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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Human immunodeficiency virus (HIV) affects the immune response. The primary change brought about is:
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The correct answer is  HIV infects CD4 (helper) T-lymphocytes, macrophages and monocytes and leads to cell-mediated immune deficiency which predisposes to opportunistic infections and malignancies.