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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Base Sequence, DNA, Exons, Female, Greece, Humans, Mutation, Nucleic Acid Denaturation, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Primary Ovarian Insufficiency, Receptors, FSH.
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Are follicle-stimulating hormone receptor gene mutations evident in Greek women with premature ovarian failure and poor responders? Context: This clinical and molecular study aimed to investigate the presence of follicle-stimulating hormone (FSH) receptor gene mutations in women with premature ovarian failure (POF) and poor responders to in vitro fertilization treatment. DNA was extracted from blood samples for subsequent polymerase chain reaction (PCR). PCR was followed by restriction fragment length polymorphism and direct sequencing. No inactivating mutations reported so far were identified in exons 6, 7, and 10 in women with POF and poor responders.
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FSH receptor gene mutations are not frequent in Greek patients with POF as is the case in the rest of the world except for cases with ovarian dysgenesis in Finland. Final Decision: no