system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE. Meshes: Aneuploidy, Animals, Cross-Sectional Studies, DNA (Cytosine-5-)-Methyltransferases, DNA Methylation, Epigenesis, Genetic, Genotype, Haploinsufficiency, Heterozygote, Male, Mice, Sex Chromosome Aberrations, Spermatogonia, Stem Cells.
user
Does haploinsufficiency of the paternal-effect gene Dnmt3L result in transient DNA hypomethylation in progenitor cells of the male germline? Context: How does haploinsufficiency of the paternal-effect gene Dnmt3L affect DNA methylation establishment and stability in the male germline?
assistant
Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells. Final Decision: yes