Despite Roma's disappointing 2004–05 season, which saw the departure of a number of players and several managerial changes, Totti maintained consistent form by scoring 12 goals in Serie A, and 15 in all competitions, among which was his 100th Serie A goal from a free kick in a 3–3 draw against Internazionale, on 3 October 2004.
Two months later, on 19 December, he became Roma's all-time leading scorer in Serie A after netting his 107th career league goal against Parma, breaking the record previously held by Roberto Pruzzo.
Although Roma finished the league season in eighth place, Totti helped the team reach the 2005 Coppa Italia final; however Roma lost to Inter.

Roma's new coach for the 2005–06 season, Luciano Spalletti, went with a 4–2–3–1 formation, deploying Totti in a newer, more offensive role as a lone striker.
Despite his new attacking role, Totti usually dropped deep to pick up the ball in midfield rather than operating in the penalty area, thus creating space for the attacking midfielders and wingers to making offensive runs; the resulting system was later described as a 4–6–0, while Totti's particular attacking role was dubbed the "false-9".
In this new position, Totti continued to score frequently, managing 15 goals in 24 league matches.
In the spring of 2005, he renewed his contract until 2010, with an annual salary of €5.4 million.
On 19 February 2006, he suffered a fracture of his left fibula and ligament damage during a match against Empoli after being fouled by Richard Vanigli.
Totti was at risk of missing the 2006 World Cup, but returned to the side on 11 May 2006 as a substitute in Roma's 3–1 Coppa Italia final defeat to Inter.
A metal plate had been attached to his ankle during surgery, but doctors decided not to operate again and remove it following Totti's return, concurring that the plate would not affect his game.
He was given off-label treatments of teriparatide to speed-up his fracture recovery.

The 2006–07 season was a personal high for Totti as he scored 26 goals in Serie A, as well as another six between the Champions League (scoring three times in the group stage and once in the round of 16 tie against Lyon) and the Coppa Italia, in addition to 15 assists in 50 games across all competitions.
Despite their elimination from the Champions League by Manchester United in the quarter-finals, and a second-place finish in the league, Roma won the Coppa Italia final against league champions Inter with a 6–2 victory at home (Totti scored the opening goal after 50 seconds) and a 2–1 defeat at the San Siro in Milan.
Totti finished the season as Serie A top scorer with 26 goals, and on 17 June, he also received the ESM European Golden Shoe award as the top European goalscorer of the season.
Despite being the highest active goalscorer in Serie A, he was not among the finalists for the 2007 FIFA World Player of the Year due to his absence from the national team, although he was nominated for the 2007 Ballon d'Or, finishing tenth in the voting.

On 19 August 2007, Totti contributed to Roma's 1–0 victory over Inter in the 2007 Supercoppa Italiana, winning a penalty which was subsequently converted by Daniele De Rossi.
Totti scored his 200th goal for Roma in a 4–0 victory against Torino, in the Coppa Italia, on 16 January 2008.
He was named the Serie A Italian Footballer of the Year for the fifth time in his career on 28 January.
The following month, on 24 February, he reached 386 appearances in Serie A with Roma in a match against Fiorentina, equalling the club appearance record previously held by Giacomo Losi, Roma's captain in the 1960s.
He broke the record on 27 February, in the club's following league match against Inter.
On 9 March, he reached his 500th overall appearance for Roma, scoring the second goal of the match from a penalty kick in a 2–0 away win over Napoli.
Totti suffered a season-ending injury to his right knee during a 1–1 draw with Livorno on 19 April.
Tests revealed a tear of his anterior cruciate ligament (ACL) that required surgery, ruling him out for four months.
Roma won their ninth Co
Despite Roma's disappointing 2004–05 season, which saw the departure of a number of players and several managerial changes, Totti maintained consistent form by scoring 12 goals in Serie A, and 15 in all competitions, among which was his 100th Serie A goal from a free kick in a 3–3 draw against Internazionale, on 3 October 2004. Two months later, on 19 December, he became Roma's all-time leading scorer in Serie A after netting his 107th career league goal against Parma, breaking the record previously held by Roberto Pruzzo. Although Roma finished the league season in eighth place, Totti helped the team reach the 2005 Coppa Italia final; however Roma lost to Inter.
Roma's new coach for the 2005–06 season, Luciano Spalletti, went with a 4–2–3–1 formation, deploying Totti in a newer, more offensive role as a lone striker. Despite his new attacking role, Totti usually dropped deep to pick up the ball in midfield rather than operating in the penalty area, thus creating space for the attacking midfielders and wingers to making offensive runs; the resulting system was later described as a 4–6–0, while Totti's particular attacking role was dubbed the "false-9". In this new position, Totti continued to score frequently, managing 15 goals in 24 league matches. In the spring of 2005, he renewed his contract until 2010, with an annual salary of €5.4 million. On 19 February 2006, he suffered a fracture of his left fibula and ligament damage during a match against Empoli after being fouled by Richard Vanigli. Totti was at risk of missing the 2006 World Cup, but returned to the side on 11 May 2006 as a substitute in Roma's 3–1 Coppa Italia final defeat to Inter. A metal plate had been attached to his ankle during surgery, but doctors decided not to operate again and remove it following Totti's return, concurring that the plate would not affect his game. He was given off-label treatments of teriparatide to speed-up his fracture recovery.
The 2006–07 season was a personal high for Totti as he scored 26 goals in Serie A, as well as another six between the Champions League (scoring three times in the group stage and once in the round of 16 tie against Lyon) and the Coppa Italia, in addition to 15 assists in 50 games across all competitions. Despite their elimination from the Champions League by Manchester United in the quarter-finals, and a second-place finish in the league, Roma won the Coppa Italia final against league champions Inter with a 6–2 victory at home (Totti scored the opening goal after 50 seconds) and a 2–1 defeat at the San Siro in Milan. Totti finished the season as Serie A top scorer with 26 goals, and on 17 June, he also received the ESM European Golden Shoe award as the top European goalscorer of the season. Despite being the highest active goalscorer in Serie A, he was not among the finalists for the 2007 FIFA World Player of the Year due to his absence from the national team, although he was nominated for the 2007 Ballon d'Or, finishing tenth in the voting.
On 19 August 2007, Totti contributed to Roma's 1–0 victory over Inter in the 2007 Supercoppa Italiana, winning a penalty which was subsequently converted by Daniele De Rossi. Totti scored his 200th goal for Roma in a 4–0 victory against Torino, in the Coppa Italia, on 16 January 2008. He was named the Serie A Italian Footballer of the Year for the fifth time in his career on 28 January. The following month, on 24 February, he reached 386 appearances in Serie A with Roma in a match against Fiorentina, equalling the club appearance record previously held by Giacomo Losi, Roma's captain in the 1960s. He broke the record on 27 February, in the club's following league match against Inter. On 9 March, he reached his 500th overall appearance for Roma, scoring the second goal of the match from a penalty kick in a 2–0 away win over Napoli. Totti suffered a season-ending injury to his right knee during a 1–1 draw with Livorno on 19 April. Tests revealed a tear of his anterior cruciate ligament (ACL) that required surgery, ruling him out for four months. Roma won their ninth Co
Francesco Totti