system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE. Meshes: B7-1 Antigen, CD40 Antigens, Cell Proliferation, Cell Survival, Contraceptive Agents, Female, Dendritic Cells, Female, Humans, Medroxyprogesterone Acetate, Monocytes, T-Lymphocytes, Toll-Like Receptor 3.
user
Does medroxyprogesterone acetate impair human dendritic cell activation and function? Context: Does medroxyprogesterone acetate (MPA) impair human dendritic cell (DC) activation and function?
assistant
In vitro MPA treatment suppressed expression of CD40 and CD80 by human primary DCs responding to Toll-like receptor 3 (TLR3) agonist stimulation (i.e. DC activation). Moreover, this MPA-mediated decrease in CD40 expression impaired DC capacity to stimulate T cell proliferation (i.e. DC function). Final Decision: yes