[Aflatoxins: current concepts on mechanisms of toxicity and their involvement in the etiology of hepatocellular carcinoma].
Current concepts derived from intensive research over the last decade, on biotransformation, mechanisms of toxicity and evidences for the involvement of aflatoxins in the etiology of human liver cancer are summarily presented. Aflatoxin B1(AFB1), the main metabolite produced by moulds of genus Aspergillus, exerts its effects after conversion to the reactive compound AFB1-epoxide, by the action of cytochrome P450-dependent enzymes. This epoxide can form derivatives with cellular macromolecules, including proteins, RNA and DNA. The reaction with DNA occurs with guanines in the códon 249 of tumor suppressor gene p53. Primary biotransformation of AFB1 also produces hydroxylated and less toxic derivatives, such as aflatoxins Q1 and P1. Differences intra and interspecies in the pathwayswent up and was successfully used by 2500 people, a significant number. Also, and this did deserve a mention earlier today, but the miabsetee.com app/site was VERY successful and helped both many Democrats and Republicans register to vote. Lon and his leadership team deserve lots of kudos for that piece of brilliance.That clarification was important to include.

Tomorrow Democrats from across the state will convene in downtown Detroit for their semi-annual convention. The spring convention will hold no surprises tomorrow.…

Today is December 15, 2014 and that, in itself might mean many things to you. However, for political observers, pundits, analyzers, etc., today marks the final days of the Michigan Legislative agenda for 2014 and will also usher in, in a few very short weeks, a new House and Senate.