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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Absorptiometry, Photon, Adult, Body Fat Distribution, Cohort Studies, Diabetes, Gestational, Female, Follow-Up Studies, Glucose Intolerance, Glucose Tolerance Test, Humans, Insulin Resistance, Insulin-Secreting Cells, Intra-Abdominal Fat, Middle Aged, Prediabetic State, Pregnancy, Prospective Studies, Risk Factors.
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Is β-cell dysfunction in women with previous gestational diabetes associated with visceral adipose tissue distribution? Context: Glucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes. The aim of the study was to evaluate glucose metabolism in women with and without gestational diabetes mellitus (GDM) at 5 years follow-up and identify risk factors associated with disturbed glucose metabolism post-partum. This follow-up study included 300 consecutively enrolled women from a previous population-based cohort study. The participants underwent oral glucose tolerance test under pregnancy and in the follow-up study, in addition to dual-energy X-ray absorptiometry in the follow-up study. Fifty-two women (17.7%) were found to have GDM in pregnancy with an odds ratio of 4.8 developing prediabetes 5 years later. β-cell function, but not insulin resistance or sensitivity, was reduced in the follow-up study after adjusting for known risk factors. Furthermore, visceral fat content at follow-up was increased in GDM women compared to non-GDM women, and the β-cell function declined with increasing visceral fat in both groups but was more pronounced in the women with previous GDM.
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Women with GDM are at increased risk of developing prediabetes and have a decreased β-cell function 5 years post-partum that is associated with increased visceral fat mass. Final Decision: yes