The Massachusetts Bay Colony passed numerous legislation against Indian culture and religion.
 New laws were passed to limit the influence of the powwows, or 'shamans', and restricted the ability of non-converted Native Americans to enter English towns on Sabbath.
 The Nipmuc were also informed that any unimproved lands were fair game for incorporation into the growing colony.
 These draconian measures and the increasing amount of land lost to the settlers led many Nipmuc to join the Wampanoag chief Metacomet in a rebellion against the English which would ravage New England from 1675–1676.
 The Native Americans that had already settled the Praying towns were interned on Deer Island in Boston Harbor over the winter where a great many perished from starvation and exposure to the elements.
 Although many of the Native Americans fled to join the uprising, other Native Americans joined the English.
 The Praying Indians were particularly at risk, as the war made all Native Americans suspect, but the Praying towns were also attacked by the 'wild' Native Americans that joined the rebellion.
 The Nipmuc were major participants in the siege of Lancaster, Brookfield, Sudbury and Bloody Brook, all in Massachusetts, and the tribe prepared thoroughly for conflict by forming alliances, and the group even had "an experienced gunsmith, a lame man, who kept their weapons in good working order."
 The siege of Lancaster also lead to the capture of Mary Rowlandson, who was placed in captivity until ransomed for £20 and would later write a memoir of her captivity.
 The Native Americans lost the war, and survivors were hunted down, murdered, sold into slavery in the West Indies or forced to leave the area.
The Massachusetts Bay Colony passed numerous legislation against Indian culture and religion.  New laws were passed to limit the influence of the powwows, or 'shamans', and restricted the ability of non-converted Native Americans to enter English towns on Sabbath.  The Nipmuc were also informed that any unimproved lands were fair game for incorporation into the growing colony.  These draconian measures and the increasing amount of land lost to the settlers led many Nipmuc to join the Wampanoag chief Metacomet in a rebellion against the English which would ravage New England from 1675–1676.  The Native Americans that had already settled the Praying towns were interned on Deer Island in Boston Harbor over the winter where a great many perished from starvation and exposure to the elements.  Although many of the Native Americans fled to join the uprising, other Native Americans joined the English.  The Praying Indians were particularly at risk, as the war made all Native Americans suspect, but the Praying towns were also attacked by the 'wild' Native Americans that joined the rebellion.  The Nipmuc were major participants in the siege of Lancaster, Brookfield, Sudbury and Bloody Brook, all in Massachusetts, and the tribe prepared thoroughly for conflict by forming alliances, and the group even had "an experienced gunsmith, a lame man, who kept their weapons in good working order."  The siege of Lancaster also lead to the capture of Mary Rowlandson, who was placed in captivity until ransomed for £20 and would later write a memoir of her captivity.  The Native Americans lost the war, and survivors were hunted down, murdered, sold into slavery in the West Indies or forced to leave the area.
Nipmuc