The company has expanded the international reach of the CUSA platform and registered DuraGen, DuraSeal, Mayfield and Duo LED lighting in the EMEA and Latin America. However, the challenging macroeconomic scenario, specifically in the Asia Pacific and Europe, is driving higher-than-anticipated inflation in terms of raw materials and labor costs. Higher freight costs, ongoing labor inflation and manufacturing and supply-chain inefficiencies continued to put significant pressure on Integra’s margins in recent times.