His twelve children with Cecily Neville are:
Anne of York (10 August 1439 – 14 January 1476).
Married to Henry Holland, 3rd Duke of Exeter and Thomas St. Leger.

Henry of York (10 February 1441, Hatfield; died young).

Edward IV of England (28 April 1442 – 9 April 1483).
Married to Elizabeth Woodville.

Edmund, Earl of Rutland (17 May 1443 – 30 December 1460).

Elizabeth of York (22 April 1444 – after January 1503).
Married to John de la Pole, 2nd Duke of Suffolk (his first marriage, later annulled, had been to Lady Margaret Beaufort when she was about 3 years old).

Margaret of York (3 May 1446 – 23 November 1503).
Married to Charles the Bold, Duke of Burgundy.

William of York (born 7 July 1447, died young).

John of York (born 7 November 1448, died young).

George, Duke of Clarence (21 October 1449 – 18 February 1478).
Married to Lady Isabel Neville.
Parents of Lady Margaret Pole, Countess of Salisbury.

Thomas of York (born c. 1451, died young).

Richard III of England (2 October 1452 – 22 August 1485).
Married to Lady Anne Neville, the sister of Lady Isabel, Duchess of Clarence.

Ursula of York (born 22 July 1455, died young).
His twelve children with Cecily Neville are:
Anne of York (10 August 1439 – 14 January 1476). Married to Henry Holland, 3rd Duke of Exeter and Thomas St. Leger.
Henry of York (10 February 1441, Hatfield; died young).
Edward IV of England (28 April 1442 – 9 April 1483). Married to Elizabeth Woodville.
Edmund, Earl of Rutland (17 May 1443 – 30 December 1460).
Elizabeth of York (22 April 1444 – after January 1503). Married to John de la Pole, 2nd Duke of Suffolk (his first marriage, later annulled, had been to Lady Margaret Beaufort when she was about 3 years old).
Margaret of York (3 May 1446 – 23 November 1503). Married to Charles the Bold, Duke of Burgundy.
William of York (born 7 July 1447, died young).
John of York (born 7 November 1448, died young).
George, Duke of Clarence (21 October 1449 – 18 February 1478). Married to Lady Isabel Neville. Parents of Lady Margaret Pole, Countess of Salisbury.
Thomas of York (born c. 1451, died young).
Richard III of England (2 October 1452 – 22 August 1485). Married to Lady Anne Neville, the sister of Lady Isabel, Duchess of Clarence.
Ursula of York (born 22 July 1455, died young).
Richard of York, 3rd Duke of York