system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Earliest sign of rickets is __________
assistant
The correct answer is  Most manifestations of rickets are a result of skeletal changes , Craniotabes is a softening of the cranial bones and can be detected by applying pressure at the occiput or over the parietal bones. T he sensation is similar to the feel of pressing into a ping-pong ball and then releasing. Craniotabes may also be secondary to osteogenesis imperfecta, hydrocephalus, and syphilis. Ref.nelson 20th edition page 339 nutrition chapter