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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Cuspid, Enzyme-Linked Immunosorbent Assay, Gingival Crevicular Fluid, Humans, Interleukin-1beta, Tooth Movement Techniques, Vibration, Young Adult.
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Does vibratory stimulation increase interleukin-1 beta secretion during orthodontic tooth movement? Context: To investigate the effects of application of vibratory stimuli on interleukin (IL)-1β secretion during maxillary canine distalization. Split-mouth design study in 15 subjects (mean age, 22.9 years; range 19-25 years) whose bilateral maxillary first premolars were extracted with subsequent canine distalization. On the experimental side, light force (60 g) was applied to the canine for 3 months in combination with vibratory stimuli provided using an electric toothbrush 15 minutes a day for 2 months; only orthodontic force was applied to the contralateral control canine. Gingival crevicular fluid (GCF) was collected from the mesial and distal sides of each canine at each monthly appointment. IL-1β levels were analyzed using an enzyme-linked immunosorbent assay. Canine movement was measured monthly. Overall, enhanced IL-1β secretion was observed at the pressure sites of experimental canines compared to control canines (mean, 0.64 ± 0.33 pg/µL vs 0.10 ± 0.11 pg/µL, respectively, P < .001). The accumulative amount of tooth movement was greater for the experimental canine than for the control canine (mean, 2.85 ± 0.17 mm vs 1.77 ± 0.11 mm, respectively, P < .001).
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This study demonstrates that, in combination with light orthodontic force, application of vibratory stimuli using an electric toothbrush enhanced the secretion of IL-1β in GCF and accelerated orthodontic tooth movement. Final Decision: yes