McClure's acting career included such films as The Enemy Below, The Unforgiven and Because They're Young, then he landed the role of Trampas on The Virginian, a role that would make him famous.
He also starred:
As C.R. (Christopher Robin) Grover in the sci-fi/detective series Search (1972–1973), in which he rotated the lead with Hugh O'Brian and Anthony Franciosa as a high-tech PROBE agent.

As Cash Conover, casino owner, co-starring with William Shatner, in the one-season series The Barbary Coast (1975–1976).
McClure replaced Dennis Cole who played the role of Conover in the show's pilot.

As Mayor Kyle Applegate on the fantasy sitcom Out of This World (1987–1991).

McClure had a minor role in 1957 as an Army officer in "California Gold Rush in Reverse" on the anthology series Death Valley Days.
The episode is a dramatization of the race in 1848 between the Army and the Navy to be the first to deliver gold nuggets from California to Washington, D.C.
In 1958 and 1959, McClure appeared in three episodes of the series 26 Men, stories of the Arizona Rangers.

 
McClure was in the third episode "Mr. Denton on Doomsday" of CBS's The Twilight Zone.

In 1962, he was cast as Trampas on NBC's The Virginian.
His co-stars throughout the series were James Drury, Roberta Shore, Lee J. Cobb, Randy Boone, Gary Clarke, Clu Gulager, Diane Roter, Charles Bickford, Sara Lane, Tim Matheson, Jeanette Nolan and John McIntire.

In 1965, he appeared in Shenandoah, a movie directed by Andrew V. McLaglen and starring James Stewart, Glenn Corbett, Patrick Wayne, Katharine Ross and Rosemary Forsyth.

After The Virginian ended in 1971, McClure was slated to co-star with Bette Davis on a series about a parolee assisting a judge, played by Davis, by doing detective work.
The pilot, produced and written by the team of Richard Levinson and William Link, failed to generate interest in the series and was released as a TV movie titled The Judge and Jake Wyler.
McClure made another attempt at a television series during the 1972–1973 season by co-starring on SEARCH as a hi-tech investigator, rotating with Anthony Franciosa and Hugh O'Brian, and again in 1975–1976 in The Barbary Coast, co-starring William Shatner (with whom he'd starred in The Virginian episode "The Claim").
He shifted to low-budget science fiction movies such as At the Earth's Core, The Land That Time Forgot and The People That Time Forgot, all three based on the novels of Edgar Rice Burroughs.
In 1967, he played the Errol Flynn role in a remake of Against All Flags titled The King's Pirate.
He was cast in the lead in three adventures: The Longest Hundred Miles, The Birdmen, and State of Division (also known as Death Race).
In the 1970s and 1980s, McClure appeared in commercials for Hamms Beer.
McClure also appeared as the blonde slave to Jamie Farr's character in the sequel Cannonball Run II (1984).

He also had a cameo role as a poker player in the 1994 remake of Maverick.

In 1994, McClure was awarded a star on the Hollywood Walk of Fame for television at 7065 Hollywood Blvd.
It was unveiled in what was his final public appearance.
McClure's acting career included such films as The Enemy Below, The Unforgiven and Because They're Young, then he landed the role of Trampas on The Virginian, a role that would make him famous. He also starred:
As C.R. (Christopher Robin) Grover in the sci-fi/detective series Search (1972–1973), in which he rotated the lead with Hugh O'Brian and Anthony Franciosa as a high-tech PROBE agent.
As Cash Conover, casino owner, co-starring with William Shatner, in the one-season series The Barbary Coast (1975–1976). McClure replaced Dennis Cole who played the role of Conover in the show's pilot.
As Mayor Kyle Applegate on the fantasy sitcom Out of This World (1987–1991).
McClure had a minor role in 1957 as an Army officer in "California Gold Rush in Reverse" on the anthology series Death Valley Days. The episode is a dramatization of the race in 1848 between the Army and the Navy to be the first to deliver gold nuggets from California to Washington, D.C.
In 1958 and 1959, McClure appeared in three episodes of the series 26 Men, stories of the Arizona Rangers.
 
McClure was in the third episode "Mr. Denton on Doomsday" of CBS's The Twilight Zone.
In 1962, he was cast as Trampas on NBC's The Virginian. His co-stars throughout the series were James Drury, Roberta Shore, Lee J. Cobb, Randy Boone, Gary Clarke, Clu Gulager, Diane Roter, Charles Bickford, Sara Lane, Tim Matheson, Jeanette Nolan and John McIntire.
In 1965, he appeared in Shenandoah, a movie directed by Andrew V. McLaglen and starring James Stewart, Glenn Corbett, Patrick Wayne, Katharine Ross and Rosemary Forsyth.
After The Virginian ended in 1971, McClure was slated to co-star with Bette Davis on a series about a parolee assisting a judge, played by Davis, by doing detective work. The pilot, produced and written by the team of Richard Levinson and William Link, failed to generate interest in the series and was released as a TV movie titled The Judge and Jake Wyler. McClure made another attempt at a television series during the 1972–1973 season by co-starring on SEARCH as a hi-tech investigator, rotating with Anthony Franciosa and Hugh O'Brian, and again in 1975–1976 in The Barbary Coast, co-starring William Shatner (with whom he'd starred in The Virginian episode "The Claim"). He shifted to low-budget science fiction movies such as At the Earth's Core, The Land That Time Forgot and The People That Time Forgot, all three based on the novels of Edgar Rice Burroughs. In 1967, he played the Errol Flynn role in a remake of Against All Flags titled The King's Pirate. He was cast in the lead in three adventures: The Longest Hundred Miles, The Birdmen, and State of Division (also known as Death Race). In the 1970s and 1980s, McClure appeared in commercials for Hamms Beer. McClure also appeared as the blonde slave to Jamie Farr's character in the sequel Cannonball Run II (1984).
He also had a cameo role as a poker player in the 1994 remake of Maverick.
In 1994, McClure was awarded a star on the Hollywood Walk of Fame for television at 7065 Hollywood Blvd. It was unveiled in what was his final public appearance.
Doug McClure