system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Amyloid-rich stroma was seen on H&E stain of a thyroid nodule as shown below. What would be the diagnosis?
assistant
The correct answer is  Medullary Carcinoma of thyroid (MCT) Arise form para follicular 'C' Cells Derived from - Ultimobranchial bodies Secretes - calcitonin Level of calcitonin is raised Level of calcium is normal Clinical Features Midline swelling in anterior pa of neck Characteristic features Raised calcitonin History of diarrhea Presence of amyloid stroma Positive family history of Pheochromocytoma & Hyperparathyroidism (due to association with MEN 2A & MEN 2B)