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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adaptation, Physiological, Adaptation, Psychological, Aged, Aged, 80 and over, Double-Blind Method, Female, Functional Laterality, Humans, Lenses, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Parietal Lobe, Perceptual Disorders, Random Allocation, Stroke, Transcranial Direct Current Stimulation, Treatment Outcome.
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Does a-tDCS on the ipsilesional parietal cortex boost the effects of prism adaptation treatment in neglect? Context: The aim of the study is to compare the effects of multiple sessions of cathodal (c-tDCS) or anodal tDCS (a-tDCS) in modulating the beneficial effects of prism adaptation (PA) treatment in neglect patients. 30 neglect patients were submitted to 10 daily sessions of PA treatment. Patients were pseudo-randomly divided into 3 groups. In the c-tDCS-group, each PA session was coupled with 20 minutes of cathodal stimulation of the left, intact PPC; in the a-tDCS-group, anodal stimulation was applied to PPC of the damaged hemisphere; in the Sham group, sham stimulation was applied. Neglect was evaluated before and after treatment with the Behavioral Inattention Test. Combined tDCS-PA treatment induced stronger neglect improvement in the a-tDCSgroup as compared to the Sham group. No improvement was found in the c-tDCS group, with respect to that normally induced by PA and found in the Sham group.
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c-tDCS abolished neglect amelioration after PA, possibly because stimulation affected the sensorimotor network controlling prism adaptation. Instead, a-tDCS PPC boosted neglect amelioration after PA probably thanks to increased excitability of residual tissue in the lesioned hemisphere, which in turn might reduce dysfunctional over-excitability of the intact hemisphere. Final Decision: yes