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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Alprostadil, Animals, Blood Flow Velocity, Blood Pressure, Carbon Dioxide, Epoprostenol, Hypertonic Solutions, Lung Transplantation, Organ Preservation, Platelet Aggregation Inhibitors, Pulmonary Circulation, Pulmonary Gas Exchange, Swine, Vascular Resistance, Vasodilator Agents.
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Does prostaglandin E1 or prostacyclin in Euro-Collins solution fail to improve lung preservation? Context: In search of the ideal composition of the flush solution for pulmonary preservation, we studied the effects of prostaglandin E1 (PGE1) and prostacyclin as an additive to Euro-Collins solution (ECS) on pulmonary hemodynamics and gas exchange in a porcine single lung transplantation model using extracorporeal circulation and right heart bypass. Twenty-two pigs served as donors. The animals were randomized to receive either modified ECS alone (control group, n = 8), ECS with 100 micrograms/L of PGE1 (PGE1 group, n = 6), or ECS with 200 micrograms/L of prostacyclin (prostacyclin group, n = 8). Left lung transplantation was performed in 22 recipients after approximately 4 hours of cold ischemia. Carbon dioxide elimination was significantly depressed in the two prostaglandin groups, and the use of PGE1 was associated with a significant decrease in arterial oxygen tension compared with the control group. Both drugs were inefficient in alleviating the increase in pulmonary vascular resistance after transplantation.
assistant
The use of prostaglandins as constituents of the flush solution was not followed by any improvement of early graft function after cold ischemia. Final Decision: yes