The 1560s brought to Russia hardships that led to a dramatic change of Ivan's policies.
Russia was devastated by a combination of drought: famine; unsuccessful wars against the Polish–Lithuanian Commonwealth; Tatar invasions and the sea-trading blockade carried out by the Swedes, Poles and the Hanseatic League.
His first wife, Anastasia Romanovna, died in 1560, which was suspected to be a poisoning.
The personal tragedy deeply hurt Ivan and is thought to have affected his personality, if not his mental health.
At the same time, one of Ivan's advisors, Prince Andrei Kurbsky, defected to the Lithuanians, took command of the Lithuanian troops and devastated the Russian region of Velikiye Luki.
That series of treasons made Ivan paranoically suspicious of nobility.

On 3 December 1564, Ivan departed Moscow for Aleksandrova Sloboda, where he sent two letters in which he announced his abdication because of the alleged embezzlement and treason of the aristocracy and the clergy.
The boyar court was unable to rule in Ivan's absence and feared the wrath of the Muscovite citizens.
A boyar envoy departed for Aleksandrova Sloboda to beg Ivan to return to the throne.
Ivan agreed to return on condition of being granted absolute power.
He demanded to be able to execute and confiscate the estates of traitors without interference from the boyar council or church.
Ivan decreed the creation of the oprichnina.

That was a separate territory within the borders of Russia, mostly in the territory of the former Novgorod Republic in the north.
Ivan held exclusive power over the territory.
The Boyar Council ruled the zemshchina ('land'), the second division of the state.
Ivan also recruited a personal guard known as the Oprichniki.
Originally it numbered 1000.
The oprichniki were headed by Malyuta Skuratov.
One known oprichnik was the German adventurer Heinrich von Staden.
The oprichniki enjoyed social and economic privileges under the oprichnina.
They owed their allegiance and status to Ivan, not heredity or local bonds.

The first wave of persecutions targeted primarily the princely clans of Russia, notably the influential families of Suzdal.
Ivan executed, exiled or forcibly tonsured prominent members of the boyar clans on questionable accusations of conspiracy.
Among those who were executed were the Metropolitan Philip and the prominent warlord Alexander Gorbaty-Shuisky.
In 1566, Ivan extended the oprichnina to eight central districts.
Of the 12,000 nobles, 570 became oprichniki and the rest were expelled.

Under the new political system, the oprichniki were given large estates but, unlike the previous landlords, could not be held accountable for their actions.
The men "took virtually all the peasants possessed, forcing them to pay 'in one year as much as [they] used to pay in ten.'"
That degree of oppression resulted in increasing cases of peasants fleeing, which, in turn, reduced the overall production.
The price of grain increased ten times.
The 1560s brought to Russia hardships that led to a dramatic change of Ivan's policies. Russia was devastated by a combination of drought: famine; unsuccessful wars against the Polish–Lithuanian Commonwealth; Tatar invasions and the sea-trading blockade carried out by the Swedes, Poles and the Hanseatic League. His first wife, Anastasia Romanovna, died in 1560, which was suspected to be a poisoning. The personal tragedy deeply hurt Ivan and is thought to have affected his personality, if not his mental health. At the same time, one of Ivan's advisors, Prince Andrei Kurbsky, defected to the Lithuanians, took command of the Lithuanian troops and devastated the Russian region of Velikiye Luki. That series of treasons made Ivan paranoically suspicious of nobility.
On 3 December 1564, Ivan departed Moscow for Aleksandrova Sloboda, where he sent two letters in which he announced his abdication because of the alleged embezzlement and treason of the aristocracy and the clergy. The boyar court was unable to rule in Ivan's absence and feared the wrath of the Muscovite citizens. A boyar envoy departed for Aleksandrova Sloboda to beg Ivan to return to the throne. Ivan agreed to return on condition of being granted absolute power. He demanded to be able to execute and confiscate the estates of traitors without interference from the boyar council or church. Ivan decreed the creation of the oprichnina.
That was a separate territory within the borders of Russia, mostly in the territory of the former Novgorod Republic in the north. Ivan held exclusive power over the territory. The Boyar Council ruled the zemshchina ('land'), the second division of the state. Ivan also recruited a personal guard known as the Oprichniki. Originally it numbered 1000. The oprichniki were headed by Malyuta Skuratov. One known oprichnik was the German adventurer Heinrich von Staden. The oprichniki enjoyed social and economic privileges under the oprichnina. They owed their allegiance and status to Ivan, not heredity or local bonds.
The first wave of persecutions targeted primarily the princely clans of Russia, notably the influential families of Suzdal. Ivan executed, exiled or forcibly tonsured prominent members of the boyar clans on questionable accusations of conspiracy. Among those who were executed were the Metropolitan Philip and the prominent warlord Alexander Gorbaty-Shuisky. In 1566, Ivan extended the oprichnina to eight central districts. Of the 12,000 nobles, 570 became oprichniki and the rest were expelled.
Under the new political system, the oprichniki were given large estates but, unlike the previous landlords, could not be held accountable for their actions. The men "took virtually all the peasants possessed, forcing them to pay 'in one year as much as [they] used to pay in ten.'" That degree of oppression resulted in increasing cases of peasants fleeing, which, in turn, reduced the overall production. The price of grain increased ten times.
Ivan the Terrible