On November 20, 2010, Pope Benedict XVI made Burke Cardinal-Deacon of Sant'Agata dei Goti, the fifth Archbishop of St. Louis to become a member of the College of Cardinals.
On February 5, 2011, the memorial of Saint Agatha, Burke took canonical possession of his titular church in Rome.

In October 2012, Burke was appointed the President of the Commission for Controversies at the 13th Ordinary General Assembly of the Synod of Bishops.

Burke was one of the cardinal electors who participated in the 2013 papal conclave that elected Pope Francis.

On December 16, 2013, Pope Francis made extensive changes to the influential Congregation for Bishops, the Vatican department that oversees the selection of new bishops.
Among them, Burke was not reappointed as a member.
It was speculated that Pope Francis removed Burke as a form of rebuke for his conservative ideology.
As a result, it "raise[d] eyebrows."
According to Archbishop Carlo Maria Viganò, the removal of Burke happened largely due to the influence of then-cardinal Theodore McCarrick, Archbishop Emeritus of Washington.
However, such a claim has not been independently verified.
On November 20, 2010, Pope Benedict XVI made Burke Cardinal-Deacon of Sant'Agata dei Goti, the fifth Archbishop of St. Louis to become a member of the College of Cardinals. On February 5, 2011, the memorial of Saint Agatha, Burke took canonical possession of his titular church in Rome.
In October 2012, Burke was appointed the President of the Commission for Controversies at the 13th Ordinary General Assembly of the Synod of Bishops.
Burke was one of the cardinal electors who participated in the 2013 papal conclave that elected Pope Francis.
On December 16, 2013, Pope Francis made extensive changes to the influential Congregation for Bishops, the Vatican department that oversees the selection of new bishops. Among them, Burke was not reappointed as a member. It was speculated that Pope Francis removed Burke as a form of rebuke for his conservative ideology. As a result, it "raise[d] eyebrows." According to Archbishop Carlo Maria Viganò, the removal of Burke happened largely due to the influence of then-cardinal Theodore McCarrick, Archbishop Emeritus of Washington. However, such a claim has not been independently verified.
Raymond Leo Burke