Lewontin has worked in both theoretical and experimental population genetics. A hallmark of his work has been an interest in new technology. He was the first person to do a computer simulation of the behavior of a single gene locus (previous simulation work having been of models with multiple loci). In 1960 he and Ken-Ichi Kojima were the first population geneticists to give the equations for change of haplotype frequencies with interacting natural selection at two loci. This set off a wave of theoretical work on two-locus selection in the 1960s and 1970s. Their paper gave a theoretical derivation of the equilibria expected, and also investigated the dynamics of the model by computer iteration. Lewontin later introduced the D' measure of linkage disequilibrium. (He also introduced the term "linkage disequilibrium", about which many population geneticists have been unenthusiastic.)  In 1966, he and Jack Hubby published a paper that revolutionized population genetics. They used protein gel electrophoresis to survey dozens of loci in the fruit fly Drosophila pseudoobscura, and reported that a large fraction of the loci were polymorphic, and that at the average locus there was about a 15% chance that the individual was heterozygous. (Harry Harris reported similar results for humans at about the same time.) Previous work with gel electrophoresis had been reports of variation in single loci and did not give any sense of how common variation was.  Lewontin and Hubby's paper also discussed the possible explanation of the high levels of variability by either balancing selection or neutral mutation. Although they did not commit themselves to advocating neutrality, this was the first clear statement of the neutral theory for levels of variability within species. Lewontin and Hubby's paper had great impact--the discovery of high levels of molecular variability gave population geneticists ample material to work on, and gave them access to variation at single loci. The possible theoretical explanations of this rampant polymorphism became the focus of most population genetics work thereafter. Martin Kreitman was later to do a pioneering survey of population-level variability in DNA sequences while a Ph.D. student in Lewontin's lab. CANNOTANSWER

Answer this question "Did he have any other important research?" by extracting the answer from the text above.
Lewontin later introduced the D' measure of linkage disequilibrium. (He also introduced the term "linkage disequilibrium", about which many population geneticists have been unenthusiastic.
Lewontin har arbetat inom både teoretisk och experimentell populationsgenetik. Ett kännetecken för hans arbete har varit ett intresse för ny teknik. Han var den första personen som gjorde en datorsimulering av beteendet hos en enda genlocus (tidigare simuleringsarbete har varit av modeller med flera loci). 1960 var han och Ken-Ichi Kojima de första populationsgenetikerna att ge ekvationerna för förändring av haplotypfrekvenser med interagerande naturligt urval vid två loci. Detta utlöste en våg av teoretiska arbeten om tvåloksval på 1960- och 1970-talen. Deras papper gav en teoretisk härledning av den förväntade ekvilibrian, och undersökte även modellens dynamik genom datoriteration. Lewontin införde senare D:s mått på kopplingsdisequilibrium. (Han införde även termen "länkning disequilibrium", om vilken många populationsgenetiker varit oentusiastiska.) 1966 publicerade han och Jack Hubby en artikel som revolutionerade populationsgenetiken. De använde proteingelelektrofores för att kartlägga dussintals loci i fruktflugan Drosophila pseudoobscura, och rapporterade att en stor del av loci var polymorfa, och att det vid medellocuset fanns ungefär 15% chans att individen var heterozygot. (Harry Harris rapporterade liknande resultat för människor ungefär samtidigt.) Tidigare arbete med gelelektrofores hade varit rapporter om variation i enstaka loci och gav ingen känsla för hur vanlig variation var. Lewontin och Hubbys artikel diskuterade också den möjliga förklaringen till de höga nivåerna av variabilitet genom att antingen balansera selektion eller neutralmutation. Även om de inte åtog sig att förespråka neutralitet var detta det första tydliga uttalandet av den neutrala teorin för nivåer av variabilitet inom arter. Lewontin och Hubbys papper hade stor inverkan – upptäckten av höga nivåer av molekylär variabilitet gav populationsgenetiker rikligt material att arbeta på, och gav dem tillgång till variation på enstaka loci. De möjliga teoretiska förklaringarna till denna grasserande polymorfism blev fokus för de flesta populationsgenetikarbeten därefter. Martin Kreitman skulle senare göra en banbrytande undersökning av populationsnivåvariabilitet i DNA-sekvenser medan en doktorand i Lewontins labb. CANNOTANSWER Svara på frågan "Hade han någon annan viktig forskning?" genom att hämta svaret från texten ovan.
Lewontin has worked in both theoretical and experimental population genetics. A characteristic of his work has been an interest in new technology. He was the first person to make a computer simulation of the behavior of a single genelocus (previous simulation work has been of models with several loci). In 1960, he and Ken-Ichi Kojima were the first population geneticists to provide the equations for changing haplotype frequencies with interacting natural selection at two loci. This triggered a wave of theoretical work on two-locom choice in the 1960s and 1970s. Their papers provided a theoretical derivation of the expected equilibrian, and also examined the dynamics of the model through computerization. Lewontin later introduced D's measurements of clutch disequilibrium. (He also introduced the term "linking disequilibrium", about which many population geneticists have been unenthusiastic.) In 1966, he and Jack Hubby published an article revolutionizing population genetics. They used protein gel electrophoresis to map dozens of loci in the fruit fly Drosophila pseudoobscura, and reported that much of the loci was polymorphic, and that at the medellocus there was about 15% chance that the individual was heterozygous. (Harry Harris reported similar results for people around the same time.) Previous work on gel electrophoresis had been reports of variability in single loci and gave no sense of how common variation was. Lewontin and Hubby's article also discussed the possible explanation for the high levels of variability by either balancing selection or neutral mutation. Although they did not commit to advocating neutrality, this was the first clear statement of the neutral theory of levels of variability within species. Lewontin and Hubby's papers had a major impact – the discovery of high levels of molecular variability gave population geneticists abundant material to work on, and gave them access to variation on occasional loci. The possible theoretical explanations for this rampant polymorphism became the focus of most population genetics work thereafter. Martin Kreitman would later make a pioneering survey of population level variability in DNA sequences while a PhD student in Lewontin's lab. CannOTANSWER Answer the question "Did he have any other important research?" by taking the answer from the text above.
Lewontin införde senare D:s mått på kopplingsdisequilibrium. (Han införde även termen "länkning disequilibrium", om vilken många populationsgenetiker varit oentusiastiska.
Lewontin later introduced D's measurements of clutch disequilibrium. (He also introduced the term "linking disequilibrium", about which many population geneticists have been unenthusiastic.