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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Arteries, Case-Control Studies, Female, Humans, In Vitro Techniques, Myometrium, Nitric Oxide, Pre-Eclampsia, Pregnancy, Receptor, Bradykinin B1, Receptor, Bradykinin B2, Vasodilation.
user
Is bradykinin B1 receptor-mediated vasodilation impaired in myometrial arteries from women with pre-eclampsia? Context: To investigate the vascular functional activity, localisation and expression of B1 and B2 kinin receptors in normal pregnancy and pre-eclampsia. Kinin receptor-mediated relaxation of myometrial arteries was assessed using wire myography. Immunohistochemical staining and gene expression of kinin receptors in the myometrium was determined. B2 receptor-mediated relaxation was reduced in pre-eclampsia. B1 receptor-mediated relaxation was observed in a proportion of healthy women and was impaired in pre-eclampsia. Receptor expression and localisation was unaltered in pre-eclampsia.
assistant
Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia. Final Decision: yes