@inproceedings{
nguyen2023causal,
title={Causal Inference in Gene Regulatory Networks with {GF}lowNet: Towards Scalability in Large Systems},
author={Trang Nguyen and Alexander Tong and Kanika Madan and Yoshua Bengio and Dianbo Liu},
booktitle={NeurIPS 2023 Generative AI and Biology (GenBio) Workshop},
year={2023},
url={https://openreview.net/forum?id=jbamDZ374t}
}
Understanding causal relationships within Gene Regulatory Networks (GRNs) is essential for unraveling the gene interactions in cellular processes. However, causal discovery in GRNs is a challenging problem for multiple reasons including the existence of cyclic feedback loops and uncertainty that yields diverse possible causal structures. Previous works in this area either ignore cyclic dynamics (assume acyclic structure) or struggle with scalability. We introduce Swift-DynGFN as a novel framework that enhances causal structure learning in GRNs while addressing scalability concerns. Specifically, Swift-DynGFN exploits gene-wise independence to boost parallelization and to lower computational cost. Experiments on real single-cell RNA velocity and synthetic GRN datasets showcase the advancement in learning causal structure in GRNs and scalability in larger systems.
Causal Discovery in Gene Regulatory Networks with GFlowNet: Towards Scalability in Large Systems
Trang Nguyen Alexander Tong Kanika Madan Yoshua Bengio Dianbo Liu