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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE. Meshes: Cell Line, Cells, Cultured, Endometrium, Endothelium, Vascular, Estrogen Receptor beta, Estrogens, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Microvessels, Myometrium, Nitriles, Organ Specificity, RNA Interference, RNA, Messenger, RNA, Small Interfering, Signal Transduction, Sp1 Transcription Factor, Umbilical Veins.
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Are eRβ-dependent effects on uterine endothelial cells cell specific and mediated via Sp1? Context: What are the in vitro effects of estrogen receptor β (ERβ) activation on the function of endothelial cells (ECs) from different vascular beds: human endometrial ECs (HEECs; endometrium), uterine myometrial microvascular ECs (UtMVECs; myometrium) and human umbilical vein ECs (HUVECs)?
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Studies conducted in vitro demonstrate that the ERβ agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) has EC type-specific effects on patterns of gene expression and network formation. Identification of a key role for the transcription factor Sp1 in ERβ-dependent signaling in uterine ECs offers new insights into cell-specific molecular mechanisms of estrogen action in the human uterus. Final Decision: yes