge and loss contingencies associated with the 2010 Deepwater Horizon rig explosion and oil spill. Transocean owned the rig. Get continuous coverage of the BP trial and Read more on Transocean results.
"Investors will be closely watching management's body language on a potential dividend, which has become a fascinating discussion since Carl Icahn took a 6% stake in the company with the intent of extracting a $4-a-share dividend," David Anderson, an analyst at J.P. Morgan, said in a note ahead of the release.
Stratasys Ltd. SSYS, +0.91% reported fourth-quarter profit expectations on Monday morning. The 3-D printing company said non-GAAP fourth-quarter net income swung to a profit of $16.3 million, or 40 cents a share, compared with a year-ago loss. Analysts had expected fourth-quarter earnings of 38 cents a share. David Miller, an analyst at Gabelli & Co., recently initiated coverage of Stratasys, rating it a hold even though he gave it high marks for its focus on expansion of professional 3D printing, healthcare applications, and strong operating leverage potential.
Late Friday, Warren Buffett's Berkshire Hathaway BRK.A, +0.66% BRK.B, +0.59% released its annual investment letter. Despite Berkshire's book-value rising 14.4% in 2012, Buffett called the performance "subpar," and he said he was disappointed he failed to make a major acquisition last year. Read more on Buffett's investment letter.
Casella Waste Systems Inc. CWST, -1.83% is forecast to post a loss of 16 cents a share in the third quarter. "While strategically, CWST continues to make improvements and small tuck-in acquisitions, the company continues to see challenging volume comparison due to heavier weighting in the Northeast. And, with little to no volumes from Sandy, we expect cadence on pricing and margin to be soft," Al Kaschalk, an analyst at Wedbush, said in a report.
Boyd Gaming Corp. BYD, -3.24% reported a fourth-quarter loss of $899.9 million, or $10.24 a share, from a loss of $491,000, or one cent a share, in the year-ago quarter. It faced a quarterly impairment charge of $944 million as it said it agreed to sell its Echelon site in Las Vegas for $350 million. The company was expected to report a loss of 13 cents a share in the fourth quarter. The casino operator said on Thursday that it will sell Dania Jai-Alai property in Florida to Dania Entertainment Center for $65.5 million.
Arena Pharmaceuticals Inc. ARNA, -0.69% said Monday fourth-quarter earnings swung to a loss of 10 cents a share. It was projected to post a loss of 2 cents a share in the fourth quarter. Shares of the biopharmaceutical company are down over 7% for the year.


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I received some great comments and questions based on the blog entry/video about the many new features in DB2 Cobra. One of the more interesting questions was asked "How much work or how compatible is the new DB2 with Oracle?"The answer DB2 is very compatible, so compatible in fact, that many people have migrated from Oracle to DB2 in only days.
So what are the reasons or justification for management to consider changing their database from Oracle to DB2? The top four reasons I have heard recently are:
· Oracle contract pricing continues to go up. Every time we look Oracle wants more money because we had to add CPU cores to get application performance.
· Application performance for our BI OLAP Oracle work does not respond. We always have to rewrite the SQL or create new indexes to make it work. When we tried it on DB2, their optimizer automatically rewrites the SQL avoiding the manual SQL rewrite, improving application performance and overall response time.
· DB2 disaster recovery and HADR feature is much better than any Oracle's stand-by or their fail-over solution. Now that the application is compatible with DB2 there is no reason to risk the business because of an Oracle failure.
· Saving IT budget money is paramount these days and with our Oracle database, we continue to spend money on expanding disk requirements. DB2 data compression and the new index compression provide a way to reduce disk costs, improve database performance and minimize backup and recovery while reducing disk requirements and saving money.
Converting your database from Oracle to DB2 is very easy. You can save money for your company, your IT department, and maybe your job by migrating today.
_______________________________________________________Dave Beulke is an internationally recognized DB2 consultant, DB2 training and DB2 education instructor. Dave helps his clients improve their strategic direction, dramatically improve DB2 performance and reduce their CPU demand, saving millions in their systems, databases and application areas within their mainframe, UNIX and Windows environments. Search for more of Dave Beulke's DB2 Performance blogs on DeveloperWorks and at www.davebeulke.com.


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Attorney General Lockyer Announces Settlement With Hershey and Mars Subsidiaries To Reduce Lead In Mexican Candy Popular with Children
Landmark $954,000 Settlement Also Covers Third Major Manufacturer
(LOS ANGELES) – Attorney General Bill Lockyer today announced a settlement with three major candy manufacturers that will substantially reduce the levels of lead found in "Mexican style" candies, spicy treats that are becoming increasingly popular with children, who are particularly vulnerable to brain damage and other health effects caused by exposure to lead.
"Today's settlement is a tremendous advancement in protecting our children from one of the most dangerous substances in the environment," said Lockyer. "These companies deserve credit for stepping up to comply with the law in a way that will dramatically reduce the lead levels in these candies by spurring industry-wide reforms of manufacturing practices."
Lockyer today filed the settlement jointly in Los Angeles County Superior Court with Los Angeles City Attorney Rocky Delgadillo and Alameda County District Attorney Tom Orloff.
"The implications of this settlement, which requires the makers of Mexican-style candies to stop selling lead-tainted candy, cannot be understated," said Delgadillo. "What we have accomplished through this litigation is nothing less than a fundamental shift in the way this candy is produced -- a shift that will give untold hundreds of thousands of children a chance at a better life."
"The successful resolution of this case is a testament to the cooperation and hard work by a variety of environmental law enforcement agencies, both public and private," said Orloff. "By working together on what turned out to be a very complicated investigation, prosecution and negotiation, we were successfully able to pool resources and expertise in a way that would have been virtually impossible for any one agency to achieve."
The settling companies are: Effem Mexico y Compania SNC de C.D. and Masterfoods U.S.A., both subsidiaries of Mars, Inc.; Grupo Lorena, S.A. de C.V., a subsidiary of the Hershey Company; and Dulces Vero, S.A. de C.V.
The settling candy makers were among more than two dozen manufacturers named as defendants in a 2004 lawsuit brought by the prosecutors, who alleged the companies violated Proposition 65 by failing to warn consumers about the lead in their products. Proposition 65 – the landmark environmental and public health
protection initiative enacted by voters in 1986 – requires businesses to provide clear and reasonable warnings when consumers are exposed to substances known by the state to cause cancer or reproductive harm. The 2004 lawsuit will proceed against the non-settling defendants.
The settlement requires defendants to use new manufacturing processes to substantially reduce lead in the candies and packaging materials, to conduct independent audits within six months to ensure the processes
are curbing lead contamination, and to purchase only from suppliers that wash and clean their chilies.
Lockyer's office will make public a list of companies that meet these requirements, including manufacturers who agree to join the settlement and abide by its stringent terms.
The three settling defendants will pay a combined total of $954,000. The payment includes: $100,000 in civil penalties; $379,000 to fund programs to educate consumers about issues related to lead poisoning, provide lead testing services and environmental audits for candy manufacturers, and help implement the settlement; and $475,000 for fees and costs.
Also joining the settlement were the Center for Environmental Health (CEH) and the Environmental Health Coalition (EHC). Lockyer and the two local prosecutors filed the lawsuit with CEH and EHC in 2004 after the two groups notified Lockyer they intended to file a Proposition 65 action against candy manufacturers. Before private parties can file Proposition 65 lawsuits, they must provide prosecutors 60 days notice. In that 60-day period, prosecutors can review and investigate the case. If prosecutors decide to file a lawsuit, the private parties can continue as co-plaintiffs, but cannot bring their own action.
An investigative series published by the Orange County Register in 2004 concluded that much of the contamination in Mexican-made candies result from poor manufacturing and agricultural practices, which allow lead-tainted dirt from dried chili peppers to get into the candies.
Lockyer's office, along with the California Department of Health Services, conducted extensive testing of the products and found high levels of lead in the candies targeted in the case. Levels were as high as 0.3 ppm in some chili-candy products, and as high as 1.1 ppm in some salt-based products. The amounts were well above the level that triggers the requirement to provide a Proposition 65 warning to consumers.
In addition, the plaintiffs hired an independent food processing auditor who, with cooperation from the defendants, investigated Mexican production facilities to identify the source of the lead contamination and ways to solve the problem. The auditor concluded that a nearly 10-fold reduction in lead coming from chili powder could be achieved through processing improvements, such as using washed chilies.
Lead has been listed under Proposition 65 since 1987 as a chemical that can cause reproductive harm and birth defects, and has been on the list of chemicals known to cause cancer since 1992. Exposure to lead occurs chiefly from ingestion, such as eating or putting objects into the mouth, putting young children particularly at risk. Children exposed to lead can suffer severe adverse health effects, including brain damage, kidney damage, hearing loss and impaired growth.
Lockyer said the lead-exposure reduction achieved in the candy case helps show why Congress should defeat a proposal that would undercut Proposition 65 and similar food safety laws in other states. H.R. 4167 would preempt Proposition 65's requirement to warn consumers about carcinogens and reproductive toxins in their food. In order to keep Proposition 65 and similar laws alive, California and other states would have to obtain permission from the federal government to enforce their statutes, even when federal agencies decline to act on pressing environmental health issues.


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On Thursday, Saints interim head coach Joe Vitt suggested that the league office fired a "scud" in his direction by leaking to the Associated Press the transcript of the bounty testimony of former Saints defensive coordinator Gregg Williams.
The NFL denies leaking the transcript, citing an email sent by former Commissioner Paul Tagliabue's attorney, directing the parties to keep the transcripts under wraps. The league has sent the email to PFT.
"Dear Counsel," the message states, "Mr. Tagliabue has reviewed the question regarding the release of the transcripts of the appeals hearings he conducted. He considers the transcripts to be confidential and not for public release.
"It should be noted that the transcripts contain certain information not relevant to the matters before him related to third parties who have no involvement at all in the issues here. The release of such information could be unnecessarily harmful to these third parties."
Several of the transcripts nevertheless have been released. (It's our understanding that there's not one full transcript, but a separate transcript for each witness who testified.) Both NFLPA executive director DeMaurice Smith and attorney Peter Ginsberg, who represents Saints linebacker Jonathan Vilma, have argued that the transcripts should be released.
At this point, it's not clear who leaked the transcripts. For now, all we know is that the league has denied that they supplied the documents to the AP, or to anyone else.


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East Fan 52inch Three Blade Indoor Ceiling Fan with light item EF52135D
Nickel Finish with Remote Control
General Description
The ceiling fans with lights are the perfect combination of lights and ceiling fans, also the perfect embodiment of classic and modern styles, home essential for its both decorative and practicality.
This nickel ceiling fans with size 52 inch is suitable for room space around 15~22m2, widely used as living room ceiling fans and bedroom ceiling fans etc.
It features a nickel coffee finish, plywood blades, and light fixture with white glass lampshade, relies on a silicon steel motor with triple capacitor to provide powerful, quiet circulation. It also features three fan speeds running to stay cool in the summer for your comfort. This ceiling fan and light is controlled by remote control.
Main parts included
52" Ceiling FAN, 153*15mm Motor, three wooden Blades, LED 24W, remote control
product information
Dear friends, if you are interested in ceiling fans or you have any question, please leave your information and we will try our best to service you as soon as possible.


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Dr. Jacob Moore M.D. specializes in Blade Free all Laser LASIK, minimally invasive cataract surgery, and surgery of the anterior segment of the eye. Dr Moore has performed over 10,000 procedures. Learn More >>
Dr. Jack Sahadi M.D. is the founder of Coastal Bend Eye Center, and specializes in the medical and surgical care of serious eye disease including glaucoma and surgical problems of the eyelids. Learn More >>
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Dr. Nancy Harrison O.D. specializes in specializes in medical and refractive eye care including contact lenses and routine eye care, and pediatric eye exams. Learn More >>
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Dr. Kaylyn Cummings, O.D. specializes in primary care optometry, providing comprehensive eye examinations for ages three and up.Learn More >>
Coastal Bend Eye Center has served Corpus Christi and the surrounding communities since 1977 with the goal of providing excellent comprehensive medical and surgical eye care to people in Corpus Christi. We offer routine eye exams, treatment of medical conditions of the eye and surgery for vision correction and eye problems such as diabetes, cataract, glaucoma and cornea transplantation.
Coastal Bend Eye Center understands that our patients have different visual needs. We offer prudent advice whether you choose to correct your vision with eyeglasses, contact lenses or LASIK surgery. We only recommend treatment after a thorough eye exam and informed discussion with the patient determines their needs.Learn More
The doctors at Coastal Bend Eye Center want to help you determine whether or not you are a candidate for LASIK. In order to better understand if you would be a good candidate, please take a moment to complete our online self-evaluation form.
Start your journey to clear vision today!Learn More
Cataract surgery is the removal of the eye's cloudy natural lens (cataract), replacing it with a clear lens implant (known as an intraocular lens or IOL). Cataract eye surgery is the only way to treat cataracts, and it is a simple, safe and effective procedure. In fact, it is the most frequently performed outpatient procedure in the United States.
At Coastal Bend Eye Center, we also offer active lens implant choices which provide a full range of vision, helping you see like you did 30 years ago.Learn More
Regular eye exams are an invaluable tool in maintaining your eyes' health by detecting and preventing disease. Early detection of any problems can reduce the risk of further harm and allow for a choice of treatment options.
Patients should see their doctor for a comprehensive eye exam every one to three years, depending on their age, risk of disease and overall physical condition. Children should have regular tests to ensure the proper development of their vision and prevent any interference with their academic achievements. Older adults are often at a higher risk for eye conditions such as glaucoma, macular degeneration and cataracts. Even if your eyes are healthy, you should still have a regular eye exam to detect any problems as soon as possible and begin necessary treatment.Learn More
A great pair of eyeglasses fits comfortably and esthetically compliments your face. Our experienced opticians know that it takes much more than measuring pupillary distance deliver their best in eyewear. Frame shape, material, width, hight, lens position and pantoscopic tilt all affect vision and comfort and must be adjusted for each patient. We offer hundreds of quality designer frames at a reasonable price.
Lens materials and treatments compliment an up to date prescription for glasses to help make the most of your vision. Our digital lab produces lenses with 1/100 diopter accuracy and offers custom progressive bifocal lenses. High index lens materials make glasses thinner and lighter. Surface treatments to reduce scratches, glare and smudges offer greater clarity of vision.
We know shopping for eyeglasses can feel tough, so let us help you!Learn More


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Enabling you to identify and mitigate the intrinsic risk in your operations, supply chains and business processes.
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Evaluating how your products and services meet and exceed quality, safety, sustainability and performance standards.
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Formally confirming that your products and services meet all trusted external and internal standards.
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Intertek delivers the expertise you need to get your products safely, efficiently, and effectively to market anywhere in the world.
As the global leader in testing, inspection and certification, it is our business to be at the forefront of the safe execution and delivery of products to their intended markets. Our capabilities in a variety of industries—electrical and electronic products, medical devices, IT and telecoms, toys and games, juvenile products, textiles and apparel, food and more—offer an interconnected knowledge base that brings solutions to everything from regulatory issues to supply chain challenges, and beyond.
With engineers and specialty staff at more than 1,000 locations in over 100 countries around the globe, our aptitude for regulatory standards and requirements, certification needs, performance and quality programmes, ongoing industry, market, and consumer trends and advancing technology is unparalleled. It is our constant mission to be informed, engaged, and to provide services that ensure our clients are never left behind.
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Tailor programmes to meet regulations and consumer demands for your apparel and textile products.
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Following are excerpts from footage of a Fatah rally held in Gaza, which aired on PA TV on December 31, 2012.
Speaker: We shall never forget, accept, or ignore... Fatah has taught me courage and bravery, and how one should never keep silent about the truth.
We shall never forget the martyr of the Arab and Islamic nations, the martyred, venerable leader, Saddam Hussein Al-Majid.
Crowd applauds
Speaker: As you well know, today is the anniversary of his martyrdom.