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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, STUDY DESIGN, RESULTS. Meshes: Adult, Alleles, Asian Continental Ancestry Group, Case-Control Studies, DNA Primers, Female, Genetic Predisposition to Disease, Humans, Intercellular Adhesion Molecule-1, Polymerase Chain Reaction, Polymorphism, Genetic, Pre-Eclampsia, Pregnancy, Republic of Korea.
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Intercellular adhesion molecule-1 K469E polymorphism: Is it associated with preeclampsia in the Korean population? Context: To examine whether the distribution of genotypic and allelic frequencies of ICAM-1 K469 of Korean women with preeclampsia are different from that of a control group. In this case-control study the ICAM-1 K469E polymorphism was genotyped in 42 women with preeclampsia and 138 normotensive controls who had delivered at least two normal, term infants. A direct sequencing reaction method was used to detect a single nucleotide polymorphism. The distribution of genotype frequencies and the frequency of the K469 allele of the preeclampsia group were not significantly different from those of the controls. A similar trend was observed between the severe preeclampsia patients and the controls.
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The frequencies of the KK genotype and the K allele were higher in the preeclampsia group than those in the control group. However, there was no statistically significant difference.