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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, METHODS, METHODS, METHODS, METHODS, RESULTS. Meshes: Adult, Body Mass Index, Crown-Rump Length, Energy Intake, Female, Fetal Development, Humans, Maternal Nutritional Physiological Phenomena, Preconception Care, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Prospective Studies.
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Is a periconceptional energy-rich dietary pattern associated with early fetal growth : the Generation R study? Context: To identify periconceptional maternal dietary patterns associated with crown-rump length (CRL), estimated fetal weight (EFW) and birthweight. Population-based prospective birth cohort study. Rotterdam, the Netherlands. For this study, 847 pregnant Dutch women were eligible. Women were included between 2001 and 2005. Information on nutritional intake was collected by a semiquantitative food frequency questionnaire. For extracting dietary patterns, principal component factor analysis was used. Fetal growth was assessed using ultrasound measurements. Information on birth outcomes was retrieved from medical records. Multivariate regression analyses were used. Crown-to-rump length, estimated fetal weight in second and third trimester and birthweight. An 'energy-rich dietary pattern' was identified, characterised by high intakes of bread, margarine and nuts. A significant association was shown between a high adherence to this dietary pattern (difference, mm: 2.15, 95% confidence interval 0.79-3.50) and CRL (linear trend analyses P = 0.015). No association was revealed between increasing adherence to this dietary pattern and EFW in second or third trimester, or birthweight.
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This study suggests that increasing adherence to an energy-rich dietary pattern is associated with increased CRL in the first trimester. Final Decision: yes