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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular, Cyclooxygenase 2, Disease Progression, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Liver Neoplasms, Male, Middle Aged, Prognosis, Receptors, Prostaglandin E, EP1 Subtype, Retrospective Studies, Treatment Outcome.
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Is cyclooxygenase-2 expression associated with initiation of hepatocellular carcinoma , while prostaglandin receptor-1 expression predicts survival? Context: To determine whether cyclooxygenase-2 (COX-2) and prostaglandin E1 receptor (EP We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma (HCC) who underwent surgery between 2008 and 2011 at our hospital. Expression of COX-2 and EP Factors associated with poor overall survival (OS) were alpha-fetoprotein > 400 ng/mL, tumor size ≥ 5 cm, and high EP
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COX-2 expression appears to be linked to early HCC events (initiation), while EP Final Decision: yes