Because 14-OH-clarithromycin has reduced activity against Mycobacterium avium complex ( MAC ) , overall activity against this pathogen may be altered; therefore alternatives to clarithromycin should be considered for the treatment of MAC .
The above sentence is very complicated. Please provide me a simplified synonymous version consisting of multiple sentences:
Since 14-OH-clarithromycin has reduced activity against the Mycobacterium avium complex ( MAC ) , the overall activity against this pathogen may be impaired . Therefore , alternatives to clarithromycin should be considered for the treatment of MAC .