system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adiposity, Adult, Aged, Aged, 80 and over, Body Mass Index, Exercise, Female, Humans, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Linear Models, Male, Middle Aged, Nutrition Surveys, United States, Waist-Hip Ratio, Young Adult.
user
Does association of IGF axis hormones with waist-to-hip ratio vary by physical activity? Context: Insulin-like growth factor (IGF) axis hormones are associated with multiple chronic diseases. Reports of the relationship between adiposity and IGF-axis hormones vary widely. This study hypothesized that physical activity levels modify the association of IGF axis hormones with adiposity. Data from NHANES III were used to assess whether associations of adiposity, namely waist-to-hip ratio (WHR), with IGF axis hormones varied according to physical activity. Among those in the lowest physical activity quintile, WHR had a substantive inverse association: bioavailable IGF-I was 16% lower among those in the highest versus the lowest WHR quintiles among the least active subjects (p<0.001). By comparison, among those in the highest physical activity quintile, IGF-I did not vary by WHR.
assistant
The association of bioavailable IGF-1 with central adiposity differs among active versus inactive adults in the U.S.A. This has relevance to understanding previously reported benefits of physical activity among overweight individuals. Final Decision: yes