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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Anorexia Nervosa, Antigens, CD, Body Mass Index, Dissociative Disorders, Female, Humans, Lymphocyte Count, Lymphocyte Subsets, Malnutrition, Zinc.
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Does malnutrition induce dissociated changes in lymphocyte count and subset proportion in patients with anorexia nervosa? Context: The effect of nutritional state on lymphocytes in patients with anorexia nervosa (AN) was studied. We studied total lymphocyte count (TLC), lymphocyte subsets, and nutritional markers [body mass index (BMI), insulin-like growth factor-1 (IGF-I)], and serum zinc concentration) in 33 patients with AN and 10 healthy controls. TLC positively correlated with BMI (r = .680, p < .001), IGF-I (r = .609 p < .001), and zinc (r = .589, p < .001). The CD4+ T-lymphocyte (CD4) proportion correlated negatively with BMI (r = -.301, p = .05) and IGF-I (r = -.346, p = .023), counteracting the effect of malnutrition on TLC. However, because this increase in CD4 proportion was weak, patients with very severe malnutrition (indicated by serum zinc less than 40 microg/dL) had critically low CD4 counts of less than 200 cells/microL.
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Our findings suggest that lymphocyte counts and subset proportion change in an opposite manner in patients with AN, and that decrease in serum zinc levels is nutrition-related. Final Decision: yes