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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Alveolar Bone Loss, Biomarkers, Chronic Periodontitis, Female, Gingival Crevicular Fluid, Gingival Hemorrhage, Humans, Interleukin-33, Interleukins, Male, Middle Aged, Periodontal Attachment Loss, Periodontal Index, Periodontal Pocket, Periodontium, Radiography, Bitewing, Saliva.
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Do interleukin-33 levels in gingival crevicular fluid , saliva , or plasma differentiate chronic periodontitis? Context: This study investigates whether gingival crevicular fluid (GCF), saliva, and plasma levels of interleukin-33 (IL-33) can differentiate individuals with chronic periodontitis from individuals with healthy periodontium. GCF, whole saliva, and plasma samples together with full-mouth clinical periodontal recordings were obtained from 32 otherwise healthy, non-smoker chronic periodontitis individuals and 25 systemically and periodontally healthy, non-smoker individuals. IL-33 levels in the biofluid samples were determined by enzyme-linked immunosorbent assay. Data were tested statistically by Mann-Whitney U test. The GCF concentrations of IL-33 were significantly lower in chronic periodontitis individuals than in healthy individuals (P <0.0001), whereas the total amounts in GCF samples were similar (P >0.05). The salivary and plasma contrations of IL-33 were indifferent in the two study groups (P >0.05).
assistant
According to the present findings, the GCF, saliva or plasma levels of IL-33 could not differentiate chronic periodontitis individuals and periodontally healthy individuals. Larger-scale intervention studies may better clarify this issue. Final Decision: no