The human IgA-Fc alpha receptor interaction and its blockade by streptococcal IgA-binding proteins.
IgA plays a key role in immune defence of the mucosal surfaces. IgA can trigger elimination mechanisms against pathogens through the interaction of its Fc region with Fc alpha Rs (receptors specific for the Fc region of IgA) present on neutrophils, macrophages, monocytes and eosinophils. The human Fc alpha R (CD89) shares homology with receptors specific for the Fc region of IgG (Fc gamma Rs) and IgE (Fc epsilon RIs), but is a more distantly related member of the receptor family. CD89 interacts with residues lying at the interface of the two domains of IgA Fc, a site quite distinct from the homologous regions at the top of IgG and IgE Fc recognized by Fc gammaIn 1902, the largest, fastest sailing
ship the world had ever seen was launched. The legendary Preussen
dominated the seas, only to be gone in a few short years. Neither before
nor since has the world seen such a magnificent sailing ship.

Until today…

The largest true fully rigged
sailing ship in the world.

Inspired by the legendary Tall Ship, Preussen, the new
Royal Clipper has the proud distinction of being the largest and only
five-masted sailing ship built since her predecessor was launched at
the beginning of the last century. With her complement of 42 sails,
Royal Clipper is a splendid sight to behold. You might think she was
an apparition from the grand age of sail, but Royal Clipper is as new
as tomorrow. She boasts state-of-the-art navigation systems and all
the comforts of today.

For connoisseurs of sail cruising, the