The squadron was redesignated the 741st Strategic Missile Squadron and activated on 1 December 1962 as an intercontinental ballistic missile squadron at Minot Air Force Base, North Dakota.
 The squadron was initially equipped with 50 LGM-30B Minuteman Is, and placed its first missile on alert in 1963.
  The 741st upgraded to the LGM-30G Minuteman III and on 19 August 1970 was the first unit to place a Minuteman III on alert status.
It has maintained ICBMs on alert ever since.

The squadron has undergone several changes in assignment that did not affect its mission.
 In June 1968, the 455th Strategic Missile Wing at Minot was replaced by the 91st Strategic Missile Wing, which moved from Glasgow Air Force Base, Montana to Minot on paper, and the squadron was reassigned to the 91st Wing.
In September 1991 Strategic Air Command (SAC) reorganized its combat wings under the combat wing organization, and the 91st Wing's missile squadrons were assigned to the reactivated 91st Operations Group.
In 1992, the Air Force reorganized its combat forces.
 SAC was inactivated and the squadron became an element of Air Combat Command until July 1993, when it became part of Air Force Space Command.
Between 1994 and 1996, the wing was reduced to group level.
In December 2009, the Air Force's nuclear capable missile units, including the 741st, were transferred to Air Force Global Strike Command.

Squadron missile sites are designated by flight, using one letter of the alphabet, followed by a number.
The first site in each flight is No.
1 and designates the Missile Alert Facility, which consists of an above-ground structure plus an underground launch control center staffed by two officers.
The launch facilities, are numbered 2 through 11 and are connected to the launch control center by hardened intersite cables, which also interconnect flights.
The 741st includes flights F through J.
The 741st became the first unit in Twentieth Air Force to operate the LCC NetLink computer system.
 This system allows missile combat crew members access to remote monitoring systems (including security and weather monitoring systems), automated maintenance systems, training materials and other items on Minot's local area network while on alert.
Prior to NetLink, no external communication systems, aside from telephone, was allowed into the launch control center.
The squadron was redesignated the 741st Strategic Missile Squadron and activated on 1 December 1962 as an intercontinental ballistic missile squadron at Minot Air Force Base, North Dakota.  The squadron was initially equipped with 50 LGM-30B Minuteman Is, and placed its first missile on alert in 1963.   The 741st upgraded to the LGM-30G Minuteman III and on 19 August 1970 was the first unit to place a Minuteman III on alert status. It has maintained ICBMs on alert ever since.
The squadron has undergone several changes in assignment that did not affect its mission.  In June 1968, the 455th Strategic Missile Wing at Minot was replaced by the 91st Strategic Missile Wing, which moved from Glasgow Air Force Base, Montana to Minot on paper, and the squadron was reassigned to the 91st Wing. In September 1991 Strategic Air Command (SAC) reorganized its combat wings under the combat wing organization, and the 91st Wing's missile squadrons were assigned to the reactivated 91st Operations Group. In 1992, the Air Force reorganized its combat forces.  SAC was inactivated and the squadron became an element of Air Combat Command until July 1993, when it became part of Air Force Space Command. Between 1994 and 1996, the wing was reduced to group level. In December 2009, the Air Force's nuclear capable missile units, including the 741st, were transferred to Air Force Global Strike Command.
Squadron missile sites are designated by flight, using one letter of the alphabet, followed by a number. The first site in each flight is No. 1 and designates the Missile Alert Facility, which consists of an above-ground structure plus an underground launch control center staffed by two officers. The launch facilities, are numbered 2 through 11 and are connected to the launch control center by hardened intersite cables, which also interconnect flights. The 741st includes flights F through J.
The 741st became the first unit in Twentieth Air Force to operate the LCC NetLink computer system.  This system allows missile combat crew members access to remote monitoring systems (including security and weather monitoring systems), automated maintenance systems, training materials and other items on Minot's local area network while on alert. Prior to NetLink, no external communication systems, aside from telephone, was allowed into the launch control center.
741st Missile Squadron