She primarily focused on maternal and women’s health especially antenatal primary care. Nontuthuzelo was a nurse educator for Eastern Cape nursing students and she was also involved with sexual and reproductive health research at the UCT Women’s Health Research Unit. Nontuthuzelo worked with the PPFSA in sexual and reproductive health supporting NGOs and she has in the employ of Kheth’Impilo as the manager for the training of community adherence workers now heading Community Services.