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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNLABELLED. Meshes: Adenoma, Liver Cell, Animals, Carcinoma, Hepatocellular, Cell Cycle, Cell Differentiation, Cell Division, Embryonic Development, Female, Hepatocytes, Liver, Liver Neoplasms, Liver Regeneration, Male, Mice, Mice, Knockout, Mutation, Pregnancy, Transcription Factors.
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Is maid ( GCIP ) involved in cell cycle control of hepatocytes? Context: The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice-in contrast to wild-type controls--develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally.
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These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors. Final Decision: yes