<story><title>Loss of myelin is one of the major factors of age-related brain deterioration</title><url>https://www.port.ac.uk/news-events-and-blogs/news/brains-wiring-insulation-is-one-of-the-major-factors-of-age-related-brain-deterioration</url></story><parent_chain><item><author>AnIdiotOnTheNet</author><text>&amp;gt; The doctors were completely dismissive of and uninterested in the symptoms -- it really shook my faith in medical practice.&lt;p&gt;I had a similar experience as a child, where a textbook case of a reasonably common disease went undiagnosed for 2 years by doctors before a toll booth worker at an airport diagnosed me. She recognized the symptoms because her dog had it. Sure enough, after my mother brow-beat a doctor into running the absurdly simple blood test she was proven right.&lt;p&gt;On the one hand, I want to chalk this up to them being like everyone else: 90% of them are just shit at their jobs. On the other hand, I have it on good authority from nearly every nurse I&amp;#x27;ve ever met that doctors are indeed arrogant, dismissive, and often mistaken.</text></item><item><author>ctrlp</author><text>I can attest. This happened to my wife 15+ years ago. The reaction began after two doses of Levaquin and was 3 months of non-stop living hell. Seriously painful neuropathy, burning all over her body. Profuse sweating all night. Brutal nightmares. Brain fog. Crippling pain in her appendages, melting walls. Extremely distressing.&lt;p&gt;The doctors were completely dismissive of and uninterested in the symptoms -- it really shook my faith in medical practice. We were on an oddessey to determine what was wrong and could be done to help. It took her 6 months to resume walking more than a short distance. She still has foot and hand problems from permanent neuropathy that affect her daily.&lt;p&gt;A few years after, Levaquin was black-labelled, and I believe no longer the first line of defense for children at least. The whole thing still burns me.&lt;p&gt;I suspect this sort of information is no longer rare but if anyone is having this experience then a GABA agonist like benzodiazepine may help you, but be extremely careful as they are quickly dependence forming and must be weened. Small dose.</text></item><item><author>stevebmark</author><text>Fluoroquinolone antibiotics like cipro, levaquin, (and generally anything ending in -ofloxacin), can cause permanent nerve damage and one of the presentations is demyelination of the nerves. [1][2][3]&lt;p&gt;Permanent nerve damage (neuropathy, pins and needles, tingling, muscle weakness, spasms, muscle twitches, heart palpitations) is a known side effect. There&amp;#x27;s been no attempt made to study if there&amp;#x27;s any long term delayed brain effects from fluoroquinolones. &amp;quot;Brain fog&amp;quot; is a commonly reported symptom of those who experience fluoroquinolone side effects. I hope there will be more studies on long term brain health from these drugs, as they&amp;#x27;re given out liberally.&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6006604&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6006604&amp;#x2F;&lt;/a&gt;&lt;p&gt;[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7667412&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7667412&amp;#x2F;&lt;/a&gt;&lt;p&gt;[3] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;pubmed.ncbi.nlm.nih.gov&amp;#x2F;10832955&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;pubmed.ncbi.nlm.nih.gov&amp;#x2F;10832955&amp;#x2F;&lt;/a&gt;</text></item></parent_chain><comment><author>adkadskhj</author><text>&amp;gt; On the one hand, I want to chalk this up to them being like everyone else: 90% of them are just shit at their jobs. On the other hand, I have it on good authority from nearly every nurse I&amp;#x27;ve ever met that doctors are indeed arrogant, dismissive, and often mistaken.&lt;p&gt;I think there&amp;#x27;s an extra layer. Any public facing jobs tend to take a toll on you, too. Some more than others. With doctors patients lie to you constantly, for a variety of reasons. Some drug seeking, some simply not wanting to admit it.&lt;p&gt;Yea, i imagine they&amp;#x27;re like everyone else (shit), but i also imagine it is very easy become &lt;i&gt;very&lt;/i&gt; dismissive in that line of work.&lt;p&gt;It&amp;#x27;s a fine line to know what to filter and what to ignore, i imagine.</text></comment>
<story><title>Loss of myelin is one of the major factors of age-related brain deterioration</title><url>https://www.port.ac.uk/news-events-and-blogs/news/brains-wiring-insulation-is-one-of-the-major-factors-of-age-related-brain-deterioration</url></story><parent_chain><item><author>AnIdiotOnTheNet</author><text>&amp;gt; The doctors were completely dismissive of and uninterested in the symptoms -- it really shook my faith in medical practice.&lt;p&gt;I had a similar experience as a child, where a textbook case of a reasonably common disease went undiagnosed for 2 years by doctors before a toll booth worker at an airport diagnosed me. She recognized the symptoms because her dog had it. Sure enough, after my mother brow-beat a doctor into running the absurdly simple blood test she was proven right.&lt;p&gt;On the one hand, I want to chalk this up to them being like everyone else: 90% of them are just shit at their jobs. On the other hand, I have it on good authority from nearly every nurse I&amp;#x27;ve ever met that doctors are indeed arrogant, dismissive, and often mistaken.</text></item><item><author>ctrlp</author><text>I can attest. This happened to my wife 15+ years ago. The reaction began after two doses of Levaquin and was 3 months of non-stop living hell. Seriously painful neuropathy, burning all over her body. Profuse sweating all night. Brutal nightmares. Brain fog. Crippling pain in her appendages, melting walls. Extremely distressing.&lt;p&gt;The doctors were completely dismissive of and uninterested in the symptoms -- it really shook my faith in medical practice. We were on an oddessey to determine what was wrong and could be done to help. It took her 6 months to resume walking more than a short distance. She still has foot and hand problems from permanent neuropathy that affect her daily.&lt;p&gt;A few years after, Levaquin was black-labelled, and I believe no longer the first line of defense for children at least. The whole thing still burns me.&lt;p&gt;I suspect this sort of information is no longer rare but if anyone is having this experience then a GABA agonist like benzodiazepine may help you, but be extremely careful as they are quickly dependence forming and must be weened. Small dose.</text></item><item><author>stevebmark</author><text>Fluoroquinolone antibiotics like cipro, levaquin, (and generally anything ending in -ofloxacin), can cause permanent nerve damage and one of the presentations is demyelination of the nerves. [1][2][3]&lt;p&gt;Permanent nerve damage (neuropathy, pins and needles, tingling, muscle weakness, spasms, muscle twitches, heart palpitations) is a known side effect. There&amp;#x27;s been no attempt made to study if there&amp;#x27;s any long term delayed brain effects from fluoroquinolones. &amp;quot;Brain fog&amp;quot; is a commonly reported symptom of those who experience fluoroquinolone side effects. I hope there will be more studies on long term brain health from these drugs, as they&amp;#x27;re given out liberally.&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6006604&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6006604&amp;#x2F;&lt;/a&gt;&lt;p&gt;[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7667412&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7667412&amp;#x2F;&lt;/a&gt;&lt;p&gt;[3] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;pubmed.ncbi.nlm.nih.gov&amp;#x2F;10832955&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;pubmed.ncbi.nlm.nih.gov&amp;#x2F;10832955&amp;#x2F;&lt;/a&gt;</text></item></parent_chain><comment><author>rectang</author><text>Doctors operate in an environment of extreme uncertainty, because human biology is so complex and so poorly understood.&lt;p&gt;At the same time, doctors are rewarded for acting as though they are certain.&lt;p&gt;Not unlike internet commenters rewarded with karma for condemning doctors across the board with certainty.&lt;p&gt;Humans crave certainty in an uncertain world.</text></comment>