<story><title>Fasting Improves Physiological and Molecular Markers of Aging (2019)</title><url>https://www.cell.com/action/showPdf?pii=S1550-4131%2819%2930429-2</url></story><parent_chain><item><author>onlyrealcuzzo</author><text>Wait. Why is it possible fasting has upsides, but it is not possible it has downsides?</text></item><item><author>theNJR</author><text>I really urge people to do a multi-day fast a few times a year. I wrote a little guide about it that I shared previously [1].&lt;p&gt;You can wonder about these longterm positive effects, but it&amp;#x27;s sort of a Pascals wager. You lose absolutely nothing and it could have significant upside. Worst case, it makes you confront your relationship to food and offers a great mental challenge.&lt;p&gt;One cool thing that you learn is that there is a maximum hungry you get. It doesn&amp;#x27;t ever go past that point (and you&amp;#x27;ve felt it before without fasting). Even better, it ebbs and flows. You won&amp;#x27;t be in a state of &amp;quot;OMG I am starving!!&amp;quot; all day long. It hits at normal eating times, and then retreats to the background.&lt;p&gt;Anyway, just try it.&lt;p&gt;[1]&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nicholasjrobinson.com&amp;#x2F;blog&amp;#x2F;general&amp;#x2F;five-day-fasting-guide-freedom-from-food-people-and-technology&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nicholasjrobinson.com&amp;#x2F;blog&amp;#x2F;general&amp;#x2F;five-day-fast...&lt;/a&gt;</text></item></parent_chain><comment><author>arcticbull</author><text>You could ask the same question about eating 3-4 meals per day.&lt;p&gt;This is a relatively new phenomenon for humans - starting in the 1700s. Feast&amp;#x2F;famine is how we used to live. The Romans ate one meal a day and frowned upon breakfast, for instance - their default was what we would now consider OMAD fasting. [1]&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.bbc.com&amp;#x2F;news&amp;#x2F;magazine-20243692&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.bbc.com&amp;#x2F;news&amp;#x2F;magazine-20243692&lt;/a&gt;</text></comment>
<story><title>Fasting Improves Physiological and Molecular Markers of Aging (2019)</title><url>https://www.cell.com/action/showPdf?pii=S1550-4131%2819%2930429-2</url></story><parent_chain><item><author>onlyrealcuzzo</author><text>Wait. Why is it possible fasting has upsides, but it is not possible it has downsides?</text></item><item><author>theNJR</author><text>I really urge people to do a multi-day fast a few times a year. I wrote a little guide about it that I shared previously [1].&lt;p&gt;You can wonder about these longterm positive effects, but it&amp;#x27;s sort of a Pascals wager. You lose absolutely nothing and it could have significant upside. Worst case, it makes you confront your relationship to food and offers a great mental challenge.&lt;p&gt;One cool thing that you learn is that there is a maximum hungry you get. It doesn&amp;#x27;t ever go past that point (and you&amp;#x27;ve felt it before without fasting). Even better, it ebbs and flows. You won&amp;#x27;t be in a state of &amp;quot;OMG I am starving!!&amp;quot; all day long. It hits at normal eating times, and then retreats to the background.&lt;p&gt;Anyway, just try it.&lt;p&gt;[1]&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nicholasjrobinson.com&amp;#x2F;blog&amp;#x2F;general&amp;#x2F;five-day-fasting-guide-freedom-from-food-people-and-technology&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nicholasjrobinson.com&amp;#x2F;blog&amp;#x2F;general&amp;#x2F;five-day-fast...&lt;/a&gt;</text></item></parent_chain><comment><author>solarmist</author><text>Of course, it has downsides—the length of the fast matters a LOT. Too long, and it’s starvation which has considerable downsides as I’m sure you’re already aware.&lt;p&gt;The biggest takeaway that I’ve gotten recently is that our bodies are literally designed to take fasting into account. Specifically, our vascular system is terrible at doing cleanup and nutrient delivery at the same time. So it needs ample time to do both.</text></comment>