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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Collagen, Coronary Artery Disease, DNA Methylation, Epigenesis, Genetic, Epigenomics, Gene Ontology, Genome-Wide Association Study, Glycoproteins, Humans, Hyperlipoproteinemia Type II, Male, Matrix Metalloproteinase 9, Middle Aged.
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Does a study in familial hypercholesterolemia suggest reduced methylomic plasticity in men with coronary artery disease? Context: To assess whether DNA methylation is associated with coronary artery disease (CAD). An epigenome-wide analysis has been performed on leucocytes from familial hypercholesterolemic (FH) men with (n = 6) or without CAD (n = 6). The results were replicated in an extended sample of FH men (n = 61) and in non-FH men (n = 100) for two of the top differentially methylated loci. FH men with CAD had significantly more hypomethylated and hypermethylated loci and showed less DNA methylation level variability compared with men without CAD (p < 0.001). Moreover, COL14A1 and MMP9 DNA methylation levels were associated with CAD, age of onset of CAD or CAD risk factors.
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These results suggest that epigenome-wide changes are associated with CAD occurrence in men. Final Decision: yes