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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: METHODS, RESULTS. Meshes: Antipsychotic Agents, Clozapine, Delayed-Action Preparations, Drug Resistance, Female, Humans, Leukocyte Count, Neutropenia, Neutrophils, Quetiapine Fumarate, Schizophrenia, Young Adult.
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Quetiapine XR-induced neutropenia: is a clozapine trial still possible for treatment-resistant schizophrenia? Context: We present the case of a young woman treated with clozapine at a first-episode psychosis clinic after a moderate quetiapine XR-induced neutropenia (0,5-1,0 × 10(9)  L(-1) ). The patient was successfully treated with clozapine and lithium, with less psychotic symptoms and a better level of functioning. The neutrophil count remained normal during the treatment period, which has been longer than a year.
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The outcome of this case supports the notion that clinicians could consider introducing clozapine in treatment-refractory patients who have a history of quetiapine XR-induced neutropenia, with close blood monitoring. Lithium co-administration may play a role in maintaining a normal neutrophil count.