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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNLABELLED, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Antigens, Neoplasm, Biomarkers, Tumor, CA-125 Antigen, Carcinoembryonic Antigen, Carcinoma, Non-Small-Cell Lung, Female, Humans, Keratin-19, Keratins, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, Serpins.
user
Do positive reactions for both Cyfra21-1 and CA125 indicate worst prognosis in non-small cell lung cancer? Context: We examined four tumour markers [carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), cancer antigen 125 (CA125) and cytokeratin 19 fragment (Cyfra21-1)] in 584 non-small cell lung cancer (NSCLC) patients. After confirmation of a significant correlation between their serum levels and clinical stages, multivariate analysis showed that Cyfra21-1 and CA125 pointed to a negative prognosis; the respective hazard ratios were 2.585 (p = 0.0008) and 2.139 (p = 0.0020) in 121 inoperable adenocarcinoma patients and 2.329 (p = 0.0004) and 1.61 (p = 0.00370) in 205 inoperable NSCLC patients. Also, patients giving positive reactions for both Cyfra21-1 and CA125 had the worst prognoses, with hazard ratios of 6.546 (p < 0.0001) in inoperable adenocarcinoma patients and 4.275 (p < 0.0001) in inoperable NSCLC patients.
assistant
Cyfra21-1 or CA125 tend to imply a negative prognosis. Cyfra21-1 and CA125 together imply the worst prognosis. Final Decision: yes