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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNASSIGNED. Meshes: Animals, Apoptosis, Bile Acids and Salts, Caspase 3, Caspase 8, Cholestasis, Disease Models, Animal, Epidermal Growth Factor, ErbB Receptors, Hepatocytes, Liver Cirrhosis, Male, Mice, Mice, Knockout, Mice, Transgenic, STAT3 Transcription Factor, Signal Transduction.
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Does epidermal growth factor signaling protect from cholestatic liver injury and fibrosis? Context: We have demonstrated that the signal transducer and activator of transcription 3 (STAT3) protects from cholestatic liver injury. Specific ablation of STAT3 in hepatocytes and cholangiocytes (STAT3
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STAT3 is a negative regulator of bile acid biosynthesis. STAT3 protects from bile acid-induced apoptosis and regulates EGFR expression. EGFR signaling protects from cholestatic liver injury and fibrosis. Final Decision: yes