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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Aged, 80 and over, Cohort Studies, Exercise, Female, Follow-Up Studies, Humans, Hyperuricemia, Italy, Longitudinal Studies, Male, Muscle Strength, Predictive Value of Tests, Psychomotor Performance.
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Is hyperuricemia a significant predictor of poor physical performance in the elderly : THE Pro.V.A . Study? Context: Hyperuricemia (HU) is frequent in older people and associated with several medical conditions. The relationship between HU and physical performance is limited. We aimed to investigate the association between HU and physical performance over a 4.4 year follow-up in the elderly. 1,904 community-dwelling older participants were followed for a mean of 4.4 years. HU at baseline was defined using serum uric acid (SUA) concentrations ≥ 6 and 7 mg/dl for women and men, respectively. Objective physical performance tests measured included: Short Physical Performance Battery (SPPB), 4m gait speed, chair stands time, leg extension and flexion, handgrip strength, and the 6-Minute Walking Test (6MWT). At baseline, participants with HU (n=98 men; 232 women) scored significantly worse in all the tests investigated. After adjusting for 19 covariates, male participants with HU at baseline had an increased risk of having poor SPPB levels at follow-up (OR= 1.44, 95%CI: 1.21-1.72, p<0.0001), poor chair stands time (OR= 1.40, 95%CI: 1.18-1.67, p<0.0001), poor leg extension (OR= 1.47, 95%CI: 1.21-1.77, p<0.0001) and poor handgrip strength (OR= 1.54, 95%CI: 1.24-1.90, p<0.0001). Among women, HU was associated with an increased risk of having poor scores in all the SPPB items and in leg flexion (OR= 1.26, 95%CI: 1.08-1.49, p=0.03).
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Hyperuricemia seems to be significantly associated with poor physical performance in older people, over a follow-up of 4.4 years. The relationship appears to be more consistent in men than in women. Further longitudinal research is required to better understand the relationships and potential biological pathways. This article is protected by copyright. All rights reserved. Final Decision: yes