In December 2004, Podsednik was dealt to the Chicago White Sox (along with Travis Hinton and Luis Vizcaíno) for Carlos Lee.
 After leading all of the Major Leagues in steals the first half of 2005 he was selected to his first All-Star game via the MLB's All-Star Final Vote.
 He saw only defensive time in the All-Star game in Detroit that year and did not get a chance to bat.

Podsednik ended 2005 with 59 steals (second in the American League) and 23 times caught stealing (leading the major leagues) despite missing several games due to injury.
 In the post-season he started all 12 games and hit .286 while stealing 6 bases on 9 attempts.
In Game 2 of the 2005 World Series, while facing Brad Lidge in the bottom of the 9th inning, with the White Sox and Astros tied at 6, Podsednik hit a 2-1 fastball into the right field stands for a walk-off home run, only the 14th in World Series history.
 The feat was all the more improbable because Podsednik did not hit any home runs during the regular season in 2005, and had only hit 1 in the ALDS against the Red Sox.
Two days later in Game 3, he set a World Series record of eight at-bats in a single World Series Game.

In 2006, Podsednik once again led the league with 19 times caught stealing.

On November 20, 2007, Podsednik was designated for assignment and released on November 28, 2007.
In December 2004, Podsednik was dealt to the Chicago White Sox (along with Travis Hinton and Luis Vizcaíno) for Carlos Lee.  After leading all of the Major Leagues in steals the first half of 2005 he was selected to his first All-Star game via the MLB's All-Star Final Vote.  He saw only defensive time in the All-Star game in Detroit that year and did not get a chance to bat.
Podsednik ended 2005 with 59 steals (second in the American League) and 23 times caught stealing (leading the major leagues) despite missing several games due to injury.  In the post-season he started all 12 games and hit .286 while stealing 6 bases on 9 attempts. In Game 2 of the 2005 World Series, while facing Brad Lidge in the bottom of the 9th inning, with the White Sox and Astros tied at 6, Podsednik hit a 2-1 fastball into the right field stands for a walk-off home run, only the 14th in World Series history.  The feat was all the more improbable because Podsednik did not hit any home runs during the regular season in 2005, and had only hit 1 in the ALDS against the Red Sox. Two days later in Game 3, he set a World Series record of eight at-bats in a single World Series Game.
In 2006, Podsednik once again led the league with 19 times caught stealing.
On November 20, 2007, Podsednik was designated for assignment and released on November 28, 2007.
Scott Podsednik