[Ultrastructural study of the neuronal lipofuscin--an autopsy case of familial Alzheimer's disease].
This work is to study the ultrastructure of the neuronal lipofuscin that occurred in the brain and the spinal cord of an autopsy case of familial Alzheimer's disease and to compare with those in several other diseases. The patient was a 46-year-old male, whose father and elder brother were diagnosed as Alzheimer's disease and died at the age of 42, respectively. He became afflicted with forgetfulness and disorientation at the age of 36. He developed a grand mal seizure at the age of 39 and thereafter, his clinical course was characterized by pyramidal signs, dysarthria and the symptoms of Gerstmann's syndrome, visuo-spatial agnosia, apraxia for dressing and constructive apraxia. He became bedridden at 45 years old andwant us for?"

"Her Christmas vacation starts on December twenty-first, I think. Something like that. Why don't you come out then?"

"She won't still be working, will she, Bernard?"

He smiled at her. "I've been surrounded by stubborn women all my life. She's going to work right up until the Easter holidays, and then take a leave from school after that. Her friend Tracy will substitute for her. They already have it all worked out between them."

"Meshuggeneh. She should be home in bed by then."

He shrugged. "She won't, and the doctor says she can work right till the end... so will you come?"

There was a twinkle in her eyes as she smiled at him. "What do you think? You think I'm not going to come and visit my only son, in