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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adenocarcinoma, Cell Line, Tumor, Cell Proliferation, Epithelial-Mesenchymal Transition, Estradiol, Estrogens, Gene Expression, Humans, Matrix Metalloproteinase 9, Proto-Oncogene Proteins c-akt, Receptors, Estrogen, Salivary Gland Neoplasms.
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Does stimulation of the Estrogen Axis induce Epithelial-Mesenchymal Transition in Human Salivary Cancer cells? Context: Salivary gland cancer is a common type of head and neck cancer characterized by occasional deep invasion and lung metastasis. The precise role of sex steroid hormones in salivary gland cancer is unclear. To address this issue, we investigated whether the estrogen axis modulates salivary adenocarcinoma (SAC) and whether hormone therapy can be an effective treatment. The estrogen receptor (ER) was overexpressed in HSG human SAC cells that lack endogenous ER and the cells were treated with and without 17β-estradiol (E2). E2 enhanced malignant phenotypes. Moreover, E2 treatment reduced E-cadherin expression, while increasing that of N-cadherin, vimentin, and inhibitor of differentiation 1 proteins that are associated with the epithelial-mesenchymal transition. Cell invasion was enhanced through activation of matrix metalloproteinase-9.
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These results indicate that hormone therapy used in breast cancer may also be effective for ER-positive SAC. Final Decision: yes