system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Catheter-Related Infections, Catheterization, Central Venous, Catheterization, Peripheral, Clinical Competence, Female, Guideline Adherence, Humans, Infant, Extremely Premature, Infant, Newborn, Intensive Care, Neonatal, Male, Pregnancy, Retrospective Studies, Risk Assessment, Sepsis, Umbilical Veins.
user
Is incorrect umbilical vein catheterization associated with severe periventricular hemorrhages and mortality in extremely premature newborns? Context: To investigate the relationship between umbilical vein catheter (UVC) placement and death in extremely premature newborns (<29 weeks gestation). Utilizing a retrospective, case-control study design, results for newborns that received UVC placements and died were compared with those who received UVC placements and survived (n = 719) by univariate and multiple logistic regression analyses. Death rate was 30% in infants with low lines versus 16% in those without (p = 0.012). High UVC tip placement significantly and independently increased severe periventricular hemorrhages (p = 0.014). Severe periventricular hemorrhage increased death rates by 3-fold independent of gestational age (p <  0.001). Proper line placement significantly reduced severe periventricular hemorrhage by 2.5-fold independent of gestational age (p = 0.019).
assistant
In extremely premature newborns, incorrect UVC placement is significantly associated with death through its relation to severe periventricular hemorrhage. Final Decision: yes