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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Asthma, Child, Preschool, Cohort Studies, Dermatitis, Atopic, Dietary Supplements, Female, Finland, Follow-Up Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Kaplan-Meier Estimate, Male, Pregnancy, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal, Surveys and Questionnaires, Vitamin D.
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Is maternal vitamin D intake during pregnancy inversely associated with asthma and allergic rhinitis in 5-year-old children? Context: Vitamin D is known to have a number of immunological effects and it may play a role in preventing allergic diseases. Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes. Children (1669) participating in the population-based birth cohort study were followed for asthma, AR, and atopic eczema assessed by validated questionnaire at 5 years. Maternal diet was assessed by a food-frequency questionnaire. The mean maternal intake of vitamin D was 5.1 (SD 2.6) microg from food and 1.4 (2.6) microg from supplements. Only 32% of the women were taking vitamin D supplements. When adjusted for potential confounders, maternal intake of vitamin D from food was negatively related to risk of asthma [hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.64-0.99] and AR [HR 0.85; 95% CI 0.75-0.97]. Vitamin D supplements alone were not associated with any outcome. Adjustment for maternal intake of other dietary factors did not change the results.
assistant
Maternal vitamin D intake from foods during pregnancy may be negatively associated with risk of asthma and AR in childhood. Final Decision: yes