system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Acantholysis, resulting from desmosome weakening by autoantibodies directed against the protein desmoglein, is the disease mechanism attributed to which of the following?
assistant
The correct answer is  In pemphigus vulgaris, autoantibodies attach to antigens (desmoglein) found in desmosomes that keep keratinocytes linked to each other. Cells eventually separate from each other (acantholysis), resulting in short-lived intraepithelial vesicles/bullae.