Harris played for the Cleveland Cavaliers in the NBA Summer League in 2010.
He saw limited action due to the same ankle injury that impaired his draft status.
After being an undrafted player from Michigan for about 3​¹⁄₂ months, Harris joined the Cleveland Cavaliers with a #6 jersey number as a non-guaranteed free agent member of the 20-man preseason roster.
Harris made the final roster.
Me made his debut on October 29 against the Toronto Raptors in which he scored 8 points.
Harris' agent is Henry Thomas.
After compiling a 7–14 record in the first 21 games, head coach Byron Scott shuffled the lineup on December 8, and Harris played twenty-one minutes that night.

On December 29, Harris made his first start when Mo Williams was recovering from an injury and Harris earned the surprise start instead of Ramon Sessions, scoring 8 points.
In his fourth start on January 7 against the Golden State, Harris posted his first double-double with career highs of 16 points and 10 rebounds and added 3 steals and 4 assists, too.
Then, on January 9, he posted a new career-high 27 points against the Phoenix Suns.
With the return of Daniel Gibson and Anthony Parker to the lineup he saw little action until February 23.
Harris played for the Cleveland Cavaliers in the NBA Summer League in 2010. He saw limited action due to the same ankle injury that impaired his draft status. After being an undrafted player from Michigan for about 3​¹⁄₂ months, Harris joined the Cleveland Cavaliers with a #6 jersey number as a non-guaranteed free agent member of the 20-man preseason roster. Harris made the final roster. Me made his debut on October 29 against the Toronto Raptors in which he scored 8 points. Harris' agent is Henry Thomas. After compiling a 7–14 record in the first 21 games, head coach Byron Scott shuffled the lineup on December 8, and Harris played twenty-one minutes that night.
On December 29, Harris made his first start when Mo Williams was recovering from an injury and Harris earned the surprise start instead of Ramon Sessions, scoring 8 points. In his fourth start on January 7 against the Golden State, Harris posted his first double-double with career highs of 16 points and 10 rebounds and added 3 steals and 4 assists, too. Then, on January 9, he posted a new career-high 27 points against the Phoenix Suns. With the return of Daniel Gibson and Anthony Parker to the lineup he saw little action until February 23.
Manny Harris