The club was founded in 1924, one of the oldest Macedonian football clubs.

In 1973, during a football match between FK Osogovo and FK FAS 11 Oktomvri from Skopje, the 23-year-old Nikola Mantov – one of the best players of FK Osogovo at the time – collapsed on the field and died.
In his honor, the home-ground of FK Osogovo is named Nikola Mantov Stadium.
The stadium has a capacity of approximately 5,000 spectators.

FK Osogovo has also retired the number 7 shirt in honor of Nikola Mantov.

In the first season of the Macedonian First Football League in 1992–93 Osogovo finished at eighth place; next season they finished at position nine.
The highest place in Osogovo history in Macedonian First Football League was in the 1994-95 season, when the team finished at sixth position.
Next season (1995–96) they finished at 14th place and were relegated to the Macedonian Second Football League.
In the next few years, the team was relegated to the lowest division in Macedonian football (Macedonian Third Football League).
From the 2004–05 to 2010-2011 seasons, Osogovo won the Macedonian Third Football League (East) five times, but played only once in the Macedonian Second Football League, in the 2011–12 season.
In this season they finished at 14th place and were relegated to Macedonian Third Football League (East).
In the last five seasons Osogovo appeared in the Macedonian Third Football League (East) without any success.
But in season 2016-17 FK Osogovo finished at 3rd place and promoted to Macedonian Second Football league(East).
The club was founded in 1924, one of the oldest Macedonian football clubs.
In 1973, during a football match between FK Osogovo and FK FAS 11 Oktomvri from Skopje, the 23-year-old Nikola Mantov – one of the best players of FK Osogovo at the time – collapsed on the field and died. In his honor, the home-ground of FK Osogovo is named Nikola Mantov Stadium. The stadium has a capacity of approximately 5,000 spectators.
FK Osogovo has also retired the number 7 shirt in honor of Nikola Mantov.
In the first season of the Macedonian First Football League in 1992–93 Osogovo finished at eighth place; next season they finished at position nine. The highest place in Osogovo history in Macedonian First Football League was in the 1994-95 season, when the team finished at sixth position. Next season (1995–96) they finished at 14th place and were relegated to the Macedonian Second Football League. In the next few years, the team was relegated to the lowest division in Macedonian football (Macedonian Third Football League). From the 2004–05 to 2010-2011 seasons, Osogovo won the Macedonian Third Football League (East) five times, but played only once in the Macedonian Second Football League, in the 2011–12 season. In this season they finished at 14th place and were relegated to Macedonian Third Football League (East). In the last five seasons Osogovo appeared in the Macedonian Third Football League (East) without any success. But in season 2016-17 FK Osogovo finished at 3rd place and promoted to Macedonian Second Football league(East).
FK Osogovo