I-75 crosses the eastern portion of the Upper Peninsula from the Straits of Mackinac on the south to Sault Ste.
Marie and the border with Canada on the north.
There it connects with the Sault Ste.
Marie International Bridge across to Sault Ste.
Marie, Ontario.

 US 2 crosses into Michigan from Wisconsin at Ironwood and runs east to Crystal Falls, where it dips back into Wisconsin.
The highway crosses back into Michigan for a second time at Iron Mountain and runs east to its terminus at St. Ignace.

 US 8 enters the state from Wisconsin at Dickinson County's Norway township, crossing the Menominee River and proceeding north into the city of Norway where it ends at US 2.

 US 41 enters at Menominee and goes north to Copper Harbor.

 US 45 crosses into Michigan south of Watersmeet and ends in Ontonagon.

 US 141 enters the state south of Quinnesec.
US 141 runs concurrently with US 2 through the Iron Mountain area and crosses back into Wisconsin.
US 141 separates from US 2 at Crystal Falls and runs north to US 41 at Covington in Baraga County.

 M-28 runs from Wakefield east across the UP to south of Sault Ste.
Marie.
 At 290.373 miles (467.310 km) in length, it is the state's longest trunkline with an M- prefix.

 M-35 runs from Menominee north to Negaunee.

 M-26 runs from Rockland north to Copper Harbor.

 M-123 runs from St. Ignace north and then makes a southward U-turn before terminating at Newberry.

The U.S. Forest Service and Federal Highway Administration have designated certain roads within the several National Forests in the UP as Federal Forest Highways.
State-maintained highways closest to the Upper Peninsula's Great Lakes shorelines are marked by the Michigan Department of Transportation (MDOT) with signs indicating that they are part of the Great Lakes Circle Tour, a designated scenic road system connecting all of the Great Lakes and the St. Lawrence River.
MDOT has also designated five UP highways as Pure Michigan Byways for their historic, recreational or scenic qualities.
They are: US 2 in Iron County (Iron County Heritage Trail) and in Schoolcraft and Mackinac counties (Top of the Lake Scenic Byway), US 41 from Houghton to Copper Harbor (Copper County Trail, also a National Scenic Byway), M-35 (UP Hidden Coast Recreational Heritage Trail), M-123 (Tahquamenon Scenic Heritage Route) and M-134 (M-134 North Huron Byway)
I-75 crosses the eastern portion of the Upper Peninsula from the Straits of Mackinac on the south to Sault Ste. Marie and the border with Canada on the north. There it connects with the Sault Ste. Marie International Bridge across to Sault Ste. Marie, Ontario.
 US 2 crosses into Michigan from Wisconsin at Ironwood and runs east to Crystal Falls, where it dips back into Wisconsin. The highway crosses back into Michigan for a second time at Iron Mountain and runs east to its terminus at St. Ignace.
 US 8 enters the state from Wisconsin at Dickinson County's Norway township, crossing the Menominee River and proceeding north into the city of Norway where it ends at US 2.
 US 41 enters at Menominee and goes north to Copper Harbor.
 US 45 crosses into Michigan south of Watersmeet and ends in Ontonagon.
 US 141 enters the state south of Quinnesec. US 141 runs concurrently with US 2 through the Iron Mountain area and crosses back into Wisconsin. US 141 separates from US 2 at Crystal Falls and runs north to US 41 at Covington in Baraga County.
 M-28 runs from Wakefield east across the UP to south of Sault Ste. Marie.  At 290.373 miles (467.310 km) in length, it is the state's longest trunkline with an M- prefix.
 M-35 runs from Menominee north to Negaunee.
 M-26 runs from Rockland north to Copper Harbor.
 M-123 runs from St. Ignace north and then makes a southward U-turn before terminating at Newberry.
The U.S. Forest Service and Federal Highway Administration have designated certain roads within the several National Forests in the UP as Federal Forest Highways. State-maintained highways closest to the Upper Peninsula's Great Lakes shorelines are marked by the Michigan Department of Transportation (MDOT) with signs indicating that they are part of the Great Lakes Circle Tour, a designated scenic road system connecting all of the Great Lakes and the St. Lawrence River. MDOT has also designated five UP highways as Pure Michigan Byways for their historic, recreational or scenic qualities. They are: US 2 in Iron County (Iron County Heritage Trail) and in Schoolcraft and Mackinac counties (Top of the Lake Scenic Byway), US 41 from Houghton to Copper Harbor (Copper County Trail, also a National Scenic Byway), M-35 (UP Hidden Coast Recreational Heritage Trail), M-123 (Tahquamenon Scenic Heritage Route) and M-134 (M-134 North Huron Byway)
Upper Peninsula of Michigan