system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 10-year-old boy with trisomy 21 arrives for his annual check-up with his pediatrician. His parents explain that over the past week, he has been increasingly withdrawn and lethargic. On examination, lymph nodes appear enlarged around the left side of his neck; otherwise, there are no remarkable findings. The pediatrician orders some routine blood work.
These are the results of his complete blood count:
WBC 30.4 K/μL
RBC 1.6 M/μL
Hemoglobin 5.1 g/dL
Hematocrit 15%
MCV 71 fL
MCH 19.5 pg
MCHC 28 g/dL
Platelets 270 K/μL
Differential:
Neutrophils 4%
Lymphocytes 94%
Monocytes 2%
Peripheral smear demonstrates evidence of immature cells and the case is referred to hematopathology. On flow cytometry, the cells are found to be CALLA (CD10) negative. Which of the following diseases is most associated with these clinical and cytological findings?
assistant
Precursor T-cell acute lymphoblastic leukemia/lymphoma