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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adenocarcinoma, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Autopsy, Carboplatin, Carcinoma, Large Cell, Carcinoma, Small Cell, Carcinoma, Squamous Cell, Cells, Cultured, DNA Probes, Drug Resistance, Multiple, Female, Gene Expression Regulation, Neoplastic, Humans, Leukocytes, Mononuclear, Lung, Lung Neoplasms, Male, Middle Aged, Neoplasm Proteins, Polymerase Chain Reaction, RNA, Messenger, Transcription, Genetic, Tumor Cells, Cultured, Vault Ribonucleoprotein Particles.
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Is expression of lung-resistance protein gene associated with platinum drug exposure in lung cancer? Context: Platinum drug resistance is an important problem in lung cancer chemotherapy. In this study, we examined lung-resistance protein (LRP) gene expression in vivo and in vitro in relation to platinum drug exposure. The expression levels of the LRP gene were assessed by the reverse transcription polymerase chain reaction, in 80 autopsy samples (40 lung tumors and 40 corresponding normal lung tissues), two lung cancer cell lines and in peripheral mononuclear cells collected from 8 lung cancer patients before and after platinum drug administration. The LRP gene expression levels of autopsy specimens exposed antemortem to platinum drugs were not significantly different to those of specimens without platinum drug exposure, for both lung tumors and normal lung tissues. Our results also demonstrate that LRP gene expression was not induced by platinum drugs either in vitro or in vivo.
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The present results indicate that LRP gene expression is not associated with platinum drug exposure in lung cancer. Final Decision: no