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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adrenocorticotropic Hormone, Age Factors, Animals, Biomarkers, Blood Glucose, Corticosterone, Diet, High-Fat, Disease Susceptibility, Ethanol, Female, Fetal Alcohol Spectrum Disorders, Hypothalamo-Hypophyseal System, Insulin, Lipids, Liver, Male, Maternal Exposure, Metabolic Syndrome, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Rats, Wistar, Risk Factors, Weight Gain.
user
Does prenatal ethanol exposure enhance the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming? Context: The present study was designed to demonstrate that prenatal ethanol exposure (PEE) could enhance the susceptibility of high-fat diet-induced metabolic syndrome (MS) in adult male offspring via a hypothalamic-pituitary-adrenal (HPA) axis-associated neuroendocrine metabolic programmed mechanism. Pregnant Wistar rats were intragastricly administrated ethanol 4 g/kg·d from gestational day 11 until term delivery. All male offspring were fed with high-fat diet after weaning, exposed to an unpredictable chronic stress at postnatal week (PW) 17 and sacrificed at PW20. In PEE group, body weight presented a "catch-up growth" pattern, and the HPA axis exhibited a lower basal activity but an enhanced sensitivity to chronic stress, leading to increased levels of serum glucose, insulin, insulin resistant index, total cholesterol and low-density lipoprotein-cholesterol, and decreased levels of high-density lipoprotein-cholesterol. Furthermore, many lipid droplets and vacuolar degeneration were observed in the hypothalamus, pituitary gland and liver.
assistant
PEE induces enhanced susceptibility to MS in adult offspring fed with high-fat diet, and the underlying mechanism involves a HPA axis-associated neuroendocrine metabolic programming alteration. Final Decision: yes