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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Diabetes, Gestational, Female, Gestational Age, Glucose Intolerance, Glucose Tolerance Test, Humans, Intra-Abdominal Fat, Maternal Age, Obesity, Abdominal, Odds Ratio, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, First, Prospective Studies.
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Does first-Trimester Maternal Abdominal Adiposity predict Dysglycemia and Gestational Diabetes Mellitus in Midpregnancy? Context: This study assessed the association between first-trimester abdominal adiposity and dysglycemia and gestational diabetes mellitus (GDM) in midpregnancy. In a prospective cohort of 485 women, we measured subcutaneous (SAT), visceral (VAT), and total (TAT) adipose tissue depth, using ultrasound at 11-14 weeks' gestation. Logistic regression analysis assessed the relation between quartiles of SAT, VAT, or TAT depth and the composite outcome of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or GDM, based on a 75-g oral glucose tolerance test at 24-28 weeks. Adjusting for maternal age, ethnicity, family history of diabetes, and BMI, quartile 4 versus quartile 1 VAT (adjusted odds ratio [aOR] 3.1, 95% CI 1.1-9.5) and TAT (aOR 2.7, 95% CI 1.1-7.8) were significantly associated with the composite outcome, but SAT was not (aOR 1.8, 95% CI 0.70-4.8). The same was seen for GDM alone.
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Elevated first-trimester VAT and TAT depth independently predicted the risk of dysglycemia later in pregnancy. Final Decision: yes