During the ovarian cycle, GnRH secretion along with that of luteinizing hormone (LH) is highly regulated.
This regulation occurs by a negative feedback system.
Neurokinin B along with its sister peptides of the KNDy subpopulation regulate this feedback.
The NK3R receptor group when activated with a synthetic agonist of NKB, senktide, has been shown to stimulate the secretion of luteinizing hormone.
 In addition, studies have shown that NKB plays a larger role in females than in males.
It has been found that in brain of females, the arcuate nucleus contains twice as many connections to NKB neurons than males.
During the ovarian cycle, GnRH secretion along with that of luteinizing hormone (LH) is highly regulated. This regulation occurs by a negative feedback system. Neurokinin B along with its sister peptides of the KNDy subpopulation regulate this feedback. The NK3R receptor group when activated with a synthetic agonist of NKB, senktide, has been shown to stimulate the secretion of luteinizing hormone.  In addition, studies have shown that NKB plays a larger role in females than in males. It has been found that in brain of females, the arcuate nucleus contains twice as many connections to NKB neurons than males.
Neurokinin B