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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS. Meshes: Air Pollutants, Animals, Bronchoalveolar Lavage Fluid, Interleukin-13, Mice, Ozone, Toxicity Tests.
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Does iL-33 drive Augmented Responses to Ozone in Obese Mice? Context: Ozone increases IL-33 in the lungs, and obesity augments the pulmonary effects of acute ozone exposure. To assess the role of IL-33 in the augmented effects of ozone observed in obese mice. Lean wildtype and obese 
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Ozone caused greater increases in BAL IL-33, neutrophils, and airway responsiveness in obese than lean mice. Anti-ST2 reduced ozone-induced airway hyperresponsiveness and inflammation in obese mice but had no effect in lean mice. Obesity also augmented ozone-induced increases in BAL CXCL1 and IL-6, and in BAL type 2 cytokines, whereas anti-ST2 treatment reduced these cytokines. In obese mice, ozone increased lung IL-13 Final Decision: yes