There are no data that support specific guidance for dosage adjustment in patients with hepatic impairment , but , due to safety considerations , Siklos is contraindicated in patients with severe hepatic impairment ( see section 4 . 2 ) .. This sentence is hard to understand. A simpler version with equivalent meaning is the following:
There are no data to support specific recommendations for dose adjustment in patients with hepatic impairment . However , for safety reasons Siklos is contraindicated in patients with severe hepatic impairment ( see section 4 . 2 ) .