Ledesma signed with United Soccer League side FC Cincinnati on January 4, 2018.
He was a key player for Cincinnati in the 2018 season, earning 16 goals and a new league record of 16 assists.
He was named USL Player of the Month twice (June and September) and appeared on the USL Team of the Week ten times.
Following the end of the season, he was named the USL Most Valuable Player of 2018, chosen by a vote of media members and team management.

In May 2018, Major League Soccer announced that FC Cincinnati would be joining the league in 2019, meaning a new roster would be formed.
A journalist for ESPN first reported that Ledesma had signed to the new MLS roster in October 2018, but this was not confirmed until the league officially announced his signing on November 26, 2018.
Ledesma was the fourth of ten players from the 2018 roster to be named to the MLS roster.
Ledesma signed with United Soccer League side FC Cincinnati on January 4, 2018. He was a key player for Cincinnati in the 2018 season, earning 16 goals and a new league record of 16 assists. He was named USL Player of the Month twice (June and September) and appeared on the USL Team of the Week ten times. Following the end of the season, he was named the USL Most Valuable Player of 2018, chosen by a vote of media members and team management.
In May 2018, Major League Soccer announced that FC Cincinnati would be joining the league in 2019, meaning a new roster would be formed. A journalist for ESPN first reported that Ledesma had signed to the new MLS roster in October 2018, but this was not confirmed until the league officially announced his signing on November 26, 2018. Ledesma was the fourth of ten players from the 2018 roster to be named to the MLS roster.
Emmanuel Ledesma