Chicago White Sox competes in the American League.
Chicago White Sox . The White Sox compete in Major League Baseball ( MLB ) as a member club of the American League ( AL ) Central division . They are one of two major league clubs in Chicago ; the other is the Chicago Cubs , who are a member of the National League ( NL ) Central division . One of the American League 's eight charter franchises , the Chicago team was established as a major league baseball club in . In 1959 , led by Early Wynn , Nellie Fox , Luis Aparicio and manager Al Lopez , the White Sox won the American League pennant .