system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Allografts, Animals, Biomimetic Materials, Cells, Immobilized, Diabetes Mellitus, Experimental, Diabetic Angiopathies, Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Mice, Neovascularization, Physiologic, Tissue Scaffolds, Vascular Endothelial Growth Factor A.
user
Does delivery of mesenchymal stem cells in biomimetic engineered scaffolds promote healing of diabetic ulcers? Context: We hypothesized that delivery of mesenchymal stem cells (MSCs) in a biomimetic collagen scaffold improves wound healing in a diabetic mouse model. Rolled collagen scaffolds containing MSCs were implanted or applied topically to diabetic C57BL/6 mice with excisional wounds. Rolled scaffolds were hypoxic, inducing MSC synthesis and secretion of VEGF. Diabetic mice with wounds treated with rolled scaffolds containing MSCs showed increased healing compared with controls. Histologic examination showed increased cellular proliferation, increased VEGF expression and capillary density, and increased numbers of macrophages, fibroblasts and smooth muscle cells. Addition of laminin to the collagen scaffold enhanced these effects.
assistant
Activated MSCs delivered in a biomimetic-collagen scaffold enhanced wound healing in a translationally relevant diabetic mouse model. Final Decision: yes