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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Anaphylaxis, Animals, Female, Histamine, Hypersensitivity, Kinetics, Lung, Mast Cells, Mice, Mice, Inbred BALB C, Nebulizers and Vaporizers, Serotonin, Toxocara canis, Toxocariasis, Ultrasonics, Water.
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Does ultrasonically nebulized distilled water prevent exogenous histamine hyperreactivity in Toxocara canis-infected mice? Context: This study examines the effect of ultrasonically nebulized distilled water inhalation on the systemic histamine hyperreactivity of Toxocara canis-infected mice. Uninfected and T. canis-infected mice received an intravenous sublethal dose of histamine and lethality rates were documented. At 24 days post infection, infected mice received ultrasonically nebulized distilled water inhalation for 1 h. Twenty-four hours later histamine levels were determined in bronchoalveolar lavage fluid as well as histamine lethality and toluidine blue-stained mast cell number in the lung. T. canis-infected mice showed increased lethality after exposure to histamine in comparison to uninfected mice. Ultrasonically nebulized distilled water inhalation prevented histamine-induced lethality and reduced toluidine blue-stained mast cell numbers in the lung.
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The correlation between decreases in stained mast cells in the lung after ultrasonically nebulized distilled water inhalation and inhibition of histamine-induced lethality in these animals suggests participation of mast cells in the phenomenon and could be helpful in understanding the mechanisms of hyperreactivity during helminth parasite infections. Final Decision: yes