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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE. Meshes: Adult, Alleles, Cohort Studies, DNA Methylation, Epigenesis, Genetic, Female, Fertilization in Vitro, Genomic Imprinting, Humans, Infant, Newborn, Infertility, Male, Ovulation Induction, Reproductive Techniques, Assisted, Transcription, Genetic.
user
Are methylation levels at imprinting control regions altered with ovulation induction or in vitro fertilization in a birth cohort? Context: Do fertility treatments, including ovulation induction (OI), alter epigenetic mechanisms such as DNA methylation at imprinted loci?
assistant
We observed small but statistically significant differences in certain imprinting control regions (ICRs) based on the method of conception, however, these small changes in methylation did not correlate to the overall transcriptional levels of the genes adjacent to the ICRs (such as KCNQ1 and SNRPN). Final Decision: no