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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
True regarding ondansetron are all of the following except: March 2010
assistant
The correct answer is  Ans. C: Significant Drug Interactions Ondansetron is the prototype of new class of antiemetic drugs developed to control chemotherapy/radiotherapy induced vomiting, and later found to be highly effective in postoperative nausea and vomiting as well. It blocks the action of 5-HT through 5-HT3 receptors on vagal afferents in the GIT as well as in NTS and CTZ. A minor 5-HT4 antagonistic action has also been shown. It is hydroxylated by CYP 1A2, 2D6 and 3A, but no clinically significant drug interactions have been noted.