system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Animals, Cells, Cultured, Dermatitis, Fibroblasts, Humans, Hyperplasia, Keratinocytes, Leukocytes, Male, Mice, Inbred C57BL, Nanodiamonds, Radiation-Protective Agents, Radiodermatitis, Skin, Titanium, Ultraviolet Rays, Zinc Oxide.
user
Do nanodiamonds protect skin from ultraviolet B-induced damage in mice? Context: Solar ultraviolet (UV) radiation causes various deleterious effects, and UV blockage is recommended for avoiding sunburn. Nanosized titanium dioxide and zinc oxide offer effective protection and enhance cosmetic appearance but entail health concerns regarding their photocatalytic activity, which generates reactive oxygen species. These concerns are absent in nanodiamonds (NDs). Among the UV wavelengths in sunlight, UVB irradiation primarily threatens human health. The efficacy and safety of NDs in UVB protection were evaluated using cell cultures and mouse models. We determined that 2 mg/cm(2) of NDs efficiently reduced over 95% of UVB radiation. Direct UVB exposure caused cell death of cultured keratinocyte, fibroblasts and skin damage in mice. By contrast, ND-shielding significantly protected the aforementioned pathogenic alterations in both cell cultures and mouse models.
assistant
NDs are feasible and safe materials for preventing UVB-induced skin damage. Final Decision: yes