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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Antioxidants, Aryldialkylphosphatase, Basketball, Blood Pressure, Carboxylic Ester Hydrolases, Catecholamines, Creatine Kinase, Dietary Supplements, Exercise, Heart Rate, Humans, L-Lactate Dehydrogenase, Lactic Acid, Lipid Peroxidation, Lipids, Male, Muscle Proteins, Oxidative Stress, Pyruvic Acid, Young Adult, alpha-Tocopherol.
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Does alpha-tocopherol supplementation prevent the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals? Context: To investigate PON 1/Aryl activities in basketball players with or without alpha-T supplementation pre- and post-training. Vitamin E (alpha-tocopherol, alpha-T) reduces lipid peroxidation. Paraoxonase 1/arylesterase (PON 1/Aryl) activities are closely related to oxidation and atherogenesis. Blood was obtained from 10 players pre- (group A), post-exercise (group B) and after 1 month on alpha-T (200 mg per 24 h orally) supplementation pre- (group C) and post-exercise (group D). Lactate, pyruvate, muscle enzyme activities, creatine kinase, lactate dehydrogenase and total antioxidant status (TAS) were measured with commercial kits. Catecholamines and alpha-T were determined with high-performance liquid chromatography methods and PON 1/Aryl activities spectrophotometrically. Lactate, pyruvate, muscle enzyme activities and catecholamines were increased (P<0.001) in all groups post-training. Alpha-T levels remained unaltered pre- vs post-exercise. TAS was decreased in all the groups post training. PON 1/Aryl activities were significantly decreased post-exercise (group B) (PON1: 65+/-12 U min(-1) ml(-1), Aryl: 58+/-14 KU min(-1) ml(-1)) as compared to those pre-exercise (group A) (PON1: 142+/-16 U min(-1) ml(-1), Aryl: 114+/-12 KU min(-1) ml(-1), P<0.001). In contrast, the studied enzyme activities remained practically unaltered after alpha-T supplementation pre- vs post-training. Both enzyme activities positively correlated to TAS (r=0.60, P<0.001).
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Alpha-T supplementation may result in protection of the enzyme PON 1/Aryl activities from free radical production. Final Decision: yes