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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Mutation of which of the following gene is most impoant in paroxysmal nocturnal hemaglobinuria?
assistant
The correct answer is  Ans. is 'c Glycosyl phosphatidylinositol o PNH results from acquired mutation that inhibits the synthesis of Glycosyl-phosphatidyl-inositol (GPI). o The GPI linked proteins that are missing are membrane inhibitors of reactive lysis (MIRL; CD59), delay accelerating factor (DAF; CD55), C8 binding protein, urokinase plasminogen activator receptor, leukocyte alkaline phosphatase (LAP).