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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Acyl-CoA Oxidase, Animals, Carnitine O-Palmitoyltransferase, Fatty Acids, Omega-3, Fish Oils, Gene Expression, Glycerol-3-Phosphate O-Acyltransferase, Ion Channels, Lipid Metabolism, Liver, Male, Mitochondrial Proteins, Myocardium, Organ Specificity, Peroxisome Proliferator-Activated Receptors, Rats, Rats, Wistar, Sulfides, Time Factors, Uncoupling Protein 3.
user
Is long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil associated with increased cardiac content of n-3 fatty acids in rat? Context: Excess peroxisome proliferator-activated receptor (PPAR) stimulation has been associated with detrimental health effects including impaired myocardial function. Recently, supplementation with n-3 polyunsaturated fatty acids (PUFA) has been associated with improved left ventricular function and functional capacity in patients with dilated cardiomyopathy. We investigated the long-term effects of the pan-PPAR agonist tetradecylthioacetic acid (TTA) and/or high-dose fish oil (FO) on cardiac fatty acid (FA) composition and lipid metabolism. Male Wistar rats were given one out of four different 25% (w/v) fat diets: control diet; TTA diet; FO diet; or diet containing both TTA and FO. After 50 weeks n-3 PUFA levels were increased by TTA and FO in the heart, whereas liver levels were reduced following TTA administration. TTA was associated with a decrease in arachidonic acid, increased activities of carnitine palmitoyltransferase II, fatty acyl-CoA oxidase, glycerol-3-phosphate acyltransferase, and fatty acid synthase in the heart. Furthermore, cardiac Ucp3 and Cact mRNA was upregulated.
assistant
Long-term treatment with the pan-PPAR agonist TTA or high-dose FO induced marked changes in PUFA composition and enzymatic activity involved in FA metabolism in the heart, different from liver. Changes included increased FA oxidation and a selective increase in cardiac n-3 PUFA. Final Decision: yes