Thuso Nokwanda Mbedu was born and raised in Pelham, a borough of Pietermaritzburg, KwaZulu-Natal.
She was raised by her grandmother who was her legal guardian after the passing of both her parents at an early age.
When Mbedu was eighteen, she attended the University of Witwatersrand, where she studied Physical Theatre and Performing Arts Management, resulting her graduating with an honours.
In 2012, she attended the Stella Adler Studio of Acting in New York, USA.

In late 2014 she had a small role in the second season of the Mzansi Magic soapie isiBaya, before landing her role as journalism student and wild child Kitso on Scandal!.
She then had a guest role as Kheti on the second season of the SABC 2 teen drama series Snake Park.

After being jobless for six months, Thuso landed her first starring role in television in the Mzansi Magic teen drama series Is'thunzi, which premiered in October 2016.
In the series she played Winnie, a sassy go-getter who dreams of marrying a rich and famous rugby player only to have her dreams dashed when she is exiled to go live with her strict aunt in Bergville, KwaZulu-Natal.
While filming a rape scene for the show, she suffered from a panic attack.
In September 2017 she was nominated for an International Emmy award in the category Best Performance by an Actress for her role as Winnie in Is'Thunzi and was the only African to be nominated that year.
Thuso Nokwanda Mbedu was born and raised in Pelham, a borough of Pietermaritzburg, KwaZulu-Natal. She was raised by her grandmother who was her legal guardian after the passing of both her parents at an early age. When Mbedu was eighteen, she attended the University of Witwatersrand, where she studied Physical Theatre and Performing Arts Management, resulting her graduating with an honours. In 2012, she attended the Stella Adler Studio of Acting in New York, USA. 
In late 2014 she had a small role in the second season of the Mzansi Magic soapie isiBaya, before landing her role as journalism student and wild child Kitso on Scandal!. She then had a guest role as Kheti on the second season of the SABC 2 teen drama series Snake Park.
After being jobless for six months, Thuso landed her first starring role in television in the Mzansi Magic teen drama series Is'thunzi, which premiered in October 2016. In the series she played Winnie, a sassy go-getter who dreams of marrying a rich and famous rugby player only to have her dreams dashed when she is exiled to go live with her strict aunt in Bergville, KwaZulu-Natal. While filming a rape scene for the show, she suffered from a panic attack. In September 2017 she was nominated for an International Emmy award in the category Best Performance by an Actress for her role as Winnie in Is'Thunzi and was the only African to be nominated that year.
Thuso Mbedu