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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Age of Onset, Child, Child, Preschool, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Infant, Magnetic Resonance Imaging, Male, Neurosurgical Procedures, Sclerosis, Temporal Lobe, Treatment Outcome, Young Adult.
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Does presence of temporal gray-white matter abnormalities influence epilepsy surgery outcome in temporal lobe epilepsy with hippocampal sclerosis? Context: Temporal lobe gray-white matter abnormalities (GWMA) are frequent morphological aberrances observed on MRI in patients with temporal lobe epilepsy (TLE) in addition to hippocampal sclerosis (HS). To study the influence of temporal pole GWMA on clinical characteristics and seizure outcome in patients with HS operated on for TLE. A cohort of 370 patients undergoing surgery for intractable TLE was prospectively collected in an epilepsy surgery data base. Clinical characteristics and seizure outcome of all 58 TLE patients with identified HS and GWMA (group 1) were compared with those of a matched control group of 58 HS patients without GWMA (group 2). Both groups were further subdivided into patients undergoing transsylvian selective amygdalohippocampectomy (sAH) and anterior temporal lobectomy with amygdalohippocampectomy (ATL). The HS plus GWMA patients were significantly younger at epilepsy onset than those without GWMA. In the HS plus GWMA group, 41% of patients were younger than 2 years when they experienced their first seizure in contrast to only 17% of patients with pure HS (P = .004). Seizure outcome was not statistically different between the 2 groups: 75.9% of the patients in group 1 were seizure free (Engel class I) compared with 81% of patients in group 2. Seizure outcome in both groups was about equally successful with selective amygdalohippocampectomy and anterior temporal lobectomy (ns).
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Limited and standard resections in TLE patients with HS are equally successful regardless of the presence of GWMA. Final Decision: no