Thérapie avec hormone de croissance en fécondation in vitro : une étude randomisée contrôlée
IVF protocols are constantly in revision to improve follicular development and increase the number of live births. Studies in mammals have shown that growth hormone (GH) was important for follicular development. The addition of GH could increase IVF pregnancy rates. This study is a randomized, controlled, open label trial including 528 participants into two groups receiving an ovarian stimulation antagonist protocol at the clinique ovo (Montréal). The women assigned to the treatment group will take 2.5mg/d of Saizen® subcutaneously following the patient’s stimulation medication. The primary objective is to determine if the clinical pregnancy rate after a fresh transfer in women receiving GH in addition to GnRH antagonist protocol is significantly higher than the control group. The secondary objectives are the outcomes of the stimulation cycle and pregnancy for fresh and frozen transfers. An analysis was performed in September 2016 to determine the interest of pursuing the study due to “Bill 20” which entails a decrease in recruitment. From June 2014 to September 2016 (date of the interim analysis), 212 patients were enrolled (n= 105 study group, n=107 control group), 96 patients in the study got oocytes retrieval and 98 in the control group. No statistically significant difference was observed in clinical pregnancy rate (33.33% study group VS 40.28% control group, p = 0.405). No statistically significant difference was observed for the mean number of oocytes retrieved (11.57 study group VS 9.65 control group, p = 0.064). The number of freeze all was significantly higher in the study group (15.63% VS 5.10% p = 0.016). All types of transfers, 101 transfers occurred in each group. 21 live birth were observed in the control group and 17 in the study group (p = 0.471). In conclusion, with the current data, the analysis performed cannot allow us to prescribe co- treatment with GH in antagonist protocol in normal-responders women. It is necessary to continue recruitment in order to increase the power of the results before confirming on using GH for these patients undergoing IVF treatments.
Fécondation in Vitro (FIV) In vitro fertilization (IVF) Growth Hormone (GH) Ovarian stimulation Antagonist protocol Pregnancy rate