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Sid Meier Bringing Civilization to Facebook
"Civilization Network will allow you to join together with your friends to create the world's most powerful, richest, smartest, or just plain coolest civilization," wrote Meier in announcing the game on the Civ Fanatic's forum.
Meier described the gameplay briefly, saying: "You can coordinate your strategy to win great battles, share your technology to jump ahead of your rivals, lobby your family and friends to form your own government and win vital elections, manage and grow your cities to maximize production and happiness, spy on your enemies, and work with your friends to create the great Wonders of the World."
The persistent game will be free to play, and will enter a beta testing period before launching in 2010. More information will be posted on the game's Facebook page.


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The little number you see up top — titled "Chart of comets, star clusters and nebula" — was engraved in 1856 by one W. G. Evans for Burritt's Atlas to Illustrate the Geography of the Heavens.
I'd say it makes for a pretty cool little collection of vintage space porn, but don't take my word for it; apparently, it was none other than Geography of the Heavens that first piqued H.P. Lovecraft's fascination with astronomy. In a letter to Maurice W. Moe in 1915, Lovecraft wrote:
My maternal grandmother, who died when I was six, was a devoted lover of astronomy, having made that a specialty at Lapham Seminary, where she was educated; and though she never personally showed me the beauties of the skies, it is to her excellent but somewhat obsolete collection of astronomical books that I owe my affection for celestial science. Her copy of Burritt's Geography of the Heavens is today the most prized volume in my library.
Don't miss the spitting image of Halley's comet down at the bottom of the full-size image.
[Spotted on Scientific Illustration]


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Two Elephants Pill Organizer with Divided Compartments - $11.99 with FREE shipping!
You're good when it comes to remembering when to pick up the dry cleaners, when to make that hair appointment, or when your favorite TV show comes on, but when the time comes to take your daily medications? Not so much. That's why we're offering you a great way to be relaxed and organized with your everyday pills. Our Weekly Pop-Up Pill Organizer with Divided Compartments contains 7 individual removable pill organizers for each day of the week. They pop up once you unlock the top thanks to the spring at the bottom. Each organizer has 4 divided compartments for morning, noon, evening, and bedtime. With a organizing system as easy as this, you won't ever forget to take your medication ever again!Highlights


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Vancouver has had a number of acts come through of late whose onstage gymnastics would be impressive for people half their age. Think Bruce Springsteen crowd-surfing at age 63; 70-year-old Paul McCartney belting out hits for three hours with nary a break or even a drink of water; or 54-year-old Madonna singing and dancing for two-plus hours.
The rockers' workouts vary, but their diets have one thing in common: They are all vegetarian or mainly vegetarian.


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Every August, the National Aquarium invites our members and the general public to join us on shark research trips We work with Captain Mark Sampson to collect data from several species of sharks off of our Maryland coastline for a variety of ongoing research projects. Trip participants actively engage in catching the sharks, reeling them in, measuring them once on the boat, and tagging and releasing them. It's a once-in-a lifetime experience that provides valuable species and population data for several researchers around the country and exciting educational experiences for participants.
Captain Sampson works with several researchers to study the migratory patterns, growth rates, population data and species data of the sharks he catches. Every shark that is brought on board is measured and its sex determined. The data and location is noted and a small piece of dorsal fin is clipped and preserved for DNA analysis. Each shark is also given in injection of oxytetracycline, an antibiotic that stains the vertebrae and provides a baseline for growth data if the shark is ever recaptured. Finally, if the shark is big enough, it is tagged.
This tagging is part of the National Marine Fisheries Service (NMFS) Cooperative Shark Tagging Program. This program, started in 1962 was developed to provide information on the life histories and migratory patterns of Atlantic sharks. According to NMFS, between 1962-2010, over 221,000 sharks of 52 species have been tagged and more than 13,000 sharks of 33 species have been recaptured. Distances traveled for the 33 species ranged from no movement to 3,997 nautical miles (nm) (blue shark). The longest time at liberty for any shark in the program is 27.8 years (sandbar shark).
Our team took eight trips with Captain Sampson in August and caught 48 sharks total! The species tagged included sandbar, dusky, spinner, Atlantic sharpnose and smooth dogfish.
It's obvious to anyone that steps aboard his vessel that Captain Sampson has a great respect for these animals and is passionate about conserving shark populations through research and education! If this sounds like something you'd be interested in, check back with us next Spring for our 2014 shark tagging trip dates.
In the meantime, there are several things you can do right now to protect the sharks off our coast and worldwide. Please make sure you are choosing seafood that caught without harming sharks and do your part to help keep our oceans clean.
Hope to see you on the boat next August!


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Madden NFL 10 (Wii) review
"EA Sports may have dropped the All-Play subtitle from its Wii lineup, but it hasn't abandoned the All-Play attitude. In fact, Madden NFL 10 only further embraces the casual concept. Here's the clincher. Franchise Mode, the staple of the single-player experience, has been relegated to an unlockable, accessible only with a secret code."
Staff review by Benjamin Woodhouse (September 01, 2009)
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Chances are, if you are visiting Australia (or even New Zealand really) you will be flying in/out of the Sydney airport. Dan and I flew into and out of Sydney 6 times while we were traveling in Australia and New Zealand. Australia's biggest city also has the country's biggest and busiest airport. But what's the best way to get to and from Sydney's airport when you are traveling on a budget?
The only options for getting to or from this airport are a taxi (expensive), the train, or the only city bus that goes to the airport, bus #400 from Bondi Junction. The bus is definitely the cheapest option, but it only really works if you are coming from Bondi Junction. If you happen to be staying around there, by all means take the bus, but for everyone else, going all the way out to Bondi Junction to get on a bus for over an hour just seems crazy. Plus there is a better way to save yourself some money while getting to the airport.
In my opinion, the most obvious travel option to the airport is the train. It is definitely fast; only 15 minutes from the center of Sydney. But there is a catch when traveling by train to Sydney's airport. There is a special gate fee for exiting at both the domestic and international terminal train stations. The story goes that the reason for these fees is because before the 2000 olympics, the government wanted to add an easier way to get to the airport than the bus. They hired a private company to build the airport link – a 4-stop detour on the green line – and the private company decided to charge gate fees on all 4 of it's stations to recoup their investment. I'm going to assume that the local community complained about their suburban stations costing substantially more than nearby stations, because eventually the extra charges were removed from the suburban stations. But not from the 2 airport train stations!
Additional fees to get to the airport aren't new. You find them at most major airports. Here in New York City you can get to JFK International Airport on the subway – it will only cost you $2.50 – but to actually get to the terminals you have to pay to take the AirTrain. That will set you back an additional $5. So $7.50 total to get from anywhere in NYC to any terminal at JFK International. The gate fee to exit at Sydney's airport terminals is $12.60 AUD ($11.42 USD). That's on top of the $3.80 to $4.60 AUD ($3.44 to $4.17 USD) that the train trip out to that neck of the woods costs. This means that to get off of the train the stop before the domestic terminal costs $3.80 AUD ($3.44 USD) from city center, but to get off at the domestic airport terminal costs $16.40 AUD ($14.86 USD). The international terminal is a bit farther away (Sydney prices their stops by distance), so from city center it will cost you $16.40 to $17.20 AUD ($14.86 to $15.59 USD). And to get to the stop after the international terminal? That only costs $3.80 to $4.60 AUD ($3.44 to $4.17 USD). Dan and I weren't having that so we thought let's see if we can circumnavigate the system.
Turns out, it isn't really that hard. Both trips are flat and right around a mile from the train station to the terminal. This is the beauty of traveling light. Throughout the trip I kept saying that we have time but not so much money. Well if you are in the same boat, I highly recommend walking!
To get to the Domestic Terminal:
Get off the train at Mascot. This will cost you $3.80 AUD from Sydney CBD. Walk south on Bourke Road. Continue south on O'Riordan Street. The entrance to the domestic terminal will be obvious! This walk is more straight forward than the walk to the international terminal. This is really easy! Totally worth doing if you have an extra 20 minutes and aren't dragging a big, heavy rolling bag behind you.
To get to the International Terminal:
This one is a bit more complicated, but there is at least one sign (see above)! Take the train to Wolli Creek. This will cost you $3.80 to $4.60 AUD from Sydney CBD. When you exit, walk down Brodie Spark Drive. At the end of the drive you will see a park along a river's edge across the street. Cross the street and walk in the park along the river's edge. Stay along the river's edge until you have to bear right to make sure you can get on the walkway along the bridge that crosses the river. Cross the river. On the other side you will see the sign in the picture above. Follow the sign and cross under the overpass. Keep to the left for a few minutes until you see the international terminal on your right. This walk includes a park! Totally worth it before a long international flight.
I hope this tutorial will encourage you, brave readers, to consider sticking it to the man and saving yourselves a few bucks before your flight out of Sydney. Travel safely!


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Wednesday, October 18, 2017
7:30 a.m.
LocationEagle College Preparatory
A key component of Valley Metro's Construction Outreach Program for the Gilbert Road Extension is the formation of a citizen board to serve as the voices for the community during light rail construction. The board is known as the Community Advisory Board (CAB) and is comprised of residents and business representatives from the community adjacent to the light rail route.
The role of CAB members is to review and evaluate the performance of Valley Metro's contractor as it relates to minimizing impacts to the community. CAB members will make a recommendation to Valley Metro whether to award a quarterly incentive to the contractor for going 'above and beyond' Valley Metro's contract specifications.
The meeting is open to the public and there will be a call to the audience for comments.


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Create a Ning Network!
Celebrate the culture of agriculture & share skills (Growing! Cooking! Eating!)
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Why Backyard Chickens Are Thriving During COVID-19
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The Race for Family Farms on June 28
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Time is the longest distance between two places.
Tennessee Williams
Since I started this site several years ago, I've been determined to maintain seven daily posts, seven days a week. Every so often, I'd miss a day, and I would take a few days off here and there, but, overall, I've been dedicated. Except lately. Lately, I've not been able to keep up with it, and, when I have, it's been repeats.
Time has not been my friend of late.
So, since my schedule has been overwhelming, and will continue to be for the next few weeks, I should just accept that posting may be spotty for awhile. I apologize for that. When I can, I'll get a few interesting articles up and I have a backlog of "Treats of the Week" for you.
Keep coming back. I promise I'll get my act together soon.
Time permitting.


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link: "https://www.loc.gov/pictures/item/lbb1540/",
url :"//cdn.loc.gov/service/pnp/ppmscd/00400/00422_150px.jpg",
alt:'Image from Prints and Photographs Online Catalog -- The Library of Congress'
Larger images display only at the Library of Congress
JPEG(63kb) | JPEG(315kb) | TIFF(19.2mb)
- - Browse neighboring items by call number.
- Collection: Look Collection
Digital display record: This record exists solely to make the digital image available. You may be able to learn more about the Look Magazine photograph job related to this picture by searching for the record describing the whole job, for example "LOOK - Job 60-8632".
- Title: [Digital display record: This record exists solely to make the digital image available. You may be able to learn more about the Look Magazine photograph job related to this picture by searching for the record describing the whole job, for example "LOOK - Job 60-8632".]
- Reproduction Number: LC-DIG-ppmscd-00422 (digital file from original)
- Rights Advisory:
Publication may be restricted. For information, see "Look Magazine Photograph Collection Rights and Restridctions Information" (http://www.loc.gov/rr/print/res/074_look.html)
- Call Number: LC-L9-70-5679-G, no. 4-4A [P&P] LOOK - Job 70-5679
- Repository: Library of Congress Prints and Photographs Division, Washington, DC 20540 USA
- Collections:
- Bookmark This Record:
View the MARC Record for this item.
The Library of Congress generally does not own rights to material in its collections and, therefore, cannot grant or deny permission to publish or otherwise distribute the material. For further rights information, see "Rights Information" below and the Rights and Restrictions Information page ( http://www.loc.gov/rr/print/res/rights.html ).
- Rights Advisory: Publication may be restricted. For information, see "Look Magazine Photograph Collection Rights and Restridctions Information" (http://www.loc.gov/rr/print/res/074_look.html)
- Reproduction Number: LC-DIG-ppmscd-00422 (digital file from original)
- Call Number: LC-L9-70-5679-G, no. 4-4A [P&P] LOOK - Job 70-5679
Generally, Look Collection photographs have been described in groups. Look at the Medium field above. If it lists more than one item, select images for reproduction through one of these methods:
- Check for digital images: In a small number of cases, selected images from a job have been digitized and display online:
- Copy the information in the Call Number field above (e.g., LOOK - Job 54-2946)
- Go to the Prints & Photographs Online Catalog home page, and enter the Call Number in the "Search All" blank and press "Go"
- If a desired image displays you can download it yourself. (Most images display only as thumbnails outside the Library of Congress because of rights considerations, but you have access to larger size images on site.) Alternatively, you can purchase a copy through Library of Congress Duplication Services by citing the identifying information under the image (e.g., http://hdl.loc.gov/loc.pnp/ppmsca.12333)
- OR view materials in the Prints & Photographs Reading Room. If the Medium field lists unpublished color images or negatives, advance arrangements must be made to view them -- see: http://www.loc.gov/rr/print/info/022_unpr.html
- OR Prints & Photographs Reading Room staff can provide up to 10 quick copies of contact sheets per calendar year. For assistance, see our Ask a Librarian page
- OR hire a freelance researcher to do further selection for you (a list of researchers is available at: http://www.loc.gov/rr/print/resource/013_pic.html).
- OR check with libraries in your area to see if they hold Look magazine and use the publication to select images appearing in articles cited in catalog record NOTES.
- OR purchase copies of all of the materials in one or more media associated with the LOOK Job. Library of Congress Duplication Services can make copies of various types:
- Contact sheets can be ordered as quick copies (photocopies).
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- Negatives - If the Medium field lists only negatives and no contact sheets or color materials, only negatives exist. Negatives cannot be quick copied but can be printed in the form of contact sheets or individual prints.
Expect Delays in Service of Nitrate Negatives
Reproductions of all types are available, but Duplication Services anticipates an 8-10 week turnaround in completing orders, as all negatives must be reproduced at their off-site, cold storage facility.
Clue that a LOOK Magazine Photograph Collection image is affected is:
You may wish to consult with Prints and Photographs Division reference staff (202-707-6394) to determine whether scans may already exist for an image (rare, but worth a try).
To purchase copies through Duplication Services, cite the Call Number above and specify the medium you wish to order. If possible, include a copy of the catalog record when placing an order. Price lists, contact information, and order forms for Library of Congress Duplication Services are available on the Duplication Services Web site).
- Call Number: LC-L9-70-5679-G, no. 4-4A [P&P] LOOK - Job 70-5679
Please use the following steps to determine whether you need to fill out a call slip in the Prints and Photographs Reading Room to view the original item(s). In some cases, a surrogate (substitute image) is available, often in the form of a digital image, a copy print, or microfilm.
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be visible on the left.)
Yes, the item is digitized. Please use the digital image in preference to requesting the original. All images can be viewed at a large size when you are in any reading room at the Library of Congress. In some cases, only thumbnail (small) images are available when you are outside the Library of Congress because the item is rights restricted or has not been evaluated for rights restrictions.
As a preservation measure, we generally do not serve an original item when a digital image is available. If you have a compelling reason to see the original, consult with a reference librarian. (Sometimes, the original is simply too fragile to serve. For example, glass and film photographic negatives are particularly subject to damage. They are also easier to see online where they are presented as positive images.)
No, the item is not digitized. Please go to #2.
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No, another surrogate does not exist. Please go to #3.
If you do not see a thumbnail image or a reference to another surrogate, please fill out a call slip in the Prints and Photographs Reading Room. In many cases, the originals can be served in a few minutes. Other materials require appointments for later the same day or in the future. Reference staff can advise you in both how to fill out a call slip and when the item can be served.
To contact Reference staff in the Prints and Photographs Reading Room, please use our Ask A Librarian service or call the reading room between 8:30 and 5:00 at 202-707-6394, and Press 3.


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- Be the first to review this product
Wine & Liquor are 750ml bottles unless otherwise noted.
CSE = Solid Case Quantity.
Turn around time for order fulfillment is 24-48 hours..
Orders of $100 or more can also be delivered or shipped.
Local Delivery is available throughout the metro area for $20-$35.
Orders going outside of the metro area can be shipped via UPS Ground. Charge is dependent on the weight of the box and where the item is being shipped. Restrictions apply. Please note that inclement weather in the state of Minnesota could potentially delay any items being shipped via UPS.


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Portland, OR 97210
(503) 893-5049
|[Photographs: Adam Lindsley, unless otherwise noted]
Helmed by proprietor Kevin Hutchinson, Kindle Kart sports a domed wood-fired oven that quickly blisters the 24-to-36-hour fermented dough, giving the crust of his Neapolitan pies a great outer crunch and a tender, open crumb. No surprise that Hutchinson's set the bar high for himself, given that he's been making pizza for over 15 years. His cart used to live over on North Mississippi, but he hated the oven there so much that he sold it (to Ned Ludd) and built this one:
|[Photograph: Willamette Week/vivianjohnson.com]
OVEN: Wood
RECOMMENDED: Sausage pie


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Playing this video requires the latest flash player from Adobe.
Download link (right click and 'save-as') for playing in VLC or other compatible player.
The Everett (many-worlds) interpretation has made great progress over the past 20-30 years, largely due to the role of decoherence in providing a solution to the preferred basis problem. This makes it a serious candidate for a realist solution to the measurement problem. A remaining objection to the Everett interpretation (and one that is often considered fatal) is that that interpretation cannot make adequate sense of quantum probabilities. Dvaid Deutsch and David Wallace have argued that, by applying decision theory to the case of a rational agent who believes in the many-worlds interpretation, we can prove that such agents _act as if_ the theory predicted objective probabilities in the sense of fundamental indeterminism, or ignorance of initial conditions. I raise the issue of whether or not this, if true, is all that the many-worlds theorist needs from \'probability\'. I first suggest a reason for thinking that the answer might be \'no\': the reason is that knowing how to act on the assumption that a given theory is true is prima facie irrelevant to the question of whether we have any reason to believe the theory in the first place. I then go on to offer a solution to this problem, drawing on resources from Bayesian confirmation theory. My conclusion is that the problem of probability in the Everett interpretation has been solved.


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liushan wrote:Is V6 going to start soon in the near future? i had a look at the forum, and the newest post is about mid year of 2014, and now it's already 2015.
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For information on exhibition and sponsorship opportunities at RailsConf, contact Yvonne Romaine at firstname.lastname@example.com.
Download the RailsConf Sponsor/Exhibitor Prospectus
View a complete list of RailsConf contacts.
Below is the initial list of confirmed sessions. This is a partial list, and new sessions are still being confirmed. We'll also have a more detailed day-by-day schedule posted in the coming weeks.


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Book Direct with the Owner at Omeo Valley Australia with Accommodation Redcliffe Agent Omeo Valley, for all your adventures and things to do.
Address: Great Alpine Road, Dinner Plain VIC 3898
Address: 993 Benambra Road, Hinnomunjie VIC 3898
Address: 179 Day Avenue, Omeo VIC 3898
copyright © 2020 Accommodation Redcliffe. All rights reserved.


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A table knife from the gently tapering Hidcote range. Mirror-polished finish and made from specially hardened stainless steel.Read more
Hidcote cutlery is an elegantly tapering pattern inspired by natural forms. The gentle curves in each piece give a comfortable and tactile grip. Spoons and forks are made using the highest quality 18/10 stainless steel. Knife blades are made from specially hardened stainless steel to provide the finest possible cutting edge.
All Hidcote cutlery is available with a mirror finish, has a lifetime guarantee and is dishwasher safe.
Length: 234mm
To download or reveive a printed copy of our hospitality catalogue, please click belowRequest a brochure


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Cook the Book: Apple Cider Muffins
Baked goods still warm from the oven—is there anything better? Well, sure, they're pretty good but what about those still at their peak moistness days later? There's a unique and exciting anticipation that comes with desserts that get better with age.
These Apple Cider Muffins from Karen DeMasco and Mindy Fox fall into this category. When the lovely apple-packed and cinnamon-scented muffins emerged from my oven, I was struck by their pliant texture. They had a resilience that made every muffin come out of the tin in a bouncy little round.
While these muffins tasted great still warm, they were downright amazing the next day. Pleasantly chewy and moist, the little cakes seem to be a closer relative to sticky toffee pudding than to the dry, crumbly muffins at so many coffee shops. I'm not sure what kind of muffin magic happened in the time between baking and sampling the next morning, but I sure do like it.
Win 'The Craft of Baking'
As always with our Cook the Book feature, we have five (5) copies of The Craft of Baking to give away this week.
- Yield:1 dozen
- Rated:
- Unsalted butter, for the muffin tin (optional)
- 1 cup granulated sugar
- 1 cup packed dark brown sugar
- 3/4 cup grapeseed oil
- 3 large eggs
- 2 1/4 cups unbleached all-purpose flour
- 1 1/2 teaspoons baking soda
- 1 teaspoon kosher salt
- 1 teaspoon ground cinnamon
- 1 cup apple cider
- 3/4 cups sour cream
- 1 1/2 teaspoons vanilla extract
- 2 crisp baking apples, such as Granny Smith or Mutsu, peeled, cored, coarsely grated, and drained, juices reserved and used as part of the cider measurement
- 1 tablespoon Demerara sugar
Preheat the oven to 350°F. Generously butter a standard 12-cup muffin tin or line it with paper liners.
In a medium bowl, whisk together the granulated sugar, brown sugar, and oil. Add the eggs and whisk to combine. In another bowl, sift together the flour, baking soda, salt, and cinnamon. In a third bowl, whisk together the apple cider, sour cream, and vanilla.
Add one third of the flout mixture and one third of the apple cider mixture to the sugar mixture, folding with a spatula just to combine. Add the rest of the flour and cider mixtures in two additions. Fold in the grated apple, and then divide the batter evenly among with prepared muffin cups, filling each cup three quarters of the way. Sprinkle the tops of the muffins with the Demerara sugar.
Bake, rotating the muffin tin halfway through, until the muffins spring back to the touch, 25 to 30 minutes. Transfer the pan to a wire rack and let cool for 10 minutes. Then turn out the muffins from the pan and let them cool completely on the wire rack.
These muffins are best the second day and will keep in an airtight container at room temperature for up to 3 days.
Varying Your Craft: Apple Cider Quick Bread Pour the batter into a buttered 8 1/2 x 4 1/2-inch loaf pan lined with parchment paper and bake, rotating the pan halfway through, until a cake tester inserted in the center of the loaf comes out clean, 45 to 55 minutes. Transfer the pan to a wire rack and let cool for 10 minutes. Then turn out the loaf from the pan and let it cool completely on the wire rack. This bread is best the second day and can be kept, wrapped in plastic wrap, at room temperature for up to 3 days.
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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Duck-billed dinosaur found with rooster-like adornment
- Scientists say it may have been a signal to buddies or potential mates
- Experts say they%27ve never seen this kind of adornment on a dinosaur before
- Researchers credit skills of paleontologists who unearthed the fleshy fossil
The duck-billed dinosaur known as Edmontosaurus regalis was supposed to be a plain Jane of the Cretaceous. No elaborate neck frill for it, nor horns, nor spikes, nor any of the fancy headgear sported by many of its cousins.
Now scientists have discovered that Edmontosaurus regalis actually had a spectacular adornment unique in the dinosaur world. A beautifully preserved new fossil shows Edmontosaurus boasted a party hat of jiggly flesh atop its head. Researchers theorize that like a rooster's coxcomb, the crest was brightly colored and served as a signal to others of its kind. Never before have scientists found such a non-bony crest on a dinosaur.
"We saw something we simply didn't expect to find – a soft-tissue crest on top of its head," said paleontologist Federico Fanti of the University of Bologna, an author of the new study. "This is changing the way we imagine and even understand dinosaurs."
When Fanti found the 73 million-year-old fossil along a river in Alberta, Canada, in 2011, no one judged it anything special. All that could be seen were some vertebrae sticking out of a coffin-sized sandstone block, and the researchers left the block sitting in the field for weeks before trucking it back to the lab.
As tools liberated the fossil from its stone wrapper, the scientists slowly realized that they had a spectacular find on their hands. What emerged from the rock was an extremely rare dinosaur "mummy," a specimen including not just fossilized bone but also soft tissues such as skin. The greatest surprise came as paleontologist Phil Bell of the University of New England in Australia chipped along the fossil's head and found flesh where there shouldn't have been any.
His first thought, Bell says, was that "it must be some kind of mistake. But every way I looked at it, I could only come up with one answer, and that answer was, this animal had a crest."
The curved crest reached 8 inches high and roughly a foot in length, making it look like a too-small bowler hat for an animal that weighed as much as a small bulldozer and stretched more than 30 feet long. Roosters and condors have brightly colored crests, so Edmontosaurus could have, too.
Some dinosaurs with crests made of bone probably used their headgear for sound production. Edmontosaurus apparently didn't. It was a company-loving creature that lived at least part of the year in large herds, and the crest probably served as a signal to its buddies, relatives or potential love interests.
Scientists not associated with the study, published in this week's Current Biology, said it was persuasive in showing that the fossil had a crest, a find credited in part to Bell's deftness with a chisel.
"Cutting diamonds is easy compared to what these guys have done with this fossil," says the University of Manchester's Phillip Manning, who has also worked on a dinosaur mummy. "The fellows who undertook this prep work were absolute artists." Manning agrees with the authors that the crest very well could've been used as a signal to others in the herd. Many dinosaurs had hidden genitals, so maybe the crest was a clue to gender, he says.
Eye-catching features "are used (widely) in the animal kingdom today," Mannig says. "Why should dinosaurs be any different?"
The discovery shows there's always more to learn, even about animals as common and well-studied as Edmontosaurus.
"Edmontosaurus has been known for, oh, 120 years," says Johns Hopkins University School of Medicine's David Weishampel, co-editor of a scholarly compendium of dinosaurs. "And we had not an inkling that at least some of them, if not all of them, had … a small but significant-sized crest. It all holds together."


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A running discussion on the Cincinnati Reds and everything else in the baseball universe.
Saturday, January 22, 2011
2011 Top Prospect List: #16 Neftali Soto, c/inf
Height 6-2, Weight 180, B/T: R/R, DOB: 2/28/1989
2010 Redlegs Baseball Prospect Ranking: #9
Neftali Soto had one of the more interesting years of any Reds prospect, but ultimately it was another somewhat lackluster year from a development point of view. At this point, it is time for the Reds to focus on what Soto does well, rather than what he does poorly. It's clear that Soto isn't going to be an impact defensive player, but he has power that just about rivals anyone in the system and allow him to develop into an impact offensive talent.
Heading into 2011, it would seem wise for the Reds to settle on first base as his long-term position and would be advisable for Soto to start hitting like one.
2010 Season
It was an odd season for Soto, who repeated high-A. Fortunately for him, the Reds changed affiliates from the pitcher's paradise Sarasota to the more hitter friendly Lynchburg.
He flashed the impressive power and hit to the tune of .268/.319/.460/.778 in 522 ABs. He hit 33 doubles, 2 triples, and 21 homers to go along with a 105/32 K/BB ratio. In his second go-around at high-A, Soto boosted his OPS by .136 points. Unfortunately, his line drive rate plummeted from 23% in 2009 down to 12% in 2010.
Oddly enough, Soto was much more productive against righthanders (.827 OPS in 364 ABs) than he was against lefties (.666 OPS in 158 ABs), which is something that should tip back into his favor as his development continues. It's rather rare for hitters to have a reverse platoon split, but players in the lower minors simply don't have much experience against strong lefties. However, it seems likely that the uninspiring performance against southpaws will normalize as he gains more experience. If so, then his overall numbers will also improve.
Overall, it wasn't a bad performance for Soto, as it is 13% easier to hit a double and 9% harder to hit a homer in Lynchburg than the average park. So, Soto certainly earned each and everyone of the 12 homers he hit at home. Of course, power has never been in question for Soto, but the development of his on-base skill still lags dangerously behind.
Since his arrival in the organization, Soto's offensive profile has been that of an early-count type hitter, as both his walk and strikeout rates have been low. Walks and strikeouts both require a hitter to see a significant amount of pitches, so the more pitches a hitter sees the more likely those outcomes become. However, unlike Juan Francisco who piles up the negative late-count outcomes without reaping many of the positive late-count outcomes, Soto manages to avoid both in equal measure.
When he arrived on the scene, I thought Soto had the type of swing that would enable him to hit for both average and power. So, even though the on-base skill was lacking, he still seemed an interesting and potentially productive offensive prospect. However, he has yet to put it together over a long enough stretch to even come close to reaching his ceiling.
Donning the Tools of Ignorance and Defensive Value
In last year's write up, I was skeptical about the rumors circulating that Soto might be tried behind the plate. In 2010, those rumors were proven true. It was a curious decision, but the front office decided to give Soto some work at the catcher position. Given my view of Soto as an offense-first type prospect, it seemed odd to force him to focus on something other than developing his "hit tool."
The obvious rationale was that Reds were trying to drive up his player value by boosting his positional value. However, the real question is whether Soto is the type of player who can handle such a switch.
Catcher is not only the most difficult position on the defensive spectrum, but also the most unique, which raises the question of how the skills required to play the position compare with those required to play the other premier defensive positions. It's clear that the skills that make a player a good shortstop are equally applicable to second base. But, is the skill set of the catcher more comparable to a shortstop? Or, more comparable to skills found at the lower end of the spectrum?
So, can a player like Soto, who is likely best suited for first base, jump from one extreme to another? Or, does catcher require those skills inherent in those positions closest to it on the spectrum?
When I think about players who have successfully transitioned both back behind the plate and away from it, there are three players that come to mind: Brandon Inge, Buster Posey, and Craig Biggio.
Brandon Inge attending Virginia Commonwealth University, where he excelled as both a shortstop and a relief pitcher. The Tigers selected him in the 2nd round of the 1998 draft and immediately shifted him to catcher. While the catching experiment didn't pan out, it wasn't because Inge was a defensive liability. Quite the contrary, Inge was a very strong defensive catcher, but the tools of ignorance simply sapped his offensive production to the point where he wasn't a viable everyday player. The physical demands of the position dragged down his production to the point where the Tigers were forced to move him off the position. When he was moved to the hot corner, his offensive production improved to the point where he was a viable starter.
Next up is Buster Posey. As a freshman at Florida State, Posey was the full-time starter at shortstop and a Louisville Slugger Freshman All-American. As a sophomore, he was moved behind the plate and the rest is pretty much history. After just one season at the position, Posey was a finalist for the Johnny Bench Award, which is awarded to the best catcher in college baseball. And, of course, he just took home the hardware for the Rookie of the Year Award.
Finally, we have Craig Biggio, who arrived on the scene as a catcher. The Astros were so fond of his bat that they quickly shifted him to second base to save the wear and tear on his body and prolong his career. They feared that they would lose the value of his speed on the bases and his production at the plate far too soon.
These players have several things in common. First, they are all good defensive catchers. Second, they are all good defensive players at premier defensive positions. Inge is not only an exceptional defensive third baseman, but has the athleticism to capably handle the defensive positions higher up on the defensive spectrum. Third, they have good athleticism with strong footwork.
In the end, it does seem like the catcher transition is best handled by those who are coming from the premier defensive positions. Unfortunately, that just isn't the scenario with Neftali Soto.
Overall, Soto played 10 games behind the plate and the results were predictably rather rough. His fielding percentage was a mere .971, he allowed 2 passed balls, and caught only 1 out of 16 basestealers. When he wasn't catching, he played primarily first base. He played 91 games at first, 7 at thirdbase, and 10 behind the plate. So, he spent time at both ends of the defensive spectrum in 2010 and ultimately performed much better at first base.
When all is said and done, Soto projects as an offense-first prospect who is best suited to first base. His footwork isn't impressive and his footspeed is poor. His overall game seems a bit lethargic at times. As a result, he is lacking the quickness needed to move laterally to block balls in the dirt and the footwork to explode out of the crouch and into proper throwing position. In total, his athleticism just isn't strong enough to handle the catcher position.
While the catcher experiment was undoubtedly the most interesting aspect of Soto's year, the more important note is that he went from a full-time third baseman in 2009 to a near full-time first baseman in 2010. Ultimately, that's where he belongs.
Swing Mechanics
Soto has a smooth swing that you don't often associate with righthanded hitters. His pre-pitch setup involves a slightly wider than shoulder-width stance and a high back elbow. Soto seems to tinker with his stride (more on that later), but after he strides he fires his hips, which creates significant rotational energy and generates the power in the swing. After he clears his hips, the bat comes around and through the zone. He does a nice job of controlling barrel of the bat and gets good extension in his swing. His slight uppercut creates good loft and carry on the ball.
Below you can see a few photos of Soto at the plate.
Despite the strong hip rotation, Soto maintains good balance throughout the swing. However, Soto seems to experiment with different strides and has yet to lock into a consistent lower body move.
In this first video, courtesy of RedsMinorLeagues, Soto uses a higher stride. He lifts his foot up high off the ground and brings it forward to transfer his weight and trigger the swing. These types of higher strides are typically used by hitters as timing mechanisms. The downside is that pitchers can upset that timing with good offspeed pitches, which work to get the hitter out on the front foot too early. Here, however, Soto uses it to great effect in hitting a long homerun.
In this next video, Soto is using an entirely different stride. I'm somewhat hopeful that he was just exaggerating this new stride to correct a perceived problem, because I fail to see how anyone can actually hit using this type of stride.
Anyway, take a quick look at Soto in this video clip courtesy of OPvideoNotOrioles on YouTube:
As you can see, his pre-pitch stance finds his weight significantly out over the front foot. In fact, it's so extreme that he even has a forward lean to his pre-pitch stance. As the pitcher winds and delivers, Soto shifts his weight back to his right foot and strides forward ever so slightly with his left foot. However, his stride is way too early. As a result, he ends up spread out well before the pitch enters the hitting box. You can actually see him waiting on the pitch from his spread out position.
This early stride creates two problems. First, spreading out too early saps the swing of power, as the hips simply cannot rotate effectively to power the swing. The wider the stance, the more difficult it is to get good hip rotation. And, when you factor in how early he spreads out, it is even more difficult to generate good hip action. Second, spreading out makes Soto very susceptible to offspeed pitches and pitches on the outer half. He simply cannot adjust to those pitches, as he has already committed towards the pitcher.
It's somewhat similar to the old axiom about playing first base. You stretch to meet the throw, not before the throw is made, because once you get spread out you simply cannot adjust to go get throws that arrive in an unexpected location.
The above clip is such an extreme example that I'd love to just write it off as some over-exaggerated coaching technique designed to rein in his high leg kick. However, it seems to me that he is doing something similar in the following clip courtesy of RedsMinorLeagues.
Below, he faces Johnny Cueto in a 2009 spring training game and again seems to be using a stride similar to what he used in the clip above. It's tougher to see because the video is taken from behind homeplate, but he again seems to have a forward lean in his pre-pitch stance and a very small, early stride towards the pitcher. Once again, he seems to be spread out way too soon, which robs him of good hip rotation in the swing.
Perhaps most tellingly in the two video clips in which he uses the early stride are the outcomes, as he grounds out weakly to the rightside in both at bats. He spread out too soon, which robbed the swing of the power generated by the lower half. By committing too soon, he is unable to adjust to pitches on the outer half. In the end, he is left with nothing but a weak arm swing that results in weak ground balls and easy outs for the pitcher.
When he hits with that type of stride, he may still be able to pull pitches with authority, but it's difficult to imagine him being able to effectively hit the ball to the opposite field. Obviously, more advanced competition will make it much more difficult for Soto to be a productive hitter while using only half the field. I'm not sure why or how often he is using such a stride, but I would encourage him to scrap it entirely, as it leaves him in poor hitting position and unable to properly adjust to offspeed pitches.
Final Thoughts
Ultimately, Soto's future will be determined by his hitting. And, as an offense-first prospect, he's got a lot of work to do as he ascends up the ladder. He's unlikely to ever develop a strong on-base skill, so he'll need to show the ability to hit for average and power if he's going to make it to the majors. If he can't demonstrate those abilities, then his career will likely fizzle out. You can't make a living at the bottom of the defensive spectrum without at least two of the three slash line components.
As his career unfolds, he seems to be following the Juan Francisco career path. Namely, he's sliding down the defensive spectrum and lacking the offensive game to justify a starting job at those positions. But, in fairness, Soto's production hasn't been in the same ballpark as Francisco's. The power is nice, but he simply must be more productive. Soto will need to elevate his offense in 2011, but for now he checks in at #16.
11 comments:
I like soto, He is my breakout candidate for this year.ReplyDelete
Kinda has to, its a make or break season
Yeah, I've been a fan of Soto for a while. His on-base skill is well below what I usually like, but I like his swing and power potential.
Unfortunately, it just hasn't come together for him. He shows flashes, but is a bit too inconsistent. At this point, I don't care much about his defense, I just want to see some thunder in his bat.
I thought he could be a high average, high power type hitter, but I've yet to see it. I'm still a believer, but he needs to hit and soon.
Thanks for the comment!
i just have a feeling that his line drive percentage wont stay that low and the struggles against lefties wont lastReplyDelete
I tend to agree. I suspect changing defensive positions contributed to his less than dominating production. I doubt it's all that easy for a young kid to bounce from 1b to 3b to c and back again.
So, I'm hopeful that a full season at 1b will help unlock his potential. Still, he faces a big jump up to double-A, which is usually one of tougher promotions in the minors. I tend to doubt that they send him back to high-A for a third go-around, but maybe they don't see him as being ready for double-A to start the year. It'll be interesting to see, though I suspect double-A is where he'll start.
Regardless, I really want to see more out of his bat, as it's getting tougher to support an offense-first prospect who doesn't provide top notch offensive production.
Anyway, thanks for the comment!
When we look at all the circumstances for the '10 version of Soto we should be in awe of him.ReplyDelete
Hasn't figured out LHP yet as a RHH.
Hit in a tough park for HR's.
Had a LD% of just 12%.
Had his hamate bone removed in the last offseason.
Hit 21 HR's anyway! Ahh, cha-ching.
Yeah, put his season into proper context and it doesn't look half bad. I still like the swing and the power, but want to see a more complete offensive game in 2011. He simply has to hit. If he doesn't, then "proper context" will begin looking more like "excuses."
Now is the time for Neftali.
Thanks for the comment!
- AnonymousFebruary 27, 2011 at 4:10 PM
i think he has an amazing ass.ReplyDelete
thats.. different lolReplyDelete
- AnonymousJuly 28, 2011 at 7:48 PM
Just watched him play a great game at Mudcats. Two homers, solid base hits - several outs on First Base.ReplyDelete
Thanks for the first hand info. He certainly has some nice tools, but needs to continue refining his baseball skills to get the most out of them. If the bat develops, then it'll likely carry him to the majors in some capacity.
Anyway, thanks for the comment!
I love it, even their innocence, because I knew him playing for ponce and plays very well. It will be very successful!. Too bad I did not dare take a picture with him, is my dream today.ReplyDelete


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|2011 Stanford Graduate School of Business , MS , Management, Entrepreneurship, Venture Capital
Alan Chiu is a Partner at XSeed Capital, with over 15 years of product development expertise in enterprise software and data storage. Alan was previously Director of Product Management at Bycast (acquired by NetApp), an object storage software company with a global customer base that included some of the largest digital content repositories in the world. At Bycast, Alan and his team drove the product roadmap, managed OEM relationships with IBM and HP, and developed strategies to enter new vertical markets.
Prior to Bycast, Alan served as an engineering manager at a network security start-up, and helped develop the market-leading digital prepress workflow system at Creo, which was acquired by Kodak for $1B in cash.
Alan holds a BASc in Electrical and Computer Engineering from the University of British Columbia, as well as an MS in Management from the Stanford Graduate School of Business, where he was a Sloan Fellow focused on entrepreneurship, venture capital, and mergers and acquisitions.


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Well, some of the truth about them anyway.
Two for the price of one:
http://freethoughtblogs.com/pharyngula/ ... eationism/
http://christiannews.net/2014/10/20/cat ... asphemous/
Whatever the theological aspects, both are unscientific since they seek to stifle free enquiry in the interests of religious orthodoxy.
PS And yet another 'gem' from AiG's Georgia Purdom on her Facebook page when she was flagging the second link above and 'having a go' and trying to rebut - she was trying to be clever and was failing:
"He [Guy Consolmagno] then goes on to set up a straw man argument that people who believe in biblical creation treat the Bible like a science textbook. No we don't! I agree with him that science textbooks change all the time and so treating the Bible in the same way would be problematic. But when the Bible speaks about science, history, etc. we can trust it because it's the inerrant and infallible Word of God."
All YECs treat Genesis as 'infallible history' and thus, when it describes natural events, 'infallible science'. Real science does not in the least support Genesis. The Sun existed before Earth and the other planets. The fossil record is NOT a record of a year-long worldwide recent catastrophic 'flood'. And so on.
Georgia Purdom treats Genesis like a science textbook. One that can NEVER be altered, regardless of reality and regardless of new discoveries. FACT.


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According to the 2013 Index of Economic Freedom, compiled and released last week by The Wall Street Journal and the Heritage Foundation, Canada ranks sixth out of 177 countries. Bolivia and Ecuador rank, respectively, 156th and 159th. The Fraser Institute, which publishes a similar index, also last year produced a broader index of human freedom, which incorporates civil and other liberties. Out of 123 countries, Canada ranked fifth, Bolivia 64th and Ecuador 73rd. Canada's gross national income in 2011, according to the World Bank, was $45,560 US, more than 10 times that of Ecuador and 20 times that of Bolivia.
It would surely seem — given these statistics — that Canada has far more to teach these South American basket cases than they have to teach Canada. Not, however, according to David Suzuki, Canada's anti-development guru and climate alarmist-in-chief.
Last week, on the CBC's The Nature of Things, in an interview on The Current and in an article in The Globe and Mail, Mr. Suzuki suggested that Ecuador and Bolivia have "new ideas" to teach those of us trapped in the "neo-liberal" paradigm. In fact, these amount to some very old and very bad ideas that betray, at best, a lack of appreciation for, and at worst, outright hatred of, the very factors that make for freedom, prosperity and, yes, a clean and biodiverse environment.
The three big ideas for which Mr. Suzuki was shilling are extortion, go-it-alone autarchy, and putting nature before humanity by giving rivers and rocks "rights."
Two of these Brave New Ideas come from Ecuador. The most radical is that, under the Ecuadorean constitution, "Mother Nature" is protected. This idea is based on primitive anthropomorphism — that nature is a person — plus a misreading of humans' relationship with the natural world. Confusion is caused because we use "value" in two radically different senses: moral and commercial. The assumption of those such as Mr. Suzuki is that commercial values drive out the moral variety, including concern for the environment. This is the reverse of the truth. Nature has no value but that given it by humans, but the richer we are, the higher the value we tend to give it. Capitalist societies are the ones where nature is best protected. Poor, authoritarian societies are ones where the environmental damage is greatest.
In the example that Mr. Suzuki gave in his documentary — a lawsuit in which two American immigrants to Ecuador sued the local government over dumping into a river — the basic issue was one of private property rights, the surest protector of the environment. Ecuador's Mother Nature constitutional clause was brought in on appeal when the basic system of private rights failed.
Those who claim to speak for Mother Nature inevitably want to use her as ventriloquist's dummy for their own warped values. She is also recruited as a puppet to justify eco-extortion, which was Mr. Suzuki's next "new idea." The thuggish Ecuadorean government of Rafael Correa threatened three years ago that if the rest of the world did not cough up $3.6 billion US, it would proceed to drill for oil in the Yasuni reserve, a place of extraordinary biodiversity. The regime's chutzpah-fuelled rationale was that it could gain twice as much from oil development, so it was doing the world a great favour by non-production, which would not release CO2 into the atmosphere, thus making a major contribution to fighting climate change.
In fact, the world has overwhelmingly told Ecuador to stuff it, despite the UN Development Program's enthusiastically agreeing to administer a Yasuni "trust fund." Mr. Suzuki claims the initiative has raised $300 million, but if you go to the trust fund's website, you will find that, after two years, only $50 million US has been committed, and just $6.5 million US has been deposited — a minuscule 0.002% of the ransom demand.
Mr. Suzuki's final big idea is Bolivia's desire to build its own battery industry in a remote location next to its lithium deposits. Inviting in foreign expertise and investment, perhaps via a joint venture, would appear to be a no-brainer, but since Bolivia has bought into the socialist canard that capitalist investors are pillagers, it insists on going it alone. Mr. Suzuki's authority for the wisdom of this notion was a local Bolivian salt shoveller. The project is years behind schedule.
Things become even more bizarre when Mr. Suzuki suggests that Canadians, when compared with these committed Bolivian loco-upgraders, are mere "hewers of wood and drawers of water." He seems unaware that Canada has a vast manufacturing industry, a large part of which is devoted to resource upgrading. The degree of local upgrading of any resource depends on many factors, from market location to logistics to human capital, but it is best determined by private, profit-oriented, decisions. To imagine that all resources should be locally upgraded is a classic example of what British economist David Henderson has called "do-it-yourself economics," a set of false assumptions universally held by those without economic training but ever ready to castigate greed and materialism.
Innovation and wealth generation depend on those factors on which the Freedom Index is based: the rule of law, regulatory efficiency, limited government and open markets. These are the factors which Bolivia and Ecuador are sorely lacking. The more they indulge in klepto-socialism and centrally planned autarchy, and the more they are supported and encouraged by servant-of-Mother-Earth fantasists such as Mr. Suzuki, the poorer they will be.
Peter Foster, a columnist with the Financial Post, is the author of eight books and winner of the National Business Book award and numerous magazine awards.
The editorial pages editor is Gordon Clark, who can be reached at
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June 24, 1964 - October 29, 2013
Mount Hope, NY
Florence Sefcik, a Senior Officer of the Unified Court System in White Plains, died unexpectedly on October 29, 2013 at Orange Regional Medical Center. She was 49.
The daughter of the late William and Florence Weppler Carr, she was born June 24, 1964 in Queens, NY. Florence married Kevin Sefcik on September 22, 1984 and they moved to the Mount Hope area in 1989 from Queens. She was a member of St. Joseph's R.C. Church in Middletown.
She was a loving wife and mother who often put others before herself. She was a devoted sister to all of her siblings. She will be remembered as strong willed and independent. She was organized and wished to have things in order for her loved ones. Florence was a spiritual woman who enjoyed the beach and spending time with her family. A true animal lover, she nurtured many animals and was a lifetime supporter of animal charities.
In addition to her husband, Kevin, Florence is survived by her son, Christopher of Queens; daughters, Kate of Chester and Michele of Middletown; her loving grandson, Wally; three brothers: James of Queens, Charles of New Jersey and William Carr of Long Island; sisters: Susan Carr of Long Island, Jane King of Washingtonville and Anne Virgilio of Bloomingburg; father-in-law, Frank "Pop" Sefcik of Middletown; brother-in-law, John and his wife, Jean; sisters-in-law, Elizabeth Sefcik and Rosemarie McDonough and her husband, Michael; as well as many neices and nephews.
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UNCW Summit to Explore Future of Entrepreneurship in SE North Carolina
Wednesday, February 20, 2013
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Here's a hypothetical for you to consider.
What if the NBA asked teams to use a player's nickname on the back of his jersey instead of his last name? So, what if Glen Davis had "Big Baby" on the back of his jersey instead of "Davis?"
It's not going to happen with the Orlando Magic this season or maybe ever. But league officials reportedly are considering having the Miami Heat and Brooklyn Nets players wear their individual nicknames on their jersey backs in at least one of the four Heat-Nets games this season.
Heat and Nets players reportedly were asked to submit the nicknames they would like on their jerseys.
What do you think of the idea?
Heat guard Ray Allen supports it.
"We're still kids, playing a kids' game," Allen told The Associated Press. "Even though we're now men playing a kids' game, we still remember where we come from. Everybody had a nickname and it's a way to let the fans in a little bit more."
But at least one player, Kendall Marshall of the Phoenix Suns, doesn't like the idea.
Josh Robbins covers the Orlando Magic and the NBA for the Orlando Sentinel. You can reach him via e-mail at email@example.com and connect with him on Facebook at facebook.com/JoshuaBRobbins. Follow him on Twitter at @JoshuaBRobbins.


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Study of A Combination Pill With GS-7977 and GS-5885 for Hepatitis C in People With HIV
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01878799
Recruitment Status : Completed
First Posted : June 17, 2013
Results First Posted : September 15, 2016
Last Update Posted : September 15, 2016
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
- Present treatment for hepatitis C includes the use of a weekly injection and two different pills. This treatment is associated with serious side effects. Drugs that can be taken by mouth and cure HCV infection without serious side effects would be a great help to the large number of people infected with HCV. GS-7977 and GS-5885 are new medications being developed to treat the hepatitis C virus (HCV) infection. They are still being researched and are not approved by the Food and Drug Administration. They are being developed as treatment for hepatitis C as a single pill taken once a day.
- To determine whether a combination of the two study drugs can safely and effectively treat HCV infection in people with HIV infection and who do not have cirrhosis of the liver.
- Individuals who have HIV infection and have liver disease caused by infection with HCV.
- Participants will be screened with a physical exam and medical history. Blood samples will be collected. Urine samples will be collected from participants who might become pregnant. If a participant has not had a liver biopsy in the past 3 years, one will be required.
- Participants will take one pill daily for 12 weeks. This pill will be a combination of the two study drugs.
- Treatment will be monitored with frequent clinic visits and blood tests over a total of 60 weeks.
|Condition or disease
|Hepatitis C HIV
|Drug: GS-7977/GS- 5885 FDC
|Phase 2
Chronic hepatitis C virus (HCV) infection is a major public health problem with an estimated 180 million people infected worldwide. In the US an estimated 4.1 million people are infected with HCV which is the principal cause of death from liver disease and leading indication for liver transplantation. Significant advances have been made with the approval of directly acting antivirals (DAA) namely the protease inhibitors, telaprevir (TVR) and boceprevir (BOC) which have been shown to significantly improve rates of sustained virologic response (SVR). Response rates to these new combinations in HIV/HCV are also very promising, however treatment has been characterized with high rates of toxicities.
Recently several trials have confirmed the efficacy of potent DAA therapy without concomitant IFN in the treatment of HCV monoinfected individuals. Given the improved response rates achieved with a combination of DAAs with fast HCV suppression and improved side-effect profiles; and the need for better therapy for HIV/HCV co-infected subjects, we propose a study to determine the safety, tolerability and efficacy of 12 weeks of treatment with a fixed dose combination of GS-7977 and GS-5885 in HIV/HCV Genotype 1 (GT-1) subjects. We hypothesize that anti-HCV therapy that does not rely on the host immune system will provide an enhanced rate of SVR among HIV/HCV GT-1 coinfected subjects. The findings from this study will aid in our understanding of determinants of response to an IFN-free regimen in HIV/HCV coinfected individuals.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|50 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|An Open Label Trial to Assess Safety, Tolerability, and Efficacy of the Fixed Dose Combination of GS-7977 and GS-5885 in HCV Genotype 1 Subjects Coinfected With HIV
|Study Start Date :
|June 2013
|Actual Primary Completion Date :
|September 2014
|Actual Study Completion Date :
|September 2014
Experimental: HIV
Subjects with HIV and HCV
Drug: GS-7977/GS- 5885 FDC
The GS-7977/GS-5885 FDC product combines a potent HCV nucleotide inhibitor and a potent HCV NS5A inhibitor and will be given for 12 weeks.
- Percentage of Participants With Achieved SVR12 (HCV RNA <LLOQ 12 Weeks After Completion of Treatment) [ Time Frame: 12 weeks after completion of treatment ]The primary end point was sustained virologic response [plasma HCV RNA level <12 IU/mL by real-time HCV assay (Abbott)] at 12 weeks after treatment completion (SVR12) among all patients enrolled in the study.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Eighteen years of age or older at screening.
- HCV treatment-naive, as defined as no prior exposure to any IFN, RBV, or other approved or experimental HCV-specific direct-acting antiviral agent.
Participants must be willing to practice either:
- Abstinence from sexual intercourse or
- At least 2 forms of contraception including one barrier method from 2 weeks prior to Day 0 through 30 days after the last dose is received.
i. Female partners of male study subjects may rely upon hormonal contraception as one of the 2 methods; however female study subjects may not.
Chronic hepatitis C infection defined as one of the following:
- Positive for anti-HCV antibody, HCV RNA, or an HCV genotype at least 6 months before screening, and positive for HCV RNA and anti-HCV antibody at the time of screening or
- Positive for anti-HCV antibody and HCV RNA at the time of screening with a liver biopsy consistent with chronic HCV infection (or a liver biopsy performed before enrollment with evidence of chronic hepatitis C disease, such as the presence of fibrosis).
HIV treatment status:
Documented HIV infection, ARV untreated for > 8 weeks preceding dosing and having either:
- a CD4 T-cell count greater than or equal to 500 cells/mm3 within 8 weeks of Day 0 or
- an HIV viral load less than 500 copies/mL with a stable CD4 count for at least 3 months.
Documented HIV infection on a stable, protocol-approved, ARV regimen for greater than or equal to 8 weeks prior to dosing and is expected to continue the current ARV regimen through the end of study with all of the following:
- a CD4 T-cell count > 100 cells/mm3
a documented plasma HIV-1 RNA level less than the level of detection for at least 8 weeks preceding dosing.
If the lower limit of detection of the local HIV-1 RNA assay is < 50 copies/mL (e.g.,< 20 copies/mL), the Screening plasma HIV-1 RNA level cannot exceed 50 copies/mL.
- HIV ARV agents including only combination regimens consisting of medications from the following list: tenofovir (TDF), emtricitabine (FTC), efavirenz, raltegravir, and rilpivirine administered according to their manufacturer s prescribing information. (reference Section 10.3 for additional information)
- Documentation of hepatitis C genotype 1a, 1b or mixed 1a/1b
Absence of cirrhosis, defined as one of the following:
- A liver biopsy performed within 36 calendar months of screening showing absence of cirrhosis.
- FibroTest score of < 0.48 AND APRI of < 1 performed during the 8 weeks preceding dosing (In the absence of a definitive diagnosis of presence or absence of cirrhosis by the above criteria, a liver biopsy is required).
- Able to effectively communicate with the Investigator and other center personnel.
- Willing to give written informed consent and comply with the study restrictions and requirements.
- If opioid-dependent, subjects must be participating in a supervised treatment.
- Participants must have a primary medical provider outside of OP8 and the NIH for medical management.
Subjects who meet any of the following exclusion criteria are not to be enrolled in this study:
Current or prior history of any of the following:
- Clinically significant illness (other than HCV) or any other major medical disorder that may interfere with subject treatment, assessment or compliance with the protocol; subjects currently under evaluation for a potentially clinically-significant illness (other than HCV) are also excluded.
- Gastrointestinal disorder or post-operative condition that could interfere with the absorption of the study drug.
- Poor venous access interfering with required study blood collection.
- Clinical hepatic decompensation (i.e., ascites, encephalopathy or variceal hemorrhage).
- Solid organ transplantation.
- Significant pulmonary disease, significant cardiac disease or porphyria.
- Unstable psychiatric disease (Subjects with psychiatric illness that is well-controlled on a stable treatment regimen or currently not requiring medication may be included).
- Any malignancy or its treatment that in the opinion of the PI may cause ongoing interference with host immunity; subjects under evaluation for malignancy are not eligible.
- Significant drug allergy (such as anaphylaxis or hepatotoxicity).
- Chronic liver disease of a non-HCV etiology (e.g., hemochromatosis, Wilson s disease, alfa-1 antitrypsin deficiency, cholangitis).
- Patients with renal impairment or uncontrolled medical problems that could place them at high risk for developing renal impairment.
- Positive test at screening for either HBsAg or quantifiable HBV DNA (completed only if necessary to rule out chronic HBV)
- Current use of non-protocol approved ARVs.
- A new AIDS-defining condition diagnosed within 30 days prior to screening or active, serious infection (other than HIV or HCV) requiring parenteral antibiotics, antivirals or antifungals within 30 days prior to Day 0.
- Cirrhosis of the liver
- Screening or baseline ECG with clinically significant ECG findings.
Abnormal hematological and biochemical parameters, including:
- Neutrophil count < 750 cells/mm(3)
- Hemoglobin < 9 g/dL. If Hgb is < 11g/dL in women or < 12 g/dL in men. Other causes of anemia should be excluded as medically indicated.
- Platelet count less than or equal to 50,000 cells/mm(3)
- Estimated GFR (calculated by the CKD-EP(I) equation) < 50 mL/min/per 1.73 m(2) if not on ARV or < 60 mL/min if on ARVs
- ALT or AST greater than or equal to 10 times ULN
- Serum lipase greater than or equal to 1.5 times ULN (at screening or during the screening period)
- Direct bilirubin greater than or equal to 1.50 times ULN
- Albumin less than or equal to 3.0 g/dL
- INR greater than or equal to 1.5 times ULN unless subject has known hemophilia or is stable on an anticoagulant regimen affecting INR.
- Donation or loss of more than 400 mL blood within 8 weeks prior to first dose administration.
- Poorly controlled diabetes mellitus indicated by hemoglobin A1C > 10% at screening for known diabetics.
- Known hypersensitivity to, GS-5885, GS-7977, or formulation excipients.
- Pregnant/Breastfeeding women.
Co-enrollment in other clinical trials is restricted, and requires approval of the Investigator.
Study staff should be notified of co-enrollment status.
Need for use of the following medications from 21 days prior to the start of study drugs through the end of treatment:
- Hematologic stimulating agents (e.g. erythropoiesis-stimulating agents (ESAs); granulocyte colony stimulating factor (GCSF); thrombopoietin (TPO) mimetics)
- Chronic systemic immunosuppressants including, but not limited to, corticosteroids (prednisone equivalent of > 10 mg/day for > 2 weeks), azathioprine, or monoclonal antibodies (e.g., infliximab)
- Investigational agents or devices for any indication
- Medications for disease conditions excluded from the protocol (e.g., active cancer, transplantation) are not listed under this Concomitant Medication section and are disallowed in the study.
- Concomitant use of certain medications or herbal/natural supplements per PI discretion expected to result in pharmacokinetic interactions resulting in increases or decreases in exposure of study drug(s) as listed in Table of this protocol.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01878799
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Shyamasundaran Kottilil, M.D.
|National Institute of Allergy and Infectious Diseases (NIAID)
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|June 17, 2013 Key Record Dates
|Results First Posted:
|September 15, 2016
|Last Update Posted:
|September 15, 2016
|Last Verified:
|July 2016
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Direct Acting Antiviral
Treatment Naive
Interferon Sparing
Ribavirin Sparing
Hepatitis A
Hepatitis C
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Flaviviridae Infections
Antiviral Agents
Anti-Infective Agents


text:
The new "A Team" movie opens this week, and there's one person who won't be putting on his best feather earrings to attend the premiere: Mr. T himself. The original star of the TV show blasted the new flick as a repository of sex, violence and filth. From Jam! Showbiz:
And after seeing a preview of the film, he admits he's shocked with how graphic it is.
Mr. T says, "People die in the film and there's plenty of sex but when we did it, no one got hurt and it was all played for fun and family entertainment. These seem to be elements nobody is interested in anymore.
"It was too graphic for me. I've no doubt it will do big business at the box office but it's nothing like the show we turned out every week."
See now, this is why I never really got into watching the old "A Team" as a kid. Mr. T doesn't like the sex and violence and killing, but that was ALL I wanted from the original show. Instead, they just drove around in a van. And some old dude smoked a cigar. It was not the most intense show on television. So I'm actually encouraged by T's hatred of the new movie. That means cool stuff happens in it. Also, I imagine T is still upset that no one uses 1-800-COLLECT in the movie. Or 10-10-220. Or whatever number it was.
Anyway, Mr. T is a devout Christian, which is probably why he dislikes a lot of this graphic stuff. Also, Mr. T beat cancer, and he's not particularly interested in pop culture that has negative stuff like assault and battery and not positive stuff like MR. T TAKING CANCER OUT THE BACK AND GIVIN' IT A FINE WHOOPIN'.
But hey, to each their own. Just because Mr. T doesn't like the new "A Team" doesn't mean you won't. Or perhaps you'll dislike it for a whole other reason. Maybe it won't be violent ENOUGH. Or maybe you kinda hate Bradley Cooper's smug face. There's really no wrong way to hate a new movie.


text:
'Journey to the South Pacific' comes to Norwalk IMAX
Reaching the remote islands of West Papua, Indonesia, is a logistical nightmare.
And that's not even counting the 65-hour plane ride.
But Fairfield County residents needn't take the grueling journey to experience the tropical dreamscape -- an area replete with palm trees, crystal clear water and myriad species of flora and fauna -- that is West Papua.
Get an up-close look at the region in "Journey to the South Pacific," a new film opening this week on the six-story IMAX screen at the Maritime Aquarium at Norwalk.
"We always say that IMAX films take you to places where you never could go yourself," Chris Loynd, the aquarium's marketing director, said. "In this case, even the filmmakers could barely get to some of the movie's remote natural locations, and I'm not talking about the 65 hours it took just to get to West Papua, the island province of Indonesia where they were based."
Narrated in the soothing voice of Academy Award-winning actress Cate Blanchett ("Blue Jasmine"), the film follows directors Greg MacGillivray and Stephen Judson as they lug 25,000 pounds of camera equipment to the South Pacific region of West Papua, where life flourishes above and below the water.
MacGillivray and Judson set off on the Kalabia, a 100-foot trawler that has been turned into a floating classroom for the purpose of teaching local children about native marine life. One of the students is 13-year-old Jawi Mayor, a first-time voyager who becomes the film's de facto protagonist.
"The film is a celebration of a unique island culture that has developed a special relationship with its ocean environment," Blanchett said in a statement. "The photography is spectacular. It's as if we are swimming alongside manta rays and all the other creatures of the reefs."
The film, which plays through Labor Day, complements the aquarium's summer exhibition, "Lorikeets." Visitors can walk through an outdoor aviary that serves as a temporary roost for more than 50 birds native to the South Pacific.
Said Loynd, "This enchanting new IMAX film and the interactions that are possible with the lorikeets will provide a great double-shot of South Pacific summer family fun."
More InformationMaritime Aquarium at Norwalk, 10 N. Water St. Daily at 2 and 4 p.m. through Labor Day. $9.50, $8.50 for youths 13-17 and seniors 65 and older, $7 for ages 3-12, free for ages 2 and younger. 203-852-0700, www.maritimeaquarium.org.
firstname.lastname@example.com; Twitter: @scottgarg
Maritime Aquarium at Norwalk, 10 N. Water St. Daily 2, 4 p.m. through Labor Day. $9.50-free. 203-852-0700, www.maritimeaquarium.org.


text:
It's really interesting, because looking at very simple things make you think in depth about some issues that you may not really consider in Java proper. For example, this is the definition of a very simple structure:
package fr.moresmau.jp.floj.samples;
public class Simple(String data,int port){
So you can see that the package system is Java's and class definition are very similar. There are no constructor, so. Since null are not allowed (nulls are a huge source of bugs, I'll provide a Maybe object or something like that later),
the structure must have all its data filled in. If you want different operations to be done, you just create static functions that take parameters and create what you need, no need for several constructors. So the list of fields is entered straight after the name of the class.
Simple is a structure with a string and an int. It's easy enough to generate the constructor in Java:
package fr.moresmau.jp.floj.samples;
public class Simple{
public final String data;
public final int port;
public Simple(final String _data, final int _port){
if(_data==null){throw new NullPointerException("_data");}
The fields are immutable of course, so we don't bother with a getXXX() method, we just expose the field.
And you can then add setters that return a new object :
... public Simple setData(final String _data){
if(_data==null){throw new NullPointerException("_data");}
if (_data.equals(data)){return this;}
return new fr.moresmau.jp.floj.samples.Simple(_data,port);
public Simple setPort(final int _port){
if (_port==port){return this;}
return new fr.moresmau.jp.floj.samples.Simple(data,_port);
Note the null handling is not ideal, left for later. Note also we avoid superfluous creations if the data will not change.
So far, so good.
Then I decided to implement equals, so that equals is based on the data and not pointer equality:
public boolean equals(final java.lang.Object o){
if (this==o){return true;}
if (o instanceof fr.moresmau.jp.floj.samples.Simple){
fr.moresmau.jp.floj.samples.Simple co=(fr.moresmau.jp.floj.samples.Simple)o;
if (!this.data.equals(co.data)){return false;}
if (this.port!=co.port){return false;}
return true;
return false;
And with this of course the problem of overloaded equals method raises its head. If I want to allow subclasses to add more fields, my equals method won't work for subclasses.
If I check the exact class name in equals, subclasses that only add/overload methods will not be equals to superclasses.
So what can I do? I haven't decided. I could forbid subclasses to define more data fields (that's I think what you have in Haskell: you inherit functions from your type classes but no data).
I could also make the equals method final and not generate it for subclasses, but equality would then ignore the additional fields.
Another option would be to check the class name in that equals method and generate the proper equals method for all subclasses, but that may cause problems if we then extends the FLOJ class by a Java Class (which will be possible since we generate Java code).
But maybe it should be so, that a class is never equals to its subclasses? Returning equals between two instances that have the same data but different behavior (one instance has an overloaded method) is probably an error in the OO world...
Anyway, creating your own language is fun, I'm learning a lot and maybe I'll even end up with something usable!! I'll keep you posted on my progress.


text:
Jul 4th: Independence Day. Center CLOSED
Jul 7th: Presentation on Mosquitos
Jul 21st: Homestyles
BAD WEATHER: Child Care of Southwest Florida follows the Lee County School Board Bad Weather Closing Schedule. Please tune into your local weather station. If school is called off or closes early the center will follow suit. Please be prepared for alternative care in the event of bad weather closures.
Noah, Biera and Anobi, FGCU students chose Messina for their senior project. The students visited Messina, and then met as a group to put together the project details. Noah, Biera and Anobi weeded the gardens and filled them with planting mix and weed cover. They planted seeds and worked with the school age children planting tomatoes and peppers. The project will be passed onto the next group of FGCU students. Look for ripe tomatoes and peppers and bring them home for dinner! Garden vegetables and flowers are to assist parents with fresh vegetables and pretty flowers for their dining table.
The Lion classroom is planning on having a guest from the library to go along with their reading incentive for the summer. The children have already read over 100 books! We will send more details regarding the date of this visit soon.
This year, from May 22 to August 9, the Lee County Library wants to inspire our community to "Build a Better World."
Find activities and events for you and your children.
Play More, Sit Less!
Join us for our July Parent Workshop in our initiative to bring healthy foods and lifestyles to parents. These 15 minute cycle workshops enable parents to attend, receive valuable information and still get home in time for dinner. We encourage all of our parents to attend to help us help you become a healthy and active family. We will have samples of tasty, healthy snacks, prepared by the School Age children in the Care Club. Parents may enjoy their delicious snack during the 15 minute training on July 21st from 5:30-6:30PM
View our Flyer
The patriotic palette of this sweet and crunchy mix makes it a perfect choice for your Independence Day celebration.
In a large bowl, combine the snack mix, blueberries, cranberries, and sunflower seeds.
Place the white chocolate chips into a medium, microwave-safe bowl. Melt in the microwave on High for 60-90 seconds then stir. Melt for an additional 30-60 seconds, if needed.
Drizzle the melted chocolate over the snack mix, and stir until well coated. Turn the mix out onto a large piece of wax paper, sprinkle with blue and red candies, then allow the white chocolate to stand at room temperature for about 1 hour to harden. To serve, break the mix up into large chunks.
Mosquito Life Cycle, is the next segment brought to our VPK children through our partnership with the University of South Florida, with Felicia Nudo. Children will be participating in activities exploring the life cycle of mosquitos. Children in the Bumblebee, Lion and School Age classrooms will explore mosquito larvae and the importance of mosquito control. The July programming will be held on Friday, July 7th. Parents are invited to attend.
Child Care of Southwest Florida 6831 Palisades Park Ct. Suite 6 Fort Myers, Florida 33912 You received this email because your child is enrolled at one of the Child Care Centers of Southwest Florida. Our 6 locations: The Children's Learning Center at FSW | Joseph H. Messina Child Care Center | P.A. Geraci Development Center | The Community Children's Center | Children's Garden of LaBelle | Harlem Academy Update your email preferences to choose the types of emails you receive. Unsubscribe from all future emails


text:
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Drug information provided by: IBM Micromedex
Your doctor should check your progress at regular visits if you will be taking this medicine regularly for a long time.
Check with your doctor if your diarrhea does not stop after 2 days or if you develop a fever.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.
If you think you or someone else in your home may have taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine may lead to unconsciousness and possibly death. Symptoms of overdose include severe drowsiness; fast heartbeat; shortness of breath or troubled breathing; and unusual warmth, dryness, and flushing of skin.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine.
This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
Portions of this document last updated: June 01, 2020
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