In 2001, he played the lead role of Gallic chieftain Vercingetorix in the France-Canada production Druids.
He also starred in John Glen's The Point Men, about a team of Israeli agents being killed off one-by-one after a botched anti-terrorist operation.
He also provided his voice for the English dub of the animated series Mazinkaiser.

In 2002, he was an executive producer and a co-lead in the thriller The Piano Player, with Dennis Hopper.
He also provided his voice for the English dub of the animated series Jing: King of Bandits.

In 2003, he played in Absolon, a post-apocalyptic science fiction thriller film.
He also played a supporting role in the French film Janis and John.
He also acted in the short film Qui veut la peau de Roberto Santini?.

In 2004, he acted opposite Nastassja Kinski in the French film À ton image.
He also played in one episode of Cirque du Soleil: Solstrom.
He was an executive producer on the film The Confessor starring Christian Slater, Molly Parker, and Stephen Rea.
The film follows a straying Catholic priest's, played by Slater, investigation of a troubled teen's mysterious death.
It was nominated for two awards at the Directors Guild of Canada.

In 2005, he acted in the television film biopic Dalida.

In 2006, he was an executive producer and star on the film Day of Wrath.
He starred in the French film Le Lièvre de Vatanen.
He also played a supporting role in Richard Kelly's Southland Tales.

In 2007, he starred in the vampire film Metamorphosis.
He starred in the French film Trivial, directed by Sophie Marceau.
It's about a police inspector, struggling with depression following his wife's death, who investigates a suspicious missing person's case at the request of a mysterious woman.
During that time, he started a relationship with Marceau.

In 2008, he played in the French crime thriller Limousine.
In 2009, Lambert was a lead in Claire Denis' White Material; both the film and Lambert's performance received critical acclaim.
The film stars Isabelle Huppert as a struggling French coffee producer in an unnamed French speaking African country, who decides to stay at her coffee plantation in spite of an erupting civil war.
The film has appeared on a number of critics' top ten lists of the best films of 2010.
It was nominated at the Denver Film Critics Society Award for Best Foreign Language Film, for a Golden Lion, a Satellite Award for Best Foreign Language Film, at the Washington DC Area Film Critics Association, etc.

That year he also acted in Cartagena with Sophie Marceau.
The film is about a beautiful, free-spirited woman who becomes bedridden following a terrible accident.
Against her better judgement, she hires a drunk middle-aged former boxer to cook and care for her.
Although unqualified for the position, he is desperate to work, and slowly he wins the trust of the woman, who teaches him how to read.
The film also won several awards in France.

Finally he acted in the French television film Les Associés.

In 2010, he played in Philipp Kadelbach's Das Geheimnis der Wale.
The film is about the widow of a whale researcher who joins force with an environmentalist played by Lambert to fight an oil company.
That year he also played the lead in The Gardener of God, a biopic about Gregor Mendel.
In 2001, he played the lead role of Gallic chieftain Vercingetorix in the France-Canada production Druids. He also starred in John Glen's The Point Men, about a team of Israeli agents being killed off one-by-one after a botched anti-terrorist operation. He also provided his voice for the English dub of the animated series Mazinkaiser.
In 2002, he was an executive producer and a co-lead in the thriller The Piano Player, with Dennis Hopper. He also provided his voice for the English dub of the animated series Jing: King of Bandits.
In 2003, he played in Absolon, a post-apocalyptic science fiction thriller film. He also played a supporting role in the French film Janis and John. He also acted in the short film Qui veut la peau de Roberto Santini?.
In 2004, he acted opposite Nastassja Kinski in the French film À ton image. He also played in one episode of Cirque du Soleil: Solstrom. He was an executive producer on the film The Confessor starring Christian Slater, Molly Parker, and Stephen Rea. The film follows a straying Catholic priest's, played by Slater, investigation of a troubled teen's mysterious death. It was nominated for two awards at the Directors Guild of Canada.
In 2005, he acted in the television film biopic Dalida.
In 2006, he was an executive producer and star on the film Day of Wrath. He starred in the French film Le Lièvre de Vatanen. He also played a supporting role in Richard Kelly's Southland Tales.
In 2007, he starred in the vampire film Metamorphosis. He starred in the French film Trivial, directed by Sophie Marceau. It's about a police inspector, struggling with depression following his wife's death, who investigates a suspicious missing person's case at the request of a mysterious woman. During that time, he started a relationship with Marceau.
In 2008, he played in the French crime thriller Limousine. In 2009, Lambert was a lead in Claire Denis' White Material; both the film and Lambert's performance received critical acclaim. The film stars Isabelle Huppert as a struggling French coffee producer in an unnamed French speaking African country, who decides to stay at her coffee plantation in spite of an erupting civil war. The film has appeared on a number of critics' top ten lists of the best films of 2010. It was nominated at the Denver Film Critics Society Award for Best Foreign Language Film, for a Golden Lion, a Satellite Award for Best Foreign Language Film, at the Washington DC Area Film Critics Association, etc.
That year he also acted in Cartagena with Sophie Marceau. The film is about a beautiful, free-spirited woman who becomes bedridden following a terrible accident. Against her better judgement, she hires a drunk middle-aged former boxer to cook and care for her. Although unqualified for the position, he is desperate to work, and slowly he wins the trust of the woman, who teaches him how to read. The film also won several awards in France.
Finally he acted in the French television film Les Associés.
In 2010, he played in Philipp Kadelbach's Das Geheimnis der Wale. The film is about the widow of a whale researcher who joins force with an environmentalist played by Lambert to fight an oil company. That year he also played the lead in The Gardener of God, a biopic about Gregor Mendel.
Christopher Lambert