FIELD OF THE INVENTION

The invention relates to inter alia a healthcare product package, an information unit for a healthcare product and a method for forming a healthcare product package.

BACKGROUND OF THE INVENTION

It is known to provide healthcare products with an information article which contains informational content on the healthcare product. The informational article is typically located in the container (e.g. carton or box) along with the healthcare product. Examples of such healthcare products are pharmaceutical products, for instance blister packs with tablets, pills or the like, and the associated information article is a patient information leaflet (PIL).

For some healthcare products, it may be necessary to locate more than one information article into the container.

Regardless, hitherto the information articles have been provided loose into the container. Problems can arise in locating (e.g. inserting) and removing the loose information article from the container. Moreover, manufacturing complexities can exist for locating the loose information article into the container.

As background art there may be mentioned GB2213428A, US5127676, GB2290752A, US2001/002753A, EP1215127A, EP1237137A, US6749229, U.S. Pat. No. 6,712,398, WO2008/142434A, GB2483680A, WO2014/013441A, US2014/0059906A, U.S. Pat. Nos. 3,076,541, 5,263,743, 5,458,374, 6,270,121, WO2002/04313A, GB2504467A and WO2011/141870A. Additional background art is the Piggyback™ leaflet system available from Essentra Packaging in which two or three folded leaflets are formed separately then glued together in back-to-back arrangement (http://healthcare.essentrapackaging.com/en/products/leaflets/piggyback).

As further background art there may be mentioned US2015/287343A, U.S. Pat. No. 6,415,916, US2003/121810A, EP0246840A, WO2009/127736A, and US2011/192751A.

An aim of the invention is to provide an improved way for locating an information article in a healthcare product package.

SUMMARY OF THE INVENTION

According to a first aspect of the invention there is provided a healthcare product package comprising:

(a) a container for containing a healthcare product, and

(b) an information unit which is located inside the container,

wherein the information unit comprises a carrier and at least one information article attached to the carrier.

According to a second aspect of the invention there is provided an information unit adapted for association with a healthcare product, the information unit comprising a carrier and, attached thereto, at least one information article containing information about the healthcare product. The information unit may be adapted for location inside a container for the healthcare product, e.g. a carton or box. Preferably, the at least one information article is for the patient (e.g. a Patient Information Leaflet (PIL)/Package Insert), or for a healthcare professional (e.g. a Doctor's information leaflet (DIL)), or is an instruction for use (IFU), each concerning the healthcare product.

According to a third aspect of the invention there is provided a method for forming a healthcare product package comprising taking an information unit according to the second aspect of the invention, taking a healthcare product with which the at least one information article of the information unit contains information on, and locating the information unit and the healthcare product in a container. The information unit and the healthcare product may be located in the container simultaneously or sequentially. The former will be the case where the information unit includes the healthcare product, as described hereinbelow. The latter may involve the information unit being located prior to or after location of the healthcare product in the container. The location of the information unit and/or healthcare product in the container may be by insertion into the container (e.g. through an opening in the container), or by forming the container about the information unit and/or healthcare product.

Preferably, the carrier is in the form of a substrate (i.e. is a carrier substrate), for example a base card or backing card, as in the illustrated embodiments herein.

Information Unit

The use of the information unit makes it easier for the manufacturer to locate (e.g. insert) the at least one information article in the container. For example, hitherto the information article(s) itself had to be manipulated into the container. This can be awkward, especially when there are plural information articles to go into the container and/or when the information article(s) is of paper or a paper-like material. In the invention, however, the information article(s) can be located in the container more easily and quickly through use of the carrier, especially when using automated manufacturing apparatus (e.g. feeders, chutes, etc.) to manipulate and manoeuvre the information unit through (e.g. gripping of) the carrier. Another advantage is a reduction in the manufacturing equipment needed, especially if the carrier carries a plurality of information articles. Instead of using one feeder per information article, as is current practice, only one feeder would be needed for feeding the information unit (including the information article(s) carried thereon) into the container.

If an information article(s) is located loose in the container, as in the state of the art, it can be difficult or troublesome for a user to remove the information article(s), particularly when the information article(s) gets jammed or trapped in the container. In preferred embodiments of the invention, the information unit (i.e. with its information article(s)) is removable from the container. This makes it easier to remove the information article(s) from the container through the user grasping (e.g. pulling on) the carrier. To this end, the carrier is preferably located in the container so as to lie adjacent to an opening of the container. For instance, in the embodiments in which the carrier is a carrier substrate (e.g. base card/backing card), an end of the carrier substrate is located adjacent the opening. This may be achieved by using the carrier substrate to ‘stand’ the information unit in the container.

In embodiments, the healthcare product package is configured and arranged such that (i) an edge of the carrier is located in proximity to a container opening and (ii) the carrier is unable to move in the container to place the carrier edge remote from the container opening. This may be achieved by appropriate selection of the dimensions of the carrier relative to the dimensions of the container to maintain the spatial relationship between the container and the information unit so that the carrier may always be located proximate the opening of the container for a user to grasp hold thereof for removing the information unit from the container. As an example, the carrier dimensions relative to those of the container are selected such that the carrier is unable to rotate in the container. In embodiments, the carrier and container may each have a major dimension and a minor dimension, wherein the major dimension of each is greater than the respective minor dimension and wherein the carrier major dimension is larger than the container minor dimension, but smaller than the container major dimension. This facilitates insertion of the carrier into the container, but prevents rotation of the carrier within the container, thus ensuring that the information unit remains in the orientation of insertion, i.e. as it was inserted in the container, or when the container was formed about it.

In embodiments, the carrier has a rectangular plan form (footprint), and the container has a rectangular plan form, and the length of the carrier is greater than the width of the container, and the length of the carrier is less than the length of the container. Preferably, the length of the carrier is at least 90% of that of the container. This means the edge of the carrier is always available near to the opening of the container, but there is enough free movement to allow automatic closing of the container.

In embodiments, the container and carrier have footprints of the same general shape, but the carrier footprint size is less than that of the container footprint. Preferably, the footprint sizes are within 90% of one another.

In embodiments of the invention, the relative dimensions of the carrier and the container are such that the carrier is able to pass through an opening of the container to a rest position in which a carrier edge is located inside the container, but proximate the container opening. As an example, the carrier may have first and second ends, one of which rests against the internal surface of the container in the rest position and the other of which is inside the container, but proximate the container opening.

To enable the at least one information article to be easily read after the information unit has been removed from the container, it is preferable that the at least one information article is separable from the carrier, for instance by being releasably attached to the carrier. In embodiments of the invention, the at least one information article is secured to the carrier by a temporary adhesive, for example a peelable glue. The temporary adhesive may be applied as one or more spots. The skilled reader will readily conceive of other ways to achieve the releasable attachment.

In embodiments, the information unit is the solitary information unit in the container.

In other embodiments, the information unit is a first information unit and at least one further information unit is located within the container. The further information unit may comprise the same information article(s) as the first information unit (e.g., useful if the container is to contain a plurality of the same healthcare product, as described hereinbelow) or carry at least one different information article (e.g. useful if the container is to contain different healthcare products therein as each healthcare product then has its own associated information unit; i.e. the information article(s) of one/each information unit contains information about a different one of the healthcare products than the information article(s) of another/each other information unit).

As the container may contain a plurality of information units, statements herein about an information unit are applicable to each information unit in the invention.

Preferably, the information unit is freely located in the container (i.e. not physically attached to the container), as in the illustrated embodiments. Preferably, the information unit is wholly enclosed within the container, as in the illustrated embodiments.

Typically, the information unit consists only of the carrier and the information articles as component parts.

Preferably, as in the illustrated embodiments, the information unit does not include means for enclosing, in whole or in part, the information articles, such as an oversheet or overlaminate.

The information unit may be as described in any of the embodiments described hereinafter with reference to the accompanying FIGURES of drawings.

Carrier

Preferably, the carrier is in the form of a sheet, more preferably a planar sheet, having opposing major (e.g. top and bottom) surfaces, and the at least one information article is mounted on and attached to one (e.g. the top) major surfaces. A sheet-form carrier minimises the amount of material used for the carrier, and also the container which would otherwise have to be larger, and hence costs. Preferably, the carrier is a sheet-form base card/backing card, as in the illustrated embodiments.

The carrier may be made from paper, card, plastic or a mixture (e.g. laminate) thereof. The carrier will typically be of a board material (for instance, paperboard, fibre-board or cardboard) and/or of a laminate (e.g. multi-ply) construction.

Preferably, the carrier has a square or rectangular shape (i.e. has superimposed top and bottom sides/faces which are both square or both rectangular (as in the illustrated embodiments of the invention hereinafter disclosed)). In embodiments, the carrier has a rectangular shape with an aspect ratio (length to width) of at least 1.5:1, preferably in the range of 1.5:1 to 3:1.

Preferably, as in the illustrated embodiments, the carrier is larger than credit-card size; for example, the carrier has a maximum dimension which is greater than 90 mm, and more preferably at least 100 mm.

In embodiments, the length of the carrier is in the range of 100-200 mm.

In embodiments, the width of the carrier is in the range of 50-80 mm.

In embodiments, such as the illustrated embodiments, the carrier is thin, for example has a thickness in the range of 0.1-2 mm.

Each of the illustrated embodiments may be made to satisfy the dimensional ranges mentioned hereinabove.

It will be appreciated that other shapes and dimensional ranges for the carrier, besides those stated above, may be used without departing from the scope of the invention.

Preferably, the carrier has an appropriate (e.g. stiff) construction, e.g. to enable it to be inserted into the container with the at least one information article (and the healthcare product(s) thereon, if provided thereon, as described infra), especially manipulation and insertion by automated production line machinery, such as leaflet feeders, pusher arms, chutes, cams, pick-and-place robotic arms, etc. Conveniently, the carrier is made from a material having a stiffness which is similar to that provided by paperboard.

In embodiments, such as those shown inFIGS. 1 to 9hereinafter to be described, the carrier is a single, rigid piece of sheet material.

In embodiments, such as those shown inFIGS. 1 to 9hereinafter to be described, the carrier is provided with no special means that would enable the carrier to change the size of its footprint, e.g. to be (un)folded (i.e. no folding lines), excluding any provided for an optional peripheral wing or wings.

Preferably, as in the illustrated embodiments, the carrier is not an adhesive label nor a container (e.g. blister pack). Preferably, as in the illustrated embodiments, the carrier does not have any means for attaching itself to the container (only for securing the information article(s) and, optionally, also healthcare product(s) thereto). Preferably, as in the illustrated embodiments, the side/face of the carrier opposite to that which carries the information article(s) is not provided with adhesive or other attachment means for attaching the carrier to another object (e.g. the container).

In accordance with the present invention (i.e. in all of its different aspects), the carrier may be in a collapsed state and be movable to an extended state (a so-called ‘extendible carrier’). The collapsed state is the (compact) form that the extendible carrier is in when it is in (and being located in) the container of the related healthcare product. After the extendible carrier is removed from the container it is able to be extended to its extended state. The extendible carrier may be extended with all or some of the one or more information articles either (i) still being attached thereto, or (ii) having been detached therefrom.

Preferably, the extendible carrier is comprised of at least two panels of which at least one is movable relative to the other to move between the collapsed and extended states. Conveniently, the carrier may consist or substantially consist of the panels. Conveniently, the carrier panels may be of the same, or substantially the same, shape and size. Preferably, in the collapsed state of the carrier the carrier panels locate in an overlying (stack) arrangement, more preferably an overlying arrangement in which the panels are co-extensive or substantially co-extensive.

Preferably, the collapsed state of the carrier is an overlying arrangement of (optionally all of) the carrier panels.

Typically, the extendible carrier will carry the at least one information article on an outer surface thereof when in the collapsed state. Alternatively, the at least one information article may be carried inside the extendible carrier when in its collapsed state, e.g. sandwiched between opposing facing surfaces of the carrier panels in the collapsed state.

Preferably, the footprint of the carrier in its collapsed state is the same or substantially the same as the footprint of the largest panel of the carrier.

Preferably, the carrier is able to extend to an extended state which is a sheet form, more preferably a planar sheet form (i.e. a generally two dimensional (i.e. flat) form; small thickness).

Preferably, the collapsed and extended states are respectively folded and unfolded states of the carrier. As an example, the carrier may have one or more fold lines to define a plurality of carrier panels which can be folded about the fold lines between it and an adjacent carrier panel. Conveniently, if there are a plurality of fold lines, all fold lines are parallel or substantially parallel to one another. Alternatively, there may be fold lines arranged perpendicularly to each other, optionally intersecting each other. In simple forms, the fold lines may be arranged as follows:a single fold line to divide (e.g. bisect) the carrier into two carrier panels;plural fold lines, all parallel or substantially parallel to one another, so that the carrier is divided into a row of at least three consecutive carrier panels (i.e. X+1 panels, where X is the number of fold lines) thereby creating a carrier of concertina form; ora pair of intersecting fold lines arranged perpendicularly or substantially perpendicularly to each other so as to divide the carrier into four carrier panels (quarters).

Preferably, the fold lines are arranged so that the carrier panels are foldable to overlie each other in the folded state. More preferably, in the folded state the carrier panels are stacked to be co-extensive or substantially co-extensive with one another.

Preferably, the fold lines are arranged so that all of carrier panels are of the same shape and size. This is particularly useful where the co-extensive stack arrangement mentioned in the paragraph above is required.

Preferably, the shape and size of the carrier in its collapsed (e.g. folded) state corresponds to or substantially corresponds to the shape and size of one (and optionally all) of the carrier panels.

An advantage of the extendible carrier is that its outer surface area is increased by moving from the collapsed state to the extended state. Consider, some of the outer surface area of the carrier in its extended state forms some or all of the internal surface area of the carrier in its collapsed state.

Accordingly, the extendible carrier is able to present a greater outer surface area when in its extended state than a carrier (e.g. a non-extendible carrier, such as those inFIGS. 1 to 9hereinafter to be described) which presents a maximum outer surface area corresponding to the outer surface area of the extendible carrier when in its collapsed state. This means the extendible carrier can present more information on it than if it only had the outer surface area of its collapsed state (i.e. the size for its function to locate the at least one information article in the container). So, the extendible carrier provides an opportunity to have a carrier which not only fulfils its function to carry at least one information article and locate same in a container, but which can also function to carry extra information on it (e.g. concerning the related healthcare product). With this in mind, in a preferred embodiment the extendible carrier is provided with information on one or more surface areas of the carrier which are internal surface areas in the collapsed state, but outer surface areas in the extended state. This may or may not be additional to information provided on the outer surface area(s) of the carrier in both its collapsed and extended states. Where the carrier is comprised or consists of carrier panels, it is preferable that information is presented by more than one such carrier panel.

Preferably, the extendible carrier is a quickstart guide. A quickstart guide is a short, simple introductory guide created to get users quickly accustomed to the basic operations of something (which may comprise set-up guidance).

In the context of the present invention, a quickstart guide will typically concern the healthcare product or pharmaceutical product, and most typically the delivery device of such a product. In the latter case, the quickstart guide may be a guide to the basic operations of the delivery device.

Typically, the quickstart guide provides its guidance at least in part through use of pictorial representations, for instance ideograms.

Typically, the guidance provided by the quickstart guide will be information printed on the carrier.

Typically, the extendible carrier is made from a sheet-like structure (i.e. effectively a two dimensional (flat) structure), for example made of a board material, particularly for the foldable carrier in which the fold lines are formed in the sheet-like structure (so-called ‘blank’) by scoring, creasing or other means known in the packaging art.

In embodiments, the size of the carrier in its extended state prevents it from being able to be located in the container (or moved from the collapsed state to the extended state when located in the container). For example, the carrier in its extended state is unable to pass through an opening of the container for location in the container.

Preferably, the carrier has a footprint of a rectangular or square shape.

In the embodiments where the carrier is extendible, this carrier preferably has a footprint which is rectangular or square in either its collapsed state or extendible state, more preferably in both states.

In yet more preferred embodiments, the footprint shape of the carrier in its collapsed and extended states is the same.

Preferably, the extendible carrier is comprised of panels of a rectangular or square shape or a mixture of such shapes. Ideally, the panels of the carrier are of the same shape, and yet more preferably of the same size. Even more preferably, all panels are as stated in the preceding two sentences.

In embodiments, the extendible carrier in its collapsed state carries one or more accessories therewithin. The accessory will typically be related to the healthcare product; for instance one or more swabs for wiping a planned injection site on the skin of a living human or animal body where the healthcare product comprises a syringe or an (auto)injector.

The collapsed state may be maintained by a releasable attachment, for instance a temporary adhesive. Other forms of releasable attachment can be conceived of, including an integrally formed fastening feature of the carrier (e.g. an integrally formed fastening feature of a carrier blank).

The carrier may be as described in any of the embodiments of the invention described hereinafter with reference to the accompanying FIGURES of drawings.

Information Article(s)/Healthcare Product(s)

Typically, the information article(s) is made from paper or a paper-like material, as in the illustrated embodiments.

Typically, the information article or at least one (some or all) of the information articles provides information about the healthcare product. In embodiments, the container is for containing a solitary healthcare product. In other embodiments, the container is for containing a plurality of the healthcare products (i.e. each is the same). In yet other embodiments, the container is for containing another healthcare product which is different (e.g. a different type, different strength, etc.) and the information unit further comprises an information article for the different healthcare product.

The information on the healthcare product(s) may be user instructions, safety information or product specification/characteristics, etc.

The healthcare product(s) may be composed of at least first and second parts (e.g. a dispenser as the first part and one or more refills therefor as the second part) and the information unit comprises an information article for each said part.

Typically, as in the illustrated embodiments, the information is presented on the at least one information article in a form that is comprehensible to a human, preferably a viewable (e.g. readable) content, for instance in the form of text, figures, images and suchlike or mixtures thereof.

Any information article(s) carried on the carrier may be in a folded-up state, as in the illustrated embodiments of the invention disclosed hereinafter; methods for folding are known in the packaging art. If there a multiple information articles on the carrier, some or all of them may be folded-up.

Typically, the information article(s) for use in the invention is a printed information article, more typically a printed paper article.

Non-limiting examples of an information article for use in the invention are leaflets, labels, booklets, vouchers, coupons and the like. These may be printed and/or made of paper or a paper-like material.

Non-limiting examples of leaflets for use in the invention are plain leaflets (e.g. glued together), Glueserts, tagserts, wrapserts, etc., as is known in the packaging art.

In embodiments, the/each healthcare product or one of the healthcare products to be contained in the container is a pharmaceutical product and the information unit contains one or more information articles containing information about the pharmaceutical product and/or its characteristics. This information will typically be about the medicament in the pharmaceutical product, e.g. composition (e.g. the active substance(s) and (if any) other formulation components (e.g. excipients)), side effects, contraindications, dosage, etc. This information article may be a leaflet, more particularly a folded leaflet. An example of such an information article is called a ‘patient information leaflet’ (PIL) in Europe and a ‘package insert’ (formerly called ‘prescribing information’) in the United States of America (USA). Another example of such an information article is one for a healthcare professional (e.g. physician or clinician), for instance a Doctor's Information Leaflet (DIL)). In embodiments, the information unit comprises a PIL and a DIL.

The term “pharmaceutical product” herein means drug products, biopharmaceutical products, vaccine products or any other product containing one or more substances with properties for treating, preventing, palliating or diagnosing disease in human beings (including symptomatic treatment). The term “medicament” herein is to be understood having regard to this meaning of pharmaceutical product.

In embodiments, the pharmaceutical product comprises a delivery device for the medicament and the information unit comprises at least one information article containing information about the delivery device, for instance user/operation instructions, information about the device and its characteristics, etc. (known as “Instructions for Use”). Non-limiting examples of such a delivery device are a syringe, (auto)injector, inhaler, sprayer, patch, etc. The delivery device may be pre-loaded with a medicament dosage form (e.g. vial, ampoule, cartridge, capsule, tablet(s), inhalation powder, aerosol, etc.) and/or be for (re)use with separate medicament dosage forms which need to be loaded into the delivery device. Typically, such information article(s) for the delivery device will be in the form of a (folded) leaflet.

In preferred embodiments of the invention, such as those hereinafter described with reference to the drawings, the container is to contain a pharmaceutical product (or plural pharmaceutical products of the same type) and the package includes at least two information articles (e.g. two folded leaflets) containing information about the pharmaceutical product, for example information about the pharmaceutical product chosen from the group consisting of information about (i) the medicament, (ii) the delivery device for the medicament, and (iii) a refill for the delivery device. The at least two information articles may comprise at least one information article with information about the medicament (e.g. a PIL and/or a DIL) and an information article about the delivery device (e.g. Instructions for Use). The at least two information articles are preferable arranged as a stack on the carrier, as described hereinbelow.

In embodiments, the information unit has as information articles: a PIL, a DIL and Instructions for Use. Each may be a folded leaflet and/or arranged as a stack (infra).

The information article(s) may be as described in any of the embodiments described hereinafter with reference to the accompanying FIGURES of drawings.

Container

In embodiments, the container is closed with the information unit located therein.

The container is adapted to be opened to enable access to the contents in its inner space. Preferably, the container has a closable opening through which the information unit is adapted to be introduced (e.g. inserted) and/or removed from the container. Preferably, the opening, when closed, can be opened to enable the information unit to be removed from the container. The opening may be closed by at least one closure of the container. Preferably, the opening is common to the healthcare product, enabling its introduction into and/or removal from the container.

The opening may be re-opened after it is closed, e.g. to enable removal of the information unit and/or healthcare product. The opening may or may not be able to be re-closed, depending on the nature of the closure. If the opening is closed by a single-use closure, for example of the “tear-and-forget” type, re-closure of the opening is not possible.

The container may be a box or carton, for instance erected from a preform, such as a blank, for example by folding (e.g. a blank with fold- or score-lines to enable it to be erected into the container). Typically, the blank for the box or carton has one or more panels which define the at least one closure.

Alternatively, the container may be a book structure or a wallet structure. An example of a book or wallet structure is a structure having two parts joined at a hinge (or spine) so that the parts can be hinged between a closed position, in which the parts are overlying to define an inner space therebetween which contains the information article and for containing the healthcare product, and an open position, in which the parts are separated to enable removal of the information unit/healthcare product.

Typically, the container (regardless of type) will be of generally polygonal (e.g. rectangular or square) form. Moreover, the container (regardless of type) will typically be made of a board material (for example paperboard, fibre-board or cardboard) and/or formed from a preform, for example a blank (for example a one-piece blank) provided with appropriate fold- or score-lines to enable the blank to be erected into the container. Alternatively, the container may be made with a polymeric material or mixture of materials including a polymeric material.

Where the container is a box, for instance a carton, the container will comprise a number of walls (e.g. presented by panels) circumscribing the inner space of the box/carton, at least one opening to the inner space and at least one closure for each opening. The at least one closure may be in the form of one or more closure flaps, for instance one or more closure flaps which close-off and tuck into the opening, as known in the packaging art.

Typically, especially where the box/carton is of polygonal form, the box/carton will have a top panel, bottom panel and a plurality of side panels extending between the top and bottom panels (the number depending on the shape of the box/carton). One or more of these panels forms a closure to an opening to the inner volume of the container. Such panel(s) may be in the form of one or more closure flaps. An example of a carton of this type is described hereinbelow with reference toFIG. 10.

Preferably, the information unit and/or healthcare product would be introduced into the container by insertion thereinto through an opening of the container. However, other means of locating the information unit and/or healthcare product in the container may be envisaged within the scope of the invention; for example, forming the container around the information unit and/or healthcare product, particularly where the container is formed from a perform, e.g. a blank.

The container may be as described in any of the embodiments of the invention described hereinafter with reference to the accompanying FIGURES of drawings.

Healthcare Product

As indicated hereinabove, the healthcare product (to be) contained in the container may be a pharmaceutical product which optionally includes a delivery device for the medicament of the pharmaceutical product.

In embodiments of the invention, the container contains the healthcare product. The healthcare product may be (i) the solitary healthcare product in the container, or (ii) one of a plurality of the healthcare products (i.e. each is the same), or (iii) a first healthcare product with the container also containing a second, different healthcare product (e.g. of a different strength or a different type). In the latter case, the information unit preferably comprises an information article for each respective different healthcare product or the information unit has an information article about the first healthcare product and an additional information unit is located within the container and comprises an information article about the second healthcare product.

In embodiments, the healthcare product is mounted to the carrier. In this case, the healthcare product is located in the container by the information unit (i.e. because the healthcare product is mounted on the carrier, along with the information article(s), prior to the information unit being located in the container). The mounting may be so that the healthcare product is not attached to the carrier; i.e. it is freely movable/removable. Alternatively, the healthcare product may be fixed against movement (other than play) on the carrier; i.e. the healthcare product is attached (typically releasably) to the carrier. In embodiments, there are plural healthcare products mounted to the carrier in the container.

Typically, the or each healthcare product is mounted to the same side of the carrier as the at least one information article.

As the container may contain a plurality of healthcare products, statements herein about a healthcare product are applicable to each healthcare product.

In embodiments, the pharmaceutical product comprises an antigen binding protein that specifically binds to B Lymphocyte Stimulator (BlyS). The antigen binding protein may be an antibody or fragment thereof. The antigen binding protein may be a monoclonal antibody such as a chimeric, human or humanized antibody. The antigen binding protein may be comprised in a formulation for parenteral administration, examples being intravenous and sub-cutaneous administration. In embodiments, the BlyS binding antibody is belimumab.

In embodiments, the pharmaceutical product comprises a syringe or (auto)injector which is prefilled with a belimumab formulation or other formulation containing an antigen binding protein that specifically binds to BlyS.

The pharmaceutical product referred to in the preceding two paragraphs may be for treating a B-cell regulated autoimmune disorder, for example lupus, in particular systemic lupus erythematosus (SLE).

Plural Information Articles and Stacking

In embodiments where there are plural information articles in the information unit, the information articles are of the same type or are a mixture of different types. Typically, when there are plural information articles these are attached (e.g. releasably) to a common side of the carrier, either in a simple side-by-side arrangement on the common carrier side or in a stack arrangement, non-limiting examples of which are found in the illustrated embodiments of the invention hereinafter to follow.

A “stack” is created by building-up information articles (e.g. folded leaflets) on top of each other on the carrier thereby creating two or more levels of information articles. As an example, the stack has at least (i) a bottommost information article which is attached (e.g. releasably) to the common (top) side of the carrier, and (ii) a topmost information article which is attached (e.g. releasably) to the top side of an information article in the stack immediately behind it. In its simplest form, the stack consists only of these two information articles so that the topmost information article is attached to the bottommost information article. In other simple forms, the stack includes at least one intermediate information article sandwiched between the topmost and bottommost information articles. Each such intermediate information article is attached (e.g. releasably) to the information article in the stack immediately behind it (i.e. the bottommost information article or another intermediate information article, depending on if there is more than one intermediate information article) and supports the information article in the stack atop it (i.e. the topmost information article or another intermediate information article; again, depending on if there is more than one intermediate information article). By way of example, for the stack the information articles may be arranged relative to each other as in the Piggyback™ leaflet available from Essentra Packaging; here, two or three folded leaflets are formed separately then glued together in back-to-back arrangement (http://healthcare.essentrapackaging.com/en/products/leaflets/piggyback).

More complex stacks are also envisioned. For example, a stack in which there is more than one information article at the same level of the stack, whether that be at the bottommost level, the topmost level or an intermediate level. Moreover, a stack may include one or more branches in it. Such branches may or may not recombine at a level of the stack (i.e. an information article straddles or bridges across to some or all of the branches.

By “stacking” or “stacked” herein means arranging information articles on the carrier to form a stack or series of stacks on the carrier.

In embodiments, there is either a single stack on the carrier or there are plural independent stacks (i.e. none of the information articles in the respective stacks are shared with another stack).

The attachment between the information article(s) and the carrier and/or between respective information articles is preferably releasable so that the information articles can be separated from the carrier and/or each other. By way of example only, the releasable attachment may be through use of a temporary adhesive, for instance in the form of a peelable glue/adhesive. The temporary adhesive can be applied as one or more spots between the information article and the other element (carrier and/or other information article) it is to be releasably attached to.

The information articles may be arranged on the carrier as described in any of the embodiments described hereinafter with reference to the accompanying FIGURES of drawings.

Miscellaneous

Preferably, neither the carrier nor the information unit is attached to the container. No means for any such attachment are provided to the carrier, information unit or container. Thus, no special measures are needed to remove the information unit from the container, such as detaching or the like.

Preferably, the carrier does not comprise or form a blister structure (e.g. blister pack or blister tray) or any part thereof.

In embodiments, the healthcare product does not comprise an artificial tooth or component thereof.

Preferably, the information unit does not comprise any part of the container, e.g. any integrally formed part of the container, such as a panel or flap etc. thereof. In other words, the information unit and the container are formed wholly separately.

Further non-limiting embodiments of the various aspect of the invention are described hereinafter with reference to the accompanying FIGURES of drawings.

Each embodiment of the invention described herein may include one or more of the features of one or more of the other embodiments herein described.

