His architectural designs continued with the "Human-City" architecture model for MW Energie AG in Mannheim, Germany (2000) and subsequently with an experimental house design for Hanse-Haus, the German prefabricators.
 
He designed new optical frames presented at shows in Milan, Paris and Las Vegas and in 2001 designed a new microscope and photo camera (for Seagull) at the Colani Shanghai office.
He held more than thirty exhibitions in shopping malls (ECE-group) throughout Germany.
He also opened of a world-leading museum of design, Pinakothek der Moderne, in Munich, Germany which featured several Colani designs (2002).

In the realm of packaging design, he created a new bottle design for the leading Swiss mineral-water company Valser (acquired by Coca-Cola in 2002) and created porcelain giftware creations (Cappuccino, Espresso mugs).

He undertook a "Life on Board" project for Volvo cars and created a futuristic car design called the Speedster shark.

He continued his large Supertruck designs with extreme streamlining, this time for Spitzer-Silo; the result was presented at the IAA in Hanover, Germany (2004).

A notable uniform commission was the 2003 re-design of police uniforms for the Hamburg Police department, which was later adopted throughout the whole of Germany.

In the years 2004 to 2007, a retrospective exhibition of Colani's work, called COLANI – Das Lebenswerk, took place in the "Nancy hall" of the congress center of Karlsruhe.
The exhibition was not continued as funding of the hall's renovation was not achieved.

In 2007, the Design Museum in London showed his work in the exhibit Translating Nature.

In avionics, he designed the tt-62-plane for hp-aircraft.de.
He also completed a design study for a 1,000 seat passenger airplane (2005).

He completed a series of 140 sculptures of athletes for the Olympic Games in Beijing.
He also participated in the "Germany in Japan 2005-6" event in the form of the "Colani Back in Japan" exhibition in the Museum for Art and Design attached to the Kyoto Institute of Technology.
He also carried out a study for a robot shaped like a baby.

In 2013 the first Model (AC22) of the AGOS Luxury Computer Series, Opus Magnum, was presented at the Nowa Zukunftsmesse in Marburg, Germany.
His architectural designs continued with the "Human-City" architecture model for MW Energie AG in Mannheim, Germany (2000) and subsequently with an experimental house design for Hanse-Haus, the German prefabricators.  
He designed new optical frames presented at shows in Milan, Paris and Las Vegas and in 2001 designed a new microscope and photo camera (for Seagull) at the Colani Shanghai office. He held more than thirty exhibitions in shopping malls (ECE-group) throughout Germany. He also opened of a world-leading museum of design, Pinakothek der Moderne, in Munich, Germany which featured several Colani designs (2002).
In the realm of packaging design, he created a new bottle design for the leading Swiss mineral-water company Valser (acquired by Coca-Cola in 2002) and created porcelain giftware creations (Cappuccino, Espresso mugs). 
He undertook a "Life on Board" project for Volvo cars and created a futuristic car design called the Speedster shark.
He continued his large Supertruck designs with extreme streamlining, this time for Spitzer-Silo; the result was presented at the IAA in Hanover, Germany (2004). 
A notable uniform commission was the 2003 re-design of police uniforms for the Hamburg Police department, which was later adopted throughout the whole of Germany.
In the years 2004 to 2007, a retrospective exhibition of Colani's work, called COLANI – Das Lebenswerk, took place in the "Nancy hall" of the congress center of Karlsruhe. The exhibition was not continued as funding of the hall's renovation was not achieved.
In 2007, the Design Museum in London showed his work in the exhibit Translating Nature.
In avionics, he designed the tt-62-plane for hp-aircraft.de. He also completed a design study for a 1,000 seat passenger airplane (2005).
He completed a series of 140 sculptures of athletes for the Olympic Games in Beijing. He also participated in the "Germany in Japan 2005-6" event in the form of the "Colani Back in Japan" exhibition in the Museum for Art and Design attached to the Kyoto Institute of Technology. He also carried out a study for a robot shaped like a baby.
In 2013 the first Model (AC22) of the AGOS Luxury Computer Series, Opus Magnum, was presented at the Nowa Zukunftsmesse in Marburg, Germany.
Luigi Colani