system
Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
A 61-year-old woman is brought to the emergency department because of fever, chills, and flank pain for 8 hours. Her temperature is 39.1°C (102.4°F). Physical examination shows right costovertebral angle tenderness. Urine dipstick is positive for nitrites. Urinalysis shows gram-negative rods. The patient is admitted to the hospital and treatment with a drug that directly inhibits bacterial DNA replication is begun. This drug inhibits a protein that is normally responsible for which of the following steps of DNA replication?
assistant
Cleaving DNA to relieve supercoils