The North-South Expressway is the main highway that runs across the more developed western Peninsular Malaysia; the expressway forms part of Asian Highway 2, as it is connected to Thailand's Phet Kasem Road at its northern end and the Singapore Causeway at its southern end.
This expressway runs through Seberang Perai, thus connecting major areas, such as Butterworth, Seberang Jaya, Perai, Juru, Batu Kawan and Nibong Tebal, with other cities and towns along western Peninsular Malaysia, southern Thailand and Singapore.

Other major roads and expressways within Seberang Perai include the Butterworth Outer Ring Road (BORR) and the Butterworth–Seberang Jaya Toll Road.
The BORR was constructed in the 2000s to alleviate traffic congestion along the North–South Expressway, providing drivers from Butterworth with an alternative route to Perai to the south.
The Prai River Bridge was also built for this purpose, traversing the Perai River that separates Butterworth and Perai.
In addition, the BORR is linked to the Butterworth–Seberang Jaya Toll Road, which was completed in 2007.

Aside from roads and expressways, rail transportation has historically played a vital role in Seberang Perai's economy.
The first railway tracks were laid in the 1900s, connecting the area with the rest of Malaya for the first time, and facilitating the transportation of agricultural and mining commodities for export via the Port of Penang.
Today, about 34.9 km (21.7 mi) of rail track stretches within Seberang Perai as part of the Malayan Railway's West Coast Route.
Out of the six train stations in Seberang Perai, the two major stations are in Butterworth and Bukit Mertajam, with the former offering services by both the Malayan Railway and the State Railway of Thailand; the Butterworth rail station is also one of the major stops of the Eastern and Oriental Express between Bangkok and Singapore.
Domestically, the Malayan Railway runs the inter-state Electric Train Service along much of its West Coast Route, allowing train commuters from Penang to travel to Kuala Lumpur in as little as four hours.

The two bridges that connect Seberang Perai with Penang Island are the Penang Bridge and the Second Penang Bridge.
The Penang Bridge links Perai and Gelugor, a southern suburb of Penang's capital city, George Town, and was completed in 1985.
At the time of its opening, the bridge was the longest in Southeast Asia.
In 2013, it was superseded by the 24 km (15 mi)-long Second Penang Bridge to the south, which runs between Batu Kawan and Batu Maung near the southeastern tip of Penang Island.

A major transportation hub, Penang Sentral, is being constructed in Butterworth, and the first phase of the project, which consists of an inter-city bus terminal, is slated for completion in 2017.
Penang Sentral is strategically located next to the Sultan Abdul Halim Ferry Terminal and the Butterworth rail station.
Overall, there are eight phases of the Penang Sentral project, which aims to integrate all bus, rail and ferry services under a single mixed complex that will also incorporate commercial, residential and retail elements, akin to Kuala Lumpur Sentral.
The North-South Expressway is the main highway that runs across the more developed western Peninsular Malaysia; the expressway forms part of Asian Highway 2, as it is connected to Thailand's Phet Kasem Road at its northern end and the Singapore Causeway at its southern end. This expressway runs through Seberang Perai, thus connecting major areas, such as Butterworth, Seberang Jaya, Perai, Juru, Batu Kawan and Nibong Tebal, with other cities and towns along western Peninsular Malaysia, southern Thailand and Singapore.
Other major roads and expressways within Seberang Perai include the Butterworth Outer Ring Road (BORR) and the Butterworth–Seberang Jaya Toll Road. The BORR was constructed in the 2000s to alleviate traffic congestion along the North–South Expressway, providing drivers from Butterworth with an alternative route to Perai to the south. The Prai River Bridge was also built for this purpose, traversing the Perai River that separates Butterworth and Perai. In addition, the BORR is linked to the Butterworth–Seberang Jaya Toll Road, which was completed in 2007.
Aside from roads and expressways, rail transportation has historically played a vital role in Seberang Perai's economy. The first railway tracks were laid in the 1900s, connecting the area with the rest of Malaya for the first time, and facilitating the transportation of agricultural and mining commodities for export via the Port of Penang. Today, about 34.9 km (21.7 mi) of rail track stretches within Seberang Perai as part of the Malayan Railway's West Coast Route. Out of the six train stations in Seberang Perai, the two major stations are in Butterworth and Bukit Mertajam, with the former offering services by both the Malayan Railway and the State Railway of Thailand; the Butterworth rail station is also one of the major stops of the Eastern and Oriental Express between Bangkok and Singapore. Domestically, the Malayan Railway runs the inter-state Electric Train Service along much of its West Coast Route, allowing train commuters from Penang to travel to Kuala Lumpur in as little as four hours.
The two bridges that connect Seberang Perai with Penang Island are the Penang Bridge and the Second Penang Bridge. The Penang Bridge links Perai and Gelugor, a southern suburb of Penang's capital city, George Town, and was completed in 1985. At the time of its opening, the bridge was the longest in Southeast Asia. In 2013, it was superseded by the 24 km (15 mi)-long Second Penang Bridge to the south, which runs between Batu Kawan and Batu Maung near the southeastern tip of Penang Island.
A major transportation hub, Penang Sentral, is being constructed in Butterworth, and the first phase of the project, which consists of an inter-city bus terminal, is slated for completion in 2017. Penang Sentral is strategically located next to the Sultan Abdul Halim Ferry Terminal and the Butterworth rail station. Overall, there are eight phases of the Penang Sentral project, which aims to integrate all bus, rail and ferry services under a single mixed complex that will also incorporate commercial, residential and retail elements, akin to Kuala Lumpur Sentral.
Seberang Perai