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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Carcinoma, Squamous Cell, Cell Division, Cell Movement, Extracellular Matrix, Head and Neck Neoplasms, Hepatocyte Growth Factor, Humans, Phosphorylation, Reference Values, Sensitivity and Specificity, Tumor Cells, Cultured.
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Does hepatocyte growth factor/scatter factor stimulate mitogenesis and migration of a head and neck squamous cell carcinoma cell line? Context: We sought to assess the effect of extracellular matrix and hepatocyte growth factor/scatter factor (HGF/SF) on the growth and motility of cultured squamous cell carcinoma of the head and neck (SCCHN) cells. Cultured cells were incubated in the presence of HGF/SF. The effect of HFG/SF on cell growth, motility, and phosphorylation of the signaling proteins FAK and Erk was determined. HGF/SF is both mitogenic and motogenic to the human SCCHN cell line FaDu. Incubation of FaDu cells in the presence of HGF/SF led to a rapid increase in phosphorylation of both FAK and the growth-promoting kinase Erk. HGF/SF-induced phosphorylation of FAK and Erk was observed in both detached and attached SCCHN cells. However, phosphorylation was much greater in attached cells.
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The mitogenic and motogenic activities of HGF/SF may contribute to the pathogenesis of SCCHN in vivo. Final Decision: yes