regard to jurisdictional claims in published maps and institutional affiliations.

The authors wish to thank P. Vaghi, Centro Grandi Strumenti Università di Pavia, for technical assistance to confocal microscopy.

EB, PP and IG carried out cell culture and transfection experiments; HCR experiments were performed by EB; immunofluorescence experiments were performed by PP and EB. Flow cytometry analysis was carried out by EP. EP, LAS and OC wrote the manuscript. All the authors contributed to the design of the project. All the authors have read and approved the manuscript.

This research was supported by a Grant from the Italian Ministry of Education, University and Research (MIUR) to the Department of Molecular Medicine of the University of Pavia under the initiative "Dipartimenti di Eccellenza (2018--2022)". This work was in part supported by AIRC[New end of life's approach: law of April 22, 2005 and decrees of February 6, 2006].
Further to a national debate, extremely mediatized, the law of April 22, 2005 relating to the rights of the patients and the end of life, was adopted. This law brings new rights to the patients and clarifies the medical practice concerning situations of end of life. Physicians have to refrain from any unreasonable stubbornness in investigations or therapeutics and they can give up beginning or pursue treatments which seem useless, disproportionate or which have the other object or effect than the artificial preservation of the life. Pain's relief is a right of the patient. Physicians can, with the aim of relieving the suffering of a end of life's person, give a treatment being