system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Ammonia is toxic to the brain because it leads to depletion of which substrate?
assistant
The correct answer is  Ans. B. Alpha ketoglutarateAmmonia reacts with Glutamate to form Glutamine. The Glutamate is formed from alpha keto glutarate an intermediate of TCA Cycle. So alpha ketoglutarate is depleted.