George W. Bush's paternal grandfather is the late Prescott Bush.
George W. Bush . From a prominent political family , he is the eldest son of Barbara and George H. W. Bush , the 41st President of the United States , making him only the second president to assume the nation 's highest office after his father , following the lead of John Quincy Adams . His paternal grandfather , Prescott Bush , was a United States Senator from Connecticut . Prescott Sheldon Bush , Sr. ( May 15 , 1895October 8 , 1972 ) was an American banker and senator . Samuel Prescott Bush ( October 4 , 1863 -- February 8 , 1948 ) was an American businessman and industrialist .