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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, DESIGN, PATIENTS, INTERVENTIONS, MEASUREMENTS AND RESULTS. Meshes: APACHE, Blood Gas Analysis, Female, Humans, Intensive Care Units, Male, Middle Aged, Positive-Pressure Respiration, Predictive Value of Tests, Prone Position, Prospective Studies, Respiration, Respiratory Distress Syndrome, Adult, Time Factors.
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Is a short trial of prone positioning sufficient to predict the improvement in oxygenation in patients with acute respiratory distress syndrome? Context: To determine whether a 1-h trial of prone positioning is sufficient to identify responders. Prospective clinical cohort study in a medico-surgical ICU in a teaching hospital. 49 patients with acute respiratory distress syndrome. A 6-h period of prone positioning. Baseline measurements (blood gas analysis and respiratory parameters) were evaluated in supine position just prior to turning the patients prone. Measurements were then repeated 1 h after the beginning of prone positioning (PP1h) and at the end of the 6-h period of prone positioning (PP6h). The last measurements were performed 1 h after repositioning the patients supine. Prone position induced an increase in the PaO2/FIO2 ratio (p<0.001). A response (increase in PaO2/FIO2 ratio of at least 20 % at PP1h and/or at PP6h) was observed in 37 of 49 patients (76%). Twenty-seven of these patients (73%) were responders at PP1h while 10 (27%) were responders only at PP6h- In all, two-thirds of the patients were considered persistent responders. However, whereas the PaO2/FIO2 ratio decreased significantly 1 h after repositioning the fast responders supine, the PaO2/ FIO2 ratio remained unchanged after repositioning slow responders.
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A short-term trial of prone positioning does not appear a sufficient method to identify patients who would benefit from the postural treatment.