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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Bile Acids and Salts, Case-Control Studies, Chenodeoxycholic Acid, Cholestasis, Intrahepatic, Cholic Acid, Chromatography, Liquid, Deoxycholic Acid, Female, Hispanic Americans, Humans, Male, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Reference Values, Tandem Mass Spectrometry, Young Adult.
user
Does bile acid concentration reference range in a pregnant Latina population? Context: The total bile acid (TBA) concentration criterion for diagnosing intrahepatic cholestasis of pregnancy varies in the published literature. The purpose of this study was to establish pregnancy-specific reference ranges for the TBA concentration among Latina women. Self-identified Latina women (n = 211) over 18 years of age with a singleton pregnancy were recruited and had random serum samples drawn during the second and third trimesters. The total and fractionated bile acid concentrations were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and reference ranges were calculated. Laboratory-provided general reference ranges from a general population of adult men and nonpregnant women were used for comparison. The TBA reference range for our Latina pregnant population (<8.5 µmol/L) was markedly lower than the laboratory-provided reference range (4.5 to 19.2 µmol/L).
assistant
These data suggest that the upper TBA concentration reference range in our Latina pregnant population is 8.5 µmol/L, based on LC-MS/MS measurements. Final Decision: yes