VP-1 was again called upon for operational service as the conflict in Vietnam ramped up.
 On 7 October 1964, the squadron deployed to Marine Corps Air Station Iwakuni, Japan from which it mounted antisubmarine patrols and reported on Communist shipping in the Gulf of Tonkin.
 Closer in, a detachment was deployed to Tan Son Nhut and Da Nang, Vietnam.
 This first deployment to Vietnam was concluded with the squadron's return to Whidbey Island on 1 April 1965.
 A second deployment was made on 13 February 1966, replacing Patrol Squadron 22 at Iwakumi and deploying a detachment of seven aircraft to Tan Son Nhut.
 These aircraft participated in Operation Market Time, a joint United States - South Vietnam effort begun on 11 March 1965, by mounting coastal patrols aimed at stopping supply of equipment and munitions to the North Vietnamese by sea.
 VP-1 was the first patrol squadron to suffer casualties in Vietnam with one person killed and five wounded during an attack on Tan Son Nhut on 13 April 1966.
 Five of the squadron's aircraft were damaged as well during the action.

The squadron's third Vietnam deployment was out of Naval Air Station Sangley Point in Cavite, Philippines with a forward detachment becoming the first to operate full-time from the recently completed Naval Air Facility Cam Ranh in Vietnam.
 This 1967 deployment was followed by another rotation the following year using the same facilities, but in 1970, the squadron's return to the West Pacific was back at Iwakuni and several detachments were supported, including to the previously utilized Cam Ranh and Tan Son Nhut air bases as well as a new detachment to U-Tapao Royal Thai Navy Airfield in Thailand.
 The squadron returned to Sangley Point for its 1971 deployment, but had to move to Naval Air Station Cubi Point, also in the Philippines, as Sangley Point was shut down in May.  VP-1 thus became the first patrol squadron to operate from the new Cubi Point facility.
 The squadron's final Vietnam combat deployment was to Cubi Point in 1972 with a six aircraft detachment at U-Tapao.

In 1980, the squadron deployed to Cubi Point again with a three aircraft detachment at Naval Air Station Diego Garcia in the Indian Ocean.
 While the Vietnam War had ended several years prior, the squadron was heavily involved in search and rescue efforts for Vietnamese boat people.
 The squadron would end up being involved in the rescue of more than 4,000 people, earning its receipt of the Humanitarian Service Medal.
VP-1 was again called upon for operational service as the conflict in Vietnam ramped up.  On 7 October 1964, the squadron deployed to Marine Corps Air Station Iwakuni, Japan from which it mounted antisubmarine patrols and reported on Communist shipping in the Gulf of Tonkin.  Closer in, a detachment was deployed to Tan Son Nhut and Da Nang, Vietnam.  This first deployment to Vietnam was concluded with the squadron's return to Whidbey Island on 1 April 1965.  A second deployment was made on 13 February 1966, replacing Patrol Squadron 22 at Iwakumi and deploying a detachment of seven aircraft to Tan Son Nhut.  These aircraft participated in Operation Market Time, a joint United States - South Vietnam effort begun on 11 March 1965, by mounting coastal patrols aimed at stopping supply of equipment and munitions to the North Vietnamese by sea.  VP-1 was the first patrol squadron to suffer casualties in Vietnam with one person killed and five wounded during an attack on Tan Son Nhut on 13 April 1966.  Five of the squadron's aircraft were damaged as well during the action.
The squadron's third Vietnam deployment was out of Naval Air Station Sangley Point in Cavite, Philippines with a forward detachment becoming the first to operate full-time from the recently completed Naval Air Facility Cam Ranh in Vietnam.  This 1967 deployment was followed by another rotation the following year using the same facilities, but in 1970, the squadron's return to the West Pacific was back at Iwakuni and several detachments were supported, including to the previously utilized Cam Ranh and Tan Son Nhut air bases as well as a new detachment to U-Tapao Royal Thai Navy Airfield in Thailand.  The squadron returned to Sangley Point for its 1971 deployment, but had to move to Naval Air Station Cubi Point, also in the Philippines, as Sangley Point was shut down in May.  VP-1 thus became the first patrol squadron to operate from the new Cubi Point facility.  The squadron's final Vietnam combat deployment was to Cubi Point in 1972 with a six aircraft detachment at U-Tapao.
In 1980, the squadron deployed to Cubi Point again with a three aircraft detachment at Naval Air Station Diego Garcia in the Indian Ocean.  While the Vietnam War had ended several years prior, the squadron was heavily involved in search and rescue efforts for Vietnamese boat people.  The squadron would end up being involved in the rescue of more than 4,000 people, earning its receipt of the Humanitarian Service Medal.
VP-1