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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 35-year-old man presents with yellow discoloration of his eyes and skin for the past week. He also says he has pain in the right upper quadrant for the past few days. He is fatigued constantly and has recently developed acute onset itching all over his body. The patient denies any allergies. Past medical history is significant for ulcerative colitis diagnosed 2 years ago, managed medically. He is vaccinated against hepatitis A and B and denies any recent travel abroad. There is scleral icterus present, and mild hepatosplenomegaly is noted. The remainder of the physical examination is unremarkable. Laboratory findings are significant for:
Total bilirubin 3.4 mg/dL
Prothrombin time 12 s
Aspartate transaminase (AST) 158 IU/L
Alanine transaminase (ALT) 1161 IU/L
Alkaline phosphatase 502 IU/L
Serum albumin 3.1 g/dL
Perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) positive
Which of the following is the most likely diagnosis in this patient?
assistant
Primary sclerosing cholangitis