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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which of the following occurs in chronic granulomatous disease?
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The correct answer is  Ans: b (Defective H2O2 production) Ref: Ananthanarayan, 7th ed, p. 157; Harrison, 16th ed, p. 354Chronic granulomatous disease is a disorder of microbial killing characterized by decreased ability of neutrophils to produce H2O2 Patients become succeptible to catalase producing organisms which destroy the small amount of H2O2 in these cells leading to bacterial killing.Granulomas are produced as a 2nd line of defence against organisms, that normally would be removed by acute inflammatory response.Enzyme defect - N ADPH oxidaseScreening test - NBT test (nitroblue tetrazolium dye not reduced by neutrophils in vitro)