Thyroid hormone T3 acting through the thyroid hormone alpha receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse.
The neonatal spleen environment is a critical regulator of erythropoiesis. In the present study, we investigated the role of thyroid hormone (TH) in the neonatal spleen environment. TH-deficient (TH(-/-)) mice were generated by gene targeting. TH(-/-) mice were born at the expected Mendelian