Resident Evil's protagonist was portrayed by an actress.
Milica Bogdanovna `` Milla '' JovovichSerbian Cyrillic : Милица Јововић ; Милица Йовович Милиця Йовович ( [ ˈjoʊvəvɪtʃ ] ; born December 17 , 1975 ) is an American actress , model , musician , and fashion designer . Resident Evil (film) . The film stars Milla Jovovich and Michelle Rodriguez . Resident Evil (film series) . The films follow protagonist Alice , an original character created for the films portrayed by Milla Jovovich .