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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Body Mass Index, Cardiovascular Diseases, Cholesterol, Cholesterol, HDL, Female, Humans, Indians, North American, Macrophages, Male, Risk Factors, Subcutaneous Fat, Abdominal, Triglycerides.
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Are markers of adipose tissue macrophage content negatively associated with serum HDL-C concentrations? Context: Adipose tissue macrophages are associated with adiposity and may play a role in obesity related co-morbidities. We examined whether abdominal subcutaneous adipose tissue macrophage content (ATMc) was associated with fasting serum total cholesterol (TC), high density lipoprotein (HDL-C) and triglycerides (TG) concentrations. 52 (35 male) of Pima Indians without diabetes participated in the study. ATMc was assessed by histochemistry (CD68+ cells) (Mphi) and gene expression of macrophage-specific markers including CD68, CSF1r, CD11b and CD11c. HDL-C was negatively associated with CD68, CSF1R, CD11b and CD11c expression (r=-0.31, p=0.02; r=-0.38, p<0.01; r=-0.40, p<0.01; r=-0.26, p=0.04, respectively). After adjustment for age, sex and BMI, the associations between HDL-C and CSF1R, CD11b were still significant (r=-0.31, p=0.01 and r=-0.3, p=0.02), but borderline for CD68 (r=-0.24, p=0.06).
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ATMc is associated with lower HDL-C independent of BMI indicating a link between ATMc and cardiovascular risk factors. Final Decision: yes