<story><title>Mice live longer when inflammation-boosting protein is blocked</title><url>https://www.nature.com/articles/d41586-024-02298-5</url></story><parent_chain><item><author>olalonde</author><text>Excerpt from a book I just read, The Renaissance Diet 2.0:&lt;p&gt;&amp;gt; What about all those cancer studies [about artificial sweeteners] in rats? The first study that initiated this scare was done in the 1970s, and saccharin at high doses was found to cause bladder cancer in rats. Pretty scary, except that in the early 2000s, it was shown that this reaction to saccharin was unique to rats and mechanistically impossible in humans. To illustrate the point, it has also been shown that vitamin C increases tumor growth in rats and mice, but does not seem to have tumor growth effects in humans.&lt;p&gt;Just sharing as a reminder that studies on animals do not necessarily translate to humans.</text></item></parent_chain><comment><author>hombre_fatal</author><text>The translation rate is surprisingly bad.&lt;p&gt;&amp;gt; Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plosbiology&amp;#x2F;article?id=10.1371&amp;#x2F;journal.pbio.3002667&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plosbiology&amp;#x2F;article?id=10.1371&amp;#x2F;jou...&lt;/a&gt;</text></comment>
<story><title>Mice live longer when inflammation-boosting protein is blocked</title><url>https://www.nature.com/articles/d41586-024-02298-5</url></story><parent_chain><item><author>olalonde</author><text>Excerpt from a book I just read, The Renaissance Diet 2.0:&lt;p&gt;&amp;gt; What about all those cancer studies [about artificial sweeteners] in rats? The first study that initiated this scare was done in the 1970s, and saccharin at high doses was found to cause bladder cancer in rats. Pretty scary, except that in the early 2000s, it was shown that this reaction to saccharin was unique to rats and mechanistically impossible in humans. To illustrate the point, it has also been shown that vitamin C increases tumor growth in rats and mice, but does not seem to have tumor growth effects in humans.&lt;p&gt;Just sharing as a reminder that studies on animals do not necessarily translate to humans.</text></item></parent_chain><comment><author>Terr_</author><text>&amp;gt;  To illustrate the point, it has also been shown that vitamin C increases tumor growth in rats and mice, but does not seem to have tumor growth effects in humans.&lt;p&gt;Worth noting that regular (non-GMO) mice can synthesize their own vitamin-C without needing it &amp;quot;pre-made&amp;quot; in their diet, unlike [clarification-edit: some but not all] primates (i.e. humans) and sporadic clusters of animals.&lt;p&gt;In other words, there are already some pretty important differences between how the two species process normal amounts of that nutrient.</text></comment>