Initially, most routes used buses designed for short journeys that had neither toilet facilities nor luggage space, and each passenger was allowed only one bag.

To commence operations, 1990/91 built 3-axle 94 seat Alexander RH bodied Leyland Olympians were purchased from Hong Kong Citybus.
Stagecoach had previously owned these buses when it owned Citybus from March 1999 until June 2003.

Three-axle Dennis Dragons were allocated to Manchester to Liverpool and Manchester to Leeds services, which ceased operations in 2004.

A number of mid-life Volvo B10M coaches temporarily operated various routes, mainly in the South of England, until sufficient Olympians had been prepared for service.
Gradually, most of these coaches were taken off Megabus work and used by Stagecoach elsewhere.
However, the type made a reappearance at the end of 2005, when they became the mainstays on the services from London to Birmingham and London to Nottingham/Chesterfield.

Newer 'high-frills' articulated coaches, with both toilets and reclining seats, were used for the longer journeys between London and Scotland, but these were replaced early in 2005.
These coaches have since been refurbished and modified to include beds for an Overnight 'Sleeper' service between London and Glasgow started in late 2011, competing with the Caledonian Sleeper train.

In summer 2004, Stagecoach received a batch of Neoplan Skyliners for the Oxford Tube.
This displaced 68-seat five-year-old double deck Jonckheere bodied MAN 24.350 HOCLNR-NL coaches, some of which were transferred to Megabus on cross-border services and on services within Scotland.

Stagecoach ordered another batch of Neoplan Skyliners, which entered service with Megabus in early 2005.
These replaced the articulated coaches used between London and Scotland, and also Leyland Olympians on some other longer distance services.

In October 2006, Stagecoach ordered 45 Plaxton Panther bodied Volvo B12BT 15-metre 65 seat coaches.
The three-axle coaches were the longest rigid vehicles in the UK on their introduction to service in February 2007, and the first of their kind to be built in Britain.

In September 2009, Megabus took delivery of four new Van Hool Astromega double-deck coaches, currently used between London and Scotland via Manchester 
In October 2011, Megabus started an overnight sleeper service with 24 seats and bunks, between London and Glasgow.
In November 2011 it started running daily and has proved to be very popular.
The coaches used were modified Volvo B10M articulated coaches with Jonckheere bodywork.
Despite its popularity, Megabus withdrew this service in 2017.

In early 2013, Megabus introduced new Plaxton Elite i coaches, built upon the Volvo B11RT chassis, into the fleet, running mainly on routes M9, M20 and the 900 (on behalf of Scottish Citylink).

In March and April 2018, 9 former Selkent and East London Alexander Dennis ALX400 bodied Tridents were refurbished by Alexander Dennis is preparation for the new Megasightseeing Tours in London.
Initially, most routes used buses designed for short journeys that had neither toilet facilities nor luggage space, and each passenger was allowed only one bag.
To commence operations, 1990/91 built 3-axle 94 seat Alexander RH bodied Leyland Olympians were purchased from Hong Kong Citybus. Stagecoach had previously owned these buses when it owned Citybus from March 1999 until June 2003.
Three-axle Dennis Dragons were allocated to Manchester to Liverpool and Manchester to Leeds services, which ceased operations in 2004.
A number of mid-life Volvo B10M coaches temporarily operated various routes, mainly in the South of England, until sufficient Olympians had been prepared for service. Gradually, most of these coaches were taken off Megabus work and used by Stagecoach elsewhere. However, the type made a reappearance at the end of 2005, when they became the mainstays on the services from London to Birmingham and London to Nottingham/Chesterfield.
Newer 'high-frills' articulated coaches, with both toilets and reclining seats, were used for the longer journeys between London and Scotland, but these were replaced early in 2005. These coaches have since been refurbished and modified to include beds for an Overnight 'Sleeper' service between London and Glasgow started in late 2011, competing with the Caledonian Sleeper train.
In summer 2004, Stagecoach received a batch of Neoplan Skyliners for the Oxford Tube. This displaced 68-seat five-year-old double deck Jonckheere bodied MAN 24.350 HOCLNR-NL coaches, some of which were transferred to Megabus on cross-border services and on services within Scotland.
Stagecoach ordered another batch of Neoplan Skyliners, which entered service with Megabus in early 2005. These replaced the articulated coaches used between London and Scotland, and also Leyland Olympians on some other longer distance services.
In October 2006, Stagecoach ordered 45 Plaxton Panther bodied Volvo B12BT 15-metre 65 seat coaches. The three-axle coaches were the longest rigid vehicles in the UK on their introduction to service in February 2007, and the first of their kind to be built in Britain.
In September 2009, Megabus took delivery of four new Van Hool Astromega double-deck coaches, currently used between London and Scotland via Manchester 
In October 2011, Megabus started an overnight sleeper service with 24 seats and bunks, between London and Glasgow. In November 2011 it started running daily and has proved to be very popular. The coaches used were modified Volvo B10M articulated coaches with Jonckheere bodywork. Despite its popularity, Megabus withdrew this service in 2017.
In early 2013, Megabus introduced new Plaxton Elite i coaches, built upon the Volvo B11RT chassis, into the fleet, running mainly on routes M9, M20 and the 900 (on behalf of Scottish Citylink).
In March and April 2018, 9 former Selkent and East London Alexander Dennis ALX400 bodied Tridents were refurbished by Alexander Dennis is preparation for the new Megasightseeing Tours in London.
Megabus (Europe)