system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: ATP Binding Cassette Transporter, Subfamily B, Member 11, ATP-Binding Cassette Transporters, Amino Acid Motifs, Amino Acid Substitution, Animals, Cholestasis, Chromatin, Consensus Sequence, Gene Expression Regulation, Gene Knockdown Techniques, Hep G2 Cells, Humans, Liver, Mice, Mice, Inbred C57BL, Mutagenesis, Site-Directed, Promoter Regions, Genetic, Protein Binding, Protein Processing, Post-Translational, Protein Transport, RNA, Small Interfering, Receptors, Cytoplasmic and Nuclear, SUMO-1 Protein, Small Ubiquitin-Related Modifier Proteins, Sumoylation, Transcription, Genetic.
user
Does sUMOylation of the farnesoid X receptor ( FXR ) regulate the expression of FXR target genes? Context: Small ubiquitin-like modifiers (SUMO) are covalently conjugated to other proteins including nuclear receptors leading to modification of various cellular processes. Ligand-dependent SUMOylation of farnesoid X receptor (FXR) negatively regulates the expression of its target genes.
assistant
SUMO modification attenuates the capacity of FXR to function as a transcriptional activator. Final Decision: yes