MPP+ can be readily synthesized in the laboratory, with Zhang and colleagues publishing a representative synthesis in 2017.
The synthesis involves reacting 4-phenylpyridine with methyl iodide in acetonitrile solvent at reflux for 24 hours.
An inert atmosphere is used to ensure a quantitative yield.
The product is formed as the iodide salt, and the reaction proceeds via an SN2 pathway.
The industrial synthesis of MPP+ for sale as the herbicide cyperquat used methyl chloride as the source of the methyl group.
MPP+ can be readily synthesized in the laboratory, with Zhang and colleagues publishing a representative synthesis in 2017. The synthesis involves reacting 4-phenylpyridine with methyl iodide in acetonitrile solvent at reflux for 24 hours. An inert atmosphere is used to ensure a quantitative yield. The product is formed as the iodide salt, and the reaction proceeds via an SN2 pathway. The industrial synthesis of MPP+ for sale as the herbicide cyperquat used methyl chloride as the source of the methyl group.
MPP+