FIELD OF TECHNOLOGY

The present technology generally relates to compositions comprising cannabinoids for relieving pain in a subject and to methods of using such compositions for relieving pain in a subject.

BACKGROUND INFORMATION

Natural or synthetic cannabinoid receptor agonists have been shown to be of therapeutic value for a number of important medical conditions, including pain (e.g., against pain of neuropathic origin), anxiety, glaucoma, nausea, emesis, muscle spasms, and wasting diseases. Insofar as pain is concerned, it is known that cannabinoid receptor agonists have antinociceptive and anti-hyperalgesic effects at the peripheral and central (spinal and supraspinal) levels, as has been demonstrated in acute and chronic pain models.

Cannabinoid receptors and endocannabinoids are present in pain circuits from the peripheral sensory nerve endings up to the brain. Cannabinoid receptor agonists modulate nociceptive thresholds by regulating neuronal activity, but they also relieve pain by acting on non-nervous tissues. CB1receptor is involved in the attenuation of synaptic transmission, and a proportion of the peripheral analgesic effect of endocannabinoids can be attributed to a neuronal mechanism acting through CB1receptors expressed by primary afferent neurons. Although CB2receptors have been related traditionally to the peripheral effects of cannabinoids (mainly modulation of the immunologic responses), they also contribute to antinociception by inhibiting the release of proinflammatory factors by non-neuronal cells located near nociceptive neuron terminals. CB2receptors are expressed in several types of inflammatory cells and immunocompetent cells. For that reason, activation of peripheral CB2receptors generates an antinociceptive response in situations of inflammatory hyperalgesia and neuropathic pain.

The use of cannabinoids to alleviate pain has been proposed and tested. However, there remain many challenges associated with achieving therapeutic effectiveness of cannabinoid agonist-based medications in the management of various types of pain. There also remain many challenges with providing adequate and reproducible dosages of cannabinoids which are efficient in the management of pain.

SUMMARY OF TECHNOLOGY

According to various aspects, the present disclosure provides for compositions for topical application comprising. The compositions comprise at least one cannabinoid; and at least one anti-inflammatory agent. Optionally, the composition comprises at least one botanical extract.

According to various aspects, the present disclosure provides for methods for relieving pain in a subject, the method comprising administering to the subject the compositions as defined herein.

Other aspects and features of the present disclosure will become apparent to those ordinarily skilled in the art upon review of the following description of specific embodiments.

