George W. Bush's paternal grandmother is Prescott Bush.
George H. W. Bush . Bush was born in Milton , Massachusetts , to Prescott Bush and Dorothy Walker Bush . George W. Bush . From a prominent political family , he is the eldest son of Barbara and George H. W. Bush , the 41st President of the United States , making him only the second president to assume the nation 's highest office after his father , following the lead of John Quincy Adams .