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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Bone Morphogenetic Protein 2, Bone Morphogenetic Proteins, Bone Regeneration, Calcification, Physiologic, Collagen, Female, Male, Mandible, Osteogenesis, Osteogenesis, Distraction, Rabbits, Radiography, Recombinant Proteins, Transforming Growth Factor beta.
user
Does [ Recombinant human BMP-2 accelerate bone formation of mandibular distraction osteogenesis in rabbits ]? Context: To study the effects of rhBMP-2 on bone formation of mandibular distraction osteogenesis in rabbits. Bilateral mandibular osteotomies were performed in 12 mature rabbits. 5 mg rhBMP-2 with the collagen carrier was implanted in the osteotomy site of one side of the mandibles. Only the collagen sponge was placed in the contra-lateral side as control. The mandibles of 8 rabbits were lengthened by 6mm using a custom-made distractor. At 4 weeks after the end of distraction, all animals were killed and the distracted calluses were harvested and processed for histological, scanning electron microscopic, as well as Ca/P ratio analysis. The regenerated bone was found in the distraction gap after mandibular lengthening. The mandibular side treated with rhBMP-2 had greater amounts of new bone formation and earlier mineralization than contra-lateral side (non-rhBMP-2 treated).
assistant
Recombinant human BMP-2 appears to be able to accelerate bone formation of mandibular distraction osteogenesis in rabbits. Final Decision: yes