system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
The coagulation profile in a 13 year old girl with Menorrhagia having von Willebrands disease is:
assistant
The correct answer is  - Von Willebrand factor acts as a plasma carrier of factor VIII and circulates in blood as factor VIII-VWF complex. - Thus, VWF deficiency impairs intrinsic pathway of coagulation & prolongs aPTT - Extrinsic pathway of coagulation remains unimpaired, PT is not altered.