Oudin began her 2010 season at the Moorilla Hobart International.
She lost in the first round to Sara Errani.
At the Australian Open, Oudin was defeated in the first round by Alla Kudryavtseva.

During the Fed Cup tie versus France, Oudin won both of her rubbers over Pauline Parmentier and Julie Coin.
The USA won the tie over France 4-1 to move on to the semifinal round.
Oudin reached her first semifinal of a WTA Tour event at the Open GDF Suez in Paris.
She fell in three sets to top seed Elena Dementieva, in a rematch of their 2009 US Open second round match.
Seeded second at the Cellular South Cup, Oudin made it to the quarterfinal round where she lost to qualifier and eventual finalist Sofia Arvidsson.
In March, Oudin played at the BNP Paribas Open; she was defeated in the first round by Roberta Vinci.
At the Sony Ericsson Open, Oudin lost in the second round to eleventh seed Vera Zvonareva.
Seeded eighth at the MPS Group Championships, Oudin reached the quarterfinal round where she was defeated by fourth seed Elena Vesnina.
Oudin began her 2010 season at the Moorilla Hobart International. She lost in the first round to Sara Errani. At the Australian Open, Oudin was defeated in the first round by Alla Kudryavtseva.
During the Fed Cup tie versus France, Oudin won both of her rubbers over Pauline Parmentier and Julie Coin. The USA won the tie over France 4-1 to move on to the semifinal round. Oudin reached her first semifinal of a WTA Tour event at the Open GDF Suez in Paris. She fell in three sets to top seed Elena Dementieva, in a rematch of their 2009 US Open second round match. Seeded second at the Cellular South Cup, Oudin made it to the quarterfinal round where she lost to qualifier and eventual finalist Sofia Arvidsson. In March, Oudin played at the BNP Paribas Open; she was defeated in the first round by Roberta Vinci. At the Sony Ericsson Open, Oudin lost in the second round to eleventh seed Vera Zvonareva. Seeded eighth at the MPS Group Championships, Oudin reached the quarterfinal round where she was defeated by fourth seed Elena Vesnina.
Melanie Oudin