system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Middle Aged, Nerve Degeneration, Nerve Growth Factors, Personality Inventory, Reference Values, S100 Calcium Binding Protein beta Subunit, S100 Proteins.
user
Is s-100B increased in melancholic but not in non-melancholic major depression? Context: Recent evidence suggests that neurodegeneration may be involved in the pathophysiology of major depression. The astroglial peptide S-100B was shown to be increased in many diseases causing neuronal cell damage or degeneration. S-100B plasma levels were determined in 28 patients with major depression and 28 matched healthy controls using an immunofluorometric sandwich assay. Patients suffering from melancholic depression showed significantly increased S-100B levels compared to healthy controls while non-melancholic patients demonstrated normal levels.
assistant
Medication of patients varied. The differentiation between melancholic and non-melancholic patients was performed clinically without using a standardized instrument. Final Decision: yes