On November 20, Guzmán signed a minor league contract with the San Diego Padres.
He had his contract purchased by San Diego on June 16, 2011.
The San Diego Union-Tribune wrote that Guzmán line-drive hitting style was perfectly suited to the Padres' home at Petco Park, and he emerged as the best hitter on their 2011 team, hitting .312 with a .847 OPS in 247 at-bats.
 However, he was not a proficient fielder at either first base or left field.
Padres general manager Jed Hoyer projected Guzmán as a second option at first base (behind Yonder Alonso) in 2012, otherwise he was a possibility in left field.

In 2012, Guzmán made the majority of starts in left field in April and May while Carlos Quentin was rehabbing a sore knee, and he returned to the position in September when Quentin's knee again bothered him.
 Otherwise, he made occasional starts at first and in right field, and he made 50 appearances as a pinch hitter.
 In a total of 321 plate appearances over 120 games, Guzmán hit .247 with a .737 OPS and 9 home runs.

Guzmán made the Padres 25-man roster in 2013 as a reserve outfielder and first baseman.
 He made 25 starts in left field, allowing Carlos Quentin to rest his knees early and late in the season.
 He also made 33 starts at first base, many in late June and early July when Yonder Alonso was out with a hand injury.
 Overall in 2013, Guzmán appeared in 126 games, and had 288 at-bats, including 48 as a pinch hitter.
 He hit .226 with a .675 OPS and 9 home runs.
On November 20, Guzmán signed a minor league contract with the San Diego Padres. He had his contract purchased by San Diego on June 16, 2011. The San Diego Union-Tribune wrote that Guzmán line-drive hitting style was perfectly suited to the Padres' home at Petco Park, and he emerged as the best hitter on their 2011 team, hitting .312 with a .847 OPS in 247 at-bats.  However, he was not a proficient fielder at either first base or left field. Padres general manager Jed Hoyer projected Guzmán as a second option at first base (behind Yonder Alonso) in 2012, otherwise he was a possibility in left field.
In 2012, Guzmán made the majority of starts in left field in April and May while Carlos Quentin was rehabbing a sore knee, and he returned to the position in September when Quentin's knee again bothered him.  Otherwise, he made occasional starts at first and in right field, and he made 50 appearances as a pinch hitter.  In a total of 321 plate appearances over 120 games, Guzmán hit .247 with a .737 OPS and 9 home runs.
Guzmán made the Padres 25-man roster in 2013 as a reserve outfielder and first baseman.  He made 25 starts in left field, allowing Carlos Quentin to rest his knees early and late in the season.  He also made 33 starts at first base, many in late June and early July when Yonder Alonso was out with a hand injury.  Overall in 2013, Guzmán appeared in 126 games, and had 288 at-bats, including 48 as a pinch hitter.  He hit .226 with a .675 OPS and 9 home runs.
Jesús Guzmán (baseball)