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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Case-Control Studies, DNA-Cytosine Methylases, Female, Gene Frequency, Glutathione S-Transferase pi, Heterozygote, Humans, Male, Middle Aged, Parkinson Disease, Secondary, Pesticides, Polymerase Chain Reaction, Polymorphism, Genetic, Risk Factors, Sex Factors, Site-Specific DNA-Methyltransferase (Adenine-Specific).
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Are exposure to pesticides and heterozygote genotype of GSTP1-Alw26I associated to Parkinson 's disease? Context: This study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD). A study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP). Patients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients.
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Exposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings. Final Decision: yes