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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Alkaloids, Animals, Antioxidants, Apoptosis, Blotting, Western, Disease Models, Animal, Heme Oxygenase-1, Immunohistochemistry, In Situ Nick-End Labeling, Kidney, Male, NF-E2-Related Factor 2, Oxidative Stress, Quinolizines, Random Allocation, Rats, Sprague-Dawley, Reperfusion Injury, Reproducibility of Results, Time Factors, Treatment Outcome.
user
Does oxymatrine ameliorate renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway? Context: To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats and explore the possible role of oxymatrine in Nrf2/HO-1 pathway. Unilaterally nephrectomized rats were insulted by I/R in their left kidney. Twenty four rats were randomly divided into three groups: sham group, I/R + saline-treated group, I/R + OMT-treated group. Oxymatrine or vehicle solution was administered intraperitoneally injected 60 min before renal ischemia, respectively. Renal function, histology, makers of oxidative stress, cell apoptosis and Nrf2/HO-1 expressions were assessed. Oxymatrine pretreatment exhibited an improved renal functional recovery, alleviated histological injury and oxidative stress, inhibiting tubular apoptosis, and accompanied by upregulated the expression of Nrf2/HO-1 proteins.
assistant
Oxymatrine may attenuate renal ischemia/reperfusion injury, and this renoprotective effect may be through activating the Nrf2/HO-1 pathway. Final Decision: yes