are spaced apart by interstitial spaces formed in the extension of the surface of the optical guide. These interstitial spaces, meaning not covered with microstructures and fitting between them, are transparent and thus allows obtaining see-through effect. This enables seeing the image transported by the light beam, as well the scenes beyond the optical guide. These interstitial spaces however imply a phenomenon equivalent to a diffraction through a slot, which causes interference on the vision of the surrounding scenes through the optical guide.
It is desirable to overcome these various drawbacks of the prior art.
It is in particular desirable to provide a solution that enables a user of the optical guide to see an image, injected into the guide, so as to be superimposed on the scene taking place"This is the first new biological structure solved with a free-electron laser," said Chapman.

The researchers had investigated tiny crystals of the parasite's enzyme cathepsin B with intense X-rays from the free-electron laser Linac Coherent Light Source (LCLS) at the US National Accelerator Laboratory SLAC in California. "The enzyme had emerged as a promising drug target in earlier trials", said Redecke, one of the first authors of the scientific paper. "The knockdown of this essential enzyme in the parasite did cure the infection in mice."

But the same enzyme is also part of the human - and in fact of all mammalian - biochemistry, and blocking it has severe consequences. With their analysis the scientists could now pinpoint distinctive structural differences between the human and the parasite's form of the