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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Antifibrinolytic Agents, Arthroplasty, Replacement, Knee, Blood Loss, Surgical, Edema, Female, Fibrinolysis, Humans, Injections, Intra-Articular, Knee Joint, Male, Osteoarthritis, Knee, Prospective Studies, Tranexamic Acid, Treatment Outcome.
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Reduces intra-articular injection of tranexamic acid only blood loss but also knee joint swelling after total knee arthroplasty? Context: This is a randomised controlled trial to examine whether intra-articular injection of tranexamic acid (TXA) decreases blood loss, as well as reducing leg swelling after total knee arthroplasty (TKA). We performed 100 TKA in osteoarthritis patients. At closure, a total of 2,000 mg/20 ml TXA was injected into the knee joint through a closed suction drain (TXA group). For the control group, the same volume of physiological saline was injected. The pre-operative condition of the patients, post-operative haemoglobin (Hb) levels, discharge volumes from drain, D-dimer and needs for transfusion were compared between these two groups. Furthermore, leg diameters (thigh, suprapatellar portion and calf girth) were measured pre- and post-operatively to investigate whether TXA has an influence on leg swelling after surgery. The results revealed that post-operative decrease in Hb level was significantly reduced in the TXA group. Furthermore, knee joint swelling after operation was significantly suppressed in the TXA group compared to the control group.
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The results revealed intra-articular administration of TXA decreased not only blood loss, but also knee joint swelling after TKA. Final Decision: no