On November 25, 2015, Griffin recorded season-highs with 40 points and 12 rebounds in a loss to the Utah Jazz, with the Clippers dropping to 7–8 after starting the season 4–0.
On December 26, he was ruled out indefinitely with a partially torn left quadriceps.
While expected to return to action on January 26, Griffin was instead ruled out for an estimated four to six weeks due to a right hand injury he sustained on January 23 from hitting a member of the team's equipment staff, who was also his friend, during an argument at a restaurant in Toronto.
The Clippers were sternly critical of Griffin, and indicated that further punitive action would follow.
According to the Toronto Police Service, a police report was not filed.

Griffin missed 45 games in total due to injury and suspension, returning to action for the Clippers on April 3 against the Washington Wizards.
He played 24 minutes as a starter and recorded six points and five rebounds to help the Clippers clinch home-court advantage in the playoffs with a 114–109 win.
He appeared in five of the Clippers' final seven games of the regular season, and managed to appear in the first four first-round playoff games against the Portland Trail Blazers before aggravating the left quad injury in Game 4, which ruled him out for the rest of the postseason.

On November 5, 2016, Griffin scored a season-high 28 points in a 116–92 win over the San Antonio Spurs, helping the Clippers start the season 5–1.
He helped them improve to a league-best 7–1 with 22 points and 13 rebounds against the Portland Trail Blazers on November 9.
With his fifth rebound of the night, Griffin reached 4,000 in 417 career games, the second-fastest player since 1983–84 to reach 8,500 points, 4,000 rebounds and 1,500 assists; Chris Webber did so in 408 games.
On November 11, he helped the Clippers improve to a franchise-best 8–1 with 25 points against the Oklahoma City Thunder.
The following day, in a win over the Minnesota Timberwolves, Griffin joined an exclusive club with 9,000 career points, 4,000 rebounds and 1,500 assists.
He became the fastest player to reach that plateau since Larry Bird.
On December 19, 2016, he was ruled out until some point in January after requiring minor surgery on his right knee.
He returned to action on January 24, 2017, scoring 12 points on 3-of-11 shooting in a 121–110 loss to the Philadelphia 76ers.
On February 6, in just his sixth game since minor knee surgery that had him sidelined for 20 games, Griffin recorded his fifth career triple-double, and first of the season, in three quarters, finishing with 26 points, 11 rebounds and a career-high-tying 11 assists in a 118–109 loss to the Toronto Raptors.
Two days later, he scored a season-high 32 points in a 119–115 win over the New York Knicks.
On February 26, 2017, he set a new season high with 43 points in a 124–121 overtime win over the Charlotte Hornets.
On April 1 against the Los Angeles Lakers, Griffin reached 10,000 career points.
He became the second player in franchise history to reach that mark, joining Randy Smith, who scored 10,467 of his club-record 12,735 points when the team was known as the Buffalo Braves.

On April 22, 2017, Griffin was ruled out for the remainder of the 2017 NBA Playoffs with an injury to the plantar plate of his right big toe suffered during the Clippers' 111–106 win over the Utah Jazz in Game 3 of their Western Conference First Round Playoff series the night before.

On July 19, 2017, Griffin re-signed with the Clippers to a five-year, $173 million contract.
On November 22, 2017, he had 26 points, 10 rebounds and 10 assists in a 116–103 win over the Atlanta Hawks, helping the Clippers snap a nine-game losing streak.
Three days later, he made a 10-foot jumper with 3.2 seconds remaining and had a season-high 33 points to lead the Clippers to a 97–95 win over the Sacramento Kings.
On November 28, 2017, he was ruled out for approximately two months after sustaining an MCL sprain against the Los Angeles Lakers the previous night.
He returned to action earlier than expected on December 29 against the
On November 25, 2015, Griffin recorded season-highs with 40 points and 12 rebounds in a loss to the Utah Jazz, with the Clippers dropping to 7–8 after starting the season 4–0. On December 26, he was ruled out indefinitely with a partially torn left quadriceps. While expected to return to action on January 26, Griffin was instead ruled out for an estimated four to six weeks due to a right hand injury he sustained on January 23 from hitting a member of the team's equipment staff, who was also his friend, during an argument at a restaurant in Toronto. The Clippers were sternly critical of Griffin, and indicated that further punitive action would follow. According to the Toronto Police Service, a police report was not filed.
Griffin missed 45 games in total due to injury and suspension, returning to action for the Clippers on April 3 against the Washington Wizards. He played 24 minutes as a starter and recorded six points and five rebounds to help the Clippers clinch home-court advantage in the playoffs with a 114–109 win. He appeared in five of the Clippers' final seven games of the regular season, and managed to appear in the first four first-round playoff games against the Portland Trail Blazers before aggravating the left quad injury in Game 4, which ruled him out for the rest of the postseason.
On November 5, 2016, Griffin scored a season-high 28 points in a 116–92 win over the San Antonio Spurs, helping the Clippers start the season 5–1. He helped them improve to a league-best 7–1 with 22 points and 13 rebounds against the Portland Trail Blazers on November 9. With his fifth rebound of the night, Griffin reached 4,000 in 417 career games, the second-fastest player since 1983–84 to reach 8,500 points, 4,000 rebounds and 1,500 assists; Chris Webber did so in 408 games. On November 11, he helped the Clippers improve to a franchise-best 8–1 with 25 points against the Oklahoma City Thunder. The following day, in a win over the Minnesota Timberwolves, Griffin joined an exclusive club with 9,000 career points, 4,000 rebounds and 1,500 assists. He became the fastest player to reach that plateau since Larry Bird. On December 19, 2016, he was ruled out until some point in January after requiring minor surgery on his right knee. He returned to action on January 24, 2017, scoring 12 points on 3-of-11 shooting in a 121–110 loss to the Philadelphia 76ers. On February 6, in just his sixth game since minor knee surgery that had him sidelined for 20 games, Griffin recorded his fifth career triple-double, and first of the season, in three quarters, finishing with 26 points, 11 rebounds and a career-high-tying 11 assists in a 118–109 loss to the Toronto Raptors. Two days later, he scored a season-high 32 points in a 119–115 win over the New York Knicks. On February 26, 2017, he set a new season high with 43 points in a 124–121 overtime win over the Charlotte Hornets. On April 1 against the Los Angeles Lakers, Griffin reached 10,000 career points. He became the second player in franchise history to reach that mark, joining Randy Smith, who scored 10,467 of his club-record 12,735 points when the team was known as the Buffalo Braves.
On April 22, 2017, Griffin was ruled out for the remainder of the 2017 NBA Playoffs with an injury to the plantar plate of his right big toe suffered during the Clippers' 111–106 win over the Utah Jazz in Game 3 of their Western Conference First Round Playoff series the night before.
On July 19, 2017, Griffin re-signed with the Clippers to a five-year, $173 million contract. On November 22, 2017, he had 26 points, 10 rebounds and 10 assists in a 116–103 win over the Atlanta Hawks, helping the Clippers snap a nine-game losing streak. Three days later, he made a 10-foot jumper with 3.2 seconds remaining and had a season-high 33 points to lead the Clippers to a 97–95 win over the Sacramento Kings. On November 28, 2017, he was ruled out for approximately two months after sustaining an MCL sprain against the Los Angeles Lakers the previous night. He returned to action earlier than expected on December 29 against the
Blake Griffin