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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Insulin causes lipogenesis by all except:
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The correct answer is  Inhibits pyruvate dehydrogenase Role of insulin in lipogenesis: Insulin promotes lipogenesis by increasing activity of acetyl-CoA carboxylase activity, the principal enzyme of lipogenesis Insulin promotes the entry of glucose in some tissues such as skeletal muscle and adipocytes and thus increases the availability of pyruvate for fatty acid synthesis and glycerol 3-phosphate for esterification of the newly formed fatty acids. [Note that glucose transpo in some cells of body are insulin-independent - hepatocytes, RBCs, cells of nerveous system, corneal Insulin also activates pyruvate dehydrogenase (only in adipose tissue, not in liver) which catalyzes pyruvate into Acetyl-CoA the building blocks of fatty acids. Insulin decreases intracellular cAMP and thus inhibits lipolysis in adipose tissue. This reduces the concentration of plasma free fatty acids and long chain acyl-CoA (an inhibitor of lipogenesis).