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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Body Composition, Body Mass Index, C-Reactive Protein, Chronic Disease, Cytokines, Diabetes Complications, Female, Humans, Hypertension, Inflammation, Kidney Failure, Chronic, Lung, Male, Malnutrition, Middle Aged, Muscle Weakness, Muscle, Skeletal, Pulmonary Ventilation, Renal Replacement Therapy, Respiratory Muscles, Serum Albumin.
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Is pulmonary dysfunction possibly a marker of malnutrition and inflammation but not mortality in patients with end-stage renal disease? Context: Various studies have indicated that malnutrition and chronic inflammation are strong predictors of morbidity and mortality in patients with chronic kidney disease (CKD). The purpose of this study was to investigate the relationship between pulmonary function, malnutrition and chronic inflammation in patients with CKD. One hundred and six consenting patients with CKD were enrolled in the study between 2005 and 2007. Pulmonary function was assessed by forced vital capacity (FVC), forced expiratory volume in the first second (FEV(1)) and peak expiratory flow (PEF), expressed as the normal percentage of predicted values (%FEV(1), %FVC and %PEF, respectively). Nutritional status was evaluated by skeletal muscle index (SMI), subjective global nutritional assessment (SGA), lean body mass, body mass index and serum albumin. Inflammation was assessed by the serum measurement of high-sensitive C reactive protein (hsCRP) levels. Malnutrition (defined as SMI > or =1) and inflammation (defined as hsCRP >2 mg/l) in ESRD patients had significant negative associations with percentage predicted values for pulmonary function tests except %PEF (SMI: %FEV(1), p = 0.009, %FVC, p = 0.001; hsCRP: %FEV(1), p = 0.025, %FVC, p = 0.022). Multivariate Cox analysis showed that the ejection fraction in echocardiography and SGA were associated with poor survival, but there was no association for %FEV(1).
assistant
Impaired pulmonary function was associated with malnutrition and inflammation in these dialysis patients. We were not able to determine a significant relationship between pulmonary function and mortality. Final Decision: yes