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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Anti-Inflammatory Agents, Antioxidants, Biomarkers, Cytokines, DNA Damage, Disease Models, Animal, Ghrelin, Inflammation Mediators, Myelitis, Nerve Degeneration, Nerve Growth Factors, Neurons, Neuroprotective Agents, Oxidative Stress, Paralysis, Peroxidase, Phosphopyruvate Hydratase, Rats, Rats, Wistar, S100 Calcium Binding Protein beta Subunit, S100 Proteins, Spinal Cord, Spinal Cord Injuries, Treatment Outcome.
user
Does ghrelin alleviate spinal cord injury in rats via its anti-inflammatory effects? Context: Spinal cord injury (SCI) leads to an inflammatory response that generates     substantial secondary damage within the tissue besides the primary damage.     Ghrelin, 28 amino-acid peptide, has been shown to modulate the release of     proinflammatory cytokines and exert antiinflammatory effects. The aim of the     current study was to investigate the anti-inflammatory effects of ghrelin, in a     rat model of SCI. Wistar albino rats were divided as     control, SCI, and ghrelin-treated (10 μg/kg/day, ip) SCI groups. In order     to induce SCI, a standard weight-drop method that induced a moderately severe     injury (100 g/cm force) at T10, was used. Injured animals were given either     ghrelin or saline 15 min post-injury. In plasma samples,     neuron-specific enolase (NSE) and S-100β protein levels were evaluated.     Spinal cord samples were taken for histological examination or determination of     myeloperoxidase (MPO) activity and DNA fragmentation. SCI caused significant     increases in plasma NSE and S-100β levels and tissue MPO activity and DNA     damage. On the other hand, ghrelin treatment improved histological findings as     well as biochemical parameters while it failed to improve the impairment of the     neurological functions due to SCI.
assistant
The present study suggests that     ghrelin could reduce SCI-induced oxidative stress and exert anti-inflammatory     effects in the spinal cord following trauma. Final Decision: yes