Conan O'Brien hosts an American late-night talk show.
Conan is a late-night talk show airing each Monday through Thursday at 11:00 p.m. eastern time on TBS in the United States . Conan O'Brien . O'Brien was a writer and producer for The Simpsons for two seasons until he was commissioned by NBC to take over David Letterman 's position as host of Late Night in 1993 . Afterwards , O'Brien relocated from New York to Los Angeles to host his own incarnation of The Tonight Show for seven months until network politics prompted a host change in 2010 . With the retirement of David Letterman on May 20 , 2015 , O'Brien became the longest-working of all current late-night talk show hosts in the United States , at 22 years .