Lumiracoxib does not accumulate in plasma under once or twice daily administration and steady state is achieved on the first day of administration with no increase in Cmax or AUC after extended dosing .. This sentence is hard to understand. A simpler version with equivalent meaning is the following:
Lumiracoxib does not accumulate in plasma on repeated once or twice daily administration . Steady state is achieved on the first day of administration , with no subsequent increase in Cmax or AUC after prolonged administration .