Lowassa served as Minister of State in the Prime Minister's Office during President Ali Hassan Mwinyi's second term.
He sought the nomination of Chama Cha Mapinduzi (CCM) as its presidential candidate in 1995 but was eliminated in the early stages by the former President Julius Nyerere, who strongly believed that Lowassa was not then correct material for the Presidency.
He retained his parliamentary seat and became a strong backbencher in Parliament until 1997 when he was appointed Minister for State in the Vice President's Office for Environment and Poverty.

Following the 2000 general elections, he was appointed Minister of Water and Livestock Development and made his mark as a hardworking minister.
In 2005 Lowassa chose not to seek the CCM presidential nomination but became a key campaigner for his long-time friend, Jakaya Kikwete, in his bid for the presidential seat.

Kikwete, running on a CCM ticket, won the elections by beating other contestants by a large margin.
He received 82% of the votes.
In return, President Kikwete nominated Lowassa as Prime Minister on 29 December 2005.
Parliament overwhelmingly confirmed the nomination, with 312 votes in favour and two opposed, and Lowassa was sworn in on 30 December.
Lowassa has an extensive background in both parliamentary and government affairs.
Lowassa served as Minister of State in the Prime Minister's Office during President Ali Hassan Mwinyi's second term. He sought the nomination of Chama Cha Mapinduzi (CCM) as its presidential candidate in 1995 but was eliminated in the early stages by the former President Julius Nyerere, who strongly believed that Lowassa was not then correct material for the Presidency. He retained his parliamentary seat and became a strong backbencher in Parliament until 1997 when he was appointed Minister for State in the Vice President's Office for Environment and Poverty.
Following the 2000 general elections, he was appointed Minister of Water and Livestock Development and made his mark as a hardworking minister. In 2005 Lowassa chose not to seek the CCM presidential nomination but became a key campaigner for his long-time friend, Jakaya Kikwete, in his bid for the presidential seat.
Kikwete, running on a CCM ticket, won the elections by beating other contestants by a large margin. He received 82% of the votes. In return, President Kikwete nominated Lowassa as Prime Minister on 29 December 2005. Parliament overwhelmingly confirmed the nomination, with 312 votes in favour and two opposed, and Lowassa was sworn in on 30 December. Lowassa has an extensive background in both parliamentary and government affairs.
Edward Lowassa