After passing LPGA Qualifying School in December 2008, Wie declared that she still planned to play in tournaments against men.
However, for the second consecutive year, she did not receive a sponsor exemption to play in the Sony Open in Hawaii where she had played four years in a row from 2004 through 2007.
Her first tournament as an LPGA member was the season-opening SBS Open at Turtle Bay where she shot 66, 70 to move into a tie with Angela Stanford going into the final round of the tournament.
Wie held a three-stroke lead with eight holes remaining, but ended up losing to Stanford by three strokes.

It was reported in early March, 2009, that Wie had left the William Morris Agency, the Hollywood talent agency that had represented her since she turned pro in 2005, and would be signing with sports agency IMG.

At the second major of the year, the LPGA Championship, she finished tied for 23rd, her best finish in a major since 2006.
During this tournament she also scored her first recorded hole-in-one as a professional.
However, the day after her final round of the LPGA Championship, she failed to qualify for the U.S. Women's Open due to a mediocre performance at a sectional qualifying tournament.

In August, at Rich Harvest Farms golf course in Sugar Grove, Illinois, Wie was a captain's pick for the United States team in Solheim Cup competition, where she led the American squad to victory with a 3-0-1 performance, the best record on the American team.

On November 15, 2009, Wie won her first professional individual tournament, the Lorena Ochoa Invitational in Guadalajara, Mexico, a limited field event on the LPGA Tour, posting a score of thirteen under par 275 for a two-stroke margin over fellow American Paula Creamer, and beating Jiyai Shin, Cristie Kerr and Morgan Pressel by two strokes.
 She then finished second in the Ladies European Tour season-ending Dubai Ladies Masters tournament on December 9–12, 2009, shooting a 15-under-par 273, which put her three shots behind winner In-Kyung Kim.

On August 29, 2010, she posted a three-shot win over a full field at the CN Canadian Women's Open, held at St. Charles Country Club in Winnipeg, Manitoba, for her second career professional victory.
 In her next LPGA event two weeks later, she finished second in the 54-hole P&G NW Arkansas Championship shooting 201 (−12) and losing to Yani Tseng by one stroke after giving up an overnight three-stroke lead.

On April 19, 2014, Wie won her third LPGA Tour event – and her first in the United States – the LPGA Lotte Championship.
She was four strokes behind Angela Stanford after 54 holes but shot a 67 to Stanford's 73 to win by two strokes.

On June 22, 2014, Wie won her fourth LPGA Tour event and first major championship, the U.S. Women's Open.
She was tied for the lead with Amy Yang after 54 holes at two-under-par.
She double-bogeyed the 16th hole to fall within one shot of Stacy Lewis, but birdied the next hole and parred the last hole for a final round par-70 to win by two strokes over Lewis.
The win, coupled with her second-place finish in the 2014 Kraft Nabisco Championship, resulted in her winning the inaugural Rolex Annika Major Award.
In 2014, she was also named one of ESPNW's Impact 25.

Wie will contribute to CBS Sports’ multimedia golf coverage, including the Masters starting in 2020.
After passing LPGA Qualifying School in December 2008, Wie declared that she still planned to play in tournaments against men. However, for the second consecutive year, she did not receive a sponsor exemption to play in the Sony Open in Hawaii where she had played four years in a row from 2004 through 2007. Her first tournament as an LPGA member was the season-opening SBS Open at Turtle Bay where she shot 66, 70 to move into a tie with Angela Stanford going into the final round of the tournament. Wie held a three-stroke lead with eight holes remaining, but ended up losing to Stanford by three strokes.
It was reported in early March, 2009, that Wie had left the William Morris Agency, the Hollywood talent agency that had represented her since she turned pro in 2005, and would be signing with sports agency IMG.
At the second major of the year, the LPGA Championship, she finished tied for 23rd, her best finish in a major since 2006. During this tournament she also scored her first recorded hole-in-one as a professional. However, the day after her final round of the LPGA Championship, she failed to qualify for the U.S. Women's Open due to a mediocre performance at a sectional qualifying tournament.
In August, at Rich Harvest Farms golf course in Sugar Grove, Illinois, Wie was a captain's pick for the United States team in Solheim Cup competition, where she led the American squad to victory with a 3-0-1 performance, the best record on the American team.
On November 15, 2009, Wie won her first professional individual tournament, the Lorena Ochoa Invitational in Guadalajara, Mexico, a limited field event on the LPGA Tour, posting a score of thirteen under par 275 for a two-stroke margin over fellow American Paula Creamer, and beating Jiyai Shin, Cristie Kerr and Morgan Pressel by two strokes.  She then finished second in the Ladies European Tour season-ending Dubai Ladies Masters tournament on December 9–12, 2009, shooting a 15-under-par 273, which put her three shots behind winner In-Kyung Kim.
On August 29, 2010, she posted a three-shot win over a full field at the CN Canadian Women's Open, held at St. Charles Country Club in Winnipeg, Manitoba, for her second career professional victory.  In her next LPGA event two weeks later, she finished second in the 54-hole P&G NW Arkansas Championship shooting 201 (−12) and losing to Yani Tseng by one stroke after giving up an overnight three-stroke lead.
On April 19, 2014, Wie won her third LPGA Tour event – and her first in the United States – the LPGA Lotte Championship. She was four strokes behind Angela Stanford after 54 holes but shot a 67 to Stanford's 73 to win by two strokes.
On June 22, 2014, Wie won her fourth LPGA Tour event and first major championship, the U.S. Women's Open. She was tied for the lead with Amy Yang after 54 holes at two-under-par. She double-bogeyed the 16th hole to fall within one shot of Stacy Lewis, but birdied the next hole and parred the last hole for a final round par-70 to win by two strokes over Lewis. The win, coupled with her second-place finish in the 2014 Kraft Nabisco Championship, resulted in her winning the inaugural Rolex Annika Major Award. In 2014, she was also named one of ESPNW's Impact 25.
Wie will contribute to CBS Sports’ multimedia golf coverage, including the Masters starting in 2020.
Michelle Wie