At LSU, Bregman majored in sports administration.
He also played shortstop for the LSU Tigers baseball team in the Southeastern Conference (SEC).
 He wore number 30 as a freshman, reflecting the 30 teams that had passed on him in the first round of the 2012 draft.

In 2013, he batted .369/.417/.546 with 104 hits (second in the nation), 18 doubles (third in the SEC), seven triples, six homers, 52 RBIs, 59 runs, and 16 steals in 17 attempts, and had a 23-game hitting streak.
Bregman won the 2013 Brooks Wallace Award as the country's best college shortstop.
He was also voted first-team All-American by Baseball America, the American Baseball Coaches Association (ABCA), Perfect Game, and the Jewish Sports Review.
 In addition, he was named the 2013 National Freshman of the Year by Baseball America, Collegiate Baseball, and the National Collegiate Baseball Writers Association (NCBWA), and was voted 2013 SEC Freshman of the Year and first-team all-SEC by the league coaches.
 Moreover, he was named 2013 ABCA First-Team All-South Region, National Collegiate Athletic Association (NCAA) Baton Rouge Regional Most Outstanding Player, Louisiana Freshman of the Year, and SEC Player of the Week (March 25, 2013), and named to the 2013 USA Collegiate National Team (for which he batted .361).

In 2014, he batted .316/.397/.455 with 16 doubles, 6 home runs, 35 runs, and 12 stolen bases.
Bregman was voted 2014 second-team all-SEC, NCAA Regional All-Tournament Team, SEC All-Tournament Team, Second-Team All-Louisiana, and named to the 2014 USA Collegiate National Team.
He shared an apartment that season with teammate and future fellow major league All Star Aaron Nola.

In 2015, Bregman batted .312/.406/.534 with 22 doubles (tops in the SEC), 9 home runs, 49 RBIs, 37 stolen bases (leading the SEC, and the second-most steals in a season in LSU history), and 206 assists (leading the conference), led the nation's No.
1-ranked baseball team to the College World Series, and won LSU's Skip Bertman Award, which goes to the player who best exemplifies the spirit of the LSU Baseball program.
He was also voted the Rawlings Gold Glove winner at shortstop by the ABCA, and voted first-team All-American by both Baseball America and the NCBWA for the second time, First Team D1Baseball, First Team Perfect Game, and Second Team Collegiate Baseball.

He was one of four finalists for the 2015 Golden Spikes Award, presented annually to the nation's top college player and won by outfielder Andrew Benintendi.
Also, he was a candidate once more for the Brooks Wallace Shortstop of the Year Award that he had won in 2013.

In 190 career games at LSU, Bregman batted .338/.412/.520, with 66 strikeouts and 87 walks in 761 at bats.
At LSU, Bregman majored in sports administration. He also played shortstop for the LSU Tigers baseball team in the Southeastern Conference (SEC).  He wore number 30 as a freshman, reflecting the 30 teams that had passed on him in the first round of the 2012 draft.
In 2013, he batted .369/.417/.546 with 104 hits (second in the nation), 18 doubles (third in the SEC), seven triples, six homers, 52 RBIs, 59 runs, and 16 steals in 17 attempts, and had a 23-game hitting streak. Bregman won the 2013 Brooks Wallace Award as the country's best college shortstop. He was also voted first-team All-American by Baseball America, the American Baseball Coaches Association (ABCA), Perfect Game, and the Jewish Sports Review.  In addition, he was named the 2013 National Freshman of the Year by Baseball America, Collegiate Baseball, and the National Collegiate Baseball Writers Association (NCBWA), and was voted 2013 SEC Freshman of the Year and first-team all-SEC by the league coaches.  Moreover, he was named 2013 ABCA First-Team All-South Region, National Collegiate Athletic Association (NCAA) Baton Rouge Regional Most Outstanding Player, Louisiana Freshman of the Year, and SEC Player of the Week (March 25, 2013), and named to the 2013 USA Collegiate National Team (for which he batted .361).
In 2014, he batted .316/.397/.455 with 16 doubles, 6 home runs, 35 runs, and 12 stolen bases. Bregman was voted 2014 second-team all-SEC, NCAA Regional All-Tournament Team, SEC All-Tournament Team, Second-Team All-Louisiana, and named to the 2014 USA Collegiate National Team. He shared an apartment that season with teammate and future fellow major league All Star Aaron Nola.
In 2015, Bregman batted .312/.406/.534 with 22 doubles (tops in the SEC), 9 home runs, 49 RBIs, 37 stolen bases (leading the SEC, and the second-most steals in a season in LSU history), and 206 assists (leading the conference), led the nation's No. 1-ranked baseball team to the College World Series, and won LSU's Skip Bertman Award, which goes to the player who best exemplifies the spirit of the LSU Baseball program. He was also voted the Rawlings Gold Glove winner at shortstop by the ABCA, and voted first-team All-American by both Baseball America and the NCBWA for the second time, First Team D1Baseball, First Team Perfect Game, and Second Team Collegiate Baseball.
He was one of four finalists for the 2015 Golden Spikes Award, presented annually to the nation's top college player and won by outfielder Andrew Benintendi. Also, he was a candidate once more for the Brooks Wallace Shortstop of the Year Award that he had won in 2013.
In 190 career games at LSU, Bregman batted .338/.412/.520, with 66 strikeouts and 87 walks in 761 at bats.
Alex Bregman