system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adolescent, Adult, African Continental Ancestry Group, Cyclic GMP, Endothelin-1, European Continental Ancestry Group, Female, Humans, Hypertension, Male, Natriuresis, Nitric Oxide, Sodium, United States.
user
Are urinary excretion of vasoactive factors correlated to sodium excretion? Context: The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans. Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults. Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans.
assistant
The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans. Final Decision: yes