system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adult, Aged, Aged, 80 and over, Automation, Laboratory, Cell Nucleus, Cell Proliferation, Disease Progression, Female, Humans, Ki-67 Antigen, Lymph Nodes, Lymphoma, Follicular, Male, Middle Aged, Neoplasm Grading, Prognosis, Reproducibility of Results, Software.
user
Does software-automated counting of Ki-67 proliferation index correlate with pathologic grade and disease progression of follicular lymphomas? Context: To examine the accuracy of software-assisted measurement of the Ki-67 proliferation index (PI) and its correlation with the grade and clinical progression of follicular lymphoma (FL). High-power field equivalents were extracted from H&E- and Ki-67-immunostained slides of FL, and a nuclear quantitation algorithm was used to calculate a PI. Representative fields were manually counted for validation with close agreement. The PI was significantly higher in World Health Organization grade 3 FL than grade 1 to 2 FL. Disease progression, as defined by subsequent treatment with radiation or cytotoxic chemotherapy, was also significantly associated with elevated PI but not pathologic grade.
assistant
These data show that software-automated quantitation of Ki-67 can provide both a useful adjunct to pathologic grade in FL and improved prognostic information for patients. Final Decision: yes