Santa Rosa is traversed by South Luzon Expressway (SLEX) and Cavite–Laguna Expressway (CALAX).
Two exits of SLEX are located in the city, namely: Santa Rosa Exit and Eton City (Malitlit) Exit.
The city is also accessible through Greenfield City (Mamplasan) Exit in Biñan, which provides access to CALAX, SM City Santa Rosa, and the Santa Rosa city proper.
Two exits of CALAX directly serve the city, namely: Santa Rosa City Exit, located in Barangay Carmen, Silang, Cavite, and the unopened Laguna Boulevard Exit, located within the city.
A four-lane national highway from Alabang, Muntinlupa up to Calamba, Laguna passes through the city.
Another road, Santa Rosa-Tagaytay Road, acts as the main route for people going up to Tagaytay from Metro Manila, especially on weekends and vacation periods.

Public transportation within the city, like in most of the urban areas in the Philippines, is facilitated mostly using inexpensive jeepneys.
Tricycles are also used for short distances.
In Laguna BelAir subdivision, residents uses exclusive multicab shuttles within the village complex.
The Santa Rosa railway station is located in barangay Labas, near the city center.
The city is also the location of the Santa Rosa Commercial Complex, a well-known inter-modal transport and commercial hub in Barangay Balibago, and the Santa Rosa Integrated Terminal, a provincial bus station serving Metro Manila and eventually other parts south of Metro Manila.
Santa Rosa is traversed by South Luzon Expressway (SLEX) and Cavite–Laguna Expressway (CALAX). Two exits of SLEX are located in the city, namely: Santa Rosa Exit and Eton City (Malitlit) Exit. The city is also accessible through Greenfield City (Mamplasan) Exit in Biñan, which provides access to CALAX, SM City Santa Rosa, and the Santa Rosa city proper. Two exits of CALAX directly serve the city, namely: Santa Rosa City Exit, located in Barangay Carmen, Silang, Cavite, and the unopened Laguna Boulevard Exit, located within the city. A four-lane national highway from Alabang, Muntinlupa up to Calamba, Laguna passes through the city. Another road, Santa Rosa-Tagaytay Road, acts as the main route for people going up to Tagaytay from Metro Manila, especially on weekends and vacation periods.
Public transportation within the city, like in most of the urban areas in the Philippines, is facilitated mostly using inexpensive jeepneys. Tricycles are also used for short distances. In Laguna BelAir subdivision, residents uses exclusive multicab shuttles within the village complex. The Santa Rosa railway station is located in barangay Labas, near the city center. The city is also the location of the Santa Rosa Commercial Complex, a well-known inter-modal transport and commercial hub in Barangay Balibago, and the Santa Rosa Integrated Terminal, a provincial bus station serving Metro Manila and eventually other parts south of Metro Manila.
Santa Rosa, Laguna