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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Aged, Analysis of Variance, Ataxia Telangiectasia Mutated Proteins, Cell Cycle Proteins, Chi-Square Distribution, China, Coronary Angiography, Coronary Stenosis, DNA-Binding Proteins, Female, Gene Expression Regulation, Enzymologic, Gene Frequency, Genetic Predisposition to Disease, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Phenotype, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Protein-Serine-Threonine Kinases, RNA, Messenger, Risk Assessment, Risk Factors, Severity of Illness Index, Tumor Suppressor Proteins.
user
Is functional polymorphism rs189037 in the promoter region of ATM gene associated with angiographically characterized coronary stenosis? Context: To evaluate the association between the single nucleotide polymorphism rs189037 of the ataxia-telangiectasia mutated (ATM) gene and angiographically characterized coronary stenosis as well as the molecular basis of this association. In 562 patients treated at the Department of Cardiology, West China Hospital, a significant association was found between polymorphism rs189037 and angiographically characterized coronary stenosis. For the T versus C allele, the adjusted OR was 0.79 (95%CI 0.67-0.92, P=0.003), using the allele frequency model; for TT versus CT/CC, the adjusted OR was 0.36 (95%CI 0.21-0.59, P=0.00006), using the recessive model; and for TT/CT versus CC, the adjusted OR was 0.54 (95%CI 0.29-1.02, P=0.06), using the dominant model. An antagonism was found between polymorphism rs189037 and diabetes mellitus (P=0.003). In coronary artery disease (CAD) patients, the TT genotype of rs189037 was associated with higher ATM mRNA expression (F=4.23, P=0.02) in peripheral mononuclear cells than the CC or CT genotypes.
assistant
Polymorphism rs189037 may influence the expression of ATM mRNA in CAD patients. It is also associated with the degree of coronary stenosis. Moderately low expression of the ATM gene may be associated with the development of coronary atherosclerosis. Final Decision: yes