The mechanism of deficiency of the interleukin-1–receptor antagonist affects the normal function of IL1RN gene.
The protein produced by IL1RN gene prevents the normal activities of interleukin 1(alpha) and interleukin 1(beta).
Therefore, the pathophysiologic immune and inflammatory responses are nullified.
Interleukin 1 receptor antagonist (IL1RN) has a total of five alleles, of those the  (IL1RN*1) and (IL1RN*2) are the most common as the other alleles are seen less than 5 percent.

IL-1RN binds to the same cell receptors as the inflammatory protein IL-1, and blocks its inflammatory actions.
Without IL-1Ra, the body cannot control systemic inflammation that can be caused by IL-1.
The mechanism of deficiency of the interleukin-1–receptor antagonist affects the normal function of IL1RN gene. The protein produced by IL1RN gene prevents the normal activities of interleukin 1(alpha) and interleukin 1(beta). Therefore, the pathophysiologic immune and inflammatory responses are nullified. Interleukin 1 receptor antagonist (IL1RN) has a total of five alleles, of those the  (IL1RN*1) and (IL1RN*2) are the most common as the other alleles are seen less than 5 percent.
IL-1RN binds to the same cell receptors as the inflammatory protein IL-1, and blocks its inflammatory actions. Without IL-1Ra, the body cannot control systemic inflammation that can be caused by IL-1.
Deficiency of the interleukin-1–receptor antagonist