Introduction
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Argyrophilic grain disease (AGD) is a neurodegenerative condition associated with old age and characterized by the presence of abundant small spindle
-shaped inclusions in the cytoplasm of neurons and glial cells. The inclusions are positive for argyrophilic proteins, such as α-synuclein, ubiquitin, and p62, and are also positive for ubiquitin-immunoreactive inclusions in the form of Lewy bodies. The inclusions are also positive for phosphorylated tau