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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
52 yrs male presented with muscular stiffness and painful cramps.The face was drawn into a forced grimace (“sardonic grin,” or risus sardonicus). Strychnine Poisoning was suspected; Strychnine is supposed to antagonizes competitively: -
assistant
The correct answer is  STRYCHNINE POISONING
Mechanism of toxicity.
Strychnine competitively antagonizes glycine, an inhibitory neurotransmitter released by post-synaptic inhibitory neurons in the spinal cord. Clinical presentation.
Muscular stiffness and painful cramps precede generalized muscle contractions and opisthotonos.
The face may be drawn into a forced grimace (“sardonic grin,” or risus sardonicus).
Repeated and prolonged muscle contractions often result in hyperthermia, rhabdomyolysis, myoglobinuria, and renal failure.
Hyperacusis, hyperalgesia, and increased visual stimulation.
Death is usually caused by respiratory arrest owing to intense contraction of the respiratory muscles.