Central Station was built on the site of a former station known as Calhoun Street Station.
 Both stations were owned by the Illinois Central Railroad or its predecessors.
 Construction of Memphis Central Station began in September 1912, and the station was opened for service on October 4, 1914.
 The track design included five stub-end tracks (station tracks 1-5), and five through tracks (station tracks 6-10).

The station was also used by Yazoo and Mississippi Valley Railroad, St. Louis-San Francisco Railway, (also known as the Frisco) and Chicago, Rock Island and Pacific Railway (also known as Rock Island Railroad).
 Between April 1, 1964, and November 30, 1966, the Louisville and Nashville Railroad was also a tenant, during the time that Memphis Union Station was closed.

Lavender v. Kurn, 327 U.S. 645 (1946) was a case decided by the Supreme Court of the United States dealing with a negligent wrongful death case brought by the estate of an Illinois Central employee, a switchtender at Broadway Crossing.
 In December 1939, the switchtender had lined Frisco train #106 to back into Central Station.
 After the train passed, the switchtender was found fatally injured, although the cause could not with certainty be determined to be accidental from being hit by a RPO mail hook or being murdered by a hobo in the area.
 The relatives of the switchtender sued for negligence under the Federal Employers Liability Act and the Supreme Court upheld the claim.
Central Station was built on the site of a former station known as Calhoun Street Station.  Both stations were owned by the Illinois Central Railroad or its predecessors.  Construction of Memphis Central Station began in September 1912, and the station was opened for service on October 4, 1914.  The track design included five stub-end tracks (station tracks 1-5), and five through tracks (station tracks 6-10).
The station was also used by Yazoo and Mississippi Valley Railroad, St. Louis-San Francisco Railway, (also known as the Frisco) and Chicago, Rock Island and Pacific Railway (also known as Rock Island Railroad).  Between April 1, 1964, and November 30, 1966, the Louisville and Nashville Railroad was also a tenant, during the time that Memphis Union Station was closed.
Lavender v. Kurn, 327 U.S. 645 (1946) was a case decided by the Supreme Court of the United States dealing with a negligent wrongful death case brought by the estate of an Illinois Central employee, a switchtender at Broadway Crossing.  In December 1939, the switchtender had lined Frisco train #106 to back into Central Station.  After the train passed, the switchtender was found fatally injured, although the cause could not with certainty be determined to be accidental from being hit by a RPO mail hook or being murdered by a hobo in the area.  The relatives of the switchtender sued for negligence under the Federal Employers Liability Act and the Supreme Court upheld the claim.
Memphis Central Station