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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Adult, Bicycling, Biomarkers, CD40 Ligand, Cardiovascular Diseases, Cross-Over Studies, Exercise, Humans, Jogging, Male, Risk Factors, Sports.
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Is the cardiovascular risk factor , soluble CD40 ligand ( CD154 ) , but not soluble CD40 lowered by ultra-endurance exercise in athletes? Context: Soluble CD40 ligand (sCD40L) is a powerful marker of cardiovascular risk. Exercise is known to decrease cardiovascular risk, but the impact of ultra-endurance exercise on sCD40L responses is unknown. To examine the relationship between ultra-endurance exercise in trained athletes and levels of sCD40L and its natural ligand sCD40. Control-trial, crossover design, exercise intervention study of sCD40L and sCD40 levels. Outdoor exercise and laboratory testing, single centre study, School of Physical Education, University of Otago, New Zealand. Nine trained ultra-endurance athletes. Athletes exercised (cycled and jogged) for 17 of 24 h. Venous blood was sampled at baseline and serially throughout exercise and 24 and 48 h after exercise. The athletes completed a 24 h control trial on a separate occasion, in randomised order. Mean levels of sCD40L and sCD40 during exercise and rest with 95% CIs. sCD40L levels dropped steadily from baseline (median 4128 pg/ml) to a measured nadir at 24 h following exercise (median 1409 pg/ml) (p=0.01). The levels had started to rise again by 48 h after exercise. When measured as a group, sCD40L levels remained constant during a control rest period. sCD40 levels remained constant on both exercise and control days.
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Ultra-endurance exercise lowers the levels of the cardiovascular risk marker sCD40L in athletes. These results raise the possibility that exercise-induced changes in sCD40L may provide one of the mechanisms by which exercise lowers cardiovascular risk. Final Decision: yes