Abstract

Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-
like syndrome. The p53 protein is a transcription factor that regulates the expression of genes involved in cell cycle arrest, apoptosis, DNA repair, and senescence. The p53 protein is also a key regulator of the DNA damage response (DDR), which is a complex network of signaling pathways that is activated in response to DNA