GABAA receptors are ligand-gated ion channels.
GABA (gamma-aminobutyric acid), the endogenous ligand for these receptors, is the major inhibitory neurotransmitter in the central nervous system.
When activated, it mediates Cl– flow into the neuron, hyperpolarizing the neuron.
GABAA receptors occur in all organisms that have a nervous system.
Due to their wide distribution within the nervous system of mammals, they play a role in virtually all brain functions.

Various ligands can bind specifically to GABAA receptors, either activating or inhibiting the Cl– channel.

Ligands:
Agonists: GABA, muscimol, progabide, gaboxadol
Antagonists: bicuculine, gabazine
Partial agonist: piperidine-4-sulfonic acid
GABAA receptors are ligand-gated ion channels. GABA (gamma-aminobutyric acid), the endogenous ligand for these receptors, is the major inhibitory neurotransmitter in the central nervous system. When activated, it mediates Cl– flow into the neuron, hyperpolarizing the neuron. GABAA receptors occur in all organisms that have a nervous system. Due to their wide distribution within the nervous system of mammals, they play a role in virtually all brain functions.
Various ligands can bind specifically to GABAA receptors, either activating or inhibiting the Cl– channel.
Ligands:
Agonists: GABA, muscimol, progabide, gaboxadol
Antagonists: bicuculine, gabazine
Partial agonist: piperidine-4-sulfonic acid
Ligand-gated ion channel