Marines to invade Nicaragua (again), occupying it until 1933.

1931 -- The US invades Guatemala (again), to establish a servile government.

1961 -- CIA-backed coup overthrows elected Pres. J. M. Velasco Ibarra of Ecuador, because he has been too friendly with Cuba.

1970 -- Salvador Allende is elected in Chile. He suspends foreign loans and nationalizes foreign companies. For the phone system, Chile pays ITT the company's minimized valuation for tax purposes. The CIA provides covert financial support for Allende's opponents, both during and after his election.and Leticia Evans, Program Coordinator, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, for reading of the manuscript.

The authors declare no conflict of interest.

![Exosome biogenesis, cargo sorting, and release. Illustration of loading into exosomes of cargo such as nucleic acid and proteins. Endocytosis of the plasma membrane (**A**) results in the uptake of proteins, nucleic acids, and membrane-associated molecules, and formation of the early endosome (EE) (**B**); Upon transformation of the early endosome into the late endosome (LE) (**C**), exosomes are formed by inward budding of the late endosome/multivesicular body (MVB) with the content in a similar orientation as in the plasma membrane (**D**); Fusion of the MVB with the plasma membrane allows for the release of exosomes into the extracellular space (**E**); Alternatively,