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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Carbon Tetrachloride, Carcinoma, Hepatocellular, Cartilage Oligomeric Matrix Protein, Hepatic Stellate Cells, Liver, Liver Cirrhosis, Liver Neoplasms, Mice.
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Does cartilage oligomeric matrix protein participate in the pathogenesis of liver fibrosis? Context: Liver fibrosis is characterized by significant accumulation of extracellular matrix (ECM) proteins, mainly fibrillar collagen-I, as a result of persistent liver injury. Cartilage oligomeric matrix protein (COMP) is largely found in the ECM of skeletal tissue. Increased COMP expression has been associated with fibrogenesis in systemic sclerosis, lung fibrosis, chronic pancreatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that COMP could induce fibrillar collagen-I deposition and participate in matrix remodeling thus contributing to the pathophysiology of liver fibrosis. Thioacetamide (TAA) and carbon tetrachloride (CCl COMP expression was detected in livers from control WT mice and was upregulated in response to either TAA or CCl
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These results suggest that COMP contributes to liver fibrosis by regulating collagen-I deposition. Final Decision: yes