Lord Lathom married Lady Alice Villiers, daughter of George Villiers, 4th Earl of Clarendon, on 16 August 1860.
They had nine children:
Edward George Bootle-Wilbraham, 2nd Earl of Lathom (1864–1910), married 1889 Lady Wilma Pleydell-Bouverie, daughter of William Pleydell-Bouverie, 5th Earl of Radnor.

Hon.
Villiers Richard Bootle-Wilbraham, born abt.
1867, married 1900 to Violet Inez de Romero.

Hon.
Reginald Francis Bootle-Wilbraham, born abt.
1875, married 1903 to Lilian Mary Holt, daughter of Major William Lyster Holt
Lady Alice Maud Bootle-Wilbraham, O.B.E.
Lady Constance Adela Bootle-Wilbraham, married Onorato Caetani, 14th Duke of Sermoneta and 4th Prince of Teano
Lady Bertha Mabel Bootle-Wilbraham, married 1903 to Maj.
Arthur Frederick Dawkins
Lady Edith Cecil.
Bootle-Wilbraham.bap Jan 1870.
Died 1899.

Lady Florence Mary Bootle-Wilbraham (d. 1944), married the Right Reverend Lord William Cecil, Bishop of Exeter, son of Robert Gascoyne-Cecil, 3rd Marquess of Salisbury, and had issue.

The Countess of Lathom died in a carriage accident in November 1897, aged 56.
Lady Alice's Drive, opposite Blythe Hall, is named after her.
Lord Lathom survived her by a year and died in November 1898, aged 60.
He was succeeded in his titles by his eldest son, Edward, Lord Skelmersdale.
Lord Lathom married Lady Alice Villiers, daughter of George Villiers, 4th Earl of Clarendon, on 16 August 1860. They had nine children:
Edward George Bootle-Wilbraham, 2nd Earl of Lathom (1864–1910), married 1889 Lady Wilma Pleydell-Bouverie, daughter of William Pleydell-Bouverie, 5th Earl of Radnor.
Hon. Villiers Richard Bootle-Wilbraham, born abt. 1867, married 1900 to Violet Inez de Romero.
Hon. Reginald Francis Bootle-Wilbraham, born abt. 1875, married 1903 to Lilian Mary Holt, daughter of Major William Lyster Holt
Lady Alice Maud Bootle-Wilbraham, O.B.E.
Lady Constance Adela Bootle-Wilbraham, married Onorato Caetani, 14th Duke of Sermoneta and 4th Prince of Teano
Lady Bertha Mabel Bootle-Wilbraham, married 1903 to Maj. Arthur Frederick Dawkins
Lady Edith Cecil. Bootle-Wilbraham.bap Jan 1870. Died 1899.
Lady Florence Mary Bootle-Wilbraham (d. 1944), married the Right Reverend Lord William Cecil, Bishop of Exeter, son of Robert Gascoyne-Cecil, 3rd Marquess of Salisbury, and had issue.
The Countess of Lathom died in a carriage accident in November 1897, aged 56. Lady Alice's Drive, opposite Blythe Hall, is named after her. Lord Lathom survived her by a year and died in November 1898, aged 60. He was succeeded in his titles by his eldest son, Edward, Lord Skelmersdale.
Edward Bootle-Wilbraham, 1st Earl of Lathom