system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A lady with secondary amenorrhea is negative for progesterone challenge test but positive for combined estrogen and progesterone challenge test. What is the probable cause:-
assistant
The correct answer is  PCOS has plenty estrogens but no progesterones, hence Progesterone therapy will elicit a withdrawal bleeding Asherman Syndrome is Endometrial Fibrosis, hence no estrogen or progesterone will show any effect In Pregnancy , if Estrogen and progesterones are given, it will not cause a withdrawal since the patient herself is making adequate amount of those hormones. Only ovarian failure or an Hypothalamic failure will be positive for combined estrogen and progesterone challenge test.