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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
In a healthy patient with no renal abnormalities, several mechanisms are responsible for moving various filtered substances into and out of the tubules. Para-aminohippurate (PAH) is frequently used to estimate renal blood flow when maintained at low plasma concentrations. The following table illustrates the effect of changing plasma PAH concentrations on PAH excretion:
Plasma PAH concentration (mg/dL) Urinary PAH concentration (mg/dL)
0 0
10 60
20 120
30 150
40 180
Which of the following mechanisms best explains the decrease in PAH excretion with the increase in plasma concentration greater than 20 mg/dL?
assistant
Saturation of PAH transport carriers