By the turn of the 20th century St. Anthony's became the only church downtown.
By the end of the first decade the parish's boundaries had become fixed to the central city with the founding of two parishes on top of the hill: Holy Family (1898) in the northwest part of the city and St. Paul the Apostle (1909) on the east side.
 
The grotto to the Blessed Virgin Mary on the north side of the church was added in the 1920s.
It was rebuilt in 1998 and the current statue was placed in it in 1999.

A major renovation was carried out in 1949 when a manufactured stone facing, or permastone, was put on the 1886 addition to the church, the school (original church) and the rectory.
This gave the parish complex a unified appearance.
The sacristy was also expanded along the south transept.
The north wing was also added to the school building.
This was the last addition made to the original building.
There was also an addition made to the rectory to create more living space for the resident clergy.
 
In the 1960s changes were made to facilitate the liturgical reforms of the Second Vatican Council.
While the communion rail was removed and a new free-standing altar was created so the priest could face the congregation, the old altars, frescos and statuary remain in the church.

One of the more colorful chapters in the parish's history was the Folk Masses of the 1970s.
Rev. James Grubb, the associate pastor, inspired the masses that included contemporary music played on guitars, colorful vestments, and young people sitting on the floor of the sanctuary.

In 1987 the parish celebrated its sesquicentennial.
To commemorate the occasion, a sculpture was commissioned and placed on the front of the church property facing Main Street.
It depicts Father Mazzuchelli, a Sister of Charity of the Blessed Virgin Mary, a child representing the children who attended the parish school, Col.
George Davenport (for whom the city of Davenport was named) and Antoine LeClaire.
The statue group stands atop a pedestal that encloses the church's original bell.
By the turn of the 20th century St. Anthony's became the only church downtown. By the end of the first decade the parish's boundaries had become fixed to the central city with the founding of two parishes on top of the hill: Holy Family (1898) in the northwest part of the city and St. Paul the Apostle (1909) on the east side.  
The grotto to the Blessed Virgin Mary on the north side of the church was added in the 1920s. It was rebuilt in 1998 and the current statue was placed in it in 1999.
A major renovation was carried out in 1949 when a manufactured stone facing, or permastone, was put on the 1886 addition to the church, the school (original church) and the rectory. This gave the parish complex a unified appearance. The sacristy was also expanded along the south transept. The north wing was also added to the school building. This was the last addition made to the original building. There was also an addition made to the rectory to create more living space for the resident clergy.  
In the 1960s changes were made to facilitate the liturgical reforms of the Second Vatican Council. While the communion rail was removed and a new free-standing altar was created so the priest could face the congregation, the old altars, frescos and statuary remain in the church.
One of the more colorful chapters in the parish's history was the Folk Masses of the 1970s. Rev. James Grubb, the associate pastor, inspired the masses that included contemporary music played on guitars, colorful vestments, and young people sitting on the floor of the sanctuary.
In 1987 the parish celebrated its sesquicentennial. To commemorate the occasion, a sculpture was commissioned and placed on the front of the church property facing Main Street. It depicts Father Mazzuchelli, a Sister of Charity of the Blessed Virgin Mary, a child representing the children who attended the parish school, Col. George Davenport (for whom the city of Davenport was named) and Antoine LeClaire. The statue group stands atop a pedestal that encloses the church's original bell.
St. Anthony's Catholic Church (Davenport, Iowa)