On Jan. 28, 2021, shares of video game retailer GameStop (NYSE: GME) would top $483 -- more than 24 times the $20 it was trading at less than a month earlier to start the year. Although Canopy Growth stock is getting close to five-year lows, betting on its business and that marijuana legalization will happen this year is not a risk worth taking. Plus, inflation and record-high mortgages will likely result in less savings and money for investors to spend on stocks, especially on two risky, cash-burning businesses like GameStop and AMC.