After a year's preparation, on 15 June 1833, just 21, he sailed for China to take charge of the printing press of the American Board of Commissioners for Foreign Missions at Guangdong, China.
He arrived at Whampoa, Canton, aboard the Morrison on 25 October 1833.
 With the death of the pioneering missionary Robert Morrison the next year, he and Elijah Bridgman, who had arrived only three years ahead of Williams, were the only missionaries in the whole of China.
 He assisted Bridgman in the latter's Chinese Chrestomathy in the Canton Dialect, published in 1842, and Walter Medhurst in completing his English-Chinese Dictionary of 1848, two early works of Chinese lexicography.

In 1837 he sailed on the Morrison to Japan.
Officially this trip was to return some stranded Japanese sailors, but it was also an unsuccessful attempt to open Japan to American trade.

On November 20, 1845 Williams married Sarah Walworth.
From 1848 to 1851 Williams was the editor of The Chinese Repository, a leading Western journal published in China.
In 1853 he was attached to Commodore Matthew Calbraith Perry's expedition to Japan as an official interpreter.

In 1855, Williams was appointed Secretary of the United States Legation to China.
During his stay in China, he wrote A Tonic Dictionary Of The Chinese Language In The Canton Dialect (英華分韻撮要) in 1856.
After years of opposition from the Chinese government, Williams was instrumental in the negotiation of the Treaty of Tientsin, which provided for the toleration of both Chinese and foreign Christians.

In 1860, he was appointed chargé d'affaires for the United States in Beijing.
He resigned his position on October 25, 1876, 43 years to the day that he first landed at Guangzhou in 1833.
Around 1875, he completed a translation of the Book of Genesis and the Gospel of Matthew into Japanese, but the manuscripts were lost in a fire before they could be published.

He returned to the United States in 1877 and became the first Professor of Chinese language and literature in the United States at Yale University.
Williams was nominated as president of the American Bible Society on February 3, 1881.
He died on February 16, 1884.
After a year's preparation, on 15 June 1833, just 21, he sailed for China to take charge of the printing press of the American Board of Commissioners for Foreign Missions at Guangdong, China. He arrived at Whampoa, Canton, aboard the Morrison on 25 October 1833.  With the death of the pioneering missionary Robert Morrison the next year, he and Elijah Bridgman, who had arrived only three years ahead of Williams, were the only missionaries in the whole of China.  He assisted Bridgman in the latter's Chinese Chrestomathy in the Canton Dialect, published in 1842, and Walter Medhurst in completing his English-Chinese Dictionary of 1848, two early works of Chinese lexicography.
In 1837 he sailed on the Morrison to Japan. Officially this trip was to return some stranded Japanese sailors, but it was also an unsuccessful attempt to open Japan to American trade.
On November 20, 1845 Williams married Sarah Walworth. From 1848 to 1851 Williams was the editor of The Chinese Repository, a leading Western journal published in China. In 1853 he was attached to Commodore Matthew Calbraith Perry's expedition to Japan as an official interpreter.
In 1855, Williams was appointed Secretary of the United States Legation to China. During his stay in China, he wrote A Tonic Dictionary Of The Chinese Language In The Canton Dialect (英華分韻撮要) in 1856. After years of opposition from the Chinese government, Williams was instrumental in the negotiation of the Treaty of Tientsin, which provided for the toleration of both Chinese and foreign Christians.
In 1860, he was appointed chargé d'affaires for the United States in Beijing. He resigned his position on October 25, 1876, 43 years to the day that he first landed at Guangzhou in 1833. Around 1875, he completed a translation of the Book of Genesis and the Gospel of Matthew into Japanese, but the manuscripts were lost in a fire before they could be published.
He returned to the United States in 1877 and became the first Professor of Chinese language and literature in the United States at Yale University. Williams was nominated as president of the American Bible Society on February 3, 1881. He died on February 16, 1884.
Samuel Wells Williams