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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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A sudden increase in total peripheral resistance has all of the following effect except:
assistant
The correct answer is  An increase in total peripheral resistance leads to an increase in mean arterial blood pressure (Mean arterial blood pressure = Cardiac output x Total peripheral resistance). Mean arterial blood pressure is a good measure of afterload, which is a measure of the force the heart must develop during ejection. An increase in total peripheral resistance therefore increases afterload. A sudden increase in total peripheral resist­ance momentarily reduces stroke volume and, there­fore, cardiac output. The reduced ejection leads to an increase in end-systolic volume and a subsequent increase in end-diastolic volume. In the long term, stroke volume is maintained because the left ventricle now develops a greater force of contraction (ventricular systolic pressure increases) and cardiac output returns to normal.