Lord Cholmondeley married Lady Georgiana Charlotte Bertie, daughter of Peregrine Bertie, 3rd Duke of Ancaster and Kesteven, on 25 April 1791.
Through this marriage the ancient hereditary office of Lord Great Chamberlain came into the Cholmondeley family.

He inherited Houghton Hall in Norfolk from his great-uncle Horace Walpole in 1797 but preferred to live at Cholmondeley Castle in Cheshire, which had been rebuilt in 1801-04 to his design.

He was friends with the disreputable courtesans Gertrude Mahon, Grace Elliott and Kitty Frederick.
According to the betting book for Brooks's, a London gentlemen's club, Cholmondeley once wagered two guineas to Lord Derby, to receive 500 guineas upon having sexual intercourse with a woman "in a balloon one thousand yards from the Earth."
It is unknown whether the bet was ever finalised.

Lord Cholmondeley died at age 77 in April 1827, and he was succeeded in his lands, estates and titles by his eldest son George.
Lady Cholmondeley died in 1838.
Lord Cholmondeley married Lady Georgiana Charlotte Bertie, daughter of Peregrine Bertie, 3rd Duke of Ancaster and Kesteven, on 25 April 1791. Through this marriage the ancient hereditary office of Lord Great Chamberlain came into the Cholmondeley family.
He inherited Houghton Hall in Norfolk from his great-uncle Horace Walpole in 1797 but preferred to live at Cholmondeley Castle in Cheshire, which had been rebuilt in 1801-04 to his design.
He was friends with the disreputable courtesans Gertrude Mahon, Grace Elliott and Kitty Frederick. According to the betting book for Brooks's, a London gentlemen's club, Cholmondeley once wagered two guineas to Lord Derby, to receive 500 guineas upon having sexual intercourse with a woman "in a balloon one thousand yards from the Earth." It is unknown whether the bet was ever finalised.
Lord Cholmondeley died at age 77 in April 1827, and he was succeeded in his lands, estates and titles by his eldest son George. Lady Cholmondeley died in 1838.
George Cholmondeley, 1st Marquess of Cholmondeley