system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 68-year-old woman comes to the physician because of lower back pain that began suddenly 2 weeks ago after getting up from her chair. She has hypertension, chronic bilateral knee pain, and a history of breast cancer 15 years ago that was treated with lumpectomy. Her mother has rheumatoid arthritis. Medications include hydrochlorothiazide and acetaminophen. She appears well. Her vital signs are within normal limits. Physical examination shows tenderness to palpation of the lower spine. Both knees are enlarged and swollen. Neurologic examination shows sensorineural hearing impairment of the left ear. Her gamma-glutamyl transferase (GGT) is 30 U/L (N: 0–30 U/L), alkaline phosphatase (ALP) is 310 U/L, and serum calcium is 10.2 mg/dL. A spinal x-ray shows a fracture in the L4 vertebra. Which of the following is the most likely diagnosis?
assistant
Paget disease of bone