Originally, there was probably a Roman bridge, and a street name sign indicates that it is the ancient route of the Rhine.

The current form of the street dates back at least to the end of the seventeenth century.
Until 1887, it was called rue Saint-Marcel, while the part near the Saône was called rue Musique des Anges.
The name "Saint-Marcel" was chosen after a former anchorite  and a former gate of the city.

At the time, the street provided access to two major climbs to leave Lyon to the north, the montée de la Grande Côte and the montée des Carmélites.
There were two monasteries located in the street: the Benedictines of the Desert since 1296, and the Grands Augustins between 1319 and 1509, but these monasteries have moved.
The Confraternity of Penitents of the Holy Crucifix was installed in the street in 1633, and, during the Ancien Régime, was the owner of the chapel rebuilt in 1643 which was demolished during the Reign of Terror and replaced by a house that currently overlooks the montée de la Grande Côte.

The street was eventually named with its current name after the deliberation of the municipal council on 26 April 1887.

In 1804, the first Jacquard loom was installed in the street.
Circa 1981, Radio Canut was housed at No.
24.
On 8 February 2005, the city of Lyon installed a plaque as tribute to Jewish children of the school who were deported and killed during the Second World War.
Among the famous inhabitants of the street, there are the painters Jacques Collet (1557) and Jean Montet (1785), and the designer Martin François (1887).
The father of artist Paul Chenavard was dyer in the rue Saint-Marcel.
Originally, there was probably a Roman bridge, and a street name sign indicates that it is the ancient route of the Rhine.
The current form of the street dates back at least to the end of the seventeenth century. Until 1887, it was called rue Saint-Marcel, while the part near the Saône was called rue Musique des Anges. The name "Saint-Marcel" was chosen after a former anchorite  and a former gate of the city.
At the time, the street provided access to two major climbs to leave Lyon to the north, the montée de la Grande Côte and the montée des Carmélites. There were two monasteries located in the street: the Benedictines of the Desert since 1296, and the Grands Augustins between 1319 and 1509, but these monasteries have moved. The Confraternity of Penitents of the Holy Crucifix was installed in the street in 1633, and, during the Ancien Régime, was the owner of the chapel rebuilt in 1643 which was demolished during the Reign of Terror and replaced by a house that currently overlooks the montée de la Grande Côte.
The street was eventually named with its current name after the deliberation of the municipal council on 26 April 1887.
In 1804, the first Jacquard loom was installed in the street. Circa 1981, Radio Canut was housed at No. 24. On 8 February 2005, the city of Lyon installed a plaque as tribute to Jewish children of the school who were deported and killed during the Second World War. Among the famous inhabitants of the street, there are the painters Jacques Collet (1557) and Jean Montet (1785), and the designer Martin François (1887). The father of artist Paul Chenavard was dyer in the rue Saint-Marcel.
Rue du Sergent Blandan