Adobe Inc ADBE.O gained 5.1% after the company forecast first-quarter profit above expectations. By Shubham Batra and Ankika Biswas Dec 16 (Reuters) - Wall Street's main stock indexes were set to extend losses on Friday as fears of a looming recession, sparked by the Federal Reserve's relentless battle against inflation, hammered sentiment. Investors are trying to come to terms with Fed Chair Jerome Powell's recent comments, signaling more policy tightening ahead, and the central bank's projection that interest rates would breach the 5% mark in 2023, a level not seen since 2007.