Project Summary Most kinase inhibitors target the ATP binding site, and frequently inhibit numerous kinases in the human kinome. Due to the nature of pan-kinase inhibitors,
kinase selectivity is often compromised. In addition, many kinase inhibitors are not selective for the intended target, and can inhibit other kinases. Therefore, there is a need for kinase inhibitors that are selective for the intended target. The goal of this proposal is to develop a novel class of kinase inhibitors that are selective for the intended target