That  of  the  cell  of  the  bli«)d  in  piTnici<nis  anaemia  is  more  often  ovaL
nnich  less  di^inct  in  the  fre.'^li  blood  and  stains  much  fainter  in  the
smear,  has  a  less  definite  nuclear  mcmbr.inc  and  chromatin  stnictiire:
the  cell  looks  flabbier:  but  these  differnices  are  slight  and  inconstant.
Tlic  sisiiificancc  of  ihc  appeafaiice  of  ineKa''>l>'it'"'  i"  the  lilooti  h.i»  bten  tli*
tubjecl   nf   dispiile:     Kliilicti.   conkidcnrig   thai    iticy    never   occur    in    tlic   noniffl
1m>iic- marrow  o(  nn  Ailiill.  t;cllcv«9  tliciii  tii  be  the  product   uf   a   inuKaloliIa*t)C
degeneration  of  Ihin  lissuc  due  to  .1  toxinc.  a  rciertion  to  the  cnibrioiiic  (imib-
tiim,  and  oiliert  sty  "  to  llic  amptiiblaii,"  and  that  any  atTcin|iti>  10  break  down  tht
dhtinctiun   lielwccn    nonnoliluiii   and    nieKalublasU    fail    (torn    the    faci    iliat  in
pcrnicioii)'  ana-mia  tlic  U\m(\  is  mi;([alr.bla>.iii.-,      (\Vc  arr  incTintd  to  ilimk  that  \\v
expression  "  Tci'crtioii  (o  the  anipliiluan  lype  of  Irfood"  h  much  too  often  atrt
Tbe  only  sniphitoii   we  tisvc  studied  wliose  blood  resembles  Itiat  of  pernicioui
Anarmis  !«  the  t>alraclioicp«.  and  one  would  hardly  call  an  tixmoglotiinKniia  1
"reversion."  Rllhnngh  ihnt  i*  llie  blond  condition  in   'onie  nv>rm%  hence  could  »
ea*ily  be  called  a  "harking  back")   Such  mevntohlattic  degencraticHi   may  exptkin
their  larie  numbers  in  the  marrou"  of  pemtcioiii  anicnita  and  some  oltier  cimdilion*.
