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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which of the following is a new drug that acts by inhibiting PCSK9?
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The correct answer is  Monoclonal Antibodies that target PCSK9: Alirocumab and Evolocumab. Pro protein convease subtilisin Kexan type 9 (PCSK9) is a protein that binds LDL receptors and transpo them to lysosomes where these are degraded . Therefore instead of recycling of LDL receptor to surface of hepatocytes they get destroyed. Inhibitors of PCSK9 therefore prevent destruction of LDL receptor resulting in lowering of LDL cholesterol.