system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 36-year old pregnant woman (gravida 4, para 1) presents at week 11 of pregnancy. Currently, she has no complaints. She had an uncomplicated 1st pregnancy that ended in an uncomplicated vaginal delivery at the age of 28 years. Her male child was born healthy, with normal physical and psychological development over the years. Two of her previous pregnancies were spontaneously terminated in the 1st trimester. Her elder sister has a child born with Down syndrome. The patient denies smoking and alcohol consumption. Her blood analysis reveals the following findings:
  Measured values
Beta human chorionic gonadotropin (beta-hCG) High
Pregnancy-associated plasma protein-A (PAPP-A) Low
Which of the following is the most appropriate next step in the management of this patient?
assistant
Recommend chorionic villus sampling with subsequent cell culturing and karyotyping