system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 25-year-old woman first presented to your clinic due to morning stiffness, symmetrical arthralgia in her wrist joints, and fatigue. She had a blood pressure of 132/74 mm Hg and heart rate of 84/min. Physical examination revealed tenderness to palpation of both wrists but full range of motion. Anti-citrullinated protein antibodies were positive and ESR was above normal ranges. She was started on methotrexate therapy. She returns for follow up 2 months later and is found to have megaloblastic anemia. What is the mechanism of action of methotrexate?
assistant
Inhibits dihydrofolate reductase