<story><title>Disappearing Polymorphs</title><url>https://en.wikipedia.org/wiki/Disappearing_polymorphs</url></story><parent_chain></parent_chain><comment><author>colanderman</author><text>&amp;gt; Form II was of sufficiently lower energy that it became impossible to produce Form I in any laboratory where Form II was introduced, even indirectly. Scientists who had been exposed to Form II in the past seemingly contaminated entire manufacturing plants by their presence, probably because they carried over microscopic seed crystals of the new polymorph.&lt;p&gt;If someone told me this entire article was fabricated I would believe them.  I would never have thought that such trace amounts of… everything one has ever shared a room with, essentially follow them everywhere dispersing as they go.  Chemistry is wild.</text></comment>
<story><title>Disappearing Polymorphs</title><url>https://en.wikipedia.org/wiki/Disappearing_polymorphs</url></story><parent_chain></parent_chain><comment><author>cvoss</author><text>&amp;gt; a phenomenon in which a seemingly stable crystal structure is suddenly unable to be produced&lt;p&gt;The whole intro to this article really undersold to me how significant a phenomenon this is describing. My jaw dropped when I got into the Case Studies section. Apparently there are certain drugs which are nigh impossible to make today because a more stable (but medically ineffective (or still patented)) version of the crystal was once created and now contaminates the atmosphere in microscopic quantities.</text></comment>