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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aromatase, Estradiol, Female, Follicle Stimulating Hormone, Gene Frequency, Genetic Association Studies, Gonadotropins, Homozygote, Humans, Luteinizing Hormone, Microsatellite Repeats, Oocytes, Ovarian Follicle, Ovary, Polymorphism, Genetic, Reproductive Techniques, Assisted.
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Do aromatase ( CYP19 ) gene variants influence ovarian response to standard gonadotrophin stimulation? Context: The association of cytochrome P450 aromatase gene CYP19(TTTA)                            (                               n                            ) polymorphism with ovarian response to FSH stimulation was explored. Three hundred women undergoing medically assisted reproduction and 300 women with at least one spontaneous pregnancy participated in the study. CYP19(TTTA)                            (                               n                            ) polymorphism was genotyped, while serum hormones were determined. During oocyte retrieval, the follicular size, the follicle and oocyte numbers were recorded. Six CYP19(TTTA)                            (                               n                            ) alleles with 7 to 12 repeats were revealed. Women homozygous for long CYP19(TTTA)                            (                               n                            ) alleles presented with lower serum FSH levels at the third day of the menstrual cycle (p < 0.001) and higher large follicle numbers (p < 0.01), compared to women homozygous for short CYP19(TTTA)                            (                               n                            ) alleles. The CYP19(TTTA)                            (                               7                            ) allele was associated with higher serum FSH levels (p < 0.003), with lower total follicle (p < 0.02) and large follicle numbers (p < 0.03), while CYP19(TTTA)                            (                               7                            ) allele-carriers presented more frequently with small follicles than CYP19(TTTA)                            (                               7                            ) allele-non carriers (p < 0.01).
assistant
CYP19 genetic variants were associated with ovarian reserve and response to standard gonadotrophin stimulation of women undergoing in vitro fertilization. Final Decision: yes