Parker starred with Kevin Kline in Grand Canyon (1991); with Kathy Bates, Mary Stuart Masterson, and Jessica Tandy in Fried Green Tomatoes (1991); with Susan Sarandon and Tommy Lee Jones in The Client (1994); with John Cusack in Bullets over Broadway (1994); and with Drew Barrymore and Whoopi Goldberg in Boys on the Side (1995), as a woman with AIDS.
Parker's next role was in a movie adaptation of another Craig Lucas play, Reckless (1995), alongside Mia Farrow, followed by Jane Campion's The Portrait of a Lady 1995 Sugartime(1996), which also starred Nicole Kidman, Viggo Mortensen, Christian Bale, John Malkovich and Barbara Hershey.
In addition, she appeared alongside Matthew Modine in Tim Hunter's The Maker (1997).

Parker's theater career continued when she appeared Off-Broadway in Paula Vogel's 1997 critical smash How I Learned to Drive, with David Morse.
She received the 1997 Lucille Lortel Award, Outstanding Actress, and 1997 Obie Award, Performance for her performance.

In the late 1990s, she appeared in several independent films, including Let the Devil Wear Black and The Five Senses.
She starred alongside Sidney Poitier in the 1999 movie The Simple Life of Noah Dearborn.
Parker starred with Kevin Kline in Grand Canyon (1991); with Kathy Bates, Mary Stuart Masterson, and Jessica Tandy in Fried Green Tomatoes (1991); with Susan Sarandon and Tommy Lee Jones in The Client (1994); with John Cusack in Bullets over Broadway (1994); and with Drew Barrymore and Whoopi Goldberg in Boys on the Side (1995), as a woman with AIDS. Parker's next role was in a movie adaptation of another Craig Lucas play, Reckless (1995), alongside Mia Farrow, followed by Jane Campion's The Portrait of a Lady 1995 Sugartime(1996), which also starred Nicole Kidman, Viggo Mortensen, Christian Bale, John Malkovich and Barbara Hershey. In addition, she appeared alongside Matthew Modine in Tim Hunter's The Maker (1997).
Parker's theater career continued when she appeared Off-Broadway in Paula Vogel's 1997 critical smash How I Learned to Drive, with David Morse. She received the 1997 Lucille Lortel Award, Outstanding Actress, and 1997 Obie Award, Performance for her performance.
In the late 1990s, she appeared in several independent films, including Let the Devil Wear Black and The Five Senses. She starred alongside Sidney Poitier in the 1999 movie The Simple Life of Noah Dearborn.
Mary-Louise Parker