system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Amidohydrolases, Arginine, Cross-Sectional Studies, Czech Republic, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Disease Progression, Female, Follow-Up Studies, Humans, Male, Methylation, Middle Aged, Multivariate Analysis, Polymorphism, Single Nucleotide, Predictive Value of Tests, Prognosis, Reproducibility of Results, Risk Factors.
user
Are aDMA , SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms reliable predictors of diabetic nephropathy progression as identified by competing risk analysis? Context: Complex interplay of genetic and (patho)physiological factors influence availability of nitric oxide during the development and progression of diabetic complications. We assessed predictive value of commonly studied methylated asymmetric and symmetric dimethylarginines (ADMA and SDMA) and selected single nucleotide polymorphisms (SNPs) in dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes for the progression of diabetic nephropathy (DN). A total of 341 type 1 and type 2 diabetes patients with variable degree of kidney disease were included at baseline. Plasma levels of ADMA, SDMA and L-arginine were measured and six tagging SNPs in DDAH1 and 2 were determined. Progression of DN was defined as a transition from any given stage to a more advanced stage of albuminuria. Competing risk analysis was applied. Plasma levels of ADMA and SDMA significantly correlated with GFR. No significant genotype-phenotype relationship was ascertained for ADMA and DDAH variants, but SNP rs805304 exhibited marginally significant association with DN. ADMA, SDMA and L-arginine/ADMA ratio standardised to GFR were identified as significant predictors of DN progression but not GFR decline using multivariate competing risk analysis.
assistant
In our study we confirmed potentially significant role of ADMA and SDMA for the assessment of risk of DN progression in European diabetic population. Final Decision: yes