He is the co-founder of CareNex Health Services, Champion Health Enterprises, and Plymouth Health, the latter of which previously owned Alvarado Hospital in San Diego. He has served on numerous boards and is the youngest president in the history of the Los Angeles County Medical Association, a title he has held since 2014. Salimpour is also the first two-time recipient of the American College of Physicians' Research Award. As a keynote speaker he delivered the commencement address to the University of California, Riverside's 2008 graduating class, and gave the keynote address at the 2012 annual colloquium for the Whitehead Institute at MIT in 2012.