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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Cation Transport Proteins, Chemokine CCL17, Cytokines, Dermatitis, Atopic, Epidermis, Female, Guanidines, Hydrogen-Ion Concentration, Immunoglobulin E, Mice, Inbred C57BL, Serine Proteases, Sodium-Hydrogen Exchanger 1, Sodium-Hydrogen Exchangers.
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Is defective maintenance of pH of stratum corneum correlated with preferential emergence and exacerbation of atopic-dermatitis-like dermatitis in flaky-tail mice? Context: Neutralization of stratum corneum (SC) pH, which is induced by a variety of stimuli, such as scratching, use of soap and inflammation, can stimulate activity of serine protease (SPase). Activation of SPase induces production of thymic stromal lymphopoietin (TSLP) through protease-activated receptor-2. Both reduced expression of natural moisturizing factors, which are required for maintenance of SC pH, and the preferential development of atopic dermatitis (AD)-like dermatitis are found in flaky-tail mice (FTM) with a loss-of-function mutation in filaggrin. We examined possible correlations between disturbance of responses to an exogenous stimulus of SC neutralization and the preferential emergence of AD-like dermatitis in FTM. FTM and wild-type mice (C57BL/6) were subjected to an SC-neutralization stimulus via application of 1,1,3,3-tetramethylguanidine (TMG). TMG was applied to young mice at a time when FTM had not yet developed significant dermatitis, and we examined their ability to maintain SC acidity and several parameters associated with AD-like dermatitis. The recovery of SC pH after the application of TMG was delayed in FTM, presumably because of unchanged expression of Na(+)/H(+) antiporter 1, which is involved in maintenance of SC acidity. Cutaneous inflammation with elevated SPase activity and serum levels of TSLP, thymus and activation-regulated chemokine and IgE were induced only in TMG-treated FTM.
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Our results suggest that defective maintenance of pH of SC is correlated with emergence and exacerbation of AD-like dermatitis in FTM. Final Decision: yes