Brandt was tried along with twenty-two others at the Palace of Justice in Nuremberg, Germany.
The trial was officially titled United States of America v. Karl Brandt et al.,
but is more commonly referred to as the "Doctors' Trial"; it began on 9 December 1946.
He was charged with four counts:
Conspiracy to commit war crimes and crimes against humanity as described in counts 2 and 3;
War crimes: performing medical experiments, without the subjects' consent, on prisoners of war and civilians of occupied countries, in the course of which experiments the defendants committed murders, brutalities, cruelties, tortures, atrocities, and other inhuman acts.
 Also planning and performing the mass murder of prisoners of war and civilians of occupied countries, stigmatized as aged, insane, incurably ill, deformed, and so on, by gas, lethal injections, and diverse other means in nursing homes, hospitals, and asylums during the Euthanasia Program and participating in the mass murder of concentration camp inmates;
Crimes against humanity: committing crimes described under count 2 also on German nationals;
Membership in a criminal organization, the SS.
The charges against him included special responsibility for, and participation in, Freezing, Malaria, LOST Gas, Sulfanilamide, Bone, Muscle and Nerve Regeneration and Bone Transplantation, Sea-Water, Epidemic Jaundice, Sterilization, and Typhus Experiments.

After a defence led by Robert Servatius, on 19 August 1947, Brandt was found guilty on counts 2-4 of the indictment.
With six others, he was sentenced to death by hanging, and all were executed at Landsberg Prison on 2 June 1948.
Nine other defendants received prison terms of between fifteen years and life, while a further seven were found not guilty.

While on the gallows, Brandt remarked: "It is no shame to stand upon the scaffold.
This is nothing but political revenge.
I have served my Fatherland as others before me."
He refused to end his speech, a hood was placed over his head while he continued to talk and he was hanged.
Brandt was tried along with twenty-two others at the Palace of Justice in Nuremberg, Germany. The trial was officially titled United States of America v. Karl Brandt et al., but is more commonly referred to as the "Doctors' Trial"; it began on 9 December 1946. He was charged with four counts:
Conspiracy to commit war crimes and crimes against humanity as described in counts 2 and 3;
War crimes: performing medical experiments, without the subjects' consent, on prisoners of war and civilians of occupied countries, in the course of which experiments the defendants committed murders, brutalities, cruelties, tortures, atrocities, and other inhuman acts.  Also planning and performing the mass murder of prisoners of war and civilians of occupied countries, stigmatized as aged, insane, incurably ill, deformed, and so on, by gas, lethal injections, and diverse other means in nursing homes, hospitals, and asylums during the Euthanasia Program and participating in the mass murder of concentration camp inmates;
Crimes against humanity: committing crimes described under count 2 also on German nationals;
Membership in a criminal organization, the SS. The charges against him included special responsibility for, and participation in, Freezing, Malaria, LOST Gas, Sulfanilamide, Bone, Muscle and Nerve Regeneration and Bone Transplantation, Sea-Water, Epidemic Jaundice, Sterilization, and Typhus Experiments.
After a defence led by Robert Servatius, on 19 August 1947, Brandt was found guilty on counts 2-4 of the indictment. With six others, he was sentenced to death by hanging, and all were executed at Landsberg Prison on 2 June 1948. Nine other defendants received prison terms of between fifteen years and life, while a further seven were found not guilty.
While on the gallows, Brandt remarked: "It is no shame to stand upon the scaffold. This is nothing but political revenge. I have served my Fatherland as others before me." He refused to end his speech, a hood was placed over his head while he continued to talk and he was hanged.
Karl Brandt