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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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E cadherin gene deficiency is seen in-
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The correct answer is  Harshmohan textbook of pathology 7th edition. Familial gastric cancer is strongly associated with germline loss of function mutation in the tumor suppressor gene CDH1, which encoded the cell adhesion protein E- catherin. Loss of function mutation in CDH1 are also present in about 50% of sporadic diffuse gastric tumor, while E- Catherin expression is drastically decreased in the rest. often by hyper methylation and silencing of the CDH1 promoter. This the loss of E Catherin is the key step in the development of diffuse gastric cancer..