Évaluation de l'effet inhibiteur de 33 espèces végétales sur la lipase pancréatique in vitro
Type 2 diabetes and obesity affect the global population and, disproportionately, the adult population of the Eeyou Istchee Cree. In order to contribute to the documentation of the antidiabetic activities of 17 medicinal plants of the boreal forest traditionally recommended for treating the symptoms of diabetes, this study evaluates the pancreatic lipase enzymatic activity of different plant species. In addition, an evaluation of the enzymatic activity of the pancreatic lipase is carried out with antidiabetic species of the urban pharmacopoeia of Niamey (Niger) as well as with Quebec berries. Finally, phenolic compounds are identified in these last two groups of plant species. Results of these studies demonstrate that the majority of the evaluated species have an inhibitory effect on pancreatic lipase in vitro. Species showing the strongest inhibitory activities towards pancreatic lipase are Kalmia angustifolia, Gaultheria hispidula and Acacia nilotica. Thus, this study supports the accuracy of traditionnal knowledge by adding the documentation of an antidiabetic activity of plant species to the scientific repertoire.
Eeyou Istchee Cri Niger pancreatic lipase medicinal plants Eeyou Istchee Cree obesity diabetes Niger berries Indigenous Traditional Medicine natural health products