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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, B7-H1 Antigen, Biomarkers, Tumor, Carcinoma, Cyclin-Dependent Kinase Inhibitor p16, Female, Gastrectomy, Herpesvirus 4, Human, Humans, Lymphatic Metastasis, Male, Middle Aged, MutL Protein Homolog 1, MutS Homolog 2 Protein, Neoplasm Invasiveness, Nuclear Proteins, PTEN Phosphohydrolase, Prognosis, Retrospective Studies, Risk Factors, Stomach Neoplasms, Survival Rate, Tissue Array Analysis, Transcription Factors, Tumor Burden, Tumor Suppressor Protein p53.
user
Is biomarkers of EBV-positive Gastric Cancers : Loss of PTEN Expression Associated with Poor Prognosis and Nodal Metastasis? Context: Epstein-Barr virus-positive gastric carcinoma (EBVGC) constitutes approximately 10 % of all gastric carcinoma cases. While distinct molecular features have been characterized previously, there have not been studies identifying their clinical utility. The purpose of this study was to investigate the immunohistochemistry (IHC) profile of EBVGC and to evaluate the potential clinicopathologic and prognostic significance of each marker. Clinicopathologic characteristics of 234 patients (203 males and 31 females) who underwent curative gastrectomy for EBVGCs from 1998 to 2013 at Asan Medical Center, were reviewed, and IHC for ARID1A, PTEN, PD-L1, p53, p16(INK4a), MLH1, and MSH2 were performed on tissue microarrays. These markers along with several tumor characteristics, e.g., lymphovascular invasion and the extent of differentiation, were analyzed for significant associations as well as any prognostic significance by multivariate analysis. In multivariate analysis, PTEN loss was as an independent factor associated with poor prognosis (p = 0.011). Furthermore, PTEN loss was an independent risk factor for nodal metastasis (p = 0.038). No other biomarkers, ARID1A, PD-L1, p53, p16(INK4a), MLH1, or MSH2, demonstrated significant prognostic value.
assistant
PTEN loss in EBVGC is a poor prognostic factor associated with mortality and nodal metastasis in EBVGCs. Evaluation of PTEN expression may be helpful to determine the most appropriate treatment strategy, especially for endoscopically resected EBVGCs. Final Decision: yes