system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Aged, Area Under Curve, Biomarkers, Cardiac Output, Low, Cohort Studies, Cytokines, Echocardiography, Female, Humans, Logistic Models, Male, Middle Aged, Myocardial Infarction, Natriuretic Peptide, Brain, Patient Readmission, Peptide Fragments, Predictive Value of Tests, ROC Curve, Survival Analysis.
user
Does cardiotrophin-1 predict death or heart failure following acute myocardial infarction? Context: Cardiotrophin-1 (CT-1) is an important inflammatory cytokine; its presence has been documented in patients after acute myocardial infarction (AMI). However, its role as a predictor of death or heart failure is unclear. We sought to investigate this and compared it with N terminal pro-B-type natriuretic peptide (NT-proBNP), a marker of death or heart failure. We studied 291 post-AMI patients. The plasma concentration of CT-1 and NT-proBNP was determined using in-house noncompetitive immunoassays and patients followed for death or heart failure. There were 27 deaths and 19 readmissions with heart failure. CT-1 was raised in patients with death or heart failure compared with survivors (median [range] fmol/mL, 0.9 [0.1-392.2] vs. 0.67 [0-453.3], P = .019). Using a multivariate binary logistic model CT-1 (OR 1.8, 95% CI: 1.1-3.2, P = .031) and NT-proBNP (OR 2.4, 95% CI: 1.1-5.2, P = .026) predicted death or heart failure independently of age, sex, previous AMI, serum creatinine, and Killip class. The receiver-operating curve for CT-1 yielded an area under the curve (AUC) of 0.62 (95% CI: 0.53-0.70, P = .017); for NT-proBNP the AUC was 0.77 (95% CI: 0.69-0.86, P < .001); the logistic model combining the 2 markers yielded an AUC of 0.84 (95% CI: 0.78-0.91, P < .001).
assistant
After an AMI, combined levels of CT-1 and NT-proBNP are more informative at predicting death or heart failure than either marker alone. Final Decision: yes