system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Pharmacokinetic characteristics of propranolol include Vd = 300 L/70 kg, C1 = 700 mL/min, and oral bioavailability f = 0.25. What is the dose needed to achieve a plasma level equivalent to a steady state level of 20 mg/L?
assistant
The correct answer is  LD = 300L x 20 mg/L / 0.25 = 6000 mg/0.25 = 24,000 mg or 24 mg Ref:- kd tripathi; pg num:-33