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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Administration, Topical, Aged, Antimetabolites, Antineoplastic, Biomarkers, Tumor, Carcinoma in Situ, Carcinoma, Squamous Cell, Conjunctival Neoplasms, Fluorouracil, Humans, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Neoplasm Proteins, Tissue Inhibitor of Metalloproteinase-1.
user
Is therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression? Context: To evaluate matrix metalloproteinases (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 expression in a case of conjunctival intraepithelial squamous cell carcinoma (SCC) treated with topical 5-fluorouracil (5-FU) chemotherapy. Clinicopathologic case report. A 71-year-old male patient presented with an intraepithelial conjunctival SCC. Because of a recurrence, he was placed on topical 5-FU for 4 weeks that ultimately led to a complete resolution of the disease. Conjunctival biopsies, impression cytologies, and tear samples were taken from the mass and the contralateral healthy eye. An overexpression of MMP-2, MMP-9, and TIMP-1 was observed in the tumor by immunohistochemistry. Clinical resolution of the neoplasm obtained using topical 5-FU was accompanied by a reduction in the expression of MMP-2, MMP-9, and TIMP-1 in tears and dysplastic conjunctival epithelium.
assistant
In our case report, we have shown that gelatinase and TIMP-1 are unregulated in conjunctival SCC and can be monitored as a marker of response to topical chemotherapy. Further studies are required to define the role of MMPs in growth and resolution of ocular tumors. Final Decision: yes