and repriced a number of early retirement benefit enhancement options with an outside actuarial consultant and prepared to make a presentation to the Board of Directors of Honda.
The Board was presented with three early retirement options by Enoki and Kessler on September 24, 1999, and on that date the Board voted to amend the Plan by adopting one of the early retirement enhancement options presented. The enhancement only applied to people retiring after January 1, 2000.
DiAmore flew to Connecticut for his last day of work, October 11. On that date, he was advised of the early retirement enhancement. Prior to this date, DiAmore had set for himself a final cut-off date of October 7 in order to see if Honda was *85 going to offer enhancement benefits. Neitheror within accessory cells.

Toll-like receptors 
The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in part, due to the presence of immune receptors called Toll-Like Receptors (TLRs) that are expressed on the membranes of leukocytes including dendritic cells, macrophages, natural killer cells, cells of the adaptive immunity (T and B lymphocytes) and non-immune cells (epithelial and endothelial cells, and fibroblasts).

The binding of ligands – either in the form of adjuvant used in vaccinations or in the form of invasive moieties during times of natural infection – TLR marks the key molecular events that ultimately lead to innate immune responses and the development of antigen-specific acquired immunity.

As of 2016, several TLR ligands were in clinical development or being tested in animal models