<story><title>Deep sleep may be the best defense against Alzheimer’s</title><url>https://www.wsj.com/articles/deep-sleep-may-be-the-best-defense-against-alzheimers-memory-amlyoid-1524dbd7</url></story><parent_chain><item><author>aantix</author><text>I&amp;#x27;ve posted this before, but it&amp;#x27;s worth repeating.&lt;p&gt;I recently discovered that I’m a slow metabolizer of caffeine. Via my raw 23andme data.
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;you.23andme.com&amp;#x2F;tools&amp;#x2F;data&amp;#x2F;?query=rs762551&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;you.23andme.com&amp;#x2F;tools&amp;#x2F;data&amp;#x2F;?query=rs762551&lt;/a&gt;&lt;p&gt;C&amp;#x2F;C genotype.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.geneticlifehacks.com&amp;#x2F;liver-detox-genes-cyp1a2&amp;#x2F;#C&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.geneticlifehacks.com&amp;#x2F;liver-detox-genes-cyp1a2&amp;#x2F;#C&lt;/a&gt;...&lt;p&gt;Instead of coffee being a net positive, it actually takes caffeine 4X the time to process through my body. It also increases my cardiac event risk (most normal metabolizers it does not).&lt;p&gt;I can drink a cup of coffee at 8am and it still impacts my sleep the following night. My blood pressure remains really elevated (20+ points for systolic) the entire day.&lt;p&gt;All these decades I’ve been ingesting coffee thinking it’s a “net positive” - not for my genotype.&lt;p&gt;When the reality is I sleep like shit, my blood pressure is through the roof, I feel awful for a day or two of drinking a single cup, and it all makes sense now.&lt;p&gt;Even with just 30mg ingested this morning at 8am, I still feel very wide awake at 9pm.&lt;p&gt;When I totally detox from caffeine, go through the headaches, I ultimately feel calmer, and I get the best, deepest sleep.</text></item></parent_chain><comment><author>thrtythreeforty</author><text>Is there a way I can get this kind of analysis done and retain control of all the data that gets created? I have been interested in learning details about my genotype for a while, but not at the expense of having 23andMe keep a copy for whatever purpose they desire now or in the future.</text></comment>
<story><title>Deep sleep may be the best defense against Alzheimer’s</title><url>https://www.wsj.com/articles/deep-sleep-may-be-the-best-defense-against-alzheimers-memory-amlyoid-1524dbd7</url></story><parent_chain><item><author>aantix</author><text>I&amp;#x27;ve posted this before, but it&amp;#x27;s worth repeating.&lt;p&gt;I recently discovered that I’m a slow metabolizer of caffeine. Via my raw 23andme data.
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;you.23andme.com&amp;#x2F;tools&amp;#x2F;data&amp;#x2F;?query=rs762551&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;you.23andme.com&amp;#x2F;tools&amp;#x2F;data&amp;#x2F;?query=rs762551&lt;/a&gt;&lt;p&gt;C&amp;#x2F;C genotype.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.geneticlifehacks.com&amp;#x2F;liver-detox-genes-cyp1a2&amp;#x2F;#C&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.geneticlifehacks.com&amp;#x2F;liver-detox-genes-cyp1a2&amp;#x2F;#C&lt;/a&gt;...&lt;p&gt;Instead of coffee being a net positive, it actually takes caffeine 4X the time to process through my body. It also increases my cardiac event risk (most normal metabolizers it does not).&lt;p&gt;I can drink a cup of coffee at 8am and it still impacts my sleep the following night. My blood pressure remains really elevated (20+ points for systolic) the entire day.&lt;p&gt;All these decades I’ve been ingesting coffee thinking it’s a “net positive” - not for my genotype.&lt;p&gt;When the reality is I sleep like shit, my blood pressure is through the roof, I feel awful for a day or two of drinking a single cup, and it all makes sense now.&lt;p&gt;Even with just 30mg ingested this morning at 8am, I still feel very wide awake at 9pm.&lt;p&gt;When I totally detox from caffeine, go through the headaches, I ultimately feel calmer, and I get the best, deepest sleep.</text></item></parent_chain><comment><author>someotherperson</author><text>Totally anecdotal, but have you tried coupling it with L-Theanine?&lt;p&gt;I&amp;#x27;ve become extremely caffeine sensitive over the last few years -- anything more than about 80mg has me off the walls for the entire day. But ensuring I get L-Theanine along with it essentially blunts the response quite significantly and allows me to function normally.</text></comment>