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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Endothelial derived relaxing factor is associated with
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The correct answer is  Ref Robbins 8/p60;7/e,72-73 ;9/e p80 , it is firmly established this substance is nitric oxide (NO).Endothelium produces NO which then diffuses to the vascular smooth muscle tissue, although these seems to be evidence that vasodilatory may also be of neuronal origin, rather than endothelial. NO is produced by the enzyme nitric oxide synthase and it relaxes smooth muscle tissue by promotig the synthesis of cGMP.