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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Binding Sites, Cell Line, Tumor, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Forkhead Box Protein O1, Forkhead Transcription Factors, Humans, Liver X Receptors, Orphan Nuclear Receptors, Osteosarcoma, Promoter Regions, Genetic, RNA Interference, RNA, Messenger, RNA, Small Interfering, Transcription, Genetic, Up-Regulation.
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Does liver X receptor α inhibit osteosarcoma cell proliferation through up-regulation of FoxO1? Context: Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. We analyzed liver X receptor α (LXRα) mRNA expression in 16 pairs of human osteosarcoma tissues and adjacent noncancerous tissues. Moreover, we investigated LXRα's potential role in regulating cell proliferation in Saos-2 and U2OS cells. We found that activation of LXRα, a member of nuclear receptor, was able to inhibit cell proliferation in Saos-2 and U2OS cells. At the molecular level, our results further revealed that expression of tumor suppressor gene, FoxO1, was up-regulated by LXRα activation. LXRα activates FoxO1 transcription through a direct binding on its promoter region.
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LXRα acts as a tumor suppressor for osteosarcoma, which may offer a new way in molecular targeting cancer treatment. Final Decision: yes