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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Animals, Cystic Fibrosis, Disease Models, Animal, Enzyme Activation, Iodide Peroxidase, Liver, Male, Mice, Mice, Inbred CFTR, Triiodothyronine.
user
Is hepatic iodothyronine deiodinase type 1 activity decreased in two DeltaF508 cystic fibrosis mouse models? Context: Abnormal thyroid status has been reported in cystic fibrosis (CF) patients, and this can possibly be correlated to neuromuscular symptoms. Iodothyronine deiodinase type 1 (D1) activity is an important determinant of thyroid status, and we chose to investigate D1 activity in CF liver. We have measured hepatic D1 activities in two DeltaF508 CF mouse models. Hepatic D1 activity was significantly reduced by 31% to 48% in homozygous DeltaF508 mice compared with wild-type genotypes.
assistant
A decreased hepatic D1 activity could be the biochemical basis of some of the abnormal thyroid parameters observed in cystic fibrosis patients. Final Decision: yes