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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A young woman with ataxia-telangiectasia syndrome.For each patient with a medical condition, select the most likely immune dysfunction.
assistant
The correct answer is  Ataxia-telangiectasia and both T- and B-cell dysfunction.Multiple myeloma and chronic lymphocytic leukemia are two of the more common causes of B-cell deficiency/dysfunction. Hodgkin's disease, AIDS, sarcoidosis, and thymic aplasia or hypoplasia result in T-lymphocyte depletion/dysfunction. SLE has been associated with C3 deficiency, but most severe complement deficiencies result from inherited disorders. Ataxia telangiectasia, common variable hypogammaglobulinemia, severe combined immunodeficiency, and Wiskott-Aldrich syndrome have mixed T- and B-cell deficiency.