Glutathione reductase (GR) catalyzes the reduction of glutathione disulfide (GSSG) to glutathione (GSH).
GR requires FAD and NADPH to facilitate this reaction; first a hydride must be transferred from NADPH to FAD.
The reduced flavin can then act as a nucleophile to attack the disulfide, this forms the C4a-cysteine adduct.
Elimination of this adduct results in a flavin-thiolate charge-transfer complex.
Glutathione reductase (GR) catalyzes the reduction of glutathione disulfide (GSSG) to glutathione (GSH). GR requires FAD and NADPH to facilitate this reaction; first a hydride must be transferred from NADPH to FAD. The reduced flavin can then act as a nucleophile to attack the disulfide, this forms the C4a-cysteine adduct. Elimination of this adduct results in a flavin-thiolate charge-transfer complex.
Flavin adenine dinucleotide