system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 27-year-old woman presented to the clinic with recurrent abdominal swelling and stunted growth relative to her siblings. She has a history of multiple blood transfusions in her childhood. She has a family history of jaundice in her father who was operated on for multiple gallbladder stones. The physical examination reveals a pale, icteric, small and short-statured young lady. On abdominal examination, the spleen was enlarged by 6 cm below the right costal margin, but the liver was not palpable. The ultrasound of the abdomen reveals multiple gallbladder stones. The laboratory test results are as follows:
Hb 9 g/dL
Hct 27%
WBC 6,200/mm3
Platelets 200,000/mm3
MCV 75 um3
MCHC 37 gm/dL
Reticulocytes 6.5%
A peripheral blood smear is presented in the image. The direct Coombs test was negative. The osmotic fragility test was increased. What is the most likely cause of her condition?
assistant
Hereditary spherocytosis