<story><title>Direct evidence for T-cell immunity as a factor behind Covid-19 heterogeneity</title><url>https://science.sciencemag.org/content/early/2020/08/04/science.abd3871</url></story><parent_chain></parent_chain><comment><author>trenchgun</author><text>Misleading headline. From the article:&lt;p&gt;&amp;gt; Based on these data, it is plausible to hypothesize that pre-existing cross-reactive HCoV CD4+ T cell memory in some donors could be a contributing factor to variations in COVID-19 patient disease outcomes, but this is at present highly speculative&lt;p&gt;Also I recommend to read this:
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.theatlantic.com&amp;#x2F;health&amp;#x2F;archive&amp;#x2F;2020&amp;#x2F;08&amp;#x2F;covid-19-immunity-is-the-pandemics-central-mystery&amp;#x2F;614956&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.theatlantic.com&amp;#x2F;health&amp;#x2F;archive&amp;#x2F;2020&amp;#x2F;08&amp;#x2F;covid-19-...&lt;/a&gt;</text></comment>
<story><title>Direct evidence for T-cell immunity as a factor behind Covid-19 heterogeneity</title><url>https://science.sciencemag.org/content/early/2020/08/04/science.abd3871</url></story><parent_chain></parent_chain><comment><author>nostromo</author><text>&amp;gt; We demonstrate a range of pre-existing memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63, or HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in COVID-19 disease.&lt;p&gt;Could we just start deliberately spreading these weaker cold viruses then?</text></comment>