By his wife Helena Dragas, the daughter of the Serbian prince Constantine Dragas, Manuel II Palaiologos had several children, including:
A daughter.
Mentioned as the eldest daughter but not named.
Possibly confused with Isabella Palaiologina, an illegitimate daughter of Manuel II known to have married Ilario Doria.

Constantine Palaiologos.
Born ca.
1393/8, died before 1405 in Monemvasia.

John VIII Palaiologos (18 December 1392 – 31 October 1448).
Byzantine emperor, 1425–1448.

Andronikos Palaiologos, Lord of Thessalonica (d. 1429).

A second daughter.
Also not named in the text.

Theodore II Palaiologos, Lord of Morea (d. 1448).

Michael Palaiologos.
Born 1406/7, died 1409/10 of the plague.

Constantine XI Dragases Palaiologos (8 February 1405 – 29 May 1453).
Despotēs in the Morea and subsequently the last Byzantine emperor, 1448–1453.

Demetrios Palaiologos (c. 1407–1470).
Despotēs in the Morea.

Thomas Palaiologos (c. 1409 – 12 May 1465).
Despotēs in the Morea.
By his wife Helena Dragas, the daughter of the Serbian prince Constantine Dragas, Manuel II Palaiologos had several children, including:
A daughter. Mentioned as the eldest daughter but not named. Possibly confused with Isabella Palaiologina, an illegitimate daughter of Manuel II known to have married Ilario Doria.
Constantine Palaiologos. Born ca. 1393/8, died before 1405 in Monemvasia.
John VIII Palaiologos (18 December 1392 – 31 October 1448). Byzantine emperor, 1425–1448.
Andronikos Palaiologos, Lord of Thessalonica (d. 1429).
A second daughter. Also not named in the text.
Theodore II Palaiologos, Lord of Morea (d. 1448).
Michael Palaiologos. Born 1406/7, died 1409/10 of the plague.
Constantine XI Dragases Palaiologos (8 February 1405 – 29 May 1453). Despotēs in the Morea and subsequently the last Byzantine emperor, 1448–1453.
Demetrios Palaiologos (c. 1407–1470). Despotēs in the Morea.
Thomas Palaiologos (c. 1409 – 12 May 1465). Despotēs in the Morea.
Manuel II Palaiologos