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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Acoustic Stimulation, Adolescent, Adult, Auditory Perception, Brain Mapping, Cluster Analysis, Cortical Synchronization, Evoked Potentials, Evoked Potentials, Auditory, Female, Frontal Lobe, Humans, Male, Nerve Net, Reaction Time, Reference Values, Temporal Lobe, Young Adult.
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Does temporo-frontal phase synchronization support hierarchical network for mismatch negativity? Context: We performed an experiment designed to reveal the brain-regional network dynamics underlying both automatic and intentional auditory change detection as typically indexed by the mismatch negativity (MMN) event-related potential (ERP). High-density EEG was recorded while participants heard a stream of standard pure tones, into which occasional (14%) frequency deviants were inserted. In a first run they listened passively while watching a closed-captioned movie, whereas in a second run they pressed a button each time they detected a deviant while watching the movie with neither sound nor captioning. Independent component analysis revealed independent components that we localized to temporal and frontal regional brain sources relevant to the generation of the MMN. Relative power in various oscillatory frequency bands, computed from a wavelet analysis on the time series of these independent components, was modulated by task demands and stimulus type, as was dynamic phase-locking between pairs of the independent components in those same frequency bands.
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These results support a hierarchical model of MMN generation that emphasizes information processing and transfer between temporal and frontal brain regions. Final Decision: yes