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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
All of the following enzymes involved in heme synthesis are found in the mitochondria, EXCEPT:
assistant
The correct answer is  Uroporphyrinogen decarboxylase which catalyze the conversion of Uroporphyrinogen III to Coproporphyrinogen III is located in the cytoplasm. All the other 3 enzymes ferrochelatase, protoporphyrinogen oxidase and coproporphyrinogen oxidase are found in the cytoplasm. Coproporphyrinogen oxidase catalyze conversion of Coproporphyrinogen III to Protoporphyrinogen III. Protoporphyrinogen oxidase catalyze conversion of Protoporphyrinogen III to Protoporphyrin III. Ferrochelatase catalyze conversion of Protoporphyrin III to heme by incorporating heme into protoporphyrin. Ref: Murray R.K. (2011). Chapter 31. Porphyrins & Bile Pigments. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds),Harper's Illustrated Biochemistry, 29e.