Arsenic and Old Lace stars Cary Grant.
Arsenic and Old Lace is a 1944 American dark comedy film directed by Frank Capra , starring Cary Grant , and based on Joseph Kesselring 's play Arsenic and Old Lace . The film 's supporting cast also features Priscilla Lane , Jack Carson , Edward Everett Horton and Peter Lorre . Arsenic and Old Lace (play) . It has become best known through the subsequent film adaptation starring Cary Grant and directed by Frank Capra .