system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Acinar Cells, Animals, Caffeine, Calcium, Cell Death, Cells, Cultured, Ceruletide, Cyclic AMP, Cyclic GMP, Cytosol, Ethanol, Fatty Acids, Monounsaturated, Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Male, Mice, Microscopy, Confocal, Mitochondria, Necrosis, Pancreas, Pancreatitis, Phosphodiesterase Inhibitors, Signal Transduction, Taurolithocholic Acid, Xanthines.
user
Does caffeine protect against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release? Context: Caffeine reduces toxic Ca Isolated pancreatic acinar cells were exposed to secretagogues, uncaged IP Caffeine, dimethylxanthines and non-xanthine PDE inhibitors blocked IP
assistant
Caffeine and its dimethylxanthine metabolites reduced pathological IP Final Decision: yes