On 2 April 2007, Blanco ventured on to Major League Soccer in the United States and signed with Chicago Fire.
He was welcomed by 5,000 fans at Toyota Park as he conducted interviews with the media, signed autographs and greeted with fans.

He was later voted as a finalist for both the MVP and Newcomer of the Year awards in 2007.
Blanco was the 2007 Goal of the Year winner, for his goal against Real Salt Lake.

Blanco was the second-highest paid player in Major League Soccer, after Los Angeles Galaxy midfielder David Beckham, earning $2.7 million a year.
Once again, he was a finalist for the MVP of the year award.

On 24 July 2008, in the All-Stars Game against West Ham United, Blanco won the MVP award with one assist and one goal, a game in which he only played 46 minutes.
The MLS All-stars won 3–2.
On 2 April 2007, Blanco ventured on to Major League Soccer in the United States and signed with Chicago Fire. He was welcomed by 5,000 fans at Toyota Park as he conducted interviews with the media, signed autographs and greeted with fans.
He was later voted as a finalist for both the MVP and Newcomer of the Year awards in 2007. Blanco was the 2007 Goal of the Year winner, for his goal against Real Salt Lake.
Blanco was the second-highest paid player in Major League Soccer, after Los Angeles Galaxy midfielder David Beckham, earning $2.7 million a year. Once again, he was a finalist for the MVP of the year award.
On 24 July 2008, in the All-Stars Game against West Ham United, Blanco won the MVP award with one assist and one goal, a game in which he only played 46 minutes. The MLS All-stars won 3–2.
Cuauhtémoc Blanco