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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, CD28 Antigens, CD4-Positive T-Lymphocytes, CD57 Antigens, CD8-Positive T-Lymphocytes, Child, Female, Granzymes, Humans, Immunologic Memory, Immunophenotyping, Interferon-gamma, Interleukin-4, Leukocyte Common Antigens, Male, Membrane Glycoproteins, Pars Planitis, Perforin, Pore Forming Cytotoxic Proteins, Receptors, CCR7, Receptors, Chemokine, T-Lymphocytes, Tumor Necrosis Factor Receptor Superfamily, Member 7.
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Is pars planitis associated with an increased frequency of effector-memory CD57+ T cells? Context: To evaluate the frequency, phenotype and the potential function of CD57+ T cell subsets in patients with pars planitis. CD4+CD57+ and CD8+CD57+ T cells were quantitated in peripheral blood from 15 patients with pars planitis and 15 healthy controls. To evaluate the phenotype and potential function of CD57+ T cell subsets CCR7, CD27, CD28, CD45RA, CD45RO, intracellular IFN-gamma, IL-4, perforin and granzyme-A expression were assessed by flow cytometry. CD57+ T cells subsets were increased in patients with pars planitis (p = 0.002). The majority of CD4+CD57+ T cells were CCR7-CD27-CD28-CD45RO+, while the most CD8+CD57+ T cells were CCR7-CD27-CD28-CD45RA+. The number of cells positive for intracellular IFN-gamma and IL-4 was higher in the CD57+ T cell populations. A greater number of CD8+CD57+ T cells than CD8+CD57- T cells were positive to perforin (p = 0.006) and granzyme-A (p = 0.01).
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CD57+ T cells had a phenotype associated with peripheral memory (CCR7-CD27-CD28-). Cytokine production by CD57+ T cells suggests that these cells may play a role in helper cell regulation. High expression of intracellular proteins involved in cytotoxicity suggests that CD8+CD57+ T cells may play an effector role. Taken together, this study proposes that CD57+ T cells function as memory-effector T cell subsets during pars planitis pathogenesis. Final Decision: yes