Park's eleventh child, also named James Park, was born in the Park House in 1822.
 The younger James Park graduated from East Tennessee College in 1840 and from Princeton Theological Seminary in 1846, after which he was licensed as a Presbyterian preacher.
 He briefly served as co-principal of the East Tennessee Female Institute before moving to Rogersville in the 1850s to preach at that city's First Presbyterian Church.
 He returned to Knoxville in 1860 to accept a position as principal of the Tennessee School for the Deaf (then located in what is now Old City Hall).

During the Civil War, Park moved to his country home in Cedar Springs (in what is now West Knoxville).
 In late 1863, General James Longstreet, whose army was attempting to retake Knoxville from an occupying Union force, dined at Park's Cedar Springs house.
Park later recalled that Longstreet had an inaccurate map that showed the confluence of the French Broad and Holston rivers to be below Knoxville, and refused to believe Park when he pointed out that the confluence was actually upriver from Knoxville.

After the war, Park was appointed preacher of Knoxville's First Presbyterian Church, and he moved into the James Park House, where he would live for most of the remainder of his life.
 An 1871 map of Knoxville shows the house surrounded by a grove of trees and a few outbuildings, with the St. John's Episcopal Church (predecessor of St. John's Cathedral) across Cumberland to the north.
 An 1886 map, on the other hand, shows the house surrounded by the church and numerous smaller houses, reflecting Knoxville's rapid post-war growth.
Park's eleventh child, also named James Park, was born in the Park House in 1822.  The younger James Park graduated from East Tennessee College in 1840 and from Princeton Theological Seminary in 1846, after which he was licensed as a Presbyterian preacher.  He briefly served as co-principal of the East Tennessee Female Institute before moving to Rogersville in the 1850s to preach at that city's First Presbyterian Church.  He returned to Knoxville in 1860 to accept a position as principal of the Tennessee School for the Deaf (then located in what is now Old City Hall).
During the Civil War, Park moved to his country home in Cedar Springs (in what is now West Knoxville).  In late 1863, General James Longstreet, whose army was attempting to retake Knoxville from an occupying Union force, dined at Park's Cedar Springs house. Park later recalled that Longstreet had an inaccurate map that showed the confluence of the French Broad and Holston rivers to be below Knoxville, and refused to believe Park when he pointed out that the confluence was actually upriver from Knoxville.
After the war, Park was appointed preacher of Knoxville's First Presbyterian Church, and he moved into the James Park House, where he would live for most of the remainder of his life.  An 1871 map of Knoxville shows the house surrounded by a grove of trees and a few outbuildings, with the St. John's Episcopal Church (predecessor of St. John's Cathedral) across Cumberland to the north.  An 1886 map, on the other hand, shows the house surrounded by the church and numerous smaller houses, reflecting Knoxville's rapid post-war growth.
James Park House