On August 28, 2006, Collins agreed to a one-year contract with the Tennessee Titans.
After three games, all losses for the Titans, Collins had completed fewer than half his passes, and had thrown one touchdown and six interceptions.
Vince Young, who played extensively as a substitute in the second game, started the fourth through sixth games while Collins saw no playing time in any of them.
On March 5, 2007, he re-signed with the Titans.

After Young was injured against Jacksonville on September 7, 2008, Collins finished the game and was named the Titans starting quarterback for the rest of 2008 later that week.
On September 21, 2008, Collins became the 15th player in NFL history to pass for more than 35,000 yards.
Coming into the game against the Houston Texans, Collins needed only 90 yards to eclipse the mark.
On his ninth completion of 13 attempts, Collins completed a 17-yard pass to Justin McCareins to give him 107 yards on the day and 35,017 yards for his career.

The Titans finished the 2008 regular season with a record of 13–3, top seed in the playoffs, and a first round bye.
In the divisional round they lost to the Baltimore Ravens 13–10.
A last minute field goal by Matt Stover won the game for the Ravens.
 Collins indicated after the season that he would like to play in 2009, but only as a starter.
Collins replaced Jets quarterback Brett Favre in the 2009 Pro Bowl, after first alternate Philip Rivers pulled out.
He re-signed with the Titans on February 27, 2009.
His new contract was worth $15 million, with $8.5 million guaranteed over two years.

Collins returned as the team's starting quarterback for the beginning of the 2009 season.
In week six the Titans were defeated by the New England Patriots 59–0.
After that loss and a 0–6 record on the season, coach Jeff Fisher replaced Collins as starting quarterback with Vince Young, three days before the November 1, 2009 game against the Jacksonville Jaguars.
Fisher stated that he was against this decision, saying that the problems with the team were unrelated to quarterback play, but he made the substitution after being urged by Titans owner Bud Adams to do so.
The Titans won five straight games with Young as quarterback, and later finished the season 8–8.

Collins officially announced his retirement from the NFL on July 7, 2011.
On August 28, 2006, Collins agreed to a one-year contract with the Tennessee Titans. After three games, all losses for the Titans, Collins had completed fewer than half his passes, and had thrown one touchdown and six interceptions. Vince Young, who played extensively as a substitute in the second game, started the fourth through sixth games while Collins saw no playing time in any of them. On March 5, 2007, he re-signed with the Titans.
After Young was injured against Jacksonville on September 7, 2008, Collins finished the game and was named the Titans starting quarterback for the rest of 2008 later that week. On September 21, 2008, Collins became the 15th player in NFL history to pass for more than 35,000 yards. Coming into the game against the Houston Texans, Collins needed only 90 yards to eclipse the mark. On his ninth completion of 13 attempts, Collins completed a 17-yard pass to Justin McCareins to give him 107 yards on the day and 35,017 yards for his career.
The Titans finished the 2008 regular season with a record of 13–3, top seed in the playoffs, and a first round bye. In the divisional round they lost to the Baltimore Ravens 13–10. A last minute field goal by Matt Stover won the game for the Ravens.  Collins indicated after the season that he would like to play in 2009, but only as a starter. Collins replaced Jets quarterback Brett Favre in the 2009 Pro Bowl, after first alternate Philip Rivers pulled out. He re-signed with the Titans on February 27, 2009. His new contract was worth $15 million, with $8.5 million guaranteed over two years.
Collins returned as the team's starting quarterback for the beginning of the 2009 season. In week six the Titans were defeated by the New England Patriots 59–0. After that loss and a 0–6 record on the season, coach Jeff Fisher replaced Collins as starting quarterback with Vince Young, three days before the November 1, 2009 game against the Jacksonville Jaguars. Fisher stated that he was against this decision, saying that the problems with the team were unrelated to quarterback play, but he made the substitution after being urged by Titans owner Bud Adams to do so. The Titans won five straight games with Young as quarterback, and later finished the season 8–8.
Collins officially announced his retirement from the NFL on July 7, 2011.
Kerry Collins