The biggest church in Guardiagrele is Santa Maria Maggiore of which it has been written:
The façade presents a splendid 14th-century gothic portal, among the most elegant in the Abruzzi Gothic style.
 The Coronation of the Virgin sculpture group in the portal lunette is also magnificent, attributed to the school of Nicola di Guardiagrele.
 Under the colonnaded portico, next to the lateral door, is the splendid fresco by Andrea De Litio (1473) portraying Saint Christopher.
In the interior, completely rebuilt in the 18th century following an earthquake, crumbling stucco-work in the Baroque style and a shrine of the same period set off a 15th-century fresco representing the Madonna of the Milk.

In addition to Santa Maria Maggiore, there are  several other churches and  palazzi or mansions of various ages which are of architectural interest, including   S. Nicola di Bari (founded in the 4th century), the convent of the Chapuchins (1599), Palazzo De Lucia (16th century), Palazzo Elisii (15th-18th century), the cloister of the  Palazzo Comunale Piazza San Francesco (17th century) and Palazzo Marini (1391).

Museums include:
Museo Civico (Civic Museum)
Museo del Costume e della Tradizione della Nostra Gente (Costume and Folk Museum)
Museo del Duomo ("Cathedral Museum"), in Santa Maria Maggiore
Museo Archeologico ("Archaeological Museum").
The biggest church in Guardiagrele is Santa Maria Maggiore of which it has been written:
The façade presents a splendid 14th-century gothic portal, among the most elegant in the Abruzzi Gothic style.  The Coronation of the Virgin sculpture group in the portal lunette is also magnificent, attributed to the school of Nicola di Guardiagrele.  Under the colonnaded portico, next to the lateral door, is the splendid fresco by Andrea De Litio (1473) portraying Saint Christopher. In the interior, completely rebuilt in the 18th century following an earthquake, crumbling stucco-work in the Baroque style and a shrine of the same period set off a 15th-century fresco representing the Madonna of the Milk.
In addition to Santa Maria Maggiore, there are  several other churches and  palazzi or mansions of various ages which are of architectural interest, including   S. Nicola di Bari (founded in the 4th century), the convent of the Chapuchins (1599), Palazzo De Lucia (16th century), Palazzo Elisii (15th-18th century), the cloister of the  Palazzo Comunale Piazza San Francesco (17th century) and Palazzo Marini (1391).
Museums include:
Museo Civico (Civic Museum)
Museo del Costume e della Tradizione della Nostra Gente (Costume and Folk Museum)
Museo del Duomo ("Cathedral Museum"), in Santa Maria Maggiore
Museo Archeologico ("Archaeological Museum").
Guardiagrele