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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Adipocytes, Adipose Tissue, Animals, Biological Transport, Cell Nucleus, Cells, Cultured, Chemokine CCL2, Estradiol, Estrogen Receptor Antagonists, Estrogen Receptor alpha, Estrogens, Female, Inflammation, Lipopolysaccharides, NF-kappa B, Obesity, Phosphorylation, Pyrrolidines, RNA, Small Interfering, Rats, Sprague-Dawley, Thiocarbamates, Transcription Factor RelA, p38 Mitogen-Activated Protein Kinases.
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Does oestrogen exert anti-inflammation via p38 MAPK/NF-κB cascade in adipocytes? Context: Oestrogen has anti-inflammatory property in obesity. However, the mechanism is still not defined. To investigate the effect of oestrogen on LPS-induced monocyte chemoattractant protein-1 (MCP-1) production in adipocytes. Lipopolysaccharides (LPS) was used to imitate inflammatory responses and monocyte chemotactic protein-1 (MCP-1) was selected as an inflammatory marker to observe. 17β-Estradiol (E LPS-induced MCP-1 largely impaired by pre-treatment with E
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E Final Decision: yes