system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Tubocurare affects which muscle first?
assistant
The correct answer is  Sequence of blockade : face - jaw- pharynx - larynx - respiratory (including diaphragm) - trunk muscle - limb muscle. Face muscles are involved earliest. 1)in non-depolarising blocker (d-Tc), earliest clinical sign is Ptosis and diploia 2)In succinylcholine (depolarising blocker ),First clinical sign is Fasciculation of eye lids.