FIELD OF THE INVENTION

The present application relates to compounded therapies. In particular, the present application relates to compositions for compounded therapy and methods of compounding medications.

BACKGROUND

Transdermal creams are employed to deliver medication to the skin of a patient. Conventional compositions intended for topical administration include EMLA cream, a eutectic mixture of lidocaine and prilocaine in an emulsified topical cream, such as disclosed by U.S. Pat. Nos. 6,299,902 and 4,562,060, which are incorporated herein by reference in their entireties. However, conventional transdermal creams may include various drawbacks, such as addressing limited medical conditions, creating adverse side effects, and/or having limited shelf lives. Additionally, conventional methods of manufacturing transdermal creams may be inefficient and/or lack precision with the amount of active ingredients, or have other drawbacks.

SUMMARY

The present embodiments may relate to topically delivered compounded medications for treatment of various ailments, such as pain, osteoarthritis, epilepsy, inflammation, muscle fatigue, spasms, and/or other ailments. In one aspect, a transdermal cream for the effective administration of multiple medications simultaneously for one or more ailments may be provided. The transdermal cream may include low concentrations of lidocaine, prilocaine, meloxicam, and lamotrigine and/or topiramate. Alternatively, the transdermal cream may include a base having lidocaine and prilocaine to which is added a fine powder of one or more medications. The medication in powder form may be generated from grinding up tablets of NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), nerve depressants, anticonvulsants, antidepressants, muscle relaxants, anesthetics, and/or other active ingredients. The present embodiments also relate to methods of making the compositions discussed herein.

In one aspect, a compounded transdermal cream for topical administration of a compounded therapy includes a nerve depressant such as gabapentin in an amount between approximately 5% and 15% by weight of the transdermal cream. The compounded transdermal cream may also include an NSAID (Non-Steroidal Anti-Inflammatory Drug) such as nabumetone in an amount between approximately 5% and approximately 25% by weight of the transdermal cream. The compounded transdermal cream may also include a tricyclic antidepressant such as amitriptyline in an amount between approximately 0.5% and approximately 4% by weight of the transdermal cream. The compounded transdermal cream may also include a local anesthetic such as lidocaine and prilocaine in an amount between approximately 1% and approximately 7% by weight of the transdermal cream. The compounded transdermal cream may also include dimethyl sulfoxide (DMSO).

In one formulation, the gabapentin may be present in an amount approximately 6% by weight of the transdermal cream, the nabumetone may be present in an amount approximately 10% by weight of the transdermal cream, the amitriptyline may be present in an amount approximately 2% by weight of the transdermal cream, and the lidocaine and prilocaine may each be present in an amount approximately 1.5% by weight of the transdermal cream. The DMSO may be present in an amount approximately 20% by weight of the transdermal cream. A thickening agent may also be present in an amount approximately 2% by weight of the transdermal cream.

In another aspect, a compounded transdermal cream includes gabapentin in an amount approximately 6% by weight of the transdermal cream, nabumetone in an amount approximately 10% by weight of the transdermal cream, amitriptyline in an amount approximately 2% by weight of the transdermal cream, lidocaine and prilocaine cream (2.5%/2.5%) in an amount approximately 60% by weight of the transdermal cream such that the transdermal cream comprises lidocaine in an amount approximately 1.5% by weight of the transdermal cream and prilocaine in an amount approximately 1.5% by weight of the transdermal cream, dimethyl sulfoxide (DMSO) in an amount approximately 20% by weight of the transdermal cream, and a thickening agent in an amount approximately 2% by weight of the transdermal cream.

In yet another aspect, a method of compounding a transdermal cream includes wetting a plurality of dry powder active agents with dimethyl sulfoxide (DMSO) and mixing the wetted dry powder active agents with a lidocaine and prilocaine cream (2.5%/2.5%). The dry powder active agents may include gabapentin, nabumetone, and amitriptyline. The gabapentin may be present in the transdermal cream in an amount between approximately 5.0% and 15.0% by weight of the transdermal cream. The nabumetone may be present in an amount of between approximately 5.0% and approximately 25% by weight of the transdermal cream. The amitriptyline may be present in an amount between approximately 0.5% and approximately 4.0% by weight of the transdermal cream.

In one formulation, the gabapentin may be present in an amount approximately 6% by weight of the transdermal cream, the nabumetone may be present in an amount approximately 10% by weight of the transdermal cream, the amitriptyline may be present in an amount approximately 3% by weight of the transdermal cream, and the lidocaine and prilocaine may each be present in an amount approximately 1.5% by weight of the transdermal cream. The DMSO may be present in an amount approximately 20% by weight of the transdermal cream. The method may further include adding a thickening agent to the lidocaine and prilocaine cream (2.5%/2.5%) before or after mixing the wetted dry powder active ingredients with the lidocaine and prilocaine cream (2.5%/2.5%). The thickening agent may be present in an amount approximately 2% by weight of the transdermal cream.

The above-described and other features and advantages of the present disclosure will be appreciated and understood by those skilled in the art from the following detailed description, drawings, and appended claims.

