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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Female, Forensic Pathology, Humans, Male, Middle Aged, Miotics, Ophthalmic Solutions, Pilocarpine, Postmortem Changes, Pupil, Regression Analysis, Young Adult.
user
Does the use of pilocarpine eye drop for estimating the time since death? Context: The objective of this study was to estimate the time since death using pilocarpine eye drops. In this study, 100 postmortem cases with known time of death were included. In each case, the left pupil was measured in millimeter units using a vernier caliper, and pilocarpine eye drops were applied. The pupil was measured again 10 min later, and statistical analysis was used to analyze the correlation between the time since death and the change in the pupil. The longest duration since death that the pupils showed reaction to pilocarpine was 15 h. The correlation between the change in the pupil and the postmortem interval was found (Spearman's rho, r = -0.304, p = 0.002), and the change in the pupil may be used to predict the postmortem interval by the following regression equation: postmortem interval (PMI) = 8.310-3.702 (Diff) ± 0.735 (PMI was postmortem interval in hours and Diff was the difference in the size of the pupil after administering pilocarpine in millimeter units).
assistant
The present study showed that pilocarpine eye drops can be used to estimate the time since death. Final Decision: yes