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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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A drug administered through which of the following routes undergo high first pass metabolism?
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The correct answer is  First pass metabolism refers to metabolism of a drug during its passage from the site of absorption into the systemic circulation. Drugs administered through the oral route undergo high first pass metabolism since it is exposed to drug metabolizing enzymes in the intestinal wall and liver. Reference: Essentials of Medical Pharmacology by K D Tripathi 5th edition page 25.