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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
All the following are TRUE about cholestasis of pregnancy EXCEPT
assistant
The correct answer is  INTRAHEPATIC CHOLESTASIS OF PREGNANCY Increases in sex steroid levels causes incomplete clearance of bile acids, which accumulates in plasma Mutations of the ABCB4 gene associated with progressive familial intrahepatic cholestasis, Also drugs causes cholestatic jaundice in pregnant women , like those taking azathioprine following renal transplantation. Hyperbilirubinemia is due to retention of conjugated pigment, but total plasma concentrations rarely exceed 4 to 5 mg/dL. Alkaline phosphatase is usually elevated even more so than in normal pregnancy. Serum aminotransferase levels are normal to moderately elevated but seldom exceed 250 U/L Liver biopsy shows mild cholestasis with bile plugs in the hepatocytes and canaliculi of the centrilobular regions, but without inflammation or necrosis.