Morphometric analysis of the translocation of lumenal membrane between cytoplasm and cell surface of transitional epithelial cells during the expansion-contraction cycles of mammalian urinary bladder. The flow of membrane between the cytoplasm and the lumenal surface during the expansion-contraction cycle of urinary bladder was estimated by stereological examination of electron micrographs of urothelial cells from guinea pigs, gerbils, hamsters, rabbits, and rats. The quantitative data obtained allowed an approximation of the surface area, volume, and numbers of lumenal membranelike vesicles and infoldings per unit volume of cytoplasm. Depending upon the species, approximately 85 to approximately 94% of the membrane surface area translocated into and out of the cytoplasm was in the form of discoidal vesicles. The remainder was accounted for by infoldings of the lumenal plasma membrane. The density of vesicles involved in transfer of membrane was quite similar in all the species examined, except guinea pigs which yielded lower values. In contrast, the densities of the total cytoplasmic pools of discoidal vesicles potentially available for translocation varied greatly among the different species. In general, species of animals with a highly concentrated urine had a greater density of discoidal vesicles than species with a less concentrated urine. This correlation may indicate an authentic relationship between lumenal membranes and the tonicity of urine, such as increased membrane recycling or turnover with increasingly hypertonic urine; or it may signify the existence of some other, more obscure relationship.


Mitosis in Barbulanympha. II. Dynamics of a two-stage anaphase, nuclear morphogenesis, and cytokinesis. Anaphase in Barbulanympha proceeds in two discrete steps. In anaphase-A, chromosomal spindle fibers shorten and chromosomes move to the stationary centrosomes. In anaphase-B, the central spindle elongates and ("telophasic") bouquets of chromosomes, with kinetochores still connected by the shortened chromosomal fibers to the centrosomes, are moved far apart. The length, width, and birefringence of the central spindle remain unchanged throughout anaphase-A. In anaphase-B, the central spindle elongates up to fivefold. During elongation, the peripheral fibers of the central spindle splay, first anteriorly and then laterally. The remaining central spindle progressively becomes thinner and the retardation decreases; however, the coefficient of birefringence stays approximately constant. The nuclear envelope persists throughout mitosis in Barbulanympha and the nucleus undergoes an intricate morphological change. In prophase, the nucleus engulfs the spindle; in early anaphase-A, the nuclear envelope forms a seam anterior to the spindle, the nucleus thus transforms into a complete sleeve surrounding the central spindle. In late anaphase-A, the middle of the seam opens up in a cleft as the lips part; in anaphase-B, the cleft expands posteriorly, progressively exposing the central spindle. Finally, the cleft partitions the nucleus into two. The nuclear envelope shows an apparent elasticity and two-dimensional fluidity. Localized, transient deformations of the nuclear envelope indicate poleward and counter-poleward forces acting on the kinetochores embedded in the envelope. These forces appear responsible for nuclear morphogenesis as well as anaphase chromosome movement. At the end of anaphase-B, the two rostrate Barbulanympha may swim apart of be poked apart into two daughter cells by another organism cohabiting the host's hindgut.


Differences between nucleus and cytoplasm in the degree of actin polymerization. For purposes of studying the degree of polymerization of actin in nuclei, nuclei from 35S-labeled amoebas (Amoeba proteus) were transplanted into unlabeled cells, which were immediately lysed and extracted under conditions considered to stabilize preexisting fibrous actin. The enucleated 35S-donor cells were similarly treated for analysis of cytoplasmic actin. The extraction conditions permitted separation of soluble (unpolymerized or G) actin from pelletable (polymerized or F) actin, and the radioactivity of each was determined after the actin was separated from other proteins by polyacrylamide gel electrophoresis. We found that about 2/3 of the actin within the nucleus is pelletable, whereas only about 1/3 of the cytoplasmic actin is pelletable. We speculate that polymerized actin in the nucleus is involved in the condensation of chromatin.


Prosthetic valve endocarditis after heart catheterization. It is accepted that patients with valvular disease or valvular prosthesis should be protected against endocarditis during procedures causing bacteriemia. On the other hand it has been shown that bacteriemia occurs during catheterization. Thus, protection against endocarditis for patients undergoing catheterization deserves more consideration, specially among patients with prosthetic valves. Moved by the fatal outcome of one of our patients with postcatheterization prosthetic valve endocarditis, the authors leave an open discussion about this subject.


Acute bacterial endocarditis following traumatic ventricular septal defect. Traumatic ventricular septal defect occur rarely although penetrating wounds of the heart rate are fairly common. The urgency for the surgical correction of traumatic ventricular septal defects has been debated. In life-saving instances where left heart failure or cardiac tamponade occur, the decision is simple. A case report of early bacterial endocarditis complicating traumatic ventricular septal defect in the first 12 hours following injury has been presented. Avoidance of this complication by early surgical correction is advocated.


Localization of the guinea pig eosinophil major basic protein to the core of the granule. The localization of the guinea pig eosinophil major basic protein (MBP) within the cell was investigated by the use of immunoelectron microscopy and by isolation of the granule crystalloids. First, by immunoperoxidase electron microscopy, we found that the MBP of eosinophil granules is contained within the crystalloid core of the granule. Specific staining of cores was present when rabbit antiserum to MBP was used as the first stage antibody in a double antibody staining procedure, whereas staining was not seen when normal rabbit serum was used as the first stage antibody. Second, crystalloids were isolated from eosinophil granules by disruption in 0.1% Triton X-100 and centrifugation through a cushion of 50% sucrose. Highly purified core preparations yielded essentially a single band when analyzed by electrophoresis on polyacrylamide gels containing 1% sodium dodecyl sulfate (SDS). The E1%1cm of the core protein was 26.8 +/- 1.0 (X +/- SEM); the E1%1cm for the MBP was 26.3. The core protein could not be distinguished from the MBP by radioimmunoassay (RIA) and essentially all of the protein in the core preparations could be accounted for as MBP. The results indicate that the MBP is contained in the core of the guinea pig eosinophil granule and that it is probably the only protein present in the core.


"The Merck Index": the merits of using computers in publishing. "The Merck Index", an internationally recognized encyclopedia of drugs, chemicals, and biologicals was produced by the traditional method for eight consecutive editions. Owing to the rapidly increasing volume of information and escalating costs of book production, it became desirable to design a computer-assisted production method for preparation of the recently published ninth edition. The method that was developed and used as well as the philosophy behind its use are described.


Biochemical and stereological analysis of rat liver mitochondria in different thyroid states. The concentrations of the inner mitochondrial membrane markers cardiolipin and cytochrome alpha have been measured in liver homogenates and in purified mitochondria after thyroxine administration to thyroidectomized and normal rats. The biochemical results have been correlated with stereological electron micrographic analyses of hepatocytes in liver sections, and of isolated mitochondrial pellets. There were progressive and parallel increases in homogenate and mitochondrial cardiolipin concentration, and in mitochondrial cytochrome alpha concentration, after administration of 20 microgram of thyroxine on alternate days to thyroidectomized rats, and of 300 microgram on alternate days to normal rats. Electron microscope measurements showed marked differences in the shape of the mitochondria and in the number of cristae in different thyroid states. Hypothyroid mitochondria were shorter and wider than controls, and hyperthyroid mitochondria longer but of similar width. Mitochondrial volume per unit cell volume was virtually unchanged in hypo- and hyperthyroid animals. The most striking changes were a decrease in the area of the inner membrane plus cristae in thyroidectomized rats, and a substantial increase in membrane area after thyroxine administration. The biochemical and electron micrographic results indicate that, in rat liver, thyroid hormone administration leads to a selective increase in the relative amount of mitochondrial inner membranes, with little or no change in the mitochondrial volume per unit cell volume, or in total mitochondrial protein per unit total cell protein.


Analysis of the registry of toxic effects of chemical substances (RTECS) files and conversion of the data in these files for input to the environmental chemicals data and information network (ECDIN). A data bank for environmental chemicals, ECDIN, is being developed at the Joint Research Centre of the European Communities in cooperation with universities and research institutes in the nine member states as a part of the Environmental Research Programme of the EC. During the pilot phase of the project, data from the Registry of Toxic Effects of Chemical Substances have been incorporated into the data bank. Conversions of the data into ECDIN input format was necessary before inclusion of the toxicity data in ECDIN, and the computer programs used for this format conversion have produced various statistics for the contents of the RTECS files. Analyses of the data in three editions of RTECS are presented.


[Anaerobic bacteria in digestive surgery. Pathogenic role and prognostic incidence (author's transl)]. The authors isolated in common surgical practice 83 anaerobic bacteria mainly bacteroides and clostridia. They analyse their pathogenic role in relation to the site of sampling. Comparing the bacteriological results with a clinical study of 96 cases of generalised peritonitis, there appeared to be no significant differente between the prognosis in peritonitis and anaerobic bacteria and those without anaerobic bacteria. The mortality was identical in septicemia due to anaerobic and aerobic bacteria; jaundice was just as frequent in both series. However, the prognosis of peritonitis due to anaerobic bacteria seems better when antibiotic treatment is adapted to the bacteria, e.g. lincomycin, metronidazole. With regard to anaerobic bacteria, which represent only part of the fecal flora, it may be dangerous by selection of resistant strains to use prophylactic antibiotics as a routine; local treatment of the septic focus seems the most important. The pathogenic role of anaerobic bacteria in digestive pathology is far from clearly defined; one should not follow the fashion of using even specific antibiotics without justification.


[Aseptic inflammatory reaction in surgery of the knee (author's transl)]. The author reports 15 cases which show the clinical and laboratory characteristics and treatment of the aseptic inflammatory reaction observed after operation on the knee. It should be carefully distinguished from pyogenic arthritis; the clinical signs and the appearance of the synovial fluid are identical. Only laboratory examination permits ones to distinguish them, by the presence or absence of bacteria. This is a benign complication which becomes cured within a few days by common medical anti-inflammatory treatment. The danger is confusion with septic arthritis and the choice of inappropriate treatment, which often causes severe sequelae of even secondary infection. The true cause of this complication which in every way resembles acute inflammatory rheumatism, remains unknown.


[Dislocations of the calcaneum, talus and navicular bones. Report of 7 cases (author's transl)]. The authors report 7 cases of sub-taloid dislocation, to which they prefer Allieu's term of talo-navicular-calcaneal dislocation, either internal (the most frequent) or external (rare) depending on the direction of displacement of the foot. After studying their mechanism, they analyse the results, which, contrary to dislocation-fractures of the talus, are usually good, in spite of the frequency of subtalal arthritis.


[An isolated neurinoma in the pancreas (author's transl)]. The authors report the clinical record of an isolated neurinoma in the pancreas of a fifty year old African woman. Thanks to this observation and ten other cases previously described by literature, they remind of the rarity of this localization as of the polymorphous clinical aspects in this disease. They point out the difficulty of anerting the positive diagnostic as well as the importance of the histological investigation which alone can authenticate the lesion and precise its benign ou malignant nature.


[Contribution to the study of gallstones. Morphological, radiological and cristallographic analysis (author's transl)]. The structure of gallstones has become of recent interest with the medical treatment of cholesterol stones. It seemed to us interesting to determine by morphological, radiological and above all cristallographic criteria the constituants of gallstones in order to draw up a practical classification which reflects better the biological reality. The present study confirms the existence of cholesterol and calcium carbonate in various types of stone, but reveals in addition the presence of cholesterol and bile salts associated with new mineral constituants identified for the first time (aluminium chlorite and silicate). The notion of pure stones, generally attributed to cholesterol and pigmented stones was only verified in the case of mineral stones.


Thin-layer detection of diazepam and/or chilordiazepoxide alone or in combination with major drugs of abuse in drug abuse urine screening programs. Three extraction procedures for the detection of diazepam, oxazepam, chlorazepate and/or chlordiazepoxide in human urines are presented. All three procedures are based on the acid hydrolysis of benzodiazepines and/or their conjugated metabolites to give the corresponding benzophenones. Procedure I involves the direct acid hydrolysis of raw urine and is recommended when the aim is to test the abuse of benzodiazepine derivatives only. Procedure II Is a two-step extraction method in which a wide variety of drugs of abuse including cocaine (test based on the detection of benzoylecgonine) are extracted by the first step using paper loaded with cation-exchange resin and the benzodiazepines are tested in the second step by the acid hydrolysis of the spent urine left after removing the ion-exchange paper. Procedure III involves the use of inert fibrous matrix and then its acid hydrolysis. The detection procedure is based on the identification of methylaminochlorobenzophenone (MACB) and aminochlorobenzophenone (ACB). MACB is detected as a yellow-colored compound while ACB is detected by spraying with Bratton-Marshall reagent. Specificity of detection of ACB has been achieved by the selection of a thin-layer developing solvent system in which sulfonamides with primary aromatic amino groups remain at the origin.


An improved method for determining total urinary phenol. A simple and easily manipulated method is described for th- determination of total urinary phenol. This modification of earlier procedures incorporates the enzymatic hydrolysis of conjugated phenol, extraction of the hydrolysis products into isopropyl ether and final quantitation by gas-liquid chromatography-flame ionization detection. The method employs benzyl alcohol as internal standard.


Combined high-pressure liquid chromatography and radioimmunoassay method for the quantitation of delta 9-tetrahydrocannabinol and some of its metabolites in human plasma. A high-pressure liquid chromatography-radioimmunoassay (HPLC-RIA) method for the measurement of cannabinoid levels in plasma is described. The method is capable of quantifying 0.1 ng of a cannabinoid in 1 ml of plasma. The experimental procedure consists of an initial separation of cannabinoids in a plasma extract by HPLC followed by collection of the HPLC eluate and RIA. A chromatogram consisting of the cross-reacting cannabinoids in plasma may then be constructed. The plasma concentrations of cannabinoids with retention volumes equivalent to those of delta 9-tetrahydrocannabinol, cannabinol and mono-hydroxylated metabolites have been measured by this technique.


[Determination of ketoprofen in plasma using high-performance liquid chromatography. Comparison with gas--liquid chromatography (author's transl)]. A new method of determination of ketoprofen 2-(3-benzoyl phenyl) propionic acid in plasma using high-performance liquid chromatography (HPLC) is described. After extraction by diethyl either in acidic medium, ketoprofen and the internal standard, 2-(4-benzoyl phenyl) butyric acid, are methylated with gaseous diazomethane and their concentrations measured by HPLC using in LiChrosorb Si 60 (5 micrometer) column and dichloromethane-hexane (60:40) as the mobile phase. The absolute retention times of the internal standard and ketoprofen are 11.6 and 12.8 min, respectively. The precision of the methods is +/- 4% and the lower detection limit ranges from 0.06 to 0.10 microgram/ml. The results obtained by HPLC show a very good correlation with those obtained by gas--liquid chromatography. The proposed method is sensitive, reproducible and rapid and very suitable for ketoprofen determination in pharmacokinetic studies.


[Detection of sulfamethoxazol and N4-acetylsulfamethoxazol in  biological fluids by resversed-phase high-pressure liquid chromatography (author's tarnsl)]. Sulfonamide drugs can be detected by reversed-phase hihg-pressure liquid chromatography. The possibilities of this method in the direct qualitative and quantitative analysis in blood or in urine without enrichment and derivatization are illustrated by the analysis of sulfamethoxazol and its metabolite N4-acetylsulfamethoxazol.


Improved separation of nucleosides, nucleotides, and aminoacyl tRNA a strong anion-exchange resin. Nucleosides and nucleotides can be separated on a polystyrene-dinylbenzene anion-exchange resin, Chromex DA-X8-11 at 50 degree using isocratic elution with 1.0 M ammonium carbonate pH 8.8 or 0.05 M formic acid pH 2.4. The resin can also resolve aminoacyl tRNA on either the analytical or preparative scale.


A novel and rapid method for the preparation of methyl esters for gas chromatography: application to the determination of the fatty acids of edible fats and oils. A rapid, mild, and convenient transesterification of triglycerides was obtained using 0.2 N-methanolic (m-trifluoro-methylphenyl) trimethylammonium hydroxide. The method yielded results comparable to those obtained using methanolic sodium methoxide.


Determination of aflatoxins in peanut products using reverse phase HPLC. A high performance liquid chromatographic (HPLC) method is described for the determination of the four major aflatoxins, B1, B2, G1 and G2, in peanut products. The aflatoxins are extracted by adapting a procedure developed by Pons (1) at the SRRC, USDA, and quantitated utilizing a new 5 mum reverse-phase column with NaCl/acetontrile/methanol mobile phase (3 + 1 + 1). The 5 mum column achieved baseline resolution of each of the four aflatoxins. Retention times and peak heights were reproducible. The procedure was successfully applied to several types of peanut products and was applicable to both roasted and unroasted peanuts, which is a decided advantage over the current CB and BF extraction methods. Additionally, it can be used for sweetened peanut matrixes with no interferences in the chromatography. The total time required for sample preparation and aflatoxin determination is less than 1.5 hours.


The Personal Health Survey.

The Personal Health Survey. The Personal Health Survey (PHS) is a 200-item inventory that consists of 12 scales of empirically constructed items that relate to symptomatology from the principal psychophysiological supporting systems. The PHS was administered to 730 Ss in five clinical groups. Base rates of responding T or F to each item were compared across the five diagnostic groups. The test results were factor analyzed with a principal component method combined with Varimax rotation. The factors were orthogonal. Five main factors were extracted from the overall population and from each of the five subgroups and compared as to item composition. Administration, scoring, interpretation and validation of the empirical and factored scales are discussed.


Factored scales for the Personal Health Survey with schizophrenics, alcoholics, felons, unmarried mothers, and college students. Employed the Personal Health Survey (PHS) to study patterns of symptomology related to physical and mental health in a population of 730 Ss, which consisted of five subgroups: felons, hospitalized alcoholics, unmarried mothers, college students and institutionalized schizophrenics. The factorial data were analyzed in terms of (a) size of item factor loadings; (b) base rates of responding True to each item; and (c) clinical judgments as to the specificity and meaning of the items and factor scale patterns. Five main factors were extracted: Factor I--General health status; Factor II--Sociopathic character disorders; Factor III--Mixed psychiatric symptoms; Factor IV--Anxiety state with psychosomatic symptoms and general nervousness; and Factor V--Schizophrenicity.


The factorial structure of the Personal Health Survey in normals and schizophrenics. Administered the Personal Health Survey to five different groups: 74 incarcerated felons, 47 hospitalized alcoholics, 172 unmarried mothers, 51 college students, and 386 hospitalized chronic schizophrenics. On 191 of 200 items, the schizophrenics had higher base rates than any other group. Although some groups did not have large enough Ns for statistically adequate factor analyses, factorial studies also were done on the four control groups. Every group studied gave different factor patterns, with different orders of emergence of factors, different item loadings and heterogeneous composition of items. It is concluded that subgroups should be factored independently across time to determine population characteristics because overall population patterns do not make possible more than general predictions about subgroups. Individuals cannot be predicted from either overall or subgroup factorial characteristics.


Methodological advances in the validation of inventory items, scales, profiles and interpretations. Factor analytic research is still in its infancy--theoretically, methodologically, and interpretively. Definitive research has not yet been done on problems of (a) item design and selection of items suitable for factor analysis; (b) identification of highly significant marker items; (c) tracings of item response distributions across scales, populations, occasions and other relevant variables; (d) determination of the number of items with different loadings necessary to obtain valid scale scores for psychological state measurements; (e) questions about the validity of summating factorially heterogeneous lowly correlated items in arriving at scale scores; (f) the use of clinical judgment to evaluate the possibly differing significances of the same item responses across populations and occasions; i.e., does the same factored item response have the same significance across scales?; (g) how to interpret scales with factorially mixed item compositions; (h) clinical judgement decisions in evaluating and interpreting scale meanings; and (i) the comparison of the results of analyzing data by different scaling methods. This study makes a start toward clarifying these methodological issues by analyzing the results of applying different methods of scale construction that utilized 146,000 item responses made by 730 Ss on the Personal Health Survey, a 200-item inventory designed to measure organ system functioning that contributes to physical and mental health.


Predictors of psychiatric illness among Navy hospital corpsmen. Evaluated Recruit Temperament Survey (RTS) responses and aptitude test scores as potential predictors of psychiatric illness among 1,082 Navy hospital corpsmen. Twenty-six RTS items discriminated significantly between those corpsmen who became psychiatric casualties during a 4-year criterion period and those who did not; these items appeared to assess a construct of preservice personal and vocational adjustment. Scores on the aptitude measure were unrelated to illness incidence. The validity of the discriminating RTS items taken in combination for predicting psychiatric hospitalization among corpsmen was .28 with a cross-validity of .22. Implications of these findings for the use of measures such as the RTS in psychiatric screening were discussed.


Sex differences in anxiety response and adjustment to dental surgery: effects of general vs. specific preoperative information. Monitored anxiety level by the State-Trait Anxiety Inventory and Corah's (1969a) dental anxiety scale and evaluated adjustment via behavioral ratings, in 32 female and 31 male dental surgery patients who were presented general or specific information prior to surgery. The findings indicated that dental surgery is a stressful procedure that elicits comparably high levels of state anxiety in males and females. For most patients, even those high in dental anxiety, state anxiety level returns to "normal" levels just after the completion of surgery. The dental anxiety scale administered well before surgery is a good predictor of patient anxiety level in the dental situation, especially for males. Females responded to an informational tape received prior to surgery with increased anxiety, and were rated as showing poorer overall adjustment in surgery than males. The general and specific information tapes did not differentially affect adjustment, but informational input and related variables such as patient expectancies and prior level of information are factors that need further investigation in terms of their potential relevance for the reduction of patient anxiety and enhancement of patient adjustment during dental procedures.


Social skills training for the complex offender: employment seeking skills. Compared 11 probationers with a history of psychiatric referral to a randomly selected group of unemployed persons from the State Unemployment Office in a number of job interview assessment situations. The probationers were rated as less skillful and also rated themselves as less likely to obtain employment than did the control Ss. After this pretest, the probationers were assigned to one of two treatment groups in which either monetary incentives for job interviews were provided or a skills training program was initiated. Posttest scores indicated that the skills program was most effective in changing behavioral and cognitive responses. These results generalized during the follow-up period; the skills training group obtained employment more frequently than did the incentive group. Implications for training critical skill deficits are discussed in terms of a response acquisition model.


Analysis of structural factors in schizophrenic delusions. A previous factor analysis of delusional properties, scored from verbatim typescripts of interviews held with 32 schizophrenic patients, had generated four interpretable factors. The present study considered the meaning of these qualitative factors in terms of their relationships to four types of information potentially important to understanding the development or maintenance of delusions--sex gender, intelligence, chronicity, and type of delusion (e.g., persecution, grandeur). The possible contribution of factorial structure to understanding delusional behavior was indicated by the number of relationships found between these factors and the independent variables.


MMPIs of rapists of adults, rapists of children, and non-rapist sex offenders. Compared MMPI group mean profiles of rapists of adults, rapists of children, and non-rapist sex offenders. All three groups showed similar elevations on scale 4, but they differed in the extent to which scale 8 characteristics combined with those of scale 4. Rapists of adults showed an elevated 8-4 profile, rapists of children showed a 4-8 profile but with scale 8 somewhat lower, and non-rapists showed a high-4 profile with scale 8 elevated still less. Though there was marked heterogeneity in the two-point codes within groups, still the group results supported the notion that while all three types of sex offenders are impulsive and self-centered with poor social intelligence, the rapists of adults are more hostile, resentful, and interpersonally alienated than are rapists of children, and both types of rapists show those hostile and resentful characteristics more than do non-rapist sex offenders.


The nature of deficit among paranoid and nonparanoid schizophrenics in the interpretation of sentences: an information processing approach. Compared paranoid and nonparanoid schizophrenics to normal controls on a sentence verification task. The task permitted separation of times taken for central scanning and comparison operations and for operations associated with response selection and response execution. Neither group of schizophrenics took more time than normal controls for the latter operations; however, both groups of schizophrenics took longer at central scanning and comparison. Performance on this task was compared to previous results in which schizophrenics were similar to normals on times for central scanning and comparison, but took longer for non-central aspects of processing. It was condluded that the present deficit at the central processing level was attributable to deficient short-term memory of the encoded version of the sentence during the scanning and comparison operations. The absence of differences in the time taken for the non-central operations was ascribed to the exclusion of sentence encoding from the present latency times.


Anxiety and classroom examination performance. Studied classroom examination performance over the course of an entire semester as a function of (a) students' anxiety level (high, medium, low); (b) difficulty level of exam question (more vs. less difficult); (c) type of exam question (rote memory vs. generalization); (d) sex of S; and (e) intelligence level of S. As expected, there was a strong main effect of anxiety and a significant interaction between anxiety and item difficulty. The latter was consistent with the Hull-Spence formulation of learning and performance--as the habit strength of incorrect responses increases (i.e., as the items become more difficult), the superiority of low over high anxious Ss also should increase. When item difficulty was held constant, anxiety did not interact with type of exam question.


Locus of control as a predictor variable in rehabilitation medicine. Reports the results of preliminary work with the Adult Nowicki-Strickland Internal-External Locus of Control Scale. It was predicted that treatment motivation and treatment success would be related to the dimension of locus of control. Independent physiotherapist's ratings confirmed the first hypothesis, but not the second. This appears to be a fruitful area for further research with this instrument.


An exploratory study of the interaction between personality and psychopathology. Presented an exploratory study that focused on the relationship between personality and psychopathology. A sample of 389 male veterans was evaluation and diagnostically categorized into four mental illness categories and one nonmental illness group. Each S was tested with the MMPI and the Differential Personality Questionnaire. Several analyses were performed to test two of Zubin's (1967) hypotheses about possible interactions between personality and psychopathology. Results are seen as suggestive that personality is neither independent nor interactive with psychopathology.


The relation between trait anxiety and the Harris MMPI PD subscales among psychiatric inpatients. Investigated the relationship between trait anxiety and MMPI PD scores among psychiatric inpatients from a multidimensional standpoint by means of the Harris PD subscales. The trait anxiety scale of the State-Trait Anxiety Inventory and the Harris PD subscales were administered to 24 female and 21 male psychiatric inpatients. Trait anxiety was correlated positively with the basic PD scale in accord with previous findings. However, the Self-Alienation and Social Alienation PD subscales were the only Harris subscales that were correlated significantly with anxiety in the positive direction. The Social Imperturbability PD subscale was related inversely to trait anxiety. The findings were discussed primarily in terms of the potential benefit of employing the Harris subscales in studies of psychopathy and in clinical settings.


Muscle tension and personality.

Muscle tension and personality. Studied the relationship between skeletal muscle activity and personality variables as measured by the MMPI in 17 male and 51 female patients (most with chronic pain) in a large general hospital. After administration of the MMPI, muscle activity was measured from the frontalis. A biserial correlation coefficient was calculated between muscle tension and each of 12 MMPI scales. The high-tension group obtained a significantly higher score on scale L and a significantly lower score on scale PD.


The separation of organics from depressives with ability- and personality-based tests. Previous research has indicated that ability-oriented organicity tests are of limited value in the separation of brain-damaged from schizophrenic patients in psychiatric hospitals. In the present study the capabilities of nine ability test measures and the MMPI Depression scale to differentiate organics from depressives were evaluated. Only six of the nine ts used to evaluate the differences between the two groups were significant at the 0.5 level and, after the samples were levelled for age, education and IQ, the number fell to zero. In contrast, the Depression scale differences were highly significant both before and after levelling. Multiple correlations run to evaluate the use of personality and ability measures in combination showed that they had considerable promise and suggest that the separation of organic from functional psychiatric hospital groups is best achieved by such combinations.


An MMPI sign to separate organic from functional psychiatric patients. Evaluated the utilities of all 90 possible unweighted additive/subtractive two-scale MMPI combinations as indices to separate brain-damaged from functional patient groups in a Veterans Administration psychiatric hospital. One index, Hs-PT, showed more promise than any of the other 89. Hs-PT mean scores were significantly higher among organics than among alcoholics, neurotics, affective psychoses, character disorders, process schizophrenics or reactive schizophrenics. Interpretative information on the Hs-PT index was presented.


Effects of participation in the Physical Conditioning Platoon. Designed to assess the effects of Marine recruits' participation in the Physical Conditioning Platoon during 1975 (N - 635). Comparisons (t-values) of pre and post measures of an attitude questionnaire, the Comrey Personality Scales, and a self-evaluation scale indicated that significant increases in favorability of perceptions occurred during training for 12 of the 13 scales. During a stay of approximately 30 days, overweight recruits lost an average of 26 pounds. The most powerful predictors of graduation from PCP and recruit training included the Affiliation (with the Marine Corps) scale and a composite of 10 Activity Scale items. These two variables may be useful in selection of PCP participants by reducing the 36% PCP attrition rate.


Foulds' "general instability" and "psychopathy" 16PF scales and their relationship to psychiatric mood state. Previous research examined "general instability" and "psychopathy" scales, derived from the 16PF, in terms of Foulds' criteria of content, group differentiation, change over time, and score distributions. When the external criterion of a newly validated measure of psychiatric mood state (the DSSI/sAD) was used, it was confirmed in both a patient and a normal group that the "general instability" scale is related significantly to symptomatology, while the "psychopathy" scale is relatively independent of present state.


Death fantasies and future time perspective. Explored death fantasies of young adults through use of life scripts and future time perspective questionnaires. Results indicated a significantly younger age of death from disease and accident as opposed to natural causes. Type of death fantasied was markedly at variance from health statistics, with most projecting a benign end for themselves (old age).


The use of grafted polynomials and dummy variables in analyzing time series data. Describes an innovative statistical method for analyzing single-S time series data. The S and data in the paper were selected from a larger study which applied operant conditioning to ambulation problems of severely handicapped patients and used positive verbal reinforcement. The method described is a variation of traditional multiple regression analysis described elsewhere as "grafted polynomials" (Draper & Smith, 1967; Fuller, Note 1). An extensive explanation of the use of dummy variables also is provided.


The Disruptive Behavior Scale: an objective assessment of unmanageable social behavior in adolescents. The Disruptive Behavior Scale, a 26-item behavioral checklist, provides an objective measure of socially unacceptable public secondary school behavior and may prove to be of value in determining public school exit and reentry plans for disruptive adolescents. The checklist may be completed in 15-25 minutes and does not require direct administration. Test-retest reliability scores were significant (p less than .05) for all items; item-whole test scores were significant for all but 2 items. Both initial and replication validity studies that involved comparisons between public school students and adolescents expelled from public schools yielded significant differences (p less than .05) in the expected direction.


Factors in the rotation of reproduced figures. Investigated the effectiveness of presenting some of the MPD designs on rotated backgrounds; examination was made of the incidence of a particular rotational error in the records of 246 psychiatric patients. This error, the reproduction of the square of the circle-square design in "square" instead of the correct "diamond" orientation, occurred very much more often when the background was rotated than when it was normal, which confirmed that the orientation of the background had a strong effect on the reproductions. The error was made significantly more often by Ss with brain damage than by those with functional disorders. The findings were discussed in relation to the concept of field-dependence.


Intellectual functioning in lobotomized and non-lobotomized long term chronic schizophrenic patients. Administered the WAIS routinely to 28 long term hospitalized chronic schizophrenic patients who had a bilateral prefrontal lobotomy during the years between 1948 and 1954 and 28 of their non-lobotomized counterparts matched on appropriate demographic characteristics. No statistically significant t-score differences between group means were demonstrated on any of the 11 subtests or three scale IQs.


Normative data for the Tactual Performance Test. Investigated the effects of age and IQ on the Tactual Performance Test (TPT) with 117 normal Ss divided into three IQ ranges (91-111, 112-122, 123-139) and four age ranges (20-29, 30-39, 40-49, 50-60). The high percentage of older Ss classified as brain-damaged by Reitan's suggested cut-off scores indicated the need for age adjusted cut-offs. A revised cut-off score for total time of 17.7 minutes for the 30-49 age range and 21.7 minutes for the 50-60 age range was suggested. A revised cut-off score for memory of 5 or less for the 20-39 age range, 4 or less for the 40-49 age range, and 3 or less for the 50-60 age range was suggested. A cut-off score for location of 3 or less for the 20-29 age range, 2 or less for the 30-49 age range, and 1 or less for the 50-60 age range was suggested. Examination of preferred and nonpreferred hand times on the TPT showed that either a simple difference or a ratio of the two scores could be used to establish normative scores unaffected by age or IQ.


Psychometrics of a neuropsychological test battery. Compared factor analysis (linear) and hierarchical cluster analysis (nonlinear) of a neuropsychological battery of tests, including the Wechsler Adult Intelligence Scale, the Wechsler Memory Scale, the Graham-Kendall Memory for Designs Test, and the Bender Visual Motor Gestalt Designs Test. The results were discussed within the framework of descriptive and predictive analysis of the major cognitive functions of verbal intelligence, perceptual performance, and memory.


The relationship of defensive language behavior in patient monologues to the course of psychoanalysis. Examined the relationship of the time-course of psychoanalysis to progressive alteration of defensive language behavior in 7 patients. Spontaneous 5-minute monologues were recorded over 1 1/2 years of three-times-a-week individual psychotherapy. Weintraub and Aronson's (1962) formal measures of defensive language were used: nonpersonal references, negators, qualifiers, retractors, explaining expressions of feeling, and evaluators. The magnitude of defensive speech displayed by a patient was able to predict significantly the duration of psychoanalysis undergone by that patient in 4 of 7 cases.


The empirical evaluation of the effects of different group treatment strategies against a controlled treatment strategy on behavior exhibited by antisocial children, behaviors of the therapist, and two self-rating scales that measure antisocial behavior. Evaluated two group treatment strategies against a control treatment strategy on the behaviors exhibited by antisocial children, behaviors of their therapists, and two self-rating scales. The first year 139 antisocial children were stratified according to age and then randomly placed into 14 groups. For the second year, 100 children were placed into 11 groups composed of antisocial children. Behavioral measurements of the children's and therapists' behaviors were secured at each weekly 2-hour meeting. Children were pre- and posttested on the various inventories postulated to measure antisocial behavior. In addition, significant adults, such as group therapists, filled out pre- and posttest inventories to measure antisocial behavior. For both years very few significant differences occurred between the treatment groups and the control groups on the dependent variables studies. The findings are discussed in terms of their relevance for behavior therapy.


Changing students' constructs of mental patients by means of educative seminars. Demonstrated that through a brief, didactic, demythologizing approach, college students' attitudes toward mental illness can be changed in a psychosocial or non-medical model direction. Furthermore, results indicate that such an approach effectively can change students' somewhat negative constructs of mental patients in a positive direction.


Problems with using dominance indices to evaluate family interaction patterns. Used four well-accepted behavioral measures of dominance to document changes in dominant/submissive behaviors of marital couples as a result of videotape feedback of behavior in decision-making tasks. Dominance scores for 30 normal couples on each of the four indices were correlated, and results indicated that the measures bore little relationship to each other. Further, a review of videotaped interactions revealed little to warrant even intuitive support for three of the measures. Such data support the contention that these popular indices may be inappropriate to assess dominance across couples.


Group decision-making and self-management in the treatment of psychiatric patients. Examined the effects of a treatment program of patient decision making and self-management upon the self-concept, locus of control and behavioral adjustment of psychiatric patients. It was hypothesized that patients exposed to the experimental treatment would reveal significantly higher levels of self-concept, lower levels of external control and more acceptable behavioral adjustment than patients who did not receive such treatment. Of the three dependent variables, only behavioral adjustment revealed significant changes after treatment. Ss who participated in the decision-making and self-management program displayed substantial gains in their level of behavioral adjustment, while the remaining Ss did not. Nonsignificant trends toward greater levels of self-concept and internal control also were observed in these Ss.


A cognitive-experiential approach to the interpersonal and intrapersonal development of counselors and therapists. Examined the effects of a training program for counselors and therapists based upon configurations of (a) systematic human relations training; (b) cognitive restructuring of counselor beliefs; and (c) systematic performance feedback. Criterion measures consisted of post vs. pre-gain scores on selected scales of the Personal Orientation Inventory and the seven Carkhuff scales. Results indicated that the most significant gains made on the criterion measures were evidenced by those Ss who participated in the training program that consisted of all three of the training conditions.


Psycholinguistic correlates of language predictability in psychiatric interviews. Applied the cloze technique to patient speech samples that were obtained from tape-recorded initial intake interviews in a psychiatric outpatient clinic. The findings indicated that cloze samples taken from the end of the interview were less predictable than those obtained from the beginning. Correlation with cloze change scores in discussed.


A test of Sarbin's self-role congruency theory within a role-playing therapy analogue situation. Explored the application of role playing, as a research technique, in a test of Sarbin's self-role congruency theory. Forty male Ss volunteered to play either the role of a therapist or client in a simulation of psychotherapy. The CPI dominance scale was used to select high dominant Ss to play the role of therapists. Half of these high dominant Ss were instructed in directive therapy (creating a self-role congruent condition with high dominance and directiveness being congruent) and half were instructed in non-directive therapy (creating a self-role incongruent condition). Judges' ratings were used to compare Ss' role playing ability and visible comfort between the self-role congruent and self-role incongruent conditions. The results supported Sarbin's theory of self-role congruence. These findings suggest methodological improvements in psychotherapy research via the use of role playing and have practical implications for the practice of psychotherapy.


Locus of control and perceived adjustment to life events. Investigated the relationship between locus of control orientation and perceived adjustment to critical life events. The Locus of Control scale and a modification of the Life Events scale were group administered to undergraduate students. No significant difference was found between internal and external scorers in the number of life events experienced during the 2-year assessment period. As predicted, external scorers reported a significantly more difficult adjustment to life events than internal scorers. The results suggest that it may be important for educators and mental health professionals to promote an internal locus of control orientation as a preventive and remedial approach to adjustment problems.


Therapeugenic factors in psychotherapy: the use of psychological tests. In the first part of the experiment all Ss were administered a battery of psychological tests that they were told would provide an accurate description of their personality. Two weeks later, Ss were contacted and asked to participate in the second half of the experiment. Half of the Ss were led to believe that the psychological assessment indicated that they could remain calm and relaxed when exposed to a stressful situation (therapeutic suggestion), while the other half did not receive this feedback (no suggestion). Half of the Ss then were exposed to a stressful situation (threat), while the other half were not (no threat); the effectiveness of the diagnostic predictions was assessed via physiological and self-report measures of arousal. Results indicated that (a) the threat manipulation was effective in creating stress; and (b) Ss given therapeutic-suggestion feedback based on the psychological assessment were able to remain significantly more calm and relaxed in the experiment than Ss who did not receive therapeutic suggestions. Implications for the use of psychological testing and diagnostic feedback as a technique of social influence are discussed.


Some personality correlates of the A-B therapist scale for male and female medical students. Provided more knowledge about the personality dimensions that underlie the A-B scale particularly with respect to potential sex differences. A-B scores of two samples, 155 male and 36 female medical students, were related to their scale scores from the Personal Orientation Inventory and the State-Trait Anxiety Inventory. Univariate analyses indicate that the present set of measures are related to A-B status for females, but not for males. For female medical students it appears that scoring as an A is associated with anxiety proneness, low self-esteem, constriction and introversion, rigidity, dependence, and guilt feelings. Implications of the present results and recommendations for future research with the A-B dimension are discussed.


Biofeedback-assisted EMG reduction and subsequent self-disclosure. A male E and a female E each conducted a single session of EMG biofeedback training with 24 male and 24 female Ss (N =96) under one of three conditions: verbal reinforcement presented contingently on EMG reduction, yoked noncontingent verbal reinforcement, and no verbal reinforcement. After the biofeedback session, all Ss completed a Journard Self-disclosure Scale. Sex of S and verbal reinforcement conditions did not affect EMG biofeedback performance, but Ss treated by the male E decreased EMG mean and standard deviation more than Ss treated by the female E (p less than .01). Ss who received noncontingent verbal reinforcement reported being least willing to disclose to the E (p less than .05). These results are discussed in terms of the interpersonal influences that may affect biofeedback performance and self-disclosure.


Coping effectiveness and dreams as a function of personality and dream recall. Investigated the proposition that effectiveness of coping with daytime and dream stress would be influenced by personality style, as defined by the Repression-Sensitization scale (R-S), and by dreaming style, as defined by frequent (F) or infrequent (I) questionnaire dream recall. The relationship between R-S and F-I dream recall also was explored. Ss kept dream diaries for 30 consecutive days. Sensitizers, who were I recallers, had very low daytime self-confidence scores. Repressors had more positive Dream Coping Scores than Sensitizers, and F recallers had more positive Dream Coping Scores than I recallers. Repressors had a positive morning mood, regardless of whether the ending of their dream was positive or negative. The morning mood of Sensitizers, particularly the I recallers, was dependent on the pleasantness-unpleasantness of the dream ending. R-S and F-I questionnaire dream recall had a low positive correlation; no relationship was found between R-S and F-I dream diary recall.


The interactive effects of instructional set, field dependence, and extraversion on the Holtzman Inkblot Technique. Studied the interactive effects of examiner, instructional set, field dependence, and extraversion on the reactions of 81 males and 39 females to five Holtzman Inkblot Technique factor scores. Half of the Ss were told that the HIT was a measure of mental health and half that it was experimental in nature, which produced two instructional sets. Field dependence was measured with the Embedded Figures Test and extraversion by the Eysenck Personality Inventory. Subjective anxiety was tapped via the State-Trait Anxiety Inventory. Results revealed no differences among five examiners. However, three of the five HIT factors and the STAI were affected significantly by the instructional set. The effects, while significant, were not massive. Field dependence interacted with instructional set; field dependent Ss reacted with generally more changes in scores than did field independent S. Unlike field dependence, extraversion appeared unrelated to instructional set effects. The results are discussed in terms of how the factor scores interacted with the field dependence and instructional set in psychologically meaningful ways.


Semantic representations of drug terms by industrial workers. Studied semantic representations of drug terms as a function of reported use of illicit drugs, with young-adult industrial workers as the Ss (college students served in a preliminary study). Procedures for describing semantic organizations included the semantic differential, similarity ratings, sorting, and verbal production of drug names. In general, structured representations of drug terms were produced, in line with the categories: illicit drugs, medicinal drugs, alcohol products, and substances containing nicotine or caffeine. Increased drug use was accompanied by more positive evaluations of illicit drugs on the semantic differential and more extensive clustering on the verbal production task. It was concluded that use of illicit drugs is accompanied by distinctive semantic representations, that these patterns mainly involve drugs used illicitly, and that they are most apparent on tasks in which responses are least constrained, such as verbal production.


Reliability and stability of the Comrey Personality Scales in a clinical setting. Examined split-half reliabilities, retest reliabilities, and stability of the Comrey Personality Scales (CPS) (Comrey, 1970) for a Navy sample of 200 young drug abusers tested at the beginning and end of rehabilitation in a no-feedback, compulsory participation setting. The pre-rehabilitation split-half reliabilities for the eight personality scales ranged from .73 to .94, with an average of .85, and ranged from .74 to .91, with an average of .83, on the post-rehabilitation administration. Retest reliabilities for the eight scales were between .39 and .64, with an average of .52. Post-rehabilitation means were significantly higher on four of the eight scales, and one scale mean was significantly lower. It is concluded that the CPS is appropriate in a clinical setting in which test participation is compulsory and test feedback is not made available to the respondents.


Need similarity in husbands and wives who are receiving methadone maintenance therapy. Investigated whether a common dimension of need similarity underlies marriages in which both partners are receiving methadone maintenance therapy. Thirty couples who were receiving methadone maintenance therapy for their heroin addiction were asked to complete the Marital Adjustment Test and Adjective Check List. A canonical correlation analysis was performed between the husbands' and wives' Adjective Check List need scores. One dimension was found that was related positively to the husbands' needs for Dominance, Affiliation, Heterosexuality, Exhibition, and Change, whereas the same dimension was related positively to the wives' needs for Achievement, Dominance, Endurance, and Intraception. It was concluded that Dominance revealed a complementary relationship in which the marriage was meeting the husbands' social needs and the wives' intrapsychic needs.


An expectancy-value theory approach to the long-term modification of smoking behavior. Despite the research interest in modifying smoking behavior, therapeutic treatments that can produce long-term cessation have not been demonstrated rigorously. A follow-up study of two attitude change experiments (N = 173) examined the effects of a fear appeal, that is, increasing smokers' awareness and appreciation of the highly noxious consequences of smoking. Although this familiar type of information may be an integral component of many smoking treatment programs, its long-term suppressive effect has not been demonstrated in well-controlled experiments. The results disclosed that 3 months and also 1 year after treatment, a high-fear manipulation had increased significantly the percentage of smokers who were able to stop smoking completely.


The effect of marihuana intoxication on blood pressure. Forty-eight experienced marihuana smokers were assigned to one of four groups: coltsfoot, placebo, low dose marihuana and high dose marihuana. While both marihuana groups showed significant increases in subjective ratings of intoxication and pulse rate, blood pressure readings were unaffected or showed a modest decrease. This latter finding is discrepant with previous studies and is explained in terms of a drug X person interaction present in those studies.


Internal-external control and withdrawal AMA from an alcohol rehabilitation program. Male and female alcoholics who were participating in an in-patient rehabilitation program were given the Rotter internal-external control scale in order to determine whether there were differences between those who leave against medical advice vs. those who complete treatment. It was anticipated that AMA patients would have significantly higher scores than completers. The hypothesis was given some support for males (p less than .06) and was not supported for females. Males and younger patients also were more inclined to leave against medical advice.


Golgi-staining of "primary" and "secondary" motoneurons in the developing spinal cord of an amphibian. The Golgi technique was used to study the morphology of spinal motoneurons at various stages in the early development of swimming behaviour in embryos and larvae of the palmate newt, Triturus helveticus ((Razoumowsky). The earliest motoneurons stained appeared to be associated with the Mauthner-cell system. The overall morphology of these "primary" motoneurons seems to be similar throughout the lower vertebrates and the distinctive characteristics found in earlier descriptions of those from caudate amphibia were probably due to misinterpretation. At about the time of hatching and development of low-frequency swimming behaviour, other motoneurons were found to innervate the axial musculature, cells with a central morphology different from those of the "primary" type. It was found likely that these "secondary" motoneurons innervate a separate muscle system concerned with tonic and "slow phasic" activity, while "fast phasic" acitivity in rapid swimming is supplied by "primary" cells.


The number and distribution of ganglion cells in the cat's retina. The number of ganglion cells in the cat's retina, and the pattern of their distribution over the retina, have been reinvestigated. Criteria are presented for the identification of ganglion cells in Nissl-stained whole mounts, most particularly for the distinction between small ganglion cells and neuroglial cells, by reference to retinas with no ganglion cells (obtained by nerve section) and to areas to retina containing a population of only small ganglion cells (obtained by optic tract section). Using these criteria, the number of ganglion cells was counted in four retinas (mean total 116,250). The number of large or "giant" cells (presumably the somas of Y-cells and of alpha-cells) varied from 4,200 to 7,100. Overall these cells comprised 4.0-6.3% of the total ganglion cell population. Their distribution over the retina showed a concentration around the area centralis, with a localized minimum density at the area centralis, and a concentration in the visual streak. These concentrations of large cells were quantitatively less than the concentrations of smaller cells in the area centralis and visual streak, so that the relative frequency of large cells was minimal (mean 1.6%) at the area centralis and increased steadily up to 5.5-6.9% in peripheral retina. Their relative frequency was distinctly lower along the visual streak than in peripheral retina above or below the streak.


Retinal abnormalities in the Siamese cat. Ganglion cell density maps of the retinas of Siamese cats show the same major features of ganglion cell distribution as are found in normally pigmented cats, in particular the area centralis and visual streak. In the retinas of the seven Siamese cats investigated, however, the areas centralis was "underdeveloped" when compared with the normally pigmented cat. The peak ganglion cell density was lower and the ganglion cells usually larger than at the area centralis of the normally pigmented cat, and the characteristic blood vessel pattern around the area centralis was less developed. One animal showed a marked blood vessel abnormality, a vessel crossing the area centralis in each retina. In another animal, the distribution of ganglion cells appeared abnormal throughout the retina. Medium-sized, possibly X-type ganglion cells were lacking from all retinal areas, overall cell numbers were low and the distribution of ganglion cells showed a prominent visual streak.


The nasotemporal division of retina in the Siamese cat. By sectioning one optic tract in Siamese kittens and allowing sufficient time for the affected ganglion cells to degenerate and disappear, we have obtained maps of the distribution of ipsi- and contralaterally projecting ganglion cells in the retina of the Siamese cat. As previous work predicted, many ganglion cells in the Siamese cat retina project contralaterally which, in the normally pigmented cat, would project ipsilaterally. The transition from the pattern of projection typical of nasal retina (all contralateral) to that typical of temporal retina (most ipsilateral) is much more gradual in the Siamese cat than in the normally pigmented cat, and is centred 1.7-3 mm temporal to the area centralis, instead of at the area centralis. In the Siamese cat only a few ganglion cells at the area centralis project ipsilaterally, as against nearly 50% in the normally pigmented cat. The proportion of ipsi-projecting cells reaches the 50% level 1.7-3.0 mm into temporal retina, and overall the zone of transition may be several millimetres wide, as against about 0.2-0.5 mm in in the normall pigmented cat. Evidence is presented that the degree of the abnormality of nasotemporal division varies between individual Siamese cats and that the abnormality is more severe among large or "giant" cells than among the population as a whole.


Estimate of the number of myelinated axons in the cat's optic nerve. The number of myelinated axons in the cat's optic nerve has been estimated from a partial count of sections of the nerve examined by electron microscopy. The average count obtained from four nerves was 128,600 (range 112,800-147,200). This figure is within 10% of a previous estimate of the number of ganglion cells in the cat's retina, but is 33% lower than the only previous estimate of the number of these axons based directly on electron microscopy. Possible sources of the discrepancy are discussed. The functional implications of this total, in the context of earlier work on ganglion cell topography, are also discussed.


Sites on termination on the saccular macula of auditory nerve fibers in the goldfish as determined by intracellular injection of procion yellow. Procion yellow dye was injected intracellularly into large auditory fibers of goldfish to  investigate the relationship between the response type of these fibers and their site of termination in the saccular macula. Fibers which responded to the rarefaction phases of sound were found to terminate on the hair cells located in the ventral half of the saccular macula, while those which responded to the compression phases were found to terminate on the dorsally located hair cells. A third group of fibers, which responded to both sound phases, was found to bifurcate outside the saccular macula and terminate on both dorsally and ventrally located hair cells. Some of the fibers of this group were found to trifurcate before entering the saccular macula. Results obtained in the present study, in conjunction with the findings on the orientation of hair cells within the sensory macula, can explain the mechanism underlying the presence of three different response types of fibers in the auditory nerve of the goldfish.


Fine structure of reactive cells in injured nervous tissue labeled with 3H-thymidine injected before injury. To examine the fine structure of blood mononuclear cells in injured nervous tissue, mice were given repeated injections of 3H-thymidine with the last injection at least 16 hours before injury. Under ether anesthesia the animals either were given a stab wound to the spinal cord or had their left hypoglossal nerve transected. The animals were killed at 2, 4, 8, or 16 days after injury. Tissue sections containing the spinal cord wound or both hypoglossal nuclei were prepared for electron microscopic radioautography, and all labeled cells were photographed. About half the labeled cells in the injured spinal cords and almost all the labeled cells in the nuclei of the injured hypoglossal nerves had nuclei with dark staining peripheral heterochromatin, dark cytoplasm with long cisternae of granular endoplasmic reticulum, and other ultrastructural features characteristic of the cells usually identified as microglia. The remaining labeled cells in the injured spinal cords were macrophages, fibroblasts, cells with pale nuclei, some of which contained cytoplasmic filaments, and vascular cells. Since uninjured nervous tissue has extremely few labeled cells and since 3H-thymidine should be available for only a short time following injection, most of the labeled cells in this experiment should be derived from blood mononuclear cells. However, the possibility is discussed that some or all of the labeled cells may be intrinsic cells proliferating in response to the injury and labeled through reutilization of labeled DNA precursor material.


Reconstruction of trajectory of primary afferent collaterals in the dorsal horn of the cat spinal cord, using Golgi-stained serial sections. Using Golgi-stained serial sections obtained at the sacro-caudal levels of the cat spinal cord, it was possible to reconstruct the trajectory of primary afferents. They were classified into two groups: reliable primary afferents directly traced from the dorsal root and probable primary afferents traced from the dorsal funiculus or Lissauer's tract. The diameters of the reliable primary afferents vary from 0.88-1.88 mum. According to their courses, reliable primary afferents as well as probable primary afferents were classified into three groups: the first is distributed to both medial and lateral halves of the dorsal horn, the second to the medial half, and the third to the lateral half. Commissural fibers were also observed among the probable primary afferents. The rostro-caudal and medio-lateral extents of reliable primary afferents are found to be between 250 and 950 mum and 270 and 700 mum respectively, while those of the probable primary afferents were between 125 and 670 mum and 270 and 1,640 mum respectively. These primary afferent fibers are connected with at least two or more laminae of the dorsal horn gray matter.


Scanning electron microscopic study of the otolithic organs in the bichir (Polypterus bichir) and shovel-nose sturgeon (Scaphirhynchus platorynchus). The anatomy and ultrastructure of the sacculus, lagena, and utriculus of the ear of Polypterus bichir and Scaphirhynchus platorynchus were studied using the scanning electron microscope. The otolithic organs each contain a single dense calcareous otolith in close contact with a sensory epithelium (macula). The maculae have sensory hair cells typical of those found in other vertebrates, surrounded by microvilli-covered supporting cells. The hair cells on each macula are divided into several groups, with all of the cells in each group morphologically polarized in the same direction. The cells of the utricular macula in both species are divided into opposing groups in a pattern similar to that found in other vertebrates. The saccular and lagenar maculae are located in a single large chamber in both species. In Scaphirhychus the two maculae are on the same plane, while in Polypterus they are at right angles to one another. The hair cells on the saccular maculae of both species are divided into two oppositely oriented groups. In Scaphirhynchus the cells on the posterior half of the macula are oriented dorsally on the dorsal half of the macula and ventrally on the ventral half. The anterior region of the macula is rotated and the cells of the dorsal and ventral groups are shifted so that they are oriented on the animal's horizon plane. A similar pattern is found in Polypterus, except that this macula is shaped like a "J" with the vertical portion of the J having horizontal cells and the bottom portion vertical cells. The lagenar maculae in both species have dorsally oriented cells on the anterior side of the macula and ventrally oriented cells on the posterior half of the macula. While these data are not sufficient for clarifying the taxonomic relationship between the two species studied, it is clear that the ears in these species have a number of significant differences from the teleost ear that could have functional and/or taxonomic significance.


Myelin sheath thickness and conduction latency groups in the cat optic nerve. In many animals, the optic nerve has multiple conduction latency groups of fibres yet displays a unimodal frequency distribution of fibre sizes. An attempt has been made to resolve this discrepancy in the cat. Examination of teased preparations of fixed cat optic nerve fibres by polarizing interference light microscopy indicated that a fibre's size may change abruptly along its length. Furthermore, the diameters of single nerve fibres followed for distances of up to 30 mum in serial transverse sections of cat optic nerve showed variations of up to 100% of a fibre's average diameter over that distance. On the other hand, the myelin sheath thickness of these fibres appeared to be relatively constant along any one fibre. A population of cat optic nerve fibres which had a unimodal axon diameter frequency distribution was found to have a myelin sheath thickness frequency distribution with five modes. These modes have been interpreted as indicating the existence of five groups of fibres in the cat optic nerve. Four of these groups may be related to four negative peaks seen in the antidromic compound action potential recorded at the margin of the cat optic disc following stimulation of the optic chiasm. The fifth myelin thickness group appears to represent the slowly conducting fibres which do not make an obvious contribution to the antidromic compound action potential. It is concluded that for the cat optic nerve, the conduction latency groups seen in the compound action potential may be more directly correlated with the frequency distribution of fixed nerve myelin thickness than with the frequency distribution of fixed nerve fibre diameter.


A light and electron microscopic study of the pineal in the blind goby, Typhlogobius californiensis (Pisces: Gobiidae). The pineal of the burrow-inhabiting, blind goby, Typhlogobius californiensis, was studied by light and electron microscopy. The two predominant cell types were photoreceptor and supportive cells. Ganglion cells could not be positively identified. The majority of photoreceptor cells had well developed outer segments and made apparent synaptic contact with nerve processes of unknown origin. Similar unmyelinated nerve fibers containing dense-cored vesicles were seen descending the pineal stalk. The cytoplasm of supportive cells contained several Golgi zones, occasional dense aggregations of smooth endoplasmic reticulum, abundant quantities of glycogen, some dense-cored vesicles and unusual rod crystalline inclusions measuring approximately 0.5 micrometer in width and 4-5 micrometer in length. These observations suggest that the pineal in this light-deprived species has retained its photoreceptive function and is a metabolically active organ which may also function in secretion.


Postnatal synaptogenesis in the rat interpeduncular nucleus. The rat interpeduncular nucleus (IPN) was studied by electron microscopy from the day of birth to 33 days of age. The habenulointerpeduncular (H-IPN) axons, the principal afferents to IPN, were prominent at birth, occurring in large groups. They formed occasional S synapses en passant at this time. S synapses subsequently increased progressively in number and maturity until 28 days of age. Crest synapses, also formed by the H-IPN axons, appeared at eight days without a recognized formative stage. They exhibited their diverse adult morphology by 14 days of age. F synapses, endings of uncertain origin that contain flattened vesicles, were seen at 21 days, although endings containing small vesicles at 14 days represented the same population. Axosomatic synapses were first seen at four days and remained infrequent subsequently. Dendritic growth cones had their maximal prevalence at birth, decreased at four days and were absent by six days of age. Thus each of the four synaptic types previously described in the adult rat IPN exhibited a characteristic time of appearance and pattern of development in normal rat pups. This well-ordered sequence of synaptogenesis makes the  H-IPN system well suited for a study of synaptic plasticity.


Effect of neonatal deafferentation on synaptogenesis in the rat interpeduncular nucleus. Changes in the normal synaptogenetic pattern of the interpeduncular nucleus (IPN) were induced by destruction of one or both habenular nuclei in neonatal rats. The S synapses, the principal habenulointerpeduncular (H-IPN) afferents, were reduced in number and delayed in time of appearance by unilateral lesions. They were eliminated by bilateral lesions. The crest synapses,  also of habenular origin, appeared at ten days of age and were apparently normal in structure after unilateral lesions. However, this actually represented a change in connectivity, since normal crest synapses are of bilateral origin. Following bilateral habenular lesions abnormal crest synapses appeared at 28 days of age. These had normal postsynaptic structure, but presynaptically were formed by non-habenular axons, usually of two different types of each crest synapse. Lesions induced an early appearance of F synapses, at three days, instead of the normal time after six days of age. Apparently similar processes containing flattened vesicles formed somatic contacts only in lesioned animals beginning at 21 days of age. The axosomatic synapses which were only occassional in the adult appeared at the normal time in lesioned animals. At 28 days of age in both unilaterally and bilaterally lesioned animals there was an increase in the number of somatic synapses. This increase was due to an increase of the normal somatic endings plus the appearance of somatic synapses containing flattened vesicles. Both types of somatic contacts were found in similar numbers at subsequent ages up to three months. The changes in S synapses represent Wallerian degeneration. The formation of unilaterally derived crest synapses in unilaterally lesioned animals is interpreted as evidence for a specific recognition mechanism. A postsynaptic control mechanism is proposed to explain the formation of heterologous crest synapses, with the usual distinctive geometry but involving abnormal, non-habenular presynaptic elements four weeks following neonatal bilateral lesions. The increase in axosomatic synapses is unusual since the dendrites of IPN neurons were deafferented, not their somata. The factors leading to the changes in somatic synapses are discussed. The findings reveal new examples of the complexity of neuronal adaptation to CNS lesions in early life.


Development of species identification in ducklings: IV. Change in species-specific perception caused by auditory deprivation. The purpose of the present experiments was to identify the change in species-specific perception that underlies the aurally deprived ducklings' lack pf preference or discrimination in the mallard versus chicken call test. Among other acoustic differences, the mallard and chicken maternal calls differ in repetition rate (3.7 and 2.3 notes/sec, respectively). The present experiments showed the dimension of repetition rate to be uppermost in the perceptual hierarchy underlying the auditory aspect of species identification in Peking ducklings. The relatively narrow species-typical repetition-rate preferences of normal Peking ducklings (about 4--6 notes/sec) is lacking in the aurally deprived ducklings, and they respond to lower rates than usual (2.3 notes/sec). This broadening of the range of responsiveness on a perceptual dimension (repetition rate) that is basic to species identification accounts for the devocal ducklings' lack of discrimination in the mallard versus chicken call test.


Frequency selectivity in the parakeet (Melopsittacus undulatus) studied with psychophysical tuning curves. Seven parakeets were trained to avoid shock during pure-tone stimulation. A modified method of limits was used to measure detection thresholds of the pure tones. The intensity of masker tones, at numerous frequencies, was varied in order to measure the masked threshold of a probe-tone signal set at a fixed frequency and intensity. Masking curves were obtained for three probe tones (.63, 1.6, and 2.5 kHz) at each of five sensation levels (10, 20, 30, 40, and 50 dB). The masking curves from this procedure are frequently referred to as "psychophysical tuning curves" and provide an indication of frequency selectivity. The results are compared with analogous data in other species and suggest that frequency analysis in the parakeet ear is somewhat less accurate than in the mammalian ear.


Chick vocalization and emotional behavior influenced by apomorphine. For the purpose of studying the role of dopamine (DA) in the causation of vocalization and other behavior in domestic chicks, 5-day-old birds were injected with 1 mg/kg doses of apomorphine hydrochloride, and their behavior was recorded by methods of direct observation. The effects of the drug on birds with bilateral lesions of the intercollicular nucleus (a vocal area) and on birds pretreated with the DA antagonists pimozide and haloperidol were also examined. In intact chicks, apomorphine induced trills, facilitated twitters, and inhibited warbles. Pecking at conspicuous objects in the cage and locomotion were increased, whereas the duration of eye closure was reduced. In chicks with lesions there was no facilitation of trills, twitters, or pecking, whereas the other drug-induced behavioral effects were as in intact chicks. Dopamine antagonists blocked the trills and twitters facilitated by apomorphine but did not protect against the inhibition of warbles. It is concluded that trills, twitters, and pecking are produced by activation of dopaminergic mechanisms. It is hypothesized that some of the behavior induced by apomorphine, especially vocalization and pecking, are a consequence of altered states of attention induced by the drug.


Influence of gonadal hormones and sexual behavior on ultrasonic vocalization in rats: I. Treatment of females. Ultrasonic vocalizations were measured when male rats were placed with ovariectomized females that had experienced various hormonal and behavioral treatments. In Experiment 1, 18 males were tested with females in each of the following conditions: nonestrous (OVX), estrogen treated (E), estrogen and progesterone treated (EP), and estrogen and progesterone treated and given two intromissions from a stud male prior to testing (EPI). Control conditions included clean cage (CL) and cage soiled by an estrous female (SOI). The treatments differed in effect on rate and maintenance of vocalization: EP greater than E greater than EPI = OVX greater than SOI greater than CL. In tests in which males produced a high rate of vocalization, some males with short intromission latencies shifted from the normal 50-kHz pulse to a 22-kHz pulse. In Experiment 2, the effect of the female's vocalization and movement on the rate of and latency to vocalization was measured. Twenty-one males were presented with each of the following stimulus conditions: estrous female with red light (EP), estrous female without red light (EP dark), estrous anesthetized female (EP anes), and nonestrous anesthetized female (OVX anes). Effects on vocalization of various treatments were as follows: EP = EP dark greater than EP anes greater than OVX anes. These data suggest that the 50-kHz vocalizations constitute a graded response influenced by the female's hormonal and sexual condition.


Movement discrimination capacities in the cat. Cats were trained to discriminate moving from nonmoving targets or one direction of movement from another. Various stimulus changes, e.g., size, direction, and rate, were then introduced as a test for generalization of the dimension of movement. Thresholds for detection for minimal movement were also determined. The results showed that (a) for cats, discrimination of movement is more difficult than discriminations based on brightness; (b) the dimension of movement is completely generalized across stimulus configuration but incompletely generalized for direction of movement; (c) the mean movement detection threshold was found to be 3.3 degrees/sec; (d) the thresholds for minimal movement and direction of movement were essentially identical; and (e) stimulus-viewing strategies were found to play an important role in the threshold determinations. The results of the generalization tests are consistent with the physiological properties of neurons found to be sensitive to movement in the cat visual system. The movement threshold values were found to lend support to the view that resolution and slow movement thresholds are correlated.


Water and NaCl intake after furosemide treatment in sheep (Ovis aires). Intravenous infusion of the natriuretic drug furosemide in sheep led to the excretion of large quantitites of hypotonic urine. The sheep consumed more water than was needed simply to restore osmotic equilibrium. The stimulus for the additional intake was presumably hypovolemia resulting from the loss of sodium in urine. Despite the natriuresis, in only 2 of 15 experiments did sheep drink significant amounts of .5 M NaCl solution during the first 10 hr after the onset of furosemide treatment, and hemoconcentration and arterial hypotension were evident during this time. By 24 hr, however, the saline consumption in all but three experiments had increased and compensated adequately (together with the water intakes) for the furosemide-induced loss of sodium-rich fluid in urine. These results provide evidence that following acute hypovolemia in sheep, as in rats, the onset of sodium appetite is delayed relative to the appearance of thirst.


Response suppression on DRL by rats with septal damage. The effectiveness of the differential reinforcement for low rates of responding (DRL) contingency in suppressing response rates of septal rats was investigated by using a Multi-DRL-yoked-VI (variable interval) schedule of reinforcement. The yoking procedure equated the interreinforcement times on the two schedules. Each schedule was in effect for half of each session, and the change in schedule was signaled by the presence or absence of a cue light. Schedule order and DRL delay requirement were varied. For both normal and septal rats, the response rates were higher in the VI component than the DRL component; this effect demonstrates that the responding of septals as well as normals is suppressed by the differential reinforcement of a particular class of IRTs. A sharp difference in the level of responding occurred at the point of transition from one component of the multiple schedule to the other, which provides evidence of a discrimination between the two schedules for both normals and septals. The conclusion is that the responding of septals is suppressed by the DRL contingency and not controlled solely by the density and distribution of reinforcement.


Effect of self-determined intravenous infusion of hypertonic NaCl on Na appetite of sheep. The time delay that occurs between a rapid, systemically produced change in Na balance and a change of voluntary Na intake was examined in Na-deficient sheep with a parotid fistula. They were trained to bar press in order to replace a daily Na deficit of 300--500 mmol. During basal conditions on different days, each delivery to a drinking cup consisted of either a small or a large amount of NaHCO3 solution. In the experimental situation, the small amount of NaHCO3 was delivered to the cup, but total Na delivered was made to equal that of the large amount by automatic concurrent infusion of hypertonic NaCl intravenously with each delivery to the cup. As a control, the concurrent intravenous infusion was .15 M NaCl, which had little influence on Na balance. A significant difference in the cumulative number of deliveries between the hypertonic and isotonic NaCl infusion conditions occurred by 10--20 min. It is concluded that systemic injections of hypertonic NaCl are effective within 10 to 20 min in reducing the sodium appetite of Na-depleted animals.


Effects of experience on interocular transfer of pattern discriminations in split-chiasm and split-brain cats. Interocular transfer of monocularly learned pattern discriminations was found to be imperfect in split-chiasm cats but to improve as a result of specific practice with interocular transfer tasks. Section of the forebrain commissures subsequently performed in these animals abolished immediate interocular transfer of pattern discriminations. However, there were some savings in reattaining the learning criterion with the second eye. Other cats that learned the same discriminations monocularly but had sustained a combined section of optic chiasm and forebrain commissures before learning showed no indication of interocular transfer. These data suggest that the commissural systems involved in interocular and interhemispheric transfer of pattern discriminations may be modified by practice and learning. Further, it is possible that the intervening transfer experience between the section of the optic chiasm and that of the forebrain commissures results in the persistence of some capacity for interocular transfer of pattern discriminations after commissurotomy. However, this residual capacity may be negligible when compared with the capacity for interocular transfer of split-chiasm cats with intact forebrain commissures.


Escape from deficits in sodium intake after thalamic lesions as a function of preoperative experience. Saline and water intakes in response to treatments with a natriuretic agent and a mineralocorticoid were studied in intact rats and in rats with lesions centered in the taste delay of the thalamus. Intact rats responded to the treatments by increasing both saline and water intake. Rats with thalamic lesions that had never drunk saline prior to induction of the lesions generally did not increase their saline intake in response to the treatments but showed normal increases in water intake. In contrast, rats with thalamic lesions that had drunk saline prior to induction of the lesions showed normal increases in both saline and water intake. Preoperative experience of sodium need did not protect rats against the lesion-induced deficit.


Insulin and glucagon as determinants of body weight set point and microregulation in rats. Seven adult male rats were observed for body weight and microregulation (feeding, drinking, and running patterns) after manipulation of insulin and glucagon levels. They received three injections per day for 3 days each week of 3 U of protamine zinc insulin, .25 mg of zinc glucagon, 50 microgram of protamine zinc somatostatin (SRIF), or protamine zinc vehicle. Diabetes was then induced with an iv injection of streptozotocin (65 mg/kg), and the injection schedule was repeated after the full diabetic syndrome emerged. In all rats whose insulin levels were increased relative to glucagon levels, body weight increased; in those whose glucagon levels were increased relative to insulin levels, body weight decreased. All injections except vehicle reduced meal sizes in both normal and diabetic rats, but only insulin increased the frequency of feeding. These effects could be predicted by the glucostatic theory of food intake regulation and are thus interpreted as supportive of this theory. These results also support the hypothesis that the relative concentration of insulin to glucagon is a regulator of body weight set point.


Dyskeratosis benigna intraepithelialis mucosae et cutis hereditaria. A report of this disorder in father and son. A congenital syndrome affecting the skin, oral mucosa and bulbar conjunctiva is reported in father and son. Skin lesions consisted of brownish papules with central keratotic plugs. Trauma was able to provoke lesions. In addition, changes of oral mucosa with premature loss of the teeth, and recurrent eye symptoms with conjunctivitis were present. Histological examination of specimens from skin, oral mucosa and conjunctiva revealed a uniform picture of dyskeratosis (single cell keratinization). The symptoms reported do not seem to fit into any of the existing muco-cutaneous syndromes. An autosomal dominant mutation is suggested as the cause of the disease.


Cutis laxa (generalized elastolysis). A report of four cases with autopsy findings. Four children with cutis laxa (generalized elastolysis) are reported. The first three cases were siblings from a Canadian Indian family and the fourth case was the only affected child in an American Black family. Loose and sagging skin folded over the face, neck and trunk, gave a premature senile appearance. Post-mortem examination was performed on the first three cases. The most common and serious visceral involvement was development of pulmonary emphysema. This was present in two autopsied cases and was demonstrated by chest X-ray in the fourth case. Other abnormalities included large inguinal and perineal hernia, rectal diverticulum and multiple diverticulae of the urinary bladder.


3H-thymidine labeling of epidermis in morbus Darier. 3H-thymidine incorporation into epidermal cells of four patients with morbus Darier was studied by an in vitro technique. The labeling index counted on 0.5 mu thick plastic sections was 13.7 +/- 5.3, indicating increased epidermopoieses in morbus Darier.


Lipid metabolism in non-uremic and uremic dogs during and after hemodialysis with acetate. Plasma triglyceride and cholesterol concentrations were elevated in dogs after nephrectomy induced uremia. Plasma triglyceride concentrations remained constant during a 4-hour period of hemodialysis of uremic and non-uremic dogs against an acetate concentration of 39.5 mM (delivering 3 mEq/Kg/hr) plus infusion of 12.5 muCi/Kg/hr of acetate-1-14C, but rose progressively following dialysis. Radioactivities in plasma phospholipids, triglycerides and cholesteryl esters increased during dialysis and continued to rise in the post dialysis period, whereas 14C activity in free fatty acids and free cholesterol increased during dialysis and decreased post-dialysis. Acetate 14-C incorporation into plasma triglycerides was similar in the uremic and non-uremic groups, but incorporation into plasma cholesterol was higher in the uremics. Liver triglyceride concentrations and radioactivities at 12 hours were higher in the uremic dogs. At this time, adipose tissue 14C incorporation was also higher in uremic dogs but no differences were observed in aorta, heart or sciatic nerve incorporation. The results suggest that acetate may contribute to the increased plasma triglyceride concentrations observed following dialysis, and that uremia further accentuates acetate incorporation into plasma cholesterol and liver triglycerides.


Augmented peritoneal mass transport with intraperitoneal nitroprusside. Lightly restrained, alert New Zealand white rabbits underwent peritoneal dialysis by percutaneous instillation of standard dialysis solution with or without intraperitoneal nitroprusside. Corrected to a mean intraperitoneal dwell time of 36 minutes, mean clearances of creatinine and urea were 0.74 and 0.90 ml/kg/min in six rabbits. With intraperitoneal nitroprusside, 1.13 mg/kg clearances increased to 1.13 and 1.30 ml/kg/min (p less than 0.01) respectively. The 53% increment in creatinine clearance maintained the ratio clearance larger/smaller solute suggesting increased peritoneal permeability and/or area. Lower nitroprusside doses were less effective and not significantly above control. Nitroprusside also increased clearances during hypertonic peritoneal dialysis, but had no effect on osmotically induced water flux. Lavage studies demonstrated a persistent effect of nitroprusside after a single exposure and a sustained effect with repeated use.


Critical appraisal of haemofiltration and ultra-filtration. The development of ultra-short dialysis: preliminary results. The clinical experience obtained with 2 hours every other day recirculation dialysis, using 20-40 liters of dialysate, without sorbents, and standard cuprophane dialyzers of 1.0-1.5 sq.mt. is reported. So far, over 350 treatments in 8 patients have been performed. After 2 hours of treatment the removal of urea, creatinine, phosphate and uric acid, is similar to that obtained by 4-6 hours of haemofiltration. The alkalinazation of the patient through direct venous infusion of bicarbonate, makes predialysis acid-base significantly better than in standard haemodialysis and haemofiltration. Asymptomatic correction of severe fluid overload is easily obtained like in isolated ultrafiltration. The role of osmolality and vasopressors are discussed. A dry weight below the value obtained by previous dialysis treatment is achieved, and volume dependent hypertensions as in haemofiltration are corrected after 2-8 weeks. As an additional advantage, this method offers a highly semplified technical approach and a further reduction of the dialysis time.


Self-care and home dialysis-role of social work. Social work intervention in Self-Care involves evaluation, preparation, crisis-intervention and ongoing assessment and support. Early introduction of this modality is considered vital and factors of age, education, socio-economic level, sensory and environmental conditions are considered in the evaluation process. The social work relationship with patients is described within the context of family and community supports. Experience has demonstrated that patients with pre-existing adaptation problems may require more concentrated social work counseling. The goals of independence and rehabilitation are shown to be effected by patient motivation and economic restrictions. The social worker participating in the team approach is described as contributing to the patients opportunity for self-determination through patient advocacy, supportive services and social action. Self-Care patients are considered as having high potential for achievement and satisfaction.


Psychological aspects of self-care and home dialysis. Self-care and home dialysis encourages the patient's active participation in his treatment which may enhance coping and adaptation to his illness. The psychological issues of dependence-independence, activity-passivity, and control and mastery are frequently referred to in the literature as being important in understanding the chronic stress of illness and treatment. The measure of successful coping should be determined by adaptive or maladaptive value of behavior rather than traditional concepts of normality or abnormality. Treatment planning and patient selection should be tailored to the psychological needs of the patient, the family and the staff. Several clinical vignettes are presented to illustrate that initial impressions of patient suitability for self-care and home dialysis may be deceiving. The medical staff plays an important role in influencing the patient's adaptation and coping.


Incidence of cervical cancer by marital status. The incidence of invasive cervical cancer by age and marital status was examined, using census statistics and 1968--71 cancer registry data from women who lived in the Manchester Regional Hospital Board area. The relative rarity of the disease in the unmarried and its higher incidence in formerly married than in currently married women was confirmed. This higher incidence was shown to be mainly in widows under 50 and divorced women, suggesting that it is related to the association of the disease with number of sexual partners.