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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Humans, Immunohistochemistry, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Maxillary Sinus, Middle Aged, Nasal Mucosa, Nasal Polyps, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal, Tissue Inhibitor of Metalloproteinase-1, Young Adult.
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Do nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity? Context: To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloproteinase (TIMP-1) in nasal polyposis. A case-control study. A tertiary referral center. The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosin staining were also performed and those expression levels were compared. Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group.
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The presence of AR may enhance the expression of MMP-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis. Final Decision: yes