system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Which is true about gallstones
assistant
The correct answer is  Recently bacterial infection has been shown to play the role in pathogenesis of gallstone, this adds to the growing pool of studies finding an infectious nidus in these gallstones Brown stones are related to bile statsis and infection Gram negative bacteria (E.coli and Klebsiella) secretes beta-glucuronidase, which deconjugate soluble conjugated bilirubin Free unconjugated bilirubin precipitates and combines with calcium and bile to form brown pigment stones. Stones from whenever static foreign bodies are present in the bole duct (stents or parasites such as clonorchis sinensis and Ascaris lumbricoides Ref: Sabiston 20th edition Pgno : 1492