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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Adult, Biomarkers, Endothelial Growth Factors, Female, Fertilization in Vitro, Follicular Fluid, Gamete Intrafallopian Transfer, Humans, Linear Models, Lymphokines, Pregnancy, Pregnancy Rate, Retrospective Studies, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors.
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Is elevated level of follicular fluid vascular endothelial growth factor a marker of diminished pregnancy potential? Context: To evaluate whether differences in follicular fluid vascular endothelial growth factor (FF VEGF) concentrations are observed between women achieving a clinical pregnancy and those failing to conceive. Retrospective chart review and analysis of FF VEGF concentrations. University teaching center. Fifty-seven women < or =42 years of age undergoing follicular aspiration in preparation for IVF or GIFT. Analysis of FF VEGF concentrations and chart review of a single IVF or GIFT cycle. Follicular fluid VEGF concentrations, clinical pregnancy rate, age, ampules of gonadotropins used, oocytes retrieved, peak estradiol serum concentrations, day 3 FSH levels, and fertilization rate. Women who did not conceive had higher FF VEGF concentrations than women achieving a clinical pregnancy (4.409 + 2,387 versus 2.793 +/- 1,180 pg/mL: P < .001). A negative correlation was observed between FF VEGF concentrations and peak estradiol levels and number of oocytes retrieved. A positive correlation was found for FF VEGF and patient's age and ampules of gonadotropins used.
assistant
Elevated FF VEGF concentrations are associated with poor conception rates after IVF or GIFT. Final Decision: yes