True Blood is about werewolves.
The Southern Vampire Mysteries . In The Southern Vampire Mysteries/True Blood Series , Harris develops a detailed mythology and alternate history that approaches supernatural beings as real ; at the beginning of the series , vampires ' existence has only been public knowledge for a couple of years , while other supernatural beings , such as werewolves , shapeshifters , faeries , etc. , exist but do not go public until later in the series . True Blood . television series produced and created by Alan Ball and based on The Southern Vampire Mysteries series of novels by Charlaine Harris . The series revolves around Sookie Stackhouse ( Anna Paquin ) , a telepathic waitress living in the rural town of Bon Temps , Louisiana , two years after the invention of a synthetic blood that has allowed vampires to `` come out of the coffin '' and allow their presence to be known to mankind .