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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, C-Reactive Protein, Cholesterol, LDL, Female, Humans, Insulin Resistance, Kidney Failure, Chronic, Logistic Models, Male, Middle Aged, Polyamines, Renal Dialysis, Sevelamer, Tunica Intima, Tunica Media, Ultrasonography, Vascular Calcification.
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Are c-reactive protein levels associated with arterial media calcification in nondiabetic patients with end-stage renal disease on long-term hemodialysis? Context: Vascular calcifications (VC) are associated with cardiovascular (CV) morbidity and are independent predictors of CV mortality in end-stage renal disease (ESRD). This study aimed to investigate the presence of arterial intima calcification (AIC) and arterial media calcification (AMC) in nondiabetic patients on long-term hemodialysis, and to assess the association with CV risk factors. 34 ESRD patients (17 males) on hemodialysis for at least 5 years were evaluated for VC using B-mode ultrasonography. AMC and AIC patterns were detected respectively in 62% and 59% of patients, and 21% had no VC. Patients with AIC were significantly older than those without AIC (p < 0.001). CRP levels (p < 0.001) were higher in patients with AMC. Using multivariate logistic analysis of regression, older age (> 50 years) and higher CRP levels (> 5 mg/l) were associated with AIC and AMC, respectively (p = 0.007 and p = 0.003). Logistic regression analysis showed that patients with CRP > 5 mg/l had a greater relative risk of having AMC (odds ratio 30, 95% confidence interval 27.041 - 32.959; p = 0.003).
assistant
Ultrasonography can be used to detect AIC and AMC, and could be useful for the early detection of VC. In nondiabetic patients who had been on hemodialysis for at least 5 years, older age was associated with AIC, and elevated CRP levels with AMC. Final Decision: yes