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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Angioplasty, Balloon, Coronary, Asia, Southeastern, Cardiovascular Diseases, Cohort Studies, Complement System Proteins, Coronary Artery Bypass, Death, Sudden, Cardiac, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genotype, Humans, Incidence, Kaplan-Meier Estimate, Longitudinal Studies, Male, Mannose-Binding Lectin, Middle Aged, Myocardial Infarction, Prospective Studies.
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Is low Mannose-Binding Lectin ( MBL ) genotype associated with future cardiovascular events in type 2 diabetic South Asians . A prospective cohort study? Context: South Asians have a high burden of type 2 diabetes and vascular complications. Vascular inflammation is considered central in the pathophysiology of atherosclerosis, and the complement system is thought to play an important role. Mannose-Binding Lectin (MBL), which activates the lectin pathway of complement activation, has been introduced as a risk marker of vascular damage. The present study explores the association of MBL levels, genotype and cardiovascular events in type 2 diabetic South Asians. We conducted a prospective observational study. A cohort consisting of 168 type 2 diabetic South Asians was followed for a median duration of 7.66 years. At baseline, MBL levels and genotype were determined. The association with future cardiovascular events was assessed by Cox proportional hazard regression. During follow-up, 31 cardiovascular events occurred in 22 subjects (11 men, 11 women). The O/O genotype was significantly associated with the occurrence of cardiovascular events (hazard ratio 3.42, 95%CI 1.24-9.49, P = 0.018). However, log MBL levels were not associated with the occurrence of cardiovascular events (hazard ratio 0.93, 95% CI 0.50-1.73).
assistant
In type 2 diabetic South Asians, the O/O MBL genotype is associated with cardiovascular events, although single serum MBL levels are not. Final Decision: yes