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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Acetylcholine, Animals, Cardiopulmonary Bypass, Creatine Kinase, Disease Models, Animal, Dogs, Endothelium, Vascular, Enzyme Inhibitors, Lactic Acid, Mesenteric Artery, Superior, Mesenteric Veins, Nitroprusside, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, Regional Blood Flow, Time Factors, Vascular Resistance, Vasodilation, Vasodilator Agents.
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Does poly-ADP-ribose polymerase inhibition reduce mesenteric injury after cardiopulmonary bypass? Context: We investigated the effects of PARS inhibition on intestinal injury in a canine model of cardiopulmonary bypass (CPB). Twelve dogs underwent 90 minutes of hypothermic CPB. 6 dogs received 5 mg/kg PJ34, a selective PARP inhibitor during CPB, 6 vehicle-treated animals served as controls. Mesenteric blood flow (MBF) and mesenteric vascular resistance (MVR) were measured before and 60 minutes after weaning from CPB. Endothelium-dependent vasorelaxation to acetylcholine (ACH) and endothelium-independent vasorelaxation to sodium-nitroprusside (SNP) were expressed as percent change of MVR. In addition, mesenteric creatine kinase (CK) and lactate release were determined. Baseline hemodynamics, MBF, response to ACH (- 41 +/- 3 vs. - 55 +/- 6 %) and SNP (- 60 +/- 2 vs. - 56 +/- 4 %) did not differ significantly between the groups. The response to ACH decreased significantly in the control group while it remained unchanged in the PJ34 group (- 29 +/- 5 vs. - 46 +/- 9 %, p < 0.05). The response to SNP did not change. Mesenteric CK release (325 +/- 99 vs. 16 +/- 10 U/l, p < 0.05) and lactate production (0.96 +/- 0.17 vs. 0.4 +/- 0.2 mmol/l, p < 0.05) were significantly lower in the PJ34 group.
assistant
PARP inhibition prevents CPB-induced mesenteric endothelial dysfunction and tissue damage. Final Decision: yes