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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Blood Platelets, Coronary Thrombosis, Female, Humans, Inflammation Mediators, Leukocyte Common Antigens, Male, Middle Aged, Neutrophils, Percutaneous Coronary Intervention, Platelet Endothelial Cell Adhesion Molecule-1, Prospective Studies, ST Elevation Myocardial Infarction, Time Factors.
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Is inflammatory cell content of coronary thrombi dependent on thrombus age in patients with ST-elevation myocardial infarction? Context: ST-elevation myocardial infarction (STEMI) is typically caused by an occlusive coronary thrombus. The process of intracoronary thrombus formation is poorly understood. It is known that inflammatory cells play a role in the formation and resolution of venous thrombi, however their role in coronary thrombosis is not clear. We therefore analyzed inflammatory cells in thrombi derived from patients with STEMI in relation to histologically classified thrombus age. Thrombus aspirates of 113 patients treated with primary percutaneous coronary intervention were prospectively collected and classified (fresh, lytic, or organized) based on hematoxylin and eosin staining. The density of inflammatory cells neutrophils (MPO), monocytes/macrophages (CD68), lymphocytes (CD45), and the platelet area (CD31), were visualized using immunohistochemistry. Patients' history, medication, and laboratory data were registered. Fresh thrombi (76.1%) were the most abundant as compared to lytic (16.8%) and organized (7.1%) thrombi. Neutrophils were significantly less present in organized (169cells/mm
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The composition of inflammatory cells differs with thrombus age in thrombosuction material of STEMI patients that in part depends on patient age and medication. Final Decision: yes