Pico de Orizaba is located at 19°1′48″N 97°16′12″W, about 110 kilometres (68 mi) west of the Gulf of Mexico and 200 kilometres (120 mi) east of Mexico City, on the border between the states of Veracruz and Puebla.
The volcano is approximately 480 kilometres (300 mi) south of the Tropic of Cancer.
Orizaba anchors the south-eastern end of the Trans-Mexican Volcanic Belt, a volcanic chain that runs from west to east across Central Mexico.
A companion peak lying about six km to the southwest of Pico de Orizaba is the Sierra Negra, at 4,640 metres (15,223 ft).
This subsidiary peak is significantly lower than its massive neighbour, but the road to the observatory on its summit is the highest road in North America.

Pico de Orizaba, as part of the Sierra Madre Oriental, forms a barrier between the coastal plains of the Gulf of Mexico and the Mexican Plateau.
The volcano blocks the moisture from the Gulf of Mexico from saturating central Mexico and influences the climates of both areas.
Both the state of Veracruz and Puebla depend on Pico de Orizaba for supplying fresh water.
The largest river originating on the volcano is the Jamapa River.
Pico de Orizaba is located at 19°1′48″N 97°16′12″W, about 110 kilometres (68 mi) west of the Gulf of Mexico and 200 kilometres (120 mi) east of Mexico City, on the border between the states of Veracruz and Puebla. The volcano is approximately 480 kilometres (300 mi) south of the Tropic of Cancer. Orizaba anchors the south-eastern end of the Trans-Mexican Volcanic Belt, a volcanic chain that runs from west to east across Central Mexico. A companion peak lying about six km to the southwest of Pico de Orizaba is the Sierra Negra, at 4,640 metres (15,223 ft). This subsidiary peak is significantly lower than its massive neighbour, but the road to the observatory on its summit is the highest road in North America.
Pico de Orizaba, as part of the Sierra Madre Oriental, forms a barrier between the coastal plains of the Gulf of Mexico and the Mexican Plateau. The volcano blocks the moisture from the Gulf of Mexico from saturating central Mexico and influences the climates of both areas. Both the state of Veracruz and Puebla depend on Pico de Orizaba for supplying fresh water. The largest river originating on the volcano is the Jamapa River.
Pico de Orizaba