storage of the active substance up to the procedure and during the course of pharmaceutical dosage form production have an influence on the percent of impurities and degradation products of the active substance. At the same time, pharmaceutical excipients comprised in the pharmaceutical dosage form have an influence on the percent of degradation products and impurities in the active substance. Said pharmaceutical excipients are selected from the group consisting of fillers or diluents, binders, lubricants, glidants, disintegrants, colorants, flavors, adsorbents, plasticizers and the like.
Not only an active substance undergoes degradation by environmental influences but also excipients in a pharmaceutical dosage form may be degraded. Degradation products of the latter act as the reactive sites which trigger degradation reactions of the active substance in a pharmaceutical dosage form.
Among theSyria protests: More than 2,900 killed overall, says UN Published duration 6 October 2011

image caption Many protesters are calling for the overthrow of President Assad

The death toll in Syria has risen to more than 2,900 people since the pro-democracy protests began in March, the United Nations human rights office has said.

The UN had previously put the death toll at 2,700.

On Tuesday, the UN Security Council failed to agree a resolution on taking action against Syria.

Opposition activists said 16 people died in different parts of the country on Wednesday as protests continued.

President Bashar al-Assad has cracked down on them, blaming the unrest on "terrorists and armed gangs".

But he announced that local elections would be held in December.

Correspondents say this is unlikely to be acceptable to the protesters.

Many of them