The 2008 season Seppi won his first Challenger title at Bergamo where he defeated Julien Benneteau in the final for the loss of 1 set in the tournament.
He made the quarter-finals of the indoor event in Rotterdam where he defeated Lleyton Hewitt in the process saving a match point.
Then he scored his biggest win over the then world number 2 Rafael Nadal before losing to Robin Söderling.
Seppi qualified for the semi-finals of the Hamburg Masters, this was the first time he reached that stage of the Masters Series events, he defeated Richard Gasquet, Juan Mónaco and Nicolas Kiefer in a match where he led 6–3, 5–3 before winning which included Seppi winning the last 4 games and went for 3 hours and 13 minutes in duration, before losing to Roger Federer in the semi-finals.

In 2009 Seppi made the semi finals in Belgrade and in Umag both on clay, while winning his second Challenger title in San Marino defeating countryman Potito Starace in the final.
Seppi found success at the challenger level in 2010 where he won his third challenger title at Kitzbühel accounting for Victor Crivoi in the final.
The 2008 season Seppi won his first Challenger title at Bergamo where he defeated Julien Benneteau in the final for the loss of 1 set in the tournament. He made the quarter-finals of the indoor event in Rotterdam where he defeated Lleyton Hewitt in the process saving a match point. Then he scored his biggest win over the then world number 2 Rafael Nadal before losing to Robin Söderling. Seppi qualified for the semi-finals of the Hamburg Masters, this was the first time he reached that stage of the Masters Series events, he defeated Richard Gasquet, Juan Mónaco and Nicolas Kiefer in a match where he led 6–3, 5–3 before winning which included Seppi winning the last 4 games and went for 3 hours and 13 minutes in duration, before losing to Roger Federer in the semi-finals.
In 2009 Seppi made the semi finals in Belgrade and in Umag both on clay, while winning his second Challenger title in San Marino defeating countryman Potito Starace in the final. Seppi found success at the challenger level in 2010 where he won his third challenger title at Kitzbühel accounting for Victor Crivoi in the final.
Andreas Seppi