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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Calcitriol, Cancer-Associated Fibroblasts, Carcinoma, Cell Movement, Cells, Cultured, Collagen, Colorectal Neoplasms, Disease-Free Survival, Gene Expression, Humans, Kangai-1 Protein, Receptors, Calcitriol, S100 Calcium-Binding Protein A4, Survival Rate, Transcriptome, Vitamins.
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Do vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer? Context: Colorectal cancer (CRC) is a major health concern. Vitamin D deficiency is associated with high CRC incidence and mortality, suggesting a protective effect of vitamin D against this disease. Given the strong influence of tumour stroma on cancer progression, we investigated the potential effects of the active vitamin D metabolite 1α,25-dihydroxyvitamin D Expression of vitamin D receptor (VDR) and two 1,25(OH) High VDR expression in tumour stromal fibroblasts was associated with better overall survival (OS) and progression-free survival in CRC, independently of its expression in carcinoma cells. 1,25(OH)
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1,25(OH) Final Decision: yes