An autopsy study of a familial oculopharyngeal muscular dystrophy (OPMD) with distal spread and neurogenic involvement.
An 81-year-old man from a family with a history of oculopharyngeal muscular dystrophy (OPMD) involving 6 members over 4 generations is described. The patient first noted drooping of his eyelids at the age of 65. Dysphagia and dysarthria occurred soon thereafter. At age 78, impairment of gait developed and progressive wasting occurred in the limbs with an initial distal distribution. Electromyography of several limb muscles displayed a mixed myopathic and neurogenic pattern with giant potentials. Examination at autopsy revealed slight loss of neurons in the anterior horns of the spinal cord, with scanty ghost cells, neuronophagia, and central chromatolysis. By light microscopy the limb muscles showed moderate small-group atrophy with severe myopathy andartists like Lisa Frank—who was the reigning queen of stickers, markers and Trapper Keepers in the ’90s—are even having a major moment as designers revive a ’90s aesthetic. Frank’s colorful and psychedelic artistry can be found on a number of things from pajama sets to prepaid debit cards, and even the new design of Rebook’s Classic Leather sneaker.

Check out a list of all the oldies-but-goodies making a big comeback in 2017 and 2018 below:

Will & Grace: The series originally ran on NBC from 1998 to 2006. The reboot will see besties Will, Grace, Karen and Jack running amok in New York City, just as they used to before the series finale, in which Will and Grace were happily married to their respective partners and with children. Showrunners are