(+) ANDE (+23.55%) Rejected an unsolicited bid from HC2 for $1 billion (+) MZOR (+29.35%) Medtronic ( MDT ) makes equity investment, agrees to assist with product development (+) ORMP (+17.05%) Reported top-line results from oral insulin study (+) PETX (+4.13%) Receives FDA approval for Entyce U.S. stock futures early Wednesday were adding to Tuesday's losses as Wall Street braced for the minutes from the mid-April Federal Open Market Committee meeting. Although prime minister Shinzo Abe said that the country needs to be pro-active to battle deflation, the Nikkei ended the day in the red.