system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Splenomegaly may be a feature of: March 2013
assistant
The correct answer is  Ans. B i.e. Sickle cell anemia Splenomegaly Splenomegaly refers strictly to spleen enlargement, and is distinct from hyperspineism , which connotes overactive function by a spleen of any size. Splenomegaly and hypersplenism should not be confused. Each may be found separately, or they may coexist. Clinically if a spleen is palpable, it means it is enlarged as it has to undergo enlargement by at least two folds to become palpable. However, the tip of the spleen may be palpable in a newborn baby up to 3 months of age Early sickle cell anemia may present with splenomegaly