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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Adenocarcinoma, Barrett Esophagus, Carcinoma in Situ, Cohort Studies, Esophageal Neoplasms, Esophagogastric Junction, Esophagoscopy, Humans, Mucous Membrane, Retrospective Studies.
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Is directional distribution of neoplasia in Barrett 's esophagus influenced by distance from the gastroesophageal junction? Context: Accurate endoscopic detection and staging are critical for appropriate management of Barrett's esophagus (BE)-associated neoplasia. Prior investigation has demonstrated that the distribution of endoscopically detectable early neoplasia is not uniform but instead favors specific directional distributions within a short BE segment; however, it is unknown whether the directional distribution of neoplasia differs with increasing distance from the gastroesophageal junction, including in patients with long-segment BE. To identify whether directional distribution of BE-associated neoplasia is influenced by distance from the gastroesophageal junction. Retrospective cohort study. Tertiary-care referral center. Patients with either short-segment or long-segment BE undergoing EMR. EMR. Directional distribution of BE-associated neoplasia stratified by distance from gastroesophageal junction. EMR was performed on 60 lesions meeting study criteria during the specified time period. Pathology demonstrated low-grade dysplasia in 22% (13/60), high-grade dysplasia in 38% (23/60), intramucosal (T1a) adenocarcinoma in 23% (14/60), and invasive (≥ T1b) adenocarcinoma in 17% (10/60). Directional distribution of lesions was not uniform (P < .001), with 62% of lesions (37/60) located between the 1 o'clock and 5 o'clock positions. When circular statistics methodology was used, there was no difference in the directional distribution of neoplastic lesions located within 3 cm of the gastroesophageal junction compared with ≥ 3 cm from the gastroesophageal junction.
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Single-center study may limit external validity. Final Decision: no