Princess Tsuguko was born on 8 March 1986 at Aiiku Hospital in Minami-Azabu, Tokyo.
She graduated from the Gakushuin Primary School, Gakushuin Girls' Junior and Senior High School.
After that, she entered the Faculty of Intercultural Studies of Gakushuin Women's College, but dropped out in March 2005.
She attended the University of Edinburgh in Scotland from 13 April 2004 to 1 July 2008, where she studied criminal psychology and sociology, but dropped out.

In 2006, Princess Tsuguko represented the Imperial family at the Silver Wedding anniversary celebrations of Grand Duke Henri and Grand Duchess Maria Teresa of Luxembourg.

In 2008, she was included as 15th on the list of "The 20 Hottest Young Royals" as compiled by Forbes magazine, the list ranking young unmarried royals by "international Web and media presence as well as family wealth".

In May 2015, she visited Watari Town, Watari District, Miyagi Prefecture, which had been damaged because of the 2011 Tōhoku earthquake and tsunami, with her mother Hisako.
She visited and inspected the 2nd Regional Coast Guard Headquarters of the Japan Coast Guard.
After that, she also visited the Marine Rescue Miyagi, the regional organization of Marine Rescue Japan (Her mother Hisako officiates as Honorary President), laid flowers to the victims and gave a message of sympathy to the members.
In August 2011, she attended the 28th Tokyo Disabilities Comprehensive Art Exhibition held in the main store of the Seibu Department Stores located in Ikebukuro, Toshima, Tokyo, with her mother Hisako.
She was also taken in the photo with the laureate.

In March 2013, Princess Tsuguko graduated from the School of International Liberal Studies, Waseda University with a bachelor's degree.
She works at the Japan Committee for UNICEF from April 2013.
She attends ceremonies and functions at the Imperial Palace and accompanies her mother to some other official events.
In August 2013, she visited Sri Lanka at the invitation of President Mahinda Rajapaksa.
Japan and Sri Lanka celebrated 60 years of diplomatic relations between those two countries in 2012.
Tsuguko was also welcomed by Shiranthi Rajapaksa.
Princess Tsuguko was born on 8 March 1986 at Aiiku Hospital in Minami-Azabu, Tokyo. She graduated from the Gakushuin Primary School, Gakushuin Girls' Junior and Senior High School. After that, she entered the Faculty of Intercultural Studies of Gakushuin Women's College, but dropped out in March 2005. She attended the University of Edinburgh in Scotland from 13 April 2004 to 1 July 2008, where she studied criminal psychology and sociology, but dropped out.
In 2006, Princess Tsuguko represented the Imperial family at the Silver Wedding anniversary celebrations of Grand Duke Henri and Grand Duchess Maria Teresa of Luxembourg.
In 2008, she was included as 15th on the list of "The 20 Hottest Young Royals" as compiled by Forbes magazine, the list ranking young unmarried royals by "international Web and media presence as well as family wealth".
In May 2015, she visited Watari Town, Watari District, Miyagi Prefecture, which had been damaged because of the 2011 Tōhoku earthquake and tsunami, with her mother Hisako. She visited and inspected the 2nd Regional Coast Guard Headquarters of the Japan Coast Guard. After that, she also visited the Marine Rescue Miyagi, the regional organization of Marine Rescue Japan (Her mother Hisako officiates as Honorary President), laid flowers to the victims and gave a message of sympathy to the members. In August 2011, she attended the 28th Tokyo Disabilities Comprehensive Art Exhibition held in the main store of the Seibu Department Stores located in Ikebukuro, Toshima, Tokyo, with her mother Hisako. She was also taken in the photo with the laureate.
In March 2013, Princess Tsuguko graduated from the School of International Liberal Studies, Waseda University with a bachelor's degree. She works at the Japan Committee for UNICEF from April 2013. She attends ceremonies and functions at the Imperial Palace and accompanies her mother to some other official events. In August 2013, she visited Sri Lanka at the invitation of President Mahinda Rajapaksa. Japan and Sri Lanka celebrated 60 years of diplomatic relations between those two countries in 2012. Tsuguko was also welcomed by Shiranthi Rajapaksa.
Princess Tsuguko of Takamado