system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Animals, Anticholesteremic Agents, Azetidines, Cell Line, Cell Transplantation, Cholesterol, Dietary, Ezetimibe, Feces, Female, Intestinal Absorption, Intestines, Kinetics, Lipid Metabolism, Macrophages, Mice, Mice, Congenic, Mice, Inbred C57BL, Sitosterols.
user
Is cholesterol absorption from the intestine a major determinant of reverse cholesterol transport from peripheral tissue macrophages? Context: We examined the effect of ezetimibe, a cholesterol absorption (CA) inhibitor, and genetic determinants of CA on reverse cholesterol transport (RCT) from subcutaneously injected macrophages using a new dual isotope label technique. Treatment of C57BL/6J mice with ezetimibe decreased dietary CA by 86% and increased RCT from peripheral tissue macrophages (PTM) by 6-fold (P<0.0001). Moreover, congenic 14DKK mice with a modest 41% decrease in dietary CA displayed a 67% increase in RCT from PTM (P<0.007).
assistant
These findings indicate that pharmacological and genetic modifiers of cholesterol absorption are major determinants of reverse cholesterol transport from peripheral tissue macrophages. Final Decision: yes