On 18 July 2012, Verratti signed a five-year contract with Paris Saint-Germain in Ligue 1.
On 2 September 2012, Verratti made his competitive debut for PSG in an away Ligue 1 match against Lille.
Twelve days later, he  assisted Javier Pastore's opening goal in his first competitive appearance at the Parc des Princes, a 2–0 Ligue 1 defeat of Toulouse.

On 18 September 2012, he made his UEFA Champions League debut in a 4–1 Group A defeat of Dynamo Kyiv.
He ended his first season in the French capital by winning the 2012–13 Ligue 1 title.
On 20 August 2013, Verratti signed a one-year extension to his contract with PSG, keeping him at the club until 2018.

Verratti's second season with PSG was even more successful than the first as the team retained its Ligue 1 title and won the Coupe de la Ligue and the
2013 Trophée des Champions.
Verratti was named as the Ligue 1 Young Player of the Year and included in the Ligue 1 Team of the Year for 2013–14.

On 30 September 2014, Verratti scored his first competitive goal for PSG, a header in a 3–2 home win over Barcelona in the group stage of the Champions League.
On 18 January 2015, Verratti scored his first goal in Ligue 1, in a 4–2 home win over Evian.

In August 2016, Verratti signed a 3-year extension to his contract, keeping him at the club until 2021.

On 6 March 2018, Verratti was sent off after acquiring a second yellow card in the second leg of the Champions League Round of 16 fixture against the eventual champions Real Madrid.
Real Madrid went on to win the game 2–1 and eliminated PSG with an aggregate score of 5–2.

On 3 April 2019, Verratti scored the opening goal from a Kylian Mbappé assist in a 3–0 home win over Nantes in the Coupe de France semi-finals, which allowed PSG to advance to the final of the competition; during the same match, he also provided an assist for his team's final goal, which was scored by Dani Alves.
This goal was Verratti's first of the 2018–19 season for PSG, and also his first goal ever in the competition.

Following PSG's 2–1 victory over Rennes in the 2019 Trophée des Champions on 3 August, Verratti became the player with the most titles with the club, with 22 trophies in total (six Ligue 1 titles, four Coupe de France titles, five Coupe de la Ligue titles, and seven Trophée des Champions titles).
In October, he signed a three–year contract extension with the club, which would tie him to PSG until June 2024.
On 12 January 2020, Verratti made his 300th appearance for PSG in a 3–3 home draw against Monaco in Ligue 1.
On 18 February, he became the club's all-time appearance holder in the Champions League, when he made his 58th appearance in the competition in a 2–1 away loss in the first leg of their round of 16 draw against Borussia Dortmund, overtaking the previous record holder Paul Le Guen at 57.
In April, PSG were assigned the 2019–20 Ligue 1 title after the season was ended prematurely due to the outbreak of the COVID-19 pandemic; at the time of the League's suspension, PSG were in first place, with a twelve–point lead over second–placed Marseille.
This was Verratti's record seventh Ligue 1 title with the club, which saw him equal the all–time individual record of most Ligue 1 title victories, along with his club teammate Thiago Silva, which was jointly held by Hervé Revelli and Jean-Michel Larqué of Saint-Étienne, as well as Grégory Coupet, Juninho and Sidney Govou of Lyon.
PSG went on to win a domestic treble, but lost out in the Champions League final 1–0 to Bayern Munich on 23 August; Verratti made a substitute appearance during the match.
On 18 July 2012, Verratti signed a five-year contract with Paris Saint-Germain in Ligue 1. On 2 September 2012, Verratti made his competitive debut for PSG in an away Ligue 1 match against Lille. Twelve days later, he  assisted Javier Pastore's opening goal in his first competitive appearance at the Parc des Princes, a 2–0 Ligue 1 defeat of Toulouse.
On 18 September 2012, he made his UEFA Champions League debut in a 4–1 Group A defeat of Dynamo Kyiv. He ended his first season in the French capital by winning the 2012–13 Ligue 1 title. On 20 August 2013, Verratti signed a one-year extension to his contract with PSG, keeping him at the club until 2018.
Verratti's second season with PSG was even more successful than the first as the team retained its Ligue 1 title and won the Coupe de la Ligue and the
2013 Trophée des Champions. Verratti was named as the Ligue 1 Young Player of the Year and included in the Ligue 1 Team of the Year for 2013–14.
On 30 September 2014, Verratti scored his first competitive goal for PSG, a header in a 3–2 home win over Barcelona in the group stage of the Champions League. On 18 January 2015, Verratti scored his first goal in Ligue 1, in a 4–2 home win over Evian.
In August 2016, Verratti signed a 3-year extension to his contract, keeping him at the club until 2021.
On 6 March 2018, Verratti was sent off after acquiring a second yellow card in the second leg of the Champions League Round of 16 fixture against the eventual champions Real Madrid. Real Madrid went on to win the game 2–1 and eliminated PSG with an aggregate score of 5–2.
On 3 April 2019, Verratti scored the opening goal from a Kylian Mbappé assist in a 3–0 home win over Nantes in the Coupe de France semi-finals, which allowed PSG to advance to the final of the competition; during the same match, he also provided an assist for his team's final goal, which was scored by Dani Alves. This goal was Verratti's first of the 2018–19 season for PSG, and also his first goal ever in the competition.
Following PSG's 2–1 victory over Rennes in the 2019 Trophée des Champions on 3 August, Verratti became the player with the most titles with the club, with 22 trophies in total (six Ligue 1 titles, four Coupe de France titles, five Coupe de la Ligue titles, and seven Trophée des Champions titles). In October, he signed a three–year contract extension with the club, which would tie him to PSG until June 2024. On 12 January 2020, Verratti made his 300th appearance for PSG in a 3–3 home draw against Monaco in Ligue 1. On 18 February, he became the club's all-time appearance holder in the Champions League, when he made his 58th appearance in the competition in a 2–1 away loss in the first leg of their round of 16 draw against Borussia Dortmund, overtaking the previous record holder Paul Le Guen at 57. In April, PSG were assigned the 2019–20 Ligue 1 title after the season was ended prematurely due to the outbreak of the COVID-19 pandemic; at the time of the League's suspension, PSG were in first place, with a twelve–point lead over second–placed Marseille. This was Verratti's record seventh Ligue 1 title with the club, which saw him equal the all–time individual record of most Ligue 1 title victories, along with his club teammate Thiago Silva, which was jointly held by Hervé Revelli and Jean-Michel Larqué of Saint-Étienne, as well as Grégory Coupet, Juninho and Sidney Govou of Lyon. PSG went on to win a domestic treble, but lost out in the Champions League final 1–0 to Bayern Munich on 23 August; Verratti made a substitute appearance during the match.
Marco Verratti