Saint Aureus of Mainz (5th century), Bishop of Mainz: some of his remains were reinterred in Heiligenstadt and he is the patron saint of the town.

Burchard of Worms (c. 965–20 August 1025), consecrated Bishop of Worms in Heiligenstadt in 1000.

Adolf I of Nassau (1353–1390), Archbishop of Mainz, died in Heiligenstadt.

Athanasius Kircher (1602–1680), Jesuit scholar, taught in Heiligenstadt.

Hadrian Daude (1704–1755), Jesuit theologian, taught in Heiligenstadt.

Friedrich Christian Adolf von Motz (1775–1830), Prussian statesman, was Director of Finance in Heiligenstadt.

Heinrich Heine (1797–1856), poet and journalist, was baptised a Protestant in Heiligenstadt in June 1825.

Johann Carl Fuhlrott (1803–1877), natural historian, taught in Heiligenstadt.

Heinrich Maria Waldmann (1811–1896), theologian and teacher in Heiligenstadt, a representative in the Frankfurt Parliament of 1848/49.

Theodor Storm (1817–1888), author, judge in Heiligenstadt from 1856 to 1864.

Friedrich Wilhelm Grimme (1827–1887), author and botanist, was director of the Catholic gymnasium in Heiligenstadt.

Werner Hagedorn (1831–1894), surgeon, educated in Heiligenstadt.

Anton Thraen (1843–1902), astronomer, educated in Heiligenstadt.

Karl Wisniewski (1844–1904), composer, worked in Heiligenstadt from 1885 on.

Hermann Iseke (1856–1907), poet
Martin Weinrich (1865–1925), Catholic educator and author, educated in Heiligenstadt.

Andreas Huke (1876–1962), politician, worked and lived in Heiligenstadt.

Walter Möllenberg (1879–1951), historian, died in Heiligenstadt
Ludolf Hermann Müller (1882–1959), Protestant Bishop of Saxony, had been a minister in Heiligenstadt.

Karl Paul Haendly (1891–1965), author and politician, died in Heiligenstadt.

Karl Hackethal (1901–1990), politician, educated in Heiligenstadt.

Herbert Haselwander (1910–1940), Nazi district leader in Heiligenstadt.

Erich Gerberding (1921–1986), actor, member of the Heiligenstadt theatre.

Horst Keitel (born 1928), actor, member of the Heiligenstadt theatre from 1946 to 1951.

Rudolf Richwien (born 1928), neurologist, retired to Heiligenstadt.

Johannes Dyba (1929–2000), Bishop of Fulda, educated in Heiligenstadt.

Joachim Meisner (born 1933), Archbishop of Cologne, previously chaplain at St. Egidius' church in Heiligenstadt.

Georg Sterzinsky (born 1936), Archbishop of Berlin, previously chaplain at St. Egidius' church in Heiligenstadt.

Heinz-Josef Durstewitz (born 1945), Catholic dissenter in the GDR, now Provost of Heiligenstadt.

Reinhard Hauke (born 1953), Auxiliary bishop of Erfurt, previously chaplain at St. Egidius' church in Heiligenstadt.

Manfred Grund (born 1955), politician, active in Heiligenstadt.
Saint Aureus of Mainz (5th century), Bishop of Mainz: some of his remains were reinterred in Heiligenstadt and he is the patron saint of the town.
Burchard of Worms (c. 965–20 August 1025), consecrated Bishop of Worms in Heiligenstadt in 1000.
Adolf I of Nassau (1353–1390), Archbishop of Mainz, died in Heiligenstadt.
Athanasius Kircher (1602–1680), Jesuit scholar, taught in Heiligenstadt.
Hadrian Daude (1704–1755), Jesuit theologian, taught in Heiligenstadt.
Friedrich Christian Adolf von Motz (1775–1830), Prussian statesman, was Director of Finance in Heiligenstadt.
Heinrich Heine (1797–1856), poet and journalist, was baptised a Protestant in Heiligenstadt in June 1825.
Johann Carl Fuhlrott (1803–1877), natural historian, taught in Heiligenstadt.
Heinrich Maria Waldmann (1811–1896), theologian and teacher in Heiligenstadt, a representative in the Frankfurt Parliament of 1848/49.
Theodor Storm (1817–1888), author, judge in Heiligenstadt from 1856 to 1864.
Friedrich Wilhelm Grimme (1827–1887), author and botanist, was director of the Catholic gymnasium in Heiligenstadt.
Werner Hagedorn (1831–1894), surgeon, educated in Heiligenstadt.
Anton Thraen (1843–1902), astronomer, educated in Heiligenstadt.
Karl Wisniewski (1844–1904), composer, worked in Heiligenstadt from 1885 on.
Hermann Iseke (1856–1907), poet
Martin Weinrich (1865–1925), Catholic educator and author, educated in Heiligenstadt.
Andreas Huke (1876–1962), politician, worked and lived in Heiligenstadt.
Walter Möllenberg (1879–1951), historian, died in Heiligenstadt
Ludolf Hermann Müller (1882–1959), Protestant Bishop of Saxony, had been a minister in Heiligenstadt.
Karl Paul Haendly (1891–1965), author and politician, died in Heiligenstadt.
Karl Hackethal (1901–1990), politician, educated in Heiligenstadt.
Herbert Haselwander (1910–1940), Nazi district leader in Heiligenstadt.
Erich Gerberding (1921–1986), actor, member of the Heiligenstadt theatre.
Horst Keitel (born 1928), actor, member of the Heiligenstadt theatre from 1946 to 1951.
Rudolf Richwien (born 1928), neurologist, retired to Heiligenstadt.
Johannes Dyba (1929–2000), Bishop of Fulda, educated in Heiligenstadt.
Joachim Meisner (born 1933), Archbishop of Cologne, previously chaplain at St. Egidius' church in Heiligenstadt.
Georg Sterzinsky (born 1936), Archbishop of Berlin, previously chaplain at St. Egidius' church in Heiligenstadt.
Heinz-Josef Durstewitz (born 1945), Catholic dissenter in the GDR, now Provost of Heiligenstadt.
Reinhard Hauke (born 1953), Auxiliary bishop of Erfurt, previously chaplain at St. Egidius' church in Heiligenstadt.
Manfred Grund (born 1955), politician, active in Heiligenstadt.
Heilbad Heiligenstadt