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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Which among the following is NOT a coenzyme of pyruvate dehydrogenase during the decarboxylation of pyruvate?
assistant
The correct answer is  Pyruvate is oxidatively decarboxylated by pyruvate dehydrogenase (PDH) complex, producing acetyl CoA, which is the major fuel for the tricarboxylic acid cycle. This multienzyme complex requires five coenzymes: Thiamine pyrophosphate Lipoic acid FAD NAD+ Coenzyme A Pyruvate dehydrogenase is inhibited by its products, acetyl-CoA, and NADH Ref: Biochemistry By Richard A. Harvey (Ph. D.), Richard A. Harvey, Denise R. Ferrier, 2011, Page 114.