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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adenocarcinoma, Aged, Biomarkers, Tumor, Biopsy, Diagnosis, Differential, Humans, Logistic Models, Male, Predictive Value of Tests, Prostate, Prostate-Specific Antigen, Prostatic Hyperplasia, Prostatic Neoplasms, Risk Factors, Ultrasonography.
user
Is serum PSA adjusted for volume of transition zone ( PSAT ) more accurate than PSA adjusted for total gland volume ( PSAD ) in detecting adenocarcinoma of the prostate? Context: This study evaluates the accuracy of comparing serum prostate-specific (PSA) levels in the range between 4.1 ng/mL and 10.0 ng/mL (monoclonal) to the volume of the transition zone (TZ) of the prostate and total gland volume as a predictor of a positive biopsy. Using sonographic voluming of the entire prostate and of the TZ, prostate-specific antigen density (PSAD) and prostate-specific antigen density of the TZ (PSAT) were calculated in 21 biopsy-positive patients and 38 biopsy-negative patients. Biopsy was directed at sonographically suspicious areas and did not include sextant biopsies. A statistically significant association was determined between a positive biopsy and gland volume, TZ volume, and PSAT. The association of a positive biopsy with PSA and PSAD was not statistically significant.
assistant
PSAT is more accurate in predicting a positive biopsy than is PSAD for PSA levels between 4.1 ng/mL and 10.0 ng/mL. Final Decision: yes