system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
All of the following are true about Methicillin resistance in MRSA, except-
assistant
The correct answer is  Resistance in MRSA is chromosomally mediated (not plasmid mediated). Resistance is produced as a result of altered PBP's- mediated chromosomal mec A gene which codes for altered PBP- 2A. Resistance may be produced by hyperproduction of beta-lactamase Methicillin resistance is expressed more at 30degC than at 37degC. Therefore, resistance may be missed at incubation temperature at 37degC during susceptibility testing.