Paul Reubens as Pee - wee Herman (billed "Pee - wee Herman as himself ''). He sports a gray flannel suit with a red bow tie and close - cropped hair. Elizabeth Daily as Dottie Mark Holton as Francis Buxton Diane Salinger as Simone Lynne Marie as "Mother Superior '' in Kevin Morton 's film John Paragon as Man in Red Armor Judd Omen as Mickey Morelli Alice Nunn as Large Marge, the ghost of a truck driver who describes her own death in a traffic accident. The fabrication and animation for Large Marge 's transformation was provided by The Chiodo Brothers. Phil Hartman as Reporter Jon Harris as Andy Carmen Filpi as Jack Jan Hooks as Tina, a tour guide at the Alamo. Jason Hervey as Kevin Morton Tony Bill as Terry Hawthorne, an executive at Warner Bros. Cleve Hall as Godzilla, also cameos as a Satan 's Helpers Biker Gang member.
who played francis in pee wee's big adventure
Mark Holton