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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: UNLABELLED, OBJECTIVE, RESULTS. Meshes: 9,10-Dimethyl-1,2-benzanthracene, Animals, Carcinogens, Cell Transformation, Neoplastic, Cytokines, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Mice, Mice, Inbred C57BL, Mice, Knockout, Pyridines, Reverse Transcriptase Polymerase Chain Reaction, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Skin Neoplasms.
user
Do mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model? Context: Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. To examine the role of MSK1/2 in skin tumor development. MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1β as well as the mRNA expression of TNF-α were significantly increased in MSK1/2 knockout mice.
assistant
These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis. Final Decision: yes