On February 16, 2010, Ono revived an early Plastic Ono Band lineup with Eric Clapton and special guests that included Paul Simon and Bette Midler.
On April 1 of that year, she was named the first "Global Autism Ambassador" by the Autism Speaks organization.
She had created an artwork the year before for autism awareness and allowed it to be auctioned off in 67 parts to benefit the organization.
Ono appeared with Ringo Starr on July 7 at New York's Radio City Music Hall in celebration of Starr's 70th birthday, performing With a Little Help from My Friends and "Give Peace a Chance".
On September 16, she and Sean attended the opening of Julian Lennon's photo exhibition at the Morrison Hotel in New York City, appearing for the first time photos with Cynthia and Julian.
She also promoted his work on her website.
On October 2, Ono and the Plastic Ono Band performed at the Orpheum Theatre in Los Angeles, with special guest Lady Gaga, whom she deeply admires.

On February 18, 2011 (her 78th birthday), Ono took out a full-page advert in the UK free newspaper Metro for "Imagine Peace 2011".
It took the form of an open letter, inviting people to think of, and wish for, peace.
With son Sean, she held a benefit concert to aid in the relief efforts for earthquake and tsunami-ravaged Japan on March 27 in New York City.
The effort raised a total of $33,000.
In July 2011, she visited Japan to support earthquake and tsunami victims and tourism to the country.
During her visit, Ono gave a lecture and performance entitled "The Road of Hope" at Tokyo's Mori Art Museum, during which she painted a large calligraphy piece entitled "Dream" to help raise funds for construction of the Rainbow House, an institution for the orphans of the Great East Japan earthquake.
She also collected the 8th Hiroshima Art Prize for her contributions to art and for peace, that she was awarded the year prior.

In January 2012, a Ralphi Rosario mix of her 1995 song Talking to the Universe became her seventh consecutive No.
1 hit on the Billboard Hot Dance Club Songs chart.
In March of the same year, she was awarded the 20,000-euro ($26,400) Oskar Kokoschka Prize in Austria.
From June 19 to September 9, her work To the Light was exhibited at the Serpentine Gallery in London.
It was held in conjunction with the London 2012 Festival, a 12-week UK-wide celebration featuring internationally renowned artists from Midsummer's Day (June 21) to the final day of the Paralympic Games on September 9.

On June 29, 2012, Ono received a lifetime achievement award at the Dublin Biennial.
During this (her second) trip to Ireland (the first was with John before they married), she visited the crypt of Irish leader Daniel O'Connell at Glasnevin Cemetery and Dún Laoghaire, from where Irish departed for England to escape the famine.
In February 2013, Ono accepted the Rainer Hildebrandt Medal at Berlin's Checkpoint Charlie Museum, awarded to her and Lennon for their lifetime of work for peace and human rights.

The next month, she tweeted an anti-gun message with the Season of Glass image of Lennon's bloodied glasses on what would have been her and Lennon's 44th anniversary, noting that guns have killed more than 1 million people since Lennon's death in 1980.

She was also given a Congressional citation from the Philippines for her monetary aid to the victims of typhoon Pablo.
She also donated to disaster relief efforts after typhoon Ondoy in 2009, and she assists Filipino schoolchildren.

In June 2013, she curated the Meltdown festival in London, where she played two concerts, one with the Plastic Ono Band, and the second on backing vocals during Siouxsie Sioux's rendition of "Walking on Thin Ice" at the Double Fantasy show.
In July, OR Books published Ono's sequel to 1964's Grapefruit, another book of instruction-based 'action poems' this time entitled, Acorn.

In 2009 she became an honorary patron to Alder Hey Charity.

On February 26, 2016, Ono was hospitalized after suffering what was rumored to be a possible stroke.
It was later announced that she was experiencing extreme symptoms of the flu
On February 16, 2010, Ono revived an early Plastic Ono Band lineup with Eric Clapton and special guests that included Paul Simon and Bette Midler. On April 1 of that year, she was named the first "Global Autism Ambassador" by the Autism Speaks organization. She had created an artwork the year before for autism awareness and allowed it to be auctioned off in 67 parts to benefit the organization. Ono appeared with Ringo Starr on July 7 at New York's Radio City Music Hall in celebration of Starr's 70th birthday, performing With a Little Help from My Friends and "Give Peace a Chance". On September 16, she and Sean attended the opening of Julian Lennon's photo exhibition at the Morrison Hotel in New York City, appearing for the first time photos with Cynthia and Julian. She also promoted his work on her website. On October 2, Ono and the Plastic Ono Band performed at the Orpheum Theatre in Los Angeles, with special guest Lady Gaga, whom she deeply admires.
On February 18, 2011 (her 78th birthday), Ono took out a full-page advert in the UK free newspaper Metro for "Imagine Peace 2011". It took the form of an open letter, inviting people to think of, and wish for, peace. With son Sean, she held a benefit concert to aid in the relief efforts for earthquake and tsunami-ravaged Japan on March 27 in New York City. The effort raised a total of $33,000. In July 2011, she visited Japan to support earthquake and tsunami victims and tourism to the country. During her visit, Ono gave a lecture and performance entitled "The Road of Hope" at Tokyo's Mori Art Museum, during which she painted a large calligraphy piece entitled "Dream" to help raise funds for construction of the Rainbow House, an institution for the orphans of the Great East Japan earthquake. She also collected the 8th Hiroshima Art Prize for her contributions to art and for peace, that she was awarded the year prior.
In January 2012, a Ralphi Rosario mix of her 1995 song Talking to the Universe became her seventh consecutive No. 1 hit on the Billboard Hot Dance Club Songs chart. In March of the same year, she was awarded the 20,000-euro ($26,400) Oskar Kokoschka Prize in Austria. From June 19 to September 9, her work To the Light was exhibited at the Serpentine Gallery in London. It was held in conjunction with the London 2012 Festival, a 12-week UK-wide celebration featuring internationally renowned artists from Midsummer's Day (June 21) to the final day of the Paralympic Games on September 9.
On June 29, 2012, Ono received a lifetime achievement award at the Dublin Biennial. During this (her second) trip to Ireland (the first was with John before they married), she visited the crypt of Irish leader Daniel O'Connell at Glasnevin Cemetery and Dún Laoghaire, from where Irish departed for England to escape the famine. In February 2013, Ono accepted the Rainer Hildebrandt Medal at Berlin's Checkpoint Charlie Museum, awarded to her and Lennon for their lifetime of work for peace and human rights.
The next month, she tweeted an anti-gun message with the Season of Glass image of Lennon's bloodied glasses on what would have been her and Lennon's 44th anniversary, noting that guns have killed more than 1 million people since Lennon's death in 1980.
She was also given a Congressional citation from the Philippines for her monetary aid to the victims of typhoon Pablo. She also donated to disaster relief efforts after typhoon Ondoy in 2009, and she assists Filipino schoolchildren.
In June 2013, she curated the Meltdown festival in London, where she played two concerts, one with the Plastic Ono Band, and the second on backing vocals during Siouxsie Sioux's rendition of "Walking on Thin Ice" at the Double Fantasy show. In July, OR Books published Ono's sequel to 1964's Grapefruit, another book of instruction-based 'action poems' this time entitled, Acorn.
In 2009 she became an honorary patron to Alder Hey Charity.
On February 26, 2016, Ono was hospitalized after suffering what was rumored to be a possible stroke. It was later announced that she was experiencing extreme symptoms of the flu
Yoko Ono