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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adrenergic Antagonists, Animals, Catheterization, Dogs, Electrophysiology, Enteric Nervous System, Female, Intestine, Small, Myoelectric Complex, Migrating, Postprandial Period, Receptors, Adrenergic, Rectum.
user
Does rectal distension inhibit postprandial small intestinal motor activity partially via the adrenergic pathway in dogs? Context: Rectal distension is known to induce numerous upper gastrointestinal symptoms. The aim of this study was to investigate the effects and mechanisms of rectal distension on small intestinal myoelectrical and motor activities in 8 dogs using a pair of intestinal electrodes and an intestinal fistula. Experiment 1 entailed a 30-min baseline recording and a 30-min recording during rectal balloon distension at various volumes (60, 80, 100 and 120 ml) randomly. Experiment 2 comprised three sessions, each including a 30-min baseline recording, a 20-min recording after intravenous infusion of saline, phentolamine (3 mg/kg) or propranolol (3 mg/kg), respectively, and another 30-min recording during rectal balloon distending. 1) Rectal distension resulted in reduced intestinal motility in a dose-dependent manner (r=0.68, p<0.001). 2) The reduction in intestinal motility was significantly diminished when infusions of phentolamine (2.7+/-1.0 versus 8.4+/-1.5, p<0.01) or propranolol (3.7+/-1.4 versus 8.4+/-1.5, p<0.05) were given, suggesting partial involvement of the alpha- and beta-adrenergic pathways. 3) Rectal distension did not affect the percentage of normal 17-22 cycles/min intestinal slow waves (97.5+/-2.5 versus 93.0+/-5.3, p>0.05), or their dominant frequency (17.2+/-1.2 counts per minute (cpm) versus 17.7+/-1.0 cpm, p>0.05), or dominant power (-4.8+/-2.5 versus -8.2+/-2.9 dB, p>0.05).
assistant
Rectal distension inhibits postprandial small intestinal motor activity in a distension volume-dependent manner in dogs, and this inhibitory effect is at least partially mediated via the alpha and beta adrenergic pathways and does not involve any alterations in intestinal slow waves. Final Decision: yes