The Python was originally available in two finishes: royal blue and bright nickel.
The bright nickel model was discontinued with the introduction of the more durable satin stainless and mirror-polished Ultimate Stainless models.
The stainless steel and royal blue finishes were offered until 2003 by Colt on the Python "Elite" model.

Pythons were available with 2.5-inch (6.4 cm), 3-inch (7.6 cm), 4-inch (10 cm), 6-inch (15 cm) and 8-inch (20 cm) barrels.
The six-inch model was the most popular generally, and the eight-inch model was intended for hunting.
A three-inch barrel version is very collectible, although not rare.

The Python Hunter model, with eight-inch barrel and factory-installed 2X Leupold scope, was made in 1980.
The Python Hunter was the first field-ready handgun hunting package made by a major handgun manufacturer.
The scope was mounted on the barrel using Redfield mounts and the gun was packaged in a Haliburton case.
It was discontinued by 1990 and briefly offered as a "Custom Shop" model afterward.
A Python Target model was made for several years in .38 Special only, in blue and nickel finishes.

Two variants of the Python were made in small numbers by Colt.
The first was the Colt Boa of 1985, a limited production .357 Magnum revolver, made for the Lew Horton Distributing Company in Massachusetts.
It uses a Python barrel mated to a Trooper Mk V frame.
Six-hundred 6-inch revolvers and 600 four-inch revolvers were made, of which 100 were matched sets.
Though it resembles a Python visually, it is substantially different internally.
The second was the stainless steel Colt Grizzly of 1994, another limited production .357 Magnum revolver.
It uses a Python barrel mated to a Colt King Cobra frame.
Five-hundred of these revolvers were manufactured, with six-inch Magna-ported barrels and smooth, unfluted cylinders.
The ported barrel includes a bear footprint.
Similar to the Grizzly was the Colt Kodiak, which was a Colt Anaconda with a Magna-ported barrel and an unfluted cylinder.
Approximately 2000 Kodiaks were manufactured.

According to Colt historian, R. L. Wilson, Colt Pythons have been collected by Elvis Presley and various kings in the traditional sense: "H.M. (His Majesty) Hussein I of Jordan ordered a limited number of Pythons with 4-inch and 6-inch barrels, as gifts to his selected friends.
Casing and barrel were embossed with His Majesty's crest.
The Python for King Juan Carlos of Spain bore his name in flush gold on the sideplate.
Among other celebrated recipients: King Khalid and Prince Fahd (Saudi Arabia), King Hassan (Morocco), Sheik Zayed (United Arab Emirates), President Anwar Sadat (Egypt) and President Hafez Assad (Syria)."
The Python was originally available in two finishes: royal blue and bright nickel. The bright nickel model was discontinued with the introduction of the more durable satin stainless and mirror-polished Ultimate Stainless models. The stainless steel and royal blue finishes were offered until 2003 by Colt on the Python "Elite" model.
Pythons were available with 2.5-inch (6.4 cm), 3-inch (7.6 cm), 4-inch (10 cm), 6-inch (15 cm) and 8-inch (20 cm) barrels. The six-inch model was the most popular generally, and the eight-inch model was intended for hunting. A three-inch barrel version is very collectible, although not rare.
The Python Hunter model, with eight-inch barrel and factory-installed 2X Leupold scope, was made in 1980. The Python Hunter was the first field-ready handgun hunting package made by a major handgun manufacturer. The scope was mounted on the barrel using Redfield mounts and the gun was packaged in a Haliburton case. It was discontinued by 1990 and briefly offered as a "Custom Shop" model afterward. A Python Target model was made for several years in .38 Special only, in blue and nickel finishes.
Two variants of the Python were made in small numbers by Colt. The first was the Colt Boa of 1985, a limited production .357 Magnum revolver, made for the Lew Horton Distributing Company in Massachusetts. It uses a Python barrel mated to a Trooper Mk V frame. Six-hundred 6-inch revolvers and 600 four-inch revolvers were made, of which 100 were matched sets. Though it resembles a Python visually, it is substantially different internally. The second was the stainless steel Colt Grizzly of 1994, another limited production .357 Magnum revolver. It uses a Python barrel mated to a Colt King Cobra frame. Five-hundred of these revolvers were manufactured, with six-inch Magna-ported barrels and smooth, unfluted cylinders. The ported barrel includes a bear footprint. Similar to the Grizzly was the Colt Kodiak, which was a Colt Anaconda with a Magna-ported barrel and an unfluted cylinder. Approximately 2000 Kodiaks were manufactured.
According to Colt historian, R. L. Wilson, Colt Pythons have been collected by Elvis Presley and various kings in the traditional sense: "H.M. (His Majesty) Hussein I of Jordan ordered a limited number of Pythons with 4-inch and 6-inch barrels, as gifts to his selected friends. Casing and barrel were embossed with His Majesty's crest. The Python for King Juan Carlos of Spain bore his name in flush gold on the sideplate. Among other celebrated recipients: King Khalid and Prince Fahd (Saudi Arabia), King Hassan (Morocco), Sheik Zayed (United Arab Emirates), President Anwar Sadat (Egypt) and President Hafez Assad (Syria)."
Colt Python