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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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What is the drug of choice for CM (cytomegalovirus) retinitis in patients with AIDS
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The correct answer is  Ganciclovir is an analogue of acyclovir which is active against all herpes viruses including H.simplex,H.zoster,EBV, & CMV against which it is most active.It is activated intracellularly by virus spcific thymidine kinase& its triphosphate nucleotide preferentially inhibits viral DNA polymerase .This active metabolite attains much higher concentration inside CMV infected cells. I.V infusion of ganciclovir can prevent blindness in AIDS patients with CMV retinitis . Tripathi essentials of medical pharmacology 7th edition pg no 801.