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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adenosine Diphosphate, Adrenergic beta-Antagonists, Aged, Angioplasty, Blood Platelets, Case-Control Studies, Cohort Studies, Coronary Artery Disease, Female, Flow Cytometry, Humans, Linear Models, Male, Middle Aged, Monocytes, Multivariate Analysis, Neutrophils, Platelet Aggregation, Platelet Aggregation Inhibitors, Prospective Studies, Stents.
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Are β-blockers associated with decreased leucocyte-platelet aggregate formation and lower residual platelet reactivity to adenosine diphosphate after angioplasty and stenting? Context: The beneficial effects of β-blockers on the long-term prognosis of patients with cardiovascular disease may in part be attributable to decreased platelet activation. In this prospective cohort study, we sought to investigate the impact of concomitant β-blocker therapy on sensitive markers of platelet activation and aggregation. Monocyte-platelet (MPA) and neutrophil-platelet aggregate (NPA) formation in vivo and in response to the platelet agonist adenosine diphosphate (ADP) were determined by flow cytometry in 258 patients undergoing angioplasty and stenting. On-treatment residual platelet reactivity to ADP was assessed by multiple electrode aggregometry (MEA). One hundred seventy-five patients of the study population (67·8%) received β-blockers. Treatment with β-blockers was associated with significantly lower MPA and NPA formation in vivo and in response to ADP compared to patients without β-blockers (all P ≤ 0·01). The inverse associations of MPA and NPA formation with β-blocker therapy remained statistically significant after adjustment for differences in patient characteristics by multivariate linear regression analyses (all P < 0·05). Moreover, high levels of MPA in response to ADP as well as high levels of NPAin vivo and in response to ADP were significantly less frequent in patients with β-blocker treatment (all P < 0·05). Finally, on-treatment residual platelet reactivity to ADP by MEA was significantly lower in patients receiving β-blockers (P = 0·005).
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β-Blockers are associated with decreased leucocyte-platelet aggregate formation and lower on-treatment residual platelet reactivity to ADP in patients with dual antiplatelet therapy following angioplasty and stenting. Final Decision: yes