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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: .
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Does 374 Modeling the Effects of Current Steering With Directional lead? Context: Directional deep brain stimulation (DBS) leads designed to preferentially stimulate structures radially about the DBS lead are currently under development. Recent publications have demonstrated the ability of these leads to obtain directional effects during acute testing in patients. Here we will use computational modeling to demonstrate that combining directional leads with Multiple Independent Current Control (MICC) will offer additional control over the shape of the Volume of Tissue Activated (VTA). A finite element model (FEM) for DBS using example directional lead geometry was developed (COMSOL) and used to calculate potentials in the space surrounding the lead. These potentials were then used to evaluate neural activation by using axon cable models (NEURON) following the methods of McIntyre et al. Further analysis was performed in MATLAB to visualize and characterize the effects of stimulation. Modeled threshold fields iso-surfaced at relevant stimulation levels demonstrates the ability of MICC to enable selection and shaping of field profiles that are not possible when using single source systems.
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Modeling results suggest additional clinical benefit may be achieved when coupling directional leads with MICC designs. These additional fields may result in clinical benefits for some patients, and further study will be needed to evaluate their effects. Final Decision: yes