Kiefer Sutherland as President Thomas "Tom '' Kirkman Natascha McElhone as First Lady Alexandra "Alex '' Kirkman Paulo Costanzo as White House Political Director Lyor Boone Adan Canto as National Security Advisor Aaron Shore Italia Ricci as White House Chief of Staff Emily Rhodes LaMonica Garrett as Mike Ritter Zoe McLellan as White House Counsel Kendra Daynes Ben Lawson as Damian Rennett Kal Penn as White House Press Secretary Seth Wright Maggie Q as Hannah Wells
who plays the cdc doctor on designated survivor
Kiefer Sutherland