system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 16-year-old boy presents with a long-standing history of anemia. Past medical history is significant for prolonged neonatal jaundice and multiple episodes of jaundice without fever. On physical examination, the patient shows generalized pallor, scleral icterus, and splenomegaly. His hemoglobin is 10 g/dL, and examination of a peripheral blood smear shows red cell basophilic stippling. Which of the following is the most likely diagnosis in this patient?
assistant
Pyrimidine 5’-nucleotidase deficiency