The basic mechanism catalyzed by HATs involves the transfer of an acetyl group from acetyl-CoA to the ε-amino group of a target lysine side-chain within a histone.
 Different families of HATs employ unique strategies in order to effect such a transformation.
The basic mechanism catalyzed by HATs involves the transfer of an acetyl group from acetyl-CoA to the ε-amino group of a target lysine side-chain within a histone.  Different families of HATs employ unique strategies in order to effect such a transformation.
Histone acetyltransferase