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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Cell Nucleus, Cyclin D1, Cytoskeletal Proteins, Endometrial Neoplasms, Endometrium, Female, Humans, Ki-67 Antigen, Middle Aged, Receptors, Estrogen, Receptors, Progesterone, Trans-Activators, beta Catenin.
user
Is nuclear localization of beta-catenin correlated with the expression of cyclin D1 in endometrial carcinomas? Context: beta-catenin has recently been reported to act as a cell growth promoter through cyclin D1 transcription. However, the correlation between beta-catenin and cyclin D1 expressions is not fully understood in endometrial tissues. Immunohistochemical expression of beta-catenin was examined in normal endometria (32 cases) and endometrial carcinomas (82 cases), and its expression was compared with that of cyclins (D1, E, A, B1). Sporadic nuclear staining of beta-catenin and cyclins was observed from proliferative phase of early secretory phase endometria, however, spacial correlations between beta-catenin and cyclins were not evident. In endometrial carcinomas, positivity for nuclear beta-catenin and cyclins increased compared to the normal endometria. Topologically, the cyclin D1-positive cells were frequently found in nuclear beta-catenin-positive cells. In addition, Spearman's rank correlation analysis revealed that the nuclear expression of beta-catenin correlated positively with that of cyclin D1 (p < 0.0001).
assistant
The beta-catenin-cyclin D1 pathway might be involved in the growth of endometrial carcinomas. Final Decision: yes