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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
All of the following are false regarding vascular leakage in acute inflammation, except:
assistant
The correct answer is  Several mechanisms are responsible for the increased permeability of postcapillary venules, a hallmark of acute inflammation. Chemical mediators such as histamine, bradykinin, leukotrienes, elicit endothelial cell contraction which is the immediate transient response. This results in increased interendothelial spaces - the most common mechanism of vascular leakage. In most instances, leakage stas immediately after injury and is sustained for several hours until the damaged vessels are thrombosed or repaired. Increased transpo of fluids and proteins through the endothelial cell, called transcytosis, also contributes to vascular leakage.