On 12 January 2010, Carl Vinson departed Naval Station Norfolk for its new homeport of San Diego with squadrons VFA-81, VAW-125, VRC-40, and HS-15 embarked.

Just hours after the 2010 Haiti earthquake, Carl Vinson was redirected from the North Atlantic to Haiti to contribute to the Operation Unified Response relief effort.
On 15 January, the Carl Vinson arrived off the coast of Port-au-Prince (pictured) to provide humanitarian aid, with its trained personnel, emergency relief supplies, and 19 helicopters on deck.
On 16 January, the Bunker Hill arrived in Haiti to assist the Carl Vinson.
In addition to providing medical relief, Carl Vinson's desalination capacity provided fresh drinkable water to Haiti's population.
In total, the Carl Vinson delivered 1,095,442 lbs. (
496,884 kg) of food; 147,591 gallons (558,693 liters) of potable water; and more than 40,000 lbs. (
18,143 kg) of medical supplies.
The ship's medical team treated 60 patients.
 The Carl Vinson's embarked helicopters flew 1,299 sorties, conducted 1,152 medical evacuations, and delivered more than 2,900,000 lbs. (
1,315,418 kg) of cargo ashore.
On 1 February, the Carl Vinson, the cruiser Bunker Hill, and the oceanographic survey ship Henson ended their mission and departed Haiti although ten of Carl Vinson's helicopters remained to support the relief effort.

In March 2010, during her transit around South America, the carrier strike group participated in Southern Seas 2010 naval maneuvers with the Brazilian, Uruguayan, and Argentine navies.
The group also paid port visits to Rio de Janeiro, Brazil, and Callao, Peru.
  Carl Vinson arrived at its new homeport on 12 April 2010 following a three-month underway period.
On 12 January 2010, Carl Vinson departed Naval Station Norfolk for its new homeport of San Diego with squadrons VFA-81, VAW-125, VRC-40, and HS-15 embarked.
Just hours after the 2010 Haiti earthquake, Carl Vinson was redirected from the North Atlantic to Haiti to contribute to the Operation Unified Response relief effort. On 15 January, the Carl Vinson arrived off the coast of Port-au-Prince (pictured) to provide humanitarian aid, with its trained personnel, emergency relief supplies, and 19 helicopters on deck. On 16 January, the Bunker Hill arrived in Haiti to assist the Carl Vinson. In addition to providing medical relief, Carl Vinson's desalination capacity provided fresh drinkable water to Haiti's population. In total, the Carl Vinson delivered 1,095,442 lbs. (496,884 kg) of food; 147,591 gallons (558,693 liters) of potable water; and more than 40,000 lbs. (18,143 kg) of medical supplies. The ship's medical team treated 60 patients.  The Carl Vinson's embarked helicopters flew 1,299 sorties, conducted 1,152 medical evacuations, and delivered more than 2,900,000 lbs. (1,315,418 kg) of cargo ashore. On 1 February, the Carl Vinson, the cruiser Bunker Hill, and the oceanographic survey ship Henson ended their mission and departed Haiti although ten of Carl Vinson's helicopters remained to support the relief effort.
In March 2010, during her transit around South America, the carrier strike group participated in Southern Seas 2010 naval maneuvers with the Brazilian, Uruguayan, and Argentine navies. The group also paid port visits to Rio de Janeiro, Brazil, and Callao, Peru.   Carl Vinson arrived at its new homeport on 12 April 2010 following a three-month underway period.
Carrier Strike Group 1