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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Angiotensin II Type 1 Receptor Blockers, Animals, Anti-Arrhythmia Agents, Antihypertensive Agents, Atrial Fibrillation, Biomarkers, Blood Pressure, Brain, Disease Models, Animal, Echocardiography, Electrocardiography, Hydralazine, Hypertension, Infusions, Intraventricular, Losartan, Male, Norepinephrine, Rats, Inbred SHR, Rats, Inbred WKY, Receptor, Angiotensin, Type 1, Sympathetic Nervous System, Time Factors.
user
Does blockade of brain angiotensin II type 1 receptor inhibit the development of atrial fibrillation in hypertensive rats? Context: Hypertension is a powerful risk factor of atrial fibrillation (AF). The pathophysiology of AF with hypertension is associated with sympathoexcitation or the renin-angiotensin system; however, current therapies cannot sufficiently prevent its development. We previously revealed that brain angiotensin II type 1 receptor (AT1R) blockade causes a depressor response via sympathoinhibition. Herein, we evaluated whether brain AT1R contributes to AF development in hypertensive rats. We divided the stroke-prone spontaneously hypertensive rats (SHRSP) treated with intracerebroventricular (ICV) infusion of vehicle, ICV infusion of losartan (S-LOS), or oral administration of hydralazine (S-HYD); and Wistar Kyoto rats treated with ICV S-VEH. Two weeks later, systolic blood pressure was significantly lower in the S-LOS group than in the S-VEH group and was even lower in the S-HYD group. Urinary norepinephrine excretion for 24h, an indirect marker of sympathoexcitation, significantly reduced in the S-LOS group but increased in the S-HYD group despite depressor response. AF was induced by transesophageal burst pacing. AF duration was significantly shorter in the S-LOS group than in the S-VEH group (5.0±0.4 vs. 15.2±3.7 s; n = 8 each; P < 0.05). However, it was significantly longer in the S-HYD group than in the S-VEH group. Interstitial atrial fibrosis and echocardiographic parameters did not differ between the SHRSP groups.
assistant
Brain AT1R blockade suppresses AF inducibility and maintenance independent of depressor response in hypertensive rats. Final Decision: yes