system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: 2-Pyridinylmethylsulfinylbenzimidazoles, Amoxicillin, Animals, Anti-Bacterial Agents, Anti-Ulcer Agents, Clarithromycin, Drug Therapy, Combination, Gastric Mucosa, Gastritis, Gerbillinae, Helicobacter Infections, Helicobacter pylori, Lansoprazole, Male, Omeprazole, Specific Pathogen-Free Organisms.
user
Does anti-Helicobacter pylori therapy significantly reduce Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils? Context: To investigate the effectiveness of 4 d' anti-Helicobacter pylori therapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes. We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2X10(8) CFU/mL). Seven weeks after H pylori inoculation, the animals of study group received 4 d' anti-H pylori triple therapy (H pylori-eradicated group). Seven days later, all animals of the H pylori-eradicated and control groups (H pylori-infected and H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E(2) level. The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected group. Stomach weight ratio, MPO activity and PGE(2) levels were significantly higher in H pylori-infected group than those in the other two groups.
assistant
Four days' anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils. Final Decision: yes