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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Calcium, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Glucose, Hot Temperature, Hypoglycemic Agents, Insulin, Islets of Langerhans, Male, Medicine, Traditional, Panax, Plant Extracts, Rats, Rats, Sprague-Dawley.
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Does korean red ginseng stimulate insulin release from isolated rat pancreatic islets? Context: Korean red ginseng (KRG), one of heat-processed Korean ginseng (Panax ginseng C.A. Meyer), has a long history as herbal remedy for antidiabetic effect. The effect and mechanism of KRG on stimulation of insulin release were investigated in isolated rat pancreatic islets. Pancreatic islets isolated from rats were used to evaluate the insulinotropic action of KRG. The effect of Ca on the insulinotropic action of KRG was investigated. The aqueous ethanolic extract of KRG (AEE-KRG) (0.1-1.0mg/ml) significantly evoked a stimulation of insulin release at 3.3mM glucose compared to the control. Experiments at different glucose concentrations (8.4 and 16.7mM) showed that AEE-KRG significantly stimulated on its own whereas it did not potentiate insulin secretion induced by glucose. The extracellular Ca(2+)-free condition, a L-type Ca(2+) channel blocker and an ATP-sensitive K(+) channel opener significantly inhibited insulin secretion evoked by AEE-KRG.
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These findings suggest that KRG displays beneficial effects in the treatment of diabetes at least in part via the stimulation of insulin release in a glucose-independent manner. Final Decision: yes