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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Antiemetics, Double-Blind Method, Female, Granisetron, Humans, Middle Aged, Nausea, Postoperative Complications, Serotonin Antagonists, Vomiting.
user
Does granisetron reduce incidence of nausea and vomiting after breast surgery? Context: Postoperative nausea and vomiting (PONV) remains a troublesome problem. The study was performed to evaluate the antiemetic efficacy of prophylactic granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, on the incidence of PONV in patients undergoing general anaesthesia for breast surgery. In a randomized, placebo-controlled, double-blind study, 50 female patients, 45-68 years, were given a single dose of either placebo (saline, n = 25) or granisetron (40 micrograms.kg-1, n = 25) intravenously over 2-5 min immediately before the induction of anaesthesia. Postoperatively, during the first 24 hours after anaesthesia, the incidence of PONV and adverse events was recorded. The treatment groups were similar for patient demographics, types of surgery, anaesthetic and postoperative management. Postoperatively, the incidence of PONV was 48% and 16% after administration of placebo and granisetron, respectively (P < 0.05). No differences in the incidence of other adverse events were observed between the two groups.
assistant
Granisetron is an effective antiemetic for preventing PONV in patients undergoing general anaesthesia for breast surgery. Final Decision: yes