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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Family Health, Female, Finland, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Odds Ratio, Risk Assessment, Risk Factors, Surveys and Questionnaires, Varicose Veins.
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Is effect of family history on the risk of varicose veins affected by differential misclassification? Context: We assessed differential misclassification in self-reported family history of varicose veins by comparing consistency of subject's own varicose vein status and the consistency of information on varicose veins in family members. A population-based cohort study of 4,903 middle-aged residents of the city of Tampere, Finland. A questionnaire was used at entry and at the end of the 5-year follow-up. The estimated prevalence of positive family history of varicose veins varied depending on subject's own varicose veins from odds ratio (OR) 0.14 (95% confidence interval [CI]=0.01-0.58), in those with varicose veins reported in the first but not the second survey to OR 6.0 (95% CI=2.0-47.8), in those with varicose veins reported in the second survey but not in the first. The incidence of varicose veins varied from 0.4 (95% CI=0.1-1.4) to 4.1 (95% CI=2.1-7.1) (per 100 person-years) depending how the proband memorized the family history.
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Results on the effect of family history on varicose veins are subject to bias, which reduces the credibility of the reports proposing a strong hereditary component of varicose veins. Final Decision: yes