system
Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Adolescent, Adult, Aged, Area Under Curve, Biological Availability, Detergents, Double-Blind Method, Female, Hepatitis A Antibodies, Hepatitis Antibodies, Hepatitis B Antibodies, Humans, Immunization, Passive, Immunoglobulins, Intravenous, Injections, Intramuscular, Male, Middle Aged, Organophosphates, Safety, Solvents.
user
Does solvent/detergent treatment alter the tolerance or uptake of human normal immunoglobulin for intramuscular injection? Context: The tolerability and pharmacokinetics of a solvent/detergent-treated intramuscular immunoglobulin were compared with those of the standard product. Single, 750-mg intramuscular (i.m.) injections were administered to a total of 36 healthy individuals: 23 in a double-blind trial and 13 in an open trial. Changes in specific serum hepatitis A and hepatitis B antibodies were monitored for a period of up to 3 months postinjection. No serious adverse reactions were reported, and the bioavailability of the solvent/detergent-treated preparation was equivalent to that of the standard i.m. immunoglobulin.
assistant
There is no evidence that solvent/detergent treatment alters the pharmacokinetics or tolerance of human normal immunoglobulin, but it offers additional assurance against potential virus transmission. Final Decision: no