Neshek signed a minor league deal with the St. Louis Cardinals on February 6, 2014, with an invitation to spring training and an opportunity as a right-handed specialist against right-handed batters from the bullpen.
 After the mixed performances of the previous two seasons and less-than-satisfying offers from other teams, he had worked during the offseason specifically to target an increase in fastball velocity.
 This followed after the New York Mets commented to him they wanted to see increased velocity.
 It gradually surged, showing up to 92 miles per hour (148 km/h), up from a consistent 87–88 miles per hour (140–142 km/h) from the year before.
 Pleased with the increased velocity, the Cardinals purchased his contract on March 30, thereby awarding him a spot on the 25-man MLB roster.

The developments with Neshek's spring training led to further success in the regular season that occurred as he began to mix more pitches with his slider.
 Against 48 total batters faced in April, he struck out 16 and yielded just six hits along with a 1.42 ERA.
 Neshek was credited with his first win as a Cardinal when he pitched two scoreless innings against the Arizona Diamondbacks on May 22.
 Neshek improved in his second month as a Cardinal, allowing just five hits and yielding no runs in 12 IP in May.  He picked up his first career MLB save on June 4 against the Kansas City Royals.
 In another eight IP in June, Neshek allowed just one run with a .143 batting average against.
 During a 22-game span, he yielded no runs, covering ​20 ¹⁄₃ innings.
 His fastball average for the season through June 30 was 90.1 miles per hour (145.0 km/h), the highest of his career.
 Through that point, sliders comprised 38 percent of his total pitches.

After emerging from the role of a right-handed specialist to primary setup pitcher for closer Trevor Rosenthal, Neshek made his first All-Star Game.
 In 43 games and ​38 ¹⁄₃ IP before the midseason break, he was 4–0 with two saves, a 0.70 ERA, and 0.57 walks plus hits per inning pitched (WHIP).
 By making the team, he became just the 15th non-starter or closer of 280 total pitchers of the prior ten seasons to be named to an All-Star team.
 Further, the All-Star selection was a personal landmark event in two ways.
 First, the game was played at Target Field in Minneapolis, the home field of the Twins, the team with whom Neshek began his MLB career.
Second, it was close to Brooklyn Park, the city in which he grew up.
 However, Neshek took the loss for the National League, as the American League won, 5–3.

The Cardinals traded for John Lackey at the non-waiver deadline on July 31, and Neshek volunteered to change his number from 41 to 37.
 Lackey had worn 41 with past teams.
 To facilitate the exchange, Lackey mailed Neshek a Babe Ruth–autographed baseball the next month.
 In an August 10 appearance against the Orioles, Neshek's sinker was clocked at 93 miles per hour (150 km/h) as he completed two innings and struck out four, tying a career high.
 On August 19 against the Cincinnati Reds, he worked the last inning and picked up the decision in a Cardinals' walk-off win.
 It was his sixth win of the year against zero losses.
 For the month, he registered two saves and two wins.
 In 2014 he was 7–2 with six saves and a 1.87 ERA, and 68 strikeouts in 67​¹⁄₃ innings.
Despite having only given up 4 home runs the entire season, Neshek surrendered a postseason game-losing home run in Game 2 of the 2014 National League Division Series to Matt Kemp of the Los Angeles Dodgers and  the game-tying home run in Game 5 of the 2014 National League Championship Series to Michael Morse of the San Francisco Giants, which ultimately lead to the elimination of the Cardinals in the 2014 postseason.
Neshek signed a minor league deal with the St. Louis Cardinals on February 6, 2014, with an invitation to spring training and an opportunity as a right-handed specialist against right-handed batters from the bullpen.  After the mixed performances of the previous two seasons and less-than-satisfying offers from other teams, he had worked during the offseason specifically to target an increase in fastball velocity.  This followed after the New York Mets commented to him they wanted to see increased velocity.  It gradually surged, showing up to 92 miles per hour (148 km/h), up from a consistent 87–88 miles per hour (140–142 km/h) from the year before.  Pleased with the increased velocity, the Cardinals purchased his contract on March 30, thereby awarding him a spot on the 25-man MLB roster.
The developments with Neshek's spring training led to further success in the regular season that occurred as he began to mix more pitches with his slider.  Against 48 total batters faced in April, he struck out 16 and yielded just six hits along with a 1.42 ERA.  Neshek was credited with his first win as a Cardinal when he pitched two scoreless innings against the Arizona Diamondbacks on May 22.  Neshek improved in his second month as a Cardinal, allowing just five hits and yielding no runs in 12 IP in May.  He picked up his first career MLB save on June 4 against the Kansas City Royals.  In another eight IP in June, Neshek allowed just one run with a .143 batting average against.  During a 22-game span, he yielded no runs, covering ​20 ¹⁄₃ innings.  His fastball average for the season through June 30 was 90.1 miles per hour (145.0 km/h), the highest of his career.  Through that point, sliders comprised 38 percent of his total pitches.
After emerging from the role of a right-handed specialist to primary setup pitcher for closer Trevor Rosenthal, Neshek made his first All-Star Game.  In 43 games and ​38 ¹⁄₃ IP before the midseason break, he was 4–0 with two saves, a 0.70 ERA, and 0.57 walks plus hits per inning pitched (WHIP).  By making the team, he became just the 15th non-starter or closer of 280 total pitchers of the prior ten seasons to be named to an All-Star team.  Further, the All-Star selection was a personal landmark event in two ways.  First, the game was played at Target Field in Minneapolis, the home field of the Twins, the team with whom Neshek began his MLB career. Second, it was close to Brooklyn Park, the city in which he grew up.  However, Neshek took the loss for the National League, as the American League won, 5–3.
The Cardinals traded for John Lackey at the non-waiver deadline on July 31, and Neshek volunteered to change his number from 41 to 37.  Lackey had worn 41 with past teams.  To facilitate the exchange, Lackey mailed Neshek a Babe Ruth–autographed baseball the next month.  In an August 10 appearance against the Orioles, Neshek's sinker was clocked at 93 miles per hour (150 km/h) as he completed two innings and struck out four, tying a career high.  On August 19 against the Cincinnati Reds, he worked the last inning and picked up the decision in a Cardinals' walk-off win.  It was his sixth win of the year against zero losses.  For the month, he registered two saves and two wins.  In 2014 he was 7–2 with six saves and a 1.87 ERA, and 68 strikeouts in 67​¹⁄₃ innings. Despite having only given up 4 home runs the entire season, Neshek surrendered a postseason game-losing home run in Game 2 of the 2014 National League Division Series to Matt Kemp of the Los Angeles Dodgers and  the game-tying home run in Game 5 of the 2014 National League Championship Series to Michael Morse of the San Francisco Giants, which ultimately lead to the elimination of the Cardinals in the 2014 postseason.
Pat Neshek