system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Administration, Oral, Angiogenesis Inducing Agents, Animals, Collagen, Dietary Supplements, Epithelial Cells, Fish Proteins, Hydroxyproline, Immunohistochemistry, Male, Neovascularization, Physiologic, Oncorhynchus keta, Peptide Fragments, Random Allocation, Rats, Rats, Sprague-Dawley, Regeneration, Skin, Skin Physiological Phenomena, Tensile Strength, Time Factors, Wound Healing.
user
Does oral administration of marine collagen peptides from Chum Salmon skin enhance cutaneous wound healing and angiogenesis in rats? Context: A wound is a clinical entity which often poses problems in clinical practice. The present study was aimed to investigate the wound healing potential of administering marine collagen peptides (MCP) from Chum Salmon skin by using two wound models (incision and excision) in rats. Ninety-six animals were equally divided into the two wound models and then within each model animals were randomly divided into two groups: vehicle-treated group and 2 g kg(-1) MCP-treated group. Wound closure and tensile strength were calculated. Collagen deposition was assessed by Masson staining and hydroxyproline measurement. Angiogenesis was assessed by immunohistological methods. MCP-treated rats showed faster wound closure and improved tissue regeneration at the wound site, which was supported by histopathological parameters pertaining to wound healing. MCP treatment improved angiogenesis and helped form thicker and better organised collagen fibre deposition compared to vehicle-treated group.
assistant
The results show the efficacy of oral MCP treatment on wound healing in animals. Final Decision: yes