She is a graduate of Harvard College (B.A. in Biochemistry), and Harvard Medical School. Dr. Guinan completed a Residency in Pediatrics at Children’s Hospital Boston and a combined Pediatric Hematology/Oncology Fellowship at Children’s and the Dana Farber Cancer Institute. Her research laboratory has a primary focus on induction of alloantigen-specific tolerance via costimulatory blockade as a means of limiting transplant-related immunosuppression. She works in collaboration with Dr. Ofer Levy on studies of innate immunity in human transplantation, with a goal of employing innate defense molecules to prevent regimen-related toxicity in susceptible populations.