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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Cell Membrane, Hydrogen, Interleukin-1beta, Intestines, Lipid Peroxidation, Lung Injury, Male, NF-kappa B, Neutrophils, Rats, Rats, Sprague-Dawley, Reperfusion Injury, Sodium Chloride, Tumor Necrosis Factor-alpha.
user
Does hydrogen-rich saline reduce lung injury induced by intestinal ischemia/reperfusion in rats? Context: Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats. Male Sprague-Dawley rats (n=30, 200-220g) were divided randomly into three experimental groups: sham operated, intestinal I/R plus saline treatment (5ml/kg, i.v.), and intestinal I/R plus hydrogen-rich saline treatment (5ml/kg, i.v.) groups. Intestinal I/R was produced by 90min of intestinal ischemia followed by a 4h of reperfusion. Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat.
assistant
Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. Final Decision: yes