The film was a box-office success, grossing $2,000,000 domestically with a budget of $200,000.
Variety's "Bige" gave She Done Him Wrong a negative review stating that Paramount was attempting to rush Mae West to stardom by giving her her own film and top billing, and that the film was not very good without known actors and an entertaining story.

She Done Him Wrong was nominated for an Academy Award for Outstanding Production, now known as Best Picture.
At 66 minutes, it is the shortest film ever to be so honored.

In 1996, She Done Him Wrong was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant".

The film is recognized by American Film Institute in these lists:
1998: AFI's 100 Years...100 Movies – Nominated
2000: AFI's 100 Years...100 Laughs – #75
2004: AFI's 100 Years...100 Songs:
"Frankie and Johnny" – Nominated
2005: AFI's 100 Years...100 Movie Quotes:
Lady Lou: "Why don't you come up sometime and see me?" – #
26
2007: AFI's 100 Years...100 Movies (10th Anniversary Edition) – Nominated
The film was a box-office success, grossing $2,000,000 domestically with a budget of $200,000. Variety's "Bige" gave She Done Him Wrong a negative review stating that Paramount was attempting to rush Mae West to stardom by giving her her own film and top billing, and that the film was not very good without known actors and an entertaining story.
She Done Him Wrong was nominated for an Academy Award for Outstanding Production, now known as Best Picture. At 66 minutes, it is the shortest film ever to be so honored.
In 1996, She Done Him Wrong was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant".
The film is recognized by American Film Institute in these lists:
1998: AFI's 100 Years...100 Movies – Nominated
2000: AFI's 100 Years...100 Laughs – #75
2004: AFI's 100 Years...100 Songs:
"Frankie and Johnny" – Nominated
2005: AFI's 100 Years...100 Movie Quotes:
Lady Lou: "Why don't you come up sometime and see me?" – #26
2007: AFI's 100 Years...100 Movies (10th Anniversary Edition) – Nominated
She Done Him Wrong