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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Antioxidants, Asian Continental Ancestry Group, Body Composition, Catalase, DNA Damage, Dietary Supplements, Double-Blind Method, Female, Glutathione Peroxidase, Humans, Linoleic Acids, Conjugated, Lipid Peroxidation, Male, Obesity, Olive Oil, Overweight, Plant Oils, Republic of Korea, Superoxide Dismutase, Time Factors.
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Does eight weeks of conjugated linoleic acid supplementation have no effect on antioxidant status in healthy overweight/obese Korean individuals? Context: The aim of this study was to evaluate the effect of CLA supplementation on antioxidant metabolism in healthy overweight/obese Korean individuals. We performed a randomized, double-blind, placebo-controlled trial, where 29 healthy overweight/obese (BMI ≥ 23 kg/m(2)) participants (2 men and 27 women) were randomly selected to receive placebo (n = 15, 2.4 g olive oil/day) or 2.4 g/day CLA mixture (n = 14, 36.9% of cis-9, trans-11 and 37.9% of trans-10, cis-12) for 8 weeks. There were no significant differences in plasma total radical-trapping antioxidant potential (TRAP), lipid peroxidation (conjugated dienes), lipid-soluble antioxidant vitamin concentration, erythrocyte antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase) activities, and leukocyte DNA damage between the CLA and placebo groups.
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The data suggest that short-term supplementation (8 weeks) with CLA (2.4 g/day) might have no significant effects on lipid peroxidation and antioxidant metabolism. Final Decision: yes