system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Most characteristic features of actual inflammation in-
assistant
The correct answer is  EFFECTS OF VARIOUS MEDIATORS
o Various effects of inflammatory mediators are
1. Increased vascular permeability Histamine, serotonin (5-hydroxytryptamine), anaphylatoxins (C3a, C4a, C5a), PAF, leukotrienes (LTC4, D4, E4), bradykinin.
□ PAF is the most potent one to increase permeability.
2. Chemoattractant C5a (most potent), IL-8, LTB4, PAF, bacterial products, Lymphokine, Kallikrein.
□ C5a is the most potent chemoattractant.
3. Vasodilatation Histamine, prostaglandins (PG D2, PGE2), prostacyclin (PGI2), serotonin. Nitric oxide, bradykinin.
4. Vasoconstriction Leukotrienes (LTC4, D4, E4), Thromboxane A2.
5. Bronchoconstriction Leukotrienes (LTC4, D4, E4), PFA, histamine, bradykinin.
□ Leukotrienes (LTC4, D4, E4) are the most potent bronchoconstrictors.
6. Pain Prostaglandins, bradykinin.
7. Fever (pyrogens) IL-1, TNF-αl IL-6, prostaglandins, interferon.