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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNLABELLED, BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Aminopterin, Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Folic Acid Antagonists, Humans, Middle Aged, Mycosis Fungoides, Prognosis, Recurrence, Retrospective Studies, Survival Analysis.
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Is pralatrexate an effective treatment for relapsed or refractory transformed mycosis fungoides : a subgroup efficacy analysis from the PROPEL study? Context: Transformed mycosis fungoides (tMF) is an aggressive disease with a median survival of 12-24 months. In this retrospective analysis of 12 patients with tMF, treatment with pralatrexate resulted in an objective response of 25% per independent central review and 58% per investigator assessment. Pralatrexate was well tolerated, with no toxicity-related discontinuations, which makes this an additional option for tMF treatment. Transformed mycosis fungoides (tMF) is an aggressive disease, with poor prognosis and a median survival of 24 months. In the Pralatrexate in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma (PROPEL) study, 12 patients with tMF were treated with a median of 10 pralatrexate doses (starting dose of 30 mg/m(2)) administered weekly for 6 weeks in a 7-week cycle. The median number of prior systemic therapies was 3. This retrospective analysis showed that the objective response rate in this subgroup was 25% (n = 3) per independent central review and 58% (n = 7) per investigator assessment, with this discrepancy likely attributed to challenges with photodocumentation of cutaneous lesions. The median duration of response and the median progression-free survival were 2.2 and 1.7 months, respectively, per central review, whereas median duration of response was 4.4 months, and median progression-free survival was 5.3 months per investigator assessment. Median survival was 13 months. Grade 1-3 mucositis was reported in 7 (58%) patients. Grade 4 adverse events were fatigue (n = 1) and thrombocytopenia (n = 1). Pralatrexate was well tolerated, with no toxicity-related discontinuations.
assistant
Based on these results, pralatrexate may be a treatment option for patients with relapsed or refractory tMF. Final Decision: yes