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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Alkaline Phosphatase, Alveolar Process, Animals, Bone Density, Dental Cementum, Disease Models, Animal, Genetic Therapy, Hypophosphatemia, Mice, Mice, Knockout, Tooth Exfoliation, Treatment Outcome.
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Does gene therapy improve dental manifestations in hypophosphatasia model mice? Context: Hypophosphatasia is a rare inherited skeletal disorder characterized by defective bone mineralization and deficiency of tissue non-specific alkaline phosphatase (TNSALP) activity. The disease is caused by mutations in the liver/bone/kidney alkaline phosphatase gene (ALPL) encoding TNSALP. Early exfoliation of primary teeth owing to disturbed cementum formation, periodontal ligament weakness and alveolar bone resorption are major complications encountered in oral findings, and discovery of early loss of primary teeth in a dental examination often leads to early diagnosis of hypophosphatasia. Although there are no known fundamental treatments or effective dental approaches to prevent early exfoliation of primary teeth in affected patients, several possible treatments have recently been described, including gene therapy. Gene therapy has also been applied to TNSALP knockout mice (Alpl Following sublethal irradiation (4 Gy) at the age of 2 d, Alpl Immunohistochemical analysis of osteopontin, a marker of acellular cementum, revealed that Alpl
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Our results suggest that gene therapy can improve the general condition of Alpl Final Decision: yes