CJD-caused mortality data. Statistical reports from the Eye Bank Association of America (EBAA) were used to collect data relevant to cornea donation in the United States.

Search parameters were set to include:

Creutzfeldt-Jakob Disease, Cornea CJD, CJD Risk Factors, CJD Transmission, CJD Case Reports, CJD Mortality, Corneal Donation, Prion Proteins, Cornea Anatomy and Physiology, History of Corneal Transplantation in the United States, Iatrogenic Transmission of CJD, Iatrogenic transmission of CJD through Corneal Transplantation, Ocular Tropism of Viruses, Detection of Prion Diseases, Iatrogenic Transmission of CJD through Dura Mater, Iatrogenic Transmission of CJD through Growth Hormone, Iatrogenic Transmission of Disease through Corneal Transplantation, Case reports of Iatrogenic Transmission of CJD through Corneal Transplantation in the United States, Corneal Donor Statistics in the United States, Latency Period of CJD, Detection of Creutzfeldt-Jakobthe CDC for 2018 were then applied to the estimated prevalence of CJD in each age category to determine the number of deceased individuals with latent CJD. The number of CJD-affected corneas generated is thus twice the number of deceased individuals with latent CJD. The chance that any cornea enters the relatively small pool of corneas intended for transplant is defined as the ratio of EBAA-reported corneas in the transplant pool in a given year to the total number of corneas generated by all-cause mortality in the same year. This ratio for each age category was then applied to the overall number of CJD-affected corneas generated in 2018 to determine the number of CJD-affected corneas that entered the transplant-intended pool. This analysis was performed for each age group