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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Erythropoietin, Humans, Inflammation, Interleukin-6, Interleukin-8, Myocardial Ischemia, Myocardial Reperfusion Injury, Rats, Rats, Sprague-Dawley, Recombinant Proteins, Reperfusion Injury, Tumor Necrosis Factor-alpha.
user
Does recombinant human erythropoietin pretreatment attenuate heart ischemia-reperfusion injury in rats by suppressing the systemic inflammatory response? Context: Ischemia-reperfusion (I/R) injury may influence graft function after transplantation. Erythropoietin (EPO) attenuates I/R injury in various animal organs such as intestine, brain, and kidney. To evaluate the effects of pretreatment with recombinant human EPO (rhEPO) on I/R-induced heart injury. A rat model of I/R injury was established by ligating the left descending coronary artery for 30 minutes, followed by reperfusion for 4 hours. Fifty Sprague-Dawley rats were divided into 5 groups: sham operation; I/R; I/R+rhEPO, 100 U/kg; I/R+rhEPO, 1000 U/kg; and I/R+rhEPO, 5000 U/kg. Electrocardiograms were assessed continuously to note arrhythmia caused by reperfusion. Serum concentrations of interleukin (IL)-6 and IL-8, and tumor necrosis factor-alpha were measured at 2 and 4 hours after reperfusion. The rhEPO-treated animals exhibited dosage-dependent significant reduction in the incidence of ventricular arrhythmia caused by reperfusion, and markedly decreased serum concentrations of IL-6, IL-8, and tumor necrosis factor-alpha (P < .05) compared with the I/R group (P < .05).
assistant
The rhEPO attenuates myocardial I/R injury in rats, at least in part related to inhibition of the system inflammatory response. Final Decision: yes