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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Hypercalcemia is most commonly associated in which of the following cancers?
assistant
The correct answer is  The most common neoplasm associated with hypercalcemia is squamous cell carcinoma. Other tumors often associated with paraneoplastic hypercalcemia are carcinomas of the lung, kidney, breast and ovary. Paraneoplastic hypercalcemia is caused by parathyroid hormone-related protein (PTHRP) secreted by these tumours. PTHRP increases bone resorp-tion and renal calcium uptake, while inhibiting renal phosphate transpo, effects that raise serum calcium levels.