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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Aged, Amyloid, Aniline Compounds, Apolipoproteins E, Body Mass Index, Brain, Female, Humans, Hyperglycemia, Imaging, Three-Dimensional, Insulin Resistance, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Positron-Emission Tomography, Predictive Value of Tests, Thiazoles.
user
Does insulin resistance predict brain amyloid deposition in late middle-aged adults? Context: Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. No studies have examined if IR is associated with an in vivo index of amyloid in the human brain in late middle-aged participants at risk for AD. Asymptomatic, late middle-aged adults (N = 186) from the Wisconsin Registry for Alzheimer's Prevention underwent [C-11]Pittsburgh compound B (PiB) positron emission tomography. The cross-sectional design tested the interaction between insulin resistance and glycemic status on PiB distribution volume ratio in three regions of interest (frontal, parietal, and temporal). In participants with normoglycemia but not hyperglycemia, higher insulin resistance corresponded to higher PiB uptake in frontal and temporal areas, reflecting increased amyloid deposition.
assistant
This is the first human study to demonstrate that insulin resistance may contribute to amyloid deposition in brain regions affected by AD. Final Decision: yes