In 1925, the company Sociedade Estoril elaborated a project for a station along the margin of the civil parish of São Paulo.

The station was completed and inaugurated on 18 August 1928.

A new roof was built over the platforms in 1960, but on 28 May 1963 this collapsed while one train was loading and another was unloading.
 About 50 people were killed and many more injured.

In 1993, metro station Cais do Sodré metro station was opened to link the railway station, a project of Nuno Teotónio Pereira, who was contracted in 1998 to remodel the site.
He was brought back in 2000, in order to construct the river terminal along the northern margin of the Tagus.

On 4 August 1995, there was a proposal to classify the railway station by URBE.
A dispatch to begin the classification process was instituted on 20 OCtober 2004, by the vice-president of IPPAR, which was later amended on 24 August 2007 (to status of Imóvel de Interesse Público), and later, on 23 November 2011, Conselho Nacional de Cultura (National Council of Culture) proposed its classification as a Monumento de Interesse Público (Monument of Public Interest).
It was on 30 January 2012, when the project was descively classified and its area of protection designated (Announcement 1216/2012, Diário da República, Série 2, 15).
In 1925, the company Sociedade Estoril elaborated a project for a station along the margin of the civil parish of São Paulo.
The station was completed and inaugurated on 18 August 1928.
A new roof was built over the platforms in 1960, but on 28 May 1963 this collapsed while one train was loading and another was unloading.  About 50 people were killed and many more injured.
In 1993, metro station Cais do Sodré metro station was opened to link the railway station, a project of Nuno Teotónio Pereira, who was contracted in 1998 to remodel the site. He was brought back in 2000, in order to construct the river terminal along the northern margin of the Tagus.
On 4 August 1995, there was a proposal to classify the railway station by URBE. A dispatch to begin the classification process was instituted on 20 OCtober 2004, by the vice-president of IPPAR, which was later amended on 24 August 2007 (to status of Imóvel de Interesse Público), and later, on 23 November 2011, Conselho Nacional de Cultura (National Council of Culture) proposed its classification as a Monumento de Interesse Público (Monument of Public Interest). It was on 30 January 2012, when the project was descively classified and its area of protection designated (Announcement 1216/2012, Diário da República, Série 2, 15).
Cais do Sodré railway station