system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Dystroglycans, Extraembryonic Membranes, Female, Fetal Membranes, Premature Rupture, Gestational Age, Humans, Labor, Obstetric, Obstetric Labor, Premature, Pregnancy.
user
Does dystroglycan in human fetal membranes decrease in later gestation and with spontaneous membrane rupture? Context: The transmembrane protein dystroglycan (DG) is known to anchor the cell membrane to the extracellular matrix, and is susceptible to cleavage by matrix metalloproteinases. This study tested the hypothesis that changes in DG abundance in fetal membranes (FM) occur late in gestation, with spontaneous rupture of membranes (SROM), and during labor. FM were collected from a prospective cohort consisting of four groups of patients (term labor, term unlabored, preterm labor, and preterm unlabored). FM were subjected to immunohistochemical staining using antibodies specific for α- and β-DG subunits, and staining intensity was graded by a blinded pathologist. α- and β-DG staining was significantly decreased at term and after SROM (p < 0.05), but not in the presence of labor.
assistant
Decreased DG intensity was seen in FM of patients at term and with SROM, but no change was observed with labor. Final Decision: yes