Pituitary adenylate cyclase-activating polypeptide causes rapid Ca2+ release from intracellular stores and long lasting Ca2+ influx mediated by Na+ influx
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The effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on intracellular Ca2+ concentration ([Ca2+]i) was studied in cultured rat pituitary cells. PACAP (10(-10) to 10(-7) M) caused a rapid and transient increase in [Ca2