To start the 2009–10 season, Moore was named a preseason candidate for the John R. Wooden Award along with teammate, Robbie Hummel.
With a 22-point performance against Tennessee and being named the 2009 Paradise Jam Tournament MVP, he became the 43rd Boilermaker to score his 1,000th career point.
He helped lead Purdue to a 14–0 season start, which tied the Glenn Robinson-led 1993–94 team as the best start in school history.
He was named to the District 5 First Team Academic All-District Team, as selected by ESPN The Magazine and College Sports Information Directors of America, making him one of 40 finalists for the 15-man Academic All-American team, in which he was eventually selected as a Second Team Academic All-American.
Moore had a 28-game double-digit scoring streak that extended from November 20 – March 3.
The streak consisted of eight 20+ point performances, which included a career high 28 points on March 12, 2010, in the quarterfinals of the 2009 Big Ten Conference Men's Basketball Tournament against Northwestern.
Leading Purdue in scoring with 16.5 points a game and shooting beyond the arc at 34.3 percent, he was also second on the team with 2.7 assists per outing behind Lewis Jackson's 3.5 mark.
With a 14–4 record in conference play, Moore helped Purdue to its share of the first Big Ten Conference regular season title in fourteen years.
Moore was named a First Team All-Big Ten selection by both the coaches and the media at the conclusion of the regular season.
He was selected by the U.S. Basketball Writers Association to the 10-man All-District V team covering college basketball players in the states of Ohio, Indiana, Illinois, Michigan, Minnesota, and Wisconsin.
Moore was a Third-Team All-American selection by Yahoo!
Sports and an Honorable Mention All-American by the Associated Press.,
while being recognized as an All-District First-Team selection by the National Association of Basketball Coaches.
Moore led Purdue to a 4 seed in the NCAA Tournament, culminating with a consecutive Sweet Sixteen after beating Siena and Texas A&M. Eventually losing to Duke for the second time in his career, he led Purdue to a 29–6 record, which tied for the most season wins in school history.
He concluded the season sixth in the Big Ten Conference in scoring (teammates Hummel and Johnson finished seventh and eighth) and ninth in steals.
With 93 assists to go along with his scoring, he is only the third boilermaker to lead the team in total points and assists since Larry Weatherford did in the 1970–1971 season.
He is the first person to lead the team in scoring three straight seasons since Troy Lewis did in the late-eightees.
He earned repeat recognition as an Academic All-Big Ten selection.
To start the 2009–10 season, Moore was named a preseason candidate for the John R. Wooden Award along with teammate, Robbie Hummel. With a 22-point performance against Tennessee and being named the 2009 Paradise Jam Tournament MVP, he became the 43rd Boilermaker to score his 1,000th career point. He helped lead Purdue to a 14–0 season start, which tied the Glenn Robinson-led 1993–94 team as the best start in school history. He was named to the District 5 First Team Academic All-District Team, as selected by ESPN The Magazine and College Sports Information Directors of America, making him one of 40 finalists for the 15-man Academic All-American team, in which he was eventually selected as a Second Team Academic All-American. Moore had a 28-game double-digit scoring streak that extended from November 20 – March 3. The streak consisted of eight 20+ point performances, which included a career high 28 points on March 12, 2010, in the quarterfinals of the 2009 Big Ten Conference Men's Basketball Tournament against Northwestern. Leading Purdue in scoring with 16.5 points a game and shooting beyond the arc at 34.3 percent, he was also second on the team with 2.7 assists per outing behind Lewis Jackson's 3.5 mark. With a 14–4 record in conference play, Moore helped Purdue to its share of the first Big Ten Conference regular season title in fourteen years. Moore was named a First Team All-Big Ten selection by both the coaches and the media at the conclusion of the regular season. He was selected by the U.S. Basketball Writers Association to the 10-man All-District V team covering college basketball players in the states of Ohio, Indiana, Illinois, Michigan, Minnesota, and Wisconsin. Moore was a Third-Team All-American selection by Yahoo! Sports and an Honorable Mention All-American by the Associated Press., while being recognized as an All-District First-Team selection by the National Association of Basketball Coaches. Moore led Purdue to a 4 seed in the NCAA Tournament, culminating with a consecutive Sweet Sixteen after beating Siena and Texas A&M. Eventually losing to Duke for the second time in his career, he led Purdue to a 29–6 record, which tied for the most season wins in school history. He concluded the season sixth in the Big Ten Conference in scoring (teammates Hummel and Johnson finished seventh and eighth) and ninth in steals. With 93 assists to go along with his scoring, he is only the third boilermaker to lead the team in total points and assists since Larry Weatherford did in the 1970–1971 season. He is the first person to lead the team in scoring three straight seasons since Troy Lewis did in the late-eightees. He earned repeat recognition as an Academic All-Big Ten selection.
E'Twaun Moore