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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, DESIGN, SETTING, PATIENTS, INTERVENTIONS, MEASUREMENTS, RESULTS. Meshes: Aged, Biomarkers, Calcitonin, Calcitonin Gene-Related Peptide, Cohort Studies, Comorbidity, Emergency Service, Hospital, Extreme Heat, Female, Heat Stroke, Humans, Intensive Care Units, Male, Middle Aged, Paris, Prognosis, Protein Precursors.
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Is procalcitonin a marker of critical illness in heatstroke? Context: To study the effect of non-exertional heatstroke on serum procalcitonin (PCT) levels. Cohort study. The emergency and intensive care departments of two academic tertiary-care hospitals, Paris, France A total of 53 patients with defined heatstroke attending the emergency department and/or the intensive care unit during the August 2003 heat wave in France. None. Serum PCT measurement using a sensitive assay and vital and routine biological variables on arrival of patients presenting with classic heatstroke. Thirty-day mortality was recorded. Among the 53 patients included, 14 (26%) were admitted to an intensive care unit (ICU). At 30 days, 24 patients (45%) had died. Median PCT value was 0.58 microg/l (95% confidence interval 0.16-1.61) and 31 (58%) patients had PCT above 0.2 microg/l (PCT+). Temperature above or equal to 40 degrees C was the only variable significantly associated with fatal outcome. Median PCT values were 1.4 microg/l (0.16-4.71) and 0.18 microg/l (0.12-1.61) in the group of deceased and surviving patients respectively (p = 0.22). All patients admitted in ICU had elevated PCT values. Patients PCT+ initially presented with a more pronounced systemic inflammatory response. Microbiologically or clinically documented infection was not more frequent in PCT+ group.
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High serum PCT levels can be observed in heatstroke without any concomitant documented bacterial infection. The PCT is not a valid mortality predictor in heatstroke but could be an indicator of the severity of illness. Heatstroke could represent a model of a "non-septic" pathway of PCT synthesis.