system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: METHODS, RESULTS. Meshes: Adolescent, Antibodies, Antineutrophil Cytoplasmic, Biliary Tract Diseases, Child, Child, Preschool, Colitis, Diagnosis, Differential, Female, Gastrointestinal Hemorrhage, Humans, Inflammatory Bowel Diseases, Male, Myeloblastin, Vasculitis, Central Nervous System.
user
C-ANCA/proteinase 3-positive colitis in children: a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation? Context: Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype. The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P<0.05). None had vasculitis features at diagnosis nor during follow-up.
assistant
This pilot study demonstrates significant clinical differences between the PR3-ANCA-positive and -negative IBD subset.