The Knoxville High School building, located on East Fifth Avenue in Knoxville, was completed in 1910, enrolling male and female students who had previously attended separate high schools.
 W. J. Barton was the school's first principal.
W. E. Evans served as principal from 1917 until the school closed in 1951.
Enrollment grew to just over 2,000 in the early 1920s and reached a peak of about 2,300 around the beginning of World War II.

The school was known for many years as a school sports powerhouse, winning a total of 13 Tennessee state championships and six Southern championships in football, as well as national championships in 1930 and 1937.

By 1948, the building had become inadequate, and city schools Superintendent Tom Prince warned that the Southern Association of Colleges and Secondary Schools was threatening to strip Knoxville High's accreditation.
 In response, the city built three new schools: Fulton High School, West High School, East High School, and made improvements  to South High School and Austin High.
 Knoxville High closed in 1951.

After the school was closed, the city school district used the building for administrative offices.
Following consolidation of the city and county schools, Knox County Schools has used the building for adult education.
The Knoxville High School building, located on East Fifth Avenue in Knoxville, was completed in 1910, enrolling male and female students who had previously attended separate high schools.  W. J. Barton was the school's first principal. W. E. Evans served as principal from 1917 until the school closed in 1951. Enrollment grew to just over 2,000 in the early 1920s and reached a peak of about 2,300 around the beginning of World War II.
The school was known for many years as a school sports powerhouse, winning a total of 13 Tennessee state championships and six Southern championships in football, as well as national championships in 1930 and 1937.
By 1948, the building had become inadequate, and city schools Superintendent Tom Prince warned that the Southern Association of Colleges and Secondary Schools was threatening to strip Knoxville High's accreditation.  In response, the city built three new schools: Fulton High School, West High School, East High School, and made improvements  to South High School and Austin High.  Knoxville High closed in 1951.
After the school was closed, the city school district used the building for administrative offices. Following consolidation of the city and county schools, Knox County Schools has used the building for adult education.
Knoxville High School (Tennessee)