As a junior, Van Meirhaeghe won the 2010 Junior Tour of Flanders.
After a year riding for the Soenens–Construkt Glas team, he rode for the Lotto-Belisol Under-23 team from 2012 to 2014.
In February 2014, he finished on the podium of the under-23 edition of Omloop Het Nieuwsblad, having been in a breakaway with the eventual race winner, Dimitri Claeys.
In May 2014, he finished in the top ten of the Paris–Arras Tour, his best stage-race result to that point.
During this time he rode principally as a domestique for other riders, rarely having a chance to race for himself.

In August 2014, Van Meirhaeghe became the under-23 Belgian national road race champion, winning the race in a solo breakaway despite a gear-shift problem.
Shortly after this victory, it was announced that Van Meirhaeghe was among six neo-professionals to sign for the Topsport Vlaanderen–Baloise Professional Continental cycling team for the 2015 season.
As a junior, Van Meirhaeghe won the 2010 Junior Tour of Flanders. After a year riding for the Soenens–Construkt Glas team, he rode for the Lotto-Belisol Under-23 team from 2012 to 2014. In February 2014, he finished on the podium of the under-23 edition of Omloop Het Nieuwsblad, having been in a breakaway with the eventual race winner, Dimitri Claeys. In May 2014, he finished in the top ten of the Paris–Arras Tour, his best stage-race result to that point. During this time he rode principally as a domestique for other riders, rarely having a chance to race for himself.
In August 2014, Van Meirhaeghe became the under-23 Belgian national road race champion, winning the race in a solo breakaway despite a gear-shift problem. Shortly after this victory, it was announced that Van Meirhaeghe was among six neo-professionals to sign for the Topsport Vlaanderen–Baloise Professional Continental cycling team for the 2015 season.
Jef Van Meirhaeghe