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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, RESULTS. Meshes: Age of Onset, Angiotensin II, Animals, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Cell Movement, Cells, Cultured, Chemokine CCL2, Cytokines, Denervation, Gene Expression Regulation, Hypertension, Hypertension, Renal, Immunophenotyping, Integrin alpha4beta1, Kidney, Lectins, Macrophages, Male, NK Cell Lectin-Like Receptor Subfamily B, Nephritis, Nicotine, Norepinephrine, Prehypertension, Rats, Rats, Inbred SHR, Rats, Inbred WKY, Receptor, Angiotensin, Type 1, Receptor, Angiotensin, Type 2, alpha7 Nicotinic Acetylcholine Receptor.
user
Does nicotine mediate CD161a+ Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat? Context: Renal inflammation contributes to the pathophysiology of hypertension. CD161a We aimed to phenotype CD161a Studies used young SHR and WKY (Wistar-Kyoto) rats. Splenocytes and bone marrow cells were exposed to nicotine ex vivo, and nicotine was infused in vivo. Blood pressures, kidney, serum, and urine were obtained. Flow cytometry, Luminex/ELISA, immunohistochemistry, confocal microscopy, and Western blot were used. Nicotinic cholinergic activation induced proliferation of CD161a
assistant
A novel, inherited nicotinic cholinergic inflammatory effect exists in young SHR, measured by expansion of CD161a Final Decision: yes