On September 3, 1829, he married Abigail Brown Brooks (1808–1889), whose father was shipping magnate Peter Chardon Brooks (1767–1849).
 She had two sisters, Charlotte, who was married to Edward Everett, a Massachusetts politician, and Ann, who was married to Nathaniel Frothingham, a Unitarian minister.
 Together, they were the parents of:
Louisa Catherine Adams (1831–1870), who married Charles Kuhn
John Quincy Adams II (1833–1894)
Charles Francis Adams Jr. (1835–1915)
Henry Brooks Adams (1838–1918)
Arthur George Adams (1841–1846), who died young
Mary Gardiner Adams (1845–1928), who married Dr. Henry Parker Quincy
Peter Chardon Brooks Adams (1848–1927)
Adams died in Boston on November 21, 1886, and was interred in Mount Wollaston Cemetery, Quincy.
He was the last surviving child of John Quincy Adams.

His wife Abigail's "health and spirits" worsened after her husband's death, and she died at Peacefield on June 6, 1889.
On September 3, 1829, he married Abigail Brown Brooks (1808–1889), whose father was shipping magnate Peter Chardon Brooks (1767–1849).  She had two sisters, Charlotte, who was married to Edward Everett, a Massachusetts politician, and Ann, who was married to Nathaniel Frothingham, a Unitarian minister.  Together, they were the parents of:
Louisa Catherine Adams (1831–1870), who married Charles Kuhn
John Quincy Adams II (1833–1894)
Charles Francis Adams Jr. (1835–1915)
Henry Brooks Adams (1838–1918)
Arthur George Adams (1841–1846), who died young
Mary Gardiner Adams (1845–1928), who married Dr. Henry Parker Quincy
Peter Chardon Brooks Adams (1848–1927)
Adams died in Boston on November 21, 1886, and was interred in Mount Wollaston Cemetery, Quincy. He was the last surviving child of John Quincy Adams.
His wife Abigail's "health and spirits" worsened after her husband's death, and she died at Peacefield on June 6, 1889.
Charles Francis Adams Sr.