Cangzhou is located in eastern Hebei, immediately to the south of Tianjin, near the coast of the Bohai Sea of the Pacific Ocean.
Bordering prefecture-level cities are Hengshui to the southwest, Baoding to the west, and Langfang to the north.
It lies on the Beijing–Shanghai Railway.

The G1811 Huanghua–Shijiazhuang Expressway connects Cangzhou to Shijiazhuang, the provincial capital, and is linked to Beijing via both the G2 Beijing–Shanghai Expressway and G3 Beijing–Taipei Expressway, which are concurrent within the province, and to Shanghai via G2.
Cangzhou's Huanghua Harbour is the end of a main Chinese coal shipping railway, the Shuohuang Railway.
Other major highways serving Cangzhou's urban area are China National Highway 104 and 307.

Major airports located closest to Cangzhou include Beijing Capital Airport and Tianjin Airport.

The Grand Canal passes directly through Cangzhou, and a district of Cangzhou (Yunhe District) is named after it.
Cangzhou is located in eastern Hebei, immediately to the south of Tianjin, near the coast of the Bohai Sea of the Pacific Ocean. Bordering prefecture-level cities are Hengshui to the southwest, Baoding to the west, and Langfang to the north. It lies on the Beijing–Shanghai Railway.
The G1811 Huanghua–Shijiazhuang Expressway connects Cangzhou to Shijiazhuang, the provincial capital, and is linked to Beijing via both the G2 Beijing–Shanghai Expressway and G3 Beijing–Taipei Expressway, which are concurrent within the province, and to Shanghai via G2. Cangzhou's Huanghua Harbour is the end of a main Chinese coal shipping railway, the Shuohuang Railway. Other major highways serving Cangzhou's urban area are China National Highway 104 and 307.
Major airports located closest to Cangzhou include Beijing Capital Airport and Tianjin Airport.
The Grand Canal passes directly through Cangzhou, and a district of Cangzhou (Yunhe District) is named after it.
Cangzhou