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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Which of the following immunosuppressant drugs is most nephrotoxic?
assistant
The correct answer is  Among the given drugs Tacrolimus has dose-limiting nephrotoxicity In addition, it can precipitate diabetes, alopecia, and diarrhea. Hypeension, hirsutism, gum hyperplasia is less marked compared to cyclosporin. Other drugs listed above are antiproliferative drugs. These have no excess nephrotoxicity effect. they act mainly by preventing the clonal expansion of T and B Lymphocytes. ESSENTIALS OF MEDICAL PHARMACOLOGY SEVENTH EDITION -K.D TRIPATHI Page:881,882 ,883