After a supporting role in Steven Soderbergh's 1999 neo-noir crime film The Limey, she was cast in a supporting role, Cleo Miller, in the 2001 black comedy Sugar & Spice and had a minor role in David Lynch's critically acclaimed Mulholland Drive, which opened at the 2001 Cannes Film Festival.
She starred in several unaired TV pilots, including the lead role in Lost in Oz, an original sequel to The Wizard of Oz, inspired by the Oz books of L. Frank Baum.
After the pilot was filmed, a significant amount of time passed before the decision was made to film a second episode.
However, by then George's contract had lapsed, and, as she had just moved to America, she didn't want to move back to Australia to shoot it.
Ultimately, a second episode was never shot and the show was never picked up.

She starred in the short-lived ABC drama-comedy Thieves, co-starring John Stamos.
She starred in the sixth season premiere of the WB series Charmed, had a minor role opposite Renée Zellweger and Ewan McGregor in the 2003 romantic comedy Down with Love and was originally cast as Susan Freeman in the American series Coupling based on the British series of the same name.
After "an audition from hell", George was cast and filmed the pilot, but the network (NBC) then fired the writers and replaced George and her fellow castmembers Breckin Meyer and Emily Rutherfurd with Rena Sofer, Colin Ferguson and Sonya Walger, respectively.
The series lasted only four episodes and show creator Steven Moffat blamed NBC's meddling as the reason for the show's failure, saying that they "fucked it up because they intervened endlessly."
George later commented that she "dodged a bullet" by being replaced before the show aired.

In 2003, she landed the role of Lauren Reed on the ABC television series Alias.
She had auditioned to play lead character Sydney Bristow, but lost out to Jennifer Garner.
When that happened, ABC cast her on Thieves instead.
It was originally planned that George would guest-star for several episodes but she was quickly upgraded to regular.
To explain her character's accent (George is Australian), the writers wrote that she was born in the United States but grew up in London.
George left the show at the end of the third season, saying that "I got offered a couple of films so I decided to kind've [sic] move on."

Her first starring role in a feature film was Kathy Lutz in the 2005 remake of the 1979 horror film, The Amityville Horror.
The film was not well received by critics, but was a major success at the worldwide box office, grossing over $108 million.
Despite unfavorable reviews, Film Threat praised George and her co-star Ryan Reynolds's performances, stating that they "make a striking couple.
Both young and extremely attractive" and that she "does an impeccable American accent, but otherwise she is unremarkable as Kathy Lutz.
Her physical beauty is sometimes distracting, but not enough to keep the audience awed by her acting."
That same year, she played Deanna Schine in the thriller Derailed, co-starring Clive Owen and Jennifer Aniston, playing the wife of a man embroiled in an affair.

In March 2006, it was announced that she had been cast in the NBC comedy-drama series Lipstick Jungle, based on the novel of the same name by Candace Bushnell.
George was to play Nico Reilly, the editor-in-chief of Bonfire Magazine.
However, the show underwent significant changes with George and other castmates being replaced and with executive producers DeAnn Heline and Eileen Heisler, writers Rand Ravich and Jill Gordon and director Nigel Cole all fired.
George had been personally cast by Bushnell, but left in early 2007 when she was offered the HBO series In Treatment.
Also in 2006, she travelled to Brazil to film the horror-thriller Turistas (released in the UK and Ireland as Paradise Lost) with Josh Duhamel and Olivia Wilde.
Shooting lasted three months on what was the first Hollywood film to be shot entirely on location in Brazil and George, who learned to speak Spanish and Portuguese for the role, said that the experience "made me a better actress, mo
After a supporting role in Steven Soderbergh's 1999 neo-noir crime film The Limey, she was cast in a supporting role, Cleo Miller, in the 2001 black comedy Sugar & Spice and had a minor role in David Lynch's critically acclaimed Mulholland Drive, which opened at the 2001 Cannes Film Festival. She starred in several unaired TV pilots, including the lead role in Lost in Oz, an original sequel to The Wizard of Oz, inspired by the Oz books of L. Frank Baum. After the pilot was filmed, a significant amount of time passed before the decision was made to film a second episode. However, by then George's contract had lapsed, and, as she had just moved to America, she didn't want to move back to Australia to shoot it. Ultimately, a second episode was never shot and the show was never picked up.
She starred in the short-lived ABC drama-comedy Thieves, co-starring John Stamos. She starred in the sixth season premiere of the WB series Charmed, had a minor role opposite Renée Zellweger and Ewan McGregor in the 2003 romantic comedy Down with Love and was originally cast as Susan Freeman in the American series Coupling based on the British series of the same name. After "an audition from hell", George was cast and filmed the pilot, but the network (NBC) then fired the writers and replaced George and her fellow castmembers Breckin Meyer and Emily Rutherfurd with Rena Sofer, Colin Ferguson and Sonya Walger, respectively. The series lasted only four episodes and show creator Steven Moffat blamed NBC's meddling as the reason for the show's failure, saying that they "fucked it up because they intervened endlessly." George later commented that she "dodged a bullet" by being replaced before the show aired.
In 2003, she landed the role of Lauren Reed on the ABC television series Alias. She had auditioned to play lead character Sydney Bristow, but lost out to Jennifer Garner. When that happened, ABC cast her on Thieves instead. It was originally planned that George would guest-star for several episodes but she was quickly upgraded to regular. To explain her character's accent (George is Australian), the writers wrote that she was born in the United States but grew up in London. George left the show at the end of the third season, saying that "I got offered a couple of films so I decided to kind've [sic] move on."
Her first starring role in a feature film was Kathy Lutz in the 2005 remake of the 1979 horror film, The Amityville Horror. The film was not well received by critics, but was a major success at the worldwide box office, grossing over $108 million. Despite unfavorable reviews, Film Threat praised George and her co-star Ryan Reynolds's performances, stating that they "make a striking couple. Both young and extremely attractive" and that she "does an impeccable American accent, but otherwise she is unremarkable as Kathy Lutz. Her physical beauty is sometimes distracting, but not enough to keep the audience awed by her acting." That same year, she played Deanna Schine in the thriller Derailed, co-starring Clive Owen and Jennifer Aniston, playing the wife of a man embroiled in an affair.
In March 2006, it was announced that she had been cast in the NBC comedy-drama series Lipstick Jungle, based on the novel of the same name by Candace Bushnell. George was to play Nico Reilly, the editor-in-chief of Bonfire Magazine. However, the show underwent significant changes with George and other castmates being replaced and with executive producers DeAnn Heline and Eileen Heisler, writers Rand Ravich and Jill Gordon and director Nigel Cole all fired. George had been personally cast by Bushnell, but left in early 2007 when she was offered the HBO series In Treatment. Also in 2006, she travelled to Brazil to film the horror-thriller Turistas (released in the UK and Ireland as Paradise Lost) with Josh Duhamel and Olivia Wilde. Shooting lasted three months on what was the first Hollywood film to be shot entirely on location in Brazil and George, who learned to speak Spanish and Portuguese for the role, said that the experience "made me a better actress, mo
Melissa George