The station's busiest route is the Empire Service, with seven round trips to New York City, five of which originate and terminate here.
It is the descendant of the New York Central's express trains running along the eastern leg of the famed "Water Level Route" to Chicago.

With the exception of the Boston branch of the Lake Shore Limited, all trains have southbound service to Penn Station in New York City.

Adirondack to Montreal
Empire Service: all trains to New York (via Hudson, Rhinecliff, Poughkeepsie, Croton-on-Hudson, Yonkers); most northbound trains terminate here; two trains per day continue to Buffalo and Niagara Falls.

Ethan Allen Express to Rutland, Vermont
Lake Shore Limited to Syracuse, Rochester, Buffalo, Cleveland, Toledo, and Chicago
New York Branch (Train 48/49): Poughkeepsie, Croton-on-Hudson, New York (Penn Station)
Boston Branch (Train 448/449): Pittsfield, Springfield, Worcester, Framingham, Boston (Back Bay), Boston (South Station)
Maple Leaf to Toronto
Southbound, most non-Empire Service trains swap out a diesel GE P42DC locomotive for a diesel-electric P32AC-DM, since diesel locomotives have long been barred from Penn Station.
The P42DC is readied for a train coming northbound from New York City.
The station's busiest route is the Empire Service, with seven round trips to New York City, five of which originate and terminate here. It is the descendant of the New York Central's express trains running along the eastern leg of the famed "Water Level Route" to Chicago. 
With the exception of the Boston branch of the Lake Shore Limited, all trains have southbound service to Penn Station in New York City.
Adirondack to Montreal
Empire Service: all trains to New York (via Hudson, Rhinecliff, Poughkeepsie, Croton-on-Hudson, Yonkers); most northbound trains terminate here; two trains per day continue to Buffalo and Niagara Falls.
Ethan Allen Express to Rutland, Vermont
Lake Shore Limited to Syracuse, Rochester, Buffalo, Cleveland, Toledo, and Chicago
New York Branch (Train 48/49): Poughkeepsie, Croton-on-Hudson, New York (Penn Station)
Boston Branch (Train 448/449): Pittsfield, Springfield, Worcester, Framingham, Boston (Back Bay), Boston (South Station)
Maple Leaf to Toronto
Southbound, most non-Empire Service trains swap out a diesel GE P42DC locomotive for a diesel-electric P32AC-DM, since diesel locomotives have long been barred from Penn Station. The P42DC is readied for a train coming northbound from New York City.
Albany–Rensselaer station