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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Adult Children, Alleles, Analysis of Variance, Chromosome Mapping, Cohort Studies, Cross-Sectional Studies, Data Interpretation, Statistical, Female, Genetic Linkage, Humans, Longitudinal Studies, Male, Multifactorial Inheritance, Quantitative Trait Loci, Quantitative Trait, Heritable, Regression Analysis, Reproducibility of Results.
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Does consistency of linkage result across exams and methods in the Framingham Heart Study? Context: The repeated measures in the Framingham Heart Study in the Genetic Analysis Workshop 13 data set allow us to test for consistency of linkage results within a study across time. We compared regression-based linkage to variance components linkage across time for six quantitative traits in the real data. The variance components approach found 11 significant linkages, the regression-based approach found 4. There was only one region that overlapped. Consistency between exams generally decreased as the time interval between exams increased. The regression-based approach showed higher consistency in linkage results across exams.
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The low consistency between exams and between methods may help explain the lack of replication between studies in this field. Final Decision: yes