Ferrucci remained in Formula 2 for 2018, competing alongside Arjun Maini at Trident.
In June, Ferrucci made his debut in IndyCar at the Detroit Grand Prix for Dale Coyne Racing as a substitute for Pietro Fittipaldi.
Ferrucci retired from his first race after colliding with Charlie Kimball on lap 56.

In July, Ferrucci was banned from four F2 races (Hungary and Belgium) after making deliberate contact with his teammate Maini after the Sprint Race at Silverstone on the weekend of the British Grand Prix.
He was also disqualified from the Sprint Race results at Silverstone for a separate incident when he deliberately forced Maini off the track, and was found to have driven his car from the support race paddock, to the race pit-lane, wearing just one glove while in possession of his cellular telephone, earning him a €60,000 fine.
Stewards at Silverstone heard testimony from the Trident team that Ferrucci, having driven into teammate Maini, was deliberate and premeditated, but not from Ferrucci himself, who did not attend, citing a family emergency requiring his immediate return to the United States following the Sprint race.

On July 18, Ferrucci was summarily fired by the Trident F2 team, citing behavioral issues, and non-payment of money required by contract.
Trident alleged that money had been made available for the Detroit IndyCar race, whilst noting that Ferrucci had defaulted on F2 debt to them.
An Italian court subsequently ordered Ferrucci to pay Trident €502,000, plus interest and legal fees, for failing to make payments.

6 days later, Trident announced that their GP3 Series driver Alessio Lorandi would be his replacement for the rest of the season.

Santino contested the final two rounds of the IndyCar Series season with Dale Coyne Racing.
Ferrucci remained in Formula 2 for 2018, competing alongside Arjun Maini at Trident. In June, Ferrucci made his debut in IndyCar at the Detroit Grand Prix for Dale Coyne Racing as a substitute for Pietro Fittipaldi. Ferrucci retired from his first race after colliding with Charlie Kimball on lap 56.
In July, Ferrucci was banned from four F2 races (Hungary and Belgium) after making deliberate contact with his teammate Maini after the Sprint Race at Silverstone on the weekend of the British Grand Prix. He was also disqualified from the Sprint Race results at Silverstone for a separate incident when he deliberately forced Maini off the track, and was found to have driven his car from the support race paddock, to the race pit-lane, wearing just one glove while in possession of his cellular telephone, earning him a €60,000 fine. Stewards at Silverstone heard testimony from the Trident team that Ferrucci, having driven into teammate Maini, was deliberate and premeditated, but not from Ferrucci himself, who did not attend, citing a family emergency requiring his immediate return to the United States following the Sprint race.
On July 18, Ferrucci was summarily fired by the Trident F2 team, citing behavioral issues, and non-payment of money required by contract. Trident alleged that money had been made available for the Detroit IndyCar race, whilst noting that Ferrucci had defaulted on F2 debt to them. An Italian court subsequently ordered Ferrucci to pay Trident €502,000, plus interest and legal fees, for failing to make payments.
6 days later, Trident announced that their GP3 Series driver Alessio Lorandi would be his replacement for the rest of the season.
Santino contested the final two rounds of the IndyCar Series season with Dale Coyne Racing.
Santino Ferrucci