system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 32-year-old man comes to the emergency room because of severe breathlessness for the past few hours. Over the course of a few years, he has been treated for asthma by several physicians, but his symptoms have continued to progress. He doesn’t smoke and never did. Both his father who died at the age of 40 years and his uncle (father’s brother), died with chronic obstructive pulmonary disorder. He has never smoked in his life. His respiratory rate is 19/min and temperature is 37.0°C (98.6°F). On physical examination, the patient has significantly longer exhalation than inhalation. His expiratory time is longer than 6 seconds. Clubbing is present. Chest auscultation reveals bilateral crackles. Mild hepatomegaly is present. What is the most likely diagnosis?
assistant
α1-antitrypsin-deficiency