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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: 2-Pyridinylmethylsulfinylbenzimidazoles, Adult, Amoxicillin, Anti-Bacterial Agents, Anti-Infective Agents, Anti-Ulcer Agents, Antibody Specificity, Aryl Hydrocarbon Hydroxylases, Clarithromycin, Cytochrome P-450 CYP2C19, Drug Resistance, Multiple, Bacterial, Drug Therapy, Combination, Endoscopy, Gastrointestinal, Female, Gastritis, Genetic Predisposition to Disease, Genotype, Helicobacter Infections, Helicobacter pylori, Humans, Interleukin-1, Lansoprazole, Male, Middle Aged, Mixed Function Oxygenases, Mutation, Omeprazole, Patient Compliance, Peptic Ulcer, Polymorphism, Genetic, Proton Pump Inhibitors, Proton Pumps, Treatment Outcome.
user
Does polymorphism of interleukin-1beta affect the eradication rates of Helicobacter pylori by triple therapy? Context: Polymorphism in interleukin-1beta (IL-1beta) is associated with intragastric pH levels in Helicobacter pylori-positive subjects. Intragastric pH levels affect the activity of antibiotics against H. pylori in the stomach. The aim of this study was to investigate whether IL-1beta polymorphism is associated with eradication rates of H. pylori by triple therapy with a proton pump inhibitor (PPI), amoxicillin, and clarithromycin. Three hundred thirty-six patients infected with H. pylori completed treatment with omeprazole, 20 mg, or lansoprazole, 30 mg twice daily; clarithromycin, 200 mg 3 times daily; and amoxicillin, 500 mg 3 times daily, for 1 week. IL-1beta-511 and CYP2C19 genotypes of patients and sensitivity of H. pylori to clarithromycin and amoxicillin were determined. Logistic regression analysis showed that the IL-1beta-511 polymorphism, as well as CYP2C19 genotype of patients and clarithromycin-resistance of H. pylori, was associated with successful eradication. Eradication rates for H. pylori were 77.3% (75 of 97; 95% confidence interval, 67.5-84.6), 89.6% (147 of 164; 95% confidence interval, 83.9-93.1), and 94.7% (95% confidence interval, 86.9-98.5) in patients with the C/C, C/T, and T/T genotypes of IL-1beta-511, respectively (P = 0.0014).
assistant
IL-1beta-511 polymorphism is one of the determinants of successful eradication of H. pylori using triple therapy with a PPI, amoxicillin, and clarithromycin, together with CYP2C19 genotype and bacterial resistance to clarithromycin. Final Decision: yes