Patrick was selected by NASA as an astronaut candidate in June 1998 and reported to NASA's Johnson Space Center (JSC) for astronaut training in August 1998.
His initial training included scientific and technical briefings, intensive instruction in Shuttle and International Space Station systems, and physiological, survival, and classroom training in preparation for T-38 flight.

Patrick has logged over 308 hours in space, having completed his first space mission as a member of the crew of STS-116 – a construction and logistics mission to the International Space Station.
He occasionally serves as a CAPCOM; for example, he worked with the Orbit 2 team for STS-120.

Patrick notably put the finishing touches on the Tranquility node during STS-130.

In July 2004, Patrick served as an aquanaut during the NEEMO 6 mission aboard the Aquarius underwater laboratory, living and working underwater for ten days.
 In August 2007, he served as the commander of the NEEMO 13 mission, living underwater for another ten days.

Patrick retired from the NASA Astronaut Corps in May 2012.
Patrick was selected by NASA as an astronaut candidate in June 1998 and reported to NASA's Johnson Space Center (JSC) for astronaut training in August 1998. His initial training included scientific and technical briefings, intensive instruction in Shuttle and International Space Station systems, and physiological, survival, and classroom training in preparation for T-38 flight.
Patrick has logged over 308 hours in space, having completed his first space mission as a member of the crew of STS-116 – a construction and logistics mission to the International Space Station. He occasionally serves as a CAPCOM; for example, he worked with the Orbit 2 team for STS-120.
Patrick notably put the finishing touches on the Tranquility node during STS-130.
In July 2004, Patrick served as an aquanaut during the NEEMO 6 mission aboard the Aquarius underwater laboratory, living and working underwater for ten days.  In August 2007, he served as the commander of the NEEMO 13 mission, living underwater for another ten days.
Patrick retired from the NASA Astronaut Corps in May 2012.
Nicholas Patrick