system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adenocarcinoma, Adenocarcinoma, Mucinous, Biomarkers, Tumor, Cell Differentiation, Chi-Square Distribution, Colorectal Neoplasms, Female, Humans, Immunohistochemistry, Lymphocyte Count, Lymphocytes, Tumor-Infiltrating, Male, Neoplasm Staging, Probability, Sensitivity and Specificity.
user
Is mucinous differentiation in colonic adenocarcinoma associated with a reduction in tumour-infiltrating lymphocytes? Context: The aim of this study was to examine the density of tumour-infiltrating lymphocytes (TILs) in colorectal carcinomas showing mucinous differentiation. We examined 33 adenocarcinomas showing variable mucinous differentiation and compared the density of TILs with that of 65 adenocarcinomas of no special type (NOS) showing no mucinous differentiation. Mucinous differentiation is associated with a significantly lower density of TILs compared to adenocarcinoma NOS (P=0.0016; chi-squared test with continuity correction). This reduction in TILs is present also in adjacent foci of adenocarcinoma NOS within mucinous tumours.
assistant
There is a reduction in the number of TILs in all areas of colorectal adenocarcinomas that show mucinous differentiation, which may help explain the increased biological aggressiveness associated with this pattern of differentiation. Final Decision: yes