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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Alleles, Asian Continental Ancestry Group, Case-Control Studies, China, Female, Genetic Predisposition to Disease, Humans, Plasminogen Activator Inhibitor 1, Polycystic Ovary Syndrome, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Risk.
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Is 4G/5G polymorphism of plasminogen activator inhibitor-1 gene associated with polycystic ovary syndrome in Chinese patients : a meta-analysis? Context: To date, case-control studies on the association between a single-nucleotide polymorphism (SNP) in the plasminogen activator inhibitor-1 (PAI-1) gene and polycystic ovary syndrome (PCOS) have provided controversial results. The electronic databases PubMed, Embase, Web of Science, and CNKI (China National Knowledge Infrastructure) were searched for studies to include in the present meta-analysis. The fixed effects and random effects models showed that the 4G allele was associated with a risk of PCOS compared with the 5G allele in Chinese patients (OR = 2.05; 95 % CI = 1.56-2.69), but not in Caucasian patients (OR = 1.05; 95 % CI = 0.81-1.37). The contrast of homozygotes and the recessive and dominant models produced the same pattern of results as the allele contrast.
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Our pooled data suggest evidence for a major role of PAI-1 gene 4G/5G polymorphism in the pathogenesis of PCOS among Chinese patients. Final Decision: yes