system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: METHODS, RESULTS. Meshes: Animals, Anti-Bacterial Agents, Anti-Inflammatory Agents, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Finasteride, Humans, Male, Pilot Projects, Prostatitis, Rats, Rats, Wistar, Treatment Outcome, Urinary Tract Infections.
user
Does finasteride have a preventive effect on chronic bacterial prostatitis? Context: All drug pretreatments were conducted for 4 weeks, and then experimental CBP was induced by instillation of a bacterial suspension (Escherichia coli Z17 O2:K1;H-). After 4 weeks, results of microbiological cultures of prostate and urine samples as well as histological findings of the prostate in each group were analyzed. Finasteride significantly reduced bacterial infection and decreased inflammatory cell infiltration in prostatic tissue compared with the control group. The group given both finasteride and antibiotic showed a greater inhibition of bacterial infection in the tissue than those given either finasteride or antibiotic alone.
assistant
Our experiments suggest the possibility that finasteride has a preventive effect on development of CBP, although there is as yet no consensus on the mechanism of this effect.