system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aging, Alkaloids, Animals, Cholinesterase Inhibitors, Male, Maze Learning, Memory, Memory Disorders, Rats, Rats, Sprague-Dawley, Scopolamine, Sesquiterpenes.
user
Does huperzine A ameliorate the impaired memory of aged rat in the Morris water maze performance? Context: To determine the memory-improving properties of huperzine A in aged rats with memory impairments naturally occurring or induced by scopolamine. Morris water maze was used to investigate the effects of huperzine A on the acquisition and memory impairments. During 7-day acquisition trials, aged rats took longer latency to find the platform. Huperzine A (0.1-0.2 mg/kg, s.c.) could significantly reduce the latency. In the probe trials on the eighth day, huperzine A (0.1, 0.2 and 0.4 mg/kg, s.c.) significantly increased the time in the quadrant where plateform had disappeared in aged rats. In the acute experiment, scopolamine (0.1 mg/kg, i.p.) significantly impaired spatial memory in the trained aged rats. Huperzine A (0.4 mg/kg, s.c.) significantly reversed the memory deficits induced by scopolamine.
assistant
Huperzine A ameliorates the impaired memory naturally occurring or induced by scopolamine in aged rats. Final Decision: yes