<story><title>mRNA Cancer Vaccine Reprograms Immune System to Tackle Glioblastoma in 48 Hours</title><url>https://www.insideprecisionmedicine.com/topics/oncology/mrna-cancer-vaccine-reprograms-immune-system-to-tackle-glioblastoma/</url></story><parent_chain></parent_chain><comment><author>femto</author><text>Richard Scolyer, first patient for a Glioblastoma vaccine, is 10 months in and counting.  (I&amp;#x27;m not sure if it&amp;#x27;s mRNA based.)  The treatment was vaccine, followed by surgery to remove the tumour, followed by more vaccine to prevent recurrence.  The vaccine course is up to 8 out of 10 planned doses.  So far it hasn&amp;#x27;t come back.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.facebook.com&amp;#x2F;ProfRScolyer&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.facebook.com&amp;#x2F;ProfRScolyer&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;en.wikipedia.org&amp;#x2F;wiki&amp;#x2F;Richard_Scolyer#Cancer_diagnosis_and_treatment&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;en.wikipedia.org&amp;#x2F;wiki&amp;#x2F;Richard_Scolyer#Cancer_diagnos...&lt;/a&gt;</text></comment>
<story><title>mRNA Cancer Vaccine Reprograms Immune System to Tackle Glioblastoma in 48 Hours</title><url>https://www.insideprecisionmedicine.com/topics/oncology/mrna-cancer-vaccine-reprograms-immune-system-to-tackle-glioblastoma/</url></story><parent_chain></parent_chain><comment><author>adamredwoods</author><text>Sounds effective, I&amp;#x27;ve always had a hunch the real path to controlling cancer is not a singular approach. Cancer mutates too much.&lt;p&gt;&amp;gt;&amp;gt; “Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions, like a bag full of onions,” said Elias Sayour, MD, PhD, a UF Health pediatric oncologist who pioneered the new vaccine. “And the reason we’ve done that in the context of cancer is these clusters alert the immune system in a much more profound way than single particles would.” Results from the canine trial showed how the vaccine reprogrammed the tumor microenvironment (TME) within days, allowing the activated immune system cells to fight the tumor.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.cell.com&amp;#x2F;cell&amp;#x2F;abstract&amp;#x2F;S0092-8674(24)00398-2&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.cell.com&amp;#x2F;cell&amp;#x2F;abstract&amp;#x2F;S0092-8674(24)00398-2&lt;/a&gt;</text></comment>