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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Antigens, CD, Antigens, Differentiation, T-Lymphocyte, Blood Cells, Embryo Implantation, Female, Fertilization in Vitro, Humans, Infertility, K562 Cells, Killer Cells, Natural, Lectins, C-Type, Lymphocyte Activation, Pregnancy, Pregnancy Outcome, Treatment Failure, Up-Regulation.
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Does peripheral blood natural killer cells activation status determined by CD69 upregulation predict implantation outcome in IVF? Context: NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present study, we investigate the significance of NK activation levels in predicting embryo implantation. A qualitative analysis of values distribution in two groups showed that 25/33 (75.8%) women who became pregnant had CD69(stim) levels that were >30 but <60% (conditionally normal zone). In contrast, CD69(stim) levels in patients who failed to become pregnant were either elevated, as in 10/51 (19.6%), or reduced, as in 20/51 (39.2%) of the patients. Accentuated CD69(stim) levels were predictive for implantation failure, extremely significant for decreased (OR 6.9, p=0.0004) and not quite significant for increased CD69(stim) levels (OR 3.9, p=0.062). Accordingly, conditionally normal CD69(stim) levels were favourable for implantation (OR 4.46, p=0.0032).
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We confirm that actual peripheral blood natural killer cells activation status have an influence on embryo implantation. We showed that exactly normal NK cell activity predicting successful implantation. Final Decision: yes