Polyptych of the Misericordia (1445–62) –  Oil and tempera on panel, base 330 cm, height 273 cm, Museo Civico Sansepolcro
The Baptism of Christ (c. 1448–50) –  Tempera on panel, 168 × 116 cm, National Gallery, London
St. Jerome in Penitence (c. 1449–51) –  Oil on panel, 51 × 38 cm, Staatliche Museen, Berlin 
St. Jerome and a Donor (1451) –  Panel, 40 × 42 cm, Gallerie dell'Accademia, Venice
Sigismondo Pandolfo Malatesta Praying in Front of St. Sigismund (1451) –  Fresco, Tempio Malatestiano, Rimini
Portrait of Sigismondo Pandolfo Malatesta (c. 1451) –  Tempera and oil on panel, 44.5 × 34.5 cm, Musée du Louvre, Paris
The History of the True Cross (c. 1455–66) –  Frescoes, San Francesco, Arezzo
The Flagellation of Christ (c. 1460) –  Tempera on panel, 59 × 81.5 cm, Galleria Nazionale delle Marche, Urbino
Polyptych of Saint Augustine (1460–70) –  Oil and tempera on panel
Resurrection (c. 1463) – Fresco, 225 × 200 cm, Museo Civico Sansepolcro
Hercules (c. 1465) – Fresco, Isabella Stewart Gardner Museum, Boston
Madonna del parto (1459–67) –  Detached fresco, 260 × 203 cm, Chapel of the cemetery, Monterchi
The Nativity (c. 1470) –  124.5 × 123 cm, National Gallery, London
Polyptych of Perugia (c. 1470) –  Oil on panel, 338 × 230 cm, Galleria Nazionale dell'Umbria, Perugia
Madonna and Child with Saints (Montefeltro Altarpiece, (1472–74) –  Oil on panel, 248 × 170 cm, Pinacoteca di Brera, Milan 
Paired portraits (c. 1472) of Federico da Montefeltro and Battista Sforza, respectively the Duke and Duchess of Urbino –  Oil on panel, Galleria degli Uffizi, Florence.

Madonna di Senigallia (c. 1474) –  Oil on panel, 67 × 53.5 cm, Galleria Nazionale delle Marche, Urbino
Polyptych of the Misericordia (1445–62) –  Oil and tempera on panel, base 330 cm, height 273 cm, Museo Civico Sansepolcro
The Baptism of Christ (c. 1448–50) –  Tempera on panel, 168 × 116 cm, National Gallery, London
St. Jerome in Penitence (c. 1449–51) –  Oil on panel, 51 × 38 cm, Staatliche Museen, Berlin 
St. Jerome and a Donor (1451) –  Panel, 40 × 42 cm, Gallerie dell'Accademia, Venice
Sigismondo Pandolfo Malatesta Praying in Front of St. Sigismund (1451) –  Fresco, Tempio Malatestiano, Rimini
Portrait of Sigismondo Pandolfo Malatesta (c. 1451) –  Tempera and oil on panel, 44.5 × 34.5 cm, Musée du Louvre, Paris
The History of the True Cross (c. 1455–66) –  Frescoes, San Francesco, Arezzo
The Flagellation of Christ (c. 1460) –  Tempera on panel, 59 × 81.5 cm, Galleria Nazionale delle Marche, Urbino
Polyptych of Saint Augustine (1460–70) –  Oil and tempera on panel
Resurrection (c. 1463) – Fresco, 225 × 200 cm, Museo Civico Sansepolcro
Hercules (c. 1465) – Fresco, Isabella Stewart Gardner Museum, Boston
Madonna del parto (1459–67) –  Detached fresco, 260 × 203 cm, Chapel of the cemetery, Monterchi
The Nativity (c. 1470) –  124.5 × 123 cm, National Gallery, London
Polyptych of Perugia (c. 1470) –  Oil on panel, 338 × 230 cm, Galleria Nazionale dell'Umbria, Perugia
Madonna and Child with Saints (Montefeltro Altarpiece, (1472–74) –  Oil on panel, 248 × 170 cm, Pinacoteca di Brera, Milan 
Paired portraits (c. 1472) of Federico da Montefeltro and Battista Sforza, respectively the Duke and Duchess of Urbino –  Oil on panel, Galleria degli Uffizi, Florence.
Madonna di Senigallia (c. 1474) –  Oil on panel, 67 × 53.5 cm, Galleria Nazionale delle Marche, Urbino
Piero della Francesca