Polin succeeded ambassador Antoine de Rincon (1538–1541) in Constantinople.
In early 1542, Polin successfully negotiated the details of a Franco-Ottoman alliance for the Italian War of 1542–1546, with the Ottoman Empire promising to send 27,500 troops against the territories of the Spanish king Ferdinand, as well as 110 galleys against Charles, while France promised to attack Flanders, harass the coasts of Spain with a naval force, and send 40 galleys to assist the Turks for operations in the Levant.
Polin tried to convince Venice to join the alliance, but in vain.

The execution of the alliance would most notably lead to the Franco-Ottoman Siege of Nice in 1543.
In July 1543, Polin sailed on board the Ottoman fleet of Barbarossa to the Île Saint-Honorat in the Lérins Islands off Cannes on 5 July 1543, only to find very little ready for the offensive on the French side.
Polin went to see king Francis I of France to obtain troops, which led to the Siege of Nice in August 1543.
Polin supervised the wintering of the Ottomans at Toulon.

Then, in 1544, five French galleys under Polin, including the superb Réale, accompanied Barbarossa's fleet, on a diplomatic mission to Suleiman.
The French fleet accompanied Barbarossa during his attacks on the west coast of Italy on the way to Constantinople, as he laid waste to the cities of Porto Ercole, Giglio, Talamona, Lipari and took about 6,000 captives, but separated in Sicily from Barbarossa's fleet to continue alone to the Ottoman capital.
Jerôme Maurand, a priest of Antibes who accompanied Polin and the Ottoman fleet in 1544, wrote a detailed account in Itinéraire d'Antibes à Constantinople.
They arrived in Constantinople on 10 August 1544 to meet with Suleiman and give him an account of the campaign.
Polin was back to Toulon on 2 October 1544.
Polin succeeded ambassador Antoine de Rincon (1538–1541) in Constantinople. In early 1542, Polin successfully negotiated the details of a Franco-Ottoman alliance for the Italian War of 1542–1546, with the Ottoman Empire promising to send 27,500 troops against the territories of the Spanish king Ferdinand, as well as 110 galleys against Charles, while France promised to attack Flanders, harass the coasts of Spain with a naval force, and send 40 galleys to assist the Turks for operations in the Levant. Polin tried to convince Venice to join the alliance, but in vain.
The execution of the alliance would most notably lead to the Franco-Ottoman Siege of Nice in 1543. In July 1543, Polin sailed on board the Ottoman fleet of Barbarossa to the Île Saint-Honorat in the Lérins Islands off Cannes on 5 July 1543, only to find very little ready for the offensive on the French side. Polin went to see king Francis I of France to obtain troops, which led to the Siege of Nice in August 1543. Polin supervised the wintering of the Ottomans at Toulon.
Then, in 1544, five French galleys under Polin, including the superb Réale, accompanied Barbarossa's fleet, on a diplomatic mission to Suleiman. The French fleet accompanied Barbarossa during his attacks on the west coast of Italy on the way to Constantinople, as he laid waste to the cities of Porto Ercole, Giglio, Talamona, Lipari and took about 6,000 captives, but separated in Sicily from Barbarossa's fleet to continue alone to the Ottoman capital. Jerôme Maurand, a priest of Antibes who accompanied Polin and the Ottoman fleet in 1544, wrote a detailed account in Itinéraire d'Antibes à Constantinople. They arrived in Constantinople on 10 August 1544 to meet with Suleiman and give him an account of the campaign. Polin was back to Toulon on 2 October 1544.
Antoine Escalin des Aimars