system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Administration, Oral, Animals, Antibodies, Viral, Antigens, Viral, Capsid Proteins, Cells, Cultured, Female, Lactococcus lactis, Mice, Mice, Inbred BALB C, Recombinant Proteins, Rotavirus, Rotavirus Vaccines, Viral Proteins.
user
Does rotavirus vp7 antigen produced by Lactococcus lactis induce neutralizing antibodies in mice? Context: To determine if live recombinant Lactococcus lactis strains expressing rotavirus VP7 antigen are immunogenic in mice. Using the food-grade lactic acid bacterium L. lactis as a carrier, we expressed VP7, the major rotavirus outer shell protein and one of the main components of the infective particle, as a cytoplasmic, secreted or cell wall anchored forms. Our results showed that recombinant L. lactis strains secreting VP7 proved to be more immunogenic than strains containing the antigen in the cytoplasm or anchored to the cell wall.
assistant
This is the first demonstration that recombinant L. lactis producing VP7 can induce the production of a neutralizing antibody response against rotavirus by the intragastric route. Final Decision: yes