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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adenoviridae, Angiogenesis Inhibitors, Animals, Carcinoma, Hepatocellular, Cell Adhesion Molecules, Cell Line, Tumor, Cell Proliferation, Gene Expression Regulation, Neoplastic, Genetic Vectors, Humans, Intercellular Adhesion Molecule-1, Kringles, Liver Neoplasms, Experimental, Male, Matrix Metalloproteinase 9, Mice, Neoplasm Metastasis, Peptide Fragments, Plasminogen, Recurrence, Vascular Cell Adhesion Molecule-1.
user
Does plasminogen fragment K1-3 inhibit expression of adhesion molecules and experimental HCC recurrence in the liver? Context: There is no established adjuvant or neo-adjuvant treatment to curb tumor recurrence of hepatocellular carcinoma (HCC). Recent data showed that angiostatic factors can inhibit tumor cell adhesion to the endothelium and therefore recurrence/metastasis. We tested a potential preventive, pre-operative strategy using plasminogen kringles 1-3 (K1-3) to overcome this hurdle. Effects of K1-3 on the intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) expression was analyzed in vitro and in vivo on RNA and protein levels. Influence of K1-3 on HCC recurrence in the liver was analyzed in an orthotopic tumor model. K1-3 decreased ICAM expression in Hepa129 tumor cells and VCAM expression in SVEC4-10 endothelial cells in vitro. In vivo, ICAM was reduced in histological tumor sections. Preventive treatment with AdK1-3 inhibited experimental HCC recurrence and tumor growth in the liver.
assistant
We were able to show that K1-3 inhibits intrahepatic tumor recurrence. This novel aspect elucidates a possible approach to prevent HCC recurrence. Final Decision: yes