system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Child, Female, Follow-Up Studies, Gingival Crevicular Fluid, Humans, Male, Neutrophil Infiltration, Neutrophils, Orthodontic Wires, Periodontal Ligament, Peroxidase, Saliva, Stress, Mechanical, Tooth Movement Techniques.
user
Is myeloperoxidase activity increased in gingival crevicular fluid and whole saliva after fixed orthodontic appliance activation? Context: Orthodontic tooth movement uses mechanical forces that result in inflammation in the first days. Myeloperoxidase (MPO) is an enzyme found in polymorphonuclear neutrophil (PMN) granules, and it is used to estimate the number of PMN granules in tissues. So far, MPO has not been used to study the inflammatory alterations after the application of orthodontic tooth movement forces. The aim of this study was to determine MPO activity in the gingival crevicular fluid (GCF) and saliva (whole stimulated saliva) of orthodontic patients at different time points after fixed appliance activation. MPO was determined in the GCF and collected by means of periopaper from the saliva of 14 patients with orthodontic fixed appliances. GCF and saliva samples were collected at baseline, 2 hours, and 7 and 14 days after application of the orthodontic force. Mean MPO activity was increased in both the GCF and saliva of orthodontic patients at 2 hours after appliance activation (P <0.02 for all comparisons). At 2 hours, PMN infiltration into the periodontal ligament from the orthodontic force probably results in the increased MPO level observed at this time point.
assistant
MPO might be a good marker to assess inflammation in orthodontic movement; it deserves further studies in orthodontic therapy. Final Decision: yes