Mbombo, who previously was an African National Congress supporter, joined the DA in 2013, after attending a DA meeting of black professionals.

Mbombo was elected to the Western Cape Provincial Parliament in 2014.
She was sworn in as a Member on 21 May 2014.
She represents the Philippi region of the City of Cape Town.
Premier Helen Zille appointed Mbombo to the post of Western Cape Provincial Minister of Cultural Affairs and Sport.
She was sworn in as Provincial Minister on 26 May 2014.

In December 2014, Premier Zille announced that Theuns Botha and Mbombo would exchange ministerial positions.
Mbombo would become Western Cape Provincial Minister of Health, while Botha would take her position.
The changes came into effect on 1 January 2015.

In 2018, incumbent Democratic Alliance Women's Network Federal Leader Denise Robinson announced that she would not seek re-election to another term.
Mbombo subsequently declared her candidacy and was elected on 7 April 2018 at the party's Federal Congress.

In May 2019, newly elected premier Alan Winde announced that he had retained Mbombo in her post as Provincial Minister of Health.

In October 2019, she declared her candidacy for interim Federal Chairperson of the Democratic Alliance following Athol Trollip's resignation.
She lost to Ivan Meyer.
Mbombo, who previously was an African National Congress supporter, joined the DA in 2013, after attending a DA meeting of black professionals.
Mbombo was elected to the Western Cape Provincial Parliament in 2014. She was sworn in as a Member on 21 May 2014. She represents the Philippi region of the City of Cape Town. Premier Helen Zille appointed Mbombo to the post of Western Cape Provincial Minister of Cultural Affairs and Sport. She was sworn in as Provincial Minister on 26 May 2014.
In December 2014, Premier Zille announced that Theuns Botha and Mbombo would exchange ministerial positions. Mbombo would become Western Cape Provincial Minister of Health, while Botha would take her position. The changes came into effect on 1 January 2015.
In 2018, incumbent Democratic Alliance Women's Network Federal Leader Denise Robinson announced that she would not seek re-election to another term. Mbombo subsequently declared her candidacy and was elected on 7 April 2018 at the party's Federal Congress.
In May 2019, newly elected premier Alan Winde announced that he had retained Mbombo in her post as Provincial Minister of Health.
In October 2019, she declared her candidacy for interim Federal Chairperson of the Democratic Alliance following Athol Trollip's resignation. She lost to Ivan Meyer.
Nomafrench Mbombo