After moving to the Mississippi Territory in 1802, Poindexter set up his law practice in Natchez.
 He soon became a friend of Governor William C. C. Claiborne, and a leader in the local Democratic-Republican Party.
 As a result, in 1803, he was appointed Attorney General of the Territory; he served until 1807, when he took up his duties as a member of the Territorial House of Representatives, to which he had been elected in 1806.
 (He had been an unsuccessful candidate for the legislature in 1804.)

During Mississippi's early years, nearby areas were under Spanish control.
 When tensions rose over Mississippi's expansion, and the Spanish threatened an attack, residents of Adams County formed a militia; Poindexter was one of the main organizers of a company in Natchez, the Mississippi Blues, and he was elected commander with the rank of captain.
 No attack from Spain materialized, and the militia soon disbanded.

When former U.S. Vice President Aaron Burr appeared in Mississippi while traveling south as part of the Burr conspiracy in 1807, acting Governor Cowles Mead declared martial law, and appointed Poindexter and William B. Shields as aides-de-camp on his military staff, and sent them to interview Burr and determine his intentions.
 When Burr was arrested, Poindexter conducted the prosecution until Burr's escape from custody.
 After Burr escaped, Governor Robert Williams returned from vacation at his home in North Carolina to personally take control of the situation; he criticized Mead and fired the militia officers Mead had appointed, including Poindexter.
After moving to the Mississippi Territory in 1802, Poindexter set up his law practice in Natchez.  He soon became a friend of Governor William C. C. Claiborne, and a leader in the local Democratic-Republican Party.  As a result, in 1803, he was appointed Attorney General of the Territory; he served until 1807, when he took up his duties as a member of the Territorial House of Representatives, to which he had been elected in 1806.  (He had been an unsuccessful candidate for the legislature in 1804.)
During Mississippi's early years, nearby areas were under Spanish control.  When tensions rose over Mississippi's expansion, and the Spanish threatened an attack, residents of Adams County formed a militia; Poindexter was one of the main organizers of a company in Natchez, the Mississippi Blues, and he was elected commander with the rank of captain.  No attack from Spain materialized, and the militia soon disbanded.
When former U.S. Vice President Aaron Burr appeared in Mississippi while traveling south as part of the Burr conspiracy in 1807, acting Governor Cowles Mead declared martial law, and appointed Poindexter and William B. Shields as aides-de-camp on his military staff, and sent them to interview Burr and determine his intentions.  When Burr was arrested, Poindexter conducted the prosecution until Burr's escape from custody.  After Burr escaped, Governor Robert Williams returned from vacation at his home in North Carolina to personally take control of the situation; he criticized Mead and fired the militia officers Mead had appointed, including Poindexter.
George Poindexter