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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Animals, Disease Models, Animal, Ear, Middle, Macrophages, Mice, Mice, Inbred C57BL, Mice, Knockout, Otitis Media, Pneumococcal Infections, Streptococcus pneumoniae, Toll-Like Receptor 2, Translational Medical Research, Up-Regulation.
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Does tLR2 promote macrophage recruitment and Streptococcus pneumoniae clearance during mouse otitis media? Context: The natural course of otitis media (OM) in most children is acute and self-limiting; however, approximately 10-20% of children can experience persistent or recurrent OM. Determining the host factors that influence outcome of OM will help us design better therapies. This study focused on the role of Toll-like receptor 2 (TLR2) in a pneumococcal OM mouse model. The middle ears (MEs) of wild-type (WT) and TLR2 TLR2 expression in ME mucosa was markedly enhanced following infection with Spn in WT mice. In contrast to WT mice, TLR2
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Our results demonstrate that TLR2 signaling is critical for bacterial clearance and timely resolution of inflammation in OM induced by Spn. Final Decision: yes