In 1929, she pioneered the design of glass sculpture for the Royal Leerdam Crystal Glass Factory in the Netherlands.
When Frank Lloyd Wright saw her glass works and spoke with her in New York, he invited her to teach at his architectural school, Taliesin East, where she worked with artist and muralist Santiago Martínez Delgado and other Taliesin fellows.

Then, in 1931, Bloch had met and began her apprenticeship with Diego Rivera on his frescoes in New York (1931, 1933) and Detroit (1932).
She also formed a close friendship with Rivera's wife Frida Kahlo, and they became each other's companion and confidant.
In 1932 she accompanied Kahlo to Mexico when Kahlo's mother became ill.
She was also with Kahlo in Detroit when Kahlo had her miscarriage.

A prolific photographer, Bloch contributed many photographs of Rivera and Kahlo to biographical works about them.
She took the only existing photographs of Rivera's (controversially) destroyed mural, Man at the Crossroads, in Rockefeller Center Plaza in New York City.
She created five portfolios of photographs of Rivera and Kahlo, including photos of Kahlo's paintings in progress, and the artists in New York City, Detroit, and Mexico.
The apprentices there were:  Bloch, Stephen Pope Dimitroff, Lou Block, Arthur Niendorf, Seymour Fogel, Hideo Noda, and Antonio Sanchez Flores.
In 1929, she pioneered the design of glass sculpture for the Royal Leerdam Crystal Glass Factory in the Netherlands. When Frank Lloyd Wright saw her glass works and spoke with her in New York, he invited her to teach at his architectural school, Taliesin East, where she worked with artist and muralist Santiago Martínez Delgado and other Taliesin fellows.
Then, in 1931, Bloch had met and began her apprenticeship with Diego Rivera on his frescoes in New York (1931, 1933) and Detroit (1932). She also formed a close friendship with Rivera's wife Frida Kahlo, and they became each other's companion and confidant. In 1932 she accompanied Kahlo to Mexico when Kahlo's mother became ill. She was also with Kahlo in Detroit when Kahlo had her miscarriage.
A prolific photographer, Bloch contributed many photographs of Rivera and Kahlo to biographical works about them. She took the only existing photographs of Rivera's (controversially) destroyed mural, Man at the Crossroads, in Rockefeller Center Plaza in New York City. She created five portfolios of photographs of Rivera and Kahlo, including photos of Kahlo's paintings in progress, and the artists in New York City, Detroit, and Mexico. The apprentices there were:  Bloch, Stephen Pope Dimitroff, Lou Block, Arthur Niendorf, Seymour Fogel, Hideo Noda, and Antonio Sanchez Flores.
Lucienne Bloch