system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Alginates, Animals, Antibodies, Heterophile, Blood Glucose, C-Peptide, Capsules, Diabetes Mellitus, Experimental, Glucuronic Acid, Glycated Hemoglobin A, Graft Survival, Hexuronic Acids, Immunosuppression, Insulin, Islets of Langerhans Transplantation, Macaca fascicularis, Subcutaneous Tissue, Sus scrofa, Time Factors, Transplantation, Heterologous.
user
Does alginate macroencapsulation of pig islets allow correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression? Context: This study assessed the capacity of alginate-encapsulated islets to reverse diabetes in a pig-to-primate model. Adult pig islets were encapsulated in microcapsules implanted under the kidney capsule (n=4) or in a subcutaneous macrodevice (n=5) in diabetic primates. Fasting blood glucose (FBG), insulin, porcine C-peptide, glycosylated hemoglobin (HbA1C), and cellular and humoral responses were followed. Nonencapsulated pig islets were rejected within 7 days. A transient decrease of FBG was observed only during the 2 weeks after microencapsulated pig islet implantation under the kidney capsule. After subcutaneous transplantation of a macrodevice, diabetes was corrected up to a maximum of 6 months in five animals: FBG less than 107 mg/dL and HbA1C at 8% ± 1.4%. Two of the five animals received a new macrodevice between 25 and 35 weeks after the first graft dysfunction (HbA1C ≥ 13), and diabetes was controlled for an additional 18 weeks in these animals. Although a strong humoral response was elicited after transplantation of encapsulated islets, a total impermeability of alginate 3% wt/vol to IgG was demonstrated before and up to 20 weeks after transplantation of the subcutaneous macrodevice.
assistant
Pig islets encapsulated in a subcutaneous macrodevice can control diabetes up to 6 months without immunosuppression. Final Decision: yes