system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Administration, Oral, Administration, Topical, Adult, Aged, Anticarcinogenic Agents, Bexarotene, Female, Humans, Lymphomatoid Papulosis, Male, Middle Aged, Palliative Care, Prospective Studies, Tetrahydronaphthalenes.
user
Is bexarotene a new treatment option for lymphomatoid papulosis? Context: Lymphomatoid papulosis (LyP) is a clonal T cell proliferation with large cell histology, a chronic course, and an increased risk of lymphoma. Bexarotene (Targretin) is an RXR-selective retinoid (rexinoid) approved for the cutaneous manifestations of cutaneous T cell lymphoma. To determine whether bexarotene is effective in treating LyP. Ten patients with chronic and symptomatic LyP were prospectively treated with oral (n = 3) or topical gel (n = 7) formulations of bexarotene. A favorable response to bexarotene treatment with decreased numbers or duration of lesions was seen in all with objective responses in 8 patients.
assistant
Bexarotene may be an effective palliative treatment for LyP, warranting further controlled studies. Final Decision: yes