system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
The nitrates which can undergo the ﬁrst-pass metabolism:
assistant
The correct answer is  Organic nitrates are lipid-soluble: well absorbed from buccal mucosa, intestines and skin. Ingested orally, all except isosorbide mononitrate undergo extensive and variable first pass metabolism in liver.They are rapidly denitrated by a glutathione reductase and a mitochondrial aldehyde dehydrogcnase.
 
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 587