Wilsonville has often had more jobs in the city than residents due to its location along Interstate 5.
This location has led to the city becoming headquarters for several major local and national companies, as well as home to facilities of several national companies.
Companies with their headquarters in the city include design software maker Mentor Graphics; imaging systems manufacturer FLIR Systems; and shoe retailer Solestruck.
G.I. Joe's, a sporting goods and automotive parts retailer was based in Wilsonville until bankruptcy in 2009, as was drugstore chain Thrifty PayLess until it was bought by Rite Aid in 1996, and video rental retailer Movie Gallery and its subsidiary Hollywood Video were as well until bankruptcy in 2010.

Copier and printer manufacturer Xerox operates a large facility in Wilsonville, and is the city's largest employer.
 The company acquired the color printing and imaging division of Tektronix corporation in 2000.
Xerox, Mentor Graphics, and FLIR are all adjacent to each other north of Boeckman Road along Parkway Avenue.
Projector maker InFocus was headquartered in the city until December 2009 and was located next to FLIR.
InFocus and Mentor were both founded by former employees of Tektronix.

Wilsonville is home to many other business located in industrial parks straddling Interstate 5 that are filled with manufacturing and distribution facilities.
Xerox and Mentor Graphics are the city's two largest employers as of 2006, the only two to employ more than 1000 people.
Other large employers in the city are Tyco Electronics (Precision Interconnect), Sysco, Rockwell Collins, and Rite Aid.
Additionally, Coca-Cola operates a bottling plant in the city.
Nike had one of its U.S. distribution centers for footwear in Wilsonville until closing it in 2009.

Retail in Wilsonville is concentrated mainly along Wilsonville Road near the Interstate 5 interchange.
This includes the Town Center Shopping Center and related developments along Town Center Loop, which includes Fry's Electronics, one of the largest employers in the city.
Fred Meyer opened a 145,000-square-foot (13,500 m²) store along with space for 20 other businesses at their Old Town Square where Boones Ferry and Wilsonville roads meet.
At the north end of town is the 42-acre (17 ha) Argyle Square shopping center that opened in 2003, which includes a Target store, Office Depot, and Costco as anchor tenants.
South of the Willamette River, Charbonneau has a small commercial center with about 10 shops.

Microsoft had a plant, producing the Surface Hub, from 2015 to mid-2017, with the loss of 124 jobs.
Wilsonville has often had more jobs in the city than residents due to its location along Interstate 5. This location has led to the city becoming headquarters for several major local and national companies, as well as home to facilities of several national companies. Companies with their headquarters in the city include design software maker Mentor Graphics; imaging systems manufacturer FLIR Systems; and shoe retailer Solestruck. G.I. Joe's, a sporting goods and automotive parts retailer was based in Wilsonville until bankruptcy in 2009, as was drugstore chain Thrifty PayLess until it was bought by Rite Aid in 1996, and video rental retailer Movie Gallery and its subsidiary Hollywood Video were as well until bankruptcy in 2010.
Copier and printer manufacturer Xerox operates a large facility in Wilsonville, and is the city's largest employer.  The company acquired the color printing and imaging division of Tektronix corporation in 2000. Xerox, Mentor Graphics, and FLIR are all adjacent to each other north of Boeckman Road along Parkway Avenue. Projector maker InFocus was headquartered in the city until December 2009 and was located next to FLIR. InFocus and Mentor were both founded by former employees of Tektronix.
Wilsonville is home to many other business located in industrial parks straddling Interstate 5 that are filled with manufacturing and distribution facilities. Xerox and Mentor Graphics are the city's two largest employers as of 2006, the only two to employ more than 1000 people. Other large employers in the city are Tyco Electronics (Precision Interconnect), Sysco, Rockwell Collins, and Rite Aid. Additionally, Coca-Cola operates a bottling plant in the city. Nike had one of its U.S. distribution centers for footwear in Wilsonville until closing it in 2009.
Retail in Wilsonville is concentrated mainly along Wilsonville Road near the Interstate 5 interchange. This includes the Town Center Shopping Center and related developments along Town Center Loop, which includes Fry's Electronics, one of the largest employers in the city. Fred Meyer opened a 145,000-square-foot (13,500 m²) store along with space for 20 other businesses at their Old Town Square where Boones Ferry and Wilsonville roads meet. At the north end of town is the 42-acre (17 ha) Argyle Square shopping center that opened in 2003, which includes a Target store, Office Depot, and Costco as anchor tenants. South of the Willamette River, Charbonneau has a small commercial center with about 10 shops.
Microsoft had a plant, producing the Surface Hub, from 2015 to mid-2017, with the loss of 124 jobs.
Wilsonville, Oregon