Hayden Panettiere was in a slasher film.
Hayden Panettiere . Other notable roles include her portrayal of the title character in the true crime drama Amanda Knox : Murder on Trial in Italy and Kirby Reed in the slasher film Scream 4 . Scream 4 ( stylized as SCRE4M ) is a 2011 American slasher film and the fourth and final installment in the Scream series . Directed by Wes Craven , his final feature film before his death in 2015 , and written by Kevin Williamson ( who returned to the series after writing the first two films ) , the film stars an ensemble cast which includes David Arquette , Neve Campbell , Courteney Cox , Emma Roberts , Hayden Panettiere , Anthony Anderson , Alison Brie , Adam Brody , Rory Culkin , Marielle Jaffe , Erik Knudsen , Mary McDonnell , Marley Shelton and Nico Tortorella .