system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Citrulline, Enzyme-Linked Immunosorbent Assay, Female, Glaucoma, Humans, Hydrolases, Immunohistochemistry, Male, Middle Aged, Optic Nerve, Protein-Arginine Deiminases, Tissue Donors.
user
Is peptidylarginine deiminase type 2 over expressed in the glaucomatous optic nerve? Context: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG).
assistant
This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline. Final Decision: yes