Management impact: effects on quality of life and prognosis in MEN1.
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant endocrine tumor syndrome, caused by inactivating mutations of the MEN1 tumor suppressor gene at 11q13 locus, which predisposes to develop tumors in target neuroendocrine tissues. As the positional cloning and identification of the causative gene in 1997, genetic diagnosis, by the sequencing-based research of gene mutations, has become an important tool in the early and differential diagnosis of the disease. Application of the genetic test, in MEN1 index cases and in first-degree relatives of mutated patients, has been constantly increasing during the last two decades, also thanks to the establishment of multidisciplinary referral centers and specific genetic counseling, and thanks to the wide availability of high throughput instrumentsHouse Speaker Nancy Pelosi accused President Trump of racism again on Saturday, after he described Rep. Elijah Cummings' congressional district as "the worst run and most dangerous anywhere in the United States."

The big picture: This is the second time this month that Trump has publicly attacked a black member of Congress. He told Rep. Ayanna Pressley and 3 other congresswomen of color to "go back" to their countries earlier this month, which his rally-going supporters echoed in chants last week.

What he's saying: Cummings responded to the president's criticism of Baltimore on Saturday by asking him to reconsider endorsing a bill to let the government negotiate for lower prescription drug prices.

Go deeper: Trump unleashes attack on Baltimore while criticizing Elijah Cummings