system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Biopsy, Disease Progression, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Grading, Neoplasm Staging, Preoperative Period, Prostatectomy, Prostatic Neoplasms, Receptors, G-Protein-Coupled, Retrospective Studies.
user
Is urotensin II receptor on preoperative biopsy associated with upstaging and upgrading in prostate cancer? Context: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients. A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry. A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55-68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23-100.48).
assistant
UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients. Final Decision: yes