system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, RESULTS. Meshes: Animals, Autophagy, Cardiomyopathies, Dual-Specificity Phosphatases, Female, Heart, Humans, Lamin Type A, MAP Kinase Signaling System, Male, Mice, Mice, Inbred CBA, Mice, Transgenic, Mitogen-Activated Protein Kinase Phosphatases, Mutation, Missense, Myocardium.
user
Does dual specificity phosphatase 4 mediate cardiomyopathy caused by lamin A/C ( LMNA ) gene mutation? Context: Mutations in LMNA gene cause cardiomyopathy, for which mechanistic insights are lacking. Dusp4 expression is enhanced in hearts with LMNA cardiomyopathy, and its overexpression in mice causes it by activating AKT-mTOR signaling that impairs autophagy.
assistant
Dusp4 causes cardiac dysfunction and may contribute to the development of LMNA cardiomyopathy. Final Decision: yes