system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE. Meshes: Abortion, Habitual, Adult, DNA Methylation, Humans, Infertility, Infertility, Male, Male, Methylenetetrahydrofolate Reductase (NADPH2), Promoter Regions, Genetic, Retrospective Studies, Semen, Semen Analysis.
user
Does methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlate with recurrent spontaneous abortion? Context: Is the methylation status of the methylenetetrahydrofolate reductase (MTHFR) promoter region in semen samples associated with 'recurrent spontaneous abortion' (RSA)?
assistant
MTHFR promoter hypermethylation is more frequent in semen samples from RSA couples than in semen samples from infertile couples with no history of RSA (NRSA) and affects the whole sperm population significantly more often. Final Decision: yes