Megabats are the reservoirs of several viruses that can affect humans and cause disease.
They can carry filoviruses, including the Ebola virus (EBOV) and Marburgvirus.
The presence of Marburgvirus, which causes Marburg virus disease, has been confirmed in one species, the Egyptian fruit bat.
The disease is rare, but the fatality rate of an outbreak can reach up to 88%.
The virus was first recognized after simultaneous outbreaks in the German cities of Marburg and Frankfurt as well as Belgrade, Serbia in 1967 where 31 people became ill and seven died.
The outbreak was traced to laboratory work with vervet monkeys from Uganda.
The virus can pass from a bat host to a human (who has usually spent a prolonged period in a mine or cave where Egyptian fruit bats live); from there, it can spread person-to-person through contact with infected bodily fluids, including blood and semen.
The United States Centers for Disease Control and Prevention lists a total of 601 confirmed cases of Marburg virus disease from 1967 to 2014, of which 373 people died (62% overall mortality).

Species that have tested positive for the presence of EBOV include Franquet's epauletted fruit bat (Epomops franqueti), the hammer-headed fruit bat, and the little collared fruit bat.
Additionally, antibodies against EBOV have been found in the straw-coloured fruit bat, Gambian epauletted fruit bat (Epomophorus gambianus), Peters's dwarf epauletted fruit bat (Micropteropus pusillus), Veldkamp's dwarf epauletted fruit bat (Nanonycteris veldkampii), Leschenault's rousette, and the Egyptian fruit bat.
Much of how humans contract the Ebola virus is unknown.
Scientists hypothesize that humans initially become infected through contact with an infected animal such as a megabat or non-human primate.
Megabats are presumed to be a natural reservoir of the Ebola virus, but this has not been firmly established.
Microbats are also being investigated as the reservoir of the virus, with the greater long-fingered bat (Miniopterus inflatus) once found to harbor a fifth of the virus's genome (though not testing positive for the actual virus) in 2019.
Due to the likely association between Ebola infection and "hunting, butchering and processing meat from infected animals", several West African countries banned bushmeat (including megabats) or issued warnings about it during the 2013–2016 epidemic; many bans have since been lifted.

Other megabats implicated as disease reservoirs are primarily Pteropus species.
Notably, flying foxes can transmit Australian bat lyssavirus, which, along with the rabies virus, causes rabies.
Australian bat lyssavirus was first identified in 1996; it is very rarely transmitted to humans.
Transmission occurs from the bite or scratch of an infected animal but can also occur from getting the infected animal's saliva in a mucous membrane or an open wound.
Exposure to flying fox blood, urine, or feces cannot cause infections of Australian bat lyssavirus.
Since 1994, there have been three records of people becoming infected with it in Queensland—each case was fatal.

Flying foxes are also reservoirs of henipaviruses such as Hendra virus and Nipah virus.
Hendra virus was first identified in 1994; it rarely occurs in humans.
From 1994 to 2013, there have been seven reported cases of Hendra virus affecting people, four of which were fatal.
The hypothesized primary route of human infection is via contact with horses that have come into contact with flying fox urine.
There are no documented instances of direct transmission between flying foxes and humans.
As of 2012, there is a vaccine available for horses to decrease the likelihood of infection and transmission.

Nipah virus was first identified in 1998 in Malaysia.
Since 1998, there have been several Nipah outbreaks in Malaysia, Singapore, India, and Bangladesh, resulting in over 100 casualties.
A 2018 outbreak in Kerala, India resulted in 19 humans becoming infected—17 died.
The overall fatality rate is 40–75%.
Humans can contract Nipah virus from direct contact with flying foxes or their fluids, through exposure t
Megabats are the reservoirs of several viruses that can affect humans and cause disease. They can carry filoviruses, including the Ebola virus (EBOV) and Marburgvirus. The presence of Marburgvirus, which causes Marburg virus disease, has been confirmed in one species, the Egyptian fruit bat. The disease is rare, but the fatality rate of an outbreak can reach up to 88%. The virus was first recognized after simultaneous outbreaks in the German cities of Marburg and Frankfurt as well as Belgrade, Serbia in 1967 where 31 people became ill and seven died. The outbreak was traced to laboratory work with vervet monkeys from Uganda. The virus can pass from a bat host to a human (who has usually spent a prolonged period in a mine or cave where Egyptian fruit bats live); from there, it can spread person-to-person through contact with infected bodily fluids, including blood and semen. The United States Centers for Disease Control and Prevention lists a total of 601 confirmed cases of Marburg virus disease from 1967 to 2014, of which 373 people died (62% overall mortality).
Species that have tested positive for the presence of EBOV include Franquet's epauletted fruit bat (Epomops franqueti), the hammer-headed fruit bat, and the little collared fruit bat. Additionally, antibodies against EBOV have been found in the straw-coloured fruit bat, Gambian epauletted fruit bat (Epomophorus gambianus), Peters's dwarf epauletted fruit bat (Micropteropus pusillus), Veldkamp's dwarf epauletted fruit bat (Nanonycteris veldkampii), Leschenault's rousette, and the Egyptian fruit bat. Much of how humans contract the Ebola virus is unknown. Scientists hypothesize that humans initially become infected through contact with an infected animal such as a megabat or non-human primate. Megabats are presumed to be a natural reservoir of the Ebola virus, but this has not been firmly established. Microbats are also being investigated as the reservoir of the virus, with the greater long-fingered bat (Miniopterus inflatus) once found to harbor a fifth of the virus's genome (though not testing positive for the actual virus) in 2019. Due to the likely association between Ebola infection and "hunting, butchering and processing meat from infected animals", several West African countries banned bushmeat (including megabats) or issued warnings about it during the 2013–2016 epidemic; many bans have since been lifted.
Other megabats implicated as disease reservoirs are primarily Pteropus species. Notably, flying foxes can transmit Australian bat lyssavirus, which, along with the rabies virus, causes rabies. Australian bat lyssavirus was first identified in 1996; it is very rarely transmitted to humans. Transmission occurs from the bite or scratch of an infected animal but can also occur from getting the infected animal's saliva in a mucous membrane or an open wound. Exposure to flying fox blood, urine, or feces cannot cause infections of Australian bat lyssavirus. Since 1994, there have been three records of people becoming infected with it in Queensland—each case was fatal.
Flying foxes are also reservoirs of henipaviruses such as Hendra virus and Nipah virus. Hendra virus was first identified in 1994; it rarely occurs in humans. From 1994 to 2013, there have been seven reported cases of Hendra virus affecting people, four of which were fatal. The hypothesized primary route of human infection is via contact with horses that have come into contact with flying fox urine. There are no documented instances of direct transmission between flying foxes and humans. As of 2012, there is a vaccine available for horses to decrease the likelihood of infection and transmission.
Nipah virus was first identified in 1998 in Malaysia. Since 1998, there have been several Nipah outbreaks in Malaysia, Singapore, India, and Bangladesh, resulting in over 100 casualties. A 2018 outbreak in Kerala, India resulted in 19 humans becoming infected—17 died. The overall fatality rate is 40–75%. Humans can contract Nipah virus from direct contact with flying foxes or their fluids, through exposure t
Megabat