The venue hosts a variety of events, ranging from concerts to weddings.
According to Willamette Week's Sophie June, Holocene "began as one of the only spots to bring national-caliber electronic acts to Portland following the fast demise of the B Complex".
In her guides to Portland, Rachel Dresbeck said the venue hosts many "musical experiences—secret shows by famous artists, up-and-coming bands that will be famous shortly, veteran and nouveau DJs, house music, shoegaze, modern soul, and other musical attractions keeping hipsters crowding the place".

Musicians who have performed at Holocene include Against the Current, Lauren Aquilina, Au/Ra, Beach Fossils, Ryan Beatty, Kadhja Bonet, Clairo, Crumb, Matthew Dear, Duckwrth, Future Generations, Tommy Genesis, Chuck Inglish, Japanese Breakfast, The Japanese House, Jonna Lee, Milk & Bone, Shy Girls, Sasha Sloan, Snail Mail, Tove Styrke, Avey Tare, and Zaytoven.
The venue hosted London Grammar's first concert in Portland.
In 2018, Holocene hosted a "Club Kai Kai Pride" event featuring drag performer Aja.
The event was part of the "Club Kai Kai" series, which caters to the LGBT community and features "a rave-style club scene with plenty of drag royalty, voguing and butterflies for the stomach".
The venue has also hosted writers, including Shayla Lawson.
In 2019, the Portland-based literary magazine Tin House hosted an event in conjunction with the Association of Writers & Writing Programs (AWP) conference, featuring readings by Hanif Abdurraqib, Erica Dawson, Morgan Parker, and Tommy Pico.

Monthly events include "Double Down" (described as a "hot and sweaty queer-friendly dance party") and "Slay", a "queer-centric" hip-hop event catering to an "intersectional crowd".
Recurring dance events include "Cupcake" ("devoted to 'fat folks and allies'") and "Snap!",
a 1990s music party "designed to evoke middle-school dances".
Others include "Candi Pop" (bubblegum pop), "Emo Nite", "Gaycation", a Rolling Stones-themed party called "Sympathy for the Disco",  and another dedicated to the Talking Heads.
The venue hosted StorySLAM monthly as of 2018.

Holocene hosted the "Ping Pong Pandemonium Party" in mid-2010; participants included Fred Armisen and Carrie Brownstein and Janet Weiss of Sleater-Kinney.
More recent tribute events have included "Beyoncé Nicki Rihanna Night", "Holla!: '
90s vs Early '00s Rap & RNB Night", "This Party Is Killing You: All Robyn All Night" and "Cake for Drake", where cake was served for Drake's birthday.
In 2018, the venue was decorated to resemble the Sunnydale nightclub from Buffy the Vampire Slayer as part of a Halloween celebration and hosted Jo Ann Hardesty's election-results viewing party.
Holocene hosted Girl Fest the following year, and was one of several venues screening films as part of the Portland Oregon Women's Film Festival (POW Fest).
The venue hosts a variety of events, ranging from concerts to weddings. According to Willamette Week's Sophie June, Holocene "began as one of the only spots to bring national-caliber electronic acts to Portland following the fast demise of the B Complex". In her guides to Portland, Rachel Dresbeck said the venue hosts many "musical experiences—secret shows by famous artists, up-and-coming bands that will be famous shortly, veteran and nouveau DJs, house music, shoegaze, modern soul, and other musical attractions keeping hipsters crowding the place".
Musicians who have performed at Holocene include Against the Current, Lauren Aquilina, Au/Ra, Beach Fossils, Ryan Beatty, Kadhja Bonet, Clairo, Crumb, Matthew Dear, Duckwrth, Future Generations, Tommy Genesis, Chuck Inglish, Japanese Breakfast, The Japanese House, Jonna Lee, Milk & Bone, Shy Girls, Sasha Sloan, Snail Mail, Tove Styrke, Avey Tare, and Zaytoven. The venue hosted London Grammar's first concert in Portland. In 2018, Holocene hosted a "Club Kai Kai Pride" event featuring drag performer Aja. The event was part of the "Club Kai Kai" series, which caters to the LGBT community and features "a rave-style club scene with plenty of drag royalty, voguing and butterflies for the stomach". The venue has also hosted writers, including Shayla Lawson. In 2019, the Portland-based literary magazine Tin House hosted an event in conjunction with the Association of Writers & Writing Programs (AWP) conference, featuring readings by Hanif Abdurraqib, Erica Dawson, Morgan Parker, and Tommy Pico.
Monthly events include "Double Down" (described as a "hot and sweaty queer-friendly dance party") and "Slay", a "queer-centric" hip-hop event catering to an "intersectional crowd". Recurring dance events include "Cupcake" ("devoted to 'fat folks and allies'") and "Snap!", a 1990s music party "designed to evoke middle-school dances". Others include "Candi Pop" (bubblegum pop), "Emo Nite", "Gaycation", a Rolling Stones-themed party called "Sympathy for the Disco",  and another dedicated to the Talking Heads. The venue hosted StorySLAM monthly as of 2018.
Holocene hosted the "Ping Pong Pandemonium Party" in mid-2010; participants included Fred Armisen and Carrie Brownstein and Janet Weiss of Sleater-Kinney. More recent tribute events have included "Beyoncé Nicki Rihanna Night", "Holla!: '90s vs Early '00s Rap & RNB Night", "This Party Is Killing You: All Robyn All Night" and "Cake for Drake", where cake was served for Drake's birthday. In 2018, the venue was decorated to resemble the Sunnydale nightclub from Buffy the Vampire Slayer as part of a Halloween celebration and hosted Jo Ann Hardesty's election-results viewing party. Holocene hosted Girl Fest the following year, and was one of several venues screening films as part of the Portland Oregon Women's Film Festival (POW Fest).
Holocene (Portland, Oregon)