The town was conquered by the Spanish between 1530 and 1540.
On July 26, 1569 the Guatemalan Bishop Bernardino Villalpando Sihuatehuacán renamed the Santa Ana, La Grande.
In the year 1532 was given to Diego de Usagre and from 1540-1786 served on the Mayor of San Salvador .
In 1550 he was entrusted to Antonio Docampo.

San Salvador, the city of Santa Ana, and the western and central part of the current Salvadoran territory (except St. Vincent and the paracentral area) was administered by the mayor of the department of San Salvador.
Since 1770 the central parish of the city (located where the cathedral was built later) was the head of the parish of Santa Ana.
From the year 1786-1824 was the capitol of the Santa Ana district, which was part of the Municipality San Salvador (Intendencia de San Salvador).
The town was conquered by the Spanish between 1530 and 1540. On July 26, 1569 the Guatemalan Bishop Bernardino Villalpando Sihuatehuacán renamed the Santa Ana, La Grande. In the year 1532 was given to Diego de Usagre and from 1540-1786 served on the Mayor of San Salvador . In 1550 he was entrusted to Antonio Docampo. 
San Salvador, the city of Santa Ana, and the western and central part of the current Salvadoran territory (except St. Vincent and the paracentral area) was administered by the mayor of the department of San Salvador. Since 1770 the central parish of the city (located where the cathedral was built later) was the head of the parish of Santa Ana. From the year 1786-1824 was the capitol of the Santa Ana district, which was part of the Municipality San Salvador (Intendencia de San Salvador).
Santa Ana, El Salvador