In 1856 Burne-Jones became engaged to Georgiana "Georgie" MacDonald (1840–1920), one of the MacDonald sisters.
She was training to be a painter, and was the sister of Burne-Jones's old school friend.
The couple married in 1860, after which she made her own work in woodcuts, and became a close friend of George Eliot. (
Another MacDonald sister married the artist Sir Edward Poynter, a further sister married the ironmaster Alfred Baldwin and was the mother of the Prime Minister Stanley Baldwin, and yet another sister was the mother of Rudyard Kipling.
Kipling and Baldwin were thus Burne-Jones's nephews by marriage).

Georgiana gave birth to a son, Philip, in 1861.
A second son, born in the winter of 1864 while Georgiana became gravely ill with scarlet fever, died soon after birth.
The family then moved to 41 Kensington Square, and their daughter Margaret was born there in 1866.
In 1867 Burne-Jones and his family settled at the Grange, an 18th-century house set in a garden in North End, Fulham, London.
For the 1870s Burne-Jones did not exhibit, following a number of bitterly hostile attacks in the press, and a passionate affair (described as the "emotional climax of his life") with his Greek model Maria Zambaco, which ended with her trying to commit suicide by throwing herself in Regent's Canal.
During these difficult years Georgiana developed a friendship with Morris, whose wife Jane had fallen in love with Rossetti.
Morris and Georgie may have been in love, but if he asked her to leave her husband, she refused.
In the end, the Burne-Joneses remained together, as did the Morrises, but Morris and Georgiana were close for the rest of their lives.

In 1880 the Burne-Joneses bought Prospect House in Rottingdean, near Brighton in Sussex, as their holiday home, and soon after the next door Aubrey Cottage to create North End House, reflecting the fact that their Fulham home was in North End Road. (
Years later, in 1923, Sir Roderick Jones, head of Reuters, and his wife, playwright and novelist Enid Bagnold, were to add the adjacent Gothic House to the property, which became the inspiration and setting for her play The Chalk Garden).

His troubled son Philip, who became a successful portrait painter, died in 1926.
His adored daughter Margaret (died 1953) married John William Mackail (1850–1945), the friend and biographer of Morris, and Professor of Poetry at Oxford from 1911–1916.
Their children were the novelists Angela Thirkell and Denis Mackail.
In an edition of the boys' magazine, Chums (No.
 227, Vol.
  V, 13 January 1897), an article on Burne-Jones stated that "....his pet grandson used to be punished by being sent to stand in a corner with his face to the wall.
One day on being sent there he was delighted to find the wall prettily decorated with fairies, flowers, birds, and bunnies.
His indulgent grandfather had utilised his talent to alleviate the tedium of his favourite's period of penance."
In 1856 Burne-Jones became engaged to Georgiana "Georgie" MacDonald (1840–1920), one of the MacDonald sisters. She was training to be a painter, and was the sister of Burne-Jones's old school friend. The couple married in 1860, after which she made her own work in woodcuts, and became a close friend of George Eliot. (Another MacDonald sister married the artist Sir Edward Poynter, a further sister married the ironmaster Alfred Baldwin and was the mother of the Prime Minister Stanley Baldwin, and yet another sister was the mother of Rudyard Kipling. Kipling and Baldwin were thus Burne-Jones's nephews by marriage).
Georgiana gave birth to a son, Philip, in 1861. A second son, born in the winter of 1864 while Georgiana became gravely ill with scarlet fever, died soon after birth. The family then moved to 41 Kensington Square, and their daughter Margaret was born there in 1866. In 1867 Burne-Jones and his family settled at the Grange, an 18th-century house set in a garden in North End, Fulham, London. For the 1870s Burne-Jones did not exhibit, following a number of bitterly hostile attacks in the press, and a passionate affair (described as the "emotional climax of his life") with his Greek model Maria Zambaco, which ended with her trying to commit suicide by throwing herself in Regent's Canal. During these difficult years Georgiana developed a friendship with Morris, whose wife Jane had fallen in love with Rossetti. Morris and Georgie may have been in love, but if he asked her to leave her husband, she refused. In the end, the Burne-Joneses remained together, as did the Morrises, but Morris and Georgiana were close for the rest of their lives.
In 1880 the Burne-Joneses bought Prospect House in Rottingdean, near Brighton in Sussex, as their holiday home, and soon after the next door Aubrey Cottage to create North End House, reflecting the fact that their Fulham home was in North End Road. (Years later, in 1923, Sir Roderick Jones, head of Reuters, and his wife, playwright and novelist Enid Bagnold, were to add the adjacent Gothic House to the property, which became the inspiration and setting for her play The Chalk Garden).
His troubled son Philip, who became a successful portrait painter, died in 1926. His adored daughter Margaret (died 1953) married John William Mackail (1850–1945), the friend and biographer of Morris, and Professor of Poetry at Oxford from 1911–1916. Their children were the novelists Angela Thirkell and Denis Mackail. In an edition of the boys' magazine, Chums (No. 227, Vol.  V, 13 January 1897), an article on Burne-Jones stated that "....his pet grandson used to be punished by being sent to stand in a corner with his face to the wall. One day on being sent there he was delighted to find the wall prettily decorated with fairies, flowers, birds, and bunnies. His indulgent grandfather had utilised his talent to alleviate the tedium of his favourite's period of penance."
Edward Burne-Jones