system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 32-year-old woman presents to her primary care provider complaining of a psoriatic flare that has worsened over the past 2 days. The patient states that her psoriasis is normally well-controlled. She also complains of some fatigue and states that she has recently developed pain and tenderness in the joints of her hands with the right hand being more tender than the left. Her hands are stiff in the morning, and sometimes her fingers swell up. She attributes these changes to her new job where she constantly uses her hands to manufacture cabinets. Physical exam reveals plaques with silvery scale on her elbows and knees. The distal joints of her right hand are mildly swollen and the nails on both hands appear pitted. What is the most likely pathogenesis of her joint pain?
assistant
Release of TNF and activation of RANKL pathway