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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: METHODS, RESULTS. Meshes: Animals, Body Weight, Diabetes Mellitus, Experimental, Dietary Supplements, Fatty Acids, Female, Heart, Linoleoyl-CoA Desaturase, Lipid Metabolism, Lipid Peroxidation, Male, Myocardium, Nitric Oxide, Olive Oil, PPAR alpha, Pregnancy, Pregnancy in Diabetics, Rats, Wistar.
user
Is intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats prevented by maternal diets enriched in olive oil? Context: Maternal diabetes can program metabolic and cardiovascular diseases in the offspring. The aim of this work was to address whether an olive oil supplemented diet during pregnancy can prevent lipid metabolic alterations in the heart of the offspring of mild diabetic rats. Control and diabetic Wistar rats were fed during pregnancy with either a standard diet or a 6% olive oil supplemented diet. The heart of adult offspring from diabetic rats showed increases in lipid concentrations (triglycerides in males and phospholipids, cholesterol, and free fatty acids in females), which were prevented with the maternal diets enriched in olive oil. Maternal olive oil supplementation increased the content of unsaturated fatty acids in the hearts of both female and male offspring from diabetic rats (possibly due to a reduction in lipoperoxidation), increased the expression of Δ6 desaturase in the heart of male offspring from diabetic rats, and increased the expression of peroxisome proliferator activated receptor α in the hearts of both female and male offspring from diabetic rats.
assistant
Relevant alterations in cardiac lipid metabolism were evident in the adult offspring of a mild diabetic rat model, and regulated by maternal diets enriched in olive oil. Final Decision: yes