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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Wof agent is used to prevent hemorrhagic cystitis caused by cyclophosphamide and ifosfamide
assistant
The correct answer is  To prevent hemorrhagic cystitis mesna is routinely given with the drugs. Mesna is a -SH compound that is excreted in urine--binds and inactivates the vasicotoxic metabolites(Acrolein) of ifosfamide and cyclophosphamide. Ref:- kd tripathi; pg num:-860