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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
All are the true regarding hyperophic obstructive cardiomyopathy, except-
assistant
The correct answer is  Ref:Harrison's 19th E pg 1569 It is diastolic dysfunction. At the level of the sarcomere, hyperophic cardiomyopathy mutations lead to enhanced calcium sensitivity, maximal force generation, and ATPase activity. Calcium handling is affected through modification of regulatory proteins. Sarcomere mutations lead to abnormal energetics and impaired relaxation, both directly and as a result of hyperophy.