The Ottoman Railway Company chose to start their line in the neighborhood of Alsancak, near the docks.
The original station consisted of a small building with a few tracks and a small depot.
The station opened on 30 October 1858 when the railway reached Gaziemir and Seydiköy.
Passenger traffic was low and the few freight trains that operated, unloaded at Kemer.
The railway reached Aydın in 1866 and the ORC opened the whole line on 1 July 1866.
When this line opened, freight traffic was too heavy for Kemer to handle and the ORC needed a larger depot.
More tracks were added, maintenance depots, train sheds and freight depots were built as well as the Alsancak dock being considerably extended.
Also a lot of rich foreign and Ottoman business leviathans lived in İzmir, mainly in Bornova, Şirinyer and Buca.
The railway could help them commute to work in Alsancak and back to their homes.
Passenger traffic increased once the Şirinyer-Buca branch was opened, in 1870 and a new station was needed to be built for these rich families.
In 1871 a new, bigger station with a clock tower was opened.
This clock tower became the first in İzmir.
Today, this building is the headquarters of District 3.

In 1890s a tram line was opened from the dock in Pasaport to Alsancak station, traveling up the Kordon waterfront.
This line was connected to the tracks at the station and passengers would board horse-pulled trams from Pasaport to Alsancak station to board intercity trains in the day.
At night freight trains would transport freight to Pasaport pier, to reduce the congestion in the port of Alsancak.
With the opening of this tram line traffic increased even more and the existing freight depots were moved to the Alsancak docks.

The railway also changed the economy of İzmir completely.
In the early 1900s, gas lamps were added to the city streets to replace the ones that operated with coal.
With this, a power plant was added next to the station and tracks were extended through the station to the docks.
The Ottoman Empire sided with Austria-Hungary and the German Empire.
During the war the Ottoman Railway Company was taken from the English and operated by the Ottoman government.
The Ottoman Empire eventually lost the war in 1920 and the Allies started to occupy Anatolia.
The railway still operated but traffic decreased greatly.
The station was miraculously unharmed during the Great Fire of Smyrna in 1922.
Control of the line was handed back to the ORC on 6 November 1922, when the Ottoman Empire officially collapsed.

The Allied forces eventually left Anatolia after the Turkish Independence War and the Turkish Republic formed.
The Ottoman Railway Company continued to operate under its concession by the Ottoman Empire.
Traffic increased steadily and a new locomotive shed was built in 1923.
In 1927 a railway museum opened in the station.
Once the concession ended in 1935, the Turkish State Railways (1927) agreed to buy the ORC for £1,825,840.
On 1 June 1935 the State Railways absorbed the ORC.
The Ottoman Railway Company chose to start their line in the neighborhood of Alsancak, near the docks. The original station consisted of a small building with a few tracks and a small depot. The station opened on 30 October 1858 when the railway reached Gaziemir and Seydiköy. Passenger traffic was low and the few freight trains that operated, unloaded at Kemer. The railway reached Aydın in 1866 and the ORC opened the whole line on 1 July 1866. When this line opened, freight traffic was too heavy for Kemer to handle and the ORC needed a larger depot. More tracks were added, maintenance depots, train sheds and freight depots were built as well as the Alsancak dock being considerably extended. Also a lot of rich foreign and Ottoman business leviathans lived in İzmir, mainly in Bornova, Şirinyer and Buca. The railway could help them commute to work in Alsancak and back to their homes. Passenger traffic increased once the Şirinyer-Buca branch was opened, in 1870 and a new station was needed to be built for these rich families. In 1871 a new, bigger station with a clock tower was opened. This clock tower became the first in İzmir. Today, this building is the headquarters of District 3.
In 1890s a tram line was opened from the dock in Pasaport to Alsancak station, traveling up the Kordon waterfront. This line was connected to the tracks at the station and passengers would board horse-pulled trams from Pasaport to Alsancak station to board intercity trains in the day. At night freight trains would transport freight to Pasaport pier, to reduce the congestion in the port of Alsancak. With the opening of this tram line traffic increased even more and the existing freight depots were moved to the Alsancak docks.
The railway also changed the economy of İzmir completely. In the early 1900s, gas lamps were added to the city streets to replace the ones that operated with coal. With this, a power plant was added next to the station and tracks were extended through the station to the docks. The Ottoman Empire sided with Austria-Hungary and the German Empire. During the war the Ottoman Railway Company was taken from the English and operated by the Ottoman government. The Ottoman Empire eventually lost the war in 1920 and the Allies started to occupy Anatolia. The railway still operated but traffic decreased greatly. The station was miraculously unharmed during the Great Fire of Smyrna in 1922. Control of the line was handed back to the ORC on 6 November 1922, when the Ottoman Empire officially collapsed.
The Allied forces eventually left Anatolia after the Turkish Independence War and the Turkish Republic formed. The Ottoman Railway Company continued to operate under its concession by the Ottoman Empire. Traffic increased steadily and a new locomotive shed was built in 1923. In 1927 a railway museum opened in the station. Once the concession ended in 1935, the Turkish State Railways (1927) agreed to buy the ORC for £1,825,840. On 1 June 1935 the State Railways absorbed the ORC.
Alsancak railway station