history of problem pregnancies. There was a great deal of activity in this area from the mid-1940s to the mid-1950s, much of it coming out of Boston. Information was exchanged among the obstetricians, based both on personal experience with the drug and numerous articles in medical journals.
In 1947, in order to benefit from all this interest and activity, many drug companies filed additional NDAs requesting authorization to market DES in larger dosages to treat pregnancy problems.
Both the enthusiasm and the activity waned in the late 1950s. In 1971 a statistical correlation was discovered between clear cell adenocarcinoma and DES. As recently as 1970, however, it was still prescribed, although rarely for pregnant women. It was in that year that a report was published which documented observation of theEthereum, which is the second largest cryptocurrency in terms of the market cap now has more unique and active addresses than industry leader Bitcoin.

Ethereum has successfully doubled its number of unique and active addresses since December last year, taking the total number to 35 million unique addresses and 100,000 new registrations every day. Bitcoin meanwhile has 24 million unique addresses according to data last checked March 2018, as its blockchain explorer no longer provides this data.

Despite this development, the growth has actually slowed down for Ethereum which previously welcome more than 300,000 new addresses on several days back in January. The bear market which has been in play since the start of the year is seen as the major reason for the reduction in the number of new