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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Antimetabolites, Antineoplastic, Chemotherapy, Adjuvant, Colorectal Neoplasms, DNA, Neoplasm, Female, Fluorouracil, Follow-Up Studies, Humans, Integrin alpha2, Integrin beta3, Male, Middle Aged, Neoplasm Recurrence, Local, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Prognosis, Retrospective Studies, Survival Rate.
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Are single nucleotide polymorphisms of integrin alpha-2 and beta-3 genes associated with relapse-free and overall survival in colorectal cancer patients? Context: Integrins influence tumourigenesis, tumor progression and development of metastases. The impact of polymorphisms in integrin genes on relapse-free survival (RFS) and overall survival (OS) for 433 Caucasian patients with colorectal cancer was analysed in this retrospective study. A Cox regression model including integrin genotype, age, grading, tumour size, number of lymph nodes examined, number of metastatic lymph nodes, stage and application of fluorouracil-based adjuvant chemotherapy was used to estimate their effect. After a median follow-up of 41 months for RFS and 55 months for OS, no significant correlation between the ITGA2 1648A allele (RFS p=0.618, OS p=0.604), the ITGA2 807T allele (RFS p=0.603, OS p=0.807) and the ITGB3 176C allele (RFS p=0.719, OS p=0.261) and survival was detectable.
assistant
The investigated integrin polymorphisms are not associated with RFS or OS in colorectal cancer patients. Final Decision: no