A native of South Texas, Pierce completed his undergraduate studies at the University of Texas–Pan American and his medical degree at Baylor College of Medicine. After completing his training at the Santa Rosa Family Medicine residency in 2007, he worked in Lesotho for a year as part of the Baylor College of Medicine Pediatric AIDS Corps. Since then he has divided his time between working in northern California and working as the Director of Education for World Altering Medicine, an NGO mainly focused on helping a community in central Malawi. In addition to his experience in southern Africa, Pierce has worked in Kenya, South Sudan, Mexico, Honduras, El Salvador, Guatemala, Peru, and the Philippines. His medical interests include high risk obstetrics, HIV, and tropical medicine, and he is dedicated to addressing health care needs in the developing world primarily through the teaching of medical practitioners.