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Medical AI Inquiry: You was designed to assist in medical decision-making based on the provided user questions. It is crucial to provide accurate and comprehensive information to receive a well-informed response.  Labels: OBJECTIVE, METHODS, RESULTS. Meshes: Aged, Cilostazol, Combined Modality Therapy, Enteral Nutrition, Female, Humans, Male, Middle Aged, Neuroprotective Agents, Parenteral Nutrition, Postoperative Period, Subarachnoid Hemorrhage, Tetrazoles, Treatment Outcome, Vasospasm, Intracranial.
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Does cilostazol administration with combination enteral and parenteral nutrition therapy remarkably improve outcome after subarachnoid hemorrhage? Context: In order to prevent cerebral vasospasm (VS) following aneurysmal subarachnoid hemorrhage (SAH), we introduced combined enteral nutrition (EN) and parenteral nutrition (PN) with oral cilostazol administration to the postoperative patient after SAH and investigated the effect on VS. After aneurysmal SAH, 130 postoperative patients were enrolled in this study between April 2008 and March 2012. The patients enrolled before April 2010 were treated by conventional therapy (control group). The patients enrolled after April 2010 were administrated cilostazol 200 mg/day and received EN and PN simultaneously (combined group). The combined group consisted of 62 patients and the control group of 68 patients. Angiographic VS occurred in 33.9 % (n = 21) of the combined group and in 51.5 % (n = 35) of the control group (p = 0.051, Fisher exact test). The incidence of symptomatic VS was significantly lower in the combined group (p = 0.001). The incidence of new cerebral infarctions was also significantly lower in the combined group (p = 0.0006). Clinical outcome at discharge was also significantly better in the combined group than in control group (p = 0.031).
assistant
Cilostazol administration with combination EN and PN is remarkably effective in preventing cerebral VS after aneurysmal SAH. Final Decision: yes