<story><title>Pre-exposure to mRNA-LNP inhibits adaptive immune responses in mice</title><url>https://pubmed.ncbi.nlm.nih.gov/36054264/</url></story><parent_chain><item><author>mabbo</author><text>&amp;gt;  On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased.&lt;p&gt;It sounds to me as though the tradeoff being made here is: a slightly decreased immune response generally, but a better immune response to the thing you&amp;#x27;ve been immunized against. That seems to be a reasonable tradeoff if there&amp;#x27;s something really bad going around.&lt;p&gt;But as they say in the paper summary: more research is needed.&lt;p&gt;Also: this is purely in mice. They have zero data on whether this is true for humans.</text></item></parent_chain><comment><author>lazyier</author><text>I donno.  Seems like white blood cells are kinda important.&lt;p&gt;We have a huge number of interactions with bacteria and viruses and all sorts of microorganisms. Hundreds? Thousands times a day?  Scratches in the kitchen while preparing food, for example, floods our body with stuff that white blood cells are required to deal with.&lt;p&gt;Giving up some of the ability to deal with those for a small reduction in the symptoms associated with a specific disease doesn&amp;#x27;t seem like a useful trade off.</text></comment>
<story><title>Pre-exposure to mRNA-LNP inhibits adaptive immune responses in mice</title><url>https://pubmed.ncbi.nlm.nih.gov/36054264/</url></story><parent_chain><item><author>mabbo</author><text>&amp;gt;  On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased.&lt;p&gt;It sounds to me as though the tradeoff being made here is: a slightly decreased immune response generally, but a better immune response to the thing you&amp;#x27;ve been immunized against. That seems to be a reasonable tradeoff if there&amp;#x27;s something really bad going around.&lt;p&gt;But as they say in the paper summary: more research is needed.&lt;p&gt;Also: this is purely in mice. They have zero data on whether this is true for humans.</text></item></parent_chain><comment><author>usrusr</author><text>Had those mice been immunized against influenza? That&amp;#x27;s not what I read, but I might have miss it. What I read is that they used the vector without any payload, and it turned out that influenza is an example of something nominally  unrelated where resistance was slightly increased while candida albicans (no idea what that is, not a native speaker) are an example for slightly lessened resistance.&lt;p&gt;Lines up well with my mental model of how the immune system deals with the unknown: a million monkeys not on typewriters but on text editors with copy&amp;#x2F;paste. Who fire new code, aimlessly mashed up from their library of previous experience, at a test fixture. Any change to unrelated previous experience can increase or decrease their chance of finding something that sticks.</text></comment>