Aortic stenosis is most commonly caused by age-related progressive calcification (>50% of cases), with a mean age of 65 to 70 years.
Another major cause of aortic stenosis is the calcification of a congenital bicuspid aortic valve (30-40% of cases), typically presenting earlier (ages 40+ to 50+).

Acute rheumatic fever post-inflammatory is the cause of less than 10% of cases.
Rare causes of aortic stenosis include Fabry disease, systemic lupus erythematosus, Paget disease, high blood uric acid levels, and infection.
Aortic stenosis is most commonly caused by age-related progressive calcification (>50% of cases), with a mean age of 65 to 70 years. Another major cause of aortic stenosis is the calcification of a congenital bicuspid aortic valve (30-40% of cases), typically presenting earlier (ages 40+ to 50+).
Acute rheumatic fever post-inflammatory is the cause of less than 10% of cases. Rare causes of aortic stenosis include Fabry disease, systemic lupus erythematosus, Paget disease, high blood uric acid levels, and infection.
Aortic stenosis