Over the next years, de Mesquita principally devoted himself to art, experimenting with various techniques and mediums.
Though known primarily for his wood engravings, he also produced etchings, lithographs, watercolors and drawings; his applied art consisted mostly of material designs.
There are birds, exotic animals, plants and flowers, and fantastical representations, both humorous and grim.
Among de Mesquita's most beautiful works are his portraits, particularly his self-portraits.

With Nazi Germany's invasion of the Netherlands in May 1940, de Mesquita, already in poor health, was forced to lead a secluded life, limiting his work largely to sketches.
Over the next years, de Mesquita principally devoted himself to art, experimenting with various techniques and mediums. Though known primarily for his wood engravings, he also produced etchings, lithographs, watercolors and drawings; his applied art consisted mostly of material designs. There are birds, exotic animals, plants and flowers, and fantastical representations, both humorous and grim. Among de Mesquita's most beautiful works are his portraits, particularly his self-portraits.
With Nazi Germany's invasion of the Netherlands in May 1940, de Mesquita, already in poor health, was forced to lead a secluded life, limiting his work largely to sketches.
Samuel Jessurun de Mesquita