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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Anesthesia, Obstetrical, Anesthesia, Spinal, Anti-Anxiety Agents, Blood Pressure, Carbon Dioxide, Cesarean Section, Crystalloid Solutions, Elective Surgical Procedures, Female, Fetal Blood, Heart Rate, Humans, Hydrogen-Ion Concentration, Hypotension, Isotonic Solutions, Nausea, Ondansetron, Partial Pressure, Phenylephrine, Pregnancy, Preoperative Care, Vasoconstrictor Agents, Young Adult.
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Does ondansetron preloading with crystalloid infusion reduce maternal hypotension during cesarean delivery? Context: The aim of the article was to investigate the effect of ondansetron preloading with crystalloid infusion after spinal anesthesia during cesarean delivery. A total of 66 parturient women scheduled for elective caesarean sections were randomly assigned to two groups. Five minutes before spinal anesthesia, Group O patients were injected with 4 mg of ondansetron, while Group S patients were injected with 5 mL physiological saline. Maternal blood pressure and heart rate were measured at 2 minute intervals for 30 minutes. After delivery, umbilical cord blood samples were analyzed. Maternal hypotension and nausea were significantly lower in ondansetron-treated patients versus placebo (p = 0.011 vs. 0.004). Umbilical venous pH was significantly higher in ondansetron-treated patients (p = 0.006), while partial pressure of carbon dioxide (Pco 2) was significantly lower (p = 0.002). Decreases in maternal systolic and mean arterial blood pressures were significantly lower in ondansetron-treated patients (p = 0.008 vs. 0.025), with less requirement for phenylephrine administration compared with controls (p = 0.029).
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Ondansetron preloading combined with crystalloid infusion significantly reduced hypotension and nausea, while improving acid-base status, as well as reducing vasoconstrictor use. Final Decision: yes