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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Birbeck granules in the cytoplasm is seen in:
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The correct answer is  (Langerhans cells): Ref: 701-702-R, 463-HM (467-Basicpathology tfh)* The presence of Birbeck granules in the cytoplasm is characteristic of Langerhans cell histiocytosis (Tennis- rachet appearance)* As Birbeck granules are not seen in all tumours cells by electron microscopy the detection of 5-100 and CDla expression by immuno histochemical techniques aids in the diagnosis