The premiere took place a few hours after Leopold's coronation.
The role of Sesto was taken by castrato soprano, Domenico Bedini.
The opera was first performed publicly on 6 September 1791 at the Estates Theatre in Prague.

The opera remained popular for many years after Mozart's death.
It was the first full Mozart opera to reach London, receiving its première there at His Majesty's Theatre on 27 March 1806.
The cast included John Braham, whose long-time companion Nancy Storace had been the first Susanna in The Marriage of Figaro in Vienna.
However, as it was only played once, it does not appear to have attracted much interest.
As far as can be gathered, it was not staged in London again until at the St Pancras Festival in 1957.
The first performance at La Scala in Milan was on 26 December 1818.
The North American premiere was staged on 4 August 1952 at the Berkshire Music Center in Tanglewood.
For a long time, Mozart scholars regarded Tito as an inferior effort of the composer.
Alfred Einstein in 1945 wrote that it was "customary to speak disparagingly of La clemenza di Tito and to dismiss it as the product of haste and fatigue," and he continues the disparagement to some extent by condemning the characters as puppets – e.g., "Tito is nothing but a mere puppet representing magnanimity" – and claiming that the opera seria was already a moribund form.
However, in recent years the opera has undergone something of a reappraisal.
Stanley Sadie considered it to show Mozart "responding with music of restraint, nobility and warmth to a new kind of stimulus".
The opera retains a reasonably high profile, and is in the lower reaches of the 'Top 50' performed at major houses, worldwide
At the Salzburg Festival 2017, Peter Sellars directed his interpretation of the opera, as "a vision of peaceful coexistence", "reaching far beyond the historical context", a coproduction with the Dutch National Opera, Amsterdam, and the Deutsche Oper Berlin.
Conducted by Teodor Currentzis, it premiered on 27 July 2017 at the Felsenreitschule in Salzburg.

The opera was also performed as part of Glyndebourne's 2017 summer festival.
In 2019 the Los Angeles Opera put on the work for the first time in its history in an all new production, conducted by James Conlon and starring Russell Thomas.
In the same year the opera was performed at the Metropolitan Opera in Manhattan and broadcast on April 20, 2019.
The premiere took place a few hours after Leopold's coronation. The role of Sesto was taken by castrato soprano, Domenico Bedini. The opera was first performed publicly on 6 September 1791 at the Estates Theatre in Prague.
The opera remained popular for many years after Mozart's death. It was the first full Mozart opera to reach London, receiving its première there at His Majesty's Theatre on 27 March 1806. The cast included John Braham, whose long-time companion Nancy Storace had been the first Susanna in The Marriage of Figaro in Vienna. However, as it was only played once, it does not appear to have attracted much interest. As far as can be gathered, it was not staged in London again until at the St Pancras Festival in 1957. The first performance at La Scala in Milan was on 26 December 1818. The North American premiere was staged on 4 August 1952 at the Berkshire Music Center in Tanglewood. For a long time, Mozart scholars regarded Tito as an inferior effort of the composer. Alfred Einstein in 1945 wrote that it was "customary to speak disparagingly of La clemenza di Tito and to dismiss it as the product of haste and fatigue," and he continues the disparagement to some extent by condemning the characters as puppets – e.g., "Tito is nothing but a mere puppet representing magnanimity" – and claiming that the opera seria was already a moribund form. However, in recent years the opera has undergone something of a reappraisal. Stanley Sadie considered it to show Mozart "responding with music of restraint, nobility and warmth to a new kind of stimulus". The opera retains a reasonably high profile, and is in the lower reaches of the 'Top 50' performed at major houses, worldwide
At the Salzburg Festival 2017, Peter Sellars directed his interpretation of the opera, as "a vision of peaceful coexistence", "reaching far beyond the historical context", a coproduction with the Dutch National Opera, Amsterdam, and the Deutsche Oper Berlin. Conducted by Teodor Currentzis, it premiered on 27 July 2017 at the Felsenreitschule in Salzburg.
The opera was also performed as part of Glyndebourne's 2017 summer festival. In 2019 the Los Angeles Opera put on the work for the first time in its history in an all new production, conducted by James Conlon and starring Russell Thomas. In the same year the opera was performed at the Metropolitan Opera in Manhattan and broadcast on April 20, 2019.
La clemenza di Tito