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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Patient Safety, Radiation Dosage, Radiographic Image Interpretation, Computer-Assisted, Signal-To-Noise Ratio, Stroke, Tomography, X-Ray Computed.
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Does iterative Reconstruction lead to Increased Subjective and Objective Image Quality in Cranial CT in Patients With Stroke? Context: The purpose of this study was to determine whether iterative reconstruction improves the quality of cranial CT (CCT) images of stroke patients. Fifty-one CCT studies of patients with infarction performed with either a low (260 mAs; n = 21) or standard (340 mAs; n = 30) dose were reconstructed with both filtered back projection (FBP) and sinogram-affirmed iterative reconstruction (SAFIRE) with five strength levels (S1-S5). The resulting six image sets (one FBP and one each for SAFIRE levels S1-S5) were rated separately by two blinded radiologists in terms of conspicuity of infarcted areas on a 5-point scale. Noise and infarct-to-normal brain as well as medullary-to-cortical contrast-to-noise ratios (CNRs) were measured. Ratings, noise, and CNRs were intraindividually compared within the same dose group (Fisher exact test) and interindividually between the different dose groups (Wilcoxon-Mann-Whitney U test). The strength level S4 showed the best conspicuity of infarcted areas. Compared with FBP, SAFIRE S4 statistically significantly (p < 0.01) reduced noise and improved CNRs without statistically significant differences in all subjective and objective criteria (p > 0.01) when the dose was reduced. Patients examined with a 260-mAs low-dose were exposed to a statistically significantly lower dose (1.77 vs 2.33 mSv; p < 0.01).
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Iterative reconstruction (SAFIRE at strength level S4) leads to increased subjective and objective image quality in CCT and allows dose reduction (-24%) without losses in the demarcation of ischemic lesions. Final Decision: yes