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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adenoviridae, Animals, Cell Division, Collagen, Colorectal Neoplasms, Disease Models, Animal, Endostatins, Endothelium, Vascular, Genetic Therapy, Genetic Vectors, Liver Neoplasms, Mice, Mice, Inbred BALB C, Neoplasm Metastasis, Neoplasm Transplantation, Peptide Fragments, Transduction, Genetic.
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Does [ Adenoviral transduction of endostatin gene prevent the liver metastasis of colorectal carcinoma in postoperation ]? Context: To study the prevention of colorectal cancer liver metastasis by adenoviral transduction of the endostatin gene. The recombinant adenovirus expressing endostatin was constructed. Its biological activities were surveyed in vitro, as determined in human umbilicus vein endothelium cell (HUVEC) proliferation inhibition, and in vivo, by reduction of liver metastasis. HUVEC proliferation was obviously inhibited by the infecting supernatant of recombinant adenovirus. Persistent high serum levels of endostatin in peripheral blood, especially in the liver vein were observed. The production of liver metastasis was intervened.
assistant
The single injection in the vein of the recombinant adenovirus realizes the high effective and stable expression of endostatin in general body and liver, which brings about the ideal prevention of liver metastasis. Final Decision: yes