system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND. Meshes: Adult, Cross-Over Studies, Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 CYP3A, Drug Interactions, Female, Humans, Itraconazole, Male, Oxycodone, Paroxetine, Young Adult.
user
Is exposure to oral oxycodone increased by concomitant inhibition of CYP2D6 and 3A4 pathways , but not by inhibition of CYP2D6 alone? Context: Oxycodone is an opioid analgesic that is metabolized mainly in the liver by cytochrome P450 (CYP) 2D6 and 3A4 enzymes. So far, the effects of CYP2D6 or CYP3A4 inhibitors on the pharmacokinetics of oxycodone in humans have not been systematically studied.
assistant
Drug interactions arising from CYP2D6 inhibition most likely have minor clinical importance for oral oxycodone. When both of CYP2D6 and CYP3A4 pathways are inhibited, the exposure to oral oxycodone is increased substantially. Final Decision: yes