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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: MATERIALS AND METHODS, RESULTS. Meshes: Animals, Apoptosis, Brain Ischemia, Cell Death, Disease Models, Animal, Glucagon-Like Peptide 2, Glutathione, Hippocampus, Male, Malondialdehyde, Neuroprotective Agents, Oxidative Stress, Peroxidase, Rats, Rats, Sprague-Dawley, Reperfusion Injury, Superoxide Dismutase.
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Does Glp-2 have a protective effect on cerebral ischemia/reperfusion model? Context: Animals were randomized into 4 groups: sham, I/R + 0.9% NaCl, I/R + pre-Glp-2, and I/R + post-Glp-2. Cerebral ischemia was performed via the occlusion of the bilateral internal carotid artery for 40 min and continued with a reperfusion process. At the end of 6 h of reperfusion, animals were decapitated in all groups and brain tissues were removed. Malondialdehyde (MDA) and natural intracellular antioxidant glutathione (GSH) levels and myeloperoxidase (MPO) activities were measured in the left hippocampal tissue. The right hippocampal tissues of all group members were taken for histopathologic study. MDA levels and MPO activities increased from Group I to Group II and decreased from Group II to Groups III and IV. On the other hand, GSH levels were not significantly different among the groups. The number of apoptotic hippocampal tissue cells increased from Group I to Group II and decreased from Group II to Groups III and IV.
assistant
Our preliminary study revealed that Glp-2 treatment may decrease oxidative damage from I/R in cerebral tissue.