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SARS-CoV-2 research
The McCray Lab (Univ IA, USA) used DsiRNAs to develop a protocol for efficient small RNA delivery into airway epithelia. The resulting method was then used to study miRNA regulation of gene products involved in airway fluid and electrolyte transport, cellular mechanisms linked to cystic fibrosis.
Research in Dr Paul McCray's laboratory (Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA) is focused on epithelial cell biology, host–pathogen interactions in the airway, and the pathogenesis and treatment of cystic fibrosis (CF). CF patients suffer from improper fluid and electrolyte transport, which leads to salty sweat, extremely viscous mucus, and chronic lung disease. An important aspect of Dr McCray's work is investigating the efficacy of small molecules as therapeutics for CF. His research team first designed experiments to improve small RNA delivery to airway epithelia, and then used the most efficient delivery technique to study miRNA regulation of gene products involved in airway fluid and electrolyte transport.
The CF transmembrane conductance regulator (CFTR) anion channel, which is encoded by a gene that is mutated in individuals who suffer from CF, is one of the major proteins involved in fluid and electrolyte transport. CFTR is translated from a low abundance mRNA in airway epithelia, yet is a principal anion channel that regulates chloride and bicarbonate, which control the volume and composition of secretions in the airway [1].
In a recent publication, Dr McCray, Dr Beverly Davidson, and others, including collaborators from IDT, describe the discovery of an miRNA-regulated gene network that influences both the transcription of the CFTR gene and the post-translational processing of the CFTR protein [1]. In order to understand how this newly discovered miRNA regulation affects CFTR expression, the lab first needed to develop tools to manipulate CFTR transcript levels.
siRNA methods are useful for understanding how endogenous miRNAs regulate mRNA transcripts because of their similar mechanisms. As with all siRNA experiments, the first technical hurdle is to get these RNA duplexes into cells. In a recent article [2], scientists in Dr McCray's and Dr Davidson's labs examined the efficiency of in vitro delivery of Dicer-substrate siRNAs (DsiRNAs) to airway epithelia using a model system where the cells form a well-differentiated, pseudostratified columnar epithelium in culture, a robust model that mimics in vivo airways.
Previous studies inferred successful cell entry from observed cell fluorescence when an oligo with a large fluorophore attached to the N- or C-terminus was introduced on the cell surface or administered in vivo [3]. What is unknown about these methods is whether the cell entry pathway is altered by the addition of a large molecule to the oligo, or whether the fluorophore is separated from the oligo during the process resulting in entry of the fluorophore, but not the oligo.
IDT oligonucleotides internally labeled with DIG (Figure 1) provided the group with a novel reagent for monitoring entry of DsiRNAs into cells. Using these oligos for immunolocalization in well-differentiated cells, the researchers found that the oligos adhered to the cell surface and did not enter the cells. Looking back at the process of cell differentiation in culture revealed that after being introduced onto a filter membrane, primary cells spend the first few days recapitulating their differentiation process before forming the new epithelium. When appropriate transfection reagents are used, oligos introduced to cells during the first 4 or 5 days after plating entered the cells satisfactorily; however, after 5 days, oligo entry into the cells was blocked (Figure 2). While the blocking mechanism remains unclear, the group is conscious of the effect of timing on oligo entry.
Figure 1. Structure of digoxigenin (DIG).
To enhance cell entry properties, the researchers compared transcriptomes of poorly differentiated and well-differentiated cells using gene expression studies. They then used the Connectivity Map [5] to identify drugs that might drive the gene expression profile of well-differentiated cells toward that of poorly differentiated cells. From these studies they identified specific methods to enhance oligonucleotide delivery into well-differentiated cells. The scientists chose potent internal DIG-labeled DsiRNAs against HPRT with strong signals for cell entry and monitored entry using fluorescent-labeled anti-DIG antibodies. Once the group has achieved efficient DsiRNA delivery in the in vitro epithelial airway model, they will begin testing in animal (pig and ferret) models developed in their labs, which present lung disease that resembles CF in humans.
Figure 2. Efficiency of DsiRNA delivery is reduced over time. Pig airway epithelial cell cultures were transfected with DIG-labeled DsiRNA against HPRT (IDT) using a peptin transduction domain–double-stranded RNA-binding domain (PTD-DRBD [6]) fusion protein for delivery. Cells were processed with fluorescently labeled anti-DIG antibodies 2 hr after transfection and observed by confocal imaging (x–z stacks). (A) 2-day old cells; and (B) 5-day old cells. Blue = nuclei; green = DIG-labeled oligonucleotide.
Mutations in the CFTR gene, the most common of which is ΔF508, result in the development of CF. ΔF508 is a 3-base deletion in the gene, which occurs in ~70% of mutant alleles and causes protein misfolding [7]. The misfolded protein is directed to the proteasome and, therefore, none of it gets to the cell surface to function as an anion channel. With their newly-developed delivery system, the researchers were able to show that by introducing a miR-138 mimic (IDT) to knockdown SIN3A protein, they could partially rescue the phenotype—some of the misfolded protein escapes the quality control mechanism of the cell and reaches the cell membrane to serve as a partially functional anion channel (Figure 3). SIN3A is a transcriptional regulator that binds to the chromatic insulator protein CCCTC-binding factor (CTCF), and the CFTR gene locus contains functional CTCF-binding sites.
Dr McCray is excited about the discovery of the effect of miR-138 because it sheds light on a mechanism for CFTR processing that had not been previously recognized. The lab has used this new information to perform transcript profiling and identify SIN3A regulated genes in airway epithelia to gain insights into how the CFTR protein is processed. Additionally, the findings open up a new way of thinking about therapy for CF through the rescue of CFTR protein function.
Figure 3. Effect of wild-type and mutant CFTR on CFTR transcription and protein biosynthesis. The working model shows the proposed steps in miR-138 regulation of WT and ΔF508 CFTR.
The researchers do not consider suppression of SIN3A expression an appropriate therapeutic approach because SIN3A regulates so many genes and, thus, it is likely to be too nonspecific as a therapeutic target. However, identifying gene products in the network that regulate processing of CFTR may reveal a small subsection of these differentially-regulated genes that are key players involved in this phenotypic change. Those gene products can then be used as drug targets.
The CFTR/miR-138 project benefited from a close collaboration with researchers and DsiRNA experts at IDT. Dr McCray noted, "Throughout this CFTR/miR-138 project the IDT group really helped us with development of the reagents we used. We performed a significant amount of screening to identify efficient oligos to knock down SIN3A and CFTR and to make a robust miR-138 mimic. And once we identified efficacious oligos, IDT chemically modified them to make them nuclease resistant. The modified oligos allowed us to study their effects on CFTR processing and function many days after transfection; we could study the cells 2 to 3 weeks later! We added the oligos when we seeded the cells for the reasons I described in the first [DsiRNA] project. Because we plate these primary cells at a high density, they undergo very little cell division, so these oligos would remain intact and could participate in regulating gene expression for the entire 2–3 week period of the experiment. It provided us a really robust tool to look at the questions we were asking. That was an enormous contribution to our project."
Dr McCray and colleagues intend to combine their small target delivery findings with data obtained from their miRNA studies for therapeutic purposes; e.g., targeting pro-inflammatory cytokines such as IL-8 or delivering an oligonucleotide to rescue the function of mutant genes like ΔF508.
DsiRNAs are chemically synthesized 27mer duplex RNAs that can have increased potency in RNA interference experiments of up to 100-fold when compared to conventional 21mer siRNAs [4]. DsiRNAs are also able to effectively target some sites that 21mers are not able to silence [4].
Traditional 21mer siRNAs are designed to mimic Dicer products and therefore bypass interaction with the enzyme Dicer. Dicer has been shown to be a component of RISC and involved with entry of the siRNA duplex into RISC. DsiRNAs are designed to be optimally processed by Dicer and can show increased potency by engaging this natural processing pathway. Using this approach, sustained knockdown has been regularly achieved using subnanomolar concentrations. New design rules specific to DsiRNAs have been developed and are available only from IDT. Contact us at email@example.com for more information.
Dr Paul McCray trained as a pediatrician and then subspecialized in pediatric pulmonary medicine. During his specialist training, Dr McCray became familiar with cystic fibrosis (CF). His research has since largely been focused on CF, airway epithelial cell biology, and host–pathogen interactions in the airway. He is interested in providing a better understanding of the disease and in developing new therapeutics for CF. More information about the McCray Laboratory is available at http://mccraylab.genetics.uiowa.edu.
In addition to directing a research laboratory, Dr McCray is currently the division director for the Allergy Immunology Pulmonary Division in the Department of Pediatrics, and vice chair for research in the Department of Pediatrics, at Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Dr McCray is also a member of The Recliners, a 7-member band that has an eclectic repertoire, including rock and roll, blues, ballad, and Turkish folk music.
Nicola Brookman-Amissah, PhD, Director of Scientific Communication, IDT.
Published Mar 29, 2013
Revised/updated Nov 14, 2016
Review other DECODED Online newsletter articles on small RNAs and functional genomics.
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Hi Dolla Honey (Feat. Proteja) - Otis Freestyle [Female Unsigned Hype]
"As you can see by now it's not over Hi Dolla Honey is back and she's prepared to show the haters and non believers what a non-stop grind does. Follow her on twitter @hidollamuzik and on the web www.hidollamuzik.com and on www.youtube.com/hidollahoney S/O to WSHH we are not stopping . Hot new remix videos coming soon .New single "Bout my Money" coming Soon.... Proteja coming soon... Hi Dolla Muzik is looking for that heat if you got it we might sign you get at us @hidollamuzik.."
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So here is something I'm trying to figure out today. I just set up a Google Voice number. I want to set up a custom voicemail greeting using an mp3 I have on my computer.
If I put the mp3 on my phone, is there any way to play it while I am calling Google Voice to record my greeting?
Or, is there a way I can connect my computer to play the mp3 into my phone (without holding it up to the speak)?


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Sabres deal Vanek to Islanders
Buffalo receives Moulson, draft picks
With the Sabres posting the NHL's worst record through the season's first month, Buffalo already is looking toward the future.
The Sabres traded left winger Thomas Vanek, one of the top scorers in franchise history, to the New York Islanders on Sunday night. Buffalo received left winger Matt Moulson, a first-round pick in the 2014 draft and a second-round selection in 2015.
Moulson and Vanek are both 29, and both are in the final year of a contract. Vanek is completing a seven-year, $50 million deal, while Moulson is concluding a three-year, $9.4 million contract.
"It was a deal that was off and on here for a while," Sabres general manager Darcy Regier said. "It was something we feel we needed to do. ... It was important to get first- and second-round picks.
"You have to believe in what you're doing. It's exciting when you can get young players and see them grow. The hard part is when you don't win games while they're growing. It's a long-term plan, and you've got to deal with the two."
Vanek ranks fifth in Sabres history with 254 goals and 10th with 497 points. He is fourth in power-play goals (106) and fourth in game-winning goals (41). Vanek has four goals and five assists this season.
Moulson has six goals and three assists this season.
"It's sad to leave people you care about and love behind," Moulson he told ESPNNewYork.com. "I think over the years I've shown my want to be a part of the organization and turning around the team into being successful. I guess, obviously, in the long run, they didn't feel the same."


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|You Need Success to Be Happy
You are a responsible and serious person. You like to do things well.
Reaching your goals is very important to you, and you don't like getting sidetracked.
You feel great when you are mastering new tasks and solving problems. You believe in hard work.
Nothing makes you feel worse than feeling like you are doing a back job.


text:
- Did you mean
- need full harvest required increase focus safety
Search results
CHAIRE Inaugural Research Symposium
species and presentation style. Each also fall into at least one of CHAIRE's focus areas which are Welfare ...
Cressleaf Groundsel in Hay
While this is not a new weed prevalence has been increasing, causing concern for many livestock ... and emerges as a rosette in the fall, then bolts, flowers, and goes to seed in the spring. Bolting ... established in the field. Take note of fields with Cressleaf Groundsel in them or nearby for increased ...
How CFAES is helping Ohio farmers weather COVID-19
Safety Team, is providing science-based recommendations on best operating practices for farms and farmers ... processors on issues such as finding local processors, finding new markets, and starting or increasing direct ...
Recommendations for Soybeans Planted in June
the growing season soybeans are planted, the higher the yield increase due to narrow rows. Seeding ... rate. Higher seeding rates are recommended for June planting dates. The final (harvest) population for ...
Ohio State offers tips for vendors, consumers when shopping at farmers markets amid COVID-19
groups are continuing to plant, harvest, and market foods directly to the public, said Shoshanah Inwood, ... practice for everyone's safety in response to the coronavirus pandemic, she said. "For example, you may see ... on COVID-19's effect on produce safety; reaching new markets; pivoting to new marketing platforms; ...
Alfalfa Continues to Mature
requirements than lactating dairy cows. Begin harvesting grasses as soon as you see a good harvest window. The ... across Ohio are ready to be harvested for high quality forage (see table below). Producers in dryer ... regions were able to start harvesting alfalfa fields over the weekend. Western Ohio has had larger ...
Chow Line: Canning expected to be big this year amid COVID-19
gardens this year. For example, online searches for "growing vegetables from scraps" increased 4,650% in ... decreased incomes, more time at home, and an increased sense of an unknown future have many people wanting ... of up to 300% increases in seed sales this spring. "As a result, we expect home food preservation to ...
Leasing Your Land for Shale & Solar
governments may have on shale and solar projects. These sessions will be focused on surface and subsurface ... webinar will be focused on utility-scale solar projects while the other two sessions will cover oil and ... persons needing assistance to participate in Extension programs. If you require accommodations to attend ...
It's about learning new skills and how to persevere
4-H's focus on learning by doing. Among them are the Stay connected! website, with links to virtual ...
New CFAES groups assist Ohio food producers, consumers during pandemic
continuing to plant, harvest, and market food directly to the public allowing consumers to continue to access ... business, planting, and harvesting plans in response to radically shifted markets and public health concerns ... for worker and consumer safety. To help these essential food producers as well as consumers, CFAES ...


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The most fuel economical new Grandland X with the lowest CO2 emissions is the 1.5 SRi Nav 130PS Turbo D Start/Stop BlueInjection. If you are looking for power, the new Grandland X with the highest performance is the 1.5 Sport Nav 130PS Turbo D Start/Stop BlueInjection.
The Vauxhall Grandland X is available with the following fuel types:
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The Vauxhall Grandland X scored 5 for overall safety with EuroNCAP.
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Thought your HR monitor was just a training tool for fitness? Think again. It's actually an invaluable guide to staying safe in the mountains, says Mountain Guide Fabien Meyer.
Heart rate monitors are most commonly associated with performance sports and are an invaluable tool to improving your fitness, training intelligently and gauging your progress. But not many people realize they can help you make the right decisions in the mountains – decisions that could ultimately save your life.
"If you're not acclimatized your heart rate will be about 20bpm above normal."
How so? Heart rate data can provide an accurate guide as to whether you're acclimatized. That in turn will tell you whether you're moving fast enough to make that summit in time before the weather turns.
"You can use heart rate to see if you're going to make the summit," says Meyer, who's based in Chamonix. "If you're not acclimatized your heart rate will be far above your normal rest rate. So if you're ascending 500 m per hour normally (same activity, same weight, in your home place) at 70-80% of your HR, you will be at a heart rate of more than 85-90% of your max HR. That's going to be too high to sustain. You'll go into your lactic window after five minutes and after 30 minutes you will be obliged to slow down. And because of acidity you can not hope to come back at the same efficiency."
Using HR will help you acclimatize more effectively. ©zooom.at/Ulrich Grill
He gives the example of the classic Whymper Couloir route in the Mt Blanc massif. It's south-facing so parties have to move fast to be able to make the summit and get off in time. A heart rate monitor will help you make an informed decision as to whether you can make it.
"You have to go quite fast and ascend 400m per hour for 4-5 hours. Using heart rate you can quickly see if you can make it in a good state."
He adds that training with heart rate also works as a powerful incentive to fuel your climbing goals. Climbing is all about efficiency and moving quickly in difficult terrain, he explains. "If you do the same trip you did a month ago but with a 10% lower heart rate that's a great motivation."
Fabien Meyer is a Mountain Guide based in Chamonix, France.
Top image ©Bruno Long


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A little boy and his grandmother came to see Santa at The Mayfair Mall in Wisconsin. The child climbed up on Santa's lap, holding a picture of a little girl.
Santa's name: Mark Leonard or Santa Mark
If a picture paints a thousand words, words emanating from the mind create images more powerful than a mere picture. Welcome to my Blog, enjoy your stay!
Hi, I'm Susan Leonard, the writer of this story. I'd like to ask that you give attribution for the story. While it's not important for me to be recognized as the writer, or for my husband to be recognized as the Santa, we just
feel that by attributing the story, it gives it credibility, because it IS a TRUE story, not an urban legend. I knew the story went viral via email several years ago, and is featured on many web pages and blogs. And that's fine. But it's disheartening to see the several blogs (NOT yours!) who ridicule the meaning of the story. God chose to give little Sarah a miracle healing and we are humbly honored to be involved in some way.
The story can be found in original form on my own blog: http://susans-sea-of-dreams.blogspot.com
"The Christmas Miracle" © 1995-2011
written by Susan Morton Leonard, as told to her by her husband, Mark Leonard aka Santa Mark
Hope you have a very blessed Christmas!


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MoronWatch: The first in (what I hope will be) a regular moron-of-the-week feature.History has just been made. The world's leading human rights organisation, Amnesty International has finally, belatedly, accepted that sex workers are people with rights, and has called for their trade to be decriminalised.
For liberals, this kind of decision would once have been a no-brainer. But liberalism has become infested with puritanical, authoritarian ideas, and many liberals are highly illiberal when it comes to core issues of individual liberty – most of all, when sex is involved. Almost 4 years ago, I began to wake up to this, and wrote a piece about the Guardian's sexual hang-ups. My observation that the secular left and the religious right had almost blurred into one entity was one of the catalysts that ended my Guardian subscription, and began my growing disenchantment with the increasingly conservative political left.
It was unsurprising then that the Guardian, so often a flag-waver for human rights, could not bear to apply its regular principles to the yucky issue of prostitution. In the run-up to Amnesty's vote, a Guardian editorial implored the organisation to focus on other things. The piece was dishonest, suggesting that Amnesty was calling for some kind of global libertarian-inspired, unregulated free market in sex, which it most certainly was not.
The editorial almost reached self-parody, suggesting that Amnesty should pay heed – not to sex workers who were overwhelmingly in favour of the move – but to Hollywood celebs: "The letter signed by film actors who are normally reliable allies of Amnesty shows how damaging it is." Don't listen to the dirty hookers, listen to Kate Winslet!
The idea that actors know more about prostitution than prostitutes was widespread, and seemed to form a key part of the case against decriminalisation. But in this Internet era, sex workers can (for the first time) organise en-masse and speak for themselves. So we had the wonderfully named article Sex workers tell Lena Dunham, other celebs, to STFU about shit they don't understand. And this was capped by an even more perfect tweet from the pornstar Stoya:
Given that the workers themselves wanted to be decriminalised, and that the evidence overwhelmingly suggests that this would make life better and safer for them, the Guardian and other opponents were reduced to relying on the dubious link between trafficking and sex work, and the accompanying implication that sex workers are largely the powerless "trafficked" victims of global patriarchy. The left's favourite nonsense-word-du-jour, neoliberalism, often appears in this false argument: IT'S THE NEOLIBERALS MAKING WOMEN DO TERRIBLE THINGS! Replace "the neoliberals" with "Satan" and you effortlessly switch between the "progressive" and the fundamentalist argument.
In fact, the trafficking argument against sex work is often a cover for anti-immigration attitudes (yes, they exist on the left too, just a little better hidden). When police raid brothels in the name of "saving trafficked women", they often arrest those without valid papers and send them off for deportation. And thus, we have supposed progressives and feminists supporting anti-sex, anti-immigrant policing activities. Where do the liberals end and the far-right begin?
As if to underscore its own hypocrisy, the Guardian's front page was yesterday dedicated to people who had truly been trafficked and exploited: Lithuanians who had been trafficked into the UK and exploited in the egg industry. There was no Guardian call for eggs to be banned. Illegal immigrants who take on low-paid agricultural work are allowed to have employment rights. Those who take on higher-paid sex work are not.
The decay is widespread: the trade union Unison has also vociferously opposed decriminalisation. And so we have, possibly for the first and only time in history, a trade union refusing to support workers in need of representation, and instead calling for the shut-down of an entire industry. Imagine if unions took this approach wherever they encountered workers being exploited: it is about as far from trade unionism as one can imagine (not all unions have followed this strange lead – the GMB for one has a branch for sex workers).
Amnesty's decision is more than symbolic. It is a part of a tide that is slowly, finally, turning. It's just a real shame that, rather than champion members of the world's oldest profession, so many supposed liberals as well as supposed Christians have chosen to turn their backs on them.


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The Calgary Flames unveiled their new third jersey Sunday, to mixed reaction from fans.
The new jersey, which will be worn by the Flames at 12 home games over the course of the 2013-14 season, maintains the Flaming C as its primary logo along with the word "Calgary." A western-style shoulder yoke and tie-down laces on the front are meant to represent western heritage, while a new shoulder patch has been created to celebrate the unique landscape of southern Alberta.
The jersey also features a new two-colour name and number font but keeps with tradition by including the Atlanta A for the assistant captain letter.
Fans were divided on the new design. On Twitter, some Flames fans posted comments like, "Very classy looking. I like them," and "Wasn't sure at first, but on closer inspection they are excellent."
However, others were unimpressed. "Looks like Walmart pyjamas," was one comment.
Calgary Flames VP of Business Development Jim Peplinski said many fans have been asking for a third jersey.
"We believe we have delivered a third jersey that will appeal to those who wanted a third jersey while adding to our classic vintage jersey and solid current jersey," said Peplinski.
"We are looking forward to playing in front of the C of Red in the new jersey which represents the city in a new unique way with the word 'Calgary' on the front," said Flames Captain Mark Giordano.
Beginning in the spring of 2012, representatives from the Calgary Flames, the National Hockey League and Reebok began the process of creating a design for the newest Flames uniform. The final product — which combines the western heritage of Calgary, the vast Alberta landscape, and the legacy of the Calgary Flames — was completed earlier this summer.


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Hard shell, succulent heart
The waters off the Danish coast are teeming with oysters. While an invasive species is taking over the beaches, indigenous oysters still thrive in the depths of Limfjord – to the great joy of culinary connoisseurs.
The midday sun hangs low in the sky over the Limfjord, its glittering waters almost the same icy blue as Niels Nielsen's eyes. A giant of a man, he has been working on ships for 23 years – as a cod fisher on his own boat and also as the captain of a tug laying cables off the coast of Brazil. "But there's no place for small children in the seaman's life," says Nielsen, laughing loud enough to drown out the drone of the boat's diesel engine. Today, 43-year-old Nielsen lives with his family beside his native Limfjord, a sound covering 1500 square kilometers in northern Denmark. He works here as the skipper of the Egon P, a small, bright-red research boat. "Let's bring up the treasure, then," says Nielsen.
The fishing gear emerges from the waves and spills its contents, black and heavy, into the boat's stern: thousands of blue mussels and dotted among them, plump starfish that evidently live very well off the shellfish. There are no flat fish in the net because "the seals and cormorants grab them," says Nielsen. Then from among the shellfish, the skipper picks out the true pieces of gold, hard and as large as the palm of his hand – dozens of magnificent specimens of the Limfjord oyster, the most exclusive item on the Nordic menu. A single one of these oysters can cost as much as eight euros at restaurants in Copenhagen. Pacific oysters farmed in aquaculture account for 94 percent of all oysters consumed worldwide; the European oyster's share of the global oyster market is a tiny 0.2 percent. Among these exceptions, the Limfjord oyster is actually a special case because the European oyster isn't farmed here; the fishermen take only wild specimens from the bed of the shallow sound.
There used to be oyster fishing grounds off the coast of Sylt and other North Sea islands, but overfishing long ago decimated stocks, making the European oyster extinct in the German Wadden Sea. That won't be happening in the Limfjord, though, as Nielsen and his colleagues from the Danish Shellfish Centre at the Technical University of Denmark (DTU) monitor the vulnerable oyster population by making test catches that provide the basis on which the fishing quotas are set. In 2018, only 300 tons of oysters were brought up, roughly ten percent of the estimated total quantity. Until now, only one out of 100 Limfjord oysters have been consumed in Denmark. Most of the catch is flown to Galicia, to Madrid and Barcelona, where restaurants impatiently await their arrival. For a long time, the Danes were not known for their gourmet palates, but rather as a nation of traders, who loved their fried bacon. But that's all changed thanks to New Nordic Cuisine. Started by top chefs like René Redzepi of the Noma restaurant in Copenhagen, that trend is now making its way into hinterland kitchens. Everywhere the emphasis is now on regional and seasonal ingredients, kelp from the coast, for example, and sea buckthorn form the dunes. The European oyster barely survives further north than the Limfjord. Redzepi cites the low water temperature as the reason for their being the world's best: the colder the water, the slower the oysters' growth and the more intense their flavor.
Nielsen places an oyster in a folded tea towel. This will protect him should his knife slip. With a practiced hand, he slits the tough adductor muscle and removes the top half of the shell to reveal the mollusk in its mother-of-pearl bed. A few drops of lime juice and I slurp it down raw. Fantastic!
The daily life of an oyster is pretty monotonous. It sits in one spot and pumps water through its gills, filtering out the microorganisms that form its diet. You could also say that it spends its life concentrating the taste of the sea. Limfjord oysters feel surprisingly meaty on the tongue. Novices have to steel themselves the first time they shuck an oyster out of the bottom half of its shell and put it straight in their mouth, even if it is a well-known fact that the brainless mollusk feels nothing. For Erwin Lauterbach, chef at the Lumskebugten restaurant in Copenhagen, it's the same as with other sophisticated tastes: practice intensifies the experience. "No one enjoys their first oyster," says Lauterbach, "it's an acquired taste." An oyster need not even play the aromatic lead in a dish, it even unleashes its magic when concealed, in the form of a few chopped oysters mixed into ox tartare, for instance: "Then you find yourself wondering about a certain saltiness that lends something amazingly unexpected, a lightness, to a recipe." A daily dish might be creamed potatoes with two or three oysters as a side, "simple and festive at the same time – that's oysters for you."
Klaus Louring likes them best the way they were eaten in the Stone Age. Before we try Stone Age preparation, we first have to become hunters and gatherers ourselves, on the island of Fanø in the Danish Wadden Sea. Louring, 55, was a seaman in his youth and worked on container ships sailing between Europe and Asia. Now he's a coastal ranger on Fanø, where he initiates school classes and tourists in the mysteries of the Wadden Sea. At low tide, he leads his listeners out to the young Pacific oyster beds. Since the 1990s, walkers on the mudflats have been able to observe how this particularly invasive species has been establishing itself and spreading in the shallow waters along the Danish coast. The Pacific oyster has a hard, elongated shell with sharp edges. These wild oysters are almost certainly the offspring of oysters cultivated in the many aquaculture operations around the North Sea: Eggs are fertilized by semen in the water, and then the current carries the larvae a long way off. No one can control where the oysters come to rest. "In the Wadden Sea, the Pacific oyster has only one enemy," says Louring, as we find the first few in the mud, "homo sapiens with his excellent appetite."
So far, there has been no specific research into this invasive species' potential impact on the Wadden Sea. It is unlikely to affect the European oyster, which grows at depths of up to 30 meters, but it does seem likely that it could displace indigenous species, such as the blue mussels. "In some places, both the mussel populations and individual specimens are becoming smaller," says Louring. It could have something to do with the fact that oysters, like mussels, are dependent on the microorganisms that the tides wash into their gills. "An oyster filters 12 liters of water an hour," Louring points out, while a mussel manages only six liters at most. Fewer mussels would mean trouble for the millions of migrating birds that replenish their energy reserves in the Wadden Sea before continuing their flight south. The birds can crack open a mussel, but not an oyster. "The more we take, the better," says Louring.
We walk almost two kilometers out onto the mudflats, past "spaghetti factories," as Louring calls the tiny piles lugworms leave behind on the mud. Lawyer Snorre Kehler is holding his little daughter Viktoria's hand. Their pail soon fills up with the fresh shellfish, many of them big as a man's fist. "We want to cook a Mediterranean-style meal with them back at our holiday home," says Kehler's wife, Natasha, an IT consultant, "we'll bake them in the oven with a little parmesan cheese, parsley and garlic on top – they taste best that way." But we also sampled a few right there on the beach, where our guide lit a campfire. "In the Stone Age, they only had knives made of flint, and you can't open an oyster with one of those," says Louring, laying a few oysters into the embers. After a few minutes on the fire, the liquid inside the oyster begins to boil and expand and – the shells plop open.
The people of Ertebølle on the Limfjord were already tucking into European oysters 7400 years ago, as we know from a gigantic pile of oyster shells discovered by archeologists along what was once the coastline. The pile is 140 meters long, 20 meters wide and two meters high, an accumulation of the oyster shells Stone Age people gathered and split open over their beach fires over a period of 1500 years. Among the shells, the archeologists also found fish bones and pottery shards with traces of burned-on bouillabaisse still clinging to them. The remains of human skeletons were also discovered in the stack. An examination of the bones revealed that the people of that time were healthier than their descendants, who became farmers and lived off cereals and the animals they kept.
Just how many Limfjord oysters there will be in the future also depends on their reproduction strategy. A stay-at-home that holes itself up behind the hardest calcium carbonate needs to be creative if it wants to reproduce: Oysters change their gender. Most of the time, the Limfjord oysters are male, says Lene Friis Møller, a marine biologist at the DTU's Danish Shellfish Center, "and they only become female and produce eggs in fine weather summers, when the water temperature remains above 18 degrees over a longer period, and there are ample supplies of plankton in the water." In 2018, Denmark enjoyed an exceptionally long, warm summer – ideal conditions for oyster offspring. It takes a Limfjord oyster three years to grow to 100 grams – serving size. It seems good times lie ahead for fans of the world's best oysters.


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Google is working on a technology that, if perfected, would prevent about 35,000 deaths per year in the United States and 1.2 million deaths per year worldwide.
To put that number in context: About 23,000 American men and women will die of leukemia in 2012, according to the National Cancer Institute.
But while the technology Google is working on isn't the cure for cancer, it's pretty impressive.
What is it?
Self-driving cars.
According to the U.S. census, 33,808 people died in car crashes in the U.S. in 2009 — 37,423 in 2008. According to the World Health Organization, 1.2 million people die in car crashes around the world each year.
A source familiar with Google's self-driving car program tells us that one of its primary goals is to eliminate the ~99 percent of those deaths that are caused by "human error."
That's obviously a lofty goal.
It's certainly admirable … but is it achievable?
There are some data points to consider before answering that question.
- Google's cars are much better drivers than you. Self-driving cars can "see" in 360 degrees. They do not get tired, drunk, old, or enraged. They do not have teenage hormones. They know exactly how to stay out of other drivers' blind spots. They can anticipate and adjust due to variables impercitible to humans.
- Google's self-driving car program is much further along than you might guess in terms of consumer-friendliness. When you hear the phrase "self-driving car," you might imagine a car interior stuffed with wires. Don't. We understand that the interior gadgetry associated with Google's self-driving cars is minimal these days. Imagine a few extra buttons on the steering wheel no more complicated than "cruise control," and a user-interface that's as consumer-friendly as an Android tablet.
- It's much easier for Google's self-driving cars to operate on the highway than on the street. On highways, the traffic is all moving in the same direction at generally the same speed in neatly divided lanes. On surface streets, cars can come from anywhere and go in any direction. The data is messier. Because of this, our guess is that auto-drive will be a mode that is only available for a driver to enable on highways in particular conditions in certain lanes. Again, imagine "self-driving mode" as something similar to "cruise control." This puts a limit on the number of lives self-driving cars can save. In 2011, about 7,000 of the approximately 35,000 car accident deaths in the U.S. took place at intersections. Still: Google's cars would almost immediately cease the more than 3,000 deaths each year due to distracted highway driving.
- Google is still facing a couple technological challenges. Its cars still have trouble in the snow because their laser sensors can't "see" the road to tell if it's the same as the one inside their computer brains.
So … is Google's goal achievable?
And when you're talking about 35,000 lives in the U.S. each year, and 1.2 million worldwide, "mostly" is pretty incredible.
Get the latest Google stock price here.


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P4 necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 30 diseños de 13 diseñadores freelance.
Market Geometry Pioneers
Our school is for stock, futures and currency traders. It is located in Prescott, Arizona and is run by Timothy Morge a professional trader, author and educator.
Our school teaches students how to become consistently profitable traders. We also share ideas and learn from each other. Our student body includes people from all over the world and from every demographic. We stress the need to respect the market but to also have fun because if you're not having fun you shouldn't be doing this.
Our audience are our students and people who want to learn more about our school.
We want to try to combine the city of Prescott's seal (attached here file called prescottlogo.tiff), our logo (mg.png) and maybe the state flag of Arizona.
What is important here is that the Prescott seal contains an outline representing mountains but that outline also looks like a price chart which is the major tool we use to trade markets. An example of a price chart (pricechart.tiff) is also included just to give you an idea of what I mean by a price chart.
With all this said, if you have other ideas please feel free to express them. We aren't creative people and look to all of you to help us out. We will not reject a submission just because it doesn't contain all the elements we've expressed above.
We also want to incorporate the following text:
"Market Geometry Pioneers" and "A Proud Member of Timothy Morge's Inner Circle"
Thanks for considering entering your work in our contest!
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Enberg's Play About McGuire Still Going StrongPosted by jstevrtc on September 28th, 2010
Are you a college basketball fan, but also long to be a patron of the arts? Well, get yourself to a performance of Coach: The Untold Story of College Basketball Legend Al McGuire, a one-man play written by none other than the inestimable sportscaster Dick Enberg about the former Marquette coach. McGuire, who died of leukemia in 2001, was a good friend of Enberg's as well as his former television broadcast partner. Enberg debuted the playat Marquette in 2005 and it's been traveling the country since then, but we mention it now because two of its upcoming performances have special significance.
During its run, the play has garnered praise both for the personal and touching nature of Enberg's tribute to his friend as well as the portrayal by actor Cotter Smith, an award-winning stage actor who you may remember most recently from the HBO movie about the life of Jack Kevorkian entitled You Don't Know Jack.
The two upcoming performances we mentioned above are the ones taking place at Belmont Abbey College on October 9th and at Indiana University on October 23rd. As just about every college hoophead knows, McGuire led Marquette to the 1977 national championship in his final season as a head coach. Before he took the head coaching position at Marquette in 1964, though, he spent seven years at Belmont Abbey, the site of his first head coaching job. Enberg is an undergraduate alum of Central Michigan University, but holds master's and doctoral degrees from Indiana in the field of health sciences. The two shows at those venues will be special, indeed. Mr. Enberg — who we should actually refer to as Dr. Enberg, though he'd probably be the first to quell that notion — is scheduled to appear at both of those performances.
McGuire debuted as a college basketball analyst for NBC in 1977 with Enberg and Billy Packer, and is seen as the first real "character" in the realm of basketball broadcasting. He was always insightful and interesting, but the guy could be downright zany, to put it mildly. Who could ever forget this:
Enberg is one of many sportscasters who sees McGuire as having paved the way for future commentators to have fun and show more of their true personalities (we're lookin' at you, Mr. Vitale) on the air. Understandable, then, is that tagline on the playbill — a quote from Enberg about his subject: "He's the most unforgettable human being I've ever met, and there's nobody in second place."


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As cars get ever more technically advanced, it's important to look back and see the roots of what we now take for granted — and maybe find old ideas with modern relevance. These are Jalopnik readers' choices for the most advanced cars in each decade of the past hundred years.
Welcome back to Answers of the Day — our daily Jalopnik feature where we take the best ten responses from the previous day's Question of the Day and shine it up to show off. It's by you and for you, the Jalopnik readers. Enjoy!
Illustration: Porsche
1911-1920: Cadillac Type 53
Suggested By: bassumarus
Why it was state of the art: Early automobile controls were a jumbled hodgepodge of levers, pedals, cranks, slides and indicators that varied wildly from vehicle to vehicle. The Type 53 rationalized the entire mess and implemented the standard vehicle-control layout that persists to this day. Other significant features included such advances as an early V-8 engine and an electric starter.
Photo Credit: New York Public Library
1921-1930: Lancia Lambda
Suggested By: Mack Totally Board 41
Why it was state of the art: Vincenzo Lancia deserves far more recognition than he gets for the technical prowess of the products that bear his name. The Lambda pioneered two major technical breakthroughs: the car's structure was a monocoque/unibody, extraordinarily stiff for its time, and the wheels were sprung independently. The oddly sleek machines were a major step forward in handling and roadworthiness.
Photo Credit: Rex Gray
1931-1940: Cord 810/812
Suggested By: chrisdraper2007
Why it was state of the art: The coffin-nosed Cords were Art Deco shapes wrapped around high technology: front-wheel-drive, preselector gearboxes, superchargers on the 812, advanced suspensions and safety and convenience features like variable-speed wipers and a radio. The disappearing headlights aren't notably advanced technically, but aesthetically — like the rest of the car — they were groundbreaking.
Photo Credit: Jack Snell
1941-1950: Tucker Sedan
Suggested By: waveridin1959
Why it was state of the art: Preston Tucker's huge, radical aircraft-influenced sedan was a monument to progressive thought and intelligent engineering. Only 51 of the rear-engined, independently-suspended cars were built before the company was overcome by financial crises — propagated, many say, by the powers in Detroit that were intimidated by Tucker's ambitions.
Photo Credit: Rex Gray
1951-1960: Citroën DS
Suggested By: For Sweden
Why it was state of the art: Everyone's favorite Gallic starship remains one of the most ridiculously overengineered and technically ambitious vehicles to see mass production. While Detroit was busily futzing with tailfins and chrome, the French redefined automotive luxury. Some say the DS's systems were a technological dead end; some say everyone else is still catching up.
Photo Credit: Denis De Mesmaeker
1961-1970: NSU Ro80
Suggested By: zacarious
Why it was state of the art: This slightly oddly-proportioned sedan was a repository for every advanced idea about car tech in the late Sixties: Wankel engine, front-wheel-drive through a semiautomatic gearbox, four-wheel disc brakes, a long wheelbase with tons of interior room, surprisingly good air-drag figures. Reliability issues, especially with the early Wankel, damaged its reputation but not its influence.
Photo Credit: Stokpic
1971-1980: Saab 99 Turbo
Suggested By: Snabb-SAAB - In mourning
Why it was state of the art: Saab was one of the very few automakers whose products actually got better and faster and more interesting during the Malaise. The 99 Turbo was their statement of intent: the fuel-injected four with its very advanced turbo system powered an odd-but-pleasant-looking car that combined levels of comfort, practicality, and safety that set benchmarks then and are still respectable today.
Photo Credit: Staffan Vilcans
1981-1990: Porsche 959
Suggested By: Gamecat235
Why it was state of the art: When the Porsche Gruppe B show car was displayed at the Frankfurt show in 1983, it was so advanced that it was hard to take seriously. When the production version was released in 1986, complete with torque-vectoring all-wheel-drive and composite body panels and an engine once removed from a 962, it was still playing its own game. Twenty-five years later other companies are just starting to match it.
Photo Credit: Philipp Lücke
2.) 1991-2000: McLaren F1
Suggested By: DasWauto - Disregard politics, acquire cars
Why it was state of the art: Not as complex as the 959 but several steps forward in other ways, the F1 remains Gordon Murray's masterwork. The carbon-fiber chassis holds an enormously powerful BMW V-12 with pioneering variable valve timing, a fascinatingly compact gearbox, a perfectly tuned suspension...and very little else. It was so focused that the race car did not differ materially from the street car. In our current age of computer overload, the F1 is a lesson in high tech in service of purist intent.
Photo Credit: Brian Snelson
2001-today: Honda FCX Clarity
Suggested By: tganno1292
Why it is state of the art: As automakers begin to investigate a world past fossil fuels, the most advanced cars on the road today are the ones that look to very different propulsion systems. As batteries continue to have frustrating limitations, fuel cells are showing more promise. The brilliant part of the Clarity is that it packages this tomorrow-tech in a rather normal-looking and normal-driving car; it's progress without discomfort.
Photo Credit: American Honda Motor Company, Inc.


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Corsair officially launched the companies first generation USB 3.0 Flash drives on May 19th, 2011 and more recently on September 9th, 2011 they announced the launch of their second generation USB 3.0 Flash drives. Legit Reviews got our hands on one of these new '2nd generation' Flash Voyager 3.0 16GB drives and just had to run some performance tests on it to see how these new drives perform!
|Model Number
|Max Sequential Read
|Max Sequential Write
|55 MB/s
|12 MB/s
|70 MB/s
|13 MB/s
|70 MB/s
|19 MB/s
|79 MB/s
|21 MB/s
In the updated series Corsair currently offers an 8GB and a 16GB drive. You can tell that is is a second generation drive as the second generation drives have the letter 'S' at the end of the part number before listing the capacity. The newly updated drives have higher performance than the previous generation drives on both read and write performance! The drive performance changes between generations are due to component change. The reason that the 16GB drives perform better than the 8GB drives is due to the USB 3.0 controller and density of the MLC NAND Flash. Usually with USB and Solid-State Drives the performance improves as the capacity increases, but that isn't always the case. For this review we will be looking at the CMFVY3S-16GB.
Corsair's been using the same looking proprietary all-rubber housing for many years, but that is okay as it has been found to be durable and water-resistant. The Corsair Flash Voyager 3.0 features a removable cap and a hole on the bottom of the casing to secure a lanyard to. The Corsair Flash Voyager 3.0 drives are rather large compared to other brands, but they have actually decreased in size compared to the original Flash Voyager 2.0 drives that came out over five years ago. The measurements on this drive is 73mm x 22mm or 2.87″ x 0.87″ for length and width. The Flash Voyager was designed for ergonomics, but doesn't look bad at all.
Taking the cap off you can see the SuperSpeed USB 3.0 type A connector. USB 3.0 is clearly the future and most all desktops and notebooks that are in stores today feature at least one or two of these ports on them. SuperSpeed USB 3.0 has a 5 Gbps signaling rate offering 10x performance increase over Hi-Speed USB 2.0. This is why you want a USB 3.0 Flash drive as they have the ability to go faster than USB 2.0 devices. Notice we said ability as it all depends on what components are being used inside. Notice that the capacity is laser etched into the metal housing on the USB connector to clearly show what capacity the drive is.
Comments are closed.


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GENERAL TERMS? Powerbock is the general name used for spring loaded jumping stilts after the original inventor and patent holder Alexander Boeck.Powerbocking or Pro-Jumping refers to the activity / sport of using these jumping stilts.Powerbockers or Pro-Jumpers refers to the user using the spring loaded jumping stilts. WHAT ARE PRO-JUMPS?Pro-Jump is the name given to our brand of powerbocks. Projump stilts are created using patent protected technology and are provided at an unbeatable price. Pro-Jump are fully authorised by the original inventor Alexander Boeck and can be sold under the trademark Pro-Jump.
WHAT ARE THE BENEFITS OF USING PRO-JUMPS? There are lots of advantages of using Pro-Jump stilts, some are listed below: >> Lots of FUN!>> Enables you to jump 6ft high>> Enables you to run 25mph+ >> Provides a cardio-vascular workout>> Aids weight loss and burns lots of calories>> Strengthens and tones the body's core muscles>> Lowers cholesterol levels>> And did I mention... Lots of FUN (has to be said twice because it really is!) HOW HARD IS POWERBOCKING?It may look difficult but its not! Generally it takes no longer than 30 min's to start walking on your own. Initially you may like to have a friend or wall handy just in case! Please visit www.ProJumpForum.co.uk for more start up tips and tutorials. HOW DO I CHOOSE THE CORRECT SIZE FOR ME?There is a handy chart and a full explanation on our forum. Please see hereWHERE CAN I SEE THE STILTS BEEN USED? Videos and pictures can be found on this site, on the ProJumpForum and on places like youtube. The stilts have also been featured on national tv click here to read more and see videos. They were seen on the BBC1 Jonathan Ross show where Brucie from the display team did a stage act using Pro-Jump branded stilts. Also Some Pro-Jumps were given away on the BBC2 Children's Smile TV show. Swebounce also performed on some Powerskip jumping stilts on graham nortons "When will I be famous?" show.BRANDS / TRADEMARKSOn this site we sell Pro-Jump / ProJump Jumping Stilts only.However there are other jumping stilt brands which are similar in design some names include :* Poweriser * Powerizer * Power Skips * Skyrunners * Fly Jumper * Flying Jumpers * Sky high boots * Velocity Stilts * Running Stilts * Rocket Shoes * Kangaroo Shoes * Bouncy Stilts * Street Jumpers * Speed Jumpers * 7Milesboots *Power Shoes * Pogo Stilts * Powerskippers * 7 leagues etc
© www. Pro-Jump.co.uk 2007. All Rights Reserved terms and conditions | site map | Contact Us | links Pro-Jump stilts are original patent protected jumping stilts, bouncing stilts, powerbocks. Similar stilts are aka Powerisers, Powerizers, PowerStrider, Jolly Jumper, 7 League boots, fly jumpers, powerskips. velocity stilts, skyrunners, poweriser, powerizer, 7mileboot, Olympic, Jolly jumpers. We only sell Pro-Jump.


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As I'm finding my voice as an artist (an ongoing process for life!) I'm looking back through old bodies of work. How did they come along? What was my intention? Where did they come from?
When I look at this particular volume from around 2010 I am very much aware of where I was at that time emotionally. I had just divorced my childrens Dad (for the second time) and we had moved back to my hometown Køge. The reason we got divorced was that I had found out that I am bisexual. Emotionally I was all over the place.
What a lot of people see in these paintings are penises. Maybe they are and maybe they're not. Who knows. To me though it was an exploration of a technique I saw Astrid Sylwan use on You Tube. And I was making mountains. (And a totem pole.) I love mountains. (And totem poles.) Maybe because Denmark is so flat. (And totem poles are cool.) Maybe as a symbol of my awareness about a future where I had to climb mountains. It's never really that simple when I paint. I paint from an emotional place. A state of mind. But it's never about just one thing.
A few of these were part of a series called 'going' and as I'm explaining on the screenshot below, from an old website update, it's all about intuition, analyzing and state of mind. In the text I also talk about reversing my routine. Working from a theme instead of looking back and discover it? That never happened! I don't really pick a theme and then go for it. It's more about what's going on in my life. Inside and outside. What interests me, what angers me etc. The difference from earlier on is that now I'm aware of where I am in the process.
I will admit to these two below being very sexual. You might not even agree. I went through a fase that I just had to go through I guess. And it kinda came out like this.
- breathe: suck blow puke
- serial masturbator: you would if you could
Below the left one is from around 2010 and the right one is from the other day. Do you see any similarities? Does it make a difference now that you've learned I'm bisexual? ;-)
The more recent body of work does have the occasional fallos symbol some might say. Which is why I say #itsnotadick.
And pink is back huh? I actually had a period where I didn't use pink much. What does pink mean? To me? To you? More on that in a later post...


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Armenia's Andranik Karapetyan was in second place of the men's 77-kilogram weightlifting competition when he suffered a horrific arm injury that left him screaming in pain.
He was attempting a 195kg clean and jerk, heaving the barbell over his head, when his left forearm appeared to snap back behind his head. Karapetyan stumbled off the stage in agony, and one of the trainers who rushed to help him could be seen holding his own head in his hands.
Karapetyan, who won the gold medal at the European Championships this year, had to withdraw.
U.S. & World
(Warning: Graphic video.)
Kazakhstan's Nijat Rahimov took gold in the competition, snatching the clean and jerk world record in the process.
Copyright AP - Associated Press


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You can't invent cases as strange as this: a book that is not only legal, but can be borrowed from various Australian libraries* can, in digital form, land the owner with a child porn conviction.
According to News's Hobart Mercury, David Traynor, an alderman in the Clarence council in Tasmania, was convicted for possessing child exploitation material when police found a copy of the 150-year-old book The Pearl stored on his council laptop (among a large number of pornographic but legal images).
The book is not only legal in Australia, but can be ordered from a host of bookshops and is even published as an ebook.
Even more mortifying for the alderman, the material was only reported to police after his laptop was stolen, then recovered, and finally (for reasons not explained in the story) handed over to a forensics expert who duly found deleted pornography.
While it's established that anybody who stores porn on a work computer is acting foolishly, the Tasmanian courts – or law-makers – may have found a new peak of prudishness to determine that material that's legal on paper is more menacing on a computer. Erotica fans would, it seems, do well to avoid buying it on Kindle or even, as Amazon offers, reading the first chapter online for free.
The alderman has been convicted and sentenced with a two-year good behaviour bond, and placed on Tasmania's sex offenders' register. He is launching an appeal. ®
*My thanks to the Twitterer @NetwonMark who identified the library catalogue entry. ®
Sponsored: Webcast: Ransomware has gone nuclear


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Translator tool provided for the benefit of our customers.
Please note English is used when calling to schedule a cab.
Yellow Cab
Prince William
24 Hours a Day
365 Days a Year
Today is Saturday, June 6, 2020
Please accept our apologies if the service you have received over the last week is less than you are used to. We are in the process of updating our phone and computer system and things rarely go as smoothly as we wish. Rest assured that we will be better for the upgrade and our service will return or exceed our previous level. Our new reservation link is up and working and our Booking App has been updated. Our new multi function IVR system that will allow you to book your cab with a push of a button on your phone. And the driver call out function should be up an running by the end of today at the latest!
CUSTOMER BEWARE We are not "Yellow Cab Services" We are Yellow Cab of Prince William. We have been Yellow Cab of Prince William for almost 40 years now. Daily we receive calls from unhappy passengers who want to know why we overcharged their credit card. It is almost always the same answer. We didn't! We are Yellow Cab of Prince William. Our cabs are yellow and white. They have back seat payment devices and meters. There is no franchise, just a small, local, family owned business. These unhappy customers, unfortunately, were taken for a ride and not the one they were hoping for. In most cases, we research the issue and find that an unlicensed, unpainted, probably underinsured FAKE picked them up. We have been battling this problem for quite sometime. These people use our name and the names of other reputable licensed companies and piggy back on our reputations to rip off the unsuspecting public. All taxis are not the same! Please make sure you call us (703-491-2222) and make sure you are getting in a legitimate, licensed, taxi! If you call this other company they will most likely refer their complaints to us and we will help you as much as we possibly can, but we can't refund money we didn't charge. We can only advise you that you have been ripped off and send you in a direction that may help you recover your money. Remember we are Yellow Cab of Prince William not Yellow Cab Services of Woodbridge or anywhere else.
No matter what the occasion, Yellow Cab of PWC is the solution
for all your transportation needs!
Yellow Cab of Prince William County serves the entire Northern Virginia area including all area airports. We service all local and long distance trips. We go where people go!! We are pleased to announce that we are now offering taxi service in North Stafford County VA. All drivers are independent contractors. Our dispatch center is fully computerized with state of the art customized dispatch software. All Yellow Cabs are equipped with the latest Android based tablets and two-way radios, allowing real time communication with drivers and dispatchers to ensure you the best and fastest service possible.
No matter what the occasion, Yellow Cab of PWC is the solution for all your transportation needs!
Award Winning Cab Company
- City of Manassas Outstanding Community Service
- Senator Charles J. Colgan Advocacy Award
- Prince William County Chamber of Commerce Innovative Practice/Partnership of the Year 2014
- Certificate of Appreciation - Freedom High School Air Force ROTC Program
- First Place Dumfries Christmas Parade (Vehicle Group/Motorized Unit)
Yellow Cab is a member of:
- Prince William Chamber of Commerce
- International Taxicab and Livery Association
- Virginia Taxi Association
- Fleetwatch of Prince William County (Fleetwatch is an association of companies that use two-way radios that notify police of problems the drivers may encounter on the road.)
Virginia Taxi Permit Number: #15064
Virginia Contract Passenger Number: #251
Certified as a woman owned small business by the Commonwealth of Virginia Department of Minority Business Enterprises.
We are a company that cares!


text:
Scoliosis is a problem with
the curve in your
spine. Some curves in your spine are normal. But a few
people have spines that make a
large curve from side to side in the shape of the letter "S" or the letter
"C." If this curve is severe, it can cause pain and make breathing
The good news is that most cases of scoliosis are
mild. If found early, they can usually be prevented from getting worse.
In most cases, the cause of
scoliosis is not known. Scoliosis usually starts
in childhood.
Scoliosis that is severe enough to need treatment is most common in girls.
A curve in the spine may
get worse as your child grows, so it is important to find any problem
Scoliosis most often causes
no symptoms in your child until the spinal curve becomes large. You might
notice these early signs:
In adults, scoliosis may cause back pain and trouble
The doctor will check
to see if your child's back or ribs are even. If the doctor finds that one side
is higher than the other, your child may need an X-ray so the spinal curve can
be measured.
Scoliosis is most serious in young children who are
still growing. A curve in the spine may get worse as your child grows.
So many experts believe screening your
child for scoliosis is important so that any curve in the spine can be found
early and watched closely.
Mild cases of scoliosis usually
do not need treatment. Your doctor will check the curve of your child's spine
every 4 to 6 months. If the curve gets worse, your child may need to wear a
brace until he or she has finished growing. In severe cases, or if bracing
doesn't help, your child may need to have surgery.
Scoliosis and
its treatment can be a severe strain on your child. Wearing a brace can feel
and look odd. It also limits your child's activity. Your child needs your
support and understanding to get through treatments successfully.
Your child
may be more likely to have scoliosis if someone in your family has had it and
if your child is a girl. Other things that increase the chance of scoliosis
Learning about scoliosis:
Being diagnosed:
Getting treatment:
Ongoing concerns:
Living with scoliosis:
Health Tools help you make wise health decisions or take action to improve your health.
In most cases, the cause of
scoliosis is not known. This is called idiopathic
scoliosis. It develops mostly in children and teens and appears to be related
to several things, including genetics, as it often runs in families.
There are two types of scoliosis: nonstructural and structural.
Nonstructural (functional) scoliosis involves a curve in the
spine, without rotation, that is reversible because it is caused by a condition such as:
Structural scoliosis involves a
curve in the spine, with rotation, that is irreversible and is usually caused
by an unknown factor (idiopathic) or a disease or condition such as:
In adults, scoliosis may result from changes in the spine
due to aging (degenerative changes). These degenerative changes may be caused
In children and teens,
scoliosis typically does not cause symptoms and is not
obvious until the curve of the spine becomes moderate or severe. It may first become
noticeable to a parent who observes that the child's clothes do not fit right
or that hems hang unevenly. The child's spine may look crooked, or the ribs may
stick out.
In a child who has scoliosis:
Most of the time scoliosis does not cause pain in children
or teens. When back pain is present with
scoliosis, it may be because the curve in the spine is causing stress and pressure on the spinal discs, nerves, muscles, ligaments, or facet joints. It is not usually caused by
the curve itself. Pain in a teen who has scoliosis may indicate another problem, such
as a bone or spinal tumor. If your child has pain associated with scoliosis, it
is very important that he or she see a doctor to find out what is causing the
Adults who have scoliosis may or may not have back pain. In
most cases where back pain is present, it is hard to know whether scoliosis is
the cause. But if scoliosis in an adult gets worse and becomes severe, it
can cause back pain and difficulty breathing.
other conditions, such as
kyphosis, cause symptoms similar to scoliosis.
Idiopathic scoliosis, the most
common type, does not have a known cause. Children who have this type of
scoliosis usually first develop symptoms in childhood.
Most cases of scoliosis are mild, involving small curves in the spine that do
not get worse. Small curves usually do not cause pain or other problems.
Usually a doctor examines the child every 4 to 6 months to watch for any
In moderate or severe cases of scoliosis, the curves
continue to get worse. During periods of growth, such as during the teenage
growth spurt, the curves may get worse. Mild to moderate curves often
stop progressing when the skeleton stops growing, while larger curves may get
worse throughout adulthood unless they are treated.
Only about
1 out of 10 children who are diagnosed with scoliosis require treatment (either
bracing or surgery).1
Things that may
point to the potential increase in a spinal curve include:
Girls are more likely than boys to have larger curves and
more severe scoliosis.
As scoliosis gets worse, the bones of the
spine rotate toward the inner part of the curve. If the upper part of the spine
is affected, the ribs may crowd together on one side of the body and become
widely separated on the other side. The curve may force the space between the
spinal bones to narrow. The spinal bones may also become thicker on the outer
edge of the curve.
In severe curves, misshapen ribs may reduce the
amount of air the lungs can hold and may cause the heart to work harder to pump
blood through the compressed lung tissue. Over time, this can lead to
heart failure.
Although it is uncommon,
babies can be born with scoliosis (congenital) or can develop it during the
first 3 years of their lives (infantile scoliosis). Scoliosis that is present
at birth or that develops in infants may be worse in the long run than
scoliosis that develops later in life. This is because the more growing the
skeleton has to do, the worse the curve may get. But in some cases
congenital curves do not get worse. And some curves that are present during
infancy get better on their own without treatment.
Things that increase a
person's risk for
scoliosis include:
Scoliosis is more common in people who have:
Call your doctor to
have your child evaluated for
scoliosis if:
If you suspect that your child has a spinal
curve, ask a health professional to look at it, either through a school
screening program or during a doctor visit. Early detection could lead to early
treatment and could prevent a curve from getting worse.
If the
results of a school screening program suggest that your child may have a spinal
curve, follow up with your doctor. Most curves that are found through school
screening programs are normal variations in the spine or mild scoliosis, and
these curves usually require only regular observation.
The following health professionals could identify and
monitor scoliosis:
A doctor who specializes in surgery of the bones (orthopedic surgeon) may be consulted if the person has
a large curve. The orthopedic surgeon will evaluate the curve and may recommend
bracing or surgery.
A health professional who fits people with
specially designed assistive devices (orthotist) can build and fit a custom
To prepare for your appointment, see the topic Making the Most of Your Appointment.
testing usually begins with a
history and physical exam. This includes the
forward-bending test, a simple test in which the child bends forward at the
waist, arms hanging loosely and palms touching, and the examiner looks for
unevenness in the child's back or ribs. A
scoliometer can be used to measure and estimate the
rotation of the spinal curve.
If the findings of the history and
physical exam show a significant spinal curve, an
X-ray of the spine may be taken to get a more precise
measurement of the spinal curve.
Skeletal age, as determined by
the Risser sign, is also a helpful measure to find out
the risk that the curve will get worse.
If someone in your family
has scoliosis, your children should be checked regularly.
Neurological testing may be done on children who have scoliosis to
see if they have certain disorders that are often associated with
scoliosis, such as
cerebral palsy or
muscular dystrophy.
Screening means doing a
simple test to see whether further testing might be needed.
Some states require screening for scoliosis by law.
But experts don't agree with whether or not to screen for scoliosis.3, 4 Screening can lead to early treatment and may prevent curves from getting worse, but screening can also lead to more testing or treatment for children who would not have needed it.
Some experts believe that children (especially daughters) of women who have scoliosis should be screened for scoliosis regularly throughout their late
childhood and teen years.2
If you are concerned about screening for scoliosis, talk to your child's doctor.
The goal of treatment for
scoliosis is to prevent the spinal curve from getting
worse and to correct or stabilize a severe spinal curve. Fortunately, few people who have spinal curves require treatment.
The type of treatment depends on the cause of
scoliosis. Scoliosis that is caused by another condition (nonstructural
scoliosis) usually improves when the condition, such as muscle
spasms or a difference in leg length, is treated. Scoliosis that is caused by a
disease or by an unknown factor (structural scoliosis) is more likely than nonstructural scoliosis to need
Treatment is based on the age of the person, the size
of the curve, and the risk of progression. The risk of progression is based on
age at diagnosis, the size of the curve (as measured using
X-rays of the spine), and skeletal age (which can be
determined by the
Risser sign).
Most cases of scoliosis are mild
and do not require treatment.
The timing of surgery for scoliosis
in children is controversial. Spinal fusion stops the growth of the fused part of the spine,
so some experts believe that surgery should be
delayed until the child is at least 10 years old and preferably 12. But even after surgery the
rest of the spine will continue to grow normally in children who are still
cannot be prevented. Treatment is aimed at preventing the curve from getting
If your child or teen has been
diagnosed with mild
scoliosis, it is important that a doctor check the child's spine every 4 to 6
months to see whether the curve is getting worse. Most spinal
curves do not progress to the point where treatment is needed. But it is
important to check for curve progression, because early treatment can often stop
for moderate or severe scoliosis can dramatically impact your child's life. If
your child has scoliosis, it is important that your family be sensitive to the
difficulty of having scoliosis and
wearing a brace. A scoliosis clinic, where other
children are being treated, can provide a supportive environment for your
Adults who have scoliosis may
have back pain. In addition to medicine, other steps that help to maintain or
promote good health, such as regular exercise and proper back care, may help
relieve back pain for some adults.
When back pain is present with
scoliosis, it may be that the curve in the spine is causing stress and pressure on the spinal discs, nerves, muscles, ligaments, or facet joints. It is not usually caused by
the curve itself. Some people may use nonprescription medicines such as aspirin
and ibuprofen to treat back pain. While these medicines may relieve symptoms of
back pain temporarily, they do not heal scoliosis or back injuries, nor do they
stop the pain from coming back.
Surgery may be used to treat severe
scoliosis. The goal of surgery is to improve a severe
spinal curve. The result will not be a perfectly straight spine, but the goal
is to balance the spine and to make sure the curve does not get worse. Surgery
usually involves stabilizing the spine and keeping the curve from getting worse
by permanently joining the vertebrae together.
Things that are
considered before surgery include:
Surgery may be considered if:
The main type of surgery for scoliosis involves attaching
rods to the spine and doing a
spinal fusion. Spinal fusion is used to stabilize and reduce
the size of the curve and stop the curve from getting worse by permanently
joining the vertebrae into a solid mass of bone.
Other techniques
are sometimes used, including
instrumentation without fusion, which
attaches devices such as metal rods to the spine to stabilize a spinal curve
without fusing the spine together. This is only done in very young
children when a fusion, which stops the growth of the fused part of the spine,
is not desirable. The child usually has to wear a brace full-time after having
this surgery.
Surgical treatment in children and teens usually requires
several days in the hospital and limitations on activity for approximately a
year. In adults, the average hospital stay is longer.
Adults who
have surgery for scoliosis that results from changes in the spine due to aging
(degenerative scoliosis) are more likely than children to have significant
complications. Even though surgery usually reduces their pain, other
complications may occur, such as
pseudoarthrosis and wound infections.
Treatment other than surgery
scoliosis includes:
There is no evidence that corrective exercises, electrical
stimulation, or spinal manipulation are effective treatments for
The American Academy of Orthopaedic Surgeons (AAOS)
provides information and education to raise the public's awareness of
musculoskeletal conditions, with an emphasis on preventive measures. The AAOS
website contains information on orthopedic conditions and treatments, injury
prevention, and wellness and exercise.
This website is sponsored by the Nemours Foundation. It
has a wide range of information about children's health—from allergies and
diseases to normal growth and development (birth to adolescence). This website
offers separate areas for kids, teens, and parents, each providing
age-appropriate information that the child or parent can understand. You can
sign up to get weekly emails about your area of interest.
The National Institute of Arthritis and Musculoskeletal
and Skin Diseases (NIAMS) is a governmental institute that serves the public
and health professionals by providing information, locating other information
sources, and participating in a national federal database of health
information. NIAMS supports research into the causes, treatment, and prevention
of arthritis and musculoskeletal and skin diseases and supports the training of
scientists to carry out this research.
The NIAMS website provides
health information referrals to the NIAMS Clearinghouse, which has information
packages about diseases.
The Scoliosis Research Society (SRS) fosters optimal
care for people with any disorder that may affect the shape, alignment, or
function of the spine. The SRS accomplishes this through
education, research, advocacy, and ethical practice.
CitationsStaheli LT (2006). Scoliosis section of Spine and pelvis. In Practice of Pediatric Orthopedics, pp. 210–219. Philadelphia: Lippincott Williams and Wilkins.Hu SS, et al. (2006). Scoliosis section of Disorders, diseases and injuries of the spine. In HB Skinner, ed., Current Diagnosis and Treatment in Orthopedics, 4th ed., chap. 5, pp. 255–269. New York: Lange Medical/McGraw-Hill.U.S. Preventive Services Task Force (2004). Screening for idiopathic scoliosis in adolescents: Recommendation statement. Rockville, MD: Agency for Healthcare Research and Quality (AHRQ). Available online: http://www.uspreventiveservicestaskforce.org/uspstf/uspsaisc.htm.Richards BS, Vitale M (2007). SRS/AAOS Position statement: Screening for idiopathic scoliosis in adolescents. An information statement. Available online: http://www.aaos.org/about/papers/position/1122.asp.Other Works ConsultedAmerican Academy of Orthopaedic Surgeons and American
Academy of Pediatrics (2010). Scoliosis. In JF
Sarwark, ed., Essentials of Musculoskeletal Care, 4th ed., pp. 1164–1169.
Rosemont, IL: American Academy of Orthopaedic Surgeons.Negrini S, et al. (2010). Braces for idiopathic scoliosis in adolescents (Review). Cochrane Database of Systematic Reviews (1).Polousky JD (2011). Orthopedics. In WW Hay Jr et al., eds., Current Diagnosis and Treatment: Pediatrics, 20th ed., chap. 24, pp. 778–795. New York: McGraw-Hill.Rowe DE (2003). The Scoliosis Research Society Brace Manual. Available online: http://www.srs.org/professionals/education_materials/SRS_bracing_manual/section1.pdf.Weinstein SL, et al. (2003). Health and function of patients with untreated idiopathic scoliosis: A 50-year natural history study. JAMA, 289(5): 559–567.Yawn BP, et al. (1999). A population-based study of school scoliosis screening. JAMA, 282(15): 1427–1432.
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Last Revised:
July 21, 2011
Healthwise Staff
Medical Review:
John Pope, MD - Pediatrics & Robert B. Keller, MD - Orthopedics
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text: Terms and Conditions as published on the Website are in English and it is the English version of these Terms and Conditions that form the basis of these Terms and Conditions only. Translations into other languages may be made as a service and in good faith. However, in the event of ambiguity between the English version and a translation, the English version has priority over any translation.


text:
By the way, my TBS 3.75" find was in a smaller Walmart where they had the TBS absent on planograms... Meaning it seems that, at least some cases anyway, some of that WM planogram panic was unfounded or a little premature.
I'm only tempted by Padme - maybe - and I've yet to see her. Once I see her and have her in hand, I'll decided. Otherwise, it's mostly pass for me on this wave.
Page created in 0.07 seconds with 18 queries.


text:
Welcome to McConnell Funeral Home On-Line
We are a family-owned company located in the villages of Tweed, Madoc and Marmora and have been providing funeral service to the Hastings, Central Hastings, North Hastings, Lennox and Addington, and East Peterborough Counties for over 48 years. It is our hope that you will find this site useful and informative. You will be able to view current funeral information, send on-line condolences, make requests for funeral information, products and costs, access information regarding the industry and local florists. If you don't find what you are looking for, let us know. It is our ambition to make this site useful and a beneficial addition to our service.


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WebBeans in Glassfish (0 messages)
Web Beans is a technology that integrates both JSF and EJB3, allowing an EJB3 session bean to act as a JSF managed bean. In this post Cay Horstmann explains two features that are crucial for JSF users using WebBeans: Conversation scope and access to stateful session beans from JSF pages; all in the context of Glassfish. Read Cay Horstmann's entire post 'WebBeans in Glassfish v3': http://weblogs.java.net/blog/cayhorstmann/archive/2009/07/webbeans_in_gla.html
- Posted by: Daniel Rubio
- Posted on: July 06 2009 11:13 EDT


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[744x1392] [852x1608]
[1600x1200] [2560x1440]
Sundogs are an optical phenomenon in which a pair of mock suns appear on either side of the sun. These spots form along a halo that appears to encircle the sun. This is an optical phenomenon caused by the refraction of sunlight on flat, hexagonal ice crystals (or diamond dust) found high in the sky in cirrus clouds. When the hexagonal ice crystals are randomly oriented, a halo is observed. In cases where the hexagonal ice crystals are oriented with their flat faces horizontally, sundogs are also observed. This is why halos are seen more often than sundogs. These same bright spots can occur around the moon. Moondogs can appear in a lunar halo, but requires the bright light of either a full moon or nearly-full moon.
Click on the posters below to learn more about the conditions and to download free high-res print and postcard files!


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Saving you £100.00 (41%)
Taking you back to the good old days, with all the modern technology, these Viking Heritage bikes are the best value for money retro range out there.
Pastel colours, colour coded accessories, with baskets, mudguards and carriers as standard, these bikes bring fashion to every bike ride.
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Free delivery on the Viking Crystal 26 bike with basket to most of the UK.
More stock arriving
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Please use the yellow "Pre-Order NOW" button to reserve your bike.
We will email you as soon as your bike is despatched.


text:
Having had its PlayStation 3 outing spoiled by a Korean classification rating, Limbo is now also making its way to the personal computer as well.
"Limbo is production for Steam and PSN, and is coming very soon," Dino Patti, CEO of developers Playdead, told Edge. "I can't elaborate more at this moment, but we will have more details soon."
Excellent news! The more people that get to play this game, the better. You can check out our review of the game here.


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UNIVERSITY OF WISCONSIN River Falls
The Student Success Center at UW-River Falls is home to a number of programs and services with one common goal—your success. We understand that your definition of success might be very different from someone else's definition of success, which is why we strive to provide a variety of opportunities allowing you to participate in those that align closely with your personal academic goals.We welcome you to stop in or give us a call if you are interested in learning more about the free programs and services offered in the UW-River Falls Student Success Center.
Declaring your major is a big decision, and we're here to help. The Pre-Major/Exploratory Advising Program is designed to assist exploratory students who are undecided about their academic pathway. Program participants will work on completing their general education requirements while exploring a variety of academic options and outcomes. By the end of your freshman year, you'll know more about yourself and be prepared to declare your major with confidence.
Jessica Wekkin | 715-425-3521 | firstname.lastname@example.com
Student Support Services (SSS) Program at UW-River Falls offers a number of educational outreach and enrichment opportunities to maximize your academic success at the college level. Program participants receive access to one-on-one academic coaching, leadership and community service opportunities, career/graduate school advising, opportunities to participate in social/cultural activities, and assistance with accessing campus services.To be eligible for this federally funded TRiO program, you must meet one of the following criteria: (1) first-generation college student (parent/guardian did not receive a bachelor's degree), (2) financial need (see Go.uwrf.edu/SSS for income guidelines) or (3) have a documented disability.
Tutoring Services provides free, unlimited tutoring to all students. You have the choice of scheduling a private appointment with a specific tutor, or taking advantage of a tutoring center that operates on a drop-in basis.
For instructions on scheduling a private tutoring appointment, visit:
For operating hours for the drop-in tutoring centers listed below, visit:
Kelly Grenzow | 715-425-3531 | email@example.com
If you have any compliments, suggestions, information, or concerns about the Student Success Center, please let us know using this process.


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Hey Ozzie, we're out of it now:
Don't look for a September callup such as Tyler Flowers to get regular at-bats any time in the near future for the White Sox. Although Flowers is considered a rising star in the organization and a top prospect, playing the young catcher is not the best way for the White Sox to keep their fledgling playoff hopes alive. And manager Ozzie Guillen believes those playoffs hopes still exist. "If I do that, then I give up, and I'm not going to give up," said Guillen of going extremely young within his lineup during the final month. "I don't care. If they give up, that's their problem. I never will give up. When we are out, then we play the kids. I hope I don't have to play them. But when we get to that point, we will play the kids."


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This week we talked about fabrics we love, designers and fabric houses and a little bit about how we use them!
And in our chat on blogging, we talked about technical issues like how we upload photos, what applications are available to help us write and format posts and pics and other little tidbits. There's always something to learn.
As always, thanks for stopping by and for all your kind comments and emails!


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Pocket Artillery
Remember that tiny cannon you could fit in your hand? Now you can own your very own, and fire tiny but destructive BBs across the room. pre-order here – link
Dare to Fight?
If you come across a ninja with a sign in front of him daring you to engage him in combat and even giving you a weapon to use, remember two things: 1. Ninjas are sneaky. 2. Bring coffee.
Branding 10 000 Lakes
An initiative by the designer Nicole Meyer based in Minneapolis, thinking the logos of over 10,000 lakes, which used to be very traditional.
Artisanal Ansatz
Artisanal Ansatz is an art collective made up of a small group of Belgian designers that cite surrealism and caricature as chief influences. The group creates tee shirts with popular cultural staples like pop star Lady Gaga, Hip-Hop God Ol' Dirty Bastard and filmaker Quentin Tarantino among others. Remarkably, all of the designs that end up on their tee shirts are done with a very unlikely and archaic instrument – the ball point pen.
Marble Manhattan
Artist Yukata Sone turned a village of Chinese artisans into urban topographers carving New York City out of marble.
Originally trained as an architect and with a natural bent toward obsessing over details, Sone started working in marble and twelve years ago discovered the traditional stone carvers in the tiny Chinese village of Chongwu. The carvers were mostly engaged in making stone dragons, lanterns, and Buddhas using age-old craft techniques. He asked a group to work with him on carving more dynamic shapes such as machinery and urban landscapes
Toyota Hilux – Tougher Than You Can Imagine
Toyota's commercial for the 2012 Hilux is a hyperbolic romp through New Zealand that will make you want to get a Hilux and/or live in New Zealand.
Toyota Hilux Australia Unbreakable
1965 Ford Mustang Wagon
A 1965 Ford Mustang Shooting Break can be bought from anAmerican showroom for nearly 50,000 euros.
Ford Mustang, one of the most famous and valued representatives of the muscle car kingdom seems to have always one surprise. In the videos below you will get acquainted with the shooting brake version of a custom-build 1965 Mustang.


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No-Limit Engineering - Classic Life
Off-The-Shelf Or One-Off
In the same way it's been fashionable in recent years to add the word "choppers" to the end of a motorcycle shop's name there was a trend in the late 20th century to add "engineering" to the end of just about any kind of shop's name. Looking back one might think gee, there sure use to be a lot of engineers back then, but the truth of it was few shops had any real engineers in their employ.
In 1984 when Rob MacGregor opened the doors to No-Limit Engineering he had just graduated from Cal Poly Pomona as an engineer. Rob had a '56 Chevy pickup, that he still owns to this day, that has served as a testbed dating back to its use as his daily-driver back and forth to college. With a hot-rod motor under the hood the '56 got up and went, but it was a little light in the brakes and suspension department. There were more than a few times when the beefed-up stock components left Rob with white knuckles. Beyond not really being able to stop, Rob discovered there were some serious reliability issues. One time on a little jaunt from San Bernardino, California, to Calgary, Alberta, Canada, Rob got a firsthand look at what happens to stock Chevy ball-type wheel bearings after miles of extended high-speed use. These were the early days, and a lot of things have changed since then. As the years passed, Rob and his crew gained a lot of firsthand knowledge as they developed custom parts to be sold on a production basis, and custom-engineered parts for serious one-off customs built to compete on the show-and-go circuit.
Recently, we dropped in out of the blue to see what Rob and the crew at No-Limit Engineering have been up to.


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Chris Brown certainly has interesting timing.
Just days after deleting his profile following a series of juvenile tweets he sent a female comic who bashed Breezy for his beatdown of Rihanna, the 23-year-old Brown is now gracing the cover of the December/January issue of XXL in which he touted his brand-new ability to, um, not lose his composure on Twitter.
"I haven't been as mature and thought out in the past, so, me growing now, it's showing my progression," Brown told the magazine regarding his excursions on social media.
U.S. & World
The day's top national and international news.
Chris Brown shuts down Twitter page following feud with comedian
He elaborated: "I used to use my Twitter account to vent, but now I mostly use it for marketing and promotions. Even if the media asks me something, if it's cool then it's 'What's up?' But if it's anything that's too negative, I don't care to respond."
Of course, the sit-down occurred before the "Run It" singer got into his Twitter feud with comedy writer Jenny Johnson, not to mention before he raised eyebrows with his various Twitter exchanges with Rihanna, as Ri-Ri posted intimate Instagram pics of her and her ex-beau while at the same time denying reports the two have renewed their romance (also fueled by various joint nightclub appearances).
Brown also attempts to set the record straight about the women in his life as well.
Rihanna tweets photo of Chris Brown in bed
"One thing people often want me to talk about is my public love life. When it comes to my love life, the perception seems as though I am a player," he added. "But that's not true. Love is something I am still learning. It's just an obstacle that I haven't yet mastered. I think that's my biggest hurdle in life."
He can probably add keeping his cool on Twitter to that.


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Underground have a famous Any Deck + Any Truck + Any Wheel Combo for $259.99 This have a max retail value of $310 and excludes bearings and bolts.
If you would like this deal please email the links to the items you want to email@example.com and we can sort this deal out for you manually. Or add items to the cart and screenshot and email.


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By Gurudev Kaur/Elizabeth Carovillano
With all that is happening in the tragic displays of fear and pain in our communities, I have felt so compelled to meditate and chant Ra Ma Da Sa Sa Say So Hung. Chanting settles my heart and mind while invoking the pure power to heal and bless. We are all powerful healers and have the potential, through our intentions and prayers, to spread healing and light where it is needed most.
I find myself mentally chanting this throughout the day or whispering it as I go about my work. It is so soothing and pure. May our collective vision of light and love bring healing to the the darkness and pain.
Ra Ma Da Sa Healing Meditation
Posture: Sit in easy pose with your legs crossed and spine straight, or sit in a chair with feet flat on the floor.
Mudra: Bend the arms and bring the elbows against the side of the rib cage. The palms of the hands face the sky. The elbows are snug at your sides with the forearms in close to your upper arms. The hands are at a 45 degree angle, halfway between pointing forward and pointing to the sides.
Focus: Eyes are closed and focused at the third-eye point.
Mantra: Ra Ma Da Sa, Sa Say So Hung. The mantra should be sung in one complete exhalation. As you chant the first Sa, your navel point is pulled in so that this syllable is abbreviated. You should also pull your navel point in as you chant Hung. Hung should be vibrated at the root of the nose. The rest of the syllables are drawn out in a strong, powerful chant. Strive to keep your chant at full volume (loud but not raucous) throughout the meditation.
Ra = sun energy
Ma = moon energy
Da = earth energy
Sa = infinity, universal energy
Sa (repeated)
Say = the personal embodiment of Sa
So = the personal sense of merger with Sa
Hung = the Infinite, vibrating and real
This mantra literally means: "I am Thou." It can also mean, "the service of God is within me."
Time: 11 minutes.
End: Inhale deeply, hold your breath and visualize the person you want to send healing to (it can be yourself). Make that image in your mind very clear and see a glowing green light around the person. Keeping that person in your mind, exhale. Inhale deeply, hold your breath and continue to send the person healing green light. Still keeping that vision in your mind, exhale. For the last time, inhale deeply, hold your breath and see the person very clearly, see the green healing light bathing the person, bathing every cell in the body.
Exhale and relax.
© The Teachings of Yogi Bhajan
See also: Ra Ma Da Sa Sa Say So Hung
Go to Spirit Voyage to listen to or purchase a download of the Ra Ma Da Sa Sa Say So Hung Chant--beautifully recorded by several different artists.