Little made her debut for the Scotland women's national football team in February 2007 at the age of 16 in a match against Japan, coming in as a second-half substitute for Megan Sneddon.
National coach Anna Signeul had no hesitation in promoting Little into the senior team at 16: "Kim is an exceptional talent.
There's no limit to how far she can progress.
She has technique, speed and power, and she reads the game extremely well."
She scored her first international goal as Scotland lost to Russia in March 2008.

During her 50th cap, Little scored the game-opening goal in Scotland's 2–0 victory against rival England at the Cyprus Cup in March 2011.
It was only the second time Scotland had ever defeated their rivals, and was the first time since 1977 – 13 years before Little was born.

On 16 June 2012, Little scored Scotland's first hat trick during the team's 8–0 win against Israel.
In October 2012, she scored in both legs of Scotland's UEFA Women's Euro 2013 qualifying play-off against Spain.
In the second leg Verónica Boquete scored in injury time of extra time to make the score 3–2 to Spain and eliminate the Scots, who were left "utterly disconsolate" at missing out on qualification for their first ever final tournament.

In February 2013, Little scored Scotland's only goal during a friendly match against the United States in which the U.S. won 4–1.
During the 2013 Cyprus Cup, Little scored a goal and served an assist in Scotland's 4–4 draw against England during the group stage of the tournament.
She scored another goal in the 11th minute of the team's fifth place match against the Netherlands resulting in a 1–0 win for Scotland.

Little missed UEFA Women's Euro 2017 due to her serious injury.
After recovering from the injury, she helped Scotland qualify for the 2019 FIFA Women's World Cup, their first appearance in a world finals.
Little scored the only goal in a friendly against Brazil in April 2019.
At 2019 World Cup, she scored the opening goal of the 3–3 draw with Argentina.

In their first game after the World Cup, a Euro 2021 qualifying match with Cyprus, Little scored five goals in an 8–0 win for Scotland.
Little made her debut for the Scotland women's national football team in February 2007 at the age of 16 in a match against Japan, coming in as a second-half substitute for Megan Sneddon. National coach Anna Signeul had no hesitation in promoting Little into the senior team at 16: "Kim is an exceptional talent. There's no limit to how far she can progress. She has technique, speed and power, and she reads the game extremely well." She scored her first international goal as Scotland lost to Russia in March 2008.
During her 50th cap, Little scored the game-opening goal in Scotland's 2–0 victory against rival England at the Cyprus Cup in March 2011. It was only the second time Scotland had ever defeated their rivals, and was the first time since 1977 – 13 years before Little was born.
On 16 June 2012, Little scored Scotland's first hat trick during the team's 8–0 win against Israel. In October 2012, she scored in both legs of Scotland's UEFA Women's Euro 2013 qualifying play-off against Spain. In the second leg Verónica Boquete scored in injury time of extra time to make the score 3–2 to Spain and eliminate the Scots, who were left "utterly disconsolate" at missing out on qualification for their first ever final tournament.
In February 2013, Little scored Scotland's only goal during a friendly match against the United States in which the U.S. won 4–1. During the 2013 Cyprus Cup, Little scored a goal and served an assist in Scotland's 4–4 draw against England during the group stage of the tournament. She scored another goal in the 11th minute of the team's fifth place match against the Netherlands resulting in a 1–0 win for Scotland.
Little missed UEFA Women's Euro 2017 due to her serious injury. After recovering from the injury, she helped Scotland qualify for the 2019 FIFA Women's World Cup, their first appearance in a world finals. Little scored the only goal in a friendly against Brazil in April 2019. At 2019 World Cup, she scored the opening goal of the 3–3 draw with Argentina.
In their first game after the World Cup, a Euro 2021 qualifying match with Cyprus, Little scored five goals in an 8–0 win for Scotland.
Kim Little