The watershed of Mahoning Creek has an area of 39.6 square miles (103 km²).
It primarily drains the central portion of Montour County and is almost entirely in Montour County.
However, a small portion of the creek's watershed lies in the neighboring Columbia County.
The watershed makes up 30 percent of the area of Montour County.
Mahoning Creek drains the area in the vicinity of Danville.
The mouth of the creek is in the United States Geological Survey quadrangle of Riverside.
However, its source is in the quadrangle of Millville.
It also passes through the quadrangle of Danville.

47.15 percent of the watershed of Mahoning Creek consists of forested land.
36.47 percent of the watershed is agricultural land and 16.38 percent is developed land.
Most of the developed land is classified as "low-intensity development", but some is classified as "high-intensity development".
There are 7.4 acres of wetlands in the watershed.

Much of the land near the mouth of Mahoning Creek is developed.
A strip of land crossing the watershed in its central section is also developed.
The southernmost part of the watershed is largely agricultural land.
North of this is an area of mostly forested land and the central part of the watershed is mostly agricultural land.
The northern part includes both forested and agricultural land.
The fastest development in Montour County is occurring in the watershed of the creek.

Interstate 80 runs in an east-west direction through the watershed of Mahoning Creek.
There are also a number of township roads near the creek and its tributaries.
Pennsylvania Route 54, Pennsylvania Route 642, and US Route 11 are in the watershed as well.
The watershed of Mahoning Creek has an area of 39.6 square miles (103 km²). It primarily drains the central portion of Montour County and is almost entirely in Montour County. However, a small portion of the creek's watershed lies in the neighboring Columbia County. The watershed makes up 30 percent of the area of Montour County. Mahoning Creek drains the area in the vicinity of Danville. The mouth of the creek is in the United States Geological Survey quadrangle of Riverside. However, its source is in the quadrangle of Millville. It also passes through the quadrangle of Danville.
47.15 percent of the watershed of Mahoning Creek consists of forested land. 36.47 percent of the watershed is agricultural land and 16.38 percent is developed land. Most of the developed land is classified as "low-intensity development", but some is classified as "high-intensity development". There are 7.4 acres of wetlands in the watershed.
Much of the land near the mouth of Mahoning Creek is developed. A strip of land crossing the watershed in its central section is also developed. The southernmost part of the watershed is largely agricultural land. North of this is an area of mostly forested land and the central part of the watershed is mostly agricultural land. The northern part includes both forested and agricultural land. The fastest development in Montour County is occurring in the watershed of the creek.
Interstate 80 runs in an east-west direction through the watershed of Mahoning Creek. There are also a number of township roads near the creek and its tributaries. Pennsylvania Route 54, Pennsylvania Route 642, and US Route 11 are in the watershed as well.
Mahoning Creek (Susquehanna River tributary)