system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Body Mass Index, Diet, Reducing, Esophagogastric Junction, Female, Follow-Up Studies, Gastroesophageal Reflux, Humans, Hydrogen-Ion Concentration, Male, Manometry, Middle Aged, Obesity, Time Factors, Weight Loss.
user
Is gastroesophageal reflux in obese patients reduced by weight reduction? Context: The present study tested the hypothesis that weight reduction improves the subjective and objective manifestations of gastroesophageal reflux. Twenty obese patients with gastroesophageal reflux as shown by 24-h pH measurement and with symptoms requiring daily medication were studied. The patients were randomized into a group (A) treated with very low-caloric diet (VLCD) and a control group (B). Objective measurements were repeated after 6 months. Group B was then treated with VLCD and reexamined. Patients in group A lost 10.8 +/- 1.4 kg whereas group B gained 0.6 +/- 0.7 kg (P < 0.001). There was no reduction in reflux according to pH measurement. Furthermore, there were no significant changes in reflux symptoms. After VLCD treatment, group B lost 9.7 +/- 1.6 kg, but reflux indicators remained unchanged. All patients except one in group B remained dependent on daily anti-reflux medication.
assistant
Weight reduction does not improve the subjective or objective manifestations of reflux. Final Decision: no