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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Case-Control Studies, Female, Humans, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Prospective Studies, Proto-Oncogene Proteins c-met, Risk Factors.
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Is plasma level of soluble c-Met tightly associated with the clinical risk of preeclampsia? Context: The objective of the study was to examine the relevance of the soluble form c-Met (sMet) with the clinical risk for severe preeclampsia. This prospective case-control study was performed by using plasma derived from 44 preeclamptic and 51 uncomplicated pregnant women. Plasma concentration of sMet was measured with specific enzyme-linked immunosorbent assay, and the predictive values were determined based on the receiver-operating characteristic (ROC) curves analysis. Plasma s-Met level in normal pregnant women changed in a gestation-dependent manner, peaking at weeks 19-24. In women with severe preeclampsia, the circulating sMet level was significantly lower than that in the gestational stage-matched controls during gestational weeks 15-30. The ROC curve analysis revealed a significant correlation between plasma sMet level and the risk of developing severe preeclampsia.
assistant
Plasma sMet could serve as a potential biomarker for predicting severe preeclampia at early second trimester of pregnancy. Final Decision: yes