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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, STUDY DESIGN, RESULTS. Meshes: Anti-Infective Agents, Chorioamnionitis, Cytoplasmic Granules, Defensins, Female, Fetal Membranes, Premature Rupture, Gestational Age, Humans, Lactoferrin, Neutrophils, Placenta, Pregnancy, Sensitivity and Specificity, Time Factors.
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Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes? Context: Our purpose was to determine whether maternal plasma levels of neutrophil granule products are elevated in patients with chorioamnionitis after preterm premature rupture of membranes (PROM). Fifty-two patients between 24 and 34 weeks' gestation with preterm PROM were included. Plasma samples for defensins and lactoferrin were collected throughout latency. Fifty-two control subjects between 26 and 30 weeks' gestation were recruited for baseline levels. Mean control defensin levels were compared with mean defensin levels on admission (668 ng/mL vs 5665 ng/mL, P<.01). Mean defensin levels on admission in patients without chorioamnionitis were compared with those of patients in whom histologic chorioamnionitis developed (520 ng/mL vs 9163 ng/mL, P<.01). The same relationships were not demonstrated for lactoferrin. With use a defensin value of 1500 ng/mL on admission, the sensitivity is 76% and specificity is 94% in predicting histologic chorioamnionitis.
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Maternal plasma levels of defensins are markers of histologic chorioamnionitis in patients after preterm PROM.