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Focus On: Hedge Trimmers
Trimming overgrown hedges and shrubs is a must this time of year, as your clients are looking for a well-manicured property, which includes more than just their lawns. Selecting the right hedge trimmer for your crews is even more important now with all of the emissions laws and regulations that you must follow. To be sure you are complying with all of the regulations in your area, do your research by starting here with the following hedge trimmer descriptions. If you need more information about the following hedge trimmers, use the circle numbers provided at the end of each product description.
Echo is equipping most of its line of Hedge Clippers with new RazorEdge blades, which are laser cut and precision ground for long-lasting sharpness and enhanced cutting performance. These blades are currently on Echo's HC-150 and HC150i Hedge Clippers. Echo offers a full line of Hedge Clippers featuring single- or double-sided blade configurations as well as two different shaft lengths and an articulating blade set that rotates a full 180 degrees.
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Husqvarna's 326HD75x is a well-balanced, lightweight hedge trimmer that is equipped with Husqvarna's exclusive E-tech II engine. This design offers low emissions, low noise and low weight without sacrificing high power and high torque. Additional features include air-purged design for ease in starting Husqvarna's patented LowVibe system, which reduces vibration from the engine, transmission and cutterbar to help decrease operator fatigue and increase control. With a 29-inch blade length, this double cutting edge trimmer offers a long cutter bar for extended reach.
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John Deere introduces the H20DLE Hedge Trimmer. Lightweight and well balanced, Pro-Series hedge trimmers come equipped with low-emission commercial M-Series engines that deliver super-efficient power without the hassle of electrical cords or battery packs. The offset five-position swivel handle rotates 45 and 90 degrees for more comfort and the 24-inch dual-sided double-reciprocating blade cuts branches up to 1-inch thick.
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Little Wonder Gas Hedge Trimmers come equipped with high-carbon steel blades that maintain a sharp cutting edge even after heavy-duty use. All models feature double-reciprocating blades engineered to glide smooth for flawless, vibration-free trimming and cutting performance in any direction. Shock mounts in the handle assembly enhance user comfort. A power packed commercial-grade 21.2cc engine with electronic ignition and a primer bulb carburetor ensures quick starts and the transmission features hardened steel gears to produce higher torque.
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Maruyama introduces the HT2300DR Hedge Trimmer, which weighs 10.9 pounds and comes equipped with a 22.5cc Maruyama LE commercial engine. The induction-hardened-chrome steel blades are polish-ground sharpened on all three cutting surfaces for a cleaner cut. The five-position rotating handle available on the HT2300DR makes vertical and angled trimming faster and easier.
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The RedMax CHTZ2401 double-sided hedge trimmer is equipped with Komatsu Zenoah's Strato Charged engine plus a new gear case and connecting rod with sealed bearing for longer service. The 23.6cc two-cycle engine complies with CARB II and EPA Phase 2 clean air standards by introducing fresh air into the engine between the exhaust gases and the fresh charge of air/fuel mix. The CHTZ2401's double-sided, 24-inch, dual reciprocating blades are at an ergonomic 1.62-inch pitch. Rotatable handle and chain saw style grips maximize operator safety and productivity.
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Shindaiwa announces the single-sided C4 Technology HT2510 hedge trimmer. Powered by a high-torque 1.1-hp, 24.5cc displacement engine, the HT2510 is designed for the demanding commercial market. The hedge trimmer features chrome-plated, self-adjusting blades and a ball and caged needle bearing construction. The HT2510 is a unique cross between 2-cycle and 4-cycle engines. The lightweight, multi-position characteristics and throttle response of the 2-cycle and now include the low noise, improved fuel economy and reduced exhaust gas emissions of a 4-cycle.
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SOLO Inc. introduces the Hedge Trimmer Model 161. The uniquely designed handle can be rotated to a 45- or 90-degree angle and then locked into position to afford the easiest handling position when trimming hedges horizontally or vertically. The lightweight trimmer also has a 29.0cc displacement 2-cycle gas engine and a 24-inch cutting length in addition to an effective anti-vibration isolation system that assures greater operator comfort and easier operation.
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Stihl introduces a new series of professional hedge trimmers — high performance, 2-cycle machines designed to cut and trim hedges, shrubs and bushes. The HS 81 T hedge trimmer offers cleaner cutting performance for everyday trimming, sculpting and growth control. This tough-cutting hedge trimmer is equipped with a 12.5-ounce fuel tank, which allows extended running times before refueling, increasing worker productivity. Stihl's HS family of hedge trimmers is equipped with a 22.7cc 2-cycle engine created for hedge trimmers and features a muffler design that directs exhaust emissions away from the operator.
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Tanaka introduces the HTD-2530PF Hedge Trimmer, which features the QuickTwist handle system that allows the rear handle to be set at any position within a 180-degree range. The hedge trimmer is powered by Tanaka's 1.3-hp, 24.0cc PureFire low-emission 2-stroke engine. Additional features of the hedge trimmer include 30-inch double-sided, dual reciprocating blades and a one-year warranty. The HTD-2530PF also cuts branches up to 0.75-inch in diameter.
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March 26, 2013
WASHINGTON, D.C. - USCIRF released the following letter in response to the issuance by the United States Government Accountability Office of its report on the International Religious Freedom Act: State Department and Commission are Implementing Responsibilities but Need to Improve Interaction.The full report can be found here.
March 12, 2013
Thomas Melito
Director, International Affairs & Trade
United States Government Accountability Office
441 G Street, NW
Washington, DC 20548
Dear Mr. Melito:
I write today on behalf of the U.S. Commission on International Religious Freedom (USCIRF; the Commission) regarding the report by the Government Accountability Office (GAO) entitled, "International Religious Freedom Act: State Department and Commission Are Implementing Responsibilities but Need to Improve Interaction." We thank the GAO for undertaking this important investigation of U.S. promotion of international religious freedom abroad. USCIRF Commissioners and staff worked diligently over the past year with GAO's team of investigators to provide information and answer questions about our work. We appreciate the dedication and professionalism with which the GAO investigators undertook their efforts to understand the complex challenges facing the U.S. government"s global promotion of religious freedom.
We welcome GAO's finding that USCIRF is implementing its primary responsibilities, as set forth in the International Religious Freedom Act of 1998 (IRFA). USCIRF consistently has worked to fulfill its statutory requirements as an independent and bipartisan commission to conduct an ongoing review of violations of religious freedom around the world, evaluate U.S. policy, and provide recommendations to the President, Secretary of State, and Congress. To that end, USCIRF has proven to be a dependable resource for the U.S. government, providing independent analysis of the worst situations involving severe violations of religious freedom around the world and constructive policy recommendations on how the United States can effectively encourage governments to respect the right to freedom of religion or belief.
We also appreciate GAO's survey of nongovernmental organizations, and are pleased that the NGO community holds a very positive view of USCIRF's reports, further demonstrating the high quality of our work and our role as an independent and reliable resource.
Regarding interactions with the State Department, in recent years USCIRF Commissioners and staff have endeavored to improve the working relationship with the State Department generally and the Ambassador at Large specifically. The Ambassador at Large, as an ex officio Commission member, is welcome to attend all Commission meetings, and USCIRF staff has frequent contact with her office. We welcome the GAO recommendation that the Secretary of State and the USCIRF Chair jointly define how the State Department and USCIRF should interact in our mutual efforts to promote religious freedom. We stand ready for such a consultation.
Regarding the impact of USCIRF's findings and recommendations on bilateral relations, it is important to note that IRFA mandates that USCIRF review the facts and circumstances of religious freedom violations based on international standards, and make recommendations to the U.S. government. USCIRF's mandate is neither to conduct diplomacy nor balance religious freedom against other U.S. national interests, and we make clear in all documents and meetings that the Commission is an independent, bipartisan U.S. federal government advisory body, separate and distinct from the Executive Branch and the State Department. However, at times, our findings draw the ire of offending governments that would prefer their shortcomings remain hidden and may result in bilateral friction. We recognize that USCIRF"s role sometimes poses a challenge for the State Department, but that role has been mandated by law, and - as the report notes - it also has produced opportunities for proactive diplomacy. USCIRF will continue to make every effort to mitigate confusion while continuing to fulfill our statutory mandate.
Pertaining to the GAO's findings on the State Department, USCIRF for 14 years has been monitoring the State Department's implementation of IRFA. GAO reviewed USCIRF reports that highlight areas where IRFA implementation has fallen short or where Congress' intent has not been fulfilled. For instance, USCIRF has highlighted the lack of annual designations by the State Department of "countries of particular concern" in recent years, the need for more vigorous U.S. government efforts to raise religious freedom concerns in bilateral relations, and the low placement of the Ambassador at Large within the State Department hierarchy. Of these and other issues, we note the report highlights how the Ambassador"s organizational status differs from other Ambassadors-at-Large, and that the State Department has provided inconsistent reporting policy and guidance to these Ambassadors.
As USCIRF reports have shown and independent studies verified, violations of the freedom of religion or belief can lead to instability and violence, while respect for religious freedom supports conditions that can lead to peace, prosperity, and stability. At a time when restrictions on religious freedom are increasing and many countries are redefining the state's relation to religion, it is critical that the United States government expand and increase its efforts to protect this fundamental freedom. USCIRF is honored to help the U.S. government in this important endeavor.
Katrina Lantos Swett
To interview a USCIRF Commissioner please contact Samantha Schnitzer at (202) 786-0613 or firstname.lastname@example.com .

subset: commoncrawl


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"A thoroughly involving narrative with a sharp, satiric edge, Ignatius's contemporary take on the tragic confluence of love, power and ambition is a sophisticated look at the media mystique and the movers and shakers in our nation's capitol." — Publishers Weekly
Washington Post columnist David Ignatius is one of the most highly regarded writers in the capital, an influential journalist and acclaimed novelist with a keen eye for the subtleties of power and politics. In The Sun King, Ignatius has written a love story for our time, a spellbinding portrait of the collision of ambition and sexual desire.
Sandy Galvin is a billionaire with a rare talent for taking risks and making people happy. Galvin arrives in a Washington suffering under a cloud of righteous misery and proceeds to turn the place upside down. He buys the city's most powerful newspaper, The Washington Sun and Tribune, and wields it like a sword, but in his path stands his old Harvard flame, Candace Ridgway, a beautiful and icy journalist known to her colleagues as the Mistress of Fact. Their fateful encounter, tangled in the mysteries of their past, is narrated by David Cantor, an acid-tongued reporter and Jerry Springer devotee who is drawn inexorably into the Sun King's orbit and is transformed by this unpredictable man.
In this wise and poignant novel, love is the final frontier for a generation of baby boomers at midlife–still young enough to reach for their dreams but old enough to glimpse the prospect of loss. The Sun King can light up a room, but can he melt the worldly bonds that constrain the Mistress of Fact? In The Sun King, David Ignatius proves with perceptive wit and haunting power that the phrase "Washington love story" isn't an oxymoron.
"A splendid, star-crossed Gatsby update that roasts on the same skewer Washington's power elite and the journalists they so easily seduce… Fitzgerald's boozy gloom brightened with social satire, bittersweet romance, and a comic send-up of all that newspapers hold dear, from a man who's been there." — Kirkus
"The emotional integrity at the heart of this novel is searingly honest and makes for a wise and satisfying work." — Library Journal


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TAIPEI, SEPTEMBER 13 - In an interview with Business Weekly, Taisys Group Chairman Jason Ho discussed the company's accomplishments in pioneering the eSIM ecosystem development, and Taisys' Mobile ID delivering the high-security standard and convenience to securing one's digital identity.
Business Weekly interviews Taisys Group Chairman Jason Ho
Issue No.1610, 2018.09.13
The World's First Operating eSIM Ecosystem
"The Smart SIM overlay, which is just a little thicker than a plastic wrap, is not to be underestimated: SIMoME (thin SIM), which we have spent 4 years on to develop, is the core technology and driving force for the eSIM."
Jason Ho, Chairman of Taisys carefully explains the IC chip is eSIM that is device agnostic, transforming any smartphone to support eSIM over-the-air download of mobile operator services. When traveling, the user can also switch between local telecommunications services freely at any time and as needed without having to extract the original SIM inserted in the phone and thus enjoy the convenience of the one-card multi-number services.
If so, will this pose as a threat to the telecom operators who view locking the user's SIM to their network as their main principle?
"eSIM has become the trend of the future. With the help of 5G popularization, it can provide consumers with more sophisticated and differentiated services, break through the current pricing deadlock of telecom operators, and generate more business models. We deliver eSIM as a service to end users on a form factor that creates flexibility and more value to mobile operators and white label partners", says Ho.
Taisys has built up relationships with MNOs and MVNOs globally to enable data connectivity in over 200 countries. Consumers can purchase the slimduet® thin SIM directly from travel-related channels such as airlines, travel agencies, foreign currency counters at airports or E-commerce platforms, and then download the exclusive APP to shop for international roaming plans in the slimduet Platform.
In response to the limitations for mobile virtual network operators (MVNOs) to provide international roaming, Taisys has cooperated with Japan's largest travel agency, H.I.S., and Malaysian and Middle Eastern MVNOs to fully play the role of the distribution center for transnational and cross-border operators and successfully build the world's first eSIM ecosystem.
One-Card Multi-Function, Mobile Banking at the Palm of Your Hands
The integrated value-added service provided by Taisys smart thin SIM not only provides one-card multi-number services and high quality and affordable global telecommunications services, but also fulfills the financial services of mobile banking through mobile phones. Even 2G mobile phone users in Africa and India can immediately benefit from the advantages as low-end mobile phones can be used to conduct mobile payment and wire transfer.
The SIMoME® Vault independent secure element developed by the company has passed the China Financial Authentication for financial mobile technology service certification of the People's Bank of China this March. The cryptographic algorithm of SIMoME Vault has also been verified by the National Institute of Standards and Technology (NIST), and will soon be FIPS 140-2 Level 3 certified. The smart thin SIM, which can enable users to perform authentication and authorization on their mobile banking app for large amounts of wire transfer and other transactions, is most suitable for online banking. In addition, it can also be used for various application services such as Mobile ID, Fintech, medical and insurance. In August of this year, six Japanese companies (5 banks and 1 telecom operator) jointly launched an experimental project to develop the specifications for the digital certification and signature platform over Taisys SIMoME SIM, which was adopted as a supporting project for Japan Financial Services Agency, "Fintech Demonstration Experiment Center".
Ho says that most of the solutions provided by Taisys involve the integration of the most sensitive telecommunications and financial industry in the country. When working with government agencies, security is the top priority. "Our technology can withstand the strictest certification of countries at the national level; this undoubtedly indicates the high appreciation of the stability and security of our technology."
Mobile ID not only for Privacy Protection, but the Missing Piece to Full eSIM Implementation
With the emergence of new technologies such as Industry 4.0, Financial Technology, and Artificial Intelligence (AI), tomorrow's world will widely embrace the lifestyle of an unmanned economy. However, the new technology is a double-edged sword. While we develop intelligence, we should also take care of personal privacy.
Ho believes that, in order to prevent ill-intentioned third-party companies from obtaining huge amounts of big data and to protect peoples' privacy from running unprotected through the Internet, there are two important links in driving the unmanned economy. One is the popularization of 5G as promoted by the telecom operators, and the other is the establishment of a Mobile ID led by the government.
In recent years, the Japanese government has vigorously promoted the new personal number system called "My Number", bidding farewell to the era of the absence of identity cards, giving each civilian a 12-digit lifetime personal number that can be linked to banking and medical records, social insurance, tax filing system or mobile payment certification service. It is expected that the data will be integrated into mobile phone carriers by 2019 to allow people to perform various identity authentication actions with ease through their mobile phones.
Ho strongly supports this policy of the Japanese government, "Promoting Mobile ID is the ultimate means to truly implement online security of privacy." Taisys will work with the Japanese government with its exclusive Mobile ID technology to store certification on the Taisys smart thin SIM and protect personal information from leaking and at the same time, achieve anonymity that meets EU's GDPR regulatory requirements through the FIPS-certified hardware secure element. It is an infrastructure solution that not only meets security regulations but also controls privacy through technology.
"Furthermore, our technology can fill in the missing piece of the eSIM puzzle which is eKYC that is now unattainable by device manufacturers. The eSIM concept is all about user experience. With Mobile ID inside the thin SIM, user authentication can be done online, eliminating the need for user to physically present identification cards at MNO counters, complying to local government imposed KYC regulations electronically," adds Ho.
With the world's exclusive smart thin SIM technology, Taisys continues to create more convenient, safe and smart solutions. A thin film chip is rewriting the future of our technology-driven lives.
About Business Weekly
Founded in 1987, Business Weekly is the most influential Chinese business magazine, with an average weekly paid circulation of 147,339 audited by the ABC (Audit Bureau of Circulation) during January to June 2009. It is the largest authenticated circulation in Taiwan.
About Taisys
Taisys Technologies is a world leader in providing mobile interconnectivity and vertical integration solutions to various industries. Taisys' solutions enable telecom, financial institutions and government organizations to extend innovative mobile services in a secure and convenient manner.
Established in 2005 and headquartered in Taipei, Taisys has built solutions based on its patented core technology SIMoME® (Thin SIM), which decouples value-added services from the main SIM, and empowers industry players the ability to deploy innovative services on the mobile equipment.
Over 1,300 banking and 20 M(V)NO partners have deployed mobile-based value-added services enabled by Taisys' technology and platform to 10 million end-users worldwide.


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Famous kidnapping survivors Jaycee Dugard and Elizabeth Smart have words of wisdom for the three women found this week in Cleveland years after their disappearance.
Dugard was abducted from a California bus stop in 1991 at age 11 and held captive for 18 years in a backyard, where she gave birth to two children conceived by rape. She made an oblique reference Tuesday to the Cleveland case as she accepted an award in Washington from the National Center for Missing and Exploited Children.
"What an amazing time to be talking about hope, with everything that's happening," she said in her brief remarks. She urged the hundreds of people at the annual awards gala not to give up on missing children. "Just urge yourself to care," she said.
In a statement released earlier through her publicist, Dugard said the women need a chance to heal and reconnect with the world. She said that the human spirit is resilient, and that the case reaffirms that people should never give up hope.
Dugard's mother, Terry Probyn, said in Washington that she understood what the relatives of the Cleveland victims were going through.
"I feel the same relief and the same joy that I felt when Jaycee was returned to me safely after 18 hellish years," she said. "I never doubted for one minute that I would someday be reunited with my daughter."
John Ryan, CEO of the center, praised the vigilance of investigators in Cleveland, saying they followed up on tips and never forgot about the missing women.
"There are other missing children out there that are only a phone call away from getting away from their predators," Ryan said. "I have every hope and confidence that this will lead to future recoveries."
Ryan said the three women would likely be honored by his group in the future. "I think they're going to be at the top of the list," he said.
In comments Tuesday on ABC's "Good Morning America," Smart said she was overjoyed to hear about the happy ending for the Cleveland women, who escaped Monday after being missing a decade.
She said the ordeal highlights the importance of the public staying alert and vigilant. She advised the women to focus on moving forward and let go of the past. Smart says it's also important for others to respect the privacy of those women as they recover from the decade-long ordeal.
Smart was kidnapped from her bedroom in Salt Lake City when she was 14. She was freed nine months later when she was found walking with her captor on a suburban street in March 2003.
Dugard, Smart Comment on Cleveland Case
Dugard accepts award form National Center for Missing and Exploited Children
Famous kidnapping survivors Jaycee Dugard and Elizabeth Smart have words of wisdom for the three women found this week in Cleveland years after their disappearance.


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Springetts Brand Design Consultants-Sprout Baby Food Brand
At Design Interviews
Interview with Springetts Brand Design Consultants : Frank Scott: What is the main principle, idea and inspiration behind your design?. Springetts Brand Design Consultants : A brand idea, which seeks to break new ground in the baby food category by the introduction of a fresh, chilled range of part-prepared baby food, similar to formats available for adult consumption. This would allow mums to make their 'own' baby food easily and quickly. The concept name is intended to convey the integrity of the ingredients and how the right food is key to healthy development. Building on this idea, the creative execution is a playful, literal expression of 'you are what you eat'. The intention to present an image of baby as happy, healthy and flourishing with the help of nature's best ingredients. Our hope would be that the aesthetic will reassure through the promise of natural goodness, but that the image and idea will engage emotionally – making mums smile; creating a powerful on-shelf presence. .Frank Scott: What are your future plans for this award winning design?. Springetts Brand Design Consultants : This is a concept and it would be great to see it being used. .Frank Scott: Is your design being produced or used by another company, or do you plan to sell or lease the production rights or do you intent to produce your work yourself?. Springetts Brand Design Consultants : Currently it is a concept that belongs to Springetts Brand Design Consultants. .Frank Scott: What made you design this particular type of work?. Springetts Brand Design Consultants : A gap in the market .Frank Scott: How did you come up with the name for this design? What does it mean?. Springetts Brand Design Consultants : Sprout - new growth, shoots sprouting up and growing - links in with the development of children. .Frank Scott: Who did you collaborate with for this design? Did you work with people with technical / specialized skills?. Springetts Brand Design Consultants : Project was done by Kelly Bennett and Moyra Casey .
Springetts Brand Design Consultants-Sprout Baby Food Brand Images:
End of the article, click here to go back to previous page, or alternatively go back to Design Articles Magazine homepage.


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Affordable Homes for Families in Poverty Hard to Find in Columbia
COLUMBIA - Local realtors, contractors and housing authority employees say it is becoming more and more difficult for low-income families to find an affordable place to live in Columbia. For some in our community, it's a constant battle to find a roof they can afford to keep over their heads, and actually owning that roof is becoming a far off dream for families in poverty.
That's the case for Angie Skipworth and her 18-year-old daughter Maddi, who live in a two-bedroom condo together.
"It's not perfect, but it's livable and we've had places that weren't as livable." Skipworth said.
They used to live in a rented house, but had to downsize when their combined paychecks couldn't cover the bills. Skipworth is a devoted daycare employee, even though she earns barely more than minimum wage, $9 an hour. Maddie, one of three of Skipworth's daughters, is a recent Hickman High School graduate who plans to start classes at Columbia College in the fall. She works in fast food and chips in so the pair can continue living her.
"I don't even have enough money to pay rent with one paycheck, which is just frustrating," Skipworth said. "It's to the point where its laugh or cry and some days you just cry you just do."
The family feels like it's always battling the bills. Skipworth said it's her daughters who keep her fighting to provide.
"They become your driving force, life hasn't been perfect, life hasn't been easy."
Maddie's having to work isn't the only sacrifice this family makes to survive. The constant struggle with money impacts every decision they face.
"Do you want to eat steak or do you want to have a decent place to live... I have to figure out if this gets paid before this because we have to have electricity or I have to have my medicine this week."
Skipworth said her money troubles will keep her in this condo for now.
"Owning a house would be great, we could do whatever we wanted with it, but with the money I make it's just not a reality."
Even if she wanted to buy a home in Columbia, it would be hard to find one she could afford.
"Prices are increasing and the lower price ranges are just almost disappearing," said Columbia Board of Realtors Director Jessica Kempf.
According to the Columbia Board of Realtors, homes below $100,000 on the market, seen as affordable entry-level homes, are hard to find. Between 2008 and 2012, houses on the market for less than $100,000 dropped by 8 percent, those less than $75,000 decreased by 6 percent and those less than $50,000 decreased by 18 percent. Throw in the challenge of getting a loan and you can throw away any idea of living the American dream.
"A lot of people can't afford that down payment, which is a big part of it right now too," Kempf said.
Toss in new construction to the equation and Columbia is building onto the problem.
"It's not gonna get any easier," Scott Linnemeyer said, owner of Beacon Street Properties.
The houses contractors are adding to the market are far from affordable for those in poverty and there's a lot of them. In 2012, realtors sold 238 newly built homes in Columbia. They come with a bigger price tag too, selling on average for $248,145 in 2012.
"It's tough because of the land costs, once you throw that variable in there it's just hard to get under that 150 mark," Linnemeyer said.
Contractors are shelling out more money to build houses because of new city codes along with increased land and permit costs.
"It's all good stuff, it just costs real money and it eventually gets passed on to the buyer," he said.
The high prices will keep Skipworth from calling herself a buyer anytime soon.
"The money that I make if I own a house and something went wrong with it, when would I be able to fix it," she said.
Instead, she and her daughter will focus on getting through tomorrow together.
"A big part of our life is that we make those decisions together," she said.
This story is part of a new project KOMU 8 News is starting to address a problem that faces our area, yet remains hidden from view for many of us -- poverty. We're calling this effort "Poverty in Plain Sight" because, though many people choose not to see it, its effects cut across all parts of our lives.
In fact, the poverty rate in Columbia is 22.9 percent of the population versus around 14.3 percent for the state of Missouri. To give you an idea of who falls in that category, a family of four making $22,811 or less for an annual income would be considered poor. KOMU 8's mission in the months to come is to shed light on the issues those in poverty face on a daily basis and look for solutions.


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For Information: 800-782-1967
The Beacon Hill Collection of outdoor lighting is inspired by traditional English designs. These lantern-style fixtures have appealing "window panes" topped with a contoured cap and finial. The frame is crafted with Vivex, a material twice the strength of cast resin. It's non-corrosive, UV-resistant and backed with a 3-year limited warranty. This outdoor wall light features a sienna finish and seedy glass. From Maxim Lighting.


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Epic Life Success Summit, learn more!
For more of these articles, rule breakers, energetic solutions or concepts, for more ease and grace in your life or business, connect with me at http://sheevaunmoran.com. Grab my 5 Essential Energies for Success by texting the word "energy" to 949.214.4294 with your name. Remember that energy is within you…let it shine today!


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Weekly religion rail, with items on the day of prayer, a Bible-reading marathon, the seventh day of Passover and more.
All faiths welcome on day of prayer
The National Day of Prayer is a day designated by the United States Congress as a day when all Americans regardless of faith are asked to come together and pray in their own way. It is held on the first Thursday in May, which is May 1 this year.
On April 17, 1952, President Harry S. Truman signed a bill proclaiming the National Day of Prayer into law. It was in 1972 that the National Prayer Committee was formed. It went on to create the National Day of Prayer Task Force, with the intended purpose of coordinating events for the National Day of Prayer. In 1988, President Ronald Reagan signed a bill into law decreeing that the National Day of Prayer should be held on the first Thursday of May.
Those opposed to a national day of prayer have established another observance that coincides with the National Day of Prayer called the National Day of Reason.
Bible-reading marathon to begin Sunday
The 19th annual U.S. Capitol Bible Reading Marathon will begin at 7 p.m. Sunday, April 27. For 90 continuous hours, every word of the Bible will be read aloud and without comment, ending at 2 p.m. on Thursday, May 1, with the reading of the final chapters of Revelation.
During those five days, hundreds will gather on the West Front of the U.S. Capitol to read or listen to a portion of the Bible. The U.S. Capitol Bible Reading Marathon began in 1990. It is part of a weeklong celebration of prayer and the Bible.
The marathon will be Webcast around the world at www.DCBibleMarathon.org
All about the seventh day of Passover
In Israel, Passover is a seven-day holiday, with the first and last days observed as legal holidays and as holy days involving abstention from work, special prayer services, and holiday meals.
The seventh day of Passover, Shvi'i shel Pesach, is a full Jewish holiday, with special prayer services and festive meals that will be held Saturday, April 26.
This holiday commemorates the day the Children of Israel reached the Red Sea and witnessed both the miraculous splitting of the sea, the drowning of all the Egyptian chariots, horses and soldiers that pursued them, and the passage of the red sea.
Hasidic Rebbes traditionally hold a tish, or gathering, on the night of Shvi'i shel Pesach and place a cup or bowl of water on the table before them. They use this opportunity to speak about the splitting of the sea to their disciples, and sing songs of praise to God.
Survey Says
An extensive survey by the Pew Forum on Religion & Public Life details the religious affiliation of the American public and explores the shifts taking place in the U.S. religious landscape.
People not affiliated with any particular religion stand out for their relative youth compared with other religious traditions. Among the unaffiliated, 31 percent are younger than 30 and 71 percent are younger than 50. Comparable numbers for the overall adult population are 20 percent and 59 percent, respectively.
Good Book?
"A Church of Her Own: What Happens When a Woman Takes the Pulpit" by Sarah Sentilles.
Thirty years after the first group of women was ordained by the Episcopal Church, women are among some of the most vital and successful ministers in all Protestant denominations, even as churches struggle to hold on to their members.
Sentilles enters the lives of female ministers — women of various ages and races, in a range of churches — to paint a portrait of what it's like to serve as a woman of faith today. Their stories take readers from their calls to the pulpit through their ordinations and service in congregations. These women show readers how the church can be more welcoming to the women who are its lifeblood.
Get to Know … John Knox
John Knox (1510–1572) was a Scottish clergyman and leader of the Protestant Reformation who is considered the founder of the Presbyterian denomination.
Influenced by early church reformers such as George Wishart, he joined the movement to reform the Scottish church. He was caught up in the ecclesiastical and political events that involved the murder of Cardinal Beaton in 1546 and the intervention of the regent of Scotland, Mary of Guise. He was taken prisoner by French forces the following year and exiled to England on his release in 1549.
While in exile, Knox was licensed to work in the Church of England, where he quickly rose in the ranks to serve the King of England, Edward VI, as a royal chaplain. In this position, he exerted a reforming influence on the text of the Book of Common Prayer. In England he met and married his first wife, Marjorie. When Mary Tudor ascended the throne and re-established Roman Catholicism, Knox was forced to resign his position and leave the country.
Knox first moved to Geneva and then to Frankfurt. In Geneva, he met John Calvin, from whom he gained experience and knowledge of Reformed theology and Presbyterian polity. He created a new order of service, which was eventually adopted by the reformed church in Scotland.
On his return to Scotland, he led the Protestant Reformation in Scotland, in partnership with the Scottish Protestant nobility.
The Word
Omnipotence: The concept that God has infinite power; he is able to do anything that he wishes that is consistent with his own personality. -- Religioustolerance.org
Religion Around the World
Religious makeup of Sweden
Lutheran: 87 percent
Other (includes Roman Catholic, Orthodox, Baptist, Muslim, Jewish, and Buddhist): 13 percent
- CIA Factbook
GateHouse News Service


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During two ceremonies on Friday evening and Saturday morning, UNC Pembroke conferred degrees on 533 graduates.
Winter Commencement saw 61 students graduated with master's degrees on Friday in the Givens Performing Arts Center. On a blustery Saturday morning, 453 students received bachelor's degrees in the Main Gym of the English E. Jones Health and Physical Education Center.
While giving his customary advice to graduates, Chancellor Kyle R. Carter thanked the graduates for inspiring him. "What makes it so great," he said, "is the people here at this university, each with their own unique story."
Commencement speaker and Grand Marshal Dr. Tim Ritter also turned the tables, walking into the throng of graduates and asking them to speak at their own commencement. The offer was met with cheers.
"Oh my gosh!" the first student said. "What I've learned ... in my six years here ... is that you have to do your work."
Another student thanked faculty members, Drs. Len Holmes and Ben Bahr, for his internship in their science labs. And another student said her most meaningful educational experience happened far from Pembroke while studying abroad in Spain.
The graduate students also weighed in: "My memories are about the great faculty here. I know they often wondered why we didn't learn enough in high school. I've become a high school teacher to make sure you don't say that about my students."
"My bachelor's degree at UNCP taught me to teach, and my master's degree taught me to be a leader in my school and my profession," said another student, who earned both degrees in six years.
Dr. Ritter brings an outstanding reputation as a teacher to the lectern. He was the recipient of the 2013 UNC Board of Governors Award for Teaching Excellence. A 17-year veteran physics teacher and director of the Undergraduate Research and Creativity Center, Dr. Ritter is well traveled. As a commander in the Navy Reserves, he was deployed twice after 9/11.
Dr. Ritter said he was challenged to give memorable advice to the graduates. So, he gave them advice from Dr. Seuss, reading from "Oh the Places You'll Go." He earned a standing ovation when he finished.
As one of the nation's most diverse schools, UNCP's students have, as Chancellor Carter noted, incredible stories to tell. Many of them will go far to follow their dreams and many have already traveled far to arrive at this day.
From Hamlet, N.C., Crystal and Ronnie Long graduated together Saturday. One of 21 graduating veterans, Ronnie was deployed twice to the Middle East while earning a degree in criminal justice.
"We met in junior high, and we've done everything together," said Crystal, who graduated with honors and recently started a job teaching second grade. "My wish," Ronnie said, "is to share this Christmas with family."
Business major Luke Rotramel got off work in Greensboro, N.C., at 5:30 a.m. Saturday morning to attend commencement. He is well traveled.
"Last summer, I smuggled Bibles into China - 604 of them," said Rotramel, who also visited Burmese refugee camps in Thailand. "My wish for the future is to balance mission work with my job."
James Ellison hopes his talent for musical theatre will take him all the way to Broadway. He has acquired other skills that will help pave the way.
"I was in my first play in the fourth grade, and I joined the volunteer fire department in the seventh grade," Ellison said. "I will go to the fire academy, and, hopefully, land a some acting roles."
Graduating Magna Cum Laude Saturday, Elka Groothuis traveled far to attend UNCP. A soccer player from the Netherlands, she will remain at UNCP to join the master's program in sports administration.
Some students, like Marajo Kellihan and Jacob Glenn, stayed closer to home. As a school founded in 1887 to train homegrown school teachers, the pair, who earned Master of Arts in Teaching degrees Friday, exemplify UNCP's mission. Kellihan grew up in Bladenboro, N.C., and Glenn in Laurinburg, N.C., and both are teaching science at their former high schools.
1st Lt. Dawu Bowman, who was deployed to Iraq and Afghanistan four times, studied at several universities over seven years to earn a degree in criminal justice from UNCP.
Effie Locklear, who works in the Political Science Department at UNCP, took 10 years to earn a Bachelor of Arts degree in American Indian Studies. At first, she said graduation was not even a goal.
"I just wanted to learn, and after my first class in American Indian Studies with Dr. Linda Oxendine, I was hooked," Locklear said. "It gave me something exciting to look forward to every day."
"With brains in their heads and feet in their shoes," UNCP's diverse graduates paused to celebrate before commencing their next journey.


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Date(s) - Saturday, June 30, 2018
1:00 pm - 4:00 pm
Joshua Creek Heritage Art Centre
The artists of Joshua Creek Studio are pleased to share the magical experience of watercolour printmaking, a medium like no other. Their exploration of colour and texture is inspired by the natural surroundings at Joshua Creek and by each other. An approach of experimentation, discovery and play allow masterpieces to evolve and become treasured works of art.
Our gallery is celebrating it's 10th Anniversary this year, but Sybil has been teaching and exhibiting here, at her family farm, for 37 years!
Come and see the extraordinary art created in this inviting and inspiring place.


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GPS-fix icon in the upper left corner turns off, app changes and I have to wait between 6 and 15sec to get a new fix even if I did not move a centimeter.
Worse is that the position during the switch-over is sometimes kilometers off, as the app uses the location from the network, which depends on the size of the network cell and the location of the next tower. If you are in a location based app, that switchover can even cause additional network traffic as e.g. maps needs to load a new tile or g:geo does the "nearby caches" search in a non-interesting area.
The technical background is the application lifecycle in Android and the recommendations to safe battery just don't mix.
When app one (e.g. maps) is brought to background, the GPS receiver is switched off, then the switchover happens and only after the
onResume() has finished, it is turned on again. Unfortunately the Android system itself seems not to cache the GPS info for a little time and offers that to the next app as a potential current location, but just falls back on network location.
A solution could be for the Android system to cache the GPS location and add an uncertainty linear to the age of the fix. So while the location + uncertainty is smaller than the distance from the location obtained from network, the GPS location would be used. And then after the mentioned 6-15 sec, the real GPS data would take over.


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It all started when I was bored in Dalaran, my finger hovered over the ESC key, preparing to log off. Something that has become remarkably easy since the RealID stupidity.
Just as I pressed the ESC key and the system menu popped up, I noticed someone
LFM Tempest Keep.
I thought to myself
Why not?
Invites out, summons accepted, in we went.
Buff time
We engage in the usual start of raid ritual of buffing. No one is bothering with fish feasts or flasks – it's a level 70 raid and it's filled with 80's.
A quick glance at my raid UI shows there's one other Mage in the raid, so I automatically select them and plant a big fat Focus Magic on them.
My Focus Magic is accompanied with my usual pithy macro:
Focus Magic on you, bring on the crits!
Then I stumble.
Rather than the usual automated "thanks for FM" message, I get
Thanks, you want me to respec Arcane?
You play your game, I'll play mine.
I play Fire, I always have.
I love Fire. It could be as weak as a Warlock and I'd still play Fire.
Krizzly plays Frost, he always has.
He loves Frost. It could be as weak as a Hunter and he'd still play Frost.
Larisa plays Arcane. She loves Fire, but right now loves Arcane more. I think she'd respec Fire with the slightest nudge.
TotalBiscuit plays Arcane because it's the only spec to play. Playing anything else, particularly Frost proves you're an idiot. He plays Arcane because as the best Mage spec, you would be gimping your raid by a good 50 dps if you played anything else.
He isn't sentimental, he doesn't play a spec because he loves it. He only plays it because it is the best!
Which of course makes me wonder why he isn't playing the current best raiding spec… Fire.
Let's face it, if Jong finds Arcane Mages simple and boring… they are simple and boring. He wont be their poster boy.
Do whatever is fun for you!
Apart from the fact that I was a nobody amongst nobodies in a PuG retro raid, thus really had no right to tell anyone what to do, I replied the only way I know.
You do what makes you feel good
🙂 Frost
Gota love a Frostie that loves Frost 😉
I felt a little sorry for the player, living under fear that they should respec from love to practicality.
I chuckled to myself on the 1st boss fight, while the string of
Popped up on the screen.
Ahhh Fire, on a Fire boss.
I was soon laughing hysterically, wondering if I should have done a quick respec to my secondary spec.
Of course exchanging PvE Fire for PvP Fire really wasn't going to fix things.
It was irrelevant anyway, I just popped open my spellbook and cast Frost spells directly from the book (you don't think I'd waste space with Frost spells on my toolbar do you? Next you will be wondering if I even bothered spending the gold buying Arcane spells from the trainer).
Seriously folks, when it comes to WoW, a game, play it the way you want to play it.
Fire, Frost, Arcane, Wand Spec – whatever floats your boat, do it.
You may be the only person in the game to spec that way, but just remember.
Contrary to popular opinion, 10,999,999 people can be wrong!
If it's right for you, then it is right.
Arena Fire
I'm lucky I play with a few folk that don't care and subscribe to my play whatever you want attitude.
Every now and then they ask if I have a particular Frost talent that is an Arena winner. I gently remind them I am Fire and, everything cool, we move on.
I've been seeing more and more people in BGs running with Fire. It's still a bit of a surprise.
Natural for me, unnatural that I am fighting against Fire.
The other night we came up against a dual Fire Mage team. I didn't realize at 1st, but the Dragons Breaths and Blastwaves gave the game away.
I almost felt sorry for burying them both, almost and not for long.
I am happy they are playing fire because let's face it, you wouldn't be playing fire in the Arena unless you loved it.
Gnomer and Out!
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License.


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Back in June I told you about the brilliant concept of Boots Treat Street in my post 'It's Mummy's turn to get a treat.' In a nutshell Boots Treat street is an extension of the much-loved Boots Advantage Card, allowing customers to shop online with their favourite high street brands, while collecting Advantage Card points.
I personally think this is a genius idea for us 'Mummies' and 'Daddies' who are constantly forking out for presents and gifts for other people along with the day to day essentials and never having a penny for themselves. Now, whilst we shop we can earn points on our card and treat ourselves to that much needed perfume (because you are don't to you last squirt) guilt free!
One of the online shops working in collaberation with Boots treat Street is the gorgeous chocolatier Thorntons! My mouth is watering just mentioning the name….I am a true chocoholic. I could eat the stuff for breakfast!
Thornton's are celebrating their 100th year this year and have very kindly offered the most brilliant competition for you to take part in!
It is to win a fantastic Thorntons Chocaholic Hamper (worth £50). Crammed full of chocolate temptations, this hamper is complete with a selection of luxury chocolate, including the popular Continental Viennese Truffles and tasty Moments – the perfect feel-good gift! Yummy!
All you have to do to enter is
- Tell me your idea of chocolate heaven!
Bonus entires include
- Tweeting ' I would like to indulge & #win the Thorntons chocoholic hamper worth £50 on @MultipleMummy's blog http://bit.ly/p3Zrcz '
- Subscribing to my blog via email or RSS
- Liking my facebook page and saying hello!
- Following me on Twitter
Please leave a comment letting know which actions you have done!
So here's me wishing you lots of luck!
This competition is for UK residents only. It will close on September 20th at midday. The winner will be drawn at random and Multiple Mummy's decision is final. The prize cannot be exchanged for anything else or a cash alternative. The winner must notify me with 5 days or another winner will be drawn at random.
This is not a sponsored post and I did not receive any products in which to write it. It was written solely because I thought you lovely lot would like it and deserve it!


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I find myself in the impossibility of talking about Marc Simonetti's artworks anymore. Not because I don't like the art pieces Marc Simonetti creates, but because the constant high standard of his works leaves me speechless. He is always surprising and with each art piece he seems to achieve something more. We've seen before how Marc Simonetti enriched the French editions of various fantasy novels by creating some wonderful cover artworks; I've spotlighted a few of them, such as George R.R. Martin's "A Song of Ice and Fire", Patrick Rothfuss' "The Name of the Wind" or Ken Scholes' "Lamentation" & "Canticle", here on my blog too. Now we can see another excellent one. The French editions of Fiona McIntosh's trilogy, "Valisar", published by Bragelonne, reached the third novel, "King's Wrath", and as we can see, "La Colère" as is the French title, has a stunning cover artwork, signed Marc Simonetti. As I said at the beginning I found myself without words, but I still have a wish: some day to see Marc Simonetti's works on the cover of English editions too.
Friday, April 15, 2011
Cover art - "La Colère" (King's Wrath) by Fiona McIntosh
2 comments:
- Memory said...
French editions always make me wish my French was good enough to handle fiction. That country won the cover art lottery.
- April 16, 2011 at 5:20 AM
- Mihai A. said...
I wish that too. But then again, I would not have space for all these editions :)
- April 18, 2011 at 1:15 PM
Subscribe to: Post Comments (Atom)


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A group of US physicists funded by the US Department of Energy have made a material capable of making light travel backwards, at speeds "that appear faster than the speed of light", at the smallest wavelength ever.
The work, led by Costas Soukoulis at Iowa State University, could pave the way for a "perfect lens", and could even have implications for the basic laws of physics. Soukoulis himself says: "Snell's law on the refraction of light is going to be different; a number of other laws will be different."
No natural material is capable of refracting light negatively, so scientists working in this area have to use so-called metamaterials, which can be engineered to have a negative refractive index. Normal materials have positive refractive indices, meaning that light bends to the right of an incident beam. Metamaterials can have a negative index, bending light backwards, to the left of the incident beam.
(Some background on metamaterials here for those who are interested.)
The ultimate goal is to make one that works at visible wavelengths, which would make it possible to build a perfect, flat lens. This is some way off, and in the meantime researchers must learn to build materials capable of refracting light at shorter and shorter wavelengths. So far, the best researchers have been able to manage is microwave or far-infrared radiation.
Soukoulis' material can negatively refract electromagnetic radiation at 1.5 micrometres, or in the near-infrared part of the spectrum. This makes it potentially useful for telecommunications, he says.
"When we have a metamaterial with a negative index of refraction at 1.5 micrometers that can disperse, or separate a wave into spectral components with different wavelengths, we can tune our lasers to play a lot of games with light.
"We can have a wavepacket hit a slab of negative index material, appear on the right-hand side of the material and begin to flow backward before the original pulse enters the negative index medium."
The pulse flowing backward also releases a forward pulse out the end of the medium. Thus, the pulse entering the front of the material appears to move out the back almost instantly.
"In this way, one can argue that that the wave packet travels with velocities much higher than the velocities of light," said Soukoulis. "This is due to the dispersion of the negative index of refraction; there is nothing wrong with Einstein's theory of relativity."
You can have a look at his simulations, which run on Windows Media Player, here. ®


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The Life Sciences Report: Mike, after nearly two decades as a sell-side analyst, you've seen any number of new therapeutic trends emerge and new opportunities appear for investors. Back when you and I spoke in 19981999, you made a strong case for Immunex Corp. and its antibody fusion protein technology, which would be acquired by Amgen Inc. (AMGN:NASDAQ) for $16 billion ($16B) on the strength of Enbrel (etanercept). That was a great call.
Michael King: Thank you. The antibody revolution is not done in the least. Another burgeoning area is the oligonucleotide space, with companies like Alnylam Pharmaceuticals Inc. (ALNY:NASDAQ), Isis Pharmaceuticals Inc. (ISIS:NASDAQ) and Regulus Therapeutics LLC (RGLS:NASDAQ) active in the arena. Sarepta Therapeutics' (SRPT:NASDAQ) morpholino exon-skipping technology has proven to be active and quite exciting in the treatment of Duchenne muscular dystrophy. I like to say we're in a ribonucleic acid (RNA) world these days, and these oligo companies are, perhaps, what antibody companies were two decades ago.
We also see good immunotherapy science being developed, versus the old style that I refer to as "grind it up and stick it back in the patient." That was a crude approach and one that did not prove fruitful. But we are learning more about the basic science behind the immune responseor lack thereofin oncology. Galena Biopharma Inc.'s (GALE:NASDAQ) NeuVax (nelipepimut-S or E75) is a very exciting approach to preventing the recurrence of breast cancer. It is an example of the good science going on in the immunotherapy space right now.
TLSR: Your coverage contains a wide range of market caps, from $100 million ($100M) all the way up to Celgene Corp. (CELG:NASDAQ), with a large-cap $33B market valuation. There is also a lot in between. Many of your institutional investor clientele can't buy micro caps, but I'm wondering if you find that some billion-dollar-and-above investors are curious about stocks on the very low end. How might they take advantage of these smaller opportunities?
MK: There is some mythology about what investors can or cannot purchase. I've seen some of the big hedge fundsand even some venture capital (VC) fundsgo in after micro caps. The VCs haven't been quite as proficient at this as the hedge funds have been, but basically what these investors do is recapitalize (recap) a business. They'll put in as muchor morecash as the current market cap of a company to make sure that its technology progresses and that it retains the bulk of the commercial rights in the process. Let's face it: If investors can go in and recap sub-$100M companiesand really do it rightthey can make logarithmic returns on their investments. Baker Bros. Advisors LLC has done a fabulous job with biotech; one prominent standout benefitting from that technique is Synageva BioPharma Corp. (GEVA:NASDAQ), which is developing an ultra-orphan disease enzyme replacement therapy for a lysosomal storage disorder. The company now has a market cap of more than $1B.
TLSR: Could we go ahead and talk about some companies?
MK: Sure. Galena Biopharma's NeuVax is a very exciting vaccine-type approach to breast cancer. NeuVax is indicated for patients who are ineligible for treatment with Herceptin (trastuzumab) because they are not HER2-positive (human epidermal growth factor receptor 2, also known as "neu"), meaning they do not show 3-plus or greater levels of HER2 expression. NeuVax is an adjuvant immunotherapy that seems to prolong the disease-free survival interval in HER2-negative patientsthose with low levels of 1-plus or 2-plus HER2 expression, which represent 50% of patients. Galena will complete enrollment in its pivotal randomized phase 3 trial in node-positive early-stage breast cancer with low-to-intermediate HER2 expression by H2/13.
TLSR: Mike, going into a phase 3 trial implies that there is clinical proof of concept already. Is that indeed the case?
MK: Yes. One needn't look too hard to find plenty of evidence in the scientific literature that Galena's drug works. Experts have shown that the drug is active. Some of the data generated at the MD Anderson Cancer Center are quite intriguing. Now it is up to Galena to do the registration trial that will be required for the U.S. Food and Drug Administration (FDA) filing. We have the regulatory hurdle to get over and Galena is doing a very nice job of executing on that.
TLSR: The stock has quadrupled over the past 12 months, and so there has already been a lot of value creation for investors. I asked about proof of concept because the data look incremental to me, and competing products could make NeuVax obsolete. I wonder if the NeuVax data strike you as remarkable?
MK: I don't know of anybody else working on products in the same low-HER2 expression area. Understand that NeuVax is an adjuvant therapy for breast cancer in patients who are in remission following surgery and/or chemo. The drug actually works in patients who have node-positive, as well as node-negative, disease. It happens to work a bit better in lower-risk patients than in higher-risk patients, but it could potentially be used in both. To your point, the idea is to prevent relapse, and these patients are typically women who would otherwise just be watched and not receive any therapy at all.
TLSR: You mentioned Sarepta Therapeutics Inc. with regard to oligonucleotide technology, which you seem excited about. Would you comment on it?
MK: Here at JMP, senior analyst Lisa Bayko and associate analyst Heather Behanna follow Sarepta. The company has done a commendable job getting the morpholino technology to work. It goes right at the heart of the genetic defect, or at least one of the genetic defects, in Duchenne muscular dystrophy (DMD). There are subtypes of DMD with different exon deletions, but for exon 51 disease, Sarepta's eteplirsen (formerly known as AVI-4658) seems to be quite active.
TLSR: Sarepta is up more than sixfold over the past six months, and it now has a market valuation of more than $600M. This product and the company have garnered some significant attention in nonscientific and non-business media. For you, is it a cautionary sign that Sarepta has a lot of retail investor presence?
MK: It can cut both ways. On the one hand, it is in keeping with the [former Fidelity Magellan portfolio manager] Peter Lynch maxim of investing in what you know. From that perspective, there's nothing wrong with reading something in the paper and investing in it, whether in biotech or some other industry.
"I like to say we're in a ribonucleic acid (RNA) world these days."
To your point about valuation, investors need to keep perspective. If Sarepta is successful with eteplirsen, it should be worth a heck of a lot more than it is today. The company had no problem raising $125M in mid-December, and you don't raise that kind of money from retail investors. That tells me a fair amount of sophisticated institutional money was in that financing. Institutions do their due diligence on the science, the clinical and the regulatory. The only thing I would add is that investors have to be clear on what their timelines are. There has been a lot of enthusiasm about the possibility of Sarepta filing for approval in 2013.
TLSR: The eteplirsen data have been pretty dramatic in this small group of patients. Do you feel the company may file in 2013?
JMP Associate Analyst Heather Behanna joins the conversation.
Heather Behanna: We think the data look promising. But we think it is highly unlikely, given the small trial sample size, that the FDA will give eteplirsen accelerated approval. There would be huge upside if it did, but we don't see that as likely. We should know in Q1/13: Sarepta won't disclose the information until it has the minutes in writing and everything is set.
TLSR: Mike, I know you follow Onyx Pharmaceuticals Inc. (ONXX:NASDAQ), which had its product Kyprolis (carfilzomib) approved on July 20, 2012, for multiple myeloma. Could you comment on it?
MK: Onyx has done a great job in getting approval for Kyprolis. It succeeded despite significant doubt among many, not only in the Wall Street community, but also the medical community. A fair number of people thought that the FDA wasn't going to approve any drug on the basis of single-arm studies, and that it would ask for another trial. Actually, FDA said it didn't want lousy single-arm studies. Onyx undertook a very good study in a patient population that represented a significant unmet need. Kudos to it. But investors are grappling with a few issues right now.
TLSR What issues?
MK: First, there are the competitive products. The 800-pound gorilla in this new room is Celgene's pomalidomide, now in phase 3 for myeloma and for myelofibrosis. Another competitive threat representing a bit of an overhang is Millennium Pharmaceuticals' (the U.S. oncology unit of Takeda Pharmaceutical Co. Ltd. [TKPYY:OTCPK]) proteasome inhibitor Velcade (bortezomib), which is administered as a subcutaneous therapy, and perhaps will be an orally administered product in the future. The idea of an oral proteasome inhibitor used to scare doctors, but it turned out not to be the deadly poison that many thought it might be.
Velcade has been on the market since 2003. Oncologists have become familiar with it and now manage the side effects very well, especially with the subcutaneous version. However, I'd point out that there is a large population of myeloma patients who have received intravenous Velcade and are probably intolerant to it now. That's a perfect market for Kyprolis, which, I think, is an all-around better drug.
"If investors can go in and recap sub-$100M companiesand really do it rightthey can make logarithmic returns on their investments."
Kyprolis dosing began with a 15-minute infusion to compete with Velcade, but in a bold move the infusion was stretched out to 30 minutes. With the new protocol oncologists could get significantly higher doses into patients over a longer period, and the product has been well tolerated. Some surveys of Kyprolis users have found that clinicians have become comfortable with using doses that are higher than what the label recommends, as well as combining Kyprolis with other agents to improve its efficacy.
According to some of the data presented for newly diagnosed myeloma patient population at the American Society of Hematology (ASH) annual meeting (held in December 2012), the therapy is getting remarkable results100% response rates in some cases. These are relatively small studies of 7080 patients, but not puny by any stretch of the imagination. The more use the drug gets, the better it is going to look. For that reason, it will start out by picking off the low-hanging fruit, which is the relapse/refractory-to-Velcade population.
TLSR: The patients in this study were being treated with combination therapy of Kyprolis, Revlimid (lenalidomide) and dexamethasone, and the data were absolutely stunning. Being newly diagnosed patients, I'm wondering if that implies that the hematologist/oncologist (heme/onc) would want to begin using Kyprolis as a first-line therapy?
MK: Yes. The thought leaders start there, but as word of mouth gets out, publications and journals come out and results are presented at conferences, you'll see followers come to Kyprolis pretty rapidly.
TLSR: Onyx is still just a $5.3B market-cap company. It has doubled in the past year, and it's up 77% over the past six months. How much more upside is there to this stock?
MK: I've been pretty public with my long-term thesis, where I've said Onyx could approach a $10B+ market cap. Look, Millennium was bought for $8B by Takeda. That was with Velcade, a drug that doesn't have the same product characteristics that Kyprolis has. Plus, you have to add in the kinase inhibitor franchise that Onyx possesses. It has regorafenib, which was approved and is the first breakthrough drug in colon cancer since Genentech's (a unit of Roche Holding AG [RHHBY:OTCQX]) Avastin (bevacizumab). I believe approval for regorafenib in relapsed/refractory gastrointestinal stromal tumor is pretty well assured. That's a pure royalty. Onyx doesn't have to spend a nickel against that revenue stream, and the market should capitalize that generously because it is pure profit. A $10B market valuation seems like a very doable number to me.
TLSR: You also follow Ariad Pharmaceuticals Inc. (ARIA:NASDAQ), which just got accelerated approval for Iclusig (ponatinib) for treatment of resistant or intolerant chronic myelogenous leukemia (CML) and for Philadelphia chromosome-positive acute lymphoblastic leukemia. The approval was given three months before the drug's Prescription Drug User Fee Act (PDUFA) date.
MK: Accelerated approval, I think, was to be expected. I said to investors before the approval that if they looked at the FDA's recent pattern with Johnson & Johnson's (JNJ:NYSE) Zytiga (abiraterone acetate) in December and Medivation Inc.'s (MDVN:NASDAQ) Xtandi (enzalutamide) at the end of August, both in prostate cancer, and with Kyprolis for multiple myeloma in July, the accelerated approval of Iclusig was a no-brainer.
TLSR: The Street was not happy that the FDA tacked a black box warning onto the Iclusig label, and Ariad shares sold off. What happened?
MK: I only wish the drug had been approved before the ASH meeting, which was in early December, and not after. That would have helped a little bit. But, frankly, the black box warning, which warns of potential liver and cardiac toxicity, doesn't matter much because the drug is going to sell by word of mouth. The academics know about this therapy. If you watch blogs and patient discussion groups, you see that people are very excited about Iclusig and couldn't wait for its approval. I think the Street freaked out unnecessarily when the FDA put the black box warning on the drug. I also think that the FDA is smart enough to understand that Iclusig is going to get a lot of use. Let's face itlook how long Gleevec (imatinib mesylate) has been around, and look at the relative lack of activity. I don't want to create the impression that these are bad drugs, but treatments like Sprycel (dasatinib) and Tasigna (nilotinib) are better than Gleevec, and they still leave a lot to be desired. I think Iclusig is going to make the older drugs look relatively tame in comparison.
TLSR: You and I have recently spoken about stocks selling off when a drug is approved, perhaps even on good news. Could this have been a factor in Ariad's sell-off?
MK: Oh yes, inevitably. But the black box warning exacerbated that.
TLSR: The scourge of the heme/onc and leukemic patients in general is development of resistance. A patient might do well in the beginning, but then the drug is rendered ineffective when the tumor cells figure out how to pump out or otherwise neutralize the agent. Iclusig inhibits not only its target BCR-ABL gene, but also its isoform mutants, which confer resistance on the tumor cells. I'm wondering if you believe that is going to be the biggest selling point for the heme/onc?
MK: Yes. No question about it. In fact, the data from the trials suggest that the number one prognostic factor in the treatment of CML concerns the development of resistance.
TLSR: Are there any other companies you wanted to speak about?
MK: Pharmacyclics Inc. (PCYC:NASDAQ) is another name in my oncology wheelhouse. We think the company will be a big winner over time. A seminal discovery and some very impressive translational work has been done with ibrutinib, the Bruton's tyrosine kinase (BTK) inhibitor targeting chronic lymphocyctic leukemia (CLL) and other B-cell malignancies. The drug was a real tour de force at the recent ASH conference. It is clear, at least in my mind, that ibrutinib is the Gleevec of CLL.
We are changing the paradigm for CLL treatment. In fact, between BTK inhibitors and PI3 kinase inhibitors, as in the case of Infinity Pharmaceuticals Inc. (INFI:NASDAQ), oral meds are going to transform the therapy of CLL. I think chemotherapy will continue be used and Rituxan (rituximab; administered via infusion) will continue to be used, but now the new drugs will begin to be used in the relapse/refractory patient population. Researchers are also starting to see similar positive responses in patients with mantle cell lymphoma. The question becomes: What happens with other lymphoma subtypes, such as non-Hodgkin's lymphoma subtypes like diffuse large B-cell lymphoma? We have seen signs of activity in these areas.
TLSR: Pharmacyclics was a $1B market-cap company one year ago and is now a $4.25B company. Do you see it as a big takeout like Millennium? Is it on the screen of some big pharma waiting to acquire for $810B?
MK: I think the company could get there on its own merits. But the only real buyer at the moment would be Johnson & Johnson, which made a $50M milestone payment to Pharmacyclics in October for development of ibrutinib in CLL. So far J&J has paid $150M in milestones, and Pharmacyclics could receive up to $675M more in milestones. The company is in the collaboration because J&J's original offer to acquire Pharmacyclics was not acceptable to the board at the time. But that doesn't mean an acquisition won't happen. If Pharmacyclics comes up with a BTK inhibitor that is useful in immunology, then J&J has every incentive to buy it out because it would have yet another blockbuster opportunity that would go up against JAK (Janus kinase) inhibitors and the like. But for now, Pharmacyclics is probably not going anywhere.
TLSR: Are there any other companies you wanted to mention?
MK: Let me give a shout out to Astex Pharmaceuticals Inc. (ASTX:NSADAQ) in the context of the epigenetic platform. Its marketed epigenetic inhibitor is Dacogen (decitabine), which is very similar to Celgene's Vidaza (azacitidine), both of which are DNA hypomethylating agents used in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
TLSR: Astex now has a $259M market cap. This company has really experienced a lot of difficulties. You would think that if you had this successful drug for MDS and AML, you would have a bigger market cap.
MK: There are a couple of things going on here. One is that Dacogen is a great drug, but it's not a magic bullet for MDS or AML. Second, there is the intellectual property (IP) issue. Two things have been protecting Celgene's Vidaza (azacitidine): its orphan disease status, which has now expired, and the fact that Vidaza is difficult to manufacture, so there's been no generic competitor so far. Of course, any generic competitor that would impact Vidaza would impact Dacogen as well. Also, I don't know that management has done itself a lot of favors by hypothecating the drug to Eisai Co. Ltd. (ESALY:OTCPK) and to J&J. Astex owns more of a residual interest in Dacogen, rather than a real substantial economic interest.
However, I think that is about to change, with recently generated data regarding Astex's phase 2 hypomethylating agent SGI-110, which is being tested in MDS, AML and ovarian cancer. SGI-110 is a prodrug (administered in an inactive form and rendered active in the body) of decitabine (Dacogen), which, by the way, is already a prodrug. The data so far look very good. If Astex can get SGI-110 to market, then a whole different calculus will go on. The company will then have a longer IP life, and with differentiated activity. In addition, it would see the benefits of improved dosing convenience. Also, a biomarker would be developed. A lot of good stuff goes along with SGI-110, and it's not just a reformulated version of decitabine.
TLSR: Many thanks to you.
MK: Thank you, George. I enjoyed it.
Michael King is a managing director and senior biotechnology analyst at JMP Securities. King comes to JMP from Rodman & Renshaw LLC, where he was managing director and senior biotechnology analyst. He has more than 17 years of experience as a leading biotechnology equity research analyst, consistently ranking at the top of Institutional Investor magazine's annual sellside research survey, in addition to being named that publication's "Home Run Hitter" in 2000. King also served as senior vice president of corporate development and communication at ZIOPHARM Oncology (ZIOP:NASDAQ). Prior to joining ZIOPHARM, King was a managing director and senior biotechnology analyst at Wedbush Securities. He holds a bachelor's degree in finance from Baruch College.
[Editor's Note: Michael King joined JMP Securities during the course of producing this interview and has yet to formalize his coverage list.]
Want to read more Life Sciences Report interviews like this? Sign up for our free e-newsletter, and you'll learn when new articles have been published. To see a list of recent interviews with industry analysts and commentators, visit our Streetwise Interviews page.
1) George S. Mack of The Life Sciences Report conducted this interview. He personally and/or his family own shares of the following companies mentioned in this interview: None.
2) The following companies mentioned in the interview are sponsors of The Life Sciences Report: Galena Biopharma Inc. and Johnson & Johnson. Johnson & Johnson is not affiliated with Streetwise Reports. Streetwise Reports does not accept stock in exchange for services. Interviews are edited for clarity.
3) Michael King: I personally and/or my family own shares of the following companies mentioned in this interview: None. I personally and/or my family am paid by the following companies mentioned in this interview: None. I was not paid by Streetwise Reports for participating in this interview.
4) JMP Securities acted as banker for Galena Biopharma Inc.


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Load carrying capacity
SAF and SAW housings are intended for loads acting perpendicularly toward the support surface. If the housing is supported over its entire base and the loads are purely perpendicular, loads are limited only by the bearing.
If loads acting in other directions occur, check that the magnitude of the load is permissible for the housing and the attachment bolts. Guideline values for the safe loads of the housings are provided in the product tables for:
The safe loads have been calculated using a safety factor of 5 against fracture and a factor of 2 against cap bolt yield. For housings made of spheroidal graphite cast iron the values obtained from the product tables should be multiplied by a factor of 1,8.
If the housing is not supported over its entire base, the load carrying capacity for vertical loads may be affected. For additional information, contact the SKF application engineering service.
For a purely axial force, static or dynamic, the permissible load on the pillow block housing should not exceed 65% of P180°. If the incorporated bearing is mounted on a sleeve, check the permissible axial load for the sleeve.
When housings are subjected to cyclic loads or dynamic imbalance, contact the SKF application engineering service.
Additional housing support
When the housing is subjected to loads acting parallel to the support surface, it may be necessary to pin the housing to the support surface or to provide a stop to counter the load.
When loads act at angles between 60° and 120°, or when the axial loads are greater than 25% of P180°, the housing should be pinned to the support surface or a stop should be provided to counter the load. The dowel pins or stop should be sufficiently strong to accommodate the loads acting parallel to the support surface. Dimples indicating the recommended positions for dowel pins are cast into the base of the housing.


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I need to replace door handles on interior doors - have removed old privacy door knob to find a 50mm hole that goes all the way through the door. I wanted to fit standard lever handles in place of the privacy locks but because of the large hole the handle cannot be screwed onto wood of door. Any ideas of where i can buy handles with large diameter rose or does anyone have any idea what to use to fill the hole?
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