The top drag on the STOXX index was Swiss drugmaker Roche ROG.S, down 1.0%, after Societe Generale downgraded the stock to "hold". The closely watched U.S. jobs data on Friday will give fresh clues on the pace of recovery in the world's largest economy, as well as signs of higher inflation at a time when investors are worried about an early tightening of monetary policy. French spirits group Remy Cointreau RCOP.PA rose 3.9% as it topped estimates for full-year operating profit growth and handed investors an 85% dividend hike.