Owensboro is located at the crook of a bend in the Ohio River, 37 miles (60 km) southeast of Evansville, Indiana.

According to the United States Census Bureau, Owensboro has a total area of 20.4 square miles (52.9 km²), of which 19.1 square miles (49.5 km²) is land and 1.3 square miles (3.4 km²), or 6.47%, is water.
Owensboro is located at the crook of a bend in the Ohio River, 37 miles (60 km) southeast of Evansville, Indiana.
According to the United States Census Bureau, Owensboro has a total area of 20.4 square miles (52.9 km²), of which 19.1 square miles (49.5 km²) is land and 1.3 square miles (3.4 km²), or 6.47%, is water.
Owensboro, Kentucky