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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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A patient complains of muscle weakness. It was reversed on administration of neostigmine, because:
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The correct answer is  Ans. (D) It interferes with the action of acetyl cholinesterase(Ref: Katzung 11/e p105)Neostigmine acts by inhibiting the enzyme acetylcholinesterase. This enzyme is involved in degradation of ACh, consequently neostigmine increases the synaptic level of ACh. Muscle weakness can be improved by stimulation of NM receptors at muscle end plate due to increased ACh.