The feasibility would be explored of extending the quantitative histological study of the rat gastric mucosa to include investigation of cGMP, along with the cAMP as originallly planned, in order to clarify their separate, and possibly interrelated roles, in the various histological zones. If feasible to determine both cGMP and cAMP simultaneously in the same microtome section tissue sample, the effects on the cGMP and cAMP levels in the histological regions of the gastric mucosa of in vivo treatments to stimulate and inhibit secretion would be followed, instead of the study of cAMP alone. Histidine, the precursor, and pyridoxal PO4, the decarboxylase coenzyme, of the histamine synthesizing system would also be measured in the histological regions under the conditions and following the drug treatments, as above, in the  Claims
Solutions,

                Petitioner,

           v.

SHIRLEY ADDISON, widow of Jerry Addison, deceased; DIRECTOR,
OFFICE OF WORKERS’ COMPENSATION PROGRAMS, UNITED STATES
DEPARTMENT OF LABOR,

                Respondents.



On Petition for Review of an Order of the Benefits Review Board.
(14-0019 BLA)


Argued:   December 9, 2015                    Decided:   July 29, 2016


Before NIEMEYER, DUNCAN, and AGEE, Circuit Judges.


Petition for review granted; order vacated and remanded by
published opinion. Judge Agee wrote the opinion, in which Judge
Niemeyer and Judge