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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Abortion, Spontaneous, Embryo Implantation, Embryo Transfer, Estradiol, Female, Humans, Infertility, Karyotyping, Male, Mosaicism, Ovulation Induction, Pregnancy, Pregnancy Outcome, Sex Chromosome Aberrations, Sperm Injections, Intracytoplasmic, Treatment Outcome.
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Does low-level sex chromosome mosaicism in female partners of couples undergoing ICSI therapy significantly affect treatment outcome? Context: There is an increased rate of chromosomal anomalies, in particular low-level sex chromosome mosaicism, in the female partners of couples undergoing intracytoplasmic sperm injection (ICSI). Among 811 consecutive couples presenting for pre-ICSI chromosome analysis, chromosomal abnormalities were detected in 54 individuals, of which 26 were low-level sex chromosome mosaicism in the females. Attention was focused on the treatment course and outcome of ICSI in 20 couples with low-level sex chromosome mosaicism in the females actually embarking on ICSI treatment (group I, n = 38 ICSI treatment cycles). Applying a case-control design, each of the 20 couples was matched according to female age and source of spermatozoa to couples without a chromosomal abnormality in either of the partners (group II, n = 38 ICSI treatment cycles). No significant differences were found between the groups in ovarian response, fertilization rate and number of embryos transferred. Pregnancy rates, as well as implantation and abortion rates did not differ significantly between the groups.
assistant
The data suggest that low-level sex chromosome mosaicism in females has no major effect on the course and outcome of ICSI. Final Decision: no