After the film Flirting (1991), Newton played the slave "Yvette" in the Brad Pitt/Tom Cruise film Interview with the Vampire (1994).
Newton appeared in the Merchant Ivory production of Jefferson in Paris as Sally Hemings, followed by Jonathan Demme's drama Beloved, based on Toni Morrison's novel (1998), in which she played the title character, the ghost of a young slave girl whose mother murders her to save her from slavery.
The film also starred Oprah Winfrey and Danny Glover.
Newton then starred as Nyah Nordoff-Hall, again opposite Cruise, in Mission: Impossible 2.
Her next role was in the low-budget film It Was an Accident, written by her husband, screenwriter Ol Parker.

Between 2003 and 2005, Newton played Makemba "Kem" Likasu, love interest of John Carter on the American television series ER.
She reprised the role for the series finale in 2009.
In 2004, she also appeared in The Chronicles of Riddick and Crash.
Newton won a BAFTA award for Best Supporting Actress in 2006 for her role in Crash.
She played Chris Gardner's wife, Linda Gardner, in The Pursuit of Happyness.
Also in 2006, Newton performed on radio in a pantomime version of Cinderella.

In 2007, Newton co-starred with Eddie Murphy in the comedy Norbit as his love interest, and then opposite Simon Pegg as his ex-girlfriend in the 2008 comedy Run Fatboy Run.
Newton next portrayed US National Security Advisor-turned Secretary of State Condoleezza Rice in W., Oliver Stone's biography of President George W. Bush.
The film was released 17 October 2008.

Newton was an introducer at Wembley Stadium on 7 July 2007, for the UK leg of Live Earth.
She was due to introduce Al Gore to the concert, but he was delayed, leaving Newton to tell jokes in an attempt to entertain the audience.
Newton next portrayed fictional US First Daughter Laura Wilson in 2012, a disaster film directed by Roland Emmerich and released 13 November 2009.

In July 2011, Newton delivered a TED Talk on "Embracing otherness, embracing myself."
She discussed finding her "otherness" as a child growing up in two distinct cultures, and as an actress playing many different selves.
In 2012, she starred alongside Tyler Perry in the romantic drama film Good Deeds.
In 2013, Newton starred in Rogue, the first original drama series for DirecTV's Audience Network.
She left Rogue during the third season.
In 2015, she starred in the US miniseries The Slap.

In 2016, Newton began portraying Maeve Millay in HBO science fiction drama series Westworld, for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series, among other accolades.
In 2017, she served as a narrator for the documentary entitled Bill Cosby: Fall of an American Icon, an exposé on the sexual assault charges laid against Cosby, which aired on BBC One.
Newton appeared as Val in the Star Wars film Solo: A Star Wars Story, which was released in May 2018.
After the film Flirting (1991), Newton played the slave "Yvette" in the Brad Pitt/Tom Cruise film Interview with the Vampire (1994). Newton appeared in the Merchant Ivory production of Jefferson in Paris as Sally Hemings, followed by Jonathan Demme's drama Beloved, based on Toni Morrison's novel (1998), in which she played the title character, the ghost of a young slave girl whose mother murders her to save her from slavery. The film also starred Oprah Winfrey and Danny Glover. Newton then starred as Nyah Nordoff-Hall, again opposite Cruise, in Mission: Impossible 2. Her next role was in the low-budget film It Was an Accident, written by her husband, screenwriter Ol Parker.
Between 2003 and 2005, Newton played Makemba "Kem" Likasu, love interest of John Carter on the American television series ER. She reprised the role for the series finale in 2009. In 2004, she also appeared in The Chronicles of Riddick and Crash. Newton won a BAFTA award for Best Supporting Actress in 2006 for her role in Crash. She played Chris Gardner's wife, Linda Gardner, in The Pursuit of Happyness. Also in 2006, Newton performed on radio in a pantomime version of Cinderella.
In 2007, Newton co-starred with Eddie Murphy in the comedy Norbit as his love interest, and then opposite Simon Pegg as his ex-girlfriend in the 2008 comedy Run Fatboy Run. Newton next portrayed US National Security Advisor-turned Secretary of State Condoleezza Rice in W., Oliver Stone's biography of President George W. Bush. The film was released 17 October 2008.
Newton was an introducer at Wembley Stadium on 7 July 2007, for the UK leg of Live Earth. She was due to introduce Al Gore to the concert, but he was delayed, leaving Newton to tell jokes in an attempt to entertain the audience. Newton next portrayed fictional US First Daughter Laura Wilson in 2012, a disaster film directed by Roland Emmerich and released 13 November 2009.
In July 2011, Newton delivered a TED Talk on "Embracing otherness, embracing myself." She discussed finding her "otherness" as a child growing up in two distinct cultures, and as an actress playing many different selves. In 2012, she starred alongside Tyler Perry in the romantic drama film Good Deeds. In 2013, Newton starred in Rogue, the first original drama series for DirecTV's Audience Network. She left Rogue during the third season. In 2015, she starred in the US miniseries The Slap.
In 2016, Newton began portraying Maeve Millay in HBO science fiction drama series Westworld, for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series, among other accolades. In 2017, she served as a narrator for the documentary entitled Bill Cosby: Fall of an American Icon, an exposé on the sexual assault charges laid against Cosby, which aired on BBC One. Newton appeared as Val in the Star Wars film Solo: A Star Wars Story, which was released in May 2018.
Thandie Newton