L'impact des cellules souches issues de la moelle sur la néovascularisation dans un modèle de souris de rétinopathie induite par l'oxygène
Oxygen induced retinopathy (OIR) is an animal model that mimics the developing phases of retinopathies seen in humans such as diabetic retinopathy and retinopathy of prematurity.  An initial destruction of retinal microvasculature is followed by pathological neovascularization that can lead to retinal detachment in humans and therefore blindness.   Utilizing bone marrow derived stem cells (mesenchymal and hematopoietic), we aimed to repopulate the retina with normal vessels which are affected in the OIR model.   Cells injected into the vitreous migrated to the retina and reduced both the area of vasoobliteration and neovascularization.  Injection of conditioned cell medium also induced proper vascular repair similar to that seen in mice injected with cells indicating that the cells therapeutic effect is achieved through paracrine action.  These results suggest that bone marrow stem cells play a role in angiogenesis and could be a potential therapeutic aid in treating retinopathies.
Inflammation Stem cells Mesechymal stem cells Hematopoietic stem cells Retinopathy of prematurity Angiogenesis Ischemia Oxygen induced retinopathy