epigenetic changes.

Diet:The Dutch Hunger Winter occurred 1944-1945 when food supply in the German-occupied Netherlands was blocked off during World War II. Food became scarce and all rations were meticulously recorded. Babies born during this period were unusually small and prone to develop coronary heart disease. Six decades later, scientists used archived data to reach out to survivors who were developing in the womb during the famine. Same-sex siblings born before or after the famine served as controls. Through blood sample analysis, scientists discovered that offspring developing in the womb during the famine had differences in methylation of certain genes compared to their siblings. Interestingly, these differences were associated with a higher body mass index (BMI). Additionally, another study on famine survivors found increased risks of obesity, type 2The present invention relates to a solid stick external analgesic composition. More particularly, this invention relates to physically and chemically stable solid stick compositions for the topical administration of salicylate esters.
Externally applied analgesic compositions are useful in providing relief from minor pain and discomfort in muscles and joints. Such external analgesics may exhibit topical analgesic, topical anesthetic, topical antipruritic, or counterirritant effects. See P. Skierkowski and N. C. Lublanezki, "External Analgesic Products," in Handbook of Nonprescription Drugs, 7th ed.; American Pharmaceutical Association and the National Professional Society of Pharmacists: Washington, D.C., 1982; pp. 513-523. Because counterirritants abate the perception of pain and induce a mild inflammatory reaction, thereby producing a feeling of warmth, counterirritant drugs are commonly used external analgesics. Since methyl salicylate, also known as oil of