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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Administration, Oral, Aged, Aged, 80 and over, Alendronate, Arthroplasty, Replacement, Knee, Bone Density, Bone Density Conservation Agents, Bone Remodeling, Bone Resorption, Double-Blind Method, Female, Follow-Up Studies, Humans, Knee Prosthesis, Male, Middle Aged, Osteoarthritis, Knee, Prosthesis Failure, Radiography.
user
Does once-weekly oral medication with alendronate prevent migration of knee prostheses : A double-blind randomized RSA study? Context: Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years. There was no difference in migration of implants between the two groups.
assistant
With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period. Final Decision: no