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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Animals, Antibodies, Antigens, Cell Line, Tumor, Corneal Neovascularization, Humans, Immunohistochemistry, Lymphangiogenesis, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Mice, Transgenic, Microscopy, Confocal, Neovascularization, Pathologic, Pericytes, Prostatic Neoplasms, Proteoglycans.
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Does targeting of pericytes diminish neovascularization and lymphangiogenesis in prostate cancer? Context: The walls of capillaries in prostate cancer are composed of endothelial cells, and pericytes. NG2 is a transmembrane proteoglycan on nascent pericytes with a functional role in neovascularization. The anti-angiogenic effect of hydron pellets containing NG2 neutralizing antibody was quantified in intracorneal PC-3 and LNCaP xenografts. TRAMP and TRAMP-C1 tumors grafted in NG2 knockout mice represented intrinsic pericyte targeting. TRAMP and TRAMP-C1 grafts were analyzed with confocal microscope for microvascular density (MVD) and lymphatic vascular density (LVD). NG2 neutralizing antibody decreased corneal neovascularization in PC3 (P<0.0001), and LNCaP (P=0.0079) xenografts. Mean MVD in TRAMP and TRAMP-C1 tumors in NG2 knockout mice were 71% (P=0.0006) and 63% (P=0.0011) lower than wild type controls, respectively. Mean LVD in TRAMP and TRAMP-C1 tumors in NG2 knockout mice were 73% (P=0.0003) and 84% (P<0.0001) lower than wild type controls, respectively.
assistant
Targeting of pericyte-NG2 decreases neovascularization and lymphangiogenesis in prostate cancer significantly. Final Decision: yes