Ralph began her career on the stage, and was nominated in 1982 for a Tony Award for Best Actress in a Musical for her role as Deena Jones in Dreamgirls.
In 1984, Ralph released her only album In the Evening, in which the title track peaked at No.
6 on the Billboard Dance Music/Club Play Singles chart that same year.
 In 1988 she starred in the Disney movie Oliver & Company, providing the voice of Rita.
Her first leading role in a film came as Denzel Washington's wife in The Mighty Quinn, released in 1989.
In 1992 she starred with Robert De Niro in the title role in Mistress.
That same year, she co-starred with Eddie Murphy in The Distinguished Gentleman.
During the 1990s she also had roles in The Flintstones, Deterrence, and Unconditional Love.

On television, she was in the cast of the CBS daytime soap opera Search for Tomorrow while starring on Broadway in Dreamgirls.
 She is known for playing Ginger St. James on It's a Living, Etienne Toussaint-Bouvier on Designing Women, and Dee Mitchell on Moesha.
 She provided the voice of Cheetah in Justice League and Justice League Unlimited.
She also played Florence Watson, the mother of Rita Louise Watson (Lauryn Hill) in the 1993 film Sister Act 2: Back in the Habit.
Ralph produced Divas Simply Singing, which has become an important AIDS fundraiser.
She also appeared on the Showtime series Barbershop as Claire.
Sheryl brought a new face to the sufferings of war in the NBC hit series ER.
Ralph's 2002 project Baby of the Family concerns a young child who is born with a caul over her head, which enables her to see ghosts and the future.
Ralph was also featured with son Etienne on MTV's My Super Sweet 16 and BET's Baldwin Hills, as well as an episode of Clean House that also featured her two children, Etienne and Ivy-Victoria (aka Coco), named after Ralph's mother.

On June 16, 2009, it was announced that Ralph would join the cast of the Broadway-bound musical The First Wives Club as Elyse.
She replaced Adriane Lenox, who withdrew from the show due to health concerns.
In 2011, Ralph guest-starred in the Young Justice episode "Terrors" as Amanda Waller.
In 2013, Ralph appeared in the NBC television show Smash as Cynthia, the mother of Jennifer Hudson's character.
On February 9, 2013, Ralph appeared at the 2013 Columbus Middle School youth rally in Columbus, Mississippi.
In August 2014, she appeared on KTLA Los Angeles Morning News as a fill-in Entertainment Reporter.
In November 2014, Ralph appeared on Nicky, Ricky, Dicky, and Dawn as the rich lady who claims her dog from Nicky, Ricky, Dicky, and Dawn.

Some of her recent TV appearances include the TNT dramedy Claws, and on the Nickelodeon sitcom Instant Mom as Stephanie's (Tia Mowry-Hardrict's) mother.

From January 10 to April 11, 2019 Ralph appeared as one of the main characters, "Rose" in the television series "Fam" which ran for one season & was canceled in May 2019.
Ralph began her career on the stage, and was nominated in 1982 for a Tony Award for Best Actress in a Musical for her role as Deena Jones in Dreamgirls. In 1984, Ralph released her only album In the Evening, in which the title track peaked at No. 6 on the Billboard Dance Music/Club Play Singles chart that same year.  In 1988 she starred in the Disney movie Oliver & Company, providing the voice of Rita. Her first leading role in a film came as Denzel Washington's wife in The Mighty Quinn, released in 1989. In 1992 she starred with Robert De Niro in the title role in Mistress. That same year, she co-starred with Eddie Murphy in The Distinguished Gentleman. During the 1990s she also had roles in The Flintstones, Deterrence, and Unconditional Love.
On television, she was in the cast of the CBS daytime soap opera Search for Tomorrow while starring on Broadway in Dreamgirls.  She is known for playing Ginger St. James on It's a Living, Etienne Toussaint-Bouvier on Designing Women, and Dee Mitchell on Moesha.  She provided the voice of Cheetah in Justice League and Justice League Unlimited. She also played Florence Watson, the mother of Rita Louise Watson (Lauryn Hill) in the 1993 film Sister Act 2: Back in the Habit. Ralph produced Divas Simply Singing, which has become an important AIDS fundraiser. She also appeared on the Showtime series Barbershop as Claire. Sheryl brought a new face to the sufferings of war in the NBC hit series ER. Ralph's 2002 project Baby of the Family concerns a young child who is born with a caul over her head, which enables her to see ghosts and the future. Ralph was also featured with son Etienne on MTV's My Super Sweet 16 and BET's Baldwin Hills, as well as an episode of Clean House that also featured her two children, Etienne and Ivy-Victoria (aka Coco), named after Ralph's mother.
On June 16, 2009, it was announced that Ralph would join the cast of the Broadway-bound musical The First Wives Club as Elyse. She replaced Adriane Lenox, who withdrew from the show due to health concerns. In 2011, Ralph guest-starred in the Young Justice episode "Terrors" as Amanda Waller. In 2013, Ralph appeared in the NBC television show Smash as Cynthia, the mother of Jennifer Hudson's character. On February 9, 2013, Ralph appeared at the 2013 Columbus Middle School youth rally in Columbus, Mississippi. In August 2014, she appeared on KTLA Los Angeles Morning News as a fill-in Entertainment Reporter. In November 2014, Ralph appeared on Nicky, Ricky, Dicky, and Dawn as the rich lady who claims her dog from Nicky, Ricky, Dicky, and Dawn.
Some of her recent TV appearances include the TNT dramedy Claws, and on the Nickelodeon sitcom Instant Mom as Stephanie's (Tia Mowry-Hardrict's) mother.
From January 10 to April 11, 2019 Ralph appeared as one of the main characters, "Rose" in the television series "Fam" which ran for one season & was canceled in May 2019.
Sheryl Lee Ralph