Rudnytska began working as a journalist on the biweekly editorial Наша Мета (Our goal) in 1918.
The following year, she married Pavlo Lysiak a lawyer politician who had also studied at Lviv and was living in Austria.
By the end of the year, the couple had their only child, Ivan and their home quickly became a gathering place for leaders of the Ukrainian intellectual community living in Vienna.
Back home in Galicia the Polish–Ukrainian War had resulted in a territorial transfer to the Polish state and adoption of policies to suppress minority populations.
Though Rudnytska supported the Ukrainian national movement, she felt that women had been assigned inferior roles.
She began to focus her attention on organizing women and involving them in raising the civic consciousness of a Ukrainian Nation.
Returning to Lviv in 1920, Rudnytska and her husband soon separated.
Her son, raised among her family, subsequently adopted her surname as his own.

Rudnytska became one of the leading activists of the Ukrainian Women's Union (Ukrainian: Союз українок), which she helped found in 1920 and along with other members of the leadership, including Olena Fedak Sheparovych, Iryna Sichynska, Olga Tsipanovska and others, organized women's journals, conferences, and cooperatives.
Around the same time, in 1921 she began working in the Teacher's Seminary and later worked at the Higher Pedagogical Institute, both in Lviv, but in 1928, she stopped teaching and turned her focus entirely to social and political issues.
Having joined the Ukrainian National Democratic Alliance, Rudnytska was elected to serve in the Polish Sejm in 1928 as a party representative, serving through 1935.
That same year, she was elected as president of the Woman's Union and served in that capacity until 1939.
Until 1939, she continued her journalistic endeavors as well publishing with several feminist journals like, Woman (Ukrainian: жінка), Woman-citizen (Ukrainian: Громадянина), Ukrainian Woman (Ukrainian: Українка) and edited the woman's page of the Ukrainian daily newspaper Action (Ukrainian: газета дію).

In Parliament, Rudnytska was a staunch advocate for Ukraine and criticized the Polish authorities for suppressing Ukrainian culture including their schools and religious institutions.
Serving on committees for education and foreign affairs, she gave many speeches and was known as a charismatic orator.
In 1931, she was one of three delegates from Ukraine to present the case against the Polish officials to the League of Nations, calling the suppression a "pacification campaign" to silence the Ukrainian minority population.
She was also invited to speak on the issue at the British House Of Commons.
During the 1932-1933 famine she was elected vice chair of the Public Rescue Committee, and organized meetings including politicians, scientists, and educators to address the issue and provide famine relief.
Through her international ties with women's organizations, Rudnytska was selected to seek international aid support and bring the situation to the attention of the League of Nations.

On 29 September 1933, in Geneva 14 countries met and Rudnytska along with the other members of the Ukrainian delegation presented their findings about the famine and the need for international assistance.
After several hours, the League decision was that the famine was an internal problem of the USSR, which was not a member of the League and therefore no help would be forthcoming.
The delegation then turned toward the International Committee of the Red Cross (ICRC) with a plea for help.
ICRC officials contacted Soviet officials to gain approval for the Red Cross to organize international aid for Ukraine, but the head of the Soviet Red Crescent Society, Avel Yenukidze denied that there was any famine in Ukraine.
Rudnytska spoke at another international conference held in Vienna in December 1933 urging that the international community pressure the Stalinist regime to admit there was a crisis and allow aid.
Denial continued and information about the nature and scope of the famine was suppressed.
In
Rudnytska began working as a journalist on the biweekly editorial Наша Мета (Our goal) in 1918. The following year, she married Pavlo Lysiak a lawyer politician who had also studied at Lviv and was living in Austria. By the end of the year, the couple had their only child, Ivan and their home quickly became a gathering place for leaders of the Ukrainian intellectual community living in Vienna. Back home in Galicia the Polish–Ukrainian War had resulted in a territorial transfer to the Polish state and adoption of policies to suppress minority populations. Though Rudnytska supported the Ukrainian national movement, she felt that women had been assigned inferior roles. She began to focus her attention on organizing women and involving them in raising the civic consciousness of a Ukrainian Nation. Returning to Lviv in 1920, Rudnytska and her husband soon separated. Her son, raised among her family, subsequently adopted her surname as his own.
Rudnytska became one of the leading activists of the Ukrainian Women's Union (Ukrainian: Союз українок), which she helped found in 1920 and along with other members of the leadership, including Olena Fedak Sheparovych, Iryna Sichynska, Olga Tsipanovska and others, organized women's journals, conferences, and cooperatives. Around the same time, in 1921 she began working in the Teacher's Seminary and later worked at the Higher Pedagogical Institute, both in Lviv, but in 1928, she stopped teaching and turned her focus entirely to social and political issues. Having joined the Ukrainian National Democratic Alliance, Rudnytska was elected to serve in the Polish Sejm in 1928 as a party representative, serving through 1935. That same year, she was elected as president of the Woman's Union and served in that capacity until 1939. Until 1939, she continued her journalistic endeavors as well publishing with several feminist journals like, Woman (Ukrainian: жінка), Woman-citizen (Ukrainian: Громадянина), Ukrainian Woman (Ukrainian: Українка) and edited the woman's page of the Ukrainian daily newspaper Action (Ukrainian: газета дію).
In Parliament, Rudnytska was a staunch advocate for Ukraine and criticized the Polish authorities for suppressing Ukrainian culture including their schools and religious institutions. Serving on committees for education and foreign affairs, she gave many speeches and was known as a charismatic orator. In 1931, she was one of three delegates from Ukraine to present the case against the Polish officials to the League of Nations, calling the suppression a "pacification campaign" to silence the Ukrainian minority population. She was also invited to speak on the issue at the British House Of Commons. During the 1932-1933 famine she was elected vice chair of the Public Rescue Committee, and organized meetings including politicians, scientists, and educators to address the issue and provide famine relief. Through her international ties with women's organizations, Rudnytska was selected to seek international aid support and bring the situation to the attention of the League of Nations.
On 29 September 1933, in Geneva 14 countries met and Rudnytska along with the other members of the Ukrainian delegation presented their findings about the famine and the need for international assistance. After several hours, the League decision was that the famine was an internal problem of the USSR, which was not a member of the League and therefore no help would be forthcoming. The delegation then turned toward the International Committee of the Red Cross (ICRC) with a plea for help. ICRC officials contacted Soviet officials to gain approval for the Red Cross to organize international aid for Ukraine, but the head of the Soviet Red Crescent Society, Avel Yenukidze denied that there was any famine in Ukraine. Rudnytska spoke at another international conference held in Vienna in December 1933 urging that the international community pressure the Stalinist regime to admit there was a crisis and allow aid. Denial continued and information about the nature and scope of the famine was suppressed. In 
Milena Rudnytska