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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Biomarkers, Body Mass Index, Chi-Square Distribution, Disease Progression, Down-Regulation, Female, Glomerular Filtration Rate, Humans, Hypoalbuminemia, Kidney, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Nutritional Status, Odds Ratio, Prospective Studies, Protein-Energy Malnutrition, Renal Dialysis, Renal Insufficiency, Chronic, Risk Factors, Serum Albumin, Serum Albumin, Human, Thinness, Time Factors, Tokyo.
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Is combination of low body mass index and serum albumin level associated with chronic kidney disease progression : the chronic kidney disease-research of outcomes in treatment and epidemiology ( CKD-ROUTE ) study? Context: The relationship between protein-energy wasting and chronic kidney disease (CKD) progression is unknown. In the present prospective cohort study, we evaluated the hypothesis that a combination of low body mass index (BMI) and serum albumin level is associated with rapid CKD progression. The study cohort comprised 728 predialysis Japanese patients with CKD (stages 2-5) enrolled from 2010 to 2011. Patients were categorized into four groups according to their serum albumin levels and BMI: group 1, low serum albumin level (<4 g/dL) and low BMI (<23.5 kg/m Logistic regression analysis adjusted for baseline characteristics (reference, group 4) showed that only group 1 was associated with a significant risk of CKD progression, with adjusted odds ratio of 3.51 [95 % confidence interval (CI) (1.63, 7.56)]. A multivariate linear regression analysis adjusted for baseline characteristics showed a significant difference in annual eGFR decline between groups 1 and 4 [coefficients β (standard error) -2.62 (0.75), p = 0.001].
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This study suggests that combined effects of low BMI (<23.5 kg/m Final Decision: yes