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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Acantholysis is:
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The correct answer is  Ans. (b) Separation of keratinocytesRef: Harrison 19th ed. / 370* Keratinocytes are connected to one another by intracellular desmosomal bridges.* If there is loss of these desmosomal bridges, it will lead to separation of keratinocytes and the condition is known as acantholysis.* If separation continues, there will be intracellular edema, and the condition is known as Ballooning.Also Know* Degeneration of stratum basale is seen in: Lichen planus* Acanthosis: thickening of stratum spinosum* Hypergranulosis: Thickening of stratum granulosum* Hyperkeratosis: Thickening of stratum corneum* Parakeratosis: persistence of nucleus in stratum corneum layer