The skull of Mierasaurus is overall similar to those of other turiasaurs, which have rounded snouts with retracted nostril openings.
The lower jaw of Mierasaurus becomes increasingly taller towards the front, which is like Camarasaurus but unlike the basal sauropod Jobaria.
A sharp ridge extends across the bottom edge of the front of the lower jaw, seen in both dicraeosaurids and diplodocids, and to some extent Camarasaurus.
The lower jaw bears thirteen teeth; the ones at the front are spatula-shaped while the ones at the rear are heart-shaped, which is a distinguishing characteristic of turiasaurs.
Compared to Camarasaurus, the teeth at the front of the jaw are more pointed and have taller crowns.
There are no well-developed vertical ridges on the outer surface of the teeth, in contrast to its closest relative Moabosaurus.

In Mierasaurus, the skull roof is overall flattened, lacking any convexities.
Unlike more derived sauropods but also seen in Turiasaurus, the frontal bone of Mierasaurus participates in the margin of the supratemporal fenestra.
Unique characteristics that differentiate Mierasaurus from other turiasaurs can be found in its braincase: a ridge known as the otosphenoidal ridge extends from the front of the paroccipital process—a bony spur to which neck muscles attach—and runs along its inner edge; and the occipital condyle, which articulates with the atlas, has a pair of rounded ridges on the sides of its articular surfaces (which Moabosaurus lacks).
Like Turiasaurus, Mierasaurus has a pair of foramina at the top end of the transverse nuchal crest on the supraoccipital bone.
Like in Moabosaurus, the downward projections known as the basal tubera on the basioccipital bone are L-shaped when viewed from the bottom.
The skull of Mierasaurus is overall similar to those of other turiasaurs, which have rounded snouts with retracted nostril openings. The lower jaw of Mierasaurus becomes increasingly taller towards the front, which is like Camarasaurus but unlike the basal sauropod Jobaria. A sharp ridge extends across the bottom edge of the front of the lower jaw, seen in both dicraeosaurids and diplodocids, and to some extent Camarasaurus. The lower jaw bears thirteen teeth; the ones at the front are spatula-shaped while the ones at the rear are heart-shaped, which is a distinguishing characteristic of turiasaurs. Compared to Camarasaurus, the teeth at the front of the jaw are more pointed and have taller crowns. There are no well-developed vertical ridges on the outer surface of the teeth, in contrast to its closest relative Moabosaurus.
In Mierasaurus, the skull roof is overall flattened, lacking any convexities. Unlike more derived sauropods but also seen in Turiasaurus, the frontal bone of Mierasaurus participates in the margin of the supratemporal fenestra. Unique characteristics that differentiate Mierasaurus from other turiasaurs can be found in its braincase: a ridge known as the otosphenoidal ridge extends from the front of the paroccipital process—a bony spur to which neck muscles attach—and runs along its inner edge; and the occipital condyle, which articulates with the atlas, has a pair of rounded ridges on the sides of its articular surfaces (which Moabosaurus lacks). Like Turiasaurus, Mierasaurus has a pair of foramina at the top end of the transverse nuchal crest on the supraoccipital bone. Like in Moabosaurus, the downward projections known as the basal tubera on the basioccipital bone are L-shaped when viewed from the bottom.
Mierasaurus