system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 7-year-old girl presents with fatigue, jaundice, pruritus, and frequent pale stools. She developed these symptoms gradually over the past 3 months. Her past medical history is significant for multiple episodes of bronchitis and pneumonia. When asked about current respiratory symptoms, she says that she sometimes feels short of breath and has a dry, non-productive cough. Her mother was diagnosed with chronic obstructive pulmonary disease at age of 27. The girl's blood pressure is 110/80 mm Hg, the heart rate is 107/min, the respiratory rate is 18/min, and the temperature is 36.9°C (98.4°F). On physical examination, the patient is jaundiced with several petechiae over the inner surface of her upper and lower extremities. On auscultation, lung sounds are diminished and occasional wheezes are heard over the lower pulmonary lobes bilaterally. Heart auscultation reveals muffled heart sounds and no murmurs. On palpation, there is tenderness in the right upper quadrant of the abdomen and hepatomegaly. Her chest X-ray shows bilateral lower lobe emphysema. Which microscopic pathological changes are most characteristic of the patient’s condition?
assistant
Periodic acid-Schiff (PAS)-positive, diastase-resistant cytoplasmic granules in the hepatocytes