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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, METHODS, METHODS, RESULTS. Meshes: Absorptiometry, Photon, Adult, Aged, Asian Continental Ancestry Group, Blood Glucose, Body Mass Index, Bone Density, Carbon, Carboxylic Acids, Coronary Vessels, Cross-Sectional Studies, Female, Humans, Insulin, Lipids, Logistic Models, Male, Middle Aged, Multivariate Analysis, Osteocalcin, Republic of Korea, Risk Factors, Sex Factors, Tomography, X-Ray Computed, Vascular Calcification.
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Is coronary artery calcification associated with high serum concentration of undercarboxylated osteocalcin in asymptomatic Korean men? Context: Osteocalcin is associated with energy metabolism and atherosclerosis, besides bone metabolism. However, the association between osteocalcin or its undercarboxylated form (ucOC) and coronary artery calcification is controversial. To evaluate the relationship between coronary artery calcium score (CACS) and the concentration of serum osteocalcin and ucOC. Cross-sectional. A total of 162 subjects (114 men and 48 women) with no angina symptom. Serum analyses included glucose, insulin and lipid profiles as well as osteocalcin and ucOC. Bone mineral density (BMD) was measured by dual X-ray absorptiometry. CACS was measured using multidetector computed tomography and categorized into CACS = 0 and CACS > 0. The mean osteocalcin concentration in men was 15·6 ± 4·2 for CACS = 0 group and 14·1 ± 4·0 for CACS > 0 group, respectively (P = 0·050). In women, the osteocalcin concentration, ucOC concentration and ucOC to osteocalcin ratio (OCR) were not different between the CACS groups. However, the concentrations of osteocalcin and ucOC were significantly lower in women with hypertension or diabetes than those without, respectively. In the multivariate logistic regression models adjusted for medical history, body mass index, lipid profiles, insulin resistance and BMD in men, the higher concentration of ucOC and higher OCR showed significant association with coronary calcification (CACS > 0).
assistant
Higher ucOC concentration was associated with coronary artery calcification independent of conventional cardiovascular risk factors and BMD in men. Final Decision: yes