system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Which anesthetic modality is to be avoided in sickle cell disease?
assistant
The correct answer is  Prevention of conditions that favor suckling is the basis of peri-operative management.

Supplemental oxygen is recommended during and after regional anesthesia/GA.
Circulatory stasis can be prevented with hydration and anticipation of intraoperative blood loss in order to avoid acute hypovolemia
Normothermia is desirable because hyperthermia increases the rate of gel formation, and hypothermia produces vasoconstriction that impairs organ blood flow.
The use of a tourniquet and hence Bier's block (intravenous regional anesthesia) is contraindicated because blood stasis can cause local acidosis, hypoxia with suckling of cells.
Drugs commonly used for anesthesia should not have significant effects on the suckling process.