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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Apoptosis Regulatory Proteins, China, Cyclophosphamide, Disease Progression, Disease-Free Survival, Doxorubicin, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotyping Techniques, Humans, Interleukin-10, Kaplan-Meier Estimate, Leptin, Lymphoma, Non-Hodgkin, Lymphotoxin-alpha, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Polymorphism, Single Nucleotide, Prednisone, Prognosis, Receptors, Leptin, Risk Factors, Treatment Outcome, Tumor Necrosis Factor-alpha, Vincristine, Young Adult.
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Is lymphotoxin alpha ( LTA ) polymorphism associated with prognosis of non-Hodgkin 's lymphoma in a Chinese population? Context: Non-Hodgkin's lymphoma (NHL) has been widely reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the survival and prognosis of NHL patients. To evaluate the role of such genetic variations in prognosis of NHL, we conducted this study in a Chinese population. We used the TaqMan assay to genotype six single nucleotide polymorphisms (SNPs) (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T) for 215 NHL cases. Kaplan-Meier analysis was performed to compare progression free survival among two common genotypes. Cox proportional hazard models were used to identify independent risk factors. We observed that LTA rs1800683G>A was significantly associated with risk of progression or relapse in NHL patients (HR = 1.63, 95%CI = 1.06-2.51; P = 0.028), particularly in Diffuse large B cell lymphoma (DLBCL) cases (HR = 1.50, 95%CI = 1.10-2.04, P = 0.01). Both univariate and multivariate Cox regression analysis showed that in DLBCL patients, Ann Arbor stage III/IV, elevated LDH level before treatment and LTA rs1800683 AA genotype carrier were independent risk factors for progression or relapse. While in NK/T cell lymphoma, Ann Arbor stage III/IV and elevated β2-MG level before treatment indicated poorer prognosis.
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The polymorphism of LTA rs1800683G>A contributes to NHL prognosis in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results. Final Decision: yes