TECHNICAL FIELD

The present invention relates to a pharmaceutical composition and method for use in improving quality of scalp or skin, wound healing, or improving quality of hair.

BACKGROUND ART

It is disclosed that the adipose-derived stem cell secretion extracted from adipose stem cells has an action stimulating hair matrix cells and a hair increasing effect (Non Patent Literature 1). In addition, hair increasing agents by suppressing male hormone have also been developed. However, although these treatments have a hair increasing effect during the treatment period, the hair increasing effect disappears when the treatment is ended.

CITATION LIST

Non Patent Literature

[Non Patent Literature 1] Byung-Soon Park et al., Biomedical Research, 31(1): 27-34, 2010

SUMMARY OF INVENTION

The present inventors have found that, when the secretion from adipose stem cells (hereinafter referred to as “ASC-CM”) is administered to the skin at a specific dose, it promotes skin regeneration, promotes skin modification, can heal skin wounds or promotes skin rejuvenation. The inventors have also found that, when ASC-CM is administered at a specific dose to the scalp, it promotes the regeneration of the scalp, promotes the modification of the scalp, or promotes the rejuvenation of the scalp. Furthermore, the present inventors have found that, when ASC-CM is administered at a specific dose to the scalp, it promotes hair modification (modification of cuticles, amelioration of gray hair, increase in hair growth rate, increase in hair thickness, etc.).

According to the present invention, the following invention is provided.

(1) A pharmaceutical composition for topical administration, for use in modifying scalp or skin, comprising a secretion from adipose stem cells as an active ingredient, wherein 0.3 to 0.6 μg of the secretion is administered in terms of protein abundance per site in scalp or skin.

(2) A pharmaceutical composition for topical administration, for use in treating a wound, comprising a secretion from adipose stem cells as an active ingredient, wherein 0.3 to 0.6 μg of the secretion is administered in terms of protein abundance per site in wound.

(3) A pharmaceutical composition for topical administration for use in modifying hair, comprising a secretion from adipose stem cells as an active ingredient, wherein 0.3 to 0.6 μg of the secretion is administered in terms of protein abundance per site in scalp or skin.

(4) The pharmaceutical composition according to (3), wherein the hair modification is reduction of gray hair.

(5) The pharmaceutical composition according to (3), wherein the hair modification is amelioration of roughness of hair cuticles.

(6) The pharmaceutical composition according to (3), wherein the hair modification is amelioration of hair thickness or growth rate.

(7) The pharmaceutical composition according to any one of (1) to (6), which is administered at a rate of 1 site per 1 cm2to 4 cm2of a surface of scalp or skin.

(8) The pharmaceutical composition according to any one of (1) to (7), which is administered in a solution volume of 10 to 30 μL per site.

(9) The pharmaceutical composition according to any one of (1) to (8), wherein the administration interval is from twice a month to once every 6 months.

According to the present invention, it is advantageous in that it provides a pharmaceutical composition or a treatment method that may exert effects continuously even after the end of treatment.

