system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Creatinine, Cystatin C, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Primary Health Care, Renal Insufficiency, Chronic, Young Adult.
user
Is the age related association more pronounced for cystatin C estimated GFR than for creatinine estimated GFR in primary care patients? Context: There is an age associated change in GFR but this association may be influenced by the method used. The aims of the present study were to assess the association between age and cystatin C and creatinine based glomerular filtration rate estimates in primary care patients, and to determine the proportion of patients with clinically important renal impairment. 1552 samples with simultaneous requests for creatinine and cystatin C from 1552 primary care patients in the county of Uppsala, Sweden were analysed. MDRD, CKD-EPI and cystatin C equations were used to calculate glomerular filtration rate (GFR) and the associations between GFR and age were explored. The yearly change in cystatin C estimated GFR was 1.24 mL/min/1.73 m(2) while the corresponding decline for creatinine estimated GFR was 0.76 mL/min/1.73 m(2) for MDRD and 0.99 mL/min/1.73 m(2) for CKD-EPI.
assistant
The age related association with GFR estimates is smaller for creatinine estimates than for cystatin C estimates. This leads to differences in the number of patients with reduced eGFR detected with the three estimates and the patient treatment will depend on the estimate used. This is not coherent with a good patient care and we thus need to develop new eGFR equations with better agreement between the estimates. Final Decision: yes