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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Biomarkers, Chronic Disease, Disease Resistance, Female, Gene Expression Regulation, Humans, Intercellular Adhesion Molecule-1, Lung Diseases, Obstructive, Male, Middle Aged, Smoking, Solubility.
user
Are increased levels of soluble ICAM-1 in chronic obstructive pulmonary disease and resistant smokers related to active smoking? Context: Serum ICAM-1 (sICAM-1) is known to be a smoking-associated inflammatory marker, but data in chronic obstructive pulmonary disease (COPD) are lacking. A total of 142 COPD cases (48 active smokers) and 55 controls (41 active smokers) were consecutively enrolled in this cross-sectional study. The peripheral blood concentrations of sICAM-1, IL-8 (CXCL8), CRP and serum amyloid A (SAA) were determined by ELISA. CRP and SAA (log-scale) were elevated in the patients with COPD compared with the control subjects (p = 0.005 for CRP and p = 0.024 for SAA). sICAM-1 was associated with active smoking when corrected for age, gender, the presence of COPD, inhaled corticosteroid use, BMI and forced expiratory volume in 1 s as covariates.
assistant
The present study confirms an association between sICAM-1 levels and active smoking in a group of COPD and non-COPD active smokers. Final Decision: yes