Irsina Cathedral (Cattedrale di Santa Maria Assunta) was built in the 13th century and rebuilt in 1777.
It has a Baroque façade and a Gothic bell tower with mullioned windows.
The interior houses a red marble baptismal font, and a marble statue of Saint Euphemia, the town's patron saint (claimed as the only known sculpture by Andrea Mantegna) and several canvasses of the 18th century Neapolitan school.

Church of the friary of St. Francis (former castle of Frederick II).
Dating to the 12th century, it was rebuilt in the 16th century.
The crypt has 14th-century frescoes of the Umbrian-Sienese school portraying the Redeemer, the Incoronation, the Annunciation, the Crucifixion and the Resurrection.

Church of Maria S.S. del Carmine, housing a 17th-century painting of the Marriage at Cana.

Church of the Madonna della Pieta (1703).
It is located opposite the western side of the walls of the ancient Montepeloso, in an affected area since the eleventh century by the Benedictine monastery of St. Mary of Juso .
Irsina Cathedral (Cattedrale di Santa Maria Assunta) was built in the 13th century and rebuilt in 1777. It has a Baroque façade and a Gothic bell tower with mullioned windows. The interior houses a red marble baptismal font, and a marble statue of Saint Euphemia, the town's patron saint (claimed as the only known sculpture by Andrea Mantegna) and several canvasses of the 18th century Neapolitan school.
Church of the friary of St. Francis (former castle of Frederick II). Dating to the 12th century, it was rebuilt in the 16th century. The crypt has 14th-century frescoes of the Umbrian-Sienese school portraying the Redeemer, the Incoronation, the Annunciation, the Crucifixion and the Resurrection.
Church of Maria S.S. del Carmine, housing a 17th-century painting of the Marriage at Cana.
Church of the Madonna della Pieta (1703). It is located opposite the western side of the walls of the ancient Montepeloso, in an affected area since the eleventh century by the Benedictine monastery of St. Mary of Juso .
Irsina