350-560 ml. This is consistent with the central hypoventilation where the tidal volume with resultant effect on minute ventilation varies between sleep and wakefulness, being lowest in non-REM sleep in CCHS, but it is also abnormal during REM sleep and wakefulness, although usually to a milder degree sleep.

During the polysomnography conducted in the ICU, the patient showed evidence of hypoventilation and high PCO2 which was detected promptly after 45 minutes in first trial and 10 minutes in the second) and patient was connected back to the ventilator to prevent further Oxygen desaturation.(hypnogram1)

The patient had prolonged hospital course.The total hospital length of stay was 113 days, out of which 97 days were spent in the intensive care unit. She was mechanically ventilated, mostly at night for 65 days. TracheostomyFLG P478S polymorphisms and environmental risk factors for the atopic march in Taiwanese children: a prospective cohort study.
Little is known about the role of genetic and environmental modifiers in atopic march. To investigate the effects of filaggrin (FLG) P478S polymorphisms and environmental factors on the risk of asthma in a cohort of children with atopic dermatitis (AD). In 2010, 3,246 children from Childhood Environment and Allergic Diseases Cohort Study cohort were recruited. There were 485 children with AD who were invited for further clinical evaluation. Environmental exposures and skin prick tests for allergens were collected at 3 years of age and the development of asthma was determined at 6 years. Multivariate logistic regressions were performed to estimate the association between genetic and environmental factors and the development asthma