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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 52-year-old man comes to to the emergency department with fatigue and shortness of breath that has become progressively worse over the past week. He had an upper respiratory tract infection 2 weeks ago, for which he was given an antibiotic. He has hypertension, type 2 diabetes mellitus, and colonic polyps diagnosed on screening colonoscopy 2 years ago. His mother has systemic lupus erythematosus and his brother has a bicuspid aortic valve. He does not smoke cigarettes or drink alcohol. Current medications include lisinopril and metformin. His temperature is 37.3°C (99.1°F), pulse is 91/min, respirations are 18/min, and blood pressure is 145/84 mm Hg. His conjunctivae are pale. Cardiac examination shows a late systolic crescendo-decrescendo murmur at the right upper sternal border. Laboratory studies show:
Leukocyte Count 9,500/mm3
Hematocrit 24%
Platelet Count 178,000/mm3
LDH 215 U/L
Haptoglobin 22 mg/dL (N=41–165 mg/dL)
Serum
Na+ 140 mEq/L
K+ 4.6 mEq/L
CL- 100 mEq/L
HCO3- 25 mEq/L
Urea nitrogen 21 mg/dL
Creatinine 1.2 mg/dL
Total bilirubin 1.9 mg/dL
A peripheral blood smear is shown. Which of the following is the most likely cause of this patient's anemia?"
assistant
Mechanical destruction of erythrocytes