On December 9, 1846, Astor was married at Trinity Church in New York City to Charlotte Augusta Gibbes (February 27, 1825 – December 12, 1887).
Her parents were Thomas Stanyarne Gibbes Jr. and Susan Annette Vanden Heuvel.
Together, they had one child, William Waldorf Astor in 1848, who later became the 1st Viscount Astor, who married Mary Dahlgren Paul.

In 1859, he built a home at 338 Fifth Avenue, today the street address of the Empire State Building.
Later, he had an imposing vacation home, Beaulieu, built in Newport, Rhode Island, and he had a country estate, Nuits, at Ardsley-on-Hudson in Irvington, New York.
 Astor increasingly visited London in his later years.
His son moved there permanently with his family in 1891 and became a British citizen in 1899 later being made Lord Astor.

John Jacob Astor III died on February 22, 1890 and was interred in the Trinity Church Cemetery in Manhattan.
On December 9, 1846, Astor was married at Trinity Church in New York City to Charlotte Augusta Gibbes (February 27, 1825 – December 12, 1887). Her parents were Thomas Stanyarne Gibbes Jr. and Susan Annette Vanden Heuvel. Together, they had one child, William Waldorf Astor in 1848, who later became the 1st Viscount Astor, who married Mary Dahlgren Paul.
In 1859, he built a home at 338 Fifth Avenue, today the street address of the Empire State Building. Later, he had an imposing vacation home, Beaulieu, built in Newport, Rhode Island, and he had a country estate, Nuits, at Ardsley-on-Hudson in Irvington, New York.  Astor increasingly visited London in his later years. His son moved there permanently with his family in 1891 and became a British citizen in 1899 later being made Lord Astor.
John Jacob Astor III died on February 22, 1890 and was interred in the Trinity Church Cemetery in Manhattan.
John Jacob Astor III