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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Aorta, Blood Glucose, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Diabetic Cardiomyopathies, Disease Resistance, Drug Resistance, Endothelium, Vascular, Male, Myocardial Infarction, Myocardial Reperfusion Injury, Nitric Oxide Synthase Type III, Phosphorylation, Protein Processing, Post-Translational, Rats, Rats, Inbred Strains, Rats, Wistar, Vasoconstriction, Vasoconstrictor Agents, Vasodilation, Vasodilator Agents.
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Does mild type 2 diabetes mellitus improve remote endothelial dysfunction after acute myocardial infarction? Context: Myocardial infarction (MI) is a common cause of mortality in patients with diabetes mellitus (DM) and vascular dysfunction is a major component of diabetic cardiomyopathy. We investigated the systemic influence of acute MI on the diabetes-induced pathogenic changes in the rat aorta. Nondiabetic Wistar (W) and type-2 diabetic Goto-Kakizaki (GK) rats underwent 45min of left anterior descending coronary artery occlusion followed by 24h of reperfusion. Isometric force was measured using organ bath. Plasma glucose-levels were significantly higher in diabetic rats (GK+sham: 13±2mM; GK+MI: 19±2mM) compared to nondiabetic rats (W+sham: 8±0mM; W+MI: 8±1mM). Acetylcholine-induced relaxation was significantly weaker in rings from W+MI and GK+MI rats compared to corresponding sham-operated animals. Myocardial reperfusion injury was smaller in GK+MI than W+MI rats, and the concentration-response curves to acetylcholine were significantly enhanced in rings from GK+MI than W+MI rats. Nevertheless, the relaxation response to acetylcholine was similar in W+sham and GK+sham. Densitometric analysis of bands for endothelial nitric oxide synthase showed a significant decrease in W+MI rats compared to W+sham and GK+sham animals. Aortas from both GK+sham and GK+MI rats showed impaired contractile responses to phenylephrine in comparison with the nondiabetics.
assistant
For the first time we showed that short-term and mild type-2 DM improved remote endothelial dysfunction after reperfused acute MI. Final Decision: yes