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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antigens, CD34, Carcinoma, Non-Small-Cell Lung, Disease Progression, Endothelial Growth Factors, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Lung Neoplasms, Lymphokines, Male, Middle Aged, Neoplasm Staging, Neovascularization, Pathologic, Prognosis, Survival Analysis, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors.
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Is high vascularity in the peripheral region of non-small cell lung cancer tissue associated with tumor progression? Context: We attempted to determine if the degree of angiogenesis can serve as a prognostic factor in the case of completely resected non-small cell lung cancer patients, with special reference to the center and the periphery of the tumor tissue. For 255 Japanese patients who underwent completely resected non-small cell lung cancer (NSCLC), micro vessel density (MVD) was assessed by visual quantification of microvessels immunostained with anti-CD34 monoclonal antibody in 5 m section. Vascular endothelial growth factor (VEGF) was also immunostained on the same paraffin block specimen. MVD at the center (MVD-c) and that at the periphery (MVD-p) were frequently different in each individual although a weak positive correlation was observed (r=0.499, P<0.0001). One hundred and one patients with high MVD-p, but not the 107 patients with high MVD-c, showed a significantly higher proportion of advanced stage, larger tumor size and nodal metastasis as compared with MVD. The 5 year survival rate and median survival time for the high MVD-p group were significantly lower than that of low the MVD-p group (43.0%/31 months vs 48.6%/54 months, P=0.0256). As to the relationship among vascular endothelial growth factor (VEGF) and MVD, expression of VEGF was not associated with the degree of MVD. However, patients with high grade MVD-p showed an unfavorable prognosis in cases of high expression of VEGF.
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High MVD-p is associated with advancement of NSCLC, and it was particularly apparent in conjunction with high VEGF expression. Final Decision: yes