system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Chediak higashi syndrome, defect is-
assistant
The correct answer is  Chediak higashi syndrome -Defective phagolysosomal fusion leading to decrease in melanocytes Severe Combined Immunodeficiency- Deficiency of Purine Nucleoside Phosphorylase Chronic Mucocutaneous Candidiasis- T cell disorder leading to recurrent candidiasis X linked Hyper IgM Syndrome- Deficiency of CD40 Ligand on activated T cell