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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Antidepressive Agents, Tricyclic, Antipsychotic Agents, Drug Therapy, Combination, Female, Humans, Male, Mianserin, Mirtazapine, Orgasm, Schizophrenia, Sexual Dysfunctions, Psychological, Treatment Outcome.
user
Does add-on mirtazapine improve orgasmic functioning in patients with schizophrenia treated with first-generation antipsychotics? Context: Sexual dysfunction, common in schizophrenia, may be further exaggerated by antipsychotics, especially those of First Generation (FGAs), and antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRs). Mirtazapine, an antidepressant characterized by its different action mechanism compared with that of the majority of other antidepressants, may improve SSRI-induced sexual dysfunction in patients with depression. It is unknown, however, whether mirtazapine improves sexual functioning in schizophrenia. This study randomly assigned FGA-treated patients with schizophrenia to receive either an add-on mirtazapine (n = 20) or a placebo (n = 19) for 6 weeks. Sexual functioning was prospectively measured using five relevant items from the Udvalg for Kliniske Undersogelser side-effect rating scale (UKU-SERS). Orgasmic function improved with statistical significance in the mirtazapine group (p = .03), with no changes in any other sexual functions in either group.
assistant
Add-on mirtazapine appears to relieve orgasmic dysfunction in FGA-treated patients with schizophrenia. Final Decision: yes