system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 67-year-old woman comes to the physician for the evaluation of bilateral knee pain for the past year. She reports that the pain is worse with movement and is relieved with rest. She has type 2 diabetes mellitus. The patient says her mother takes leflunomide for a “joint condition.” The patient's medications include metformin and a multivitamin. She is 165 cm (5 ft 5 in) tall and weighs 85 kg (187 lb); BMI is 31.2 kg/m2. Vital signs are within normal limits. Physical examination shows pain both in complete flexion and extension, crepitus on joint movement, and joint stiffness and restricted range of motion of both knees. X-ray of the knee joints shows irregular joint space narrowing, subchondral sclerosis, osteophytes, and several subchondral cysts. There is no reddening or swelling. Which of the following is the most appropriate pharmacotherapy?
assistant
Administration of ibuprofen