system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 40-year-old male patient presented to the dermatology OPD with complaints of a characteristic rash over the face along with fever, ahralgia and moderate chest pain. Patient gave history of using some drug for 3 months. On examination, there was no CNS involvement. Lab findings revealed normal urine r/m studies and normal RFTs. ANA and anti-histone antibody titres were found to be raised. Which of the following mechanisms is most likely implicated in the above disease: -
assistant
The correct answer is  This is a case of Drug induced Lupus. More common in females. Presents with the characteristic malar skin rash. Along with serositis, most commonly pleuritis. Kidney and CNS are rarely involved. Titres of anti-histone Abs are increased. It is a type 3 hypersensitivity reaction. It is associated with HLA-DR2 Image A shows Type 1 hypersensitivity reaction Image B shows Type 2 hypersensitivity reaction Image C shows Type 4 hypersensitivity reaction