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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adalimumab, Antirheumatic Agents, Arthritis, Rheumatoid, Drug Hypersensitivity, Female, GPI-Linked Proteins, Genetic Predisposition to Disease, Humans, Injection Site Reaction, Japan, Male, Middle Aged, Polymorphism, Genetic, Receptors, IgG.
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Is fcγ receptor 3B polymorphism associated with hypersensitivity reactions to adalimumab in Japanese patients with rheumatoid arthritis? Context: To examine the association between Fcγ receptor (FcγR) polymorphisms and the development of hypersensitivity reactions to adalimumab in patients with rheumatoid arthritis. Sixty-five patients receiving adalimumab were enrolled in the study. Genetic polymorphisms for FcγR3B were genotyped in FCGR3B NA1/2 alleles by real allelic discrimination assay. Clinical information and the occurrence of a hypersensitivity reaction to adalimumab were collected from the patients' charts. A hypersensitivity reaction was observed in 12% of the patients. Clinical information obtained from patients with a reaction and those without were the same. The FCGR3B NA1/NA1, NA1/NA2, and NA2/NA2 alleles were found in 75%, 13%, and 13% of the patients with hypersensitivity reaction, respectively, and in 28%, 42%, and 30% of those without a hypersensitivity reaction, respectively (p = 0.04). Multivariate logistic regression analysis identified only the NA1/NA1 as an independent relevant factor for a hypersensitivity reaction to adalimumab (OR 7.7, p = 0.01).
assistant
The FCGR3B NA1/NA1 genotype is associated with hypersensitivity reactions to adalimumab. Final Decision: yes