system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 9-year-old girl is brought to the physician by her mother because of a 3-day history of face and foot swelling, dark urine, and a rash on her hands and feet. The mother reports that her daughter has had a low-grade fever, shortness of breath, and a dry cough for the past 8 days. She has had generalized weakness and pain in her right knee and ankle. She has a ventricular septum defect that was diagnosed at birth. The patient appears lethargic. Her temperature is 38.4 (101.1°F), pulse is 130/min, respirations are 34/min, and blood pressure is 110/60 mm Hg. Examination shows small, non-blanching, purple lesions on her palms, soles, and under her fingernails. There is edema of the eyelids and feet. Funduscopic examination shows retinal hemorrhages. Holosystolic and early diastolic murmurs are heard. Laboratory studies show:
Hemoglobin 11.3 g/dL
Erythrocyte sedimentation rate 61 mm/h
Leukocyte count 15,000/mm3
Platelet count 326,000/mm3
Urine
Blood 4+
Glucose negative
Protein 1+
Ketones negative
Transthoracic echocardiography shows a small outlet ventricular septum defect and a mild right ventricular enlargement. There are no wall motion abnormalities, valvular heart disease, or deficits in the pump function of the heart. Blood cultures grow Streptococcus pyogenes. Which of the following is the most likely diagnosis?"
assistant
Infective endocarditis