system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Amyotrophic Lateral Sclerosis, Cohort Studies, Electromyography, Evoked Potentials, Motor, Female, Humans, Male, Middle Aged, Motor Cortex, Motor Neurons, Muscle, Skeletal, Prospective Studies, Transcranial Magnetic Stimulation.
user
Does cortical hyperexcitability precede lower motor neuron dysfunction in ALS? Context: To determine whether cortical hyperexcitability preceded the development of lower motor neuron (LMN) dysfunction in sporadic amyotrophic lateral sclerosis (ALS). Cortical excitability studies were undertaken in 24 ALS patients with motor evoked potential (MEP) recorded over the abductor pollicis brevis (APB) muscle. In the same sitting, LMN function of the target APB muscle was assessed utilising qualitative and quantitative electromyography techniques along with axonal excitability studies. At time of assessment, the anatomical and functional integrity of the lower motor neuronal circuits innervating the target APB muscle was preserved in all patients, confirmed by a normal CMAP amplitude (P=0.37), absence of fasciculations, or features of neurogenic change. Despite this apparent 'normality' cortical dysfunction was evident, with significant reduction of short interval intracortical inhibition (P<0.01), resting motor threshold (P<0.05) and cortical silent period duration (P<0.001), along with increases in MEP amplitude (P<0.05) and intracortical facilitation (P<0.05).
assistant
The findings in the present study suggest that cortical hyperexcitability occurs upstream to a seemingly intact lower motor neuronal system. Final Decision: yes