system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNLABELLED, RESULTS. Meshes: Animals, Arginase, Cells, Cultured, Complement Pathway, Alternative, Cytokines, Fasciola hepatica, Fascioliasis, Gene Expression Regulation, Intercellular Signaling Peptides and Proteins, Lectins, Liver, Macrophage Activation, Macrophages, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Differentiation Factor 88, Th1-Th2 Balance, beta-N-Acetylhexosaminidases.
user
Does the absence of MyD88 have no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection? Context: Alternatively activated macrophages (AAMφ) play important roles in allergies and responses toparasitic infections. However, whether signaling through toll-like receptors (TLRs) plays any role in AAMφ induction when young Fasciola hepatica penetrates the liver capsule and migrates through the liver tissue is still unclear. The data show that the lack of myeloid differentiation factor 88 (MyD88) has no effect on the AAMφ derived from the bone marrow (BMMφ) in vitro and does not impair the mRNA expression of arginase-1, resistin-like molecule (RELMα), and Ym1 in BMMφs. The Th2 cytokine production bias in splenocytes was not significantly altered in F. hepatica-infected mice in the absence of MyD88 in vitro and in the pleural cavity lavage in vivo. In addition, MyD88-deficiency has no effect on the arginase production of the F. hepatica elicited macrophages (Fe Mφs), production of RELMα and Ym1 proteins and mRNA expression of Ym1 and RELMα of macrophages in the peritoneal cavity 6 weeks post F. hepatica infection.
assistant
The absence of MyD88 has no effect on presence of AAMφ 6 weeks post F. hepatica infection. Final Decision: yes