<story><title>A chemical so hot it destroys nerve endings – in a good way</title><url>https://www.wired.com/story/resiniferatoxin/</url></story><parent_chain></parent_chain><comment><author>mabbo</author><text>Naturally I wanted to know if anyone had tried cooking with or eating this super spicy compound. I found this [0]:&lt;p&gt;&amp;gt; “With a friend, we put one drop of a very dilute solution”—he pointed to the tip of his tongue—“and then immediately rinsed it off. At the point where we put it, I couldn’t feel anything for a week.”&lt;p&gt;To anyone with the same bad idea as me, the answer is no, we don&amp;#x27;t want to eat these.&lt;p&gt;[0] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.cooksillustrated.com&amp;#x2F;science&amp;#x2F;783-articles&amp;#x2F;feature&amp;#x2F;hurts-so-good&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.cooksillustrated.com&amp;#x2F;science&amp;#x2F;783-articles&amp;#x2F;featur...&lt;/a&gt;</text></comment>
<story><title>A chemical so hot it destroys nerve endings – in a good way</title><url>https://www.wired.com/story/resiniferatoxin/</url></story><parent_chain></parent_chain><comment><author>mirimir</author><text>This sounds wonderful for chronic pain. Reportedly, only pain neurons are affected. And for joints and other relatively isolated sites, effects can be targeted. So yes, your knee doesn&amp;#x27;t hurt, and you could injure it worse without the pain feedback. But you&amp;#x27;d have ~normal pain sensation elsewhere.&lt;p&gt;We already use capsaicin patches. So hey.</text></comment>