The Upstate is served by two major interstate highways, I-85 and I-26.
 Other major interstate spurs include I-185, I-385, and I-585.
 The major airport in the region is Greenville-Spartanburg International Airport, located nearly halfway between Greenville and Spartanburg in suburban Greer.
 Greenville, Spartanburg, Anderson, Clemson, Pickens, Union, and Gaffney each have smaller airfields.
AMTRAK service along the Crescent Line stops in Spartanburg, Greenville, and Clemson.
The Upstate is served by two major interstate highways, I-85 and I-26.  Other major interstate spurs include I-185, I-385, and I-585.  The major airport in the region is Greenville-Spartanburg International Airport, located nearly halfway between Greenville and Spartanburg in suburban Greer.  Greenville, Spartanburg, Anderson, Clemson, Pickens, Union, and Gaffney each have smaller airfields. AMTRAK service along the Crescent Line stops in Spartanburg, Greenville, and Clemson.
Upstate South Carolina