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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Colonic Neoplasms, Disease Progression, Down-Regulation, Female, Humans, Immunohistochemistry, Interferon Regulatory Factor-1, Male, Middle Aged, Protein Inhibitors of Activated STAT, Small Ubiquitin-Related Modifier Proteins, Tissue Array Analysis.
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Is substantially reduced expression of PIAS1 associated with colon cancer development? Context: Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expression in colon cancer. To determine whether PIAS1, one of the PIAS family members, or IFN-gamma signaling pathway components could be used to stratify colon tumors, we stained tissue microarrays for PIAS1, interferon regulatory factor-1 (IRF-1) and STAT1alpha. PIAS1 staining of the colon cancer tissue microarrays indicated a strong correlation of normal colon cells, and adenomas, with high expression of both PIAS1 and IRF-1.
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The PIAS1 results in particular may represent a basis for new approaches for efficiently distinguishing adenomas from colon cancer. Final Decision: yes