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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Activities of Daily Living, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Ulcer Agents, Asthma, Circadian Rhythm, Cross-Over Studies, Double-Blind Method, Emotions, Female, Forced Expiratory Volume, Gastroesophageal Reflux, Health Status, Humans, Male, Middle Aged, Omeprazole, Peak Expiratory Flow Rate, Placebos, Quality of Life, Reproducibility of Results, Treatment Outcome.
user
Does omeprazole improve peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux? Context: The aim of this study was to determine if omeprazole improves pulmonary function and quality of life in asthmatics with gastroesophageal reflux. This was a double blind, randomized, placebo-controlled cross-over trial. After a 4-wk lead-in period, nine patients with documented asthma and gastroesophageal reflux, were prescribed either omeprazole 20 mg, daily or placebo for 8 wk and then crossed over to the alternate treatment. Outcome measurements included: forced expiratory volume at 1 s (FEV1), peak expiratory flow rate (PEFR), and responses on the Asthma Quality of Life Questionnaire, a validated disease specific measure of functional status. After omeprazole treatment, compared with placebo, patients had higher mean morning and evening PEFR, mean absolute difference (95% CI): morning: 37.8 L/min. (10.9-64.6), evening: 31.2 (3.2-59.2). Omeprazole treatment led to higher mean overall scores on the Asthma Quality of Life Questionnaire, and on the subdomains of activity limitation, symptoms, and emotions (p = 0.039, 0.049, 0.024, 0.040). A trend toward higher FEV1 (mean: 15.6% difference) with omeprazole failed to reach statistical significance (p > 0.2).
assistant
After taking omeprazole for 8 wk, asthmatics with GER have better PEFR and quality of life than after placebo. Final Decision: yes