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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Cohort Studies, Depression, Postpartum, Depressive Disorder, Major, Female, Genetic Predisposition to Disease, Humans, Odds Ratio, Polymorphism, Genetic, Predictive Value of Tests, Pregnancy, Risk Factors, Serotonin Plasma Membrane Transport Proteins, Severity of Illness Index.
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Does a serotonin transporter gene polymorphism predict peripartum depressive symptoms in an at-risk psychiatric cohort? Context: Peripartum major depressive disorder (MDD) is a prevalent psychiatric disorder with potential detrimental consequences for both mother and child. Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population. Two hundred and seventy four women with a prior history of MDD were genotyped for 5-HTTLPR and serially evaluated in late pregnancy (gestational weeks 31-40), early post-partum (week 1-8) and late post-partum (week 9-24) for diagnosis of a current major depressive episode (MDE) and depressive symptom severity. 5-HTTLPR S-allele carrier status predicted the occurrence of a MDE in the early post-partum period only (OR=5.13, p=0.017). This association persisted despite continued antidepressant treatment.
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The 5-HTTLPR genotype may be a clinically relevant predictor of early post-partum depression in an at-risk population. Final Decision: yes