system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Carbon Radioisotopes, Creutzfeldt-Jakob Syndrome, Dopamine, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Iodine Radioisotopes, Magnetic Resonance Imaging, Putamen, Tomography, Emission-Computed, Single-Photon, Tropanes.
user
Does striatal [ 123I ] FP-CIT SPECT demonstrate dopaminergic deficit in a sporadic case of Creutzfeldt-Jakob disease? Context: The frequent occurrence of movement disorders such as myoclonus, parkinsonism and dystonia, strongly suggests an involvement of the dopaminergic system in sporadic Creutzfeldt-Jakob disease (sCJD), but this issue has not been specifically addressed yet. We report a patient who after a sub-acute focal clinical onset, developed the full clinical picture of probable sCJD. Given the early unilateral right extrapyramidal rigidity, the patient was assessed by single-photon emission computed tomography of the dopamine transporter (DAT) using [123I] FP-CIT. DAT-scan demonstrated reduced values of presynaptic receptorial trace in the putamen, particularly on the left side, consistent with functional putaminal dopaminergic presynaptic alteration.
assistant
The present observation emphasizes the possible role of DAT imaging studies in the investigation of the pathogenesis of movement disorders in CJD. Final Decision: yes