Amtrak, the national passenger rail system, provides service to Mattoon.
 Amtrak Train 59, the southbound City of New Orleans, is scheduled to depart Mattoon at 11:13pm daily with service to Effingham, Centralia, Carbondale, Fulton, Newbern-Dyersburg, Memphis, Greenwood, Yazoo City, Jackson, Hazlehurst, Brookhaven, McComb, Hammond, and New Orleans.
 Amtrak Train 58, the northbound City of New Orleans, is scheduled to depart Mattoon at 5:23am daily with service to Champaign-Urbana, Kankakee, Homewood, and Chicago.
 Mattoon is also served by Amtrak Train 390/391, the Saluki, daily in the morning, and Amtrak Train 392/393, the Illini, daily in the afternoon/evening.
Both the Saluki and the Illini operate between Chicago and Carbondale.

The Illinois Central Station in the heart of downtown Mattoon has recently been totally renovated.
 It is handicap accessible with an elevator to the lower level train platform.
 Funding of $2.5 million was obtained for it via the 2005 Transportation Bill.
 Today the station is unmanned; passengers boarding at the Mattoon station must order their tickets by telephone or online.
Amtrak, the national passenger rail system, provides service to Mattoon.  Amtrak Train 59, the southbound City of New Orleans, is scheduled to depart Mattoon at 11:13pm daily with service to Effingham, Centralia, Carbondale, Fulton, Newbern-Dyersburg, Memphis, Greenwood, Yazoo City, Jackson, Hazlehurst, Brookhaven, McComb, Hammond, and New Orleans.  Amtrak Train 58, the northbound City of New Orleans, is scheduled to depart Mattoon at 5:23am daily with service to Champaign-Urbana, Kankakee, Homewood, and Chicago.  Mattoon is also served by Amtrak Train 390/391, the Saluki, daily in the morning, and Amtrak Train 392/393, the Illini, daily in the afternoon/evening. Both the Saluki and the Illini operate between Chicago and Carbondale.
The Illinois Central Station in the heart of downtown Mattoon has recently been totally renovated.  It is handicap accessible with an elevator to the lower level train platform.  Funding of $2.5 million was obtained for it via the 2005 Transportation Bill.  Today the station is unmanned; passengers boarding at the Mattoon station must order their tickets by telephone or online.
Mattoon, Illinois