Pine Creek's source is in Potter County, 5 miles (8 km) southeast of Ulysses.
It flows southeast 16 miles (26 km) to Galeton, where it receives its first major tributary, the West Branch Pine Creek.
It then flows east 12 miles (19 km) to Tioga County and the village of Ansonia.
Here it receives its second major tributary, Marsh Creek, and turns south again for 16 miles (26 km).
This stretch is the start of the Pine Creek Gorge, which is about 1,000 feet (300 m) deep in places.

At the village of Blackwell, Pine Creek receives its third major tributary, Babb Creek.
It continues southwest 14 miles (23 km) and enters Lycoming County, where it turns southeast for 28 miles (45 km) to its mouth.
At Waterville it receives its fourth major tributary, Little Pine Creek.
Pine Creek continues south and forms part of the border between Lycoming and Clinton counties.

Its confluence with the West Branch Susquehanna River is at this border, between the boroughs of Avis (in Clinton County, to the west) and Jersey Shore (in Lycoming County, to the east).

The elevation at the source of Pine Creek is 2,420 feet (740 m), while the mouth is at an elevation of 520 feet (160 m).
The difference in elevation—1,900 feet (580 m)—divided by the length of the creek—86.5 miles (139.2 km)—gives an average drop or relief ratio of 22.0 ft/mi (4.2 m/km ).
The meander ratio is 1.08, so the creek is fairly straight in its bed.
Pine Creek's source is in Potter County, 5 miles (8 km) southeast of Ulysses. It flows southeast 16 miles (26 km) to Galeton, where it receives its first major tributary, the West Branch Pine Creek. It then flows east 12 miles (19 km) to Tioga County and the village of Ansonia. Here it receives its second major tributary, Marsh Creek, and turns south again for 16 miles (26 km). This stretch is the start of the Pine Creek Gorge, which is about 1,000 feet (300 m) deep in places.
At the village of Blackwell, Pine Creek receives its third major tributary, Babb Creek. It continues southwest 14 miles (23 km) and enters Lycoming County, where it turns southeast for 28 miles (45 km) to its mouth. At Waterville it receives its fourth major tributary, Little Pine Creek. Pine Creek continues south and forms part of the border between Lycoming and Clinton counties.
Its confluence with the West Branch Susquehanna River is at this border, between the boroughs of Avis (in Clinton County, to the west) and Jersey Shore (in Lycoming County, to the east).
The elevation at the source of Pine Creek is 2,420 feet (740 m), while the mouth is at an elevation of 520 feet (160 m). The difference in elevation—1,900 feet (580 m)—divided by the length of the creek—86.5 miles (139.2 km)—gives an average drop or relief ratio of 22.0 ft/mi (4.2 m/km ). The meander ratio is 1.08, so the creek is fairly straight in its bed.
Pine Creek (Pennsylvania)