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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Anti-HIV Agents, Biomimetics, CD4 Antigens, Disease Transmission, Infectious, Female, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Leukocytes, Mononuclear, Mucous Membrane, Vagina, Virion.
user
Does m48U1 CD4 mimetic have a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding? Context: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding.
assistant
M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission. Final Decision: yes