Sanders made his NFL debut in Week 1 against the Washington Redskins.
In the game, Sanders rushed 11 times for 25 yards as the Eagles won 32–27.
In Week 6 against the Minnesota Vikings, Sanders rushed three times for six yards and caught three passes for 86 yards and a touchdown in the 38-20 loss.
In a Week 15 game against the Redskins, Sanders rushed 19 times for 122 yards and a touchdown and caught six passes for 50 yards and a touchdown during the 37–27 win.
 During the game, Sanders passed LeSean McCoy and DeSean Jackson for the most rushing yards by a rookie and the most all-purpose yards by a rookie in franchise history, respectively.
 In Week 16 against the Dallas Cowboys, Sanders rushed 20 times for 79 yards and a touchdown and caught five passes for 77 yards during the 17–9 win.
 He finished his rookie season with  818 rushing yards and three rushing touchdowns to go along with 50 receptions for 509 receiving yards and three receiving touchdowns.

In the NFC Wild Card game against the Seattle Seahawks, Sanders rushed 14 times for 69 yards during the 17–9 loss.
Sanders made his NFL debut in Week 1 against the Washington Redskins. In the game, Sanders rushed 11 times for 25 yards as the Eagles won 32–27. In Week 6 against the Minnesota Vikings, Sanders rushed three times for six yards and caught three passes for 86 yards and a touchdown in the 38-20 loss. In a Week 15 game against the Redskins, Sanders rushed 19 times for 122 yards and a touchdown and caught six passes for 50 yards and a touchdown during the 37–27 win.  During the game, Sanders passed LeSean McCoy and DeSean Jackson for the most rushing yards by a rookie and the most all-purpose yards by a rookie in franchise history, respectively.  In Week 16 against the Dallas Cowboys, Sanders rushed 20 times for 79 yards and a touchdown and caught five passes for 77 yards during the 17–9 win.  He finished his rookie season with  818 rushing yards and three rushing touchdowns to go along with 50 receptions for 509 receiving yards and three receiving touchdowns.
In the NFC Wild Card game against the Seattle Seahawks, Sanders rushed 14 times for 69 yards during the 17–9 loss.
Miles Sanders