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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
What is the basis of this statement - 'FATS BURN IN THE FLAME OF CARBOHYDRATES ':
assistant
The correct answer is  "Fats burn in the flame of carbohydrates" means fats can only be oxidized in the presence of carbohydrates. Acetyl CoA is a fat derivative, which can be oxidized TCA cycle. As Oxaloacetate is the carrier of TCA cycle So, TCA cycle can operate only if oxaloacetate is available in sufficient amounts. Now oxaloacetate is mainly produced from pyruvate by pyruvate carboxylase. Pyruvate is mainly produced from glycolysis of carbohydrates. So we can say that main source of oxaloacetate is carbohydrates. As carbohydrates are the main source of oxaloacetate which is required for oxidation of acetyl-CoA (produced from fats) through TCA. Hence this statement "Fats burn in the flame of carbohydrates".