On July 25, 2016, the Astros purchased Bregman's contract from the Grizzlies, adding him to their 25-man roster.
He made his major league debut at third base against the New York Yankees that same day.
He was the first position player from the 2015 Draft to debut in the Major Leagues.
 After he was hitless in his first 17 major league at bats through five games, the Astros moved him up to second in the batting order, to get him better pitches and demonstrate their confidence in him.

Bregman recorded his first major league hit on July 31 against the Detroit Tigers, with a single into center field.
His first home run came at home on August 16, tying the game against the Cardinals in the first inning with a two-run home run to right field at Minute Maid Park.
 For the 2016 season, he batted .264/.313/.478 with 8 home runs and 34 RBIs in 49 games.
His slugging percentage was the seventh-best of any Astros rookie all-time.
With 2015 AL Rookie of the Year Carlos Correa at shortstop, Bregman played 40 games at third base and 4 at shortstop.
On July 25, 2016, the Astros purchased Bregman's contract from the Grizzlies, adding him to their 25-man roster. He made his major league debut at third base against the New York Yankees that same day. He was the first position player from the 2015 Draft to debut in the Major Leagues.  After he was hitless in his first 17 major league at bats through five games, the Astros moved him up to second in the batting order, to get him better pitches and demonstrate their confidence in him.
Bregman recorded his first major league hit on July 31 against the Detroit Tigers, with a single into center field. His first home run came at home on August 16, tying the game against the Cardinals in the first inning with a two-run home run to right field at Minute Maid Park.  For the 2016 season, he batted .264/.313/.478 with 8 home runs and 34 RBIs in 49 games. His slugging percentage was the seventh-best of any Astros rookie all-time. With 2015 AL Rookie of the Year Carlos Correa at shortstop, Bregman played 40 games at third base and 4 at shortstop.
Alex Bregman