system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Aortic Diseases, Coronary Artery Disease, Diabetes Mellitus, Type 2, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Vascular Calcification.
user
Is progression of vascular calcification increased with statin use in the Veterans Affairs Diabetes Trial ( VADT )? Context: To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM). Progression of coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) was assessed according to the frequency of statin use in 197 participants with T2DM. After adjustment for baseline CAC and other confounders, progression of CAC was significantly higher in more frequent statin users than in less frequent users (mean ± SE, 8.2 ± 0.5 mm(3) vs. 4.2 ± 1.1 mm(3); P < 0.01). AAC progression was in general not significantly increased with more frequent statin use; in a subgroup of participants initially not receiving statins, however, progression of both CAC and AAC was significantly increased in frequent statin users.
assistant
More frequent statin use is associated with accelerated CAC in T2DM patients with advanced atherosclerosis. Final Decision: yes