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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A Patient on alcohol dependence was given a drug and was advised to avoid alcohol as drug interaction would lead to adverse drug reaction. Which of the following is the drug
assistant
The correct answer is  When alcohol is ingested by a person who is on disulfiram, alcohol-derived acetal de hyde cannot be oxidised to acetate and this leads to an accumulation of acetaldehyde in blood. This causes the impoant disulfiram-ethanol reaction (DER) characterised by flushing, tachycardia, hypotension, tachypnoea, palpitations, headache, sweating, nausea, vomiting, giddiness and a sense of impending doom associated with severe anxiety. Ref: A Sho Textbook of Psychiatry, Niraj Ahuja, 7th Edition, pg. no.41