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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Apoptosis, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, Oligodeoxyribonucleotides, Antisense, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins c-myc, STAT3 Transcription Factor, bcl-2-Associated X Protein.
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Does [ Stat3 antisense oligodeoxynucleotide induce apoptosis in laryngeal carcinoma cells by regulating apoptosis-related factors ]? Context: To study the mechanism of apoptosis in laryngeal carcinoma cell induced by Stat3 antisense oligodeoxynucleotide (ASODN). The designed Stat3 ASODN was transferred into laryngeal carcinoma Hep-2 cell by lipofection. Expression of Bcl-2, Bax and C-Myc were detected by Western blot and PCR. Western blot and PCR results demonstrated that Stat3 ASODN could significantly increased the expression of Bax and decreased the expression of Bcl-2 and C-Myc when the concentration of antisense oligodeoxynucleotide were heightened.
assistant
Stat3 ASODN participate in apoptosis by enhancing the expression of Bax and reducing the expression of Bcl-2 and C-Myc. Final Decision: yes