system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Antibodies, Viral, Antibody Affinity, Biomarkers, Capsid Proteins, Chemokine CXCL10, Child, Child, Preschool, DNA, Viral, Epitopes, Female, Humans, Immunoglobulin G, Immunoglobulin M, Male, Middle Aged, Parvoviridae Infections, Parvovirus B19, Human, Pregnancy, Retrospective Studies, Viral Load, Young Adult.
user
Is the chemokine CXCL-10 a marker for the infection stage in individuals with Parvovirus B19 DNAemia? Context:  Accurate diagnosis of Parvovirus B19 (B19V) infection requires the differentiation between acute and past infection, which is especially important when B19V DNAemia is detected in pregnancy. Here, we explored the ability of the chemokine CXCL-10 in combination with molecular and serological assays to discriminate between acute and past B19V infection.  B19V DNA positive serum samples from 222 immunocompetent individuals were analyzed for (a) viral DNA loads, (b) anti-B19V IgM and IgG, (c) anti-VP1 IgG avidity, (d) anti-VP-2 epitope type specificity (ETS) as well as for (e) CXCL-10 serum levels.  Using anti-B19V IgM and IgG, avidity and ETS assays, individuals with B19V DNAemia were staged for acute or past infection. Acute B19V infection caused a significant increase of the CXCL-10 serum concentration from uninfected baseline. Higher CXCL-10 serum levels were furthermore detected in acute B19V infection as compared to past infection. As a marker, CXCL-10 could discriminate between acute and past B19V infection, with an excellent discriminatory capacity when CXCL-10 and B19V DNA levels were used as combined parameters.
assistant
 Acute B19V infection is associated with increased CXCL-10 production and measurement of CXCL-10 serum levels thus allows for the staging of B19V infection in individuals with B19V DNAemia. Final Decision: yes