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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Animals, Carcinoma, Hepatocellular, Cell Line, Cell Proliferation, Cells, Cultured, Down-Regulation, Estrogen Receptor beta, Estrogens, Female, Humans, Janus Kinase 1, Liver Neoplasms, Macrophage Activation, Macrophages, Male, Mice, Mice, Inbred BALB C, STAT6 Transcription Factor, Signal Transduction.
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Does estrogen repress hepatocellular carcinoma ( HCC ) growth via inhibiting alternative activation of tumor-associated macrophages ( TAMs )? Context: Hepatocarcinoma cancer (HCC) occurs more often in men than in women, and little is known about its underlying molecular mechanisms. We identify that 17β-estradiol (E2) could suppress tumor growth via regulating the polarization of macrophages.
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Estrogen functions as a suppressor for macrophage alternative activation. Final Decision: yes