Henderson was drafted by the New Orleans Saints in the second round with the 50th pick of the 2004 NFL Draft.

Henderson benefited from the regime change in New Orleans after his rookie year, as the 2006 season saw Aaron Brooks give way to Drew Brees at quarterback and Sean Payton replace Jim Haslett as head coach.
His statistics improved over those of his rookie season — most notably in receptions (22 vs. 32), total yards (343 vs. 745), yards per catch (15.6 vs. 23.3), longest catch (66 vs. 76), and touchdowns (3 vs. 5).

On November 5, 2006, Devery had his best day as a professional in a game against the Tampa Bay Buccaneers, catching 3 passes for 111 yards and 2 touchdowns.
Henderson had 158 receiving yards on 5 catches, including a 76-yard touchdown, against the Atlanta Falcons on November 26, 2006.
On December 10, 2006, Henderson caught two passes from Drew Brees for 92 yards and one touchdown, as the Saints defeated the Dallas Cowboys 42–17 on NBC Sunday Night Football.

On March 2, 2009, Henderson re-signed with the Saints.
The Saints went to the Super Bowl that year and Henderson had 7 catches for 63 yards en route to the Saints defeating the Indianapolis Colts in Super Bowl XLIV.

On September 18, 2011, Henderson had a touchdown catch for 79 yards.
On October 8, 2012, he caught a touchdown pass from Drew Brees to break Johnny Unitas's record of 47 straight games with a touchdown pass in the Saints' 31-24 win over the San Diego Chargers.

As of Week 17 of the 2012 NFL Season, Henderson averages nearly 18 yards per catch (17.9625), which is the highest among all active receivers for yards per catch with 200+ catches.

After the Saints' 2012 season, Henderson became a free agent.

As of 2019 he is still the #6 All-Time career Receiving Yards Leader in Saints Franchise History with 4377 yards.
Henderson was drafted by the New Orleans Saints in the second round with the 50th pick of the 2004 NFL Draft.
Henderson benefited from the regime change in New Orleans after his rookie year, as the 2006 season saw Aaron Brooks give way to Drew Brees at quarterback and Sean Payton replace Jim Haslett as head coach. His statistics improved over those of his rookie season — most notably in receptions (22 vs. 32), total yards (343 vs. 745), yards per catch (15.6 vs. 23.3), longest catch (66 vs. 76), and touchdowns (3 vs. 5).
On November 5, 2006, Devery had his best day as a professional in a game against the Tampa Bay Buccaneers, catching 3 passes for 111 yards and 2 touchdowns. Henderson had 158 receiving yards on 5 catches, including a 76-yard touchdown, against the Atlanta Falcons on November 26, 2006. On December 10, 2006, Henderson caught two passes from Drew Brees for 92 yards and one touchdown, as the Saints defeated the Dallas Cowboys 42–17 on NBC Sunday Night Football.
On March 2, 2009, Henderson re-signed with the Saints. The Saints went to the Super Bowl that year and Henderson had 7 catches for 63 yards en route to the Saints defeating the Indianapolis Colts in Super Bowl XLIV.
On September 18, 2011, Henderson had a touchdown catch for 79 yards. On October 8, 2012, he caught a touchdown pass from Drew Brees to break Johnny Unitas's record of 47 straight games with a touchdown pass in the Saints' 31-24 win over the San Diego Chargers.
As of Week 17 of the 2012 NFL Season, Henderson averages nearly 18 yards per catch (17.9625), which is the highest among all active receivers for yards per catch with 200+ catches.
After the Saints' 2012 season, Henderson became a free agent.
As of 2019 he is still the #6 All-Time career Receiving Yards Leader in Saints Franchise History with 4377 yards.
Devery Henderson