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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Biomarkers, Central Venous Pressure, Critical Illness, Extravascular Lung Water, Female, Hemodynamics, Hospitals, University, Humans, Intensive Care Units, Male, Middle Aged, Osmolar Concentration, Pulmonary Edema, Retrospective Studies, Risk Factors, Serum Albumin, Stroke Volume, Thermodilution.
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Are global end-diastolic volume , serum osmolarity , and albumin risk factors for increased extravascular lung water? Context: The transpulmonary thermodilution technique allows the determination of cardiac preload (global end-diastolic volume index) and quantification of pulmonary edema (extravascular lung water index [EVLWI]). Pulmonary edema commonly develops in critically ill patients; however, the underlying pathophysiology, that is, hydrostatic (cardiac) or permeability-induced (noncardiac), often remains unclear. In this study, hemodynamic and serum parameters of osmolarity and oncotic pressure were analyzed to identify risk factors for increased EVLWI. A retrospective, single-center analysis in an intensive care unit of a university hospital was performed. No interventions were made for the study. Forty-two critically ill patients were included, and 126 simultaneous hemodynamic measurements and serum determinations were analyzed by logistic regression and Spearman rank correlation coefficient analysis. Global end-diastolic volume index (P = .001), serum albumin (P = .006), and serum osmolarity (P = .029) were significant factors for increased EVLWI (defined as >10 mL/kg).
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Hypervolemia, hypoalbuminemia, and high plasma osmolarity are associated with increased EVLWI. Final Decision: yes