Supplementary Figures from A Preexisting Rare &lt;i&gt;PIK3CA&lt;/i&gt;&lt;sup&gt;E545K&lt;/sup&gt; Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in &lt;i&gt;NRAS&lt;/i&gt; Melanoma and Is Dependent on S6K1 Signaling