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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Atherosclerosis, Cell Adhesion Molecules, Chemokine CCL2, Double-Blind Method, Female, Humans, Inflammation, Intercellular Adhesion Molecule-1, Interleukin-18, Male, Middle Aged, Pentoxifylline, Pilot Projects, Placebos, Platelet Aggregation Inhibitors, Vascular Cell Adhesion Molecule-1.
user
Does pentoxifylline decrease serum level of adhesion molecules in atherosclerosis patients? Context: Inflammation is involved in development, progression, and complications of atherosclerotic disease. Clinical studies have indicated that the level of monocyte chemoattractant protein 1 (MCP-1), IL-18, and adhesion molecules correlates with the severity of atherosclerosis and can predict future cardiovascular events. Experimental studies have shown pentoxifylline (PTX) reduces these factors in animal models. The purpose of the present pilot study was to evaluate effect of PTX on a group of inflammatory biomarkers in patients with coronary artery disease (CAD). Forty patients with angiographically documented CAD, who fulfilled inclusion and exclusion criteria, were entered in the double-blind, randomized, pilot clinical study. The patients were randomly given PTX (400 mg three times daily) or placebo (3 tab/day) for 2 months. Serum concentrations of MCP-1, IL-18, intercellular adhesion Molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) were measured before and at the end of intervention by enzyme-linked immunosorbant assay. Our study showed that the serum levels of ICAM-1 and VCAM-1 was decreased in the study population after two-month treatment (P<0.05).
assistant
Based on the results of our pilot study, administration of PTX in CAD patients significantly decreases adhesion molecules levels. Final Decision: yes