system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 57-year-old man presents to his family physician for a checkup. He has had type 2 diabetes mellitus for 13 years, for which he has been taking metformin and vildagliptin. He has smoked 10–15 cigarettes daily for 29 years. Family history is irrelevant. Vital signs include: temperature 36.6°C (97.8°F), blood pressure 152/87 mm Hg and pulse 88/min. Examination reveals moderate abdominal obesity with a body mass index of 32 kg/m². The remainder of the examination is unremarkable. His fasting lipid profile is shown:
Total cholesterol (TC) 280 mg/dL
Low-density lipoprotein (LDL)-cholesterol 210 mg/dL
High-density lipoprotein (HDL)-cholesterol 40 mg/dL
Triglycerides (TGs) 230 mg/dL
Which of the following is the mechanism of action of the best initial therapy for this patient?
assistant
Inhibition of cholesterol synthesis