system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Anticipation is seen in -
assistant
The correct answer is  Ans. is 'c' i.e., Trinucleotide-repeat expansion Anticipation o Anticipation is a phenomenon where by the symptoms of a genetic disorders become apparent at an earlier age as it is passed to next generation. In most cases, an increased severity of symptoms is also noted. In triplet nucleotide repeat mutation, the DNA fragment is unstable and tends to expand fuher during cell division. So, in succesive generations the expanded repeat increases and the manifestations of disease may worsen or to be observed at an earlier age; this phenomenon is referred to as anticipation.