Maria Sharapova plays Dr. House on House.
Gregory House , M.D. , commonly referred to by his surname House , is the title character of the American medical drama series House . Created by David Shore and portrayed by English actor Hugh Laurie , he leads a team of diagnosticians as the Head of Diagnostic Medicine at the fictional Princeton-Plainsboro Teaching Hospital in Princeton , New Jersey ( based on the real-life Yale -- New Haven Hospital in New Haven , Connecticut ) . Maria Yuryevna Sharapova ( Мари́я Ю́рьевна Шара́пова ; born April 19 , 1987 ) is a Russian professional tennis player .