As a teenager, Gilbert dated her Roseanne (and later The Big Bang Theory) co-star Johnny Galecki (their characters also dated).
During their relationship she realized she was a lesbian.
 She remains close friends with Galecki.

In 2001, Gilbert began a relationship with television producer Ali Adler.
They have two children—a son, Levi Hank, born to Adler in October 2004, and a daughter, Sawyer Jane, born to Gilbert in August 2007.
For many years, Gilbert remained private about her sexuality, choosing not to publicly discuss her personal life.
In July 2010, as she prepared to launch her talk show, The Talk, Gilbert confirmed that she was a lesbian.
In August 2011, Gilbert announced that she and Adler had separated amicably.

Following the breakup, Gilbert began a relationship with songwriter, music producer and former 4 Non Blondes frontwoman Linda Perry.
Gilbert announced their engagement in April 2013, and the pair married on March 30, 2014.
Gilbert gave birth to their son, Rhodes Emilio Gilbert Perry, on February 28, 2015.
On December 27, 2019, Gilbert filed for legal separation from Perry.
As a teenager, Gilbert dated her Roseanne (and later The Big Bang Theory) co-star Johnny Galecki (their characters also dated). During their relationship she realized she was a lesbian.  She remains close friends with Galecki.
In 2001, Gilbert began a relationship with television producer Ali Adler. They have two children—a son, Levi Hank, born to Adler in October 2004, and a daughter, Sawyer Jane, born to Gilbert in August 2007. For many years, Gilbert remained private about her sexuality, choosing not to publicly discuss her personal life. In July 2010, as she prepared to launch her talk show, The Talk, Gilbert confirmed that she was a lesbian. In August 2011, Gilbert announced that she and Adler had separated amicably.
Following the breakup, Gilbert began a relationship with songwriter, music producer and former 4 Non Blondes frontwoman Linda Perry. Gilbert announced their engagement in April 2013, and the pair married on March 30, 2014. Gilbert gave birth to their son, Rhodes Emilio Gilbert Perry, on February 28, 2015. On December 27, 2019, Gilbert filed for legal separation from Perry.
Sara Gilbert