system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 52-year-old postmenopausal woman seeks evaluation at a medical clinic with complaints of back pain and increased fatigue for 6 months. For the past week, the back pain has radiated to her legs and is stabbing in nature (7/10 in intensity). There are no associated paresthesias. She unintentionally lost 4.5 kg (10.0 lb) in the past 6 months. There is no history of trauma to the back. The past medical history is insignificant and she does not take any medications. The physical examination is normal. The laboratory results are as follows:
Hemoglobin 10 g/dL
Hematocrit 30%
Mean corpuscular volume 80 fL
Serum creatinine 1.5 mg/dL
Serum total protein 9 g/dL
Serum albumin 4.2 g/dL
Serum calcium 11.2 mg/dL
A peripheral blood smear shows normocytic normochromic cells. An X-ray reveals multiple osteolytic lesions in the vertebrae and long bones. Serum protein electrophoresis shows a monoclonal spike. A bone marrow biopsy shows increased plasma cells making up greater than 50% of the total cell population. Which of the following is the most likely diagnosis in this patient?
assistant
Multiple myeloma