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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Cell Cycle, Cell Nucleus, DNA, Fungal, Fungal Proteins, Gene Expression Regulation, Fungal, Green Fluorescent Proteins, Luminescent Proteins, Recombinant Fusion Proteins, Ribosomal Proteins, Ribosomes, Sordariales.
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Does in vivo labelling of functional ribosomes reveal spatial regulation during starvation in Podospora anserina? Context: To date, in eukaryotes, ribosomal protein expression is known to be regulated at the transcriptional and/or translational levels. But other forms of regulation may be possible. Here, we report the successful tagging of functional ribosomal particles with a S7-GFP chimaeric protein, making it possible to observe in vivo ribosome dynamics in the filamentous fungus Podospora anserina. Microscopic observations revealed a novel kind of ribosomal protein regulation during the passage between cell growth and stationary phases, with a transient accumulation of ribosomal proteins and/or ribosome subunits in the nucleus, possibly the nucleolus, being observed at the beginning of stationary phase.
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Nuclear sequestration can be another level of ribosomal protein regulation in eukaryotic cells. This may contribute to the regulation of cell growth and division. Final Decision: yes