Andy Andrews, motivational speaker and self-help author
Artis Gilmore, former NBA star, member of Basketball Hall Of Fame
Bill Baxley, former Alabama Attorney General and Lieutenant Governor, born and raised in Dothan
Brad Baxter, former NFL running back
Tony Bowick, former NFL and Arena Football League player
Larry Brackins, professional football wide receiver
Johnny Mack Brown, born and raised in Dothan, Hollywood film star, and All-American, All-Southern college football player at the University of Alabama.

Buddy Buie, songwriter, producer, and publisher
Matt Cain, starting pitcher for the San Francisco Giants, born in Dothan
Elaine Cheris, fencer who competed in the 1988 and 1996 Summer Olympics
Kelsey Barnard Clark, chef, winner of season 16 of Top Chef
Mike Clark, former professional football defensive end
W. M. Cooper, who published a revision of B. F. White's popular song book The Sacred Harp in 1902, a collection of shape note hymns, important to religious revivals in the South
Jimmy Cross, radio producer and singer
Ashley Davis, Miss Alabama 2010
Lawrence Dawsey, former NFL wide receiver
Charles Bernard Day, federal judge
Frank Dempsey, former NFL player
Donna D'Errico, actress and model
Gardner Dickinson, seven-time PGA Tour champion golfer, born in Dothan
William Gray Espy, actor (the original Snapper Foster of The Young and the Restless), born in Dothan
Terry Everett, former member of the U.S. House of Representatives
Jim Farmer, former professional basketball player
Richmond Flowers, Sr.,
former Attorney General of Alabama and opponent of segregation, born and raised in Dothan
Richmond Flowers, former professional football player
Artis Gilmore, Jacksonville University center and later MVP of the American Basketball Association, attended middle and high school in Dothan
Bobby Goldsboro, singer noted for his 1968 Top 40 No.
1 hit "Honey", grew up in Dothan and graduated from Dothan High School
Thom Goolsby, former member of the North Carolina State Senate
Ken Grimwood, fantasy fiction author
Gabe Gross, a former quarterback and baseball All-American for Auburn University, former pro baseball player
Clay Holmes, current starting pitcher for the Pittsburgh Pirates; graduated from Slocomb High School
Kevin Jackson, former professional football safety
Robert Reynolds "Bob" Jones, Sr.,
evangelist and founder of Bob Jones University, reared in the Brannon Stand community west of Dothan, 1884–1899
David Kelton, former Major League Baseball player for the Chicago Cubs
Dale Kennington, contemporary artist working in the style of New American Realism, lived in Dothan, 1935-2017
Eddie Kirkland, electric blues guitarist and songwriter
Burton Lawless, former offensive lineman in the National Football League
Mickey McGowan, former professional baseball pitcher
Jim Parkman, criminal defense lawyer
Eulace Peacock, track and field athlete
Ricky Polston, Chief Justice of the Florida Supreme Court, 2012–2014
Izell Reese, former NFL defensive back
Larry Roberts, former NFL defensive end
Clint Robinson, Major League Baseball first baseman
Robert Edwin Russ, founder of Ruston, Louisiana, lived near Dothan in his early years
Patti Rutland, dance choreographer
Steadman S. Shealy, former football player and attorney
Haywood Sullivan, former Major League Baseball player
Jamie Thomas, creator of two skateboard companies and a shoe company, grew up in Dothan
Mark Walker, congressman from North Carolina
P. J. Walters, Major League Baseball pitcher
Heather Whitestone, former Miss America, born and raised in Dothan
Charles H. Wright, physician and founder of the Charles H. Wright Museum of African American History
Andy Andrews, motivational speaker and self-help author
Artis Gilmore, former NBA star, member of Basketball Hall Of Fame
Bill Baxley, former Alabama Attorney General and Lieutenant Governor, born and raised in Dothan
Brad Baxter, former NFL running back
Tony Bowick, former NFL and Arena Football League player
Larry Brackins, professional football wide receiver
Johnny Mack Brown, born and raised in Dothan, Hollywood film star, and All-American, All-Southern college football player at the University of Alabama.
Buddy Buie, songwriter, producer, and publisher
Matt Cain, starting pitcher for the San Francisco Giants, born in Dothan
Elaine Cheris, fencer who competed in the 1988 and 1996 Summer Olympics
Kelsey Barnard Clark, chef, winner of season 16 of Top Chef
Mike Clark, former professional football defensive end
W. M. Cooper, who published a revision of B. F. White's popular song book The Sacred Harp in 1902, a collection of shape note hymns, important to religious revivals in the South
Jimmy Cross, radio producer and singer
Ashley Davis, Miss Alabama 2010
Lawrence Dawsey, former NFL wide receiver
Charles Bernard Day, federal judge
Frank Dempsey, former NFL player
Donna D'Errico, actress and model
Gardner Dickinson, seven-time PGA Tour champion golfer, born in Dothan
William Gray Espy, actor (the original Snapper Foster of The Young and the Restless), born in Dothan
Terry Everett, former member of the U.S. House of Representatives
Jim Farmer, former professional basketball player
Richmond Flowers, Sr., former Attorney General of Alabama and opponent of segregation, born and raised in Dothan
Richmond Flowers, former professional football player
Artis Gilmore, Jacksonville University center and later MVP of the American Basketball Association, attended middle and high school in Dothan
Bobby Goldsboro, singer noted for his 1968 Top 40 No. 1 hit "Honey", grew up in Dothan and graduated from Dothan High School
Thom Goolsby, former member of the North Carolina State Senate
Ken Grimwood, fantasy fiction author
Gabe Gross, a former quarterback and baseball All-American for Auburn University, former pro baseball player
Clay Holmes, current starting pitcher for the Pittsburgh Pirates; graduated from Slocomb High School
Kevin Jackson, former professional football safety
Robert Reynolds "Bob" Jones, Sr., evangelist and founder of Bob Jones University, reared in the Brannon Stand community west of Dothan, 1884–1899
David Kelton, former Major League Baseball player for the Chicago Cubs
Dale Kennington, contemporary artist working in the style of New American Realism, lived in Dothan, 1935-2017
Eddie Kirkland, electric blues guitarist and songwriter
Burton Lawless, former offensive lineman in the National Football League
Mickey McGowan, former professional baseball pitcher
Jim Parkman, criminal defense lawyer
Eulace Peacock, track and field athlete
Ricky Polston, Chief Justice of the Florida Supreme Court, 2012–2014
Izell Reese, former NFL defensive back
Larry Roberts, former NFL defensive end
Clint Robinson, Major League Baseball first baseman
Robert Edwin Russ, founder of Ruston, Louisiana, lived near Dothan in his early years
Patti Rutland, dance choreographer
Steadman S. Shealy, former football player and attorney
Haywood Sullivan, former Major League Baseball player
Jamie Thomas, creator of two skateboard companies and a shoe company, grew up in Dothan
Mark Walker, congressman from North Carolina
P. J. Walters, Major League Baseball pitcher
Heather Whitestone, former Miss America, born and raised in Dothan
Charles H. Wright, physician and founder of the Charles H. Wright Museum of African American History
Dothan, Alabama