Friederike married Alexander Karl, Duke of Anhalt-Bernburg, son of Alexis Friedrich Christian, Duke of Anhalt-Bernburg and Princess Marie Friederike of Hesse-Kassel, on 30 October 1834 at Schloss Louisenlund, near Schleswig.
The union was childless.

By November 1855 the Duke was confined to Schloss Hoym due to a progressive mental illness (some sources state that he suffered from schizophrenia).
There, Alexander Karl spend the rest of his life under medical care in the company of his chamberlain, the painter Wilhelm von Kügelgen.
Due to his incapacity, Friederike acted as regent.
Friederike married Alexander Karl, Duke of Anhalt-Bernburg, son of Alexis Friedrich Christian, Duke of Anhalt-Bernburg and Princess Marie Friederike of Hesse-Kassel, on 30 October 1834 at Schloss Louisenlund, near Schleswig. The union was childless.
By November 1855 the Duke was confined to Schloss Hoym due to a progressive mental illness (some sources state that he suffered from schizophrenia). There, Alexander Karl spend the rest of his life under medical care in the company of his chamberlain, the painter Wilhelm von Kügelgen. Due to his incapacity, Friederike acted as regent.
Princess Friederike of Schleswig-Holstein-Sonderburg-Glücksburg