Duke of Milan Francesco I Sforza ordered the construction of a Dominican convent and church at the site of a prior chapel dedicated to the Marian devotion of St Mary of the Graces.
The main architect, Guiniforte Solari, designed the convent (the Gothic nave), which was completed by 1469.
Construction of the church took decades.
Duke Ludovico Sforza decided to have the church serve as the Sforza family burial site, and rebuilt the cloister and the apse, both completed after 1490.
Ludovico's wife Beatrice was buried in the church in 1497.

The design of the apse of the church has been attributed to Donato Bramante, as his name is inscribed in a piece of marble in the church vaults delivered in 1494.
However, some dispute that he worked on the church at all.
According to one source, in 1492–1497 Bramante worked on the crossing and the dome as well the transept apses and the coir with apse; this source also attributes a plan and section of the building to Bramante.
Some documents mention the name Amadeo, likely Giovanni Antonio Amadeo.
Similarities between this church and Amadeo's design for Santa Maria alla Fontana make this attribution more likely.

In 1543, the Titian altarpiece depicting Christ receiving the crown of thorns was installed in  the Chapel of the Holy Crown, located on the right of the nave.
The painting, looted by French troops in 1797, is now in the Louvre.
This chapel is frescoed with Stories of the Passion by Gaudenzio Ferrari.
In the small cloister adjacent to the tribune near the door that leads to the sacristy is a fresco by Bramantino.
The church also contained frescoes depicting the Resurrection and Passion by Bernardo Zenale.

Composer and cellist Giovanni Perroni served as maestro di cappella at the cathedral from 1718–1720.
Duke of Milan Francesco I Sforza ordered the construction of a Dominican convent and church at the site of a prior chapel dedicated to the Marian devotion of St Mary of the Graces. The main architect, Guiniforte Solari, designed the convent (the Gothic nave), which was completed by 1469. Construction of the church took decades. Duke Ludovico Sforza decided to have the church serve as the Sforza family burial site, and rebuilt the cloister and the apse, both completed after 1490. Ludovico's wife Beatrice was buried in the church in 1497.
The design of the apse of the church has been attributed to Donato Bramante, as his name is inscribed in a piece of marble in the church vaults delivered in 1494. However, some dispute that he worked on the church at all. According to one source, in 1492–1497 Bramante worked on the crossing and the dome as well the transept apses and the coir with apse; this source also attributes a plan and section of the building to Bramante. Some documents mention the name Amadeo, likely Giovanni Antonio Amadeo. Similarities between this church and Amadeo's design for Santa Maria alla Fontana make this attribution more likely.
In 1543, the Titian altarpiece depicting Christ receiving the crown of thorns was installed in  the Chapel of the Holy Crown, located on the right of the nave. The painting, looted by French troops in 1797, is now in the Louvre. This chapel is frescoed with Stories of the Passion by Gaudenzio Ferrari. In the small cloister adjacent to the tribune near the door that leads to the sacristy is a fresco by Bramantino. The church also contained frescoes depicting the Resurrection and Passion by Bernardo Zenale.
Composer and cellist Giovanni Perroni served as maestro di cappella at the cathedral from 1718–1720.
Santa Maria delle Grazie, Milan