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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Alcoholism, Central Nervous System Depressants, Ethanol, Female, Folic Acid, Folic Acid Deficiency, Homocysteine, Humans, Hyperhomocysteinemia, Linear Models, Male, Middle Aged, Pyridoxine, Riboflavin, Substance Withdrawal Syndrome, Thiamine, Vitamin B 12, Vitamin B 12 Deficiency.
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Are alterations of homocysteine serum levels during alcohol withdrawal influenced by folate and riboflavin : results from the German Investigation on Neurobiology in Alcoholism ( GINA )? Context: Various studies have shown that plasma homocysteine (HCY) serum levels are elevated in actively drinking alcohol-dependent patients a during alcohol withdrawal, while rapidly declining during abstinence. Hyperhomocysteinemia has been associated not only with blood alcohol concentration (BAC), but also with deficiency of different B-vitamins, particularly folate, pyridoxine and cobalamin. Our study included 168 inpatients (110 men, 58 women) after admission for detoxification treatment. BAC, folate, cobalamin, pyridoxine, thiamine and riboflavin were obtained on admission (Day 1). HCY was assessed on Days 1, 7 and 11. HCY levels significantly declined during withdrawal. General linear models and linear regression analysis showed an influence of BAC, folate and riboflavin on the HCY levels on admission as well as on HCY changes occurring during alcohol withdrawal. No significant influence was found for thiamine, cobalamin and pyridoxine.
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These findings show that not only BAC and plasma folate levels, but also plasma levels of riboflavin influence HCY plasma levels in alcohol-dependent patients. Final Decision: yes