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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: 9,10-Dimethyl-1,2-benzanthracene, Animals, Carcinogens, Cell Transformation, Neoplastic, Female, Mice, Mice, Knockout, Protein Kinase C-alpha, Skin Neoplasms.
user
Does pKCα suppress 7,12-dimethylbenz [ a ] anthracene-induced skin tumor formation? Context: Protein kinase C (PKC)α is distributed in almost all tissues and participates in various signaling pathways. However, the role of PKCα in carcinogenesis remains unclear. In this study, we performed complete skin carcinogenesis in PKCα knockout mice by repeated administration of 7,12-dimethylbenz[a]anthracene (DMBA). Complete skin carcinogenesis was performed by repeated DMBA treatment using PKCα knockout mice. The number of tumors was determined weekly. Tumor types were determined by Hematoxylin and eosin (H & E) analysis. Tumor growth was assayed by proliferating cell nuclear antigen (PCNA) staining. In the knockout mice, the average number of tumors was 16.6/mouse at 20 weeks. In contrast, in the wild-type (WT) mice, the tumor number was 6.9/mouse. Growth and malignant grade of tumors in PKCα knockout mice did not differ from those in WT mice.
assistant
PKCα suppresses tumor formation, but not tumor growth and progression in skin carcinogenesis. Final Decision: yes