Record Player # Most wins Cy Young 511 Most losses Cy Young 316 Lowest E.R.A. Ed Walsh 1.82 Most no - hitters Nolan Ryan 7 Most strikeouts Nolan Ryan 5,714 Most shutouts Walter Johnson 110 Most pickoffs Steve Carlton 144 Most innings pitched Cy Young 7,354 2⁄3 Most hit batsmen Gus Weyhing 278 Most home runs allowed Jamie Moyer 522 Most complete games Cy Young 749 Lowest WHIP Addie Joss. 968 Most saves Mariano Rivera 652 Highest win -- loss percentage Spud Chandler 71.7 % Most games Jesse Orosco 1,252 Most consecutive scoreless innings pitched Orel Hershiser 59
most strikeouts for a pitcher in a season
Nolan Ryan Nolan Ryan