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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Antifungal Agents, Candida, Candida albicans, Candida glabrata, Chlorhexidine, Delayed-Action Preparations, Dental Materials, Denture Liners, Diffusion, Drug Carriers, Fluconazole, Humans, Materials Testing, Methacrylates, Methylmethacrylates, Microbial Sensitivity Tests, Polymerization, Temperature, Time Factors, Water.
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Are fungicidal amounts of antifungals released from impregnated denture lining material for up to 28 days? Context: The aim of this study was to investigate the efficacy of a polymeric delivery system impregnated with chlorhexidine or fluconazole against Candida species. Self-cure poly-ethyl methacrylate and tetrahydro-furfuryl methacrylate (PEM/THFM) discs impregnated with pure fluconazole substance (FLUp), fluconazole powder from capsules (FLUc) or chlorhexidine powder (CHX) were incubated in water for up to 28 days at 37 °C. The water was replaced at 24h and 3, 7, 14, 21, 28 days. The amount of released drugs and antifungal activity of the leachates was measured by bioassay. The minimal inhibitory concentration (MIC) of each drug for 46 Candida isolates was determined and compared to the released concentrations. A total of 53.0% of CHX, 38.5% of FLUc and 13.2% of FLUp impregnated into the discs was leached during the 28-day incubation. Of the total amount leached, 71.8% of CHX, 75.1% of FLUc and 70.5% of FLUp was released during the first week of incubation. Antifungal activity was confirmed for up to 28 days.
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Both chlorhexidine and fluconazole become readily leached from PEM/THFM polymer up to four weeks and that the polymerisation of the acrylic does not affect the antimicrobial activity of the agents. Importantly, the amount of drugs released exceeded the MICs of most isolates also during the fourth week of incubation. Final Decision: yes