Katherine Heigl played a female character.
Isobel Katherine `` Izzie '' Stevens , M.D. is a fictional character from the medical drama television series Grey 's Anatomy , which airs on the American Broadcasting Company ( ABC ) in the United States . Katherine Heigl . From 1999 to 2002 , Heigl co-starred as Isabel Evans on the television series Roswell . Heigl played Izzie Stevens on the ABC medical drama Grey 's Anatomy from 2005 to 2010 , a role for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series in 2007 .