Jerome signed for Birmingham City on 31 May 2006, for a transfer fee reported as an initial £3 million, potentially rising to £4m.
Jerome made his debut as a 66th-minute substitute against Colchester United at St Andrew's on 5 August.
However, it was a debut to forget, as he was sent off within five minutes of entering play elbowing an opponent in the face.
He netted his first goal for Birmingham against Queens Park Rangers at Loftus Road on 12 September.
Jerome had a slow first season at St Andrew's by his own admission, scoring just 9 times in 44 games in all competitions.

Jerome scored his first Premier League goal after 32 seconds of the away match against Derby County on 25 August 2007; his second goal of that game confirmed Birmingham's first win of the 2007–08 season.
He finished the season as Birmingham's second top goal scorer with 7 goals in 33 games as Birmingham were relegated.
However, the Blues immediately bounced back in the 2008–09 season by finishing second in the Championship.
Jerome's 10 goals in 45 appearances were only bettered by veteran partner Kevin Phillips in the Birmingham attack.
He scored the first goal in the West Midlands derby match against Wolverhampton Wanderers as Birmingham won 2–0.

In July 2009, Jerome signed a new five-year contract with the club.
He scored a spectacular first goal of the 2009–10 season to give his club a 2–1 lead against Liverpool, described as "the kind of goal that only the likes of Gerrard usually scores at Anfield"; he "fended off the irritation of Mascherano and unleashed a thunderous shot which dipped over keeper Reina."
Jerome hit a purple patch as the Blues notched up a club-record fifteen consecutive games unbeaten in the Premier League, scoring crucial goals against Stoke City, Manchester United and two versus Blackburn Rovers.
His tenth goal of the season, a header from James McFadden's cross, came in a 5–1 defeat away to Manchester City.
Two weeks after the final game of the season, Jerome's goals total rose to 11 when he was awarded an extra goal by the Dubious Goals Committee for his attempt against Burnley, which had originally been given as an own goal by Brian Jensen.

Jerome was a 92nd-minute substitute as Birmingham won the 2011 League Cup, defeating favourites Arsenal 2–1 at Wembley Stadium.
Jerome signed for Birmingham City on 31 May 2006, for a transfer fee reported as an initial £3 million, potentially rising to £4m. Jerome made his debut as a 66th-minute substitute against Colchester United at St Andrew's on 5 August. However, it was a debut to forget, as he was sent off within five minutes of entering play elbowing an opponent in the face. He netted his first goal for Birmingham against Queens Park Rangers at Loftus Road on 12 September. Jerome had a slow first season at St Andrew's by his own admission, scoring just 9 times in 44 games in all competitions.
Jerome scored his first Premier League goal after 32 seconds of the away match against Derby County on 25 August 2007; his second goal of that game confirmed Birmingham's first win of the 2007–08 season. He finished the season as Birmingham's second top goal scorer with 7 goals in 33 games as Birmingham were relegated. However, the Blues immediately bounced back in the 2008–09 season by finishing second in the Championship. Jerome's 10 goals in 45 appearances were only bettered by veteran partner Kevin Phillips in the Birmingham attack. He scored the first goal in the West Midlands derby match against Wolverhampton Wanderers as Birmingham won 2–0.
In July 2009, Jerome signed a new five-year contract with the club. He scored a spectacular first goal of the 2009–10 season to give his club a 2–1 lead against Liverpool, described as "the kind of goal that only the likes of Gerrard usually scores at Anfield"; he "fended off the irritation of Mascherano and unleashed a thunderous shot which dipped over keeper Reina." Jerome hit a purple patch as the Blues notched up a club-record fifteen consecutive games unbeaten in the Premier League, scoring crucial goals against Stoke City, Manchester United and two versus Blackburn Rovers. His tenth goal of the season, a header from James McFadden's cross, came in a 5–1 defeat away to Manchester City. Two weeks after the final game of the season, Jerome's goals total rose to 11 when he was awarded an extra goal by the Dubious Goals Committee for his attempt against Burnley, which had originally been given as an own goal by Brian Jensen.
Jerome was a 92nd-minute substitute as Birmingham won the 2011 League Cup, defeating favourites Arsenal 2–1 at Wembley Stadium.
Cameron Jerome