In 1912, the B&O remodeled the central waiting room, enlarging it and adding oak panelling with marble wainscoting for the Democratic National Convention, held in Baltimore that year.
The Annapolis & Baltimore Short Line Railroad also used Camden Station for its trains to Annapolis, Maryland, beginning in 1887.
Except for an interval between 1921–1935, when the successor Washington, Baltimore and Annapolis Electric Railway (WB&A) used a separate station at Howard and Lombard Streets, frequent electric interurban trains to Maryland's capitol served Camden station until February 5, 1950, when WB&A successor Baltimore and Annapolis Railroad replaced rail passenger service with buses.

The first streamlined, non-articulated diesel locomotive in the U.S., EMC EA-EB #51, began using Camden Station's lower level platforms in 1937, pulling the B&O's famed Royal Blue.
In addition to its New York–Washington service and frequent commuter trains to Washington, the B&O also operated extensive long-distance service at Camden Station to such cities as Chicago, Detroit, Cleveland, and St. Louis.
The Capitol Limited, Shenandoah, and Washington–Chicago Express to Chicago and the National Limited, Diplomat, and Metropolitan Special to St. Louis were among the many trains arriving and departing daily from the station during the first half of the 20th century.
When the modern-era Major League Baseball Baltimore Orioles began playing in Baltimore, they arrived at Camden by B&O train from Detroit for their inaugural home opening game of the 1954 season.

Declining rail passenger traffic in the 1950s and 1960s led to substantial reductions in passenger train arrivals and departures at the venerable station.
On April 26, 1958, the B&O discontinued all passenger service to Philadelphia and New York, and Camden Station's lower level platforms were used thereafter only for a few trains that continued to Mount Royal Station.
When Mount Royal closed in 1961, the lower level platforms were removed.
Today, the lower level tracks and the Howard Street tunnel continue to be extensively used by freight trains of B&O's successor CSX Transportation, as part of its mainline system.
The inception of Amtrak on May 1, 1971  marked the demise of all B&O long-haul passenger service.
Thereafter, only B&O's local commuter trains, mostly Budd Rail Diesel Cars, continued to use Camden Station.
Baltimore Sun commentator Jacques Kelly described Camden Station in its twilight years of B&O operation in the 1980s: "Spotlessly maintained, it radiated the goodwill and a non-arrogant style typical of B&O employees  ... its golden oak benches and large overhead lamps were maintained in the same pristine condition as when they welcomed delegates to the 1912 Democratic Presidential Convention."
In 1912, the B&O remodeled the central waiting room, enlarging it and adding oak panelling with marble wainscoting for the Democratic National Convention, held in Baltimore that year. The Annapolis & Baltimore Short Line Railroad also used Camden Station for its trains to Annapolis, Maryland, beginning in 1887. Except for an interval between 1921–1935, when the successor Washington, Baltimore and Annapolis Electric Railway (WB&A) used a separate station at Howard and Lombard Streets, frequent electric interurban trains to Maryland's capitol served Camden station until February 5, 1950, when WB&A successor Baltimore and Annapolis Railroad replaced rail passenger service with buses.
The first streamlined, non-articulated diesel locomotive in the U.S., EMC EA-EB #51, began using Camden Station's lower level platforms in 1937, pulling the B&O's famed Royal Blue. In addition to its New York–Washington service and frequent commuter trains to Washington, the B&O also operated extensive long-distance service at Camden Station to such cities as Chicago, Detroit, Cleveland, and St. Louis. The Capitol Limited, Shenandoah, and Washington–Chicago Express to Chicago and the National Limited, Diplomat, and Metropolitan Special to St. Louis were among the many trains arriving and departing daily from the station during the first half of the 20th century. When the modern-era Major League Baseball Baltimore Orioles began playing in Baltimore, they arrived at Camden by B&O train from Detroit for their inaugural home opening game of the 1954 season.
Declining rail passenger traffic in the 1950s and 1960s led to substantial reductions in passenger train arrivals and departures at the venerable station. On April 26, 1958, the B&O discontinued all passenger service to Philadelphia and New York, and Camden Station's lower level platforms were used thereafter only for a few trains that continued to Mount Royal Station. When Mount Royal closed in 1961, the lower level platforms were removed. Today, the lower level tracks and the Howard Street tunnel continue to be extensively used by freight trains of B&O's successor CSX Transportation, as part of its mainline system. The inception of Amtrak on May 1, 1971  marked the demise of all B&O long-haul passenger service. Thereafter, only B&O's local commuter trains, mostly Budd Rail Diesel Cars, continued to use Camden Station. Baltimore Sun commentator Jacques Kelly described Camden Station in its twilight years of B&O operation in the 1980s: "Spotlessly maintained, it radiated the goodwill and a non-arrogant style typical of B&O employees  ... its golden oak benches and large overhead lamps were maintained in the same pristine condition as when they welcomed delegates to the 1912 Democratic Presidential Convention."
Camden Station