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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 74-year-old woman is brought by ambulance to the emergency department and presents with a complaint of excruciating chest pain that started about 45 minutes ago. The patient was sitting in the garden when she 1st noticed the pain in the upper abdomen. The pain has persisted and now localizes underneath of the sternum and the left shoulder. Milk of magnesia and aspirin were tried with no relief. The patient had previous episodes of chest pain that were of lesser intensity and rarely lasted more than 10 minutes. She is diabetic and has been managed for hypertension and rheumatoid arthritis in the past. On examination, the patient is breathless and sweating profusely. The vital signs include blood pressure 140/90 mm Hg and heart rate 118/min. The electrocardiogram (ECG) shows Q waves in leads V2 and V3 and raised ST segments in leads V2, V3, V4, and V5. Laboratory studies (including cardiac enzymes at 6 hours after admission show:
Hematocrit 45%
Troponin T 1.5 ng/mL
Troponin I 0.28 ng/mL
Creatine kinase (CK)-MB 0.25 ng/mL
The patient is admitted and started on analgesia and reperfusion therapy. She shows initial signs of recovery until the 6th day of hospitalization when she starts vomiting and complaining of dizziness. Physical examination findings at this time included heart rate 110/min, temperature 37.7°C (99.9°F), blood pressure 90/60 mm Hg. Jugular venous pressure is 8 cm. A harsh pansystolic murmur is present at the left lower sternal border. ECG shows sinus tachycardia and ST-segment elevation with terminal negative T waves. Laboratory studies show:
Hematocrit 38%
Troponin T 1.15ng/mL
Troponin I 0.18 ng/mL
CK-MB 0.10 ng/mL
Which of the following best explains the patient's current clinical condition?
assistant
Acute ventricular septal rupture complicating myocardial infarction