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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Conditioning (Psychology), Corn Oil, Dietary Fats, Digestion, Eating, Fatty Acids, Food Preferences, Male, Mice, Mice, Inbred Strains, Oxidation-Reduction, Postprandial Period, Random Allocation, Sucrose, Taste, Thioglycolates.
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Does inhibition of fatty acid beta-oxidation attenuate the reinforcing effects and palatability to fat? Context: We investigated the effects of the energy signal on the reinforcing effects and palatability to fat in mice. To examine the effects of postingestive energy signal, mice were injected with 400 micromol/kg body mass of mercaptoacetate, a beta-oxidation blocker or with saline (control group). Reinforcing effects and palatability response were examined with the conditioned place preference and one-bottle tests, respectively. In conditioned place preference tests, the mercaptoacetate group exhibited reinforcing effects when offered a 40% sucrose solution, which is not metabolized by the beta-oxidation pathway, but not when offered 100% corn oil. The control group exhibited reinforcing effects when offered the sucrose solution and when offered corn oil. In one-bottle tests, the control group exhibited palatability to corn oil, but the mercaptoacetate group did not. Consumption of sucrose solution was identical for both groups.
assistant
These results suggest that postingestive energy signal influences the reinforcing effects and palatability of fat. Final Decision: yes