After three years as one of baseball's most dominating closers, the team's management agreed to return Smoltz to the starting rotation before the 2005 season.
His renewed career as a starter began inauspiciously.
He allowed six earned runs in only 1​²⁄₃ innings—matching the shortest starts of his career—as the Braves were blown out on Opening Day by the Marlins.
Poor run support contributed to an 0–3 start despite stronger pitching performances by Smoltz.
After these initial difficulties, though, things fell into place.
At the All-Star break, Smoltz was 9–5 with an ERA of 2.68 and was chosen for the 2005 NL All-Star team.
Smoltz gave up a solo home run to Miguel Tejada in the second inning of the American League's 7–5 victory and was charged with the loss.
For his career, he was 1–2 in All-Star games, putting him in a tie for the most losses.

Smoltz finished 2005 at 14–7, with a 3.06 ERA and 169 strikeouts while allowing less than one hit per inning.
Smoltz had answered the critics who doubted he would be able to reach the 200-inning plateau after three years in the bullpen.
Nonetheless, Smoltz's increased workload caused him to wear down toward the end of the season.

Despite a sore shoulder, Smoltz pitched seven innings in the Braves' 7–1 win over the Houston Astros in Game 2 of the 2005 NL Division Series; it was the only game the Braves won in the series against the eventual National League champions.
The victory over Houston gave Smoltz a 13–4 record as a starter (15–4 overall) with a 2.65 ERA in the postseason.
In two of those post-season losses, he surrendered only unearned runs.
He has the second most postseason wins (15) behind only Andy Pettitte with 19.
They are followed by Glavine (14) and Maddux (11).

In 2006, Smoltz finished the season with a record of 16–9, an ERA of 3.49, and 211 strikeouts.
He was one of four pitchers tied for the NL lead in wins, and was third in strikeouts.
He pitched more than well enough for a 20-win season, but the Braves' bullpen blew six of his leads, on their way to being the single-handed cause of the end of the team's playoff appearance streak.
The number of blown saves alone by the Braves' bullpen was greater than the number of games out of first place the team finished.
 
On September 21, 2006, the Braves announced they had picked up Smoltz's $8 million contract option for the 2007 season.
On April 26, 2007, Smoltz agreed to a contract extension with the Braves.
The extension includes a $14 million salary for the 2008 season, a $12 million vesting option for 2009 dependent on his ability to pitch 200 innings in 2008 and a $12 or $13 million team option for 2010 dependent on his ability to pitch 200 innings in 2009.

2007 was a year of reunions and milestones for Smoltz.
On May 9, he faced Maddux for the first time since July 10, 1992.
Smoltz earned a win in a 3–2 victory over the San Diego Padres; Maddux received no decision.
On May 24, exactly 11 years to the day after recording his 100th win, Smoltz recorded his 200th win against Glavine.
He faced Glavine three other times, faring 3–1 overall against him.
On June 27, Smoltz, Glavine and Maddux each recorded wins on the same day.
On August 19, Smoltz set the Braves strikeout record by striking out the Arizona Diamondbacks' Mark Reynolds.
It was his 2,913th strikeout, passing Phil Niekro on the club' all-time list; he struck out a season-high 12 in the game.
He finished the year 14–8 with a 3.11 ERA and 197 strikeouts.
The stalwart pitcher was the only holdover on the Braves roster from their 1991 worst-to-first season until Glavine returned to the Braves after an absence of several years following the 2007 season.

On April 22, 2008, Smoltz became the 16th pitcher in major-league history to reach 3,000 career strikeouts, and the fourth pitcher to strike out 3,000 batters for one team, joining Walter Johnson, Bob Gibson and Steve Carlton.

On April 28, 2008, Smoltz was placed on the 15-day disabled list due to an inflamed right shoulder.
After three years as one of baseball's most dominating closers, the team's management agreed to return Smoltz to the starting rotation before the 2005 season. His renewed career as a starter began inauspiciously. He allowed six earned runs in only 1​²⁄₃ innings—matching the shortest starts of his career—as the Braves were blown out on Opening Day by the Marlins. Poor run support contributed to an 0–3 start despite stronger pitching performances by Smoltz. After these initial difficulties, though, things fell into place. At the All-Star break, Smoltz was 9–5 with an ERA of 2.68 and was chosen for the 2005 NL All-Star team. Smoltz gave up a solo home run to Miguel Tejada in the second inning of the American League's 7–5 victory and was charged with the loss. For his career, he was 1–2 in All-Star games, putting him in a tie for the most losses.
Smoltz finished 2005 at 14–7, with a 3.06 ERA and 169 strikeouts while allowing less than one hit per inning. Smoltz had answered the critics who doubted he would be able to reach the 200-inning plateau after three years in the bullpen. Nonetheless, Smoltz's increased workload caused him to wear down toward the end of the season.
Despite a sore shoulder, Smoltz pitched seven innings in the Braves' 7–1 win over the Houston Astros in Game 2 of the 2005 NL Division Series; it was the only game the Braves won in the series against the eventual National League champions. The victory over Houston gave Smoltz a 13–4 record as a starter (15–4 overall) with a 2.65 ERA in the postseason. In two of those post-season losses, he surrendered only unearned runs. He has the second most postseason wins (15) behind only Andy Pettitte with 19. They are followed by Glavine (14) and Maddux (11).
In 2006, Smoltz finished the season with a record of 16–9, an ERA of 3.49, and 211 strikeouts. He was one of four pitchers tied for the NL lead in wins, and was third in strikeouts. He pitched more than well enough for a 20-win season, but the Braves' bullpen blew six of his leads, on their way to being the single-handed cause of the end of the team's playoff appearance streak. The number of blown saves alone by the Braves' bullpen was greater than the number of games out of first place the team finished.  
On September 21, 2006, the Braves announced they had picked up Smoltz's $8 million contract option for the 2007 season. On April 26, 2007, Smoltz agreed to a contract extension with the Braves. The extension includes a $14 million salary for the 2008 season, a $12 million vesting option for 2009 dependent on his ability to pitch 200 innings in 2008 and a $12 or $13 million team option for 2010 dependent on his ability to pitch 200 innings in 2009.
2007 was a year of reunions and milestones for Smoltz. On May 9, he faced Maddux for the first time since July 10, 1992. Smoltz earned a win in a 3–2 victory over the San Diego Padres; Maddux received no decision. On May 24, exactly 11 years to the day after recording his 100th win, Smoltz recorded his 200th win against Glavine. He faced Glavine three other times, faring 3–1 overall against him. On June 27, Smoltz, Glavine and Maddux each recorded wins on the same day. On August 19, Smoltz set the Braves strikeout record by striking out the Arizona Diamondbacks' Mark Reynolds. It was his 2,913th strikeout, passing Phil Niekro on the club' all-time list; he struck out a season-high 12 in the game. He finished the year 14–8 with a 3.11 ERA and 197 strikeouts. The stalwart pitcher was the only holdover on the Braves roster from their 1991 worst-to-first season until Glavine returned to the Braves after an absence of several years following the 2007 season.
On April 22, 2008, Smoltz became the 16th pitcher in major-league history to reach 3,000 career strikeouts, and the fourth pitcher to strike out 3,000 batters for one team, joining Walter Johnson, Bob Gibson and Steve Carlton.
On April 28, 2008, Smoltz was placed on the 15-day disabled list due to an inflamed right shoulder.
John Smoltz