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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Enzyme-Linked Immunosorbent Assay, Female, Glial Fibrillary Acidic Protein, Humans, Male, Myelin Basic Protein, Nerve Growth Factors, Neuroglia, Neurons, Phosphopyruvate Hydratase, S100 Calcium Binding Protein beta Subunit, S100 Proteins, Schizophrenia.
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Are increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia related to a degenerative release of glial fibrillar acidic protein , myelin basic protein and neurone-specific enolase from glia or neurones? Context: To assess levels of glial fibrillar acidic protein (GFAP), myelin basic protein (MBP), neurone-specific enolase (NSE) and S100B in patients with first-onset schizophrenia. We investigated CSF and serum samples from 12 patients with first-onset schizophrenia and from 17 control subjects by ELISA (GFAP, MBP) or immunoluminometric sandwich assays (NSE, S100B). Patients with schizophrenia had significantly higher levels of S100B in CSF (p = 0.004; 2.73 (SD 0.80) v 1.92 (0.58) microg/l) and serum (p = 0.032; 0.09 (0.03) v 0.08 (0.02) microg/l) in comparison with those in the matched control group. No diagnosis-dependent differences of protein concentration were seen for GFAP, MBP and NSE.
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Our finding of increased levels of S100B in patients with schizophrenia without an indication for significant glial (GFAP, MBP) or neuronal (NSE) damage may be interpreted as indirect evidence for increased active secretion of S100B during acute psychosis. Final Decision: no