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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: 8-Hydroxy-2-(di-n-propylamino)tetralin, Aged, Aged, 80 and over, Antidepressive Agents, Antiparkinson Agents, Autopsy, Cerebral Cortex, Dementia, Depression, Female, Humans, Levodopa, Lewy Body Disease, Male, Middle Aged, Parkinson Disease, Receptor, Serotonin, 5-HT1A, Serotonin Receptor Agonists, Temporal Lobe.
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Are cortical serotonin 1A receptor levels associated with depression in patients with dementia with Lewy bodies and Parkinson 's disease dementia? Context: Serotonin 1A receptors (5-HT(1A)) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression. To examine 5-HT(1A) in DLB and PDD postmortem in relation to depression. [(3)H]8-hydroxy-2-dipropylaminotetralin binding to 5-HT(1A) was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls. 5-HT(1A) density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20.
assistant
Higher BA36 5-HT(1A) density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT(1A) antagonist adjuvant may improve treatment of depression in dementia. Final Decision: yes