The Montreal Children's Hospital (MCH) first opened on the rented premise of 500 Guy Street on January 30, 1904.
It was the first hospital in Montreal with the sole mandate of providing care for sick children.
In 1909, the growing number of patients required a move to new premises on Cedar Avenue, designed by David Robertson Brown (1869–1946).
In 1920, the hospital became a teaching hospital affiliated with McGill University.

The hospital has achieved a number of "firsts", including the first speech clinic in a pediatric hospital in 1933, the first division of medical genetics in 1949 and the first department of psychiatry in 1950.
The increasing number of services required another expansion.
 A relocation took place to 2300 Tupper Street in 1956, and it was renamed the Montreal Children's Hospital.

In August 1997, the Montreal Children's Hospital merged with the Royal Victoria Hospital, the Montreal General Hospital, the Montreal Neurological Institute and Hospital and the Montreal Chest Institute to form the McGill University Health Centre.

The location of the Montreal Children's Hospital at 2300 Tupper Street officially closed at 11:00 on May 24, 2015, after 68 patients were transferred to the new Glen Site at 1001 Décarie Boulevard.
The new Glen Site Montreal Children's Hospital opened its emergency doors at 5 AM.
The Glen Site is composed of different hospital centres.
The Montreal Children's Hospital (MCH) first opened on the rented premise of 500 Guy Street on January 30, 1904. It was the first hospital in Montreal with the sole mandate of providing care for sick children. In 1909, the growing number of patients required a move to new premises on Cedar Avenue, designed by David Robertson Brown (1869–1946). In 1920, the hospital became a teaching hospital affiliated with McGill University.
The hospital has achieved a number of "firsts", including the first speech clinic in a pediatric hospital in 1933, the first division of medical genetics in 1949 and the first department of psychiatry in 1950. The increasing number of services required another expansion.  A relocation took place to 2300 Tupper Street in 1956, and it was renamed the Montreal Children's Hospital.
In August 1997, the Montreal Children's Hospital merged with the Royal Victoria Hospital, the Montreal General Hospital, the Montreal Neurological Institute and Hospital and the Montreal Chest Institute to form the McGill University Health Centre.
The location of the Montreal Children's Hospital at 2300 Tupper Street officially closed at 11:00 on May 24, 2015, after 68 patients were transferred to the new Glen Site at 1001 Décarie Boulevard. The new Glen Site Montreal Children's Hospital opened its emergency doors at 5 AM. The Glen Site is composed of different hospital centres.
Montreal Children's Hospital