By the 1960s, traffic congestion was a major problem in Stoke-on-Trent, and journeys across the area sometimes took hours.
 There was no connection from the newly constructed M6 to the city.
Businesses in the area wanted an easier route to get their goods out of the area.

The A500 was initially built from the M6 at junction 16 to the A34 road at Talke as part of the motorway construction, opening in 1962.
 At the southern end, a dual carriageway was constructed from junction 15 of the M6 to the A34 near Trentham, given the number A5006, and opened at the same time.
 The northern section of the road was then subsequently extended from Talke to the A53 road.
 The final section from the A34 in the south to the A53 junction was built between 1974 and 1977.
  The two middle junctions were to be grade separated, but due to financial constraints they were built as roundabouts.
Construction involved the destruction of streets and businesses within Stoke's town centre, as well as the excavation of a mass grave of the victims of a 17th-century cholera epidemic.
This final section was named Queensway, and on its completion the whole route became the A500.

The route remained unchanged until the 1980s when the Hanford Roundabout junction had a flyover built, as this was a major bottleneck for both the A500 and A34.
 The 1977 section east of this junction had been built with provision for the bridge, but the section built as the A5006 required realignment for the new interchange.
 In the late 1980s the road was extended from Junction 16 close to Weston with connections provided to existing roads to Keele and Crewe.
 The A52, which at that time ran to Nantwich, was renumbered from Newcastle to Weston as a B road and the section from Weston to Nantwich was incorporated into the A500.
In 1989 a bypass to the east of Nantwich was opened, extending the A500 from the south of Nantwich to its current northerly terminus with the A51.

In 1993 a proposal was made to add the missing flyover and underpass close to Stoke-on-Trent railway station, after an alternative plan had been rejected because of its cost.
A full review of the national roads programme resulted in the suspension of that scheme however.
 In 1997 the A50 was rerouted through Stoke-on-Trent to meet the A500 at Sideway, where a new grade separated roundabout was constructed.

On the approach to Hough was a narrow single lane bridge which was added to with a Bailey bridge in 1993.
In September 2003, the Shavington bypass opened to reroute the road away from three villages on the former A52 section.
 This was built to dual carriageway standards with provision for further junctions to new development sites.

Traffic continued to rise to the point where major congestion was experienced on the central section.
Work began on 16 February 2004 on the A500 Pathfinder Project to replace the final two roundabouts in Stoke with underpasses.
 The Highways Agency defined the pathfinder project as involving "a new form of contract and co-operative working methods to deliver a better value project, faster."
 The project involved alterations to the path of the Trent and Mersey Canal and River Trent, along with new provisions for pedestrians.
The work was carried out by Edmund Nuttall Limited and was planned to be completed in spring 2006.
Following a number of delays for which it was rumoured the construction company was being fined up to £100,000 a day for not keeping to schedule, the road opened on Tuesday 26 September 2006, with the southbound traffic in the morning and northbound traffic in the afternoon.
 Several months of additional work was needed to finalise traffic light operations, gardens, and other miscellaneous tasks.

In February 2009, it was announced that the single carriageway Nantwich bypass would be re-numbered as the A51 in a bid to relieve the town centre of traffic.

In 2015, the final 500m of the eastbound single carriageway between Weston and Junction 16 of the M6 was upgraded.
 This included resignalling works on the roundabout in order to relieve congestion at the roundabout.
By the 1960s, traffic congestion was a major problem in Stoke-on-Trent, and journeys across the area sometimes took hours.  There was no connection from the newly constructed M6 to the city. Businesses in the area wanted an easier route to get their goods out of the area.
The A500 was initially built from the M6 at junction 16 to the A34 road at Talke as part of the motorway construction, opening in 1962.  At the southern end, a dual carriageway was constructed from junction 15 of the M6 to the A34 near Trentham, given the number A5006, and opened at the same time.  The northern section of the road was then subsequently extended from Talke to the A53 road.  The final section from the A34 in the south to the A53 junction was built between 1974 and 1977.   The two middle junctions were to be grade separated, but due to financial constraints they were built as roundabouts. Construction involved the destruction of streets and businesses within Stoke's town centre, as well as the excavation of a mass grave of the victims of a 17th-century cholera epidemic. This final section was named Queensway, and on its completion the whole route became the A500.
The route remained unchanged until the 1980s when the Hanford Roundabout junction had a flyover built, as this was a major bottleneck for both the A500 and A34.  The 1977 section east of this junction had been built with provision for the bridge, but the section built as the A5006 required realignment for the new interchange.  In the late 1980s the road was extended from Junction 16 close to Weston with connections provided to existing roads to Keele and Crewe.  The A52, which at that time ran to Nantwich, was renumbered from Newcastle to Weston as a B road and the section from Weston to Nantwich was incorporated into the A500. In 1989 a bypass to the east of Nantwich was opened, extending the A500 from the south of Nantwich to its current northerly terminus with the A51.
In 1993 a proposal was made to add the missing flyover and underpass close to Stoke-on-Trent railway station, after an alternative plan had been rejected because of its cost. A full review of the national roads programme resulted in the suspension of that scheme however.  In 1997 the A50 was rerouted through Stoke-on-Trent to meet the A500 at Sideway, where a new grade separated roundabout was constructed.
On the approach to Hough was a narrow single lane bridge which was added to with a Bailey bridge in 1993. In September 2003, the Shavington bypass opened to reroute the road away from three villages on the former A52 section.  This was built to dual carriageway standards with provision for further junctions to new development sites.
Traffic continued to rise to the point where major congestion was experienced on the central section. Work began on 16 February 2004 on the A500 Pathfinder Project to replace the final two roundabouts in Stoke with underpasses.  The Highways Agency defined the pathfinder project as involving "a new form of contract and co-operative working methods to deliver a better value project, faster."  The project involved alterations to the path of the Trent and Mersey Canal and River Trent, along with new provisions for pedestrians. The work was carried out by Edmund Nuttall Limited and was planned to be completed in spring 2006. Following a number of delays for which it was rumoured the construction company was being fined up to £100,000 a day for not keeping to schedule, the road opened on Tuesday 26 September 2006, with the southbound traffic in the morning and northbound traffic in the afternoon.  Several months of additional work was needed to finalise traffic light operations, gardens, and other miscellaneous tasks.
In February 2009, it was announced that the single carriageway Nantwich bypass would be re-numbered as the A51 in a bid to relieve the town centre of traffic.
In 2015, the final 500m of the eastbound single carriageway between Weston and Junction 16 of the M6 was upgraded.  This included resignalling works on the roundabout in order to relieve congestion at the roundabout.
A500 road