system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Animals, Biopsy, Endocardium, Female, Graft Rejection, Heart Transplantation, Humans, Male, Middle Aged, Myocardium, Predictive Value of Tests, Rats, Signal Processing, Computer-Assisted, Spectrometry, Fluorescence.
user
Fluorescence spectroscopy of endomyocardial tissue post-human heart transplantation: does it correlate with histopathology? Context: A significant correlation between autofluorescence spectroscopy and heart allograft rejection has been described in the rat heterotropic allograft model. However, the use of this technique in human heart transplants has not been validate. We obtained fluorescence and reflectance spectra on 37 human endomyocardial biopsy specimens and correlated the spectra with International Society Heart and Lung Transplantation grade for histologic rejection. Using different excitation wavelengths (ultraviolet, lambda = 337 nm; blue, lambda = 440 nm, and green, lambda = 486 nm), we found no significant difference in the fluorescence spectra among the different grades of rejection.
assistant
Fluorescence spectroscopy is not a sensitive method for detecting rejection in human heart transplant recipients.