After moving through the youth ranks of Serie A side Genoa, Ledesma joined Queens Park Rangers on a season-long loan in June 2008.
Ledesma made a bright start to his career in English football, highlighted by a hat-trick at home to Carlisle in the second round of the League Cup, this coming days after his first and what turned out to be only league goal for QPR in a 2–0 win over Doncaster Rovers.
After only a few games at Loftus Road, he had made a good impression on many Queens Park Rangers fans and a limited edition T-shirt was made in his honour.
On 2 February 2009 he left QPR by mutual consent to join Serie B side Salernitana in a half-season loan move.

In July 2009 he went to Novara Calcio, on loan from Genoa, with option to sign him in a co-ownership deal.
Although he won promotion to Serie B with Novara, in June 2010, the club decided to send him back to Genoa.
Ledesma subsequently signed for newly promoted Serie B club, F.C. Crotone, in a co-ownership deal, however, after only half of the season, he returned to Genoa and was released in January 2011.

Following his release by Genoa, Ledesma was offered a trial with Brighton and Hove Albion where, despite scoring on his debut for the reserves, he was not offered a permanent deal.
While playing for Brighton reserves, Ledesma was spotted by Walsall, where he successfully completed a trial, and contracted himself to Walsall until the end of the 2010–11 season.
Ledesma scored one goal in aiding Walsall's successful survival against relegation, before returning to Argentina to re-join boyhood club Defensa y Justicia.
Ledesma returned to England in 2012 and, in March, again signed a contract with Walsall for the remainder of the 2011–12 season.
After moving through the youth ranks of Serie A side Genoa, Ledesma joined Queens Park Rangers on a season-long loan in June 2008. Ledesma made a bright start to his career in English football, highlighted by a hat-trick at home to Carlisle in the second round of the League Cup, this coming days after his first and what turned out to be only league goal for QPR in a 2–0 win over Doncaster Rovers. After only a few games at Loftus Road, he had made a good impression on many Queens Park Rangers fans and a limited edition T-shirt was made in his honour. On 2 February 2009 he left QPR by mutual consent to join Serie B side Salernitana in a half-season loan move.
In July 2009 he went to Novara Calcio, on loan from Genoa, with option to sign him in a co-ownership deal. Although he won promotion to Serie B with Novara, in June 2010, the club decided to send him back to Genoa. Ledesma subsequently signed for newly promoted Serie B club, F.C. Crotone, in a co-ownership deal, however, after only half of the season, he returned to Genoa and was released in January 2011.
Following his release by Genoa, Ledesma was offered a trial with Brighton and Hove Albion where, despite scoring on his debut for the reserves, he was not offered a permanent deal. While playing for Brighton reserves, Ledesma was spotted by Walsall, where he successfully completed a trial, and contracted himself to Walsall until the end of the 2010–11 season. Ledesma scored one goal in aiding Walsall's successful survival against relegation, before returning to Argentina to re-join boyhood club Defensa y Justicia. Ledesma returned to England in 2012 and, in March, again signed a contract with Walsall for the remainder of the 2011–12 season.
Emmanuel Ledesma