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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Female, Fetal Diseases, Gestational Age, Humans, Meningomyelocele, Obstetric Labor, Premature, Pregnancy, Retrospective Studies, Risk Factors.
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Does gestational age at intrauterine myelomeningocele repair influence the risk of prematurity? Context: To determine the effect of gestational age at the time of intrauterine myelomeningocele repair on the duration of pregnancy and the gestational age at the time of delivery. This study is a retrospective chart review of the maternal and neonatal medical records of all infants undergoing intrauterine myelomeningocele repair at Vanderbilt University Medical Center. Birth weight, gestational age at the time of surgery and gestational age at the time of delivery were recorded. Infants were divided into 2 groups depending on gestational age at the time of surgery, either > or = 25 weeks' gestation (group 1) or < 25 weeks (group 2). Results were expressed as medians and interquartile ranges. Statistical analysis was done using the unpaired (2-sample) t test; p values < or = 0.05 were considered significant. Ninety-five infants were studied. Fifty-one infants were repaired after 25 weeks' gestation (group 1) at a median gestational age of 26.3 weeks (range 25.6-27.6). Their median gestational age at delivery was 34.4 weeks (range 32.6-35.3). Forty-four infants were repaired before 25 weeks' gestation (group 2). Surgery was done at a median gestational age of 23.6 weeks (range 22.4-24.5). The median gestational age at delivery was 34 weeks (range 31.6-35.3; p = 0.88).
assistant
Early intrauterine myelomeningocele repair before 25 week's gestation does not decrease the gestational age at delivery when compared with repair after 25 weeks. Final Decision: no