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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adipose Tissue, Animals, Atherosclerosis, Blood Glucose, Blood Pressure, Body Weight, C-Reactive Protein, Disease Models, Animal, Female, Glucose Tolerance Test, Humans, Hyperlipidemias, Insulin, Insulin Resistance, Intra-Abdominal Fat, Lipoproteins, Male, Mesentery, Metabolic Syndrome, Myocardial Infarction, Rabbits, Receptors, LDL.
user
Are myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits with mesenteric fat accumulation a novel animal model for metabolic syndrome? Context: To examine whether the myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit with visceral fat accumulation is a new animal model for human metabolic syndrome, we examined the relationship between mesenteric fat accumulation and insulin resistance, hyperlipidemia and atherosclerosis. Glucose tolerance tests were performed using adult (11- to 15-month-old) and middle-aged (17- to 21-month-old) WHHLMI rabbits fed standard chow restrictedly. In addition, lipoprotein lipid levels, serum C-reactive protein (CRP) levels, mesenteric fat weight and physical and physiological parameters were measured. Mesenteric fat was stained immunohistochemically. The mesenteric adipose tissue was positive for monoclonal antibodies against macrophages, C-reactive protein and monocyte chemoattractant protein. In adult rabbits, mesenteric fat correlated to aortic lesion area, insulin resistance, fasting immunoreactive insulin, serum CRP, abdominal circumference and body weight. In middle-aged rabbits, mesenteric fat correlated to lipoprotein lipid levels in addition to the parameters showing a significant correlation in adult rabbits, excluding aortic lesion area.
assistant
The WHHLMI rabbit with visceral fat accumulation is a new animal model for metabolic syndrome. Final Decision: yes