system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Bed Rest, Bone Density, Bone and Bones, Calcium, Case-Control Studies, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Heparin, Humans, Osteocalcin, Osteoporosis, Pregnancy, Pregnancy Complications, Pregnancy Complications, Cardiovascular.
user
Does short-term low-dose heparin plus bedrest impair bone metabolism in pregnant women? Context: To assess the osteoporotic risk of short-term low-dose heparin plus bedrest in pregnancy. In a prospective case-control study, 10 pregnant women on bedrest receiving prophylactic unfractionated heparin 10,000 IU per day for 7-46 days pre-study and 28 days per-study were compared with 6 normal pregnant controls of similar maternal and gestational age and 10 nonpregnant women of similar age. Serum ionised calcium, 1,25-dihydroxyvitamin D(3), osteocalcin, and urinary calcium/creatinine ratio were determined three times at 2-week intervals. 1,25-Dihydroxyvitamin D(3) was lower in the treated group than in pregnant controls throughout (P<0.03). Osteocalcin was lower at study start than end in both pregnant groups (P<0.05), and lower in the treated group than in either pregnant (n.s.) or nonpregnant controls (P<0.005). Calcium/creatinine ratio differences were non significant (n.s.).
assistant
Short-term low-dose heparin plus bedrest suppresses 1,25-dihydroxyvitamin D(3) and osteocalcin levels in pregnancy. Final Decision: yes