Lord de Tabley married Catharina Barbara 'Nina', daughter of Jerome, 4th Count de Salis-Soglio, in 1832.
They had two sons and four daughters:
John Byrne Leicester Warren, 3rd Baron de Tabley (1835–1895).

Hon.
Catharine Leicester (1838–1881).
Buried Harlington, Middlesex, beside her mother.
In 1884 the women's ward of the Harlington, Harmondsworth and Cranford Cottage Hospital was named after her.

Hon.
Meriel Warren (1839–72), married Allen Bathurst in 1862.

Hon.
Eleanor (1841-14 August 1914), married Sir Baldwyn Leighton, 8th Baronet (1836-2 January 1897), of Loton, Shropshire, in 1864.
She was (eventual) heir to her brother in 1895, and in 1900 took the name Leighton-Warren.
Barbara Sotheby (1870–1952), photographer and painter, was her daughter.

Hon.
Francis Peter Leicester Warren (1842–1845).

Hon.
Margaret Warren (1847–1921), married Arthur Cowell-Stepney, 2nd Baronet (aka Emile Algernon Arthur Keppel Cowell-Stepney) (1834–1909), of Llanelli, in 1875.
Their daughter Catherine Muriel Cowell-Stepney (Miss Alcyone Stepney) (1876–1952), was painted by Sir John Everett Millais.
She married Sir Stafford Howard in 1911.

Lady de Tabley died in 1869.
Her husband survived her by eighteen years and died in October 1887, aged 75, to be succeeded in his titles by his eldest and only surviving son, John.
Lord de Tabley married Catharina Barbara 'Nina', daughter of Jerome, 4th Count de Salis-Soglio, in 1832. They had two sons and four daughters:
John Byrne Leicester Warren, 3rd Baron de Tabley (1835–1895).
Hon. Catharine Leicester (1838–1881). Buried Harlington, Middlesex, beside her mother. In 1884 the women's ward of the Harlington, Harmondsworth and Cranford Cottage Hospital was named after her.
Hon. Meriel Warren (1839–72), married Allen Bathurst in 1862.
Hon. Eleanor (1841-14 August 1914), married Sir Baldwyn Leighton, 8th Baronet (1836-2 January 1897), of Loton, Shropshire, in 1864. She was (eventual) heir to her brother in 1895, and in 1900 took the name Leighton-Warren. Barbara Sotheby (1870–1952), photographer and painter, was her daughter.
Hon. Francis Peter Leicester Warren (1842–1845).
Hon. Margaret Warren (1847–1921), married Arthur Cowell-Stepney, 2nd Baronet (aka Emile Algernon Arthur Keppel Cowell-Stepney) (1834–1909), of Llanelli, in 1875. Their daughter Catherine Muriel Cowell-Stepney (Miss Alcyone Stepney) (1876–1952), was painted by Sir John Everett Millais. She married Sir Stafford Howard in 1911.
Lady de Tabley died in 1869. Her husband survived her by eighteen years and died in October 1887, aged 75, to be succeeded in his titles by his eldest and only surviving son, John.
George Warren, 2nd Baron de Tabley