system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Cells, Cultured, Cilia, Ciliary Motility Disorders, Epithelial Cells, Female, Humans, Male, Middle Aged, Nasal Mucosa, Povidone-Iodine, Respiratory Mucosa.
user
Does betadine have a ciliotoxic effect on ciliated human respiratory cells? Context: This study investigated the effect of Betadine on ciliated human respiratory epithelial cells. Epithelial cells from human sinonasal mucosa were cultured at the air-liquid interface. The cultures were tested with Hanks' balanced salt solution containing 10 mM HEPES (control), 100 µM ATP (positive control), 5 per cent Betadine or 10 per cent Betadine (clinical dose). Ciliary beat frequency was analysed using a high-speed camera on a computer imaging system. Undiluted 10 per cent Betadine (n = 6) decreased the proportion of actively beating cilia over 1 minute (p < 0.01). Ciliary beat frequency decreased from 11.15 ± 4.64 Hz to no detectable activity. The result was similar with 5 per cent Betadine (n = 7), with no significant difference compared with the 10 per cent solution findings.
assistant
Betadine, at either 5 and 10 per cent, was ciliotoxic. Caution should be applied to the use of topical Betadine solution on the respiratory mucosal surface. Final Decision: yes