True Blood is set in a 1917.
The Southern Vampire Mysteries . The series is narrated in first person perspective by Sookie Stackhouse , a waitress and a telepath in the fictional town of Bon Temps in northwestern Louisiana . True Blood . The series revolves around Sookie Stackhouse ( Anna Paquin ) , a telepathic waitress living in the rural town of Bon Temps , Louisiana , two years after the invention of a synthetic blood that has allowed vampires to `` come out of the coffin '' and allow their presence to be known to mankind .