With the defeat of the Ionian fleet, the revolt was effectively over.
Miletus was closely invested, the Persians "mining the walls and using every device against it, until they utterly captured it".
According to Herodotus, most of the men were killed, and the women and children were enslaved.
Archaeological evidence partially substantiates this, showing widespread signs of destruction, and abandonment of much of the city in the aftermath of Lade.
However, some Milesians did remain in (or quickly returned to) Miletus, though the city would never recapture its former greatness.
Miletus was thus notionally "left empty of Milesians"; the Persians took the city and coastal land for themselves, and gave the rest of the Milesian territory to Carians from Pedasus.
The captive Milesians were brought before Darius in Susa, who settled them on the coast of the Persian Gulf, near the mouth of the Tigris.

Many Samians were appalled by the actions of their generals at Lade, and resolved to emigrate before their old tyrant, Aeaces, returned to rule them.
They accepted an invitation from the people of Zancle to settle on the coast of Sicily, and took with them such Milesians as had escaped from the Persians.
Samos itself was spared from destruction by the Persians because of the Samian defection at Lade.
Meanwhile, Dionysius of Phocaea went to Sicily, and established himself as a pirate, preying on Carthaginian ships.

Most of Caria surrendered to the Persians in aftermath of Lade, although some strongholds had to be captured through force.
The Persian fleet and army wintered at Miletus, before setting out in 493 BC to finally stamp out the last embers of the revolt.
They attacked and captured the islands of Chios, Lesbos and Tenedos and then moved over to the mainland, and captured each of the remaining cities of Ionia.
Although the cities of Ionia were undoubtedly harrowed in the aftermath, none seems to have suffered quite the fate of Miletus.
The Persian army then re-conquered the settlements on the Asian side of the Propontis, while the fleet sailed up the European coast of the Hellespont, taking each settlement in turn.
With all of Asia Minor now firmly returned to Persian rule, the revolt was finally over.

For the Persians, the only unfinished business that remained by the end of 493 BC was to exact punishment on Athens and Eretria for supporting the revolt.
The Ionian Revolt had severely threatened the stability of Darius's empire, and the states of mainland Greece would continue to threaten that stability unless dealt with.
Darius thus began to contemplate the complete conquest of Greece, beginning with the destruction of Athens and Eretria.
The first Persian invasion of Greece thus began in the following year, 492 BC, when Mardonius was dispatched (via Ionia) to complete the pacification of the land approaches to Greece, and push on to Athens and Eretria if possible.
Thrace was re-subjugated, having broken loose from Persian rule during the revolts, and Macedon compelled to become a vassal of Persia.
However, progress was halted by a naval disaster.
A second expedition was launched in 490 BC under Datis and Artaphernes, son of the satrap Artaphernes.
This amphibious force sailed across the Aegean, subjugating the Cyclades, before arriving off Euboea.
Eretria was besieged, captured and destroyed, and the force then moved onto Attica.
Landing at the Bay of Marathon, they were met by an Athenian army, and defeated in the famous Battle of Marathon, ending the first Persian attempt to subdue Greece.
With the defeat of the Ionian fleet, the revolt was effectively over. Miletus was closely invested, the Persians "mining the walls and using every device against it, until they utterly captured it". According to Herodotus, most of the men were killed, and the women and children were enslaved. Archaeological evidence partially substantiates this, showing widespread signs of destruction, and abandonment of much of the city in the aftermath of Lade. However, some Milesians did remain in (or quickly returned to) Miletus, though the city would never recapture its former greatness. Miletus was thus notionally "left empty of Milesians"; the Persians took the city and coastal land for themselves, and gave the rest of the Milesian territory to Carians from Pedasus. The captive Milesians were brought before Darius in Susa, who settled them on the coast of the Persian Gulf, near the mouth of the Tigris.
Many Samians were appalled by the actions of their generals at Lade, and resolved to emigrate before their old tyrant, Aeaces, returned to rule them. They accepted an invitation from the people of Zancle to settle on the coast of Sicily, and took with them such Milesians as had escaped from the Persians. Samos itself was spared from destruction by the Persians because of the Samian defection at Lade. Meanwhile, Dionysius of Phocaea went to Sicily, and established himself as a pirate, preying on Carthaginian ships.
Most of Caria surrendered to the Persians in aftermath of Lade, although some strongholds had to be captured through force. The Persian fleet and army wintered at Miletus, before setting out in 493 BC to finally stamp out the last embers of the revolt. They attacked and captured the islands of Chios, Lesbos and Tenedos and then moved over to the mainland, and captured each of the remaining cities of Ionia. Although the cities of Ionia were undoubtedly harrowed in the aftermath, none seems to have suffered quite the fate of Miletus. The Persian army then re-conquered the settlements on the Asian side of the Propontis, while the fleet sailed up the European coast of the Hellespont, taking each settlement in turn. With all of Asia Minor now firmly returned to Persian rule, the revolt was finally over.
For the Persians, the only unfinished business that remained by the end of 493 BC was to exact punishment on Athens and Eretria for supporting the revolt. The Ionian Revolt had severely threatened the stability of Darius's empire, and the states of mainland Greece would continue to threaten that stability unless dealt with. Darius thus began to contemplate the complete conquest of Greece, beginning with the destruction of Athens and Eretria. The first Persian invasion of Greece thus began in the following year, 492 BC, when Mardonius was dispatched (via Ionia) to complete the pacification of the land approaches to Greece, and push on to Athens and Eretria if possible. Thrace was re-subjugated, having broken loose from Persian rule during the revolts, and Macedon compelled to become a vassal of Persia. However, progress was halted by a naval disaster. A second expedition was launched in 490 BC under Datis and Artaphernes, son of the satrap Artaphernes. This amphibious force sailed across the Aegean, subjugating the Cyclades, before arriving off Euboea. Eretria was besieged, captured and destroyed, and the force then moved onto Attica. Landing at the Bay of Marathon, they were met by an Athenian army, and defeated in the famous Battle of Marathon, ending the first Persian attempt to subdue Greece.
Battle of Lade