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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Analysis of Variance, Animals, Blood Glucose, Body Weight, Eating, Female, Fetus, Glucose Clamp Technique, Hyperinsulinism, Insulin, Insulin Resistance, Lactic Acid, Litter Size, Physical Conditioning, Animal, Pregnancy, Pregnancy, Animal, Rats, Rats, Wistar.
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Does aerobic exercise during pregnancy revert maternal insulin resistance in rats? Context: To determine whether pregnancy modifies the effect of aerobic exercise on insulin responsiveness, female rats were mated or kept nonpregnant and exercised or not on a treadmill (10 degrees slope, 20 m.min-1) 5 d.wk-1 during a 20-min period that was increased progressively up to 70 min on the 19th d. On day 20, a hyperinsulinemic euglycemic clamp was performed with 0.8 IU insulin.h-1.kg-1 under conscious conditions. Food intake and body weight, circulating lactic acid, glucose, and insulin as well as fetal body weight and number were unaffected by the exercise protocol. The rate of glucose infusion required to maintain basal glucose levels during the clamp was similar in exercised and nonexercised virgin rats and significantly lower in pregnant than in virgin nonexercised rats. However, in exercised pregnant rats the glucose infusion rate was almost as high as in the exercised virgin rats.
assistant
The results show that although our aerobic exercise protocol does not affect insulin responsiveness in nonpregnant rats, it completely reverts the insulin resistance present in late pregnant rats. Final Decision: yes