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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, BACKGROUND, METHODS, RESULTS. Meshes: Acute Coronary Syndrome, Age Factors, Aged, Atherosclerosis, Biomarkers, C-Reactive Protein, Coronary Angiography, Coronary Artery Disease, Erythrocytes, Follow-Up Studies, Glomerular Filtration Rate, Heart Failure, Hemoglobins, Humans, Interleukin-8, Kaplan-Meier Estimate, Male, Middle Aged, Mortality, Multivariate Analysis, Myocardial Infarction, Natriuretic Peptide, Brain, Peptide Fragments, Prognosis, Prospective Studies, Renal Insufficiency.
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Are elevated baseline plasma IL-8 levels an independent predictor of long-term all-cause mortality in patients with acute coronary syndrome? Context: To investigate the long-term prognostic significance of baseline plasma IL-8 levels in a group of well-characterized male patients presenting with acute coronary syndrome. IL-8 is a cytokine that has been implicated in the pathogenesis of atherosclerosis and acute coronary syndrome. Elevated plasma levels have been reported in patients with acute coronary syndrome. Baseline plasma IL-8 levels were measured in 180 male patients with acute coronary syndrome who were referred for coronary angiography and followed prospectively for the development of all-cause mortality for 5 years. In a multivariate model that included a wide variety of baseline clinical, laboratory and angiographic parameters in the selection process, baseline plasma IL-8 levels (analyzed as a continuous variable) emerged as a significant predictor of all-cause mortality at 5 years (HR, 1.43; 95% CI, 1.08-1.88; p = 0.0123). Furthermore, in 3 additional multivariate models that also included in the selection process a number of contemporary biomarkers with established prognostic efficacy in ACS (i.e., NT-proBNP, hs-CRP, hemoglobin and RDW), IL-8 remained an independent predictor of all-cause mortality at 5 years.
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Elevated baseline plasma levels of IL-8 are associated with an increased risk of long-term all-cause mortality in patients with acute coronary syndrome. Furthermore, this association is independent of a variety of clinical, laboratory and angiographic variables, including contemporary biomarkers with established prognostic efficacy in acute coronary syndrome. Final Decision: yes