system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
The major source of ammonia in kidney
assistant
The correct answer is  Glutamic acid acts as a link between amino acids and ammonia.Ammonia, which is highly toxic, arises in humans primarily from the a-amino nitrogen of amino acids. Tissues, therefore, conve ammonia to the amide nitrogen of the nontoxic amino acid glutamine. Subsequently, in kidney cells, ammonia generated on purpose from glutamine with the help of Glutaminase.Ref: Harper&;s biochemistry; 30th edition; Chapter 28 Catabolism of Proteins & of Amino Acid Nitrogen