system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Intravascular hemolysis causes -
assistant
The correct answer is  In G6PD defficiency both intravascular and extravascular hemolysis occurs. Here due to decreased synthesis of reduced glutathione ,when RBC exposed to oxidant stress H2O2 get accumulated ,damages RBC membrane causing hemolysis. It usually presents as acute self limited acute intravascular hemolytic anemia. Reference: Exam preparatory manual for undergraduates - Pathology by Ramdas Nayak page no :267 Ref Robbins 9/e pg 410