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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: BACKGROUND, OBJECTIVE, METHODS, RESULTS. Meshes: Administration, Topical, Adult, Dentin Desensitizing Agents, Dentin Sensitivity, Double-Blind Method, Durapatite, Humans, Hydroxyapatites, Nanoparticles, Tooth Bleaching, Treatment Outcome.
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Do effect of a nano-hydroxyapatite paste on bleaching-related tooth sensitivity? Context: Bleaching-related tooth sensitivity has been shown to be facilitated by the presence of enamel defects. A nano-hydroxyapatite (n-HAP) paste has been shown to repair these defects. Using a randomized clinical trial, an n-HAP paste was investigated to determine its efficacy in reducing bleaching-related tooth sensitivity. An n-HAP paste (Renamel AfterBleach, Sangi Co., Ltd., Tokyo, Japan) and a placebo (zero-HAP) were randomly assigned for use in 42 participants. A 7% hydrogen peroxide gel was used twice daily for 14 days, with use of assigned desensitizer for 5 minutes immediately following. A diary was completed daily for 4 weeks to note: use of the agents and sensitivity on a visual analog scale (VAS). Three aspects of tooth sensitivity were investigated: percentage of participants; number of days; and intensity level. Color change was assessed. For Groups zero-HAP and n-HAP, respectively, 51 and 29% of participants reported tooth sensitivity (p = 0.06). Days of sensitivity were 76 and 36, respectively (p = 0.001). Change in VAS score from baseline trended higher for group zero-HAP (p = 0.16). Color change was equivalent.
assistant
The data trend indicated group n-HAP experienced less sensitivity over all three measures. Only the number of days of sensitivity was statistically significant. Final Decision: yes