Wynn was married to former stage actress Eve Lynn Abbott (1914–2004) until their divorce in 1947, whereupon Abbott married actor Van Johnson, one of the couple's closest friends.
Abbott contended her marriage to Wynn was a happy one but that her divorce and remarriage was engineered by MGM studio-boss Louis B. Mayer, who refused to renew Wynn's contract unless Abbott divorced him and married Johnson, who was the subject of rumors that he was homosexual.
One son, actor and writer Ned Wynn (born Edmond Keenan Wynn), wrote the autobiographical memoir We Will Always Live In Beverly Hills.
His other son, Tracy Keenan Wynn, is a screenwriter whose credits include The Longest Yard and The Autobiography of Miss Jane Pittman (both 1974).

His daughter Hilda was married to Paul Williams.
He was an uncle by marriage to the Hudson Brothers.
In his later years, Wynn undertook a number of philanthropic endeavors and supported several charity groups.
He was a long-standing active member of the Westwood Sertoma service club, in West Los Angeles.
During his last years, Wynn suffered from pancreatic cancer, which caused his death on October 14, 1986.
His ashes are interred in Glendale's Forest Lawn Memorial Park in The Great Mausoleum, Daffodil Corridor, Columbarium of the Dawn, in a niche alongside his father, Ed Wynn, his daughter, Emily (February 13, 1960 – November 27, 1980) who died from lupus, and his aunt, Blanche Leopold (May 18, 1880 – December 26, 1973).
His granddaughter is actress Jessica Keenan Wynn.
Wynn was married to former stage actress Eve Lynn Abbott (1914–2004) until their divorce in 1947, whereupon Abbott married actor Van Johnson, one of the couple's closest friends. Abbott contended her marriage to Wynn was a happy one but that her divorce and remarriage was engineered by MGM studio-boss Louis B. Mayer, who refused to renew Wynn's contract unless Abbott divorced him and married Johnson, who was the subject of rumors that he was homosexual. One son, actor and writer Ned Wynn (born Edmond Keenan Wynn), wrote the autobiographical memoir We Will Always Live In Beverly Hills. His other son, Tracy Keenan Wynn, is a screenwriter whose credits include The Longest Yard and The Autobiography of Miss Jane Pittman (both 1974).
His daughter Hilda was married to Paul Williams. He was an uncle by marriage to the Hudson Brothers. In his later years, Wynn undertook a number of philanthropic endeavors and supported several charity groups. He was a long-standing active member of the Westwood Sertoma service club, in West Los Angeles. During his last years, Wynn suffered from pancreatic cancer, which caused his death on October 14, 1986. His ashes are interred in Glendale's Forest Lawn Memorial Park in The Great Mausoleum, Daffodil Corridor, Columbarium of the Dawn, in a niche alongside his father, Ed Wynn, his daughter, Emily (February 13, 1960 – November 27, 1980) who died from lupus, and his aunt, Blanche Leopold (May 18, 1880 – December 26, 1973). His granddaughter is actress Jessica Keenan Wynn.
Keenan Wynn