After returning to Boston 31 March 1942, Gleaves departed 10 May for participation in the Allied landings in Sicily.
After engaging in support and convoy operations in the battle zone, Gleaves and Plunkett accepted the surrender of the Italian garrison on the island of Ustica 5 August 1943, and later landed occupation troops on the island.
She also drove off a group of five enemy E-boats attempting to attack shipping in the harbor of Palermo, Sicily.

As Allied preparations for the invasion of Italy reached a climax, Gleaves bombarded the Italian mainland.
In September 1943 she helped clear the way for the Salerno landing forces.
Following the assault, Gleaves convoyed shipping in the Mediterranean area in support of the drive north from Salerno.

When German air and land forces combined in a determined attempt to stop the landings at Anzio in January 1944, Gleaves was again on hand to lend decisive gunfire support and antiaircraft cover.
In May of that year she attempted to search out and destroy the German submarine U-616 but other ships of the group sank the U-boat.
Survivors from the sunken U-boat were picked up by Gleaves 17 May.
Gleaves next took part in the invasion of southern France in August 1944.
She escorted the Rangers in their initial landings; bombarded shore installations in support of the main assault; and screened heavier units of the fleet off shore.

On 1 October, Army Cub pilots discovered German MAS boats in the harbor at San Remo, Italy.
A determined bombardment in the face of heavy return fire brought about the destruction of at least three of those craft and demolished the boat repair facilities and other harbor installations around the port.
Gleaves also found time to destroy at least one 88 mm (3 in) battery which had proven a hazard during the bombardment.
The following day, assisted by aircraft from USS Brooklyn, she bombarded shore establishments, battery positions and shipping in the harbor of Oneglia, Italy, obtaining hits on two large enemy cargo ships, destroying one coast defense battery and one anti-aircraft battery near the harbor.
During that action Gleaves received some of the few battle scars of her career when an 88-millimeter shell landed close aboard and perforated her hull with shrapnel splinters.

During the night, while patrolling off San Remo, Gleaves' radar spotted three enemy vessels moving down the coast.
Unassisted she drove in at them in spite of reported mine fields and succeed at destroying one, driving the other two to shelter.
Later during that night the remaining two were again detected trying to reach San Remo.
Again, Gleaves went into the attack and this time destroyed a second vessel in the group and drove the third back to Genoa, probably in a damaged condition.

While returning to her station off San Remo she went to battle stations for the third time that night as she was made the object of an attack by at least five suicide-manned explosive motor boats.
Judicious application of gun-fire, depth charges and violent maneuvering at maximum speed brought her safely through that attack, leaving four of the craft sunk in her wake.
The following morning, upon returning to the area she captured the fifth boat intact with two boat operators aboard.
Insofar as it is known, that was the first craft of that type captured from the Germans and it provided valuable tactical information to the Allied forces in the area.

In December 1944, Gleaves was assigned as fire support ship near Allied positions on the Franco-Italian frontier, and performed this duty until sailing for the United States in February 1945.
After a period of outfitting at New York and training activities in the Caribbean, she departed 30 June 1945 from Guantanamo Bay, Cuba, for the Pacific, arriving at Pearl Harbor 4 August.
While completing her training period in Hawaiian waters, the war came to an abrupt end.
However, Gleaves proceeded westward with the outbound occupation convoys and participated in the occupation of Nagasaki in September 1945.
She was then engaged in convoy work and commended for her outstan
After returning to Boston 31 March 1942, Gleaves departed 10 May for participation in the Allied landings in Sicily. After engaging in support and convoy operations in the battle zone, Gleaves and Plunkett accepted the surrender of the Italian garrison on the island of Ustica 5 August 1943, and later landed occupation troops on the island. She also drove off a group of five enemy E-boats attempting to attack shipping in the harbor of Palermo, Sicily.
As Allied preparations for the invasion of Italy reached a climax, Gleaves bombarded the Italian mainland. In September 1943 she helped clear the way for the Salerno landing forces. Following the assault, Gleaves convoyed shipping in the Mediterranean area in support of the drive north from Salerno.
When German air and land forces combined in a determined attempt to stop the landings at Anzio in January 1944, Gleaves was again on hand to lend decisive gunfire support and antiaircraft cover. In May of that year she attempted to search out and destroy the German submarine U-616 but other ships of the group sank the U-boat. Survivors from the sunken U-boat were picked up by Gleaves 17 May.
Gleaves next took part in the invasion of southern France in August 1944. She escorted the Rangers in their initial landings; bombarded shore installations in support of the main assault; and screened heavier units of the fleet off shore.
On 1 October, Army Cub pilots discovered German MAS boats in the harbor at San Remo, Italy. A determined bombardment in the face of heavy return fire brought about the destruction of at least three of those craft and demolished the boat repair facilities and other harbor installations around the port. Gleaves also found time to destroy at least one 88 mm (3 in) battery which had proven a hazard during the bombardment. The following day, assisted by aircraft from USS Brooklyn, she bombarded shore establishments, battery positions and shipping in the harbor of Oneglia, Italy, obtaining hits on two large enemy cargo ships, destroying one coast defense battery and one anti-aircraft battery near the harbor. During that action Gleaves received some of the few battle scars of her career when an 88-millimeter shell landed close aboard and perforated her hull with shrapnel splinters.
During the night, while patrolling off San Remo, Gleaves' radar spotted three enemy vessels moving down the coast. Unassisted she drove in at them in spite of reported mine fields and succeed at destroying one, driving the other two to shelter. Later during that night the remaining two were again detected trying to reach San Remo. Again, Gleaves went into the attack and this time destroyed a second vessel in the group and drove the third back to Genoa, probably in a damaged condition.
While returning to her station off San Remo she went to battle stations for the third time that night as she was made the object of an attack by at least five suicide-manned explosive motor boats. Judicious application of gun-fire, depth charges and violent maneuvering at maximum speed brought her safely through that attack, leaving four of the craft sunk in her wake. The following morning, upon returning to the area she captured the fifth boat intact with two boat operators aboard. Insofar as it is known, that was the first craft of that type captured from the Germans and it provided valuable tactical information to the Allied forces in the area.
In December 1944, Gleaves was assigned as fire support ship near Allied positions on the Franco-Italian frontier, and performed this duty until sailing for the United States in February 1945. After a period of outfitting at New York and training activities in the Caribbean, she departed 30 June 1945 from Guantanamo Bay, Cuba, for the Pacific, arriving at Pearl Harbor 4 August. While completing her training period in Hawaiian waters, the war came to an abrupt end. However, Gleaves proceeded westward with the outbound occupation convoys and participated in the occupation of Nagasaki in September 1945. She was then engaged in convoy work and commended for her outstan
USS Gleaves (DD-423)