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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Alanine, Algorithms, Animals, Biomarkers, Tumor, Carbon Isotopes, Computer Simulation, Lactic Acid, Liver Neoplasms, Magnetic Resonance Spectroscopy, Mice, Mice, Transgenic, Models, Biological, Pyruvic Acid, Reproducibility of Results, Sensitivity and Specificity.
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Do quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS? Context: Magnetic resonance spectroscopy of hyperpolarized substrates allows for the observation of label exchange catalyzed by enzymes providing a powerful tool to investigate tissue metabolism and potentially kinetics in vivo. However, the accuracy of current methods to calculate kinetic parameters has been limited by T1 relaxation effects, extracellular signal contributions, and reduced precision at lower signal-to-noise ratio. To address these challenges, we investigated a new modeling technique using metabolic activity decomposition-stimulated echo acquisition mode. The metabolic activity decomposition-stimulated echo acquisition mode technique separates exchanging from nonexchanging metabolites providing twice the information as conventional techniques. This allowed for accurate measurements of rates of conversion and of multiple T1 values simultaneously using a single acquisition.
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The additional measurement of T1 values for the reaction metabolites provides further biological information about the cellular environment of the metabolites. The new technique was investigated through simulations and in vivo studies of transgenic mouse models of cancer demonstrating improved assessments of kinetic rate constants and new T1 relaxation value measurements for hyperpolarized (13) C-pyruvate, (13) C-lactate, and (13) C-alanine. Final Decision: yes