system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Class I Phosphatidylinositol 3-Kinases, Comparative Genomic Hybridization, DNA Mutational Analysis, Female, Gene Dosage, Humans, Male, Meningeal Neoplasms, Meningioma, Middle Aged, Mutation, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Smoothened Receptor, Young Adult.
user
Are oncogenic PI3K mutations as common as AKT1 and SMO mutations in meningioma? Context: Meningiomas are the most common primary intracranial tumor in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the possibility of targeted therapies for some patients. The frequency of such mutations in clinical cohorts and the presence of other actionable mutations in meningiomas are important to define. We used high-resolution array-comparative genomic hybridization to prospectively characterize copy-number changes in 150 meningiomas and then characterized these samples for mutations in AKT1, KLF4, NF2, PIK3CA, SMO, and TRAF7. Similar to prior reports, we identified AKT1 and SMO mutations in a subset of non-NF2-mutant meningiomas (ie, ∼9% and ∼6%, respectively). Notably, we detected oncogenic mutations in PIK3CA in ∼7% of non-NF2-mutant meningiomas. AKT1, SMO, and PIK3CA mutations were mutually exclusive. AKT1, KLF4, and PIK3CA mutations often co-occurred with mutations in TRAF7. PIK3CA-mutant meningiomas showed limited chromosomal instability and were enriched in the skull base.
assistant
This work identifies PI3K signaling as an important target for precision medicine trials in meningioma patients. Final Decision: yes