system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 10-year-old boy is brought to the emergency department by his mother due to frequent vomiting, abdominal pain, and weakness. Over the last 5 days, has been noted to have polydipsia and polyuria. Family history is irrelevant. His temperature is 37.1°C (98.7°F), blood pressure is 100/70 mm Hg, and pulse is 110/min. Physical examination reveals no response to verbal commands, sunken eyes, poor skin turgor, and rapid deep respirations. Laboratory results are shown:
Random plasma glucose 420 mg/dL
Serum beta-hydroxybutyrate elevated
Fasting C-peptide undetectable
Antiglutamic acid decarboxylase (GAD) antibodies positive
This patient's condition occurs as a result of which of the following?
assistant
Immune-mediated destruction of pancreatic beta cells