Heading out of Maidenhead town centre, the road follows Castle Hill and then Bath Road.
At the outskirts, the road forms part of junction 9b of the A404(M)/A404, which links junction 8/9 of the M4 with junction 4 of the M40 at Handy Cross.
 The A4 crosses open countryside before following New Bath Road on the outskirts of Twyford.
 This is a bypass, built in 1929, that deviates from the old route of the A4, and crosses the River Loddon on its way into the suburbs of Reading via the village of Charvil.

The A4 passes the King George's Field in Sonning, which are used as playing fields, and the Reading Cricket and Hockey Club.
 As it enters Reading, along the London Road again, it crosses the junction of the A3290 next to Palmer Park, which leads to Junction 10 of the M4.

The A4 goes over the intersection with the A329 Cemetery Junction which links Wokingham with Pangbourne, passing the Royal Berkshire Hospital and the London Road Campus of the University of Reading.
At London Street and again at Southampton Street, the A4 meets the A327 twice, since the latter loops round on two branches which meet at Whitley Street.
Between the two junctions, the A4 becomes Crown Street for approximately 150 metres.
Heading out of Maidenhead town centre, the road follows Castle Hill and then Bath Road. At the outskirts, the road forms part of junction 9b of the A404(M)/A404, which links junction 8/9 of the M4 with junction 4 of the M40 at Handy Cross.  The A4 crosses open countryside before following New Bath Road on the outskirts of Twyford.  This is a bypass, built in 1929, that deviates from the old route of the A4, and crosses the River Loddon on its way into the suburbs of Reading via the village of Charvil.
The A4 passes the King George's Field in Sonning, which are used as playing fields, and the Reading Cricket and Hockey Club.  As it enters Reading, along the London Road again, it crosses the junction of the A3290 next to Palmer Park, which leads to Junction 10 of the M4.
The A4 goes over the intersection with the A329 Cemetery Junction which links Wokingham with Pangbourne, passing the Royal Berkshire Hospital and the London Road Campus of the University of Reading. At London Street and again at Southampton Street, the A4 meets the A327 twice, since the latter loops round on two branches which meet at Whitley Street. Between the two junctions, the A4 becomes Crown Street for approximately 150 metres.
A4 road (England)