Her research seeks to define the contribution of extracellular mediators and blood and vascular cell-surface signaling receptors to test the pathways in clinical studies in humans. Her work has resulted in novel mechanistic insight into thrombo-inflammatory pathways and the generation of unique reagents, preclinical models, technology and new therapeutic strategies for vascular diseases. Her recent studies investigate pathways for production, metabolism, and biologic effects of lysophospholipid mediators in cardiovascular health disease. Her clinical interests are in arterial and venous thrombosis, and she leads an enterprise-wide effort in thrombosis prevention and management.