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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adolescent, Age of Onset, Alanine, Asthma, Case-Control Studies, Child, Child, Preschool, Genotype, Humans, Infant, Manganese, Mitochondria, Oxidative Stress, Peptides, Polymorphism, Genetic, Superoxide Dismutase, Valine.
user
Is the Ala-9Val polymorphism in the mitochondrial targeting sequence ( MTS ) of the manganese superoxide dismutase gene associated with juvenile-onset asthma? Context: We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma. Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV. No significant difference in genotype frequencies was found between patients and controls.
assistant
These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma. Final Decision: no