The regiment was deployed to the West Indies in January 1819 and landed in Jamaica in March 1819.
It was renamed the 50th (or Duke of Clarence's) Regiment of Foot, in honour of the future King William IV in 1827.
It then became the 50th (the Queen's Own) Regiment of Foot in honour of the King's wife, Queen Adelaide in 1831.
The regiment travelled to Australia in detachments as escorts to prisoners in 1834, with detachments then stationed at Sydney, Norfolk Island and Tasmania, before being relieved and transported to India in 1841.
It fought in the Gwalior Campaign in December 1843 and were prominent at the Battle of Mudki in December 1845, the Battle of Ferozeshah later that month and the Battle of Aliwal in January 1846 as well as the Battle of Sobraon in February 1846 during the First Anglo-Sikh War.
Lieutenant Colonel Thomas Ryan, who had commanded the regiment in the early battles of the campaign and then commanded the 2nd Brigade at Sobraon, died two months later from the wounds he had received in that battle.
The regiment arrived back in England in July 1848.

The regiment embarked for Malta in February 1854 from where it sailed to Varna in June 1854 for service in the Crimean War.
The regiment fought at the Battle of Alma in September 1854, the Battle of Inkerman in November 1854 and in the Siege of Sevastopol in winter 1854.
The regiment left the Crimean Peninsula in May 1856.

The regiment landed in Auckland in November 1863 for service in the New Zealand Wars.
It joined a field force which marched into the interior of the country as part of Lieutenant General Duncan Cameron's West Coast campaign and while encamped at Nukumaru near Whanganui came under sustained attack from Māori in January 1865 during the Second Taranaki War: a total of 11 private soldiers from the regiment and 23 Māori died in the engagement.
The regiment moved to Sydney in June 1867 and then left for England in March 1869.

As part of the Cardwell Reforms of the 1870s, where single-battalion regiments were linked together to share a single depot and recruiting district in the United Kingdom, the 50th was linked with the 97th (The Earl of Ulster's) Regiment of Foot, and assigned to district no.
46 at Maidstone Barracks in Kent.
On 1 July 1881 the Childers Reforms came into effect and the regiment amalgamated with the 97th (The Earl of Ulster's) Regiment of Foot to form the Queen's Own Royal West Kent Regiment.
The regiment was deployed to the West Indies in January 1819 and landed in Jamaica in March 1819. It was renamed the 50th (or Duke of Clarence's) Regiment of Foot, in honour of the future King William IV in 1827. It then became the 50th (the Queen's Own) Regiment of Foot in honour of the King's wife, Queen Adelaide in 1831. The regiment travelled to Australia in detachments as escorts to prisoners in 1834, with detachments then stationed at Sydney, Norfolk Island and Tasmania, before being relieved and transported to India in 1841. It fought in the Gwalior Campaign in December 1843 and were prominent at the Battle of Mudki in December 1845, the Battle of Ferozeshah later that month and the Battle of Aliwal in January 1846 as well as the Battle of Sobraon in February 1846 during the First Anglo-Sikh War. Lieutenant Colonel Thomas Ryan, who had commanded the regiment in the early battles of the campaign and then commanded the 2nd Brigade at Sobraon, died two months later from the wounds he had received in that battle. The regiment arrived back in England in July 1848.
The regiment embarked for Malta in February 1854 from where it sailed to Varna in June 1854 for service in the Crimean War. The regiment fought at the Battle of Alma in September 1854, the Battle of Inkerman in November 1854 and in the Siege of Sevastopol in winter 1854. The regiment left the Crimean Peninsula in May 1856.
The regiment landed in Auckland in November 1863 for service in the New Zealand Wars. It joined a field force which marched into the interior of the country as part of Lieutenant General Duncan Cameron's West Coast campaign and while encamped at Nukumaru near Whanganui came under sustained attack from Māori in January 1865 during the Second Taranaki War: a total of 11 private soldiers from the regiment and 23 Māori died in the engagement. The regiment moved to Sydney in June 1867 and then left for England in March 1869.
As part of the Cardwell Reforms of the 1870s, where single-battalion regiments were linked together to share a single depot and recruiting district in the United Kingdom, the 50th was linked with the 97th (The Earl of Ulster's) Regiment of Foot, and assigned to district no. 46 at Maidstone Barracks in Kent. On 1 July 1881 the Childers Reforms came into effect and the regiment amalgamated with the 97th (The Earl of Ulster's) Regiment of Foot to form the Queen's Own Royal West Kent Regiment.
50th (Queen's Own) Regiment of Foot