For the Samoyeds in the veterinary literature several breed-specific hereditary diseases are described:
Diabetes mellitus similar but not identical to human Type I (insulin deficiency): The disease occurs in middle-aged Samoyeds, the mean age at diagnosis is seven years.
The cause is a chronic inflammation of the pancreas and / or autoimmune destruction of beta cells of islets of Langerhans.
Moreover, in affected dogs autoantibodies were found to insulin.
Currently, several genetic markers are discussed as possible causes.

Progressive retinal atrophy (PRA) caused by a frameshift mutation in the RPRG locus of the X chromosome.
The disease leads to a slowly progressive loss of vision, which eventually leads to blindness.
The first symptoms appear between two and five years of age.
The disease corresponds to the X-linked PRA type 3 in humans.

Short legs in conjunction with eye abnormalities: Due to a genetic defect at the COL2A1 locus occurs on disproportionate dwarfism with short limbs in connection with cataracts, malformations of the retina and / or retinal detachment, liquefaction of the vitreous and a persistent hyaloid artery.
The malformations of the retina are dominant (i.e. before coming in heterozygous dogs); the other symptoms are recessive, so they only come to expression in homozygous affected dogs.
A connection with Opticin is not.

Pulmonary stenosis occurs more frequently in Samoyeds in comparison with other breeds.
The disease can cause shortness of breath, cardiac arrhythmias and tiring on motion and increases the risk of congestive heart failure.

Hip dysplasia is also a concern for Samoyeds.

The breed can also be affected by sebaceous adenitis, an uncommon idiopathic autoimmune skin disease.
For the Samoyeds in the veterinary literature several breed-specific hereditary diseases are described:
Diabetes mellitus similar but not identical to human Type I (insulin deficiency): The disease occurs in middle-aged Samoyeds, the mean age at diagnosis is seven years. The cause is a chronic inflammation of the pancreas and / or autoimmune destruction of beta cells of islets of Langerhans. Moreover, in affected dogs autoantibodies were found to insulin. Currently, several genetic markers are discussed as possible causes.
Progressive retinal atrophy (PRA) caused by a frameshift mutation in the RPRG locus of the X chromosome. The disease leads to a slowly progressive loss of vision, which eventually leads to blindness. The first symptoms appear between two and five years of age. The disease corresponds to the X-linked PRA type 3 in humans.
Short legs in conjunction with eye abnormalities: Due to a genetic defect at the COL2A1 locus occurs on disproportionate dwarfism with short limbs in connection with cataracts, malformations of the retina and / or retinal detachment, liquefaction of the vitreous and a persistent hyaloid artery. The malformations of the retina are dominant (i.e. before coming in heterozygous dogs); the other symptoms are recessive, so they only come to expression in homozygous affected dogs. A connection with Opticin is not.
Pulmonary stenosis occurs more frequently in Samoyeds in comparison with other breeds. The disease can cause shortness of breath, cardiac arrhythmias and tiring on motion and increases the risk of congestive heart failure.
Hip dysplasia is also a concern for Samoyeds.
The breed can also be affected by sebaceous adenitis, an uncommon idiopathic autoimmune skin disease.
Samoyed (dog)