Millikin's art often includes self-portraits as well as portraits of celebrities and political figures.
His work often incorporates mixed media and  found objects, such as packages of candy, paper currency, and spiders.
His large-scale artwork takes full advantage of the internet's formal possibilities, and has incorporated animation and winding "infinite canvas" designs, going beyond the limited sizes and shapes of conventional printed pages.
Millikin's works range from those made almost completely of text (including  calligraphy, typography, anagrams, ambigrams, free verse, and cut-up technique poetry) to those that are optical illusions or completely abstract.
Millikin's artwork has been published in books, serialized in newspapers, and displayed in art museums.

Danger Beasts: Since 2016, Millikin has created the Danger Beast series of street art portraits of endangered animals created out of endangered plants, including a portrait of Harambe the gorilla made from Venus flytraps.

Made of Money, a series of portraits of accomplished historical figures who died in poverty, created from cut up paper currency woven together.
Portraits in the series have included Nikola Tesla, Hedy Lamarr, Joe Louis, Vincent Van Gogh, and Edgar Allan Poe.
Millikin created the portraits as a statement on economc inequality, as a reminder "that our best people aren't always rewarded with wealth, and that our wealthiest people aren't always our best."
As part of the ArtPrize festival in 2017, Millikin created a small fold-up book of the series and installed it inside one of the small PO Boxes at the local Post Office, as a critique of the large scale pieces that typically dominate the festival.
Since the ArtPrize festival was created by the wealthy family of President Donald Trump's Education Secretary Betsy DeVos, the installation was widely seen as an attack on the perceived greed and unearned wealth of DeVos and Trump.

Totally Sweet, a series of pop art, large-scale portraits of monsters, each created from  thousands of packages of Halloween candy and a single spider.
Millikin uses over 40 different kinds of candy, and a single portrait can take between 5,000 and 10,000 candies.
Included in the series are portraits of such monsters as Freddy Krueger, Lily Munster, Gort, Godzilla and the Bride of Frankenstein.
Millikin compares his artistic technique of building large monsters from many smaller parts to the similar techniques Victor Frankenstein used to create his monster.

Hollywood Witch Trials, a series of painted portraits of celebrities like Paris Hilton and Lindsay Lohan based on their crime mug shots, stylized to look like witches, and combined with excerpts from transcripts of the Salem Witch Trials.
The portraits are characterized by brilliantly colored paint brushed and smeared into  expressionist swirls and spirals.

American Mayhem, a series that uses optical illusions to transform the flag of the United States into cityscapes filled with monsters, and incorporates ambigram calligraphy that reads when the paintings are hung upside down.
Inverting a national flag in such a way is a commonly used distress signal.

Witches and Stitches, a series of early digital comics, from the 1980s, which were the first webcomics ever published.
This unauthorized Wizard of Oz parody comic was published by Millikin on CompuServe as early as 1985 when he was in elementary school.
Publishing on Compuserve allowed Millikin to self-publish, avoiding censorship.
Witches and Stitches was popular with audiences around the world and Millikin's success inspired many artists to create their own webcomics.
Copies of Witches and Stitches are now often difficult to find because Millikin was threatened with a lawsuit over the comic.
Millikin's outspoken autobiographical style paved the way for other artists to express their thoughts and opinions on the web.

Literally Impossible, a series of Op art paintings created as answers to questions from a literacy test used to deny voting rights to African-Americans in the American south before the Voting Rights Act of 196
Millikin's art often includes self-portraits as well as portraits of celebrities and political figures. His work often incorporates mixed media and  found objects, such as packages of candy, paper currency, and spiders. His large-scale artwork takes full advantage of the internet's formal possibilities, and has incorporated animation and winding "infinite canvas" designs, going beyond the limited sizes and shapes of conventional printed pages. Millikin's works range from those made almost completely of text (including  calligraphy, typography, anagrams, ambigrams, free verse, and cut-up technique poetry) to those that are optical illusions or completely abstract. Millikin's artwork has been published in books, serialized in newspapers, and displayed in art museums.
Danger Beasts: Since 2016, Millikin has created the Danger Beast series of street art portraits of endangered animals created out of endangered plants, including a portrait of Harambe the gorilla made from Venus flytraps.
Made of Money, a series of portraits of accomplished historical figures who died in poverty, created from cut up paper currency woven together. Portraits in the series have included Nikola Tesla, Hedy Lamarr, Joe Louis, Vincent Van Gogh, and Edgar Allan Poe. Millikin created the portraits as a statement on economc inequality, as a reminder "that our best people aren't always rewarded with wealth, and that our wealthiest people aren't always our best." As part of the ArtPrize festival in 2017, Millikin created a small fold-up book of the series and installed it inside one of the small PO Boxes at the local Post Office, as a critique of the large scale pieces that typically dominate the festival. Since the ArtPrize festival was created by the wealthy family of President Donald Trump's Education Secretary Betsy DeVos, the installation was widely seen as an attack on the perceived greed and unearned wealth of DeVos and Trump.
Totally Sweet, a series of pop art, large-scale portraits of monsters, each created from  thousands of packages of Halloween candy and a single spider. Millikin uses over 40 different kinds of candy, and a single portrait can take between 5,000 and 10,000 candies. Included in the series are portraits of such monsters as Freddy Krueger, Lily Munster, Gort, Godzilla and the Bride of Frankenstein. Millikin compares his artistic technique of building large monsters from many smaller parts to the similar techniques Victor Frankenstein used to create his monster.
Hollywood Witch Trials, a series of painted portraits of celebrities like Paris Hilton and Lindsay Lohan based on their crime mug shots, stylized to look like witches, and combined with excerpts from transcripts of the Salem Witch Trials. The portraits are characterized by brilliantly colored paint brushed and smeared into  expressionist swirls and spirals.
American Mayhem, a series that uses optical illusions to transform the flag of the United States into cityscapes filled with monsters, and incorporates ambigram calligraphy that reads when the paintings are hung upside down. Inverting a national flag in such a way is a commonly used distress signal.
Witches and Stitches, a series of early digital comics, from the 1980s, which were the first webcomics ever published. This unauthorized Wizard of Oz parody comic was published by Millikin on CompuServe as early as 1985 when he was in elementary school. Publishing on Compuserve allowed Millikin to self-publish, avoiding censorship. Witches and Stitches was popular with audiences around the world and Millikin's success inspired many artists to create their own webcomics. Copies of Witches and Stitches are now often difficult to find because Millikin was threatened with a lawsuit over the comic. Millikin's outspoken autobiographical style paved the way for other artists to express their thoughts and opinions on the web.
Literally Impossible, a series of Op art paintings created as answers to questions from a literacy test used to deny voting rights to African-Americans in the American south before the Voting Rights Act of 196
Eric Millikin