On 11 May 1559, the Charterhouse and the other religious houses of Perth were attacked and destroyed by Protestant "reformers"; one of the brothers was killed, four others fled abroad, while six monks chose to remain; two of those, the prior Adam Forman and a brother, fled in to foreign Carthusian houses in 1567.
Of the four who remained in 1567, one was Adam Stewart, illegitimate son of King James V of Scotland, who for some time styled himself "Prior".
King James VI of Scotland granted the buildings and the gardens of the house to the burgh of Perth on 9 August 1569, though the house remained in notional operation, being held by commendators until 1602.
The final suppression of the monastery in that year probably relates to the reissuing of King James VI's 1569 charter in 1600.

Of the Priory buildings, said to be 'of wondrous cost and greatness', nothing survives above ground.
 The name Pomarium Flats, for a modern housing scheme near the site of the medieval buildings, recalls the site of the house's orchard.
On 11 May 1559, the Charterhouse and the other religious houses of Perth were attacked and destroyed by Protestant "reformers"; one of the brothers was killed, four others fled abroad, while six monks chose to remain; two of those, the prior Adam Forman and a brother, fled in to foreign Carthusian houses in 1567. Of the four who remained in 1567, one was Adam Stewart, illegitimate son of King James V of Scotland, who for some time styled himself "Prior". King James VI of Scotland granted the buildings and the gardens of the house to the burgh of Perth on 9 August 1569, though the house remained in notional operation, being held by commendators until 1602. The final suppression of the monastery in that year probably relates to the reissuing of King James VI's 1569 charter in 1600.
Of the Priory buildings, said to be 'of wondrous cost and greatness', nothing survives above ground.  The name Pomarium Flats, for a modern housing scheme near the site of the medieval buildings, recalls the site of the house's orchard.
Perth Charterhouse