Activated in mid-1942 at Davis–Monthan Field, Arizona as a North American B-25 Mitchell medium bomber squadron, but moved on paper the same day to Jackson Army Air Base, Mississippi.
 The squadron trained under Third Air Force in the southeastern United States.
It was deployed initially to England in September 1942 and flew some missions under VIII Bomber Command over German-occupied France; attacking enemy troop formations, bridges and airfields.
It was part of Operation Torch, the invasion of North Africa in November 1942, being deployed to the new Mediterranean Theater of Operations.
The squadron was assigned to the Twelfth Air Force in French Morocco in November, when it was engaged primarily in support and interdictory operations, bombing marshalling yards, rail lines, highways, bridges, viaducts, troop concentrations, gun emplacements, shipping, harbors and other objectives in North Africa.

The squadron also engaged in psychological warfare missions, dropping propaganda leaflets behind enemy lines.
It took part in the Allied operations against Axis forces in North Africa during March–May 1943, the reduction of Pantelleria and Lampedusa islands during June and the invasion of Sicily in July.
It was also involved in the landing on the Italian mainland at Salerno in September, the Allied advance toward Rome during January–June 1944, Operation Dragoon, the invasion of Southern France in August 1944 and Allied operations in northern Italy from September 1944 to April 1945.
 It was inactivated in Italy after the German capitulation in September 1945.
Activated in mid-1942 at Davis–Monthan Field, Arizona as a North American B-25 Mitchell medium bomber squadron, but moved on paper the same day to Jackson Army Air Base, Mississippi.  The squadron trained under Third Air Force in the southeastern United States. It was deployed initially to England in September 1942 and flew some missions under VIII Bomber Command over German-occupied France; attacking enemy troop formations, bridges and airfields. It was part of Operation Torch, the invasion of North Africa in November 1942, being deployed to the new Mediterranean Theater of Operations. The squadron was assigned to the Twelfth Air Force in French Morocco in November, when it was engaged primarily in support and interdictory operations, bombing marshalling yards, rail lines, highways, bridges, viaducts, troop concentrations, gun emplacements, shipping, harbors and other objectives in North Africa.
The squadron also engaged in psychological warfare missions, dropping propaganda leaflets behind enemy lines. It took part in the Allied operations against Axis forces in North Africa during March–May 1943, the reduction of Pantelleria and Lampedusa islands during June and the invasion of Sicily in July. It was also involved in the landing on the Italian mainland at Salerno in September, the Allied advance toward Rome during January–June 1944, Operation Dragoon, the invasion of Southern France in August 1944 and Allied operations in northern Italy from September 1944 to April 1945.  It was inactivated in Italy after the German capitulation in September 1945.
379th Bombardment Squadron