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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: PURPOSE, MATERIALS AND METHODS, RESULTS. Meshes: Adipose Tissue, Adiposity, Adult, Breast, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Reference Values, Reproducibility of Results, Sensitivity and Specificity, Young Adult.
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Comparing average breast fat content results from two different protocols at 1.5T and 3T: can the data be pooled? Context: To compare the total breast fat content computed from two separate studies, performed on different scanners and with different protocols, with the goal of defining a relationship to allow pooling the data. Twelve healthy volunteer women were scanned with two different protocols on the same day. The protocols differed in four important aspects: vendors (GE vs. Philips), scanner main magnetic field strengths (1.5T vs. 3T), pulse sequences (2D fast spin-echo vs. 3D spoiled gradient-echo), and water/fat separation techniques. The resulting water and fat maps were processed with in-house software to extract breast tissue slice-wise. Percent fat content was calculated for each breast, per subject. Total percent fat contents (averaged across both breasts) resulting from both protocols were plotted against each other, on a subject-by-subject basis, revealing a strong correlation (R(2)  > 0.99), with an overestimation of the fat content from Protocol 1 relative to Protocol 2. The proposed T2 TE-correction for Protocol 1 improves the correlation while decreasing the discrepancy between protocols.
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Total breast fat content of healthy women resulting from the two protocols can be pooled using a linear relationship. The proposed T2 TE-corrected Protocol 1 is expected to yield accurate fat content.