Platform 1 is on the north side of the station and the through platforms 13 and 14 are on the south side.
Of the terminus platforms,
Platforms 1-4 are typically used by eastbound services to Rose Hill, New Mills and Sheffield via the Hope Valley Line, services on the Glossop Line, and TransPennine Express services.

Platforms 5-9 are the longest and are used mainly by Avanti West Coast and CrossCountry services.

Platforms 10-12 are considerably shorter than the others and are usually used to accommodate local trains to Crewe and Manchester Airport, plus Mid-Cheshire line, Buxton Line and South Wales services; platform 12 is the shortest and can only accommodate three coaches.

The main entrance and concourse are to the front of the terminal platforms and the taxi and car drop-off entrance is on the southern side on Fairfield Street.
The Metrolink tram line passes under the station through the undercroft.
Its platforms are under the concourse and railway platforms.
To the south of Piccadilly, on the opposite side of Fairfield Street, is the derelict Manchester Mayfield station, which was closed for railway use in 1986.
Platform 1 is on the north side of the station and the through platforms 13 and 14 are on the south side. Of the terminus platforms,
Platforms 1-4 are typically used by eastbound services to Rose Hill, New Mills and Sheffield via the Hope Valley Line, services on the Glossop Line, and TransPennine Express services.
Platforms 5-9 are the longest and are used mainly by Avanti West Coast and CrossCountry services.
Platforms 10-12 are considerably shorter than the others and are usually used to accommodate local trains to Crewe and Manchester Airport, plus Mid-Cheshire line, Buxton Line and South Wales services; platform 12 is the shortest and can only accommodate three coaches.
The main entrance and concourse are to the front of the terminal platforms and the taxi and car drop-off entrance is on the southern side on Fairfield Street. The Metrolink tram line passes under the station through the undercroft. Its platforms are under the concourse and railway platforms. To the south of Piccadilly, on the opposite side of Fairfield Street, is the derelict Manchester Mayfield station, which was closed for railway use in 1986.
Manchester Piccadilly station