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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: 17-alpha-Hydroxyprogesterone, Adult, Algorithms, Drug Administration Schedule, Female, Fetal Membranes, Premature Rupture, Fetal Mortality, Gestational Age, Humans, Labor Stage, First, Mississippi, Pregnancy, Premature Birth, Statistics, Nonparametric, Young Adult.
user
Do women with preterm premature rupture of the membranes benefit from weekly progesterone? Context: We sought to determine if 17-alpha-hydroxyprogesterone (17P) extends gestation vs placebo in women with preterm premature rupture of the membranes (PPROM). Women with vertex presentations with PPROM, 20-30 weeks' gestation, were randomized to receive weekly 17P or placebo in an attempt to prolong the pregnancy. A total of 69 patients (17P, n = 33; placebo, n = 36) were randomized into this study. Initial cervical dilatation, gestational age at enrollment, and interval to delivery were not different between the 2 groups (P = .914, .424, and .146, respectively). Time of randomization to delivery (P = .250), mode of delivery (relative risk, 1.16; 95% confidence interval, 0.66-2.06), and the neonatal outcome statistics of morbidity (P = .820) and mortality (relative risk, 1.28; 95% confidence interval, 0.59-2.75) were similar between the 2 groups.
assistant
In patients with PPROM, 17P did not extend gestation vs placebo and cannot be recommended for treatment in such women. Final Decision: no