Later in the year of 2003, Murray won the main role of Lucas Scott in the successful WB television series One Tree Hill.
The series quickly became the channel's biggest hit with over 4.50 million viewers on the first season's finale.
The series was The WB's most successful and top rated television program when it first aired in 2003 and continued receiving top ratings for The CW.
The series also earned Murray numerous awards, including two Teen Choice Awards, and spawned a book series.
After Murray gained mainstream fame and media exposure, he also became a spokesperson for several high-profile deals.
He and his One Tree Hill co-stars were the official endorsers for MasterCard and K-Mart.
They endorsed Cingular Wireless and the Chevy Cobalt.

Following Murray's starring role on One Tree Hill, he appeared on the cover of several mainstream magazines such as Rolling Stone and People.
That same year, he was voted as one of "TV's Sexiest Guys" in People magazine.
In 2004, Murray starred in the romantic comedy A Cinderella Story with Hilary Duff.
Though the reviews were mostly negative, the film went on to become a moderate box office success, earning $70.1 million worldwide.
The film led to 2005 Teen Choice Awards wins in several categories.
Later that year, Murray appeared on the cover of Teen People magazine.

In 2005, Murray starred in House of Wax.
The film grossed $12 million in its first day.
Though most film critics gave the film negative reviews, House of Wax earned over $70 million worldwide.
The film led to Murray receiving the 2005 Teen Choice Awards win category for "Choice Movie Actor: Action/Adventure/Thriller".
He featured briefly in the Iraq War drama Home of the Brave alongside Samuel L. Jackson and Jessica Biel in 2006.
In May 2009, The CW announced Murray would not be returning to One Tree Hill for its seventh season.
A video of Murray was recorded in which he was telling fans that they did not want him back because they wanted to save money.
However, Mark Schwann said in an interview that he had been offered "great things" to return to the show.

In 2010, Murray played Alicia Keys's love interest in her music video for "Un-Thinkable (I'm Ready)".
Then he played Ethan McAllister in Lifetime's TV movie Lies in Plain Sight.
Murray also co-starred in Christmas Cupid with Ashley Benson and Christina Milian.
The film is an ABC Family Original Movie and is "about a comatose girl who visits her Christmas past, present, and future".

In 2011, The CW announced he would return for a guest appearance as Lucas Scott in the final season of One Tree Hill.
The episode aired on February 22, 2012.
In 2013, Murray appeared in Fruitvale Station, a film chronicling the last day of Oscar Grant, who was killed by a police officer at a BART station.
The film won two major awards at the 2013 Sundance Film Festival.

In August 2014, he was cast in a featured role as Agent Jack Thompson for Marvel's television series Agent Carter, and has returned for the second season.

On February 8, 2019, it was announced that Murray was cast in a recurring role as Edgar Evernever on The CW drama Riverdale.
He will appear opposite Torrey DeVitto in Hallmark's upcoming Christmas film Five Cards for Christmas (2019).
The film centers around Jessica (DeVitto), who sends Christmas cards to five people who have impacted her life and Murray will appear as the son of a recipient of one of Jessica's letters.
Later in the year of 2003, Murray won the main role of Lucas Scott in the successful WB television series One Tree Hill. The series quickly became the channel's biggest hit with over 4.50 million viewers on the first season's finale. The series was The WB's most successful and top rated television program when it first aired in 2003 and continued receiving top ratings for The CW. The series also earned Murray numerous awards, including two Teen Choice Awards, and spawned a book series. After Murray gained mainstream fame and media exposure, he also became a spokesperson for several high-profile deals. He and his One Tree Hill co-stars were the official endorsers for MasterCard and K-Mart. They endorsed Cingular Wireless and the Chevy Cobalt.
Following Murray's starring role on One Tree Hill, he appeared on the cover of several mainstream magazines such as Rolling Stone and People. That same year, he was voted as one of "TV's Sexiest Guys" in People magazine. In 2004, Murray starred in the romantic comedy A Cinderella Story with Hilary Duff. Though the reviews were mostly negative, the film went on to become a moderate box office success, earning $70.1 million worldwide. The film led to 2005 Teen Choice Awards wins in several categories. Later that year, Murray appeared on the cover of Teen People magazine.
In 2005, Murray starred in House of Wax. The film grossed $12 million in its first day. Though most film critics gave the film negative reviews, House of Wax earned over $70 million worldwide. The film led to Murray receiving the 2005 Teen Choice Awards win category for "Choice Movie Actor: Action/Adventure/Thriller". He featured briefly in the Iraq War drama Home of the Brave alongside Samuel L. Jackson and Jessica Biel in 2006. In May 2009, The CW announced Murray would not be returning to One Tree Hill for its seventh season. A video of Murray was recorded in which he was telling fans that they did not want him back because they wanted to save money. However, Mark Schwann said in an interview that he had been offered "great things" to return to the show.
In 2010, Murray played Alicia Keys's love interest in her music video for "Un-Thinkable (I'm Ready)". Then he played Ethan McAllister in Lifetime's TV movie Lies in Plain Sight. Murray also co-starred in Christmas Cupid with Ashley Benson and Christina Milian. The film is an ABC Family Original Movie and is "about a comatose girl who visits her Christmas past, present, and future".
In 2011, The CW announced he would return for a guest appearance as Lucas Scott in the final season of One Tree Hill. The episode aired on February 22, 2012. In 2013, Murray appeared in Fruitvale Station, a film chronicling the last day of Oscar Grant, who was killed by a police officer at a BART station. The film won two major awards at the 2013 Sundance Film Festival.
In August 2014, he was cast in a featured role as Agent Jack Thompson for Marvel's television series Agent Carter, and has returned for the second season.
On February 8, 2019, it was announced that Murray was cast in a recurring role as Edgar Evernever on The CW drama Riverdale. He will appear opposite Torrey DeVitto in Hallmark's upcoming Christmas film Five Cards for Christmas (2019). The film centers around Jessica (DeVitto), who sends Christmas cards to five people who have impacted her life and Murray will appear as the son of a recipient of one of Jessica's letters.
Chad Michael Murray