system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Testing, Humans, Logistic Models, Male, Mauritania, Middle Aged, Multivariate Analysis, Odds Ratio, Phenotype, Polymorphism, Single Nucleotide, Potassium Channels, Inwardly Rectifying, Risk Factors.
user
Is e23K variant in KCNJ11 gene associated with susceptibility to type 2 diabetes in the Mauritanian population? Context: Many genetic association studies reported the contribution of KCNJ11 gene to type 2 diabetes susceptibility in different populations. We aimed to evaluate the association between E23K variant of KCNJ11 and type 2 diabetes in the Mauritanian population. We performed a case-control association study including 135 type 2 diabetes Mauritanian patients and 135 controls. Genotyping for the E23K variant was performed using a TaqMan allelic discrimination assay. We found significant association between KCNJ11 E23K variant and type 2 diabetes (Global model, OR=2.08, 95% CI=1.09-3.97, p=0.026). In the Moor ethnic group, E23K was also associated with type 2 diabetes in the general model (OR=2.08, 95% CI=1.09-3.97, p=0.026) and under the dominant model (OR=2.49, 95% CI=1.12-5.55, p=0.026). In the Mauritanians of African descent, KK genotype was not found. Besides, E23K variant was not associated with type 2 diabetes (OR=0.69, 95% CI=0.04-11.32, p=0.793).
assistant
Our results revealed the risk of type 2 diabetes conferred by KCNJ11 E23K gene variant in the Mauritanian population. Final Decision: yes