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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Brain Damage, Chronic, Cognition Disorders, Decision Making, Disability Evaluation, Female, Frontal Lobe, Functional Laterality, Gyrus Cinguli, Humans, Judgment, Male, Memory Disorders, Mental Disorders, Motivation, Motor Cortex, Neuropsychological Tests, Prefrontal Cortex, Reaction Time.
user
Do regional frontal injuries cause distinct impairments in cognitive control? Context: Lesions of the frontal lobes may impair the capacity of patients to control otherwise intact cognitive operations in the face of ambiguous sensory input or conflicting possible responses. To address the question of whether focal lesions in different regions of the frontal lobes produced specific impairments in cognitive control. We evaluated 42 patients with chronic frontal lesions and 38 control subjects on a modified Stroop test that allowed measurement of reaction times and errors. Planned, stratified analyses permitted identification of discrete frontal lesions that are critical for impaired performance. Lesions of the left ventrolateral region produced an increased number of incorrect responses to distractors. Lesions of a large portion of the right superior medial region, including anterior cingulate, supplementary motor area (SMA), pre-SMA, and dorsolateral areas, caused a slow reaction time and a decreased number of correct responses to targets.
assistant
Lesions in two distinct frontal regions impair cognitive control for a Stroop task, and the mechanisms of impairment are specific to the region of injury. This is support for a general proposal that the supervisory system is constructed of distinct subsystems. Final Decision: yes