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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Type 1 Dentinogenesis imperfecta is caused by mutation in:
assistant
The correct answer is  Type 1 Dentinogenesis imperfecta is caused by a mutation in the DSPP gene (gene map locus 4q21.3), encoding dentin phosphoprotein and dentin sialoprotein. While Type 2 is caused by DMP-1, BSP-1, SPP1 gene.
Ref: Shafer's textbook of oral pathology 7th edition page55