system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 66-year-old woman is brought to the emergency department because of fever, chills, night sweats, and progressive shortness of breath for 1 week. She also reports generalized fatigue and nausea. She has type 2 diabetes mellitus and hypothyroidism. Current medications include metformin, sitagliptin, and levothyroxine. She appears ill. Her temperature is 38.7° (101.7°F), pulse is 104/min, and blood pressure is 160/90 mm Hg. Examination shows pale conjunctivae and small nontender hemorrhagic macules over her palms and soles. Crackles are heard at both lung bases. A grade 2/6 mid-diastolic murmur is heard best at the third left intercostal space and is accentuated by leaning forward. The spleen is palpated 1–2 cm below the left costal margin. Laboratory studies show:
Hemoglobin 10.6 g/dL
Leukocyte count 18,300/mm3
Erythrocyte sedimentation rate 48 mm/h
Urine
Protein 1+
Blood 2+
RBCs 20-30/hpf
WBCs 0-2/hpf
An echocardiography shows multiple vegetations on the aortic valve. Blood cultures grow S. gallolyticus. She is treated with ampicillin and gentamicin for 2 weeks and her symptoms resolve. A repeat echocardiography at 3 weeks shows mild aortic regurgitation with no vegetations. Which of the following is the most appropriate next step in management?"
assistant
Colonoscopy