system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Skin pigmentation & Icthyosis like side effects are seen in
assistant
The correct answer is  Ichthyosis - Fish like scaling (d/t severe dryness in patient) - Causing skin to break Two types - Congenital Acquired I.vulgaris - Autosomal Dominant, MC type Deficiency - Filaggrin Involves Extensors Leprosy - Involvement of ANS No sweating - dry skin X linked ichthyosis - X-linked Recessive defect with steroid sulphatase Extensor + Flexors involvement Clofazimine - Causes darkening and dryness of skin Lamellar ichthyosis - Autosomal Recessive Defect with Transglutaminase Whole body involvement When infant born is covered with Membrane called collodion membrane then baby k/a collodion baby. Most severe type Ichthyosis - Harlequin ichthyosis - Autosomal Recessive- Due to ABCA-12 gene defect