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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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In which of the following disorders is administration of barbiturates contraindicated in
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The correct answer is  Contraindications of barbiturates: Acute intermittent porphyria- Barbiturates exacerbate it by inducing microsomal enzymes (d aminolevulinic acid synthetase) and increasing porphyrin synthesis. Liver and kidney disease Severe pulmonary insufficiency e.g. emphysema Obstructive sleep apnoea Uses of barbiturates: Anxiety disorders Epilepsy Kernicterus / Congenital nonhemolytic jaundice : Phenobarbitone induces conjugation of bilirubin and hastens clearance of jaundice.