system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, RESULTS. Meshes: Adolescent, Antibodies, Bacterial, Antigens, Bacterial, Child, Child, Preschool, England, Female, Healthy Volunteers, Humans, Infant, Male, Meningococcal Infections, Meningococcal Vaccines, Neisseria meningitidis, Serogroup B, Predictive Value of Tests, Serum Bactericidal Antibody Assay, Vaccination, Wales.
user
Does bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirm that MATS underestimates 4CMenB vaccine strain coverage? Context: 4CMenB (Bexsero), a vaccine developed against invasive meningococcal disease caused by capsular group B strains (MenB), was recently licensed for use by the European Medicines Agency. Assessment of 4CMenB strain coverage in specific epidemiologic settings is of primary importance to predict vaccination impact on the burden of disease. The Meningococcal Antigen Typing System (MATS) was developed to predict 4CMenB strain coverage, using serum bactericidal antibody assay with human complement (hSBA) data from a diverse panel of strains not representative of any specific epidemiology. To experimentally validate the accuracy of MATS-based predictions against strains representative of a specific epidemiologic setting. We used a stratified sampling method to identify a representative sample from all MenB disease isolates collected from England and Wales in 2007-2008, tested the strains in the hSBA assay with pooled sera from infant and adolescent vaccinees, and compared these results with MATS. MATS predictions and hSBA results were significantly associated (P=0.022). MATS predicted coverage of 70% (95% CI, 55-85%) was largely confirmed by 88% killing in the hSBA (95% CI, 72-95%). MATS had 78% accuracy and 96% positive predictive value against hSBA.
assistant
MATS is a conservative predictor of strain coverage by the 4CMenB vaccine in infants and adolescents. Final Decision: yes