system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 40-year-old woman in her 18th week of pregnancy based on the last menstrual period (LMP) presents to her obstetrician for an antenatal check-up.
The antenatal testing is normal, except the quadruple screen results which are given below:
Maternal serum alpha-fetoprotein (MS-AFP) low
Unconjugated estriol low
Human chorionic gonadotropin (hCG) high
Inhibin-A high
Which of the following conditions is the most likely the cause of the abnormal quadruple screen?
assistant
Trisomy 21