system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Animals, Newborn, Collagenases, Disease Models, Animal, Gelatinases, Injections, Intraperitoneal, Ischemia, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Metalloendopeptidases, Mice, Mice, Inbred C57BL, Phenylalanine, Protease Inhibitors, Retina, Retinal Neovascularization, Retinal Vessels, Thiophenes, Urokinase-Type Plasminogen Activator.
user
Is retinal neovascularization suppressed with a matrix metalloproteinase inhibitor? Context: To determine the role of extracellular proteinases in ischemia-induced retinal neovascularization in an animal model and to examine the effect of proteinase inhibitors on retinal neovascularization. Retinal neovascularization was induced in newborn mice exposed to 75% oxygen for 5 days, followed by room air. Retinal extracts underwent zymographic analysis to measure the activity of urokinase and matrix metalloproteinases (MMPs). Some animals under the same conditions also received intraperitoneal injections of an MMP inhibitor. Histological analysis was done to quantitate the neovascular response in these animals. Levels of urokinase and MMPs (MMP-2 and MMP-9) in retinas were significantly increased in animals with induced retinal neovascularization. Neovascularization was significantly inhibited with intraperitoneal administration of an MMP inhibitor.
assistant
Systemic inhibition of MMPs may have therapeutic potential in preventing retinopathy associated with retinal neovascularization. Final Decision: yes