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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: .
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Do polcalcins from different pollen sources show different IgE reactivity? Context: Polcalcins are highly cross-reacting pollen panallergens able to sensitize less than 10% of allergic patients. All pollen species are considered able to sensitize patients to this panallergen. We aimed to assess the presence of polcalcin in different pollen extracts for allergen immunotherapy. Sera from polcalcin reactors as well as rPhl p7 and rBet v 4 were checked in an ELISA inhibition assay, using the recombinant polcalcin as substrate and freshly prepared pollen extracts as inhibitors. All pollen extracts induced significant inhibition of IgE reactivity to rBet v 4 whereas only grass pollen extract induced a marked inhibition of IgE reactivity to rPhl p 7.
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Grass polcalcin probably contains more epitopes than polcalcins from other pollen sources. Grass pollen could be responsible for sensitization to polcalcin and grass pollen immunotherapy is likely to be an option for polcalcin hypersensitive patients. Final Decision: yes