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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adenocarcinoma, Mucinous, Aged, Aged, 80 and over, Aspergillus oryzae, Carcinoma, Pancreatic Ductal, Carcinoma, Papillary, Cell Transformation, Neoplastic, Female, Fucose, Fucosyltransferases, Gene Expression, Humans, Lectins, Male, Microarray Analysis, Middle Aged, Pancreatic Neoplasms, Polysaccharides, Protein Binding.
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Is fucosylation associated with the malignant transformation of intraductal papillary mucinous neoplasms : a lectin microarray-based study? Context: Intraductal papillary mucinous neoplasm (IPMN) is an intraductal mucin-producing pancreatic neoplasm with the potential for malignant transformation. Changes in glycans expressed on the cell surface and glycotransferases play important roles in malignant transformation. We conducted this study to analyze glycan alterations in IPMNs by using a lectin microarray and to identify the factors associated with altered glycans and their relationships with malignant transformation. Using a lectin microarray, we evaluated glycan expression in 22 samples of IPMN with carcinoma, obtained from curative resections performed in our department. We also used immunohistochemistry to investigate fucosyltransferase 8 (Fut 8) protein expression, which is associated with glycan alterations in IPMNs. The lectin microarray demonstrated that only two lectins, Aleuria aurantia lectin (AAL) and Aspergillus oryzae L-fucose-specific lectin (AOL), which bind to fucose, exhibited significant sequential increases from normal pancreatic duct to adenoma and carcinoma. Similarly, Fut 8 protein expression, which is associated with AAL and AOL, sequentially and significantly increased from the normal pancreatic duct to adenoma and carcinoma.
assistant
Lectin microarray analysis suggested that fucosylation is associated with the malignant transformation of IPMNs. Final Decision: yes