On 5 August 1940, the first production Avro Manchester, L7276, was delivered to RAF Boscombe Down in advance of service acceptance trials.
In November 1940, the Manchester officially entered service with the newly reformed No.
207 Squadron of RAF Bomber Command.
The type passed all acceptance tests by 21 December 1940, and 207 Squadron had at least 80 Manchesters on strength by the end of 1940.
The Manchester's first operational mission was conducted on 24–25 February 1941 in a raid on the French port of Brest.
On 13 March 1941, L7319 became the first Manchester to be shot down by enemy fire.

On 13 April 1941, all Manchesters were temporarily grounded due to a higher than expected number of engine bearing failures; on 16 June 1941, a second grounding of the type was ordered due to continuing engine troubles.
The unservicability of the Vulture engine forced squadrons to make use of obsolete bombers such as the Handley Page Hampden in its place.
Upon the restart of operations in August 1941, additional issues with the aircraft were encountered; the problems included excessive tail flutter, hydraulic failures, and faulty propeller feathering controls.
Production of the Manchester was halted in November 1941, by which point a total of 209 aircraft had entered service with the RAF.
A total of eight bomber squadrons were equipped with the type, it also served in two further squadrons and  also saw use by RAF Coastal Command.

While modifications were made by Avro to address some of the technical issues experienced, unit strength suffered and Bomber Command was frequently unable to raise significant numbers of aircraft to participate in large scale bombing missions; on 7 November 1941, all of the RAFs serviceable bombers had been dispatched to bomb Berlin, out of a force of over 400 bombers, only 15 were Manchesters.
On 3 March 1942, out of a force of nearly 200 bombers sent against a Renault factory near Paris, 25 were Manchesters; while during the first 1,000 bomber raid on Cologne on 30 May 1942, 35 Manchesters were amongst the 1,047 bombers sent to attack the city.
Flying Officer Leslie Manser was posthumously awarded the Victoria Cross for his actions while piloting Manchester L7301 of 50 Squadron during the Cologne bombing mission.

The Mk III Manchester (serial number BT308) which first flew on 9 January 1941, was essentially the first Lancaster, featuring a longer wing fitted with four Rolls-Royce Merlins in new unitized, power-egg nacelles – originally developed by Rolls-Royce for the Merlin-powered Beaufighter II – although initially retaining the three fins and twin outboard rudders (the central fin had no movable control surface) of the Manchester I. BT308 received the "Lancaster" name immediately after its first flight.
The second prototype Lancaster DG595 featured the twin, enlarged fins and rudders of the Manchester IA.
Manchester production continued until November of that year but some aircraft that were still in production were instead completed as Lancasters.

The 193 operational Manchesters flew 1,269 sorties with Bomber Command, dropping 1,826 tons (1,657 tonnes) of bombs and lost 78 aircraft in action, flying its last operation against Bremen on 25 June 1942.
A further 45 were non-operational losses of which 30 involved engine failure.
The Manchester was withdrawn from operations in mid-1942 in favour of more capable aircraft.
Its final role in RAF service was as instructional trainers for converting crews to the RAF's new Lancaster bombers; the Manchester and Lancaster shared nearly identical crew positions and fuselages.
The type persisted in use for training purposes into 1943 before being completely retired.
On 5 August 1940, the first production Avro Manchester, L7276, was delivered to RAF Boscombe Down in advance of service acceptance trials. In November 1940, the Manchester officially entered service with the newly reformed No. 207 Squadron of RAF Bomber Command. The type passed all acceptance tests by 21 December 1940, and 207 Squadron had at least 80 Manchesters on strength by the end of 1940. The Manchester's first operational mission was conducted on 24–25 February 1941 in a raid on the French port of Brest. On 13 March 1941, L7319 became the first Manchester to be shot down by enemy fire.
On 13 April 1941, all Manchesters were temporarily grounded due to a higher than expected number of engine bearing failures; on 16 June 1941, a second grounding of the type was ordered due to continuing engine troubles. The unservicability of the Vulture engine forced squadrons to make use of obsolete bombers such as the Handley Page Hampden in its place. Upon the restart of operations in August 1941, additional issues with the aircraft were encountered; the problems included excessive tail flutter, hydraulic failures, and faulty propeller feathering controls. Production of the Manchester was halted in November 1941, by which point a total of 209 aircraft had entered service with the RAF. A total of eight bomber squadrons were equipped with the type, it also served in two further squadrons and  also saw use by RAF Coastal Command.
While modifications were made by Avro to address some of the technical issues experienced, unit strength suffered and Bomber Command was frequently unable to raise significant numbers of aircraft to participate in large scale bombing missions; on 7 November 1941, all of the RAFs serviceable bombers had been dispatched to bomb Berlin, out of a force of over 400 bombers, only 15 were Manchesters. On 3 March 1942, out of a force of nearly 200 bombers sent against a Renault factory near Paris, 25 were Manchesters; while during the first 1,000 bomber raid on Cologne on 30 May 1942, 35 Manchesters were amongst the 1,047 bombers sent to attack the city. Flying Officer Leslie Manser was posthumously awarded the Victoria Cross for his actions while piloting Manchester L7301 of 50 Squadron during the Cologne bombing mission.
The Mk III Manchester (serial number BT308) which first flew on 9 January 1941, was essentially the first Lancaster, featuring a longer wing fitted with four Rolls-Royce Merlins in new unitized, power-egg nacelles – originally developed by Rolls-Royce for the Merlin-powered Beaufighter II – although initially retaining the three fins and twin outboard rudders (the central fin had no movable control surface) of the Manchester I. BT308 received the "Lancaster" name immediately after its first flight. The second prototype Lancaster DG595 featured the twin, enlarged fins and rudders of the Manchester IA. Manchester production continued until November of that year but some aircraft that were still in production were instead completed as Lancasters.
The 193 operational Manchesters flew 1,269 sorties with Bomber Command, dropping 1,826 tons (1,657 tonnes) of bombs and lost 78 aircraft in action, flying its last operation against Bremen on 25 June 1942. A further 45 were non-operational losses of which 30 involved engine failure. The Manchester was withdrawn from operations in mid-1942 in favour of more capable aircraft. Its final role in RAF service was as instructional trainers for converting crews to the RAF's new Lancaster bombers; the Manchester and Lancaster shared nearly identical crew positions and fuselages. The type persisted in use for training purposes into 1943 before being completely retired.
Avro Manchester