After the 2010–11 season, Cillessen was placed in the pre-selection for the senior Netherlands squad's friendly matches against Uruguay and Brazil.
Manager Bert van Marwijk eventually selected Cillessen for the Netherlands' friendly trip to South America.
On 7 May 2012, Cillessen was named in the provisional list of 36 players for the UEFA Euro 2012 tournament, one of nine uncapped players to be chosen by Van Marwijk as part of the preliminary squad.

On 7 June 2013, Cillessen obtained his first cap for the Netherlands national team under manager Louis van Gaal, after several call-ups in the past.
Cillessen played the first half in a friendly encounter against Indonesia in a 3–0 away win for the Dutch.
He was relieved in goal by Kenneth Vermeer in the 46th minute, as the two helped keep a clean sheet during their friendly encounter in Asia.

In June 2014, Cillessen was selected in the Netherlands' squad for the 2014 FIFA World Cup.
He was given the number 1 jersey and started in the team's opening match, a 5–1 victory against Spain in Salvador.
He went on to start in every match in the tournament as the Oranje took third place.
However, in the quarter-final against Costa Rica, Louis van Gaal unexpectedly substituted him for Tim Krul ahead of the penalty shootout, which the Dutch team won.
After the 2010–11 season, Cillessen was placed in the pre-selection for the senior Netherlands squad's friendly matches against Uruguay and Brazil. Manager Bert van Marwijk eventually selected Cillessen for the Netherlands' friendly trip to South America. On 7 May 2012, Cillessen was named in the provisional list of 36 players for the UEFA Euro 2012 tournament, one of nine uncapped players to be chosen by Van Marwijk as part of the preliminary squad.
On 7 June 2013, Cillessen obtained his first cap for the Netherlands national team under manager Louis van Gaal, after several call-ups in the past. Cillessen played the first half in a friendly encounter against Indonesia in a 3–0 away win for the Dutch. He was relieved in goal by Kenneth Vermeer in the 46th minute, as the two helped keep a clean sheet during their friendly encounter in Asia.
In June 2014, Cillessen was selected in the Netherlands' squad for the 2014 FIFA World Cup. He was given the number 1 jersey and started in the team's opening match, a 5–1 victory against Spain in Salvador. He went on to start in every match in the tournament as the Oranje took third place. However, in the quarter-final against Costa Rica, Louis van Gaal unexpectedly substituted him for Tim Krul ahead of the penalty shootout, which the Dutch team won.
Jasper Cillessen