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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: African Continental Ancestry Group, Age Distribution, Aged, Aorta, Thoracic, Arteriosclerosis, C-Reactive Protein, Chlamydophila Infections, Chlamydophila pneumoniae, Cohort Studies, Comorbidity, Cross-Sectional Studies, Echocardiography, Transesophageal, European Continental Ancestry Group, Female, Hispanic Americans, Humans, Leukocyte Count, Linear Models, Male, New York City, Odds Ratio, Risk Factors, Serologic Tests, Severity of Illness Index, Sex Distribution, Stroke.
user
Is leukocyte count associated with aortic arch plaque thickness? Context: Leukocyte count has been associated with cardiovascular and cerebrovascular disease, including carotid plaque thickness, in several studies. We hypothesized that white blood cell count is associated with aortic arch plaque thickness (AAPT). Leukocyte count was measured in randomly selected stroke-free community participants undergoing transesophageal echocardiography. AAPT was measured for each subject and dichotomized into <4 and > or =4 mm (thick plaque). Multivariate linear and logistic regression was used to calculate the effect of leukocyte count on AAPT after adjustment for potential confounding factors. Mean age of the 145 participants was 68.5+/-8.3 years; 43.5% were women; 15.9% were white; 31.7% were black; and 49.0% were Hispanic. Mean leukocyte count was 5.88+/-1.76x10(9)/L. Each unit increase in leukocyte count was associated with a mean 0.28-mm increase in AAPT (P=0.0036). After adjustment for other atherosclerosis risk factors, including age, sex, hypertension, diabetes, hyperlipidemia, and smoking, the relationship persisted (mean increase in AAPT, 0.24 mm; P=0.0064). Thirty-five participants (24.1%) had AAPT > or =4 mm. Mean leukocyte count among those with thick plaque was significantly higher than among those with plaque <4 mm (6.54+/-1.60 versus 5.65+/-1.76x10(9)/L, respectively; P=0.009). Each unit increase in leukocyte count was associated with an increased risk of thick plaque (adjusted odds ratio, 1.38; 95% CI, 1.05 to 1.79). The relationships were similar for men and women and for those <70 or > or =70 years of age.
assistant
Leukocyte count is associated with AAPT and is specifically correlated with AAPT > or =4 mm, a degree of thickening associated with increased stroke risk. These findings are consistent with current hypotheses regarding the inflammatory or infectious etiology of risk of atherosclerosis and stroke. Final Decision: yes