Alphabet (GOOGL) closed down more than -2%, and Microsoft (MSFT) and Meta Platforms (META) closed down more than -1%. Also, mega-cap technology stocks retreated Tuesday and weighed on the overall market on concern that global central banks will have to keep interest rates higher-for-longer to combat inflation. ResMed (RMD) closed up more than +3% to lead gainers in the S&P 500 after Goldman Sachs said it sees less impact from weight loss drugs on the obstructive sleep apnea market.