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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: 17 alpha-Hydroxyprogesterone Caproate, Animals, Enzyme Inhibitors, Female, Hydroxyprogesterones, Medroxyprogesterone Acetate, Mice, Mice, Inbred ICR, NG-Nitroarginine Methyl Ester, Nitric Oxide, Nitric Oxide Synthase, Pregnancy, Pregnancy, Animal, Premature Birth, Progesterone, Progestins.
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Do progestational agents prevent preterm birth induced by a nitric oxide synthesis inhibitor in the mouse? Context: The ability of the nitric oxide (NO) synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) to induce preterm parturition in the mouse has been previously documented. The present study tested the ability of progestational agents to prevent preterm birth induced by L-NAME. L-NAME was administered subcutaneously at 90 mg/kg on gestation day 16. Progesterone, medroxyprogesterone acetate and hydroxyprogesterone caproate were administered subcutaneously at 0 (vehicle), 5 or 10 mg/kg on gestation day 16 one hour before L-NAME and on day 17. Parturition was considered preterm if occurring before gestation day 18. Following treatment with L-NAME alone, 56.5% of the pregnant animals delivered before term. Treatment with progesterone, medroxyprogesterone acetate or hydroxyprogesterone caproate at 5 mg/kg or 10 mg/kg significantly and comparably reduced the rate of preterm birth caused by L-NAME.
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Progestational agents are able to reduce preterm births induced by nitric oxide synthase (NOS) inhibition. Final Decision: yes