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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Cell Nucleus, Child, Preschool, Congenital Hyperinsulinism, Female, Humans, Infant, Infant, Newborn, Islets of Langerhans, Male, Microscopy, Electron.
user
Does enhanced Islet Cell Nucleomegaly define Diffuse Congenital Hyperinsulinism in Infancy but Not Other Forms of the Disease? Context: To quantify islet cell nucleomegaly in controls and tissues obtained from patients with congenital hyperinsulinism in infancy (CHI) and to examine the association of nucleomegaly with proliferation. High-content analysis of histologic sections and serial block-face scanning electron microscopy were used to quantify nucleomegaly. Enlarged islet cell nuclear areas were 4.3-fold larger than unaffected nuclei, and the mean nuclear volume increased to approximately threefold. Nucleomegaly was a normal feature of pediatric islets and detected in the normal regions of the pancreas from patients with focal CHI. The incidence of nucleomegaly was highest in diffuse CHI (CHI-D), with more than 45% of islets containing two or more affected cells. While in CHI-D nucleomegaly was negatively correlated with cell proliferation, in all other cases, there was a positive correlation.
assistant
Increased incidence of nucleomegaly is pathognomonic for CHI-D, but these cells are nonproliferative, suggesting a novel role in the pathobiology of this condition. Final Decision: yes