system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
The type mutation that leads to replacement of valine for glutamate in sickle cell disease is
assistant
The correct answer is  Sickle-cell anemia is caused by apoint mutation in the b-globin chain of hemoglobin, causing the hydrophilic amino acid glutamic acid to be replaced with the hydrophobic amino acid valine at the sixth position. The b-globin gene is found on the sho arm of chromosome 11. Ref ganong's review of medical physiology 25e