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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Cartilage, Articular, Cell Survival, Dinoprostone, Glycosaminoglycans, Interleukin-1, Knee Joint, Metalloendopeptidases, Methotrexate, Rabbits, Sulfasalazine.
user
Does salazosulfapyridine suppress chondrocyte mediated degradation induced by interleukin 1beta? Context: To investigate the effects of salazosulfapyridine (SASP) and methotrexate (MTX) on interleukin (IL)-1beta treated rabbit chondrocytes. Normal rabbit chondrocytes were cultured to confluency. IL-1beta was added to serum-free culture medium in the presence or absence of SASP or MTX. After 2 days' incubation, the effects were evaluated from the responses of metalloproteinases, glycosaminoglycan (GAG), and prostaglandin E2 (PGE2). SASP and MTX suppressed GAG and collagenase release into the culture medium from IL-1beta stimulated rabbit chondrocytes in a dose dependent manner. Only SASP suppressed stromelysin and PGE2 release.
assistant
SASP may have a protective effect on cartilage degradation of patients with rheumatoid arthritis. Final Decision: yes