Julia Louis-Dreyfus plays the main character Selina Meyer in Veep.
Julia Louis-Dreyfus . She is known for her work in television comedy , including Saturday Night Live ( 1982 -- 85 ) , Seinfeld ( 1989 -- 98 ) , The New Adventures of Old Christine ( 2006 -- 10 ) , and Veep ( 2012 -- present ) . Other notable television roles include Christine Campbell in The New Adventures of Old Christine , which had a five-season run on CBS , and her role as Selina Meyer in Veep , which has recently been renewed by HBO for a sixth season . Veep is an American political satire comedy television series , starring Julia Louis-Dreyfus , that premiered on HBO on April 22 , 2012 . Veep is set in the office of Selina Meyer , a fictional Vice President , and subsequent President , of the United States .