system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 65-year-old man comes to the physician because of increasing swelling of the legs and face over the past 2 months. He has a history of diastolic heart dysfunction. The liver and spleen are palpable 4 cm below the costal margin. On physical examination, both lower limbs show significant pitting edema extending above the knees and to the pelvic area. Laboratory studies show:
Serum
Cholesterol 350 mg/dL (<200 mg/dL)
Triglycerides 290 mg/dL (35–160 mg/dL)
Calcium 8 mg/dL
Albumin 2.8 g/dL
Urea nitrogen 54 mg/dL
Creatinine 2.5 mg/dL
Urine
Blood 3+
Protein 4+
RBC 15–17/hpf
WBC 1–2/hpf
RBC casts Many
Echocardiography shows concentrically thickened ventricles with diastolic dysfunction. Skeletal survey shows no osteolytic lesions. Which of the following best explains these findings?
assistant
AL amyloidosis