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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Antibodies, Bacterial, Antigens, Bacterial, Bacterial Proteins, Cell Line, Chromatography, Liquid, Enzyme-Linked Immunosorbent Assay, Female, Helicobacter pylori, Humans, Immunoglobulin E, Immunoglobulin G, Male, Mass Spectrometry, Mast Cells, Middle Aged, Molecular Weight, Sequence Analysis, DNA, Serum, Urticaria, Young Adult.
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Does a 21-35 kDa Mixed Protein Component from Helicobacter pylori activate Mast Cells Effectively in Chronic Spontaneous Urticaria? Context: Helicobacter pylori (H. pylori) seem to involve in the etiology of chronic spontaneous urticaria (CSU). But studies of the pathogenic mechanism are very little. In this study, we detected the serum-specific anti-H. pylori IgG and IgE antibodies in 211 CSU and 137 normal subjects by enzyme-linked immunosorbent assay (ELISA), evaluated the direct activation effects of H. pylori preparations and its protein components on human LAD In CSU patients, the positive rate of anti-H. pylori IgG positive rate was significantly higher than that in normal controls, and the anti-H. pylori IgE levels had no statistical difference between H. pylori-infected patients with and without CSU. Further studies suggested that H. pylori preparations can directly activate human LAD
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A 21-35 kDa mixed protein component should be regarded as the most promising pathogenic factor contributing to the CSU associated with H. pylori infection. Final Decision: yes