system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 38-year-old woman presents with generalized weakness and dizziness for the past 3 weeks. Past medical history is significant for systemic lupus erythematosus diagnosed 15 years ago, for which she takes hydroxychloroquine and methotrexate. No significant family history. Her vital signs include: temperature 37.1°C (98.7°F), blood pressure 122/65 mm Hg, pulse 100/min. Physical examination reveals generalized pallor; sclera are icteric. Her laboratory results are significant for the following:
Hemoglobin 7.3 g/dL
Mean corpuscular hemoglobin (MCH) 45 pg/cell
Reticulocyte count 6%
Direct antiglobulin test Positive
Peripheral blood smear 7 spherocytes
Which of the following best represents the most likely cause of this patient's condition?
assistant
IgG-mediated hemolysis