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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Animals, Culicidae, DNA, Complementary, Liver, Malaria, Male, Mice, Mice, Knockout, Plasmodium berghei, RNA, Protozoan, RNA, Ribosomal, 18S, Reverse Transcriptase Polymerase Chain Reaction, Scavenger Receptors, Class A, Sporozoites, Vaccination.
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Are infection by and protective immune responses against Plasmodium berghei ANKA affected in macrophage scavenger receptors A deficient mice? Context: Scavenger receptors (SRs) recognize endogenous molecules modified by pathological processes as well as components of diverse microorganisms. Mice deficient for both SR-AI and II are more susceptible to infections by a variety of bacterial and viral pathogens. Here we show that SR-A deficient mice and wild type mice are equally susceptible to malaria infection both during liver and blood stages. Moreover, like wild type mice, SR-A deficient mice are able to mount a protective immune response against radiation attenuated sporozoites.
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Our results do not reveal a function of SR-A I and II receptors in the Plasmodium berghei ANKA infection, both in the development of CM and parasitemia control. Moreover, these receptors appear not to be required for the establishment of a protective immune response against the malaria liver stages. Final Decision: no