Following the defeat of his armies, Francis sought peace with Charles.
The negotiations began in July 1529 in the border city of Cambrai; they were conducted primarily between Francis's mother Louise of Savoy for the French and her sister-in-law Margaret of Austria for her nephew the Emperor (leading to its being known as the Paix des Dames, Peace of the Ladies), Charles himself having sailed from Barcelona to Italy shortly before.
The final terms largely mirrored those of the Treaty of Madrid three years earlier; Francis surrendered his rights to Artois, Flanders, and Tournai, and was obliged to pay a ransom of two million golden écus before his sons were to be released.
Removed, however, were both the humiliating surrender of Burgundy itself and the various points dealing with Charles de Bourbon, who, having been killed two years prior, was no longer a candidate for leading an independent Kingdom of Provence.
The final Treaty of Cambrai, signed on 3 August, removed France from the war, leaving Venice, Florence, and the Pope alone against Charles.

Charles, having arrived in Genoa, proceeded to Bologna to meet with the Pope.
Clement absolved the participants of the sack of Rome and promised to crown Charles.
In return, he received Ravenna and Cervia; cities which the Republic of Venice was forced to surrender—along with her remaining possessions in Apulia—to Charles in exchange for being permitted to retain the holdings she had won at Marignano.
Finally, Francesco was permitted to return to Milan—Charles having abandoned his earlier plan to place Alessandro de' Medici on the throne, in part due to Venetian objections—for the sum of 900,000 scudi.
Following the defeat of his armies, Francis sought peace with Charles. The negotiations began in July 1529 in the border city of Cambrai; they were conducted primarily between Francis's mother Louise of Savoy for the French and her sister-in-law Margaret of Austria for her nephew the Emperor (leading to its being known as the Paix des Dames, Peace of the Ladies), Charles himself having sailed from Barcelona to Italy shortly before. The final terms largely mirrored those of the Treaty of Madrid three years earlier; Francis surrendered his rights to Artois, Flanders, and Tournai, and was obliged to pay a ransom of two million golden écus before his sons were to be released. Removed, however, were both the humiliating surrender of Burgundy itself and the various points dealing with Charles de Bourbon, who, having been killed two years prior, was no longer a candidate for leading an independent Kingdom of Provence. The final Treaty of Cambrai, signed on 3 August, removed France from the war, leaving Venice, Florence, and the Pope alone against Charles.
Charles, having arrived in Genoa, proceeded to Bologna to meet with the Pope. Clement absolved the participants of the sack of Rome and promised to crown Charles. In return, he received Ravenna and Cervia; cities which the Republic of Venice was forced to surrender—along with her remaining possessions in Apulia—to Charles in exchange for being permitted to retain the holdings she had won at Marignano. Finally, Francesco was permitted to return to Milan—Charles having abandoned his earlier plan to place Alessandro de' Medici on the throne, in part due to Venetian objections—for the sum of 900,000 scudi.
War of the League of Cognac