On the other hand, some tech shares retained their strength following strong earnings from Nvidia NVDA.O with Keyence 6861.T up 1.7% and Murata Manufacturing 6981.T adding 1.4%. The setback came after U.S. stocks ended lower overnight, capped by worries the U.S. Federal Reserve may have to raise interest rates more aggressively in the future to tame inflation. Eisai 4523.T dropped 7.4% after a European Medicines Agency panel voted against approval of Alzheimer's drug the Japanese drugmaker developed with Biogen Inc BIIB.O.