system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adolescent, Adult, Common Variable Immunodeficiency, Female, Humans, Immunoglobulin M, Male, Middle Aged, Mucous Membrane, Nasal Mucosa, Osteitis, Paranasal Sinuses, Radiography, Sinusitis, Young Adult.
user
Is reduced immunoglobulin M associated with sinus mucosal thickening , osteitis and sinus surgery in patients with common variable immunodeficiency? Context: Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. We performed a retrospective review by a blinded observer using the Lund-Mackay numerical scoring scale as well as a visual scale for remodeling changes in the paranasal sinus bone on CT scans in CVID patients. The sinus CT scans of 19 subjects (9 males, 10 females; median age at diagnosis 34 years) are described. There was an inverse relationship between serum IgM and sinus mucosal thickening as described by the Lund-Mackay scale (R = -0.6398; p = 0.0032). Osteitis of the paranasal sinus bone was almost exclusively found in patients with a reduced serum IgM level of less than 25 mg/dl (p = 0.0074).
assistant
This is the first study to show that sinus mucosal thickening on CT in patients with CVID is inversely related to serum IgM levels. Final Decision: yes