The parish of Mellieħa was first established in the 15th century or earlier, but in later centuries the village ceased to be a parish since the settlement was prone to attacks from the Barbary pirates and it was abandoned.
The Sanctuary of Our Lady of Mellieħa remained an important shrine, and after the corsair threat had diminished the village began to grow once again.
The parish was reestablished in 1844.

Construction of the parish church began in 1881, and the first stone was blessed by parish priest Francis Maria Magri on 5 September 1883.
The limestone used to build the church was obtained from a quarry at l-Aħrax tal-Mellieħa, and the local population helped in transporting the building materials to the construction site.
The church was blessed by Bishop Pietro Pace on 5 September 1897 and construction lasted until 1898.

Between 1920 and 1940, the church's bell towers and dome were completed, and five bells were purchased from Milan.
The building was consecrated by Bishop Mauro Caruana on 18 February 1930.
The interior was embellished with a number of paintings, including works by the Maltese painters Giuseppe Calì and Lazzaro Pisani.
The parish of Mellieħa was first established in the 15th century or earlier, but in later centuries the village ceased to be a parish since the settlement was prone to attacks from the Barbary pirates and it was abandoned. The Sanctuary of Our Lady of Mellieħa remained an important shrine, and after the corsair threat had diminished the village began to grow once again. The parish was reestablished in 1844.
Construction of the parish church began in 1881, and the first stone was blessed by parish priest Francis Maria Magri on 5 September 1883. The limestone used to build the church was obtained from a quarry at l-Aħrax tal-Mellieħa, and the local population helped in transporting the building materials to the construction site. The church was blessed by Bishop Pietro Pace on 5 September 1897 and construction lasted until 1898.
Between 1920 and 1940, the church's bell towers and dome were completed, and five bells were purchased from Milan. The building was consecrated by Bishop Mauro Caruana on 18 February 1930. The interior was embellished with a number of paintings, including works by the Maltese painters Giuseppe Calì and Lazzaro Pisani.
Parish Church of the Nativity of the Virgin Mary, Mellieħa