ragged mustache, similar to his normal self. Dr. Mario also wears brown work shoes like his normal self, but he dons a doctor's regular form of attire: white pants, a white collared shirt, a red tie, and a white coat, as well as a stethoscope. Despite this, Dr. Mario's design has undergone several changes throughout his history.

In his first self-titled game, Dr. Mario lacks a tie, his shirt is a darker color, and his hair is distinctly lighter than Mario's. In Dr. Mario 64, Dr. Mario's hair is closer to Mario's in color (though still a lighter shade of brown), while he now wears his signature tie. From Dr. Mario Online Rx onwards, Dr. Mario's skin is fair akin to his normal counterpart's; his design remains the samein all future games.

Within the Super Smash Bros. series, Dr. Mario's appearance also evolves. In Super Smash Bros. Melee, Dr. Mario has auburn hair, a brown headband, and a tanned complexion, reflecting his then-recent appearance in Dr. Mario 64, as well as Mario's appearance in Mario Kart 64. Dr. Mario's hair and clothing have more realistic details, while his pants' color is changed to black altogether. In Super Smash Bros. for Nintendo 3DS / Wii U, Dr. Mario's hair is brown like Mario's, while his overall design is more vibrant and cartoonish; however, he retains his unique gray pants, which are slightly rolled up to his ankles while his head-band is colored gray. In Super Smash Bros. Ultimate, while his headband is recolored again brown. Dr. Mario gains