system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Child, Preschool, Female, Humans, Infant, Inhalation, Intensive Care Units, Pediatric, Male, Prospective Studies, Respiration, Artificial, Respiratory Function Tests, Respiratory Mechanics, Statistics, Nonparametric, Work of Breathing.
user
Is inspiratory work of breathing decreased by flow-triggered sensing during spontaneous breathing in children receiving mechanical ventilation : a preliminary report? Context: To determine the effect of pressure-trigger (PT) and flow-trigger (FT) sensing on the work of breathing (WOB) during spontaneous, unsupported breathing in children receiving mechanical ventilation. Prospective clinical trial. Pediatric intensive care unit at a tertiary care children's hospital. Infants and children receiving mechanical ventilation for >24 hrs who were ready for extubation. During synchronized mandatory ventilation, WOB values for spontaneous, unsupported, non-synchronized mandatory ventilation patient breaths were measured using an esophageal balloon and FT or PT sensing on Servo 300 and PT sensing on Servo 900C ventilators assigned in random order. Sixteen patients with a median age of 12.8 mos (25th-75th quartile [IQR], 8.1-38.2 mos), weight of 11.0 kg (IQR, 8.9-18.8 kg), and duration of mechanical ventilation of 7.5 days (IQR, 5.0-18.0 days) participated in the study. WOB for patient breaths using the Servo 300 FT sensing (0.8 J/L [IQR, 0.5-1.0]) was not significantly lower than WOB for PT sensing on Servo 300 (0.9 J/L [IQR, 0.4-1.3 J/L]) or the Servo 900C (0.9 J/L [IQR, 0.5-1.3 J/L]). However, when lung compliance was <0.75 mL.kg(-1).cm H(2)O(-1), WOB using the Servo 300 FT sensing (0.8 J/L [IQR, 0.6-1.1 J/L]) mechanism was significantly lower than those for PT sensing on both the Servo 300 (1.1 J/L [IQR, 0.9-1.3 J/L]) and Servo 900C (1.2 J/L [IQR, 1.1-1.5 J/L]) ventilators (p </=.017).
assistant
FT may not decrease WOB compared with PT for unsupported spontaneous breathing in children receiving mechanical ventilation. However, when lung compliance is decreased, FT sensing may be advantageous in decreasing the WOB. Final Decision: no