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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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A 69-year-old man presents to the emergency department with shortness of breath that has been worsening over the past month. The patient states that he has had worsening shortness of breath that has progressed to shortness of breath with simple activities and minor exertion. When he was unable to climb the stairs to his house today, he decided to come to the emergency department. The patient has a past medical history of poorly managed diabetes mellitus, hypertension, end stage renal disease, and obesity. His current medications include insulin, metformin, lisinopril, hydrochlorothiazide, and ibuprofen. The patient is notably non-compliant with his medications. An EKG and chest radiograph are normal. The patient had dialysis two days ago and attends most of his appointments. Laboratory values are ordered and are seen below:

Serum:
Na+: 135 mEq/L
K+: 4.5 mEq/L
Cl-: 100 mEq/L
HCO3-: 19 mEq/L
Urea nitrogen: 29 mg/dL
Glucose: 75 mg/dL
Creatinine: 2.5 mg/dL
Ca2+: 9.2 mg/dL
Mg2+: 1.7 mEq/L
AST: 11 U/L
ALT: 11 U/L

Leukocyte count and differential:
Leukocyte count: 4,500/mm^3
Platelet count: 150,000/mm^3
Neutrophil: 54%
Lymphocyte: 25%
Monocyte: 3%
Eosinophil: 1%
Basophil: 1%

Hemoglobin: 8.2 g/dL
Hematocrit: 22%
Mean corpuscular volume: 82 µm^3

The patient appears comfortable at rest but demonstrates notable shortness of breath when exerting himself. His temperature is 99.5°F (37.5°C), pulse is 89/min, blood pressure is 144/85 mmHg, respirations are 10/min, and oxygen saturation is 97% on room air. Pulmonary and cardiac exam are within normal limits. Which of the following is a side-effect of the long-term therapy this patient should be started on right now?
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Hypertension