On November 3, Vanderbilt lost to the Michigan Wolverines by a 10–4 score.
The game remained tied at 4–4 until the closing minutes.
The Masonic Theater in Nashville was crowded with those who had come to see the game detailed.

Before the game, Michigan coach Fielding Yost said: "I have said right along that the Vanderbilt team would come nearer beating us than any team ever did...In Craig, Blake, and Manier I think Vanderbilt has the three greatest backs of any one team in the country."
On the night just before the game, 4,200 students attended a mass meeting at University Hall.
McGugin and Yost both spoke to the crowd and agreed that the game would be one of the closest played in Ann Arbor in many years.
D. G. Fite, father-in-law of both McGugin and Yost, traveled from his home in Tennessee to watch the game.

John Garrels put Michigan ahead with a field goal from the 25-yard line.
On the preceding drive, Garrels had completed a 15-yard forward pass to Bishop, the first legal forward pass completed by Michigan under the new rules.
Michigan led, 4–0, at halftime.
Early in the second half, Vanderbilt tied the score with a field goal by Dan Blake from the 30-yard line.
With two minutes left in the game, Garrels ran 68 yards for a touchdown.
 The Chicago Daily Tribune wrote: "Garrels, on a fake kick, with splendid interference by Hammond, Curtis, and Workman, ran Vanderbilt's left end at lightning speed for sixty-eight yards and a touchdown."
Curtis kicked the extra point, and Michigan led, 10–4.

The starting lineup was: V. Blake (left end); Pritchard (left tackle); Chorn (left guard); Stone (center); McLain (right guard); E. Noel (right tackle); B. Blake (right end); Costen (quarterback); Craig (left halfback); D. Blake (right halfback); Manier (fullback).
On November 3, Vanderbilt lost to the Michigan Wolverines by a 10–4 score. The game remained tied at 4–4 until the closing minutes. The Masonic Theater in Nashville was crowded with those who had come to see the game detailed.
Before the game, Michigan coach Fielding Yost said: "I have said right along that the Vanderbilt team would come nearer beating us than any team ever did...In Craig, Blake, and Manier I think Vanderbilt has the three greatest backs of any one team in the country." On the night just before the game, 4,200 students attended a mass meeting at University Hall. McGugin and Yost both spoke to the crowd and agreed that the game would be one of the closest played in Ann Arbor in many years. D. G. Fite, father-in-law of both McGugin and Yost, traveled from his home in Tennessee to watch the game.
John Garrels put Michigan ahead with a field goal from the 25-yard line. On the preceding drive, Garrels had completed a 15-yard forward pass to Bishop, the first legal forward pass completed by Michigan under the new rules. Michigan led, 4–0, at halftime. Early in the second half, Vanderbilt tied the score with a field goal by Dan Blake from the 30-yard line. With two minutes left in the game, Garrels ran 68 yards for a touchdown.  The Chicago Daily Tribune wrote: "Garrels, on a fake kick, with splendid interference by Hammond, Curtis, and Workman, ran Vanderbilt's left end at lightning speed for sixty-eight yards and a touchdown." Curtis kicked the extra point, and Michigan led, 10–4.
The starting lineup was: V. Blake (left end); Pritchard (left tackle); Chorn (left guard); Stone (center); McLain (right guard); E. Noel (right tackle); B. Blake (right end); Costen (quarterback); Craig (left halfback); D. Blake (right halfback); Manier (fullback).
1906 Vanderbilt Commodores football team