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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Aging, Cardiovascular Diseases, Case-Control Studies, Cause of Death, Female, Gait, Geriatric Assessment, Humans, Longitudinal Studies, Male, Mental Status Schedule, Movement Disorders, Netherlands, Proportional Hazards Models, Risk Factors, Surveys and Questionnaires, Survival Analysis.
user
Are idiopathic senile gait disorders signs of subclinical disease? Context: To evaluate survival and causes of death in subjects with idiopathic senile gait disorders. A population-based longitudinal study. Survival analysis of the oldest old within the Leiden 85-plus Study. We distinguished three different groups according to their gait: subjects with a normal gait (n = 25), subjects with senile gait disorders (n = 14), and subjects with gait disorders due to known disease (n = 87). The mean age was 90 years in all groups (range 87 to 97 years). The risk of all cause mortality and cardiovascular mortality was estimated over 5 years of follow-up in a Cox-proportional hazards model, adjusted for age and sex. Eighty-nine of 126 subjects died during follow-up. Mean survival differed among the three groups (P log-rank = .01). All cause mortality risk was increased in subjects with senile gait disorders compared with subjects with a normal gait (RR = 2.8; 95% CI, 1.1-7.3, P = .03) and was similar to subjects with gait disorders caused by known disease (RR = 1.2; 95% CI: .6-2.5, P = .6). Mortality caused by cardiovascular disease also differed among the three groups (P log-rank = .03). The risk of cardiovascular death in subjects with senile gait disorders was twofold greater than in subjects with a normal gait (RR = 2.1; 95% CI, 0.4-10.3).
assistant
Senile gait disorders are related to subclinical, perhaps cardiovascular, disease. Senile gait disorders should not be accepted as an inevitable, benign concomitant of the normal aging process. Final Decision: yes