system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A palpable mass is noted in the right lobe of the thyroid of a 45-year-old man who visits his physician for a periodic checkup. A biopsy is performed and results in a diagnosis of medullary carcinoma of the thyroid. Which of the following histologic features of thyroid disease would most likely be present in this biopsy specimen?
assistant
The correct answer is  - Medullary carcinoma of thyroid is a calcitonin-producing tumor of C cells of thyroid contributing to amyloid deposition within tumor. OTHER OPTIONS GIVEN: - Tumor cells with "Orphan Annie" nuclei & presence of psammoma bodies are seen in papillary carcinoma of thyroid. - Infiltrates of lymphocytes with germinal center formation are seen in Hashimoto thyroiditis.