system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 25-year-old female presented to the OPD with painless cervical lymphadenopathy for 2 months. On examination the lymph nodes were firm in consistency. Epitrochlear lymph nodes were also involved. There was also history of fever, night sweats and significant weight loss. A lymph node biopsy was conducted and sent for HPE examination. Flow cytometry studies were also done. Which of the following gene is involved in the above condition: -
assistant
The correct answer is  This is a case of follicular lymphoma. The normal nodal architecture is effaced It is effaced by nodular expansions of tumor cells. Nodules predominantly small lymphocytes with cleaved nuclei Also, we see larger cells with vesicular chromatin and prominent nucleoli. It is CD19, CD20, CD10 and BCL6 positive, and CD5 and CD23 negative. t(14:18) is present Mutation of BCL-2 is seen