Katherine Heigl played a character.
Isabel Evans is a fictional character created by Melinda Metz for the young adults book series Roswell High and adapted by Jason Katims for the 1999-2002 American science fiction television series Roswell . Katherine Heigl . From 1999 to 2002 , Heigl co-starred as Isabel Evans on the television series Roswell . Heigl played Izzie Stevens on the ABC medical drama Grey 's Anatomy from 2005 to 2010 , a role for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series in 2007 . Heigl has also had a prominent film career , with appearances in Knocked Up ( 2007 ) , 27 Dresses ( 2008 ) , The Ugly Truth ( 2009 ) , Killers ( 2010 ) , Life As We Know It ( 2010 ) and New Year 's Eve ( 2011 ) . State of Affairs (TV series) . The series stars Katherine Heigl as CIA analyst Charleston Tucker , who is tasked with assembling and presenting the President 's Daily Briefing on the most vital security issues facing the country , and Alfre Woodard as the first black woman to be elected President of the United States , Constance Payton .