system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
As compared to unfractionated heparin, low molecular weight heparin -
assistant
The correct answer is  Ans. is 'a' i.e., Are absorbed more uniformly when given subcutaneously o Unfractionated heparin binds to several plasma proteins, therefore it has less predictable dose-response profile when administered sc or iv. o On the other hand, LMW heparins are less protein bound and have a predictable dose response profile when administered sc or iv. About other options o Since aPTT/clotting time are not prolonged (much) with LMW heparins, laboratory monitoring is not needed. o LMW heparins are unsuitable for HIT as antibody may be cross-reactive. Agent of choice in HIT are direct thrombin inhibitors like hirudin, lepirudin, bivalirudin. o Osteoporosis (osteopenia) occurs as a dose related side effect of unfractionated heparin. The relative risk with LMW heparin is not yet estabilished.