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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which of the following is a dihydrofolate reductase inhibitor?
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The correct answer is  Methotrexate, pemetrexed and pralatrexate are the inhibitors of dihydrofolate reductase (DHFRase). These drugs also inhibit Thymidylate Synthase (TS) and the enzymes involved in early purine synthesis. Methotrexate is the drug of choice for the treatment of choriocarcinoma. Methotrexate is also indicated in the management of rheumatoid ahritis, psoriasis and ectopic pregnancy. Adverse effects of methotrexate are bone marrow suppression and mucositis.