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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Alanine Transaminase, Animals, Antioxidants, Aspartate Aminotransferases, Bilirubin, Disease Models, Animal, Hepatocytes, Injections, Intraperitoneal, Jaundice, Obstructive, Liver, Male, Melatonin, Pancreatitis, Acute Necrotizing, Rats, Treatment Outcome.
user
Does exogenous melatonin treatment reduce hepatocyte damage in rats with experimental acute pancreatitis? Context: The hormone melatonin affects cellular immunity in particular and the immune system in general both directly and indirectly. We report our evaluation of the effects of decreasing and increasing serum melatonin levels on hepatocyte damage in rats with experimental acute pancreatitis. Wistar Albino rats with experimentally induced acute pancreatitis were divided into three groups of ten rats each: (1) control (induced acute pancreatitis only); (2) rats with induced acute pancreatitis plus surgical pinealectomy (no melatonin injections); (3) rats with induced acute pancreatitis plus injections of exogenous melatonin. The effects of melatonin levels were evaluated using biochemical and histopathological parameters. Rats undergoing the pinealectomy had increased amylase and lactate dehydrogenase (LDH) levels, while those receiving injections of exogenous melatonin had decreased amylase, aspartate transaminase, LDH, and bilirubin levels but increased levels of alanine transferase levels.
assistant
Melatonin may have a therapeutic or protective effect on acute pancreatitis and obstructive jaundice. Final Decision: yes