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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Allergens, Enzyme-Linked Immunosorbent Assay, Female, Fetal Blood, Food Hypersensitivity, Humans, Hypersensitivity, Immediate, Immunoglobulin A, Immunoglobulin E, Infant, Infant, Newborn, Inhalation Exposure, Pregnancy, Prenatal Exposure Delayed Effects.
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Does sensitization develop in utero? Context: Intrauterine sensitization has been suggested to play a role in the development of atopic disease in children, and this has led to current guidelines recommending allergen avoidance during pregnancy. To investigate the relevance of allergen-specific IgE in cord blood to sensitization in early infancy and the origin of such IgE. Inhalant and food allergen-specific IgE in cord blood was analyzed and compared with specific IgE in infant blood at 6 months of age and in parental blood. Cord blood IgA was measured to detect maternal blood contamination of cord blood. Allergen-specific IgE, primarily against inhalant allergens, was detected in 14% of cord blood samples. However, corresponding specific IgE was not found in infant blood at 6 months of age. Specific IgE in cord blood completely matched specific IgE in maternal blood with respect to allergen specificity, level of specific IgE, and ratio of total IgE/specific IgE. Finally, there was a correlation between specific IgE and IgA in cord blood.
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Allergen-specific IgE in cord blood does not reflect intrauterine sensitization but seems to be the result of transfer of maternal IgE to the fetus. Final Decision: no