In Michigan, US 127 runs from the Ohio border south of Hudson north to the junction with I-75, four miles (6.4 km) south of Grayling, a distance of 212.12 miles (341.37 km).

The highway is the primary route connecting Lansing and central Michigan to Northern Michigan and the Mackinac Bridge; it serves the cities of Jackson, Lansing, and Clare.
 From the south side of Jackson northerly, it is mostly a four-lane freeway, except for the notable exception of a 16-mile (26 km) stretch from north of St. Johns to just south of Ithaca, where access to the road is not limited.

Prior to 2002, US 127 ran from I-69 north of East Lansing southerly to the Ohio border near Hudson, a total of 83 miles (134 km).
From the Ohio border until Jackson, the highway follows the course (with minor deviations) of the Michigan Meridian used to survey Michigan in the early 19th century.
That stretch is generally named Meridian Road.

In the non-freeway sections of the route, it is known as Bagley Road.

A proposed I-73 would incorporate US 127 between Jackson and Grayling.
In Michigan, US 127 runs from the Ohio border south of Hudson north to the junction with I-75, four miles (6.4 km) south of Grayling, a distance of 212.12 miles (341.37 km).
The highway is the primary route connecting Lansing and central Michigan to Northern Michigan and the Mackinac Bridge; it serves the cities of Jackson, Lansing, and Clare.  From the south side of Jackson northerly, it is mostly a four-lane freeway, except for the notable exception of a 16-mile (26 km) stretch from north of St. Johns to just south of Ithaca, where access to the road is not limited.
Prior to 2002, US 127 ran from I-69 north of East Lansing southerly to the Ohio border near Hudson, a total of 83 miles (134 km). From the Ohio border until Jackson, the highway follows the course (with minor deviations) of the Michigan Meridian used to survey Michigan in the early 19th century. That stretch is generally named Meridian Road.
In the non-freeway sections of the route, it is known as Bagley Road.
A proposed I-73 would incorporate US 127 between Jackson and Grayling.
U.S. Route 127