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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Follicular carcinoma of thyroid is mostly due to mutation of
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The correct answer is  Mutations in HRAS, KRAS, or more commonly NRAS occur in 25% of FTCs, 15% of PTCs (almost always the follicular variant of PTC), and 5% of follicular adenomas. Follicular thyroid is also associated with PAX8-PPARg. PAX8-PPARg appears to be confined to atypical follicular adenomas and FTC, and has not been detected in PTC or either poorly differentiated or undifferentiated (anaplastic) thyroid carcinomas RET and NTRK1 or more common in papillary thyroid cancer. Source : Devita principles of oncology 10th edition Pg: 1172