Mary-Louise Parker has performed as an actress.
Angels in America is a 2003 American HBO miniseries directed by Mike Nichols and based on the play by the same name written by Tony Kushner . Mary-Louise Parker ( born August 2 , 1964 ) is an American actress and author . In addition to her many films , Parker enjoyed great popularity for her lead role on Showtime 's television series Weeds portraying Nancy Botwin , for which she received the Golden Globe Award for Best Actress in 2006 . Parker is also the recipient of the 2001 Tony Award for Best Actress for her performance in the Broadway play Proof . Proof is a 2000 play by the American playwright David Auburn .