On 8 June 2010, Senderos signed a three-year deal with Fulham on a free transfer.
On 9 August, while training, Senderos tore his Achilles tendon, keeping him out for six months.
He underwent surgery and was expected to be out for 6 months.
He finally made his debut for Fulham on 30 April 2011 against Sunderland.
On 21 April 2012, he scored his first Premier League goal since joining Fulham as they defeated Wigan Athletic 2–1 at Craven Cottage.

On 1 March 2013, Senderos signed a one-year contract extension, keeping him at the West London club until June 2014.
On 21 October 2013, he scored a goal in a 4–1 win over Crystal Palace.

On 31 January 2014, Senderos joined Valencia from Fulham with just hours remaining before the transfer window was due to close.
He made his Valencia debut on 8 February 2014, playing 81 minutes in the 5–0 home win over Real Betis in a La Liga match, and scored his first goal (a header) on 13 March in the 3–0 away victory over Bulgarian champions Ludogorets Razgrad in the first leg of the round of 16 of the UEFA Europa League.
On 8 June 2010, Senderos signed a three-year deal with Fulham on a free transfer. On 9 August, while training, Senderos tore his Achilles tendon, keeping him out for six months. He underwent surgery and was expected to be out for 6 months. He finally made his debut for Fulham on 30 April 2011 against Sunderland. On 21 April 2012, he scored his first Premier League goal since joining Fulham as they defeated Wigan Athletic 2–1 at Craven Cottage.
On 1 March 2013, Senderos signed a one-year contract extension, keeping him at the West London club until June 2014. On 21 October 2013, he scored a goal in a 4–1 win over Crystal Palace.
On 31 January 2014, Senderos joined Valencia from Fulham with just hours remaining before the transfer window was due to close. He made his Valencia debut on 8 February 2014, playing 81 minutes in the 5–0 home win over Real Betis in a La Liga match, and scored his first goal (a header) on 13 March in the 3–0 away victory over Bulgarian champions Ludogorets Razgrad in the first leg of the round of 16 of the UEFA Europa League.
Philippe Senderos