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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Adolescent, Adult, Asian Continental Ancestry Group, Child, Child, Preschool, Cholestenone 5 alpha-Reductase, Cryptorchidism, Humans, Infant, Japan, Male, Mutation, Oligospermia, Oxidoreductases, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Testis.
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Do 5Alpha-reductase type 2 genes in Japanese males appear to be associated with cryptorchidism? Context: To evaluate the occurrence of mutations of 5alpha-reductase type 2 gene in patients with cryptorchidism or idiopathic azoospermia. Controlled clinical study. Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan. Patients with isolated cryptorchidism (n = 48) or idiopathic azoospermia (n = 33) and a control group of males with proven fertility (n = 51). Collection and analysis of blood, leukocytic DNA, semen, and testicular biopsy. Semen analysis, screening of the 5alpha-reductase type 2 gene within exon 1 using direct sequencing and exons 2-5 using single strand conformational polymorphism analysis. No mutations were detected in isolated cryptorchid men, idiopathic azoospermic men, or controls within the 5 exons of the 5alpha-reductase type 2 gene.
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5Alpha-reductase type 2 gene abnormalities do not constitute a major factor in the development of cryptorchidism or idiopathic azoospermia. Final Decision: no