system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Refsum's disease is due to deficiency of which of the following enzyme?
assistant
The correct answer is  Phytanic alpha oxidase 

Refsum disease is caused by a deficiency of phytanic acid α -hydroxylase (α -oxidase) which is required for a-oxidation of methylated fatty acids, phytanic acid.