When the War of the Spanish Succession began, the regiment took part in the 1702 Cádiz Landing; in 1703, it was sent to the West Indies, a notoriously unhealthy posting in an expedition that achieved very little.
Colonel Columbine died in June 1703, shortly before reaching Jamaica and was replaced by James Rivers.

The rest of the war was spent campaigning in Spain and Portugal, including Almansa in 1707 and the 1708 capture of Minorca.
In 1710, it fought at Almenar and Saragossa before being surrounded and captured at Brihuega.
After the 1713 Treaty of Utrecht, it was posted to Ireland and with the exception of the 1719 Vigo expedition, remained there until 1740.

In 1739, commercial tensions with Spain led to the War of Jenkins' Ear; in January 1741, the unit returned to the West Indies and took part in the expedition to Cartagena de Indias, modern Colombia.
The expeditionary force suffered losses of between 80-90% from dysentery and yellow fever.
The survivors returned to England in December 1742; the unit was brought up to strength as a result of the 1740–1748 War of the Austrian Succession, then sent to Scotland.
   
At the beginning of the Jacobite Rising in July 1745, detachments from the regiment garrisoned the line of forts between Inverness and Fort William.
Two companies were captured at the Battle of Prestonpans; some changed sides and executed as deserters in 1746.
Several companies defended Fort William in March 1746 and after Culloden, took part in the suppression of the Highlands.

The regiment remained in Scotland until 1753; it was transferred to Gibraltar, where it spent the next 19 years before moving to the West Indies in 1772.
On the outbreak of the American War of Independence, detachments from the 6th arrived in New York in 1776 and saw action, but were of insufficient strength and were sent home.
To aid recruiting, each infantry unit was linked with a county in 1782 and the 6th became the 6th (1st Warwickshire) Regiment.
During the French Revolutionary Wars in 1794 in the West Indies, the 6th took part in the invasions of Martinique, Guadeloupe and Saint Lucia from the French and in Casdebar, in August 1798, it gained a battle honour.
When the War of the Spanish Succession began, the regiment took part in the 1702 Cádiz Landing; in 1703, it was sent to the West Indies, a notoriously unhealthy posting in an expedition that achieved very little. Colonel Columbine died in June 1703, shortly before reaching Jamaica and was replaced by James Rivers.
The rest of the war was spent campaigning in Spain and Portugal, including Almansa in 1707 and the 1708 capture of Minorca. In 1710, it fought at Almenar and Saragossa before being surrounded and captured at Brihuega. After the 1713 Treaty of Utrecht, it was posted to Ireland and with the exception of the 1719 Vigo expedition, remained there until 1740.
In 1739, commercial tensions with Spain led to the War of Jenkins' Ear; in January 1741, the unit returned to the West Indies and took part in the expedition to Cartagena de Indias, modern Colombia. The expeditionary force suffered losses of between 80-90% from dysentery and yellow fever. The survivors returned to England in December 1742; the unit was brought up to strength as a result of the 1740–1748 War of the Austrian Succession, then sent to Scotland.    
At the beginning of the Jacobite Rising in July 1745, detachments from the regiment garrisoned the line of forts between Inverness and Fort William. Two companies were captured at the Battle of Prestonpans; some changed sides and executed as deserters in 1746. Several companies defended Fort William in March 1746 and after Culloden, took part in the suppression of the Highlands.
The regiment remained in Scotland until 1753; it was transferred to Gibraltar, where it spent the next 19 years before moving to the West Indies in 1772. On the outbreak of the American War of Independence, detachments from the 6th arrived in New York in 1776 and saw action, but were of insufficient strength and were sent home. To aid recruiting, each infantry unit was linked with a county in 1782 and the 6th became the 6th (1st Warwickshire) Regiment. During the French Revolutionary Wars in 1794 in the West Indies, the 6th took part in the invasions of Martinique, Guadeloupe and Saint Lucia from the French and in Casdebar, in August 1798, it gained a battle honour.
Royal Warwickshire Regiment