In 1957, the first letter of all the east-coast-based VX squadrons, including VX-6, was changed from X to J. In January 1958, a VX-6 UC-1 Otter made the first wheels-on-dirt landing in Antarctica at Marble Point.
On 1 October 1959, RADM David M. Tyree (Commander, U.S. Naval Support Force Antarctica from 14 April 1959–26 November 1962) arrived at Naval Air Facility McMurdo Station from Christchurch aboard an R5D Skymaster piloted by LCDR J. A. Henning of VX-6.
This first flight of the season marked the operational implementation of Operation Deep Freeze V.
On 9–10 April 1961, the first midwinter medical evacuation flight was conducted to rescue Leonid Kuperov, a seriously ill Soviet scientist, from Byrd Station.
Two VX-6 C-130BL Hercules from Quonset Point flew from to Christchurch.
One (piloted by CDR Lloyd E. Newcomer) then flew on to Byrd Station to pick up Kuperov, while the other stood by in Christchurch.
The total distance flown during this rescue mission was just under 13000 miles.

On 22 February 1963, an LC-130F Hercules of VX-6 made the longest flight in Antarctic history, covering territory never before seen by man.
The plane (piloted by CDR William H. Everett and carrying RADM James R. Reedy (Commander, U.S. Naval Support Force Antarctica from November 1962–April 1965) among its passengers, made the 3,470-mile (5,580 km) flight from McMurdo Station, beyond the South Pole to the Shackleton Range and then southeastward to the pole of inaccessibility before returning to McMurdo Station; the duration of this journey was 10 hours and 40 minutes.
Also in February 1963, VX-6 completed the first delivery of bulk fuel by a Lockheed LC-130 Hercules.

On 26 June 1964, an LC-130F Hercules, commanded by LT Robert V. Mayer of VX-6, completed a round-trip flight from Christchurch to Antarctica in an emergency evacuation of petty officer B. L. McMullen, critically injured in a fall.
As in the earlier medical evacuation of 1961, two planes, with teams of medical specialists on board, flew from NAS Quonset Point to Christchurch where one plane stood by while the other undertook the hazardous flight.
On 30 September 1964, three LC-130 Hercules aircraft of VX-6 took off from Melbourne, Christchurch and Punta Arenas, respectively.
The three aircraft flew to Antarctica, landing on Williams Field, 7 miles (11 km) from McMurdo Station.
The flight from Melbourne, the first in history from Australia to Antarctica, passed over the South Pole to drop a 50-pound sack of mail to the wintering-over party, then landed at Byrd Station before proceeding to McMurdo Station.
The arrival of RADM Reedy on this flight marked the official opening of Operation Deep Freeze 1965.
Also in 1964, VX-6 conducted the first flight from Cape Town, South Africa to McMurdo Station, the first flight of a U.S. aircraft to the Soviet Vostok Station, and the first successful demonstration of trimetrogon aerial photography, used extensively to map Antarctica.

On 7 June 1966, a C-130 Hercules, piloted by CDR Marion Morris of VX-6, returned to Christchurch after a flight to McMurdo Station to evacuate UT-2 Robert L. Mayfield, who had been critically injured in a fall.
It was the third emergency air evacuation from Antarctica during the winter night.

On 18 June 1967, The first scheduled winter flight to Antarctica was successfully completed when a United States Navy LC-130F of VX-6 flying from Christchurch landed at Williams Field.
Although earlier winter flights had been made to Antarctica as a result of medical emergencies, this was the first planned flight.
On 2 December 1967, an LC-117D Skytrooper landed at McMurdo Station from Hallett Station.
This was the last C-117 flight on the Antarctic continent, marking the end of 11 years of service to VX-6 by the Douglas C-47 Skytrain airframe.

On 1 January 1969, VX-6 was redesignated as Antarctic Development Squadron Six (VXE-6).
In 1957, the first letter of all the east-coast-based VX squadrons, including VX-6, was changed from X to J. In January 1958, a VX-6 UC-1 Otter made the first wheels-on-dirt landing in Antarctica at Marble Point. On 1 October 1959, RADM David M. Tyree (Commander, U.S. Naval Support Force Antarctica from 14 April 1959–26 November 1962) arrived at Naval Air Facility McMurdo Station from Christchurch aboard an R5D Skymaster piloted by LCDR J. A. Henning of VX-6. This first flight of the season marked the operational implementation of Operation Deep Freeze V.
On 9–10 April 1961, the first midwinter medical evacuation flight was conducted to rescue Leonid Kuperov, a seriously ill Soviet scientist, from Byrd Station. Two VX-6 C-130BL Hercules from Quonset Point flew from to Christchurch. One (piloted by CDR Lloyd E. Newcomer) then flew on to Byrd Station to pick up Kuperov, while the other stood by in Christchurch. The total distance flown during this rescue mission was just under 13000 miles.
On 22 February 1963, an LC-130F Hercules of VX-6 made the longest flight in Antarctic history, covering territory never before seen by man. The plane (piloted by CDR William H. Everett and carrying RADM James R. Reedy (Commander, U.S. Naval Support Force Antarctica from November 1962–April 1965) among its passengers, made the 3,470-mile (5,580 km) flight from McMurdo Station, beyond the South Pole to the Shackleton Range and then southeastward to the pole of inaccessibility before returning to McMurdo Station; the duration of this journey was 10 hours and 40 minutes. Also in February 1963, VX-6 completed the first delivery of bulk fuel by a Lockheed LC-130 Hercules.
On 26 June 1964, an LC-130F Hercules, commanded by LT Robert V. Mayer of VX-6, completed a round-trip flight from Christchurch to Antarctica in an emergency evacuation of petty officer B. L. McMullen, critically injured in a fall. As in the earlier medical evacuation of 1961, two planes, with teams of medical specialists on board, flew from NAS Quonset Point to Christchurch where one plane stood by while the other undertook the hazardous flight. On 30 September 1964, three LC-130 Hercules aircraft of VX-6 took off from Melbourne, Christchurch and Punta Arenas, respectively. The three aircraft flew to Antarctica, landing on Williams Field, 7 miles (11 km) from McMurdo Station. The flight from Melbourne, the first in history from Australia to Antarctica, passed over the South Pole to drop a 50-pound sack of mail to the wintering-over party, then landed at Byrd Station before proceeding to McMurdo Station. The arrival of RADM Reedy on this flight marked the official opening of Operation Deep Freeze 1965. Also in 1964, VX-6 conducted the first flight from Cape Town, South Africa to McMurdo Station, the first flight of a U.S. aircraft to the Soviet Vostok Station, and the first successful demonstration of trimetrogon aerial photography, used extensively to map Antarctica.
On 7 June 1966, a C-130 Hercules, piloted by CDR Marion Morris of VX-6, returned to Christchurch after a flight to McMurdo Station to evacuate UT-2 Robert L. Mayfield, who had been critically injured in a fall. It was the third emergency air evacuation from Antarctica during the winter night.
On 18 June 1967, The first scheduled winter flight to Antarctica was successfully completed when a United States Navy LC-130F of VX-6 flying from Christchurch landed at Williams Field. Although earlier winter flights had been made to Antarctica as a result of medical emergencies, this was the first planned flight. On 2 December 1967, an LC-117D Skytrooper landed at McMurdo Station from Hallett Station. This was the last C-117 flight on the Antarctic continent, marking the end of 11 years of service to VX-6 by the Douglas C-47 Skytrain airframe.
On 1 January 1969, VX-6 was redesignated as Antarctic Development Squadron Six (VXE-6).
VX-6