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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Gluten-sensitive enteropathy is most strongly associated with –
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The correct answer is  Almost all individuals with celiac disease share the major histocompatibility complex II HLA-DQ2 or HLA-DQ8.
Gliadin is deamidated by the enzyme transglutaminase and deamidated gliadin peptides bind to DQ2 and DQ8.
Recognition of these peptides by CD4+ T cells leads to secretion of IFN-γ, which damages the intestinal wall.