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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Type I hypersensitivity is mediated by which of the following immunoglobulins?
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The correct answer is  Type I hypersensitivity reaction is IgE dependent. Cytotoxic IgE antibodies are fixed on the surface of tissue cells ( mast cells and basophils) in sensitized individuals. The antigen combines with the cell fixed antibody, leading to release of pharmacologically active substance that produces the clinical reaction. Reference : Anathanarayan & paniker's 9th edition, pg: 162 <\p>