James Wilson is a character in a work of fiction.
House ( also called House , M.D. ) is an American television medical drama that originally ran on the Fox network for eight seasons , from November 16 , 2004 to May 21 , 2012 . Dr. James Evan Wilson , M.D. , is a fictional character on the Fox medical drama House . The character first appears in the show 's pilot episode when he introduces a medical case to Dr. Gregory House . Wilson is Dr. House 's only true friend , and frequently provides him with consultations and aid .