Between 1958 and 1966, London Road was rebuilt in the West Coast Main Line modernisation programme undertaken by British Railways.
It was renamed "Manchester Piccadilly" on 12 September 1960.

The London Midland Region rebuilt the station at a cost of £1.75 million (equivalent to £41,200,000 at 2020 prices) in preparation for electric train services to London.
Most of the station was rebuilt, except for the Victorian trainsheds which remained mostly unaltered, although the two 1880s spans were shortened towards the concourse end.
The station was reconstructed in two phases, 1958–60 and 1963–66; the break was the result of a national credit squeeze restricting funding for railway modernisation.

The former MSJA&R through platforms and bridges over Fairfield Street were rebuilt on a prestressed concrete slab bridge with cantilevered sides for the tracks.
The layout in the trainshed was reconfigured to add several platforms.
A new concourse and entrance were built, alongside which was a ten-storey office block which housed British Rail staff.
On 11 May 1966, work was completed for the introduction of electric expresses to London.

The approach to the station was also redeveloped.
The LNWR goods warehouse alongside the station approach closed in 1965 and a curved office block, Gateway House, was opened in its place in 1969.

Piccadilly remained open throughout the reconstruction, but there was disruption, and many trains were diverted to Manchester Mayfield or Manchester Central stations.
When the work was completed, those stations were no longer required; they were closed and their services were diverted into Piccadilly.
Between 1958 and 1966, London Road was rebuilt in the West Coast Main Line modernisation programme undertaken by British Railways. It was renamed "Manchester Piccadilly" on 12 September 1960.
The London Midland Region rebuilt the station at a cost of £1.75 million (equivalent to £41,200,000 at 2020 prices) in preparation for electric train services to London. Most of the station was rebuilt, except for the Victorian trainsheds which remained mostly unaltered, although the two 1880s spans were shortened towards the concourse end. The station was reconstructed in two phases, 1958–60 and 1963–66; the break was the result of a national credit squeeze restricting funding for railway modernisation.
The former MSJA&R through platforms and bridges over Fairfield Street were rebuilt on a prestressed concrete slab bridge with cantilevered sides for the tracks. The layout in the trainshed was reconfigured to add several platforms. A new concourse and entrance were built, alongside which was a ten-storey office block which housed British Rail staff. On 11 May 1966, work was completed for the introduction of electric expresses to London.
The approach to the station was also redeveloped. The LNWR goods warehouse alongside the station approach closed in 1965 and a curved office block, Gateway House, was opened in its place in 1969.
Piccadilly remained open throughout the reconstruction, but there was disruption, and many trains were diverted to Manchester Mayfield or Manchester Central stations. When the work was completed, those stations were no longer required; they were closed and their services were diverted into Piccadilly.
Manchester Piccadilly station