Discovery of 3-((3-amino- <i>1H</i> -indazol-4-yl)ethynyl)- <i>N</i> -(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant
Journal of enzyme inhibition and medicinal chemistry