system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal, Body Mass Index, Breast Neoplasms, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Factors, Tamoxifen, Treatment Outcome, Weight Gain.
user
Does bMI variation increase recurrence risk in women with early-stage breast cancer? Context: The prognostic role of BMI variation during and/or after treatments for early-stage breast cancer is still unknown. The χ(2) test was conducted to explore the correlation between breast cancer recurrence and BMI changes in 520 early-stage breast cancer patients. Cox proportional hazard models were used to analyze the association of BMI changes, baseline BMI, known prognostic factors and recurrences. BMI gain was significant determinant of recurrences (p = 0.0008). In multivariate analyses, BMI variation more than 5.71% was associated with higher rates of recurrences, as well as age less than 55 years, stage disease and molecular subtype.
assistant
Women who experience BMI gain after breast cancer may be at increased risk of poor outcomes. Final Decision: yes