system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 32-year-old woman presents to the office with complaints of frothy urine and swelling in her body that started 6 days ago. She says that she first noticed the swelling in her face that gradually involved other parts of her body. On further questioning, she gives a history of rheumatoid arthritis for 2 years. She is taking Penicillamine and Methotrexate for the past 6 months. Vitals include: blood pressure 122/89 mm Hg, pulse rate 55/min, temperature 36.7°C (98.0°F), and a respiratory rate 14/min. On examination, there is generalized pitting edema along with some subcutaneous nodules on the dorsal aspect of the forearm.
Urinalysis
pH 6.6
Color light yellow
RBC none
WBC 1–2/HPF
Protein 4+
Cast fat globules
Glucose absent
Crystal none
Ketone absent
Nitrite absent
24 hours urine protein excretion  4.8 g
    Basic metabolic panel
Sodium 141 mEq/L
Potassium 5.1 mEq/L
Chloride 101 mEq/L
Bicarbonate 22 mEq/L
Albumin 3.2 mg/dL
Urea nitrogen 17 mg/dL
Creatinine 1.3 mg/dL
Uric Acid 6.8 mg/ dL
Calcium 8.9 mg/ dL
Glucose 111 mg/dL
A renal biopsy is ordered which shows diffuse capillary and glomerular basement membrane thickening. Which of the following is the most likely cause for her impaired renal function?
assistant
Membranous nephropathy