South Run begins in a broad valley near Hickory Knob in Monroe Township.
It flows in a northerly direction for several tenths of a mile before turning northwest as its valley narrows.
After several tenths of a mile, the stream turns north for several tenths of a mile before turning northwest and then north again.
It then reaches its confluence with Bowman Creek.

South Run joins Bowman Creek 11.68 miles (18.80 km) upstream of its mouth.
South Run begins in a broad valley near Hickory Knob in Monroe Township. It flows in a northerly direction for several tenths of a mile before turning northwest as its valley narrows. After several tenths of a mile, the stream turns north for several tenths of a mile before turning northwest and then north again. It then reaches its confluence with Bowman Creek.
South Run joins Bowman Creek 11.68 miles (18.80 km) upstream of its mouth.
South Run (Bowman Creek tributary)