Introduction: twenty five years of the Gibbs Conference on Biothermodynamics.
In 2011, the Gibbs Conference on Biothermodynamics will celebrate its 25th anniversary. Since the inaugural meeting in 1987, it has brought together laboratories that lived, breathed and argued about the molecular logic of macromolecular machines. The participants have a deep commitment to understanding the nature of physico-chemical forces that govern regulation of biological systems, and share a passion for applying linkage theory. The collective goal is to understand how ligand binding, subunit assembly and conformational change drive what we observe as physiological processes such as regulated transport, enzyme cascades, gene regulation, membrane permeability, viral infection, intracellular trafficking and folding of macromolecules. In this special issue, articles by former organizers of the Gibbs Conference showcase the current breadth and depthKingdom of Israel had already been scattered into Asia and the Island of Japan before Moab and Ammon arrived approx 702B.C. Here is Wikipedia backing up what the Bible is already saying.Moab Decline and fallFrom Wikipedia"Sometime during the Persian period Moab disappears from the extant historical record. Its territory was subsequently overrun by waves of tribes -FROM NORTHERN ARABIA- including the Kedarites and (later) the Nabataeans. In Nehemiah 4:1 the Arabs are mentioned instead of the Moabites as the allies of the Ammonites. Their region, however, continued to be known by its biblical name for some time. For example, when the Crusaders occupied the area, the castle they built to defend the eastern part of the Kingdom of Jerusalem was called Krak des Moabites."Amos 9:9(Kjv)9 For, lo, I