Hompesch was born in the village of Bolheim, now part of the town of Zülpich in the Eifel region.
He received the baptismal names of Ferdinand Joseph Antoine Herman Louis.
He was admitted to the Knights Hospitaller on 10 July 1761, at the age of 14.
For this, he needed to obtain a dispensation from the Holy See, serving as a page to the Grand Master Manuel Pinto da Fonseca.
By 1768, he had been promoted to the rank of castellan, and in 1770, he had advanced to the rank of lieutenant, responsible for the inspection of ships and fortifications of the Order.
In 1774 he was given responsibility for the island's munitions.

In late 1775, Hompesch was appointed as the Order's ambassador at the court of the Holy Roman Emperor in Vienna, a post he held for the next 25 years.
The following year, he was also raised to the rank of Knight Grand Cross, making him a member of the Standing Council of the Order.
During this period, he made efforts to re-unite the Protestant Bailiwick of Brandenburg with the Order; these efforts were unsuccessful, largely due to the opposition of the German knights.
In the following years, he received charge of the commandery in Rothenburg (1777), followed by those in Herford (1783), Basel and Dorlisheim (1785), Sulz, Colmar and Mülhausen (1786) as well as Villingen, in the Black Forest (1796).
He was appointed Grand Bailiff of the German langue, based in Brandenburg, in 1796.

On 17 July 1797 Hompesch was elected Grand Master, which made him a Prince of the Church.
As Grand Master, he raised the towns of Żabbar, Żejtun and Siġġiewi to the status of cities.
Hompesch was born in the village of Bolheim, now part of the town of Zülpich in the Eifel region. He received the baptismal names of Ferdinand Joseph Antoine Herman Louis. He was admitted to the Knights Hospitaller on 10 July 1761, at the age of 14. For this, he needed to obtain a dispensation from the Holy See, serving as a page to the Grand Master Manuel Pinto da Fonseca. By 1768, he had been promoted to the rank of castellan, and in 1770, he had advanced to the rank of lieutenant, responsible for the inspection of ships and fortifications of the Order. In 1774 he was given responsibility for the island's munitions.
In late 1775, Hompesch was appointed as the Order's ambassador at the court of the Holy Roman Emperor in Vienna, a post he held for the next 25 years. The following year, he was also raised to the rank of Knight Grand Cross, making him a member of the Standing Council of the Order. During this period, he made efforts to re-unite the Protestant Bailiwick of Brandenburg with the Order; these efforts were unsuccessful, largely due to the opposition of the German knights. In the following years, he received charge of the commandery in Rothenburg (1777), followed by those in Herford (1783), Basel and Dorlisheim (1785), Sulz, Colmar and Mülhausen (1786) as well as Villingen, in the Black Forest (1796). He was appointed Grand Bailiff of the German langue, based in Brandenburg, in 1796.
On 17 July 1797 Hompesch was elected Grand Master, which made him a Prince of the Church. As Grand Master, he raised the towns of Żabbar, Żejtun and Siġġiewi to the status of cities.
Ferdinand von Hompesch zu Bolheim