In 1849 the Brothers, Priests and Sisters of Holy Cross arrived in New Orleans after they had established the University of Notre Dame in South Bend, Indiana, and took over an orphanage for the boys and girls who survived a plague.
The orphanage, along with the first Ursuline School for Girls (the oldest Catholic School in America), was destroyed to make room for the 1923 Industrial Canal, which experienced levee failures that flooded large parts of New Orleans twice, with Hurricane Betsy in 1965 and Hurricane Katrina in 2005.

In 1871, Holy Cross moved to its historic site, which then was a farm named St. Isidore's farm, on 4950 Dauphine Street, and built a renowned "collegiate-styled campus" and established in 1879 its current school, bordered by the high Mississippi River levee.
The area has since become a Federal Historic District known as the "Holy Cross Historic District."

First chartered by the State of Louisiana in 1890, the name was changed to Holy Cross in 1895 when the present Administration Building was dedicated.
A boarding program, which continued until 1973, attracted as many as 150 students annually from across the South as well as from Central and South America.

Prior to 2015 Holy Cross had grades 5-12.
The archdiocese began requiring schools to fit one of three grade configurations (PK-7, 8-12, or PK-12) in order to continue affiliation, and Holy Cross needed to change its grade configuration.
The school administration decided for the school to become K-12.
In 1849 the Brothers, Priests and Sisters of Holy Cross arrived in New Orleans after they had established the University of Notre Dame in South Bend, Indiana, and took over an orphanage for the boys and girls who survived a plague. The orphanage, along with the first Ursuline School for Girls (the oldest Catholic School in America), was destroyed to make room for the 1923 Industrial Canal, which experienced levee failures that flooded large parts of New Orleans twice, with Hurricane Betsy in 1965 and Hurricane Katrina in 2005.
In 1871, Holy Cross moved to its historic site, which then was a farm named St. Isidore's farm, on 4950 Dauphine Street, and built a renowned "collegiate-styled campus" and established in 1879 its current school, bordered by the high Mississippi River levee. The area has since become a Federal Historic District known as the "Holy Cross Historic District."
First chartered by the State of Louisiana in 1890, the name was changed to Holy Cross in 1895 when the present Administration Building was dedicated. A boarding program, which continued until 1973, attracted as many as 150 students annually from across the South as well as from Central and South America.
Prior to 2015 Holy Cross had grades 5-12. The archdiocese began requiring schools to fit one of three grade configurations (PK-7, 8-12, or PK-12) in order to continue affiliation, and Holy Cross needed to change its grade configuration. The school administration decided for the school to become K-12.
Holy Cross School (New Orleans)