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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Bariatric Surgery, Body Mass Index, Diabetes Mellitus, Type 2, Female, Glycemic Index, Humans, Incretins, Insulin, Insulin-Secreting Cells, Male, Middle Aged, Postoperative Period, Prospective Studies.
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Do adults with long-duration type 2 diabetes have blunted glycemic and β-cell function improvements after bariatric surgery? Context: This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery. Twenty-seven adults with short- (<5 years) and long-duration (≥10 years) type 2 diabetes received a mixed-meal tolerance test at baseline and 24 months postsurgery. Body weight, insulin sensitivity, first- and second-phase meal-stimulated insulin secretion, disposition index (i.e., DI or pancreatic β-cell function), and incretin responses were examined. Adults with short-duration type 2 diabetes had better HbA(1c), greater insulin secretory capacity, and greater DI compared with adults with long-duration type 2 diabetes, despite similar weight loss and incretin responses. Diabetes duration correlated with smaller improvements in HbA(1c) and DI but not weight loss.
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Enhanced β-cell function characterizes the effect of bariatric surgery in adults with diabetes for <5 years, independent of weight loss or incretins. Additional therapy postsurgery may be required to improve glycemia for people with long-standing type 2 diabetes. Final Decision: yes