The primary means of transportation in Northern Michigan is by automobile.
Northern Michigan is served by one Interstate, and a number of U.S. Highways and Michigan state trunklines.

 I-75 runs northwest–southeast through the region between the Flint/Tri-Cities area and Mackinac Bridge at Mackinaw City, which leads on to the Upper Peninsula.

 US 10 enters Michigan after it crosses Lake Michigan from Manitowoc to Ludington.
US 10 runs from Ludington through Baldwin and Reed City before it becomes a freeway west of US 127 near the junction with M-115.
US 10 bypasses Midland and terminates at I-75 in Bay City.

 US 23 runs northward for about 200 miles (320 km) along (or parallel with) the Lake Huron shoreline as the Sunrise Side Coastal Highway from the Flint/Tri-Cities area.

 US 31 mainly parallels the Lake Michigan shore from the Ludington area north to Mackinaw City; near Traverse City, the highway cuts the base of the Leelanau Peninsula.

 US 127 ends at Grayling, connecting Northern Michigan with points south
 US 131 is a primary north–south highway that is a freeway from Manton southwards; north of the freeway terminus, the highway is mostly two lanes, connecting Kalkaska, Mancelona, and ending at US 31 in Petoskey.

 M-18 runs between Midland County, through Prudenville and Roscommon to M-72 in Crawford County.

 M-22 follows the Lake Michigan shoreline from Traverse City to Manistee and is a scenic drive along the Leelanau Peninsula and the Sleeping Bear Dunes National Lakeshore.

 M-27 runs along the old route of US 27 between Indian River and Cheboygan.

 M-32 runs between East Jordan and Alpena.

 M-33 runs between Alger (northwest of Standish) and Cheboygan.

 M-37 runs from Battle Creek via Grand Rapids to Traverse City and the Old Mission Peninsula.

 M-42 is a short route between Manton and M-66 north of Lake City.

 M-55 is a 150-mile (240 km) transpeninsular highway at the southern edge of the region from Manistee to Tawas City.

 M-65 runs northward from Au Gres (just north of Standish) to Rogers City,.

 M-66 traverses almost the entire north–south distance of the Lower Peninsula ending at Charlevoix.

 M-68 is an east–west state highway that runs from Alanson to Rogers City; it passes through Indian River, Afton, Tower, and Onaway.

 M-72 crosses the Lower Peninsula from Empire via Traverse City to Harrisville.

 M-75 is a connector between US-131 and Boyne City, and, despite its proximity to the highway, is not related to I-75.

 M-88 traverses Antrim County from Eastport to Mancelona via a handful of small towns.

 M-93 is a short highway connecting Camp Grayling, Hartwick Pines, and the city of Grayling in Crawford County.

 M-109 serves as a scenic loop off M-22 in the Sleeping Bear Dunes.

 M-113 runs across southern Grand Traverse County connecting M-37, US-131, and the village of Kingsley.

 M-115 is a "diagonal highway", taking a generally northwest–southeast direction from Clare to Frankfort.

 M-119 spurs off US-31 near Petoskey through Harbor Springs and along the Lake Michigan Coast as the Tunnel of Trees.

 M-137 is a short highway running from US-31 to Interlochen Center for the Arts.
The highway has become famous among students.

 M-204 cuts across Leelanau County from Leland to Suttons Bay.

 M-212 is the shortest signed highway in the state, connecting Aloha State Park to M-33 south of Cheboygan.
The primary means of transportation in Northern Michigan is by automobile. Northern Michigan is served by one Interstate, and a number of U.S. Highways and Michigan state trunklines.
 I-75 runs northwest–southeast through the region between the Flint/Tri-Cities area and Mackinac Bridge at Mackinaw City, which leads on to the Upper Peninsula.
 US 10 enters Michigan after it crosses Lake Michigan from Manitowoc to Ludington. US 10 runs from Ludington through Baldwin and Reed City before it becomes a freeway west of US 127 near the junction with M-115. US 10 bypasses Midland and terminates at I-75 in Bay City.
 US 23 runs northward for about 200 miles (320 km) along (or parallel with) the Lake Huron shoreline as the Sunrise Side Coastal Highway from the Flint/Tri-Cities area.
 US 31 mainly parallels the Lake Michigan shore from the Ludington area north to Mackinaw City; near Traverse City, the highway cuts the base of the Leelanau Peninsula.
 US 127 ends at Grayling, connecting Northern Michigan with points south
 US 131 is a primary north–south highway that is a freeway from Manton southwards; north of the freeway terminus, the highway is mostly two lanes, connecting Kalkaska, Mancelona, and ending at US 31 in Petoskey.
 M-18 runs between Midland County, through Prudenville and Roscommon to M-72 in Crawford County.
 M-22 follows the Lake Michigan shoreline from Traverse City to Manistee and is a scenic drive along the Leelanau Peninsula and the Sleeping Bear Dunes National Lakeshore.
 M-27 runs along the old route of US 27 between Indian River and Cheboygan.
 M-32 runs between East Jordan and Alpena.
 M-33 runs between Alger (northwest of Standish) and Cheboygan.
 M-37 runs from Battle Creek via Grand Rapids to Traverse City and the Old Mission Peninsula.
 M-42 is a short route between Manton and M-66 north of Lake City.
 M-55 is a 150-mile (240 km) transpeninsular highway at the southern edge of the region from Manistee to Tawas City.
 M-65 runs northward from Au Gres (just north of Standish) to Rogers City,.
 M-66 traverses almost the entire north–south distance of the Lower Peninsula ending at Charlevoix.
 M-68 is an east–west state highway that runs from Alanson to Rogers City; it passes through Indian River, Afton, Tower, and Onaway.
 M-72 crosses the Lower Peninsula from Empire via Traverse City to Harrisville.
 M-75 is a connector between US-131 and Boyne City, and, despite its proximity to the highway, is not related to I-75.
 M-88 traverses Antrim County from Eastport to Mancelona via a handful of small towns.
 M-93 is a short highway connecting Camp Grayling, Hartwick Pines, and the city of Grayling in Crawford County.
 M-109 serves as a scenic loop off M-22 in the Sleeping Bear Dunes.
 M-113 runs across southern Grand Traverse County connecting M-37, US-131, and the village of Kingsley.
 M-115 is a "diagonal highway", taking a generally northwest–southeast direction from Clare to Frankfort.
 M-119 spurs off US-31 near Petoskey through Harbor Springs and along the Lake Michigan Coast as the Tunnel of Trees.
 M-137 is a short highway running from US-31 to Interlochen Center for the Arts. The highway has become famous among students.
 M-204 cuts across Leelanau County from Leland to Suttons Bay.
 M-212 is the shortest signed highway in the state, connecting Aloha State Park to M-33 south of Cheboygan.
Northern Michigan