Less than 1% of dose-related material is excreted in urine and therefore renal impairment would not be expected to affect the pharmacokinetics of fluticasone furoate .. This sentence is hard to understand. A simpler version with equivalent meaning is the following:
Less than 1% of the administered dose is excreted in the urine . Also , renal impairment is not expected to affect the pharmacokinetics of fluticasone furoate .