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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
"Orphan Annie eye nuclei" is characteristic histologic feature of which of the following thyroid malignancy ?
assistant
The correct answer is  Orphan Annie nuclei is a characteristic intranuclear inclusion seen mainly in papillary carcinoma of thyroid. Ultrastructurally they are seen as membrane bound spheroidal masses of cytoplasm intruding into the nuclei. Intranuclear inclusions are less commonly seen in hyalinizing trabecular adenomas, medullary carcinoma, huhle cell carcinoma as well as anaplastic carcinoma.