The follow-up expedition, the Second India Armada, launched in 1500 under the command of Pedro Álvares Cabral with the mission of making a treaty with the Zamorin of Calicut and setting up a Portuguese factory in the city.
However, Pedro Cabral entered into a conflict with the local Arab merchant guilds, with the result that the Portuguese factory was overrun in a riot and up to 70 Portuguese were killed.
Cabral blamed the Zamorin for the incident and bombarded the city.
Thus war broke out between Portugal and Calicut.

Vasco da Gama invoked his royal letter to take command of the 4th India Armada, scheduled to set out in 1502, with the explicit aim of taking revenge upon the Zamorin and force him to submit to Portuguese terms.
 The heavily armed fleet of fifteen ships and eight hundred men left Lisbon on 12 February 1502.
 It was followed in April by another squadron of five ships led by his cousin, Estêvão da Gama (the son of Aires da Gama), which caught up to them in the Indian Ocean.
 The 4th Armada was a veritable da Gama family affair.
 Two of his maternal uncles, Vicente Sodré and Brás Sodré, were pre-designated to command an Indian Ocean naval patrol, while brothers-in-law Álvaro de Ataíde (brother of Vasco's wife Catarina) and Lopo Mendes de Vasconcelos (betrothed to Teresa da Gama, Vasco's sister) captained ships in the main fleet.

On the outgoing voyage, da Gama's fleet opened contact with the East African gold trading port of Sofala and reduced the sultanate of Kilwa to tribute, extracting a substantial sum of gold.
On reaching India in October 1502, da Gama's fleet set about capturing any Arab vessel he came across in Indian waters, most notoriously the Miri, a pilgrim ship from Mecca, whose passengers he massacred in open water.
 He then appeared before Calicut, demanding redress for the treatment of Cabral.
While the Zamorin was willing to sign a new treaty, da Gama made a call to the Hindu king to expel all Muslims from Calicut before beginning negotiations, which was turned down.
The Portuguese fleet then bombarded the city for nearly two days from the sea shore, severely damaging the unfortified city.
He also captured several rice vessels and cut off the crew's hands, ears and noses, dispatching them with an insulting note to the Zamorin.

The violent treatment meted out by da Gama quickly brought trade along the Malabar Coast of India, upon which Calicut depended, to a standstill.
 But the Zamorin nonetheless refused to submit to Portuguese terms, and even ventured to hire a fleet of strong warships to challenge da Gama's armada (which da Gama managed to defeat in a naval battle before Calicut harbor).
Da Gama loaded up with spices at Cochin and Cannanore, small nearby kingdoms, half-vassal and half-at-war with the Zamorin, whose alliances had been secured by prior Portuguese fleets.
The 4th armada left India in early 1503.
Da Gama left behind a small squadron of caravels under the command of his uncle, Vicente Sodré, to patrol the Indian coast, to continue harassing Calicut shipping, and to protect the Portuguese factories at Cochin and Cannanore from the Zamorin's inevitable reprisals.

Vasco da Gama arrived back in Portugal in September 1503, effectively having failed in his mission to bring the Zamorin to submission.
This failure, and the subsequent more galling failure of his uncle Vicente Sodré to protect the Portuguese factory in Cochin, probably counted against any further rewards.
When the Portuguese king Manuel I of Portugal decided to appoint the first governor and viceroy of Portuguese India in 1505, da Gama was conspicuously overlooked, and the post given to Francisco de Almeida.
The follow-up expedition, the Second India Armada, launched in 1500 under the command of Pedro Álvares Cabral with the mission of making a treaty with the Zamorin of Calicut and setting up a Portuguese factory in the city. However, Pedro Cabral entered into a conflict with the local Arab merchant guilds, with the result that the Portuguese factory was overrun in a riot and up to 70 Portuguese were killed. Cabral blamed the Zamorin for the incident and bombarded the city. Thus war broke out between Portugal and Calicut.
Vasco da Gama invoked his royal letter to take command of the 4th India Armada, scheduled to set out in 1502, with the explicit aim of taking revenge upon the Zamorin and force him to submit to Portuguese terms.  The heavily armed fleet of fifteen ships and eight hundred men left Lisbon on 12 February 1502.  It was followed in April by another squadron of five ships led by his cousin, Estêvão da Gama (the son of Aires da Gama), which caught up to them in the Indian Ocean.  The 4th Armada was a veritable da Gama family affair.  Two of his maternal uncles, Vicente Sodré and Brás Sodré, were pre-designated to command an Indian Ocean naval patrol, while brothers-in-law Álvaro de Ataíde (brother of Vasco's wife Catarina) and Lopo Mendes de Vasconcelos (betrothed to Teresa da Gama, Vasco's sister) captained ships in the main fleet.
On the outgoing voyage, da Gama's fleet opened contact with the East African gold trading port of Sofala and reduced the sultanate of Kilwa to tribute, extracting a substantial sum of gold. On reaching India in October 1502, da Gama's fleet set about capturing any Arab vessel he came across in Indian waters, most notoriously the Miri, a pilgrim ship from Mecca, whose passengers he massacred in open water.  He then appeared before Calicut, demanding redress for the treatment of Cabral. While the Zamorin was willing to sign a new treaty, da Gama made a call to the Hindu king to expel all Muslims from Calicut before beginning negotiations, which was turned down. The Portuguese fleet then bombarded the city for nearly two days from the sea shore, severely damaging the unfortified city. He also captured several rice vessels and cut off the crew's hands, ears and noses, dispatching them with an insulting note to the Zamorin.
The violent treatment meted out by da Gama quickly brought trade along the Malabar Coast of India, upon which Calicut depended, to a standstill.  But the Zamorin nonetheless refused to submit to Portuguese terms, and even ventured to hire a fleet of strong warships to challenge da Gama's armada (which da Gama managed to defeat in a naval battle before Calicut harbor). Da Gama loaded up with spices at Cochin and Cannanore, small nearby kingdoms, half-vassal and half-at-war with the Zamorin, whose alliances had been secured by prior Portuguese fleets. The 4th armada left India in early 1503. Da Gama left behind a small squadron of caravels under the command of his uncle, Vicente Sodré, to patrol the Indian coast, to continue harassing Calicut shipping, and to protect the Portuguese factories at Cochin and Cannanore from the Zamorin's inevitable reprisals.
Vasco da Gama arrived back in Portugal in September 1503, effectively having failed in his mission to bring the Zamorin to submission. This failure, and the subsequent more galling failure of his uncle Vicente Sodré to protect the Portuguese factory in Cochin, probably counted against any further rewards. When the Portuguese king Manuel I of Portugal decided to appoint the first governor and viceroy of Portuguese India in 1505, da Gama was conspicuously overlooked, and the post given to Francisco de Almeida.
Vasco da Gama