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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS. Meshes: .
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Is missense mutation G296S in GATA4 responsible for cardiac septal defects? Context: The most common type of congenital heart disease is the cardiac septal defects, which has reported to be caused by a missense mutation (G296S) in exon 3 of the GATA4 gene. The present study was undertaken to find out whether GATA4 gene is the prime cause of the septal defects in Mysore population. GATA4 gene analyses were undertaken on 21 confirmed CHD cases by PCR and DNA sequencing.
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Analysis of this particular mutation in 21 septal defect patients revealed that none of the patients had the mutation, indicating that this mutation is population specific or septal defect in Mysore population is caused due to mutations in other regions of the GATA4 gene. Final Decision: no