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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Electrooculography, Evoked Potentials, Visual, Eye Movements, Humans, Nystagmus, Pathologic, Photic Stimulation, Retina, Vision, Monocular.
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Does simulated nystagmus suppress pattern-reversal but not pattern-onset visual evoked potentials? Context: The aim of this study is to quantify and compare the effects of simulated horizontal nystagmus on pattern-reversal and pattern-onset visual evoked potentials (VEPs). In eight visually normal subjects with normal oculomotor behaviour, we monitored eye movements and recorded pattern-reversal and pattern-onset VEPs from occipital electrodes. Subjects viewed the stimulus monocularly via a mirror, which was placed close to the eye and driven by a scanner at four different amplitudes (0, 1, 2, and 3 degrees ) with a 4 Hz saw-tooth waveform to simulate horizontal jerk-nystagmus. Retinal image motion nearly abolished the pattern-reversal VEPs (maximal reduction by 85%; mean reduction by 72%, P<0.001), while there was a non-significant reduction (mean reduction by 15%) of the pattern-onset VEPs.
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The differential effect of simulated nystagmus on pattern-reversal and pattern-onset VEPs resembles that reported in studies on nystagmus patients. We conclude that the interaction of retinal image motion with the stimulus is sufficient to explain the reduction of pattern-reversal VEPs in patients with nystagmus and propose simulated nystagmus as a useful tool to test the influence of nystagmus on the efficiency of VEP stimuli. Final Decision: yes