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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Burns, Female, Humans, Intercellular Adhesion Molecule-1, Keratinocytes, Male, Skin, Wound Healing.
user
Do [ The expression of ICAM-1 on the keratinocytes in second degree human burn skin ]? Context: To investigate the significance of changes in intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes(KCs) during wound healing of second degree burn. With immunohistochemistry technique, the ICAM-1 expression in second degree burn wounds in patients were investigated at four different postburn periods. The normal skins from 6 burn patients (BNG), the normal skins from 8 healthy volunteers (HVG) and the scar tissues (SG) from 8 patients served as controls. There was poor expression of ICAM-1 on basal cells in normal skins of healthy volunteers, while the expression of ICAM-1 enhanced in normal skins of burn patients. On basal cells in second degree burn wounds, the expression of ICAM-1 slightly increased in the first week postburn, obviously enhanced in the second week, and in the third or fourth week, the expression continued to keep strong. In addition, the ICAM-1 in KCs showed polar distribution, and the expression of ICAM-1 markedly enhanced on the multilayer KCs in neogenetic epithelium and the positive cells arranged columnarly.
assistant
The enhanced expression of ICAM-1 on KCs in second degree burn wounds might be related to invasion of inflammatory cells beneath wound. It might play a role in inducing proliferation and migration of KCs and accelerating epithelization. Final Decision: yes