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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Alanine Transaminase, Antiviral Agents, Biomarkers, Drug Therapy, Combination, Female, Hepatitis C, Chronic, Humans, Interferon-alpha, Male, MicroRNAs, Middle Aged, Polyethylene Glycols, Real-Time Polymerase Chain Reaction, Recombinant Proteins, Reverse Transcriptase Polymerase Chain Reaction, Ribavirin.
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Is pretreatment serum microRNA-122 predictive for treatment response in chronic hepatitis C virus infection? Context: MicroRNA-122 is a liver specific microRNA and is elevated in the sera of patients with chronic hepatitis C virus infection. Hepatic microRNA-122 levels have been described to be reduced in patients with non-response to antiviral treatment with pegylated interferon-α and ribavirin. Assessment of differences in serum microRNA-122 levels in patients with sustained virological response and non-response. RNA was extracted from pretreatment serum samples and microRNA-122 and microRNA-16 levels were measured by quantitative PCR and compared in patients with sustained virological response and non-response. The levels of microRNA-122 and microRNA-16 in the sera did not differ between patients with sustained virological response and non-response.
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Serum microRNA-122 is not a suitable marker for treatment response prediction to combination therapy with pegylated interferon-α and ribavirin in patients with chronic hepatitis C virus infection. Final Decision: no