Between 1163 and 1855, with a population around 6408 (1801), it was the municipal seat of a municipality consisting of Louriceira, Malhou, Alcobertas, Fráguas, Abrã, Alcanede and Arneiro das Milhariças.

During the Roman occupation, the region of Alcanede constituted the western limit of the Santarém colonia; it was a secondary Roman transit roadway.

Afonso Henriques donated the village of Alcanede to Gonçalo Mendes de Sousa, while the ecclesiastical rights were transferred to the Monastery of Coimbra, in 1163, resulting in the construction of a religious temple that records referred to as Santa Maria de Alcanede.
The first prior was Father Fernão Anes (1299).

In 1179, the castle's garrison assisted Fuas Roupinho to defeat Moorish incursions and attacks on the Castle of Porto de Mós, and in 1187 King Sancho I donated the castle in Alcanede to the militia in Évora (the future Order of Aviz).

King Ferdinand had the castle remodelled in 1370, at the same time while the men of Alcanede participated in the public works in the Castle of Santarém.
In 1372, Vasco Fernandes de Camões (descendant of Luís de Camões) was appointed the Alcaide-mor of the Castle of Alcanede, just as the garrison allied itself with the Master of Aviz (per the chronicler Fernão Lopes).

In 1514, King Manuel provided a regal charter (Portuguese: foral).
During the accession crisis, the municipality supported Philip II of Spain, yet for a while, António, Prior of Crato, sought refuge in Alcanede, on his escape from the country.
In July 1679, Father António Vieira stayed in Alcanede, as revealed from his correspondence with diplomat Duarte Ribeiro de Macedo.

On 16 July 1719, the local population revolted against taxes imposed by the Order of Aviz, going as far as marching to Lisbon and receiving a favourable hearing from King John V.
During the third French invasion, between November 1810 and March 1811, the main village is occupied and pillaged by French troops from Massena's 8th Corp.
After the 1820 Liberal revolution, the Municipal Chamber of Alcanede aligned itself with the new regime.
During the Patuleia (1846) Alcanede and its region were sites of many confrontations between Cartistas and Setemberistas forces.
Between 1163 and 1855, with a population around 6408 (1801), it was the municipal seat of a municipality consisting of Louriceira, Malhou, Alcobertas, Fráguas, Abrã, Alcanede and Arneiro das Milhariças.
During the Roman occupation, the region of Alcanede constituted the western limit of the Santarém colonia; it was a secondary Roman transit roadway.
Afonso Henriques donated the village of Alcanede to Gonçalo Mendes de Sousa, while the ecclesiastical rights were transferred to the Monastery of Coimbra, in 1163, resulting in the construction of a religious temple that records referred to as Santa Maria de Alcanede. The first prior was Father Fernão Anes (1299).
In 1179, the castle's garrison assisted Fuas Roupinho to defeat Moorish incursions and attacks on the Castle of Porto de Mós, and in 1187 King Sancho I donated the castle in Alcanede to the militia in Évora (the future Order of Aviz).
King Ferdinand had the castle remodelled in 1370, at the same time while the men of Alcanede participated in the public works in the Castle of Santarém. In 1372, Vasco Fernandes de Camões (descendant of Luís de Camões) was appointed the Alcaide-mor of the Castle of Alcanede, just as the garrison allied itself with the Master of Aviz (per the chronicler Fernão Lopes).
In 1514, King Manuel provided a regal charter (Portuguese: foral). During the accession crisis, the municipality supported Philip II of Spain, yet for a while, António, Prior of Crato, sought refuge in Alcanede, on his escape from the country. In July 1679, Father António Vieira stayed in Alcanede, as revealed from his correspondence with diplomat Duarte Ribeiro de Macedo.
On 16 July 1719, the local population revolted against taxes imposed by the Order of Aviz, going as far as marching to Lisbon and receiving a favourable hearing from King John V.
During the third French invasion, between November 1810 and March 1811, the main village is occupied and pillaged by French troops from Massena's 8th Corp.
After the 1820 Liberal revolution, the Municipal Chamber of Alcanede aligned itself with the new regime. During the Patuleia (1846) Alcanede and its region were sites of many confrontations between Cartistas and Setemberistas forces.
Alcanede