Cushman made her initial professional appearance at age eighteen on April 8, 1835 at Boston's Tremont Theatre.
She then went to New Orleans where she performed successfully for one season, after which she returned to New York City to act under contract with the Bowery Theatre.
She scored rave reviews in Albany, New York for her portrayal of Lady Macbeth.

By 1839, her younger sister Susan Webb Cushman became an actress, and at the age of 14 had married Nelson Merriman.
Her husband abandoned her when she was pregnant and Charlotte cared for her sister.
The two sisters became famous for playing Romeo and Juliet together, with Charlotte playing Romeo and Susan playing Juliet.

In 1843, Cushman became involved romantically with Rosalie Sully, daughter of artist Thomas Sully.
By 1844, the romance had ended.
She began traveling abroad, acting in theater, and Sully died shortly thereafter.
 She was also very close to the writer Anne Hampton Brewster around 1844 but social pressure from Brewster's brother meant that they had to part.
Brewster reminisced about their idyllic time together in letters in 1849.
She eventually left a portrait of Cushman by Thomas Sully as a bequest to the Library of Philadelphia.

In 1848, Cushman met journalist, writer and part-time actress Matilda Hays.
The two women became close friends, and after a short amount of time and some correspondence, they became involved in an affair.
For the next ten years the two would be together almost constantly.
They became known for dressing alike, and in Europe were publicly known as a couple.

In 1849, Cushman returned to the United States and by 1852 had decided to retire from the stage.
She took up residence with Hays in Rome, Italy.
They began living in an American expatriate community there, made up mostly of the many lesbian artists and sculptors of the time.
Cushman used her notoriety to promote the works of African American/Native American sculptor Edmonia Lewis, who had become a close friend and whose work Cushman greatly admired.

In 1854, Hays left Cushman for sculptor Harriet Hosmer, which launched a series of jealous interactions among the three women.
Hays eventually returned to live with Cushman, but the tensions between her and Cushman would never be repaired.
By late 1857, Cushman was secretly involved with sculptor Emma Stebbins.
One night while Cushman was writing a note, Hays walked in on her.
Suspecting that the note was to Stebbins, Hays demanded to see it.
Although Cushman maintained that the note was not to Stebbins, she refused to show it to Hays.
The altercation that followed was explosive.
Hays became enraged and began chasing Cushman around the house, pounding her with her fists at every opportunity.
The relationship ended immediately and Hays moved out.
She then sued Cushman, stating in her claim that she had sacrificed her own career to support Cushman's career and therefore was due a certain payment.
Cushman paid her an unknown sum and the two women parted company forever.

Emma Stebbins moved in with Cushman shortly after the break-up.
Cushman traveled to America for a short tour a couple of months later.
Although Cushman maintained that she was devoted to Stebbins, she became involved with another woman not long after her relationship with Stebbins began.
Cushman met an 18-year-old actress, Emma Crow, the daughter of Wayman Crow, and fell for her.
The two women began an affair, and Cushman often called her "my little lover".

Before her departure to Italy, Cushman offered a farewell performance at the Washington Theater in the title role of Hamlet.
The poster advertising her appearance describes her as "a lady universally acknowledged as the greatest living tragic actress".

When Cushman returned to Italy, Crow followed.
Not long after arriving in Italy, Crow attracted the attention of Cushman's nephew, Ned Cushman.
In April 1861, Ned Cushman and Emma Crow married.

She was friends with artists, writers and politicians; when she came to Washington, D.C. in the 1860s, she often stayed at the home of Secretary of State William Seward, with w
Cushman made her initial professional appearance at age eighteen on April 8, 1835 at Boston's Tremont Theatre. She then went to New Orleans where she performed successfully for one season, after which she returned to New York City to act under contract with the Bowery Theatre. She scored rave reviews in Albany, New York for her portrayal of Lady Macbeth.
By 1839, her younger sister Susan Webb Cushman became an actress, and at the age of 14 had married Nelson Merriman. Her husband abandoned her when she was pregnant and Charlotte cared for her sister. The two sisters became famous for playing Romeo and Juliet together, with Charlotte playing Romeo and Susan playing Juliet.
In 1843, Cushman became involved romantically with Rosalie Sully, daughter of artist Thomas Sully. By 1844, the romance had ended. She began traveling abroad, acting in theater, and Sully died shortly thereafter.  She was also very close to the writer Anne Hampton Brewster around 1844 but social pressure from Brewster's brother meant that they had to part. Brewster reminisced about their idyllic time together in letters in 1849. She eventually left a portrait of Cushman by Thomas Sully as a bequest to the Library of Philadelphia.
In 1848, Cushman met journalist, writer and part-time actress Matilda Hays. The two women became close friends, and after a short amount of time and some correspondence, they became involved in an affair. For the next ten years the two would be together almost constantly. They became known for dressing alike, and in Europe were publicly known as a couple.
In 1849, Cushman returned to the United States and by 1852 had decided to retire from the stage. She took up residence with Hays in Rome, Italy. They began living in an American expatriate community there, made up mostly of the many lesbian artists and sculptors of the time. Cushman used her notoriety to promote the works of African American/Native American sculptor Edmonia Lewis, who had become a close friend and whose work Cushman greatly admired.
In 1854, Hays left Cushman for sculptor Harriet Hosmer, which launched a series of jealous interactions among the three women. Hays eventually returned to live with Cushman, but the tensions between her and Cushman would never be repaired. By late 1857, Cushman was secretly involved with sculptor Emma Stebbins. One night while Cushman was writing a note, Hays walked in on her. Suspecting that the note was to Stebbins, Hays demanded to see it. Although Cushman maintained that the note was not to Stebbins, she refused to show it to Hays. The altercation that followed was explosive. Hays became enraged and began chasing Cushman around the house, pounding her with her fists at every opportunity. The relationship ended immediately and Hays moved out. She then sued Cushman, stating in her claim that she had sacrificed her own career to support Cushman's career and therefore was due a certain payment. Cushman paid her an unknown sum and the two women parted company forever.
Emma Stebbins moved in with Cushman shortly after the break-up. Cushman traveled to America for a short tour a couple of months later. Although Cushman maintained that she was devoted to Stebbins, she became involved with another woman not long after her relationship with Stebbins began. Cushman met an 18-year-old actress, Emma Crow, the daughter of Wayman Crow, and fell for her. The two women began an affair, and Cushman often called her "my little lover".
Before her departure to Italy, Cushman offered a farewell performance at the Washington Theater in the title role of Hamlet. The poster advertising her appearance describes her as "a lady universally acknowledged as the greatest living tragic actress".
When Cushman returned to Italy, Crow followed. Not long after arriving in Italy, Crow attracted the attention of Cushman's nephew, Ned Cushman. In April 1861, Ned Cushman and Emma Crow married.
She was friends with artists, writers and politicians; when she came to Washington, D.C. in the 1860s, she often stayed at the home of Secretary of State William Seward, with w
Charlotte Cushman