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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which of the following mutations in a tumour suppressor agent causes breast carcinoma-
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The correct answer is  Robbins and Cotran pathologic basis of disease South Asia edition. Breast cancer may be hereditary arising in women with germline mutation in tumour suppressor gene or sporadic. after a cell sustains DNA damage it must undergo cell cycle arrest and either repair its DNA or for by apoptosis by P53 . In its mutated form P53 ceases to act as a protector or as growth suppressor but instead acts like a growth promoter or onco gene..