Although he had performed primarily in comedies, Reynolds underwent intense physical training to play an action role as the character of Hannibal King in the 2004 film Blade: Trinity.
The same year, he made a cameo appearance in Harold & Kumar Go to White Castle as a nurse.
Reynolds played George Lutz in the 2005 remake of the 1979 horror film The Amityville Horror.
Also, in 2005, he played a waiter named Monty in Waiting..., and appeared as music executive Chris Brander in the romantic comedy Just Friends alongside Amy Smart and Anna Faris.
Additionally, he played an FBI agent alongside Ray Liotta in the 2006 crime action film Smokin' Aces.
Reynolds played the protagonist in the 2008 film Definitely, Maybe.
He also appeared in the second-season finale of the television series Scrubs.
In 2007, Reynolds guest-starred as Brendan's friend Hams in the episode "Douchebag in the City" of the TBS sitcom My Boys.

Reynolds portrayed Wade Wilson / Weapon XI in a supporting role in the prequel X-Men film, X-Men Origins: Wolverine, which was released in 2009.
He had previously spoken of his interest and involvement in a possible film adaptation of Deadpool with screenwriter David S. Goyer as far back as 2005.
2009 also saw Reynolds portray Andrew Paxton, opposite Sandra Bullock, in The Proposal, and Mike Connell in Adventureland.

In 2010, Reynolds starred in the Spanish and American thriller Buried, which screened at the Sundance Film Festival.
In June 2010, Reynolds was invited to join the Academy of Motion Picture Arts and Sciences.
Reynolds portrayed the Hal Jordan version of superhero Green Lantern in Warner Bros.' film Green Lantern, which was released on June 17, 2011.
The film did not fare well either financially or critically, but his role made him one of the few actors to headline films based on both Marvel and DC characters.
In 2011, he co-starred in the comedy The Change-Up, as well as narrating the documentary film The Whale.
In 2012, he portrayed an agent in Safe House, alongside Denzel Washington.
He then had starring roles in two Dreamworks Animation feature films, The Croods and Turbo, both released in 2013.
His next role was portraying Nick Walker in the Universal Pictures film adaptation of Dark Horse Comics' R.I.P.D. (Rest in Peace Department), which was released in 2013.
Reynolds went on to star in low-budget films, The Voices and The Captive in 2014, as well as Mississippi Grind the following year.
This was followed by a supporting role in the financially successful biographical film, Woman in Gold, before he returned to the thriller genre with Self/Less, also in 2015.
Although he had performed primarily in comedies, Reynolds underwent intense physical training to play an action role as the character of Hannibal King in the 2004 film Blade: Trinity. The same year, he made a cameo appearance in Harold & Kumar Go to White Castle as a nurse. Reynolds played George Lutz in the 2005 remake of the 1979 horror film The Amityville Horror. Also, in 2005, he played a waiter named Monty in Waiting..., and appeared as music executive Chris Brander in the romantic comedy Just Friends alongside Amy Smart and Anna Faris. Additionally, he played an FBI agent alongside Ray Liotta in the 2006 crime action film Smokin' Aces. Reynolds played the protagonist in the 2008 film Definitely, Maybe. He also appeared in the second-season finale of the television series Scrubs. In 2007, Reynolds guest-starred as Brendan's friend Hams in the episode "Douchebag in the City" of the TBS sitcom My Boys.
Reynolds portrayed Wade Wilson / Weapon XI in a supporting role in the prequel X-Men film, X-Men Origins: Wolverine, which was released in 2009. He had previously spoken of his interest and involvement in a possible film adaptation of Deadpool with screenwriter David S. Goyer as far back as 2005. 2009 also saw Reynolds portray Andrew Paxton, opposite Sandra Bullock, in The Proposal, and Mike Connell in Adventureland.
In 2010, Reynolds starred in the Spanish and American thriller Buried, which screened at the Sundance Film Festival. In June 2010, Reynolds was invited to join the Academy of Motion Picture Arts and Sciences. Reynolds portrayed the Hal Jordan version of superhero Green Lantern in Warner Bros.' film Green Lantern, which was released on June 17, 2011. The film did not fare well either financially or critically, but his role made him one of the few actors to headline films based on both Marvel and DC characters. In 2011, he co-starred in the comedy The Change-Up, as well as narrating the documentary film The Whale. In 2012, he portrayed an agent in Safe House, alongside Denzel Washington. He then had starring roles in two Dreamworks Animation feature films, The Croods and Turbo, both released in 2013. His next role was portraying Nick Walker in the Universal Pictures film adaptation of Dark Horse Comics' R.I.P.D. (Rest in Peace Department), which was released in 2013. Reynolds went on to star in low-budget films, The Voices and The Captive in 2014, as well as Mississippi Grind the following year. This was followed by a supporting role in the financially successful biographical film, Woman in Gold, before he returned to the thriller genre with Self/Less, also in 2015.
Ryan Reynolds