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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Animals, Antioxidants, Aorta, Abdominal, Biomarkers, Constriction, Dantrolene, Disease Models, Animal, Glutathione, Male, Malondialdehyde, Neuroprotective Agents, Oxidative Stress, Rabbits, Reperfusion Injury, Spinal Cord, Spinal Cord Ischemia.
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Can dantrolene protect spinal cord against ischemia/reperfusion injury? Context: The aim of this experimental study was to investigate the possible protective effect of dantrolene on neuronal injury induced by aortic ischemia/reperfusion (I/R). Nineteen rabbits were divided into three groups: sham (group 1, n = 5, no I/R), control (group 2, n = 7, only I/R) and dantrolene (group 3, n = 7, dantrolene + I/R). Abdominal aortic occlusion between the renal arteries and iliac bifurcations was carried out for 30 min. The spinal cord functions of the subjects were assessed using the Tarlov Scale. Blood and cord tissue samples were taken for biochemical and histopathological evaluation. Tarlov scores in group 3 were significantly higher than in group 2 ( P<0.05). In group 3, the MDA levels of the spinal cord decreased significantly compared to those of group 2 ( P<0.05). In rabbits with I/R (group 2), the GSH levels of the spinal cord decreased significantly compared to those of group 1 ( P<0.01), but dantrolene pretreatment significantly prevented a decrease in GSH levels. Histopathological examination showed that group 3 had less vascular proliferation, hemorrhage, edema and neuron loss than group 2.
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It was concluded that dantrolene applied after ischemia might help protect the spinal cord against ischemia/reperfusion injury.