system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Down regulation of hormone means ?
assistant
The correct answer is  Ans. is 'b' i.e., Decreased affinity to receptors Down regulation is a mechanism in which a hormone decrease the number or affinity of its receptors in target tissues. Down-regulation may occur by decreasing the synthesis of new receptors, by increasing the degradation of existing receptors or by inactivating receptors. The purpose of down-regulation is to reduce the sensitivity of the target tissue when hormone levels are high for an extended period of time.