The Anhalt railway built by the Berlin-Anhalt Railway Company (Anhalter Bahn, BAE)  from Köthen and Dessau reached Wittenberg on 28 August 1841.
On 10 September 1841 the railway was consistently in operation as far as the Anhalt station in Berlin.
The first Wittenberg station was also built in 1841 on the former line to the north of the city wall.
It still exists today and is considered one of the oldest railway station building in Germany, but it is no longer used as such.
It is located on the street of Am Alten Bahnhof (“at the old station”).

The railway facilities were reorganised in 1859 during the construction of the first railway bridge over the Elbe on a direct line from Wittenberg to Bitterfeld, which was opened on 3 August 1859.
In the same year a new station building was built in the Swiss chalet style.
It was located on the town side of the railway tracks at about the 95.0 km point of the current chainage of the line.

The Wittenberg–Falkenberg (Elster) railway was opened by BAE on 15 October 1875.
Wittenberg had developed into a railway junction.
The third station of the town was opened at its current location on 13 November 1877.
The architect and builder was Franz Schwechten.

From 1888 to 1921, the station was connected to the town centre by a metre gauge horse railway.

The station was destroyed by Allied air raids on 16 and 20 April 1945.
Only the outer walls from the entrance building remained standing.
Reconstruction took place from 1948 and 1951.

Electric operations commenced on the Berlin–Halle railway in 1978 and on the Roßlau–Falkenberg railway in 1985.

In the spring of 1996, extensive remodelling of the station began as part of the German Unity Transport Projects (Verkehrsprojekts Deutsche Einheit): 8.3 (upgrading of the Berlin–Leipzig/Halle line).
Three platforms on the Berlin–Halle railway and a 42 m long pedestrian tunnel were completely rebuilt up to 1998.
While previously access to the station had only been possible by a road running between the tracks of the lines to Bitterfeld and Dessau, there has since been a direct western exit to the town.
The new bus station is located on the newly created station forecourt.
An electronic interlocking replaced several old signal boxes.
The new tracks have allowed trains to run through the station at up to 160 km/h since the construction of the new Elbe bridge.
The Anhalt railway built by the Berlin-Anhalt Railway Company (Anhalter Bahn, BAE)  from Köthen and Dessau reached Wittenberg on 28 August 1841. On 10 September 1841 the railway was consistently in operation as far as the Anhalt station in Berlin. The first Wittenberg station was also built in 1841 on the former line to the north of the city wall. It still exists today and is considered one of the oldest railway station building in Germany, but it is no longer used as such. It is located on the street of Am Alten Bahnhof (“at the old station”).
The railway facilities were reorganised in 1859 during the construction of the first railway bridge over the Elbe on a direct line from Wittenberg to Bitterfeld, which was opened on 3 August 1859. In the same year a new station building was built in the Swiss chalet style. It was located on the town side of the railway tracks at about the 95.0 km point of the current chainage of the line. 
The Wittenberg–Falkenberg (Elster) railway was opened by BAE on 15 October 1875. Wittenberg had developed into a railway junction. The third station of the town was opened at its current location on 13 November 1877. The architect and builder was Franz Schwechten.
From 1888 to 1921, the station was connected to the town centre by a metre gauge horse railway.
The station was destroyed by Allied air raids on 16 and 20 April 1945. Only the outer walls from the entrance building remained standing. Reconstruction took place from 1948 and 1951.
Electric operations commenced on the Berlin–Halle railway in 1978 and on the Roßlau–Falkenberg railway in 1985.
In the spring of 1996, extensive remodelling of the station began as part of the German Unity Transport Projects (Verkehrsprojekts Deutsche Einheit): 8.3 (upgrading of the Berlin–Leipzig/Halle line). Three platforms on the Berlin–Halle railway and a 42 m long pedestrian tunnel were completely rebuilt up to 1998. While previously access to the station had only been possible by a road running between the tracks of the lines to Bitterfeld and Dessau, there has since been a direct western exit to the town. The new bus station is located on the newly created station forecourt. An electronic interlocking replaced several old signal boxes. The new tracks have allowed trains to run through the station at up to 160 km/h since the construction of the new Elbe bridge.
Lutherstadt Wittenberg Hauptbahnhof