On 20 August 1688, at the age of 15, Louise Elizabeth married Duke Philip of Saxe-Merseburg-Lauchstädt as his second wife.
He was 31 years old and was an elder brother of her stepmother Marie Sibylle.
A medal was struck to commemorate their marriage.
After the wedding, the couple resided in Merseburg, where their son Christian Louis was born on 21 July 1689.
One year later (1690) and within days, she lost both her son (6 June) and her husband, when he fell during the Battle of Fleurus on 1 July.
Louise Elisabeth had followed her husband to Fleurus, and the camp where she stayed was attacked by the French.
Afterwards, she had trouble journeying back to Merseburg and thence to Lauchstädt.

In 1704, her father died.
That same year, she moved from Lauchstädt Castle to her widow seat in Forst.
The castle in Forst had been uninhabited since Ferdinand II of Bieberstein, its last inhabitant, had died in 1667.
She had it renewed and expanded and added a chapel.
The great hall above the entrance gate was used as the castle chapel.
Her court was managed by her High Hofmeister Carl Gottlob von Goldstein auf Passendorf und Angersdorf hsi wife, Christian Sibylle née Marschall von Bierberstein assisted by two more Hofmeisters, Otto Heinrich von Vibra and Bodo Gottlieb von Koseritz.
Her equerry was Hans Günther von Bomsdorf auf Weissagk, and after his death, a Baron von Lossow.
She also employed several Chambermaids, quite a few pages, a court deacon, a chaplain, a personal physician, and after 1710 a court cantor, who also supervised the pages, and a catechist, who assisted the chaplain and educated the children of her staff.
She further employed a conductor and several musicians, most of whom were also lackeys, a chamber singer, a female court midget, a court manager, a quartermaster, a gardener, and a number of servants with all sorts of job titles.

In 1709, she revived the Ducal Württemberg-Oels Order of the Skull as a chivalric order for ladies.
 Also in 1709, the first post office opened in Forst.
It was housed in her palace, because of her commitment
Between 1717 and 1721, her small court orchestra was directed by Christian August Jacobi (1688 – after 1725).
In 1718, he composed his Christmas cantata Der Himmel steht uns wieder offen for tenor solo, string emsemble, trumpet and basso continuo, first performed on Christmas Day 1718 in the court chapel.
 This cantata is considered representative of the Saxon baroque music and is still performed occasionally in the Frauenkirche in Dresden.

She lived in Forst until her death; she died on 28 April 1736.
She was buried in the crypt of the St. Nicholas church in Forst (Lausitz).
On 20 August 1688, at the age of 15, Louise Elizabeth married Duke Philip of Saxe-Merseburg-Lauchstädt as his second wife. He was 31 years old and was an elder brother of her stepmother Marie Sibylle. A medal was struck to commemorate their marriage. After the wedding, the couple resided in Merseburg, where their son Christian Louis was born on 21 July 1689. One year later (1690) and within days, she lost both her son (6 June) and her husband, when he fell during the Battle of Fleurus on 1 July. Louise Elisabeth had followed her husband to Fleurus, and the camp where she stayed was attacked by the French. Afterwards, she had trouble journeying back to Merseburg and thence to Lauchstädt.
In 1704, her father died. That same year, she moved from Lauchstädt Castle to her widow seat in Forst. The castle in Forst had been uninhabited since Ferdinand II of Bieberstein, its last inhabitant, had died in 1667. She had it renewed and expanded and added a chapel. The great hall above the entrance gate was used as the castle chapel. Her court was managed by her High Hofmeister Carl Gottlob von Goldstein auf Passendorf und Angersdorf hsi wife, Christian Sibylle née Marschall von Bierberstein assisted by two more Hofmeisters, Otto Heinrich von Vibra and Bodo Gottlieb von Koseritz. Her equerry was Hans Günther von Bomsdorf auf Weissagk, and after his death, a Baron von Lossow. She also employed several Chambermaids, quite a few pages, a court deacon, a chaplain, a personal physician, and after 1710 a court cantor, who also supervised the pages, and a catechist, who assisted the chaplain and educated the children of her staff. She further employed a conductor and several musicians, most of whom were also lackeys, a chamber singer, a female court midget, a court manager, a quartermaster, a gardener, and a number of servants with all sorts of job titles.
In 1709, she revived the Ducal Württemberg-Oels Order of the Skull as a chivalric order for ladies.  Also in 1709, the first post office opened in Forst. It was housed in her palace, because of her commitment
Between 1717 and 1721, her small court orchestra was directed by Christian August Jacobi (1688 – after 1725). In 1718, he composed his Christmas cantata Der Himmel steht uns wieder offen for tenor solo, string emsemble, trumpet and basso continuo, first performed on Christmas Day 1718 in the court chapel.  This cantata is considered representative of the Saxon baroque music and is still performed occasionally in the Frauenkirche in Dresden.
She lived in Forst until her death; she died on 28 April 1736. She was buried in the crypt of the St. Nicholas church in Forst (Lausitz).
Louise Elisabeth of Württemberg-Oels