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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Biopsy, Cells, Cultured, Colitis, Ulcerative, Crohn Disease, Female, Humans, Inflammation Mediators, Interleukin-8, Intestinal Mucosa, Leukocytes, Mononuclear, Male, Middle Aged, Organ Culture Techniques, Tumor Necrosis Factor-alpha.
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Is [ Interleukin-8 an important inflammatory mediator in hemorrhagic rectocolitis and Crohn disease ]? Context: The aim of the study was to assess in vitro the production of interleukin 8 in Crohn's disease and ulcerative colitis. Interleukin 8 concentrations (measured by ELISA) were evaluated in the culture supernatants of: a) peripheral blood mononuclear cells from 13 patients with Crohn's disease, 7 patients with ulcerative colitis and 7 controls, b) organ cultures of inflamed (22 Crohn's disease, 15 ulcerative colitis) and uninflamed (21 Crohn's disease, 9 ulcerative colitis, 15 controls) intestinal mucosal biopsies. In patients with Crohn's disease and ulcerative colitis, the production of interleukin 8 by peripheral blood mononuclear cells and inflamed mucosa was higher than in controls (P < 0.01) without statistical difference between Crohn's disease and ulcerative colitis. Interleukin 8 production by normal mucosa was not different between the 3 groups. Interleukin 8 concentrations in the supernatants of organ culture were positively correlated to an endoscopical and a histological inflammatory index as well as to tumor necrosis factor, interleukin 1 and 6 concentrations.
assistant
These results support the notion that interleukin 8 plays an important role in the pathogenesis of inflammatory bowel disease. Final Decision: yes