Incumbent Republican Edward Martin did not seek re-election.
The Republican nominee, Hugh Scott, defeated the term-limited Democratic Governor of Pennsylvania George M. Leader for the vacant seat.

Scott would be twice re-elected, rising to the Senate Minority leader, and serve until retiring in 1977.
 Leader retired from public service after the defeat.
Incumbent Republican Edward Martin did not seek re-election. The Republican nominee, Hugh Scott, defeated the term-limited Democratic Governor of Pennsylvania George M. Leader for the vacant seat.
Scott would be twice re-elected, rising to the Senate Minority leader, and serve until retiring in 1977.  Leader retired from public service after the defeat.
1958 United States Senate elections