According to some ancient writers, Caranus, the legendary founder of the Argead Dynasty (whose most famous member was Alexander the Great), established the city of Edessa and made it the first capital of ancient Macedon, and later Argead rulers moved Macedon's capital to Aegae and eventually Pella.
Archaeological remains have been discovered on the site of ancient Edessa, just below the modern city (40°47'48.48"N 22° 3'26.24"E).
The walls and many buildings have been unearthed so far.
A colonnade with inscription in Greek dates from Roman times.
The city achieved certain prominence in the first centuries AD, being located on the Via Egnatia.
From 27 BC to 268 AD it had its own mint.
The Orthodox Christian Saint Vassa and her three children were put to death here in the 3rd century AD.

Little is known about the fate of the city after 500 AD, but we know that its Greek bishop, Isidoros, participated in the Ecumenical Council of 692.

The city disappears from the sources thereafter, and re-emerges only in the 11th century, in the account of the Bulgarian wars of Emperor Basil II by the chronicler John Skylitzes, with the Slavic name Vodena (τὰ Βοδηνά in Greek).
The Bulgarian historian Vasil Zlatarski hypothesized that it was Vodena, and not Vidin on the Danube, that was a base of the Cometopuli in their revolt against Byzantium.

Due to its strategic location, controlling the Via Egnatia as it enters the Pindus mountains, the town was much fought over in the subsequent centuries: the Normans under Bohemond I captured it briefly in 1083, but were eventually repelled by the forces of Emperor Alexios I Komnenos.
The Nicaean emperor John III Vatatzes captured in 1253, while in the mid-14th century its possession was disputed between the Byzantines and the Serbs under Stephen Dushan, with the latter securing its possession in January 1351.
The city was for some time under control of Radoslav Hlapen, who gave it as dowry to his son-in-law Nikola Bagaš probably around 1366/7.
The city remained in Bagaš's hands at least until 1385.
It fell to the Ottoman war leader Evrenos Bey in the late 14th century, along with the rest of Macedonia.

During the period of Ottoman rule, the Turkish and Muslim component of the town's population steadily increased.
From the 1860s onwards, the town was a flashpoint for clashes between Greeks and Bulgarians.

After almost 500 years of Ottoman rule, Edessa was annexed by Greece on 18 October 1912 during the First Balkan War, following the Hellenic Army's military victory against the Ottomans in the battle of Sarantaporo.
At that time, Edessa was already well on its way to becoming a major industrial center in Macedonia.
Four large textile factories with the Hemp Factory  being the biggest, employing the abundant waterfalls as a source of energy.
Prior to World War I, in addition to Greeks, the region of Edessa was also populated by Turks, Bulgarians, Pomaks and Vlachs, but during the population exchange between Greece and Turkey most of the Turks and Pomaks living in Edessa were transferred to Turkey.
Large numbers of Greek refugees from Asia Minor were settled in the area in 1923.
The population swelled from 9,441 to 13,115 in the 1920s.
A large segment of the population specialized in silk production, allowing Edessa to enjoy a high standard of living in the interwar period (1922–1940).

The town suffered during the last days of German occupation of Greece in 1944.
As a retaliation for the shooting of one soldier by resistance fighters, the Nazis set Edessa on fire.
Half of the city, including the Cathedral and the First Primary School, was destroyed and thousands of people were left homeless.

During the Greek Civil War (1946-1949) Edessa was twice attacked in 1948 by the Democratic Army of Greece (DSE), under the control of the Communist Party of Greece.
The Slavic-Macedonian National Liberation Front (SNOF), later simply the National Liberation Front (NOF) was heavily established in the area, with eleven Slav Macedonian partisan units operating in the mountains around the city.
When the NOF merged with
According to some ancient writers, Caranus, the legendary founder of the Argead Dynasty (whose most famous member was Alexander the Great), established the city of Edessa and made it the first capital of ancient Macedon, and later Argead rulers moved Macedon's capital to Aegae and eventually Pella. Archaeological remains have been discovered on the site of ancient Edessa, just below the modern city (40°47'48.48"N 22° 3'26.24"E). The walls and many buildings have been unearthed so far. A colonnade with inscription in Greek dates from Roman times. The city achieved certain prominence in the first centuries AD, being located on the Via Egnatia. From 27 BC to 268 AD it had its own mint. The Orthodox Christian Saint Vassa and her three children were put to death here in the 3rd century AD. 
Little is known about the fate of the city after 500 AD, but we know that its Greek bishop, Isidoros, participated in the Ecumenical Council of 692.
The city disappears from the sources thereafter, and re-emerges only in the 11th century, in the account of the Bulgarian wars of Emperor Basil II by the chronicler John Skylitzes, with the Slavic name Vodena (τὰ Βοδηνά in Greek). The Bulgarian historian Vasil Zlatarski hypothesized that it was Vodena, and not Vidin on the Danube, that was a base of the Cometopuli in their revolt against Byzantium.
Due to its strategic location, controlling the Via Egnatia as it enters the Pindus mountains, the town was much fought over in the subsequent centuries: the Normans under Bohemond I captured it briefly in 1083, but were eventually repelled by the forces of Emperor Alexios I Komnenos. The Nicaean emperor John III Vatatzes captured in 1253, while in the mid-14th century its possession was disputed between the Byzantines and the Serbs under Stephen Dushan, with the latter securing its possession in January 1351. The city was for some time under control of Radoslav Hlapen, who gave it as dowry to his son-in-law Nikola Bagaš probably around 1366/7. The city remained in Bagaš's hands at least until 1385. It fell to the Ottoman war leader Evrenos Bey in the late 14th century, along with the rest of Macedonia.
During the period of Ottoman rule, the Turkish and Muslim component of the town's population steadily increased. From the 1860s onwards, the town was a flashpoint for clashes between Greeks and Bulgarians.
After almost 500 years of Ottoman rule, Edessa was annexed by Greece on 18 October 1912 during the First Balkan War, following the Hellenic Army's military victory against the Ottomans in the battle of Sarantaporo. At that time, Edessa was already well on its way to becoming a major industrial center in Macedonia. Four large textile factories with the Hemp Factory  being the biggest, employing the abundant waterfalls as a source of energy. Prior to World War I, in addition to Greeks, the region of Edessa was also populated by Turks, Bulgarians, Pomaks and Vlachs, but during the population exchange between Greece and Turkey most of the Turks and Pomaks living in Edessa were transferred to Turkey. Large numbers of Greek refugees from Asia Minor were settled in the area in 1923. The population swelled from 9,441 to 13,115 in the 1920s. A large segment of the population specialized in silk production, allowing Edessa to enjoy a high standard of living in the interwar period (1922–1940).
The town suffered during the last days of German occupation of Greece in 1944. As a retaliation for the shooting of one soldier by resistance fighters, the Nazis set Edessa on fire. Half of the city, including the Cathedral and the First Primary School, was destroyed and thousands of people were left homeless.
During the Greek Civil War (1946-1949) Edessa was twice attacked in 1948 by the Democratic Army of Greece (DSE), under the control of the Communist Party of Greece. The Slavic-Macedonian National Liberation Front (SNOF), later simply the National Liberation Front (NOF) was heavily established in the area, with eleven Slav Macedonian partisan units operating in the mountains around the city. When the NOF merged with
Edessa, Greece