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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Which of the following is the most important mediator implicated in development of fever:
assistant
The correct answer is  PGF2α is a vasoconstrictor whereas PGD2 and PGE2 are vasodilators. 
PGE2 is the most important chemical for development of fever.