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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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True about wilson\'s disease –
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The correct answer is  Diagnosis of Wilson disease 
Diagnosis includes the demonstration of a reduced ceruloplasmin level, increased urinary excretion of copper, the presence of Kayser-Fleischer rings in the cornea of the eyes, and an elevated hepatic copper level, in the appropriate clinical setting.

Ceruloplasmin


Serum glycoprotein that contains six copper atoms.
Copper incorporation into ceruloplasmin is impared in Wilson's disease.
95% of homozygotes have levels < 20mg/dL (rarely are levels > 30 mg/dL).
May also be low in other hypoproteinemic states
May be low in 20% of asymptomatic heterozygotes


Serum free copper (unbound copper)


Greater than 25 mg in symptomatic pts (normal < 10)


Slit lamp detection of Kayser Fleischer Rings
24 hour urinary copper excretion


May exceed 100 mg/24 h-use metal free container
False + with sign. Proteinuria (ceruloplasmin loss)


Liver biopsy


> 250 g/g copper dry weight in homozygotes (normal < 50).
Cholestatic diseases (PBC/PSC) may have elevated hepatic copper dry weight.