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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Bone Density, Female, Finland, Genotype, Hip Fractures, Humans, Lactase, Lactose Intolerance, Male, Polymerase Chain Reaction, Risk Factors, Wrist Injuries.
user
Does genetic variant of lactase-persistent C/T-13910 is associate with bone fractures in very old age? Context: To determine the relation between the C/T(-13910) single-nucleotide polymorphism residing 13,910 base pairs from the 5' end of the lactase gene associated with lactase persistence and the occurrence of bone fractures in elderly people. Population-based study. Vantaa 85+ population-based study, including all 601 subjects born before April 1, 1906, who were living in the city of Vantaa, Finland, on April 1, 1991. Four hundred eighty-three people aged 85 and older (106 men and 377 women). Genotype determination was made using a polymerase chain reaction minisequencing technique. The frequency of the genotype C/C(-13910) associated with adult-type hypolactasia (low lactase enzyme activity or primary lactose malabsorption (LM)) was significantly greater in individuals with hip fractures, with an adjusted odds ratio (OR) of 3.7 (95% confidence interval (CI)=1.8-7.8), wrist fractures with an adjusted OR of 2.5 (95% CI=1.2-5.2), and hip and wrist fractures combined with an adjusted OR of 4.1 (95% CI=2.0-8.3).
assistant
The C/C(-13910) genotype associated with primary LM could represent a genetic risk factor for bone fractures for elderly people. Final Decision: yes