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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: MATERIAL AND METHODS, RESULTS. Meshes: Adolescent, Adult, Arthritis, Juvenile, Child, Chronic Disease, Cohort Studies, Female, Gene Frequency, HLA-C Antigens, HLA-DR Antigens, HLA-DRB1 Chains, HLA-DRB3 Chains, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Humans, Male, Middle Aged, Periodontal Attachment Loss, Periodontitis, Periodontium, Phenotype, Risk Factors, Smoking.
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Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis? Context: HLA-class I and II markers were determined using microlymphocytotoxicity test and polymerase chain reaction with sequence specific primers. Statistical analyses were carried out by chi(2)-test and Yates' correction. If n<5 Fisher's exact test was performed. In the arthritis group the influence of HLA on attachment loss was determined by using backwards logistic regression considering age, gender, smoking, plaque level, and the duration of the disease. In comparison with the controls HLA-DRB3(*) occurred more frequently in both females suffering from juvenile idiopathic arthritis (74.58%versus 54.54%, p=0.024) and females suffering from chronic periodontitis (73.02%versus 54.54%, p=0.035). Furthermore, among patients with juvenile idiopathic arthritis an increased odds ratio (OR) for attachment loss was found in subjects who expressed HLA-A(*)01 (OR=4.6, p=0.014) or HLA-A(*)01:DRB3(*) (OR=4.3, p=0.031).
assistant
HLA-DRB3(*) could be a common putative risk indicator for juvenile idiopathic arthritis and chronic periodontitis among females.