Highways
Interstate 72 passes approximately 12 miles (19 km) south of Quincy.
Its spur route, Interstate 172, passes just east of town.
In recent years, the Prairie Trails Shopping Complex has been a focal point for development in this area.
Illinois Route 104 (Broadway) is a main east–west artery from the Mississippi River bridges to Interstate 172.
Illinois Route 96 enters the city from the southeast and travels north (through the east side of Quincy) to U.S. Route 24.
Illinois Route 57 branches south from U.S. 24 downtown and passes Quincy's Civic Center on its way to Interstate 172 southeast of the city.
Illinois 96 also serves as the Great River Road, which follows the path of the Mississippi River.
Eastbound U.S. 24 crosses the Mississippi River from Missouri on the Quincy Memorial Bridge, while westbound traffic uses the newer Bayview Bridge.
Bayview bridge was constructed in 1986, but was not built as a four-lane bridge because of budget cuts, as the cable suspension made it unaffordable to build a four-lane bridge.
Other groups claimed that business in the downtown part of Quincy would decline if the Memorial bridge was shut down.

On the Missouri side, U.S. 61 carries the Avenue of the Saints, a four-lane highway connecting Saint Louis to Minneapolis–Saint Paul.
The Avenue of the Saints derives its name from Saint Louis and Saint Paul, Minnesota.

Quincy is at the center of four-lane highways in all directions:
• The Avenue of the Saints passes just five miles to the west and is four-lane from Canada to the Gulf of Mexico.

• Illinois Highway 172 is part of the newly designated Route 110/CKC (Chicago–Kansas City Expressway) which offers a less-congested alternative route to these popular Midwest destinations.

Air travel
The Quincy Regional Airport is to Quincy's east, about 5 miles (8.0 km) outside of the city limits.

SkyWest operates daily flights to Chicago, which is about 300 miles from Quincy.
It is the 425th busiest airport in America based on passenger counts.
Flight instruction, plane rentals and hangar space are also available at the Airport.
Longest Runway: 7,089 ft.
Width: 150 ft.

Amtrak service
Quincy is an Amtrak community with a railroad station on the north side of town.
 Two state-supported trains, the Illinois Zephyr and the Carl Sandburg link Quincy with Chicago, Amtrak's main hub, with connections to hundreds of cities across the country.
 The Illinois Zephyr departs in the morning and arrives in the evening, while the Carl Sandburg arrives mid-day and departs in the late afternoon.
Both make the same stops to Chicago's Union Station.

Freight rail service
Burlington Northern Santa Fe and Norfolk Southern offer multiple freight trains daily and Burlington Junction Rail Road offers short line service many sites and development districts.

River access
Quincy is home to the northernmost port on the Mississippi River for 12-month barge traffic.
The municipal barge dock currently serves multiple industries in the South Quincy Development District.
The Mid America Intermodal Port Commission is working to secure funding for an additional multimillion-dollar intermodal port facility.
Highways
Interstate 72 passes approximately 12 miles (19 km) south of Quincy. Its spur route, Interstate 172, passes just east of town. In recent years, the Prairie Trails Shopping Complex has been a focal point for development in this area. Illinois Route 104 (Broadway) is a main east–west artery from the Mississippi River bridges to Interstate 172. Illinois Route 96 enters the city from the southeast and travels north (through the east side of Quincy) to U.S. Route 24. Illinois Route 57 branches south from U.S. 24 downtown and passes Quincy's Civic Center on its way to Interstate 172 southeast of the city. Illinois 96 also serves as the Great River Road, which follows the path of the Mississippi River. Eastbound U.S. 24 crosses the Mississippi River from Missouri on the Quincy Memorial Bridge, while westbound traffic uses the newer Bayview Bridge. Bayview bridge was constructed in 1986, but was not built as a four-lane bridge because of budget cuts, as the cable suspension made it unaffordable to build a four-lane bridge. Other groups claimed that business in the downtown part of Quincy would decline if the Memorial bridge was shut down.
On the Missouri side, U.S. 61 carries the Avenue of the Saints, a four-lane highway connecting Saint Louis to Minneapolis–Saint Paul. The Avenue of the Saints derives its name from Saint Louis and Saint Paul, Minnesota.
Quincy is at the center of four-lane highways in all directions:
• The Avenue of the Saints passes just five miles to the west and is four-lane from Canada to the Gulf of Mexico.
• Illinois Highway 172 is part of the newly designated Route 110/CKC (Chicago–Kansas City Expressway) which offers a less-congested alternative route to these popular Midwest destinations.
Air travel
The Quincy Regional Airport is to Quincy's east, about 5 miles (8.0 km) outside of the city limits. 
SkyWest operates daily flights to Chicago, which is about 300 miles from Quincy. It is the 425th busiest airport in America based on passenger counts. Flight instruction, plane rentals and hangar space are also available at the Airport. Longest Runway: 7,089 ft. Width: 150 ft.
Amtrak service
Quincy is an Amtrak community with a railroad station on the north side of town.  Two state-supported trains, the Illinois Zephyr and the Carl Sandburg link Quincy with Chicago, Amtrak's main hub, with connections to hundreds of cities across the country.  The Illinois Zephyr departs in the morning and arrives in the evening, while the Carl Sandburg arrives mid-day and departs in the late afternoon. Both make the same stops to Chicago's Union Station.
Freight rail service
Burlington Northern Santa Fe and Norfolk Southern offer multiple freight trains daily and Burlington Junction Rail Road offers short line service many sites and development districts.
River access
Quincy is home to the northernmost port on the Mississippi River for 12-month barge traffic. The municipal barge dock currently serves multiple industries in the South Quincy Development District. The Mid America Intermodal Port Commission is working to secure funding for an additional multimillion-dollar intermodal port facility.
Quincy, Illinois