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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, CDC2-CDC28 Kinases, Diabetes Mellitus, Type 2, Diet, High-Fat, Disease Models, Animal, Eating, Energy Metabolism, Homeostasis, Hypothalamus, Insulin Resistance, Lipid Metabolism, Male, Mice, Obesity, Phosphorylation, Signal Transduction.
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Is cdc2-like kinase 2 ( CLK2 ) in the hypothalamus necessary to maintain energy homeostasis? Context: To investigate whether the Cdc2-like Kinase 2 (CLK2) is expressed in hypothalamic neurons and if it is, whether the hypothalamic CLK2 has a role in the regulation of energy balance. Swiss mice on chow or high fat diet (HFD) and db/db mice on chow diet were used to address the role of CLK2 in the hypothalamus. Hypothalamic CLK2
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Thus, our results suggest that protein CLK2 integrates some important hypothalamic pathways, and may be a promising molecule for new therapeutic approaches against obesity and diabetes.International Journal of Obesity accepted article preview online, 13 October 2016. doi:10.1038/ijo.2016.174. Final Decision: yes