system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Body Weights and Measures, Case-Control Studies, Child, Child, Preschool, Cystic Fibrosis, Exocrine Pancreatic Insufficiency, Female, Forced Expiratory Volume, Fractures, Bone, Humans, Male, Prevalence, Risk Assessment, Severity of Illness Index.
user
Is mild to moderate cystic fibrosis associated with increased fracture risk in children and adolescents? Context: To determine whether children and adolescents with cystic fibrosis (CF), pancreatic insufficiency (PI), and mild-to-moderate lung disease have an increased risk of fracture compared with concurrent healthy control subjects. A lifetime fracture history questionnaire was administered to 186 subjects (ages 6 to 25 years) with CF, PI and mild-to-moderate lung disease and 427 healthy white control subjects (ages 4 to 25 years). A fracture was reported by 24% of subjects with CF and 23% of healthy control subjects. Average age of first fracture was similar between the groups (8.3 years for subjects and 8.8 years for controls). The radius/ulna was the most common fracture site in both groups. Risk of fracture, adjusted for sex and age, was not greater in the CF group compared with the control group (hazard ratio: 0.96, 95% CI: 0.68, 1.30, P = .82).
assistant
Children and adolescents with CF, PI, and mild-to-moderate lung disease were not at an increased risk of fracture. Final Decision: no