US-400 and US-50 enter Kansas west of Coolidge.
They run concurrently through Garden City, where it intersects US-83 and separate at Dodge City, which is where it intersects US-56 and US-283.
It continues southeast from Dodge City and first intersects US-54 at Mullinville.

US-400 and US-54 begin a long concurrency at Mullinville which passes through Greensburg, Pratt and Kingman before entering Wichita.
While in Wichita, US-400 and US-54 intersect Interstate 235 and the concurrency of US-81 and Interstate 135.
K-96 provides a short freeway connection to Interstate 35, which is also the Kansas Turnpike.
At Augusta, US-400 and US-54 enter into another concurrency with US-77, and US-400 breaks from this concurrency at Haverhill.

US-400 continues east through several small towns before turning southeast to go through the Fredonia area and intersecting US-75 at Neodesha.
After a brief concurrency with US-75, it turns east, first intersecting U.S. Route 169 near Morehead and then US-59 near Parsons before finally intersecting US-69 south of Pittsburg.
It then turns south with US-69 and at Crestline, follows US-69A south to Riverton.
US-400 then turns east with US-166 at Baxter Springs and the two highways run concurrently eastward into Missouri.
US-400 and US-50 enter Kansas west of Coolidge. They run concurrently through Garden City, where it intersects US-83 and separate at Dodge City, which is where it intersects US-56 and US-283. It continues southeast from Dodge City and first intersects US-54 at Mullinville.
US-400 and US-54 begin a long concurrency at Mullinville which passes through Greensburg, Pratt and Kingman before entering Wichita. While in Wichita, US-400 and US-54 intersect Interstate 235 and the concurrency of US-81 and Interstate 135. K-96 provides a short freeway connection to Interstate 35, which is also the Kansas Turnpike. At Augusta, US-400 and US-54 enter into another concurrency with US-77, and US-400 breaks from this concurrency at Haverhill.
US-400 continues east through several small towns before turning southeast to go through the Fredonia area and intersecting US-75 at Neodesha. After a brief concurrency with US-75, it turns east, first intersecting U.S. Route 169 near Morehead and then US-59 near Parsons before finally intersecting US-69 south of Pittsburg. It then turns south with US-69 and at Crestline, follows US-69A south to Riverton. US-400 then turns east with US-166 at Baxter Springs and the two highways run concurrently eastward into Missouri.
U.S. Route 400