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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Abdominal Abscess, Adult, Anastomosis, Surgical, Anastomotic Leak, Colectomy, Colon, Colon, Sigmoid, Confidence Intervals, Crohn Disease, Cutaneous Fistula, Female, Humans, Ileum, Inflammation, Intestinal Fistula, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Retrospective Studies, Risk Factors, Time Factors, Young Adult.
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Are positive histological inflammatory margins associated with increased risk for intra-abdominal septic complications in patients undergoing ileocolic resection for Crohn 's disease? Context: Rates of postoperative complications are particularly high among patients with Crohn's disease. The aim of this study was to assess whether positive inflammatory histological margins, among other factors, pose a risk for intra-abdominal septic complications in patients with Crohn's disease undergoing ileocolic resection. A retrospective study of patient records, during 2000-2010, was conducted. This investigation was performed at a single medical center. Included were 166 individuals with Crohn's disease (85 males, mean age 35.6). Ileocolic resection with primary anastomosis was performed. The primary outcomes measured were postoperative intra-abdominal septic complications. Twenty-five patients (15%) developed intra-abdominal septic complications, including anastomotic leak, intra-abdominal abscesses and collections, and enterocutaneous fistulas. There were no postoperative deaths. Univariate analysis revealed that a long course of disease before surgery, an emergency surgery, steroid treatment of more than 3 months before surgery, additional sigmoidectomy, and positive surgical margins detected on histopathological examination were associated with intra-abdominal septic complications. In a multivariate analysis, only disease duration longer than 10 years (OR 4.575 (CI 1.592-13.142), p = 0.005), additional sigmoidectomy (OR 5.768 (CI 1.088-30.568), p = 0.04), and positive histological resection margins (OR 2.996 (CI 1.085-8.277), p = 0.03) were found to be independent risk factors.
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This study was limited by the incomplete data regarding preoperative albumin levels. Final Decision: yes