Frederick Henry and his wife Amalia of Solms-Braunfels had nine children, being seven daughters and two sons.
Four of their children, including one son, died in childhood, leaving Frederick Henry with only a single son as heir.
Ultimately, after the death of Frederick Henry's only male-line grandson, the stadtholdership was to pass to a distant agnatic cousin, who was married to Frederick Henry's daughter Albertine Agnes.
Frederick Henry's children were:
William II, Prince of Orange (27 May 1626 – 6 November 1650)
Luise Henriette of Nassau (27 December 1627 – 18 June 1667)
Henriëtte Amalia of Nassau (26 October 1628 – December 1628)
Elisabeth of Nassau (4 August 1630)
Isabella Charlotte of Nassau (22 January/28 April 1632 – 17 May 1642)
Albertine Agnes of Nassau (9 April 1634 – 24 May 1696)
Henriette Catherine of Nassau (10 February 1637 – 3 November 1708)
Hendrik Lodewijk of Nassau (30 November 1639 – 19 December 1639)
Maria of Nassau (5 September 1642 – 17/20 March 1688)
Alexandra of Nassau (1644—1670)
Frederick Henry recognized one illegitimate child by Margaretha Catharina Bruyns:
Frederick Nassau, lord of Zuylestein (1624–1672)
Frederick Henry and his wife Amalia of Solms-Braunfels had nine children, being seven daughters and two sons. Four of their children, including one son, died in childhood, leaving Frederick Henry with only a single son as heir. Ultimately, after the death of Frederick Henry's only male-line grandson, the stadtholdership was to pass to a distant agnatic cousin, who was married to Frederick Henry's daughter Albertine Agnes. Frederick Henry's children were:
William II, Prince of Orange (27 May 1626 – 6 November 1650)
Luise Henriette of Nassau (27 December 1627 – 18 June 1667)
Henriëtte Amalia of Nassau (26 October 1628 – December 1628)
Elisabeth of Nassau (4 August 1630)
Isabella Charlotte of Nassau (22 January/28 April 1632 – 17 May 1642)
Albertine Agnes of Nassau (9 April 1634 – 24 May 1696)
Henriette Catherine of Nassau (10 February 1637 – 3 November 1708)
Hendrik Lodewijk of Nassau (30 November 1639 – 19 December 1639)
Maria of Nassau (5 September 1642 – 17/20 March 1688)
Alexandra of Nassau (1644—1670)
Frederick Henry recognized one illegitimate child by Margaretha Catharina Bruyns:
Frederick Nassau, lord of Zuylestein (1624–1672)
Frederick Henry, Prince of Orange