Pruett was racing for Chip Ganassi in the Grand-Am Series during the 2010 season.
In July, Hendrick Motorsports chose him as a standby driver should Jeff Gordon have to miss Watkins Glen due to the birth of his son.
Pruett, combined with Memo Rojas, won 9 of 12 races to win another Grand-Am Rolex Championship.
 The nine victories was a series record.

In 2011, Pruett won the 24 Hours of Daytona, his fourth overall victory in the event.

In 2012, Pruett was one of the commentators for Speed Channel's coverage of the 24 Hours of Le Mans.

Pruett once again led Ganassi Racing to their 3rd Rolex Series Championship in-a-row with Co-driver Memo Rojas.
The team put the No.
01 Telmex BMW Riley on the podium for 9 out of 14 races, top five for 10 out of 14 races with only 2 wins on the season, besting 2nd place Ryan Dalziel by 12 points.
This year's results mark Ganassi's 4th title in 5 years, and Pruett's 5th Rolex title.

In 2013 Pruett opened on a strong note, winning the 51st Rolex 24 at Daytona with co-drivers Memo Rojas, Juan Pablo Montoya, and Charlie Kimball.
2013 marks his fifth win at the annual endurance race, tying the legendary Hurley Haywood for most victories in the grueling twice around the clock race.
 Despite some serious set-backs during the 2013 season, including accruing 0 points at Detroit, the Championship came down to the last race, with the 01 Ganassi Team taking the Team Title, but Jordan Taylor and Max Angelelli taking the Driver's Title under Wayne Taylor Racing/Velocity Worldwide, with Pruett and Rojas taking 2nd place in the Driver's Standings.

In 2014, Pruett competed in the Tudor United SportsCar Championship for a full season with longtime co-driver Memo Rojas in the Prototype Class.

In 2015 Joey Hand joined Pruett in the 01 for the full season.
 The team saw some very disappointing results early in the year due to the aging Riley chassis being outclassed by the Corvette Daytona Prototype.
 However, despite not having won a race until late in the season, the 01 had remained consistent enough to be in the championship battle by the last race of the season Petit Le Mans.
 By the end of the rain-shortened race only 8 points separated the top 4 teams with CGR taking the top spot.

Pruett departed CGR in 2016 and joined with Paul Gentilozzi, who fielded a Lexus RC F GT3 in the WeatherTech SportsCar Championship.
The team was not ready for competition until sometime after the 12 Hours of Sebring.
He later announced that he would be driving for Action Express Racing part-time for the season.

On January 5, 2018, Pruett announced his retirement after 50 years in racing, following the 2018 Rolex 24 at Daytona.
Pruett was racing for Chip Ganassi in the Grand-Am Series during the 2010 season. In July, Hendrick Motorsports chose him as a standby driver should Jeff Gordon have to miss Watkins Glen due to the birth of his son. Pruett, combined with Memo Rojas, won 9 of 12 races to win another Grand-Am Rolex Championship.  The nine victories was a series record.
In 2011, Pruett won the 24 Hours of Daytona, his fourth overall victory in the event.
In 2012, Pruett was one of the commentators for Speed Channel's coverage of the 24 Hours of Le Mans.
Pruett once again led Ganassi Racing to their 3rd Rolex Series Championship in-a-row with Co-driver Memo Rojas. The team put the No. 01 Telmex BMW Riley on the podium for 9 out of 14 races, top five for 10 out of 14 races with only 2 wins on the season, besting 2nd place Ryan Dalziel by 12 points. This year's results mark Ganassi's 4th title in 5 years, and Pruett's 5th Rolex title.
In 2013 Pruett opened on a strong note, winning the 51st Rolex 24 at Daytona with co-drivers Memo Rojas, Juan Pablo Montoya, and Charlie Kimball. 2013 marks his fifth win at the annual endurance race, tying the legendary Hurley Haywood for most victories in the grueling twice around the clock race.  Despite some serious set-backs during the 2013 season, including accruing 0 points at Detroit, the Championship came down to the last race, with the 01 Ganassi Team taking the Team Title, but Jordan Taylor and Max Angelelli taking the Driver's Title under Wayne Taylor Racing/Velocity Worldwide, with Pruett and Rojas taking 2nd place in the Driver's Standings.
In 2014, Pruett competed in the Tudor United SportsCar Championship for a full season with longtime co-driver Memo Rojas in the Prototype Class.
In 2015 Joey Hand joined Pruett in the 01 for the full season.  The team saw some very disappointing results early in the year due to the aging Riley chassis being outclassed by the Corvette Daytona Prototype.  However, despite not having won a race until late in the season, the 01 had remained consistent enough to be in the championship battle by the last race of the season Petit Le Mans.  By the end of the rain-shortened race only 8 points separated the top 4 teams with CGR taking the top spot.
Pruett departed CGR in 2016 and joined with Paul Gentilozzi, who fielded a Lexus RC F GT3 in the WeatherTech SportsCar Championship. The team was not ready for competition until sometime after the 12 Hours of Sebring. He later announced that he would be driving for Action Express Racing part-time for the season.
On January 5, 2018, Pruett announced his retirement after 50 years in racing, following the 2018 Rolex 24 at Daytona.
Scott Pruett