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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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True about the Sickle cell disease are all, Except -
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The correct answer is  Sticky patch in sickle cell disease results from replacement of a polar residue (Glutamate) with a nonpolar residue (Valine) at the 6th position of the beta chain.
Sickle cell anemia is caused by a point mutation, i.e. mutation of just one (single) nucleotide of DNA. The altered codon specifies a different amino acid (glutamic acid), and this causes a structural abnormality of the β-globin molecule.
Heterozygotes for the sickle cell mutation are more resistant to malarial infection because the erythrocytes of heterozygotes provides less favorable environment for plasmodium parasite.
RFLPs result from single-base changes (e.g. sickle cell disease) or from deletion or insertions of DNA into a restriction fragment (e.g. thalassemias).