system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 69-year-old man comes to the physician because of progressive difficulty swallowing and a 5-kg (11-lb) weight loss over the past 3 months. He first had trouble swallowing solid foods and then also developed difficulty swallowing liquids over the past week. Endoscopy shows a large mass 3 cm proximal to the esophagogastric junction. Biopsy of the mass shows significant distortion of glandular architecture. Which of the following is the strongest predisposing factor for this patient's condition?
assistant
Visceral obesity