On March 28, 2008 Casey announced his endorsement of frontrunning candidate Senator Barack Obama in the Democratic Party presidential primary.
The Pennsylvania Report said that he "struck gold" by endorsing Obama early in the 2008 Democratic presidential primary, a move that gave him "inside access to the halls of the White House".
Casey campaigned across Pennsylvania in support of Obama's candidacy in the months leading up to the primary in that state; they bowled together at Pleasant Valley Lanes in Altoona.

Casey has been described as an "even-keeled moderate, not only in tone but in policy", but since Donald Trump entered the White House, Casey has developed a "new, saltier social media prowess".
Casey's outspoken opposition to many of Trump's actions has prompted one local media outlet to describe his new strategy before his 2018 re-election campaign as: "Oppose Trump every chance he gets."

On February 18, 2018, speaking to John Catsimatidis on New York radio station WNYM Bob Casey Jr. issued a warning to special counsel Robert Mueller not to deliver a report on his findings in the Russian interference in the 2016 United States elections investigation, too near to the 2018 midterm elections.
While saying he could not "make any assumptions about where the Mueller investigation is going", he stated that he "would recommend Mueller not release a report on his findings near the midterms", because it would "distract from elections or cause people to question the election's integrity".
On March 28, 2008 Casey announced his endorsement of frontrunning candidate Senator Barack Obama in the Democratic Party presidential primary. The Pennsylvania Report said that he "struck gold" by endorsing Obama early in the 2008 Democratic presidential primary, a move that gave him "inside access to the halls of the White House". Casey campaigned across Pennsylvania in support of Obama's candidacy in the months leading up to the primary in that state; they bowled together at Pleasant Valley Lanes in Altoona.
Casey has been described as an "even-keeled moderate, not only in tone but in policy", but since Donald Trump entered the White House, Casey has developed a "new, saltier social media prowess". Casey's outspoken opposition to many of Trump's actions has prompted one local media outlet to describe his new strategy before his 2018 re-election campaign as: "Oppose Trump every chance he gets."
On February 18, 2018, speaking to John Catsimatidis on New York radio station WNYM Bob Casey Jr. issued a warning to special counsel Robert Mueller not to deliver a report on his findings in the Russian interference in the 2016 United States elections investigation, too near to the 2018 midterm elections. While saying he could not "make any assumptions about where the Mueller investigation is going", he stated that he "would recommend Mueller not release a report on his findings near the midterms", because it would "distract from elections or cause people to question the election's integrity".
Bob Casey Jr.