system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Argentina, DNA, Mitochondrial, European Continental Ancestry Group, Female, Fetus, Genetic Predisposition to Disease, Genotype, Humans, Indians, South American, Infant, Newborn, Male, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Potassium Channels, Calcium-Activated, Premature Birth, Protein Isoforms, Receptors, Progesterone.
user
Are polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform associated with preterm birth in an Argentinian population? Context: To investigate genetic etiologies of preterm birth (PTB) in Argentina through evaluation of single-nucleotide polymorphisms (SNPs) in candidate genes and population genetic admixture. Genotyping was performed in 389 families. Maternal, paternal and fetal effects were studied separately. Mitochondrial DNA (mtDNA) was sequenced in 50 males and 50 females. Y-chromosome anthropological markers were evaluated in 50 males. Fetal association with PTB was found in the progesterone receptor (PGR, rs1942836; P=0.004). Maternal association with PTB was found in small conductance calcium activated potassium channel isoform 3 (KCNN3, rs883319; P=0.01). Gestational age associated with PTB in PGR rs1942836 at 32-36 weeks (P=0.0004). MtDNA sequencing determined 88 individuals had Amerindian consistent haplogroups. Two individuals had Amerindian Y-chromosome consistent haplotypes.
assistant
This study replicates single locus fetal associations with PTB in PGR, maternal association in KCNN3, and demonstrates possible effects for divergent racial admixture on PTB. Final Decision: yes