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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Abortion, Spontaneous, Adult, Chorionic Gonadotropin, Female, Fertilization in Vitro, Humans, Maternal Age, Ovary, Pregnancy, Retrospective Studies.
user
Is poor response after hormonal stimulation for in vitro fertilization related to ovarian aging? Context: To investigate whether the diminished efficacy of ART in young poor responders compared to young normal responders is due to a quantitative or a qualitative oocyte factor. Retrospective comparative analysis. University-based infertility center. Nine thousand six hundred forty-four patients who underwent ART procedures at our hospital from 1993 until 2001. Controlled ovarian hyperstimulation, ultrasonographic monitoring of the ovarian response, oocyte retrieval, ART procedure, embryo transfer, and follow-up of pregnant patients until 12 weeks of amenorrhea. Clinical rates of pregnancy and miscarriage. Nine thousand six hundred forty-four ART cycles were analyzed. The pregnancy rate for poor responders was significantly lower than for normal responders (17% vs. 35%). In cycles in which two good-quality embryos were transferred, the pregnancy rate was similar in poor responders and normal responders (33% vs. 42%). The rate of miscarriage was no higher in poor responders than normal responders.
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Young poor responders have a lower pregnancy rate than young normal responders because they have fewer oocytes, which leads to fewer good-quality embryos to choose from for transfer. The quality of their oocytes and embryos is not inferior to that of normal responders. Final Decision: no