system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Treatment for methotrexate poisoning
assistant
The correct answer is  Methotrexate poisoning: The toxicity of Mtx cannot be overcome by folic acid, because it will not be conveed to the active coenzyme form(due to inhibition of DHFA reductase by Mtx) Treatment:- Folinic acid (N5 formyl THFA, cirovorum factor) rapidly reverses the effects. Thymidine also counteracts Mtx toxicity. Ref:- kd tripathi; pg num:- 862