On December 13, 2013, the Tigers signed Chamberlain to a one-year contract, worth $2.5 million plus incentives.
Chamberlain began the year as the Tigers' set-up man.
Chamberlain earned a save on April 22, 2014, in an 8–6 win over the Chicago White Sox, which was only the 6th of his career.
Chamberlain was given the save opportunity after Phil Coke was handed an 8–3 lead and surrendered three runs, while closer Joe Nathan was given rest due to recent struggles.
Chamberlain finished the 2014 season with a 2–5 record and a 3.57 ERA, allowing 57 hits in 63 innings with 24 walks and 59 strikeouts.

On February 24, 2015, the Tigers re-signed Chamberlain to one-year, $1 million contract plus incentives.
He had a 1.26 ERA through May, but his ERA increased to 4.09 in his next ten appearances.
He allowed nine runs, eight earned, on 14 hits over 7​²⁄₃ innings since June 1.
He was designated for assignment by the Tigers on July 3.
On July 10, 2015, Chamberlain was given his unconditional release.
On December 13, 2013, the Tigers signed Chamberlain to a one-year contract, worth $2.5 million plus incentives. Chamberlain began the year as the Tigers' set-up man. Chamberlain earned a save on April 22, 2014, in an 8–6 win over the Chicago White Sox, which was only the 6th of his career. Chamberlain was given the save opportunity after Phil Coke was handed an 8–3 lead and surrendered three runs, while closer Joe Nathan was given rest due to recent struggles. Chamberlain finished the 2014 season with a 2–5 record and a 3.57 ERA, allowing 57 hits in 63 innings with 24 walks and 59 strikeouts.
On February 24, 2015, the Tigers re-signed Chamberlain to one-year, $1 million contract plus incentives. He had a 1.26 ERA through May, but his ERA increased to 4.09 in his next ten appearances. He allowed nine runs, eight earned, on 14 hits over 7​²⁄₃ innings since June 1. He was designated for assignment by the Tigers on July 3. On July 10, 2015, Chamberlain was given his unconditional release.
Joba Chamberlain