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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Female, Lysophospholipids, Mice, Mice, Nude, Neoplasm Invasiveness, Neoplasm Transplantation, Ovarian Neoplasms, Peritoneal Neoplasms, Random Allocation, Transplantation, Heterologous, Tumor Burden.
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Does [ Lysophosphatidic acid promote transplanted tumor growth of human epithelium ovarian cancer in nude mice ]? Context: To investigate effect of lysophosphatidic acid (LPA) on growth and metastasis of intraperitonally transplanted tumor in nude mice. Sixteen nude mice randomly divided into control group and LPA treatment group, in which 6x10(6) untreated and LPA-treated human ovarian cancer cells skov3 were respectively transplanted intraperitoneally. After death of the nude mice without interventions, the weight of the transplanted tumors and number of metastatic tumors were recorded. The rate of tumor formation was 100%in both groups, but the treatment group showed more rapid tumor growth, greater tumor weight and more numerous metastatic tumors than the control group (P<0.01).
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LPA simulates the growth and promotes invasiveness of transplanted ovarian cancer cells in the peritoneal cavity of nude mie. Final Decision: yes