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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Carcinoma, Renal Cell, DNA, Neoplasm, Disease Progression, Female, Humans, Kidney Neoplasms, Male, Middle Aged, Ploidies, Prognosis, Proto-Oncogene Proteins c-bcl-2, S Phase, Survival Analysis.
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Bcl-2 protein and DNA ploidy in renal cell carcinoma: do they affect patient prognosis? Context: Both parameters were prospectively measured in 50 consecutive radical nephrectomy specimens using flow cytometry. They were correlated with the tumor grade, stage and histological type. Kaplan-Meier survival analysis for all parameters was performed. Bcl-2 protein expression was higher in RCC compared to normal renal tissue (P<0.0001). Aneuploid tumors had higher bcl-2 expression compared to diploid tumors (P = 0.015). Bcl-2 expression and DNA content were not correlated with tumor histological types (P = 0.277/P = 0.419), grades (P = 0.690/P = 0.449), T categories (P = 0.637/P = 0.585) or stages (P = 0.726/P = 0.800). Median follow-up time was 46 months (range, 5-84) with a mean overall survival of 61.8 months (95% confidence interval, 53.7-69.9). Tumor stage was the only statistically important prognostic factor (P = 0.0045).
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Although Bcl-2 expression was correlated with tumor DNA content, the prognostic value of these two parameters following radical nephrectomy was not established.