2006: the front fascia, side molding, headlamps and tail lights were restyled.
Blue-backlit electroluminescent Optitron gauges were added to LE, XLE, and Limited trims.
The "XLE" prefix in "XLE Limited" was removed, and new exclusive equipment for this trim included an optional memory function for the driver's power seat and side-view mirrors (also available on XLE as an option) and power-folding exterior side-view mirrors with integrated in-glass LED turn-signal repeaters.
Other options included Bluetooth and a power-folding third-row seat.
Front row side torso airbags and side curtain airbags for all three rows became standard equipment on all models.
The optional rear seat audio system was discontinued.
Horsepower and torque ratings were changed to meet SAE's new standard to 215 hp (160 kW) and 222 lb·ft (from 230 hp (172 kW) and 242 lb⋅ft (328 N⋅m), Toyota also now rates engines on 87 octane).

2007:  a new ULEV-II certified 3.5-liter 2GR-FE V6 engine rated at 266 hp (198 kW) with a rated fuel economy of 17/23 MPG for front-wheel-drive models and 16/21 MPG for AWD models replaced the 3.3-liter V6.
This engine had a lower-maintenance timing chain as opposed to the timing belt of previous Sienna engines.
 The tire pressure monitor was upgraded, and a new seven-spoke alloy wheel design was made exclusive to the Limited and AWD models.

2008: Vehicle Stability Control became standard in all trims.

2009: the Sienna remained largely unchanged, except for a revision in pricing to become more competitive through several available comprehensively equipped "extra-value package" offerings.
In Canada, base prices were lowered by up to $1,500.

2010: the second generation Sienna was unchanged in its final model year.
2006: the front fascia, side molding, headlamps and tail lights were restyled. Blue-backlit electroluminescent Optitron gauges were added to LE, XLE, and Limited trims. The "XLE" prefix in "XLE Limited" was removed, and new exclusive equipment for this trim included an optional memory function for the driver's power seat and side-view mirrors (also available on XLE as an option) and power-folding exterior side-view mirrors with integrated in-glass LED turn-signal repeaters. Other options included Bluetooth and a power-folding third-row seat. Front row side torso airbags and side curtain airbags for all three rows became standard equipment on all models. The optional rear seat audio system was discontinued. Horsepower and torque ratings were changed to meet SAE's new standard to 215 hp (160 kW) and 222 lb·ft (from 230 hp (172 kW) and 242 lb⋅ft (328 N⋅m), Toyota also now rates engines on 87 octane).
2007:  a new ULEV-II certified 3.5-liter 2GR-FE V6 engine rated at 266 hp (198 kW) with a rated fuel economy of 17/23 MPG for front-wheel-drive models and 16/21 MPG for AWD models replaced the 3.3-liter V6. This engine had a lower-maintenance timing chain as opposed to the timing belt of previous Sienna engines.  The tire pressure monitor was upgraded, and a new seven-spoke alloy wheel design was made exclusive to the Limited and AWD models.
2008: Vehicle Stability Control became standard in all trims.
2009: the Sienna remained largely unchanged, except for a revision in pricing to become more competitive through several available comprehensively equipped "extra-value package" offerings. In Canada, base prices were lowered by up to $1,500.
2010: the second generation Sienna was unchanged in its final model year.
Toyota Sienna