system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Apoptosis, Carcinoma, Renal Cell, Cell Line, Tumor, Cell Proliferation, Drug Resistance, Neoplasm, Female, Humans, Kidney Neoplasms, Mice, Mice, Nude, Nanoparticles, Plant Extracts, Quillaja, Quillaja Saponins, Transplantation, Heterologous.
user
Is the Nanoparticulate Quillaja Saponin BBE selectively active towards renal cell carcinoma? Context: To characterize the cytotoxic effect of BBE, the particulate of desacyl-saponin, in model systems of solid tumours. Cytotoxic activity of BBE was investigated in solid human tumour cell lines, in tumour cells from patients with renal cell carcinoma, in normal human renal cells and in peripheral blood mononuclear cells. The BBE mode of cell death was assessed in vitro. In vivo effect of BBE was evaluated in xenograft-bearing mice. BBE was selectively active against renal cell carcinoma, with no or little effect on normal cells. BBE induced caspase activity and apoptosis. An inhibitory activity of BBE on xenograft tumour growth, with no apparent signs of haematological toxicity was shown. In the non-proliferative model of patient tumour cells, BBE was active on only 1/5 patient samples, suggesting association of BBE effect with cell proliferation.
assistant
BBE has interesting activities against renal cell carcinoma and should be further explored as a drug against this resistant tumour type. Final Decision: yes