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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Arthritis, Juvenile, Case-Control Studies, Genetic Predisposition to Disease, Genotype, Granzymes, Haplotypes, Humans, Lymphohistiocytosis, Hemophagocytic, Macrophage Activation, Membrane Proteins, Perforin, Polymorphism, Single Nucleotide, Pore Forming Cytotoxic Proteins, Risk Factors, rab GTP-Binding Proteins, rab27 GTP-Binding Proteins.
user
Do genetic loci contributing to hemophagocytic lymphohistiocytosis confer susceptibility to systemic-onset juvenile idiopathic arthritis? Context: To investigate whether single-nucleotide polymorphisms (SNPs) within the genes PRF1, GZMB, UNC13D, and Rab27a, which are involved in natural killer cell dysfunction and known to contribute to the risk of hemophagocytic lymphohistiocytosis (HLH), confer an increased risk of susceptibility to systemic-onset juvenile idiopathic arthritis (JIA). Four SNPs across the PRF1 gene locus, 5 for GZMB, 7 for UNC13D, and 11 for Rab27a were investigated using MassArray genotyping in 133 UK Caucasian patients with systemic-onset JIA and 384 ethnically matched unrelated control subjects. Additional control genotypes were accessed from the data generated by the Wellcome Trust Case Control Consortium. No significant association was found between any SNP within the 4 selected loci and systemic-onset JIA, by either single-point or haplotype analysis.
assistant
The results of this study demonstrate that genes involved in HLH do not confer a significant risk of association with systemic-onset JIA. Final Decision: no