The hospital has its origins in the Down County Infirmary which opened in Saul Street in October 1767.
It moved to the site of the old horse barracks in Barrack Lane, now Fountain Street, in 1774.

A new infirmary was established at Pound Lane in 1834 but by the late 1970s it was already becoming apparent that it was incapable of further expansion.
The old infirmary on Pound Lane closed in June 2009 and was acquired by a developer in November 2014.

A modern hospital, which was designed by Scott Wilson Group and built on Ardglass Road at a cost of £64 million, opened in June 2009.
The hospital has its origins in the Down County Infirmary which opened in Saul Street in October 1767. It moved to the site of the old horse barracks in Barrack Lane, now Fountain Street, in 1774.
A new infirmary was established at Pound Lane in 1834 but by the late 1970s it was already becoming apparent that it was incapable of further expansion. The old infirmary on Pound Lane closed in June 2009 and was acquired by a developer in November 2014.
A modern hospital, which was designed by Scott Wilson Group and built on Ardglass Road at a cost of £64 million, opened in June 2009.
Downe Hospital