system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A one year old child having leucocoria was detected to be having a unilateral, large retinoblastoma filling half the globe. Current therapy would involve-
assistant
The correct answer is  *Tumor involving less than half of the globe- Multimodal therapy (chemoreduction followed by local destruction). *Tumor involving half or more of the globe - Enucleation. Ref: Wills Eye hospital at las of Clinical ophthalmology p.269.