system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 5-year-old boy is brought to the physician’s office with complaints of being tired constantly, which has limited his ability to walk or play with his friends. Physical examination in the physician’s office is normal. Further testing reveals that the patient has a genetic mutation in an enzyme and muscle biopsy shows high levels of alpha-ketoglutarate and low levels of succinyl-CoA as compared to normal. The enzyme that is most likely deficient in this patient requires which of the following as a cofactor?
assistant
Vitamin B1