system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Animals, Coronary Vessels, Ethanol, Female, Pericardium, Swine, Tunica Intima.
user
Does intrapericardial ethanol delivery inhibit neointimal proliferation after porcine coronary overstretch? Context: Previous work has shown that ethanol dampens cell growth signals and inhibits smooth muscle proliferation in a restenosis model. Catheter-based approaches to intrapericardial (IPC) delivery of therapeutic agents have been recently demonstrated to be feasible. This study tested the effect of IPC instillation of ethanol on the injury response of overstretched porcine coronary arteries. Ethanol, 30%, (E, 10 mL, n = 6) or saline, 0.9%, (C, 10 mL, n = 6) was administered IPC after overstretch injury of porcine coronary arteries. Animals were sacrificed 28 days after balloon dilation. The neointimal and adventitial area were significantly reduced in the E group (0.36 +/- 0.05 mm2; 1.68 +/- 0.09 mm2) as compared to the C group (0.61 +/- 0.05 mm2; 2.61 +/- 0.14 mm2; p < 0.001). The maximal intimal and adventitial thicknesses of the treated vessels were also significantly smaller than those of untreated vessels (0.44 +/- 0.02, 0.38 +/- 0.08 mm vs 0.57 +/- 0.03, 0.54 +/- 0.03 mm, respectively; p < 0.005). The calculated luminal stenosis decreased in the treated group, 16.1%, versus the control group, 25.3%.
assistant
Perivascular administration of a single-dose of ethanol significantly reduce neointimal proliferation in the porcine balloon-overstretch model. This data suggests that intrapericardial delivery of therapeutic agents may be useful and feasible in the coronary angioplasty setting for prevention of restenosis. Final Decision: yes