system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Blood Pressure, Cardiopulmonary Bypass, Cerebrovascular Disorders, Female, Humans, Hypothermia, Induced, Longitudinal Studies, Male, Memory Disorders, Middle Aged, Perfusion, Treatment Outcome.
user
Is lower perfusion pressure during hypothermic cardiopulmonary bypass associated with decreased cerebral blood flow and impaired memory performance 6 months postoperatively? Context: We undertook to determine the influence of perfusion pressure during hypothermic cardiopulmonary bypass (CPB) on cerebral blood flow (CBF) and cognitive memory outcome at 6 months postoperatively. Nineteen patients who underwent hypothermic nonpulsatile CPB for elective coronary artery bypass (CAB) surgery were evaluated by (133)Xe measurement of the CBF and by the Incidental Memory Assessment for evaluating cognitive memory (IMTscore), both at baseline before the operation (T(1)) and again at 5 to 6 months postoperatively (T(2)). Overall, the mean CBF fell significantly from 39 +/- 5 mL.(100 g)(-1).min(-1) at T(1) to 33 +/- 3 mL.(100 g)(-1).min(-1) at T(2) (P < .001). The decrease in CBF from T(1) to T(2) (DeltaCBF(2-1)) correlated with a significant reduction in the IMTscore from T1 to T2 (DeltaIMTscore(2-1)) (P < .001) and with a mean arterial pressure during CPB (MAPCPB) of <60 mm Hg (P = .05). Cluster analysis of DeltaCBF(2-1) and DeltaIMTscore(2-1) demonstrated that the patients with the greatest decrease in CBF showed the greatest decrease in IMTscore, whereas cluster analysis of DeltaCBF(2-1) and MAPCPB indicated that patients with a perfusion pressure maintained at a mean of <60 mm Hg during CPB were prone to a greater decrease in later postoperative CBF.
assistant
This study demonstrated that a MAPCPB of <60 mm Hg during CPB was associated with a significant decrease in CBF 6 months after CAB surgery and with an associated decrease in memory performance. Final Decision: yes