system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: 2-Pyridinylmethylsulfinylbenzimidazoles, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Benzimidazoles, Clarithromycin, Double-Blind Method, Drug Therapy, Combination, Dyspepsia, Enzyme Inhibitors, Female, Fish Oils, Helicobacter Infections, Helicobacter pylori, Humans, Male, Metronidazole, Middle Aged, Omeprazole, Pantoprazole, Sulfoxides, Treatment Outcome.
user
Is fish oil ( Eicosapen ) less effective than metronidazole , in combination with pantoprazole and clarithromycin , for Helicobacter pylori eradication? Context: In vitro omega-3-fatty acids (Eicosapen) are bacteriostatic to Helicobacter pylori and have a variety of immuno-modulating effects. To investigate the efficacy and tolerability of eicosapen (E) as an antibiotic-sparing component of a triple H. pylori eradication regimen in non-ulcer dyspepsia patients in a randomized, double-blind trial. Non-ulcer dyspepsia patients (n=199), with a normal upper endoscopy and a positive (13)C-urea breath test (UBT) were randomly assigned to either pantoprazole, clarithromycin and metronidazole (PCM) or pantoprazole, clarithromycin and eicosapen (PCE) for 7 days. Four weeks after treatment, H. pylori eradication was determined by UBT. Symptoms were followed up to 16 months. In the intention-to-treat population, PCM eradicated infection in 78% but PCE was successful in only 34% (P < 0.001). Symptomatic improvement occurred in both groups, and was not related to H. pylori eradication.
assistant
Eicosapen is unlikely to be useful in H. pylori eradication regimens. Final Decision: yes