Highway 103 begins at the intersection of Lakeview Drive as Marina Road in Clarksville near the Spadra Creek Use Area along the Arkansas River.
The route runs east then turns north to cross Interstate 40 (I-40) at exit 58.
Now entering the central part of the city, Highway 103 becomes Rogers Avenue and has an intersection with Highway 123 before meeting US Highway 64 in downtown Clarksville.
Now forming a 0.42 miles (0.68 km) concurrency westbound with US 64, the highways pass the Dunlap House and Johnson County Courthouse, both listed on the National Register of Historic Places (NRHP).
The concurrency ends when Highway 103 turns north and becomes College Avenue.
Highway 103 passes the historic First Presbyterian Church before entering the University of the Ozarks campus, with the majority of the campus buildings including the historic Clarksville National Guard Armory and Raymond Munger Memorial Chapel located on the west side of the highway.
Following the university, Highway 103 exits Clarksville and heads northwest to Harmony through sparsely populated forested land.

Harmony brings an intersection with Highway 164 near the Harmony Presbyterian Church before turning north and entering the Ozark National Forest, administrated by the United States Forest Service.
The highway winds slowly through the dense forest, including hairpin turns, to an intersection with Highway 215, where the highway terminates.
Highway 103 begins at the intersection of Lakeview Drive as Marina Road in Clarksville near the Spadra Creek Use Area along the Arkansas River. The route runs east then turns north to cross Interstate 40 (I-40) at exit 58. Now entering the central part of the city, Highway 103 becomes Rogers Avenue and has an intersection with Highway 123 before meeting US Highway 64 in downtown Clarksville. Now forming a 0.42 miles (0.68 km) concurrency westbound with US 64, the highways pass the Dunlap House and Johnson County Courthouse, both listed on the National Register of Historic Places (NRHP). The concurrency ends when Highway 103 turns north and becomes College Avenue. Highway 103 passes the historic First Presbyterian Church before entering the University of the Ozarks campus, with the majority of the campus buildings including the historic Clarksville National Guard Armory and Raymond Munger Memorial Chapel located on the west side of the highway. Following the university, Highway 103 exits Clarksville and heads northwest to Harmony through sparsely populated forested land.
Harmony brings an intersection with Highway 164 near the Harmony Presbyterian Church before turning north and entering the Ozark National Forest, administrated by the United States Forest Service. The highway winds slowly through the dense forest, including hairpin turns, to an intersection with Highway 215, where the highway terminates.
Arkansas Highway 103