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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Cryopreservation, Embryo Transfer, Female, Humans, Pregnancy, Pregnancy Outcome, Retrospective Studies, Sperm Injections, Intracytoplasmic.
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Does fertilization by intracytoplasmic sperm injection ( ICSI ) impair subsequent pregnancy outcome following frozen embryo transfer ( ET ) as determined by a large retrospective analysis? Context: To determine if fertilization by intracytoplasmic sperm injection (ICSI) adversely affects pregnancy outcome following frozen embryo transfer (ET). Retrospective analysis of frozen ETs where the oocytes were fertilized by conventional insemination vs ICSI was carried out. No difference in pregnancy outcome was found in women up to age 42. There was a non-significant trend for lower pregnancy rates in women age 43 and older.
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In the largest series to date by far these data convincingly show that fertilization by ICSI does not impair outcome following frozen ET. Final Decision: no