She has acted in the movies, Kissing Jessica Stein, Mo' Money, Garden State, Down, Queer Duck: The Movie, Legally Blonde 2: Red, White and Blonde, and A Dirty Shame and was the voice of the Water Cooler in Robots.

In addition to cameoing on the television show Curb Your Enthusiasm, she has appeared in many series, including Difficult People, Strangers with Candy, Hope and Faith, Ed, Starved, Cosby, 30 Rock, One Life to Live and was the voice of Dilmom on Dilbert.

Hoffman provided the voice of "Mary Phillips, the Talk Radio host", in the video game Grand Theft Auto: San Andreas.
Despite her frequent stage banter on her dislike of children, Hoffman did a surprising turn as the voices of the Gate to Fairy-tale Land and the Witch's Magic Wand in the Dora the Explorer movie, Dora's Fairytale Adventure.
She has also been a frequent guest on Late Night with Conan O'Brien.

In 2007 she was featured in the film Making Trouble, a tribute to female Jewish comedians, produced by the Jewish Women's Archive.
In 2011, Hoffman appeared as a cameo in The Sitter as Mrs. Sapperstein.
In 2012, she has had a recurring role in The New Normal.
She appeared in a cameo role in the Oscar-winning movie Birdman in 2014.

In 2017, she starred in the first season of the FX series entitled Feud: Bette and Joan in the role of Joan Crawford's housekeeper, Mamacita, for which she was nominated for the Primetime Emmy Award for Outstanding Supporting Actress in a Limited Series or Movie.
She has acted in the movies, Kissing Jessica Stein, Mo' Money, Garden State, Down, Queer Duck: The Movie, Legally Blonde 2: Red, White and Blonde, and A Dirty Shame and was the voice of the Water Cooler in Robots.
In addition to cameoing on the television show Curb Your Enthusiasm, she has appeared in many series, including Difficult People, Strangers with Candy, Hope and Faith, Ed, Starved, Cosby, 30 Rock, One Life to Live and was the voice of Dilmom on Dilbert.
Hoffman provided the voice of "Mary Phillips, the Talk Radio host", in the video game Grand Theft Auto: San Andreas. Despite her frequent stage banter on her dislike of children, Hoffman did a surprising turn as the voices of the Gate to Fairy-tale Land and the Witch's Magic Wand in the Dora the Explorer movie, Dora's Fairytale Adventure. She has also been a frequent guest on Late Night with Conan O'Brien.
In 2007 she was featured in the film Making Trouble, a tribute to female Jewish comedians, produced by the Jewish Women's Archive. In 2011, Hoffman appeared as a cameo in The Sitter as Mrs. Sapperstein. In 2012, she has had a recurring role in The New Normal. She appeared in a cameo role in the Oscar-winning movie Birdman in 2014.
In 2017, she starred in the first season of the FX series entitled Feud: Bette and Joan in the role of Joan Crawford's housekeeper, Mamacita, for which she was nominated for the Primetime Emmy Award for Outstanding Supporting Actress in a Limited Series or Movie.
Jackie Hoffman