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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, UNASSIGNED, RESULTS. Meshes: Adult, Cell Line, Female, Fetal Blood, Human Umbilical Vein Endothelial Cells, Humans, Infant, Newborn, Maternal-Fetal Exchange, Mothers, Pregnancy, Pregnancy Complications, Serotonin, Vitamin D, Vitamin D Deficiency, Young Adult.
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Is maternal 25-hydroxyvitamin D inversely correlated with fetal serotonin? Context: Maternal vitamin D deficiency during pregnancy has been linked to impaired neurocognitive development in childhood. The mechanism by which vitamin D affects childhood neurocognition is unclear but may be via interactions with serotonin, a neurotransmitter involved in fetal brain development. In this study we aimed to explore associations between maternal and fetal vitamin D concentrations, and fetal serotonin concentrations at term. Serum 25-hydroxyitamin D (25(OH)D, nmol/L) and serotonin (5-HT, nmol/L) concentrations were measured in maternal and umbilical cord blood from mother-infant pairs (n=64). Association between maternal 25(OH)D, cord 25(OH)D and cord serotonin was explored using linear regression, before and after adjusting for maternal serotonin levels. We also assessed the effects of siRNA knockdown of the vitamin D receptor (VDR) and administration of 10nM 1,25-dihydroxyvitamin D We observed an inverse relationship between both maternal and cord 25(OH)D concentrations with cord serotonin concentrations. The treatment of HUVECs with 1,25- dihydroxyvitamin D
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These observations provide the first evidence of an inverse relationship between maternal 25(OH)D and fetal serotonin concentrations. We propose that maternal vitamin D deficiency increases fetal serotonin concentrations and thereby contributes to longer-term neurocognitive impairment in infants and children. This article is protected by copyright. All rights reserved. Final Decision: yes