system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Alleles, Antimetabolites, Antineoplastic, Chemotherapy, Adjuvant, Chromosome Deletion, Chromosomes, Human, Pair 17, Fever, Fluorouracil, Genes, p53, Heterozygote, Humans, Point Mutation, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Radiotherapy, Adjuvant, Rectal Neoplasms, Suppositories.
user
Is p53 gene mutation directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers? Context: Several studies have recently demonstrated that apoptosis of cancer cells is triggered by diverse adjuvant cancer therapies and the induction of apoptosis correlates with the sensitivity of the primary tumor to such therapies. We investigated the factors modulating adjuvant cancer therapies by examining p53 gene mutations and chromosome 17p allelic losses in 15 rectal cancers treated by a preoperative combined therapy consisting of radiation, intraluminal hyperthermia and 5-fluorouracil suppositories. The point mutations were detected in 7 of 15 (46.7%) tumors by single-stranded conformational polymorphism and direct sequencing. Allelic losses at chromosome 17p were also detected in 7 of 15 (46.7%) tumors by dinucleotide-repeat polymorphisms. There was no correlation between p53 gene abnormalities and the preoperative tumoricidal effect of the therapy.
assistant
We conclude that p53 gene abnormalities do not directly increase resistance to the combined adjuvant therapy. Final Decision: no