The route begins at the northern end of Cato Springs Road under the I-49 overpass in south Fayetteville.
The route runs briefly north with access to U.S. Highway 71 (US 71) with AR 265 before AR 265 becomes Cato Springs Road again and continues east.
AR 112 continues north as Razorback Road and runs north to run concurrently with AR 16, starting near Baum Stadium and continuing until AR 180 (Martin Luther King Jr. Boulevard).
AR 112 continues through the University of Arkansas campus, passing John McDonnell Field and Donald W. Reynolds Razorback Stadium.

After the stadium, AR 112 turns east and becomes West Maple Street and passes Dale Bumpers College of Agricultural, Food and Life Sciences and the Pat Walker Health Center.
The highway turns north and becomes Garland Avenue, which is a median-divided highway until Highway 112S/Wedington Drive/North Street.
The medians were added in 2009 after contention from the City of Fayetteville and residents.
Ultimately, it was decided to have one continuous median that becomes a turn lane, with separate bike lanes on both sides.
AR 112 continues north through Fayetteville, intersecting Wedington Drive just north of campus.
The route continues as an important artery through the city, crossing I-49/US 62/US 71 south of the Fayetteville Teardrop (I-49 exit 67).
AR 112 runs north from the expressway to Tontitown as Maestri Road, intersecting US 412 in Tontitown.
Continuning north through Elm Springs as Elm St., the route enters Benton County.

AR 112 runs north in a brief concurrency with AR 264 in Cave Springs before entering Bentonville and terminating at AR 12 near the Bentonville Municipal Airport.
The route begins at the northern end of Cato Springs Road under the I-49 overpass in south Fayetteville. The route runs briefly north with access to U.S. Highway 71 (US 71) with AR 265 before AR 265 becomes Cato Springs Road again and continues east. AR 112 continues north as Razorback Road and runs north to run concurrently with AR 16, starting near Baum Stadium and continuing until AR 180 (Martin Luther King Jr. Boulevard). AR 112 continues through the University of Arkansas campus, passing John McDonnell Field and Donald W. Reynolds Razorback Stadium.
After the stadium, AR 112 turns east and becomes West Maple Street and passes Dale Bumpers College of Agricultural, Food and Life Sciences and the Pat Walker Health Center. The highway turns north and becomes Garland Avenue, which is a median-divided highway until Highway 112S/Wedington Drive/North Street. The medians were added in 2009 after contention from the City of Fayetteville and residents. Ultimately, it was decided to have one continuous median that becomes a turn lane, with separate bike lanes on both sides. AR 112 continues north through Fayetteville, intersecting Wedington Drive just north of campus. The route continues as an important artery through the city, crossing I-49/US 62/US 71 south of the Fayetteville Teardrop (I-49 exit 67). AR 112 runs north from the expressway to Tontitown as Maestri Road, intersecting US 412 in Tontitown. Continuning north through Elm Springs as Elm St., the route enters Benton County.
AR 112 runs north in a brief concurrency with AR 264 in Cave Springs before entering Bentonville and terminating at AR 12 near the Bentonville Municipal Airport.
Arkansas Highway 112