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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, RESULTS. Meshes: Angiotensin II, Animals, Blood Pressure, Echocardiography, Female, Heart Ventricles, Hypertrophy, Left Ventricular, Male, Myocardium, Peptidyl-Dipeptidase A, Potassium, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Rats, Wistar, Renin-Angiotensin System, Sodium, Sodium Chloride, Dietary.
user
Does salt intake during pregnancy alter offspring 's myocardial structure? Context: To evaluate the effects of low or high salt intake during pregnancy on left ventricle of adult male offspring. Low- (LS, 0.15%), normal- (NS, 1.3%) or high-salt (HS, 8% NaCl) diet was given to Wistar rats during pregnancy. During lactation all dams received NS as well as the offspring after weaning. To evaluate cardiac response to salt overload, 50% of each offspring group was fed a high-salt (hs, 4% NaCl) diet from the 21st to the 36th week of age (LShs, NShs, HShs). The remaining 50% was maintained on NS (LSns, NSns and HSns). Echocardiography was done at 20 and 30 weeks of age. Mean blood pressure (MBP), histology and left ventricular angiotensin II content (AII) were analyzed at 36 weeks of age. Interventricular septum, left ventricular posterior wall and relative wall thickness increased from the 20th to the 30th week of age only in HShs, cardiomyocyte mean volume was higher in HShs compared to NShs, LShs and HSns. AII and left ventricular fibrosis were not different among groups.
assistant
HS during pregnancy programs adult male offspring to a blood pressure and angiotensin II independent concentric left ventricular hypertrophy, with no fibrosis, in response to a chronic high-salt intake. Final Decision: yes