system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 35-year-old man comes to the physician because of progressive swelling of his legs over the past 2 months. During this period, the patient has had an unintentional 5-kg (11-lb) weight gain. He also reports frequent numbness of the tips of his fingers and cramping in his back and leg muscles. He has a history of HIV infection treated with combined antiretroviral therapy. The patient immigrated to the US from Nigeria 3 years ago. His temperature is 37°C (98.6°F), pulse is 80/min, and blood pressure 150/90 mm Hg. Physical examination shows 3+ periorbital and lower extremity edema bilaterally. Sensation to pinprick and light touch is decreased around the mouth and along the fingers. Laboratory studies show:
Serum
Albumin 2.5 g/dL
Total cholesterol 270 mg/dL
HIV antibody positive
Urine
Blood negative
Protein +4
RBC 1-2/hpf
RBC casts negative
A kidney biopsy is most likely to show which of the following findings under light microscopy?"
assistant
Segmental sclerosis