Ranuccio II was married three times:
On 29 April 1660, Ranuccio married firstly Marguerite Yolande of Savoy (b. 15 November 1635 – d. 29 April 1663), a daughter of Victor Amadeus I, Duke of Savoy and Christine Marie of France.
They had two children:
On 18 February 1664 Ranuccio married secondly Isabella d'Este of Modena (b. 3 October 1635 – d. 17 August 1666), a daughter of Francesco I d'Este and his cousin.
They had three children:
On 1 January 1668 he married Maria d'Este of Modena, (b. 8 December 1644 – d. 20 August 1684), his second wife's sister.
They had nine children:
Ranuccio II was married three times:
On 29 April 1660, Ranuccio married firstly Marguerite Yolande of Savoy (b. 15 November 1635 – d. 29 April 1663), a daughter of Victor Amadeus I, Duke of Savoy and Christine Marie of France. They had two children:
On 18 February 1664 Ranuccio married secondly Isabella d'Este of Modena (b. 3 October 1635 – d. 17 August 1666), a daughter of Francesco I d'Este and his cousin. They had three children:
On 1 January 1668 he married Maria d'Este of Modena, (b. 8 December 1644 – d. 20 August 1684), his second wife's sister. They had nine children:
Ranuccio II Farnese, Duke of Parma