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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, STUDY DESIGN, RESULTS. Meshes: Adolescent, Adult, Aged, Child, Female, Gene Expression Regulation, Neoplastic, Genes, erbB-2, Granulosa Cell Tumor, Humans, Middle Aged, Neoplasms, Germ Cell and Embryonal, Ovarian Neoplasms.
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Is Her-2/neu expressed in nonepithelial ovarian malignancies? Context: The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined.
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Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.