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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Analysis of Variance, Animals, Ankle, Body Weight, Disease Models, Animal, Isometric Contraction, Male, Microscopy, Electron, Muscle, Skeletal, Myelin Sheath, Nerve Fibers, Neural Conduction, Organ Size, Rats, Rats, Wistar, Reaction Time, Sciatic Neuropathy, Torque.
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Do repeated bouts of fast eccentric contraction produce sciatic nerve damage in rats? Context: We evaluated sciatic nerve impairment after eccentric contractions (ECs) in rat triceps surae. Wistar rats were randomly assigned to different joint angular velocity: 180°/s (FAST), 30°/s (SLOW), or nontreated control (CNT). FAST and SLOW groups were subjected to multiple (1-4) bouts of 20 (5 reps, 4 sets) ECs. Nerve conduction velocity (NCV) and isometric tetanic ankle torque were measured 24 h after each ECs bout. We also assessed nerve morphology. After 4 ECs bouts, NCVs and isometric torque in the FAST group were significantly lower than those in the CNT (NCV: 42%, torque: 66%; P < 0.05). After 4 bouts, average nerve diameter was significantly smaller in the FAST group [2.39 ± 0.20 μm vs. 2.69 ± 0.20 μm (CNT) and 2.93 ± 0.24 μm (SLOW); P < 0.05] than that in other two groups.
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Chronic ECs with high angular velocity induce serious nerve damage. Muscle Nerve 54: 936-942, 2016. Final Decision: yes