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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
True about imipenem is -
assistant
The correct answer is  Ans. is 'c' i.e., It can be used with cilastatin o A limiting feature of imipenem is its rapid hydrolysis by the enzyme dehydropeptidase-I located on the brush border of renal tubular cells. Cilastatin is a reversible inhibitor of dehydropeptidase -1. It protects the imipenem from this enzyme. o Carbapenems have the widest spectrum of all currently available antimicrobials, being bactericidal against most gram positive andgram negative aerobic and anaerobic pathogenic bacteria.