system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Antigens, CD, Antioxidants, Ascorbic Acid, Biomarkers, CD11b Antigen, Cell Adhesion Molecules, Female, GPI-Linked Proteins, Glutathione Disulfide, Granulocytes, Humans, Immunity, Innate, L-Selectin, Lipid Peroxidation, Male, Middle Aged, Monocytes, Neutrophils, Olive Oil, Parenteral Nutrition, Home, Plant Oils, Risk Factors, Selenium, Soybean Oil, Streptococcus pneumoniae.
user
Does long-term olive oil-based parenteral nutrition sustain innate immune function in home patients without active underlying disease? Context: It remains unclear whether impaired host defenses contribute to the increased risk for infectious complications seen in patients on home parenteral nutrition (HPN). The aim of this study was to compare the innate immune function of patients on olive oil-based HPN with that of healthy controls. Innate immune functions and (anti-)oxidant balance were studied in 20 patients on olive oil-based HPN without an active underlying immune-mediated disease (Clinoleic(®), ≥ 6 months; >3 times/week), and 21 age- and sex-matched healthy controls. Neutrophils of patients and controls had a similar capacity to eliminate Streptococcus pneumoniae. Also, levels of activation markers (CD66b, CD11b, CD62L) in granulocytes and monocytes, phorbol ester- and zymosan-induced neutrophil oxygen radical production were not different between patients and controls. No differences in (anti-)oxidant status were found, except for higher concentrations of oxidized glutathione and lower plasma selenium and vitamin C in patients compared to controls.
assistant
Compromised innate immune function does not seem to explain the increased risk for infectious complications in HPN patients using olive oil-based lipid emulsions. Final Decision: yes