On April 10, 2012, Kreider signed a three-year, entry-level contract with the Rangers.
He joined New York the following day for practice, and was declared eligible to participate in the 2012 Stanley Cup playoffs.
He made his NHL debut a few days later in a Game 3 of the Eastern Conference Quarter-finals on April 16, 2012.
He scored his first career NHL goal in Game 6 of that series on April 23 with an assist from former World Junior Championship teammate Derek Stepan, which proved to be the game-winner.

Kreider's second NHL goal was also a playoff game-winning goal, this time coming against the Washington Capitals on in Game 1 of the Eastern Conference Semi-finals on April 28, making him the first player in NHL history whose first two goals were playoff game-winners.
He ended the 2012 playoffs with five goals, an NHL record for most playoff goals before playing his first regular season game.
The prior record of four such goals was held by Eddie Mazur, and the prior record of three goals in a single post-season prior to playing a regular season game was held by George McPhee and Ray Cote.

Kreider scored his first career hat-trick on November 30, 2013, against the Vancouver Canucks in a 5–2 Rangers victory.

On May 17, 2014, in game one of the Eastern Conference Finals against the Montreal Canadiens, Kreider crashed the net of Canadien's goaltender, Carey Price, resulting in a Price sustaining a sprained knee.
 Price would miss the remainder the round of the playoffs.
 The Rangers would go on to claim a 4-2 series victory.

On July 23, 2014, Kreider and the Rangers agreed to a two-year, $4.95 million contract extension.

On October 28, 2014, in a game against the Minnesota Wild, Kreider received a major penalty and a game misconduct for dangerously checking Wild defenseman Jonas Brodin from behind into the boards.
Despite an injury to Brodin, Kreider was not suspended for the hit.

On July 22, 2016, Kreider signed a four-year, $18.5 million contract extension with the Rangers, avoiding arbitration.
Kreider would then have a solid 2016-17 season, setting new career highs in both goals (28) and points (53).

During a game against the Washington Capitals on December 27, 2017, Kreider left the game for an undisclosed reason.
It was later revealed that Kreider had a blood clot in his right arm, and would be out indefinitely.
On January 8, 2018, it was announced that Kreider would undergo rib resection surgery, and would be out of the lineup for about 5–7 weeks.
Kreider played his first game back on February 24, 2018 against the Minnesota Wild after missing 24 games.

On February 24, 2020, Kreider signed a seven-year, $45.5 million contract extension with the Rangers.
On April 10, 2012, Kreider signed a three-year, entry-level contract with the Rangers. He joined New York the following day for practice, and was declared eligible to participate in the 2012 Stanley Cup playoffs. He made his NHL debut a few days later in a Game 3 of the Eastern Conference Quarter-finals on April 16, 2012. He scored his first career NHL goal in Game 6 of that series on April 23 with an assist from former World Junior Championship teammate Derek Stepan, which proved to be the game-winner.
Kreider's second NHL goal was also a playoff game-winning goal, this time coming against the Washington Capitals on in Game 1 of the Eastern Conference Semi-finals on April 28, making him the first player in NHL history whose first two goals were playoff game-winners. He ended the 2012 playoffs with five goals, an NHL record for most playoff goals before playing his first regular season game. The prior record of four such goals was held by Eddie Mazur, and the prior record of three goals in a single post-season prior to playing a regular season game was held by George McPhee and Ray Cote.
Kreider scored his first career hat-trick on November 30, 2013, against the Vancouver Canucks in a 5–2 Rangers victory.
On May 17, 2014, in game one of the Eastern Conference Finals against the Montreal Canadiens, Kreider crashed the net of Canadien's goaltender, Carey Price, resulting in a Price sustaining a sprained knee.  Price would miss the remainder the round of the playoffs.  The Rangers would go on to claim a 4-2 series victory.
On July 23, 2014, Kreider and the Rangers agreed to a two-year, $4.95 million contract extension.
On October 28, 2014, in a game against the Minnesota Wild, Kreider received a major penalty and a game misconduct for dangerously checking Wild defenseman Jonas Brodin from behind into the boards. Despite an injury to Brodin, Kreider was not suspended for the hit.
On July 22, 2016, Kreider signed a four-year, $18.5 million contract extension with the Rangers, avoiding arbitration. Kreider would then have a solid 2016-17 season, setting new career highs in both goals (28) and points (53).
During a game against the Washington Capitals on December 27, 2017, Kreider left the game for an undisclosed reason. It was later revealed that Kreider had a blood clot in his right arm, and would be out indefinitely. On January 8, 2018, it was announced that Kreider would undergo rib resection surgery, and would be out of the lineup for about 5–7 weeks. Kreider played his first game back on February 24, 2018 against the Minnesota Wild after missing 24 games.
On February 24, 2020, Kreider signed a seven-year, $45.5 million contract extension with the Rangers.
Chris Kreider