Minnesota is a state in the Midwestern United States.
Midwestern United States . Other large Midwest cities include ( in order by population ) : Indianapolis , Columbus , Detroit , Milwaukee , Kansas City , Omaha , Minneapolis , Cleveland , Wichita and St. Louis . Minneapolis . As of 2015 , Minneapolis is the largest city in the state of Minnesota and 46th-largest in the United States with a population of 410,939 . Minnesota ( [ [ ˌmɪnəˈso̞ɾɐ ] help = no ] ) is a state in the midwestern and northern regions of the United States .