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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Recent oral direct thrombin inhibitor which can be used for prevention of stroke is:
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The correct answer is  Ans. (A) Dabigatran:(Ref: Katzung 11/e p594, CMDT 2012/537, KDT 8/e p671,672)Ximelagatran was the first oral direct thrombin inhibitor approved; however it was later withdrawn because of hepatotoxicity. Recently a new direct thrombin inhibitor dabigatran has been approved for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation. It is administered as a prodrug; dabigatran etexilate. It is not metabolized by CYP enzymes however dose adjustment is required in renal failure.