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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Anticonvulsants, Biomarkers, Case-Control Studies, Epilepsy, Female, Fetal Blood, Humans, Infant, Newborn, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Protein Precursors, Prothrombin, Reference Values, Vitamin K, Vitamin K Deficiency.
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Does supplementation of vitamin K in pregnant women receiving anticonvulsant therapy prevent neonatal vitamin K deficiency? Context: The null hypothesis of this study is that extra vitamin K administered to pregnant women on a regimen of enzyme-inducing anticonvulsant therapy will not decrease the frequency of symptoms of vitamin K deficiency in their neonates. A multicenter case-control study was performed on 16 pregnant women on anticonvulsant therapy who received 10 mg of vitamin K1 daily from 36 weeks of pregnancy onward. Concentrations of PIVKA-II (protein induced by vitamin K absence for factor II) and of vitamin K1 were determined in cord blood and compared with those in 20 controls. In none of 17 cord samples was PIVKA-II detectable, compared with 13 of 20 in controls (chi 2, p < 0.001). Median cord vitamin K1 level was 530 pg/ml compared with below detection limit in most controls.
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Antenatal vitamin K1 treatment decreases the frequency of vitamin K deficiency in neonates of mothers on anticonvulsant therapy. Final Decision: yes