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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which of the following condition is associated with an increased risk of developing adenocarcinoma of esophagus?
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The correct answer is  The metaplasia of esophageal squamous epithelium to columnar epithelium (Barrett's esophagus) is a complication of severe reflux esophagitis, and is a risk factor for esophageal adenocarcinoma. Endoscopic biopsy is the gold standard for confirmation of Barrett's esophagus. The hallmark of Barret's esophagus is the presence of mucus secreting goblet cells. Ref: Schwaz's Principles of Surgery, 9th Edition, Chapter 25