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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Albuminuria, Biomarkers, Blood Pressure, Cholesterol, HDL, Cholesterol, LDL, Cohort Studies, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Disease Progression, Female, Glycated Hemoglobin A, Humans, Lipids, Lipoprotein(a), Male, Middle Aged, Predictive Value of Tests, Risk Factors, Triglycerides.
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Are serum triglycerides a predictive factor for the development and the progression of renal and retinal complications in patients with type 1 diabetes? Context: It is controversial that serum lipIds affect the development and progression of microvascular complications in patients with type 1 diabetes. We prospectively followed 297 patients with type 1 diabetes without end-stage renal disease for 7 Years (range: 2-10). Serum lipIds were measured at baseline (total and HDL-cholesterol, triglycerIdes and calculated LDL-cholesterol, Lipoprotein (a)). The primary end-point was the occurrence of a renal event and the secondary end-point was the occurrence of a retinal event, defined as the progression to a higher stage of diabetic nephropathy or retinopathy, respectively. Serum triglycerIde (TG) levels were higher in patients who progressed in nephropathy than in those who dId not [median 1.21 (range 0.41-2.96) vs 0.91 (0.31-11.07) mmol/l; p=0.0037] and in those who developed retinal events than in those who dId not [1.05 (0.46-8.27) vs 0.87 mmol/l (0.31-11.07); p=0.0302], both in the whole cohort and in patients with normoalbuminuria at baseline. After adjustment for systolic blood pressure (SBP), diabetes duration, gender, stage of complications at baseline and glycohemoglobin (HbA1c), the relative risk for progression was 2.01 (95% CI: 1.07-3.77) for nephropathy and 2.30 (95% CI: 1.03-5.12) for retinopathy for patients having serum TG in the highest tertile, compared to the others. This result persisted when only patients with normoalbuminuria were consIdered.
assistant
High triglycerIde levels are an independent predictive factor of both renal and retinal complications in patients with type 1 diabetes. Final Decision: yes