In 1848, Schoellkopf married Sofie Christiane Duerr (1827–1903), who was also born in Germany and came to the United States in 1842.
Four of his children died in infancy and two suffered health problems and died within two years of their father.
Their children who lived to adulthood were:
Henry Schoellkopf (1848–1880), who married Emily Vogel in 1875.

Louis Schoellkopf (1855–1901), who married Myra Lee Horton (1861–1910).

Arthur Schoellkopf (1856–1913), who served as the 5th mayor of Niagara Falls
Jacob F. Schoellkopf Jr. (1858–1942), who married Wilma Spring.

Alfred Schoellkopf (1860–1901), who married Emily R. Graebe (1869–1951).

Charles Philip Hugo Schoellkopf (1862–1928), who married Emily F. Annette of Fort Lee, New Jersey.

Helen Schoellkopf (1870–1962), who married Hans Schmidt (president of "J.F. Schoellkopf Co.")
Schoellkopf died "one of Buffalo's wealthiest and best known citizens" in Buffalo, New York on September 15, 1899.
 Christiana died four years later on October 13, 1903.
In 1848, Schoellkopf married Sofie Christiane Duerr (1827–1903), who was also born in Germany and came to the United States in 1842. Four of his children died in infancy and two suffered health problems and died within two years of their father. Their children who lived to adulthood were:
Henry Schoellkopf (1848–1880), who married Emily Vogel in 1875.
Louis Schoellkopf (1855–1901), who married Myra Lee Horton (1861–1910).
Arthur Schoellkopf (1856–1913), who served as the 5th mayor of Niagara Falls
Jacob F. Schoellkopf Jr. (1858–1942), who married Wilma Spring.
Alfred Schoellkopf (1860–1901), who married Emily R. Graebe (1869–1951).
Charles Philip Hugo Schoellkopf (1862–1928), who married Emily F. Annette of Fort Lee, New Jersey.
Helen Schoellkopf (1870–1962), who married Hans Schmidt (president of "J.F. Schoellkopf Co.")
Schoellkopf died "one of Buffalo's wealthiest and best known citizens" in Buffalo, New York on September 15, 1899.  Christiana died four years later on October 13, 1903.
Jacob F. Schoellkopf