From 1998–2002, Towle served as the editor in chief of Genre magazine, a North American gay men's lifestyle publication, and editor at large for The Out Traveler, an American gay travel quarterly.

Towle's poetry appeared in The Yale Review (May 1991), Ploughshares (Winter 1992-93), The Paris Review in 2000, and in Poetry Magazine (July 1988, November 1988, February 1991, May 1997, and July 1999).

Towle founded the website Towleroad in 2003.
The site focuses on LGBTQ news and entertainment.
In 2005, OUT magazine co-founder Michael Goff became his business partner.
Since 2014, Towle and Goff have also published Ptown Hacks, a travel guide to Provincetown.
From 1998–2002, Towle served as the editor in chief of Genre magazine, a North American gay men's lifestyle publication, and editor at large for The Out Traveler, an American gay travel quarterly.
Towle's poetry appeared in The Yale Review (May 1991), Ploughshares (Winter 1992-93), The Paris Review in 2000, and in Poetry Magazine (July 1988, November 1988, February 1991, May 1997, and July 1999).
Towle founded the website Towleroad in 2003. The site focuses on LGBTQ news and entertainment. In 2005, OUT magazine co-founder Michael Goff became his business partner. Since 2014, Towle and Goff have also published Ptown Hacks, a travel guide to Provincetown.
Andy Towle