evaluated for the safety population. A TEAE was defined as an AE that occurred after the first dose of study medication that was not evident before treatment, or worsening of an AE that was present before start of treatment. Treatment-emergent adverse events were classified into mild/moderate and severe groups, as determined by the investigator. Serious AEs were reported based on the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) criteria. Discontinuation rates due to AEs were also evaluated.

Statistical methods
-------------------

Mean changes from baseline to endpoint in all symptoms were compared by analysis of covariance ([ancova]{.smallcaps}) for each OAB outcome, with treatment and centre as terms and baseline as a covariate. Treatment group comparisons of 'responder' or 'normalisation' rates were based on Fisher\'s#unlikelyNRLheadlines — Andrew Ferguson (@AndrewRLP) August 12, 2014

Paul Gallen plays 3 straight games for the Sharks #unlikelynrlheadlines — Strike Punting (@strikepunting) August 12, 2014

@Former_legend Paul Gallen elected mayor of QLD unopposed #unlikelyNRLheadlines — Greg Flack (@gflack77) August 12, 2014

Broncos not playing on a Friday night #UnlikelyNRLHeadlines — Simon (@simonpie97) August 12, 2014

South Sydney win the comp #unlikelyNRLheadlines — Jay Darnell (@jDARNELL96) August 12, 2014

Sharks trophy cabinet collapses under massive weight. #unlikelyNRLheadlines — Former Legend (@Former_legend) August 12, 2014

Can't wait to see the Adelaide game this weekend #unlikelyNRLheadlines — Andrew O'Leary (@andrewoleary) August 13, 2014

#unlikelyNRLheadlines Roosters have a crowd at home game — Graeme Cotton (@BulldogCotton) August 13, 2014

Cameron Smith accepts referees decision without dummy spit. #unlikelyNRLheadlines — Luke Smith (@LGsmith1123) August 12, 2014

Of course, the best tweets were