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Medical AI Inquiry: You were designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.
user
Leiden mutation involves:
assistant
The correct answer is  a. Factor V(Ref: Nelson's 20/e p 2384-2389, Ghai 8/e p 350-352)Factor V Leiden: glutamine arginine substitution at amino acid residue 506 that renders factor V resistant to cleavage and inactivation by protein C (also called Activated Protein C resistance)