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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Asian Continental Ancestry Group, China, DNA Mutational Analysis, Exons, Female, Genotype, Humans, Hypogonadism, Kisspeptins, Male, Middle Aged, Mutation, Polymorphism, Single Nucleotide.
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Are mutations in KISS1 responsible for idiopathic hypogonadotropic hypogonadism in Chinese patients? Context: To investigate whether mutations in the KISS1 gene are present in 170 Chinese patients with idiopathic hypogonadotropic hypogonadism (IHH). Mutational screening of the KISS1 gene was performed in 170 Chinese patients with IHH (133 male cases and 37 female cases) and 187 matched controls (94 males and 93 females). Two known single-nucleotide polymorphisms (SNP), c. 58G > A in exon 1 and c. 242C > G in exon 2, were identified. However, no difference of genotype and allelic frequencies between cases and controls was observed.
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The results suggest that mutations in the coding sequence of KISS1 are not common in patients with IHH in this Chinese population. Final Decision: no