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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Which diuretic acts without requiring access to renal tubular lumen
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The correct answer is  Mechanism of action of diuretics: Aldosterone antagonists: Aldosterone acts by combining with an intracellular mineralocoicoid receptor It induces the formation of aldosterone-induced proteins (AIP) . These AIPs promote Na+ reabsorption and K+ secretion Spironolactone is an aldosterone antagonist It acts from the interstitial side of the tubular cell It combines with Mineralocoicoid Receptor and inhibits the formation of AIPs