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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Amphetamine-Related Disorders, Asian Continental Ancestry Group, Brain-Derived Neurotrophic Factor, Central Nervous System Stimulants, Diagnostic and Statistical Manual of Mental Disorders, Gene Frequency, Genotype, Humans, Methamphetamine, Polymorphism, Genetic, Psychoses, Substance-Induced, Thailand.
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Is bDNF ( Val66Met ) genetic polymorphism associated with vulnerability for methamphetamine dependence? Context: Association of the brain-derived neurotrophic factor (BDNF) genetic polymorphism rs6265 (Val66Met) with methamphetamine (METH) dependence and METH-induced psychosis was investigated in the Thai population. The rs6265 genotype was determined in 100 male METH-dependent subjects and 102 controls using a real-time PCR high-resolution melt (RT-PCR-HRM) assay. The rs6265 genotype demonstrated significant differences in distribution between METH-dependent subjects and controls in which the frequency of GG genotype versus A-allele carriers was associated with METH dependence. Moreover, a significant effect of genotype on the occurrence of psychosis was found, with a lower frequency of GG genotype associated with METH-induced psychosis.
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The present findings indicate that rs6265 is associated with METH dependence in the Thai population, with the GG genotype greater in METH-dependent subjects but reducing the emergence of METH-dependent psychosis. Final Decision: yes