system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Diet, Dietary Carbohydrates, Dioscorea, Diosgenin, Extracellular Signal-Regulated MAP Kinases, Fructose, Interleukin-1beta, Interleukin-6, JNK Mitogen-Activated Protein Kinases, Kidney, Kidney Diseases, MAP Kinase Signaling System, Male, Metabolic Syndrome, Mice, Inbred ICR, Mitogen-Activated Protein Kinases, NF-kappa B, Phytotherapy, Plant Extracts, Saponins, Tumor Necrosis Factor-alpha, Uric Acid, p38 Mitogen-Activated Protein Kinases.
user
Does protodioscin ameliorate fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway? Context: High dietary fructose can cause metabolic syndrome and renal injury. The effects of protodioscin on metabolic syndrome and renal injury were investigated in mice receiving high-dose fructose. Mice received 30% (w/v) fructose in water and standard chow for 6 weeks to induce metabolic syndrome and were divided into four groups to receive carboxymethylcellulose sodium, allopurinol (5 mg/kg) and protodioscin (5 and 10 mg/kg) continuously for 6 weeks, respectively. The glucose intolerance, serum uric acid (UA), blood urea nitrogen (BUN), creatinine (Cr), total cholesterol (TC), triglyceride (TG), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined. Protodioscin significantly improved glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Histological examinations showed that protodioscin ameliorated glomerular and tubular pathological changes. Protodioscin significantly reduced renal concentrations of IL-1β, IL-6 and TNF-α by inhibiting the activation of nuclear factor-κB, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase. In addition, the effect of protodioscin on the mitogen activated protein kinases (MAPK) pathway was examined.
assistant
Taken together, protodioscin is a potential drug candidate for high dietary fructose-induced metabolic syndrome and renal injury. Final Decision: yes