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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 53-year-old woman presents to the physician with palpitations and increasing swelling of the legs over the past 3 months. During this time, she has also had generalized pruritus. She has dyspnea on exertion. She has no history of asthma. She occasionally takes ibuprofen for chronic headaches she has had for several years. She does not smoke or drink alcohol. The pulse is 92/min and irregular, blood pressure is 115/65 mm Hg, temperature is 36.7°C (98.1°F), and respiratory rate are 16/min. On physical examination, the skin shows papules and linear scratch marks on the limbs and trunk. She has 2+ pitting edema. Auscultation of the heart shows irregular heartbeats. Examination of the lungs shows no abnormalities. The spleen is palpated 5 cm (1.9 in) below the costal margin. No lymphadenopathy is palpated. The results of the laboratory studies show:
Hemoglobin 14 g/dL
Leukocyte count 17,500/mm3
Percent segmented neutrophils 25.5%
Lymphocytes 16.5%
Eosinophils 52%
Basophils 2%
Platelet count 285,000/mm3
Echocardiography is consistent with restrictive-pattern cardiomyopathy and shows thickening of the mitral valve and a thrombus in the left ventricular apex. Abdominal ultrasound confirms splenomegaly and shows ascites. Which of the following best explains these findings?
assistant
Hypereosinophilic syndrome