Detroit optioned Scherzer to the Triple-A Toledo Mud Hens on May 16, replacing him with Armando Galarraga.
 Shortly thereafter, Scherzer was recalled to the major leagues for good, going 6–4 in twelve starts with an ERA of 2.62 and 85 strikeouts in 75​²⁄₃ innings.

On May 30 versus the Oakland Athletics, Scherzer accumulated 14 strikeouts in ​5 ²⁄₃ innings pitched.
 It was the fourth time in his career that he had 10 or more strikeouts in a single game.
 He allowed two hits, four walks, and hit a batter on his last pitch.
 That mark was tied for the most strikeouts in Comerica Park history with Jeremy Bonderman, and tied for second in franchise history behind Mickey Lolich, who had 16 strikeouts in one game.
 On July 26, Scherzer and Tampa Bay Rays pitcher Matt Garza dueled for a no-hitter into the sixth inning.
 After ​5 ²⁄₃ hitless innings, Scherzer lost the no-hit bid, shutout, and game after serving up a grand slam to Matt Joyce.
 Meanwhile, Garza opportunely secured the no-hitter in a 5–0 Tampa win.
 Scherzer struck out eight.

On September 1 against the Minnesota Twins, Scherzer pitched into the ninth inning for the first time in his career.
 He gave up one run on four hits and one walk while striking out nine on 107 pitches, though he received a no-decision as the Tigers lost the game in the tenth inning.

Scherzer finished the 2010 season with a 12–11 record, 3.50 ERA and 184 strikeouts.
 Despite spending some time in the minor leagues, his strikeout total was still good for tenth in the American League.
Detroit optioned Scherzer to the Triple-A Toledo Mud Hens on May 16, replacing him with Armando Galarraga.  Shortly thereafter, Scherzer was recalled to the major leagues for good, going 6–4 in twelve starts with an ERA of 2.62 and 85 strikeouts in 75​²⁄₃ innings.
On May 30 versus the Oakland Athletics, Scherzer accumulated 14 strikeouts in ​5 ²⁄₃ innings pitched.  It was the fourth time in his career that he had 10 or more strikeouts in a single game.  He allowed two hits, four walks, and hit a batter on his last pitch.  That mark was tied for the most strikeouts in Comerica Park history with Jeremy Bonderman, and tied for second in franchise history behind Mickey Lolich, who had 16 strikeouts in one game.  On July 26, Scherzer and Tampa Bay Rays pitcher Matt Garza dueled for a no-hitter into the sixth inning.  After ​5 ²⁄₃ hitless innings, Scherzer lost the no-hit bid, shutout, and game after serving up a grand slam to Matt Joyce.  Meanwhile, Garza opportunely secured the no-hitter in a 5–0 Tampa win.  Scherzer struck out eight.
On September 1 against the Minnesota Twins, Scherzer pitched into the ninth inning for the first time in his career.  He gave up one run on four hits and one walk while striking out nine on 107 pitches, though he received a no-decision as the Tigers lost the game in the tenth inning.
Scherzer finished the 2010 season with a 12–11 record, 3.50 ERA and 184 strikeouts.  Despite spending some time in the minor leagues, his strikeout total was still good for tenth in the American League.
Max Scherzer