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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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A group of investigators is studying the effects of aberrant protein isoforms on the pathogenesis of lung cancer. They observe that three protein isoforms are transcribed from the same 30,160 base-pair-long DNA segment on chromosome 13q. The canonical protein has a primary peptide sequence of 1186 amino acids. The second isoform has 419 amino acids and 100% amino acid sequence homology with the canonical protein. The third isoform has 232 amino acids and 92% amino acid sequence homology with the canonical protein. Which of the following is most likely responsible for the observed phenomenon?
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Alternative pre-mRNA splicing