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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Animals, Atrial Natriuretic Factor, Catheterization, Central Venous, Central Venous Pressure, Energy Intake, Fat Emulsions, Intravenous, Hypertension, Pulmonary, Linoleic Acid, Linoleic Acids, Natriuresis, Parenteral Nutrition, Total, Protein Precursors, Pulmonary Wedge Pressure, Swine, Time Factors.
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Does long term lipid-based parenteral nutrition cause pulmonary hypertension in pigs? Context: To study pulmonary perfusion after long term intravenous lipid-based total parenteral nutrition (TPN). Open experimental study. Teaching hospital, Norway. 31 pigs. Infusion of TPN alone, TPN + pellets, or Ringer's solution alone through central venous catheters for 7 weeks. Haemodynamic variables during a standardised volume load, and measurement of plasma N-terminal pro-atrial natriuretic factor (ANF). Mean pulmonary artery pressure (PAP) was 12.9 (6.1) to 20.1 (3.0) mmHg in response to the volume load in control animals compared with 15.8 (8.5) to 25.4 (5.8) (p < 0.05) mmHg in those given TPN alone and 22.8 (10.3) (p < 0.05) to 28.0 (6.4) (p < 0.05) mmHg in those given TPN and pellets. Pulmonary vascular resistance index was also increased after TPN, but the plasma N-terminal pro-ANF concentration did not increase during infusion of TPN.
assistant
Long term TPN caused moderate pulmonary hypertension, but not longstanding right-sided congestion. Final Decision: yes