On 21 January 2011, Georg Friedrich announced his engagement to Princess Sophie of Isenburg (born 7 March 1978), whose father, Prince of Isenberg, is head of the mediatized Isenberg line of Princes of the Holy Roman Empire.
Princess Sophie studied business administration in Freiburg and Berlin and at the time of their engagement, worked at a firm that offered consulting services for nonprofit business.
The civil wedding took place in Potsdam on 25 August 2011, and the ecumenical religious wedding took place at the Church of Peace in Potsdam on 27 August 2011, in commemoration of the 950th anniversary of the founding of the House of Hohenzollern.
The religious wedding was also broadcast live by local public television.
The dinner, which many members of German and European royal families attended, was held in the Orangery Palace at Sanssouci Park.

As a Protestant descendant of Queen Victoria, Georg Friedrich was in the line of succession to the British throne from his birth until his marriage in 2011.
 As he married a Roman Catholic, according to the Act of Settlement 1701, he was thus debarred from the British line of succession until the implementation in 2015 of the Succession to the Crown Act 2013, which restored any succession rights to British dynasts who had earlier forfeited them to marry Roman Catholics.
Georg Friedrich is currently 170th in line to the British throne.

On 20 January 2013, Georg Friedrich's wife, Sophie, gave birth to twin sons in Bremen, Carl Friedrich Franz Alexander and Louis Ferdinand Christian Albrecht.
Carl Friedrich, the elder of the two, is his father’s heir apparent.
Their third child, Emma Marie Charlotte Sofia, was born on 2 April 2015.
On 17 November 2016, Sophie gave birth to Heinrich Albert Johann Georg , their fourth child.
On 21 January 2011, Georg Friedrich announced his engagement to Princess Sophie of Isenburg (born 7 March 1978), whose father, Prince of Isenberg, is head of the mediatized Isenberg line of Princes of the Holy Roman Empire. Princess Sophie studied business administration in Freiburg and Berlin and at the time of their engagement, worked at a firm that offered consulting services for nonprofit business. The civil wedding took place in Potsdam on 25 August 2011, and the ecumenical religious wedding took place at the Church of Peace in Potsdam on 27 August 2011, in commemoration of the 950th anniversary of the founding of the House of Hohenzollern. The religious wedding was also broadcast live by local public television. The dinner, which many members of German and European royal families attended, was held in the Orangery Palace at Sanssouci Park.
As a Protestant descendant of Queen Victoria, Georg Friedrich was in the line of succession to the British throne from his birth until his marriage in 2011.  As he married a Roman Catholic, according to the Act of Settlement 1701, he was thus debarred from the British line of succession until the implementation in 2015 of the Succession to the Crown Act 2013, which restored any succession rights to British dynasts who had earlier forfeited them to marry Roman Catholics. Georg Friedrich is currently 170th in line to the British throne.
On 20 January 2013, Georg Friedrich's wife, Sophie, gave birth to twin sons in Bremen, Carl Friedrich Franz Alexander and Louis Ferdinand Christian Albrecht. Carl Friedrich, the elder of the two, is his father’s heir apparent. Their third child, Emma Marie Charlotte Sofia, was born on 2 April 2015. On 17 November 2016, Sophie gave birth to Heinrich Albert Johann Georg , their fourth child.
Georg Friedrich, Prince of Prussia