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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Cartilage, Collagenases, Female, Interleukin-1, Interleukin-1alpha, Interleukin-1beta, Mice, Mice, Inbred C57BL, Mice, Knockout, Osteoarthritis, Real-Time Polymerase Chain Reaction, Synovial Membrane, Synovitis, Transcriptome.
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Is interleukin-1 involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis? Context: Interleukin-1 (IL-1) is an alleged important cytokine in osteoarthritis (OA), although the exact contribution of IL-1 to joint destruction remains unclear. Here we investigated the involvement of IL-1α and IL-1β in joint pathology during collagenase-induced OA (CiOA). CiOA was induced in wild type (WT) and IL-1αβ Synovial IL-1β expression was strongly elevated 7 days after induction of CiOA in WT mice but decreased afterwards, whereas S100A8/A9, previously described to aggravate OA, remained elevated for 21 days. Remarkably, synovial inflammation was comparable between WT and IL-1αβ
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IL-1α and IL-1β are not involved in synovial inflammation and cartilage destruction during CiOA, implicating that other mediators are responsible for the joint damage. Final Decision: no