The watershed of Chillisquaque Creek has an area of 112 square miles (290 km²).
The mouth of the creek is in the United States Geological Survey quadrangle of Northumberland.
However, its source is in the quadrangle of Washingtonville.
The creek also passes through the quadrangle of Milton.
The creek can be accessed from Pennsylvania Route 45, Pennsylvania Route 405, and Pennsylvania Route 642.

The watershed of Chillisquaque Creek parts of four counties: Montour County, Northumberland County, Columbia County, and Lycoming County.
The portion of Montour County that is in the watershed is the central portion.
It is the largest watershed in that county, accounting for 56 percent of its land area.
It is also the only large stream in northern Northumberland County.
There are about 260 miles (420 km) of streams in the watershed.

The land alongside Chillisquaque Creek is mainly used for farming.
As of the 1980s, the main crops are corn and soybeans.

There is a gauging station on Chillisquaque Creek at Washingtonville.
The area of the creek's watershed upstream of this point is 51.3 square miles (133 km²).
A reservoir known as Lake Chillisquaque is located on the tributary Middle Branch Chillisquaque Creek in Anthony Township, Montour County.
It is the largest lake/reservoir in Montour County, with an area of 165 acres (67 ha).
There are two dams in the watershed: the Lake Chillisquaque dam and the Montour Ash Basin No 1 dam.
Both were built in 1971.
The former drains an area of 5.6 square miles (15 km²), while the latter drains an area of 0.2 square miles (0.52 km²).
The watershed of Chillisquaque Creek has an area of 112 square miles (290 km²). The mouth of the creek is in the United States Geological Survey quadrangle of Northumberland. However, its source is in the quadrangle of Washingtonville. The creek also passes through the quadrangle of Milton. The creek can be accessed from Pennsylvania Route 45, Pennsylvania Route 405, and Pennsylvania Route 642.
The watershed of Chillisquaque Creek parts of four counties: Montour County, Northumberland County, Columbia County, and Lycoming County. The portion of Montour County that is in the watershed is the central portion. It is the largest watershed in that county, accounting for 56 percent of its land area. It is also the only large stream in northern Northumberland County. There are about 260 miles (420 km) of streams in the watershed.
The land alongside Chillisquaque Creek is mainly used for farming. As of the 1980s, the main crops are corn and soybeans.
There is a gauging station on Chillisquaque Creek at Washingtonville. The area of the creek's watershed upstream of this point is 51.3 square miles (133 km²). A reservoir known as Lake Chillisquaque is located on the tributary Middle Branch Chillisquaque Creek in Anthony Township, Montour County. It is the largest lake/reservoir in Montour County, with an area of 165 acres (67 ha). There are two dams in the watershed: the Lake Chillisquaque dam and the Montour Ash Basin No 1 dam. Both were built in 1971. The former drains an area of 5.6 square miles (15 km²), while the latter drains an area of 0.2 square miles (0.52 km²).
Chillisquaque Creek