system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
All of the following factors tend to increase the volume of distribution of a drug except
assistant
The correct answer is  Ref - katzung10/e p34,35 If a drug is highly bound to plazma proteins it is more likely to statin blood. Thus its Vd will be less. Low ionizition ours the distribution of drug because unionized molecules can cross the membrane of blood vessel and tissue.