On 31 March 1425 at Settimo Pavese, Agnese gave birth to Filippo's daughter, whom they named Bianca Maria.
When the baby was six months old, Agnese and Bianca Maria were sent to the castle of Abbiategrasso, where lavish apartments were provided for mother and child.
In 1426, Agnese bore the Duke a second daughter, Caterina Maria, but the child died shortly after her birth.
Filippo, for reasons of state, married secondly, by proxy on 2 December 1427, and in person on 24 September 1428, Marie of Savoy (January 1411 – 22 February 1479), the daughter of Amadeus VIII of Savoy and Marie of Burgundy.
The duke's second marriage was also childless, making Bianca Maria his sole heir to the duchy of Milan.

On 25 October 1441, Bianca Maria was married, in a magnificent ceremony at the Abbey of San Sigismondo in Cremona, to Francesco Sforza, a renowned Condottiero and member of the Condottieri Sforza family.
Agnese was present at her daughter's wedding.
The extravagant festivities, which lasted for days, offered a sumptuous banquet, a series of tournaments, a palio, painted carts featuring allegorical scenes, and an oversized cake that reproduced  the Torrazzo, Cremona's most prominent tower.
Bianca Maria's considerable dowry included the towns of Cremona and Pontremoli.
The marriage produced eight children, among these were, Galeazzo Maria Sforza, Duke of Milan, Ludovico Sforza, Duke of Milan, Cardinal Ascanio Sforza, and Ippolita Maria Sforza, Duchess of Calabria.
On 31 March 1425 at Settimo Pavese, Agnese gave birth to Filippo's daughter, whom they named Bianca Maria. When the baby was six months old, Agnese and Bianca Maria were sent to the castle of Abbiategrasso, where lavish apartments were provided for mother and child. In 1426, Agnese bore the Duke a second daughter, Caterina Maria, but the child died shortly after her birth. Filippo, for reasons of state, married secondly, by proxy on 2 December 1427, and in person on 24 September 1428, Marie of Savoy (January 1411 – 22 February 1479), the daughter of Amadeus VIII of Savoy and Marie of Burgundy. The duke's second marriage was also childless, making Bianca Maria his sole heir to the duchy of Milan.
On 25 October 1441, Bianca Maria was married, in a magnificent ceremony at the Abbey of San Sigismondo in Cremona, to Francesco Sforza, a renowned Condottiero and member of the Condottieri Sforza family. Agnese was present at her daughter's wedding. The extravagant festivities, which lasted for days, offered a sumptuous banquet, a series of tournaments, a palio, painted carts featuring allegorical scenes, and an oversized cake that reproduced  the Torrazzo, Cremona's most prominent tower. Bianca Maria's considerable dowry included the towns of Cremona and Pontremoli. The marriage produced eight children, among these were, Galeazzo Maria Sforza, Duke of Milan, Ludovico Sforza, Duke of Milan, Cardinal Ascanio Sforza, and Ippolita Maria Sforza, Duchess of Calabria.
Agnese del Maino