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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Apoptosis, Biomarkers, Tumor, Cell Adhesion, Cell Movement, Cell Proliferation, Colorectal Neoplasms, Epithelial-Mesenchymal Transition, Female, Follow-Up Studies, Gene Expression Profiling, Humans, Immunoenzyme Techniques, Laser Capture Microdissection, Liver Neoplasms, Lymphatic Metastasis, Male, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, Peritoneal Neoplasms, RNA, Messenger, RNA, Small Interfering, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Stromal Cells, Tenascin, Tumor Cells, Cultured.
user
Does tumor-derived tenascin-C promote the epithelial-mesenchymal transition in colorectal cancer cells? Context: Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorectal cancer (CRC) cases. TNC expression in 170 cases of CRC was analyzed by quantitative real-time polymerase chain reaction (PCR). In addition, gene expression arrays using purely-separated cancer tissues of another 86 cases was performed and the functional implications of cancer-specific TNC were investigated. The expression of TNC mRNA was significantly higher in CRC tissues than in the corresponding normal tissues. Cancer cell-specific TNC expression was a significant prognostic factor in CRC cases. Moreover, cancer cell-derived TNC was associated with the epithelial-mesenchymal transition (EMT) signature.
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Cancer cell-derived TNC promotes cancer invasiveness via EMT regulation, and not cancer tissue TNC but cancer cell-specific TNC is a novel indicator of poor prognosis. Final Decision: yes