system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 38 year old female patient was on Isoniazid therapy for tuberculosis. She developed rashes on the exposed pas of her body. She has disoriented memory. Family members gives history of diarrhea also. What is the diagnosis:
assistant
The correct answer is  Isoniazid inhibits the endogenous synthesis of niacin. So the patient has developed pellagra i.e. dermatitis, dementia and diarrhea. Prolonged treatment with isoniazid leads to pyridoxine deficiency, which is required for endogenous synthesis of niacin.