Collins provided lead vocals for the Fatboy Slim song "Weapon of Choice" from his 2000 album Halfway Between the Gutter and the Stars.
 Collins vocals quote the book Dune ("Walk without rhythm and you won't attract the worm").
 The song won multiple MTV Video Music Awards and a Grammy Award for Best Music Video.

In October 2005, Collins co-wrote a song celebrating the resurgence of his hometown team, the Cincinnati Bengals of the National Football League called "Fear Da Tiger" which features "raps" written and performed by several Bengals players, including defensive end Duane Clemons, offensive tackle Stacy Andrews, and center Ben Wilkerson.
 An edited version of the song was made into a music video which features cameos by many other Bengals players.
Collins appeared with Little Richard, Bernie Worrell, and other notable musicians as the band playing with Hank Williams, Jr. for the Monday Night Football opening during for the 2006 season.
Collins was the only all star to return with Williams for the 2007 season.

He also sings "Marshal Law", the theme song of the Cincinnati Marshals indoor football team and debuted the song in 2006 at half time of the April 29 Marshals home game against the West Palm Beach Phantoms.

In 2006, ABC Entertainment/ A Charly Films Release released a DVD and CD from Collins and the New Rubber Band's concert at the 1998 North Sea Jazz Festival.
Soon after the release, Collins split from long-time friend and guitarist Odhran "The Bodhran" Rameriz, citing creative differences as the reason.

Later that same year, Collins released the holiday album Christmas Is 4 Ever.
This represents the first Christmas-themed album made by any member of the P-Funk musical collective.
The album features re-workings of Christmas standards as well as original compositions.

In April 2007, Collins announced plans to open Bootsy's, a restaurant/club with Cincinnati area restaurateur Jeff Ruby.
 The venue operated from 2008 to 2010.
It featured live musical acts, a museum dedicated to Collins's musical career and Spanish, Central and South American cuisine.

In June 2007, Collins, along with Phelps Collins, Clyde Stubblefield, John "Jabo" Starks, and Bernie Worrell, participated in the recording of the soundtrack for the movie Superbad.
 In December of that year they (sans Worrell) went on to perform the first tribute concert remembering James Brown.

In July 2007, Collins also told Billboard magazine that he was working on a project by the name of Science Faxtion and an album called Living on Another Frequency in which he serves as bassist and co-producer along with his lead vocalist Greg Hampton.
The band also features guitarist Buckethead and drummer Brain.
The album was released in November 2008.

Collins promoted Rock the Vote for its 2008 campaign together with Buckethead.

Collins portrayed a radio DJ in the 2013 video game, Grand Theft Auto V, in which several of his own songs were featured.

Collins has also collaborated extensively with Bill Laswell and also frequently collaborated with fellow bassist Victor Wooten.

On December 14, 2018 Collins played a show with Detroit-based funk artist GRiZ, and also collaborated on a new song with GRiZ.
In January 2019, Collins announced on Facebook that he would be retiring from live performances for health reasons:
"Time has come for Me to tell all our Funkateers that I will Not be Playing Bass in Concerts anymore.
I have decided to become a Coach for up & coming Musicians.
I know u r Disappointed just think for a moment how I feel.
Doc said to much pressure on my Inner-Ear & Right Hand.
Yeah, I had to make up my Mind, so I did.
2019 Sheriff Ping Ping Ping will continue to Funk from the Studio but Not Live playing Bass on Stage.
I know u got question & I don't have answers, maybe one day u to will understand.
Just remember; That This Year will be the Funkiest Year of them All.
Watch for it.
Bootsy baby!!!"

He wrote that he would be releasing a new album this year, and that he would continue to work in the studio and mentor young musicians.
Collins provided lead vocals for the Fatboy Slim song "Weapon of Choice" from his 2000 album Halfway Between the Gutter and the Stars.  Collins vocals quote the book Dune ("Walk without rhythm and you won't attract the worm").  The song won multiple MTV Video Music Awards and a Grammy Award for Best Music Video.
In October 2005, Collins co-wrote a song celebrating the resurgence of his hometown team, the Cincinnati Bengals of the National Football League called "Fear Da Tiger" which features "raps" written and performed by several Bengals players, including defensive end Duane Clemons, offensive tackle Stacy Andrews, and center Ben Wilkerson.  An edited version of the song was made into a music video which features cameos by many other Bengals players. Collins appeared with Little Richard, Bernie Worrell, and other notable musicians as the band playing with Hank Williams, Jr. for the Monday Night Football opening during for the 2006 season. Collins was the only all star to return with Williams for the 2007 season.
He also sings "Marshal Law", the theme song of the Cincinnati Marshals indoor football team and debuted the song in 2006 at half time of the April 29 Marshals home game against the West Palm Beach Phantoms.
In 2006, ABC Entertainment/ A Charly Films Release released a DVD and CD from Collins and the New Rubber Band's concert at the 1998 North Sea Jazz Festival. Soon after the release, Collins split from long-time friend and guitarist Odhran "The Bodhran" Rameriz, citing creative differences as the reason.
Later that same year, Collins released the holiday album Christmas Is 4 Ever. This represents the first Christmas-themed album made by any member of the P-Funk musical collective. The album features re-workings of Christmas standards as well as original compositions.
In April 2007, Collins announced plans to open Bootsy's, a restaurant/club with Cincinnati area restaurateur Jeff Ruby.  The venue operated from 2008 to 2010. It featured live musical acts, a museum dedicated to Collins's musical career and Spanish, Central and South American cuisine.
In June 2007, Collins, along with Phelps Collins, Clyde Stubblefield, John "Jabo" Starks, and Bernie Worrell, participated in the recording of the soundtrack for the movie Superbad.  In December of that year they (sans Worrell) went on to perform the first tribute concert remembering James Brown.
In July 2007, Collins also told Billboard magazine that he was working on a project by the name of Science Faxtion and an album called Living on Another Frequency in which he serves as bassist and co-producer along with his lead vocalist Greg Hampton. The band also features guitarist Buckethead and drummer Brain. The album was released in November 2008.
Collins promoted Rock the Vote for its 2008 campaign together with Buckethead.
Collins portrayed a radio DJ in the 2013 video game, Grand Theft Auto V, in which several of his own songs were featured.
Collins has also collaborated extensively with Bill Laswell and also frequently collaborated with fellow bassist Victor Wooten.
On December 14, 2018 Collins played a show with Detroit-based funk artist GRiZ, and also collaborated on a new song with GRiZ.
In January 2019, Collins announced on Facebook that he would be retiring from live performances for health reasons:
"Time has come for Me to tell all our Funkateers that I will Not be Playing Bass in Concerts anymore. I have decided to become a Coach for up & coming Musicians. I know u r Disappointed just think for a moment how I feel. Doc said to much pressure on my Inner-Ear & Right Hand. Yeah, I had to make up my Mind, so I did. 2019 Sheriff Ping Ping Ping will continue to Funk from the Studio but Not Live playing Bass on Stage. I know u got question & I don't have answers, maybe one day u to will understand. Just remember; That This Year will be the Funkiest Year of them All. Watch for it. Bootsy baby!!!"
He wrote that he would be releasing a new album this year, and that he would continue to work in the studio and mentor young musicians.
Bootsy Collins