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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adipocytes, Animals, Anti-Inflammatory Agents, Non-Steroidal, Anticholesteremic Agents, Atorvastatin, Cells, Cultured, Cholesterol, Dietary, Gene Expression, Heptanoic Acids, Hypercholesterolemia, Interleukin-6, Male, Pyrroles, RNA, Messenger, Rabbits, Receptors, Cytoplasmic and Nuclear, Transcription Factors.
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Does atorvastatin reduce interleukin-6 plasma concentration and adipocyte secretion of hypercholesterolemic rabbits? Context: Interleukin-6 (IL-6) is secreted by adipocytes and may be involved in atherosclerosis. Few studies have assessed the influence of statins on IL-6 secretion in adipocytes. Rabbits on high-cholesterol diets were randomly given either atorvastatin 1.5 mg/kg day(-1) (n=5) or starch (n=5) for 2 weeks. Subcutaneous adipose was collected for adipocytes culture. IL-6 concentrations in plasma and adipocytes culture supernatant were measured by ELISA. RT-PCR was used to evaluate peroxisome proliferator-activated receptor (PPAR) gamma mRNA expression. The in vitro effect of atorvastatin on IL-6 production in adipocytes was observed. Two weeks atorvastatin treatment resulted in significant reduction of circulating IL-6 concentrations, which was associated with IL-6 secretion in adipocytes (r=0.849, P<0.01). Meanwhile mRNA expression of PPARgamma in adipocytes was intimately related to the IL-6 secretion in adipocytes (r=-0.900, P<0.01). Atorvastatin induced the decreased IL-6 secretion in dose-dependent manner.
assistant
Atorvastatin can inhibit IL-6 secretion in adipocytes possibly through upregulating PPARgamma, which may help to explain the anti-inflammatory effects of statins use. Final Decision: yes