Modèles chirurgicaux de douleur arthrosique : évaluation fonctionnelle, biomarqueurs spinaux et développement de nouveaux modèles
The exact aetiology of osteoarthritic pain is only partially understood and the use of animal models is fundamental in the pathophysiological investigation and the development of therapeutic modalities, particularly the creation of a pathological chronic pain model. In the investigation of OA knee pain in rats, the intra-articular injection of sodium mono-iodo-acetate (MIA) is an overrepresented model.  However, this does not represent the natural disease in humans since the disease is acute, chemically induced, and temporary. We hypothesized that surgical models have the advantage of using mechanisms with better resemblance to the natural post-traumatic osteoarthritis. The model of transection of the cranial cruciate ligament, destabilization of the medial meniscus (partial medial meniscotomy) and their combination were evaluated in a pilot study with the objective to compare the pain behaviour and spinal neuromarkers between the surgical and MIA models. Surgical induction was accompanied by measurable neurophysiological changes associated with pathological pain and lasting longer than the MIA model, an advantage that can be applied in the evaluation of therapeutic modalities. Simple surgical models have proved to be without interest as they present temporary functional impairment without neuroproteomics modification.
Neuropeptides Pain Osteoarthritis Animal model Sodium mono-iodo-acetate Functional evaluations Biomarkers Neuropeptides