TECHNICAL FIELD

The present invention relates to an anti-inflammatory composition, and more particularly, to an anti-inflammatory pharmaceutical composition and an anti-inflammatory cosmetic composition having an anti-inflammatory effect by controlling an expression of an inflammatory skin disease-related mediating factor.

BACKGROUND ART

Inflammation is one of the defense reactions of a living body to prevent damage to living tissue due to an increase of blood flow of an infected area, swelling, immune cells and antibody migration, pain, fever, and the like, caused when histamine, kinin, and the like, are released by cell damage caused by external biologic causes (bacteria, viruses, and parasites), physiological causes (mechanical stimulation, heat, radiation, and electricity), chemical causes, and the like, thus resulting in vasodilation, an increase in capillary permeability, and accumulation of macrophages at inflammatory sites.

An inflammatory skin disease generally refers to eczematous dermatitis. The eczema refers to a skin disease in which vesicles (small blisters) with itching, erythema (reddening of the skin), swelling, and the like, are seen in the acute phase, while lichniscation (indicating that lines of skin that are normally present on the skin such as palms become clearer due to dry and firm skin), scale, changes in skin color, and the like, are seen while decreasing the swelling and the vesicle in the chronic phase. Examples of the eczematous dermatitis may include contact dermatitis, atopic dermatitis, and seborrheic dermatitis, and the like.

As described above, the inflammatory response in the skin starts as an action to defend skin damage caused by physical stimulation, chemical substances, bacteria, and the like, and various immune cells and inflammation-inducing cytokines are involved therein. Representative examples of the cytokine may include interleukin, a proliferation factor, chemokine, a tumor necrosis factor, interferon, and the like. Specific examples of the cytokine may include insulin, insulin growth factor (IGF)-I, IGF-II, epidermal growth factor (EGF), transforming growth factor (TGF)-α, TGF-β1, TGF-β2, fibroblast growth factor (FGF)-1, FGF-2, FGF-3, FGF-4, FGF-5, FGF-6, FGF-7, FGF-8, FGF-9, FGF-10, FGF-11, FGF-12, FGF-13, FGF-14, FGF-15, FGF-16, FGF-17, FGF-18, FGF-19, vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, VEGF-D, nerve growth factor (NGF), interleukin (IL)-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, granulocyte macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), macrophage colony stimulating factor (M-CSF), stem cell factor (SCF), flt-3 ligand (FL), angiopoietin, erythropoietin (EPO), thrombopoietin (TPO), oncostatin M (OSM), leukemia inhibitory factor (LIF), activin, inhibin, bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), tumor necrosis factor (TNF)-α, TNF-β, Fas ligand (Fas-L), CD40 ligand, macrophage inflammatory protein (MIP), monocyte chemoattractant protein (MCP), interferon (IFN)α, IFNβ, IFNγ, glial cell-derived neurotrophic factor (GDNF), angiotensin, and the like.

Currently, synthetic medicines such as ibuprofen, antihistamines, steroids, cortisone, immunosuppressants, immune promoter, and the like, are used for prevention and treatment of inflammatory skin diseases. However, the treatment effect is temporary, there are many side effects such as simple symptom relief, hypersensitivity reaction, aggravation of the immune system, and the like, and there are limitations on the fundamental treatment of inflammation. In addition, Korean Patent No. 0563548, Korean Patent No. 0697319, Korean Patent No. 1309172 and Korean Patent No. 1141802 disclose various attempts to develop a cosmetic composition having an anti-inflammatory function using a natural extract. However, the use amount of the composition is limited due to another skin irritation, discoloration, or the like, or solubility in water is not good, and thus it is difficult to obtain a substantial effect due to limitation of application when the composition is applied to an actual product.

Thus, the present applicant conducted intensive studies on degree of activity inhibition of inflammation-inducing cytokine which is an inflammatory skin disease-related mediating factor, and as a result, found that a compound derived from specific alcohol or amino acid is not only safe on the skin because the compound has no cytotoxicity, allergenicity, and the like, but also because the compound effectively functions to inhibit production of inflammation-inducing cytokines (particularly, IL-8 and IL-17), and completed the present invention by providing an anti-inflammatory composition including the same.

DISCLOSURE

Technical Problem

An object of the present invention is to provide an anti-inflammatory composition capable of effectively inhibiting skin inflammation and having an excellent skin cell regeneration effect without causing skin side effects.

Technical Solution

In one general aspect, an anti-inflammatory composition includes: a compound represented by Chemical Formula 1 below as an active ingredient:



in Chemical Formula 1,

R1is hydrogen, (C1-C30)alkyl, (C2-C30)alkenyl, (C2-C30)alkynyl, (C1-C30)alkoxy, or hydroxy(C1-C30)alkyl;

R2is (C1-C30)alkyl, (C2-C30)alkenyl, (C2-C30)alkynyl, (C1-C30)alkoxy, or hydroxy(C1-C30)alkyl; and

R3is


or a substituted or unsubstituted amino acid group, wherein R11is hydroxy(C1-C30)alkyl.

The anti-inflammatory composition according to an embodiment of the present invention may include the above-described compound as an active ingredient to control cytokine and inhibit expression of an inflammation mediating molecule, thereby controlling stimulation and inflammation. In detail, the anti-inflammatory composition according to the present invention has excellent inhibitory effects, particularly, on inflammation-inducing cytokines such as interleukin-8 (IL-8), interleukin-17 (IL-17), and the like.

In other words, the anti-inflammatory composition according to an embodiment of the present invention may increase distribution of a regulatory T cell (Treg) that inhibits an activity of inflammatory cells such as macrophages or neutrophils, thereby effectively inhibiting expression of inflammation to exhibit an excellent anti-inflammatory effect.

The anti-inflammatory composition according to the present invention may be formulated into a pharmaceutical composition or a cosmetic composition including the compound represented by Chemical Formula 1 above as an active ingredient, and the composition has an excellent effect in improving inflammatory skin diseases, particularly, atopic dermatitis and/or allergic dermatitis.

Advantageous Effects

According to the present invention, the regulation of cytokine may be suppressed to effectively prevent the inflammatory reaction, and thus excellent anti-inflammatory effects on inflammatory skin diseases, particularly, atopic dermatitis, allergic dermatitis, and the like, may be exhibited.

Further, the anti-inflammatory composition containing the active ingredient according to the present invention may be safely applied to cosmetic compositions and pharmaceutical compositions of various formulations since the anti-inflammatory composition does not have cytotoxicity and skin side effects.

