Introduction {#sec0005}
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American trypanosomiasis, a chronic systemic parasitosis also known as Chagas' disease (CD), is caused by the protozoan kinetoplastid parasite *Trypanosoma cruzi*. CD has afflicted humanity since its earliest presence in the New World and is still the largest parasitic disease burden of the American continent. The disease is technically a zoonosis, as the natural reservoirs of the *T. cruzi* are a large variety of marsupial and placental mammals autochthonous to the American continent, the parasite being naturally transmitted among them by Reduviid (Triatominae) hematophagous insects. Human disease results from the invasion of natural ecotopes, as well as from the establishment of the vectors in human dwellings, due to the poor socioeconomic conditions of most rural human populations from Mexico to Argentina, where the disease is endemic. Vector-bornecongenital transmission of *T. cruzi* from infected mothers to infants [@bib0035]. The first documented case of congenital transmission in the United States was recorded in 2012 [@bib0040]. The patient was born by cesarean section at 29 weeks of gestational age due to fetal hydrops from an asymptomatic mother with history of Chagas disease diagnosed in Bolivia (country of origin), but never treated for the infection [@bib0040].

We report two adult male siblings with presumptive congenital transmission of *T. cruzi*, born in the United States to a Bolivian seropositive mother, who had a strong epidemiological exposure to triatomine insects 28 years prior to her migration to the United States.

Case reports {#sec0010}
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Case 1: A 24-year-old Hispanic male was referred by the Florida Health Department for evaluation after a voluntary blood donation