On January 30, Bautista was announced as the cover athlete for the Canadian edition of MLB 12: The Show.
In an interleague game against the Milwaukee Brewers on June 19, 2012, Bautista hit the second of three straight solo home runs by the Blue Jays, between Colby Rasmus and Edwin Encarnación, the first time since 2005 that the Jays went back-to-back-to-back with home runs.
 Bautista also took over the MLB lead in home runs for 2012, hitting his 25th on June 27 against the Boston Red Sox, which broke the Blue Jays club record for home runs in a month, with 13.
He went on to finish the month with 14 home runs, one short of the American League record for June.

Bautista was voted an American League starter in the All-Star Game for the second consecutive year and his third overall All-Star selection.
 Hamilton surpassed Bautista's record vote total of the prior year.
 On July 2, Bautista was named American League Player of the Month for June.
 It was his fifth time receiving the honor in his career.
He batted .274 with 14 home runs and 30 RBI in the month of June.
 His 14 home runs in June set a new Blue Jays franchise record for home runs in a month.
Bautista competed in the Home Run Derby.
At the time of his selection, he led all major league players with 26 home runs.
Bautista finished second to Prince Fielder.

Bautista was placed on the 15-day disabled list on July 17 with inflammation in his wrist.
He had started in all previous 90 games, and the Blue Jays called up prospect Anthony Gose to take his place after the game.
Bautista was activated on August 24, but returned to the disabled list on August 26 after he re-aggravated the injury to his left wrist.
On August 28, the Jays announced that he would undergo season-ending surgery on the wrist.
In 2012, Bautista batted .241 with 27 home runs and 65 RBI in 92 games.
On January 30, Bautista was announced as the cover athlete for the Canadian edition of MLB 12: The Show. In an interleague game against the Milwaukee Brewers on June 19, 2012, Bautista hit the second of three straight solo home runs by the Blue Jays, between Colby Rasmus and Edwin Encarnación, the first time since 2005 that the Jays went back-to-back-to-back with home runs.  Bautista also took over the MLB lead in home runs for 2012, hitting his 25th on June 27 against the Boston Red Sox, which broke the Blue Jays club record for home runs in a month, with 13. He went on to finish the month with 14 home runs, one short of the American League record for June.
Bautista was voted an American League starter in the All-Star Game for the second consecutive year and his third overall All-Star selection.  Hamilton surpassed Bautista's record vote total of the prior year.  On July 2, Bautista was named American League Player of the Month for June.  It was his fifth time receiving the honor in his career. He batted .274 with 14 home runs and 30 RBI in the month of June.  His 14 home runs in June set a new Blue Jays franchise record for home runs in a month. Bautista competed in the Home Run Derby. At the time of his selection, he led all major league players with 26 home runs. Bautista finished second to Prince Fielder.
Bautista was placed on the 15-day disabled list on July 17 with inflammation in his wrist. He had started in all previous 90 games, and the Blue Jays called up prospect Anthony Gose to take his place after the game. Bautista was activated on August 24, but returned to the disabled list on August 26 after he re-aggravated the injury to his left wrist. On August 28, the Jays announced that he would undergo season-ending surgery on the wrist. In 2012, Bautista batted .241 with 27 home runs and 65 RBI in 92 games.
José Bautista