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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Aspirin in low doses produces long lasting inhibition of platelet cyclooxygenase because:
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The correct answer is  Aspirin in low doses irreversibly inhibits COX enzyme in platelets and the endothelium. Platelets lack nucleus and thus cannot regenerate COX whereas endothelium can synthesize fresh enzyme. Net effect of this process is the inhibition of platelet cox and thus, TXA2 synthesis. Low TXA2 level results in the anti-aggregation of platelets.