From 2000 to 2002, Nye was the technical expert on BattleBots.
In 2004 and 2005, he hosted 100 Greatest Discoveries, an award-winning series produced by THINKFilm for The Science Channel, broadcast in high definition on the Discovery HD Theater network.
In 2007, he also hosted an eight-part Discovery Channel series, Greatest Inventions with Bill Nye.

A lecture Nye gave on getting children excited about math inspired the creation of the crime drama Numb3rs, where Nye appeared in several episodes as an engineering professor.
On October 28, 2007, he also made guest appearances on the VH1 reality show America's Most Smartest Model.

Nye appeared on segments of Heidi Cullen's The Climate Code, later renamed Forecast Earth on The Weather Channel, relating his personal ways of saving energy.
In the fall of 2008, he appeared periodically on the daytime game show Who Wants to Be a Millionaire as part of its "Ask the Expert" feature.

In 2008, Nye hosted Stuff Happens, a short-lived show on the Planet Green network.
In November 2008, he portrayed himself in the fifth-season episode "Brain Storm" of Stargate Atlantis, alongside fellow television personality and astrophysicist Neil deGrasse Tyson.

In October 2009, Nye recorded a short YouTube video (as himself, not his TV persona) advocating clean-energy climate-change legislation, on behalf of Al Gore's Repower America campaign.
He joined the American Optometric Association in a multimedia advertising campaign to persuade parents to provide their children with comprehensive eye examinations.

In 2013, Nye guest starred in The Big Bang Theory episode "The Proton Displacement."
In the episode, Sheldon Cooper befriends Nye and brings him in to teach Leonard Hofstadter a "lesson" after Professor Proton (played by Bob Newhart) helps Leonard with an experiment instead of Sheldon.
Professor Proton accuses Bill Nye of making his TV series similar to Proton's show.
After Nye and Sheldon leave, Leonard receives a selfie of the two having smoothies, and later gets a text from Sheldon asking for a ride home, as Nye has ditched him at the smoothie store.
In a later discussion with Professor Proton, Sheldon reveals that Nye had a restraining order against him, so he could not help him contact Nye.

On February 28, 2014, Nye was a celebrity guest and interviewer at the White House Student Film Festival.

On August 31, 2016, Netflix announced that Nye would appear in a new series, Bill Nye Saves the World, which premiered on April 21, 2017.
Nye appeared in the 2016 documentary Food Evolution, directed by Academy Award-nominated director Scott Hamilton Kennedy and narrated by Neil deGrasse Tyson.

In 2017, he was the subject of a biographical documentary film, Bill Nye: Science Guy, directed by David Alvarado and Jason Sussberg.
Nye was honorary co-chair of the inaugural March for Science on April 22, 2017.

In 2018, Nye guest-starred in an episode of Blindspot, "Let It Go", playing a fictionalized version of himself who is the father of the character Patterson.
Nye's fictional self also alludes to his rivalry with Rodney McKay, which was established in the aforementioned "Brain Storm" episode of Stargate Atlantis.
Also in 2018, Nye made a second guest appearance on The Big Bang Theory as himself, together with fellow scientist Neil deGrasse Tyson, in the first episode ("The Conjugal Configuration") of the show's final season.

In September 2019, Nye was a guest on Episode 127 of Jonathan Van Ness's podcast Getting Curious, where they discussed climate change, the failures of cold fusion, the potential of better battery technology for storage of energy produced by wind turbines and solar panels, the benefits of and forthcoming improvements to electric vehicles, and the detriment and failures of fossil fuel and nuclear energy, measures toward water cleanliness, the role of girls' and women's education in improving the environment, and the threat the Trump administration posed to the environment and to scientific thought in general.

Nye will also voice himself in the upcoming animated feature Happy Halloween
From 2000 to 2002, Nye was the technical expert on BattleBots. In 2004 and 2005, he hosted 100 Greatest Discoveries, an award-winning series produced by THINKFilm for The Science Channel, broadcast in high definition on the Discovery HD Theater network. In 2007, he also hosted an eight-part Discovery Channel series, Greatest Inventions with Bill Nye.
A lecture Nye gave on getting children excited about math inspired the creation of the crime drama Numb3rs, where Nye appeared in several episodes as an engineering professor. On October 28, 2007, he also made guest appearances on the VH1 reality show America's Most Smartest Model.
Nye appeared on segments of Heidi Cullen's The Climate Code, later renamed Forecast Earth on The Weather Channel, relating his personal ways of saving energy. In the fall of 2008, he appeared periodically on the daytime game show Who Wants to Be a Millionaire as part of its "Ask the Expert" feature.
In 2008, Nye hosted Stuff Happens, a short-lived show on the Planet Green network. In November 2008, he portrayed himself in the fifth-season episode "Brain Storm" of Stargate Atlantis, alongside fellow television personality and astrophysicist Neil deGrasse Tyson.
In October 2009, Nye recorded a short YouTube video (as himself, not his TV persona) advocating clean-energy climate-change legislation, on behalf of Al Gore's Repower America campaign. He joined the American Optometric Association in a multimedia advertising campaign to persuade parents to provide their children with comprehensive eye examinations.
In 2013, Nye guest starred in The Big Bang Theory episode "The Proton Displacement." In the episode, Sheldon Cooper befriends Nye and brings him in to teach Leonard Hofstadter a "lesson" after Professor Proton (played by Bob Newhart) helps Leonard with an experiment instead of Sheldon. Professor Proton accuses Bill Nye of making his TV series similar to Proton's show. After Nye and Sheldon leave, Leonard receives a selfie of the two having smoothies, and later gets a text from Sheldon asking for a ride home, as Nye has ditched him at the smoothie store. In a later discussion with Professor Proton, Sheldon reveals that Nye had a restraining order against him, so he could not help him contact Nye.
On February 28, 2014, Nye was a celebrity guest and interviewer at the White House Student Film Festival.
On August 31, 2016, Netflix announced that Nye would appear in a new series, Bill Nye Saves the World, which premiered on April 21, 2017. Nye appeared in the 2016 documentary Food Evolution, directed by Academy Award-nominated director Scott Hamilton Kennedy and narrated by Neil deGrasse Tyson.
In 2017, he was the subject of a biographical documentary film, Bill Nye: Science Guy, directed by David Alvarado and Jason Sussberg. Nye was honorary co-chair of the inaugural March for Science on April 22, 2017.
In 2018, Nye guest-starred in an episode of Blindspot, "Let It Go", playing a fictionalized version of himself who is the father of the character Patterson. Nye's fictional self also alludes to his rivalry with Rodney McKay, which was established in the aforementioned "Brain Storm" episode of Stargate Atlantis. Also in 2018, Nye made a second guest appearance on The Big Bang Theory as himself, together with fellow scientist Neil deGrasse Tyson, in the first episode ("The Conjugal Configuration") of the show's final season.
In September 2019, Nye was a guest on Episode 127 of Jonathan Van Ness's podcast Getting Curious, where they discussed climate change, the failures of cold fusion, the potential of better battery technology for storage of energy produced by wind turbines and solar panels, the benefits of and forthcoming improvements to electric vehicles, and the detriment and failures of fossil fuel and nuclear energy, measures toward water cleanliness, the role of girls' and women's education in improving the environment, and the threat the Trump administration posed to the environment and to scientific thought in general.
Nye will also voice himself in the upcoming animated feature Happy Halloween
Bill Nye