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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Blood Glucose, Diabetes Mellitus, Drug Administration Schedule, Female, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Male, Middle Aged, Nursing Homes.
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Can diabetes medication be reduced in elderly patients? Context: HbA1c was measured in 98 patients with known diabetes in 17 nursing homes in Sweden. Thirty-two subjects with HbA1c<or=6.0% participated in the drug withdrawal study. After measuring plasma glucose on 3 consecutive days, diabetes drugs were reduced, i.e. complete withdrawal of oral anti-diabetic drugs (OADs), complete insulin withdrawal when doses were<or=20units/day and reduced by half in patients on more than 20units/day. We identified 31 episodes of plasma glucose<or=4.4mmol/l, most of them nocturnal (n=17). Mean HbA1c was 5.2+/-0.4% compared to 7.1+/-1.6% in the non-intervention group. Three months after the diabetes drug discontinuation, 24 patients (75%) remained in the intervention group and mean HbA1c was then 5.8.+/-0.9%. Six months after baseline investigation mean HbA1c in the intervention group was 5.8+/-1.1% compared with 6.6+/-1.4% in the non-intervention group.
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Hypoglycaemic events are common among elderly patients with type 2 diabetes. The withdrawal of diabetes medication in elderly with tight glycaemic control is safe and may decrease the risk for hypoglycaemia.