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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Amyotrophic Lateral Sclerosis, Asian Continental Ancestry Group, China, Genetic Predisposition to Disease, Genotype, Hemochromatosis Protein, Histocompatibility Antigens Class I, Humans, Membrane Proteins, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide.
user
Is h63D polymorphism in the hemochromatosis gene associated with sporadic amyotrophic lateral sclerosis in China? Context: The H63D polymorphism in the hemochromatosis (HFE) gene has been reported as a risk factor for amyotrophic lateral sclerosis (ALS) in Europe and America, but no data have been reported for Asia. Here, we investigated the possible association between H63D and sporadic ALS (sALS) in a Chinese Han population. A total of 195 individuals with sALS from three centers in China and 405 unrelated healthy controls were recruited. All subjects were genotyped by restriction fragment length polymorphism (RFLP) analysis. Sporadic ALS was significantly related to the H63D polymorphism in heterozygous carriers (odds ratio 3.10, 95%CI: 1.49-6.47, P=0.002).
assistant
The HFE H63D polymorphism may contribute to the development of sALS in Chinese. Final Decision: yes