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BUFFALO, N.Y. – More African Americans get colorectal cancer (CRC) and die from it than any other ethnic or racial group.
UB is collaborating on a study to determine what influences African Americans to get screened for CRC and to develop interventions based on those influences.
While screening for the disease, by colonoscopy in particular, is the most effective way to detect colorectal cancer early and thereby improve treatment outcomes, studies show that there are substantial disparities for screening when comparing African Americans to other groups.
Compared to white Americans, African Americans are 20 percent more likely to get CRC and 18 percent more likely to die from it.
The University at Buffalo, Roswell Park Cancer Institute and Icahn School of Medicine at Mount Sinai are collaborators on a $2,658,940 grant from the National Cancer Institute to study what influences African Americans to get screened for CRC and to develop interventions based on those influences.
"There is a critical need to understand why so many African Americans aren't getting screened for CRC," says Marc Kiviniemi, PhD, assistant professor in the UB Department of Community Health and Health Behaviors and one of several principal investigators on the grant.
Kiviniemi says that while most behavioral research has linked cognitive decision-making (perceived benefits and barriers) and affective decision-making (fear and worry) to predicting whether individuals will get CRC screening, little work has been done on examining these dynamics among African Americans.
"This creates significant gaps in knowledge about the role of feelings in predicting and potentially increasing CRC screening for minorities," he says.
Kiviniemi says most educational material about CRC involves fact-based strategies for informing the public about the importance of CRC screening, but this does not seem to be an effective strategy for encouraging screening for African Americans.
The goal of this study, he says, is to use our understanding of how and why African Americans are influenced to participate in CRC screening and to develop narrative-based educational strategies to encourage CRC screening in African American communities.
The study will examine the impact of two randomized community interventions on cognitive and affective factors and their resulting influence on health care seeking and CRC screening behaviors for African Americans.
Kiviniemi is an expert on how individuals' health decision making is influenced by feelings. He began his research in 2004.
"At first I was just observing and listening to people talk about their health behaviors and noticing that there were situations where people knew that they 'should' do something but didn't really want to – like exercising or getting a colonoscopy – or other situations where they knew that they shouldn't do something but liked doing it – like eating junk food," he says.
Most of the theories that existed to explain people's health behaviors, Kiviniemi says, could explain the "should do" or "shouldn't do" judgments people were making but couldn't account for the more visceral, emotional reactions that lead people to do things like eat junk food or to not get a screening test.
"For several years now, my lab's work has focused on understanding how individuals' emotions affect their choices about health," says Kiviniemi.
"From a practical, health promotion perspective, we address the question of how we can shift the emotional associations people have with health behaviors to encourage them to make healthier behavioral choices."
Kiviniemi's lab will figure prominently into the study. It is set up for the work on study design and data analysis.
His fellow principal investigators on the grant are Deborah Erwin, PhD, Roswell Park Cancer Institute, and Lina Jandorf, MA, of Icahn School of Medicine at Mount Sinai. Gary Winkel, PhD, also of Icahn School of Medicine at Mount Sinai, is a co-investigator.
Media Contact Information
Sara Saldi
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Tel: 716-645-4593


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Sunday Jazz with Jeff Duperon
Sunday, 9 pm to 12 midnight
- Hosted by Jeff Duperon
Wind down your weekend with Jeff Duperon as he brings you new, creative interpretations of your favorite jazz standards. You'll enjoy fresh arrangements and orchestrations, like a Big Band version of a Monk tune, or a young vocalist bringing life to the music of Lady Day or belting out a "not-so-standard standard." Jeff occasionally features concert broadcasts from local venues and festivals. Tune in to hear what happens when new life is breathed into the classics.
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subset: commoncrawl


text: Last week, we saw some big name titles go lite on us. This week, the fun keeps on rollin' as developers continue the trend of releasing free versions of their games and apps. While many of these lite apps won't offer you hours of gameplay, they'll certainly give you a taste of whether it's worth your hard earned dosh. Those looking at trying out new Tower Defenses can now test out geoDefense (one of the most challenging and fun TDs at the App Store) and Hudson's brand new ElementalMonter TD. Players can also test drive some of the most enjoyable time management games in Supermarket Mania and Hospital Havoc. Gameloft's Wild West Guns, one of the best "light gun" shooters on the iDevice also goes lite, along with Vector Tanks and Sway. Be sure to check out the entire list below for some quality lite apps.


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Grant helps Auckland scientist to dig deeper into complex disorder.
An Auckland University hunt for the genetic causes of autism has been secured by a five-year Government grant.
Scientist Dr Jessie Jacobsen is one of 10 top up-and-coming researchers to be awarded the Rutherford Discovery Fellowships, administered by the Royal Society of New Zealand and worth $8 million over five years.
It is estimated that 1 in every 100 people in New Zealand has autism spectrum disorder, a group of conditions including "classical" autism and Asperger syndrome. Autism spectrum disorders can have a range of symptoms which typically include impairments in communication and language, repetitive behaviours and restricted interests. The exact causes are not known.
Dr Jacobsen, who won the MacDiarmid Young Scientist of the Year award in 2007 for her PhD research on Huntington's disease, became interested in the causes of autism spectrum disorders during her post-doctoral research in Massachusetts.
She said a study in the United States earlier this year had estimated the incidence at one in 88.
"That's another reason why we need to get on and understand the disorder, the prevalence seems to be rising. It affects a huge portion of the population."
Her research involves analysing DNA from blood and saliva samples taken from people who have been diagnosed with autism spectrum disorder, looking for genetic mutations or variations and linking them to clinical descriptions of the patients written by their doctors.
"It's quite a complex disorder. The latest sequencing techniques have made it possible to look at the whole genome simultaneously, instead of just small sections at a time. That's allowed us to look at more complex disorders.
"Autism spectrum disorder has several genes that appear to be involved."
Similar gene studies to hers have been carried out overseas but it was important to do the work here too.
"I was keen to do it with the New Zealand population which has these unique population groups and well-characterised samples.
"We have these well-described patient samples, which makes relating the genetics that we find back to what the clinical presentation of the disease is much easier.
"It means when you find a mutation in a gene or a variant in a gene, if that gene is involved in something particular, you can look back at the clinical presentation and see if that particular patient had a more severe form ..."
There is no cure for autism, but various therapies can be used to help manage some of the symptoms.
Dr Jacobsen said she hoped her research would lead to better therapies and educational support systems.
Each fellowship provides $160,000 a year, which goes towards the researcher's salary and programme of work.
The Royal Society said the fellowships were aimed at developing and fostering the future leaders of New Zealand science and innovation.
Science and Innovation Minister Steven Joyce said high-quality research was the cornerstone of innovation and key to expanding the economy.
"The scheme aims to help accelerate the development of researchers who have been recognised for excellence within their respective disciplines."
The other nine
* Dr Geoff Willmott, Industrial Research. To develop new tools to manipulate fluids at the sub-micro "nano-fluid" level.
* Dr Lara Shepherd, Te Papa museum. Will investigate domestication and decline of several New Zealand plant species, dating from pre-European times.
* Dr Nicholas Rattenbury, Auckland University. Looking for Earth-like planets orbiting stars elsewhere in the universe.
* Dr Martin Allen, Canterbury University. Will study new semiconductor materials such as zinc oxide, trying to design new tools to assess risks and benefits of ultraviolet radiation to human health.
* Clemency Montelle, Canterbury University. Will analyse Sanskrit works and artefacts to understand ancient Indian maths and astronomy.
* Dr Shinichi Nakagawa, Otago University, Zoology. To study how and why genetic and physical diversity is maintained.
* Dr Peter Mace, Otago University, Medicine. Looking at molecular signalling mechanisms at the border between cellular life and death.
* Dr Timothy Woodfield, Otago University. Mixing engineering, biology and medicine to find new ways to regenerate bone and cartilage to fix damaged joints.
* Dr Barbara Anderson, Otago University. She aims to disentangle the roles of ecology and evolution in how species respond to climate change.


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In order to ensure the safety and security of the workplace, the University strictly prohibits violence or threatening behavior. Anyone who engages in any violence in the workplace or in threats of violence or threatening behavior is subject to disciplinary action, up to and including termination of employment and, in the case of an employee who also is a student at the University, additional student disciplinary action up to and including expulsion. The University may, as it deems appropriate, seek legal sanctions against violators.
Prohibited behavior includes but is not limited to hitting, shoving, sexual assault, attacks, stalking, verbal or non-verbal threats, electronically communicated threats or threatening behavior, vandalism, arson and possession, use or threatened use of a weapon of any type.
To fulfill this commitment to a safe work environment for all, the following is University policy:
The University specifically prohibits the possession of weapons by any employee or student while on, or in the vicinity of, University owned or controlled premises, regardless of whether the owner is licensed to carry such weapon. This ban includes keeping a weapon or transporting it to another location. Employees are also prohibited from carrying a weapon while performing services for the University on or off University premises. Faculty, students, staff and visitors who are licensed to carry a firearm are prohibited from carrying such firearm without the express written permission of the Office of Public Safety.
Weapons may include but are not limited to guns, knives, explosives, and like or similar items with the potential to inflict physical harm. Included are disarmed weapons and simulated weapons which could reasonably cause apprehension. Appropriate disciplinary action, up to and including termination and expulsion in the case of an employee who also is a student, will be taken against any employee who violates this policy.
All employees have the responsibility to report threatening or violent behavior, whether that behavior is exhibited by a member of the University faculty, administrators, staff, student body or a visitor. Employees should contact one of the following at once:
Whichever office receives the complaint first must insure that the other three offices are informed as soon as possible. The HR Officer will notify the Office of Employee Relations and, working with that office, decide what steps are needed to address the problem and what other resources (e.g. Office of Public Safety, Employee Assistance Program) are appropriate to manage the incident.
In an emergency where you believe someone to be in imminent danger, contact 911 at once and then notify the Office of Public Safety at ext. 8-2222.
In the event of a major workplace incident that affects or has the potential to affect the mental health of University employees, the University provides initial counseling and support services through the Employee Assistance Program, Carebridge Life Resources. This service is available to employees and their immediate family members and the toll-free number is 1-800-437-0911.
All employees have responsibility for reporting any violent or threatening behavior to a supervisor or HR Officer at once. The University also encourages employees to contact their Human Resources Officer and/or the Employee Assistance Program that help them to learn about working with each other, communication, problem solving, building effective working relationships, stress management and other related topics.
Supervisors in particular have the responsibility to learn to recognize the early signs of hostile, potentially threatening behavior and to take appropriate preventive action. Ignoring early signs can be mistaken as approval of the behavior and can lead to escalation.
Below are signs that may indicate potential for violence:
Supervisors are not expected to be expert in detecting the potential for violence and should contact the Office of Employee Relations, Human Resources Division at 81290.
The University provides an Employee Assistance Program to all full-time and part-time employees and their immediate families. Employees are encouraged to use Carebridge Life Resources whenever they feel the need for guidance in coping with life's difficulties. Supervisors are encouraged to turn to Carebridge Life Resources for help in interpreting troubling behavior in the workplace and for guidance in how to refer a troubled employee to Carebridge Life Resources for help.
Carebridge Life Resources can provide resources, referral to treatment and even short term treatment in certain situations. The service is completely confidential.
Effective Date Supersedes N/A Issuing Authority Office of Human Resources Responsible Officer Vice President


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Rovnix bootkit framework updated
Changes in the threatscape as regards exploitation of 64-bit systems, exemplified by the latest modifications to the Rovnix bootkit.
Changes in the threatscape as regards exploitation of 64-bit systems, exemplified by the latest modifications to the Rovnix bootkit.
The Java exploit for CVE-2012-1723 is already included in the latest update of the BlackHole exploit kit.
Carberp is a unique case, with all the guys who organized really big botnets and made big profits (millions of US dollars) being arrested.
Aleksandr Matrosov and Eugene Rodionov presented their research into "Smartcard vulnerabilities in modern banking malware†at PHDays'2012.
Group-IB and ESET Russia assisted in the investigation that led to the arrest of 6 people suspected of stealing 125m roubles from bank customers in Russia .
The latest research on the Win32 Carberp gang and the technicalities and evolution of the malware, as presented at CARO 2012.
Aleksandr Matrosov notes a new exploit kit approach to hiding redirects using implicit iFrame injection. (NB Nuclear Pack, not Blackhole.)
The Blackhole exploit kit has been updated to version 1.2.3 and includes a new exploit for the Java CVE-2012-0507 vulnerability, which ESET calls Java/ Exploit.CVE-2012-0507
Group-IB's joint investigations with the FSB and MVD resulted in the arrest of a gang of eight accused of larceny, creation of malware, and unauthorized access.
ESET is seeing a new step of evolution for the Rovnix bootkit family.
Facebook fraud, Carberp, statistics and a DDoS plugin.


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If I ever had a chance to interview a member, I'd ask him how the AB formed and he'd most likely tell me it formed in 1967 in San Quentin because the whites were outnumbered by the blacks and Latinos so all the white inmates got together to watch each other's backs and formed their own "gang".areefce wrote:HEY ZEEBO WHY DONT YOU GO UP TO AN AB AND TELL HIM THEY ARE A BUNCH OF SCARED WHITE KIDS.THIS THREAD IS STUPID.
And see, they would had to have been scared before creating the gang or otherwise the AB would have never been formed. If they were such tough guys, they'd made it on their own.


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I don't see my song in the list for Young Blood. However, after listening to the other contenders, I'm not to sure I want to have it added to the list. Since I haven't submitted a song in, like, a year, I'm just looking for what I did wrong. Thanks!
I guess I messed up
Let us know when something isn't working correctly, or if you find a typo. Do not post complaints or suggestions here.
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- Lunkhead
- Ozzy
- Posts: 6697
- Joined: Sat Sep 25, 2004 12:14 pm
- Instruments: many
- Recording Method: cubase/reason/mac/tascam4x4
- Submitting as: Berkeley Social Scene, Merisan, Tiny Robots
- Pronouns: he/him
- Location: Berkeley, CA
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Re: I guess I messed up
Your song seemed to have multiple layers of copyright issues.
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2 posts • Page 1 of 1


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New strategy directly activates cellular 'death protein'
Researchers at Dana-Farber/Children's Hospital Cancer Center have devised a strategy to directly activate a natural "death" protein, triggering the self-destruction of cells. They say the development could represent a new paradigm for designing cancer drugs.
In an article published as an advanced online publication by Nature Chemical Biology, scientists led by Loren Walensky, MD, PhD, report they identified a prototype compound that "flips a switch" to directly activate one of the most powerful death proteins, known as BAX, triggering apoptosis, or self-destruction of unwanted cells.
"Having identified the 'on switch' for the BAX protein several years ago, we now have a small molecule that can directly turn this death protein on," says Walensky, senior author of the report. The first author, Evripidis Gavathiotis, PhD, carried out the work in Walensky's laboratory; currently he is an assistant professor at Albert Einstein College of Medicine in New York.
The development exploited the discovery by Walensky's team of a distinctive groove, or "trigger site," on the BAX protein that converts it from a quiescent form to an active one. When activated, BAX damages the cell's mitochondria, releasing signals that break the cell apart and digest its pieces. This process of programmed cell death is part of a natural check-and-balance mechanism to control cellular life and death.
In search of molecular compounds that could fit snugly into the trigger site and jump-start BAX, the investigators used computer-based screening to sift through 750,000 small molecules from commercially available libraries.
The search paid off with the identification of a small-molecule compound named BAM7 (BAX Activator Molecule 7), which selectively bound to BAX and flipped its "on switch," turning it into an active death protein.
"A small molecule has never been identified before to directly activate BAX and induce cell death in precisely this way," explains Gavathiotis. "Because BAX is a critical control point for regulating cell death, being able to target it selectively opens the door to a new therapeutic strategy for cancer and perhaps other diseases of cellular excess."
But wouldn't switching on cell-death proteins in a patient kill normal cells as well? The researchers say that other compounds now in clinical trials that target the apoptosis pathway haven't shown such side effects. Gavathiotis suggests that there are sufficient extra survival proteins in normal cells to protect them against pro-death BAX. Cancer cells, however, are under stress and their survival mechanism is stretched to the limit, so that an attack by BAX pushes the cells over the brink into self-destruction.
The Walensky group has previously developed other compounds designed to spur apoptosis of cancer cells. These agents do so either by blocking "anti-death" proteins, deployed by cancer cells to prevent BAX and other death molecules from carrying out their assignment, or by blocking both "anti-death" proteins and activating "pro-death proteins" simultaneously. BAM7 is the first compound that avoids combat with cancer cell's survival proteins and binds directly and selectively to BAX to turn on cell death.
"We find that small molecule targeting of the BAX trigger site is achievable and could lead to a new generation of apoptotic modulators that directly activate BCL-2 executioner proteins in cancer and other diseases driven by pathologic apoptotic blockades," write the authors.
Walensky and his colleagues continue to work on BAM7, which is a prototype of drugs that might one day be approved for cancer treatment. Several biotechnology companies have already expressed interest in developing the compound, he says.
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Massage Therapy in Dallas, TX
While getting a massage is an excellent way to unwind after a particularly long week, it may also be beneficial to those struggling with certain physical issues. When you want a massage therapy practitioner in the DFW Metroplex or a nearby community, work with Sports & Spine Chiropractic.
Our knowledgeable, friendly staff is available during convenient hours, which may simplify the process of scheduling an appointment for some clients. Every member of our team is dedicated to making our patients a top priority, and we also:
- Speak both English and Spanish
- Have been serving our community since 1994
- Aim to foster a warm, relaxing atmosphere in our office
If you're ready to end your search for massage therapy in Dallas, TX, let the professionals at Sports & Spine Chiropractic provide you with the treatment that you're looking for. Give us a call today to receive answers to your questions or to make an appointment.
Limited Time Offer!
$39.00 Exam and X-rays
Sports & Spine Chiropractic
17740 Preston Road
Dallas, TX 75252972-210-2613
Not available for use with Medicare or other federal programs.
Offer Ends July 7, 2020
Your offer has been sent to your email.
Reading the reviews vs the actual experience was like night and day. I have been to several chiropractic offices but I've never had such a great experience until now. My 1st adjustment had me feeling better instantly. I understood that an X-ray was beneficial so that the drs would really know what they were working with, which made me feel comfortable and gave me peace of mind. It's strange to think that people are uncomfortable with that... The front desk girls are very on top of things and made me feel right at home. I was able to have my blood drawn to visit with the nurse practitioner next appt. (which is so convenient since I'll be there anyway) After my adjustment I was directed to a few other therapies that I've never done before. I was a little weary at first but Jordan explained how each one worked and how it would benefit my needs. I look forward to my next appointment(: Don't believe all of the bad reviews. Try it out for yourself!! You won't be disappointed :)
These doctors and therapist really care about your body! Had a deep tissue and multiple adjustments, they really sought my wellness and I was tremendously blessed!
Great service. Got me back on my feet quickly and professionally!
Went for a few months straight../ gave me a deal of $25/wk for 3 adjustments a week... completely fixed my back that was hurting my entire life...these guys are amazing
After years of lower back pain following a pregnancy and carrying around a small child, I finally took the recommendation from a friend to try a chiropractor. I was a little nervous about the whole process but Dr. Choate was great about explaining everything and making me feel comfortable and I walked out feeling 100% better after my first visit! After a few follow up visits I feel like a new person and am back to my lifting routine at the gym!! Would totally recommend to anyone on the fence about chiropractic care!
I absolutely loved my experience! Super friendly staff! especially the phlebotomist Q and Aisha their awesome!!!
Doctors were very knowledgeable and caring. They have an excellent facility with a wide range of equipment therapies. Very clean, massages were very helpful.
This place was awesome, the staff,my massage,and the decompression helped my back tremendously. I will recommend you check them out.
These guys have helped my sports injuries many times.
Mind you folks, I found this amazing crew via Groupon. I simply came in for a massage but was given the royal treatment. The atmosphere is welcoming and they truly take pride in your well being. I have been to a chiropractor before, their treatment plans expired way to fast and without true benitifit. I'm excited and grateful for the care Dr. Bonds and his staff provide. They not only gave me a personalized treatment plan but were willing to work with my income as a student. Check them out guys, seriously you won't regret it.
I really loved the massage, it was great.
I work in the building so convenient for me. Love that massage is included in my plan, especially when they're actually great massage therapists
Quality Service and very Professional
Everyone in the office at Sports Spine Chiropractic is friendly and caring. The minute you walk in you are welcomed by smiling caring people. The wait time is nothing even though they are very busy they all take time to say hello and make sure you are comfortable. Dr Bonds is very competent and caring He always has time to make sure you are feeling ok after the adjustment His office is on the cutting edge as far as technology and treatment is concerned and they offer a variety of things you can do to help you back to good health. I have personally been helped by them getting over car wrecks and other issues for over 6 years. I would not go anywhere else.
You guys got me back in the game...
I don't know how you did but you guys worked a miracle on me. The adjustments and therapy I received was spot on. Thanks Sports and Spine Chiro! You guys got me back in the game...
I was on vacation in Dallas, visiting my Mother, and my back was killing me. To the point I couldn't sleep. You guys got me right in, took x-rays, figured out a probable cause, and treated me twice in one week. I felt better within days. Very professional staff and facility. I have since tried to find a place in Denver, but could not find a place even close to your service. No one even wanted to see the x-rays you guys sent with me. Please come to Denver.
Incredible experience
Had a groupon for massage and decompression. Had suffered for years with lower back pain. They offered me x-rays after a consultation with a doctor. Explained everything very well and did treatment. I have never felt better after about 5 treatments. I have sciatica with some disc problems. Well worth it! They know what they are doing and are nice people.
High quality service
I loved the service I got, loved the staff and Dr. Harris in particular is a friendly lovely woman. I highly recommend them, they know what they're doing.
Left feeling awesome
Stephanie was my massage therapist and she really knew what she was doing. She listened to my needs and worked out my body in the places that I needed. She knew that when I said I had a tight lower back that she needed to apply pressure on my hips to relieve my lower back pain. And then, the chiropractor aligned my neck and back amazingly! I left feeling euphoric and like a had grown 2 inches!
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Our courteous chauffeurs have been serving customers in the Downriver, Monroe, and West Northwest Areas for more than 15 years.Learn More
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Bozzo's Limousine Service has been New Boston's most trusted choice for limousine rentals, party bus rentals and luxury transportation service for over 15 years. our luxurious limo fleet is well suited for all of your private and special occasion needs. We specialize in all aspects of luxury transportation and strive to deliver the highest quality of service to all of our customers.
Our courteous chauffeurs have been serving customers in the Downriver, Monroe, and West Northwest Areas for more than 15 years. Our company has been built on promise and good business practices. Providing our clients the service that we promised from the moment we answer their call to the final drop off. We want your experience to always be the BEST. We'll deliver a premium service a detailed sanitized professionally cleaned vehicle in complete working order and dazzle you with a prompt and professional service from beginning to the end.
Luxury Wedding Transportation Service in New Boston, MI
As one of the most important days of your life, there's no room for uncertainty on your wedding day. You need a wedding transportation service that you can rely on! At Bozzo's Limousine Service, we provide the impeccable, five-star limousine and shuttle transportation services you should expect on your wedding day. Our drivers will work with you to learn the details of your night, from picking up and dropping off guests, to ensuring you meet your destination on time with comfort and style.
We'll also handle the planning and scheduling, so you and your guests won't have to stress about sticking to the itinerary or making it to the destination on time. Our drivers are dedicated to providing first class service every step of the way, and it is their goal to meet your needs and exceed your expectations.
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In 1935 the U.S. Congress proclaimed the first Sunday in August as National Friendship Day. This year it falls on Sunday, Aug. 5 and it will be celebrated and observed in many countries and cultures. As adults we understand the value of friendship. Its not only important to us but is also very important to young children. Relationships and social interactions play an important part in a young childs life. The experiences from these early years lay the foundation and form a template for future relationships.
Children need friends. Companionship provides fun and laughter, as well as solace and warmth in times of personal difficulties. Friends can help us develop a sense of who we are and help us learn to get along with other people. Friendships clearly play a vital role in a childs emotional health and well-being and also help strengthen ones interpersonal skills.
Peek inside a preschool classroom and you will often find children altering their games so that their friends can play along. At circle time, they encourage and help their friends participate. In short, friendships are forming.
In very young children, as with older children, friendship is defined as a positive relationship between two children. Young children who are friends are interested in being near one another, have fun together, will choose to play with one another over others in a group, and challenge themselves and the friend to try new and more complicated tasks.
Some interactions between children of this age may appear to the casual observer to be meaningless or without structure, yet many involve back and forth turn-taking, and a clear awareness of how the actions fit together. These early games can help solidify a growing friendship. Often young children interact by copying one another. One child will perform an action, and then look at the other child, using body language to ask them to repeat the same action. This creates a similarity between the children. When children cannot yet speak, this seems to say, Look, I like to do the same things you do! Mimicking behavior shows cooperation and the desire to keep the interaction going. These games can have their own set of rules that the two children make up, and can be played once, or repeatedly, often across days. These are among the most complex interactions for toddlers, both requiring and encouraging the child and the friend to develop socially and cognitively.
Friendships among very young children provide more than just entertainment. In a 1994 study by Whaley and Rubenstein, very young children assisted their friends, willingly gave up a toy to a friend, and supported a friend in a conflict he/she had with a peer. These acts of sharing, helping and loyalty were done spontaneously, without prompting by an adult. Very young children also can develop a strong sense of empathy for their friends. A 1981 study by Musatti and Panni notes that the observed children (all younger than 18 months) were three times more likely to respond to a crying friend than a crying child they did not know. Many times the toddler would try to console the distressed friend by coming close to the friends face and smiling, talking or singing, or even offering a toy in an attempt to cheer the friend up. Sometimes, the toddler would ask for help by getting an adults attention and motioning towards the crying child.
Parents and educators can take measures to foster and deepen friendships among very young children. Below are 6 suggestions provided by researchers at the FPG Child Development Institute at UNC Chapel Hill:
Group play is important but sometimes allow two children some privacy so they can concentrate on their relationship and play together. This may mean allowing them to exclude other children at times. Parents can arrange play dates between their child and another friend.
Specific environments also can help support friendships as well as encourage new ones. Small, cozy spaces just big enough for two encourage closeness. Toys, materials and playground equipment that need two partners to function well promote working together and communication.
Adults can provide more than one version of similar toys and materials. This allows friends to perform the same action at the same time, an important part of very young childrens friendships.
Adults can allow noisy, silly, active play in the group or pair, so that the children can experience the closeness created by shared laughter.
For younger children with disabilities, parents and educators can act as matchmakers. Children who have shown an interest in one another, or in similar activities, can be encouraged to play together or at least be near one another, both in a group and separately.
Though adults are often in the background for childrens friendships, they can be more involved when the children are just learning to communicate. They can carefully join the children in play in order to keep the interaction going, or to explain a childs actions that the friend might not understand.
Friendship among very young children is not only possible, but beneficial. With support and encouragement from adults, young children can form connections that not only provide enjoyment, but help promote their growth and development in many areas.
Pamela Wilderson has worked with young children for more than 25 years as a Speech-Language Pathologist and currently is the Child Find Coordinator for the San Juan Board of Cooperative Educational Services (SJBOCES) and also the Coordinator of the Pyramid Model Partnership, a partnership between the Montelores Early Childhood Council (MECC) and SJBOCES. The Partnership works to promote the Social Emotional competence in young children and provides a framework for teachers and parents to use to prevent challenging behaviors in young children. For more information about the Partnership, Pamela can be reached at 565-8411.


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The lead singer of a popular band is facing assault charges after investigators say he threw microphone stands into the crowd during a concert at Six Flags Great Adventure in New Jersey.
Police say it happened Saturday night during Six Flags' "FestEVIL," a music festival featuring metal, punk and hardcore music. Post-hardcore band Falling in Reverse served as the headline act. During their set, police say the band's lead singer, Ronnie Radke, 28, threw three microphone stands into the crowd.The incident was captured on youtube. Watch it here.
Police say a 16-year-old girl and a 24-year-old man were struck in the head by the mic stands, according to the Asbury Park Press. Police told the APP the girl suffered bruising and a cut on her head while the man was treated at the scene for his injuries.
U.S. & World
Jackson Police arrested Radke and charged him with simple assault and aggravated assault, according to the APP. The APP reports he was released on $25,000 bail.
Kristin Siebeneicher, a Six Flags spokeswoman, said the following to the Asbury Park Press:
This was the first metal show that we've ever had and will be the last. We have no plans to host another metal show.
This performer was completely reckless. He had complete disregard for the safety of his fans. His actions were totally unacceptable. It's not the type of entertainment that we want to be producing.


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Makes about 24 cookies
2 cups (10⅔oz) plus 2 tablespoons all-purpose flour
½ tsp baking soda
½ tsp salt
12 tbsp/1½ sticks/170g unsalted butter, melted and cooled
1 cup packed (7 oz) light brown sugar
½ cup (3½ oz) granulated sugar
1 large egg
1 large egg yolk
2 tsp vanilla extract
1½ cup (9 oz) semisweet chocolate chips
Adjust the oven racks to the upper- and lower-middle positions and heat the oven to 165oC/145oC fan oven/ 325 degrees/ Gas Mark 3. Line 2 large baking sheets with parchment paper. Whisk the flour, baking soda, and salt together in a medium bowl.
In a large bowl, beat the melted butter and sugars together with an electric mixer on medium speed until smooth, 1 or 2 minutes. Beat in the egg, egg yolk, and vanilla until combined, about 30 seconds, scraping down the bowl and beater as needed.
Reduce the mixer speed to low and slowly add the flour mixture until combined, about 30 seconds. Mix in the chips until incorporated.
Working with 2 tablespoons of dough at a time, roll the dough into balls and lay them on the prepared baking sheets, spaced about 2 inches apart. Bake the cookies, one sheet at a time, until the edges are set and beginning to brown but the centers are still soft and puffy, 15 to 20 minutes.
Let the cookies cool on the baking sheet for 10 minutes, then serve warm or transfer to a wire rack and let cool completely.


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Power your knowledge with continuing education. Taught by scientists and PhDs.
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Learn about how freezing can affect the nutritional value of food, to the truth about organic meat!
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Fish is simultaneously touted as both a brain-boosting superfood and something full of deadly environmental toxins. So, what's the truth behind this fishy conundrum? We delve into the science to find out.
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Fresh vs Frozen Vegetable Analysis
Is fresh always better, or does freezing lock in goodness? We've been investigating the nutritional properties of fresh and frozen vegetables, and put them head to head for you in this comprehensive module.
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What exactly is different about the properties of organic meat? Organic meat is often thought of as being healthier and better for us, so in this module we examine whether the science, and the law, really live up to this good reputation.
In this module you will learn…
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text: The Deployment Sessions–001: Deploying a Windows Store App with Configuration Manager 2012 SP1 Written by Simon May on March 13, 2013 in deeplinking, deployment, deployment sessions, Enterprise Client, system center 2012 sp1, Video Series, Windows 8 This is the first in a new series of videos I'm working on that show how deployment works for modern apps, Windows Store apps, Windows 8 apps, Windows RT apps or Appx packages – whatever you like to call them. There are a few ways that you can deploy these types of apps to Windows 8 and Windows RT devices using System Center Configuration Manager 2012 SP1, Windows Intune and Microsoft Deployment Services Toolkit 2012 SP1 (MDT 2012 SP1). In this first video I'm take a look at deeplinking an app from the Windows Store and deploying it to a Windows 8 Enterprise device. If you just want to see the client experience jump to 5 minutes. The Deployment Sessions–001: Deploying a Windows Store App with Configuration Manager 2012 SP1 A few notes on the technical requirements to make this work, so you can try it out in your lab: You will need to download System Center Configuration Manager 2012 SP1 and have Windows Server 2012 to run it on.


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Kazmir mirrors Adenhart
Scott Kazmir was throwing the longest pre-game toss I've ever seen a few minutes ago, from the warning track in left center at Fenway Park all the way across the outfield to a spot about 40 feet from the right-field foul line.
Finishing his long toss, Kazmir threw some flat-ground deliveries and headed for the bullpen, casually tossing a ball into the crowd on his way.
The Angels' southpaw looked like a kid in the park, having a good time, which is how I would expect him to be. He loves this type of challenge, pitching on the big stage. If the Red Sox beat him in Game 3 of the American League Division Series, it won't have anything to do with Kazmir being intimidated by the crowd or the moment.
He's a pure-bred athlete, a former high school QB in Houston who simply loves to compete.
Among the many things I've grown to like about Kazmir is that he reminds me so much of Nick Adenhart. I was thinking about this on the long flight from LA to Boston. Those quiet moments alone are when I generally start thinking about Adenhart and the tragedy. I knew him and cared deeply about him, and it still hurts every day.
Kazmir didn't get to know Adenhart, which is a shame, because I'm sure they'd have become fast friends. On the other hand, it's possible Kazmir wouldn't be here if a drunken driver hadn't killed Adenhart, Courtney Stewart and Henry Pearson in the early hours of April 9.
It is entirely possible Adenhart, if not for that act of criminal insanity, would have been pitching Game 3 of this series.
Having uncovered some missing ingredients in his delivery, and recovering his confidence, which had sagged in 2008, Nick was just getting started in what would have been a breakout season when his life ended so prematurely at 22.
That's not just my opinion, that Adenhart had stardom in his future. Those who knew him best – teammates and especially catchers – are convinced he'd have had a big year, and then many more.
Kazmir is right there with you, in the moment, when you're talking with him. He's not somewhere else. He has that cool, easy manner that Nick embodied, an effortless grace that marks the premier athletes. Adenhart studied video of past greats and loved hearing stories about pitchers from previous eras. He laughed as I told him stories about some I've covered through the years, especially former Dodgers and A's star Bobby Welch. Welch was so much like Adenhart, and now we have Kazmir, too. It's comforting.
Kazmir's arrival on Aug. 28 changed the season for the Angels. It gave them a sense that they had everything they needed now. Veterans privately expressed shock that Tampa Bay would let a talent like this get away, and that the Angels would be lucky enough to land him through a waiver deal.
"This guy is really, really good," Bobby Abreu said that day. "I love that we got him. I've faced him – I know how tough he is. He is really going to help us."
John Lackey and Jered Weaver were brilliant in Anaheim, but this, of course, is a different venue. The Red Sox will feel the energy of the crowd, and if they regain their confidence, they can be dangerous.
The Angels have a cushion, but they are advised to do everything possible to finish off Boston today. You don't want the Red Sox gaining momentum and feeling good about themselves again.
6 Comments
Great post. Congrtulations to the Angels in one of the best games I have seen in the playoffs. Even though tbs had a bunch of red sox hommers anouncing the game it was nice to hear them suffer when the angels won. Also good job on cutting away from the angels celebration to show a re-run episode of singfield. It doesn't matter because angel nation is strong and I'm proud to be an Angels fan.
Congrats A's. All this season I've hoped that you'd go all the way… for Nick. Just keep it going! Kaz… we sure miss you.
What an amazing game. Somehow it was no surprise that when that door opened in the Green Monster, the Angels were able to walk right through. Miss you, Nick. You'll be in the hearts of Angels fans always. Wonderful post, Lyle – thank you. On to the next challenge …. 🙂
It was a crazy.. fabulous game.. which seems to be following the script for the '09 Post Season.
Dodger fan here. I clicked on this post and noticed the tag "bobby Welch" Ahh, one of my favorite back when. A nice gesture on his part back in the Summer of 1981, turned me into a Bobby Welch. Good memories that team with Mike Scioscia, another of my favorites.
I love the "About you."
ANGELS FAN SINCE 82…The first game i ever saw on TV, was an Angels game vs the mariners on channel 5 ktla, i still have a recording (somewhere in the garage) on VHS with commercials and everything . But all i wanted to say is that the Angels have come a long way, not just as a team but also with the quality of people the hire. I love the Angels and when the Angels are not playing or the season is over it feels like your child or spouse aren't around. Go Halos let's win this one for Nick,the fans,players and for Arte..he definately deserves to pop open the big bottle……..Retire #34 there's an Angels that going to wear that number for ever…plus a statue of Nick as you enter the stadium between the hats would be awsome.


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I thought this was a very interesting article to share, seeing as Orthopedics seems to have its share of controversies over research. It shall be interesting to see what the future holds in the field of research with him as head.
I was especially interested in Collins' comments on Science and Religion.
http://www.bloomberg.com/apps/news?p...v9Y&refer=homeScience and Religion
The study of the human genome has completely transformed medical research and is on the way to transforming clinical practice, Collins said in May, when he announced he would step down as head of the genome institute.
Collins grew up on a small farm in rural Virginia and was educated at home until the sixth grade. He received his undergraduate degree in chemistry from the University of Virginia, in Charlottesville, in 1970. He received his Yale doctorate in 1974 and a medical degree from the University of North Carolina, Chapel Hill, in 1977.
A guitar player known to be fond of motorcycles, Collins is also a one-time atheist who wrote a book in 2006 about his Christian beliefs. He took the title, The Language of God, from comments Clinton made at a 2000 ceremony, we are learning the language in which God created life.
God is most certainly not threatened by science, Collins wrote in the book. He made it all possible.


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You are formally invited to the Hoosier Beer Geek Third Anniversary Roundtable, to be held at Sun King Brewing on Saturday, August 22nd, at 6PM. As with any HBG event, the idea is to overwhelm, and we're currently doing our best to do just that.
We've got 100+ tickets for this event, and our goal is to sell them fast. So we're making a deal - the first 100 tickets will be $30. After those tickets are gone, we'll slowly increase the price until the day of the event.
Part of the idea behind the event is to help create a little buzz for Indy's newest brewery, Sun King. But we're also working with the friends we've made over the past three years to have beer from a wide variety of brewers and distributors. We've currently got commitments from our friends at Upland, Schlafly, Cavalier Distributing, and World Class Distributing.
In addition, we'll have various food options from Chef JJ - we're thinking small tastes that will match the beer selections. Of course the food is included with your ticket.
All of this is in the works, and it's still early. We plan to make this event as good or better than any other we've thrown, and we think it's safe to say that people rarely leave a HBG event disappointed. So buy now (or soon!), and share in the excitement with us as details roll in.
To buy tickets, click here.
And thanks for your patronage.
Jason, Jim, Mike, Matt, Gina, Rod, Chris, Jess, and Matt
The Hoosier Beer Geek Knights of the Beer Roundtable


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I found the KML widget for Flex viewer but I was not able to make it work properly. Can anybody have any link for that.
I came across SPOT and SWIPE tool code, but the links to download the code redirected to something else. I thing the links are dead. So any body have that code or widget for SPOT and SWIPE tool.
Thanks in advance


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Drag Race Use Only
Requires Specific Aftermarket Components
Case – Designed to utilize 9 1/2″ gear sets
Pinion Support – Ability to use 35 spline pinion gear
Housing – Additional clearance provided for 9 1/2″ ring gears
Will Not Fit OEM Cases or Housings
9 1/2″ Pro Gears will provide much longer gear life in comparison to 9″ Pro Gears
Life expectancy can increase by up to three times depending on the vehicle
The exception is when there is violent tire shake and the vehicle is kept under power
The ring gear is manufactured to 9 1/2″ specifications before the OD is reduced to 9.25″
Resulting in a much stronger tooth design than possible with 9″ Pro Gears
Machined From 9310 Forged Steel
Heat Treated to Optimize Material Properties
Matched Ring & Pinion Set
Ring Gear
– 9.25″ actual OD
– Tooth count 34
– 10 bolt holes in each bolt size
– 7/16″-20 RH threads & 1/2″-20 RH threads
– 35 spline shaft
– Tooth count 10
– 1″-14 RH threads
Unsure about your application?
Please contact a Strange Sales Associate to discuss your vehicle
Using Tapered Bearing Pinion Support
HD Pro & Drag race…….. R5238 / R5238WR
Ultra & Billet cases…. R5238UC / R5238UCR
Using Ball Bearing Pinion Support
HD Pro & Drag Race…… R5238B / R5238BR
Ultra & Billet cases… R5238UCB / R5238UCBR


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- About
- Details
- Postage & Returns
- Reviews
Simplicity, functionality and comfort come together to make the Gabbie S the goes-with-anything crossbody bag you've been crying out for. A main zipped compartment is supported by front and side zipped pockets, helping you stay ready for whatever the day might bring.
- Adjustable shoulder strap
- 2 Front zipped compartments
- Zipped main compartment contains:
- Zipped inner pocket
- Drop pocket for mobile phone
- Pen pocket
- Clipped key cord
- Two zipped side pockets
- Zipped rear compartment
- Kipling monkey key ring
- Size: 29 L x 22 H x 16.5 W cm
- Volume: 7 Litres
Want help with ordering or need more information? Can't see what you want? Call us! If Kipling have it, we can get it cheaper than anywhere else on-line!! Please contact us on 01637 876698 & we'll be happy to help!
How your item will be sent
Order before 3pm and your item will be dispatched the same working day. All orders will be posted FREE via Royal Mail 2nd Class (48 Hours) delivery. Fancy it quicker? Then select the 1st Class (24 Hour) option for only £2.99!
For shipping large items of luggage outside mainland UK, please contact us as an additional charge will be required.
Returns Policy
If you want to return your order within 14 days of having received your goods. A full refund will be issued if it is clear the products haven't been used or damaged in any way & in their original packaging. When returning items you will be responsible for them until they reach us. Postal costs incurred by yourselves will not be reimbursed.


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Penguins beat Senators for 7th straight win
Penguins 3, Senators 1
Tomas Vokoun made 34 saves and Dustin Jeffrey had a goal and an assist to lead the Pittsburgh Penguins to their seventh straight victory, 3-1 over the Ottawa Senators on Monday night.
Jarome Iginla and Tyler Kennedy also scored, and Brenden Morrow had two assists for the Penguins, who have already clinched first place in the Eastern Conference. Matt Cooke added an assist in his first game against Ottawa since his skate blade sliced the Achilles tendon of Senators defenseman Erik Karlsson on Feb 13.
Patrick Wiercioch scored and Craig Anderson stopped 21 shots for the Senators, who didn't get any help when Winnipeg beat Buffalo 2-1. The Jets now trail the Senators and New York Rangers by just a single point for the final playoff spot in the conference. Both the seventh-place Rangers and eighth-place Senators have a game in hand on Winnipeg.
The Penguins were without Sidney Crosby, Evgeni Malkin and Kris Letang because of injuries and illness, while No. 1 goalie Marc-Andre Fleury was back in Pittsburgh with his wife expecting their first child.
Although there was talk of revenge on Cooke for the Karlsson injury, not much came of it other than his refusal to fight Ottawa's Chris Neil in the opening minutes. The only rough treatment Cooke received was booing from the fans every time he touched the puck.
The Penguins jumped out to a quick 2-0 lead midway through the first period.
Jeffrey scored his third of the season off a one-timer at 6:15 following a cross-ice pass from Morrow, who then fed Iginla for his 13th of the season at 10:28.
While going behind the net, Morrow made a no-look pass in the opposite direction to Iginla in front as Anderson was moving away from the puck, giving Iginla an open net to shoot at.
Following a penalty-filled opening period, the Senators started the second with fresh ice and nearly a full two minutes of power-play time but were unable to register a single shot on Vokoun, who was playing in his 700th career game and recorded his 300th win.
The win was also the 200th in the NHL for Penguins coach Dan Bylsma.
Notes: Karlsson is back practicing with the Senators and could return to the lineup before the end of the regular season. ... The Penguins were first in the NHL with 3.34 goals per game heading into Monday. The Senators were second in goals against, allowing just 2.09 per game, just slightly more than Chicago. ... The Penguins (19-0-0) are one of just three teams (Rangers, Blue Jackets) that have not lost a game this season when leading after two periods. ... The Penguins are 22-3 against the seven other East teams currently occupying a playoff position. ... Crosby continues to lead the NHL in scoring despite having played nine fewer games than his closest pursuer. ... Senators D Chris Phillips is one assist shy of 200 for his career.


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North announced the 2014 release of their best-selling kite, the Rebel, this week calling it a "High Performance Freeride" kite. We're looking forward to testing their latest innovations on the water. In the meanwhile, read below to hear what North designer Ken Winner has to say about this year's model.
The Rebel was a game changer when it was first launched and since then it has remained the best selling kite in the North Kiteboarding range year on year. There are so many fans out there that fly the Rebel week in week out and love it. With good reason, the Rebel is one of the most stable kites on the market, making it perfect for beginners, intermediates and experts alike. The kite offers responsive steering, even when it is depowered. The upwind ability of the kite is also fantastic, making it great for freeride, waves and even a bit of racing.
The Rebel gives the rider a good amount of bar feedback, offering total control in the roughest conditions. The hangtime and lift offered by the kite is amazing, huge floaty jumps are delivered time and time again. This year the kite has a deeper profile, which allows it to drift a little more in the waves but also offers an improved low end. Sky Solbach, NKB surfboard shaper, uses the Rebel when he is testing in Maui and Western Australia and relies on its dependable handling characteristics in all conditions to allow him to concentrate on the boards under his feet.
Strut Construction 3D:
The Struts have been refined with a semi-segmented construction. The segments allow the struts to mimic the shape of the profile, which helps to avoid stress points. The design is very lightweight but also precise, which increases the structural rigidity.
New Panel Layout "Force Spread":
Compared to 2013, the layer of wave-shaped cloth situated at the boundary between the durable 50-gram D2 Ripstop Canopy and the super tough 160-gram trailing edge dacron is put higher and wider to eliminate stress points between the two materials. This change in construction leads to a better mitigation of flutter and flexing between the dissimilar materials.
Deeper Profile:
In 2014, the Rebel has a slightly deeper and more draft forward profile, which gives the kite a more positive upstroke and smoother transit through the centre of the wind window.
Size Specific Tuning:
The Rebel has been a competitive kite in racing with super lowend and excellent upwind ability. Besides, within the North Kiteboarding line up the Rebel has the best windrange together with the race kite Dyno. Today you could virtually say the Rebel is developing into two different directions.
Developer Perspective
Ken: The bigger size Rebels 14 / 13 / 12 and 11 are characterized by the following performance properties:
- Super lowend
- Massive hangtime and jumping abilities
- Good upwind performance
- Sheet and go
Based on these properties in the bigger sizes, the Rebel is an absolutely freeride-oriented kite.
Rider Perspective
Sky: The Rebel 2014 in smaller sizes, talking about size 10 to 5, is my favourite kite when I go wave riding. Mentioning below just some of its performance properties which are essential for waveriding:
- Enormous depower ability
- Smooth turning
- A lot of power, which is especially interesting for heavier kiters
- Stable and solid feel
- Good drift (the kite does not fly as quickly to the edge of the wind window which permits to more readily drift downwind)
Summarizing, due to the diverse characteristics the new rebel can be described as a high performance freeride / wave kite.


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Only if you consider ACR a "subpar" RAW converter. And you're not necessarily limited to ACR; any RAW converter that can export to linear-RGB DNG can be used for demosaicing. The majority of the lens corrections have to be done on demosaiced RGB data; for example, CA corrections (which involve shifting the locations of color channels relative to each other) cannot be saved back to RAW because the pixel locations no longer match the Bayer matrix pattern. Correcting barrel/fisheye distortion has the same problem, only worse because the degree of pixel-shifting es even greater.It just makes sense to demosaic first, and then apply corrections and adjustments.
Hi Sandy, yes, you are right: the DNG SDK only has a simple bilinear interpolation demosaic routine implemented. (We have been meaning to update it with something more serviceable, but have not worked that into the already rather-packed dev schedule ...)
The testing I've done indicates that opening a linear-RGB DNG (demosaiced in DNG converter) and processing the source RAW directly in ACR makes zero difference
Actually, CA correction can be done, and done better, during demosaic rather than after.http://www.ojodigital.com/foro/perfectraw-...erpolacion.html
The samples in that thread didn't look that impressive to me; in the side-by-side comparison of the makeup brushes, AMAZE didn't appear to do as well as the other converter it was compared to. Correcting CA during demosaic may not be worse than doing so after, but I didn't see any proof it's significantly better.
All of the internal correction operations are done on linear RGB data in the camera's native color space, so that setting white balance, selection of color profile, etc. is unaffected by the image correction operation. The user will have the exact same color processing options, ability to select white balance, exposure adjustments, and output color space selection as when working with the original RAW(s).
The side-by-side with the brushes is a comparison to AMaZE prior to CA correction, the CA corrected version is lower down in the thread (post #11). Here's a direct comparison with ACR at 400% (using a different image). I set the ACR 4.6 CA correction slider so as to minimize CA artifacting in the blinds (there was no setting that eliminated it altogether), and it still crops up in the church steeple and the tree limbs/branches. Anyway, regardless of the specific implementation, it seems to me that any geometric correction that can be applied in a linear space such as RAW is better done there rather than after the nonlinear operation of demosaic. For instance, CA can corrupt the demosaic process itself, depending on the algorithm used (cf the HPHD examples from RawTherapee in the Ojodigital thread).
I'm still not convinced that correcting CA during demosaic is the magic bullet you think it is. Other than the CA, the differences in the conversions were minimal, mostly due to slightly different tone curve or exposure settings.
The problem with ACR and most every other RAW converter's CA correction is that it's using a fairly simple mathematical formula (something along the lines of a simple gamma curve) to calculate the pixel shift distance needed to realign the color channels and correct the CA. The problem is that this formula is an approximation many lenses do not follow very well; therefore for many lenses there is no setting that creates the proper curve to correct the CA completely. The best you can do is spread the error fairly evenly so that no part of the image looks too horrible. The approach I'm using creates 3 spline curves with 32-64 data points each (calculated separately for each color channel) so that the color channels can be aligned to within 1/10 of a pixel or so from the center of the image all the way to the corners, regardless of whether the lens' distortion curve is simple or extremely complex.
Jon, if I understood well you plan to demosaic the RAW data with the DNG routines, and that means you should apply white balance first. You can demosaic with no WB applied, but this will probably affect the efficiency of the demosaic process in terms of getting right colours and detail.
BTW if you would like any advice on how to blend different RAW files (relative exposure calculation, and minimal progresiveness blending) feel free to ask.
Actually it doesn't. If you export a linear-RGB DNG from DNG Converter or Bridge, and then process that DNG and the original RAW file in ACR with the same settings, the result is a pixel-for-pixel match, and you have exactly the same flexibility for setting exposure, white balance, and color adjustments either way.
Thank you. Would you be interested in perhaps combining our projects, to create one DNG processing tool that does everything?
But how do you use Bridge to demosaic a non white balanced RAW file?
Bridge can run ACR directly w/o PS
But how do you use Bridge to demosaic a non white balanced RAW file?At least using DCRAW, the AHD algorithm works quite differently if applied on white balanced RAW data than when used on non white balanced data. Colour artifacts and differently interpolated detail appears when the RAW values are not balanced, surely Emil can explain why these issues happen:White balance prior to demosaicing:http://www.guillermoluijk.com/tutorial/dcr...tefactoswb1.jpgWhite balance after demosaicing:http://www.guillermoluijk.com/tutorial/dcr...tefactoswb2.jpg
I know, but it allows not to white balance the RAW file? and it allows not to convert to an output colour profile?My ACR doesn't.
In the particular case of AHD, the interpolation uses color differences G-R and G-B; while the white balance is a multiplicative shift G -> G, B -> c*B. Typical scenes with not a lot of saturation, G-B is smoothly varying and small in amplitude (it is akin to the Cb channel of YCrCb color space). If the data is not white balanced, then AHD is interpolating RAW data with chromaticity G-B/c. If c is large and G~B ie approximately gray, AHD is trying to interpolate data that looks to it as though the chromaticity is very large and rapidly varying across edges. Of course it's all fake but AHD doesn't know that, and so its errors have large (fake) chromatic content along edges, that persists when the white balance is finally done after demosaic. It ultimately traces to the mismatch between chromaticity being additive while white balance is multiplicative. The order of operations matters when considering error propagation.That's why, again, it's best to do as many corrections as possible while the data is in a linear space, ie prior to demosaic. Though I imagine Jonathan remains unconvinced.
Just a clarity on terminology first: By white balance I understand that only the primaries are adjusted and no cross-term multiplication happens yet (as in a color correction matrix).
White balance as I'm using the term is just multiplying all linear color channel values by a fixed value (all B values by 1.105 and all R values by 1.027, for example).
Obviously, ACR is using an algorithm far less stupid than what you are describing; the proof is in the DNGs in my previous post. A strategy needed to work around a limitation imposed by one particular stupid demosaic algorithm does not generalize to iron-clad proof that the work-around is necessary or even desirable in all cases for all demosaic algorithms. Look at the reflection of the umbrella in the baby's right eye. There's a small amount of CA visible. It is fixable with the lens correction sliders in ACR set at about -5,+7. The correction is equally effective in both versions of the DNG, even though the linear version has demosaicing done before white balancing. If your argument was valid, the Bayer version would be more correctable than the linear RGB version of the DNG.


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In a world that grows more complex every day, wouldn't it be a welcome change to have just one thing become a little simpler? Well, when it comes to busy family physicians managing their patients' hypertension, a newly released guideline could go a long way toward accomplishing that goal.
"2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8),(jama.jamanetwork.com)" published online Dec. 18 by JAMA: The Journal of the American Medical Association, outlines nine specific recommendations for initiating and modifying pharmacotherapy for patients with elevated blood pressure (BP).
According to lead author and family physician Paul James, M.D., of Iowa City, Iowa, rather than tackle the entire panoply of what is known or assumed about diagnosing and treating hypertension, the diverse group of members appointed to the guideline panel by the National Heart, Lung and Blood Institute (NHLBI) in 2008 focused instead on answering three key questions:
Story highlights
- A new evidence-based guideline outlines nine specific recommendations for initiating and modifying pharmacotherapy for patients with elevated blood pressure (BP).
- Among those recommendations is one stating that, in general, patients 60 and older should start treatment to lower BP at a systolic blood pressure of 150 mmHg or higher or a diastolic blood pressure of 90 mmHg or higher and treat to below those thresholds.
- The guideline also outlines which medications are best for specific patient populations based on factors such as age, race and health status.
- In adults with hypertension, does initiating antihypertensive pharmacologic therapy at specific BP thresholds improve health outcomes?
- In adults with hypertension, does treatment with antihypertensive pharmacologic therapy to a specified BP goal lead to improvements in health outcomes?
- In adults with hypertension, do various antihypertensive drugs or drug classes differ in comparative benefits and harms on specific health outcomes?
"So, it's really, 'At what BP do you start medication?' and then, 'At what BP do you maintain medication?'" James said in an interview with AAFP News Now. "And then the third question was, 'What are the medications (or antihypertensive drugs) that doctors should use to get to goal?'
"We considered these the three most important questions that any doctor in America needs to know the answer to."
From the outset, the panel committed to following the pathway to guideline development outlined in the Institute of Medicine report Clinical Guidelines We Can Trust. This approach entailed using rigorous evidence-based methods to develop evidence statements and recommendations for BP treatment based on a systematic review of the literature, while focusing on meeting guideline user needs, especially the needs of primary care clinicians.
Overview of Guideline's Recommendations
The evidence review and summarization was performed by an external methodology team panel and focused on studies that examined adults 18 or older with hypertension, including studies that involved numerous prespecified subgroups, such as patients with diabetes, coronary artery disease, previous stroke and chronic kidney disease (CKD). Studies that focused on older adults also were included, as were those that examined both men and women, various racial and ethnic groups, and smokers.
The guideline panel chose to review only randomized controlled trials (RCTs) involving at least 100 subjects "because they are less subject to bias than other study designs and represent the gold standard for determining efficacy and effectiveness," the authors wrote.
Although panel members attempted to reach consensus on all recommendations, a two-thirds majority was considered acceptable, with the exception of recommendations for which no RCT evidence was eligible for review. For these areas, recommendations were based on expert opinion and required approval by 75 percent of panel participants.
A condensed version of the guideline's nine recommendations follows. Details of the strength of evidence grading system the panel used are discussed in an online supplement(jama.jamanetwork.com) to the guideline.
- In the general population ages 60 and older, pharmacologic treatment to lower BP should be initiated at a systolic blood pressure (SBP) of 150 mmHg or higher or a diastolic blood pressure (DBP) of 90 mmHg or higher. Patients should be treated to a goal SBP lower than 150 mmHg and a goal DBP lower than 90 mmHg. If treatment results in lower achieved SBP and is not associated with adverse effects, treatment does not need to be adjusted.
- In the general population younger than age 60, initiate pharmacologic treatment at a DBP of 90 mmHg or higher or an SBP of 140 mmHg or higher and treat to goals below these respective thresholds.
- In the population ages 18 years or older with diabetes or CKD, initiate pharmacologic treatment at an SBP of 140 mmHg or higher or a DBP of 90 mmHg or higher and treat to goals below these respective thresholds.
- In the general nonblack population, including those with diabetes, initial treatment should include a thiazide-type diuretic, calcium channel blocker (CCB), angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB).
- In the general black population, including those with diabetes, initial treatment should include a thiazide-type diuretic or a CCB.
- In the population ages 18 or older with CKD and hypertension, initial (or add-on) treatment should include an ACE inhibitor or an ARB to improve kidney outcomes. This applies to all patients in this population regardless of race or diabetes status.
- Finally, the main objective of hypertension treatment is to attain and maintain goal BP. If goal BP is not reached within a month of initiating treatment, increase the dose of the initial drug or add a second drug from one of these four classes. The clinician should continue to assess BP and adjust the treatment regimen until goal BP is reached. If goal BP cannot be reached with two drugs, add and titrate a third drug from the list provided.
This final recommendation includes a caveat that ACE inhibitors and ARBs should not be used concomitantly. If goal BP cannot be reached using the above-named drugs because of a contraindication or the need to use more than three such drugs to reach goal BP, antihypertensive drugs from other classes may be used.
Referral may be indicated for patients in whom goal BP cannot be reached using the above strategy or to manage complicated patients for whom additional clinical consultation is needed.
Takeaways for Family Physicians
According to James, the chief message to family physicians is that the new guideline stands to simplify the management of high blood pressure in their patients.
"No. 1, it's going to simplify the goals (of treatment because) there are only two goals to remember. No. 2, I do think a lot of physicians who take care of the elderly have been concerned over the years about the potential for causing harm by overtreating blood pressure." It's certainly not uncommon for elderly patients to become dizzy on standing because of the antihypertensive medication or medications they take. Such patients, James noted, are at an increased risk for falls and their sequelae.
From that perspective alone, he noted, "I think many people who take care of the very elderly will think these guidelines make more sense."
Overall, "I think we've simplified the drug regimen for family doctors," said James, although certain aspects of the new guideline may have some clinicians doing a double-take, he acknowledged.
"One thing that family doctors may not realize is that beta blockers, which are a tried-and-true and beloved medication for treating high blood pressure, actually got pushed down to the second tier. That may come as a surprise to many of them."
Admittedly, the release of the 2014 guideline likely will raise some eyebrows, and not just for its content. Unlike past guidelines developed by expert panels convened by the NHLBI, the new guidance document was not endorsed by any government agency or professional organization before publication. That's because in the face of a controversial decision NHLBI officials made in June that would have delayed publication of the long-awaited guideline, the authors decided to pursue publication independently, a fact they address in the guideline itself.
But that's really not germane to the important conversation that now needs to take place, said James. "The science part of this is the part I want people to focus on now.
"One of the things I'm hoping is that groups like the Academy and the American College of Physicians would look at the process (we used) and see that it's very different from other guidelines and that it had very active participation by primary care doctors."
That process already has begun.
"The report from the JNC 8 panelists is among the most anticipated guidelines of the past several years and addresses a top priority topic for family physicians and their patients," said Steven Brown, M.D., of Phoenix, chair of the AAFP Commission on Health of the Public and Science.
"The AAFP will make an official decision about endorsement within the next few months after review of the guideline using our rigorous endorsement methodology."
That said, Brown added, "On initial review, there seem to be substantial improvements in the approach of the guideline panel, in accordance with the Institute of Medicine's 2011 recommendations on how to write 'Clinical Guidelines We Can Trust.'(www.iom.edu)
"Major improvements in the approach used by JNC 8 panel members include
- restricting decision-making to evidence from systematic reviews of randomized controlled trials with patient-oriented outcomes;
- providing a strength of recommendation and level of evidence for all recommendations, and, when there is limited evidence on which to base recommendations, the guideline panel clearly states recommendations are based on expert opinion;
- involving a diverse group of clinicians, including primary care physicians and experts in evidence-based medicine; and
- limiting the focus of the review to the most important questions facing physicians and their patients, as well as clearly communicating a reasonable number of recommendations."
For his part, James welcomes the scrutiny.
"My belief is that this is going to cause a significant debate, and my impression is that groups like the Academy are going to engage in that debate about what is the best way to develop guidelines; how can we be sure that we don't wind up with guidelines that are just focused and run by one specialty organization; and how can we be sure that we have the right people developing these who we respect and who are really looking out for the best interests of our patients."
Additional Resources
JAMA Editorial: "Assessing the Trustworthiness of the Guideline for Management of High Blood Pressure in Adults"(jama.jamanetwork.com)
(Dec. 18, 2013)
JAMA Editorial: "Recommendations for Treating Hypertension: What Are the Right Goals and Purposes?"(jama.jamanetwork.com)
(Dec. 18, 2013)
JAMA Editorial: "Updated Guidelines for Management of High Blood Pressure: Recommendations, Review, and Responsibility"(jama.jamanetwork.com)
(Dec. 18, 2013)
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COLUMBUS, Ohio (AP) -- An Ohio judge has allowed veterans and fraternal posts to continue operating electronic raffle machines while a lawsuit by the groups against the state attorney general proceeds.
While a portion of the raffles' proceeds go to charity, Attorney General Mike DeWine has declared the devices to be illegal, and after months of enforcement delay ordered them shut down in October.
The Columbus Dispatch reports (http://bit.ly/1joY7ZZ ) that Franklin County Judge Laurel Beatty's order on Thursday prevents DeWine, the Ohio Liquor Control Commission and any cooperating agency from taking enforcement action against the machines.
Beatty's order came the same day lawyers for groups operating the machines argued in a lawsuit against DeWine that the devices are legal and posts and lodges shouldn't be subject to criminal or civil penalties.
Information from: The Columbus Dispatch, http://www.dispatch.com


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U.S. Equal Employment Opportunity Commission (EEOC)
EEOC Sues AutoZone for Fourth Time for Violating Americans with Disabilities Act
Federal Agency Charges Giant Auto Parts Retailer Failed to Accommodate Disability-Related Absences of Employees, Retaliated Against Employee for Protesting
CHICAGO - AutoZone, Inc. violated federal law when it implemented a nationwide attendance policy that failed to accommodate certain disability-related absences, the U.S. Equal Employment Opportunity Commission (EEOC) charged in its fourth disability lawsuit in recent years against the giant auto parts retailer which the agency filed here today.
According to the EEOC's complaint, from 2009 till at least 2011, AutoZone assessed employees nationwide "points" for absences, without permitting any general exception for disability-related absences. Twelve points resulted in an employee's termination. As a result, qualified employees with disabilities with even modest numbers of disability-related absences were fired, the complaint alleges. This included, for example, an Ottawa, Ill. employee with Type 2 diabetes who had to leave work early occasionally because of insulin reactions and who was fired because of the resulting attendance points. The complaint also claims that another employee was discharged in retaliation for objecting to the attendance policy and filing a charge with the EEOC.
The EEOC brought the suit under Title I of the Americans with Disabilities Act (ADA), which prohibits disability discrimination in employment, and under Title V of the ADA, which bars retaliation for reporting such discrimination. The EEOC filed suit after first attempting to reach a pre-litigation settlement through its conciliation process. The case, (EEOC v. AutoZone, Inc., Civil Action No. 14-cv- 3855) was filed in U.S. District Court for the Northern District of Illinois, Eastern Division, and was designated and assigned to U.S. District Judge Marovich. The government's litigation effort will be led by EEOC Supervisory Trial Attorney Gregory Gochanour and Trial Attorney Justin Mulaire.
The case is the fourth disability discrimination case against AutoZone litigated by the EEOC in recent years. In 2009, a consent decree was entered resolving an EEOC claim that AutoZone had failed to promote a visually impaired employee in Cottonwood, Ariz., and denied him permission to use a guide dog (EEOC v. AutoZone, Inc., Case No. CV-06-1767 (D.Ariz.)). That decree awarded the employee $140,000 and required the company to conduct training about the ADA in all of its Arizona stores. In another case, a central Illinois jury found in 2011 that the company refused to accommodate a sales manager's disability by insisting that he mop floors, leading to further injury. (EEOC v. AutoZone, Inc.Case No. 07-cv-1154 (C.D.Ill.)). That case resulted in a $424,000 judgment against AutoZone, which was affirmed on appeal. In 2012, the agency filed a third disability suit against the company, charging that it refused to accommodate the lifting restriction of a disabled employee at its Cudahy, Wis., store, and fired her instead (EEOC v. AutoZone, Inc., Case No. 12-cv-303 (E.D.Wis.)). The court recently ruled that the claims in that case will proceed to trial.
"The obligation to provide reasonable accommodations for qualified individuals with disabilities has been the law of the land for over two decades, and businesses large and small, operating coast to coast have found ways to bring their operations into compliance with the law," said John Hendrickson, regional attorney for the EEOC's Chicago District. "So it is especially disappointing any time a huge national employer with tens of thousands of employees repeatedly engages in unlawful discrimination against individuals with disabilities and declines to share responsibility for maintaining a level playing field for disabled American workers. In those cases, the EEOC is ready to litigate, repeatedly if necessary, to assure that no employer-no matter how big-can continue to believe that somehow the ADA does not apply to it."
On its website, Memphis-based AutoZone traces its history to a single store opened in 1979 in Arkansas under the "Auto Shack" name. The company says that it is now "a Fortune 500 company and the leading auto parts retailer in the United States with more than $8.1 billion in annual sales." The company states that it does business in 48 states, has more than 65,000 employees, and "continues to fuel growth by exploring news businesses and entering new markets."
The EEOC's Chicago District Office is responsible for processing discrimination charges, administrative enforcement, and the conduct of agency litigation in Illinois, Minnesota, Wisconsin, Iowa, North Dakota and South Dakota, with Area Offices in Milwaukee and Minneapolis.
The EEOC enforces federal laws prohibiting employment discrimination. Further information about the EEOC is available on its website at www.eeoc.gov.
http://www.eeoc.gov/eeoc/newsroom/release/5-9-14a.cfmFor more from U.S. Equal Employment Opportunity Commission (EEOC) visit: