Two major freeways—Interstate 15 and Interstate 515 (including US 93 and US 95)—cross in downtown Las Vegas.
I-15 connects Las Vegas to Los Angeles and San Diego, and heads northeast to Salt Lake City and beyond.
Interstate 11 will eventually serve the connection from Nogales, Arizona to the Reno and Sparks vicinity of either Fernley or at the Reno Spaghetti Bowl in Reno when completed.
I-515 goes southeast to Henderson, beyond which Interstate 11 bypasses Boulder City and U.S. Route 93 continues past the Mike O'Callaghan–Pat Tillman Memorial Bridge over the Colorado River towards Phoenix, Arizona.
US 95 connects the city to northwestern Nevada, including Carson City (the state capitol) and Reno.
US 93 splits from I-15 northeast of Las Vegas and goes north through the northeastern part of the state, serving Ely and Wells and US 95 heads south from I-11 and US 93 in Boulder City through far southeastern California.
A three-quarters of the Las Vegas Beltway has been built, consisting of Interstate 215 on the south and Clark County 215 on the west and north.
Other radial routes include SR 160 to Pahrump and SR 147 and SR 564 (former SR 146) to Lake Mead.

With the notable exceptions of Las Vegas Boulevard, Boulder Highway and Tonopah Highway (better known as the northern part of Rancho Drive), the majority of surface streets outside downtown Las Vegas are laid out along Public Land Survey System section lines.
Many are maintained, in part, by the Nevada Department of Transportation (NDOT) as state highways.

East-west roads, north to south
 Las Vegas Beltway (CC 215)
Ann Road
 Craig Road (SR 573)
 Cheyenne Avenue (SR 574)
Carey Avenue
 Lake Mead Boulevard (SR 147)
 Washington Avenue (SR 578)
 Summerlin Parkway (SR 613) – on the west side past Rainbow Boulevard
 Bonanza Road (SR 579)
 US 95 – on the west side of the valley
 – Interstate 515, US 93 and US 95 on the east side of the valley
 Charleston Boulevard (SR 159)
Sahara Avenue (former SR 589)
Desert Inn Road
Spring Mountain Road (former SR 591)
 Flamingo Road (SR 592)
 Tropicana Avenue (SR 593)
 Russell Road (SR 594)
 Sunset Road (SR 562)
Warm Springs Road
 Blue Diamond Road (SR 160)
 Las Vegas Beltway (I-215)
 Lake Mead Parkway (formerly Lake Mead Drive) (SR 564)
Horizon Ridge Parkway
 Saint Rose Parkway (formerly Lake Mead Drive) (SR 146)
North-south roads, west to east
 Las Vegas Beltway (CC 215)
Durango Drive
Buffalo Drive
 Rainbow Boulevard (SR 595)
 Jones Boulevard (SR 596)
Decatur Boulevard
Valley View Boulevard
Dean Martin Drive (formerly Industrial Road)
 Interstate 15
 Las Vegas Boulevard (SR 604)
 Rancho Drive (SR 599)
 Paradise Road (SR 605)
Maryland Parkway
 Eastern Avenue (SR 607)
Pecos Road
 – Interstate 515, US 93 and US 95 south of Charleston Boulevard
 Lamb Boulevard (SR 610)
 Nellis Boulevard (SR 612)
Major Freeways
 Interstate 11
 Interstate 15
 Las Vegas Beltway (I-215)
 Interstate 515
 Las Vegas Beltway (CC 215)
 US 95
 Summerlin Parkway (SR 613)
Two major freeways—Interstate 15 and Interstate 515 (including US 93 and US 95)—cross in downtown Las Vegas. I-15 connects Las Vegas to Los Angeles and San Diego, and heads northeast to Salt Lake City and beyond. Interstate 11 will eventually serve the connection from Nogales, Arizona to the Reno and Sparks vicinity of either Fernley or at the Reno Spaghetti Bowl in Reno when completed. I-515 goes southeast to Henderson, beyond which Interstate 11 bypasses Boulder City and U.S. Route 93 continues past the Mike O'Callaghan–Pat Tillman Memorial Bridge over the Colorado River towards Phoenix, Arizona. US 95 connects the city to northwestern Nevada, including Carson City (the state capitol) and Reno. US 93 splits from I-15 northeast of Las Vegas and goes north through the northeastern part of the state, serving Ely and Wells and US 95 heads south from I-11 and US 93 in Boulder City through far southeastern California. A three-quarters of the Las Vegas Beltway has been built, consisting of Interstate 215 on the south and Clark County 215 on the west and north. Other radial routes include SR 160 to Pahrump and SR 147 and SR 564 (former SR 146) to Lake Mead.
With the notable exceptions of Las Vegas Boulevard, Boulder Highway and Tonopah Highway (better known as the northern part of Rancho Drive), the majority of surface streets outside downtown Las Vegas are laid out along Public Land Survey System section lines. Many are maintained, in part, by the Nevada Department of Transportation (NDOT) as state highways.
East-west roads, north to south
 Las Vegas Beltway (CC 215)
Ann Road
 Craig Road (SR 573)
 Cheyenne Avenue (SR 574)
Carey Avenue
 Lake Mead Boulevard (SR 147)
 Washington Avenue (SR 578)
 Summerlin Parkway (SR 613) – on the west side past Rainbow Boulevard
 Bonanza Road (SR 579)
 US 95 – on the west side of the valley
 – Interstate 515, US 93 and US 95 on the east side of the valley
 Charleston Boulevard (SR 159)
Sahara Avenue (former SR 589)
Desert Inn Road
Spring Mountain Road (former SR 591)
 Flamingo Road (SR 592)
 Tropicana Avenue (SR 593)
 Russell Road (SR 594)
 Sunset Road (SR 562)
Warm Springs Road
 Blue Diamond Road (SR 160)
 Las Vegas Beltway (I-215)
 Lake Mead Parkway (formerly Lake Mead Drive) (SR 564)
Horizon Ridge Parkway
 Saint Rose Parkway (formerly Lake Mead Drive) (SR 146)
North-south roads, west to east
 Las Vegas Beltway (CC 215)
Durango Drive
Buffalo Drive
 Rainbow Boulevard (SR 595)
 Jones Boulevard (SR 596)
Decatur Boulevard
Valley View Boulevard
Dean Martin Drive (formerly Industrial Road)
 Interstate 15
 Las Vegas Boulevard (SR 604)
 Rancho Drive (SR 599)
 Paradise Road (SR 605)
Maryland Parkway
 Eastern Avenue (SR 607)
Pecos Road
 – Interstate 515, US 93 and US 95 south of Charleston Boulevard
 Lamb Boulevard (SR 610)
 Nellis Boulevard (SR 612)
Major Freeways
 Interstate 11
 Interstate 15
 Las Vegas Beltway (I-215)
 Interstate 515
 Las Vegas Beltway (CC 215)
 US 95
 Summerlin Parkway (SR 613)
Las Vegas Valley