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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, METHODS, RESULTS. Meshes: Acute Lung Injury, Adjuvants, Anesthesia, Anesthesia, Intravenous, Animals, Bronchoalveolar Lavage Fluid, Chemokine CXCL2, Edetic Acid, Interleukin-6, Ketamine, Lipopolysaccharides, Midazolam, Propofol, Pulmonary Gas Exchange, Random Allocation, Rats, Rats, Sprague-Dawley, Respiration, Artificial, Respiratory Distress Syndrome, Adult, Sulfites, Systemic Inflammatory Response Syndrome, Tumor Necrosis Factor-alpha.
user
Do additives in intravenous anesthesia modulate pulmonary inflammation in a model of LPS-induced respiratory distress? Context: It has been suggested that propofol with ethylenediaminetetraacetic acid (EDTA) can modulate the systemic inflammatory response. Prolonged higher levels of pulmonary inflammation are associated with poor outcome of patients with acute lung injury. In the present study, we hypothesized that pulmonary inflammation could be modulated by propofol with EDTA compared with propofol with sulfite. Respiratory distress was induced in rats (n=25) by intratracheal nebulization of lipopolysaccharide (LPS). After 24 h, animals were randomized to either propofol with EDTA (Propofol(EDTA)), propofol with sulfite (Propofol(sulfite)) or ketamine/midazolam (Ket/Mid); control animals received saline (n=30). Animals were ventilated for 4 h and blood gases were measured hourly. Bronchoalveolar lavage (BAL) was performed for cytokine analysis of: tumor necrosis factor (TNF), interleukin (IL)-6 and macrophage inflammatory protein (MIP)-2. LPS led to increased pulmonary inflammation in all groups compared with the control groups. Gas exchange deteriorated over time only in the LPS Propofol(sulfite) group and was significantly lower than the Ket/Mid group. Only IL-6 was significantly higher in the LPS Propofol(sulfite) group compared with both the Ket/Mid group and the Propofol(EDTA) group.
assistant
Pulmonary IL-6 can be modulated by additives in systemic anesthesia. Final Decision: yes