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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Age Factors, Aged, Aged, 80 and over, Antibiotics, Antineoplastic, Delayed Diagnosis, Doxorubicin, Female, Hemangiosarcoma, Humans, Male, Palliative Care, Polyethylene Glycols, Radiotherapy, Adjuvant, Retrospective Studies, Skin Neoplasms.
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Is cutaneous angiosarcoma a rare aggressive malignant vascular tumour of the skin? Context: Cutaneous angiosarcoma (AS) is a rare aggressive malignant vascular tumour of the skin. We analysed the cases of cutaneous AS in two large dermatological departments of Saxony during the last 10 years. A total of eight AS cases were identified, mostly with head and neck involvement. Because of age and late diagnosis, only a minor part was completely resectable. As a palliative therapy pegylated liposomal doxorubicin was used. The drug was well tolerated. Our cases and those published in the literature suggest a high rate of responses and a possible sensitisation to subsequent radiation therapy.
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Although complete surgical resection followed by wide-field radiation therapy has been established as a therapeutic standard for AS, delay in diagnosis and older age with comorbidities warrant for a safe and effective adjuvant treatment. Pegylated liposomal doxorubicin combined with radiotherapy seems to be a useful and safe alternative. Final Decision: yes