system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE. Meshes: ADAM Proteins, ADAMTS Proteins, Adult, Epistasis, Genetic, Female, Genotype, Humans, Polymorphism, Single Nucleotide, Primary Ovarian Insufficiency, Receptor, IGF Type 2.
user
Does epistasis between IGF2R and ADAMTS19 polymorphisms associate with premature ovarian failure? Context: Do single nucleotide polymorphisms (SNPs) or synergistic interactions between SNPs and diplotypes within the insulin-like growth factor 2 receptor (IGF2R) and ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ADAMTS19), contribute to premature ovarian failure (POF)?
assistant
Synergistic interactions were detected between SNPs, including a non-synonymous SNP, and diplotypes within IGF2R and ADAMTS19 which may contribute to POF; however, there was no correlation with POF in a single SNP model after Bonferroni correction. Final Decision: yes