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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: AMP Deaminase, Aged, Alleles, Asian Continental Ancestry Group, China, Cholesterol, Fatty Acid Desaturases, Fatty Acids, Female, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Genotyping Techniques, Humans, LIM-Homeodomain Proteins, Male, Middle Aged, Polymorphism, Single Nucleotide, Sphingosine N-Acyltransferase, Transcription Factors, Triglycerides, United States.
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Does meta-analysis of genome-wide association studies identify three novel loci for saturated fatty acids in East Asians? Context: We aimed to characterize common genetic variants that influence saturated fatty acid concentrations in East Asians. Meta-analysis of genome-wide association studies for circulating SFAs was conducted in two population-based cohorts comprising 3521 participants of Chinese ancestry. We identified two novel 14:0-associated loci at LMX1A (LIM homeobox transcription factor 1) and AMPD3 (AMP deaminase 3) (P = 5.08 × 10
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To our knowledge, this is the first GWAS analysis to examine SFA concentrations in East Asian populations. Our findings provide novel evidence that genetic variations of several genes from multiple pathways are associated with SFA concentrations in human body. Final Decision: yes