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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, RESULTS. Meshes: Anti-Bacterial Agents, Anti-Inflammatory Agents, Dexamethasone, Drug Administration Schedule, Gentamicins, Humans, Otitis Media, Pseudomonas Infections, Pseudomonas aeruginosa, Staphylococcal Infections, Staphylococcus aureus.
user
Does dexamethasone alter in vitro antibacterial efficacy of gentamicin? Context: Aminoglycoside ototoxicity may be mitigated by administration of dexamethasone; however, dexamethasone could theoretically impair its antibacterial properties. The purpose of this experiment was to determine if dexamethasone decreases the antibacterial activity of gentamicin against Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA). In vitro microbiological assay. Four separate trials of minimum inhibitory concentration (MIC) testing were performed for gentamicin against five PA strains and six SA strains, with and without the addition of high and low concentrations of dexamethasone. MICs were not changed by more than one dilution with the addition of either high or low concentrations of dexamethasone for any of the PA and SA strains.
assistant
Dexamethasone does not impair the antibacterial efficacy of gentamicin for PA and SA. This supports the role of dexamethasone as an oto-protectant with aminoglycoside therapy. Final Decision: no