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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Animals, Cell Adhesion Molecules, Diphosphonates, Echocardiography, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Myocardial Infarction, Myocardium, Pamidronate, Rats, Rats, Wistar, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Tissue Inhibitor of Metalloproteinase-1, Ventricular Remodeling.
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Does pamidronate attenuate diastolic dysfunction induced by myocardial infarction associated with changes in geometric patterning? Context: The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months. Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins.
assistant
Pamidronate attenuates diastolic dysfunction following MI. Final Decision: yes