In 2007, Klinghoffer played with Red Hot Chili Peppers on the final few legs of their Stadium Arcadium tour, playing additional guitar, backing vocals, and keyboard parts alongside the band.
His first show with the band took place on March 12, 2007 at the Cox Convention Center Arena in Oklahoma City.
This tour would ultimately be John Frusciante's last with the band, and Klinghoffer's first.
On May 8, 2009, amidst confusion as to whether Frusciante still remained within Red Hot Chili Peppers, Klinghoffer, Anthony Kiedis, Flea, Chad Smith, Ron Wood and Ivan Neville performed under the name The Insects at a MusiCares in honor of Kiedis's commitment to helping those struggling with addiction and recovery.

In 2009, the Chili Peppers ended a two-year hiatus, and were joined by Klinghoffer in the studio to begin work on their tenth album, I'm with You.
At the time, unbeknownst to the public, Frusciante had already quit the band earlier that year without announcing his departure.
In January 2010, Klinghoffer performed with the band for the first time as their lead guitarist at a MusiCares tribute event to Neil Young for a performance of Young's "A Man Needs a Maid."
It was later revealed he would permanently replace Frusciante as guitarist.
Klinghoffer was officially named the replacement for John Frusciante in early 2010.
Regarding his entry into the band, Klinghoffer notes, "I've always been attracted to the idea of a tight-knit unit, a band of family, a brotherhood.
Since my earliest memory, they always seemed like a band with a lot of love for each other."

In May 2010, Klinghoffer along with Flea performed the United States national anthem at a Lakers home playoff game during the NBA Western Conference Finals series against the Phoenix Suns.

After eleven months of writing and rehearsing, the Chili Peppers began recording a new album, I'm with You, on September 13, 2010.
Klinghoffer also sang, wrote music and played keyboards on the album.
Recording was completed on March 18, 2011 and the album was released on August 29, 2011.
The album's first single was "The Adventures of Rain Dance Maggie".

In 2011, Klinghoffer wrote and performed the original score for the documentary Bob and the Monster.
Klinghoffer also appears in the documentary, which is based on the life and career of musician and drug counselor Bob Forrest.
Klinghoffer was said to have recorded on at least one track on former Jane's Addiction bassist Eric Avery's second solo album, however LIFE.TIME.
did not include it.
On July 10, 2011, Klinghoffer appeared at the 2011 School of Rock's Rock the House Tour which also featured Keith Morris and Page Hamilton.
Klinghoffer joined the School of Rock kids on stage to perform Red Hot Chili Peppers songs "Dani California" and "Give It Away".
This was the first time he performed any of the Chili Peppers' songs live since officially joining the band as their guitarist.

In April 2012, Klinghoffer was inducted into the Rock and Roll Hall of Fame as a member of the Red Hot Chili Peppers.
At 32 years of age, Klinghoffer is the youngest artist ever inducted, surpassing Stevie Wonder, who was 38 when he was inducted.

In January 2015, Klinghoffer returned to the studio with the Chili Peppers to begin work on their eleventh studio album which would be produced by Gnarls Barkley's Danger Mouse.
Recording was put on hold the following month when bassist Flea suffered an injury during a skiing trip.
Production resumed in August 2015 and The Getaway was released on June 17, 2016 which was followed by an extensive world tour that concluded on October 2017.

Work on Klinghoffer's album To Be One With You was announced in September 2018, with plans to release it sometime in 2019.
However, the recording was delayed due to the Woolsey Fire.

On November 2, 2019, the band performed a charity event at the Silverlake Conservatory of Music in Los Angeles, CA.
 This would be the band's final show with Klinghoffer.

On December 15, 2019 it was announced via an Instagram post that Josh was “parting ways” with the band after ten years, and that John Fr
In 2007, Klinghoffer played with Red Hot Chili Peppers on the final few legs of their Stadium Arcadium tour, playing additional guitar, backing vocals, and keyboard parts alongside the band. His first show with the band took place on March 12, 2007 at the Cox Convention Center Arena in Oklahoma City. This tour would ultimately be John Frusciante's last with the band, and Klinghoffer's first. On May 8, 2009, amidst confusion as to whether Frusciante still remained within Red Hot Chili Peppers, Klinghoffer, Anthony Kiedis, Flea, Chad Smith, Ron Wood and Ivan Neville performed under the name The Insects at a MusiCares in honor of Kiedis's commitment to helping those struggling with addiction and recovery.
In 2009, the Chili Peppers ended a two-year hiatus, and were joined by Klinghoffer in the studio to begin work on their tenth album, I'm with You. At the time, unbeknownst to the public, Frusciante had already quit the band earlier that year without announcing his departure. In January 2010, Klinghoffer performed with the band for the first time as their lead guitarist at a MusiCares tribute event to Neil Young for a performance of Young's "A Man Needs a Maid." It was later revealed he would permanently replace Frusciante as guitarist. Klinghoffer was officially named the replacement for John Frusciante in early 2010. Regarding his entry into the band, Klinghoffer notes, "I've always been attracted to the idea of a tight-knit unit, a band of family, a brotherhood. Since my earliest memory, they always seemed like a band with a lot of love for each other."
In May 2010, Klinghoffer along with Flea performed the United States national anthem at a Lakers home playoff game during the NBA Western Conference Finals series against the Phoenix Suns.
After eleven months of writing and rehearsing, the Chili Peppers began recording a new album, I'm with You, on September 13, 2010. Klinghoffer also sang, wrote music and played keyboards on the album. Recording was completed on March 18, 2011 and the album was released on August 29, 2011. The album's first single was "The Adventures of Rain Dance Maggie".
In 2011, Klinghoffer wrote and performed the original score for the documentary Bob and the Monster. Klinghoffer also appears in the documentary, which is based on the life and career of musician and drug counselor Bob Forrest. Klinghoffer was said to have recorded on at least one track on former Jane's Addiction bassist Eric Avery's second solo album, however LIFE.TIME. did not include it. On July 10, 2011, Klinghoffer appeared at the 2011 School of Rock's Rock the House Tour which also featured Keith Morris and Page Hamilton. Klinghoffer joined the School of Rock kids on stage to perform Red Hot Chili Peppers songs "Dani California" and "Give It Away". This was the first time he performed any of the Chili Peppers' songs live since officially joining the band as their guitarist.
In April 2012, Klinghoffer was inducted into the Rock and Roll Hall of Fame as a member of the Red Hot Chili Peppers. At 32 years of age, Klinghoffer is the youngest artist ever inducted, surpassing Stevie Wonder, who was 38 when he was inducted.
In January 2015, Klinghoffer returned to the studio with the Chili Peppers to begin work on their eleventh studio album which would be produced by Gnarls Barkley's Danger Mouse. Recording was put on hold the following month when bassist Flea suffered an injury during a skiing trip. Production resumed in August 2015 and The Getaway was released on June 17, 2016 which was followed by an extensive world tour that concluded on October 2017.
Work on Klinghoffer's album To Be One With You was announced in September 2018, with plans to release it sometime in 2019. However, the recording was delayed due to the Woolsey Fire.
On November 2, 2019, the band performed a charity event at the Silverlake Conservatory of Music in Los Angeles, CA.  This would be the band's final show with Klinghoffer.
On December 15, 2019 it was announced via an Instagram post that Josh was “parting ways” with the band after ten years, and that John Fr
Josh Klinghoffer