Plasma Gelsolin is a 755 AA, 83 kDa plasma protein made up of six "gelsolin domains", each composed of a 5-6 strand β-sheet between one long and one short α-helix.

It exhibits a weak homology between domains S1 and S4, S2 and S5, and S3 and S6, and is identical to the cytoplasmic form of the protein except for the addition of a 24 AA N-terminal extension.
Additionally a 27 AA N-terminal signal peptide is cleaved prior to pGSN's secretion from the cell.
Both forms of the protein are encoded by highly conserved genes on chromosome 9 in humans, but are under the control of different promoters.

There is a single disulfide bond formed on the second domain of the plasma protein, there are no documented natural post-translational modifications, and the pI ≈ 6.
Plasma Gelsolin is a 755 AA, 83 kDa plasma protein made up of six "gelsolin domains", each composed of a 5-6 strand β-sheet between one long and one short α-helix.
It exhibits a weak homology between domains S1 and S4, S2 and S5, and S3 and S6, and is identical to the cytoplasmic form of the protein except for the addition of a 24 AA N-terminal extension. Additionally a 27 AA N-terminal signal peptide is cleaved prior to pGSN's secretion from the cell. Both forms of the protein are encoded by highly conserved genes on chromosome 9 in humans, but are under the control of different promoters.
There is a single disulfide bond formed on the second domain of the plasma protein, there are no documented natural post-translational modifications, and the pI ≈ 6.
Plasma gelsolin