system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Analysis of Variance, Connective Tissue Growth Factor, Double-Blind Method, Female, Humans, Knee Joint, Male, Middle Aged, Osteoarthritis, Knee, Radiography, Severity of Illness Index, Statistics, Nonparametric, Synovial Fluid.
user
Are plasma and synovial fluid connective tissue growth factor levels correlated with disease severity in patients with knee osteoarthritis? Context: Connective tissue growth factor (CTGF) has been implicated in development of osteoarthritis (OA). To determine the correlation between plasma and synovial fluid CTGF levels and the severity in knee osteoarthritis patients. A total of 100 subjects were recruited into this study (75 OA patients and 25 controls). CTGF concentrations in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay. Plasma and synovial fluid CTGF concentrations were correlated with radiographic severity. There was a positive correlation between plasma and synovial fluid CTGF levels.
assistant
CTGF could be useful for monitoring the severity and progression of OA. Final Decision: yes