system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, METHODS, METHODS, RESULTS. Meshes: Diphtheria-Tetanus-Pertussis Vaccine, Female, Guinea-Bissau, Hospital Mortality, Humans, Immunization Schedule, Infant, Male, Measles Vaccine, Sex Factors, Vaccination.
user
Is dTP with or after measles vaccination associated with increased in-hospital mortality in Guinea-Bissau? Context: The sequence of routine immunisations may be important for childhood mortality. Three doses of diphtheria-tetanus-pertussis vaccine (DTP) should be given at 6, 10, and 14 weeks and measles vaccine (MV) at 9 months of age. The sequence is not always respected. We examined in-hospital mortality of children having received DTP with or after measles vaccine. The only paediatric ward in Bissau, Guinea-Bissau. Children hospitalised during two periods in 1990-1996 and 2001-2002 who had received MV prior to hospitalisation. The all-cause case fatality at the hospital for children aged 6-17 months. The case fatality was increased for children who had received DTP with or after measles vaccine compared with children who had received measles vaccine as the most recent vaccine, the ratio being 2.53 (1.37-4.67) and 1.77 (0.92-3.41) in the two periods, respectively. The combined estimate was 2.10 (1.34-3.28). These results were not explained by differences in nutritional status, number of doses of DTP or discharge policy.
assistant
Administration of DTP with, or after MV, may reduce the beneficial effect of MV. Final Decision: yes