system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Atorvastatin, Centchroman, Chromatography, High Pressure Liquid, Contraceptives, Oral, Contraceptives, Postcoital, Synthetic, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Rats, Rats, Sprague-Dawley, Rosuvastatin Calcium.
user
Does coadministration of HMG-CoA reductase inhibitors , atorvastatin and rosuvastatin , affect contraceptive efficacy of centchroman? Context: The study aimed to investigate the effect of concomitant use of atorvastatin or rosuvastatin on the pharmacokinetic and pharmacodynamic profile of centchroman, a non-steroidal female oral contraceptive. A rat model was used to predict pharmacokinetic drug-drug interactions between centchroman and atorvastatin or rosuvastatin. A dried blood spot sampling technique followed by liquid chromatography-tandem mass spectrometry detection was employed for analysis of the pharmacokinetic interaction study samples. Sperm-positive female rats were investigated for postcoital contraceptive activity of centchroman with or without coadministration of atorvastatin or rosuvastatin. Coadministration of atorvastatin or rosuvastatin may increase the systemic availability of centchroman in blood, but it does not affect the pharmacodynamic profile of centchroman.
assistant
Atorvastatin or rosuvastatin may be prescribed with centchroman without compromising the contraceptive efficacy of centchroman. Final Decision: no