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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Cholesterol, LDL, DNA Methylation, Epigenesis, Genetic, European Continental Ancestry Group, Genetic Association Studies, Genome, Human, Humans, Hyperlipoproteinemia Type II, Hypertension, Intra-Abdominal Fat, Male, Obesity, Morbid, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Quantitative Trait Loci, RNA, Messenger, Receptors, Adrenergic, beta-3, Waist-Hip Ratio.
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Is aDRB3 gene promoter DNA methylation in blood and visceral adipose tissue associated with metabolic disturbances in men? Context: ADRB3 DNA hypermethylation was recently associated with dyslipidemia in familial hypercholesterolemia (FH). In this study, we verified whether ADRB3 DNA methylation in blood and visceral adipose tissue (VAT) was associated with obesity and its related complications. DNA methylation levels were measured in the blood of 61 FH men, and the blood and VAT of 30 severely obese men. Common ADRB3 polymorphisms were genotyped in all subjects. Higher ADRB3 DNA methylation levels were significantly associated with lower low-density lipoprotein cholesterol levels (r = -0.40; p = 0.01) in FH, and with a lower waist-to-hip ratio (r = -0.55; p = 0.01) and higher blood pressure (r = 0.43; p = 0.05) in severely obese men. ADRB3 g.-843C>T and p.W64R polymorphisms were found to be strongly associated (p < 0.001) with ADRB3 DNA methylation and mRNA levels.
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Although further studies are needed, these results suggest that epigenetic changes at the ADRB3 gene locus might be involved in the development of obesity and its related metabolic complications. Final Decision: yes