In Nauvoo, the Twelve Apostles assigned Woodruff to assist with the church's temporal matters in Nauvoo.
He became co-manager of Times and Seasons in February 1842.
Woodruff supervised the physical printing of the paper, and he and John Taylor also published a general interest newspaper called Nauvoo Neighbor starting in May 1843.
He bought and sold real estate, helped clerk in a provision store, and farmed.
He became a member of the Nauvoo city council and served as chaplain for the Nauvoo Legion, a local militia.
He also helped to organize the Nauvoo Masonic Lodge and the Nauvoo Agricultural and Manufacturing Society.
As a member of the Twelve Apostles, he was also a member of the Council of Fifty.
He took detailed notes on the King Follett discourse.
He joined the other Twelve Apostles in a trip to the east coast to raise funds for a temple and hotel under construction in Nauvoo, setting out in July 1843 and returning in November 1843.
Woodruff and his wife Phebe received their second anointing in Nauvoo in 1844, making them members of the Anointed Quorum.
In May 1844, Woodruff left on another trip to preach and promote Joseph Smith's presidential campaign.
News of Joseph Smith's death reached Woodruff on July 9, and fellow apostles returned to Nauvoo in August.

The Twelve Apostles called Woodruff and Phebe to serve in England together.
They left Nauvoo in August 1844, leaving their eldest child with a family in Nauvoo.
The left their 3-year-old with Phebe's parents in Maine, bringing their one-year-old with them to England.
Woodruff worked to square the mission account books and visited wards and branches throughout the United Kingdom, establishing the authority of the Twelve Apostles after Joseph Smith's death.
Members in England tried to form a joint stock company trading with Nauvoo in cotton, wool, and iron.
The company failed because of unrest in Nauvoo and problems in management.
After hearing that members had been driven out of Nauvoo, the Woodruffs left England in January 1846.
Woodruff picked up their daughter and brought some of his relatives with him to Nauvoo, but Woodruff's relatives decided to join James Strang's followers rather than move west.

Before leaving Nauvoo, Woodruff and Orson Hyde dedicated the temple on April 30, 1846.
Woodruff oversaw forty families, and they stayed at Winter Quarters.
Many people got sick in Winter Quarters, and Woodruff's 16-month-old son Joseph died of a respiratory infection on November 12, 1846.
Phebe's friend from England, Jane Benbow, also died, and Phebe went into labor 6 weeks early, giving birth to a son who died two days after birth.
Woodruff joined an advance company that left in April 1847 to find a place to settle, leaving his family in Winter Quarters.
Woodruff suffered various ailments, as did most of the other migrants.
They arrived in Salt Lake Valley on July 24 and immediately planted crops.
Woodruff learned to fly fish in England, and his 1847 journal account of his fishing in the East Fork River is the earliest known account of fly fishing west of the Mississippi River.
Woodruff returned to Winter Quarters that October 31; Phebe was there and had given birth three days earlier to a daughter named Shuah.
The Twelve assigned Woodruff to preside over the Eastern States Mission, centered in Boston.
Phebe was specially blessed to teach and be a mother in Israel, and they left Winter Quarters in June 1848.
Shuah died, probably of dysentery, on July 22 during the journey east.
Phebe went with the children to visit her father in Maine while Woodruff organized church work on the East coast.
He organized branches, preached, and resolved conflicts.
in 1849, Phebe's father and a sister joined the church in 1849.
Woodruff led 200 members in travelling west starting in February 1850.
They arrived in Nebraska in May 1850, where the price of oxen and their drivers was steep.
The trail was heavily grazed by other travellers, leaving little food for their oxen, and half died.
Woodruff sent word to Brigham Young that his party needed oxen, and a party from Salt Lake City
In Nauvoo, the Twelve Apostles assigned Woodruff to assist with the church's temporal matters in Nauvoo. He became co-manager of Times and Seasons in February 1842. Woodruff supervised the physical printing of the paper, and he and John Taylor also published a general interest newspaper called Nauvoo Neighbor starting in May 1843. He bought and sold real estate, helped clerk in a provision store, and farmed. He became a member of the Nauvoo city council and served as chaplain for the Nauvoo Legion, a local militia. He also helped to organize the Nauvoo Masonic Lodge and the Nauvoo Agricultural and Manufacturing Society. As a member of the Twelve Apostles, he was also a member of the Council of Fifty. He took detailed notes on the King Follett discourse. He joined the other Twelve Apostles in a trip to the east coast to raise funds for a temple and hotel under construction in Nauvoo, setting out in July 1843 and returning in November 1843. Woodruff and his wife Phebe received their second anointing in Nauvoo in 1844, making them members of the Anointed Quorum. In May 1844, Woodruff left on another trip to preach and promote Joseph Smith's presidential campaign. News of Joseph Smith's death reached Woodruff on July 9, and fellow apostles returned to Nauvoo in August.
The Twelve Apostles called Woodruff and Phebe to serve in England together. They left Nauvoo in August 1844, leaving their eldest child with a family in Nauvoo. The left their 3-year-old with Phebe's parents in Maine, bringing their one-year-old with them to England. Woodruff worked to square the mission account books and visited wards and branches throughout the United Kingdom, establishing the authority of the Twelve Apostles after Joseph Smith's death. Members in England tried to form a joint stock company trading with Nauvoo in cotton, wool, and iron. The company failed because of unrest in Nauvoo and problems in management. After hearing that members had been driven out of Nauvoo, the Woodruffs left England in January 1846. Woodruff picked up their daughter and brought some of his relatives with him to Nauvoo, but Woodruff's relatives decided to join James Strang's followers rather than move west.
Before leaving Nauvoo, Woodruff and Orson Hyde dedicated the temple on April 30, 1846. Woodruff oversaw forty families, and they stayed at Winter Quarters. Many people got sick in Winter Quarters, and Woodruff's 16-month-old son Joseph died of a respiratory infection on November 12, 1846. Phebe's friend from England, Jane Benbow, also died, and Phebe went into labor 6 weeks early, giving birth to a son who died two days after birth. Woodruff joined an advance company that left in April 1847 to find a place to settle, leaving his family in Winter Quarters. Woodruff suffered various ailments, as did most of the other migrants. They arrived in Salt Lake Valley on July 24 and immediately planted crops. Woodruff learned to fly fish in England, and his 1847 journal account of his fishing in the East Fork River is the earliest known account of fly fishing west of the Mississippi River. Woodruff returned to Winter Quarters that October 31; Phebe was there and had given birth three days earlier to a daughter named Shuah. The Twelve assigned Woodruff to preside over the Eastern States Mission, centered in Boston. Phebe was specially blessed to teach and be a mother in Israel, and they left Winter Quarters in June 1848. Shuah died, probably of dysentery, on July 22 during the journey east. Phebe went with the children to visit her father in Maine while Woodruff organized church work on the East coast. He organized branches, preached, and resolved conflicts. in 1849, Phebe's father and a sister joined the church in 1849. Woodruff led 200 members in travelling west starting in February 1850. They arrived in Nebraska in May 1850, where the price of oxen and their drivers was steep. The trail was heavily grazed by other travellers, leaving little food for their oxen, and half died. Woodruff sent word to Brigham Young that his party needed oxen, and a party from Salt Lake City 
Wilford Woodruff