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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which among the following factors level is not altered in vit K deficiency?
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The correct answer is  Ans b: (Factor VIII) Ref: Harrison p.367, 728-730Coagulation factors II, VII, IX, X and protein C, S and Z are dependent on Vit K for post translational modification. Vit K also for bone protein osteocalcin and vascular smooth muscle protein- matrix glaproteinFew more points:* Gamma carboxy glutamic acid residues in the Vit k dependent factors will help in their critical action including calcium and phospholipid binding* Mutations in Vit k epoxide reductase complex 1 (VKORC1) andgene encoding gamma glutamyl carboxylase(GGCX) result in defect free enzyme and there in Vit K dependent factors with decreased activity.* Causes mild to severe bleeding episodes from birth* Prolongation of PT is the most common and earliest finding in Vit K deficiency. Factor V11 has the shortest tl/2, so PT prolonged much before changes in aPTT