Étude de la composition de la bile chez le chat en santé et le chat atteint de cholangite
Hepatobiliary disease is common in cats and neutrophilic cholangitis is the most common type. There are 3 types of cholangitis but only neutrophilic cholangitis requires antibiotic treatment. However, antibiotics are sometimes incorrectly prescribed in patients, especially while pending results of a culture of bile or liver tissue, which is problematic in the context of current antimicrobial resistance.  Little is known about bile composition in healthy or diseased cats.   The aims of this study were to evaluate several analytes from the bile of healthy cats and to investigate the usefulness of measuring these variables to predict bacterial cholangitis.   Cats were prospectively enrolled and divided into 3 groups: 21 healthy cats (group 1); and 14 cats with suspected hepatobiliary disease: 9 without bacterial biliary infection (group 2) and 5 with bacterial biliary infection (group 3). Percutaneous ultrasound-guided cholecystocentesis was performed in each cat. Bile cytology and culture, as well as analysis of bile including pH, lactate, and glucose levels using several point-of-care devices, were performed.   Reference values for several bile analytes in healthy cats were calculated and are presented in this study. The pH was not significantly different between the 3 groups (p=0.88) nor was the lactate concentration (p=0.85). Sodium concentration was significantly higher in group 3 compared to group 2 (p<0.05). Bile pH, lactate, and glucose levels did not predict the presence of a bacterial infection in the bile.
Cholangite féline Bile composition Hepatobiliary disease Feline cholangitis Cholecystocentesis Point-of-care analyzers