system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 60-year-old man comes to the physician because of progressive pain in his right hip and lower back over the past 4 weeks. He describes the pain as dull and constant. It is worse with exertion and at night. Over the past 2 months, he has helped his son with renovating his home, which required heavy lifting and kneeling. His father died of prostate cancer. He drinks 2–3 beers daily. Vital signs are within normal limits. Examination shows localized tenderness over the right hip and groin area; range of motion is decreased. Hearing is mildly decreased on the right side. The remainder of the examination shows no abnormalities. Laboratory studies show:
Hemoglobin 15 g/dL
Serum
Total protein 6.5 g/dL
Bilirubin 0.8 mg/dL
Alanine aminotransferase 20 U/L
Alkaline phosphatase (ALP) 950 U/L
γ-Glutamyltransferase (GGT) 40 U/L (N=5–50)
Calcium 9 mg/dL
Phosphate 4 mg/dL
Parathyroid hormone
450 pg/mL
An x-ray of the hip shows cortical thickening and prominent trabecular markings. Which of the following is the most likely underlying mechanism of this patient's symptoms?"
assistant
Increased rate of bone remodeling