system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Manish, a patient of hypothyroidism was prescribed thyroxine. Which of the following is the most reliable guide for adjustment of thyroxine dose in him?
assistant
The correct answer is  * TSH levels are elevated in a hypothyroid patient (because feedback inhibition by thyroid hormones is not present). * Administration of thyroid hormones (T3 and T4) decreases TSH by contributing to feedback inhibition. * If TSH levels are less than normal, it signifies overeatment whereas high TSH level suggests inadequate treatment.