Multiple actors that star in The Comedian are American.
Charles Grodin ( born April 21 , 1935 ) is an American actor , comedian , author , and former cable talk show host . Cloris Leachman ( born April 30 , 1926 ) is an American actress and comedian . Daniel Michael DeVito , Jr. ( born November 17 , 1944 ) is an American actor , comedian , director and producer . Edith `` Edie '' Falco ( [ ˈiːdi_ˈfælkoʊ ] born July 5 , 1963 ) is an American television , film , and stage actress , known for her roles as Diane Whittlesey in the HBO series Oz ( 1997 -- 2000 ) , Carmela Soprano on the HBO series The Sopranos ( 1999 -- 2007 ) , the title character of the Showtime series Nurse Jackie ( 2009 -- 15 ) , and Sylvia Wittel on the Louis C.K. web series , Horace and Pete ( 2016 ) . Harvey Keitel ( [ kaɪˈtɛl ] ; born May 13 , 1939 ) is an American actor and producer . Leslie Mann ( born March 26 , 1972 ) is an American actress and comedian known for her roles in comedic films such as The Cable Guy ( 1996 ) , George of the Jungle ( 1997 ) , Big Daddy ( 1999 ) , Timecode ( 2000 ) , Perfume ( 2001 ) , Stealing Harvard ( 2002 ) , The 40-Year-Old Virgin ( 2005 ) , Knocked Up ( 2007 ) , 17 Again ( 2009 ) , Funny People ( 2009 ) , Rio ( 2011 ) , The Change-Up ( 2011 ) , This Is 40 ( 2012 ) , The Bling Ring ( 2013 ) , The Other Woman ( 2014 ) , Vacation ( 2015 ) and How to Be Single ( 2016 ) . Patti Ann LuPone ( born April 21 , 1949 ) is an American actress and singer , best known for her work in stage musicals . Robert Anthony De Niro ( [ dəˈnɪroʊ ] born August 17 , 1943 ) is an American actor , producer and director . The Comedian (2016 film) . The film stars Robert De Niro , Leslie Mann , Danny DeVito , Edie Falco , Veronica Ferres , Charles Grodin , Cloris Leachman , Patti LuPone and Harvey Keitel .