system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 69-year-old man with metastatic colon cancer is brought to the emergency department because of shortness of breath, fever, chills, and a productive cough with streaks of blood for the past 5 days. He has a history of emphysema. The patient does not have abdominal pain or headache. He receives chemotherapy with 5-fluorouracil, leucovorin, and oxaliplatin every 6 weeks; his last cycle was 3 weeks ago. His temperature is 38.3°C (101°F), pulse is 112/min, and blood pressure is 100/70 mm Hg. Pulse oximetry on room air shows an oxygen saturation of 83%. A few scattered inspiratory crackles are heard over the right lung. His mucous membranes are dry. Cardiac examination is normal. Laboratory studies show:
Hemoglobin 9.3 mg/dL
Leukocyte count 700/mm3
Segmented neutrophils 68%
Lymphocytes 25%
Eosinophils 4%
Monocytes 3%
Platelet count 104,000/mm3
Serum
Glucose 75 mg/dL
Urea nitrogen 41 mg/dL
Creatinine 2.1 mg/dL
Galactomannan antigen Positive
Which of the following is the most appropriate initial pharmacotherapy?"
assistant
Voriconazole