L’œil et ses malaises : une histoire à retracer : effet délétère de l’inflammation médiée par interleukine-1 sur le développement nerveux et vasculaire de l’œil
Inflammation has an important role in preterm birth (PTB) and has been independently linked to many perinatal morbidities, including blindness. However, the specific role of gestational inflammation mediated by the interleukin (IL)-1 on vascular development in the eye hasn’t yet been defined. Using a murine model of IL-1 induced PTB, we studied that role in the developing retina and choroid, while testing a novel therapeutic approach targeting the IL-1 receptor, IL-1R. Pregnant mice were injected with IL-1 in utero to induce PTB. Subcutaneous injections of IL-1R antagonists were received by some of them: 101.10 (non-competitive) or Kineret (competitive). Progeny’s eyes were collected to measure inflammatory gene expression, which was elevated for Casp1, Il1b, Il8 and Il12. After the prenatal induction of inflammation, inflammatory cells infiltrate the retina and choroid before birth and stay present throughout development. After birth, pups exposed to IL-1 during gestation suffer from retinal vessel growth delay, choroidal and subsequent retinal thinning. This causes functional deficits on electroretinography, seen as a diminished b-wave amplitude. Antenatal administration of 101.10 was efficient in preventing those damages, whereas Kineret had a variable effect. Thus, uterine inflammation generates an inflammatory response in the eyes of the fetus, impairing vascular and retinal development and function. We suggest antenatal administration of 101.10 to protect the fetal eyes from deleterious inflammation and potential consequences on vision.
Inflammation Interleukine-1 101.10 Kineret Interleukin-1 Retina Choroid Angiogenesis Electroretinography Prematurity Mouse