Plasminogen derivatives encoding kringles 1-4 and kringles 1-5 exert indirect antiangiogenic and direct antitumoral effects in experimental
models. The present study was designed to investigate the effects of plasminogen derivatives on the growth of human tumor xenografts in nude mice. Plasminogen derivatives were administered i.p. to nude mice bearing human tumor xenografts. The effects of plasminogen derivatives on the growth of human tumor xenografts were