Évolution à long terme de 142 patients atteints d'un premier épisode de schizophrénie
Schizophrenia is defined in the literature as a severe and persistent mental disorder. Its prognosis is difficult to predict, as there is a paucity of recent long-term studies on the evolution of schizophrenia. This masters has two objectives:  (i) Describe the evolution of first episode schizophrenia patients by means of longitudinal studies with a follow-up of 10 years of more. (ii) Retrospectively describe the principal clinical and functional outcome measures of 142 first episode schizophrenia patients with a 27 to 31 year follow-up. Methods:  (i) The author conducted a systematic literature review, presenting articles with samples of first episode schizophrenia patients with a minimum follow-up of 10 years.  (ii) The author retrospectively evaluated the clinical and functional variables of 142 patients, using hospital charts and governmental health databases.  Results: (i) According to the literature, after a 10 year or more follow-up, 39,5 to 51,0% of patients are single and 25,6 to 54,0% are employed. The rate of suicide varied from 1,7 to 10,0%.  (ii) The number of hospitalizations in psychiatry decreased after the first 10 years, and 1/5 of patients did not require a re-hospitalization. More than half of patients received social assistance payments at study end. 14 patients died of suicide, half of which were during the first 10 years.  Conclusion: Schizophrenia is a mental disorder with severe consequences, but the evolution is heterogeneous.
first episode schizophrenia long term outcome prognosis functional outcome course