Despite being invited to the NFL Scouting Combine, Hoyer was not selected in the 2009 NFL Draft.
 He signed immediately after the Draft with the New England Patriots.

Hoyer debuted in the Patriots' preseason game against the Cincinnati Bengals, completing 11-of-19 passes for 112 yards.
In the preseason finale against the New York Giants, he played at quarterback the entire game, leading the team on a comeback after trailing 21–0 in the first quarter to a 38–27 win, completing 18-of-25 passes for 242 yards, one touchdown, and no interceptions.

Hoyer finished the preseason 29–of–44 for 354 yards, including one touchdown, with a 98.1 passer rating.
Of the four quarterbacks behind Tom Brady during training camp, the Patriots released Matt Gutierrez, Kevin O'Connell, and Andrew Walter, leaving him as Brady's only backup when the Patriots made their final roster cuts on September 5.

Hoyer made his NFL debut on October 18, in the second half of a game against the Tennessee Titans.
On his first drive, he was 5-for-5 for 35 yards, concluding it with a 1-yard rushing touchdown, which set a franchise record for points scored in the Patriots' 59–0 win.
In the regular season finale, against the Houston Texans, he appeared in the game and finished 8-of-12 for 71 passing yards.
Despite being invited to the NFL Scouting Combine, Hoyer was not selected in the 2009 NFL Draft.  He signed immediately after the Draft with the New England Patriots.
Hoyer debuted in the Patriots' preseason game against the Cincinnati Bengals, completing 11-of-19 passes for 112 yards. In the preseason finale against the New York Giants, he played at quarterback the entire game, leading the team on a comeback after trailing 21–0 in the first quarter to a 38–27 win, completing 18-of-25 passes for 242 yards, one touchdown, and no interceptions.
Hoyer finished the preseason 29–of–44 for 354 yards, including one touchdown, with a 98.1 passer rating. Of the four quarterbacks behind Tom Brady during training camp, the Patriots released Matt Gutierrez, Kevin O'Connell, and Andrew Walter, leaving him as Brady's only backup when the Patriots made their final roster cuts on September 5.
Hoyer made his NFL debut on October 18, in the second half of a game against the Tennessee Titans. On his first drive, he was 5-for-5 for 35 yards, concluding it with a 1-yard rushing touchdown, which set a franchise record for points scored in the Patriots' 59–0 win. In the regular season finale, against the Houston Texans, he appeared in the game and finished 8-of-12 for 71 passing yards.
Brian Hoyer