Mantia has partnered with musician Melissa Reese on several projects, a composing team dubbed "Brain and Melissa".
In 2010, along with Buckethead, they released the multi-CD sets Kind Regards and Best Regards.
Brain and Melissa composed part of the soundtrack to the video game Infamous 2, for which they were nominated for "Outstanding Achievement in Original Composition" by the Academy of Interactive Arts and Sciences awards.
Other video games the duo worked on include, PlayStation Home, ModNation Racers, Twisted Metal, Fantasia: Music Evolved and Infamous: Second Son (received the nomination Original Dramatic Score, Franchise at the 2014 NAVGTR Awards, shared with Marc Canham and Nathan Johnson).
They also scored the films Detention and Power/Rangers.
They have worked with music video director Joseph Kahn on several television commercials, including NASCAR, SEAT, and Qoros.
In addition, they scored a commercial for Johnnie Walker Blue which featured a computer-generated Bruce Lee.
They also worked on several remixes of songs off of Chinese Democracy for a planned remix album.

The two created a stock music album called "Eclectic Cinema" alongside former Guns N' Roses guitarist Paul Tobias, and Guns N' Roses and Buckethead collaborator Pete Scaturro.
Mantia has also worked with Tobias on several other stock music tracks.

The duo performed at a Houston Rockets halftime show on November 10, 2017, performing remixes of "Sorry" and "If the World" from Chinese Democracy, and a cover of KISS's "Do You Love Me?"
from Destroyer.
Mantia has partnered with musician Melissa Reese on several projects, a composing team dubbed "Brain and Melissa". In 2010, along with Buckethead, they released the multi-CD sets Kind Regards and Best Regards. Brain and Melissa composed part of the soundtrack to the video game Infamous 2, for which they were nominated for "Outstanding Achievement in Original Composition" by the Academy of Interactive Arts and Sciences awards. Other video games the duo worked on include, PlayStation Home, ModNation Racers, Twisted Metal, Fantasia: Music Evolved and Infamous: Second Son (received the nomination Original Dramatic Score, Franchise at the 2014 NAVGTR Awards, shared with Marc Canham and Nathan Johnson). They also scored the films Detention and Power/Rangers. They have worked with music video director Joseph Kahn on several television commercials, including NASCAR, SEAT, and Qoros. In addition, they scored a commercial for Johnnie Walker Blue which featured a computer-generated Bruce Lee. They also worked on several remixes of songs off of Chinese Democracy for a planned remix album.
The two created a stock music album called "Eclectic Cinema" alongside former Guns N' Roses guitarist Paul Tobias, and Guns N' Roses and Buckethead collaborator Pete Scaturro. Mantia has also worked with Tobias on several other stock music tracks.
The duo performed at a Houston Rockets halftime show on November 10, 2017, performing remixes of "Sorry" and "If the World" from Chinese Democracy, and a cover of KISS's "Do You Love Me?" from Destroyer.
Bryan Mantia