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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Cerebrovascular Circulation, Delusions, Female, Humans, Ischemia, Male, Regression Analysis, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon.
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Does insular hypoperfusion correlate with the severity of delusions in individuals with Alzheimer 's disease? Context: The aim of this study was to identify the brain regions associated with the severity of delusions in individuals with Alzheimer's disease (AD) using single-photon emission computed tomography. Thirty-five AD patients participated in this study. Multiple regression analysis was performed to identify a linear correlation between the delusion subscale score of the Neuropsychiatric Inventory (NPI) and regional cerebral blood flow (rCBF) in AD patients with delusions (n = 14). In addition, rCBF in patients with (n = 14) and without delusions (n = 21) was compared using a 2-sample t test. The delusion subscale score of the NPI was negatively correlated with rCBF in the right anterior insula (uncorrected p < 0.01 at the voxel level and corrected p < 0.05 at the cluster level). Compared to patients without delusions, however, rCBF in the right anterior insula was not significantly decreased in patients with delusions.
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We suggest that right anterior insular dysfunction may exacerbate delusions, although it is not responsible for the onset of delusions. Final Decision: yes