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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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The most significant adverse effect of ACE inhibition is
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The correct answer is  On initiation of therapy ACE inhibitors may cause significant hypotension -first dose phenomenon. Hence treatment should be staed with small doses and if patients are on diuretic it is temporarily stopped. Hyperkalemia is another side effect. Ref: KD tripathi 8th ed Page no 129