system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Cardiopulmonary Bypass, Coronary Artery Bypass, Endostatins, Female, Humans, Male, Middle Aged, Orthopedic Procedures, Postoperative Complications, Treatment Outcome, Wound Healing.
user
Does elective orthopedic and cardiopulmonary bypass surgery cause a reduction in serum endostatin levels? Context: Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels. Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA. Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.
assistant
Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing. Final Decision: yes