In the colonial era and in the early United States, the valley of the river provided an important route of access through the mountains for settlers and military forces from Virginia to western Pennsylvania and the Ohio Country.
In 1754, as a militia officer of the British Colony of Virginia, George Washington followed the river in an attempt to find a water route to Fort Duquesne, then held by the French.

During the uncommonly severe winter of 1787-88, American pioneers to the Northwest Territory departed New England and cut trails westward through the mountains.
At Sumrill's Ferry, present-day West Newton, Pennsylvania, on the Youghiogheny River, the men built flatboats which carried them down the Youghiogheny River to the Monongahela River, and then to the Ohio River, and onward to the Northwest Territory.

The pioneer town of Somerfield, Pennsylvania, was inundated by the building of the Youghiogheny Dam.
Perryopolis in northern Fayette County, Pennsylvania, is the site of the George Washington Grist Mill.
The Youghiogheny River Trail follows the river in southwestern Pennsylvania southeast of Connellsville.

Coal mining became an important industry along the lower Youghiogheny River during the 19th century.
 At that time, the name was often spelled Yohoghany (or variants thereof), and during the 1860s and 1870s that spelling was used as the name of a post office near what is now Shaner in Westmoreland County.

Fallingwater, designed by Frank Lloyd Wright, is located in the river valley southeast of Connellsville.

In 1976, a 21-mile long segment of the Youghiogheny in Maryland was given special protected status by the state as the Youghiogheny Scenic & Wild River.
Though most of the land along this corridor is private, it is managed by the Maryland Department of Natural Resources to preserve its natural and cultural resources.
In the colonial era and in the early United States, the valley of the river provided an important route of access through the mountains for settlers and military forces from Virginia to western Pennsylvania and the Ohio Country. In 1754, as a militia officer of the British Colony of Virginia, George Washington followed the river in an attempt to find a water route to Fort Duquesne, then held by the French.
During the uncommonly severe winter of 1787-88, American pioneers to the Northwest Territory departed New England and cut trails westward through the mountains. At Sumrill's Ferry, present-day West Newton, Pennsylvania, on the Youghiogheny River, the men built flatboats which carried them down the Youghiogheny River to the Monongahela River, and then to the Ohio River, and onward to the Northwest Territory.
The pioneer town of Somerfield, Pennsylvania, was inundated by the building of the Youghiogheny Dam. Perryopolis in northern Fayette County, Pennsylvania, is the site of the George Washington Grist Mill. The Youghiogheny River Trail follows the river in southwestern Pennsylvania southeast of Connellsville.
Coal mining became an important industry along the lower Youghiogheny River during the 19th century.  At that time, the name was often spelled Yohoghany (or variants thereof), and during the 1860s and 1870s that spelling was used as the name of a post office near what is now Shaner in Westmoreland County.
Fallingwater, designed by Frank Lloyd Wright, is located in the river valley southeast of Connellsville.
In 1976, a 21-mile long segment of the Youghiogheny in Maryland was given special protected status by the state as the Youghiogheny Scenic & Wild River. Though most of the land along this corridor is private, it is managed by the Maryland Department of Natural Resources to preserve its natural and cultural resources.
Youghiogheny River