system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Autoantibodies, Axons, Electromyography, Female, G(M1) Ganglioside, Guillain-Barre Syndrome, Humans, Immunoglobulin G, Male, Middle Aged, Muscle, Skeletal, Neuromuscular Junction, Synaptic Transmission, Young Adult.
user
Is neuromuscular transmission impaired in axonal Guillain -- Barré syndrome? Context: Previous studies have shown that anti-GQ1b antibodies induce massive neuromuscular blocking. If anti-GM1 and -GD1a antibodies have similar effects on the neuromuscular junction (NMJ) in human limb muscles, this may explain selective motor involvement in axonal Guillain--Barré syndrome (GBS). Axonal-stimulating single-fibre electromyography was performed in the extensor digitorum communis muscle of 23 patients with GBS, including 13 with the axonal form whose sera had a high titre of serum IgG anti-GM1 or -GD1a antibodies. All patients with axonal or demyelinating GBS showed normal or near-normal jitter, and no blocking.
assistant
In both axonal and demyelinating GBS, neuromuscular transmission is not impaired. Our results failed to support the hypothesis that anti-GM1 or -GD1a antibody affects the NMJ. In GBS, impulse transmission is presumably impaired in the motor nerve terminal axons proximal to the NMJ. Final Decision: no