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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Aged, Analgesia, Epidural, Anesthesia, General, Blood Gas Analysis, Brain Chemistry, Female, Forced Expiratory Volume, Humans, Hypoxia, Brain, Lung, Male, Middle Aged, Oxygen Consumption, Perioperative Care, Prospective Studies, Respiration, Artificial, Respiratory Function Tests.
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Is cerebral desaturation during single-lung ventilation negatively correlated with preoperative respiratory functions? Context: To evaluate the percent change of cerebral oxygen saturation (SctO(2)) during single-lung ventilation (SLV) and its correlation with preoperative respiratory functions. A prospective, observational study. Clinical hospital. Forty patients scheduled for pulmonary lobectomy requiring one-lung ventilation for at least 1 hour under combined epidural/general anesthesia. None. SctO(2) was measured using an INVOS 5100 (Somanetics Corp, Troy, MI) before anesthesia (baseline value) and until SLV was completed. In addition, arterial blood gases (ABGs) were measured every 30 minutes. The minimum SctO(2) value during SLV was recorded and percent change from baseline calculated. The correlations with preoperative respiratory function (percent volume capacity [%VC], and percent forced expiratory volume in 1 second [FEV(1)]) and preoperative ABG levels (PaO(2) and PaCO(2)) were examined using the Pearson correlation coefficient. The level of statistical significance was set at p < 0.05. In 28 patients (70%), the minimum SctO(2) during SLV was lower than the baseline value (baseline SctO(2), 69.0% ± 9.12%; range, 53%-80%; median = 71%; minimum SctO(2), 66.6% ± 10.5%; range, 46%-89%; median, 67.5%). The percent change from baseline SctO(2) was -4.68% ± 13.5% (-21% to 32%; median, 3.5%) and was significantly negatively correlated with preoperative respiratory function (FEV(1): r = -0.482, p < 0.05; VC: r = -0.518, p < 0.05) and preoperative arterial blood PaO(2) (r = -0.351, p < 0.05).
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Greater decreases were found in SctO(2) during SLV in patients with better preoperative respiratory function. These findings suggest that intraoperative monitoring during SLV should include not only measurement of SpO(2) and PaO(2) but also SctO(2). Final Decision: yes