Lufkin is home to Lufkin Industries, which manufactures and services oil field equipment and power transmission equipment, and supplies of creosote-treated utility poles.
It is also home to the Atkinson Candy Company, the creator of the Chick-O-Stick, and Brookshire Brothers, a chain of grocery stores in Texas and Louisiana.
Lufkin received Texas's first biomass power plant in late 2009.
Aspen Power is building the power plant.

Some of the city's major employers include:
Angelina College, community college with enrollment of 5,000
Atkinson Candy Company, founded and headquartered in Lufkin, makers of Chick-O-Stick
Brookshire Brothers, a regional grocery company founded and headquartered in Lufkin
Lufkin Industries, founded and headquartered in Lufkin, oil pumping and power transmission equipment manufacturer
Lufkin Independent School District
Pilgrim's, poultry processor that employs more than 1,500 people
Stephen F. Austin State University, state university (located in Nacogdoches; some employees reside in Lufkin)
Temple-Inland is Fortune 500 company that produces paper, wood, and other related products.
Headquartered in Diboll, 15 miles (24 km) south of Lufkin, it has employment in Lufkin, as well.
Temple-Inland was sold to International Paper.

According to the city's 2019 Comprehensive Annual Financial Report, the top employers in the city are:
Lufkin is home to Lufkin Industries, which manufactures and services oil field equipment and power transmission equipment, and supplies of creosote-treated utility poles. It is also home to the Atkinson Candy Company, the creator of the Chick-O-Stick, and Brookshire Brothers, a chain of grocery stores in Texas and Louisiana. Lufkin received Texas's first biomass power plant in late 2009. Aspen Power is building the power plant.
Some of the city's major employers include:
Angelina College, community college with enrollment of 5,000
Atkinson Candy Company, founded and headquartered in Lufkin, makers of Chick-O-Stick
Brookshire Brothers, a regional grocery company founded and headquartered in Lufkin
Lufkin Industries, founded and headquartered in Lufkin, oil pumping and power transmission equipment manufacturer
Lufkin Independent School District
Pilgrim's, poultry processor that employs more than 1,500 people
Stephen F. Austin State University, state university (located in Nacogdoches; some employees reside in Lufkin)
Temple-Inland is Fortune 500 company that produces paper, wood, and other related products. Headquartered in Diboll, 15 miles (24 km) south of Lufkin, it has employment in Lufkin, as well. Temple-Inland was sold to International Paper.
According to the city's 2019 Comprehensive Annual Financial Report, the top employers in the city are:
Lufkin, Texas