Melrose was settled in the second half of the 19th century at the crossing of the Bellamy Road (now State Road 26) and the Starke-Orange Springs Road (now State Road 21), near the Eliam Church and Shakerag race course, and about one mile from the older settlement of Banana.
The new town was named Melrose after Melrose Abbey in Melrose, Scotland.
It was reported that the ladies of the town did not want it to be known as Shakerag.
The town of Melrose included part of the Shakerag race course, but there was no settlement at the Shakerag race course before Melrose was settled, and Tolles states that "[t]o say Melrose used to be called Shake Rag is poetic license."

In the late 1800s, the citrus industry thrived in the area.
Local growers would bring their yearly harvest to Melrose, where it was loaded onto steam ships in Lake Santa Fe.
The ships would then steam from lake Santa Fe to Lake Alto, and then Lake Alto to the town of Waldo using man made canals.
The citrus was then transported by rail across the United States.
The rail was known as the Lake Santa Fe Route to most people who lived in the area at the time.
During this, families moved into houses around Lake Santa Fe and the citrus groves.
In 1894, however, two devastating freezes hit the Melrose area and destroyed local groves.
Growers then relocated to warmer areas in the central and southern parts of Florida.

For the rest of the 20th century, citrus farming was rebuilt, but not as large and powerful as it was in the 19th century.
Also during this time period, grapevine farms were founded around and outside the community.
On January 12, 1990, the Melrose Historic District was designated a U.S. historic district.
It encompasses 1,250 acres (5.1 km²), and contains dozens of historic buildings, the most well-known being the Trinity Episcopal Church.
During the 20th century, also, was that many small businesses and restaurants were built and thrived, making the city a stopping place for travellers going into other states like Georgia and Alabama.
Fishing in Lake Santa Fe became more popular with locals, as catfish, bass, and other animals could be caught.
Melrose was settled in the second half of the 19th century at the crossing of the Bellamy Road (now State Road 26) and the Starke-Orange Springs Road (now State Road 21), near the Eliam Church and Shakerag race course, and about one mile from the older settlement of Banana. The new town was named Melrose after Melrose Abbey in Melrose, Scotland. It was reported that the ladies of the town did not want it to be known as Shakerag. The town of Melrose included part of the Shakerag race course, but there was no settlement at the Shakerag race course before Melrose was settled, and Tolles states that "[t]o say Melrose used to be called Shake Rag is poetic license."
In the late 1800s, the citrus industry thrived in the area. Local growers would bring their yearly harvest to Melrose, where it was loaded onto steam ships in Lake Santa Fe. The ships would then steam from lake Santa Fe to Lake Alto, and then Lake Alto to the town of Waldo using man made canals. The citrus was then transported by rail across the United States. The rail was known as the Lake Santa Fe Route to most people who lived in the area at the time. During this, families moved into houses around Lake Santa Fe and the citrus groves. In 1894, however, two devastating freezes hit the Melrose area and destroyed local groves. Growers then relocated to warmer areas in the central and southern parts of Florida.
For the rest of the 20th century, citrus farming was rebuilt, but not as large and powerful as it was in the 19th century. Also during this time period, grapevine farms were founded around and outside the community. On January 12, 1990, the Melrose Historic District was designated a U.S. historic district. It encompasses 1,250 acres (5.1 km²), and contains dozens of historic buildings, the most well-known being the Trinity Episcopal Church. During the 20th century, also, was that many small businesses and restaurants were built and thrived, making the city a stopping place for travellers going into other states like Georgia and Alabama. Fishing in Lake Santa Fe became more popular with locals, as catfish, bass, and other animals could be caught.
Melrose, Florida