system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND. Meshes: Adult, Aryl Hydrocarbon Hydroxylases, Citalopram, Cross-Over Studies, Cytochrome P-450 CYP2C19, Drug Interactions, Female, Humans, Male, Omeprazole, Serotonin Uptake Inhibitors, Young Adult.
user
Does omeprazole preferentially inhibit the metabolism of ( + ) - ( S ) -citalopram in healthy volunteers? Context: Citalopram (CITA) pharmacokinetics are enantioselective in healthy volunteers and the metabolism of (+)-(S)-CITA to (+)-(S)-DCITA is dependent on CYP2C19. Omeprazole is a potent CYP2C19 inhibitor.
assistant
This study indicates that omeprazole induces a loss of enantioselectivity in the CITA pharmacokinetics because of the selective inhibition of (+)-(S)-CITA metabolism. Final Decision: yes