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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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A physiologist is studying various mediators that modulate coronary circulation. He is particularly looking at mediators that are activated via the clotting cascade, primarily activated factor XII. He finds that when the clotting cascade starts, it leads to the activation of factor XII, which in turn activates the enzyme kallikrein. This enzyme activates high and low-molecular-weight precursors of certain mediators, which work by contracting the visceral smooth muscle while relaxing the vascular smooth muscle. They are primarily associated with hypersensitivity and can cause an increase in capillary permeability, pain, and mobilize leukocytes. Which of the following is the precursor protein for the mediators the physiologist is studying?
assistant
Kininogen