By the early 2000s, he was frequently cast in romantic comedies, including The Wedding Planner and How to Lose a Guy in 10 Days, both of which were successful at the box office.
During this period, he appeared as a firefighter in the low-budget film Tiptoes, with Kate Beckinsale, in Two for the Money as a protégé to Al Pacino's gambling mogul, and in Frailty with Bill Paxton, who also directed.

McConaughey starred in the 2005 feature film Sahara, along with Steve Zahn and Penélope Cruz.
Prior to the release of the film, he promoted it by sailing down the Amazon River and trekking to Mali.
That same year, McConaughey was named People magazine's "Sexiest Man Alive" for 2005.
In 2006, he co-starred with Sarah Jessica Parker in the romantic comedy Failure to Launch and as Marshall head football coach Jack Lengyel in We Are Marshall.
McConaughey also provided voice work in an ad campaign for the Peace Corps in late 2006.
He replaced Owen Wilson in Ben Stiller's Tropic Thunder after Wilson's suicide attempt.
On January 21, 2008, McConaughey became the new spokesman for the national radio campaign, "Beef: It's What's for Dinner", replacing Sam Elliott.
By the early 2000s, he was frequently cast in romantic comedies, including The Wedding Planner and How to Lose a Guy in 10 Days, both of which were successful at the box office. During this period, he appeared as a firefighter in the low-budget film Tiptoes, with Kate Beckinsale, in Two for the Money as a protégé to Al Pacino's gambling mogul, and in Frailty with Bill Paxton, who also directed.
McConaughey starred in the 2005 feature film Sahara, along with Steve Zahn and Penélope Cruz. Prior to the release of the film, he promoted it by sailing down the Amazon River and trekking to Mali. That same year, McConaughey was named People magazine's "Sexiest Man Alive" for 2005. In 2006, he co-starred with Sarah Jessica Parker in the romantic comedy Failure to Launch and as Marshall head football coach Jack Lengyel in We Are Marshall. McConaughey also provided voice work in an ad campaign for the Peace Corps in late 2006. He replaced Owen Wilson in Ben Stiller's Tropic Thunder after Wilson's suicide attempt. On January 21, 2008, McConaughey became the new spokesman for the national radio campaign, "Beef: It's What's for Dinner", replacing Sam Elliott.
Matthew McConaughey