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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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'Knudson's two-hit' hypothesis is associated with-
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The correct answer is  Harshmohan textbook of pathology 7th edition. Familial retinoblastoma comprises 40% of cases and may be bilateral . In this cases all somatic cells inherit one mutant RBgene from a carrier parent. Later during life the other mutational event of 2nd allele affecting the somatic cells occurs. This forms the basis of two hot hypothesis given by Knudson in 1971..