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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNLABELLED, OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Autoantibodies, Autonomic Nervous System Diseases, Brain, Chagas Disease, Chronic Disease, Female, Humans, Male, Middle Aged, Prospective Studies, Rabbits, Receptors, Adrenergic, beta, Receptors, Muscarinic, Trypanosoma cruzi.
user
Do the presence of antiautonomic membrane receptor antibodies correlate with brain lesions in Chagas ' disease? Context: We previously demonstrated correlation between parasympathetic dysfunction and brain white matter lesions in chronic chagasic patients. To correlate serum functional circulating antibodies with beta adrenergic (Ab-beta), muscarinic (Ab-M) or muscarinic and beta adrenergic (Ab-Mbeta) activity, the autonomic system function and brain lesions in chronic chagasic patients. In fifteen consecutive chagasic patients, the autonomic nervous system was evaluated and brain magnetic resonance imaging (MRI) was performed. The sera of all patients were tested to the presence of circulating functional antibodies. Sera from 11 of 15 chronic chagasic patients had some activity (Ab-beta: 7; Ab-M: 1; Ab-Mbeta: 3); however, there was no significant correlation between the presence of antibodies and the autonomic system function or the presence of hyperintensities in MRI.
assistant
The mechanism involved in the genesis of hyperintense lesions seen in brain MRI of chronic chagasic patients is still unresolved, although apparently related to parasympathetic dysfunction. Final Decision: no