Following months of negotiation, the rematch with Klitschko was announced on 8 April 2016, this time with the fight scheduled to take place in Fury's hometown of Manchester at the Manchester Arena on 9 July 2016.
Despite agreeing terms for the rematch, Fury said he had "no motivation" and had gained an extreme amount of weight after the first fight, as he weighed over 330 pounds (150 kg) by April 2016.
On 24 June 2016, it was announced that this fight would be postponed to a later date due to Fury sustaining a sprained ankle in training.
On the same day, Fury and his cousin, Hughie Fury, were charged by UK Anti-Doping "with presence of a prohibited substance", namely nandrolone, from a sample taken 16 months previously in February 2015.
Tyson and Hughie said that they "strenuously deny" the charge.
On 23 September, Fury again postponed the fight after being declared "medically unfit".
ESPN reported that Fury had failed a drug test for cocaine a day before the second postponement.
Fury cited problems with depression after the positive test for cocaine.

Fury's mental health deteriorated after winning the world titles.
On 4 October 2016, in an interview with Rolling Stone, Fury said “I’m going through a lot of personal demons, trying to shake them off, this has got nothing to do with my fighting – what I’m going through right now is my personal life.
I've not been in a gym for months.
I've been going through depression.
I just don't want to live anymore, if you know what I’m saying.
I've had total enough of it.
Never mind cocaine.
I just didn't care.
I don't want to live anymore.
So cocaine is a little minor thing compared to not wanting to live anymore.
I am seeing help, but they can't do nothing for me.
What I've got is incurable.
I don't want to live.
All the money in the world, fame and glory, means nothing if you're not happy.
I'm seeing psychiatrists.
They say I've got a version of bipolar.
I'm a manic depressive.
I don't even want to wake up.
I hope I die every day.
And that's a bad thing to say when I've got three children and a lovely wife isn't it?
But I don't want to live anymore.
And if I could take me own life – and I wasn't a Christian – I'd take it in a second.
I just hope someone kills me before I kill me self.
I'll have to spend eternity in hell.
I’ve been out drinking, Monday to Friday to Sunday, and taking cocaine.
I can’t deal with it and the only thing that helps me is when I get drunk out of me mind."

On 12 October 2016, pending investigation on an anti-doping case about his cocaine use, nandrolone findings, and being deemed medically unfit to fight, Fury decided to vacate the WBA (Unified), WBO, IBO heavyweight titles.
He said "I won the titles in the ring and I believe that they should be lost in the ring, but I'm unable to defend at this time and I have taken the hard and emotional decision to now officially vacate my treasured world titles and wish the next in-line contenders all the very best as I now enter another big challenge in my life which I know, like against Klitschko, I will conquer."
Fury's promoter Mick Hennessy added: "Tyson will still be the lineal world heavyweight champion in everyone's eyes.
He beat the most dominant champion in the modern era of boxing on an amazing night in Germany to earn that accolade and that will never change.
Whilst it's heartbreaking to see Tyson vacate the world titles that he worked so long and hard for all his life, what's paramount now is that he receives the medical treatment along with the love of his family and friends and the support of the boxing world to make a full recovery."
Fury's decision was based on not having to put himself under constant media pressure, allowing him time to recover and receive professional medical help for his mental health problems, and spend time with his family.
On 13 October, the British Boxing Board of Control decided to suspend Fury's boxing licence.
On 1 February 2018, Fury was stripped of his last remaining title, The Ring magazine's heavyweight championship.
Following months of negotiation, the rematch with Klitschko was announced on 8 April 2016, this time with the fight scheduled to take place in Fury's hometown of Manchester at the Manchester Arena on 9 July 2016. Despite agreeing terms for the rematch, Fury said he had "no motivation" and had gained an extreme amount of weight after the first fight, as he weighed over 330 pounds (150 kg) by April 2016. On 24 June 2016, it was announced that this fight would be postponed to a later date due to Fury sustaining a sprained ankle in training. On the same day, Fury and his cousin, Hughie Fury, were charged by UK Anti-Doping "with presence of a prohibited substance", namely nandrolone, from a sample taken 16 months previously in February 2015. Tyson and Hughie said that they "strenuously deny" the charge. On 23 September, Fury again postponed the fight after being declared "medically unfit". ESPN reported that Fury had failed a drug test for cocaine a day before the second postponement. Fury cited problems with depression after the positive test for cocaine.
Fury's mental health deteriorated after winning the world titles. On 4 October 2016, in an interview with Rolling Stone, Fury said “I’m going through a lot of personal demons, trying to shake them off, this has got nothing to do with my fighting – what I’m going through right now is my personal life. I've not been in a gym for months. I've been going through depression. I just don't want to live anymore, if you know what I’m saying. I've had total enough of it. Never mind cocaine. I just didn't care. I don't want to live anymore. So cocaine is a little minor thing compared to not wanting to live anymore. I am seeing help, but they can't do nothing for me. What I've got is incurable. I don't want to live. All the money in the world, fame and glory, means nothing if you're not happy. I'm seeing psychiatrists. They say I've got a version of bipolar. I'm a manic depressive. I don't even want to wake up. I hope I die every day. And that's a bad thing to say when I've got three children and a lovely wife isn't it? But I don't want to live anymore. And if I could take me own life – and I wasn't a Christian – I'd take it in a second. I just hope someone kills me before I kill me self. I'll have to spend eternity in hell. I’ve been out drinking, Monday to Friday to Sunday, and taking cocaine. I can’t deal with it and the only thing that helps me is when I get drunk out of me mind."
On 12 October 2016, pending investigation on an anti-doping case about his cocaine use, nandrolone findings, and being deemed medically unfit to fight, Fury decided to vacate the WBA (Unified), WBO, IBO heavyweight titles. He said "I won the titles in the ring and I believe that they should be lost in the ring, but I'm unable to defend at this time and I have taken the hard and emotional decision to now officially vacate my treasured world titles and wish the next in-line contenders all the very best as I now enter another big challenge in my life which I know, like against Klitschko, I will conquer." Fury's promoter Mick Hennessy added: "Tyson will still be the lineal world heavyweight champion in everyone's eyes. He beat the most dominant champion in the modern era of boxing on an amazing night in Germany to earn that accolade and that will never change. Whilst it's heartbreaking to see Tyson vacate the world titles that he worked so long and hard for all his life, what's paramount now is that he receives the medical treatment along with the love of his family and friends and the support of the boxing world to make a full recovery." Fury's decision was based on not having to put himself under constant media pressure, allowing him time to recover and receive professional medical help for his mental health problems, and spend time with his family. On 13 October, the British Boxing Board of Control decided to suspend Fury's boxing licence. On 1 February 2018, Fury was stripped of his last remaining title, The Ring magazine's heavyweight championship.
Tyson Fury