De Vanna played four games at the 2004 Olympic Football Tournament.

She scored four goals for Australia in the 2007 World Cup — one in a 1–1 draw against Norway, two in a 4–1 victory against Ghana, and one against Brazil in her team's 2–3 loss in the quarterfinals.
Each goal she scored at the World Cup was dedicated to her father, who died three months before the tournament began.

On 1 October 2007 Lisa was named in the FIFA's Women's World Cup All Star Team and she was also nominated for the 2007 FIFA World Player of the Year award.
She was named Western Australian Sportswoman of the Year in 2007.
After returning home after the World Cup De Vanna returned to a job at a petrol station.

In May 2011 De Vanna was sent home from a training camp held to prepare the national team for the World Cup.
Australian coach Tom Sermanni stated that the expulsion was for an unacceptable standard of behaviour.
The previous September, De Vanna had been subject to a complaint after photographs involving a large inflatable penis were posted to her Facebook page.
She was censured by Football Federation Australia and instructed to remove the offending pictures.
De Vanna moved to Sweden for the 2012/13 season, but discussed that her desire to play for The Matildas was then stronger than ever.

On 8 June 2015 De Vanna captained the Matilda's in her 100th game, scoring their only goal in a 3–1 defeat to the United States in the 2015 FIFA Women's World Cup.
During a match against Brazil in the 2016 Olympics, a moment of De Vanna and teammate Elise Kellond-Knight went viral when during a short break, De Vanna absentmindedly tried to drink from the wrong end of a water bottle, prompting Kellond-Knight to quickly flip it in her hand.

Presently, De Vanna is the highest goal scorer in Matildas history, with 47.
De Vanna played four games at the 2004 Olympic Football Tournament.
She scored four goals for Australia in the 2007 World Cup — one in a 1–1 draw against Norway, two in a 4–1 victory against Ghana, and one against Brazil in her team's 2–3 loss in the quarterfinals. Each goal she scored at the World Cup was dedicated to her father, who died three months before the tournament began.
On 1 October 2007 Lisa was named in the FIFA's Women's World Cup All Star Team and she was also nominated for the 2007 FIFA World Player of the Year award. She was named Western Australian Sportswoman of the Year in 2007. After returning home after the World Cup De Vanna returned to a job at a petrol station.
In May 2011 De Vanna was sent home from a training camp held to prepare the national team for the World Cup. Australian coach Tom Sermanni stated that the expulsion was for an unacceptable standard of behaviour. The previous September, De Vanna had been subject to a complaint after photographs involving a large inflatable penis were posted to her Facebook page. She was censured by Football Federation Australia and instructed to remove the offending pictures. De Vanna moved to Sweden for the 2012/13 season, but discussed that her desire to play for The Matildas was then stronger than ever.
On 8 June 2015 De Vanna captained the Matilda's in her 100th game, scoring their only goal in a 3–1 defeat to the United States in the 2015 FIFA Women's World Cup. During a match against Brazil in the 2016 Olympics, a moment of De Vanna and teammate Elise Kellond-Knight went viral when during a short break, De Vanna absentmindedly tried to drink from the wrong end of a water bottle, prompting Kellond-Knight to quickly flip it in her hand.
Presently, De Vanna is the highest goal scorer in Matildas history, with 47.
Lisa De Vanna