Philadelphia is only home to small businesses.
Fortune 1000 is a reference to a list maintained by the American business magazine Fortune . Philadelphia . In the 19th century , Philadelphia became a major industrial center and railroad hub that grew from an influx of European immigrants . Philadelphia is the center of economic activity in Pennsylvania and is home to seven Fortune 1000 companies . Philadelphia is the birthplace of the United States Marine Corps , and is also the home of many U.S. firsts , including the first library ( 1731 ) , first hospital ( 1751 ) and medical school ( 1765 ) , first Capital ( 1777 ) , first stock exchange ( 1790 ) , first zoo ( 1874 ) , and first business school ( 1881 ) .