She was commissioned on 28 January 2006 at NAS Pensacola, Commander Michael VanDurick in command, and six days later departed for her homeport in Norfolk, Va. to join the Atlantic Fleet.

She departed Norfolk for her maiden deployment in July 2007, visiting various nations around the Mediterranean Sea and the Black Sea.
In August 2007, while the ship was visiting Sevastopol to conduct drills with the Ukrainian Navy, a 1,100 pounds (500 kg) naval mine from the Second World War was discovered 500 yards from the vessel.
The mine was secured before it could damage the ship.
Also during that visit, she became the first US Navy ship to land a
Ukrainian Navy helicopter.
She also conducted Reliant Mermaid 2007 with the Turkish and Israeli Navies.

On that deployment, she circumnavigated the continent of Africa as part of Task Group 60.5, the US Navy's Southeast Africa task force.
 She returned home on 19 December that year.

In early June 2008, Forrest Sherman deployed for three months in support of U.S. Southern Command's Partnership of the Americas 2008 (POA 08) operation.
She returned home on 29 August 2008.

On 25 November 2019, Forrest Sherman captured a stateless dhow carrying a large cache of Iranian missile parts destined for Yemen.
She was commissioned on 28 January 2006 at NAS Pensacola, Commander Michael VanDurick in command, and six days later departed for her homeport in Norfolk, Va. to join the Atlantic Fleet.
She departed Norfolk for her maiden deployment in July 2007, visiting various nations around the Mediterranean Sea and the Black Sea. In August 2007, while the ship was visiting Sevastopol to conduct drills with the Ukrainian Navy, a 1,100 pounds (500 kg) naval mine from the Second World War was discovered 500 yards from the vessel. The mine was secured before it could damage the ship. Also during that visit, she became the first US Navy ship to land a
Ukrainian Navy helicopter. She also conducted Reliant Mermaid 2007 with the Turkish and Israeli Navies.
On that deployment, she circumnavigated the continent of Africa as part of Task Group 60.5, the US Navy's Southeast Africa task force.  She returned home on 19 December that year.
In early June 2008, Forrest Sherman deployed for three months in support of U.S. Southern Command's Partnership of the Americas 2008 (POA 08) operation. She returned home on 29 August 2008.
On 25 November 2019, Forrest Sherman captured a stateless dhow carrying a large cache of Iranian missile parts destined for Yemen.
USS Forrest Sherman (DDG-98)