Yeshivas Chachmei Lublin was, along with Daf Yomi, Shapiro's greatest achievement.
He conceived of a yeshiva for Hasidic Poland, modeled on Lithuanian yeshivas such as Volozhin, Slabodka and Novardok, but which would train Hasidic rabbis as the next generation to lead Polish Jewry.
The Yeshiva was housed in a massive building, housed hundreds of students, and had a vast library of over 100,000 books.

On May 22–28, 1924, the cornerstone laying ceremony took place for the construction of the yeshiva building.
Approximately 20,000 people participated in the event.
The opening ceremony took place on June 24–25, 1930.
Apart from thousands of local Jews, around 10,000 people arrived from all over Poland and abroad.

Shapiro served as rosh yeshiva until his death.
Yeshivas Chachmei Lublin was, along with Daf Yomi, Shapiro's greatest achievement. He conceived of a yeshiva for Hasidic Poland, modeled on Lithuanian yeshivas such as Volozhin, Slabodka and Novardok, but which would train Hasidic rabbis as the next generation to lead Polish Jewry. The Yeshiva was housed in a massive building, housed hundreds of students, and had a vast library of over 100,000 books.
On May 22–28, 1924, the cornerstone laying ceremony took place for the construction of the yeshiva building. Approximately 20,000 people participated in the event. The opening ceremony took place on June 24–25, 1930. Apart from thousands of local Jews, around 10,000 people arrived from all over Poland and abroad.
Shapiro served as rosh yeshiva until his death.
Meir Shapiro