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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Anaerobiosis, Animals, Carbon Dioxide, Extracorporeal Membrane Oxygenation, Fluorocarbons, Hematocrit, Hydroxyethyl Starch Derivatives, Lactic Acid, Male, Oxygen, Partial Pressure, Pyruvic Acid, Rabbits.
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Do high oxygen delivery and extraction by perfluorocarbon-primed extracorporeal membrane oxygenation prevent anaerobic metabolism in rabbits? Context: This study was designed to evaluate the advantage of perfluorocarbon (PFC) emulsion priming for venoarterial extracorporeal membrane oxygenation (ECMO) by comparison with hydroxyethyl starch (HES) solution in rabbits (2.8 to 3.9 kg). ECMO initiation was accompanied by a profound decrease in hematocrit (from 40.1% to 14.9%) in both groups. The arterial and the right atrial oxygen contents in the PFC group (n = 4; 38.5 and 11.5 mL/dL) were greater than in the HES group (n = 5; 7.0 and 5.1 mL/dL). Right atrial oxygen tension in the PFC group increased at the beginning of ECMO (from 38.4 to 51.2 mm Hg; P = .031) and remained higher than in the HES group for 60 minutes. These results indicate that oxygen supply and extraction in the PFC group were much greater than in the HES group. However, plasma lactate increased progressively during the 120-minute ECMO procedure in both groups (from 1.8 to 14.5 in the HES group, and from 2.3 to 12.2 in the PFC group).
assistant
Perfluorocarbon priming for ECMO, although providing high oxygen delivery and extraction, does not prevent anaerobic metabolism. Final Decision: no