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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Angioplasty, Balloon, Coronary, Blood Flow Velocity, Cardiovascular Agents, Chi-Square Distribution, Coronary Angiography, Coronary Artery Disease, Coronary Circulation, Coronary Restenosis, Drug-Eluting Stents, Female, Humans, Japan, Male, Middle Aged, Prosthesis Design, Regression Analysis, Risk Assessment, Risk Factors, Sirolimus, Stress, Mechanical, Time Factors, Treatment Outcome.
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Do low coronary flow velocity and shear stress predict restenosis after sirolimus-eluting stent implantation? Context: This study sought to assess predictive values of coronary flow velocity and an index of shear stress throughout the vessel for angiographic restenosis after sirolimus-eluting stent implantation. The study patients underwent successful implantation of a sirolimus-eluting stent for de novo lesions located in native coronary vessels and underwent follow-up angiography 6-9 months later. The TIMI frame count method and quantitative digital angiographic analysis were performed based on the post-stenting angiogram. Coronary flow velocity and Reynolds number, an index of shear stress, were measured. Post-stenting digital angiograms from 267 patients were analyzed. We divided the study patients into two groups: a Restenosis group with 21 patients and a Non-Restenosis group with 246 patients. The Restenosis group indicated significantly lower coronary flow velocity (137.7+/-35.6 mm/sec versus 241.1+/-72.9 mm/sec, p = 0.0001) and lower Reynolds number (107.0+/-35.8 versus 199.2+/-67.1, p = 0.0001) than did the Non-Restenosis group.
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Lowered coronary flow velocity and shear stress after sirolimus-eluting stenting may predict the risk of restenosis. Final Decision: yes