On 11 June 2001 Marcelo Fromer was rammed by a motorcycle in São Paulo and died two days later of Brain death.
It was a hard stroke to the band, which started recording their new album the day after.
A Melhor Banda de Todos os Tempos da Última Semana was released at the end of 2001 and brought "Epitáfio" as the prominence song and the title track as the first single.

Regarding the death of Marcelo, this statement was published on June 20, 2001 at Titãs official site:
Despite the pain that Marcelo's absence has caused, we have decided to enter the studio to record this record that we created and arranged together with him, about which we were - and still are - enthusiastic.
We feel that the best way to overcome this difficult moment is to continue with what always held us together: the music.
Once again, thanks for all the support and kindness from fans and friends.

In the following year, the band saw the departure of vocalist and bassist Nando Reis, who has since lead a successful solo career (including songs penned for other artists) fronting his own band Nando Reis e os Infernais.
He announced his parting on 9 September 9, 2002, giving "thought incompatibility" as a reason and also saying Fromer's and his close friend Cássia Eller's deaths left him very upset:
My decision of leaving the group is uniquely and exclusively due to a thought incompatibility regarding the future of the preparation of what would be our next album.
For believing that such work requires the total dedication that for personal reasons I cannot offer, we agreed it would be best for me to leave at the start of the preparation and the sessions.
I do it with deep regrets in my heart since in no moment I ever thought this would happen.

In a 2012 interview, he would say he didn't feel ready for the studio following his friends' deaths and three consecutive, exhausting tours.

The band hired the bass guitarist Lee Marcucci (from Rádio Táxi) to play in their first album without Reis, Como Estão Vocês? (
How Are You?).
With self-help hits as "Enquanto Houver Sol", questions on relevance remain on Titãs' side, which faced declining sales and the ageing of their fanbase.

In 2005, they released another MTV-branded album, only this time in a non-acoustic live performance.
This album generated a new hit for the group, called "Vossa Excelência", that basically criticizes the hypocrisy and lack of care from politicians, thus bringing the band back to its roots.

On February 18, 2006, Titãs opened the Rolling Stones free concert at Copacabana beach, Rio de Janeiro for an audience of some 1.5 million people.

In 2007, the band started a tour, entitled 25 Anos de Rock (25 Years of Rock), again joining Os Paralamas do Sucesso to celebrate the 25th anniversary of both bands, as well as the 25th anniversary of the rising of 1980s Brazilian rock bands.
The two line-ups played together most of the time on the shows, presenting also some invited musicians, like Arnaldo Antunes, Andreas Kisser and Dado Villa-Lobos.
The concert in Rio de Janeiro, which took place at January 26, 2008, was recorded and filmed.
The resulting collaborative CD and DVD were released five months after, titled Paralamas e Titãs Juntos e Ao Vivo .

The band released a documentary of the 25 years of their career.
The documentary features 90 minutes of images collected since the beginning of the band, including recording of albums, live performances, and more.
It is titled Titãs - A Vida Até Parece Uma Festa.

For most of 2008 and early 2009, the band recorded their 13th studio album, the Latin Grammy-winner Sacos Plásticos.
The album was released on June 3, 2009, through Arsenal Music.
The producer, Rick Bonadio, had already worked with artists such as Fresno and NX Zero.

The first single from the album was "Antes de Você" ("Before You"), and it received radio airplay on May 7.
It was featured at the Caras & Bocas (current 19pm Rede Globo telenovela) soundtrack.
The second single was "Porque Eu Sei que É Amor" (Because I Know It's Love) which was featured in Cama de Gato (a Brazilian telenovela that also
On 11 June 2001 Marcelo Fromer was rammed by a motorcycle in São Paulo and died two days later of Brain death. It was a hard stroke to the band, which started recording their new album the day after. A Melhor Banda de Todos os Tempos da Última Semana was released at the end of 2001 and brought "Epitáfio" as the prominence song and the title track as the first single.
Regarding the death of Marcelo, this statement was published on June 20, 2001 at Titãs official site:
Despite the pain that Marcelo's absence has caused, we have decided to enter the studio to record this record that we created and arranged together with him, about which we were - and still are - enthusiastic. We feel that the best way to overcome this difficult moment is to continue with what always held us together: the music. Once again, thanks for all the support and kindness from fans and friends.
In the following year, the band saw the departure of vocalist and bassist Nando Reis, who has since lead a successful solo career (including songs penned for other artists) fronting his own band Nando Reis e os Infernais. He announced his parting on 9 September 9, 2002, giving "thought incompatibility" as a reason and also saying Fromer's and his close friend Cássia Eller's deaths left him very upset:
My decision of leaving the group is uniquely and exclusively due to a thought incompatibility regarding the future of the preparation of what would be our next album. For believing that such work requires the total dedication that for personal reasons I cannot offer, we agreed it would be best for me to leave at the start of the preparation and the sessions. I do it with deep regrets in my heart since in no moment I ever thought this would happen.
In a 2012 interview, he would say he didn't feel ready for the studio following his friends' deaths and three consecutive, exhausting tours.
The band hired the bass guitarist Lee Marcucci (from Rádio Táxi) to play in their first album without Reis, Como Estão Vocês? (How Are You?). With self-help hits as "Enquanto Houver Sol", questions on relevance remain on Titãs' side, which faced declining sales and the ageing of their fanbase.
In 2005, they released another MTV-branded album, only this time in a non-acoustic live performance. This album generated a new hit for the group, called "Vossa Excelência", that basically criticizes the hypocrisy and lack of care from politicians, thus bringing the band back to its roots.
On February 18, 2006, Titãs opened the Rolling Stones free concert at Copacabana beach, Rio de Janeiro for an audience of some 1.5 million people.
In 2007, the band started a tour, entitled 25 Anos de Rock (25 Years of Rock), again joining Os Paralamas do Sucesso to celebrate the 25th anniversary of both bands, as well as the 25th anniversary of the rising of 1980s Brazilian rock bands. The two line-ups played together most of the time on the shows, presenting also some invited musicians, like Arnaldo Antunes, Andreas Kisser and Dado Villa-Lobos. The concert in Rio de Janeiro, which took place at January 26, 2008, was recorded and filmed. The resulting collaborative CD and DVD were released five months after, titled Paralamas e Titãs Juntos e Ao Vivo .
The band released a documentary of the 25 years of their career. The documentary features 90 minutes of images collected since the beginning of the band, including recording of albums, live performances, and more. It is titled Titãs - A Vida Até Parece Uma Festa.
For most of 2008 and early 2009, the band recorded their 13th studio album, the Latin Grammy-winner Sacos Plásticos. The album was released on June 3, 2009, through Arsenal Music. The producer, Rick Bonadio, had already worked with artists such as Fresno and NX Zero.
The first single from the album was "Antes de Você" ("Before You"), and it received radio airplay on May 7. It was featured at the Caras & Bocas (current 19pm Rede Globo telenovela) soundtrack. The second single was "Porque Eu Sei que É Amor" (Because I Know It's Love) which was featured in Cama de Gato (a Brazilian telenovela that also 
Titãs