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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Absorption, Animals, Extracellular Matrix Proteins, Glycoproteins, Hypophosphatemia, Familial, Kidney Tubules, Male, Phosphates, Phosphoproteins, Rats, Rats, Sprague-Dawley.
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Does matrix extracellular phosphoglycoprotein cause phosphaturia in rats by inhibiting tubular phosphate reabsorption? Context: Matrix extracellular phosphoglycoprotein (MEPE), first isolated from tumour-derived tissue from a patient with oncogenic hypophosphataemia, is a putative phosphatonin that has received much less attention than fibroblast growth factor-23. To date, its effect on renal tubular phosphate reabsorption remains undefined. A renal clearance study was performed in anaesthetized rats infused intravenously with a range of doses of MEPE. MEPE had no effect on glomerular filtration rate (inulin clearance) but caused rapid, dose-dependent increases in absolute and fractional phosphate excretion, wholly attributable to reduced phosphate reabsorption. At a maximal dose, MEPE increased fractional phosphate excretion more than 2-fold, whereas no change was observed in time controls.
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The results lend support to the hypothesis that MEPE contributes to the phosphaturia of oncogenic hypophosphataemia and of hypophosphataemic rickets. Final Decision: yes