system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Which of the following is not a major criteria for diagnosis of multiple myeloma?
assistant
The correct answer is  "Lytic bone lesions" is not a major criteria for the diagnosis of multiple myeloma. It is a minor criteria for the diagnosis of multiple myeloma. So "Lytic bone lesions" is the single best answer of choice. Ref: The Washingtom Manual of Surgical Pathology: Depament of Pathology By Peter A Humphrey, Loius P.Dehner, Ohn D. Pfeifer, Page 565.