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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Biomarkers, C-Reactive Protein, Firefighters, Fires, Forced Expiratory Volume, Humans, Inflammation, Lung, Male, Middle Aged, Occupational Exposure, Physical Fitness, Spirometry, Surveys and Questionnaires, Vital Capacity.
user
Is high hsCRP associated with reduced lung function in structural firefighters? Context: To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters. We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1 s (FEV1 %-predicted) and forced vital capacity (FVC%-predicted). Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1 %-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).
assistant
hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters. Final Decision: yes