system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 30-year-old woman presents to the office with chief complaints of skin pigmentation and fragility of the extensor sides of both hands for a month. The lesions are progressive and are not directly sensitive to light. The patient is otherwise healthy and only uses an oral contraceptive. There is no skin disease or similar skin symptoms in family members. She consumes 1 glass of wine twice a week. Dermatological examination reveals erosions, erythematous macules, pigmentation, and atrophic scarring. Blood analysis reveals elevated CRP (34 mg/L), AST (91 U/L), ALT (141 U/L), and serum ferritin (786 ng/mL compared to the normal value of 350 ng/mL). Her BMI is 21 kg/m2. Urine porphyrin test results are negative. Autoimmune laboratory analysis, hepatic panel, and HIV serology are negative with a normal liver ultrasound. Genetic analysis shows a homozygous missense mutation of the HFE gene. What could be the long-term effect of her condition to her liver?
assistant
Hepatocellular carcinoma