Henry VIII of England had a war with the Holy Roman Emperor Charles V.
Henry VIII of England . Despite the influx of money from these sources , Henry was continually on the verge of financial ruin due to his personal extravagance as well as his numerous costly continental wars , particularly with Francis I of France and the Holy Roman Emperor Charles V , as he sought to enforce his claim to the Kingdom of France . The Siege of Nice occurred in 1543 and was part of the Italian War of 1542 -- 46 in which Francis I and Suleiman the Magnificent collaborated in a Franco-Ottoman alliance against the Holy Roman Emperor Charles V , and Henry VIII of England .