system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Animals, Apolipoproteins E, Carotid Artery Injuries, Carotid Artery, Common, Dietary Fats, Disease Models, Animal, Enzyme Activation, Female, Inflammation, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases, Mice, Mice, Knockout, Molecular Imaging, Protease Inhibitors, Time Factors, Tomography, Emission-Computed, Single-Photon, X-Ray Microtomography.
user
Does matrix metalloproteinase activation predict amelioration of remodeling after dietary modification in injured arteries? Context: To establish and validate early noninvasive imaging of matrix metalloproteinase (MMP) activation for monitoring the progression of vascular remodeling and response to dietary modification. Apolipoprotein E(-/-) mice that were fed a high-fat diet underwent left common carotid artery wire injury. One week after surgery, a group of animals were withdrawn from the high-fat diet. The other group of animals continued that diet throughout the study. Micro single-photon emission computed tomographic (microSPECT)/CT imaging with RP805 (a (99m)Tc-labeled tracer targeting activated MMPs) was repeatedly performed at 2 and 4 weeks after surgery. Histological analysis at 4 weeks showed significant left carotid neointima formation, monocyte/macrophage infiltration, and upregulation of several MMPs, which were ameliorated by withdrawal from the high-fat diet. In vivo microSPECT/CT images visualized significant RP805 uptake, reflecting MMP activation, in the injured carotid arteries. MMP activation was reduced as early as 1 week after withdrawal from the high-fat diet and significantly correlated with neointimal area at 4 weeks after surgery.
assistant
MMP activation predicts the progression of vascular remodeling and can track the effect of dietary modification after vascular injury. Final Decision: yes