Departing Sasebo, Japan, on 5 December 1945, Macomb steamed for Norfolk, Va., and Atlantic Fleet duty.
In June, 1948, Charleston, South Carolina, become her home port, and until September 1949, Macomb went on patrols and took part in exercises along the eastern coasts of the United States and Canada and in the Caribbean.
By the 1950s, Macomb had her Torpedo tubes and aft main 5inch gun removed.

On 8 September 1949, Macomb departed Charleston for the first of three brief tours of duty with the 6th Fleet in the Mediterranean.
She returned to Charleston on 13 October.
Her second trip to the Mediterranean came in 1951, 20 March to 5 October, the third, 22 April to 24 October 1953.
During each cruise Macomb participated in the 6th Fleet exercises and operations, lending support to American diplomatic efforts at settling the unstable political situations then existent in many of the Mediterranean countries.
Departing Sasebo, Japan, on 5 December 1945, Macomb steamed for Norfolk, Va., and Atlantic Fleet duty. In June, 1948, Charleston, South Carolina, become her home port, and until September 1949, Macomb went on patrols and took part in exercises along the eastern coasts of the United States and Canada and in the Caribbean. By the 1950s, Macomb had her Torpedo tubes and aft main 5inch gun removed.
On 8 September 1949, Macomb departed Charleston for the first of three brief tours of duty with the 6th Fleet in the Mediterranean. She returned to Charleston on 13 October. Her second trip to the Mediterranean came in 1951, 20 March to 5 October, the third, 22 April to 24 October 1953. During each cruise Macomb participated in the 6th Fleet exercises and operations, lending support to American diplomatic efforts at settling the unstable political situations then existent in many of the Mediterranean countries.
USS Macomb (DD-458)