Starting in 1957, the 28th Bombardment Wing at Ellsworth Air Force Base began to upgrade from the Convair B-36 Peacemaker to the Boeing B-52 Stratofortress.
 However, Strategic Air Command (SAC)  was concerned that bases with large concentrations of the new jet bombers made attractive targets.
 SAC's response was to break up its B-52 wings and scatter their aircraft over a larger number of bases, thus making it more difficult for the Soviet Union to knock out the entire fleet with a surprise first strike.
 At the same time, the reduced number of interceptors available to Air Defense Command (ADC) due to attrition and closing production lines made ADC bases along the northern tier of states available for expansion to accommodate SAC heavy bombers and tankers.
 In 1958 SAC established strategic wings at Grand Forks Air Force Base, North Dakota, Minot Air Force Base, North Dakota, and Glasgow Air Force Base, Montana, all ADC bases.
The 821st Air Division was activated at Ellsworth in January 1959 to command these new strategic wings and the 28th Wing at Ellsworth.

However, the establishment of wings did not immediately disperse the bomber force.
 It would be 1960 before the 28th Wing's 717th and 718th Bombardment Squadrons were transferred from Ellsworth to other bases.
 Although Boeing KC-135 Stratotankers were assigned earlier, Minot and Glasgow only received their bombers in 1961 and the Grand Forks wing only activated its bomber squadron in 1962.
 As their squadrons became combat ready, one third of each wing's aircraft were maintained on fifteen-minute alert, fully fueled, armed and ready for combat to reduce vulnerability to a Soviet missile strike.
 This was increased to half their aircraft in 1962.

In December 1960, the division added an intercontinental ballistic missile squadron to its strike forces, when the 850th Strategic Missile Squadron was activated and assigned to the 28th Bombardment Wing as an HGM-25A Titan I squadron.
 However, the squadron never became operational while assigned to the 28th.

1962 was a year of change for the division's responsibilities.
 On 1 January, the 44th Strategic Missile Wing was activated at Ellsworth and assigned to the 821st.
 The 850th Strategic Missile Squadron was assigned to the new wing.
   The same day, the division assumed support responsibility for Ellsworth through its 821st Combat Support Group.
 The following month, the division became the 821st Strategic Aerospace Division when SAC added the term "aerospace" to the names of its units with both bomber and missile strike elements.

Although the 44th wing was initially assigned Titan I missiles, it was designed as a LGM-30A Minuteman I wing and began to add Minuteman squadrons in the summer of 1962, although none became operational until 1963.
  In July, the division's responsibilities were realigned when the three strategic wings were reassigned to other SAC divisions and the 821st assumed command of a second Minuteman wing, the 341st Strategic Missile Wing at Malmstrom Air Force Base, Montana.
 On 23 July, the 341st's first Minuteman was placed in its silo.

On 23 October 1962, in response to the Cuban Missile Crisis, the 341st placed its first two Minuteman missiles on alert.
 The 341st was in the process of accepting their first flight of missiles from Air Force Systems Command.
Eventually Malmstrom was able to place six missiles on alert for the duration of the crisis.
These were the first and only SAC Minutemen to stand alert during the crisis.
 On 20 October SAC had directed its B-52 wings, including the 28th, to put two additional planes on alert.
Two days later 1/8 of the division's B-52s were placed on airborne alert.
 Additional KC-135s were also placed on alert to replace the KC-135s devoted to maintaining the B-52 airborne alert.
 On 24 October SAC increased its readiness status to DEFCON 2, placing all its combat aircraft on alert.
On 21 November SAC returned to normal airborne alert posture.
and on 27 November SAC returned to normal ground alert posture.

The division lost the first Minuteman wing, the 341
Starting in 1957, the 28th Bombardment Wing at Ellsworth Air Force Base began to upgrade from the Convair B-36 Peacemaker to the Boeing B-52 Stratofortress.  However, Strategic Air Command (SAC)  was concerned that bases with large concentrations of the new jet bombers made attractive targets.  SAC's response was to break up its B-52 wings and scatter their aircraft over a larger number of bases, thus making it more difficult for the Soviet Union to knock out the entire fleet with a surprise first strike.  At the same time, the reduced number of interceptors available to Air Defense Command (ADC) due to attrition and closing production lines made ADC bases along the northern tier of states available for expansion to accommodate SAC heavy bombers and tankers.  In 1958 SAC established strategic wings at Grand Forks Air Force Base, North Dakota, Minot Air Force Base, North Dakota, and Glasgow Air Force Base, Montana, all ADC bases. The 821st Air Division was activated at Ellsworth in January 1959 to command these new strategic wings and the 28th Wing at Ellsworth.
However, the establishment of wings did not immediately disperse the bomber force.  It would be 1960 before the 28th Wing's 717th and 718th Bombardment Squadrons were transferred from Ellsworth to other bases.  Although Boeing KC-135 Stratotankers were assigned earlier, Minot and Glasgow only received their bombers in 1961 and the Grand Forks wing only activated its bomber squadron in 1962.  As their squadrons became combat ready, one third of each wing's aircraft were maintained on fifteen-minute alert, fully fueled, armed and ready for combat to reduce vulnerability to a Soviet missile strike.  This was increased to half their aircraft in 1962.
In December 1960, the division added an intercontinental ballistic missile squadron to its strike forces, when the 850th Strategic Missile Squadron was activated and assigned to the 28th Bombardment Wing as an HGM-25A Titan I squadron.  However, the squadron never became operational while assigned to the 28th.
1962 was a year of change for the division's responsibilities.  On 1 January, the 44th Strategic Missile Wing was activated at Ellsworth and assigned to the 821st.  The 850th Strategic Missile Squadron was assigned to the new wing.    The same day, the division assumed support responsibility for Ellsworth through its 821st Combat Support Group.  The following month, the division became the 821st Strategic Aerospace Division when SAC added the term "aerospace" to the names of its units with both bomber and missile strike elements.
Although the 44th wing was initially assigned Titan I missiles, it was designed as a LGM-30A Minuteman I wing and began to add Minuteman squadrons in the summer of 1962, although none became operational until 1963.   In July, the division's responsibilities were realigned when the three strategic wings were reassigned to other SAC divisions and the 821st assumed command of a second Minuteman wing, the 341st Strategic Missile Wing at Malmstrom Air Force Base, Montana.  On 23 July, the 341st's first Minuteman was placed in its silo.
On 23 October 1962, in response to the Cuban Missile Crisis, the 341st placed its first two Minuteman missiles on alert.  The 341st was in the process of accepting their first flight of missiles from Air Force Systems Command. Eventually Malmstrom was able to place six missiles on alert for the duration of the crisis. These were the first and only SAC Minutemen to stand alert during the crisis.  On 20 October SAC had directed its B-52 wings, including the 28th, to put two additional planes on alert. Two days later 1/8 of the division's B-52s were placed on airborne alert.  Additional KC-135s were also placed on alert to replace the KC-135s devoted to maintaining the B-52 airborne alert.  On 24 October SAC increased its readiness status to DEFCON 2, placing all its combat aircraft on alert. On 21 November SAC returned to normal airborne alert posture. and on 27 November SAC returned to normal ground alert posture.
The division lost the first Minuteman wing, the 341
821st Strategic Aerospace Division