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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Algorithms, Aquaporin 5, Biomarkers, Cohort Studies, Creatinine, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Enzyme-Linked Immunosorbent Assay, Glycated Hemoglobin A, Humans, Male, Middle Aged, Pilot Projects, Prognosis, Renal Insufficiency, Risk Factors, Sensitivity and Specificity, Severity of Illness Index.
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Is urine AQP5 a potential novel biomarker of diabetic nephropathy? Context: To investigate if urinary AQP5 serves as a new potential biomarker of diabetic nephropathy. Using an AQP5-specific enzyme-linked immunosorbent assay, we measured serum and urine AQP5 first in a cohort consisting of normal controls (n=26) and patients with diabetes mellitus (n=25) or diabetic nephropathy (n=33) and then in a validation cohort possessing normal controls (n=10), patients with diabetes mellitus (n=10) or diabetic nephropathy (n=14), and patients with chronic kidney disease of unknown etiology (n=10). We used various statistical methods including Pearson's correlation coefficient, ANOVA with Holm-Sidak test, Receiver Operator Curve, and multiple logistic regression to analyze the data. Urine AQP5/creatinine 1) is significantly higher in diabetic nephropathy than in other two groups, and in diabetic nephropathy stage V than in stage III; 2) correlates with serum creatinine, urine albumin, and multiple other known risk factors of the disease; and 3) improves the clinical models in distinguishing diabetic nephropathy from normal controls and diabetic mellitus.
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Our data suggest that urine AQP5/creatinine may possess diagnostic and prognostic values as a biomarker of diabetic nephropathy. Final Decision: yes