During the 2006 offseason, Loretta was traded to the Boston Red Sox in exchange for catcher Doug Mirabelli.

In 2006, Loretta hit .285 with five home runs and 59 RBI in 155 games with the Red Sox.
Loretta was awarded a start at second base for the American League in the 2006 MLB All-Star Game.
Due to various injuries to teammates, Loretta also filled in at first base and as the designated hitter at various points during the season.
He hit his first career walk-off home run on April 17, 2006, against the Seattle Mariners on Patriots' Day at Fenway Park.
This was also his first home run of the season.
During the 2006 offseason, Loretta was traded to the Boston Red Sox in exchange for catcher Doug Mirabelli.
In 2006, Loretta hit .285 with five home runs and 59 RBI in 155 games with the Red Sox. Loretta was awarded a start at second base for the American League in the 2006 MLB All-Star Game. Due to various injuries to teammates, Loretta also filled in at first base and as the designated hitter at various points during the season. He hit his first career walk-off home run on April 17, 2006, against the Seattle Mariners on Patriots' Day at Fenway Park. This was also his first home run of the season.
Mark Loretta