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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Age Factors, Aged, Aged, 80 and over, Antihypertensive Agents, Arterial Occlusive Diseases, Blood Pressure Determination, Carotid Artery Diseases, Cerebrovascular Circulation, Female, Hospitals, University, Humans, Hypertension, Male, Middle Aged, Prospective Studies, Time Factors.
user
Are age and carotid artery occlusive disease important determinants of cerebral blood flow changes after antihypertensive therapy? Context: To determine the short-term effects of antihypertensive therapy on cerebral blood flow (CBF). Prospective, observational study. A university-affiliated teaching hospital. Twenty-four patients (age range 53-85 yrs) with chronic hypertension, nine of whom had carotid artery occlusive disease (CAOD). The CBF (xenon-133 inhalation technique) and blood pressure were measured before and at 60 minutes after administration of antihypertensive therapy. Age was inversely related to the change in CBF in patients with CAOD (p < 0.01). In all patients, the change in CBF after taking antihypertensive drugs was significantly inversely associated with baseline CBF (p < 0.01). Changes in regional CBF, measured by asymmetry scores, were significantly greater in patients with CAOD than in those without CAOD (p < 0.05).
assistant
Elderly patients with occlusive extracranial cerebrovascular disease are at risk of drug-induced changes in both mean and regional CBF, and may benefit from a CBF assessment before being prescribed antihypertensive therapy. Final Decision: yes