system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 30-year-old woman comes to the emergency department because of weakness and fatigue for 2 days. She has also noticed that her urine is darker than usual. For the past week, she has had a persistent non-productive cough and low-grade fever. She has seasonal allergies. She drinks one to two glasses of wine on social occasions and does not smoke. Her temperature is 37.9°C (100.2°F), pulse is 88/min, respirations are 18/min, and blood pressure is 110/76 mm Hg. She has conjunctival pallor and scleral icterus. Cardiopulmonary examination shows bibasilar crackles. The remainder of the physical examination shows no abnormalities. Laboratory studies show:
Leukocyte count 8,000/mm3
Hemoglobin 7.1 g/dL
Hematocrit 21%
Platelet count 110,000/mm3
MCV 94 μm3
Serum
Total bilirubin 4.3 mg/dL
Direct 1.1 mg/dL
Indirect 3.2 mg/dL
AST 15 U/L
ALT 17 U/L
LDH 1,251 U/L
Haptoglobin 5.8 mg/dL (N = 41–165)
An x-ray of the chest shows bilateral patchy infiltrates. A peripheral blood smear shows spherocytes. Which of the following is most likely to confirm the diagnosis?"
assistant
Direct Coombs test