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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Allografts, Animals, Biomarkers, Biopsy, Needle, Blotting, Western, Caffeic Acids, Chemokine CCL22, Disease Models, Animal, Graft Rejection, Graft Survival, Heart Transplantation, Immunohistochemistry, Immunosuppressive Agents, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Random Allocation, Sensitivity and Specificity, Sirolimus, Tissue Donors, Transplant Recipients, Transplantation Immunology, Treatment Outcome.
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Does tanshinol suppress cardiac allograft rejection in a murine model? Context: Achieving long-term cardiac allograft survival without continuous immunosuppression is highly desired in organ transplantation. Studies have shown that Salvia miltiorrhiza, an herb also known as danshen, improves microcirculation and is highly effective in treating coronary heart disease. Our objective is to determine whether tanshinol, an ingredient of danshen, improves cardiac allograft survival. Fully vascularized heterotopic heart transplantation was performed using BALB/c mice as donors and C57BL/6 mice as recipients, which were then treated with tanshinol and rapamycin. CD4 We found that tanshinol significantly delayed cardiac allograft rejection. It promoted long-term allograft survival induced by rapamycin, a mammalian target-of-rapamycin (mTOR) inhibitor. Tanshinol increased CD4
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Tanshinol suppresses cardiac allograft rejection by recruiting CD4 Final Decision: yes