system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Biomarkers, Tumor, Carcinoma, Down-Regulation, Female, Gene Expression Regulation, Neoplastic, Humans, MicroRNAs, Middle Aged, Neoplasm Recurrence, Local, Ovarian Neoplasms, Prognosis, Risk Factors.
user
Does miR-335 represent an independent prognostic marker in epithelial ovarian cancer? Context: To investigate the clinical significance of miR-335 expression in epithelial ovarian cancer (EOC). Expression of miR-335 in normal ovaries, EOC, and omental metastases was determined by quantitative realtime polymerase chain reaction. Overall survival (OS) and relapse-free survival (RFS) were examined using KaplanMeier curves and the Cox proportional hazards regression model. miR-335 expression level was reduced in malignant tissue samples, especially in omental metastases. Low miR-335 levels in EOC were associated with shorter OS (P < .001) and RFS (P = .002). In the multivariate analyses, low miR-335 levels emerged as an independent prognostic factor for poor OS (P = .005) and RFS (P = .016). miR-335 was downregulated in the recurrence group compared with the nonrecurrence group. The area under the receiver operating characteristic curve was 0.818 (95% confidence interval, 0.675-0.961).
assistant
Our results indicate that miR-335 relates to the prognosis of patients with EOC and is a promising predictor of EOC recurrence. Final Decision: yes