be coming to an end, with Tony Pulis one of several admirers thought to be willing to give the former England man more game time. Hughes likes a striker and is thought to be keeping tabs, along with much of the rest of Europe, on Wolfsburg’s Bas Dost. Paul Wilson

Top target Yevhen Konoplyanka (Dnipro, free agent), Bas Dost (Wolfsburg), Sandro (Barcelona)

May end up with Charlie Austin (QPR)

Transfer kitty Up to £20m but not all on one player

Already signed Jakob Haugaard (FC Midtjylland), Philipp Wollscheid (Bayer Leverkusen)

Southampton



Southampton may have to replace much of the rearguard that excelled last season. Toby Alderweireld’s loan from Atlético Madrid expires so the club will either have to activate their option to buy the centre-back – who may prefer to join an even bigger[Two cases of heterozygous Fabry disease].
We report two cases of heterozygous Fabry disease with severe organ damage. Case 1 was a 47-year-old woman. In April 1977, at the age of 27 years, she had proteinuria and edema around the 26th week of her second pregnancy and was diagnosed as toxicosis of pregnancy. She had proteinuria after the delivery. In 1990, a renal biopsy showed zebra bodies under electron microscopic findings, and the patient was diagnosed as Fabry disease. In 1998, a myocardial biopsy showed identical findings. The patient developed severe hypertension and decreased renal function, and alpha-galactosidase enzyme replacement therapy was initiated. However, despite treatment, she was started on dialysis in 2004. Case 2 was a 40-year-old woman. In March 2003, the patient presented with severe hypertension. The