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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Circadian Rhythm, Cognition, Female, Health Status, Humans, Hydrocortisone, Male, Middle Aged, Neuropsychological Tests, Saliva, Time Factors.
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Is associations between cognitive function and naturally occurring daily cortisol during middle adulthood : timing everything? Context: We examined associations between cognitive function (CF) and the naturally occurring daily cortisol levels using data from the Midlife in the United States survey and the National Study of Daily Experiences. A national sample of 1,500 (mean age = 57 years; range = 33-84, 56% female) completed a phone-based battery of cognitive tasks and 3-6 months later provided saliva samples upon waking, 30 min after waking, at lunch time, and at bedtime on 4 consecutive days. Higher CF, particularly executive function, was associated with healthier daily cortisol profiles, including a steeper diurnal cortisol slope, higher morning cortisol levels, and lower afternoon and evening cortisol levels.
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The results indicate that better CF is associated with healthier profiles of naturally occurring cortisol and underscore the importance of the timing of cortisol sampling. Final Decision: yes