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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Angiotensin II, Animals, Disease Models, Animal, Hypertension, Male, Mice, Mice, Knockout, Receptors, Interleukin-8B, Up-Regulation, Vascular Remodeling.
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Does genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 prevent Experimental Hypertension and Vascular Dysfunction? Context: The recruitment of leukocytes to the vascular wall is a key step in hypertension development. Chemokine receptor CXCR2 mediates inflammatory cell chemotaxis in several diseases. However, the role of CXCR2 in hypertension development and the underlying mechanisms remain unknown. Angiotensin II (490 ng·kg Angiotensin II significantly upregulated the expression of CXCR2 mRNA and protein and increased the number of CD45
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Infiltration of CXCR2 Final Decision: yes