On July 26, 2008, Blake was traded from the Indians to the Los Angeles Dodgers for minor league players Carlos Santana and Jon Meloan.
He went 2 for 3 with a double and a run scored in his debut with the Dodgers on July 26.
He hit his first home run with the Dodgers on August 2, 2008.
Blake hit .251 with 10 home runs in 58 games with the Dodgers in 2008 and on December 9, signed a three-year extension with the club for $17 million.

In 2009, he hit .280 with 18 home runs for the Dodgers and his fielding percentage was the best all-time for a Dodger third baseman.

In 2010, he hit .248, his lowest average since 2005, with 17 home runs and 64 RBI.

Due to various injuries, Blake was only able to appear in 63 games for the Dodgers in 2011, hitting .252 with only 4 home runs, his lowest total since 2002.
On September 1, he decided to undergo season-ending surgery on his neck to relieve the pain from a pinched nerve that had bothered him all season.

On October 4, 2011, the Dodgers declined Blake's 2012 option, instead paying him a buyout of $1.25 million and making him a free agent.
On July 26, 2008, Blake was traded from the Indians to the Los Angeles Dodgers for minor league players Carlos Santana and Jon Meloan. He went 2 for 3 with a double and a run scored in his debut with the Dodgers on July 26. He hit his first home run with the Dodgers on August 2, 2008. Blake hit .251 with 10 home runs in 58 games with the Dodgers in 2008 and on December 9, signed a three-year extension with the club for $17 million.
In 2009, he hit .280 with 18 home runs for the Dodgers and his fielding percentage was the best all-time for a Dodger third baseman.
In 2010, he hit .248, his lowest average since 2005, with 17 home runs and 64 RBI.
Due to various injuries, Blake was only able to appear in 63 games for the Dodgers in 2011, hitting .252 with only 4 home runs, his lowest total since 2002. On September 1, he decided to undergo season-ending surgery on his neck to relieve the pain from a pinched nerve that had bothered him all season.
On October 4, 2011, the Dodgers declined Blake's 2012 option, instead paying him a buyout of $1.25 million and making him a free agent.
Casey Blake