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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Anemia, Anti-Inflammatory Agents, Combined Modality Therapy, Female, Ferritins, Hemoglobins, Hepcidins, Humans, Male, Middle Aged, Pentoxifylline, Renal Dialysis, Renal Insufficiency, Chronic, Treatment Outcome.
user
Does pentoxifylline alter the concentration of hepcidin in chronic kidney disease patients undergoing hemodialysis? Context: Anemia is a frequent condition in patients with chronic kidney disease due to a reduction in the production of erythropoietin. Patients with inflammation respond less well to treatment with erythropoietin, possibly because the increased production of hepcidin reduces the availability of iron for hematopoiesis. Some studies suggest that pentoxifylline has anti-inflammatory properties and could be used as adjuvant therapy in the treatment of anemia. The aim of this study was to analyze the effect of pentoxifylline on serum hepcidin in chronic hemodialysis patients with inflammation. 71 adult patients on hemodialysis with C-reactive protein (CRP) ≥0.5 mg/dl in screening tests; patients were randomized to the treatment group (oral pentoxifylline 400 mg/thrice-weekly) or the control group for 3 months follow-up. During the study, a decrease in hemoglobin, transferrin saturation, and hepcidin was observed in both groups. However, these reductions were related to the time and not to the drug. There was no difference in the concentrations of CRP, ferritin, and albumin over time in either group.
assistant
The use of this amount of pentoxifylline did not modify the serum levels of hepcidin in this population. Final Decision: no