system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 5-day-old term male neonate presents with delayed passage of meconium, abdominal distension and bilious vomiting. Barium enema and intestinal biopsy findings are shown below: What is the diagnosis?
assistant
The correct answer is  1st picture shows narrow distal segment with dilated proximal segment of intestine in Ba enema. 2nd picture shows hyperophied nerve bundles between muscular layer & submucosa and enteric nerve plexuses lacking ganglion cells in H&E stain. Both the above findings are suggestive of Hirschsprung disease (Congenital aganglionic megacolon)