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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Adult, Blood Glucose, Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, Estriol, Female, Glucose Tolerance Test, Humans, Insulin, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor I, Pregnancy, Testosterone.
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Do testosterone levels in pregnant women correlate with the insulin response during the glucose tolerance test? Context: To evaluate the association between insulin/insulin-like growth factor I (IGF-I) systems and androgen levels in pregnancy. Prospective cohort study. Yale University School of Medicine. Pregnant women undergoing a 100-gram 3-hour glucose tolerance test (GTT). Serum samples collected during GTT were analyzed for insulin, androgens, free IGF-I, insulin-like growth factor-binding protein (IGFBP) 1, and estriol. Observing the relationship between insulin/IGFs and androgen levels. The insulin area under the curve (I(AUC)) during GTT correlated positively with total T and free T, but not with dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), or estriol. The peak insulin values (I(max)) during GTT also correlated positively with total T and free T, but not with DHEA, DHEAS, or estriol. There was no statistically significant correlation of T levels with free IGF-I, IGFBP-1, glucose, DHEAS, or estriol. Multiple linear regression analysis modeling showed that I(AUC) and I(max) did have a statistically significant correlation with free T levels.
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This study demonstrates for the first time that I(AUC) and I(max) measured in hyperinsulinemic states such as pregnancy correlate with T levels. In view of the lack of correlation between insulin and DHEAS or estriol, insulin-related T production during pregnancy is likely of ovarian origin. Final Decision: yes