system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A patient was started on fluphenazine. After few weeks of treatment, he started developing tremors, rigidity, bradykinesia and excessive salivation. First line of management for this patient is
assistant
The correct answer is  * Fluphenazine - D2 blocker (Anti-psychotic)* This is a case of typical antipsychotic induced parkinsonism.* The only group of drugs effective against "Pharmacological parkinsonism" (Drug induced parkinsonism) are Anti-cholinergic agents* Trihexyphenidyl:# Has high Central: Peripheral anticholinergic actions than atropine# Acts by reducing unbalanced cholinergic activity in striatum of parkinsonism patients# Order of relief of symptoms: Tremors > Rigidity > Hypokinesia# Peripheral actions - responsible for treatment of sialorrhea# Started at low dose and gradually increased