Holbein was born in the free imperial city of Augsburg during the winter of 1497–98.
He was a son of the painter and draughtsman Hans Holbein the Elder, whose trade he and his older brother, Ambrosius, followed.
Holbein the Elder ran a large and busy workshop in Augsburg, sometimes assisted by his brother Sigmund, also a painter.

By 1515, Hans and Ambrosius had moved as journeymen painters to the city of Basel, a centre of learning and the printing trade.
There they were apprenticed to Hans Herbster, Basel's leading painter.
The brothers found work in Basel as designers of woodcuts and metalcuts for printers.
In 1515, the preacher and theologian Oswald Myconius invited them to add pen drawings to the margin of a copy of The Praise of Folly by the humanist scholar Desiderius Erasmus of Rotterdam.
The sketches provide early evidence of Holbein's wit and humanistic leaning.
His other early works, including the double portrait of Basel's mayor Jakob Meyer zum Hasen and his wife Dorothea, follow his father's style.

The young Holbein, alongside his brother and his father, is pictured in the left-hand panel of Holbein the Elder's 1504 altar-piece triptych the Basilica of St. Paul, which is displayed at the Staatsgalerie in Augsburg.

In 1517, father and son began a project in Lucerne (Luzern), painting internal and external murals for the merchant Jakob von Hertenstein.
While in Lucerne Holbein also designed cartoons for stained glass.
The city's records show that on 10 December 1517, he was fined five livres for fighting in the street with a goldsmith called Caspar, who was fined the same amount.
That winter, Holbein probably visited northern Italy, though no record of the trip survives.
Many scholars believe he studied the work of Italian masters of fresco, such as Andrea Mantegna, before returning to Lucerne.
He filled two series of panels at Hertenstein's house with copies of works by Mantegna, including The Triumphs of Caesar.

In 1519, Holbein moved back to Basel.
His brother fades from the record at about this time, and it is usually presumed that he died.
Holbein re-established himself rapidly in the city, running a busy workshop.
He joined the painters' guild and took out Basel citizenship.
He married Elsbeth Binsenstock-Schmid, a widow a few years older than he was, who had an infant son, Franz, and was running her late husband's tanning business.
She bore Holbein a son of his own, Philipp, in their first year of marriage.

Holbein was prolific during this period in Basel, which coincided with the arrival of Lutheranism in the city.
He undertook a number of major projects, such as external murals for The House of the Dance and internal murals for the Council Chamber of the Town Hall.
The former are known from preparatory drawings.
The Council Chamber murals survive in a few poorly preserved fragments.
Holbein also produced a series of religious paintings and designed cartoons for stained glass windows.

In a period of revolution in book design, he illustrated for the publisher Johann Froben.
His woodcut designs included those for the Dance of Death, the Icones (illustrations of the Old Testament), and the title page of Martin Luther's bible.
Through the woodcut medium, Holbein refined his grasp of expressive and spatial effects.

Holbein also painted the occasional portrait in Basel, among them the double portrait of Jakob and Dorothea Meyer, and, in 1519, that of the young academic Boniface Amerbach.
According to art historian Paul Ganz, the portrait of Amerbach marks an advance in his style, notably in the use of unbroken colours.
For Meyer, he painted an altarpiece of the Madonna which included portraits of the donor, his wife, and his daughter.
In 1523, Holbein painted his first portraits of the great Renaissance scholar Erasmus, who required likenesses to send to his friends and admirers throughout Europe.
These paintings made Holbein an international artist.
Holbein visited France in 1524, probably to seek work at the court of Francis I. When Holbein decided to seek employment in England in 1526, Erasmus recommended
Holbein was born in the free imperial city of Augsburg during the winter of 1497–98. He was a son of the painter and draughtsman Hans Holbein the Elder, whose trade he and his older brother, Ambrosius, followed. Holbein the Elder ran a large and busy workshop in Augsburg, sometimes assisted by his brother Sigmund, also a painter.
By 1515, Hans and Ambrosius had moved as journeymen painters to the city of Basel, a centre of learning and the printing trade. There they were apprenticed to Hans Herbster, Basel's leading painter. The brothers found work in Basel as designers of woodcuts and metalcuts for printers. In 1515, the preacher and theologian Oswald Myconius invited them to add pen drawings to the margin of a copy of The Praise of Folly by the humanist scholar Desiderius Erasmus of Rotterdam. The sketches provide early evidence of Holbein's wit and humanistic leaning. His other early works, including the double portrait of Basel's mayor Jakob Meyer zum Hasen and his wife Dorothea, follow his father's style.
The young Holbein, alongside his brother and his father, is pictured in the left-hand panel of Holbein the Elder's 1504 altar-piece triptych the Basilica of St. Paul, which is displayed at the Staatsgalerie in Augsburg.
In 1517, father and son began a project in Lucerne (Luzern), painting internal and external murals for the merchant Jakob von Hertenstein. While in Lucerne Holbein also designed cartoons for stained glass. The city's records show that on 10 December 1517, he was fined five livres for fighting in the street with a goldsmith called Caspar, who was fined the same amount. That winter, Holbein probably visited northern Italy, though no record of the trip survives. Many scholars believe he studied the work of Italian masters of fresco, such as Andrea Mantegna, before returning to Lucerne. He filled two series of panels at Hertenstein's house with copies of works by Mantegna, including The Triumphs of Caesar.
In 1519, Holbein moved back to Basel. His brother fades from the record at about this time, and it is usually presumed that he died. Holbein re-established himself rapidly in the city, running a busy workshop. He joined the painters' guild and took out Basel citizenship. He married Elsbeth Binsenstock-Schmid, a widow a few years older than he was, who had an infant son, Franz, and was running her late husband's tanning business. She bore Holbein a son of his own, Philipp, in their first year of marriage.
Holbein was prolific during this period in Basel, which coincided with the arrival of Lutheranism in the city. He undertook a number of major projects, such as external murals for The House of the Dance and internal murals for the Council Chamber of the Town Hall. The former are known from preparatory drawings. The Council Chamber murals survive in a few poorly preserved fragments. Holbein also produced a series of religious paintings and designed cartoons for stained glass windows.
In a period of revolution in book design, he illustrated for the publisher Johann Froben. His woodcut designs included those for the Dance of Death, the Icones (illustrations of the Old Testament), and the title page of Martin Luther's bible. Through the woodcut medium, Holbein refined his grasp of expressive and spatial effects.
Holbein also painted the occasional portrait in Basel, among them the double portrait of Jakob and Dorothea Meyer, and, in 1519, that of the young academic Boniface Amerbach. According to art historian Paul Ganz, the portrait of Amerbach marks an advance in his style, notably in the use of unbroken colours. For Meyer, he painted an altarpiece of the Madonna which included portraits of the donor, his wife, and his daughter. In 1523, Holbein painted his first portraits of the great Renaissance scholar Erasmus, who required likenesses to send to his friends and admirers throughout Europe. These paintings made Holbein an international artist. Holbein visited France in 1524, probably to seek work at the court of Francis I. When Holbein decided to seek employment in England in 1526, Erasmus recommended 
Hans Holbein the Younger