CROSS-REFERENCE TO RELATED APPLICATIONS

This patent application is based on and claims priority pursuant to 35 U.S.C. § 119(a) to Japanese Patent Application No. 2019-052246, filed on Mar. 20, 2019, in the Japan Patent Office, the entire disclosure of which is hereby incorporated by reference herein.

BACKGROUND

Technical Field

The present disclosure relates to a sheet, a sheet laminate, a pharmaceutical drug, a sheet producing method, a sheet producing apparatus, a sheet laminate producing method, and a sheet laminate producing apparatus.

Description of the Related Art

Hitherto, in the field of pharmaceutical production, pharmaceutical drugs each containing a plurality of kinds of bioactive substances have been produced.

Such pharmaceutical drugs that have been proposed include a pharmaceutical composition obtained by modeling particles of a pharmaceutical composition containing one or more kinds of bioactive substances, using a powder additive manufacturing-type three-dimensional object producing method, in order to provide a rapidly dispersible dosage form.

Another proposed example is a laminated film obtained by sequentially laminating a gastric-soluble film and an enteric film each containing a pharmacologically active substance that releases one or more kinds of substances depending on the ambient conditions.

SUMMARY

According to an aspect of the present disclosure, a sheet includes a base material comprising a biocompatible material and having at least two independent holes, and a bioactive substance. The independent holes include at least one independent hole A containing the bioactive substance. The independent holes include at least one independent hole B containing no bioactive substance. The maximum diameter of the independent holes is less than 0.2 mm.

