The building was designed by the renowned architect Manuel Piqueras Cotolí (1885 – 1937).
Cotoli was born in Lucena, Córdoba but moved to Peru to study and became known for his buildings which blended indigenous and colonial architecture.
These buildings include the Escuela Nacional Superior Autónoma de Bellas Artes, Pizarro´s Tomb in the Cathedral of Lima, and the Archbishop's Palace.
The blending of architectural styles is easily visible from the outside of La Casa de la Ciencia, and many parts of the building share similarities with Cotoli’s Peruvian works.

A part of the building holds the Consulate General of Peru in Seville.

In July 2008 the Peruvian ambassador to Spain signed a 75-year renewal of the assignment by the City of Seville of the Pavilion of Peru to the Republic of Peru and to the CSIC.
The CSIC had undertaken to provide a 3,000 square metres (32,000 sq ft) exhibition space open to the public dedicated to the extension of science in Andalusia.
The building was designed by the renowned architect Manuel Piqueras Cotolí (1885 – 1937). Cotoli was born in Lucena, Córdoba but moved to Peru to study and became known for his buildings which blended indigenous and colonial architecture. These buildings include the Escuela Nacional Superior Autónoma de Bellas Artes, Pizarro´s Tomb in the Cathedral of Lima, and the Archbishop's Palace. The blending of architectural styles is easily visible from the outside of La Casa de la Ciencia, and many parts of the building share similarities with Cotoli’s Peruvian works.
A part of the building holds the Consulate General of Peru in Seville.
In July 2008 the Peruvian ambassador to Spain signed a 75-year renewal of the assignment by the City of Seville of the Pavilion of Peru to the Republic of Peru and to the CSIC. The CSIC had undertaken to provide a 3,000 square metres (32,000 sq ft) exhibition space open to the public dedicated to the extension of science in Andalusia.
La Casa de la Ciencia