On December 1, 1981, Inex-Adria Aviopromet Flight 1308, MD-81 (YU-ANA), crashed into Corsica's Mt. San Pietro during a holding pattern for landing at Campo dell'Oro Airport, Ajaccio, France.
All 180 passengers and crew were killed.
This was the first-ever fatal incident involving the MD-80 series and also the deadliest.

On August 16, 1987, Northwest Airlines Flight 255, MD-82, crashed shortly after takeoff from Detroit Metropolitan Wayne County Airport due to the flight crew's failure to use the taxi checklist to ensure that flaps and slats were extended for takeoff, according to the NTSB.
All crew and passengers were killed, with the exception of a four-year-old girl, Cecelia Cichan.
Two people on the ground were also killed.

On June 12, 1988, Austral Líneas Aéreas Flight 46, MD-81 N1003G, crashed short of the runway at Libertador General José de San Martín Airport, in Posadas, Misiones.
All 22 passengers and crew were killed.

On December 27, 1991, SAS Flight 751, MD-81 OY-KHO "Dana Viking", crash-landed at Gottröra, Sweden.
In the initial climb, both engines ingested ice broken loose from the wings (although they had been properly deiced before departure).
The ice damaged the compressor blades causing compressor stall.
The stall further caused repeated engine surges that finally destroyed both engines, leaving the aircraft with no thrust.
The aircraft landed in a snowy field and broke into three parts.
No fire occurred, and all aboard survived.

On November 13, 1993, China Northern Airlines Flight 6901, MD-82 B-2141, crashed before landing at Ürümqi Diwopu International Airport in Xinjiang, China, killing twelve of the 102 passengers and crew on board.

On July 6, 1996, Delta Air Lines Flight 1288, an MD-88, attempting to take off from Pensacola Regional Airport experienced an uncontained, catastrophic turbine engine failure that caused debris from the front compressor hub of the number one left engine to penetrate the left aft fuselage.
The penetrating debris left two passengers dead and two severely injured; all were from the same family.
The pilot aborted takeoff, and the airplane stopped on the runway.

On June 1, 1999, American Airlines Flight 1420, an MD-82, attempting to land in severe weather conditions at Little Rock Airport overshot the runway and crashed into the banks of the Arkansas River.
Eleven people, including the captain, died.

On January 31, 2000, Alaska Airlines Flight 261, an MD-83, crashed in the Pacific Ocean, due to loss of horizontal stabilizer control.
All 88 passengers and crew on board were killed.
Following the crash, an improperly maintained Acme nut and jackscrew recovered from the aircraft were found to be excessively worn.
An airworthiness directive (AD) was issued by the FAA requiring more frequent inspections and lubrication of the jackscrew assembly.

On October 8, 2001, Scandinavian Airlines Flight 686, MD-87 SE-DMA collided with a small Cessna jet during take-off at Linate Airport, Milan, Italy.
The Linate Airport disaster left 118 people dead.
The cause of the accident was a misunderstanding between air traffic controllers and the Cessna jet, complicated by inoperative ground movement radar at the time of the accident.
The SAS crew had no role in causing the accident.

On May 7, 2002, China Northern Airlines Flight 6136, an MD-82, from Beijing to Dalian, crashed into Dalian Bay near Dalian after the pilot reported "fire on board".
All 112 people on board were killed.
Investigators determined that the fire had been set by a suicidal passenger.

On November 30, 2004, Lion Air Flight 583, MD-82, crashed on landing at Adi Sumarmo Airport in Surakarta, Indonesia and overran the end of the runway, causing the death of 25 passengers and crew.

On August 16, 2005, West Caribbean Airways Flight 708, MD-82, crashed in a mountainous region in northwest Venezuela killing all 152 passengers and eight crew.

On March 4, 2006, Lion Air Flight 8987, MD-82, after landing at Juanda International Airport, applied reverse thrust, although the reversers were stated to be out of order.
This caused the aircraft
On December 1, 1981, Inex-Adria Aviopromet Flight 1308, MD-81 (YU-ANA), crashed into Corsica's Mt. San Pietro during a holding pattern for landing at Campo dell'Oro Airport, Ajaccio, France. All 180 passengers and crew were killed. This was the first-ever fatal incident involving the MD-80 series and also the deadliest.
On August 16, 1987, Northwest Airlines Flight 255, MD-82, crashed shortly after takeoff from Detroit Metropolitan Wayne County Airport due to the flight crew's failure to use the taxi checklist to ensure that flaps and slats were extended for takeoff, according to the NTSB. All crew and passengers were killed, with the exception of a four-year-old girl, Cecelia Cichan. Two people on the ground were also killed.
On June 12, 1988, Austral Líneas Aéreas Flight 46, MD-81 N1003G, crashed short of the runway at Libertador General José de San Martín Airport, in Posadas, Misiones. All 22 passengers and crew were killed.
On December 27, 1991, SAS Flight 751, MD-81 OY-KHO "Dana Viking", crash-landed at Gottröra, Sweden. In the initial climb, both engines ingested ice broken loose from the wings (although they had been properly deiced before departure). The ice damaged the compressor blades causing compressor stall. The stall further caused repeated engine surges that finally destroyed both engines, leaving the aircraft with no thrust. The aircraft landed in a snowy field and broke into three parts. No fire occurred, and all aboard survived.
On November 13, 1993, China Northern Airlines Flight 6901, MD-82 B-2141, crashed before landing at Ürümqi Diwopu International Airport in Xinjiang, China, killing twelve of the 102 passengers and crew on board.
On July 6, 1996, Delta Air Lines Flight 1288, an MD-88, attempting to take off from Pensacola Regional Airport experienced an uncontained, catastrophic turbine engine failure that caused debris from the front compressor hub of the number one left engine to penetrate the left aft fuselage. The penetrating debris left two passengers dead and two severely injured; all were from the same family. The pilot aborted takeoff, and the airplane stopped on the runway.
On June 1, 1999, American Airlines Flight 1420, an MD-82, attempting to land in severe weather conditions at Little Rock Airport overshot the runway and crashed into the banks of the Arkansas River. Eleven people, including the captain, died.
On January 31, 2000, Alaska Airlines Flight 261, an MD-83, crashed in the Pacific Ocean, due to loss of horizontal stabilizer control. All 88 passengers and crew on board were killed. Following the crash, an improperly maintained Acme nut and jackscrew recovered from the aircraft were found to be excessively worn. An airworthiness directive (AD) was issued by the FAA requiring more frequent inspections and lubrication of the jackscrew assembly.
On October 8, 2001, Scandinavian Airlines Flight 686, MD-87 SE-DMA collided with a small Cessna jet during take-off at Linate Airport, Milan, Italy. The Linate Airport disaster left 118 people dead. The cause of the accident was a misunderstanding between air traffic controllers and the Cessna jet, complicated by inoperative ground movement radar at the time of the accident. The SAS crew had no role in causing the accident.
On May 7, 2002, China Northern Airlines Flight 6136, an MD-82, from Beijing to Dalian, crashed into Dalian Bay near Dalian after the pilot reported "fire on board". All 112 people on board were killed. Investigators determined that the fire had been set by a suicidal passenger.
On November 30, 2004, Lion Air Flight 583, MD-82, crashed on landing at Adi Sumarmo Airport in Surakarta, Indonesia and overran the end of the runway, causing the death of 25 passengers and crew.
On August 16, 2005, West Caribbean Airways Flight 708, MD-82, crashed in a mountainous region in northwest Venezuela killing all 152 passengers and eight crew.
On March 4, 2006, Lion Air Flight 8987, MD-82, after landing at Juanda International Airport, applied reverse thrust, although the reversers were stated to be out of order. This caused the aircraft
McDonnell Douglas MD-80