The effects of videotape feedback on self-concept, role-playing ability, and growth in a leaderless therapy group. Thirty-two male and female college students participated in six 90-minute leaderless encounter groups in which they received videotape feedback, leader-facilitated videotape feedback, or verbal feedback. Statistical analysis indicated that feedback through a visual medium had no effect on self-concept, role-playing ability, or group coherence. Groups within the experimental conditions were initially different in their ratings on the dependent measures. These differences were maintained throughout the experiment.


Individual differences in self-reported sleep variable correlations among nightmare sufferers. Previous research has suggested relationships between anxiety and nightmares and between nightmares and other sleep difficulties by relating measures across Ss. In the present experiment, students who reported two or more nightmares per week and who were participating in a treatment study recorded anxiety ratings and sleep observations for 8 weeks. Correlational analyses of the diurnal measures revealed within-S support for both relationships. Individual differences in the pattern of significant correlations and their treatment implications are discussed.


Success of cathartic therapy as a function of patient variables. Treated sample of 42 patients with cathartic psychotherapy and evaluated differential effectiveness on types of patients. Patients without mental disorders experienced more emotional catharsis than all others, and those with obsessive compulsive personality disorders improved more than all others as a result of emotive treatment. Contrary to popular notions, neither women nor hysterics experienced more catharsis or improved more in cathartic therapy. Although women and hysterics may cry more easily in daily life, obsessives are apparently more able to maintain focus on unhappy experiences and are therefore able to express more emotion in cathartic therapy. Furthermore, it seems that cathartic treatment is beneficial by disrupting long-standing defenses against emotional experiences, rather than by releasing stored-up affects.


Early memories and dream recall.

Early memories and dream recall. Investigated the relationship of very early memories and current dream recall. Data on early memories--for the first 3 years of life and for ages 4 through 6--were obtained by questionnaire. Dream reports were recorded at home over a 9-night period. A positive relationship was found between the number of nights for which dreams were recorded and memories reported for ages 4 through 6. Dream report was unrelated to memories reported for the first 3 years of life.


The use of Goal Attainment Scaling to evaluate a ward treatment program for disturbed children. Goal Attainment Scaling was used with behaviorally disturbed inpatient children. Staff generally underpredicted success of outcome, but were overly optimistic with four types of presenting problems and three types of goal areas. The evaluation procedure made important contributions to the processes of diagnosis and treatment planning.


Goal clarity as a component of assertive behavior and a result of assertion training. Eighty Ss were given the Rathus assertion schedule and a separate test in which their clarity of goals in various interpersonal situation was assessed. It was found that there was a direct relationship between assertion and goal clarity scores; more assertive Ss had greater goal clarity. The Rathus assertion schedule and half of the goal clarity test were administered to 24 Ss, who then were assigned randomly to 10 sessions of either an assertion training group or an insight therapy group. After treatment, the Rathus assertion schedule and the other half of the goal clarity test were administered to the 24 Ss. While there was no difference between the two groups prior to treatment, after treatment the assertion group demonstrated significantly greater goal clarity and significantly greater change on the Rathus assertion schedule than did the insight group.


Psychotherapy preferences as a function of Ss' conceptual systems. Examined the relationship between conceptual systems and preferences for behavioral or client-centered approaches to therapy. One hundred and forty college students were administered measures of their conceptual systems and of their therapy preferences; the latter included descriptions of the two therapies. Two weeks later, they were exposed to audiotaped excerpts of one of the two therapies and afterward indicated again their preferences between the two therapies. It was hypothesized that therapy preferences would be distributed nonrandomly across conceptual systems, with a greater proportion of persons in the more abstract systems who preferred client-centered approaches than in the more concrete conceptual systems. This hypothesis was supported at the .001 level. It also was found that therapy preferences were relatively stable, with very few Ss who actually changed their perferences after they had listened to the demonstration tapes.


Simplified use of the semantic differential to measure psychotherapy outcome. To initially establish the validity and utility of a simplified use of the Semantic Differential to measure psychotherapy outcome, 14 clients were administered, before and after 15 sessions of individual psychotherapy, the Semantic Differential and a symptom checklist. As predicted, results indicated that change of clients' self-constructs in a positive direction was associated with symptom reduction. Implications for psychotherapy research are discussed.


Rorschach suicide predictors: a crossvalidational study. Attempted to replicate previously reported findings that individuals who commit suicide give a greater number of transparency and cross-sectional responses on the Rorschach than matched nonsuicidal Ss. In addition, a variety of other scoring categories reported in the literature as being more frequent in suicidal Ss were compared for suicidal individuals and their matched controls. However, neither the transparency and cross-sectional category nor the other response classifications differentiated the groups. Social class and/or IQ differences in the samples used were suggested as a reason for the failure to replicate the earlier study on cross-sectional and transparency scores.


Psychological and physiological changes during tobacco-abstinence in habitual smokers. Effects of 4 days of abstinence from tobacco smoking were examined in 11 habitual smokers at their usual place of work and related to smoking habits and attitudes toward smoking as studied with the aid of a questionnaire. Results showed that adrenaline and noradrenaline excretion decreased, while performance on cognitive tests was unaffected. Irritation, disturbances in social relations and activities, and lack of needed social support were shown and reported frequently.


Alpha biofeedback therapy in alcoholics: an 18-month follow-up. In an earlier study on patients with alcohol problems, an experimental group given 10 hour-long alpha biofeedback training sessions showed greater improvement on State and Trait Anxiety scores than did a control sample. In the present study an 18-month follow-up was done on those Ss. The differences between the experimentals and controls in State and Trait Anxiety after 18 months were essentially identical to the differences between them immediately after treatment, which indicates that alpha training had long-range therapeutic effects. A difference between the groups on the Alcohol Rehabilitation Followup Questionnaire also suggested that alpha training may have been associated with some reduction in alcohol consumption as well.


Systems releasing action therapy with alcoholics: an experimental evaluation. Described Systems Releasing Action Therapy (SRAT) and a controlled study that evaluated its effectiveness. The therapy combines physical and fantasy exercises and has its roots in the Bioenergetic and Gestalt traditions. To evaluate its effectiveness, 56 patients who were receiving treatment for alcoholism were assigned randomly to therapy and control groups. On 3-week follow-up, the therapy sample showed significantly more improvement than the controls on measures of blood pressure, physical symptoms, anxiety, hysteroid tendencies, disturbed feelings and self-image. Suggestive differences (interactions significant only at the .20 level) in favor of the therapy group also appeared on measures of vital capacity withdrawal, excessive drinking, anhedonia and four neurosis-oriented MMPI scales. However, 6-month follow-up data were relatively unimpressive. The results suggest this type of therapy is an effective one, at least for the short term.


Odor and marijuana intoxication.

Odor and marijuana intoxication. Assigned 48 volunteer adult males to four groups: a marijuana high dose, a marijuana low dose, a placebo, and a coltsfoot group. Each S participated in two 80-minute sessions; one involved listening to music, socializing, and smoking the drug, and the second was identical to the first with the addition of two extra placebo cigarettes which contained finely cut amounts of human hair. The odor of burning hair was rated previously as quite aversive by non-intoxicated Ss. Contrary to expectation, Ss in the odor condition indicated on self-ratings that they became significantly more intoxicated after the smoking of the hair cigarette. The opposite effect was found with a pulse rate measure. An additional 24 Ss were divided into high and low dose marijuana groups and run in an odor session, in which they were informed prior to smoking of the hair content. Heart rate for these Ss decreased significantly more than for the comparable uninformed Ss, although self-ratings continued to reflect increased intoxication.


A further look at the Institutionalized Chronic Alcoholic Scale. Investigated a newly developed MMPI scale--the Institutionalized Chronic Alcohol Scale (ICAS)--designed to separate alcoholics from neurotics. With a sample of 75 alcoholic and 50 neurotic male Veterans Administration Hospital inpatients, the ICAS was found to separate the two groups, correctly identifying 78%, but was slightly less effective than two other previously used alcoholism scales by MacAndrew (Amac) and Holmes (Am). Data from 30 male Veterans Administration Hospital heroin addicts lend some support to the statement, which appears in the original article, that the ICAS should not be used to distinguish between alcoholics and people other than neurotics.


Goal choice of alcoholics: a comparison of those who choose total abstinence vs. those who choose responsible, controlled drinking. Examined possible pre-treatment differences between alcoholic veterans who choose total abstinence and those who choose responsible drinking as their drinking goal. The two groups were compared on a variety of behavioral, cognitive, affective, and demographic characteristics. It was found that those who choose responsible drinking had a significantly shorter history of abusive drinking (6.5 years vs. 11.5 years) and more education (12.5 years vs. 10.8 years). In addition, the responsible drinking group showed a stronger belief that their chance for success was 100%.


Comparison of two alcoholism scales with alcoholics and their wives. Both partners in 36 alcoholic marriages responded to two different alcoholism scales, the Michigan Alcoholism Screening Test and the MacAndrew Alcoholism Scale. Multiple regression analysis determined that each scale was predicted differentially, but that characteristics of the wives accounted for considerable variance of the husbands' test scores and vice versa.


A comparison of moral reasoning in drug addicts and nonaddicts. Assessed moral reasoning of 20 male addict patients and 17 nonprofessional male hospital employees by Kohlberg's methods. The mean level of moral reasoning of the drug addict group (2.97) was not found to differ significantly from that of the nonaddict comparison group (2.88). Furthermore, moral reasoning in addicts was not found to be related significantly to a number of background and personality characteristics. The findings, therefore, indicated that moral reasoning and moral behavior are not related significantly in drug addicts. It was concluded that the deviant behavior of this group is more likely the result of a deficiency in ego controls.


Will clinical psychology survive in the Soviet Union? Sovient psychologists who are working in clinics and psychiatric dispensaries call themselves "pathopsychologists," and they are, at present, in a rather difficult position. This paper will attempt to outline the position of clinical psychologists in the Soviet Union (USSR) and the nature of their problems and, also, to give an impression of (1) the tasks of clinical psychologists; (2) their struggle to regain the status of an independent profession; and (3) their struggle to keep clinical psychology an independent science.


Utilization of offender case information by "lenient" vs. "punitive" clinicians. Presentence evaluations conducted by psychologists and psychiatrists (clinicians) and correctional counselors (caseworkers) were subjected to multiple regression analyses in order to specify the relative contribution of inmate characteristics (offense severity and recidivism probability) and decision-maker response biases to sentencing recommendations. Although both groups of decision-makers showed a response bias effect for cases that were difficult to discriminate, the effect was generally larger for clinicians than for caseworkers. Response bias (lenient vs. punitive) was not associated with type of clinical judgment model (linear vs. configural) or predictability of recommendation, although it was associated with the degree of relative weighting of the two independent variables and, in the case of extremely punitive decision-makers, with the tendency to utilize only one evaluative dimension (offense severity) to the exclusion of the other. Furthermore, it was found that inmates who committed the most serious offenses were exposed selectively to those decision-makers most likely both to place exclusive emphasis on offense severity and to recommend relatively punitive case dispositions. The need for an accountability system designed to minimize the effects of the response biases of correctional decision-makers was discussed.


Flucloxacillin in bone.

Flucloxacillin in bone. Ten patients undergoing total hip replacement for osteoarthritis were each given intramuscular flucloxacillin about two hours preoperatively; bone and serum were sampled simultaneously at operation. Trabecular and compact bone were separated, partly dried, reduced to powders, and then extracted with buffer. The concentration of flucloxacillin in bone washings and serum was determined by well-diffusion assay. The mean concentration of flucloxacillin in serum was 8.9 mg/l, in trabecular bone washings, 1.3 mg/l, and in compact bone washings 0.9 mg/l. The amount of blood contaminating the bone washings was measured, and was calculated to account for at most 26% of the flucloxacillin present. The significance of these findings is discussed in relation to the prophylactic use of flucloxacillin in hip replacement surgery.


Quantitative histology in giardiasis.

Quantitative histology in giardiasis. The Weibel graticule was used to assess quantitatively histological changes in proximal jejunal mucosal biopsies from patients with Giardia lamblia infections. Most had malabsorption. A group of patients who had mild abdominal symptoms but no intestinal infection and normal absorption were the controls. There were significant differences in mean surface area (SA) measurements between patients with giardiasis and severe malabsorption and controls (P less than 0.001) and infected patients with normal absorption (P less than 0.05). SA measurements correlated significantly with D-xylose excretion results (r = 0.55; P less than 0.01) and daily facal fat output (r = -0.61; P less than 0.001). Significant correlations between duration of symptoms and SA measurements (r = 0.43; P less than 0.05) and D-xylose excretion (r = 0.43; P less than 0.05) in giardiasis suggest that histological and functional impairment are maximal soon after infection and resolve in time. Treatment with metronidazole or mepacrine was associated with a significant increase in SA (P less than 0.05) in patients with severe malabsorption but there was little change in SA in a similar group of patients who received tetracycline. The Weibel graticule was found to be useful in assessing the severity of histological changes and in following changes after treatment.


Upper respiratory tract and aural flora of saturation divers. The conditions of helium saturation diving promote the proliferation of Gram-negative bacterial species in the external auditory meatus of divers. These changes in flora occurred in the absence of operational diving, that is, no contact with water. The colonising bacteria were autogenous in origin and cross-colonisation was observed between divers. On return to normal atmospheric conditions the aural flora became predominantly Gram-positive again within 48 hours.


Detection of rubella haemagglutination-inhibition (HAI) and virus-specific IgM antibody using trypsin-treated human group O erythrocytes in the HAI test. The modification of the standard rubella haemagglutination-inhibition (HAI) test using trypsin-treated human group O erythrocytes instead of chick erythrocytes was evaluated. In a comparative study we found that, of 816 samples tested by both methods, the titres of 807 (98.9%) sera were in close agreement within an acceptable twofold difference. Trypsin-treated human group O erythrocytes usually provided titres that were twofold higher than those obtained with chick erythrocytes. In general, a very good correlation between the two methods was obtained. Data are presented that emphasise the importance of trypsin treatment of human group O erythrocytes before use in the HAI method. Furthermore, we found that trypsin-treated human group O erythrocytes can be stored for periods of up to 30 days and used in the HAI test without any appreciable loss of sensitivity or specificity. Moreover, we replaced chick erythrocytes with trypsin-treated human group O erythrocytes in the sucrose density gradient/HAI method used for the detection of rubella virus-specific IgM and found it to be a very satisfactory method. In view of these findings we recommend that trypsin-treated human group O erythrocytes should replace chick erythrocytes in the standard rubella HAI test since the former provided not only a more sensitive, more economic, and less time-consuming method but also a technique which is as specific as that using chick erythrocytes.


Measurement of ferritin in serum by radioimmunoassay. A method for the measurement of circulating ferritin concentrations by direct radioimmunoassay is presented. The method described is simple to operate, precise, and sensitive and is suitable for the routine diagnostic measurement of ferritin in either plasma or serum.


Bone marrow cellularity assessed by point-counting. A simple method for rapid point-counting of bone marrow biopsies is described; the method gave an accurate assessment of cellularity in 100 aspiration biopsy specimens. Measurements of marrow cellularity by the visual point-counting technique correlated well with those obtained with a Quantimet 720 image-analysing computer.


Giant lymph node hyperplasia of the mediastinum and refractory anaemia. An example is described of the syndrome of refractory anaemia in association with the plasma cell variant of giant lymph node hyperplasia of the mediastinum; the anaemia responded to removal of the lymphoid mass. The entity of giant lymph node hyperplasia is discussed and its relationship to the haematological syndrome is considered.


A pseudolymphomatous reaction in soft tissue associated with phenytoin sodium. A pseudolymphomatous reaction involving subcutaneous tissue and underlying skeletal muscle is described in a woman who was receiving phenytoin sodium and phenobarbitone. The histological appearance was of nodular, densely cellular tissue composed of histiocytes, plasma cells, lymphocytes, fibroblasts, and occasional polymorphonuclear cells. The significance of this finding is briefly considered in relation to the existing literature.


Splenic lipidosis after administration of intravenous fat emulsions. Spleens showing fatty infiltration and necrosis of the pulp were found at necropsy on several patients who had received intravenous fat emulsions during their terminal illnesses. The postmortem findings are described and the clinicopathological correlation is discussed with special reference to the phenomenon of creaming of the emulsion.


A clinicopathological study of liver disease in haemophiliacs. Chronic liver disease is not often reported in patients with haemophilia. Although a high incidence of abnormal liver function tests has been reported, the clinical significance of these findings and their relation to chronic liver disease cannot be established without a liver biopsy. The results of this procedure, carried out in 11 patients with severe haemophilia A and B, in whom SGOT had been persistently raised for three years, are reported. Five patients had chronic active hepatitis, four had chronic persistent hepatitis, one had cirrhosis, and one alcoholic hepatitis. No haemorrhagic complication followed the biopsy procedure, which was carried out in patients given prophylactic clotting factor concentrates. These results suggest that duration of abnormal liver function tests is likely to represent liver disease in haemophiliacs, and that biopsy should be considered to establish the diagnosis and plan a suitable therapeutic programme.


Serum total lipids, lipoprotein cholesterol, and apolipoprotein A in acute viral hepatitis and chronic liver disease. Serum total lipids, lipoprotein cholesterol, apolipoprotein A (Apo A), and liver function tests have been investigated in patients with acute viral hepatitis and chronic liver disease. Hypertriglyceridaemia, absence of alpha and pre beta bands on the lipoprotein electrophoresis pattern, low level of Apo A, and presence of abnormal lipoproteins (beta-VLDL and beta2-LP) were observed in the early phase of acute hepatitis. A positive correlation was found between Apo A and high-density lipoprotein cholesterol, and a negative one between Apo A and triglyceride, bile acids, total bilirubin, and serum alanine aminotransferase. Lipoprotein abnormalities found in the early phase of acute hepatitis are probably due to low lecithin-cholesterol acyltransferase activity. The reappearance of alpha lipoprotein and the increase of Apo A are sensitive indices of improvement of liver function. In chronic liver disease low levels of cholesterol and Apo A indicate the severity of liver cell injury.


The liver and pancreas in acute necrotising pancreatitis. Pancreatic fibrosis was found in 23 of 31 cases of acute necrotising and haemorrhagic pancreatitis; however, in the cases with a history of six days or less neither the extent nor the frequency of fibrosis differed significantly from those in controls. There was no histological evidence that duct or vascular lesions are necessary for the disease to occur. The liver was examined in 26 cases and showed cholestasis in 12, including 10 of 20 cases without a biliary aetiology and only two of six cases with biliary tract disease. In no case did the liver show specific features of alcoholic damage.


Remote metastases from intracranial tumours. A review of the primary tumours of the nervous system encountered over the past 16 years from the population of the west of Scotland uncovered only three tumours in which remote extracranial metastases had developed. In all three, there had been surgical intervention before the appearance of metastases. The findings in these patients are compared with those in other published accounts of this unusual complication.


Comparative effects of chronic ethanol and acetaldehyde exposure on myocardial function in rats. This study was conducted to compare separately the chronic effects of high blood levels of ethanol and acetaldehyde on the metabolism of the heart. Levels of ethanol and acetaldehyde were altered by administration of either 4-methylpyrazole (4-MP), a potent alcohol dehydrogenase inhibitor, or pargyline (PAR), a monoamine oxidase inhibitor that markedly increases acetaldehyde levels in the blood following ethanol administration. Measurements were made in rats consuming ethanol for three to four weeks. Mitochondrial respiration, in vitro contractility of glycerinated heart muscle fibers, and myocardial protein synthesis were determined. As compared to animals receiving only ethanol, administration of either-4-methyl-pyrazole or pargyline plus ethanol resulted in more severe damage to mitochondrial respiration and myocardial protein synthesis. The data illustrate that both acetaldehyde and ethanol in high concentrations can cause severe damage to myocardial metabolism.


Procainamide accumulation kinetics in the immediate postmyocardial infarction period. The rate of change of plasma procainamide concentration during 36 hours of constant-rate intravenous infusion was examined in five acute myocardial infarction patients. It was observed that a steady-state plasma concentration was established in about 16 hours, which is consistent with simulations of plasma concentrations based on pharmacokinetic constants obtained from studies in young healthy volunteers. However, the steady-state level that was attained in these patients was markedly higher than that which the simulations predicted. Thus, on the average, acute myocardial infarction patients have lower total body clearances of procainamide than normal volunteers.


Pharmacokinetics of prazosin in man.

Pharmacokinetics of prazosin in man. Prazosin was administered orally to 24 normotensive human subjects in the form of capsules or as a solution. Plasma concentrations indicate that drug is almost completely bioavailable from the capsules, although levels peak more slowly than from drug in solution. Drug leaves plasma with a half-life of approximately 2.3 hours. Examination of data from each subject on repeated dosing indicates considerable intrasubject consistency in pharmacokinetic response despite intersubject variability. The absence of the pharmacologically active metabolites in plasma suggests that the hypotensive response derives from drug only. Prazosin is bound to human plasma proteins to the extent of 97%.


The diuretic response in normal volunteers to a new benzylamine, 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol HCl. A phase I dose-response study of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol HCl (MK-447) was performed with the following oral doses: 6.25, 12.5, 25, 50, and 100 mg. Each volunteer served as his own control. The study was carried out in double-blind fashion on a 5-Gm Na and K diet with a minimum 2000 ml fluid intake. Urine was fractionated and analyzed for sodium, chloride, potassium, calcium, uric acid, and volume. Comparisons (MK-447 minus control values) of the 24-hour total sodium, calcium, potassium, and volume excretion rates at 6.25, 25 and 100 mg MK-447 were as follows: sodium, 195, 345, and 528 muEq/min; chloride, 191, 365, and 756 muEq/min; potassium, 77, -3, and 65 muEq/min; and volumes, 1, 3.4 and 11.7 ml/min. MK-447 did not alter calcium excretion. Uric acid excretion was observed to decrease as the dose of MK-447 was increased, however, the serum uric acid level always remained within normal limits. MK-447 did not alter the physiologic parameters but did produce symptoms of volume contraction at 100 mg. Because no further dose increase was attempted, a plateau in the dose-response curve was not reached. Comparison of 100 mg MK-447 with 80 mg oral furosemide revealed similar potency and a somewhat longer duration of action for MK-447.


Serum concentrations and inhibitory ratios during amikacin therapy of gram-negative infections. The ratio of the peak serum concentration after a 500-mg dose of amikacin to the pathogen minimum inhibitory concentration was determined for 95 patients under treatment for serious Gram-negative infections. There were 113 such ratios. The relationship of this inhibitory ratio to the clinical effectiveness and side effects of treatment with this new aminoglycoside was also studied. Mean peak serum concentration of drug was 25.8 microgram/ml, and mean inhibitory ratio was 13.0. Ninety-six per cent of inhibitory ratios were greater than or equal to 1.0. Therapy was rated totally effective in 85% of patients clinically evaluated and partially effective in 3%. Signs of renal or eighth cranial nerve impairment attributable to drug administration were confined to only two patients, and there were no other side effects. The reliability of amikacin therapy appears to be related to dependable serum levels and high inhibitory ratios.


Health maintenance organizations, 1971--1977: issues and answers. Promoting HMOs as part of a national health strategy began in 1971. An analysis of the data that have been accumulated in the intervening years sheds new light on the issues raised during the legislative hearings prior to the HMO Act of 1973. It describes the developmental process of the HMO program and suggests procedural modifications. It illustrates the difficulty of determining HMO viability during the early stages of operation, examines the varied hospital utilization rates of prepaid group practices and individual practice models, and suggests a hypothesis based on the dynamics of group process and peer pressure for HMO provider behavior.


The influence of training level and practice setting on patterns of primary care provided by nursing personnel. The influence that the level of training and practice setting have on the patterns of primary care provided by nurses at the Frontier Nursing Service (FNS) is assessed. The Frontier Nursing Service is the only available source the residents of Leslie County, Kentucky have for primary care; it utilizes nurses for the management of approximately 80% of its primary care patients. Patterns of care given by family nurse practitioners and registered nurses at FNS during 1974 were analyzed according to two tracer conditions, otitis media and urinary tract infection. Data were obtained from the encounter forms that are filled out for all primary care visits to FNS. Computerized routines were developed to group the relevant encounters into episodes of care for the two tracer conditions. Results indicate that the practice setting, rather than the level of training, has the strongest effect on the patterns of primary care rendered by nurses in a rural environment such as FNS.


The future of home health agencies.

The future of home health agencies. A multidisciplinary, multi-institutional, volunteer task force was convened by the Visiting Nurse Association (VNA) of Los Angeles to perform an evaluation of the agency and, on the basis of the evaluation, to make recommendations regarding the future potential of home health service agencies in the United States. For the VNA of Los Angeles, this use of a voluntary task force as a planning mechanism was successful; we strongly recommend its application to other agencies. The recommendations made were specific to the VNA of Los Angeles, but many are applicable to home health agencies in general. They called for an expansion of the types of services currently offered, with an emphasis on the coordinated team approach to health problems, an increased emphasis on preventive and health education services, and a movement toward providing services to groups as well as individual home care patients. The task force also urged willingness to expand services to include primary care. Modern management techniques were recommended as tools to increase the efficiency of home health service agencies. Potential new sources of revenue were proposed.


Screening for hypertension: a rational approach. A strategy for the control of hypertension in communities is presented as a staged program. Stage I consists of the evaluation and improvement of hypertension management in health care facilities. Stage II entails case-finding in health care facilities. Finally, Stage III involves targeted screening in the community. While isolated screening programs have been justly labeled "irrational", such a sequential strategy represents a highly rational approach to the community control of hypertension.


Consolidation of community hospitals.

Consolidation of community hospitals. The largest component of U.S. health care expenditures is the cost of hospital care. Evidence seems to indicate that community hospital costs can be reduced through the consolidation of some, or even all, hospital services. Although no discernible set of relevant minimal costs for the hospital industry has been established as yet, significant economies of scale can be attributed to the consolidation process. In addition to potential economic benefits, medical benefits can also accure to the community as well when inefficient, low-volume services are combined to provide more attractive resources to highly qualified specialists. Many independent community hospitals operate autonomously, often to the detriment of community health needs and economy. Those hospitals that fail to take advantage of the opportunities offered by consolidation may not be keeping faith with the population they claim to serve.


The afferent connections of the main and the accessory olfactory bulb formations in the rat: an experimental HRP-study. The afferent connections of the main and accessory olfactory bulbs in the rat were examined by injecting horseradish peroxidase (HRP) into one or the other of these structures either by microelectrophoresis or by hydraulic pressure. Alternate sections were stained with newly developed HRP-procedures using either benzidine dihydrochloride (de Olmos and Heimer, '77) or tetramethyl-benzidine. Eighteen to twenty-four hours after unilateral HRP injections confined to the main olfactory bulb, a large number of HRP-labeled perikaria appeared in the following telencephalic structures on the ipsilateral side: All portions of the anterior olfactory nucleus (AON) except its external part, the lateral transitional field (LT) between AON and the paleocortex, the whole extent of the primary olfactory cortex (POC); the medial forebrain bundle area deep to the olfactory tubercle, the nucleus of the horizontal limb of the diagonal band (NHDB) and the nucleus of the lateral olfactory tract (NLOT). A moderate to small number of labeled cells, furthermore, were seen in the dorsal (DT) and medial (MT) transition fields, the ventral praecommissural hippocampus (tt2), the ventral superficial part of the nucleus of the vertical limb of the diagonal band (NVDB), the sublenticular part of the substantia innominata (SI), the anterior amygdaloid area, the posterolateral cortical amygdaloid nucleus (C2) and the transition region (28 L') between the olfactory cortex and the lateral entorhinal area proper. On the contralateral side a large number of labeled cells were found in all parts of the AON, with especially heavy labeling in its external part. A moderate number of labeled cells could also be detected in the lateral transition  field (LT) and the NLOT. In the diencephalon and the brain stem a moderate number of HRP-labeled perikaria were observed in the dorsal, perifornical, and lateral hypothalamus, as well as in locus coeruleus and the dorsal and medial raphae nuclei. Following large HRP injections in the main olfactory bulb a moderate to small number of labeled cells were seen also in the posterior and premammillary hypothalamus and in field CA1 of the retrocommissural hippocampus on the ipsilateral side, as well as in POC on the contralateral side. It is possible, however, that the uptake of label took place in an undetected pool of HRP in the very rostal part of AON rather than in the olfactory bulb. HRP injections in the accessory olfactory bulb resulted in labeled neurons in the posterior ventro-lateral part of the bed nucleus of the stria terminalis, the nucleus of the accessory olfactory tract, the rostrodorsal portions of the medial amygdaloid nucleus, and the whole extent of the posteromedial cortical amygdaloid nucleus (C3) on the ipsilateral side. A few lightly labeled cells were seen also in the contralateral C3.


Histology and ultrastructure of the carotid sinus in experimental hypertension. Histological studies including electron microscopy were performed on the carotid sinuses of dogs with renal hypertension of 17 to 82 days duration or hypertension of two years secondary to aortic coarctation. Physiological abnormalities in the baroreceptors including resetting had been demonstrated before death. Histologically there were no qualitative or quantitative differences in the intrasinus nerve fibers of the hypertensive animals compared tp controls with normal blood pressures, and there was no evidence that baroreceptor degeneration occurred as a consequence of the hypertension. Structural lesions confined to the intima were evident in the sinus walls of some of the renal hypertensive animals whereas the dogs with coarctation showed more advanced sinus wall changes including medial calcification and enlargement of the vascular lumen.


Observations on the development of brainstem-spinal systems in the North American oppossum. The North American oppossum is born 12 to 13 days after conception and and is available for 90 days or more in an external pouch where it can be observed and experimentally manipulated. It is of particular interest that the hindlimbs of the newborn opossum are very immature and remain immobile for a week or more after birth. Degeneration techniques reveal that immature brainstem axons are present within the marginal zone of the lumbosacral cord before hindlimb movements begin (our state I) and material processed for formaldehyde induced fluorescence shows that some of them transport monoamines. Several lines of evidence suggest that part of the fluorescent axons arise within the nucleus locus coeruleus. At this early stage the electron microscope reveals that all brainstem-spinal axons are small (0.1--0.4 micrometer in diameter) and unmyelinated. By the time random hindlimb movements can be observed (stage II), brainstem axons, including those transporting monoamines, can be demonstrated to have grown into limited areas of the intermediate zone of the lumbosacral cord and to arise from most of the areas contributing to them in the adult animal (horseradish peroxidase technique). Such axons are still immature and it is not yet clear that they have formed synaptic terminals. Brainstem axons continue to grow into the intermediate zone of the lumbosacral cord for some time and come to occupy all of their adult territories before thoracic transection produces obvious change in hindlimb motility (beginning of stage III). It is still another 20 days or so before thoracic transection produces spinal shock comparable to that in the adult animal. The relatively mature use of the hindlimbs and the full expression of spinal shock correlate with changes in the technique and survival time needed to demonstrate degenerating brainstem axons in experimental material.


Categories of axons in mammalian rami communicantes. Part II. The mammalian rami communicantes consist of preganglionic, postganglionic and sensory axons. The present study focusses on the number of sensory axons in the midthoracic rami communicantes in the cat. The conclusions are that the white rami contain approximately 250 myelinated and 200 unmyelinated sensory axons and the grey rami 4 to 5 myelinated and 20 to 25 unmyelinated sensory axons. A previous study determined the numbers of pre- and postganglionic fibers in these same rami. Thus the total number of axons in these rami are as follows: for the grey rami there are: (1) 3,000 to 5,000 unmyelinated postganglionic axons, (2) 25 myelinated postganglionic axons, (3) 20 to 25 unmyelinated sensory axons and; (4) 4 to 5 myelinated sensory axons; and for the white rami there are approximately: (1) 1,000 unmyelinated preganglionic axons, (2) 1,500 myelinated preganglionic axons, (3) 2,000 unmyelinated postganglionic axons, (4) 250 unmyelinated sensory axons and (5) 200 myelinated sensory axons. The implications of these findings are discussed.


The ultrastructure of the basilar papilla of the chick. The basilar papilla of the chicken was studied by transmission and scanning electron microscopy. It is composed of two distinct types of hair cells, a tall hair cell (THC) and a short hair cell (SHC). Gradual transitions exist between these two forms. The THC occurs mainly in the anterior part of the neuroepithelium and is situated on the superior fibro-cartilagenous plate, while the SHC dominates in the posterior part and is found on the free basilar membrane. The THC is a tall columnar cell with an elongated hexagonal apical surface. One kinocilium and 150 to 220 stereocilia protrude from the center of its surface. The THC makes synaptic contact with several large afferent nerve terminals and with small bouton-shaped efferent terminals. The SHC is short and thick, having a much wider surface area than the THC. From the inferior part of the surface of the SHC 90 to 120 stereocilia protrude, whereas the kinocilium is lacking. The nucleus is located near the base of the cell. Small afferent nerve terminals and extremely large efferent nerve endings synapse with the SHC.


Morphological and electrophysiological characteristics of projection neurons in the nucleus interpositus of the cat cerebellum. The populations of neurons in the nucleus interpositus (IP) of the cat cerebellum which project to the ventral lateral nucleus of the thalamus (VL), the red nucleus (RN), the nucleus reticularis tegmenti pontis (NRTP), the pontine nuclei (PN), the inferior olive (IO), and the cerebellar cortex were identified by intracellular and extracellular injections of HRP and studied electrophysiologically. When HRP was simultaneously injected into the VL, RN, and IO, over 95% of the neurons in the IP nuclei were labeled; indicating that there are few, if any, local circuit neurons. The vast majority (86%) of the larger IP neurons (soma length greater than or equal to 20 micrometer) project rostrally to the RN and thalamus. These neurons typically have long, relatively spine free dendrites and axons which in a few cases gave rise to recurrent collaterals. Two intracellularly stained projection neurons which had exceptionally long spiny dendrites had axons which gave rise to nucleocortical collaterals in addition to several local collaterals. IP neurons projecting to the NRTP and PN were located primarily in the lateral aspect of the nucleus interpositus anterior. Electrophysiological experiments established that neurons projecting to the NRTP also project to the VL. The IP neurons projecting to the IO have small fusiform or multipolar somata, long thin dendrites, and receive excitatory inputs from the IO. At least 73% of the small neurons in the IP project to the IO, and some of these, in addition, project to the VL. There are at least three morphologically distinguishable populations of projection neurons, small IO projections neurons, and neurons with nucleocortical collaterals. The projection of the IP to diverse regions of the brain is accomplished mainly by axon collateralization, but regional and morphological specialization also play a role in the organization of the output of the IP.


Nuclei of the solitary tract: efferent projections to the lower brain stem and spinal cord of the cat. The efferent projections from the solitary complex to the lower brain stem and spinal cord were studied in the cat with the autoradiographic anterograde axonal transport and retrograde horseradish peroxidase (HRP) techniques. A revised cytoarchitectonic description of the caudal two-thirds of the complex is presented in which the complex was subdivided into six nuclei: lateral, ventrolateral, intermediate, medial, parvocellular, and commissural solitary tract nuclei. Following injections of 3H amino acids into electrophysiologically defined regions of the complex in which cardiac or respiratory units were recorded, labeled fibers could be traced to a number of sites in the caudal brain stem including the medial and lateral parabrachial nuclei, Kölliker-Fuse nucleus and the area ventral to this nucleus, lateral periaqueductal gray matter, ambiguus complex, which consists of the retrofacial, ambiguus and retroambiguus nuclei, ventrolateral reticular nucleus (in an area equivalent to the A1 cell group of Dahlström and Fuxe, '64), medial accessory olive, paramedian reticular formation, and lateral cuneate nucleus. Descending solitario-spinal projections have been traced bilaterally, but predominantly to the contralateral side, to the region of the phrenic motor neurons in the C4-C6 ventral horn, to the thoracic ventral horn, and intermediolateral cell column. Confirmatory evidence of some of these projections was obtained from a series of HRP experiments. Mainly small neurons of the parvocellular, medial and commissural solitary tract nuclei project to the region of the parabrachial and Kölliker-Fuse nuclei. The lateral solitary nucleus projects almost exclusively to the ipsilateral medial accessory olive. It was not possible to interpret conclusively the labeling seen in the medium and large neurons of the ventrolateral solitary nucleus after HRP injections made in the region of the ambiguus-retroambiguus complex due to the problem of fibers of passage. Following injections of HRP into the cervical, thoracic, lumbar, or sacral spinal cord, retrograde cell labeling was seen in the solitary complex. Cells in the intermediate and commissural nuclei were labeled after all four types of experiments. In the ventrolateral nucleus, medium sized neurons were predominantly labeled after the cervical spinal cord experiments, while large sized neurons were labeled mainly after the thoracic spinal cord injections. The potential physiological significance of these connections is discussed in terms of central control of cardiovascular and respiratory functions.


Distribution of motoneurones to the neck muscles, biventer cervicis, splenius and complexus in the cat. The distribution of motoneurones to the cat dorsal neck muscles biventer cervicis, splenius and complexus has been examined using the technique of retrograde horseradish peroxidase transport. A comparison was initially made of HRP uptake into motoneurones produced either by injecting HRP solution directly into a single neck muscle or by exposing the cut ends of motor nerves to an HRP solution. The injection of HRP into single neck muscles was found to produce widespread labelling of motoneurones presumably due to diffusion of HRP into adjacent muscles. For the examination of individual motoneurone pools the technique of cut nerve exposure was therefore used. Labelled neck muscle motoneurones ranged from 10-70 mu in diameter, but the majority of cells had diameters which were less than 40 mu. Most cells were located in the ventromedial nucleus and along the medial border of the ventral horn. In these regions there was considerable overlap between the motoneurone pools of the three neck muscles examined. In addition, some splenius motoneurones were located in the nucleus of the spinal accessory nerve. Labelled neck muscle motoneurones were also located in areas not usually considered to contain motoneurones such as the commissural and centrodorsal nuclei and in the ventral commissure.


Afferent and efferent fiber connections of the carp torus longitudinalis. The efferent and afferent pathways of the carp torus longitudinalis were studied by means of degeneration and retrograde HRP methods. Efferent projections were only seen in the most superficial layer of the ipsilateral optic tectum (stratum fibrosum marginale). Afferent pathways to the torus longitudinalis were found to originate mainly in the valvula cerebelli. Degenerating fibers course in the tractus mesencephalocerebellaris posterior within the valvula, and join the tractus mesencephalocerebellaris anterior in the tegmentum. The fibers which ascend in the tract gradually invade the optic tectum through which they are distributed to the torus longitudinalis. The remaining fibers pass through the posterior commissure and terminate in the torus longitudinalis at the rostral end of the tract. Degenerating terminals were also seen in the torus longitudinalis when lesions were made in the optic tectum, tectal commissure, torus semicircularis, and in the area between the valvula and the corpus cerebelli. The possibility of projections from these areas is discussed depending upon the results of the retrograde HRP method.


Connections of striate cortex in the prosimian, Galago senegalensis. Efferent and afferent connections of primary visual cortex, Area 17, were determined in a prosimian, Galago senegalensis, by autoradiographic methods after injections of 3H-proline or 3H-HRP. The cortical connections of Area 17 with Areas 18 and MT were homotopic and reciprocal. Projections from Area 17 terminated largely in layer IV and somewhat in layer III of both Areas 18 and MT. Most of the cells projecting to Area 17 were located in layer V of Area 18 and layer VI of MT. Subcortical projections included the reticular nucleus of the thalamus, where columns of label corresponding to injection sites were found in the caudal fourth of the nucleus. Projections to the lateral geniculate nucleus were along lines of isorepresentation and were in register with the cells projecting back to the injection site. The parvocellular layers were less densely labeled than other layers by the transport of 3H-proline, while concentrations of label were noted on the dorsal and ventral margins of the nucleus and in interlaminar regions between the internal parvocellular and magnocellular layers and between the two magnocellular layers. The pattern of terminations in the pulvinar complex suggested functional subdivisions. We have divided the inferior pulvinar into a large central nucleus, IPc, with topologically organized input from Area 17; a smaller medial nucleus, IPm, with a second pattern of input from Area 17; and a dorso-posterior nucleus, IPp, without input from striate cortex. The superior pulvinar likewise appears to have several subdivisions. One of these, a "central" nucleus of the superior pulvinar, SPc, receives topologically organized projections from Area 17. SPc is about the same size as IPc and is organized as a mirror image of IPc. Thus, both IPc and SPc represent the lower visual quadrant medially and the upper visual quadrant laterally; central vision is represented along the common border for both nuclei, while peripheral vision is represented dorsorostrally in SPc and ventrocaudally in IPc. Finally, the superficial grey of the superior colliculus receives topologically organized input from Area 17.


Organization of corticocortical connections in the parietal cortex of the rat. An analysis based on Nissl, anterograde degeneration, and succinic dehydrogenase histochemical techniques reveals that there are two distinct regions of parietal cortex which are characterized by different cytoarchitectonic features and anatomical connections. The "granular" cortical zone possesses a well-defined fourth layer composed of small, densely-packed cells, receives dense projections from the ventral posterior nucleus of the thalamus, and is essentially free of callosal inputs. "Agranular" cortical areas which surround or lie embedded within the granular zone lack a well-defined fourth layer, receive sparse projection from the ventral posterior nucleus, but send and receive extensive callosal projections. These findings suggest that thalamic and callosal projections to the parietal cortex maintain a pattern of areal segregation. The granular cortical zone, which apparently corresponds to SmI, projects ipsilaterally to motor cortex, SmII, and adjacent agranular areas. The superficial layers of the granular cortex also project heavily upon the underlying layer V. This intracortical projection is not organized in discrete clusters within the "barrel field" cortex. This suggests that the specialized organization of thalamic afferents and granule cells within the "barrel field" is not maintained in the intracortical circuitry of this region.


Effects of early monocular lid suture upon neurons in the cat's medial interlaminar nucleus. Single unit extracellular recordings, cell size measurements, and cell packing density measurements were made in the medial interlaminar nucleus (MIN) of nine adult cats that had been monocularly deprived by lid suture prior to natural eye opening. The electrophysiological properties of neurons in the nondeprived regions of MIN (areas receiving input from the non-deprived eye) remained unaffected by monocular lid suture. The latencies to optic chiasm stimulation and receptive field properties, including receptive field center size, were essentially the same as those found for MIN neurons of normal adult cats. In contrast, cells in the deprived regions were severely affected by monocular deprivation. We encountered in the deprived regions of MIN only about one half as many active neurons per mm of electrode penetration as we did in the nondeprived regions. Of the physiologically active cells remaining, about one half had abnormal receptive field and/or response properties. This resulted in a sampling density of 5.1 normal Y-cells per mm of penetration in nondeprived regions of MIN compared to 1.0 normal Y-cell per mm in deprived regions of MIN. Histological effects of deprivation were also seen. Deprived regions of MIN were distinguished from nondeprived regions in four cats by autoradiography following intravitreal injection of tritiated proline into the deprived or non-deprived eye (2 cats each). The mean cell size of deprived regions of MIN was 34% smaller than that of nondeprived regions. We did not find a difference in cell packing density between these two regions. It appears that the effects of monocular lid suture upon MIN are in most respects similar to the effects of monocular lid suture previously reported for the A laminae. Since MIN is composed solely of Y-cells, these data support the idea that the Y-pathways are more severely affected by visual deprivation than are the X-pathways. Further, since MIN projects largely outside the striate cortex, these data give the first demonstration of a primary effect of early lid suture upon extrastriate visual pathways.


Somatotopic organization of mechanosensory projections to SII cerebral neocortex in the raccoon (Procyon lotor). The pattern of projections of peripheral receptors to the neocortex in the second somesthetic receiving area (SII) was mapped in raccoons. The purpose was to determine if the projection area of peripheral receptors to the forepaw area in the SII region is disproportionally enlarged as it is in SI. Tungsten microelectrode recording procedures were used to map thoroughly the inferior wall of the suprasylvian sulcus for regions responsive to mechanical stimulation of peripheral receptors. The results show that: 1. The forepaw area in SII shows an enlargement commensurate with that found in the SI. This suggests that those factors that are selective for tactile acuity of the raccoon forepaw were operating in the evolution of SII as they were in SI. 2. The somatotopic organization of mechanoreceptive projections to SII is reversed mediolaterally compared to previous descriptions of this arrangement in other mammals: projections form axial structures lie medially and those from apical structures lie laterally along the inferior bank of the suprasylvian sulcus in the raccoon.


Spinal and medullary input to the lateral cervical nucleus. The distributions of spinal and medullary cells projecting to the lateral cervical nucleus (LCN) have been investigated in young cats and dogs using the retrograde horseradish peroxidase (HRP) technique. Labeled spinal cells, whose axons contribute to the spinocervical tract (SCT), were found at all levels of the spinal cord ipsilateral to the injection sites. No significant differences were found between cat and dog, nor between cases with single injections at different levels of the LCN. SCT cells were found predominantly, if not exclusively, within lamina IV, with some extension into medial lamina V. No apparent mediolateral or dorsoventral density gradient was observed within lamina IV; cells of all sizes were labeled. Cells in cervical laminae I and V-VII were occasionally labeled; these, however, were considered to be propriospinal, supplying afferent fibers to the C1-2 dorsal horn. Cells of origin of spinocerebellar fibers consistently remained unlabeled in cases with restricted HRP injections and minimal fiber damage in the dorsolateral funiculus (DLF) around the injection sites. These results, therefore, corroborate and refine the findings of electrophysiological studies of the SCT and the LCN. Labeled medullary cells were located in the caudoventral and rostral portions of the dorsal column nuclei (DCN; stellate and fusiform cells), the underlying n. medullae oblongatae centralis, subnucleus dorsalis (parvicellular medullary reticular formation), the marginal and magnocellular layers (both large and small cells) of the n. trigeminalis spinalis pars caudalis and also in pars interpolaris; a cluster of cells was also consistently labeled in the lateral reticular formation just ventral to pars caudalis. The projection from the DCN to the LCN was confirmed with the anterograde Nauta technique. Fiber degeneration was observed in the entire ipsilateral LCN, although it was less abundant than that observed in the adjacent C1-2 dorsal horn. These results indicate that neurons in the rostral portions of the DCN not only may affect the input to the LCN (at the level of the dorsal horn), but also the output of the LCN itself. These data also suggest the possibility of both noxious and non-noxious facial input to the LCN.


The localization of the motor neurons innervating the extraocular muscles in the oculomotor nuclei of the cat and rabbit, using horseradish peroxidase. The localization of the motor neurons innervating the extraocular muscles in the oculomotor nuclei of adult cats and rabbits was investigated by means of retrograde labelling with horseradish peroxidase (HRP). The groups consisting of the motor neurons innervating an individual muscle lay in the nucleus as elongated columns extending in a longitudinal direction. The position of each group in the transverse section varied according to the rostro-caudal level of the nucleus. In the cat and rabbit, entire contralateral innervation of the superior rectus and entire ipsilateral innervation of three muscles of the inferior rectus, medial rectus and inferior oblique were similarly observed. However, the arrangement of individual motor groups differed considerably in both animals except for the group innervating the inferior rectus which was generally found in the ventral position running through the rostral two-thirds of the oculomotor nucleus. In the case of cats, the central caudal nucleus bilaterally innervated the levator palpebrae superioris. The motor neurons innervating this muscle in the rabbit (which lacks the central caudal nucleus) formed a rostro-caudal club-shaped column close to the group innervating the superior rectus. The aberrant cellular mass in the adjoining medial longitudinal fasciculus which belongs to the medial rectus appears to play an important role in the eye movement, because it commonly appears in various animals.


A comparison of projections of entopeduncular neurons to the thalamus, the midbrain and the habenula in the cat. Anatomical studies have demonstrated that the output of the striopallidal system is distributed to two areas of the thalamus: the ventrolateral-ventroanterior and the centromedian nuclei. The two areas are involved in different ways in the control of somatic motor activity. Pallidal efferents are also distributed to a still obscure tegmental area in the midbrain, the pedunculopontine nucleus, and to the lateral habenular nucleus, a structure of the limbic system. The present study compares the projections of entopeduncular neurons to the four sites in cats. The comparison is based on an estimation of the number of entopeduncular neurons sending fibers to each site and branching to more than one site. The four projection sites were stimulated electrically in anesthetized cats and the number of entopeduncular neurons excited antidromically were counted. At least 68% of entopeduncular neurons were excited antidromically by stimulation of the ventrolateral nucleus, an equal number were excited antidromically by stimulation of the nucleus centromedian and slightly fewer but still more than 50% by stimulation of the pedunculopontine nucleus. The three sites gave rise to antidromic responses of the same entopeduncular neuron in at least 33% of the cases. Only 25% of entopeduncular neurons responded antidromically to stimulation of the lateral habenular nucleus exclusively (one-third) or not (two-thirds). Some neurons recorded incidentally in the globus pallidus responded antidromically to the stimulation sites. Neurons were also recorded in the preoptico-hypothalamic area and 67% responded antidromically exclusively to the stimulation of the lateral habenular nucleus.


Poison-based taste aversion learning in deer mice (Peromyscus maniculatus bairdi). A series of experiments tested the ability of mice of the native genus Peromyscus to form learned taste aversions. It was found that (a) the mice acquired a strong aversion after a single flavor/toxicosis pairing, (b) naive mice drinking a LiCl solution apparently began to experience toxic effects within 90 sec after the beginning of consumption, (c) the mice acquired a total aversion after a single flavor/delayed illness pairing when high doses of toxin were employed, and (d) the aversion produced by a single flavor/delayed-illness pairing was specific to the flavor paired with illness and was dependent on the contingency between the flavor and illness. Although these responses are qualitatively similar to those reported for domestic rats, the mice formed considerably weaker aversions than those previously reported for laboratory rats tested with the same weight-specific doses of LiCl.


Schedule-induced polydipsia in rats: adrenocortical and hippocampal modulation. Onset of schedule-induced polydipsia (SIP) is related to adrenal gland weight. Adrenalectomy, but not demedullation, hastened the emergence of SIP, and exogenous corticosterone administration tended to reverse this effect. Hippocampal lesions were followed by a rapid and uniform release of SIP. None of the above manipulations influenced normal (home-cage) drinking. A synthesis of present findings with the literature suggests that the hippocampus and the adrenal cortex interact and that the equilibrium established within this system is reflected, for any particular rat, in its adjunctive behavior.


Exploration and avoidance in rats with lesions in amygdala and piriform cortex. Lesions localized to specific areas of the amygdala and overlying cortex in rats produced differential effects in several behavioral tasks. Three different types of lesions were tested: central, basolateral, and cortex lateral to the amygdala. Lesions restricted to the central nucleus produced increased activity on all parameters studied in an open-field test, but the other two groups were not changed. In one-way active avoidance all three groups with lesions showed deficits. The most pronounced change was observed in the central group. All groups showed the same degree of retention loss, but in forced extinction of one-way active avoidance after retraining, the cortical and basolateral groups were most defective. A fear-reduction hypothesis is proposed for the central lesion. The basolateral and cortical areas may be more specifically involved in passive avoidance behavior.


Effect of cholecystokinin on meal size and intermeal interval in the sham-feeding rat. After 3-hr food deprivation, rats with gastric fistulas ate liquid food with the fistula closed (normal feeding) or open (sham feeding). Meal size (MS) was larger, latency to rest (LR) after a meal was longer, and intermeal interval (IMI) was shorter during sham feeding than during normal feeding. The putative satiety signal cholecystokinin (CCK, 20% pure) decreased MS and LR and increased IMI during sham feeding. After CCK (30 U/kg) the MS, LR, and IMI were the same during sham feeding as during normal feeding. The synthetic octapeptide (OCT) of CCK, which has the known biological actions of the complete hormone, reproduced the effects of CCK (30 U/kg) on MS and LR but not on IMI. Ingestive behavior was not nonspecifically suppressed by CCK or OCT because water drinking was not inhibited by CCK or OCT. The CCK and OCT were also tested for their ability to serve as unconditioned stimuli (UCS) for the formation of a conditioned taste aversion (CTA) in the 3-hr food-deprived sham-feeding rat. The OCT (30 U/kg) did not serve as a UCS for a CTA in the same sham-feeding conditions in which OCT produced normal MS and LR. Impure CCK (30 U/kg), however, did serve as a UCS for a CTA under these conditions. The differential effectiveness of CCK and OCT for IMI and CTA may be due to non-CCK factors in the impure extract of CCK. These experiments demonstrate that the preabsorptive food-contingent stimuli of sham feeding plus exogenous CCK are sufficient for normal short-term satiety under certain conditions, and they provide further evidence consistent with the hypothesis that cholecystokinin produces satiety in rats.


Environmental events that modify the catecholamine fluorescence of the A2 cell bodies in nucleus tractus solitarii. The fluorescence intensity of the catecholamine cell bodies of the A2 group--as determined by microfluorimetry--increased significantly due to exposure of the rats to the following environmental events: placement of a rat from the colony cage into a cold (4 degree C) room for a period of 10 min, isolation of a rat from the colony for 6--7 days, and satiation of gouped rats by allowing them access to sweetened milk for 15 min. The following events failed to affect the intensity of the cells of A2: reduction of the group colony size from eight to three rats per colony for 6--7 days and presentation of water instead of milk after the rats had experienced 6--7 days of milk satiation. These results indicate that aversive as well as rewarding environmental events activate the catecholamine cells of A2.


Two types of aphagia and two types of sensorimotor impairment after lateral hypothalamic lesions: observations in normal weight, dieted, and fattened rats. In two experiments, reactions to food and to tactile stimuli were examined in rats whose body weights were normal, reduced by restricted feeding (dieted), or raised by having access to palatable foods (fattened) prior to receiving bilateral lesions in the lateral hypothalamic (LH) area. Postoperative aphagia and sensorimotor impairments were less prolonged than normal in the dieted rats and more prolonged than normal in the fattened rats. The LH lesions produced a transient hyperthermia which was attenuated by dieting and facilitated by fattening. Certain motor impairments (which accompanied more posterior lesion placements), hypokinesia, and a lesion-induced exaggerated aphagia to novel foods were relatively unaffected by preoperative body weight. Depending importantly upon lesion placement, there appeared to be at least two types of aphagia and two types of sensorimotor impairment. Animals with more posterior LH lesions displayed a passive kind of aphagia and sensory neglect. These animals did not react to food or to sensory stimuli presented externally, but they chewed and appeared to swallow food placed in the mouth. Animals with more anterior LH lesions displayed an active kind of aphagia and sensory rejection. These latter animals briskly turned their heads toward food or a light touch; however, they also showed simple stereotyped withdrawal or reactions of aversion to the food, to a light touch, and to a variety of sensory stimuli. Animals with intermediately placed lesions showed symptoms common to passive and active aphagia and to sensory neglect and sensory rejection. The effects of preoperative weight manipulation on the specific types of aphagia and sensorimotor impairments are discussed.


Subamnesic cycloheximide treatment delays consolidation in mice. In the first experiment, groups of C57 BL/6J mice were given passive avoidance training and then administered different doses of cycloheximide (CYC) immediately, 30 min, or 1 hr after training. Only the highest dose (150 mg/kg) administered immediately or 30 min after training impaired memory when the mice were tested 72 hr after training. In the second experiment, mice were given a nonamnesic administration of CYC (30 mg/kg) or saline immediately after training and another injection of CYC (15 mg/kg, 30 mg/kg, or 75 mg/kg) or saline 1 hr after training. Single injections of CYC and the combination of 30 mg/kg + 15 mg/kg did not impair memory, but the combinations of 30 mg/kg + 30 mg/kg and 30 mg/kg + 75 mg/kg did impair memory. The third experiment demonstrated that brief carbon dioxide anesthetization initiated immediately after training impairs memory. In the fourth experiment, mice were given either saline or 30 mg/kg CYC immediately after training and then subjected to either air or CO2 anesthetization 30 min after training. Only the group given 30 mg/kg CYC + CO2 was amnesic when tested 72 hr after training. The results of these experiments indicate that the administration of a nonamnesic dose of CYC immediately after training renders the memory susceptible to disruption by additional doses of CYC or other amnesic treatments for a longer period of time than normal. It is suggested that CYC delays consolidation and prolongs the labile period of memory formation.


Task-dependent genetic influences on behavioral response of mice (Mus musculus) to acetaldehyde. Acetaldehyde was employed as a pharmacological agent in behavioral tests designed to assess genetic influences upon response to the drug. When used as a poison in a conditioned taste aversion study, acetaldehyde was more effective at inducing aversions in DBA/2J mice than in C57BL/6J mice. In another experiment, however, C57 mice were more affected than were DBA mice by acetaldehyde effects on loss of righting reflex. Implications for postulated genetic control of ethanol preference and neurosensitivity are discussed.


Interaction between penile reflexes and copulation in male rats. Intact, unanesthetized male rats were place in a supine position, with the penile sheath continuously retracted. Three forms of penile reflex were displayed: erections, cups, and flips. The reciprocal relation between copulation and the penile reflexes occurring in supine tests was explored in four experiments. In Experiment 1, sexual exhaustion depressed all penile reflexes, but the reflexes returned to baseline levels within 8 hr, long before copulatory potential. In Experiment 2, reflexes were depressed to exhaustion levels after fewer ejaculations than were required for sexual exhaustion, an indication that reflexes are more readily evoked during copulation than in supine tests. Experiment 3 determined that a rat's penile-reflex potential may be enhanced by placing the rat in a copulation-test cage, by allowing the male a few antecedent intromissions, or by allowing an antecedent ejaculation. The display of penile reflexes within 1 min after ejaculation suggests that the period of reduced sexual arousability following ejaculation is not due to reduced excitability in the spinal mechanisms controlling penile reflexes. In Experiment 4, 1 hr of penile-reflex elicitation had no effect on subsequent copulatory behavior. Thus, sexual stimulation may increase or decrease penile-reflex potential, but a reciprocal influence was not detectable.


Extent of recovery of function after early sensory deprivation in the rat. In two experiments the performances of 90- and 150-day-old light-reared and dark-reared rats were compared on rigorous tests of depth and form discriminative abilities. Significant differences due to rearing and age were found. Exposure to a normal light environment for 60 days was found to partially alter the effects of an early 90-day period of visual deprivation in the case of depth discrimination but to have little impact in the case of form discrimination. The implications of the results are discussed with regard to the proposition that the initial deficits in the performance of the dark-reared rats and the extent of recovery of function after exposure to a normal environment are related to the kind of perceptual ability being measured and to the sensitivity of the test.


Purification and characterization of rat alpha-lactalbumins: apparent genetic variants. Rat alpha-lactalbumin, from the milk of Fischer 344 (CDF) rats, was isolated and purified by a combination of gel filtration and diethylaminoethyl-cellulose ion exchange chromatography. Three electrophoretically distinct proteins had alpha-lactalbumin activity. Staining for carbohydrate indicated that at least two of the three forms were glycoproteins. The low molecular weight protein fraction from the wheys of two additional strains of laboratory rat were compared to ascertain whether the composition of this fraction was common in the divergent strains. Outbred Wistar and Long-Evans dams yielded wheys containing up to six forms of alpha-lactalbumin. Either one or both of two groups of three alpha-lactalbumins were in a given milk sample. The two groups of three alpha-lactalbumins appear to represent two genetic variants upon which is imposed a polymorphic character. All forms of alpha-lactalbumin, within and between strains, were immunologically identical.


Purification and partial characterization of a unique group of phosphoproteins from rat milk whey. A group of four electrophoretically distinct but related proteins has been isolated from rat milk whey. These have been classified as P.1 to P.4 in order of their decreasing electrophoretic mobility in an alkaline buffer system. All four members of this group of proteins are immunologically identical apparently constitute a single protein which is differentially phosphorylated in the ratio of 3:2:1:0. Sodium dodecyl sulfate gel electrophoresis yielded constant estimates of molecular weight of approximately 20,700. Enzymatic dephosphorylation of purified P.1 generated the other three members of the group, demonstrating the commonality of the peptide component. This group of proteins in total makes a significant contribution of the total whey proteins being approximately 5 mg/ml in whole rat milk in the approximate proportion of 1:1.5:2:1.5. The P.1, P.2, and P.3 were isolated in sufficient quantities to permit further characterization. The partial amino acid analyses of each of the three forms were similar. They had commonextinction coefficients, E1(1)% cm A280, of 4.9 and A280/A290 ratio of about 1.36.


Secretion of casein in cultures of mouse mammary epithelial cells on floating collagen gels. To study the effect of hormones on the secretion of casein, mammary epithelial cells were obtained from mid-pregnant mice and cultured on floating collagen gels in the presence of combinations of insulin, cortisol, and prolactin in serum-free culture medium. After labeling with phosphorus-32 labeled orthophosphate, the cells which had been cultured in the presence of all three hormones secreted hot-trichloroacetic acid precipitable radioactivity into the medium. The secreted materials were identified as three major mouse caseins by sodium dodecyl sulphate-urea polyacrylamide gel electrophoresis followed by autoradiography. The floating collagen gel culture method allows mouse mammary epithelial cells to differentiate and secrete all species of caseins in the presence of hormones. The present culture method and the phosphorus-32 labeling method will be applicable to the study of differentiation of mammary epithelial cells from a variety of mammalian species.


Relationship between milk yield and mammary gland development in mice. Female mice from four lines exhibiting different nursing ability (as measured by mean 12-day weight of eight offspring within a nursed litter) were used to examine milk yield, body size, feed intake, and cellular development of mammary glands and liver. Three selected lines exceeded the control line in milk yield and mammary gland and liver weights. They had more total deoxyribonucleic acid, ribonucleic acid, and protein contents in both mammary gland and liver tissues than the control. Phenotypic correlations between milk yield and deoxyribonucleic acid contents of mammary glands and liver were .39 and .35, while correlations between milk yield and protein to deoxyribonucleic acid ratio of mammary glands and livers were .04 and .11. Milk yield was correlated closely with body size .57 and with feed intake .55. Milk yield was related more to cell number than to cell size of the mammary glands and liver, and large amounts of milk were produced by heavy dams with substantial feed intake.


Potassium requirement of dairy cows in early and midlactation. Two trials with lactating Holstein cows were to determine the percent potassium required in the ration. A midlactation study compared three potassium percentages (.46, .69, and .97% of dry matter) for five cows assigned to each treatment for a 10-wk experimental period. In an early lactation study, 15 cows were assigned at 2 wk postpartum to one of three treatments (.51, .75, and .99%) for an 8-wk experimental period. Feed intake was changed by treatment from a control period (all cows fed the high K ration) +1.3, -.3, and +.1 kg for the .46, .69, and .97 treatments and +3.4, +1.0, and +.5 kg for the .51, .75, and .99 treatments. Milk production and change in body weight differed significantly in the first trial but not in the second trial. Blood serum potassium was significantly different due to treatment in the second trial with changes in percent potassium of -.6, -.4 and +1.1 for the three treatments. A potassium content of .7% appears to be adequate for cows in mid to late lactation; however, the feed intake and potassium in serum indicate that .7% may not be optimal for high producing cows in early lactation.


Milk iodine as influenced by an iodophor teat dip. We quantitated the increase of iodine in milk from iodophor teat dips and determined the mode by which that iodine entered the milk. In one trial with teat dipping for 1 wk, iodine in milk increased 8.8 microgram/100 ml. In another trial, only right udder halves were dipped with the iodophor. Samples of milk from the left udder half increased in iodine corresponding to the right udder half only slightly less. Tincture of iodine was applied to the skin between the vulva and the point of udder attachment of cows. Samples of milk from the group with tincture increased markedly in iodine content over the control group. Iodophor teat dips increased the iodine in milk by 8 to 10 microgram/100 ml. The primary mode of increased iodine appears to be absorption through the skin and entry into the milk by the milk synthesis process rather than by contamination from the teat's surface.


Radiotherapy of cutaneous cancers and some other malignancies. The principles of radiotherapy for the common cutaneous carcinomas of the skin are discussed and results illustrated. Shorter accounts of X-ray therapy of other, less common malignancies are also presented.


Efficacy, simplicity, and safety of X-ray therapy of basal-cell carcinomas on periocular skin. X-ray therapy of basal-cell carcinomas of periocular skin is highly successful, easy to carry out, safe, and attended by cosmetic results that are good to excellent.


Teleroentgen therapy for mycosis fungoides. Different techniques of teleroentgen therapy with soft X rays for total body treatment of cutaneous lymphomas are described. Therapeutic results in 26 patients with mycosis fungoides are reported.


Radiotherapy of mycosis fungoides: twenty years of experience with teleroentgen and low-voltage X-ray therapy. Of 98 patients with mycosis fungoides, 55 have been treated with teleroentgen therapy and 43 with low voltage radiation at a shorter distance. Teleroentgen therapy is indicated in the stage of generalized eczematous lesions or superficial infiltration. According to the Hamburg method, a dose of 300 R was delivered to eight fields at a target distance of 120 cm. After a series of one to three treatments, 300 R, administered at three-week intervals, all lesions usually cleared. Small patches and deeply infiltrated lesions and tumors were treated with the same doses and intervals of low voltage X rays, the half-value depth corresponding to the depth of infiltration. After five years, 54% of all patients were still alive and after 10 years, 29% were still living.


The worth of radiotherapy in malignant melanomas. A new approach for the evaluation of the effectiveness of various forms of treatment of malignant melanomas is presented. Factors influencing the survival time from initiation of therapy until death were statistically analyzed in 548 patients who died from malignant melanoma. In slowly developing malignancies X-ray therapy was found to be superior to therapeutic methods.


Adverse effects of superficial X-ray therapy and recommendations for safe use in benign dermatoses. The danger of superficial radiotherapy for benign dermatoses has been exaggerated. It is safe if certain precautions are observed. The permissible life time maximum cumulative dose of conventional superficial X rays generated at 50 kV given to any area of skin is 1000 R, and of grenz rays, 5000 R.


Radiation therapy for plantar warts.

Radiation therapy for plantar warts. Follow-up examinations were done on 598 plantar wart sites treated by radiation 3 to 28 years earlier. In 45 cases, minor skin changes were detectable. There were no frank radiation sequelae. Of three X-ray schedules used, a one-dose method is recommended because of its simplicity, efficacy and safety.


Cardiovascular nuclear medicine and intensive care. The clinical application of cardiovascular nuclear imaging techniques to intensive care medicine holds great promise for improved non-invasive assessment of the patient. With the development of new radiopharmaceutical agents and better instrument resolution, it is now possible to provide quantitative information concerning myocardial perfusion, acute myocardial ischaemia, left ventricular function, thromboembolic pulmonary disease and analysis of the patient's respiratory function. The patient can be studied during various phases of his disease, with these techniques furnishing objective guidelines of the therapy and prognosis.


Left ventricular function in tetanus: influence of therapy. Nine patients hospitalized for tetanus were studied under the same protocol which included two haemodynamic studies with a preload trial (PLT). The first being made during therapy (diazepam barbiturate association), on the sixth day of hospitalisation, and the second one after recovery. The comparison of the results shows that before PLT the mean arterial pressuure (MAP) is significantly increased (p less than 0.05) in patients after recovery in comparison to the same patients undergoing therapy. After PLT there is no significant difference between the two groups. Lastly, the variation of the left ventricular function points under PLT shows no significant difference between patients during therapy and after recovery. These results suggest that the diazepamphenobarbital combination does not alter the left ventricular function of the patients undergoing this therapy during tetanus.


Haemodynamic study of patients with severe sepsis during haemodialysis. A study was performed in order to observe haemodynamic changes induced by haemodialysis in 14 patients with acute renal failure and severe sepsis. Left ventricular function, as assessed by changes in pulmonary wedge pressure and left ventricular stroke work index through plasma volume expansion, did not change during haemodialysis. Ultrafiltration-induced decreases in cardiac index provoked in 8 patients, with nearly normal initial systemic arteriolar resistance, had adequate and constant increase in their resistance (p less than 0.001), whereas 6 patients with low initial systemic arteriolar resistance did not increase their resistance and had a frequent (9/13 measurements) and significant (p less than 0.001) fall in mean aortic pressure. This abnormality of vascular tone is probably due to severe sepsis and explains why hypotension is a frequent occurrence during haemodialysis in such patients.


The effects of insulin glucose administration in fulminant hepatic failure. Insulin glucose therapy can correct hyponatraemia and renal sodium retention in burns, sepsis and circulatory failure. A case of fulminant hepatic failure (F.H.F.) is described in which the same effect was observed. Insulin was thought to have corrected abnormal cell membrane permeability. The actions of insulin are discussed in relation to its possible role in the management of F.H.F.


Movement of the critically ill within hospital. Critically ill patients can be safely moved within hospital using a mobile intensive care unit (MICU). The MICU allows the critically ill to benefit from specialised investigation and treatment they might otherwise be denied. The MICU in use at the Western Infirmary, Glasgow is described and its merits outline in the light of clinical experience gained over a twelve month period.


Do fat emulsions protect against infusion thrombophlebitis? An experimental study. The clinical experience that a fat emulsion (Intralipid) protects the vein against infusion thrombophlebitis caused by an amino acid solution (Aminosol) was controlled by an experimental method based on a quantitative histological analysis of the inflammatory changes observed in the veins of rabbit ears after infusions. In a controlled blind study, sequential analysis failed to reveal any difference in the histological changes which developed after infusion of Aminosol alone and Aminosol plus Intralipid. In a second series of experiments in which Intralipid was compared with 0.9% NaCl it was demonstrated that the fat emulsion alone gave rise to considerable inflammatory changes in the veins.


Hypovolaemic shock with oedema due to increased capillary permeability. A case of severe hypovolaemic shock related to idiopathic oedema was observed in a 37 year old woman. Large plasma volume expansion (nearly 12 1 over 9 hours) did not change the clinical status. Haemodynamic studies showed low cardiac index (1.1 1/min/m2), decreased left ventricular stroke work index (6.7 gm/m2), and high systemic arterial resistance (52 mmHg/1/min/m2). Dopamine infusion improved the haemodynamic condition which returned to normal 30 hours after the beginning of shock. After recovery, capillary permeability measured by a modification of Landis' method was markedly increased. A study of albumin metabolism showed a normal intravascular pool and a rapid exchange compartment with a twofold increase in slow exchange compartment. Hormonal levels and complement fractions were within normal limits. Serum protein immuno-electrophoresis showed an abnormal IgG. These results clearly demonstrate that hypovolaemia is related to increased capillary permeability and leakage of albumin out of the vascular space. When large infusions fail, inotropic agents, especially Dopamine, should be used in such cases.


Modeling of the cat eardrum as a thin shell using the finite-element method. A finite-element model of the cat eardrum is presented which includes the effects of the three-dimensional curved conical shape of the drum. The model is valid at low frequencies (below 1-2 kHz) and within the range of linear vibration amplitudes. The material properties used are based on a review of the literature. The critical material parameters are the stiffness (2 times 10(8) dyn cm(-2)) and thickness (40 micrometer) of the pars tensa. The model exhibits a vibration pattern and amplitude very similar to those observed experimentally using laser holography. A number of parameters are varied in order to study their relative importance in the model.


Acute pulmonary oedema in a patient with phaeochromocytoma. A young patient with a phaeochromocytoma who presented as an acute non cardiogenic pulmonary oedema is described. Phaeochromocytoma should be considered as a possible cause of the "adult respiratory distress syndrome."


Method for computing motion in a two-dimensional cochlear model. We describe an effective technique for computing the steady-state motion in a two-dimensional cochlear model. With the cochlear fluid assumed incompressible and inviscid, the problem reduces to solving Laplace's equation for a region with a yielding boundary (corresponding to the basilar membrane). From an integral equation representation of this solution, a pair of second-order differential equations is derived. The solution of these differential equations gives the velocity of the basilar membrane and hence other related quantities, e.g., displacement, pressure, driving-point impedance at the stapes. Higher-order approximations, as well as extensions to nonlinear membranes are discussed.


Revised estimate of minimum audible pressure: where is the "missing 6 dB"? Eardrum pressures at hearing threshold have been calculated from both earphone data (ISO R389-1964 and ANSI S3.6-1969) and free-field data (ISO R226-1961). When head diffraction, external-ear resonance, and an apparent flaw in ISO R226 are accounted for in the free-field data, and real-ear versus coupler differences and physiological noise are accounted for in the earphone data, the agreement between the two derivations is good. At the audiometric frequencies of 125, 250, 500, 1000, 2000, 4000, and 8000 Hz, the estimated eardrum pressures at absolute threshold are 30, 19, 12, 9, 15, 13, and 14 dB SPL, respectively. Except for the effects of physiological noise at low frequencies, no evidence of the "missing 6 dB" is seen, an observation consistent with the experimental results of several recent studies.


Simultaneous pure-tone masking: the dependence of masking asymmetries on intensity. Phase locking between probe and masker was used in a series of pure-tone masking experiments. The masker was a stationary sine wave of variable frequency; the probe a fixed-frequency tone burst. We have observed that for small frequency separation the masking behaves asymmetrically around the probe frequency. This asymmetry depends on intensity. For a 1-kHz probe at low stimulus levels there is a maximum masking effect at about 60 Hz above the probe frequency, whereas at high levels maximum masking is produced at a frequency definitely below the probe frequency. These results are discussed in relation to current neurophysiological and psychophysical data. For the high-level assymetry possible interpretations are suggested in terms of two changes in the excitation pattern of the basilar membrane, (a) a shift of the top and/or (b) a slope asymmetry, both increasing with level. The low-level asymmetry will be treated in a second paper [Vogten, J. Acoust. Soc. Am. 63, 1521-1528 (1978)].


Perception of speech sounds with alternate formants presented to opposite ears. The perception of speech syllables with alternate formants presented to opposite ears has been investigated. Using synthesized speech and normal-hearing subjects, it was found that this mode of presentation reduced the recognition scores with stop consonants by about 6%, semivowels by about 4%, and fricatives by about 5%, compared with binaural presentation. Vowel recognition, on the other hand, was not significantly reduced.


Inversion of articulatory-to-acoustic transformation in the vocal tract by a computer-sorting technique. We present numerical methods for studying the relationship between the shape of the vocal tract and its acoustic output. For a stationary vocal tract, the articulatory-acoustic relationship can be represented as a multidimensional function of a multidimensional argument: y=f(x), where x, y are vectors describing the vocal-tract shape and the resulting acoustic output, respectively. Assuming that y may be computed for any x, we develop a procedure for inverting f(x). Inversion by computer sorting consists of computing y for many values of x and sorting the resulting (y,x) pairs into a convenient order according to y; x for a given y is then obtained by looking up y in the sorted data. Application of this method for determining parameters of an articulatory model corresponding to a given set of formant frequencies is presented. A method is also described for finding articulatory regions (fibers) which map into a single point in the acoustic space. The local nature of f(x) is determined by linearization in a small neighborhood. Larger regions are explored by extending the linear neighborhoods in small steps. This method was applied for the study of compensatory articulation. Sounds produced by various articulations along a fiber were synthesized and were compared by informal listening tests. These tests show that, in many cases of interest, a given sound could be produced by many different vocal-tract shapes.


Range effect in the perception of voicing. The location of the voicing boundary in the perception of initial stop consonants is shown to vary according to the range of voice-onset times used in a block of trials and according to the order in which blocks covering different ranges are presented. Although these range effects introduce methodological complications into the interpretation of adaptation experiments, they appear to be qualitatively different from adaptation effects and, it is suggested, may provide a metric for assessing the auditory tolerance of phonological categories.


Computer model to characterize the air volume displaced by the vibrating vocal cords. We use a vocal-cord/vocal-tract model devised earlier to study acoustic effects of the air volume displaced by the vibrating vocal cords. We consider both lateral and longitudinal motion of the cords. We make computer simulations to establish quantitatively the contribution of the displacement current to the total glottal volume velocity (and hence to the total sound excitation for voiced sounds). The displacement current from both lateral and longitudinal motion is found to be second-order by comparison to the total glottal flow. The displacement contribution can, however, be identified in the time waveforms and spectra of the glottal and mouth volume velocities. We use the computer formulation to synthesize speech sounds with and without the displacement current. Auditory observations and spectral calculations on the synthetic output show the displacement current to be discriminable only in close differential comparisons.


Acoustical properties of the human skull. The acoustical properties insertion loss, reflection loss, and sound speed were measured on a series of fresh and subsequently formalin immersed human skulls. Measurements were made in the frequency range from 0.25 to 6 MHz. Most studies were restricted to an upper frequency limit of 2.2 MHz. An axisymmetric focused beam configuration was used as the sound source for the measurements and the receivers were small disk-type (3-mm-diam) piezoelectric ceramics. The geometric and temporal character of the focused beam was studied as a consequence of passage through the skull sections. Some skulls were sectioned so that their individual layer components could be studied. A simple three-layer analytical model seems to explain the major aspects of insertion and reflection loss. The dominant feature in determining human adult skull losses is the middle layer (diploe) of cancellous bone. This study corroborates previous work on insertion loss as a function of frequency for composite skull. The study provides new quantitative information on the acoustic scattering properties of diploe, sound velocity, and dispersion in composite skull and its components, attenuation coefficients in skull components and sound-beam distortion and shifts after transmission through composite skull. We conclude that with selection of appropriate frequencies (0.5-1.0 MHz) and beam configuration it will be possible to perform clinically significant transkull diagnostic imaging and interrogation in the adult human brain.


Auditory duration discrimination in the parakeet (Melopsittacus undulatus). Two parakeets were trained by a method of avoidance conditioning to respond to duration differences in successively occurring tone bursts. Difference limens for duration were obtained at six durations (20-160 ms) of a 2.86-kHz tone presented at a sensation level of 60 dB. Calculations of the Weber fractions at each duration showed threshold values which compare favorably to similar measures for man ranging between 0.10 and 0.20.


Gonioscopy using the Brandreth-Saladin goniochamber. The Brandreth-Saladin Goniochamber is a new diagnostic instrument available to the optometric profession. In this paper, a description of the instrument and technique is given and the results obtainable with the Goniochamber are compared to those obtainable with existing gonioscopic instruments.


Hollenhorst plaques--II.

Hollenhorst plaques--II. Detection of Hollenhorst plaques in the retinal circulation of the asymptomatic patient should be considered to be indicative of atherosclerotic disease. Such patients should be referred for medical evaluation and amelioration of risk factors.


Identification of the patient at risk: an optometric role in the prevention of stroke. Identification of patients at risk for stroke and institution of medical management to reduce risk are the essentials of preventing stroke. Optometrists can play a role in the prevention by identifying patients at risk and directing them to appropriate medical care. The paper reviews the pathogenesis and clinical presentation of thrombotic, embolic and hemorrhagic stroke. The profile of potential victims is outlined with emphasis upon risk factors which may present in optometric patients; hyperlipidemia, hypertension, smoking, unruptured aneurysm, retinal emboli, and transient ischemic attacks.