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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Adult, Cytokines, Embryo Transfer, Female, Fertilization, Follicular Fluid, Gonadal Steroid Hormones, Humans, Immunoenzyme Techniques, Infertility, Male, Male, Middle Aged, Oocyte Retrieval, Ovarian Follicle, Ovulation Induction, Pregnancy, Prospective Studies, Sperm Injections, Intracytoplasmic, Treatment Outcome.
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Are the levels of steroid hormones and cytokines in individual follicles associated with the fertilization outcome after intracytoplasmic sperm injection? Context: To investigate the association between the levels of two steroid hormones and eight cytokines in fluids from individual follicles and the fertilization outcome of the oocytes derived from the same follicles. Prospective study. University hospital. Forty-three women participating in intracytoplasmic sperm injection (ICSI)/ET cycles. The ovarian stimulation followed the multidose GnRH antagonist protocol. ICSI was performed in mature oocytes. The concentrations of estradiol, progesterone, tumor necrosis factor-alpha, interleukin (IL) -1beta, IL-6, vascular endothelial growth factor, leptin, basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I were measured by immunoassay methods in the follicles from which the mature oocytes were derived. The concentrations of the above hormones and cytokines in individual follicles and the fertilization outcome of the oocytes derived from the same follicles. The intrafollicular concentrations of the above factors were not significantly associated with the fertilization outcome. These factors were not correlated with embryo quality, with the exception of leptin, which was weakly associated with embryo score (R = 0.276).
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The intrafollicular concentrations of the above factors cannot predict the fertilization outcome after ICSI. Final Decision: no