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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Carcinoma, Mucoepidermoid, Cause of Death, Disease-Free Survival, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Male, Middle Aged, Mucin-1, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Staging, Parotid Neoplasms, Prognosis, Radiotherapy, Adjuvant, Salivary Gland Neoplasms, Submandibular Gland Neoplasms, Survival Rate, Treatment Outcome, Young Adult.
user
Does increased expression of MUC-1 have close relation with patient survivor in high-grade salivary gland mucoepidermoid carcinoma? Context: High-grade mucoepidermoid carcinoma (MEC) is an infrequent malignant neoplasm originates most commonly in the salivary glands with poor prognosis. Thus far, there is little knowledge on MUC-1 expression in high-grade MEC or how it may relate to patient survival. The aim of this study was to determine the extent of MUC-1 expression in high-grade MEC and correlate expression with clinic outcome. Surgical specimens from 62 cases of primary high-grade MEC and 10 cases of normal salivary gland tissue were examined by immunohistochemistry. The relationship between MUC-1 expression and the clinicopathological data and patient survival was analyzed. The disease-free survival rates were 54.6% (3 years) and 37.7% (5 years) for high-grade MEC patients. Patient who with primary location at submandibular gland have the worst prognosis (P = 0.042) in comparing with other sites. High expression of MUC-1 in high-grade MEC was significantly correlated with lymphatic/regional metastasis (P = 0.003) and clinic stage (P = 0.02), and high expression of MUC-1 (>75%) was confirmed to be significant independent prognostic factors in high-grade MEC patients [HR 2.929 (95% CI 1.246-6.881); P < 0.0137].
assistant
The findings suggest that high levels of MUC-1 expression may be a potential marker for worse outcome in high-grade MEC and could be used as a new molecule target to improve outcomes for these patients in the future. Final Decision: yes