Lyme disease is transmitted by tick bite.
Lyme disease . The most common sign of infection is an expanding area of redness on the skin , known as erythema migrans , that begins at the site of a tick bite about a week after it has occurred . Lyme disease is transmitted to humans by the bite of infected ticks of the Ixodes genus . Prevention includes efforts to prevent tick bites such as by wearing long pants and using DEET .