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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Blood Glucose, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Electromyography, Female, Humans, Male, Middle Aged, Motor Neurons, Muscle Contraction, Muscle Weakness, Nerve Degeneration, Sensory Receptor Cells.
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Does motor nerve decline underlie muscle weakness in type 2 diabetic neuropathy? Context: Type 2 diabetes mellitus (DM2) patients may have decreased muscle strength. This decline can have multiple causes, among them diabetic polyneuropathy (DPN). We sought to determine the effect of nerve deterioration on muscle strength in DM2 patients with and without DPN. Nineteen DM2 patients with DPN (DPN group), 15 DM2 patients without DPN (DC group), and 18 healthy subjects (HC group) were recruited. We determined motor and sensory nerve function of the lower extremity. Isometric dynamometry was performed to determine maximum torque of the ankle joint. The DPN group had significantly diminished nerve function and muscle strength (P < 0.05) compared with both other groups. Only muscle strength was lower in DC subjects compared with HCs. No significant correlations were found between nerve function and muscle strength.
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These results indicate that reduced ankle joint torque in DM2 patients with and without DPN is independent of the presence of disturbed nerve function. Final Decision: no