In 2011, Busch and Keselowski swapped teams and crews.
Busch took over a renumbered No.22 Dodge.
Busch earned his first Budweiser Shootout win after Denny Hamlin went below the yellow line at the end of the race at Daytona.
He would go on to win the 2011 Gatorade Duel 1, and because of polesitter Dale Earnhardt, Jr.'s crash in practice, which forced him into a backup car, Busch started in first for the 2011 Daytona 500 and started the 2011 season three for three.

Busch won the pole for and led most of the race at Kansas, for 152 laps.
However, a fuel pickup issue late hurt his chances of winning.
Teammate Brad Keselowski took the victory.
However, a few weeks later on June 26, Kurt finally got an elusive road course victory at Infineon Raceway.
Not only did he win, but he also led the most laps with 76.
Because of Brad Keselowski's injury during a practice crash at Road Atlanta, Busch filled in for Keselowski in his NASCAR Nationwide Series car for the Zippo 200 at Watkins Glen International, and Busch managed to get the pole and the win.
By August 13, 2011, Busch had won 1/4 of all of his Nationwide races.
On October 2, Busch won on two late restarts beating Jimmie Johnson in turn 1 leading the final 43 laps to grab his first-ever victory at the Monster Mile at Dover.
After a frustrating final five races, things came to a head when Busch launched a verbal tirade against an ESPN cameraman, and giving an obscene gesture to workers when a car blocked his path towards his pit garage following a transmission failure at the same race.
Crew chief Steve Addington moved to Stewart-Haas Racing after the 2011 season.

Busch's employment with Penske Racing was terminated on December 5, 2011.
 Although most observers of the sport believe he was fired, Busch claimed in a public statement that the parting was "mutual": "I am grateful to Penske Racing for six very productive years.
Together we won a lot of races – 16 in all. ...
Coming to a mutual agreement to go our separate ways is a positive step for me."
In contrast, the Charlotte Observer reported several sources confirming team owner Roger Penske decided that Busch's altercation at Homestead-Miami Speedway was the last straw in his stormy tenure with the team but chose to defer the announcement until after Champion's Week.
He was replaced in the No.
22 by A. J. Allmendinger.
Kurt Busch would later say in a 2019 podcast interview with Michael Waltrip that the dismissal was mostly because, following his engine blow-up in Homestead (in which a sharp piece of the engine had blown through the dashboard, almost injuring Busch), he was frustrated that the No.
22 team was unable to compete for championships, and he and Penske couldn't agree on whether the problem was the car or the driver.
However, Busch also said in the podcast that he is still friends with Penske.
In 2011, Busch and Keselowski swapped teams and crews. Busch took over a renumbered No.22 Dodge. Busch earned his first Budweiser Shootout win after Denny Hamlin went below the yellow line at the end of the race at Daytona. He would go on to win the 2011 Gatorade Duel 1, and because of polesitter Dale Earnhardt, Jr.'s crash in practice, which forced him into a backup car, Busch started in first for the 2011 Daytona 500 and started the 2011 season three for three.
Busch won the pole for and led most of the race at Kansas, for 152 laps. However, a fuel pickup issue late hurt his chances of winning. Teammate Brad Keselowski took the victory. However, a few weeks later on June 26, Kurt finally got an elusive road course victory at Infineon Raceway. Not only did he win, but he also led the most laps with 76. Because of Brad Keselowski's injury during a practice crash at Road Atlanta, Busch filled in for Keselowski in his NASCAR Nationwide Series car for the Zippo 200 at Watkins Glen International, and Busch managed to get the pole and the win. By August 13, 2011, Busch had won 1/4 of all of his Nationwide races. On October 2, Busch won on two late restarts beating Jimmie Johnson in turn 1 leading the final 43 laps to grab his first-ever victory at the Monster Mile at Dover. After a frustrating final five races, things came to a head when Busch launched a verbal tirade against an ESPN cameraman, and giving an obscene gesture to workers when a car blocked his path towards his pit garage following a transmission failure at the same race. Crew chief Steve Addington moved to Stewart-Haas Racing after the 2011 season.
Busch's employment with Penske Racing was terminated on December 5, 2011.  Although most observers of the sport believe he was fired, Busch claimed in a public statement that the parting was "mutual": "I am grateful to Penske Racing for six very productive years. Together we won a lot of races – 16 in all. ... Coming to a mutual agreement to go our separate ways is a positive step for me." In contrast, the Charlotte Observer reported several sources confirming team owner Roger Penske decided that Busch's altercation at Homestead-Miami Speedway was the last straw in his stormy tenure with the team but chose to defer the announcement until after Champion's Week. He was replaced in the No. 22 by A. J. Allmendinger. Kurt Busch would later say in a 2019 podcast interview with Michael Waltrip that the dismissal was mostly because, following his engine blow-up in Homestead (in which a sharp piece of the engine had blown through the dashboard, almost injuring Busch), he was frustrated that the No. 22 team was unable to compete for championships, and he and Penske couldn't agree on whether the problem was the car or the driver. However, Busch also said in the podcast that he is still friends with Penske.
Kurt Busch