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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Acid Phosphatase, Administration, Oral, Alveolar Bone Loss, Alveolar Process, Animals, Anti-Infective Agents, Bone Remodeling, Cattle, Cell Count, Epithelial Attachment, Escherichia coli, Isoenzymes, Lactoferrin, Lipopolysaccharides, Liposomes, Male, Osteoclasts, Periodontitis, Pilot Projects, RANK Ligand, Random Allocation, Rats, Rats, Wistar, Stress, Mechanical, Tartrate-Resistant Acid Phosphatase, Tooth Cervix, Tooth Movement Techniques, Tumor Necrosis Factor-alpha.
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Does orally administered liposomal lactoferrin inhibit inflammation-related bone breakdown without interrupting orthodontic tooth movement? Context: Bovine lactoferrin (bLF) modulates the production of tumor necrosis factor-alpha (TNF-α) and inhibits alveolar bone breakdown associated with periodontitis. This study is designed to examine the effects of orally administered liposomal bLF (LbLF) on orthodontic force (OF)-induced alveolar bone remodeling during experimental tooth movement. Two groups of male Wistar rats were treated with either LbLF or control solution in drinking water 7 days before OF application. Lipopolysaccharide (LPS) was injected into the gingival sulcus in half the rats in each group. Thus, four groups: OF, OF+LbLF, OF+LPS, and OF+LPS+LbLF were established. Orally administered LbLF significantly reduced apical migration of junctional epithelium in the OF and OF+LPS groups. In OF+LPS, osteoclast number in the alveolar crestal area was increased by LPS treatment, whereas osteoclast number was significantly reduced in OF+LPS+LbLF through suppression of TNF-α production. Osteoclastic induction in the middle part, mainly from OF application, was not affected by LbLF administration. Inhibition of tooth movement was not induced by LbLF.
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Orally administered LbLF significantly inhibits LPS-induced alveolar bone resorption but not OF-induced bone remodeling. LbLF could be a potent therapeutic and preventive agent to control periodontal inflammation in patients undergoing orthodontic treatment. Final Decision: yes