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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Biocompatible Materials, Bone Matrix, Bone Substitutes, Carotid Arteries, Ceramics, Dose-Response Relationship, Drug, Durapatite, Epinephrine, Female, Models, Animal, Muscle Contraction, Muscle Relaxation, Muscle Tonus, Muscle, Smooth, Vascular, Papaverine, Rats, Signal Processing, Computer-Assisted, Software, Transducers, Vasoconstriction, Vasoconstrictor Agents, Vasodilation, Vasodilator Agents.
user
Is vascular smooth muscle contraction/relaxation of rat carotid artery altered by bone grafting substitutes in vitro? Context: The aim of this study was to explore the effects of various bone grafting substitutes (Osteosponge, Perioglas, Tutoplast, and Surgibone) on vascular smooth muscle tonus. Bilateral carotid arteries were removed from rats and contraction/relaxation of isolated vessel rings were measured before and after contact with the biomaterials and then, for dose-dependent epinephrine and papaverin administrations, by a force displacement transducer. The data of each biomaterial group were collected by a computerized system and corresponding software at a sample rate of 1,000 kHz and were converted to contraction force. Vascular contraction forces were influenced in response to biomaterials tested except for Osteosponge (P < 0.05), although the differences between groups were insignificant (P > 0.05). There was a dose-dependent vascular response to epinephrine and papaverine administration upon biomaterial contact (P < 0.05). The dose-dependent vascular responses to epinephrine and papaverine administration were almost similar for all biomaterials tested (P < 0.05), suggesting that the biomaterials led to reversible effects on vascular contraction/relaxation behavior, which resulted in recovery.
assistant
Osteosponge, Perioglas, Tutoplast, and Surgibone do not alter vascular smooth muscle tonus and vitality and therefore would, presumably, not jeopardize the angiogenesis of fresh blood vessels and full vascularization during tissue healing. Final Decision: no