The hospital is located on a large block bound by Main Street, Booth Memorial Avenue, 141st Street, and 56th Avenue.
It consists of five multi-story buildings, with a parking lot located across Booth Memorial Avenue.
The main entrance and lobby are located on Main Street at the southwest end of the block, while the emergency entrance is located on Booth Memorial.
The only non-hospital structure on the block is a Speedway LLC filling station (formerly branded as a Hess Corporation station) on the northwest corner, which is currently being demolished and turned into a parking lot.

In 1999, a major modernization project took place, adding 200 beds to the hospital.
A second major expansion of the facility was approved by Queens Community Board 7 in September 2006, leading to the construction of the current lobby building and a new West Wing building.
Groundbreaking on the project took place on February 9, 2007.
The West Wing opened in 2010.
A new parking garage, either on the current parking lot or on property taken from nearby Kissena Corridor Park, was proposed, but has yet to be constructed.
In 2012, the hospital installed a half-acre of green roof with funding from the New York City Department of Environmental Protection.

In addition to the main facility, several other facilities, including primary and specialty care facilities, are located across Queens, particularly in nearby Flushing and Fresh Meadows.
The hospital is located on a large block bound by Main Street, Booth Memorial Avenue, 141st Street, and 56th Avenue. It consists of five multi-story buildings, with a parking lot located across Booth Memorial Avenue. The main entrance and lobby are located on Main Street at the southwest end of the block, while the emergency entrance is located on Booth Memorial. The only non-hospital structure on the block is a Speedway LLC filling station (formerly branded as a Hess Corporation station) on the northwest corner, which is currently being demolished and turned into a parking lot. 
In 1999, a major modernization project took place, adding 200 beds to the hospital. A second major expansion of the facility was approved by Queens Community Board 7 in September 2006, leading to the construction of the current lobby building and a new West Wing building. Groundbreaking on the project took place on February 9, 2007. The West Wing opened in 2010. A new parking garage, either on the current parking lot or on property taken from nearby Kissena Corridor Park, was proposed, but has yet to be constructed. In 2012, the hospital installed a half-acre of green roof with funding from the New York City Department of Environmental Protection.
In addition to the main facility, several other facilities, including primary and specialty care facilities, are located across Queens, particularly in nearby Flushing and Fresh Meadows.
NewYork–Presbyterian Queens