system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Which of the following sulfonylureas cannot be used in patients with kidney failure?
assistant
The correct answer is  Glyburide should not be used in patients with liver disease and CKD due to risk of hypoglycaemia. Glipizide, Gliclazide and Glimepiride are metabolised by liver and hence can be used in patients with CKD.