San Francisco is a city in California.
San Francisco ( initials SF ) ( [ sæn_frənˈsɪskoʊ ] , Spanish for Saint Francis ; Spanish : [ san franˈsisko ] ) , officially the City and County of San Francisco , is the cultural , commercial , and financial center of Northern California . With a density of about 18,581 people per square mile ( 7,174 people per km2 ) , San Francisco is the most densely settled large city ( population greater than 200,000 ) in California and the second-most densely populated major city in the United States after New York City . The California Gold Rush of 1849 brought rapid growth , making it the largest city on the West Coast at the time .