In 1836 the Hudson's Bay Company established a trading post at North West River and the traders provided the Innu with European tools.

During the First World War, some Innu from Sheshatshiu fought overseas in the Royal Newfoundland Regiment.
In 1915 the International Grenfell Association established a hospital in North West River to serve the European settlers and indigenous people of the region.
This hospital was closed in 1983 and residents of Sheshatshiu and North West River now rely on Happy Valley-Goose Bay for medical services.

In 1946 elections were held to send delegates to the Newfoundland National Convention.
This was the first time an election was held in Labrador.
Lester Burry was elected to the convention and he supported future premier Joey Smallwood and his proposal of confederation with Canada.

In 1949 when Newfoundland and Labrador joined Canada the Indian Act did not include the First Nations of the province.
This was done to preserve their right to vote however it also prevented the Innu from protecting their land and culture.

The Innu of Labrador settled into permanent villages in the 1960s and were one of the last Aboriginal groups in Canada to do so.
Previously, Sheshatshiu had only been used by the Innu as a coastal settlement and for trading with Europeans.

In November 2000, the community, along with Davis Inlet, took the unprecedented step of asking the Canadian federal government to step in and assist with a local addiction crisis.
Due to a variety of factors, including economic adversity, alcoholism and gas sniffing were both rampant in the community, in some cases affecting children as young as five years old.

Labrador's Innu became status Indians under the Indian Act in 2002 and "Sheshatshiu 3" became a reserve in 2006.

In 2017, the Innu Nation stated that there are 165 Labrador Innu children in foster care, 80 of whom are placed outside their home communities of Sheshatshiu and Natuashish.

In October 2019, the Sheshatshiu Innu First Nation declared a suicide crisis after 10 suicide attempts were reported within the community in a matter of days.

As of 2020, according to Innu Nation Grand Chief Gregory Rich, Sheshatshiu and Natuashish have a collective population of about 3,000 with about half of that being youths.
Of that 167 of them are in the care of the Manager of Child and Youth Services.
In 1836 the Hudson's Bay Company established a trading post at North West River and the traders provided the Innu with European tools.
During the First World War, some Innu from Sheshatshiu fought overseas in the Royal Newfoundland Regiment. In 1915 the International Grenfell Association established a hospital in North West River to serve the European settlers and indigenous people of the region. This hospital was closed in 1983 and residents of Sheshatshiu and North West River now rely on Happy Valley-Goose Bay for medical services.
In 1946 elections were held to send delegates to the Newfoundland National Convention. This was the first time an election was held in Labrador. Lester Burry was elected to the convention and he supported future premier Joey Smallwood and his proposal of confederation with Canada.
In 1949 when Newfoundland and Labrador joined Canada the Indian Act did not include the First Nations of the province. This was done to preserve their right to vote however it also prevented the Innu from protecting their land and culture.
The Innu of Labrador settled into permanent villages in the 1960s and were one of the last Aboriginal groups in Canada to do so. Previously, Sheshatshiu had only been used by the Innu as a coastal settlement and for trading with Europeans.
In November 2000, the community, along with Davis Inlet, took the unprecedented step of asking the Canadian federal government to step in and assist with a local addiction crisis. Due to a variety of factors, including economic adversity, alcoholism and gas sniffing were both rampant in the community, in some cases affecting children as young as five years old.
Labrador's Innu became status Indians under the Indian Act in 2002 and "Sheshatshiu 3" became a reserve in 2006.
In 2017, the Innu Nation stated that there are 165 Labrador Innu children in foster care, 80 of whom are placed outside their home communities of Sheshatshiu and Natuashish.
In October 2019, the Sheshatshiu Innu First Nation declared a suicide crisis after 10 suicide attempts were reported within the community in a matter of days.
As of 2020, according to Innu Nation Grand Chief Gregory Rich, Sheshatshiu and Natuashish have a collective population of about 3,000 with about half of that being youths. Of that 167 of them are in the care of the Manager of Child and Youth Services.
Sheshatshiu