Sir Francis Sacheverel Darwin was the son of Erasmus Darwin and Elizabeth (née Collier), daughter of Charles Colyear, 2nd Earl of Portmore.
Francis was an accomplished travel writer, explorer and naturalist and bravely studied the ravages of the plague on Smyrna at great personal risk.
He was the only one to return of his friends who went to the East.
A physician to George III, he was knighted by George IV.

On 16 December 1815 he married Jane Harriet Ryle (11 December 1794 – 19 April 1866) at St. George, Hanover Square London.
They had many children including:
Mary Jane Darwin (12 February 1817 – 1872), married Charles Carill-Worsley of Platt Hall, near Manchester, in 1840.
 (Their daughter, Elizabeth, who married Nicolas Tindal, later Tindal-Carill-Worsley, was the mother of Charles and Ralph Tindal-Carill-Worsley – see under 5th generation).

Frances Sarah Darwin (19 July 1822 – 1881), married Gustavus Barton in 1845, widowed 1846 and remarried to Marcus Huish during 1849.
 She is the stepmother of the art dealer Marcus Bourne Huish.

Edward Levett Darwin (12 April 1821 – 23 April 1901), married Harriett Jessopp during 1850.
A solicitor in Matlock Bath, Derbyshire, Edward Levett Darwin was the author, using the pseudonym "High Elms", of Gameskeeper's Manual, a guide for tending game on large estates which shows keen observation of the habits of various animals.
Sir Francis Sacheverel Darwin was the son of Erasmus Darwin and Elizabeth (née Collier), daughter of Charles Colyear, 2nd Earl of Portmore. Francis was an accomplished travel writer, explorer and naturalist and bravely studied the ravages of the plague on Smyrna at great personal risk. He was the only one to return of his friends who went to the East. A physician to George III, he was knighted by George IV.
On 16 December 1815 he married Jane Harriet Ryle (11 December 1794 – 19 April 1866) at St. George, Hanover Square London. They had many children including:
Mary Jane Darwin (12 February 1817 – 1872), married Charles Carill-Worsley of Platt Hall, near Manchester, in 1840.  (Their daughter, Elizabeth, who married Nicolas Tindal, later Tindal-Carill-Worsley, was the mother of Charles and Ralph Tindal-Carill-Worsley – see under 5th generation).
Frances Sarah Darwin (19 July 1822 – 1881), married Gustavus Barton in 1845, widowed 1846 and remarried to Marcus Huish during 1849.  She is the stepmother of the art dealer Marcus Bourne Huish.
Edward Levett Darwin (12 April 1821 – 23 April 1901), married Harriett Jessopp during 1850. A solicitor in Matlock Bath, Derbyshire, Edward Levett Darwin was the author, using the pseudonym "High Elms", of Gameskeeper's Manual, a guide for tending game on large estates which shows keen observation of the habits of various animals.
Darwin–Wedgwood family