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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: C-Reactive Protein, Cardiopulmonary Bypass, Cognition Disorders, Coronary Artery Bypass, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Inflammation, Interleukin-2 Receptor alpha Subunit, Interleukin-6, Male, Middle Aged, Postoperative Complications, Preoperative Care, Receptors, Interleukin, Retrospective Studies, Risk Factors, Time Factors, Treatment Failure, Tumor Necrosis Factor-alpha.
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Does preoperative statin therapy reduce cognitive dysfunction after cardiopulmonary bypass? Context: The purpose of this study was to determine if patients receiving statin therapy before coronary artery bypass grafting surgery would have less cognitive dysfunction after cardiopulmonary bypass as a consequence of a diminished inflammatory response. Retrospective observational study of patients undergoing coronary artery bypass grafting surgery. Referral center for cardiothoracic surgery at a university hospital. Four hundred forty patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass. None. Thirty-five percent of patients received statins in the preoperative period. Multivariable analysis revealed no effect of preoperative statin therapy on cognitive function (p = 0.67). Post hoc analysis revealed that statin therapy at hospital discharge was associated with less improvement in cognitive performance at 6 weeks after surgery (p = 0.011). No significant differences were found between statin therapy groups in either range or maximum value of any of the cytokines (p > 0.05).
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Preoperative statin therapy did not decrease the inflammatory response to cardiopulmonary bypass or the cognitive dysfunction commonly seen after cardiac surgery. Final Decision: no