system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Biomarkers, Brain, Female, Heart Function Tests, Humans, Infant, Newborn, Infant, Premature, Male, Natriuretic Peptide, Brain, Oxygen, Peptide Fragments, Prospective Studies.
user
Is cerebral tissue oxygen saturation associated with N-terminal probrain natriuretic peptide in preterm infants on their first day of life? Context: This prospective observational study investigated if N-terminal probrain natriuretic peptide (NT-proBNP), a cardiac biomarker, correlated with cerebral tissue oxygen saturation (crSO2) in preterm infants on their first day of life. Using near infrared spectroscopy (NIRS), crSO2 was measured on the right forehead of preterm infants for 24 h. We also recorded arterial oxygen saturation (SpO2 ) and calculated fractional tissue oxygen extraction (cFTOE) values. At the end of the NIRS measurement, blood was taken to analyse NT-proBNP. Mean values for the 24-h period were calculated for crSO2 , cFTOE, SpO2 and these values were correlated to NT-proBNP. An echocardiography was performed in all infants during the measurement period. We analysed 35 preterm neonates (33 ± 2 weeks, 1965 ± 523 g). NIRS measurements started at 3 ± 1 h and blood samples were taken at 24 ± 5 h postnatal. Echocardiography showed an open ductus arteriosus in all infants. Mean NT-proBNP was 4978 ± 3566 pg/mL, crSO2 was 76 ± 8%, and cFTOE was 0.20 ± 0.08. NT-proBNP correlated negatively with crSO2 (r = -0.75; p ≤ 0.001) and positively with cFTOE (r = 0.731; p ≤ 0.001).
assistant
These results emphasise that crSO2 is influenced by cardiac function, in addition to oxygen consumption, arterial oxygen saturation and vascular resistance, and this can be measured by NT-proBNP. Final Decision: yes