Pico de Orizaba was important in pre-Hispanic cultures, such as those of the Nahuatl-speaking Aztecs and the Totonacs.
The volcano is part of many native mythologies.

During the Spanish Conquest of Mexico, Hernán Cortés passed through the foothills of Pico de Orizaba; the volcano and the surrounding mountains made his journey to Tenochtitlan more difficult and delayed him for many days.
During the 1600s, the Spanish Crown financed several roads to be built that would circumvent Citlaltépetl.
One of the roads was routed south of the volcano through the cities of Orizaba and Fortín de las Flores, which became the main trade route between Mexico City and Veracruz on the Gulf Coast.
A short road was later built by Jesuits to establish settlements at the base of Pico de Orizaba.
The Spanish used the volcano as a landmark to guide themselves to the port of Veracruz.
Many battles were fought near this volcano throughout Mexico's struggle for independence.

In 1839, Henri Galeotti was the first European to explore the volcano, but did not hike to the summit.
During the American occupation of Mexico in 1848, two American soldiers, F. Maynard and William F. Raynolds, were the first known hikers to reach the summit of Pico de Orizaba.
In 1851, the French explorer Alejandro Doignon also reached the summit ad found the flagpole left behind by the Americans in 1848.
During the mid-19th century Citlaltépetl was explored by many scientists, including the German botanist Hugo Fink, who was the first to record the numerous species of flora found on the volcano.
In 1873, Martin Tritschler raised the Mexican flag at the summit.

On December 16, 1936, President Lázaro Cárdenas, in an effort to protect the natural beauty of Pico de Orizaba, created a national park with an area of 19,750 hectares (48,800 acres) which included the volcano with the surrounding area and the settlements of Tlachichuca, Ciudad Serdán, La Perla, Mariano Escobedo, and Calcahualco.
The federal decree became federal law on January 4, 1937.
Pico de Orizaba was important in pre-Hispanic cultures, such as those of the Nahuatl-speaking Aztecs and the Totonacs. The volcano is part of many native mythologies.
During the Spanish Conquest of Mexico, Hernán Cortés passed through the foothills of Pico de Orizaba; the volcano and the surrounding mountains made his journey to Tenochtitlan more difficult and delayed him for many days. During the 1600s, the Spanish Crown financed several roads to be built that would circumvent Citlaltépetl. One of the roads was routed south of the volcano through the cities of Orizaba and Fortín de las Flores, which became the main trade route between Mexico City and Veracruz on the Gulf Coast. A short road was later built by Jesuits to establish settlements at the base of Pico de Orizaba. The Spanish used the volcano as a landmark to guide themselves to the port of Veracruz. Many battles were fought near this volcano throughout Mexico's struggle for independence.
In 1839, Henri Galeotti was the first European to explore the volcano, but did not hike to the summit. During the American occupation of Mexico in 1848, two American soldiers, F. Maynard and William F. Raynolds, were the first known hikers to reach the summit of Pico de Orizaba. In 1851, the French explorer Alejandro Doignon also reached the summit ad found the flagpole left behind by the Americans in 1848. During the mid-19th century Citlaltépetl was explored by many scientists, including the German botanist Hugo Fink, who was the first to record the numerous species of flora found on the volcano. In 1873, Martin Tritschler raised the Mexican flag at the summit.
On December 16, 1936, President Lázaro Cárdenas, in an effort to protect the natural beauty of Pico de Orizaba, created a national park with an area of 19,750 hectares (48,800 acres) which included the volcano with the surrounding area and the settlements of Tlachichuca, Ciudad Serdán, La Perla, Mariano Escobedo, and Calcahualco. The federal decree became federal law on January 4, 1937.
Pico de Orizaba