In the Wheatbelt, Great Northern Highway links small town sites with the surrounding rural farmland, occasionally passing by remnant patches of woodlands.

From the north-eastern edge of Perth, the highway travels north for three kilometres (2 mi) to Muchea.
At Muchea the road curves to the west to approach a roundabout interchange with both Brand Highway and Tonkin Highway.
Unlike other interchanges in the outskirts of Perth, Great Northern Highway is not free flowing with the interchange configured to have an overpass connecting the northern continuation of Great Northern Highway with Tonkin Highway to the south instead.
Traffic wanting to continue on Great Northern Highway need to turn right at the roundabout to continue northwards while southbound traffic needs to exit the main carriageway and turn left at the roundabout.
Brand Highway and National Route 1 continues to the west of the roundabout.
There is also a Road train assembly area in the southeast quadrant of the interchange.

 Great Northern Highway and National Highway 95 then continues north-east for 26 kilometres (16 mi).
It passes to the west of Lake Chittering, curves east to cross the Brockman River, and then back north to Bindoon.
Five kilometres (3 mi) further north, Bindoon–Moora Road branches off to the north-west, while the highway skirts east briefly then continues north, reaching New Norcia after 46 kilometres (29 mi).
The starting point of The Midlands Road is located at Walebing, 35 kilometres (22 mi) further north; from there, Great Northern Highway heads north-east for 18 kilometres (11 mi) to Bindi Bindi, north for 17 kilometres (11 mi) to Miling, then east for 33 kilometres (21 mi) to the northern end of Northam–Pithara Road, and shortly thereafter  Pithara.
From here, another 16 kilometres (10 mi) takes the road to Dalwallinu, and Wubin is 20 kilometres (12 mi) further north.
In the Wheatbelt, Great Northern Highway links small town sites with the surrounding rural farmland, occasionally passing by remnant patches of woodlands.
From the north-eastern edge of Perth, the highway travels north for three kilometres (2 mi) to Muchea. At Muchea the road curves to the west to approach a roundabout interchange with both Brand Highway and Tonkin Highway. Unlike other interchanges in the outskirts of Perth, Great Northern Highway is not free flowing with the interchange configured to have an overpass connecting the northern continuation of Great Northern Highway with Tonkin Highway to the south instead. Traffic wanting to continue on Great Northern Highway need to turn right at the roundabout to continue northwards while southbound traffic needs to exit the main carriageway and turn left at the roundabout. Brand Highway and National Route 1 continues to the west of the roundabout. There is also a Road train assembly area in the southeast quadrant of the interchange.
 Great Northern Highway and National Highway 95 then continues north-east for 26 kilometres (16 mi). It passes to the west of Lake Chittering, curves east to cross the Brockman River, and then back north to Bindoon. Five kilometres (3 mi) further north, Bindoon–Moora Road branches off to the north-west, while the highway skirts east briefly then continues north, reaching New Norcia after 46 kilometres (29 mi). The starting point of The Midlands Road is located at Walebing, 35 kilometres (22 mi) further north; from there, Great Northern Highway heads north-east for 18 kilometres (11 mi) to Bindi Bindi, north for 17 kilometres (11 mi) to Miling, then east for 33 kilometres (21 mi) to the northern end of Northam–Pithara Road, and shortly thereafter  Pithara. From here, another 16 kilometres (10 mi) takes the road to Dalwallinu, and Wubin is 20 kilometres (12 mi) further north.
Great Northern Highway