On July 25, 2008, Cypress Hill performed at a benefit concert at the House of Blues Chicago, where a majority of the proceeds went to the Chicago Alliance to End Homelessness.

In August 2009, a new song by Cypress Hill, titled "Get 'Em Up", was made available on iTunes.
The song is featured on the Madden NFL 2010 video game.

In November 2009, a new version of the Guns N' Roses classic "Paradise City" performed by Cypress Hill, Slash and Fergie was made available as a bonus track to Slash's single "Sahara" from Slash's solo album Slash.

Cypress Hill's eighth studio album Rise Up, features contributions from Everlast, Tom Morello, Daron Malakian, Pitbull, Marc Anthony and Mike Shinoda.
The album was released on Priority Records/EMI Entertainment, as the group was signed to the label by new Creative chairman Snoop Dogg on January 15, 2010.
The album was released on April 20, 2010.
The album's introduction single, "It Ain't Nothin'" was released as a free download from the group's official website.
The song "Rise Up" was featured at WWE's pay-per-view, Elimination Chamber, as the official theme song for that event, and was released as the third single for the album, with "Armada Latina" being fourth.
The song also appeared in the trailer of the movie The Green Hornet.

Cypress Hill commenced its Rise Up tour in Philadelphia on April 10, 2010.
Julio G had replaced DJ Muggs for the tour.
Muggs had been absent due to working on several other projects, including separate albums with B-Real and Sen Dog.
 The group was supposed to stop in Tucson, Arizona but canceled the show in protest of the recent immigration legislation.
At the Rock en Seine festival in Paris on August 27, 2010 they said in an interview that they would wait and see what happens with the legislation before going back there.
Cypress Hill performed at the Reading and Leeds Festivals in 2010, on August 28 at Leeds and August 29 at Reading.

On June 5, 2012, Cypress Hill and dubstep artist Rusko released a collaborative EP entitled Cypress X Rusko.
Also in 2012, Cypress Hill collaborated with Deadmau5 on his sixth studio album Album Title Goes Here, lending vocals on "Failbait".

In August 2017, Cypress Hill's "Ain't going out like that" was featured as a trailer soundtrack for Netflix's Narcos Season 3.

On September 28, 2018, Cypress Hill released the album Elephants on Acid, which saw the return of DJ Muggs as main composer and producer.

In April 2019 Cypress Hill received a star on the Hollywood Walk of Fame.
On July 25, 2008, Cypress Hill performed at a benefit concert at the House of Blues Chicago, where a majority of the proceeds went to the Chicago Alliance to End Homelessness.
In August 2009, a new song by Cypress Hill, titled "Get 'Em Up", was made available on iTunes. The song is featured on the Madden NFL 2010 video game.
In November 2009, a new version of the Guns N' Roses classic "Paradise City" performed by Cypress Hill, Slash and Fergie was made available as a bonus track to Slash's single "Sahara" from Slash's solo album Slash.
Cypress Hill's eighth studio album Rise Up, features contributions from Everlast, Tom Morello, Daron Malakian, Pitbull, Marc Anthony and Mike Shinoda. The album was released on Priority Records/EMI Entertainment, as the group was signed to the label by new Creative chairman Snoop Dogg on January 15, 2010. The album was released on April 20, 2010. The album's introduction single, "It Ain't Nothin'" was released as a free download from the group's official website. The song "Rise Up" was featured at WWE's pay-per-view, Elimination Chamber, as the official theme song for that event, and was released as the third single for the album, with "Armada Latina" being fourth. The song also appeared in the trailer of the movie The Green Hornet.
Cypress Hill commenced its Rise Up tour in Philadelphia on April 10, 2010. Julio G had replaced DJ Muggs for the tour. Muggs had been absent due to working on several other projects, including separate albums with B-Real and Sen Dog.  The group was supposed to stop in Tucson, Arizona but canceled the show in protest of the recent immigration legislation. At the Rock en Seine festival in Paris on August 27, 2010 they said in an interview that they would wait and see what happens with the legislation before going back there. Cypress Hill performed at the Reading and Leeds Festivals in 2010, on August 28 at Leeds and August 29 at Reading.
On June 5, 2012, Cypress Hill and dubstep artist Rusko released a collaborative EP entitled Cypress X Rusko. Also in 2012, Cypress Hill collaborated with Deadmau5 on his sixth studio album Album Title Goes Here, lending vocals on "Failbait".
In August 2017, Cypress Hill's "Ain't going out like that" was featured as a trailer soundtrack for Netflix's Narcos Season 3.
On September 28, 2018, Cypress Hill released the album Elephants on Acid, which saw the return of DJ Muggs as main composer and producer.
In April 2019 Cypress Hill received a star on the Hollywood Walk of Fame.
Cypress Hill