than traditional media outlets to changing consumer tastes, and that it could have trouble reaching older demographics.

Snapchat reaches 35 percent of all Americans, according to research firm MoffettNathanson's report, but that reach is concentrated among younger users.

During the fourth quarter of 2016, Snapchat reached 70 percent of 18- to 24-year-olds, but just 23 percent of people over 35.

By comparison, Facebook reached 88 percent of people over 35 during the same period. Instagram reached 45 percent and Twitter 42 percent of that age group.

Still, Snapchat's reach for those older users is up from just 8 percent at the beginning of 2016, suggesting that segment is growing.

Meanwhile, 58 percent of Snapchat's daily active users, a key metric for advertisers, are between the ages of 13 and 24, according to theof labeled oligonucleotides containing two fixed positions and six degenerate positions is hybridized to the template. The primer hybridizes to the adaptor. Each pool consists of 16,384 different sequences. Four fluorescent dyes are used to label the oligonucleotides in a pool in a fashion that creates four subsets from the sixteen combinations at the two fixed positions. Thus, each fluorescent tag is associated with four of the sixteen possible combinations. Following hybridization, a ligase is added and any probes in the pool that hybridized contiguously with the primer are ligated to the primer. The fluorescence of the hybridized and ligated product is determined. The fluorescence defines which subset of sequences hybridized to the template and ligated to the primer. The terminal three bases and the associated fluorescent tag