The watershed of Spring Run has an area of 1.34 square miles (3.5 km²).
The stream is entirely within the United States Geological Survey quadrangle of Milton.
Its mouth is located at Watsontown.

In the early 1970s, approximately 71 acres (29 ha), or 8.56 percent of the watershed of Spring Run, was residential land.
Out of this, a total of 45.75 acres (18.51 ha) were suburban, 18.00 acres (7.28 ha) were mobile homes, and 7.35 acres (2.97 ha) were rural non-farm areas.
A total of 3.24 acres (1.31 ha), or 0.39 percent of the stream's watershed, was commercial land.

The designated use for Spring Run is aquatic life.
The stream is classified as a Warmwater Fishery.
The watershed of Spring Run has an area of 1.34 square miles (3.5 km²). The stream is entirely within the United States Geological Survey quadrangle of Milton. Its mouth is located at Watsontown.
In the early 1970s, approximately 71 acres (29 ha), or 8.56 percent of the watershed of Spring Run, was residential land. Out of this, a total of 45.75 acres (18.51 ha) were suburban, 18.00 acres (7.28 ha) were mobile homes, and 7.35 acres (2.97 ha) were rural non-farm areas. A total of 3.24 acres (1.31 ha), or 0.39 percent of the stream's watershed, was commercial land.
The designated use for Spring Run is aquatic life. The stream is classified as a Warmwater Fishery.
Spring Run (West Branch Susquehanna River tributary)