signs  of  disease  were  obviously  of  old  standing,  and  seldom
appealed  to  the  naked  eye  by  indications  more  obvious  than
a  slight  pitting  or  puckering  of  surface.  The  subject  became
endowed  with  renewed  interest  when  I  afterwards  had  an
opportunity  of  examining  the  digestive  organs  of  children  who
had  suflfered  during  infancy  from  severe  catarrh  of  the  alimen-
tary tract,  and  in  whose  stomachs  well-marked  patches  of
cirrhosis  could  be  detected  with  the  microscope.  In  these
cases  also  the  signs  of  disease  were  found  chiefly,  though  not
exclusively,  near  the  lesser  curvature  of  the  organ.  That  this
particular  region  of  the  stomach  should  so  often  present  the  relics
of  former  mischief  is  hardly  a  matter  for  wonder  when  it  is
remembered  that  the  increase  in  the  size  of  the  organ  which
occurs  after  the  second  year  of  life  mainly  involves  the  cardiac
and  middle  thirds  of  the  viscus,  and  that  consequently  any
permanent  damage  done  to  the  mucous  membrane  in  early
infancy  would  always  be  most  conspicuous  in  the  pyloric  or
least  altered  portion  of  the  organ.
