The connection with silk production ended in about 1908 when F.W. Hampshire and Company, the chemists, moved into the premises to make fly papers and cough medicines.
On 5 December 1910 at 5.00 am, fire broke out in the adjacent Sowter Brothers flour mill and engulfed the Silk Mill.
The mill's east wall fell into the river and the building was gutted.
Great efforts were made by the borough fire brigade and the Midland Railway Company who saved the shell of the tower and the outline of the doorways leading into the original five floors.
These can be seen today on the tower staircase.
The building was rebuilt to the same height but with three storeys instead of five and remains that way today.

During the 1920s, ownership passed to the Electricity Authority.
It was used as stores, workshops and a canteen.
Hidden from the road by the power station, its existence was forgotten by the public until the power station was demolished in 1970.
It was then adapted for use as Derby’s Industrial Museum, which opened on 29 November 1974.
The connection with silk production ended in about 1908 when F.W. Hampshire and Company, the chemists, moved into the premises to make fly papers and cough medicines. On 5 December 1910 at 5.00 am, fire broke out in the adjacent Sowter Brothers flour mill and engulfed the Silk Mill. The mill's east wall fell into the river and the building was gutted. Great efforts were made by the borough fire brigade and the Midland Railway Company who saved the shell of the tower and the outline of the doorways leading into the original five floors. These can be seen today on the tower staircase. The building was rebuilt to the same height but with three storeys instead of five and remains that way today.
During the 1920s, ownership passed to the Electricity Authority. It was used as stores, workshops and a canteen. Hidden from the road by the power station, its existence was forgotten by the public until the power station was demolished in 1970. It was then adapted for use as Derby’s Industrial Museum, which opened on 29 November 1974.
Lombe's Mill