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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
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Cyclosporin-A acts on:
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The correct answer is  Cyclosporine binds to intracellular cyclophilin, and this complex interacts with calcineurin. Calcineurin is crucial for normal lymphokine gene activation, and its inhibition by cyclosporine consequently interferes with the production of interleukins-2, -3, and -4 (IL-2, IL-3, and IL-4), tumor necrosis factor-alpha (TNF-), and other impoant mediators of inflammation. In turn, specific and potent inhibition of T-cell activation (especially CD4 cells) is achieved. Adverse effects: The most frequently encountered problem with cyclosporine is nephrotoxicity, and in many patients cyclosporine causes a rise in serum creatinine level and a reduction of glomerular filtration rate (GFR). Ref: Scales D.C., Granton J.T. (2005). Chapter 90. The Transplant Patient. In J.B. Hall, G.A. Schmidt, L.D. Wood (Eds), Principles of Critical Care, 3e.