Paul Revere's famous midnight ride traveled along Main Street, continuing onto High Street in Medford Square.
An annual re-enactment takes place honoring the historic event.

The Peter Tufts House (350 Riverside Ave.)
is thought to be the oldest all-brick building in New England.
Another important site is the "Slave Wall" on Grove Street, built by "Pomp," a slave owned by the prominent Brooks family.
The Isaac Royall House, which once belonged to one of Harvard Law School's founders, Isaac Royall, Jr., is a National Historic Landmark and a local history museum.
The house was used by Continental Army troops, including George Washington and John Stark, during the American Revolutionary War.

George Luther Stearns, an American industrialist and one of John Brown's Secret Six.
His passion for the abolitionist cause shaped his life, bringing him into contact with the likes of Abraham Lincoln and Ralph Waldo Emerson and starting The Nation magazine.
He was given the rank of major by Massachusetts Governor John Andrew and spent most of the Civil War recruiting for the 54th and 55th Massachusetts regiments and the 5th cavalry.

Medford was home to Fannie Farmer, author of one of the world's most famous cookbooks—as well as James Plimpton, the man credited with the 1863 invention of the first practical four-wheeled roller skate, which set off a roller craze that quickly spread across the United States and Europe.

Amelia Earhart lived in Medford while working as a social worker in 1925.

Elizabeth Short, the victim of an infamous Hollywood murder and who became known as The Black Dahlia, was born in Hyde Park (the southernmost neighborhood of the city of Boston, Massachusetts) but raised in Medford before going to the West Coast looking for fame.

Medford has sent more than its share of athletes to the National Hockey League; Shawn Bates, though born in Melrose, MA grew up in Medford, as did Keith Tkachuk, Mike Morrison, David Sacco, and Joe Sacco.
Former Red Sox pitcher Bill Monbouquette grew up in Medford, as did former Major League Baseball infielder Mike Pagliarulo.

Medford was home to Michael Bloomberg, American businessman, philanthropist, and the founder of Bloomberg L.P.. He was the Mayor of New York City from 2002 to 2013.
Mayor Bloomberg attended Medford High School and resided in Medford until after he graduated from college at Johns Hopkins University.
His mother remained a resident of Medford until her death in 2011.

The only cryobank of amniotic stem cells in the United States is located in Medford, built by Biocell Center, a biotechnology company led by Giuseppe Simoni.
Paul Revere's famous midnight ride traveled along Main Street, continuing onto High Street in Medford Square. An annual re-enactment takes place honoring the historic event.
The Peter Tufts House (350 Riverside Ave.) is thought to be the oldest all-brick building in New England. Another important site is the "Slave Wall" on Grove Street, built by "Pomp," a slave owned by the prominent Brooks family. The Isaac Royall House, which once belonged to one of Harvard Law School's founders, Isaac Royall, Jr., is a National Historic Landmark and a local history museum. The house was used by Continental Army troops, including George Washington and John Stark, during the American Revolutionary War.
George Luther Stearns, an American industrialist and one of John Brown's Secret Six. His passion for the abolitionist cause shaped his life, bringing him into contact with the likes of Abraham Lincoln and Ralph Waldo Emerson and starting The Nation magazine. He was given the rank of major by Massachusetts Governor John Andrew and spent most of the Civil War recruiting for the 54th and 55th Massachusetts regiments and the 5th cavalry.
Medford was home to Fannie Farmer, author of one of the world's most famous cookbooks—as well as James Plimpton, the man credited with the 1863 invention of the first practical four-wheeled roller skate, which set off a roller craze that quickly spread across the United States and Europe.
Amelia Earhart lived in Medford while working as a social worker in 1925.
Elizabeth Short, the victim of an infamous Hollywood murder and who became known as The Black Dahlia, was born in Hyde Park (the southernmost neighborhood of the city of Boston, Massachusetts) but raised in Medford before going to the West Coast looking for fame.
Medford has sent more than its share of athletes to the National Hockey League; Shawn Bates, though born in Melrose, MA grew up in Medford, as did Keith Tkachuk, Mike Morrison, David Sacco, and Joe Sacco. Former Red Sox pitcher Bill Monbouquette grew up in Medford, as did former Major League Baseball infielder Mike Pagliarulo.
Medford was home to Michael Bloomberg, American businessman, philanthropist, and the founder of Bloomberg L.P.. He was the Mayor of New York City from 2002 to 2013. Mayor Bloomberg attended Medford High School and resided in Medford until after he graduated from college at Johns Hopkins University. His mother remained a resident of Medford until her death in 2011.
The only cryobank of amniotic stem cells in the United States is located in Medford, built by Biocell Center, a biotechnology company led by Giuseppe Simoni.
Medford, Massachusetts