system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 61-year-old woman presents to her primary care provider with complaints of fatigue, weight gain of 5.5 kg (12.1 lb) and intermittent nausea over the past 4 months. She denies any changes to her diet. She has had type 2 diabetes mellitus for the past 27 years complicated by diabetic neuropathy. Vital signs include: temperature 37.0°C (98.6°F), blood pressure 167/98 mm Hg and pulse 80/min. Physical examination reveals bilateral pitting lower-extremity edema. Fundoscopic examination reveals bilateral micro-aneurysms and cotton wool patches. Her serum creatinine is 2.6 mg/dL. Which of the following is the best initial therapy for this patient?
assistant
Perindopril