system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 40 years old female presented to OPD with this lesion in the breast. What is the most probable diagnosis?
assistant
The correct answer is  PAGET'S DISEASE is a superficial manifestation of an underlying breast carcinoma (95%) it presents as an eczema like condition of nipple and areola that persists despite treatment. Microscopically, Paget's disease is characterized by the presence of large, ovoid cells with abundant clear, pale staining cytoplasm in the Malpighian layer of epidermis. Treatment: mastectomy + axillary staging or wide local excision of nipple and areola to achieve clear margins, axillary sampling and radiation therapy. PEAU-D-ORANGE