CROSS REFERENCE TO RELATED APPLICATIONS

This application is a United States Application under 35 C.F.R. 371 claiming benefit of PCT Application No. PCT/US2015/066642, filed on Dec. 18, 2015, which claims priority benefit of U.S. Provisional Application No. 62/093,533, filed Dec. 18, 2014.

The present invention relates to oral care compositions comprising ionic tin and in particular to mouth rinse formulations comprising ionic tin.

BACKGROUND

Tin ions such as stannous ions are incorporated into oral care compositions including dentifrices and mouth rinses in order to provide a variety of oral care benefits including anticaries activity and for the treatment and/or prevention of gingivitis. However, the use of oral care compositions comprising ionic tin can lead to staining of the teeth and tongue in certain product users. It would therefore be desirable to be able to provide oral care compositions comprising tin ions that maintain beneficial oral care properties such as antibacterial activity, but result in reduced staining.

BRIEF SUMMARY

It has now surprisingly been discovered that incorporating polyvinylpyrrolidone into oral care mouth rinses comprising ionic tin can lead to a reduction in tooth staining without compromising oral care efficacy.

According to a first aspect of the present invention there is provided an oral care mouth rinse composition comprising(i) at least one source of ionic tin and(ii) polyvinylpyrrolidone
wherein the polyvinylpyrrolidone is present in an amount of from 1.5 to 4 weight % based on the total weight of the oral care mouth rinse composition.

Optionally the polyvinylpyrrolidone is present in an amount of from 2.20 to 3.00 weight % based on the total weight of the oral care mouth rinse composition. Further optionally the polyvinylpyrrolidone is present in an amount of from 2.20 to 2.50 weight % based on the total weight of the oral care mouth rinse composition. Further optionally the polyvinylpyrrolidone is present in an amount of from 2.30 to 2.45 weight % based on the total weight of the oral care mouth rinse composition.

Optionally the oral care mouth rinse comprises at least one stannous ion source, at least one stannic ion source or a combination thereof. Optionally the oral care mouth rinse comprises at least one stannous ion source. Optionally the at least one source of ionic tin is selected from the group comprising stannous fluoride, stannic fluoride, stannic chloride, stannic acetate, stannous chloride, stannous acetate and combinations thereof. Optionally the at least one source of ionic tin is selected from the group comprising stannous fluoride, stannous chloride, stannous acetate and combinations thereof.

Optionally the concentration of ionic tin is from 0.01 to 0.10 weight % based on the total weight of the oral care mouth rinse composition. Further optionally the concentration of ionic tin is from 0.02 to 0.08 weight % based on the total weight of the oral care mouth rinse composition. Further optionally the concentration of ionic tin is from 0.03 to 0.06 weight % or from 0.035 to 0.045 weight % based on the total weight of the oral care mouth rinse composition.

Optionally the at least one source of ionic tin comprises stannous fluoride.

Optionally the oral care mouth rinse composition further comprises a fluoride ion source which is not a tin salt, further optionally in an amount corresponding to 0.01 to 0.15 weight % fluoride based on the total weight of the composition. Further optionally the oral care mouth rinse composition comprises a fluoride ion source selected from sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride and combinations thereof, even further optionally in an amount corresponding to 0.01 to 0.15 weight % fluoride based on the total weight of the composition.

Optionally the oral care mouth rinse composition comprises amine fluoride, sodium fluoride or a combination thereof. Further optionally the oral care mouth rinse composition comprises 0.02 to 0.08 weight % stannous fluoride and 0.010 to 0.50 weight % amine fluoride.

Optionally the oral care mouth rinse composition comprises 50 to 1500 ppm fluoride.

Optionally the oral care mouth rinse composition comprises polyvinylpyrrolidone having a molar mass of from 10,000 to 300,000 Daltons.

According to a further aspect of the present invention there is also provided a method toi. reduce or inhibit formation of dental caries,ii. reduce, repair or inhibit pre-carious lesions of the enamel,iii. reduce or inhibit demineralization and promote remineralization of the teethiv. reduce hypersensitivity of the teeth,v. reduce or inhibit gingivitis,vi. promote healing of sores or cuts in the oral cavity,vii. reduce levels of acid producing bacteriaviii. reduce or inhibit microbial biofilm formation in the oral cavity,ix. reduce or inhibit plaque formation in the oral cavityx. promote systemic healthxi. clean teeth and oral cavity
the method comprising applying an effective amount of an oral care mouth rinse composition to the oral cavity of a subject in need thereof.

According to a further aspect of the invention there is also provided an oral care mouth rinse composition for use in a method toi. reduce or inhibit formation of dental caries,ii. reduce, repair or inhibit pre-carious lesions of the enamel,iii. reduce or inhibit demineralization and promote remineralization of the teethiv. reduce hypersensitivity of the teeth,v. reduce or inhibit gingivitis,vi. promote healing of sores or cuts in the oral cavity,vii. reduce levels of acid producing bacteriaviii. reduce or inhibit microbial biofilm formation in the oral cavity,ix. reduce or inhibit plaque formation in the oral cavityx. promote systemic healthxi. clean teeth and oral cavity.

According to a further aspect of the invention there is also provided use of an oral care mouth rinse composition toi. reduce or inhibit formation of dental caries,ii. reduce, repair or inhibit pre-carious lesions of the enamel,iii. reduce or inhibit demineralization and promote remineralization of the teethiv. reduce hypersensitivity of the teeth,v. reduce or inhibit gingivitis,vi. promote healing of sores or cuts in the oral cavity,vii. reduce levels of acid producing bacteriaviii. reduce or inhibit microbial biofilm formation in the oral cavity,ix. reduce or inhibit plaque formation in the oral cavityx. promote systemic healthxi. clean teeth and oral cavity
in a subject in need thereof.

According to a further aspect of the invention there is provided a method of reducing staining of surfaces in the oral cavity resulting from use of an oral care mouth rinse comprising at least one source of ionic tin, wherein the method comprises formulating the oral care mouth rinse composition to comprise polyvinylpyrrolidone in an amount of from 2.20 to 3.00 weight % based on the total weight of the oral care mouth rinse composition. Optionally the method comprises formulating the oral care mouth rinse composition to comprise from 2.30 to 2.45 weight % polyvinylpyrrolidone. Optionally the concentration of ionic tin in the oral care mouth rinse composition is from 0.02 to 0.08 weight % based on the total weight of the oral care mouth rinse composition.

Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention. The formulation may include a first feature described in one example configuration herein, as well as a second feature described in another example configuration herein. In other words, the invention contemplates mixing and matching features from the disclosed embodiments in various combinations.

