Melissa McCarthy appeared in television.
Melissa McCarthy . From 2007 to 2009 , she appeared as Dena on the ABC sitcom Samantha Who ? McCarthy was then cast as Molly Flynn on the CBS sitcom Mike & Molly ( 2010 -- 2016 ) , earning a Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series as well as two other nominations during subsequent seasons . Mike & Molly is an American sitcom created by Mark Roberts which aired on CBS from September 20 , 2010 to May 16 , 2016 , for a total of six seasons and 127 episodes .