In 1859 a play based on the novel entitled The Black Agate, or, Old foes with new faces was performed at the Academy of Music in Philadelphia.
The play was written by Elizabeth Bowers, who also played the part of Hypatia.

A more notable adaptation of the novel to the stage was G. Stuart Ogilvie's Hypatia, which opened at the Haymarket Theatre in London on 2 January 1893.
It was produced by Herbert Beerbohm Tree.
Julia Neilson played the character of Hypatia, and her husband Fred Terry played Philammon.
The play featured an elaborate musical score written by the composer Hubert Parry.
Ogilvie's play introduced a scheming Jewish character called Issachar (played by Tree) in place of Kingsley's Miriam.
The portrayal of Issachar was relatively sympathetic, as Tree had great respect for the Jewish contribution to contemporary theatre.
Even The Jewish Chronicle noted that Issachar is "ambitious and able, he plots and counterplots but there is no suspicion or meanness in his nature" and concluded that he was the "least conventional and least offensive of recent stage Jews".
In 1859 a play based on the novel entitled The Black Agate, or, Old foes with new faces was performed at the Academy of Music in Philadelphia. The play was written by Elizabeth Bowers, who also played the part of Hypatia.
A more notable adaptation of the novel to the stage was G. Stuart Ogilvie's Hypatia, which opened at the Haymarket Theatre in London on 2 January 1893. It was produced by Herbert Beerbohm Tree. Julia Neilson played the character of Hypatia, and her husband Fred Terry played Philammon. The play featured an elaborate musical score written by the composer Hubert Parry. Ogilvie's play introduced a scheming Jewish character called Issachar (played by Tree) in place of Kingsley's Miriam. The portrayal of Issachar was relatively sympathetic, as Tree had great respect for the Jewish contribution to contemporary theatre. Even The Jewish Chronicle noted that Issachar is "ambitious and able, he plots and counterplots but there is no suspicion or meanness in his nature" and concluded that he was the "least conventional and least offensive of recent stage Jews".
Hypatia (novel)