After completing his law degree, Neukom served as a clerk for Judge Theodore S. Turner of the King County Superior Court in Seattle in the years 1967–68.

By 1977, he had joined the Seattle law firm Shidler, McBroom, Gates & Lucas (later Preston Gates & Ellis).
Neukom's relationship with Microsoft began in 1978 when managing partner Bill Gates Sr.
asked him to advise his son's fledgling software business.
Neukom started doing legal work for Microsoft when the company had just 12 employees.
He would continue to be Microsoft's lead legal counsel for nearly 25 years.

Neukom joined Microsoft as an employee in 1985 and thereafter built its corporate law department from an initial staff of five to more than 600 attorneys and support personnel.
He became an Executive Vice President at Microsoft.
He spent 17 years as Microsoft's general counsel and chief legal officer, managing the company's legal, governmental affairs and philanthropic activities.

He was actively involved in legally defending Microsoft's intellectual property in several countries, most notably in Apple v. Microsoft.
He also was involved in defending Microsoft from a series of complex antitrust suits (i.e. United States v. Microsoft).
Neukom presided over Microsoft's defeat by the U.S. Department of Justice in a case that was referred to as the "trial of the century."
While at Microsoft, Neukom also directed the company's community affairs program, which initiated corporate giving programs including the Microsoft Giving Campaign, the Microsoft Matching Gifts Program, and the Microsoft Volunteer Program.
 In 2002 Neukom retired from Microsoft as Executive Vice President, Law & Corporate Affairs.

After Microsoft, Neukom returned to Preston Gates & Ellis as a partner in the firm's business law practice.
In January 2004 he was named chair of that firm.
 In 2007 Preston Gates & Ellis merged with Kirkpatrick and Lockhart of Pittsburgh to form the large law firm now named K&L Gates.
Neukom no longer is affiliated with the firm.

Neukom served as president of the American Bar Association for a one year term from August 2007 to August 2008.
After completing his law degree, Neukom served as a clerk for Judge Theodore S. Turner of the King County Superior Court in Seattle in the years 1967–68.
By 1977, he had joined the Seattle law firm Shidler, McBroom, Gates & Lucas (later Preston Gates & Ellis). Neukom's relationship with Microsoft began in 1978 when managing partner Bill Gates Sr. asked him to advise his son's fledgling software business. Neukom started doing legal work for Microsoft when the company had just 12 employees. He would continue to be Microsoft's lead legal counsel for nearly 25 years.
Neukom joined Microsoft as an employee in 1985 and thereafter built its corporate law department from an initial staff of five to more than 600 attorneys and support personnel. He became an Executive Vice President at Microsoft. He spent 17 years as Microsoft's general counsel and chief legal officer, managing the company's legal, governmental affairs and philanthropic activities.
He was actively involved in legally defending Microsoft's intellectual property in several countries, most notably in Apple v. Microsoft. He also was involved in defending Microsoft from a series of complex antitrust suits (i.e. United States v. Microsoft). Neukom presided over Microsoft's defeat by the U.S. Department of Justice in a case that was referred to as the "trial of the century." While at Microsoft, Neukom also directed the company's community affairs program, which initiated corporate giving programs including the Microsoft Giving Campaign, the Microsoft Matching Gifts Program, and the Microsoft Volunteer Program.  In 2002 Neukom retired from Microsoft as Executive Vice President, Law & Corporate Affairs.
After Microsoft, Neukom returned to Preston Gates & Ellis as a partner in the firm's business law practice. In January 2004 he was named chair of that firm.  In 2007 Preston Gates & Ellis merged with Kirkpatrick and Lockhart of Pittsburgh to form the large law firm now named K&L Gates. Neukom no longer is affiliated with the firm.
Neukom served as president of the American Bar Association for a one year term from August 2007 to August 2008.
Bill Neukom