While Pets.com may have been ahead of its time, online retailer Chewy (NYSE: CHWY) -- which spun off from PetSmart into a public entity in 2020 -- has had some success, in part thanks to a pandemic-driven turn toward more use of e-commerce. CEO Sumit Singh blamed Chewy's third-quarter negative earnings results on ongoing supply chain disruptions, labor shortages, and higher inflation. Investors seeking businesses that can circumvent macro-level issues like inflation and supply chain bottlenecks probably won't find a solution in Chewy.