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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Adult, Aged, Blood Cells, Blood Glucose, Body Mass Index, Carnitine, Diabetes Mellitus, Type 2, Female, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Lipid Metabolism, Middle Aged, Overweight, Oxidation-Reduction, Palmitates, Palmitoylcarnitine.
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Does palmitoyl-carnitine production by blood cells associate with the concentration of circulating acyl-carnitines in healthy overweight women? Context: Circulating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans. However, the mechanisms whereby circulating acyl-CNTs are increased in these conditions and their role in whole-body metabolism remains unknown. The purpose of this study was to determine if, in humans, blood cells contribute in production of circulating acyl-CNTs and associate with whole-body fat metabolism. Eight non-diabetic healthy women (age: 47 ± 19 y; BMI: 26 ± 1 kg·m
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In women, blood cells contribute to plasma acyl-CNT levels and the acyl-CNT production is linked to plasma palmitate oxidation, a marker of whole-body fat metabolism. Future studies are needed to confirm the role of blood cells in acyl-CNT and lipid metabolism under different physiological (i.e., in response to meal) and pathological (i.e., hyperlipidemia, IR and T2D) conditions. Final Decision: yes