BACKGROUND OF THE INVENTION

A. Field of the Invention

The present invention relates generally to compositions that include one or any combination of botanical extracts selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts. In particular aspects, the compositions include aNymphaea giganteaextract, aSyzygium mooreiextract, aCupaniopsis anacardioidesextract, aArchidendron hendersoniiextract, aTristaniopsis laurinaextract, aBrachychiton acerifoliusextract, or aStenocarpus sinuatusextract, or any combination thereof. The compositions can be formulated as topical skin compositions, edible compositions, injectible compositions, oral compositions, hair care compositions, etc.

B. Description of Related Art

Ageing, chronic exposure to adverse environmental factors, malnutrition, fatigue, etc., can change the visual appearance, physical properties, or physiological functions of skin in ways that are considered visually undesirable. The most notable and obvious changes include the development of fine lines and wrinkles, loss of elasticity, increased sagging, loss of firmness, loss of color evenness or tone, coarse surface texture, and mottled pigmentation. Less obvious, but measurable changes which occur as skin ages or endures chronic environmental insult include a general reduction in cellular and tissue vitality, reduction in cell replication rates, reduced cutaneous blood flow, reduced moisture content, accumulated errors in structure and function, alterations in the normal regulation of common biochemical pathways, and a reduction in the skin's ability to remodel and repair itself. Many of the alterations in appearance and function of the skin are caused by changes in the outer epidermal layer of the skin, while others are caused by changes in the lower dermis.

Previous attempts to improve the visual appearance of skin with known skin active-ingredients have been shown to have various drawbacks such as skin irritation and prolonged recovery periods.

SUMMARY OF THE INVENTION

The present invention provides an effective alternative to existing skin active-ingredients that are used with topical application to keratinous tissue (e.g., skin, hair, nails, etc.). In this regard, the compositions of the present invention can include an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The compositions can be formulated as topical skin compositions, edible compositions, injectible compositions, oral compositions, hair care compositions, etc. In particular aspects, the compositions can include at least two, three, four, five, six, seven, eight, nine, ten, eleven, or all twelve of these extracts. The extract can be obtained from any part of the plant. Non-limiting examples include extracts obtain from the whole plant, leaves, stems, flowers, flower buds, bark, roots, fruit, seeds, seed pods, and any mixture of such parts. In certain aspects, the extract can be obtained from the whole fruit (e.g., fruit pulp and seeds), the whole plant (e.g., the entire plant is used to produce the extract), a particular part of the plant at the exclusion of another part (e.g., seed extract isolated from other parts of the plant), etc. The extract can be water-based, alcohol-based, oil-based, gel-based etc. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In certain embodiments, the compositions are formulated into topical skin or hair care compositions. The compositions can be cosmetic compositions. The compositions can be formulated as emulsions (e.g., oil-in-water, water-in-oil, silicone-in-water, water-in-silicone, water-in-oil-in-water, oil-in-water, oil-in-water-in-oil, oil-in-water-in-silicone, etc.), creams, lotions, solutions (e.g., aqueous or hydro-alcoholic solutions), anhydrous bases (e.g., lipstick or a powder), gels, ointments, milks, pastes, aerosols, solid forms, eye jellies, etc. The compositions can also be formulated for topical skin application at least 1, 2, 3, 4, 5, 6, 7, or more times a day during use. In other aspects of the present invention, compositions can be storage stable or color stable, or both. It is also contemplated that the viscosity of the composition can be selected to achieve a desired result, e.g., depending on the type of composition desired, the viscosity of such composition can be from about 1 cps to well over 1 million cps or any range or integer derivable therein (e.g., 2 cps, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 20000, 30000, 40000, 50000, 60000, 70000, 80000, 90000, 100000, 200000, 300000, 400000, 500000, 600000, 700000, 800000, 900000, 1000000 cps, etc., as measured on a Brookfield Viscometer using a TC spindle at 2.5 rpm at 25° C.).

The compositions of the present invention can include any desired amount ofNymphaea giganteaextract,Syzygium mooreiextract,Cupaniopsis anacardioidesextract,Archidendron hendersoniiextract,Tristaniopsis laurinaextract,Brachychiton acerifoliusextract,Stenocarpus sinuatusextract,Alphitonia excelsaextract,Eucalyptus coolabahextract,Plumeria albaextract,Cocos nuciferaextract, orTamarindus indicaextract, or any combination of such extracts. The amount of the extracts can individually or combined be from 0.0001, 0.0002, 0.0003, 0.0004, 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 95, 96, 97, 98, 99%, or more, or any range derivable therein, by weight or volume of the extract or combination of extracts.

The compositions of the present invention can also be modified to have a desired oxygen radical absorbance capacity (ORAC) value. In certain non-limiting aspects, the compositions of the present invention or the plant extracts identified throughout this specification can be modified to have an ORAC value per mg of at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 95, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 15000, 20000, 30000, 50000, 100000 or more or any range derivable therein.

The compositions in non-limiting aspects can have a pH of about 6 to about 9. In other aspects, the pH can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14. The compositions can include a triglyceride. Non-limiting examples include small, medium, and large chain triglycerides. In certain aspects, the triglyceride is a medium chain triglyceride (e.g., caprylic capric triglyceride). The compositions can also include preservatives. Non-limiting examples of preservatives include methylparaben, propylparaben, or a mixture of methylparaben and propylparaben.

Compositions of the present invention can have UVA and UVB absorption properties. The compositions can have an sun protection factor (SPF) of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, or more, or any integer or derivative therein. The compositions can be sunscreen lotions, sprays, or creams.

In one aspect of the present invention, there is disclosed a topical skin care composition that includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts, in combination with any one of, any combination of, or all of the following additional ingredients: water, a chelating agent, a moisturizing agent, a preservative, a thickening agent, a silicone containing compound, an essential oil, a structuring agent, a vitamin, a pharmaceutical ingredient, or an antioxidant, or any combination of such ingredients or mixtures of such ingredients. In certain aspects, the composition can include at least two, three, four, five, six, seven, eight, nine, ten, or all of these additional ingredients identified in the previous sentence. Non-limiting examples of these additional ingredients are identified throughout this specification and are incorporated into this section by reference. The amounts of such ingredients can range from 0.0001% to 99.9% by weight or volume of the composition, or any integer or range in between as disclosed in other sections of this specification, which are incorporated into this paragraph by reference. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In another embodiment, there is disclosed a topical skin care composition that includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts, in combination with any one of, any combination of, or all of the following ingredients: water; glycerin; butylene glycol; propylene glycol; phenoxyethanol; a chelating agent (e.g., EDTA, disodium EDTA, trisodium EDTA, EGTA, disodium EGTA, trisodium EGTA, citric acid, phosphoric acid, succinic acid, etc.); steareth-20; chlorhexidine diglunonate; potassium sorbate; and/or a preservative (e.g., methylparaben, propylparaben, butylparaben, ethylparaben, isobutylparaben, etc.). In particular aspects, the composition can further include any one of, any combination of, or all of the following additional ingredients: alcohol; denatured alcohol; glyceryl stearate; dimethicone; PEG-100 stearate; capryl glycol; triethanolamine; maltodextrin; sorbic acid; ethylene brassylate; methyl linalool; isobutyl methyl tetrahydropyranol; ethylhexylglycerin; and/or hexylene glycol. The concentrations of these ingredients can range from 0.00001 to 99% by weight or volume of the composition or any integer or range derivable therein as explained in other portions of this specification which are incorporated into this paragraph by reference. In particular aspects, the concentration of water can be at least 35% to 80% by weight of water. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In another aspect of the invention, there is disclosed a topical skin care composition that includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts, in combination with any one of, any combination of, or all of the following ingredients: water; dimethicone; triethanolamine; phenonip; betaine; a chelating agent (e.g., EDTA, disodium EDTA, trisodium EDTA, EGTA, disodium EGTA, trisodium EGTA, citric acid, phosphoric acid, succinic acid, etc.); tocopheryl acetate; and/or prodew 400. In particular aspects, the composition can further include any one of, any combination of, or all of the following additional ingredients: propylene glycol; isododecane; polyacrylamide/C13-C14 isoparaffin/laureth 7 mixture; PEG-12 dimethicone; and/or ethylhexyl palmitate. The concentrations of these ingredients can range from 0.00001 to 99% by weight or volume of the composition or any integer or range derivable therein as explained in other portions of this specification which are incorporated into this paragraph by reference. In particular aspects, the concentration of water can be at least 35% to 80% by weight of water. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In yet another embodiment there is disclosed a topical skin care composition that includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts, in combination with any one of, any combination of, or all of the following ingredients: water; glycerin; pentylene glycol; capryl glycol; disodium EDTA; capric/caprylic triglyceride; shea butter; squalane; cetyl alcohol; dimethicone; ceramide II; stearic acid; a mixture of glyceryl stearate and PEG 100 stearate; or a mixture of acrylamide/acryloyl dimethyl taurate copolymer, isohexadecane, and polysorbate 80. The concentrations of these ingredients can range from 0.00001 to 99% by weight or volume of the composition or any integer or range derivable therein as explained in other portions of this specification which are incorporated into this paragraph by reference. In particular aspects, the concentration of water can be at least 35% to 80% by weight of water. The ratio of water to glycerin can be from about 7:1 to 9:1 based on the total weight of the composition. The ratio of glycerin to pentylene glycol can be from about 1:1 to about 2:1 based on the total weight of the composition. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

There is also disclosed a topical skin care composition that includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts, in combination with any one of, any combination of, or all of the following ingredients: water; glycerin; capryl glycol; capryl glycol; disodium EDTA; petrolatum; squalane; cetyl alcohol; a mixture of glyceryl stearate and PEG 100 stearate; dimethicone; or a mixture of acrylamide/acryloyl dimethyl taurate copolymer, isohexadecane, and polysorbate 80. The concentrations of these ingredients can range from 0.00001 to 99% by weight or volume of the composition or any integer or range derivable therein as explained in other portions of this specification which are incorporated into this paragraph by reference. In particular aspects, the concentration of water can be at least 35% to 80% by weight of water. The ratio of water to glycerin can be from about 12:1 to 16:1 based on the total weight of the composition. The ratio of glycerin to pentylene glycol can be from about 0.5:1 to about 1.5:1 based on the total weight of the composition. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

Also disclosed is a topical skin care composition that includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts, in combination with any one of, any combination of, or all of the following ingredients: water; xanthan gum; disodium EDTA; pentylene glycol; capryl glycol; acrylate C10-30 acrylate cross polymer; triethanolamine; PVP/hexadecene copolymer; C12-15 alkyl benzoate; sorbitan isostearate; or a sunscreen agent. The concentrations of these ingredients can range from 0.00001 to 99% by weight or volume of the composition or any integer or range derivable therein as explained in other portions of this specification which are incorporated into this paragraph by reference. In particular aspects, the concentration of water can be at least 35% to 80% by weight of water. The ratio of water to C12-15 alkyl benzoate can be from about 2:1 to 3:1 based on the total weight of the composition. The ratio of water to pentylene glycol can be from about 9:1 to about 11:1 based on the total weight of the composition. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In yet another embodiment, there is disclosed a topical skin care composition that includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination of such extracts, in combination with any one of, any combination of, or all of the following ingredients: water; disodium EDTA; citric acid; pentylene glycol; capryl glycol; sodium cocoamphodiacetate; or sodium methyl cocoyl taurate. The concentrations of these ingredients can range from 0.00001 to 99% by weight or volume of the composition or any integer or range derivable therein as explained in other portions of this specification which are incorporated into this paragraph by reference. In particular aspects, the concentration of water can be at least 35% to 80% by weight of water. The ratio of water to pentylene glycol can be from about 12:1 to 14:1 based on the total weight of the composition. The ratio of water to sodium cocoamphodiacetate can be from about 8:1 to about 11:1 based on the total weight of the composition. The ratio of water to sodium methyl cocoyl taurate can be from about 2:1 to about 4:1 based on the total weight of the composition. The ratio of sodium methyl cocoyl taurate to sodium cocoamphodiacetate can be from about 2:1 to about 4:1 based on the total weight of the composition. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In one embodiment of the present invention there is disclosed a method of reducing the appearance of symptoms associated with erythema (e.g., erythemic skin, sensitive skin, inflamed skin) comprising topically applying a composition to erythemic, sensitive, or inflamed skin wherein the composition includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination thereof and a dermatologically acceptable vehicle, wherein topical application of the composition to erythemic, sensitive, or inflamed skin reduces the appearance of symptoms associated with erythema, sensitive skin, or inflamed skin. In particular aspects, the composition includesNymphaea giganteaextract. Further, the compositions described throughout the specification and claims can be used with this method. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

Also disclosed is a method of treating erythema comprising topically applying a composition to erythemic skin, sensitive skin, or inflamed skin, wherein the composition includes: an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination thereof; and a dermatologically acceptable vehicle, wherein topical application of the composition to erythemic skin treats erythema, sensitive skin, or inflamed skin. In particular aspects, the composition includesNymphaea giganteaextract. Further, the compositions described throughout the specification and claims can be used with this method. Erythema can be caused by skin sunburn, electrical treatments of skin, skin burns, contact allergies, systemic allergies, skin toxicity, exercise, insect stings, bacterial infection, viral infection, fungal infection, protozoa infection, massage, windburn, etc. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In still another aspect of the present invention there is disclosed a method of treating dry, flaky, or itchy skin or reducing the appearance of uneven skin tone comprising topically applying a composition to dry, flaky, or itchy skin or to skin having an uneven skin tone, wherein the composition includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination thereof; and a dermatologically acceptable vehicle. In particular aspects, the composition includesNymphaea giganteaextract. Further, the compositions described throughout the specification and claims can be used with this method. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

Also disclosed is a method of reducing the appearance of fine lines or wrinkles comprising topically applying a composition to skin having fine lines or wrinkles, wherein the composition includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination thereof; and a dermatologically acceptable vehicle, wherein topical application of the composition to fine lines or wrinkles reduces the appearance of the fine lines or wrinkles. In particular aspects, the composition includesNymphaea giganteaextract. Further, the compositions described throughout the specification and claims can be used with this method. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In one embodiment of the present invention there is disclosed a method of reducing pain associated with erythema, sensitive skin, or inflamed skin, comprising topically applying a composition to erythemic, sensitive, or inflamed skin wherein the composition includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination thereof; and a dermatologically acceptable vehicle, wherein topical application of the composition to erythemic, sensitive, or inflamed skin reduces the pain associated with erythema, sensitive skin, or inflamed skin. In particular aspects, the composition includesNymphaea giganteaextract. Further, the compositions described throughout the specification and claims can be used with this method. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In another embodiment there is disclosed a method of treating or preventing a skin condition comprising topically applying a composition to skin having a skin condition, wherein the composition includes an extract selected from the group consisting of:Nymphaea giganteaextract;Syzygium mooreiextract;Cupaniopsis anacardioidesextract;Archidendron hendersoniiextract;Tristaniopsis laurinaextract;Brachychiton acerifoliusextract;Stenocarpus sinuatusextract;Alphitonia excelsaextract;Eucalyptus coolabahextract;Plumeria albaextract;Cocos nuciferaextract; andTamarindus indicaextract; and any combination thereof; and a dermatologically acceptable vehicle, wherein topical application of the composition to the skin condition treats the skin condition. In particular aspects, the composition includesNymphaea giganteaextract. Further, the compositions described throughout the specification and claims can be used with this method. Non-limiting examples of skin conditions include dry skin, itchy skin, inflamed skin, erythema, sensitive skin, pruritus, spider veins, lentigo, age spots, senile purpura, keratosis, melasma, blotches, fine lines or wrinkles, nodules, sun damaged skin, dermatitis (including, but not limited to seborrheic dermatitis, nummular dermatitis, contact dermatitis, atopic dermatitis, exfoliative dermatitis, perioral dermatitis, and stasis dermatitis), psoriasis, folliculitis, rosacea, acne, impetigo, erysipelas, erythrasma, eczema, sun burns, burned skin, open wounds, skin-inflammatory skin conditions, etc. In certain non-limiting aspects, the skin condition can be caused by exposure to UV light, age, irradiation, chronic sun exposure, environmental pollutants, air pollution, wind, cold, heat, chemicals, disease pathologies, smoking, or lack of nutrition. The skin can be facial skin or non-facial skin (e.g., arms, legs, hands, chest, back, feet, etc.). The method can further comprise identifying a person in need of skin treatment. The person can be a male or female. The age of the person can be at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or more years old, or any range derivable therein. The method can also include topically applying an amount effective to: increase the stratum corneum turnover rate of the skin; increase collagen synthesis in fibroblasts; increase cellular anti-oxidant defense mechanisms (e.g., exogenous additions of anti-oxidants can bolster, replenish, or prevent the loss of cellular antioxidants such as catalase and glutathione in skin cells (e.g., keratinocytes, melanocytes, langerhans cells, etc.) which will reduce or prevent oxidative damage to the skin, cellular, proteins, and lipids); inhibit melanin production in melanocytes; reduce or prevent oxidative damage to skin (including reducing the amount lipid peroxides and/or protein oxidation in the skin). In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In certain embodiments, compositions of the present invention can decrease the amount of internal oxidation and/or external oxidative damage in a cell. In other aspects, the compositions can increase collagen synthesis in a cell. The compositions can also reduce skin inflammation, such as by reducing inflammatory cytokine production in a cell. Non-limiting examples of such cells include human epidermal keratinocyte, human fibroblast dermal cell, human melanocytes, three dimensional human cell-derived in vitro tissue equivalents comprising human keratinocytes, human fibroblasts, or human melanocytes, or any combination thereof (e.g., combination of human keratinocytes and human fibroblasts or a combination of human keratinocytes and human melanocytes).

Also disclosed is a method of treating hyperpigmentation comprising applying the compositions of the present invention to the skin. The method can also comprise identifying a person in need of treating hyperpigmentation and applying the composition to a portion of the skin exhibiting hyperpigmentation. Additional methods contemplated by the inventors include methods for reducing the appearance of an age spot, a skin discoloration, or a freckle, reducing or preventing the appearance of fine lines or wrinkles in skin, or increasing the firmness of skin by applying the compositions of the present invention to skin in need of such treatment.

In yet another aspect of the present invention there is disclosed a method of treating or preventing a wide variety of diseases comprising administering to a patient in need of treatment a composition comprisingNymphaea giganteaextract,Syzygium mooreiextract,Cupaniopsis anacardioidesextract,Archidendron hendersoniiextract,Tristaniopsis laurinaextract,Brachychiton acerifoliusextract,Stenocarpus sinuatusextract,Alphitonia excelsaextract,Eucalyptus coolabahextract,Plumeria albaextract,Cocos nuciferaextract, and/orTamarindus indicaextract, or any combination of said extracts (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11 of the aforementioned extracts), or all of said extracts. The composition can be formulated as a topical composition, an ingestible composition, an injectible composition, an aerosolized composition, etc. Non-limiting examples of diseases that can be treated or prevented with such compositions include AIDS, autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis, diabetes—insulin-dependent and non-independent, systemic lupus erythematosus and Graves disease), cancer (e.g., malignant, benign, metastatic, precancer), cardiovascular diseases (e.g., heart disease or coronary artery disease, stroke—ischemic and hemorrhagic, and rheumatic heart disease), diseases of the nervous system, and infection by pathogenic microorganisms (e.g., Athlete's Foot, Chickenpox, Common cold, Diarrheal diseases, Flu, Genital herpes, Malaria, Meningitis, Pneumonia, Sinusitis, Skin diseases, Strep throat, Tuberculosis, Urinary tract infections, Vaginal infections, Viral hepatitis), inflammation (e.g., allergy, asthma), prion diseases (e.g., CJD, kuru, GSS, FFI), obesity, etc. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In certain aspects, there is disclosed an aqueous extract ofNymphaea giganteaextract,Syzygium mooreiextract,Cupaniopsis anacardioidesextract,Archidendron hendersoniiextract,Tristaniopsis laurinaextract,Brachychiton acerifoliusextract,Stenocarpus sinuatusextract,Alphitonia excelsaextract,Eucalyptus coolabahextract,Plumeria albaextract,Cocos nuciferaextract, and/orTamarindus indicaextract or any combination thereof. The aqueous extract can include butylene glycol. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

Also disclosed is a composition comprising an extract of an extract ofNymphaea giganteaextract,Syzygium mooreiextract,Cupaniopsis anacardioidesextract,Archidendron hendersoniiextract,Tristaniopsis laurinaextract,Brachychiton acerifoliusextract,Stenocarpus sinuatusextract,Alphitonia excelsaextract,Eucalyptus coolabahextract,Plumeria albaextract,Cocos nuciferaextract, and/orTamarindus indicaextract, or any combination thereof. The composition can be an edible composition. The composition can take the form of a pill, liquid gel cap, or tablet. The composition can be an injectable solution (e.g., for intravenous delivery). The composition can be in the form of a neutraceutical. The extract can be an aqueous extract. The aqueous extract can include butylene glycol. In particular embodiments, the extract isNymphaea giganteaflower,Syzygium mooreileaf,Cupaniopsis anacardioidesleaf,Archidendron hendersoniiflower,Tristaniopsis laurinaleaf,Brachychiton acerifoliusleaf,Stenocarpus sinuatusleaf,Alphitonia excelsaleaf,Eucalyptus coolabahleaf,Plumeria albaflower,Cocos nuciferamilk, orTamarindus indicaleaf extract, or a combination thereof. The extract can be an aqueous extract. The solvent used to obtain the extract can include butylene glycol.

In a further aspect, there is disclosed a blend ofCupaniopsis anacardiodesleaf,Syzygium mooreiileaf, andArchidendron hendersoniiflower extracts. The extracts can each be aqueous extracts. Such aqueous extracts can include butylene glycol. The blend can be placed into any one of the compositions disclosed throughout this specification and can be used in any one of the methods disclosed throughout this specification.

In still another aspect, there is disclosed a blend ofNymphaea giganteaflower,Tristaniopsis laurinaleaf, andEucalyptus coolabahleaf extracts. The extracts can each be aqueous extracts. Such aqueous extracts can include butylene glycol. The blend can be placed into any one of the compositions disclosed throughout this specification and can be used in any one of the methods disclosed throughout this specification.

In yet another embodiment there is disclosed a blend ofPlumeria albaflower,Cocos nuciferamilk, andTamarindus indicialeaf extracts. The extracts can each be aqueous extracts. Such aqueous extracts can include butylene glycol. The blend can be placed into any one of the compositions disclosed throughout this specification and can be used in any one of the methods disclosed throughout this specification.

A further aspect includes a blend ofBrachychiton acerifoliusleaf,Stenocarpus sinuatusleaf, andAlphitonia excelsaleaf extracts. The extracts can each be aqueous extracts. Such aqueous extracts can include butylene glycol. The blend can be placed into any one of the compositions disclosed throughout this specification and can be used in any one of the methods disclosed throughout this specification.

Kits that include the compositions of the present invention are also contemplated. In certain embodiments, the composition is comprised in a container. The container can be a bottle, dispenser, or package. The container can dispense a pre-determined amount of the composition. In certain aspects, the compositions is dispensed in a spray, dollop, or liquid. The container can include indicia on its surface. The indicia can be a word, an abbreviation, a picture, or a symbol.

Also contemplated is a product comprising a composition of the present invention. In non-limiting aspects, the product can be a cosmetic product. The cosmetic product can be those described in other sections of this specification or those known to a person of skill in the art. Non-limiting examples of products include a moisturizer, a cream, a lotion, a skin softener, a foundation, a night cream, a lipstick, a cleanser, a toner, a sunscreen, a mask, an anti-aging product, a deodorant, an antiperspirant, a perfume, a cologne, etc.

It is also contemplated that compositions of the present invention can be included into food-based products (e.g., beverages, fortified water, energy drinks, nutritional drinks, solid foods, vitamins, supplements, etc.) and pharmaceutical products (e.g., pills, tablets, gel capsules, injectible solutions, drugs, etc.). “Supplements” can include vitamins, minerals, herbs or other botanicals, amino acids, enzymes and metabolites. Such supplements are suitable for oral consumption and can be administered orally.

It is contemplated that any embodiment discussed in this specification can be implemented with respect to any method or composition of the invention, and vice versa. Furthermore, compositions of the invention can be used to achieve methods of the invention.

In one embodiment, the topical skin compositions of the current invention are pharmaceutically elegant. “Pharmaceutically elegant” describes a composition that has particular tactile properties which feel pleasant on the skin (e.g., compositions that are not too watery or greasy, compositions that have a silky texture, compositions that are non-tacky or sticky, etc.). Pharmaceutically elegant can also relate to the creaminess or lubricity properties of the composition or to the moisture retaining properties of the composition.

“Keratinous tissue” includes keratin-containing layers disposed as the outermost protective covering of mammals and includes, but is not limited to, skin, hair and nails.

“Topical application” means to apply or spread a composition onto the surface of keratinous tissue. “Topical skin composition” includes compositions suitable for topical application on keratinous tissue. Such compositions are typically dermatologically-acceptable in that they do not have undue toxicity, incompatibility, instability, allergic response, and the like, when applied to skin. Topical skin care compositions of the present invention can have a selected viscosity to avoid significant dripping or pooling after application to skin.

The term “about” or “approximately” are defined as being close to as understood by one of ordinary skill in the art, and in one non-limiting embodiment the terms are defined to be within 10%, preferably within 5%, more preferably within 1%, and most preferably within 0.5%.

The terms “inhibiting” or “reducing” or any variation of these terms, when used in the claims and/or the specification includes any measurable decrease or complete inhibition to achieve a desired result.

The term “effective,” as that term is used in the specification and/or claims, means adequate to accomplish a desired, expected, or intended result.

The use of the word “a” or “an” when used in conjunction with the term “comprising” in the claims and/or the specification may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.”

The use of the term “or” in the claims is used to mean “and/or” unless explicitly indicated to refer to alternatives only or the alternatives are mutually exclusive, although the disclosure supports a definition that refers to only alternatives and “and/or.”

The words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”) or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps.

Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the examples, while indicating specific embodiments of the invention, are given by way of illustration only. Additionally, it is contemplated that changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

