This area was inhabited by the Inuit people in the past, but in present times King Frederick VI Coast is uninhabited.
Numerous coastal islands, including Qulleq, Timmiarmiit, Griffenfeld Island and Skjoldungen, have recent Inuit remains, as well as Paleo-Eskimo or ancient Thule culture sites.

Icelander Gunnbjørn Ulf-Krakason  reportedly sighted the eastern coast of Greenland in the 10th century.
The inhabitants of the Western Settlement referred to the inhospitable Southeastern Greenland coast as "Ubygder", the unbuilt place.
In 1001 Torgils Orrabeinfostre, a legendary Norseman who was shipwrecked in these harsh shores, spent four years trying to reach the Western Settlement.

Later, in the 18th century, Peder Olsen Walløe was the first European known with certainty to have landed on the still uncharted southern part of the coast using local umiak boats.

Wilhelm August Graah (1793–1863), a Danish naval officer, was sent by the King of Denmark on an expedition to the little known eastern coast with the purpose to search for the lost Eastern Norse Settlement.
Like Walløe, Graah also used local umiaks and mapped parts of the area for the first time, naming the coast "King Frederick VI Coast".
He made numerous contacts with the now extinct Southeast-Greenland Inuit during his 1828–30 expedition, describing some of their customs and way of life in the harsh living conditions of the coast.

In 1883-85 Gustav Holm and Vilhelm Garde made a more thorough survey of the coast, completing the mapping of the region begun by Graah.

In 1931 Gino Watkins, leader of the 1930-1931 British Arctic Air Route Expedition, together with Percy Lemon and Augustine Courtauld traveled southwards along the little explored King Frederick VI Coast all the way south on a gruesome open boat journey of 600 nautical miles (1,111 km) using two small whaleboats and a kayak.

Braving harsh weather conditions, the three boats managed to round Cape Farewell, reaching finally Nanortalik on the western side.

In 1931 Norway claimed sovereignty over a section of the coast between 60°30'N —just north of Nanuuseq, and 63°40'N —just south of Odinland.
On 12 July 1932, acting leader Finn Devold was required by the Norwegian government to formally hoist the Norwegian flag at Finnsbu, the main Norwegian station in the area.
Following the 1933 resolution of the Permanent Court of International Justice rejecting Norway's claims in Greenland, Finnsbu was abandoned, but the Torgilsbu station continued operation until 1940.

Knud Rasmussen visited the coast in 1931, in the course of his Sixth Thule Expedition and again in 1932 and 1933 in the Seventh Thule Expedition, contributing greatly to the cartography of the inner fjords and mountain ranges.
He also explored the possibility of establishing a new Greenlandic settlement in the coast, which was by then depopulated.

In 1938 one hundred and fifty Inuit from Ammassalik were convinced by the Danish authorities to settle in Skjoldungen's western shore.
For a few years there was a populated place in the King Frederick VI Coast, until 1965 when the inhabitants were relocated and the settlement was abandoned.
This area was inhabited by the Inuit people in the past, but in present times King Frederick VI Coast is uninhabited. Numerous coastal islands, including Qulleq, Timmiarmiit, Griffenfeld Island and Skjoldungen, have recent Inuit remains, as well as Paleo-Eskimo or ancient Thule culture sites.
Icelander Gunnbjørn Ulf-Krakason  reportedly sighted the eastern coast of Greenland in the 10th century. The inhabitants of the Western Settlement referred to the inhospitable Southeastern Greenland coast as "Ubygder", the unbuilt place. In 1001 Torgils Orrabeinfostre, a legendary Norseman who was shipwrecked in these harsh shores, spent four years trying to reach the Western Settlement.
Later, in the 18th century, Peder Olsen Walløe was the first European known with certainty to have landed on the still uncharted southern part of the coast using local umiak boats. 
Wilhelm August Graah (1793–1863), a Danish naval officer, was sent by the King of Denmark on an expedition to the little known eastern coast with the purpose to search for the lost Eastern Norse Settlement. Like Walløe, Graah also used local umiaks and mapped parts of the area for the first time, naming the coast "King Frederick VI Coast". He made numerous contacts with the now extinct Southeast-Greenland Inuit during his 1828–30 expedition, describing some of their customs and way of life in the harsh living conditions of the coast.
In 1883-85 Gustav Holm and Vilhelm Garde made a more thorough survey of the coast, completing the mapping of the region begun by Graah.
In 1931 Gino Watkins, leader of the 1930-1931 British Arctic Air Route Expedition, together with Percy Lemon and Augustine Courtauld traveled southwards along the little explored King Frederick VI Coast all the way south on a gruesome open boat journey of 600 nautical miles (1,111 km) using two small whaleboats and a kayak.
Braving harsh weather conditions, the three boats managed to round Cape Farewell, reaching finally Nanortalik on the western side.
In 1931 Norway claimed sovereignty over a section of the coast between 60°30'N —just north of Nanuuseq, and 63°40'N —just south of Odinland. On 12 July 1932, acting leader Finn Devold was required by the Norwegian government to formally hoist the Norwegian flag at Finnsbu, the main Norwegian station in the area. Following the 1933 resolution of the Permanent Court of International Justice rejecting Norway's claims in Greenland, Finnsbu was abandoned, but the Torgilsbu station continued operation until 1940.
Knud Rasmussen visited the coast in 1931, in the course of his Sixth Thule Expedition and again in 1932 and 1933 in the Seventh Thule Expedition, contributing greatly to the cartography of the inner fjords and mountain ranges. He also explored the possibility of establishing a new Greenlandic settlement in the coast, which was by then depopulated.
In 1938 one hundred and fifty Inuit from Ammassalik were convinced by the Danish authorities to settle in Skjoldungen's western shore. For a few years there was a populated place in the King Frederick VI Coast, until 1965 when the inhabitants were relocated and the settlement was abandoned.
King Frederick VI Coast