system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Cholecystokinin, Eating, Gastrectomy, Male, Rats, Rats, Sprague-Dawley, Weight Loss.
user
Is cholecystokinin partly responsible for reduced food intake and body weight loss after total gastrectomy in rats? Context: To determine the cause of body weight loss after total gastrectomy. We evaluated the acute effect of exogenous cholecystokinin (CCK) on food intake and the chronic effect of CCK receptor blockade on food intake and body weight after total gastrectomy in rats. Exogenous CCK significantly reduced food intake in gastrectomized rats; this was blocked by administration of a CCK-A but not a CCK-B receptor antagonist. Chronic treatment with a CCK-A or CCK-B receptor antagonist after total gastrectomy in rats significantly increased postoperative food intake and body weight.
assistant
Our data indicate that endogenous CCK is partly responsible for reduced food intake and body weight loss after total gastrectomy in rats. Final Decision: yes