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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, RESULTS. Meshes: Aged, Aging, Female, Fibroblast Growth Factor 2, Follow-Up Studies, Guided Tissue Regeneration, Humans, Injections, Male, Middle Aged, Patient Satisfaction, Recovery of Function, Stroboscopy, Treatment Outcome, Vocal Cords, Voice Disorders, Voice Quality.
user
Does clinical trial of regeneration of aged vocal fold with growth factor therapy? Context: Aged vocal folds are characterized by atrophy of the mucosa, which causes mucosal wave deficiency and glottal insufficiency. This clinical trial examined the regenerative effects and safety considerations of basic fibroblast growth factor (bFGF) on restoration of aged vocal folds. Institutional review board-approved human clinical trial. Ten patients (6 men and 4 women; mean age, 70.1 years) were recruited in the trial. Ten micrograms of bFGF was injected into each treated vocal fold. Injection was performed unilaterally or bilaterally according to each patient's need and repeated up to seven times if necessary. Patient follow-up continued for at least 6 months. The effectiveness of the treatment was assessed by stroboscopic, acoustic, and aerodynamic measurements. All patients showed improvement of voice. Significant improvements in maximum phonation time, mean flow rate, jitter, shimmer, and noise-to-harmonic ratio lasted for at least 1 year. No allergic or long-term adverse effects were noted.
assistant
This clinical trial suggests that bFGF may be effective and safe as a regenerative agent for aged vocal folds. Final Decision: yes