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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Electric Stimulation, Electroencephalography, Evoked Potentials, Somatosensory, Humans, Male, Median Nerve, Middle Aged, Somatosensory Cortex.
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Are high-frequency (600 Hz) oscillations in human somatosensory evoked potentials due to phase-resetting phenomena? Context: Median nerve somatosensory evoked potentials (SEP) contain a brief oscillatory wavelet burst at about 600 Hz (σ-burst) superimposed on the initial cortical component (N20). While invasive single-cell recordings suggested that this burst is generated by increased neuronal spiking activity in area 3b, recent non-invasive scalp recordings could not reveal concomitant single-trial added-activity, suggesting that the SEP burst might instead be generated by phase-reset of ongoing high-frequency EEG. Here, a statistical model and exemplary data are presented reconciling these seemingly contradictory results. A statistical model defined the conditions required to detect added-activity in a set of single-trial SEP. Its predictions were tested by analyzing human single-trial scalp SEP recorded with custom-made low-noise amplifiers. The noise level in previous studies did not allow to detect single-trial added-activity in the period concomitant with the trial-averaged σ-burst. In contrast, optimized low-noise recordings do reveal added-activity in a set of single-trials.
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The experimental noise level is the decisive factor determining the detectability of added-activity in single-trials. A low-noise experiment provided direct evidence that the SEP σ-burst is at least partly generated by added-activity matching earlier invasive single-cell recordings.