system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Age of Onset, Alleles, Aneurysm, Ruptured, Austria, Chromatography, High Pressure Liquid, DNA Mutational Analysis, Elastin, Female, Genetic Heterogeneity, Genetic Predisposition to Disease, Germany, Haplotypes, Humans, Intracranial Aneurysm, Japan, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Rupture, Spontaneous, Subarachnoid Hemorrhage.
user
Are elastin polymorphism haplotype and intracranial aneurysms associated in Central Europe? Context: The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients. We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls. We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm.
assistant
Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan. Final Decision: no