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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
As compared with the early immunosuppressive drugs (azathioprine, steroids, anti-lymphocyte serum) some newer agents have the following specific advantages:
assistant
The correct answer is  Cyclosporine interferes with the production of cytokines and lacks the bone marrow toxicity of azathioprine. Unfounately, its chief toxicity is renal. Although OKT3 is more available, more uniform, and more specific than antilymphocyte serum, some of its side effects are even greater, such as fever, chills, nausea, vomiting, diarrhea, and pulmonary edema. Tacrolimus has been used most extensively for liver grafts. It has been found especially valuable in reversing rejection of failing grafts.