The footprint of the cathedral is of a cruciform plan.
It features a large dome at the crossing of the transept and the nave.
The interior consists of eight bays plus the apse.
 The westernmost bay accommodates the vestibule.
Above this vestibule is a second level choir loft, accessible via a wooden stairway connected to the front wall.
A large pipe organ, said to have been played by Juan Morel Campos every Sunday for many years, is also on this second level loft.
The cathedral measures 42.2m long by 19.4m wide.

Arcades of semi-circular arches divide the nave from the aisles.
On the south side of the cathedral, a large chapel, built in 1911, extends three bays parallel to the aisle.
This chapel provides a more intimate place of worship than the main church or its aisles.
The nave has a cross vaulted ceiling with clerestory windows above the arcades.
The cathedral's main neoclassical altar of translucent alabaster is a modern replacement for the original wooden gothic altar, now located in the southern side chapel.
The main altar, built in Burgos, Spain, was donated by the local Ferre family.
Except for the side chapel where terrazzo is used, the cathedral's floor is of gray and white marble design.
The footprint of the cathedral is of a cruciform plan. It features a large dome at the crossing of the transept and the nave. The interior consists of eight bays plus the apse.  The westernmost bay accommodates the vestibule. Above this vestibule is a second level choir loft, accessible via a wooden stairway connected to the front wall. A large pipe organ, said to have been played by Juan Morel Campos every Sunday for many years, is also on this second level loft. The cathedral measures 42.2m long by 19.4m wide.
Arcades of semi-circular arches divide the nave from the aisles. On the south side of the cathedral, a large chapel, built in 1911, extends three bays parallel to the aisle. This chapel provides a more intimate place of worship than the main church or its aisles. The nave has a cross vaulted ceiling with clerestory windows above the arcades. The cathedral's main neoclassical altar of translucent alabaster is a modern replacement for the original wooden gothic altar, now located in the southern side chapel. The main altar, built in Burgos, Spain, was donated by the local Ferre family. Except for the side chapel where terrazzo is used, the cathedral's floor is of gray and white marble design.
Catedral de Nuestra Señora de Guadalupe