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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, MATERIALS AND METHODS, RESULTS. Meshes: Adolescent, Adult, Antibodies, Viral, Blood Donors, Cytomegalovirus Infections, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin M, India, Male, Middle Aged, Retrospective Studies, Seroepidemiologic Studies.
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Is seroprevalence of anti-IGM CMV among blood donors relevant in India? Context: Infection with cytomegalovirus (CMV) is more common in developing nations and the people belonging to the lower socioeconomic section of the society. The immunosuppressed population for whom CMV-seronegative blood products are requested is increasing due to advances in medical care.AIM: To study the prevalence of CMV antibodies among the different sexes and age groups in healthy blood donors. A retrospective study was done on 5600 serum samples stored frozen in a repository for CMV antibodies using the ELISA technique. Five thousand three hundred and fifty (95.5%) were male and 250 (4.5%) were female. Four cases (0.071%) out of 5600 samples were positive for anti-IgM CMV with 95% Confidence Interval (95% C.I) of 0.02 - 0.17.
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In a developing country like India, screening for IgM antibody on a routine basis may not be feasible, given the likely positive yield to be low and the cost being high. It is recommended that in a tertiary care hospital, blood units to be transfused to neonates, organ transplant recipients, those suffering from malignancies and other immunocompromised patients should be screened for anti-IgM CMV or preventive strategies like universal leucodepletion to be implemented to decrease the transmission of CMV in these groups of patients.