Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation.
Saquinavir mesylate (SM) is a protease inhibitor with activity against human immunodeficiency virus type 1 (HIV-1) and is available in tablet form, which has three major problems. First, the drug undergoes extensive first pass metabolism. Second, the drug has a poor aqueous solubility. And third, it has low GIT permeability and absorption. These constrains lead to decrease oral bioavailability (4% only) and administration of large doses which increase the incidence of occurrence of the side effects. The aim of this research was to utilize nanotechnology to formulate (SM) into a nasal in situ nanosized microemulsion gel (NEG) to provide a solution for the previously mentioned problems. The solubility of (SM) in various oils,When New York Fashion Week comes to town in the first week of September, a cadre of young designers will host exclusive catwalk shows all over Manhattan, generating a buzz for nascent brands as well as their seasonal offerings of exquisite studio creations.

Yet for many, the whole game has also changed. Today few fledgling visionaries are ever judged purely on artistic ingenuity. To secure a coveted spot at this year’s show calendar – and thereby catch the eye of those at the top – twenty-something talents need to show not just a brilliance for producing creative collections but also a commercially sharpened brain for the business that will foster their survival in this tough climate for the industry.

In less than three years, up-and-coming talent Wes Gordon, a 27-year