system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Acanthosis nigricans can occur due to -
assistant
The correct answer is  Hyperplasia of stratum spinosum of the epidermis.
Hyperkeratosis → Thickening of Stratum corneum of epidermis (Cornification of epidermis).
Slight basal cell hyperpigmentation.