system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Aged, 80 and over, Alleles, CARD Signaling Adaptor Proteins, Child, Child, Preschool, Cohort Studies, Colitis, Constriction, Pathologic, Crohn Disease, Digestive System Surgical Procedures, Female, Genotype, Homozygote, Humans, Ileitis, Intestinal Perforation, Male, Middle Aged, Multivariate Analysis, Neoplasm Proteins, Polymorphism, Single Nucleotide, Postoperative Complications, Prognosis, Proportional Hazards Models, Recurrence, Reoperation, Retrospective Studies, Risk Factors, Smoking, Young Adult.
user
Is cARD8 gene variant a risk factor for recurrent surgery in patients with Crohn 's disease? Context: Post-operative recurrence is frequent in Crohn's disease. Genetic factors associated with post-operative recurrence remain poorly understood. Identification of genetic variants associated with repeat surgery would allow risk stratification of patients who may benefit from early aggressive therapy and/or post-operative prophylactic treatment. Crohn's disease patients who had at least one bowel resection were retrospectively identified from the "Nancy IBD cohort". Covariates and potential interactions were assessed using the Cox proportional hazard model. Kaplan-Meier curves for time to surgical recurrence were developed for 200 genetic variants and analyzed with the log-rank test. 137 patients had at least 1 resection in our cohort: 38 had a surgical recurrence (28%). In multivariate analysis, current smoker status (OR 6.97, 95% CI 1.85-26.22, p=0.004), post-operative complications after prior surgery (OR 2.72, 95% CI 1.02-7.22, p=0.044), and Caspase recruitment domain-containing protein 8 (CARD8) homozygosity for the risk allele (OR 7.56, 95% CI 1.13-50.37, p=0.036) remained significantly and independently associated with surgical recurrence.
assistant
Current smoker status was associated with increased risk of surgical recurrence. A novel association between CARD8 and increased risk of surgical recurrence in Crohn's disease was observed. CARD8 could be a new marker for risk stratification and prevention of recurrent surgery. Final Decision: yes