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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Cerebral Hemorrhage, Female, Fibrinolytic Agents, Follow-Up Studies, Humans, Infusions, Intravenous, Male, Recovery of Function, Retrospective Studies, Stroke, Time Factors, Tissue Plasminogen Activator, Treatment Outcome.
user
Is recanalization within one hour after intravenous tissue plasminogen activator associated with favorable outcome in acute stroke patients? Context: Early recanalization after tissue plasminogen activator (t-PA) infusion greatly improves outcome in stroke patients. However, the time threshold of early recanalization for a favorable outcome remains unclear. The aim of this study was to assess patient outcome 3 months after t-PA therapy among patients with early, delayed and without recanalization. Consecutive patients with major brain artery occlusion on magnetic resonance angiography (MRA) before t-PA infusion were enrolled. We divided the patients into 3 groups according to the findings of follow-up MRA 1 and 24 h after t-PA: the early group who had recanalization within 1 h after t-PA; the delayed group who had recanalization between 1 and 24 h, and the no recanalization group. We then assessed the outcomes (modified Rankin score 0-1) 3 months after t-PA therapy among the 3 groups. A total of 92 patients (53 men, mean age 75.8 +/- 10.3 years) were enrolled. A favorable outcome was most frequently observed in the early group (n = 39, 40.6%), followed by the delayed group (n = 25, 18.2%), and the no recanalization group (n = 28, 10.5%; p = 0.037). After adjusting for age, atrial fibrillation and NIHSS score, the adjusted OR for early recanalization when compared with no recanalization was 7.11 (95% CI 1.177-43.063; p = 0.032) for a favorable outcome, while the adjusted OR for delayed recanalization was 1.75 (95% CI 0.104-29.356; p = 0.698).
assistant
Early recanalization within 1 h after intravenous t-PA is associated with a favorable outcome in stroke patients. Final Decision: yes