On March 23, 1876, Goodyear married Ella Portia Conger (1853–1940), of Collins Center, New York.
The family lived at the Charles W. Goodyear House, built in 1903 by architect E.B. Green of Green & Wicks, at 888 Delaware Avenue in Buffalo.
 Together, they had four children, all born in Buffalo:
Anson Conger Goodyear (1877–1964), who married Mary Forman (1879–1973).

Esther Permelia Goodyear (1881–1955), who married Arnold Brooks Watson (b. 1877) in 1910.

Charles Waterhouse Goodyear II (1883–1967), who married Grace Rumsey (1883–1963), sister of Charles Cary Rumsey, in 1908.
They divorced, and in 1935, Charles married Marion Spaulding.

Bradley Goodyear Sr. (
1885–1959), who married Jeanette Bissell (1886–1983).

Goodyear, a member of the Presbyterian Church, held office of trustee of the Buffalo Normal School, was organizing director of the Pan-American Exposition, president of the Buffalo Club (in 1899), trustee to the Buffalo Historical Society, on the board of The Buffalo Fine Arts Academy and a delegate to Syracuse Convention.

Among his close friends were U.S. President Grover Cleveland and Cleveland's Secretary of War Daniel S. Lamont.
He was widely considered instrumental in Cleveland receiving the nomination for President of the United States while Governor of New York.
Goodyear and his wife were the first guests of President Cleveland at the White House.

Goodyear died in Buffalo, New York, on April 16, 1911 and is buried at Forest Lawn Cemetery, Buffalo along with his father, mother, brother, wife, and son.
On March 23, 1876, Goodyear married Ella Portia Conger (1853–1940), of Collins Center, New York. The family lived at the Charles W. Goodyear House, built in 1903 by architect E.B. Green of Green & Wicks, at 888 Delaware Avenue in Buffalo.  Together, they had four children, all born in Buffalo:
Anson Conger Goodyear (1877–1964), who married Mary Forman (1879–1973).
Esther Permelia Goodyear (1881–1955), who married Arnold Brooks Watson (b. 1877) in 1910.
Charles Waterhouse Goodyear II (1883–1967), who married Grace Rumsey (1883–1963), sister of Charles Cary Rumsey, in 1908. They divorced, and in 1935, Charles married Marion Spaulding.
Bradley Goodyear Sr. (1885–1959), who married Jeanette Bissell (1886–1983).
Goodyear, a member of the Presbyterian Church, held office of trustee of the Buffalo Normal School, was organizing director of the Pan-American Exposition, president of the Buffalo Club (in 1899), trustee to the Buffalo Historical Society, on the board of The Buffalo Fine Arts Academy and a delegate to Syracuse Convention.
Among his close friends were U.S. President Grover Cleveland and Cleveland's Secretary of War Daniel S. Lamont. He was widely considered instrumental in Cleveland receiving the nomination for President of the United States while Governor of New York. Goodyear and his wife were the first guests of President Cleveland at the White House.
Goodyear died in Buffalo, New York, on April 16, 1911 and is buried at Forest Lawn Cemetery, Buffalo along with his father, mother, brother, wife, and son.
Charles W. Goodyear