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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Breast Neoplasms, Disease-Free Survival, Female, Humans, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Obesity, Morbid, Retrospective Studies.
user
Does morbid obesity disadvantage patients with in situ or early-stage carcinoma undergoing breast-conserving surgery? Context: To determine whether morbidly obese (MO) patients with early-stage breast cancer (BCa) benefit from standard-of-care interventions. Between 1992 and 2005, 100 patients underwent breast-conserving surgery and postoperative whole-breast irradiation of 50 Gy for minimally invasive BCa with tumor-free surgical margins. Twenty-seven MO women were compared to 73 non-morbidly obese (NMO) patients. At 10 years, the cumulative disease-free survival rate for the NMO patients was 91% compared to the non-statistically significant lower rate of 89% in the MO women (p=0.66). Patients who were excessively obese were not at an increased risk for local (p=0.99) or regional disease recurrence (p=0.29).
assistant
The results suggest that patients with minimally invasive BCa and excessively large body habitus should not be disqualified from receiving breast-conserving therapy. Final Decision: no