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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Major contribution to cachexia with advanced cancer-
assistant
The correct answer is  Cachexia is not caused bu nutritional demands of the tumor. It is suspected that TNF produced by macrophages in response to tumor cells or by the tumor cells them self mediate cachexia. TNF mobilize fat from tissue stores and suppress appetite. ROBBINS