as well as signs of their credibility and the way they are used. In particular, he described the significance of very strong substances, and he also mentioned anti-inflammatory drugs. "Materia Medica" is written in Greek language and consists of five parts describing fragrant substances, oils, ointments, trees and their juices, resins and fruits, animals, wax, milk of various animals, grains, vegetables, grass, roots, seeds, wine, mineral and metal materials.

Dioskurides has also used various types of fruits (such as plum-tree resins used against stones) as a medicine. It also used the darnel (Lolium temulentum), Fenugreek (Foenum graecum), mallow, trumpet, water mint, coriander, garlic, red pepper, mustard, anemone, ivy, rosewood (Chelidonium), agaric (Agaricusalbus), Liquiritia, Erythrea centaurium, akantus, ononis, tragacanth, sage (Salvia) and many others. Sea squill (Scallamaritima) was already knownas a "waterborne drug", or diuretic. Dioskurides used stone mills to grind the medicines. During the reign of Goth in Italy (493-553) Dioskurides "Materia Medica" was translated into barbarian Latin.

**Galen** based on the knowledge of ancestors, continued to improve health care in the Roman Empire. Galen used Dioskurides "Materia Medica", which he supplemented and wrote 11 books on "Mixing and Characteristics of Simple Medicines". About 20 years later he wrote the book "Compilation of drugs according to their nature" and "Compilation of medicines by site on the body ". These books later on came through the Vizant to Arabs, and they served them as a basis for their pharmacology. With Galen begins a new chapter not only in the medicine and pharmacy of old Rome, but also in