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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Congenital Abnormalities, Ear, Middle, Female, Fertilization in Vitro, Genes, Dominant, Hearing Disorders, Humans, Infant, Newborn, Male, Pregnancy, Pregnancy Outcome, Surrogate Mothers, Uterus, Vagina.
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Is congenital absence of the uterus and vagina commonly transmitted as a dominant genetic trait : outcomes of surrogate pregnancies? Context: To determine the inheritance pattern of congenital absence of the uterus and vagina in affected women undergoing surrogacy IVF with this disorder. Retrospective study. A hospital-based reproductive endocrinology and infertility center. Women diagnosed with congenital absence of the uterus and vagina undergoing IVF with subsequent transfer of embryos to a surrogate uterus. Questionnaires were sent to all infertility treatment centers performing surrogate procedures. Number, gender, and frequency of congenital anomalies in progeny. Thirty-two of 53 surveyed programs responded (60%). One hundred sixty-two IVF cycles were performed, and 34 liveborn children were delivered (half female). No congenital anomalies were found, except for one male child with a middle ear defect and hearing loss.
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These results strongly suggest that congenital absence of the uterus and vagina, if genetically transmitted, is not inherited commonly in a dominant fashion. Final Decision: no