Due to his family heritage, Dybala was eligible to play for Poland and Italy, but expressly stated that he feels Argentine and had always dreamed of playing for Argentina.
Dybala stated "I feel 100 percent Argentinian, I wouldn't be happy in a national team that didn't feel like mine, to hear an anthem that isn't my own, in colours that don't belong to me".

Dybala was called by the Argentina under-17 team to participate in the XVI Pan American Games, but ultimately did not take part in the competition.
On 19 July 2012, he received his first call-up for the under-20 team, but declined the invitation.

On 22 September 2015, Dybala was called for the first time for the Argentina senior team by manager Gerardo Martino, but his first appearance was on 13 October 2015, coming off the bench to replace Carlos Tevez in the 75th minute during a 2018 FIFA World Cup qualifying match against Paraguay.
In May 2016, he was omitted from Argentina's 23-man squad for the Copa América Centenario.
Although Juventus insisted that they would not release Dybala for the 2016 Summer Olympics in Rio de Janeiro, he was included in Martino's 35-man preliminary under-23 squad for the tournament on 24 May; he was not included in the final squad for the tournament, however.

On 1 September 2016, Dybala was sent off in the first half of a 1–0 home win over Uruguay in a 2018 World Cup qualifier for a second bookable offence.
On 13 June 2017, he set up a goal for Joaquín Correa in a 6–0 away friendly win over Singapore.

In May 2018, Dybala was named in Argentina's preliminary 35-man squad for the 2018 FIFA World Cup in Russia; later that month, he was included in Jorge Sampaoli's final 23-man squad for the tournament.
He made his World Cup debut in Argentina's second group match on 21 June, coming on as a second-half substitute for Enzo Pérez in the 68th minute of an eventual 3–0 defeat to Croatia.
This was his only appearance in the tournament, as Argentina were eliminated in the round of 16 on 30 June, following a 4–3 defeat to France.

Later that year, he scored his first senior international goal on 20 November, in a 2–0 friendly home win over Mexico.

In May 2019, Dybala was included in Argentina manager Lionel Scaloni's preliminary 40-man squad for the 2019 Copa América.
Later that month, he was included in the final 23-man squad for the tournament.
In Argentina's final group match against Qatar on 23 June, Dybala assisted Agüero's goal in a 2–0 win after coming off the bench for Lautaro Martínez, which enabled them to advanced to the knock-out stages of the competition.
In the third-place match against Chile on 6 July, Dybala made his first start of the tournament, and scored Argentina's second goal in an eventual 2–1 win, to help his team capture the bronze medal.
Due to his family heritage, Dybala was eligible to play for Poland and Italy, but expressly stated that he feels Argentine and had always dreamed of playing for Argentina. Dybala stated "I feel 100 percent Argentinian, I wouldn't be happy in a national team that didn't feel like mine, to hear an anthem that isn't my own, in colours that don't belong to me".
Dybala was called by the Argentina under-17 team to participate in the XVI Pan American Games, but ultimately did not take part in the competition. On 19 July 2012, he received his first call-up for the under-20 team, but declined the invitation.
On 22 September 2015, Dybala was called for the first time for the Argentina senior team by manager Gerardo Martino, but his first appearance was on 13 October 2015, coming off the bench to replace Carlos Tevez in the 75th minute during a 2018 FIFA World Cup qualifying match against Paraguay. In May 2016, he was omitted from Argentina's 23-man squad for the Copa América Centenario. Although Juventus insisted that they would not release Dybala for the 2016 Summer Olympics in Rio de Janeiro, he was included in Martino's 35-man preliminary under-23 squad for the tournament on 24 May; he was not included in the final squad for the tournament, however.
On 1 September 2016, Dybala was sent off in the first half of a 1–0 home win over Uruguay in a 2018 World Cup qualifier for a second bookable offence. On 13 June 2017, he set up a goal for Joaquín Correa in a 6–0 away friendly win over Singapore.
In May 2018, Dybala was named in Argentina's preliminary 35-man squad for the 2018 FIFA World Cup in Russia; later that month, he was included in Jorge Sampaoli's final 23-man squad for the tournament. He made his World Cup debut in Argentina's second group match on 21 June, coming on as a second-half substitute for Enzo Pérez in the 68th minute of an eventual 3–0 defeat to Croatia. This was his only appearance in the tournament, as Argentina were eliminated in the round of 16 on 30 June, following a 4–3 defeat to France.
Later that year, he scored his first senior international goal on 20 November, in a 2–0 friendly home win over Mexico.
In May 2019, Dybala was included in Argentina manager Lionel Scaloni's preliminary 40-man squad for the 2019 Copa América. Later that month, he was included in the final 23-man squad for the tournament. In Argentina's final group match against Qatar on 23 June, Dybala assisted Agüero's goal in a 2–0 win after coming off the bench for Lautaro Martínez, which enabled them to advanced to the knock-out stages of the competition. In the third-place match against Chile on 6 July, Dybala made his first start of the tournament, and scored Argentina's second goal in an eventual 2–1 win, to help his team capture the bronze medal.
Paulo Dybala