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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Biopsy, Glomerulosclerosis, Focal Segmental, Graft Survival, Humans, Kidney Transplantation, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Proportional Hazards Models, Tissue and Organ Procurement, Transplantation, Homologous.
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Does the presence of glomerular sclerosis at time zero have a significant impact on function after cadaveric renal transplantation? Context: The aim was to determine the impact of donor glomerulosclerosis on allograft outcome. The percentage of glomerular sclerosis (%GS) was calculated in protocol biopsies taken at engraftment. Clinical variables were obtained from the Welsh Transplantation Research Group (WTRG) database. Of 210 allografts, 129 showed %GS=0, but 81 kidneys showed %GS between 1 and 60. Patients with %GS=0 had the highest glomerular filtration rate (GFR) at 1 year (62.0 mL/min) and the slowest deterioration of function (-3.8 mL/min per year). Patients with %GS greater than 20 had the lowest GFR at 1 year (36.0 mL/min) and the steepest rate of deterioration (-9.0 mL/min per year). The %GS of 10 alone can reduce GFR at 4 years by 8 mL/min, a similar reduction to a single rejection episode or an increase in donor age of 30 years. Actuarial 5-year graft survival for %GS=0 was 80%, and for %GS greater than 20 was 35% ( P=0.04).
assistant
The findings indicate that a biopsy taken at procurement will provide information for the most appropriate allocation of a kidney. Final Decision: yes