On Thanksgiving, the Commodores reached the season's high point and beat the Carlisle Indians 4–0.
Just a week before the contest, Vanderbilt negotiated a game with Carlisle to fill an open date.
The Nashville Banner predicted it would be: "the greatest game the south ever saw."
The game started forty-five minutes late to accommodate the large crowd.

Vanderbilt won by a single, 17-yard Bob Blake field goal 4–0.
 In the first two minutes of play, the Indians drove the ball to Vanderbilt's 3-yard line, but the Commodores line held and they got no further.
Frank Mount Pleasant, one of the first regular spiral pass quarterbacks, attempted four field goals, but missed them all.

Atlanta Constitution sporting editor A. W. Lynn wrote: "The general surprises are numerous enough, but the largest particular one was the Commodore–Indian contest, when Vanderbilt took off the greatest honors ever falling to the lot of a southern football team in the hardest battle ever fought on a southern gridiron.
John Heisman wrote: "Manier bucked the Indians' line.
Costen handled the ball surely and well downed Mt. Pleasant in his tracks on most of Blake's punts...I am still convinced that outside Yale and Princeton, the Commodores would have an even break with any other team in the country."
Vanderbilt running back Honus Craig called this his hardest game, giving special praise to Albert Exendine as: "the fastest end I ever saw."

One source claims the Carlisle Indians failed to receive supplies on the trip to Nashville, including their receiving carboys emptied of water. "
The Indians had the poorest kind of accommodations at Nashville, and on account of the change of water every one of them became ill."

The starting lineup was: V. Blake (left end); Pritchard (left tackle); McLain (left guard); Stone (center); Chorn (right guard); E. Noel (right tackle); B. Blake (right end); Costen (quarterback); D. Blake (left halfback); Craig (right halfback); Manier (fullback).
On Thanksgiving, the Commodores reached the season's high point and beat the Carlisle Indians 4–0. Just a week before the contest, Vanderbilt negotiated a game with Carlisle to fill an open date. The Nashville Banner predicted it would be: "the greatest game the south ever saw." The game started forty-five minutes late to accommodate the large crowd.
Vanderbilt won by a single, 17-yard Bob Blake field goal 4–0.  In the first two minutes of play, the Indians drove the ball to Vanderbilt's 3-yard line, but the Commodores line held and they got no further.Frank Mount Pleasant, one of the first regular spiral pass quarterbacks, attempted four field goals, but missed them all.
Atlanta Constitution sporting editor A. W. Lynn wrote: "The general surprises are numerous enough, but the largest particular one was the Commodore–Indian contest, when Vanderbilt took off the greatest honors ever falling to the lot of a southern football team in the hardest battle ever fought on a southern gridiron. John Heisman wrote: "Manier bucked the Indians' line. Costen handled the ball surely and well downed Mt. Pleasant in his tracks on most of Blake's punts...I am still convinced that outside Yale and Princeton, the Commodores would have an even break with any other team in the country." Vanderbilt running back Honus Craig called this his hardest game, giving special praise to Albert Exendine as: "the fastest end I ever saw."
One source claims the Carlisle Indians failed to receive supplies on the trip to Nashville, including their receiving carboys emptied of water. "The Indians had the poorest kind of accommodations at Nashville, and on account of the change of water every one of them became ill."
The starting lineup was: V. Blake (left end); Pritchard (left tackle); McLain (left guard); Stone (center); Chorn (right guard); E. Noel (right tackle); B. Blake (right end); Costen (quarterback); D. Blake (left halfback); Craig (right halfback); Manier (fullback).
1906 Vanderbilt Commodores football team