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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adrenal Cortex Hormones, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Daclizumab, Dose-Response Relationship, Drug, Drug Combinations, Humans, Immunoglobulin G, Immunosuppressive Agents, Kidney Transplantation, Mycophenolic Acid, Tacrolimus.
user
Is tacrolimus dose requirement in renal transplant recipients significantly higher when used in combination with corticosteroids? Context: To evaluate the effect of corticosteroids on tacrolimus pharmacokinetics. In a randomized trial, kidney transplant recipients were treated with tacrolimus and mycophenolate mofetil with either daclizumab (n = 31) or 3 months of prednisone (n = 34). Tacrolimus dose-adjusted predose concentrations (C0) at month 1-6 were compared between both groups and within the corticosteroid group before and after prednisone withdrawal. At month 1 the tacrolimus dose-adjusted C0 in the corticosteroid group was 83 +/- 8 vs 119 +/- 17 ng ml-1 mg-1 kg-1 in the daclizumab group. The tacrolimus dose-adjusted C0 within the corticosteroid group at month 1 and 2 was 42% and 29% lower compared with month 4 (P < 0.001).
assistant
A higher tacrolimus dose is required to reach target concentrations when used in combination with corticosteroids. Final Decision: yes