system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 33-year-old Caucasian female presents to her primary care provider for pruritus and shortness of breath. Over the past year, she has experienced mild progressive diffuse pruritus. She also reports that her skin seems "hard" and that it has been harder to move her fingers freely. She initially attributed her symptoms to stress at work as a commercial pilot, but when her symptoms began impacting her ability to fly, she decided to seek treatment. She has a history of major depressive disorder and takes citalopram. She smokes 1 pack per day and drinks socially. Her temperature is 98.6°F (37°C), blood pressure is 148/88 mmHg, pulse is 83/min, and respirations are 21/min. On exam, she appears anxious with increased work of breathing. Dry rales are heard at her lung bases bilaterally. Her fingers appear shiny and do not have wrinkles on the skin folds. A normal S1 and S2 are heard on cardiac auscultation. This patient's condition is most strongly associated with which of the following antibodies?
assistant
Anti-DNA topoisomerase I