system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 71-year-old female presents to the clinic with frequent and voluminous urination for 2 weeks. She is a new patient and does not have any medical records as she recently moved to the US from Europe to live with her grandson. When asked about any prior health issues, she looks confused and shows some medications that she takes every day which includes aspirin, omeprazole, naproxen, and lithium. Her grandson is accompanying her and adds that he has requested a copy of her medical records from her previous physician in Europe. The grandson states that she has been drinking about 4–5 L of water every day. Her temperature is 37°C (98.6°F), respirations are 15/min, pulse is 107/min, and blood pressure is 92/68 mm Hg. The physical examination is significant for dry mucous membranes. Laboratory evaluation reveals the following:
Plasma osmolarity (Posm) 310 mOsm/kg
Urine osmolarity (Uosm) 270 mOsm/kg
After 6 hours of water deprivation:
Plasma osmolarity (Posm) 320 mOsm/kg
Urine osmolarity (Uosm) 277 mOsm/kg
After administration of desmopressin acetate (DDAVP):
Plasma osmolarity (Posm) 318 mOsm/kg
Urine osmolarity (Uosm) 280 mOsm/kg
What is the most likely cause of this patient's condition?
assistant
Lithium