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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Cisplatin, Disease-Free Survival, Female, Humans, Lung Neoplasms, Male, Middle Aged, Neoadjuvant Therapy, Neutropenia, Perioperative Care, Retrospective Studies, Treatment Outcome.
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Is early-onset neutropenia during perioperative chemotherapy predictive of increased survival in patients with completely resected non-small cell lung cancer : a retrospective analysis? Context: Chemotherapy-induced neutropenia (CIN) has been found to be predictive of better therapeutic outcomes in studies of patients with various tumors. This study investigated whether CIN occurring during perioperative chemotherapy cycles 1 or 2 is a prognostic indicator in patients with completely resected non-small cell lung cancer (NSCLC). The records of patients with completely resected NSCLC receiving at least two cycles of perioperative platinum-based doublet chemotherapy were reviewed retrospectively. Early-onset CIN was defined as a neutrophil count <2.0 × 10(9)/l during chemotherapy cycles 1 or 2. Subjects were stratified into two groups: presence or absence of early-onset CIN. A total of 93 patients were included in this analysis. Early-onset CIN developed in 54.8% (51/93) cases. The median overall survival (OS) of patients developing early-onset CIN was significantly longer than the survival of patients without early-onset CIN (92.4 vs. 35.8 months, p=0.022), and the median disease-free survival (DFS) of patients with early-onset CIN was also longer, although the difference was not significant (48.3 vs. 18.6 months, p=0.138). Multivariate analysis demonstrated that early-onset CIN was an independent prognostic indicator for OS [hazard ratio (HR) for death=0.422, 95% confidence interval (CI)=0.201-0.884; p=0.022] and DFS (HR for recurrence=0.482, 95% CI=0.247-0.943; p=0.033).
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Early-onset CIN during perioperative chemotherapy is predictive of better OS and DFS in patients with completely resected NSCLC. Final Decision: yes