Drug delivery to the brain

The main function of the blood--brain barrier is to protect the brain and keep it isolated from harmful toxins that are potentially in the blood stream. It accomplishes this because of its structure, as is usual in the body that structure defines its function. The tight junctions between the endothelial cells prevent large molecules as well as many ions from passing between the junction spaces. This forces molecules to go through the endothelial cells in order to enter the brain tissue, meaning that they must pass through the cell membranes of the endothelial cells. Because of this, the only molecules that are easily able to transverse the blood--brain barrier are ones that are very lipid-soluble. These are not the only molecules that can transverse the blood--brain barrier; glucose, oxygen and carbon dioxide are not lipid-soluble but are actively transported across the barrier, to support normal cellular function of the brain. The fact that molecules have to fully transverse the endothelial cells makes them a perfect barricade to unspecified particles from entering the brain, working to protect the brain at all costs. Also, because most molecules are transported across the barrier, it does a very effective job of maintaining homeostasis for the most vital organ of the human body.

Is this statement correct "can lipid soluble drugs cross blood brain barrier"?

OPTIONS:
- no
- yes
yes
Drogleverans till hjärnan Blodets huvudfunktion - hjärnbarriären är att skydda hjärnan och hålla den isolerad från skadliga gifter som potentiellt finns i blodomloppet. Den åstadkommer detta på grund av sin struktur, vilket är vanligt i kroppen som strukturen definierar sin funktion. De täta korsningarna mellan endotelcellerna hindrar stora molekyler samt många joner från att passera mellan korsningsutrymmena. Detta tvingar molekyler att gå igenom endotelcellerna för att komma in i hjärnvävnaden, vilket innebär att de måste passera genom cellmembranen i endotelcellerna. På grund av detta är de enda molekyler som lätt kan transversera blodet – hjärnbarriären de som är mycket lipidlösliga. Dessa är inte de enda molekyler som kan transversera blodet--hjärnbarriären; glukos, syre och koldioxid är inte lipidlösliga utan transporteras aktivt över barriären, för att stödja normal cellulär funktion i hjärnan. Att molekyler måste transversalisera endotelcellerna gör dem till en perfekt barrikad för ospecificerade partiklar från att komma in i hjärnan, och arbetar för att skydda hjärnan till varje pris. Eftersom de flesta molekyler transporteras över barriären, gör den också ett mycket effektivt arbete med att upprätthålla homeostasen för människokroppens viktigaste organ. Är detta uttalande korrekt "kan lipidlösliga droger korsa blod hjärnbarriär"? ALTERNATIV: - nej - ja
Drug delivery to the brain The main function of blood - the brain barrier is to protect the brain and keep it isolated from harmful toxins that are potentially present in the bloodstream. It accomplishes this because of its structure, which is common in the body as the structure defines its function. The dense junctions between endothelial cells prevent large molecules as well as many ions from passing between the junction spaces. This forces molecules to go through the endothelial cells to enter the brain tissue, meaning they have to pass through the cell membranes of the endothelial cells. Because of this, the only molecules that can easily transmit the blood – the brain barrier are those that are highly lipid soluble. These are not the only molecules that can transverse the blood--brain barrier; glucose, oxygen, and carbon dioxide are not lipid soluble but are actively transported across the barrier, to support normal cellular function in the brain. That molecules must transversalize the endothelial cells makes them a perfect barricade for unspecified particles from entering the brain, and works to protect the brain at all costs. Since most molecules are transported across the barrier, it also does a very effective job of maintaining the homeostasis of the most important organs of the human body. Is this statement correct "can lipid-soluble drugs cross blood brain barrier"? ALTERNATIVE: - no - yes
ja
yes