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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adipogenesis, Adiponectin, Adipose Tissue, Brown, Animals, Body Weight, Diet, High-Fat, Energy Metabolism, Exenatide, Fasting, Fatty Acids, Feeding Behavior, Gene Expression Regulation, Glucose, Leptin, Lipid Metabolism, Mice, Inbred C57BL, Motor Activity, Obesity, Peptides, Thermogenesis, Triglycerides, Venoms.
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Does exendin-4 improve thermogenic capacity by regulating fat metabolism on brown adipose tissue in mice with diet-induced obesity? Context: This study aimed to investigate the benefits of exendin-4 treatment on brown adipose tissue (BAT) in C57BL/6J mice with high-fat diet (HFD)-induced obesity. We examined the effects of exendin-4 on body adiposity and the level of genes associated with adipogenesis, glucose/lipid uptake, lipolysis, and thermogenesis in mice with diet-induced obesity. Exendin-4 treatment deceased body weight, serum-free fatty acid, and triglyceride levels in HFD-induced obese C57BL/6J mice. Exendin-4 treatment increased the expression of genes associated with adipogenesis, glucose/lipid uptake, lipolysis, and thermogenesis in BAT. Compared with HFD-fed mice, exendin-4 treatment also exhibited elevated energy expenditure and reduced respiratory quotient, but showed similar food intake and locomotor activity.
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Exendin-4 treatment reduced high-fat-induced obesity by decreasing adiposity and increasing thermogenesis. This result suggests that GLP-1 agonist may be a new approach to combat obesity by shifting the energy balance from obesogenesis to thermogenesis. Final Decision: yes