system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNLABELLED, RESULTS. Meshes: Anemia, Neonatal, Enzyme-Linked Immunosorbent Assay, Erythropoiesis, Erythropoietin, Hematocrit, Humans, Infant, Newborn, Infant, Premature, Diseases, Infusions, Intravenous, Phlebotomy, Recombinant Proteins, Respiration, Artificial, Treatment Outcome.
user
Do serum erythropoietin concentrations fail to increase after significant phlebotomy losses in ill preterm infants? Context: OBJECTIVE/STUDY DESIGN: After blood loss, production of erythropoietin in adults increases, which accelerates erythropoiesis and restores the erythroid mass. It is unclear whether preterm infants with large phlebotomy losses have a similar response. We therefore measured serum erythropoietin concentrations in 11 ill preterm infants (1057 +/- 167 gm) as their phlebotomy losses accumulated. Before the first transfusion, erythropoietin concentrations were 68.9 +/- 36.2 mU/ml (range 0 to 205 mU/ml) at 5 ml/kg blood out, 17.4 +/- 8.9 mU/ml at 10 ml/kg, and 4.8 +/- 2.6 mU/ml at 15 ml/kg. Erythropoietin concentrations did not increase in any patients despite increasing phlebotomy losses.
assistant
Serum erythropoietin concentrations in ill preterm infants do not increase in the face of significant blood loss. Although the mechanistic explanation for this failure is unclear, it likely contributes to the transfusion requirements of this population. Final Decision: yes