Prostate cancer is the most prevalent cancer among American men and is classified as the second leading cause of their cancer mortality. In the United States, there will be 220,900 new cancer cases in 2003 making prostate cancer one of the cancers with the fastest rising incidence in this country as well as in Western Europe. While certain dietary, genetic, lifestyle and environmental factors are implicated in prostate cancer risk, the molecular mechanisms underlying the etiology of the disease are largely unknown. Mutagenic oxidative DNA base damage increases with age in prostatic tissue. Many factors may influence this increase including: increased production of reactive oxygen species, increased susceptibility to oxidative stress, alterations in detoxifying enzyme levels or defects in DNA repair. Several research groups have begun to identifyending a defendant's right to change a not guilty plea once a trial has begun, in a move designed to encourage earlier guilty pleas thus saving the cost of trials.

How is that going to work then? Jimmy "The Blagger" Murphy is on trial for a robbery, not for the first time in his life. He goes Not Guilty, as he always does, relying on his latter-day Rumpole's skills with a jury, and hoping that one or two key witnesses will develop amnesia on key bits of evidence, with or without 'encouragement' from his mates. The Crown opens its case. To Jimmy's chagrin, all of the witnesses appear to have turned up, and the forensics don't look too good either. Down in the cells, he has a chat with