The 5.6-acre (2.3 ha) site stretches along the north end of Water Street on Ossining's waterfront, close to the Hudson River and the railroad tracks of Metro-North's Hudson Line and Amtrak's Empire Service.
With the exception of a modern warehouse facility at the end of the street, north of the old main building, they are the only buildings in the area, some still used for industrial or commercial purposes.
The land is level due to the proximity of the river; Water Street generally follows the lower edge of a steep wooded bluff to the north end of the site, where a stream flows into the Hudson and opens a wide gorge.

Just past the fork to Solitude Lane, about 400 feet (120 m) north of the intersection with Snowden Avenue and Westerly Road, are the first set of buildings.
Between the street and the tracks is a gable-roofed one-story brick storage building with segmental-arched windows.
East of the street is a group of small buildings that constituted the factory in its earliest days—Brandreth's office (now demolished), a mixing and packing building, a box-making building and the storage facility that is the oldest building of the group.

Set back a short distance are two single-story buildings.
The northerly of the pair is a Carpenter Gothic-styled one-story structure with a gabled roof, board-and-batten siding and lancet arched windows in the gables.
It was used to dry pills and make boxes, and as office space.
It has been modified greatly since its construction.
The southerly is a flat-roofed brick building used for pill manufacture.

 
To their east, at the edge of the woods, is the oldest building in the factory complex.
It is a two-story three-by-three-bay flat-roofed structure.
Doric pilasters at each corner, along with three at evenly spaced intervals along between windows along the north and south facades, support a blank entablature below the roof.
Their granite bases and capitals complement the granite sills and lintels on the windows.
A modern concrete block addition is attached to the south.
Inside, it retains much of its original furnishing.

Another 150 feet (46 m) to the north, also between the road and the tracks, is a corrugated iron storage facility built on the original factory site.
Its framing, visible on the exterior, consists of timber wrapped in iron.
In both roof gables are simple classically inspired designs, also of iron-wrapped wood.

Further along Water, another 300 feet (91 m), on the east, is the joined complex of three buildings that included the three-story main building.
It was an L-shaped three-story brick structure with a slate-covered mansard roof pierced by four brick chimneys.
The tallest, near the south end of the L, rises two additional stories above the roof.
Windows and doors had brick hood lintels; above the cast iron cornice supported by pendanted brackets were hooded dormer windows in the roof.
Inside there was exposed original brick, segmental-arched entryways, walnut and cast iron roof columns and exposed roof framing.

The main building had two additions: a one-story machine shop on the north side of the western corner, and a large two-story section with a corrugated iron gabled roof and segmental-arched windows without lintels extending east from the north end.
The cleared sites of other additions, as well as several buildings in the bend of the L to the east, are still extant.

To the west of the building, at the street, is a small brick office building with a granite water table.
It is one and a half stories high, three bays by four, with a gabled roof supported by large wooden pendanted brackets.
Its decoration also includes a course of painted brickwork crosses setting off an entablature above in the gable fields with some other isolated brickwork crosses.
Fenestration consists of rectangular windows with granite sills and lintels along the north and south profiles, with an oculus in the gable apex.
Stone steps lead to the paneled wooden and glass doors, sheltered by a curved canopy supported by large brackets at the sides.
Inside the remaining original features include intr
The 5.6-acre (2.3 ha) site stretches along the north end of Water Street on Ossining's waterfront, close to the Hudson River and the railroad tracks of Metro-North's Hudson Line and Amtrak's Empire Service. With the exception of a modern warehouse facility at the end of the street, north of the old main building, they are the only buildings in the area, some still used for industrial or commercial purposes. The land is level due to the proximity of the river; Water Street generally follows the lower edge of a steep wooded bluff to the north end of the site, where a stream flows into the Hudson and opens a wide gorge.
Just past the fork to Solitude Lane, about 400 feet (120 m) north of the intersection with Snowden Avenue and Westerly Road, are the first set of buildings. Between the street and the tracks is a gable-roofed one-story brick storage building with segmental-arched windows. East of the street is a group of small buildings that constituted the factory in its earliest days—Brandreth's office (now demolished), a mixing and packing building, a box-making building and the storage facility that is the oldest building of the group.
Set back a short distance are two single-story buildings. The northerly of the pair is a Carpenter Gothic-styled one-story structure with a gabled roof, board-and-batten siding and lancet arched windows in the gables. It was used to dry pills and make boxes, and as office space. It has been modified greatly since its construction. The southerly is a flat-roofed brick building used for pill manufacture.
 
To their east, at the edge of the woods, is the oldest building in the factory complex. It is a two-story three-by-three-bay flat-roofed structure. Doric pilasters at each corner, along with three at evenly spaced intervals along between windows along the north and south facades, support a blank entablature below the roof. Their granite bases and capitals complement the granite sills and lintels on the windows. A modern concrete block addition is attached to the south. Inside, it retains much of its original furnishing.
Another 150 feet (46 m) to the north, also between the road and the tracks, is a corrugated iron storage facility built on the original factory site. Its framing, visible on the exterior, consists of timber wrapped in iron. In both roof gables are simple classically inspired designs, also of iron-wrapped wood.
Further along Water, another 300 feet (91 m), on the east, is the joined complex of three buildings that included the three-story main building. It was an L-shaped three-story brick structure with a slate-covered mansard roof pierced by four brick chimneys. The tallest, near the south end of the L, rises two additional stories above the roof. Windows and doors had brick hood lintels; above the cast iron cornice supported by pendanted brackets were hooded dormer windows in the roof. Inside there was exposed original brick, segmental-arched entryways, walnut and cast iron roof columns and exposed roof framing.
The main building had two additions: a one-story machine shop on the north side of the western corner, and a large two-story section with a corrugated iron gabled roof and segmental-arched windows without lintels extending east from the north end. The cleared sites of other additions, as well as several buildings in the bend of the L to the east, are still extant.
To the west of the building, at the street, is a small brick office building with a granite water table. It is one and a half stories high, three bays by four, with a gabled roof supported by large wooden pendanted brackets. Its decoration also includes a course of painted brickwork crosses setting off an entablature above in the gable fields with some other isolated brickwork crosses. Fenestration consists of rectangular windows with granite sills and lintels along the north and south profiles, with an oculus in the gable apex. Stone steps lead to the paneled wooden and glass doors, sheltered by a curved canopy supported by large brackets at the sides. Inside the remaining original features include intr
Brandreth Pill Factory