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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Case-Control Studies, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-1alpha, Interleukin-1beta, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Promoter Regions, Genetic, Spain.
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Is cytokine IL-1 beta but not IL-1 alpha promoter polymorphism associated with Alzheimer disease in a population from the Canary Islands , Spain? Context: Previous studies have reported the presence of low-grade inflammation in Alzheimer disease (AD). Based on these data, our work attempts to investigate the effects of some promoter polymorphisms of pro-inflammatory cytokines [interleukin (IL)-1 alpha and IL-1 beta] on AD. A PCR-RFLP technique was used to analyze the promoter polymorphisms of both IL-1 alpha (-889 C/T) and IL-1 beta (-511 C/T) and the APOE genotype from the DNA samples of 282 patients (according to NINCDS-ADRDA criteria) and 312 control subjects. (i) The risk of developing AD in our population was associated with the IL-1 beta (-511 C/T) promoter polymorphism; (ii) such risk was independent of the risk factor allele in the APOE gene (APOE4); and (iii) the IL-1 alpha promoter polymorphism (-889 C/T) was not associated with the disease.
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In our population, IL-1 beta promoter polymorphism (-511 C/T) is an independent risk factor for AD. Final Decision: yes