<story><title>A Mechanism for Long Covid</title><url>https://mastodon.nl/@vickyvdtogt/110196805189572082</url></story><parent_chain><item><author>thenerdhead</author><text>&amp;gt; The cause of PASC is currently debated but likely involves several different components, including: viral dissemination and persistence, immune activation and dysregulation (e.g. clotting, autoantibodies and reactivation of pre-existing latent viruses), cell death and tissue damage, and long-lasting cellular changes (e.g. epigenetic changes, senescence, fibroproliferation, metabolism alterations) (3). However, at present we lack an integrative understanding of how these disease components interact to cause the variable symptomology of PASC. Based on studies on acute COVID-19, PASC and the related myalgic encephalomyelitis (ME; chronic fatigue syndrome), we hypothesize that an inflammatory acid-base disruption underpins PASC and that viral proteins, both acutely and persistently-expressed, cause disease symptomology through disseminated tissue damage and inflammatory acid-base disruptions.&lt;p&gt;Seems like an explanation for the body compensating for hypoxic-environments by changing its acid-base. But what is fundamentally causing these environments?&lt;p&gt;Focusing on sleep, diet&amp;#x2F;hydration, and exercise are your three major ways to combat long covid. The latter (exercise) is heavily controversial in the long covid &amp;#x2F; ME&amp;#x2F;CFS communities, but would help moderate your acid-base over the long term if you can push through the pain&amp;#x2F;fatigue&amp;#x2F;etc.&lt;p&gt;The author suggests a few things helped them. Deep breathing, diet changes surrounding acidic foods, and stretching.&lt;p&gt;My personal experience with two bouts of long covid (14 months and 7 months) has me still believing that microclots and nitric oxide deficiency being the key factors in my recovery. I&amp;#x27;ve recovered twice now and back to pre-covid ability. It took me two years of constant exercise to build back to where I was. A modern Sisyphean task at that.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC9212559&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC9212559&amp;#x2F;&lt;/a&gt;</text></item></parent_chain><comment><author>adinb</author><text>&amp;gt; but would help moderate your acid-base over the long term if you can push through the pain&amp;#x2F;fatigue&amp;#x2F;etc.&lt;p&gt;Pushing through is part of the problem. The crash that comes from pushing is the real problem --all kinds of blood markers go amuck after exertion (especially anything aerobic &amp;gt;10m, like a cardio pulmonary exercise test) and stay amuck for about a week. And the more you try to do during the crash the longer or worse the crash becomes. Pushing regardless of crash status, like in graded exercise therapy, has actually caused ME&amp;#x2F;CFS&amp;#x2F;Long Covid baseline symptoms to become worse semi-permanently.</text></comment>
<story><title>A Mechanism for Long Covid</title><url>https://mastodon.nl/@vickyvdtogt/110196805189572082</url></story><parent_chain><item><author>thenerdhead</author><text>&amp;gt; The cause of PASC is currently debated but likely involves several different components, including: viral dissemination and persistence, immune activation and dysregulation (e.g. clotting, autoantibodies and reactivation of pre-existing latent viruses), cell death and tissue damage, and long-lasting cellular changes (e.g. epigenetic changes, senescence, fibroproliferation, metabolism alterations) (3). However, at present we lack an integrative understanding of how these disease components interact to cause the variable symptomology of PASC. Based on studies on acute COVID-19, PASC and the related myalgic encephalomyelitis (ME; chronic fatigue syndrome), we hypothesize that an inflammatory acid-base disruption underpins PASC and that viral proteins, both acutely and persistently-expressed, cause disease symptomology through disseminated tissue damage and inflammatory acid-base disruptions.&lt;p&gt;Seems like an explanation for the body compensating for hypoxic-environments by changing its acid-base. But what is fundamentally causing these environments?&lt;p&gt;Focusing on sleep, diet&amp;#x2F;hydration, and exercise are your three major ways to combat long covid. The latter (exercise) is heavily controversial in the long covid &amp;#x2F; ME&amp;#x2F;CFS communities, but would help moderate your acid-base over the long term if you can push through the pain&amp;#x2F;fatigue&amp;#x2F;etc.&lt;p&gt;The author suggests a few things helped them. Deep breathing, diet changes surrounding acidic foods, and stretching.&lt;p&gt;My personal experience with two bouts of long covid (14 months and 7 months) has me still believing that microclots and nitric oxide deficiency being the key factors in my recovery. I&amp;#x27;ve recovered twice now and back to pre-covid ability. It took me two years of constant exercise to build back to where I was. A modern Sisyphean task at that.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC9212559&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC9212559&amp;#x2F;&lt;/a&gt;</text></item></parent_chain><comment><author>mancerayder</author><text>&amp;gt;  nitric oxide deficiency&lt;p&gt;Wasn&amp;#x27;t there something around Cialis &amp;#x2F; Viagra being explored for covid recovery?  Since those drugs act on that, maybe there&amp;#x27;s a potential connection?</text></comment>