system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Fibrin is degraded by ?
assistant
The correct answer is  Coagulation must be balanced with fibrinolysis to limit the hemostatic plug to the site of injury. Injured vascular endothelium secret plasminogen activator that conves inactive plasminogen to active plasmin. Plasmin breaks down fibrin resulting in production of fibrin degradation products. Fibrinolytic system is regulated by plasminogen activator inhibitors (PAIs) that are secreted by endothelium.