text:
SpongeBob SquarePants is making the move from his pineapple under the sea to the Great White Way, in a new musical set to hit Broadway in the 2016-17 season.
"The SpongeBob Musical" will follow the popular Nickelodeon character and his band of friends in a new journey set to originals songs from some of music's biggest names, including David Bowie, John Legend, Lady Antebellum, and Aerosmith's Steven Tyler and Joe Perry.
Plain White T's, They Might Be Giants, Panic! At the Disco, Cyndi Lauper, Dirty Projectors, Jonathan Coulton and The Flaming Lips will also write new songs to fill out the score. Music supervision will come from Tony winner Tom Kitt ("Next to Normal"), with a book coming from Kyle Jarrow ("Whisper House").
U.S. & World
The project co-conceived and directed by Tina Landau ("Superior Donuts"), who says she was attracted to the ensemble nature of the material.
"[SpongeBob's] the classic underdog hero," she explained. "Our production sets him on a hero's journey with real stakes, all the while retaining the show's trippy humor and irreverence."
Landau also said that their actors won't be using prosthetics or costumes to bring the show's characters to life.
"The SpongeBob Musical" will have its world premiere in Chicago's Oriental Theatre beginning June 7, 2016, in a limited engagement through July 3. Casting is expected to be announced shortly.


text:
(The Root) — It's ridiculous that we still have to explain this. That with a black woman in the White House, another starring in the TV show everyone's talking about and another who created said show — plus scores more breaking barriers in politics, business and sports — we still have to explain why certain images simply aren't OK.
Kerry Washington, the star of ABC's prime-time political drama Scandal, told Oprah Winfrey recently that her character, Olivia Pope (a fictional version of real-life "fixer" Judy Smith), represented a "new moment":
For a long time, the only images you saw of black women in media were very stereotypical images, and then we went to this place where all the images of African-American women had to be flawless, perfect — you know, Clair Huxtable — so we could erase that legacy of negativity.
I get what Washington is saying. We've come a long way, and one would think that we should be looking forward instead of back. But unfortunately, there are some who still need a history lesson — namely one Caroline Wozniacki, the former No. 1 women's tennis player in the world.
At a recent exhibition match against Maria Sharapova, Wozniacki decided that it would be fun to stuff her tank top and tennis skirt with towels in order to imitate Olympic gold medalist Serena Williams. When she waddled lopsided to the court and served her first ball as "Serena," the crowd didn't gasp or boo or hiss — it laughed.
And she's done this before, complete with sound effects like Serena's trademark primal scream. Actually, a few tennis players have. Apparently this is what's hot on the court in 2012.
In November at a charity exhibition match in Slovakia, Novak Djokovic padded his shirt with towels before his first serve in front of a small crowd sipping champagne. The announcer even got in on the joke: "Serena Williams to serve." Afterward Djokovic, who is ranked No. 1 in the world, explained, "We wanted to play quality tennis, to entertain crowd, came up with some good shots, good impersonations. I hope you liked it." Later that same month in Toronto, Andy Roddick stuffed his shorts and then threatened to "stick this ball down" the throat of an official, all in imitation of U.S. Open champion Serena Williams. In every case the crowd roared with laughter.
This seems like an actual thing in tennis. I'll have to admit that I don't watch (unless Serena is playing), but making fun of the sport's stars is apparently an end-of-the-season ritual. At that same match in Toronto, Roddick also impersonated John McEnroe, Sharapova and Djokovic with jerky arm moves, hair fixing and insistent ball bouncing. But when it came to the black woman, her mannerisms and physical quirks weren't enough, because they never are. Instead the big booty and her temper get center stage.
All this reminded me of a quote I've often repeated from Williams herself. During her one-on-one interview for the first volume of HBO's documentary The Black List, Williams summed up the challenges of her career:
Every article that I do read, it's like, you know, "She overpowered her opponent." Meanwhile I'm thinking, "They don't know how hard I can really hit," because I'm telling you, I'm not even hitting the ball as hard as I can. It's a lot more than just hitting the ball as hard as you can. It's all about strategy and moving your opponent and just really figuring them out. Like, I never get credit for [the] mental, and it's kind of frustrating.
Yes, it's frustrating. Frustrating that even in jest, caricatures are caricatures. The big-chested, big-bottomed black woman is an easy punch line that still hurts. It's still not OK. Despite her grand slam titles, her gold medals and Wimbledon wins, the sum of Serena Williams can still be reduced to her parts. And people will laugh without a clue (or care) that the joke isn't just tired — it's offensive, it's dangerous and it needs to stop.
"It's an image that we have seen before," explained Whoopi Goldberg on The View Tuesday during a discussion about Wozniacki's impression.
Not only have we, as black women, seen it, but we've tried to sink it. The meme that our bodies are our only means of distinction gets swatted down every day by women who recognize the figurative and literal catcalls. Williams herself is one of them. If only the women like Wozniacki could get that. But we can't hold our breaths — or the accomplishments.
"You can make as much fun as you want to," Goldberg said. "She's still gonna beat your ass."
Helena Andrews is a contributing editor at The Root and author of Bitch Is the New Black, a memoir in essays. Follow her on Twitter.
Helena Andrews is a contributing editor at The Root and author of Bitch Is the New Black, a memoir in essays. Follow her on Twitter.

subset: commoncrawl


text:
About This File
- All 32 NFL Teams!
- 2017-2018 NFL Schedule!
- Chargers and Rams Now Play in LA!
- Rams New Uniforms!
- Launch Edition Rosters 2/4/18
- Some playbooks / depth chart re-adjusted for 3 WR sets.
- Team AI & stats based upon success in the 2017-2018 season.
- 2018 AFC & NFC Pro Bowl Rosters.
- Halftime Stats!
- Scrambling QB's (Russel Wilson, Marcus Mariota, Jameis Winson, and more!)
- Press Start instead of B to throw a lobb pass.
- (NEW) Hybrid Defenses. (Extra defensive backs!)
- (NEW) 2018+ Rosters 4/6/18
SET Commands Applied :
*Add stats after quarters (Halftime Only)
*More NFL like QB rating value
*PA/PC hack - PC is INT and PA is target
*Player-controlled QB rollouts for playaction passes
*Press Start instead of B to throw a lob pass
*Bruddog's Moving Grapple / Push-Pull Hack
*Directional Punts ~ hold UP or DOWN to angle your punt
*Decrease Fumbles
*Decrease Injuries in SKP Mode
*Decrease Injuries in MAN Mode
*Faster handoffs, pitches, snaps & player control
*Passing game probability table hack
*Ball carrier can break up drone grapples
*PR speed change from SS to actual PR player
*Buck's TSB COM Juice Setter - juice to start at week 8 juice and climb to max
*QB throws ball instead of taking sack and runs less
*COM dive tackling like SNES TSB I
*COM defensive coverage late in season (28 and 32 team codes)
*Jstout 'Logic' Modifier
SET COMMANDS GUIDE by SBlueman :
Recommended Emulator :
FCEUX : http://www.fceux.com/web/home.html
Recommended Setup :
1. Config \ Video \ Check 'allow more than 8 sprites per scanline.'
2. Config \ Timing \ Check Overclocking (old PPU only) and enter '240' into both scan line boxes.
*If you aren't using an emulator that supports these functions, don't care about flickering sprites,
and just want to play, download the NES Classic Edition
Many thanks to other user submitted roms for player stats and editing.
Rosters may not be 100% perfect and any comments are appreciated.
- Special thanks to Maverick209 for his insight on player ratings.
**Please note this is a WIP rom, so check back often for revisions!**
Check out this thread for custom covers for all 32 teams!*
What's New in Version 11.5 See changelog
- Team and player SIM Ratings updated and adjusted
- More accurate depth charts 9/15/17
- Players Added :
Dolphins - S, reshad JONES
Patriots - LB, kyle VAN.NOY
Jets - LB, josh MARTIN
Browns - QB, kevin HOGAN
Ravens - CB, jimmy SMITH
Colts - T, leraven CLARK, NT, al WOODS, LB, a. MORRISON,
LB, jon BOSTIC, CB, rashaan MELVIN, S, darius BUTLER, QB, j. BRISSETT
Texans - LB, dylan COLE, T, kendall LAMM
Broncos - LB, shaquil BARRETT, DE, adam GOTSIS
Chargers - QB, kellen CLEMENS
Redskins - S, deshazor EVERETT
Giants - CB, eli APPLE
Eagles - DE, vinny CURRY, CB, p. ROBINSON
Vikings - RCB, trae WAYNES, LB, ben GEDEON
Saints - S, marcus WILLIAMS, LB, alex ANZALONE
Falcons - LB, duke RILEY
Panthers - QB, derek ANDERSON
49ers - G, brandon FUSCO
Rams - RB, justin DAVIS
Seahawks - T, rees ODHIAMBO
Cardinals - G, evan BOEHM
*IR Players removed who return later in the season and will be re-added.
- SET Commands Added :
*(NEW) Directional Punts ~ press UP or DOWN while punting to angle your punt. (Standard Version / Juiced Version / Juiced Plus Version)
- Dynamic Color Changes
Players will now stand out more on the field
- Players Added :
Texans - RB, tyler ERVIN (c. FIEDOROWICZ IR)
Eagles - K, jake ELLIOTT (c. STURGIS IR)
Bears - LB, n. KWIATKOWSKI (j. FREEMAN IR)
Lions - P, jeff LOCKE (s. MARTIN NFI, k. REDFERN IR)
Cardinals - RB, chris JOHNSON (d. JOHNSON IR)
*Opening day Versions also updated with new SET Command.
- Added 'Opening Day' version with original 11.0 roster upon request.
- Players Added :
Jaguars - WR, keelan COLE (a. ROBINSON IR)
Bears - WR, josh BELLAMY (k. WHITE IR)
- Uniform usage and color changes
- Player rating, depth chart, and SIM ratings adjusted
- Players Added :
Colts - WR, chester ROGERS
Jaguars - WR, arrelious BENN
Chiefs - RB, c.j. SPILLER
Raiders - K, g. TAVECCHIO
(11.2 Ravens Broncos)
(11.2 Redskins Titans)
- Some uniform usage and color changes
- Some player and depth chart adjustments
- Players Added :
Dolphins - KR/WR, jakeem GRANT
Jets - KR/WR, jeremy KERLEY
Chiefs - S, daniel SORENSEN (Eric Berry IR)
- Schedule :
*Week 1 Buccaneers @ Dolphins moved to Week 11 ~ (Prayers to our friends and family in Florida. Stay Safe!)
*Weekly Schedule Dates changed to reflect Thursday Night Football Schedule & will no longer be random
- Player rating, SIM attribute, jersey number, and depth chart adjustments
(BC\Ball Control overpass on all offensive players) Less fumbles from some star players
- SET Commands Added :
*(NEW) Prevent schedule from being random (Standard Version / Juiced Version / Juiced Plus Version)
*(NEW) QB throws ball instead of taking sack and runs less (Juiced Version / Juiced Plus Version)
- AFC NFC Pro Bowl Depth chart and Uniform Colors changed.
- Players Added :
Patriots - T, marcus CANNON
Jets - C, wesley JOHNSON, T, brandon SHELL
Bengals - G, trey HOPKINS
Colts - G, j. VUJINOVICH, T, denzelle GOOD
Chiefs - LB, dee FORD, CB, t. MITCHELL, WR, jehu CHESSON, G, bryan WITZMANN
Raiders - TE, lee SMITH
Packers - P, justin VOGEL
Panthers - WR, damiere BYRD
Seahawks - LB, terrence GARVIN
- *NEW* Added Tecmo Super Bowl NFL MVPS ~ A collection of the greatest all-time players from each team
(thanks to Baron von Lector for allowing us to use his Gold Rom as reference. Input is most welcome!)
- *NEW* Added NES Classic Edition for 10.7.7 and NFL MVPS with basic hacks and sprite limit hack removed.
*Check out this thread for custom covers for all 32 teams!*
- With version 11.5:
- Download


text:
PD.com: the cesspool of the internet and one big retard magnet.
is an idiom that means a particular request or line of conversation is already foreclosed or otherwise resolved, and any attempt to continue it is futile; or that to continue in any endeavour (physical, mental, etc.) is a waste of time as the outcome is already decided.
In that particular thread, probable cause and rights violations should have trumped everything, and that would have made a pretty good discussion. The problem was that the conversation revolved around drugs. Now, I partook in it myself, but if you bring drugs into the whole thing it's going to collapse into a whole legalization thing. The problem with it is is that it's always going to resolve to that. Truth be told I am kinda surprised that RWHN would approve of use of "Advanced search techniques" in a high school even considering his anti-drug stance. But again, we're talking about drugs. It's always going to come back to is weed (not drugs, just weed) really that bad and should it be legalized. BEcause for some reason drugs mean weed. I mean, as far as I can tell no one's going to say that crystal meth should be sold in every convenience store.I could go on and ramble and tangent, but then that would just make another drug thread.
Thining of proper response. But i think regardless rwhn wont be able to convice us. Likewise we wont be able to convince him. And even if we could i cant fault him for not letting us know. It would be like working for a democratic mayor and publically admitting youre a republican.
Quote from: Twiddlegeddon on June 09, 2012, 11:32:09 pmThining of proper response. But i think regardless rwhn wont be able to convice us. Likewise we wont be able to convince him. And even if we could i cant fault him for not letting us know. It would be like working for a democratic mayor and publically admitting youre a republican.Uh, trust me, I can safely say you guys have not convinced me that I am wrong. I do know, that past threads have had past members, slightly alter their viewpoint, usually having a better understanding of the impact of drugs on youth. But I am nobody's shill and speak for me and what I know and believe.
So give me CONTEXT, give me REVIEW and give me BACKGROUNDor SHUT UP
I think it is quite possible to change each other's minds on PD. It's happened before. We just happen to have very strongly-opinioned people, so it's going to be a bit tougher than it might be elsewhere. Doesn't mean we should give up the discussions.
Although I do get sick of the name-calling and shit-flinging ... Can't we quit the "You do not agree with me so you are lesser" vibe? It's cool where it's in good humor, but when it gets in the way of communication...


text:
The new 113th Congress begins today with the election of Republican John Boehner of Ohio as Speaker and Nancy Pelosi, D-San Francisco, as minority leader. (Boehner is in no apparent danger of being ousted, despite Eric Cantor's lusting after the job, Boehner's humiliation on the fiscal cliff negotiation, not to mention the disastrous refusal and quick backtrack on Sandy relief that drew the wrath of New Jersey Gov. Chris Christie. See earlier posts.)
One of the first acts of the Republican leadership is to continue their $1.7 million defense of the 1996 Defense of Marriage Act, despite the defeat of one of its champions, former Rep. Dan Lungren, R-Sacramento.
DOMA is under Supreme Court review, and as we know, the Obama administration abandoned its DOMA defense nearly a year ago, after which it was taken up by House Republicans.
Amid signs of Republican softening on immigration and even gay rights in the wake of election losses, Republicans buried the DOMA provision in their rules package, making no mention of it publicly. That left the field wide open to Democrats to hammer away.
Pelosi spokesman Drew Hammill said the GOP "fiscal responsibility mantra does not extend to their efforts to stand firmly on the wrong side of the future. Republicans will take the extraordinary measure of including an authorization of their efforts to defend DOMA in the Rules of the House of Representatives and by doing so, continue to spend taxpayer funds, already adding up to $1.7 million, in their attempts to defend this shameful law in federal courts and the Supreme Court."
Rep. Mike Honda, D-San Jose, lambasted Republicans for not allowing an up-or-down majority vote on a stand-alone DOMA defense, instead of hiding it in the rules package.
"On this defining issue of our time, House Republicans are continuing to fight for discrimination and using the Rules package to make it seem as if all Members of the House feel that way," Honda said in a statement.


text:
I don't know how familiar you guys are with the Madness of Deathwing encounter from a tanking perspective, but here's the main problem; in phase 2, these adds called Elementium Terrors spawn that apply a rapidly stacking debuff that ticks for high damage called Tetanus, and it is not removable. These adds are supposed to be burned down, but a lot of the time I do this fight, people just DPS the boss and let me die from Tetanus. Anyway, here's my comic idea; it features a nameless tank (or one of the ones from the really old comics, your choice). Just put him in a well-known warrior tanking set and give him a shield, whatever is easiest to draw (as long as it's not Donald).
Panel one:
Shows Krom and as many raid members you feel appropriate.
Krom is healing, and says, "Phase 2, pick up the terrors and burn the boss."
Panel two:
Tank is tanking an elementium terror, raid DPSing the boss.
Panel three:
Mouse over the Tetanus debuff, there are 2 stacks. The tooltip reads, "Inflicts 120,000 physical damage and an additional 40,000 damage every second."
Panel four:
Shows the tank tanking an elementium terror (possibly looking exhausted, damaged -- whatever that looks like). He says, "Guys, can we DPS these guys before I die to Tetanus?"
Panel five:
Mouse over of the tetanus debuff, it has 3048 stacks. The tooltip reads, "OH SHIT" or "YOU'RE FUCKED", whichever you prefer.
Panel six:
Tank is dead on the ground, saying "Guys?" Still no help.
Panel seven:
Deathwing is dead. Krom is next to the chest, looting it. Gigz is rezing the tank, while the tank asks, "Did it drop anything for me?"
Panel eight:
Krom is still looting. The tank is rez'ed.
Krom: "Looks like there's this envelope addressed to you..."
Tank: "Oh boy!"
Panel nine:
The tank opens the envelope; inside is a map of Stormwind with a red X marked somewhere.
Tank: "Looks like it's a treasure map; I better follow it."
Final panel
Shows the tank with a large, empty sack in one hand a treasure map in the other. He is next to Max Blackhammer, who is ecstatic, counting an unwieldy amount of gold on the table. The tank has the saddest possible face you can draw, possibly with puppy dog eyes.
It's a bit long, but I think the build-up is terrific and the end reflects a very common feeling among tanks and will resonate with them. The last panel to the comic is beautiful in my head. I think it's a pretty good idea, and requires fairly minimal drawing for its size, mostly because many of the panels are quite similar. Tell me what you think, and if you decide to draw it, make whatever adjustments are necessary to make it work.
Thanks for listening to my idea!


text:
$$ Tuition is due on Monday of each week $$
Parents please remember to check your family file folder in the front hallway daily and make sure you have all the required paperwork completed!
If you have not had your fingerprint registered please stop by the office. Thank you!
Our center closes at 6 pm. It is $1.00/minute/child if you are late past the 6 pm closing. Thank you for your cooperation.
Beginning September 1st available for VPK families ONLY is a FREE 4 month subscription to ABC Mouse. ABCmouse.com is subscription-based, and children can learn and explore with their parents, or on their own (depending on age and ability), in a safe and secure online educational environment. Parents please take advantage of this subscription and help your child learn and grow.
Monday, September 4th Our center will be CLOSED for Labor Day.
Thursday, September 14th We will have Southern SnoBalls. Don't forget your $2.00!
September 16th National Play-Doh Day celebrates a great childhood play toy. Invented in the mid 1950s, it has entertained millions of children, and allowed them to express their creativity, both at home and in the classroom.
Teddy Bear Clinic from MedExpress– Presentation on hand washing and germs. Details coming soon!
September is national Library Card Sign up month!
Library Card Sign-up Month is held in September all across the country to remind parents and caregivers that a library card is the most important school supply of all.
Library cards are free and provide residents with an almost unlimited number of books, movies, music, information sources and professional librarians who are there to help individuals find exactly what they need.
Register at: http://www.leegov.com/library/card
VPK Parents: please remember to take time and work with your child on their take home activities! A good education begins at home!
1. Childcare providers are babysitters: Childcare is a profession and a very invaluable career. There is not just a quick course that someone takes to become qualified. Many childcare providers have dedicated their lives to this profession and have poured their heart and soul into their classes or programs. They are dedicated to raising up the next generation and are required to take continuing education units yearly.
2. The price of tuition is going directly into someone's pocketbook: The truth is that tuition covers so many costs: supplies, food, furniture, curriculum, replacement, licensing fees, insurance, marketing costs, learning activities, dishes, paper products, safety supplies, office supplies, and more.
3. You get what you pay for: You have to look past dollar signs and look into the heart of a program! Some of the best teachers work in the most affordable programs, and that's a great thing!
4. Men shouldn't be working with young children: Some of the most noteworthy ECE figures who I love reading advice from are men: Tim from Taught by Finland, Teacher Tom, and Scott from Brick by Brick. And honestly, I think my husband rocks! He does a great job with fathering our own children, and all of my classes looked forward to the times he would pop in and say hello.
I hope that the next time you hear one of these myths, you will kindly explain that it simply is not true.
By Katie-Creator of the Preschool Inspirations Blog
Starting September 12th—September 30th our center will be having a Fundraiser to raise money for classroom materials.
Make sure to check your family folders for Midland Catalogs. We appreciate your help in raising money for our center.
"Everything we do improves the lives of children."
At our center we strive to provide high quality early learning experiences. We received 5 Stars again! which is the highest rating in the voluntary Quality Rating Improvement System (QRIS) used by the Early Learning Coalition of SWFL to improve and communicate the level of quality in early childhood programs.
Thank you again for the opportunity to work with your child(ren).
Check out the September Calendar. There is an activity you can do at home with your child every day of the month!
Be Sure to check out our Facebook page!
Child Care of Southwest Florida 6831 Palisades Park Ct. Suite 6 Fort Myers, Florida 33912 You received this email because your child is enrolled at one of the Child Care Centers of Southwest Florida. Our 6 locations: The Children's Learning Center at FSW | Joseph H. Messina Child Care Center | P.A. Geraci Development Center | The Community Children's Center | Children's Garden of LaBelle | Harlem Academy Update your email preferences to choose the types of emails you receive. Unsubscribe from all future emails


text:
Home Antivirus
- Easy to use
- Fast
- Light on computer resources
- Install and forget
- Buy now
F-PROT Antivirus Home edition is fast and easy to use, has a light footprint, automatic update system and offers realtime file system protection.
We offer flexible setup, a light footprint, and automatic Internet or LAN updates, Linux, BSD, and Solaris support, and other solutions for businesses.
Licensing the award-winning CYREN Antivirus engine with integrated F-Prot technology can increase the competitive edge of your technology solution. Check out our OEM and SDK partner program for more information about licensing our technology
We offer full-featured and free 30 day trial downloads for most of our products: home, corporate, servers, and workstations. Download and try before you buy.


text:
Serious Heat: Moroccan Chermoula, an Underrated Hot Sauce-Marinade-Paste Recipe
Note: On Wednesdays, Andrea Lynn, senior editor of Chile Pepper magazine, drops by with Serious Heat.
Do you need to rev up a meal with flavor but are short on time? During a trip to Morocco this summer, I discovered an under-acknowledged ingredient blend: chermoula (also spelled charmoula). I have trouble classifying it as a hot sauce, paste, or marinade. And that's because this combination of chiles, onions, garlic, cumin and olive oil works fabulously as all of the above.
It's my current go-to when anything needs a pick-me-up. I've marinated tilapia in it for 30 minutes, then broiled it. Success. I've stirred it into the rice. Double success. You can rub it under the skin of chicken thighs before sautéeing; mix it into sour cream and slather baked potatoes. The options are endless. Be warned, the recipe below, which I concocted based on Moroccan versions, is quite hot with a massive rush of garlic. But once you taste it, you'll be coming up with reasons to use it.
Note: Remove the seeds from the serrano chiles if you want to tame the fire of this sauce.
Yield: 1 cup Zest Factor: Hot
- 1 small yellow onion, peeled and chopped, or 3 whole scallions, chopped
- 4 cloves garlic, chopped
- 2 serrano chiles, diced
- 1 teaspoon paprika
- 1 teaspoon cumin
- Salt and black pepper
- 1/2 teaspoon lemon juice
- 2 tablespoons water
- 1/4 to 1/2 cup canola oil
- 1. In a food processor or blender, add onion or scallions, garlic, chiles, paprika, cumin, salt, pepper, lemon juice and water.
- 2. Purée ingredients, adding enough canola oil while blending to make mixture emulsify.
- 3. Taste, and adjust salt, pepper and lemon juice, if needed.
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


text:
- Prayer and Worship
- Beliefs and Teachings
- Issues and Action
- Media
- Bible
- Catholic Giving
- About USCCB
I. History and Current Opportunities
A. History and Contemporary Developments
B. Current Challenges and Opportunities
II. Campus Ministry and the Relationship Between Church and Higher Education
A. History
B. The Contribution of Higher Education
C. The Contribution of the Church
D. Campus Ministry Described and Defined
III. Persons Who Serve on Campus
A. The Baptized
B. Professional Campus Ministers
IV. Aspects of Campus Ministry
A. Forming the Faith Community
B. Appropriating the Faith
C. Forming Christian Conscience
D. Educating for Peace and Justice
E. Facilitating Personal Development
F. Developing Leaders for the Future
Empowered by the Spirit: Campus Ministry Faces the Future
A Pastoral Letter on Campus Ministry Issued by the National Conference of Catholic Bishops.
Issued by NCCB/USCC, November 15, 1985. Copyright © 1985, United States Conference of Catholic Bishops, Inc. All rights reserved.
By accepting this message, you will be leaving the website of the
United States Conference of Catholic Bishops. This link is provided
solely for the user's convenience. By providing this link, the United
States Conference of Catholic Bishops assumes no responsibility for,
nor does it necessarily endorse, the website, its content, or
sponsoring organizations.


text:
In our second interview, we will sit down with CZW Heavyweight Champion, Drake Younger! This interview will be filmed on location and released at the end of the month.
Fill out the form on our website and instantly be entered in for a chance to win a free copy of the Best of Drake Younger DVD!
Our first interview with Chikara's Ultramantis Black is now available on our website.


text:
SM-9000B Quiet Computer Mouse
The Nexus SM-9000 quiet pc mouse is an advanced 2.4G wireless quiet laser 1600DPI mouse which connects to your PC or laptop with a super small nano receiver.
You will be amazed how relaxing this mouse is without the clicks. We are currently so used to using the PC, and have come acquainted with track pads, multi-touch displays etc. We no longer need the confirmation of a clicking action. You know when you have clicked or double clicked. You see a graphical reaction of your clicking on the screen. PCs are so fast these days that you practically never have to wait for your PC to respond. So you simply do not need a clicking-sound confirmation of your action. Why still hear the clicking sound? Well it turns out that this is part of switching-technology and it is not so easy to remove the physical sound when clicking. Nexus has managed to find a solution. Using patented switching technology Nexus finally created a soundless/noiseless quiet mouse.
What to expect from the Nexus Quiet Laser Mouse
Note: The "clicking" buttons on this quiet mouse are very quiet, when compared to a standard mouse. If you are applying excessive pressure to any moving part of any device, it will make a sound from the impact of your finger pounding on the moving button. This mouse, however, does not add the normal clicking sound from the button that mice users are accustomed to. The wheel on the Nexus mouse does not have specialized quiet technology applied to it, but is fairly quiet, as most mouse wheels are. This Nexus Quiet Laser Mouse is very nice, truly silent, and is the foremost example of a quiet mouse. This is not just a "quieter" than average mouse, it is a quiet mouse with silent technology applied to it.
Nexus has a lot of customers working in TV and music studios that rely on Nexus components for a truly quiet working environment. Nexus asked some of them to test their silent mouse... and they were delighted. No more clicking-sounds. Just a quiet environment without distracting clicking noises and sounds.
Great For TV, Music, and other Quiet Studios
SM-9000B Quiet PC Mouse
SM-9000B Shape and Material
Nexus has a lot of customers working in TV and music studios that rely on Nexus components for a truly quiet working environment. Nexus asked some of them to test their silent mouse... and they were delighted. No more clicking-sounds. Just a quiet environment without distracting clicking noises and sounds.
The Nexus Quiet Mouse is a comfortable size and is an excellent mouse for desktop use. Yet, the Nexus Quiet Mouse is suitable for laptop users as well. This is because of the small nano receiver which you plug into a USB port and leave there. The Nexus Quiet Mouse nano receiver is so small that you do not need to take it out. Just forget it's there. Furthermore, the Nexus Quiet Mouse is made from quality surface treatments, so it feels good in your hand.
Patented Silent Switch Technology
The switches Nexus used for the Silent Mouse have a patented construction and lack the "click" sound when you press them. You will be amazed how much more relaxing it is when you get rid of this useless sound in your working environment.
Quiet Laser Mouse for Precise PC Work
Nexus has chosen a highly developed laser technology for more precise mouse movements for the SM-9000. The laser precision technology is 1600 Dpi.
Quiet Mouse Technology
Check out this video and you will hear what we mean by quiet mouse technology. The test is not done in a anechoic chamber, so the dB(A) values are just for comparison.


text:
Yesterday wasn't what I expected. I'm a huge history buff, I used to do curatorial work in a Lincoln collection, and I teach at a college named for him. It should have been a big deal for me.
Strangely, though, it wasn't. I woke up, taught a class, read, and went out for some seafood and a movie. It was, in truth, one of the least Lincoln-saturated days of my life. Feeling a little guilty that I didn't celebrate with gusto, I decided to see how some of the more prominent history bloggers spent their bicentennial.
Samuel P. Wheeler was probably the busiest, heading to the Empire State for a whirlwind speaking tour. Kevin Levin indulged in snacks, games, and vintage Lincoln films. "Bah! Humbug!" muttered Dimitri Rotov at Civil War Bookshelf as he snuffed out the light on Bicentennial Eve. Successive visits by the Ghosts of Centennial Past, Bicentennial Present, and Sesquicentennial Yet to Come left him unmoved.
I think the main reason I didn't make an effort to party hard was plain and simple burnout. The history community has been up to its armpits in Lincoln for quite a while now, getting ready for the big day that technically kicked off a whole year ago. It was like seeing a shopping mall decked out with Christmas decorations in the middle of October. By the time December 25 finally rolls around, you're a little numb to it.
So yesterday I felt like a kid who's finished opening his gifts on Christmas morning—all that anticipation, and then after a few frenzied seconds it's over, and you remember that it's back to school in a few days.
Still, as long as it meant more than the presents and decorations, it was well worth celebrating.
(Image from the Library of Congress, Rare Book and Special Collections Division, Alfred Whital Stern Collection of Lincolniana)


text:
iOS is a fantastic platform, but as it approaches its sixth birthday, it's in desperate need of a lick of paint. If you jailbreak your devices, then you don't need to sit and wait for Apple to administer that, because you can take the design refresh into your own hands by theming.
The only issue with that is finding a theme that's as beautiful as the hardware it's running on. There aren't many out there that fit this description, but iMIUI from Xiaomi is one of them.


text:
JOBS1st visits Bernard M. Gordon Learning Factory
JOBS1st visits Bernard M. Gordon Learning Factory
UNIVERSITY PARK, Pa. -- Representatives from Gov. Tom Corbett's JOBS1st initiative were on hand last Thursday (April 10) to tour the Bernard M. Gordon Learning Factory.
The group included Mary Bethea, marketing manager for the Pennsylvania Department of Community & Economic Development (DCED) and Debbie Bowman, executive director of marketing for the DCED.
Several student teams presented their projects for Pennsylvania-based companies VorTic Watches, Solutionwerks, TMP Manufacturing Co. and Penergy Solutions.
Bethea said, "Together with industry, small companies and other clients, the Learning Factory brings the real world into the classroom through projects for engineering students. Many of these projects enable a stronger synergy between the Learning Factory's research and development and the transfer of technology as it relates to economic and work force development."
She added that partnerships between Penn State and businesses put technology on the fast track to commercialization and the marketplace.
DCED works with regional economic development organizations to implement an end-to-end strategy for transitioning technology from the Learning Factory into commercial products that are designed, engineered, produced, marketed and sold by companies based in the state. Bethea explained, "This partnership enables regional economic growth by utilizing a business-friendly environment to attract new companies."
Mary Frecker, director of the Learning Factory, said, "The Learning Factory is happy to partner with DCED to spread the word about the amazing work our students are doing to help advance Pennsylvania-based companies."
Launched by Corbett in 2012, JOBS1st PA supports the continued resurgence of Pennsylvania's manufacturing, life sciences and technology sectors and focuses on renewing and strengthening job training opportunities for Pennsylvanians.


text:
(CNN) - The National Rifle Association has "stooped to a new low" in making robocalls to residents in Newtown, the two U.S. senators from Connecticut argued in a letter to the NRA on Monday.
"We call on you to immediately stop calling the families and friends of the victims in Newtown," the senators wrote.
Follow @politicalticker
Reports emerged last week of Newtown residents receiving robocalls urging them to stand against state legislative attempts to pass stricter gun laws, including a more expansive assault weapons ban and 10-round limit for magazines.
Asked for a recording of the call, the NRA declined to provide the audio but released a statement defending the calls.
"The National Rifle Association has members, contributors, and supporters in Connecticut who expect us to do our jobs and keep them abreast of developments on the legislative front in their state," Andrew Arulanandam, the NRA's director of public affairs, said in a statement about the calls. "We provide the same service for our members and supporters all around the country."
The robocalls come a little more than three months after a gunman massacred 20 children and six adults at an elementary school in Newtown, in addition to shooting his mother, before killing himself.
The mass shooting has since sparked a major debate over gun control that has pitted the powerful NRA against lawmakers and gun-control advocates who want to legislate tougher firearm laws.
Sens. Richard Blumenthal and Chris Murphy addressed the letter to NRA executive vice president Wayne LaPierre on Monday, urging the group to remove Newtown from its call list.
"In a community that's still very much in crisis, to be making these calls opens a wound that these families are still trying hard to heal," the senators wrote.
- CNN's Ashley Killough, Steve Brusk and Eric Marrapodi contributed to this report.
Well when you have so many Senators bent over the desk I guess they do whatever they want. Does NRA own stock in Vaseline, if not they should buy some. The 2014 elections are next year.
I just love it when I read Repukes crap on here when they talk about rights, but they want to take away women's rights on abortion. Hypocrite alert!!!!
NRA – a blood soaked, terrorist enabling anti-American bunch of loud mouths.
What else would exspect from low life gop slime lobbyist like the nra ,any congressman or woman that takes donations from these losers will go down in 2014 ,the lose of death for the gop is the nra ,gop is all done in the mid terms, count on it it should have been their kids !!!!
THe NRA has been on the wrong side of many gun related issues over the course of the years. Why would the support the average person to have armor piercing bullets when the police opposed it.
Who supported gay marriage first, Dick Cheney or Barack Obama?
Wow, the NRA calling the Newton community after the Sandy Hook massacre. The NRA leadership is absolutely disgusting.
I am strong belive that nra are not terroist but parent must keep learn resposity with kids child from away drugs plots bullying game.that people loved only sport hunting and fishing


text:
When you purchase an Ariat product, we offer online warranty registration. Click here to register your product.
Ariat guarantees all of its products to be free of defects in materials and workmanship. We firmly stand behind everything we produce. This, however, is not a guarantee against normal wear and tear. Nor does it apply to product that has been damaged by misuse, accident, modification or unauthorized repair. If you believe you have purchased a defective Ariat product, please follow the specific guidelines below, depending upon where the product was purchased.
Warranty on Ariat products purchased from Ariat.com
If you purchased product from Ariat.com, and you have a warranty issue, contact Ariat Customer Service. Provide your order confirmation number, and the reason for your warranty claim.
Phone: 877-702-7428
E-mail: email@example.com
Warranty on Ariat products purchased from U.S.A retailers (stores or online)
If you have a warranty issue with a product purchased through one of our retailers, contact the Ariat retailer where the product was purchased. Make sure to have your original receipt with you. Upon inspection from your Ariat authorized retailer, consumers may be offered a credit, replacement or repair depending on the defect.
Phone: 877-702-7428
E-mail: firstname.lastname@example.com
Warranty claims on products purchased outside the United States
Contact the Ariat customer service team in that country of purchase. Go to International for the appropriate contact.
Customer Service Hours
Ariat has regular customer service hours.
Hours: Monday- Friday 7am-5pm (Pacific Standard Time)
Phone: 877-702-7428
Email: firstname.lastname@example.com


text:
Looking into the next decade of America's economic evolution
SCHAUMBURG, Ill.–(BUSINESS WIRE)–Zurich in North America today released a new report highlighting what are anticipated to be the next decade's Hottest Growth Industries, in collaboration with Philip Auerswald, an Associate Professor at George Mason University, adviser to the Clinton Global Initiative, and the founding president of the National Center for Entrepreneurship and Innovation.
This report, "Growth Opportunities for the American Worker: Hottest Growth Industries by Decade: 1890-2020," seeks insight into the next decade of America's economic evolution by revisiting 10 prior decades of industrial change and helps provide some perspective around how past trends can help predict future job creation and business growth. The findings suggest that history is slightly repeating itself as manufacturing, energy and agriculture industries are projected to once again become hot categories. In addition, changes in technology will transform services and the ways in which people keep themselves healthy.
Zurich sponsored the report after celebrating 100 years in the United States. After becoming one of the first continental European casualty insurers in the United States, Zurich had a simple goal: to help a growing country, grow even more. Today, the United States is four times more populous and more than 30 times more prosperous than it was a century ago and this report is a reflection of how the company continues to look ahead to identify emerging areas of growth.
Click to download the full report "Growth Opportunities for the American Worker: Hottest Growth Industries by Decade 1890-2020."
About the Author
Philip Auerswald is an Associate Professor at George Mason University, an adviser to the Clinton Global Initiative, and the founding president of the National Center for Entrepreneurship and Innovation. He is the author of The Coming Prosperity: How Entrepreneurs Are Transforming the Global Economy (Oxford University Press, 2012) as well numerous other books, reports, and research papers. He is also the co-founder and co-editor of Innovations, a quarterly journal from MIT Press about entrepreneurial solutions to global challenges.
About Zurich
Zurich Insurance Group (Zurich) is a leading multi-line insurance provider with a global network of subsidiaries and offices in Europe, North America, Latin America, Asia-Pacific and the Middle East as well as other markets. It offers a wide range of general insurance and life insurance products and services for individuals, small businesses, mid-sized and large companies as well as multinational corporations. Zurich employs about 60,000 people serving customers in more than 170 countries. The Group, formerly known as Zurich Financial Services Group, is headquartered in Zurich, Switzerland, where it was founded in 1872. The holding company, Zurich Insurance Group Ltd (ZURN), is listed on the SIX Swiss Exchange and has a level I American Depositary Receipt program which is traded over-the-counter on OTCQX. Further information about Zurich is available at www.zurich.com.
In North America, Zurich is a leading commercial property-casualty insurance provider serving the global corporate, large corporate, middle market, specialties and programs sectors. Life insurance offered in the United States is issued by Zurich American Life Insurance Company, an Illinois domestic life insurance company. For more information about the products and services it offers and people Zurich employs around the world, go to http://www.zurichna.com/zna/aboutzurich/zna-home.htm. Zurich celebrated its 100 year anniversary of insuring America and the success of its customers, shareholders and employees in 2012. Further information about Zurich's 100 year anniversary of insuring America is available athttp://www.zurichna.com/100.


text:
These days i'm programming in and learning about Objective-C and Cocoa. Yesterday, i stumbled upon a blog entry providing The Cocoa Memory Management Regular Expression, that is, a simple regular expression that matchs (most of) the OpenStep functions allocating memory that must be explicitly de-allocated. Here's the regexp in question:
An immediate application of this regexp is, of course, providing some sort of visual warning to remind you that memory allocation is at play. In Emacs, a way to do that is to fontify the keywords in question using an special face (font-lock-warning-face, for instance). As it happens, this is very easy to do: just call font-lock-add-keywords with the appropriate parameters:
(font-lock-add-keywords 'objc-mode '(("\\\\<retain\\\\>" 0 font-lock-warning-face) ("\\\\(\\\\<\\\\(alloc\\\\|new\\)\\\\w*\\\\)[]:]" 1 font-lock-warning-face) ("\\\\(\\\\w*[cC]opy\\\\w*\\\\)[]:]" 1 font-lock-warning-face)))
Each entry in the association list above consists of a regular expression, the group inside it to be hightlighted (0 means the whole match) and the face used for the highlighting. C-h f font-lock-add-keywords RET for extended help, including further examples (for instance, to highlight your to-dos).


text:
There are 1 enteries in mobiledev's guestbook
Hello; How are you?
Hope you are fine? It is my wish
to say hello to you , please write me on my
mail so that we can no each other and i will sent to you my
pictures,My name is royal baby girl,Please write me,
( firstname.lastname@example.com )
I wish you the best of good luck and sucese of life
have a sweet day, hugh you with kiss
Hope to see your lovely mail to my box
yours mis royal


text:
|Southeast Spotlight
Freda the Duck Frolics at Twin Lakes
Published: 09/13/2012 12:00:00
Last Saturday wasn't particularly one of your more pleasant Juneau days weather wise; it was what many would consider to be a typical, "You wonder why we live here" drab rainy day where you just want to curl up indoors with a good book and a bowl of hot soup, it wasn't the best of days.
VIDEO: The Glacier Valley Rotary Club held their $10,000 Duck Derby last Saturday, and it was a great day to be a Duck. (Image: Rik Pruett)
It was however, a fabulous day to be a Duck! And not just any old duck thank you but indeed "Freda the Duck"; frolicking in the drizzle at Twin Lakes with five thousand of her closest friends, raising money for the charitable works of the Glacier Valley Rotary Club with their ten thousand dollar Duck Derby. Richard Burns, the President of the Club, provided us with details of the event.
"The idea behind the Duck Derby is we have Freda the Duck, who's really the mascot of this whole event. She flies in with five thousand plus of her flock and we get to pick out five winners that are going to share in ten thousand dollars cash, the first prize, Five Grand. The event was really something the club started possibly about seven or eight years ago but we have had three years off where we haven't actually done an event so this year it's really a brand new event. We started from scratch; we're doing it at Twin Lakes this year as opposed to in previous years where we've done it at Riverside Rotary Park."
And they did it up right; Freda's flock arrived in grand style with a little help from her friends at Coastal Helicopters. Once comfortably ensconced in their own protective pond, they had a chance to swim around for half an hour under watchful eyes who made sure none strayed too far. Then came the rescue of the winning ducks themselves; destined to bring a pocketful of cash to a lucky sponsor, each winning duck was in turn plucked from the lake by rescue swimmers from Capital City Fire and Rescue, then hurried away to reveal their secret number which connected them to their sponsors and ultimately the winners of the Derby. Now this is all well and good, it's a fun way to spend a rainy day outdoors and a lucky winner walks away with a pocketful of cash, but ultimately there's an underlying reason for this whole event. Mr. Burns went on to explain how it all helps the club's efforts, and what some of those efforts are.
"The reason we do events like this is to really help our fundraising effort so we do a lot of really good stuff in the community, things like the Pillars of America Speaker Series, we do the 9/11 memorial at Riverside Rotary Park, youth exchange, local scholarships. So all the money we raise at events like this really goes to help those events continue."
By: Rik Pruett - email@example.com


text:
My grandmother would tell us the story,
On each Halloween.
About something deep in those woods.
She called them Deathlies and Deadlies.
And she said they guarded 'the Witches,'
Witches with skull faces...
Sunday, November 13, 2011
Halloween 2012
My grandmother would tell us the story,
12 comments:
- Jay's Shadow said...
Damn you....
352 days till Halloween and already giving a teaser....
- November 13, 2011 at 5:42 PM
- Mantan Calaveras said...
Skull Witch is dead. Long live Skull Witch!
- November 13, 2011 at 8:18 PM
- Anonymous said...
Excellent.....I'm not the only one already planning...
- November 13, 2011 at 8:42 PM
- Goneferalinidaho said...
I like it!
- November 13, 2011 at 11:06 PM
- Marrow said...
SO excited...
Maybe this year you could keep us up to date with all the progress. Photos of half-done props and ideas for lighting, layout etc...
That would be awesome!
- November 13, 2011 at 11:19 PM
- Rot said...
I've been wanting to make the Skull Witch "universe" since I built her. And it'll be fun to complete the rest of her since she's only a bust right now.
I'm not big on build/process photos. Just ruins the magic for me for whatever reason.
But I'm sure I'll be posting some kind of teaser pics along the way.
- November 14, 2011 at 6:40 AM
- Countess VonRauber (Heidi) said...
Brilliant! I really like the skull witch =)
- November 14, 2011 at 10:12 AM
- pensive pumpkin said...
thanks for keeping the magic alive.
Happy Belated Halloween.
- November 14, 2011 at 11:45 AM
- The Gill-Man said...
VERY excited to hear about this! As you well know, the whole concept of the "Skull Witch" has been a favorite of mine since you first mentioned it ages ago! I had plans to do my own take on the idea, but alas, it never came to fruition. This is probably for the best, as your take is just incredible.
The idea of you building an entire mythology around this has me incredibly stoked. It such a simple, yet chilling, image. It lends itself to a ghostly tale to be told on a dark, Autumn night!
- November 14, 2011 at 12:15 PM
- Anonymous said...
I realy hope you post more photo's of your tinies, im in love with them and realy wanna make a few of my own.
- November 14, 2011 at 7:35 PM
- JHMDF said...
Ooooo, creatures that live in the woods and guard the witch.... You know how I like small little weird creatures.
- November 16, 2011 at 1:20 AM
- Rot said...
Nobody said nuthin about "small" creatures ; )
- November 16, 2011 at 6:04 AM


text:
Epstein Barr Virus (EBV) Specific Cytotoxic T-Cells, Relapsed Lymphoma, ANGEL
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00058617
Recruitment Status : Completed
First Posted : April 9, 2003
Last Update Posted : February 15, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Patients have a type of lymph gland cancer called Hodgkin or non-Hodgkin Lymphoma which has come back or not gone away after treatment, including the best treatment known for relapsed Lymphoma.
Patients are being asked to volunteer to be in a research study using Epstein Barr virus specific cytotoxic T lymphocytes, a new experimental therapy. This therapy has never been used in patients with Hodgkin disease or this type of non-Hodgkin Lymphoma but it has been used successfully in children with other types of blood cancer caused by EBV after bone marrow transplantation. Some patients with Hodgkin or non-Hodgkin Lymphoma show evidence of infection with the virus that causes infectious mononucleosis Epstein Barr virus before or at the time of their diagnosis of the Lymphoma. EBV is often found in the cancer cells suggesting that it may play a role in causing Lymphoma. The cancer cells infected by EBV are very clever because they are able to hide from the body's immune system and escape destruction. Investigators want to see if it's possible to grow special white blood cells, called T cells, that have been trained to kill EBV infected cells.
Purpose The purpose of this study is to find the largest safe dose of EBV specific cytotoxic T cells, to learn what the side effects are and to see whether this therapy might help patients with Hodgkin disease and non-Hodgkin Lymphoma.
|Condition or disease
|Epstein-Barr Virus-Related Hodgkin Lymphoma Epstein-Barr Virus-Related Non-Hodgkin Lymphoma EBV Positive Plasma Cell Neoplasm
|Biological: Injection of EBV Specific CTLs
|Phase 1
The investigators will take 60-70 ml (12 teaspoonfuls) of blood from the patient to make a B cell line called a lymphoblastoid cell line or LCL by infecting the blood with a laboratory strain of EBV called B95-8. The investigators will then use this EBV infected cell line (which have been treated with radiation so that they cannot grow) as stimulator cells and mix it with more blood. This stimulation will train the T cells to kill EBV infected cells and result in the growth of an EBV specific T cell line. The investigators will then test the T cells to make sure that they kill the EBV infected cells and not normal cells and freeze them.
Patients will be entered into one of three different dosing schedules being evaluated. Three to six patients will be evaluated on each dosing schedule. Escalation will continue until irreversible or life threatening side effects considered to be related to the T cells are seen.
The cells will then be thawed and injected into the patients' vein over 10 minutes, after pretreatment with Tylenol and Benadryl. Tylenol and Benadryl are given to prevent a possible allergic reaction to the T cell administration. Initially, two doses of T cells will be given two weeks apart. If after the second infusion there is a reduction in the size of the patient's lymphoma on CT or MRI scan as assessed by a radiologist, the patient can receive up to six additional doses of the T cells. All of the treatments will be given at Texas Children's Hospital or the Methodist Hospital.
Patients will be followed in the clinic after the injections. To learn more about the way the T cells are working and how long they last in the body, an extra 40 mls (8 teaspoonfuls) of blood will be taken before each infusion and then 24 hours after each infusion, 3-4 days after each infusion and at 1, 2, 4, and 6 weeks post infusion and then at 3, 6, 9 and 12 months post infusion. The blood may be drawn from the central line at the time of regular blood tests. This blood will be used to test for the frequency and activity of EBV specific T cells. A total of at least 122 teaspoons (approximately 40 tablespoons) of blood will be collected during participation in this study.
If the patient decide to withdraw at any time during the study both samples and data collected during participation will be maintained.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|13 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Administration of Neomycin Resistance Gene Marked EBV Specific Cytotoxic T-Lymphocytes to Patients With Relapsed EBV-Positive Lymphoma
|Study Start Date :
|January 1996
|Actual Primary Completion Date :
|August 2011
|Actual Study Completion Date :
|July 2014
Experimental: Injection of EBV Specific CTLs
Subjects will receive autologous EBV Specific CTLs. Patients that agree will recieve CTLs that have been marked with the neomycin resistance gene.
Biological: Injection of EBV Specific CTLs
Each patient will receive two injections, 14 days apart, according to the following dosing schedules:
Group One Day 0 2x10^7 cells/m2 Day 14 2x10^7 cells/m2
Group Two Day 0 2x10^7 cells/m2 Day 14 1x10^8 cells/m2
Group Three Day 0 1x10^8 cells/m2 Day 14 2x 10^8 cells/m2
If patients with active disease have stable disease or a partial response by the RECIST criteria at their 8 week or subsequent evaluations they are eligible to receive up to 6 additional doses of CTLs at monthly intervals-each of which will consist of the same cell number as their second injection. Patients will not be able to receive additional doses until the initial safety profile is completed at 6 weeks following the second infusion.
- The safety of two IV injections of auto EBV specific CTLs will be determined through adverse event measurement. These CTLs may be marked with the neomycin resistance gene introduced by a retroviral vector. [ Time Frame: 6 weeks ]Three patients will be enrolled at the first dose level and followed for six weeks after the second dose (which will constitute a course) for evaluation of any critical toxicity. The toxicity will be evaluated as per the NCI Common Toxicity criteria version 2.0.Any toxicity scored as Grade 3 or 4 according to this criteria will be classified as an adverse event. If no toxicity is observed in the first three patients then we will enroll another three patients at the next dose level. However, if toxicity is observed in no more than one out of the three patients then three more patients will be enrolled at the same dose level. Now if the toxicity is observed in no more than one out of the six patients then we will advance to the next dose level and enroll three new patients. If toxicity is observed in two or more patients out of six then the dose limiting toxicity (DLT) has been exceeded and the previous dose level will be considered as the maximum tolerated dose (MTD) level.
- To determine the feasibility of generating EBV specific cytotoxic T cell lines from patients with active EBV positive Lymphoma including Hodgkin Disease (HD) or Non-Hodgkin Lymphoma (NHL). [ Time Frame: 6 weeks ]
- To determine the survival, immunological efficacy and anti-tumor effects of EBV specific cytotoxic T-lymphocyte lines. [ Time Frame: 15 years ]During the course of the study the survival, immunological efficacy and anti-tumor activity of neomycin resistance gene marked EBV specific cytotoxic T-lymphocyte lines will also be studied. In order to gain reasonable insight into the anti-tumor activity and late toxicity the patients will be followed for a total of twelve weeks.In the present case, the chances of observing any late toxicity should be if anything lower, as in this case the CTLs will be derived autologously.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|Child, Adult, Older Adult
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Any patient with EBV positive Hodgkin disease or non-Hodgkin Lymphoma, or plasma cell neoplasms in second relapse regardless of age or sex, in first relapse or with primary disease or in first remission if immunosuppressive chemotherapy contraindicated, e.g. patients who develop Hodgkin disease after solid organ transplantation or if the Lymphoma is a second malignancy e.g. a Richters transformation of CLL.
- Life expectancy of greater than 6 weeks.
- No severe intercurrent infection
- Patient, parent/guardian able to give informed consent
- Bilirubin <2x normal,
- SGOT <3x normal,
- Hgb greater than 8.0 g/L
- Creatinine <2x normal for age
- Must have been off other investigational therapy for one month prior to entry in this study.
- Karnofsky score of greater than or equal to 50.
- Patient with an EBV positive NHL secondary to an acquired immunodeficiency.
- Patients who are HIV positive
- Patient, parent/guardian unable to give informed consent
- Patients with a Karnofsky score of < 50.
- Patients with a life expectancy of <6 weeks
- Patients with a bilirubin greater than 2x normal. SGOT greater than 3x normal
- Patients with a creatinine greater than 2x normal for age
- Due to unknown effects of this therapy on a fetus, pregnant women are excluded from this research. The male partner should use a condom.
Note: Patients who would be excluded from the protocol strictly for laboratory abnormalities can be included at the investigator's discretion after approval by the CCGT Protocol Review Committee and the FDA reviewer.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00058617
|United States, Texas
|Houston Methodist Hospital
|Houston, Texas, United States, 77030
|Texas Children's Hospital
|Houston, Texas, United States, 77030
|Principal Investigator:
|Helen E Heslop, MD
|Baylor College of Medicine
|Responsible Party:
|Helen Heslop, Professor, Baylor College of Medicine
|ClinicalTrials.gov Identifier:
|Obsolete Identifiers:
|Other Study ID Numbers:
ANGEL ( Other Identifier: Baylor College of Medicine )
|First Posted:
|April 9, 2003 Key Record Dates
|Last Update Posted:
|February 15, 2017
|Last Verified:
|February 2017
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
EBV Positive Hodgkin's Lymphoma
EBV Positive Non-Hodgkin's Lymphoma
EBV Specific Cytotoxic T-Lymphocytes
Lymphoma, Non-Hodgkin
Hodgkin Disease
Neoplasms, Plasma Cell
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases


text:
I have been thinking about the fact that, in an accident, the only thing keeping you from exiting through the windshield is the aluminum tube the seat slides on because the lap belt is attached to the seat.
I have been considering attaching cables or brackets to the big cross tube behind the seats. I noticed at Oshkosh a couple guys had done just that, but in different ways.
I liked the ideas, but, like the short sighted idiot I commonly am, I did not photograph this. Does anybody have photos they would like to share on a solution to this? If you don't want to publicly, maybe PM it to me with a promise I will not share anything of yours myself.


text:
Where the mower doesn't go
Our Mennonite neighbor has several small businesses and dealerships in addition to his farming operations. Along the highway beside our two mailboxes, he has several signs advertising these enterprises.
Every Saturday, one of his sons mows both sides of our shared lane, from their house, past our house, down to the highway, around the mailboxes and signs, and along the highway for fifty feet or more in both directions. One of our neighbor's sidelines is lawn mower repair, so he probably thinks that keeping the grass cut short is a good business practice.
But down by the mailbox, on the banks of the ditch, where the lawn mower doesn't go, all the plants are growing wildly. I enjoy seeing them.
And I like the little pool of water that stands in the ditch in the springtime. It's interesting. When I stop to get the mail or go for a walk down our road, I stand at the end of the culvert and peer down into the shady depths. Sometimes I see a frog or a turtle or a crawdad enjoying the water.
But even when I see something interesting, I don't go any closer. I like to look at all that vegetation on the ditch banks, but I don't want to wade through it. There's too much poison ivy!


text:
I found this photo on Pinterest, isn't it cool?
I am inspired by
* Theme (masculine)
* The color scheme (orange, brown (or grey), cream, green) These colors work beautifully for Halloween and Thanksgiving cards
* The textures (wood grain)
* The style (vintage, elegant, classy, fun and cute)
* Techniques (embossing, distressing)
* Accent possibilities (cars, peace signs)
* Paper Smooches stamp suggestions (Falling For You, Spiffy Scooters)
So friends, that's your challenge...take inspiration from this fabulous photo.
Create a NEW project (card, tag, layout, altered item, etc)
You must use at least one Paper Smooches stamp or free digi
Any stamps from "The Kim Hughes Collection" by Cornish Heritage Farms
(stamps from other companies can be used, but please make sure that PS images are easily seen)
Post your Paper Smooches SPARKS project on your blog. We would love you to include our SPARKS banner (shown on the right column) somewhere on your post. Please link to our web site: www.papersmoochesstamps.com - and include Paper Smooches somewhere on your post. Submit a direct link to your blog post using our linking system below.
(right click on the SPARKS challenge banner and save to your computer. If you have any trouble, I am happy to e-mail the image to you)
If you do not have a blog, please upload your project to our Flickr Group and link to our web site in your description. Submit a link to your gallery image using our linking system below.
Here's what you are playing for:
First place...we are choosing a PRO stamper - someone who we think is a rock star - that person wins: THREE stamp sets of their choice (a $45. value)
Second place winner is called a PRIMO stamper - who we think is super fabulous - and will win TWO PS stamp sets of their choice (a $30. value)
We will choose ONE random winner to receive ONE PS stamp set and THREE shaped card templates of their choice (a $21. value)
All skill levels are welcome. You can enter as many times as you like. We do not have challenge police, so how you interpret this inspirational piece of art...just have fun, ok?
To qualify for our random drawing, you can do any or all of the following:
- create a project using our SPARKS inspiration
- comment here and tell us that you TWEETED about our challenge
- comment here and tell us that you FACEBOOKED about our challenge
The deadline for this challenge is: Wednesday, November 2nd
The next challenge will be posted on Thursday, November 3rd
Winners will be announced on Friday, November 4th--------------------------------------------------------------------------
It brings us GREAT JOY to see you using our stamps. Thank you SO MUCH for sharing your creativity with us. We truly appreciate you!
I am honored to share our design team samples with you. You can click on the links to see more of their beautiful work.
Linda Beeson
Hope you have a blast!!


text: AuthorsPaul Joseph Watson The Cultural Significance of TikTok 17th December 2018 0 9 RELATED ARTICLESMORE FROM AUTHOR The Road To Civil War – As I Predicted Long Ago – David Icke Dot Connector Videocast Blandland CrossTalk: Is everything racist? Rep. Jim Jordan blasts Mueller for dodging questions CrossTalk Bullhorns: To The Brink CrossTalk: Antifa Terror I Love Ilhan Omar CrossTalk on Turkey: Erdogan's choice Kellyanne Conway on the feud between Trump, 'the Squad' Cruz: Freshman Dems are radical and extreme with a troubling history LEAVE A REPLY Cancel reply Please enter your comment! Please enter your name here You have entered an incorrect email address! Please enter your email address here Save my name, email, and website in this browser for the next time I comment.


text:
Business Standard, 29th Dec 07
Mr KP Singh, Secretary for Defence Production, will retire from service on 31st December 2007. His three years in the Ministry of Defence (MoD) have seen major policy changes, flowing from the decision in 2001 to allow the private sector into defence production, subject to licensing and an FDI cap of 26%. There is speculation that Mr KP Singh might go on to head a new regulatory body that is being set up to manage offsets for the MoD.
Q. Mr KP Singh, how do you look back on your tenure as Secretary, Defence Production?
The Department of Defence Production, and the companies and organisations that work under its supervision, have done a wonderful job in meeting some of the crying needs of the defence forces. There have been lacunae, there are gaps, and there are areas in which we have not been able to achieve what we should have. But the reasons for that do not lie entirely within this department. Take, for example, providing the army with the155 mm (medium artillery) gun. By now we should have been up and running in meeting the requirements of the Indian armed forces. But unfortunately, because of certain problems with the foreign company which was to have given us the technology (South African company, Denel, which was banned after an investigation was launched in South Africa for corruption in an arms contract to another country), that process of buying 155 mm guns has been stalled. So unfortunately we lost that opportunity and that gap still continues to be felt.
Q. The post-2001 liberalisation in defence production has been likened to the 1991 opening up of the Indian economy. What do you see as the major landmarks of your tenure?
Defence Production must ensure that at least 30-40% of the military's equipment remains at the cutting edge. To do this, we first changed the licensing policy in 2001. The next major reform came when the MoD amended the defence acquisition procedure and laid down a "Make" procedure for defence equipment (in Defence Procurement Procedure - 2006, or DPP-2006). This allows us to select a company, or a consortium of companies, and give them a (defence) programme to develop. This requires an enormous budget, which the private sector could not afford, since there is never a certainty that the military would buy the end product. But now, 80% of the R&D funding for that project can be financed from the defence budget.
Q. But for that, the private companies have to be notified as Raksha Utpadan Ratnas (RuRs), and that announcement has been held up in the MoD.
The policy doesn't say these companies have to be RuRs. But in countries like India, you cannot do these things by pick-and-choose. There has to be a procedure by which you select a band of deep-pocketed companies, whose track records show they are good in R&D, who have the technical manpower for R&D. And that is why a group of RuRs are being selected, which can be entrusted with these vital R&D projects.
Q. But the nomination of RuRs has been stalled. It is believed that Left-backed trade unions of Defence Public Sector Undertakings (DPSUs) have held back the Defence Minister, because they fear competition from the private sector.
In a democratic society, where you have a parliamentary system, ministers always have such compulsions… let me tell you, there is total unanimity in the MoD that these are good decisions, they are good steps and we ought to take them.
Q. When will the RuRs be announced?
Sooner or later they will be… because they are good for the country in the long run. Unions will be made to realize that by suffocating a department, you cannot progress. You have to open it up so that energies of the Indian private sector are also made to play an active role in meeting the requirements of the Indian defence forces. There is space for (the DPSUs, the Ordnance Factories as well as the private sector).
Q. One of the basic conundrums of Indian defence equipment planning is that we are constantly trying to put in place a set of procedures that remove all subjectivity, and make decision-making completely objective. But a lot of defence decisions are inherently subjective; they can never be entirely objective. And since MoD officials are reluctant to make hard subjective judgements, decision-making slows down. (Former Defence Minister) George Fernandes has spoken about bureaucrats' fear of the "Three Cs" (the CVC, the CAG and the CBI)
Subjectivity cannot be scoffed at, or wished away. But subjectivity is of many types. There can be 100% subjectivity, there can be 20% subjectivity, and there can be 5% subjectivity. Any decision that anyone makes --- even something as simple as which medicine to take, which antibiotic to take, what quantity to take --- is also subjective. So subjectivity will always be there.
Q. But this insistence on procedures that are completely objective, and in accordance with a rulebook, has resulted in decision-making paralysis in the MoD, hasn't it?
Let me tell you, there is no decision-making paralysis. There are genuine fears that if there is a wrong thing done --- supposing some company has been caught doing some underhand dealings that are not as per our procedures --- obviously there is a big question mark over dealing with that company. But our big quandary is: at what stage should you take the decision not to deal with that company. In some cases, e.g. the recent decision to order re-tendering for the army's light helicopters, there is no problem. Since the order had not been placed, we could simply order re-tendering. But there are cases when you have gone ahead and placed the order, and then you come to know --- either through your channels, or through some investigative agencies --- that something really objectionable has happened. In that case, the decision to cancel the order sometimes has an impact on the Department of Defence Production, because often technology has to be taken from the vendor in order for production to start. So the whole process gets stalled. These are some of the hiccups, but in a sensitive area like defence, there are no shortcuts to success and we cannot say we need an environment in which whatever we say is right.
Q. There are other democracies. The UK, France, all these countries make the hard decisions of defence.
In those countries also, they sometimes reach a stage where they are bogged down with something or the other. There are concerns.
Q. It has been mooted that we need a completely autonomous Department of Defence Procurement.
No, I don't agree. You don't need an environment that absolves you from all responsibility. It never works. I personally think our systems are very good, decision-makers are decisive, and whatever best is to be done for the defence forces, the minister and secretary and the service chiefs also, they take the right decisions.
Q. The other important policy area that suffers from gridlock is offsets policy. Many prospective vendors, particularly those who will bid in March 2008 for the Medium Multi-role Combat Aircraft (MMRCA) contract, are waiting for changes which, they have been told, are coming soon.
Offsets policy is already in place… and there is no reason why MMRCA vendors have to fear that indecision on the offsets front will bog them down. What they are looking for are policy changes. We have to see whether the policy changes demanded by them are good for us. Those policy changes may be good for Chile, or for Poland, but not good for India. (On the other hand), some of those changes are worth implementing. So we are in the process of making decisions for bringing about changes to the offsets policy, which we think are in the long run good for running this offsets business. These decisions are in the final stages of being taken, and when they are taken, there will be amendments to the offsets procedures.
Q. But there is a March 2008 deadline, when the MMRCA bids must be submitted. For example, if you allow Transfer of Technology (ToT) to be counted as offsets, that will make a substantive difference to the way vendors' bids are structured and submitted. So the vendors' requests for early decisions are not unreasonable.
These are unfounded fears, in my opinion. When we ask for bids, we clearly spell out in the Request for Proposals (RFPs) what is required from the bidder. Sometimes we may ask for a product in "fly-away" condition, i.e. totally built. In such cases, no ToT is required, or sought. In other cases, we may want to build the aircraft, and we want maintenance ToT or production ToT. In that case, our RFP asks for specific technologies, and the vendors put a price on it. Nobody gives technology gratis… it comes with a price. Either you give them barter in offsets, or you pay hard cash for that technology.
Q. Are you saying that the changes in the offsets policy, as and when they are announced, will not be of a nature that will affect the bids and offsets proposals of the bidders.
The type of policy we have made, towards which I am a great contributor, has brought great dividends. The first big thing we have done in the offset policy is that the foreign vendor is not being guided by any authority to select an offsets partner. We've given freedom to the offsets bidder to select his partner. In the field of aeronautics, we have made an exception. In the MMRCA programme, we have said that technology will be given to HAL. That is primarily because there is no other aeronautical capable company in the country today who can produce a fighter jet. There is only HAL. That is why an exception has been made in this case. In other cases (such as the offsets for the Medium Range Radar), you've seen Israeli company (ELTA) select L&T and Astra Microwave as its offsets partner. It is entirely the due diligence of the foreign vendors that has brought them to this choice. It's a great choice: from the whole firmament of Indian public and private industry they can choose their own partners, who can give them (products) at the right price and the right delivery schedules.
Q. Have we considered the laws and regulations on the foreign vendors' side? For example, there are foreign laws and regulations that do not allow the transfer of high technology to a company in which the foreign company holds only 26%, which is the maximum that they are allowed.
Defence is an area in which it is inappropriate to increase foreign holding beyond 26% for various reasons. But, in some exceptions, like for the JV with Russia to manufacture the Multi-Role Transport Aircraft (MRTA), we have gone to the cabinet and obtained dispensations. HAL and French company Snecma were allowed to form a 50-50 partnership for manufacture of aircraft engines. Brahmos missiles are manufactured by a 50-50 Indo-Russian partnership. Similarly, if high technology is offered to India, and if 26% (foreign equity restriction) is an impediment, we can consider increasing the foreign share to 50%, depending upon the importance of that technology. We are willing to take the extra effort of going to our highest policy-making bodies and getting the approval for that.
Q. Currently, offsets are handled by the Defence Offsets Facilitation Agency (DOFA), which is neither equipped, nor staffed, to undertake such a huge job. In just the MMRCA contract, they will be required to evalute $30 billion worth of offsets proposals --- six vendors, each submitting $5 billion worth of offsets proposals. How can DOFA, in its current form, handle all of this?
We are already in the process of understanding the ramifications of this whole responsibility. And we are very much in the process of creating a body, which will have the wherewithal to cope with the workload that offsets are going to throw up. A committee has been set up to understand the problems and to sort them out. There is unanimity in the MoD that neither DOFA, nor the Director General (Acquisitions) can handle such a large volume of independent work. So an exercise is going on to identify a suitable structure for this.
Q. What timeframe are you looking at for announcing the new body?
Very shortly. 15-20 days… one month, maximum.
Q. Are you going to require legislation to be passed in parliament for this?
Maybe. But it may not be required.
Q. Will private industry, or foreign vendors, have a place in this body?
This is a purely MoD housekeeping function, keeping track of those (offsets) investments. The projects that are set up will have to produce and export for five or ten years. We have to keep track of how much they have exported, how much they have banked, how much they are carrying forward. This will become a major housekeeping function. And then there will be grey areas sometimes. Policy will need to be interpreted. In addition, there will be certain cases that fall outside existing policy… so decisions may have to be taken about how to deal with such cases. This organisation will play a very important role in advising the government what is in the best interests of the country. But foreign vendors and private companies --- they have no role to play in this body.
Q. Another key amendment to the offsets policy, which vendors are waiting for, is the announcement to allow offsets banking. When is the MoD going to announce it?
It will happen. Some of the vendors' suggestions (on offsets policy changes) are worth following, we realise that. There is unanimity in the MoD that we should allow ToT and offsets banking, and we will. These things take time to implement, and there is a desire not to announce changes piecemeal, but to announce them all together. A holistic decision will be taken very soon.
Q. There is a suggestion that grassroots defence industry must be built up by stipulating a percentage of offsets that must go into defence R&D or small and medium enterprises.
No, we have no such stipulation in our offsets policy. Social justice, or the development of industry is not the role of this ministry. We are willing to build up any industry that can play a meaningful role in defence.
Q. Evaluating the technology that we are offered under ToT… that's a problem that the MoD is grappling with.
Evaluating technology is a very important aspect. And you have to select your best people who are capable of assessing technology. The DPP-2006 has laid down that in all such matters, a committee under DRDO will make a recommendation as to what shall be the treatment given to a particular technology item.
Q. Is there a proposal to formalise that in the shape of a Defence Technology Procurement Board?
It is already formalised. The RM has approved this procedure.
Q. What about in a more pre-emptive way, by laying down that these are the technologies that we should be looking for through offsets, when we procure some equipment.
I already mentioned that each RFP, which is the starting point for procuring an item, clearly spells out which are the technologies that India is interested in buying.
Q. Other than the technologies that are related to a contract, there are other critical technologies that India might need, e.g. materials technology, fundamental science, etc. India might want to obtain those through the opportunities that offsets provide.
You cannot ask the vendor to give you what he does not have himself. The vendor who is supplying you, say the MMRCA, does not develop the materials technology. He buys it from some third party. You cannot place on him the obligation to give you that. What we require, we have to search it out ourselves. Nor are such technologies freely available; most countries restrict them. There is a continuous effort to get those technologies. If we are not getting it, there are obviously other factors.
Q. So something like a High Level Technology Steering Committee… you don't envisage something like that.
There is a very high level committee like that under the DRDO. It will become a standing committee when cases like this will come. The committee is there.
Q. There is also a suggestion that the MoD could have an Offsets Fund, which could subsidise high risk R&D and SMEs. Vendors would be permitted to contribute to this fund as a means of discharging a laid down percentage of their offsets obligations.
We have no desire for such an option. We have a separate budget for our own R&D. This must be an idea in the minds of vendors. These are all short-term concepts for discharging offsets obligations. Offsets obligations cannot be discharged through contributions to funds; they will have to be discharged the hard way, through direct investments into defence production.
Q. Finally, the rumour is that, after you retire, your expertise as one of the architects of the offsets policy will be utilised by appointing you to head the new expanded DOFA.
I am very satisfied with what I've achieved in Defence Production. I am not seeking anything more.
Q. Are you saying that you will not head the new offsets organisation? Do you rule it out?
I'm only saying that I have done my job to the best of my abilities.