Pinel was born in Jonquières, the South of France, in the modern department of Tarn.
He was the son and nephew of physicians.
After receiving a degree from the faculty of medicine in Toulouse, he studied an additional four years at the Faculty of Medicine of Montpellier.
He arrived in Paris in 1778.

He spent fifteen years earning his living as a writer, translator, and editor because the restrictive regulations of the old regime prevented him from practicing medicine in Paris.
The faculty did not recognize a degree from a provincial university like Toulouse.
He failed twice in a competition which would have awarded him funds to continue his studies.
In the second competition, the jury stressed his ‘painful’ mediocrity in all areas of medical knowledge, an assessment seemingly so grossly incompatible with his later intellectual accomplishments that political motives have been suggested.
Discouraged, Pinel considered emigrating to America.
In 1784 he became editor of the medical journal the Gazette de santé, a four-page weekly.
He was also known among natural scientists as a regular contributor to the Journal de physique.
He studied mathematics, translated medical works into French, and undertook botanical expeditions.

At about this time he began to develop an intense interest in the study of mental illness.
The incentive was a personal one.
A friend had developed a ‘nervous melancholy’ that had ‘degenerated into mania’ and resulted in suicide.
What Pinel regarded as an unnecessary tragedy due to gross mismanagement seems to have haunted him.
It led him to seek employment at one of the best-known private sanatoria for the treatment of insanity in Paris.
He remained there for five years prior to the Revolution, gathering observations on insanity and beginning to formulate his views on its nature and treatment.

Pinel was an Ideologue, a disciple of the abbé de Condillac.
He was also a clinician who believed that medical truth was derived from clinical experience.
Hippocrates was his model.

During the 1780s, Pinel was invited to join the salon of Madame Helvétius.
He was in sympathy with the French Revolution.
After the revolution, friends he had met at Madame Helvétius’ salon came to power.
In August 1793 Pinel was appointed "physician of the infirmeries" at Bicêtre Hospital.
At the time it housed about four thousand imprisoned men—criminals, petty offenders, syphilitics, pensioners and about two hundred mental patients.
Pinel’s patrons hoped that his appointment would lead to therapeutic initiatives.
His experience at the private sanatoria made him a good candidate for the job.
Pinel was born in Jonquières, the South of France, in the modern department of Tarn. He was the son and nephew of physicians. After receiving a degree from the faculty of medicine in Toulouse, he studied an additional four years at the Faculty of Medicine of Montpellier. He arrived in Paris in 1778.
He spent fifteen years earning his living as a writer, translator, and editor because the restrictive regulations of the old regime prevented him from practicing medicine in Paris. The faculty did not recognize a degree from a provincial university like Toulouse. He failed twice in a competition which would have awarded him funds to continue his studies. In the second competition, the jury stressed his ‘painful’ mediocrity in all areas of medical knowledge, an assessment seemingly so grossly incompatible with his later intellectual accomplishments that political motives have been suggested. Discouraged, Pinel considered emigrating to America. In 1784 he became editor of the medical journal the Gazette de santé, a four-page weekly. He was also known among natural scientists as a regular contributor to the Journal de physique. He studied mathematics, translated medical works into French, and undertook botanical expeditions.
At about this time he began to develop an intense interest in the study of mental illness. The incentive was a personal one. A friend had developed a ‘nervous melancholy’ that had ‘degenerated into mania’ and resulted in suicide. What Pinel regarded as an unnecessary tragedy due to gross mismanagement seems to have haunted him. It led him to seek employment at one of the best-known private sanatoria for the treatment of insanity in Paris. He remained there for five years prior to the Revolution, gathering observations on insanity and beginning to formulate his views on its nature and treatment.
Pinel was an Ideologue, a disciple of the abbé de Condillac. He was also a clinician who believed that medical truth was derived from clinical experience. Hippocrates was his model.
During the 1780s, Pinel was invited to join the salon of Madame Helvétius. He was in sympathy with the French Revolution. After the revolution, friends he had met at Madame Helvétius’ salon came to power. In August 1793 Pinel was appointed "physician of the infirmeries" at Bicêtre Hospital. At the time it housed about four thousand imprisoned men—criminals, petty offenders, syphilitics, pensioners and about two hundred mental patients. Pinel’s patrons hoped that his appointment would lead to therapeutic initiatives. His experience at the private sanatoria made him a good candidate for the job.
Philippe Pinel