mocfa  mfiering  lared.  4.  Thjtt  cbe  ezteot  of  phonologi-
cal «Dta|poai«D  bctw«eo  the  two  anbatajoem  h  aoftr  Isin-
ited  that  (1)  m  rery  large  &tal  dose  of  stiTduune  ma,j  kill
W£>re  the  chlonl  luu  had  time  to  act ;  or  (2)  to  Urge  must
be  the  doee  of  dilonl  hydrate  to  aatagonize  an  exoessiro
doae  of  ■trycbuine  that  there  ia  danger  of  death  from  tho
effectJi  of  the  chloral  hydrate.  5.  Chloral  hydrate  miti-
gates the  efiects  of  a  &tal  dose  of  «trychmiie  bj  depress-
ing the  CXC6BS  of  roflex  actiTitj  excited  by  that  sabstanco,
while  0tr}'cbDine  may  mitigate  the  efi'ect:^  of  a  fiUal  dose
of  chloral  hydrate  by  roosing  the  activity  of  the  spinal
cord;  but  it  does  not  appear  capable  of  remo%'ing  the
coma  produced  by  the  action  of  chloral  hydrate  on  tho
brain."

A  careful  investigation  of  the  stippo&ed  antagonism  of
chloral  and  Btrychnine  has  been  undertaken  by  Huse-
mann.*  He  holds  that  chloral  is  an  antidote  to  strych-
nine, prevents  spasms,  and  averts  death,  and  that  it  has  a
corresponding  effect  in  the  case  of  the  strychnine  base  sold
under  the  name  of  brueine.  One  of  the  earlie-st  attempts
to  ascertain  whether  the  antagonism  existed  woa  that  of
Rajewskijf  who  found  that  chloral  prevented  or  relieved
tho  crarapa  caused  by  Btrychnine,  and  also  to  a  certain  ex-
tent the  cardiac  dc^presfiion,  but  that  slryehmne  was  not
in  the  sarae  degree  an  antagonist  to  chloral.  In  a  memoir
on  the  treatment  of  [Ktisoning  by  chloral,  ErlenmeyerJ
holds  that,  while  cljloral  is  useful  to  oppose  some  of  the
effects  of  Btrychnine,  the  converse  does  not  hold  good,
and  strychnine  is  not  useful  in  chloral-poisoning.     The


*  AnUgonlstiflohe  und  antidoUritcbeStudien,  Arcli.  furexp.  Pathol,  und
Phtraiftkol.,  Hand  vi.  p.  8-lG.
