The organization began in 1922 as the Louisiana Highway Commission with 16 Highway Inspectors covering approximately 2,700 miles (4,300 km) of roadway.
These inspectors patrolled exclusively by motorcycles.
 These motorcycles were personally owned by the individual patrolmen, and maintained by an allowance from the state.
 Of the 16 men on the force, one was a captain.
 This captain served as superintendent of the force.
The highway commission was divided into ten districts.
 The Baton Rouge District had two patrol officers, while the New Orleans District had three patrolmen.
 The other eight districts had one patrol officer each.
 The other two officers patrolled statewide on the main highways of the state.
 In 1928 the agency was known as the Law Enforcement Division of the Highway Commission, and employed 70 uniformed officers.
The Bureau of Criminal Investigation was also formed about that time.
In 1932, the organization's name was changed to the State Highway Patrol, and it was given the authority to carry firearms.
The agency was used by Governor Huey Long as his personal bodyguards, who escorted him all over the state.
 In 1936, the two divisions of law enforcement were combined, by an act of the Louisiana Legislature, to form the Louisiana Department of State Police.
The department's force of patrolmen numbered over 40 at that time, and the primary patrol vehicle was the motorcycle.
 In 1939, the State Police was divided into eight "troops".
 Troopers in cars and motorcycles were patrolling nearly 2 million miles per year throughout the state.
 The agency's fleet of patrol motorcycles eventually grew to 64 motorcycles.
 In 1942 the Louisiana Legislature abolished the Department of State Police and made it a division of the newly created Department of Public Safety.
The state police accepted new responsibilities in 1946, when the state's Drivers License Law was enacted requiring every driver to hold a license for operating a motor vehicle.
Prior to this time, only the operators of commercial vehicles, trucks, and buses were required to be licensed in Louisiana.
In 1948, the number of motorcycles operated by the agency had fallen to 36 motorcycles.
 The department was relying more heavily on automobiles for patrol purposes, and eventually patrol motorcycles were only found in New Orleans and other major cities.
 Motorcycle patrol units were used throughout the 1950s, with Governor Earl Kemp Long also using them as bodyguards.
 In the 1960s, the department was utilizing motorcycles, automobiles, airplanes, and helicopters for enforcement purposes.
 The department had exclusively used Harley-Davidson motorcycles until the 1980s when it switched to Kawasaki motorcycles.
 A short time after this switch, the motorcycle patrol program was disbanded.
 In 1997, patrol motorcycles were brought back on the force.
 The agency continued to make advancements with the current number of troopers employed by the department listed as 1,022.

In September 2018, the Louisiana State Police were scrutinized for using lists of personal information about supposed Antifa members which were posted on 8chan's politics board.
The file "antifa.docx" was found in police databases and led directly to the opening of criminal investigations.
The organization began in 1922 as the Louisiana Highway Commission with 16 Highway Inspectors covering approximately 2,700 miles (4,300 km) of roadway. These inspectors patrolled exclusively by motorcycles.  These motorcycles were personally owned by the individual patrolmen, and maintained by an allowance from the state.  Of the 16 men on the force, one was a captain.  This captain served as superintendent of the force. The highway commission was divided into ten districts.  The Baton Rouge District had two patrol officers, while the New Orleans District had three patrolmen.  The other eight districts had one patrol officer each.  The other two officers patrolled statewide on the main highways of the state.  In 1928 the agency was known as the Law Enforcement Division of the Highway Commission, and employed 70 uniformed officers. The Bureau of Criminal Investigation was also formed about that time. In 1932, the organization's name was changed to the State Highway Patrol, and it was given the authority to carry firearms. The agency was used by Governor Huey Long as his personal bodyguards, who escorted him all over the state.  In 1936, the two divisions of law enforcement were combined, by an act of the Louisiana Legislature, to form the Louisiana Department of State Police. The department's force of patrolmen numbered over 40 at that time, and the primary patrol vehicle was the motorcycle.  In 1939, the State Police was divided into eight "troops".  Troopers in cars and motorcycles were patrolling nearly 2 million miles per year throughout the state.  The agency's fleet of patrol motorcycles eventually grew to 64 motorcycles.  In 1942 the Louisiana Legislature abolished the Department of State Police and made it a division of the newly created Department of Public Safety. The state police accepted new responsibilities in 1946, when the state's Drivers License Law was enacted requiring every driver to hold a license for operating a motor vehicle. Prior to this time, only the operators of commercial vehicles, trucks, and buses were required to be licensed in Louisiana. In 1948, the number of motorcycles operated by the agency had fallen to 36 motorcycles.  The department was relying more heavily on automobiles for patrol purposes, and eventually patrol motorcycles were only found in New Orleans and other major cities.  Motorcycle patrol units were used throughout the 1950s, with Governor Earl Kemp Long also using them as bodyguards.  In the 1960s, the department was utilizing motorcycles, automobiles, airplanes, and helicopters for enforcement purposes.  The department had exclusively used Harley-Davidson motorcycles until the 1980s when it switched to Kawasaki motorcycles.  A short time after this switch, the motorcycle patrol program was disbanded.  In 1997, patrol motorcycles were brought back on the force.  The agency continued to make advancements with the current number of troopers employed by the department listed as 1,022.
In September 2018, the Louisiana State Police were scrutinized for using lists of personal information about supposed Antifa members which were posted on 8chan's politics board. The file "antifa.docx" was found in police databases and led directly to the opening of criminal investigations.
Louisiana State Police