Innovative approaches for designing and analyzing adaptive dose-ranging trials.
Inadequate selection of the dose to bring forward in confirmatory trials has been identified as one of the key drivers of the decreasing success rates observed in drug development programs across the pharmaceutical industry. In recognition of this problem, the Pharmaceutical Research and Manufacturers of America (PhRMA), formed a working group to evaluate and develop alternative approaches to dose finding, including adaptive dose-ranging designs. This paper summarizes the work of the group, including the results and conclusions of a comprehensive simulation study, and puts forward recommendations on how to improve dose ranging in clinical development, including, but not limited to, the use of adaptive dose-ranging methods.and international trade matters in the House of Lords.

A spokesman for Labour leader Jeremy Corbyn said: "It's right that Lord Mendelsohn has stepped down.

"The reports about this appalling event were deeply shocking and there can be no excuse for anyone's attendance."

The President’s Club will not host any further fundraising events following the media storm that erupted over undercover reporting at the charity fundraiser.

The furore also saw one of the organisers, David Meller, step down from his role as a non-executive director for the board of the Department for Education.

The remaining funds raised by the club will be distributed in an efficient manner to children's charities and it will then be closed," the organisation said in a statement on Wednesday afternoon.

Scotland Yard was also today under growing pressure to