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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: PATIENTS AND METHODS, RESULTS. Meshes: Aged, Anti-Infective Agents, Combined Modality Therapy, Cutaneous Fistula, Female, Humans, Incidence, Laryngeal Neoplasms, Laryngectomy, Male, Metronidazole, Middle Aged, Neoplasm Staging, Pharyngeal Diseases, Postoperative Complications, Risk Factors.
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Pharyngocutaneous fistula complicating laryngectomy: can metronidazole help? Context: Seventy patients who underwent total laryngectomy between 2000 and 2008 in our department were divided into two groups. The first group (M+ group) was placed on a 10-day metronidazole regimen (2 days prior to surgery and 7 days following). The second group (M- group) received only regular preoperative chemoprophylaxis. In total, 17 (24.3%) incidents of PCF were reported, 3 of which were in the M+ group, with the remainder in the M- group. A statistically significant reduction in the PCF rate was noted in favor of metronidazole in the overall population (p = 0.005), as well as in the patient group that had received radiotherapy prior to surgery (p = 0.03).
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Metronidazole administered for a total of 10 days pre- and postoperatively seems to lower the incidence rate of PCF formation.