of “Debt, the IMF, and the World Bank, Sixty Questions, Sixty Answers”, Monthly Review Press, New York, 2010. He has published extensively in this field. He is a member of the Fourth International leadership.performed by evolution. In fact, like the pair enzyme/substrate, pairs of complementary LES have evolved through millions of years in order to learn how to recognize its partners as well as to avoid aggregation, II) it is unlikely that the protein can develop drug–resistance through mutations as LES are stabilized by hot amino acids.

The present paper is divided in two main parts. A theoretical one (Sections 2 and 3) where the prediction of the model are presented, and an experimental one (Sect. 4), where the properties of the designed inhibitor are tested.

Folding units of HIV–1–PR: Local Elementary Structures
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The first step to be taken in the design of an inhibitor of the HIV–1–PR following the strategy discussed in the previous Section is to determine the LES of the target