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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Imipenem is combined with cilastatin to
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The correct answer is  Imipenems rapidly inactivated by renal dehydropeptidase I, so it is combined with cilastatin, an inhibitor of this enzyme. Cilastatin, a reversible inhibitor of dehydropeptidase, increases the half life of imipenem and also inhibits the formation of nephrotoxic metabolite. Meropenem, doripenem and eapenemare not metabolized by renal dehydropeptidase