Charles married the rich, beautiful and ambitious Infanta Beatrice of Portugal (1504–1538), daughter of the richest monarch in Europe at the time Manuel I of Portugal and Maria of Aragon.
Beatrice was both first cousin and sister-in-law of the Charles V, Holy Roman Emperor.
They had nine children, but only one child, Emmanuel Philibert, would reach adulthood:
Adriano Giovanni Amadeo, Prince of Piedmont (19 November 1522 – 10 January 1523)
Ludovico, Prince of Piedmont (4 December 1523 – 25 November 1536)
Emmanuel Philibert, Duke of Savoy (8 July 1528 – 30 August 1580), married Marguerite, Duchess of Berry, sister of Henri II, King of France
Caterina (25 November 1529-May 1536)
Maria (12 June 1530 – 1531)
Isabella (May 1532 – 24 September 1533)
Emanuele (May 1533; died young)
Emanuele (May 1534; died young)
Giovanni (3 December 1537 – 8 January 1538)
Charles married the rich, beautiful and ambitious Infanta Beatrice of Portugal (1504–1538), daughter of the richest monarch in Europe at the time Manuel I of Portugal and Maria of Aragon. Beatrice was both first cousin and sister-in-law of the Charles V, Holy Roman Emperor. They had nine children, but only one child, Emmanuel Philibert, would reach adulthood:
Adriano Giovanni Amadeo, Prince of Piedmont (19 November 1522 – 10 January 1523)
Ludovico, Prince of Piedmont (4 December 1523 – 25 November 1536)
Emmanuel Philibert, Duke of Savoy (8 July 1528 – 30 August 1580), married Marguerite, Duchess of Berry, sister of Henri II, King of France
Caterina (25 November 1529-May 1536)
Maria (12 June 1530 – 1531)
Isabella (May 1532 – 24 September 1533)
Emanuele (May 1533; died young)
Emanuele (May 1534; died young)
Giovanni (3 December 1537 – 8 January 1538)
Charles III, Duke of Savoy