days after stroke, the mouse performance and spontaneous motor remapping was evaluated on the M-Platform for 5 days a week along 4 more weeks. The results from the first week 1 month after the injury is the so-called "stroke" condition, while the results during the last week, when the animal recovers the motor function is referred to as "rehab."

Each day, the beginning of the wide-field imaging session was triggered by the start of the training session on the M-Platform. To detect the movement of the wrist of the animal in the low-light condition of the experiment, an infrared (IR) emitter was placed on the linear slide, and rigidly connected to the load cell and thus to the animal\'s wrist. Slide displacement was recorded by an IR camera (EXISare active when there is also a force recorded, and conversely, there is low activation when the slide is still. It is also worth mentioning that, although the two muscles receive the same inputs from the descending stimuli, their activation levels are different due to the feedback circuitry of the spinal cord and the activity of muscle spindles, which are different for the two muscles. Thus, the output of the spinal cord circuitry is not a mere filtering of the input signals, but it also takes into account the feedback from the embodiment, which can change during the experiment. This effect underlies the importance of embedding neural circuits in a proper, realistic embodiment. The comparison between the simulated slide position and the recorded one shows that, thanks to