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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Austria, Biomarkers, Carotid Artery Diseases, Carotid Artery, Common, Chemokine CXCL12, Chromosomes, Human, Pair 10, Coronary Artery Disease, Endothelial Cells, England, Female, Finland, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Odds Ratio, Phenotype, Polymorphism, Single Nucleotide, Regression Analysis, Risk Assessment, Risk Factors, Stem Cells, Tunica Intima, Tunica Media, Ultrasonography, Young Adult.
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Is coronary artery disease-related genetic variant on chromosome 10q11 associated with carotid intima-media thickness and atherosclerosis? Context: To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1α (SDF-1α) plasma levels. Variation on chromosome 10q11.21 has been consistently associated with coronary artery disease. The genetic variant lies upstream of the gene encoding SDF-1α. We genotyped 3 population cohorts (Bruneck [age range, 45 to 94 years; 50.0% men; n=738], Health2000 [age range, 46 to 76 years; 55.4% men; n=1237], and essential hypertension in families collected in the region of Oxford [HTO] [age range, 19 to 88 years; 47.9% men; n=770]) for single-nucleotide polymorphism rs501120 at the 10q11.21 locus and conducted a meta-analysis in these cohorts to ascertain a relationship between the polymorphism and carotid IMT. The analysis showed that individuals with the T/T genotype had a significantly higher carotid IMT than individuals with the C/T or C/C genotype (pooled weighted mean difference, 23 μm [95% CI, 9 to 37 μm], P=0.0014 under a fixed-effects model; and 23 μm [95% CI, 6 to 41 μm], P=0.009 under a random-effects model). In the Bruneck cohort, in which data for carotid atherosclerosis and plasma SDF-1α levels were available, we observed an association of the T/T genotype with a higher burden of atherosclerosis and increased susceptibility to the development of atherosclerosis during a 5-year follow-up (multivariable odds ratio, 1.73 [95% CI, 1.18 to 2.52]; P=0.005 for the recessive model) and an association between the T/T genotype and lower SDF-1α levels (2.62 ng/mL for T/T versus 2.74 ng/mL for C/C or C/T; P=0.023).
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The coronary heart disease-related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis. Final Decision: yes