system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 30-year-old woman presents to the emergency department in a state of confusion and disorientation that started this morning. She is accompanied by her husband who says that she has been unwell for about one week. She has been complaining of fatigue. Her husband says that this morning, she also complained that her urine was dark red in color and that there were some red spots over her legs. He did notice some changes in her level of consciousness that worsened over time and he decided to bring her in today. She does not have a significant medical history. Physical examination shows petechiae over her arms and legs. She is conscious but drowsy and disoriented and unable to answer the physician’s questions appropriately. Her temperature is 38.3°C (100.9°F), blood pressure is 160/100 mm Hg, pulse rate is 90/min, and respiratory rate is 20/min.
Laboratory studies show:
Hemoglobin 10 g/dL
Leukocyte count 9,000/mm3
Platelet count 30,000/mm3
Bleeding time 10 min
Prothrombin time 12 s
Activated partial thromboplastin time 30 s
D-dimer 0.4 mg/L (normal < 0.5 mg/L)
Serum fibrinogen 350 mg/dL (normal 200–400 mg/dL)
Serum bilirubin (indirect) 2.2 mg/dL
Serum creatinine 1.5 mg/dL
Serum LDH 1,010 U/L
Based on her history, and her physical and laboratory findings, which of the following is the most likely pathophysiology for her presentation?
assistant
Decreased ADAMTS13 causing platelet adhesion and formation of microthrombi