system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE. Meshes: Acrosome Reaction, Adenylyl Cyclase Inhibitors, Adult, Animals, Chloride Channels, Chlorides, Contraceptive Agents, Male, Cricetinae, Cyclic AMP, Egg Proteins, Enzyme Inhibitors, Female, Fertilization, Humans, Hydrazines, Indazoles, Male, Membrane Glycoproteins, Membrane Transport Modulators, Phosphodiesterase Inhibitors, Phosphorylation, Protein Processing, Post-Translational, Receptors, Cell Surface, Recombinant Proteins, Sperm Capacitation, Spermatozoa, Zona Pellucida Glycoproteins.
user
Is inhibition of sperm capacitation and fertilizing capacity by adjudin mediated by chloride and its channels in humans? Context: Does adjudin disrupt chloride ion (Cl⁻) ion transport function in human sperm and impede sperm capacitation and fertilizing ability in vitro?
assistant
In this study the results indicate that adjudin is a potent blocker of Cl⁻ channels: disrupting Cl⁻ ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro. Final Decision: yes