Experimental central hypertension produced by chemical degeneration of the locus coeruleus in the rat.
The role of noradrenergic neurons originating from the locus coeruleus (LC) in blood pressure regulation was studied by stereotaxic administration of 6-hydroxydopamine (6-OHDA) into the LC in Wistar-Kyoto rats. The administration of 6-OHDA (12 micrograms/6 microliters) into the bilateral LC resulted in hypertension and tachycardia, which lasted for 12 days and gradually returned to the levels observed before administration. The systolic blood pressure and heart rate were 172 mmHg and 460 beats/min on the mean respectively, one day after administration. The induced hypertension and tachycardia were closely correlated with the depletion of norepinephrine (NE) content in the cortex and the medulla-pons in rats in a hypertensive state. The correlation between the NE content of theits analysis by the end of this year.

The agreement includes a two-phased approach that will help NASA assess potential opportunities for collaboration. During the first phase, Bigelow will leverage its existing relationships with other private companies and its expertise from continuing operations in space to form common objectives between the private sector and NASA. In the second phase, Bigelow will create a series of options for public-private collaboration that lower costs and takes advantage of rapid implementation.