On 30 January 2016, Khazri joined Sunderland on a four and a half-year contract for an undisclosed fee.
Khazri scored his first goal for Sunderland against Manchester United on 13 February 2016, opening the scoring with a direct free kick that beat David de Gea at his far post.
Khazri later set up Lamine Koné's 82nd-minute goal from a corner, as Sunderland won 2–1.

On 7 May 2016, Khazri scored a volley in a 3–2 win over Chelsea as manager Sam Allardyce's team neared survival in the Premier League.
Richard Mennear of the Sunderland Echo wrote that "His work rate was immense, pressing and probing the Chelsea defence and causing problems from set pieces.
He has regained his form just at the right time".

On 31 August 2017, Khazri returned to Ligue 1, signing a season-long loan at Rennes.
He was sent off on 14 October in a 2–0 Derby Breton loss at Guingamp, earning two yellow cards for dissent within ten seconds.
His nine goals helped the club to 5th place and qualification to the Europa League.
On 30 January 2016, Khazri joined Sunderland on a four and a half-year contract for an undisclosed fee. Khazri scored his first goal for Sunderland against Manchester United on 13 February 2016, opening the scoring with a direct free kick that beat David de Gea at his far post. Khazri later set up Lamine Koné's 82nd-minute goal from a corner, as Sunderland won 2–1.
On 7 May 2016, Khazri scored a volley in a 3–2 win over Chelsea as manager Sam Allardyce's team neared survival in the Premier League. Richard Mennear of the Sunderland Echo wrote that "His work rate was immense, pressing and probing the Chelsea defence and causing problems from set pieces. He has regained his form just at the right time".
On 31 August 2017, Khazri returned to Ligue 1, signing a season-long loan at Rennes. He was sent off on 14 October in a 2–0 Derby Breton loss at Guingamp, earning two yellow cards for dissent within ten seconds. His nine goals helped the club to 5th place and qualification to the Europa League.
Wahbi Khazri