James Wilson is a historical figure.
James Wilson ( September 14 , 1742 -- August 21 , 1798 ) was one of the Founding Fathers of the United States and a signatory of the United States Declaration of Independence . James Wilson (House) . The character first appears in the show 's pilot episode when he introduces a medical case to Dr. Gregory House . James Wilson ( 3 June 1805 -- 11 August 1860 ) was a Scottish businessman , economist , and Liberal politician who founded The Economist weekly and the Chartered Bank of India , Australia and China , which merged with Standard Bank in 1969 to form Standard Chartered .