Anti-nuclear antibodies has subtypes.
Antinuclear antibodies ( ANAs , also known as antinuclear factor or ANF ) are autoantibodies that bind to contents of the cell nucleus . There are many subtypes of ANAs such as anti-Ro antibodies , anti-La antibodies , anti-Sm antibodies , anti-nRNP antibodies , anti-Scl-70 antibodies , anti-dsDNA antibodies , anti-histone antibodies , antibodies to nuclear pore complexes , anti-centromere antibodies and anti-sp100 antibodies . Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus .