In 1530, the Valley of Tlaltenango was inhabited by the indigenous Caxcans who farmed the land on the river banks and certainly enjoyed the abundance of flora and fauna of the mountain ranges that surrounded the valley.
 The meaning of the word Tlaltenango in the Caxcan language (land surrounded by walls) alludes to the mountainous landscape of the valley.

Between these walls, the Sierra del Mixtón to the east and the Sierra de Tepeque to the west, transited Nuño Beltrán de Guzmán and his soldiers, leaving, according to the historian Peter Gerhard, “a path of corpses and destroyed houses and crops, impressing surviving males into service and leaving women and children to starve.”
 Frame 56 of the Lienzo de Tlaxcala describes a battle in which the Caxcans of “Tlaltenapa” defended their lands against the Spanish and their Tlaxcaltec allies.

The memories of this first encounter with the Spanish must have tormented the inhabitants of Tlaltenango and its surrounding area.
 So great was the anguish that in 1531, from the mountains near El Teúl, they launched an attack against the Spanish who were attempting to build a town named the Town of the Holy Spirit of Guadalajara near what is now Nochistlán.
 The Town of Guadalajara was left in ruins and the Spanish had to make another three attempts before the town finally survived in its present location (the Atemajac Valley) where it was built in 1542.

In 1541, the Caxcans took up arms against the Spanish once again, with their Tepehuan, Zacatec and Guachichil allies.
 From the Sierra del Mixtón, which is today known as Sierra de Morones, the indigenous allies of the region attacked the Spanish.
 The Mixtón War lasted less than two years, but peace was not long-lived.
 In 1550, the seeds of war sprouted once again with the great Chichimeca War, a war fought by a great number of Chichimec ethnic groups (Chichimec was a pejorative term used by civilized ethnic groups of the south to describe the nomadic ethnic groups of the north).
 This war lasted almost forty years.
 While it seems that the residents of the Valley of Tlaltenango did not participate in this rebellion, the region suffered the consequences of war nevertheless due to the chaos all around it.
 For having submitted to the Spanish Crown, The Caxcan towns of the area around Tlaltenango suffered attacks from the north launched by their former allies, the Zacatecs.

The war only came to an end when the Viceroy Luís de Velasco decided to purchase peace with the Chichimecs.
 As part of the peace offering, the Viceroy used the power of the Royal Treasury to dissitribute clothing, tools and food to the Chichimecs in return for their pacification and recognition of the Spanish Crown.
 In addition, he recruited hundreds of Tlaxcaltec families to move and live among the Chichimecs so as to convert them to the Catholic faith and to a sedentary lifestyle by teaching them agricultural methods.

Needless to say, at the end of the 16th century there were very few Spaniards that lived in the vicinity of Tlaltenango.
 In the decade of 1540, probably after the Mixtón War, the towns of the valley were entrusted as encomiendas to a number of Spaniards.
 The town of Tlaltenango was entrusted to Toribio de Bolaños, Tepechitlán to Pedro de Bobadilla, a soldier of Nuño Beltrán de Guzmán, and El Teúl was an encomineda of Juan Delgado.
 It is unlikely that these individuals were able to exercise their rights over the indigenous populations during the 16th century, given that the successive rebellions would have made it difficult.
 However, with the end of war, Spaniards began arriving and settling among the newly pacified indigenous inhabitants of the region.

In 1550, the town of Tlaltenango had 132 houses, in which lived 626 persons.
 By 1561, the tributary population (adult males) reached 379.
 In 1570, the tributary population had reached 1,000 individuals and there were 20 Spaniards living in the town of Tlaltenango.
 The valley had more than 8,000 inhabitants.
 Such a rapid increase in population indicates a great inflow of migrants into the reg
In 1530, the Valley of Tlaltenango was inhabited by the indigenous Caxcans who farmed the land on the river banks and certainly enjoyed the abundance of flora and fauna of the mountain ranges that surrounded the valley.  The meaning of the word Tlaltenango in the Caxcan language (land surrounded by walls) alludes to the mountainous landscape of the valley.
Between these walls, the Sierra del Mixtón to the east and the Sierra de Tepeque to the west, transited Nuño Beltrán de Guzmán and his soldiers, leaving, according to the historian Peter Gerhard, “a path of corpses and destroyed houses and crops, impressing surviving males into service and leaving women and children to starve.”  Frame 56 of the Lienzo de Tlaxcala describes a battle in which the Caxcans of “Tlaltenapa” defended their lands against the Spanish and their Tlaxcaltec allies.
The memories of this first encounter with the Spanish must have tormented the inhabitants of Tlaltenango and its surrounding area.  So great was the anguish that in 1531, from the mountains near El Teúl, they launched an attack against the Spanish who were attempting to build a town named the Town of the Holy Spirit of Guadalajara near what is now Nochistlán.  The Town of Guadalajara was left in ruins and the Spanish had to make another three attempts before the town finally survived in its present location (the Atemajac Valley) where it was built in 1542.
In 1541, the Caxcans took up arms against the Spanish once again, with their Tepehuan, Zacatec and Guachichil allies.  From the Sierra del Mixtón, which is today known as Sierra de Morones, the indigenous allies of the region attacked the Spanish.  The Mixtón War lasted less than two years, but peace was not long-lived.  In 1550, the seeds of war sprouted once again with the great Chichimeca War, a war fought by a great number of Chichimec ethnic groups (Chichimec was a pejorative term used by civilized ethnic groups of the south to describe the nomadic ethnic groups of the north).  This war lasted almost forty years.  While it seems that the residents of the Valley of Tlaltenango did not participate in this rebellion, the region suffered the consequences of war nevertheless due to the chaos all around it.  For having submitted to the Spanish Crown, The Caxcan towns of the area around Tlaltenango suffered attacks from the north launched by their former allies, the Zacatecs.
The war only came to an end when the Viceroy Luís de Velasco decided to purchase peace with the Chichimecs.  As part of the peace offering, the Viceroy used the power of the Royal Treasury to dissitribute clothing, tools and food to the Chichimecs in return for their pacification and recognition of the Spanish Crown.  In addition, he recruited hundreds of Tlaxcaltec families to move and live among the Chichimecs so as to convert them to the Catholic faith and to a sedentary lifestyle by teaching them agricultural methods.
Needless to say, at the end of the 16th century there were very few Spaniards that lived in the vicinity of Tlaltenango.  In the decade of 1540, probably after the Mixtón War, the towns of the valley were entrusted as encomiendas to a number of Spaniards.  The town of Tlaltenango was entrusted to Toribio de Bolaños, Tepechitlán to Pedro de Bobadilla, a soldier of Nuño Beltrán de Guzmán, and El Teúl was an encomineda of Juan Delgado.  It is unlikely that these individuals were able to exercise their rights over the indigenous populations during the 16th century, given that the successive rebellions would have made it difficult.  However, with the end of war, Spaniards began arriving and settling among the newly pacified indigenous inhabitants of the region.
In 1550, the town of Tlaltenango had 132 houses, in which lived 626 persons.  By 1561, the tributary population (adult males) reached 379.  In 1570, the tributary population had reached 1,000 individuals and there were 20 Spaniards living in the town of Tlaltenango.  The valley had more than 8,000 inhabitants.  Such a rapid increase in population indicates a great inflow of migrants into the reg
Tlaltenango de Sánchez Román Municipality