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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which of the following cell organelle is mainly involved during apoptosis?
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The correct answer is  Loss of mitochondrial function is seen during apoptosis. Mitochondrial membrane integrity is not maintained, causing the end of normal activity and release of cytochrome c into the cytoplasm where it activates proteolytic enzymes called caspases. The initial caspases activate a cascade of other caspases, resulting in protein degradation throughout the cell. Ref: Mescher A.L. (2010). Chapter 3. The Cell Nucleus. In A.L. Mescher (Ed), Junqueira's Basic Histology: Text & Atlas, 12e.