Venom is usually connected to Spiderman.
Venom (comics) . Venom made his first appearance in The Amazing Spider-Man # 300 ( May 1988 ) . The Venom Symbiote 's first known host was Spider-Man , who eventually separated himself from the creature when he discovered its true nature . Comics journalist and historian Mike Conroy writes of the character : `` What started out as a replacement costume for Spider-Man turned into one of the Marvel web-slinger 's greatest nightmares . ''