Alpha 2 Macroglobulin (A2M) seems to play a role in the development of sporadic AD. A2M-D allele was observed as
a risk factor for AD in a Japanese population. A2M-D allele was also associated with the development of AD in a Chinese population. A2M-D allele was also associated with the development of AD in a Korean population. A2M-D allele was also associated with the development of AD in a