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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Albuminuria, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Glomerular Filtration Rate, Glycated Hemoglobin A, Humans, Hyperlipidemias, Hypertension, Hypoglycemic Agents, Hypolipidemic Agents, Kidney, Longitudinal Studies, Male, Middle Aged, Retrospective Studies.
user
Are aggressive antihypertensive treatment and serum lipid lowering therapy necessary to prevent deterioration of the renal function even in elderly type 2 diabetic patients with persistent albuminuria? Context: In elderly patients with diabetic nephropathy, clinical information aiming at preventing a decline of the renal function is limited. To clarify factors that could be related to changes in renal function in elderly diabetic patients with persistent albuminuria. We studied the relationships between the declining rate of creatinine clearance (Ccr) and other clinical features - glycemic control, blood pressure (BP), the degree of albuminuria, and other confounding factors - retrospectively in elderly diabetic patients with persistent albuminuria. We analyzed 17 elderly diabetic patients with persistent albuminuria (4 men and 13 women, mean age 68.0 +/- 5.7 years at the beginning of the observation period) for 3.7 +/- 1.5 (SD) years. We found that the last value of the urinary albumin excretion (UAE) of the observation period and the individual mean values of systolic BP, mean BP, and serum cholesterol closely correlated with the rate of decline in Ccr estimated by Cockcroft's formula. The last UAE closely correlated with the individual mean values of systolic BP and mean BP. For patients such as the present subjects, adequate retardation of decline in renal function requires that the estimated goal of antihypertensive treatment should be a BP below 130/70 mm Hg. The level of glycemic control and the use of angiotensin-converting enzyme inhibitors did not correlate with the rate of decline in Ccr.
assistant
Aggressive antihypertensive treatment and serum lipid lowering therapy may be necessary to prevent deterioration of the renal function in elderly type 2 diabetic patients with persistent albuminuria. Final Decision: yes