Pulmonary lesions and autoimmune reactions after long-term nitrofurantoin treatment.
Hypersensitivity reactions in two women with pulmonary lesions, autoimmune reactions with positive
antinuclear antibodies, and a positive antinuclear antibody test in a third woman are described. The patients had been treated with nitrofurantoin for more than 10 years. The pulmonary lesions were characterized by a granulomatous reaction with a necrotizing granulomatous inflammation. The pulmonary lesions were not associated with