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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Asian Continental Ancestry Group, Autism Spectrum Disorder, Child, Child, Preschool, China, Ethnic Groups, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Group IV Phospholipases A2, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide.
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Does the rs251684 Variant of PLA2G4C be Associated with Autism Spectrum Disorder in the Northeast Han Chinese Population? Context: To investigate the association between autism spectrum disorder (ASD) and the phospholipase A2 group IVC (PLA2G4C) and phospholipase A2 group XIIA (PLA2G12A) polymorphisms in the Northeast Han Chinese population. A total of 68 family trios (children diagnosed with ASD and their unaffected parents) were enrolled. Five single-nucleotide polymorphisms (SNPs) (rs9226, rs1045376, rs251684, rs2307279, and rs156631) in PLA2G4C and four SNPs (rs6533451, rs2285714, rs2285713, and rs11728699) in PLA2G12A were selected and genotyped. The association between the SNPs and ASD was analyzed using the transmission disequilibrium test. Our results showed a significant association between ASD and the rs251684 variant of PLA2G4C (transmitted/nontransmitted = 36/21, χ
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The rs251684 polymorphism of PLA2G4C may be associated with ASD risk. Final Decision: yes