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PEG-Interferon a-2b + Ribavirin for Treatment of Chronic HRN 005 Hepatitis C Infection in HIV-Infected Persons Not Previously Treated With Interferon
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00215891
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : October 25, 2005
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Primary To compare the sustained virologic response (SVR) of PEGIntron plus ribavirin among patients receiving 48 weeks versus 72 weeks of therapy (defined as undetectable HCV RNA level 24 weeks after discontinuing therapy).
- To evaluate the safety and tolerability PEG Intron in combination with ribavirin for treatment of Chronic Hepatitis C (CHC) infection in patients co-infected with Human Immunodeficiency Virus (HIV).
- To determine the early virologic response of patients receiving PEGIntron plus ribavirin at Treatment Week 24
Study Design:
All qualifying patients will enter the treatment phase and be dosed as follows:
Peginterferon a-2b 1.5mg/kg by subcutaneous route once weekly plus
- 800 mg (400 mg bid) if body weight < 65 kg
- 1000 mg (400 mg a.m. and 600 mg p.m.) if body weight > 65 kg and < 85 kg
- 1200 mg (600 mg bid) if body weight > 85 kg and < 105 kg
- 1400 mg (600 mg a.m. and 800 mg p.m.) if body weight > 105 kg
At Treatment Week 24, all participants with detectable HCV-RNA will be discontinued from treatment and followed for a Post Treatment period of 24 weeks. Participants with undetectable HCV-RNA values at Treatment Week 24 will be randomized to either:
- Group A: an additional 24 weeks of previously assigned Peginterferon a-2b + Ribavirin therapy, for a total of 48 weeks of treatment.
- Group B: an additional 48 weeks of previously assigned Peginterferon a-2b + Ribavirin therapy, for a total of 72 weeks of treatment.
Study Population:
300 HIV infected adults with chronic hepatitis C infection who have not been treated previously with interferon therapy.
Dosage and Administration:
Peginterferon a-2b 1.5mg/kg by subcutaneous route once weekly plus
- 800 mg (400 mg bid) if body weight < 65 kg
- 1000 mg (400 mg a.m. and 600 mg p.m.) if body weight > 65 kg and < 85 kg
- 1200 mg (600 mg bid) if body weight > 85 kg and < 105 kg
- 1400 mg (600 mg a.m. and 800 mg p.m.) if body weight > 105 kg
Efficacy Evaluations:
Laboratory analysis, liver biopsies, quality of life assessments, and changes in Peginterferona-2b and Ribavirin dosages will be obtained.
Safety Evaluations:
- Assessment of laboratory evaluations
- vital signs
- incidence and severity of adverse experiences
- dose adjustments
- premature withdrawal for safety reasons
- progression of disease as measured by HCV viral load
- AIDS defining events
|Condition or disease
|Chronic Hepatitis C Infection in HIV-Infected Persons HIV Infections
|Drug: PEG-Interferon a-2b + Ribavirin
|Phase 3
|Study Type :
|Interventional (Clinical Trial)
|Enrollment :
|300 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|PEG-Interferon a-2b + Ribavirin for Treatment of Chronic Hepatitis C Infection in HIV-Infected Persons Not Previously Treated With Interferon
- Objectives:
- Primary
- To compare the sustained virologic response (SVR) of PEGIntron plus ribavirin among patients receiving 48 weeks versus 72 weeks of therapy (defined as undetectable HCV RNA level 24 weeks after discontinuing therapy).
- Secondary
- · To evaluate the safety and tolerability PEG Intron in combination with ribavirin for treatment of Chronic Hepatitis C (CHC) infection in patients co-infected with Human Immunodeficiency Virus (HIV).
- · To determine the early virologic response of patients receiving PEGIntron plus ribavirin at Treatment Week 24
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
5.2 Inclusion Criteria
To be eligible for this trial, patients must have documentation of the following:
5.2.1 Written informed consent specific to this protocol obtained prior to screening and willingness to participate in and comply with the study.
5.2.2 Male and female patients >18 years of age.
5.2.3 Detectable plasma HCV-RNA by RT-PCR or other assay (bDNA).
5.2.4 HCV genotype result must be available at screening (historical determinations of genotype are acceptable).
5.2.5 Evidence of HIV infection (reactive HIV antibody with Western blot confirmation).
5.2.6 Compensated liver disease with the following laboratory parameters at screening (results within 1 month of screening):
- Hemoglobin values of ³ 11 gm/dL
- WBC ³ 3,000/mm3
- Neutrophil count ³1,250/mm3
- Platelets ³ 70,000/mm3
- Prothrombin time £ 3 seconds prolonged compared to control, or equivalent INR ratio
- Bilirubin within 20% of the upper limit of normal (unless non-hepatitis related factors such as Gilbert's disease or the use of indinivir explains an indirect bilirubin rise).
- Albumin ³ 3.0 g/dL
- Serum creatinine £ 1.4 mg/dL
- Fasting blood sugar £ 115 mg/dL for non-diabetic patients
- Hemoglobin A1C £ 8.5% for diabetic patients (whether on medication and/or diet controlled)
5.2.7 Thyroid Stimulating Hormone (TSH) within normal limits or thyroid disease under clinical control (within 3 months of screening)
5.2.8 Alpha-fetoprotein (AFP) value within normal limits obtained within the prior year. For patients with results above the upper limit of normal but < 100 ng/mL both of the following are required:
- Alpha-fetoprotein value < 100 ng/mL obtained within 3 months prior to entry AND
- Ultrasound obtained within 3 months prior to entry that is negative for evidence of hepatocellular carcinoma.
5.2.9 CD4 T cell count and HIV RNA level (by RT-PCR) within 1 month of screening:
- CD4 <100 Eligible with HIV RNA <25,000 by RT-PCR
- CD4 > 100 - Eligible with any HIV RNA level by RT-PCR
5.2.10 Stable antiretroviral regimen of FDA-approved agents for at least 4 weeks prior to baseline.
5.2.11 Reconfirmation and documentation that all sexually active female patients of childbearing potential are practicing adequate contraception (intrauterine device, oral contraceptives, progesterone implanted rods [Norplant], medroxyprogesterone acetate [Depo-Provera], surgical sterilization, barrier method [diaphragm + spermicide], or monogamous relationship with a male partner who has had a vasectomy or is using a condom + spermicide) during the treatment period and for 6 months after discontinuation of therapy. Female patients must not breast feed during the treatment period and for 6 months after discontinuation of therapy. A urine pregnancy test obtained at entry prior to the initiation of treatment must be negative.
5.2.12 Reconfirmation and documentation that sexually active male patients are practicing acceptable methods of contraception (vasectomy, use of a condom + spermicide, monogamous relationship with a female partner who practices an acceptable method of contraception) during the treatment period and for 6 months after discontinuation of therapy.
5.2.13 Anyone at high risk of coronary artery disease should have a stress test performed prior to entry. This would include, but not be limited to, patients over age 55 who have a history of ischemia or who have a significant history of hypertension, diabetes mellitus, obesity, smoking and/or strong family history of coronary artery disease. Patients with evidence of ischemia on resting or stress EKG, or a history of an arrhythmia, angina or a myocardial infarction within 12 months must be excluded.
5.2.14 Although recommended, liver biopsy is not required for study entry. However, if a liver biopsy has been obtained, within three years of the initial screening visit, the pathology report will be collected with other study data.
Exclusion Criteria:
5.3 Exclusion Criteria
Patients meeting any of the following criteria are not eligible for this trial:
5.3.1 Inability or unwillingness to provide written informed consent specific to this protocol or unwillingness to participate in and comply with the study.
5.3.2 Previous therapy with interferon alfa.
5.3.3 Women with ongoing pregnancy or breast-feeding.
5.3.4 Male partners of women who are pregnant.
5.3.5 Hypersensitivity to interferon or ribavirin.
5.3.6 Evidence of advanced liver disease such as a history of or presence of ascites, bleeding varices, or spontaneous encephalopathy.
5.3.7 Any other causes for chronic liver disease other than chronic hepatitis C.
5.3.8 Hemoglobinopathies (e.g., Thalassemia) or any other cause of hemolytic anemia.
5.3.9 Any known preexisting medical condition that could interfere with a patient's participation in the protocol including: CNS trauma or active seizure disorders requiring medication; poorly controlled diabetes mellitus; serious pulmonary disease; immunologically-mediated diseases; gout; or any medical condition requiring, or likely to require during the course of the study, chronic systemic administration of steroids.
5.3.10 Patients with evidence of ischemia upon stress testing (required for patients at risk of or with a history of coronary artery disease, ECG evidence of ischemia, an arrhythmia, cardiac failure, coronary surgery, uncontrolled hypertension, angina or a myocardial infarction within 12 months).
5.3.11 Active or acute HIV-related opportunistic infection.
5.3.12 Evidence of severe retinopathy (e.g. CMV retinitis, macular degeneration)
5.3.13 History of major organ transplantation with an existing functional graft (including Bone Marrow Transplants)
5.3.14 History of any systemic anti-neoplastic or immunomodulatory treatment (including supraphysiologic doses of steroids and radiation) £6 months prior to the first dose of study drug or the expectation that such treatment will be needed at any time during the study.
5.3.15 Concomitant medication with, rifampin/rifampicin, rifabutin, pyrazinamide, isoniazid, ganciclovir, thalidomide, oxymetholone (Anadrolâ), and immunomodulatory treatments (including supraphysiologic doses of steroids).
5.3.16 Coadministration of didanosine (DDI, dideoxyadenosine 5'-triphosphate) and ribavirin is not recommended.
5.3.17 Evidence of alcohol and/or drug abuse within one year of entry. Patients on methadone programs are not excluded.
5.3.18 Inability to abstain from alcohol throughout the entire course of treatment and follow-up.
5.3.19 History of severe psychiatric disease, especially depression. Severe psychiatric disease is defined as treatment with an antidepressant medication or a major tranquilizer at therapeutic doses for major depression or psychosis, respectively, for at least 3 months at any previous time or any history of the following: a suicidal attempt, hospitalization for psychiatric disease, or a period of disability due to a psychiatric disease.
5.3.20 History or other evidence of severe illness or any other conditions which would make the patient, in the opinion of the investigator, unsuitable for the study.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00215891
|United States, Maryland
|Johns Hopkins University School of Medicine
|Baltimore, Maryland, United States, 21231-1001
|Principal Investigator:
|Mark Sulkowski, MD
|Hepatitis Resource Network
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|September 22, 2005 Key Record Dates
|Last Update Posted:
|October 25, 2005
|Last Verified:
|September 2005
Treatment Experienced
Communicable Diseases
Hepatitis A
Hepatitis C
Hepatitis C, Chronic
Hepatitis, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Flaviviridae Infections
Antineoplastic Agents
Antiviral Agents
Anti-Infective Agents
Molecular Mechanisms of Pharmacological Action


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All-New Ford 9-Inch Upgrade
As the Supply of Used Rearends Dwindles, Currie Offers a Stronger Alternative
The days of going to your local wrecking yard and picking up a good Ford 9-inch rearend for your hot rod project are coming to an end. That sturdy and versatile unit was last produced for passenger cars in 1981 and in pickup trucks in 1986. Considering that 9-inchers are the most used rearends in nearly every form of racing and most high-performance street vehicles, it's not hard to see why they are becoming scarce commodities.
Even when you do find one, you have to determine whether the tubes are straight or the axles bent. When you figure in the time that it takes to refurbish an old rusty hulk and transform it into a usable unit for your rod, you might wonder if there's a better way to find a rearend. One answer would be to use a 9+ rearend from Currie Enterprises.
Despite the dwindling supply of salvaged 9-inch rearends, Currie's main business is remanufacturing them for hot rods, race cars and off-road vehicles. The company refurbishes more than 200 used Ford 9-inch rearends a month. Currie began in 1959 rebuilding rearends for electric industrial carts, and started specializing in 9-inch Fords in 1964.
By the mid-'70s, the company had a stockpile of over 50,000 used rearends spread over two storage lots. Today, it has only about 2,500 backup units left on hand. It buys them in Mexico, Canada and from all over the Midwest US. Passenger car rearends are preferred over those out of pickups because the car rearend in most cases still look new. Even though truck rearends' center section and the gear case are usually usable, because they run more miles and haul heavy loads, the axles, brakes, and gears are trash. Three years ago, Currie was paying $20 for a core housing. Now, it has to pay $60 and it's going to keep buying them until there are not anymore left. Currently the company can only obtain about a quarter of its needs. Supplies are about dried up and there are simply not enough Ford rearends left to meet demand.
About two years ago, Currie could see the writing on the wall and decided to start manufacturing its own rearends. "At the time, all the aftermarket parts that were available were for high-end drag racing," explains Ray Currie, one of four sons who now works in the business. "There were no new stock replacement parts for street use; everything was used. So we decided to make two new rearends. The first was the early-style, smooth-cover "hot rod" housing that was used from '57 up to '64. It is the most difficult to acquire right now. In addition, we also make the Torino/Ranchero (notched) heavy-duty housing. We beefed up both housings by making it out of thicker material. The Ford units were 0.180 inches and ours is 0.200 inches. The cover is also about 0.020 inches thicker than stock. The profile and basic shape is almost identical to the original. We also use a little bit better steel than stock Ford units do.
"The original Torino/Ranchero housings used a 3 1/4-inch tube that was swedged to fit the housing. We wanted to use a three-inch tube because that is what all the mounting brackets are designed to fit. We remade the housing to except the three-inch tube without any swedge. Some people like the round cover; some like the new style coverso both are available on this housing."
When Currie Enterprises decided to make the gear case, it did not want to re-invent the wheel. Ford's basic design was good, but Currie wanted to make it better with a few small changes. The most obvious one is the use of stronger nodular iron instead of gray iron used by Ford. Gray iron has a tensile strength of 30,000 psi, while nodular iron is 65,000 psi. Currie also used nodular iron in the double-ribbed carrier cap. Ford used gray iron in all its single ribbed caps, even on the factory nodular iron cases.
"Most of the failures that happened on stock gear case were in the carrier cap or the pocket bearing," notes Currie. "So those are the two areas where we added extra material. We also extended the rib on the outside that supports the carrier caps. This gear case is designed to be a stock replacement. It is not directed to high-end drag racing. It is targeted to people with 500 horsepower and less."
Currie Enterprises also manufactures a 9+ "Race Case" for street cars that are in the 500 to 900 horsepower range. It too is made of nodular iron, but completely reengineered to handle the higher power demands. It also uses billet spanner nuts and chrome-alloy carrier caps.
Currie pointed out, though, that many of the late-model racers (a 3200-pound car with 500 horsepower) running at Irwindale Speedway are using the companys street case because it is made of nodular iron and lighter than some racing cases.
As part of the 9+ manufacturing program, Currie also makes two pinion supports. The stock support and the big-bearing, Daytona-style pinion support. The company also manufactures both open and posi-traction carrier assemblies and two different yokes available, the 1310 and 1330 series and soon a 1350 series. In addition, there are two different styles of housing ends.
For its refurbished 9-inchers, Currie does not waste any parts of the used unit. For low horsepower applications, the company will re-machine every dimension on the axle, weld up and re-drill the boltholes, change the register diameter, change the flange diameter, regrind the bearing journal, and cut and re-spline the axle. Currie is basically using the axle as a forging and re-machining every aspect of it.
For higher horsepower applications, Currie makes all-new axles on CNC machines. The company is said to be the largest aftermarket axle manufacturer in the world, making over 30 specific axles for different applications. Currie offers a remarkably wide range of gear ratios as well. Just try and find that sort of selection in your local junkyard.

subset: commoncrawl


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Six floors, three buildings and top-notch classrooms and facilities – The McCombs School of Business has been the home of over 6,000 students. Personally, it is the only place on-campus where I spend my time: for classes, group projects, organizational meetings, studying, eating or just socializing with friends.
I would like to open the doors of the business school and give you a "mini tour" of the buildings' most prominent highlights. Welcome to my crib!
1) "The Family Group"
Situated by the 21st Street entrance of the business school, "The Family Group" is a sculpture designed by Charles Umlauf. Umlauf had a vision that focused on family; "the foundation upon which the world of business is built." The plaza where the sculpture is located also has several tables and chairs where students can study or wait before their classes start.
2) AIM Investment Center
One of the most prominent facilities in the business school is the AIM Investment Center. With the LED ticker constantly running overhead, the facility provides business students the latest updates on current stock prices. The AIM Investment Center is also a part of the EDS Financial Trading and Technology Center, which is dedicated to helping MBA students and undergraduate finance majors obtain real-world experience in managing investment portfolios and developing client relationships.
Continue reading MPA Cribs: A "Mini Tour" of the McCombs School of Business


text:
bonnie wrote:I am not sure to understand..
Is it the stroke smoothing (video example here) - Hold Z shortcut: set the drawing smoothness
If not, could you be more precise please?
u2bleank wrote:Hi Taro,
Can you please give me your config ? ( CPU, GPU, RAM, Os ).
If you have mulitple GPU try to force black ink to run using the imtegrated graphics and while slow, it doesnt experience the flickering effect.
If no try to enable the VSync ( Main Menu > Window> Preferences > GPU )


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No Drill Vulkaan Spare Toilet Roll Holder VK234
- Description
No Drill Vulkaan Spare Toilet Roll Holder VK234
No Drills, No Damage, No Worries, Never Drill Again is an innovative method of fixing bathroom accessories walls and floors. This chrome plated brass toilet roll holder is another of their fine products that's ready to use in twelve hours.
Chrome Plated Toilet Roll Holder
Never Drill Again technology is a unique and patented method of fixing bathroom accessories to walls and floors. Often the simplest ideas are the best ones and the Vulkaan toilet roll holder is a quality product with a simple fixing method. Chrome plated brass with a glistening cover the toilet roll holder stays firmly in place while in use, easy to replace toilet paper with a smooth swivel cover and holder the strong adhesive will guarantee you that it will still be attached to your wall.
Single Component Adhesive
Combining a high-performance single-component adhesive and a patented adapter, it lets you mount both heavy and light objects securely. Without noise, without dirt, and without causing damage to wiring or vulnerable surfaces, the bond is strong and permanent, and removal is possible without leaving a trace.


text:
Crimp terminal adapters allow different types of terminals to connect to one another. The term is also used as a catch-all for crimp terminals by some manufacturers.
What are crimp terminal adapters used for?
Crimp terminal adapters are used to connect different types of terminals, and are used for a variety of applications ranging from common household items to heavy-duty industrial equipment. In most cases, a special type of receptacle is required to receive a specific type of connector. However, if one or both connectors cannot be changed, an adapter can be employed.
Types of crimp terminal adapters
Crimp terminal adapters vary in type, as each model is designed to connect specific kinds of terminals, such as butt-splice terminals and quick-disconnect terminals. Types of crimp terminal adapters include male-to-female, male-to-male, and female-to-female.
The bodies of these adapters can be made of metal (such as brass, copper or stainless steel), or other materials like vinyl, while the plating is often made of nickel or tin.


text:
- Product details
- How to take
- Side effects
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- Testimonials
- Alternatives
Product Informationexpand all collapse all
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Location: California
Established: October 1, 1890
Size: 747,956 acres
In a high-country meadow two hikers crouch near the edge of a mirroring lake and watch a pika as it harvests blades of grass for a nest deep within a huge rock pile. When they resume walking, there is no other person in sight for as far as they can see. And on this sparkling summer's day, the view seems endless.
In the valley's crowded mall, families stroll by, eating ice cream, dodging bicycles. People pile in and out of buses. Shoppers hunt for souvenirs. Kids hang around a pizza place. Rock climbers, coils of rope slung over their shoulders, swap stories over beer on a patio. On a summer's day about 14,000 people are in Yosemite Village.
Both the solitude of the alpine ridge and the throngs of the valley are part of the experience when you visit Yosemite National Park. "No temple made with human hands can compare with Yosemite," wrote John Muir, whose crusading led to the creation of the park. To this temple come 4 million visitors annually. And about 90 percent of them go to the valley, a mile-wide, 7-mile-long canyon cut by a river, then widened and deepened by glacial action. Walled by massive domes and soaring pinnacles, it covers about one percent of the park. In summer, the concentration of autos brings traffic jams and air pollution.
Beyond the valley, some 800 miles of marked trails offer hikers easy jaunts or grueling tests of endurance in the High Sierra wilderness. Even the casual visitor can explore this solitude without getting outfitted for a backpack expedition.
This park, roughly the size of Rhode Island, is a United Nations World Heritage site. Here, in five of the seven continental life zones, live the mule deer and chipmunks of the valley and the marmots and pikas of the heights; the brush rabbit and chaparral of the near desert; the dogwood and warblers of mid-elevation forests; the red fir and Jeffrey pine of mile-high forests; the dwarf willow and matted flowers of Yosemite's majestic mountains.
Towering more than 350 stories above Yosemite Valley, El Capitan is the largest exposed granite monolith in the world.
The park's giant sequoia trees can live to be more than 3,000 years old.
Yosemite Falls usually stops flowing in late August. The cascade is fed solely by snowmelt, so the peak flow is in late May, when high snows in the Sierra Nevada melt. Over the warm summer months the flow dries up—but returns around October, when snow again begins to fall.
Lead Image: Upon entering Yosemite Valley, most people stop along the road to admire 620-foot-high (190-metre-high) Bridalveil Fall. A steep trail leads to its base, where swirling winds often assure that visitors get wet from the spray. PHOTOGRAPH BY RAUL TOUZON, NATIONAL GEOGRAPHIC CREATIVE.


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wingertfs necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 117 diseños de 16 diseñadores freelance.
Wingert Financial Services
Financial services is usually recognized as lending or investment firms. We are 80% "group benefits". Our business has transitioned to group benefits over the years, but also does investments and individual insurance products as well. Re-naming is out, we are know in the area and "Wingert" usually lands us on the first page of the search engines. Ideally we would like to add what we do to our logo, or create a tag line that works with the logo. Our problem is when we are networking, we have to constantly explain what we do. Our current message says financial services, which leaves alot of uncertainty as to what we do. The easiest fix is to add "Group Benefits, Investments, Insurance" somehow to our logo?
The goal is for someone to see the name and know what we do.
We would like a modern look, while maintaing a classic financial services feel.
You can view our current website at http://www.wingertfinancialservices.com
We are up for a total make over.......starting with our logo.
Our next phase will be to design cards, stationary, web-page, company brochures, presentation folders, etc. We would be inclined to directly use the winner for those projects.
Our target client for group benefits is a local(Seattle area) employer with 25-50 employees, who cares about their staff, are dissatified with their current plan, and recognize they need a quality broker.
We consider our selves to be high end, service oriented brokerage firm.
In addition to group benefits, we target individuals who need medical, life, disability insurance, etc.
We do not sell home and auto insurance......we protect people, not things.
Finally, we do financial planning, investments, 401(k)s...etc...
Attached is our current logo............We are happy to move on to a new look.
We would need the images send to high res/raw - printable format & jpeg for use in self made materials.
Thank you!!!!!!!
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


text:
'Best practices' nutrition measurement for researchers
'Best practices' nutrition measurement for researchers
Scientists have developed what amounts to a best practices guide to the most accurate way of measuring fruit fly food consumption. "While our study isn't the final technical reference on measuring fly food consumption, it will help guide researchers to think more carefully about nutrition and nutrient intake in their own studies," said the study's leader.
via Agriculture and Food News — ScienceDaily:
At first glance, measuring what the common fruit fly eats might seem like a trivial matter, but it is absolutely critical when it comes to conducting studies of aging, health, metabolism and disease. How researchers measure consumption can make all the difference in the accuracy of a study's conclusions.Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed what amounts to a best practices guide to the most accurate way of measuring fruit fly food consumption that could lead to more informed research and better decisions about directions in further studies."While our study isn't the final technical reference on measuring fly food consumption, it will help guide researchers to think more carefully about nutrition and nutrient intake in their own studies," said TSRI Assistant Professor William Ja, who led the study, which was published online ahead of print on March 30, 2014 by the journal Nature Methods.Researchers, Ja said, generally haven't given sufficient thought to feeding and nutrient intake when it comes to measuring fruit fly behavior, metabolism and health."If you're making a huge effort to change an animal's diet and trying to draw conclusions about what nutrition and nutrients do to animal health and lifespan," he said, "then one of the most fundamental parameters is accurately measuring food intake."TSRI Research Associate Sonali Deshpande, a first author of the study with graduate student Ariadna Amador and former TSRI Research Associate Gil Carvalho, underlined the importance of using the best measurement methods. "Drug studies, in particular, where compounds are added to fly food, are difficult to interpret without proper measurement of food and drug intake," she said.In the study, the team determined that radioisotope labeling food is the most sensitive and consistently accurate feeding method now available — levels of accumulated isotope are later measured in the animals. This method's main limitation appears to be underestimation of consumption due to excretion.For the most accurate measurement, the study suggested pairing radioisotope labeling with a more low-tech approach, such as the capillary feeder (CAFE). The CAFE assay, introduced by Ja in 2007, is similar to a water dispenser used for pet hamsters, but on a smaller scale."In a significant number of studies, we found that researchers appeared indifferent to the impact feeding might have on the experiment," Ja said. "This doesn't seem like good science to me. Can you imagine doing a mouse experiment, saying that you watched mice for four hours and saw no difference in feeding, then make conclusions about total caloric intake over days or longer?"Story Source:The above story is based on materials provided by Scripps Research Institute. Note: Materials may be edited for content and length.
For more info: 'Best practices' nutrition measurement for researchers
Agriculture and Food News — ScienceDaily


text:
Samsung Galaxy S IV Reported to Miss Out MWC
Samsung Galaxy S IV Reported to Miss Out MWC
The Samsung Galaxy S IV is undoubtedly one of the more highly anticipated smartphone devices in 2013 and rumors about the it have been off the rocket. It supposedly made its appearance at CES 2013 behind closed doors only; however, don't expect to see it at MWC, the most important show in mobile every year, next month in Barcelona.
Other than confirming that the Galaxy Note 8 will be unveiled at MWC, Samsung's mobile division head JK Shin has also officially confirmed that the S IV device will not be announced during the same event. This isn't too surprising of course, given that the S III was unveiled at a separate event in May last year. Samsung Lebanon, in a Facebook reply to a post asking about the Galaxy S IV's availability, they have mentioned that the device "won't be released before May 2013", which puts it at a later time frame than MWC.
Source: INewsS24 via Android Authority


text:
Last June I was fortunate enough to be commissioned by 'Sports Illustrated' to shoot a feature on World Champion Ski Racer Lindsey Vonn during her training programme in Salzburg, Austria for a feature in their Winter Olympic Edition
The most successful American Woman Skier in history
The brief was to shoot her while she was training and some portraits too
This was a really great gig for me and needless to say I wanted it to go WELL
In a situation like this the most important factor has nothing to do with equipment but it is the human factor, just how co operative is the subject going to be in the middle of an arduous, focused training programme?
Well, the moment I met Lindsey and her trainers I knew all was going to be just fine.
Lindsey is a really kind, warm, friendly and open person and she made the job in hand easy by being super co operative even though she was training a zillion hours a day
The first part of the shoot was following her and her trainers (from the comfort of a chase car!) on a long and tough (for you and I!) cycle ride through the Alps. It went on for hours....
I was getting some good shots during this but in the back of my mind I was focused on the location for a top class portrait
This process started the week before though as I had asked the crew at Red Bull to suggest some suitable locations and to send some shots of the locations to me, which they did
On a shoot like this you need all the help you can get and local knowledge is invaluable
And they suggested the peak of a nearby mountain
I say nearby but it involved a bit of a mission
I had to check it out, set my lights up and then wait with fingers crossed as it involved a dash by Lindsey to make the very last cable car of the day to the top of the mountain....which was also the very last cable car DOWN the mountain leaving just 30 mins to get the shot!
So I pre lit the shot using passing tourists
Ask nicely and tell them that they are being a stand in for a World Champion skier and you would be surprised how many agree! After all we all want to be part of something don't we?
I lit both the leaping shot and the alpine portrait pic with my Elinchrom Ranger Quadra
On an assignment like this when I'm working alone with no assistant and having to carry all of the gear myself it is a superb little light, packing a very respectable punch
When travelling light I use one of my favourite light stands
The Manfrotto 001b (It seems to have been superseded or renamed the 5001 or but it looks to be much the same)
It is one of the most affordable light stands made by Manfrotto and it is so versatile.
It folds down to 19 inches long which means it fits diagonally inside my carry on baggage
And though I'm unsure of its official load bearing spec I have put some quite silly loads on it which I'm sure would make Manfrotto wince. The stand seems to be 'keener' to flex than fall over. Unscientific on my part but it works for me. I have this light stand with me on my huge productions too, it has the knack of being the tool for the job on more occasions than I can recall
I used a Chimera Medium soft box (which you can see on my pre lighting shots)
Regular readers of the blog will know just how important this softbox is to the look and feel of my work
I shot the whole job on my Canon 5d Mk2 which I Love, Love, Love.
It delivers so much in such a small package, saving my poor old back
The Portraits on my 24/105mm Canon 'L' Series and the leaping shot on my Canon 'L' series 70/200 F4
Th light weight zooms perfect for my travels
Lindsey fought off a nasty injury she sustained prior to the Winter Olympics to win a Gold medal in the Women's downhill, becoming the first American woman to do so, she also won a bronze in the Women's Super G.
Richly deserved


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FUUFU - Japanese Yunomi Tea Cup Set in Irabo Glaze
|Not available.
Dai's Irabo glaze ceramics capture the Japanese admiration for the imperfect and the withered. Entirely handmade in Takayama, Japan, these pieces age beautifully with use, as their texture smoothens and colors deepen. Look closely and one can appreciate the artisanal details such as small divets where Dai's fingers carefully suspended the piece in mid-air as he painted it.
Dai believes that the beauty of Japanese pottery comes from its "harmony with nature". In keeping with this philosophy, Dai does not compromise when it comes to selecting his ingredients, whether it be clay from a particular hill 20km away or ash that is produced naturally and locally. He also shuns all tools of mass production, even opting for the mechanically-operated wheel over its electronic counterpart.
A pair of his and hers Japanese yunomi tea cups, handmade in Takayama, Japan. Ask any Japanese native, and it is agreed: Japanese tea must be enjoyed in a proper cup. No plastic, glass, or styrofoam cups allowed! This tea cup set comes in a wooden storage box, making it a fantastic wedding or housewarming gift!
Please note that these are one of a kind items, so the cups you receive will not be exactly the same as the ones shown.


text:
Mercer County, NJHome Menu
Quick Links
- Mercer County Board of Social Services
- Mercer County Community College
- Mercer County Improvement Authority
- Mercer County Park Commission
- Mercer County Library System
- Mercer County Prosecutor's Office
- Mercer County Technical Schools
- Mercer Property Information Portal
- New Jersey Courts
- Rutgers Cooperative Extension of Mercer County
- State of New Jersey
- Cure Insurance Arena
- Trenton Thunder
- Wildlife Center Friends
- Airport Development
Duties of a Freeholder
The Freeholder Board acts as a formulator of policy and provides a check on the powers of the County Executive. The Board also approves all county contracts and gives advice and consent to the County Executive's appointments of department heads, and appointments to boards and commissions. After receiving the proposed county budget from the County Executive each year, it is the duty of the Freeholder Board to thoroughly review, make appropriate changes, and then vote on the budget.
The Board of Freeholders' powers include:
- adopting the County's Administrative Code
- passing ordinances and resolutions
- reviewing, modifying, and adopting all operating and capital budgets
- evaluating and studying the County's Annual Budget before final approval
- making contracts with municipalities in the county
The Board of Freeholders oversee the provision of funds for all county departments to include:
- Mercer County Community College
- Vocational-Technical School
- Mercer County Board of Social Services
- Mercer County's correctional facilities, County Sheriff and the County Court House
- Mercer County Improvement Authority
- Mercer County Park Commission
- Mercer County Library Systems


text:
Comedian Vice Ganda is confident that his conscience is clear regarding the alleged vote-buying in the recently concluded PMPC Star Awards for Movies. The issue was broken by Jobert Sucaldito, saying that Vice's Best Actor win was paid (read story here).
Speaking on It's Showtime Wednesday, Vice Ganda said that he's aware of the controversy hounding PMPC but just ignored it since he knew for himself that he didn't pay for the award (WATCH VIDEO HERE).
"Nung nabasa ko natawa lang ako, tapos tumahimik ako. Sabi ko 'Kung kakausapin ko ang konsensya ko, ano kayang sasabihin ng konsensya ko sa akin?' Sabi ng konsensya ko sa akin, 'Kung nandaya ka, ibalik mo ang award. Kung hindi ka nandaya, yakapin mo ang award,'" Vice Ganda said before hugging his trophy.
On Tuesday, Philippine Movie Press Club, Inc. (PMPC), organizers of the Star Awards for Movies, already denied the said allegations (read PMPC's official statement here).
Vice Ganda has just returned from his highly successful "I-Vice Ganda Mo Ako sa Amerika" tour. The tour's first show was held at the John Logan High School Pavilion last February 28 where Vice entertained the audience with special guests, heartthrob Ejay Falcon and comedy duo MC and Lassy.
The tour's second show at the Los Angeles Theatre on March 1 also drew a huge turnout that Vice extended the show to three hours. The tour was presented by Happy Box, in cooperation with Redcheese Production, iOhmie Entertainment, and BG Productions.
For more Kapamilya updates follow/like BIDA KAPAMILYA on Twitter and Facebook.


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Rack of Lamb with Dijon Glaze over Wilted Baby Spinach Recipe
Lamb chops marinated with Dijon mustard, garlic, balsamic vinegar and herbs served over a bed of wilted baby spinach in garlic and oil. This is so good you'll be licking the bones clean!
I LOVE lambs chops, it's usually what I order when we go out for special occasions. But making them at home is really quite simple and a whole lot cheaper then going out to eat so any night can be a special occasion.
Buy them trimmed and frenched then all you have to do is season and cook. My husband claimed he didn't like lamb when I met him, but I quickly converted him. This is perfect for date night with your significant other!
Tip on using fresh herbs: Nothing beats the flavor of fresh herbs. Whatever you don't use right away, tightly wrap in plastic wrap and freeze in portions. When you need fresh herbs, remove from the freezer, it thaws in seconds and is ready to use in any recipe.
Gina's Weight Watcher Recipes
Servings: 2 • Serving Size: 3 ribs* • Old Points: 6 pts • Points+: 6 pts
Calories: 254.2 • Fat: 11.1 g • Carbs: 9.4 g • Fiber: 1.3 g • Protein: 25.4 g
1 lb New Zealand spring rack of lamb, fat trimmed and frenched
salt and pepper
3 cloves garlic, crushed
2 tbsp dijon mustard
2 tbsp balsamic vinegar
1 tsp agave nectar (or sugar)
1 tbsp fresh rosemary
2 tbsp fresh chopped parsley
Wilted Baby Spinach
Servings: 2 • Serving Size: half • Old Points: 2 pts • Points+: 2 pts
Calories: 69.2 • Fat: 4.0 g • Carbs: 6.6 g • Fiber: 3.2 g • Protein: 4.3 g
3 cloves smashed garlic
1 tsp olive oil
10 oz baby spinach, washed
salt and fresh pepper
Combine all ingredients for marinade. Season lamb with salt and pepper. Lay lamb chops in a bowl, add marinade and let it marinate 20 minutes or refrigerate a few hours or overnight.
Remove lamb from refrigerator if marinated overnight before cooking so that the meat comes back to room temperature.
Preheat oven to 450°. Roast lamb in the center of the oven for about 12 – 18 minutes for medium rare, or until the internal temperature is 130° – 135°. Remove from oven and cover with foil for about 5 – 10 minutes before slicing. Use a very sharp knife to carve between the ribs.
While the lamb is in the oven, heat a large sauté pan on hight heat. When hot add oil and garlic. Cook until golden then add spinach; reduce heat to low and and cover. Spinach will wilt in a few minutes, stir so all spinach wilts then season with salt and pepper. Remove from heat.
*Note: I'm aware there are 8 ribs on this rack, sometimes they have 6 or 7. A suggested serving size is 3 ribs, nutritional info is based on 6 ribs or 3 each. Adjust calories/points if you eat more than 3.


text:
Thursday, April 21, 2011
A Conversation on Human Dignity at the Kluge Center
The John W. Kluge Center at the Library of Congress announces a discussion, Dignity of the Human Person, from 8:30 a.m. to 12:30 p.m. on Tuesday, April 26, in Room 119 on the first floor of the Thomas Jefferson Building, 10 First St. S.E., Washington, D.C. The event is free and open to the public; no tickets are needed. Speakers include John Witte, Jr., the Jonas Robitscher Professor of Law, the Alonzo L. McDonald Family Distinguished Professor and director of the Center for the Study of Law and Religion at Emory University. Jean Bethke Elshtain will moderate.
2 comments:
- Manijhé said...
Being in London I am unfortunately unable to attend this event. I hope a podcast or video-blog will be published about it?
- April 21, 2011 at 2:39:00 AM EDT
- Dan Ernst said...
I'm unsure of the Kluge Center's practice here. Why don't you check with the Center via:
- April 21, 2011 at 8:35:00 AM EDT
Subscribe to: Post Comments (Atom)


text:
Erick Thomson Named Skyline Rookie of the Week
- Freshman picks up his 5th Skyline ROW award this season -
Lawrenceville, N.J. - Freshman attack Erick
Thomson (Floral Park, N.Y./Floral Park) was named the Skyline
Conference Rookie of the Week for men's lacrosse on Monday, April
Thomson earned Skyline Conference Rookie of the Week honors for the fifth time this season after a 14-point week. Thomson had seven goals and seven assists along with five ground balls as the Rams went 2-0. He had three goals and four assists in a win over Centenary. Thomson then had four goals as Farmingdale locked up the fourth seed with a win at Mount Saint Vincent.
The Skyline Conference Weekly Reports for spring sports are announced by the Conference on Monday nights. Reports (including players of the week and statistics) are available to view on the Skyline website at www.skylineconference.org.


text:
Infinite Wellness necesitaba un nuevo diseño de otro y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 26 diseños de 11 diseñadores freelance.
COFFEE PICKS™ are a zero calorie energy or 'pick-me-up' delivered in the form of a
tooth-pick! An easy to carry format and a compliment for regular coffee, latte and espresso drinkers, COFFEE PICKS™ are infused with Caffeine, delivering energy
COFFEE PICKS™ come in 2 delicious flavors:
1. Vanilla
2. Mocha
Our audience will be mainly ADULTS (30-50) who are looking for additional energy, alertness and enjoy the flavor of coffee.
Coffee lasts 30 minutes. COFFEE PICKS last for days with 20 in every package. They don't need cream or sugar making them a great choice for adults looking for their coffee hit after meals, in between coffees or just on-the-run.
COFFEE PICKS™ will have a national distribution chain and will be available at local convenience stores, retailers and gas bars.
Rich, smooth, sophisticated mixed with energy.
If you worked on our last ENERGY PICKS you'll have some idea of what was approved. This one might be a mx of that energy but softer... however, we are open to new ideas too! We invite them...
COFFEE PICKS™ requires:
1. Logo or word mark by flavor
2. Label design by flavor
3. Box design by flavor
The final design will work across any flavor, yet visually depict the flavor for easy selection. Through one or all of the following elements: color, type, imagery and graphics.
The label and box must contain:
- The product name
- Product ingredients
- Room for bar code
- Branded messaging on box top.
The package is a cylinder/tube is: 3" long. (From cap top to bottom) It's diameter is: 2"5/8. The Cap height is 7/16. The label should be rectangular in shape so special die cutting is not required. 4 color process is acceptable.
The tubes will be 2 layers down and 12 back. That makes 24 tubes per box. It keeps it flat and small. (Easier for retailers to justify the space)
The dimensions would roughly be: 3 2/16" wide x 9" deep and 2" high (when closed). When open it would stand about 7" tall with the branded panel standing up.
High resolution Vector and/or PSD files are required as art work my will need to be adjusted for final box and label production prior to printing. PLEASE SUPPLY CMYK FILES.


text:
With the cultural expectations of the Thanksgiving weekend behind us, there's a certain freedom in making our own traditions for the morning meal. The aroma of a steamy pot of coffee wafting through the house sets the tone for a leisurely late morning breakfast.
Breakfast is one of the simplest meals to make and planning ahead makes for ease of preparation. Pipérade is a colorful Provençal omelet of sautéed onions with sweet peppers and garlic that can be started the day before. In the morning just scramble your eggs with the prepared vegetables and season to taste. Crispy homefries make a suitable accompaniment. Diced Yukon Gold potatoes can be cooked ahead until barely tender,, drained until dry and left to cool completely or even refrigerated overnight then sautéed in butter and oil until crisp and golden. If pancakes are your thing, mixing the liquids and dry ingredients for cornmeal pancakes is a practical last minute preparation. Serve with cranberry maple compote that can be made the day before and warmed to spoon over the pancakes.
Bake or buy a sour cream coffee cake to top off the morning with that steamy pot of coffee!
Piperade Omelet
Julia Child introduced us to a pipérade, a vegetable sauté of Basque origin. She suggested finishing as an omelet. Here is my adaptation using farm fresh eggs.
Serves 4
1 tablespoon extra virgin olive oil
I medium onion, sliced
1 red and 1 yellow pepper, thinly sliced
1 large clove garlic, minced
Kosher salt and freshly ground pepper
½ teaspoon each chopped Italian parsley and fresh thyme leaves
6 to 8 large eggs
1. In a skillet, heat the oil and sauté the onion slices slowly, about 5 minutes. Add the peppers and garlic, tossing to coat with the onion then season to taste with salt and pepper. Stir the mixture for 2 to 3 minutes longer; add the herbs and stir to mix. Remove from heat.
2. Meanwhile, scramble eggs in a bowl until whites and yolks are combined. Season with salt and pepper and pour over the vegetables in the skillet. Return skillet to medium low heat; stir the mixture and cook, stirring slowly, until eggs are barely set and still moist. Taste for seasoning and serve at once on warm plates.
Mix dry ingredients ahead of time to make quick work of these nutty flavored pancakes. The use of skim milk, buttermilk and egg whites in the batter make these corncakes heart-healthy.
Makes 12 4-inch pancakes
1 cup all-purpose flour
3/4 cup yellow cornmeal
2 tablespoons sugar
1 teaspoon baking powder
1/2 teaspoon baking soda
1/2 teaspoon salt
3/4 cup skim milk
3/4 cup buttermilk
3 tablespoons canola or corn oil
2 egg whites
2 whole eggs
1. In a large bowl sift dry ingredients to thoroughly combine. Set aside.
2. In a clean bowl mix together milk and oil until blended. Beat egg whites and whole eggs until foamy and add to the milk and oil. Whisk to combine the mixture. Stir wet ingredients into the dry cornmeal mixture. Don't over mix; if a few lumps remain they'll work themselves out when cooking.
3. Heat a griddle or skillet over medium heat until hot enough to make a few drops of water bounce. Lightly oil griddle or skillet using a brush or paper towel.
4. Spoon enough batter onto griddle or skillet to make 4-inch rounds. Cook until bubbles on the surface break and edges are set, about 2 minutes. Using a thin, wide spatula, flip pancakes and cook until bottoms are golden brown, about 1 more minute. Continue until all the batter is used. Keep pancakes warm in a 180° oven. Serve with cranberry maple compote.
1 cup fresh cranberries
1/4-1/3 cup pure maple syrup, depending on desired sweetness
1. Combine cranberries and syrup in a small saucepan. Heat slowly over medium-low heat until mixture comes to a simmer. Cook until cranberries soften, burst and syrup turns red, about 10 minutes. Spoon warm compote over corncakes and serve.


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Gorgeous drivel: 'Immortals' delivers beauty, not story
Immortals is without doubt the best-looking awful movie you will ever see. Eiko Ishioka's costume designs alone deserve an Oscar nomination. "They weren't at all historically accurate," grumbled a woman in the elevator after the sneak preview, as if lots of documentation exists about the wardrobes of the gods. She added: "I guess that's what we deserve for using free tickets we got at a Blackhawks game."
One image after another is gob-smacking, including the early one in which a prison cell of thick granite, buried inside a mountain, holds the imprisoned Titans. We see them from above, chained standing upright, their teeth clamped onto iron rods. They've been this way for "eons." Other images include Greek villages carved from the sides of precipitous cliffs, spectacular temples and thrones, and a startling shot of the Oracles dressed in towering red costumes against a slate background. You look at these visuals and drink them in.
Alas, the movie makes next to no sense. It involves, in a very broad sense, the attempt by King Hyperion (Mickey Rourke) to conquer Greece and the battle to stop him led by a plucky peasant named Theseus (Henry Cavill). Full review.


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by Grant Moser
CaroleAnne Hensley, "a young 53," found her calling in life while having dinner at the Valley Green Inn over 15 years ago. "I saw some feral kittens running around. I took them to get spayed and neutered and started doing rescue work. My life was in transition, and I was also getting ready to go to France for a month.
"I had some cats of my own and thought to myself, 'Who is going to watch my cats?' I couldn't put them in a kennel because they'd be too upset, so I started looking into pet-sitting services. After speaking with them, I thought, 'I'm much more qualified than they are.' I thought I'd put an ad in the Chestnut Hill Local [offering pet-sitting services] and see what happens. That was in 1997."
Hensley pounded the pavement for the first few years. "I was a divorced, single mother, and I knew I had to make X amount each week to pay my bills. I was a vet tech and had volunteered with the Schuylkill Wildlife Rehab Center before, so I had experience with animals."
Hensley never did take that trip to France, but her company, Furry Buddies, has grown over the years, and she now has 13 women working for her. The company does up to 500 pet visits every week. Until 2009 Hensley lived in Erdenheim, but she then moved to a farm in Sellersville and expanded her service area "from Germantown to Quakertown.
"Many people have started their own pet-sitting companies, but many don't succeed because it's 365 days a year; it's definitely on weekends and holidays; it's very demanding. Anyone can walk a dog, but there's so much more, like walking in on sick animals and knowing what to do or finding a tree fell on the house. You want responsible people who can handle any situation that arises."
Apart from walking dogs and checking on cats, Furry Buddies also feeds them, provides medical services like insulin shots or pills, waters plants, picks up mail and even provides transportation help for pets who need to see a vet.
"I love animals," said Hensley, "and they're fun to work with. It doesn't matter what you look like, what kind of day you're having, most of them are head-over-heels happy just to see you. The only negative for me with my business getting so big is that I end up being in the office a lot, and I miss that one-on-one with the animals…
"When we meet a client, I ask tons of questions because I want to know about the pet and the client because I want to put the right girl with them. It really is a relationship; we keep the same person with that client for as long as they use us.
"The pets get comfortable with us. That's good because you notice when an animal is behaving oddly. For example, one client had three cats, and they would always greet me when I came, especially this one long-haired black one. One day it came to greet me at the door and then ran away growling. I noticed this because I had built a relationship with the animals. It turned out he had gotten constipated, and we were able to help him. Had I sent someone else, they wouldn't have known that behavior was not normal."
A cookie-cutter approach does not work in the pet-sitting business. "We have clients who are at work every day, and we walk their dogs at lunchtime. With a lot of my clients in Chestnut Hill, we've been working with the dogs since they were puppies, and now they're 15 or 16 years old. They hired us every weekday for all those years.
"And when people go away for the weekend or a vacation, we sleep at their houses. We provide medical care since a lot of pets are diabetic or because elderly people with sick pets might not be able to manage giving them their medicine, or need help transporting their animals to the doctor."
And while most of the business is cats and dogs, Hensley has also taken care of some uncommon pets. "I worked with a volunteer at the Wildlife Center, and her expertise was bats. She once brought her 10 bats to my house, and I pet-sat them and hand-fed each one. There was a crack in one cage, and I found one bat hanging on my kitchen curtain one day. We've watched people's snakes and lizards and even chickens. We'll work with any kind of animal."
Hensley has her own pets as well. "I have nine cats — and I'm not a crazy cat woman! It's because I've done so much rescue work over the years. I used to take my daughter on rescue missions, and she'd get attached, and we'd end up keeping some of them…
"I would like people to spay and neuter their animals and to adopt. Do not buy an animal because there are so many euthanized every year. I'm fortunate because the clientele I have, like in Chestnut Hill, are intelligent and caring people about their pets. It's not about the money for me; it's about making sure the animals are happy."
To learn more about Furry Buddies, visit http://furry-buddies.com/


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TOR Systems is a market leading provider of real-time, cost-effective, state of the art Ticketing, Booking and CRM solutions to visitor attractions.
TOR's real-time integrated booking and ticketing system is known as "Maxim." Maxim's core strengths are flexibility, stability, reliability, speed and ease. Maxim uses industry standard software and is continuously in development to keep up to speed with changing technology.
Behind the Maxim Solution lies a UK based business with a wealth of expertise, built up over more than three decades. The team at TOR have knowledge in designing and developing products for attractions of all types, as well as experience in the commercial and operational aspects of managing visitor attractions.
Our system provides functionality to manage bookings for groups or events, walk-in admissions, timed activities, online ticketing, membership, trade sales, retail and catering and integration to finance, stock control, CRM and access control systems.
Apart from the many benefits which the system itself provides, our honest and open approach to working with our clients has influenced the many years of success in the sector. The ability to listen and take on board feedback, as well as our continued efforts to provide high-quality support remains our focus.
We stand by the references of our clients. You are welcome to approach any of our clients or attend any of our user forums.


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Dear Editor,
On behalf of the State Bar of Georgia, I am writing to congratulate Kevin Gough on his appointment by public defender for the Brunswick Judicial Circuit, which includes Appling, Camden, Glynn, Jeff Davis and Wayne counties.
Georgia's public defenders fulfill a critical responsibility in our state's criminal justice system. A graduate of the University of Georgia Law School, Mr. Gough brings 25 years of experience in the legal profession, including service as an assistant district attorney, to the position.
State Bar sends congratulations
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