Assis is the headquarters of the Departamento de Estradas e Rodagens de São Paulo (Departament of Roads of São Paulo), being the 7th Regional Division.
It is responsible for managing state roads of Middle Paranapanema and part of the Marília's Mesoregion and Ourinhos's Microregion.

Avenida/Rodovia Benedito Pires (Benedito Pires Highway/Avenue) - Connects Assis to Cândido Mota.
Four-lane highway.

SP-270 - Rodovia Raposo Tavares (Raposo Tavares Highway) - Connects Assis to Ourinhos, Presidente Prudente, São Paulo and others.
From Ourinhos to Presidente Prudente is a freeway highway.

SP-284 - Rodovia Manilo Gobbi (Manilo Gobbi Highway) - Connects Assis to Paraguaçu Paulista
SP-333 - Rodovia Rachid Rayes (Rachid Rayes Highway) - Connects Assis to Marília and Bauru
SP-333 - Rodovia Miguel Jubran (Miguel Jubran Highway) - Connects Assis to Tarumã, Florínia and Paraná State (old Assis - Londrina Highway).
Assis to Tarumã is a freeway highway.

The city is served by Assis Airport.
Assis is the headquarters of the Departamento de Estradas e Rodagens de São Paulo (Departament of Roads of São Paulo), being the 7th Regional Division. It is responsible for managing state roads of Middle Paranapanema and part of the Marília's Mesoregion and Ourinhos's Microregion.
Avenida/Rodovia Benedito Pires (Benedito Pires Highway/Avenue) - Connects Assis to Cândido Mota. Four-lane highway.
SP-270 - Rodovia Raposo Tavares (Raposo Tavares Highway) - Connects Assis to Ourinhos, Presidente Prudente, São Paulo and others. From Ourinhos to Presidente Prudente is a freeway highway.
SP-284 - Rodovia Manilo Gobbi (Manilo Gobbi Highway) - Connects Assis to Paraguaçu Paulista
SP-333 - Rodovia Rachid Rayes (Rachid Rayes Highway) - Connects Assis to Marília and Bauru
SP-333 - Rodovia Miguel Jubran (Miguel Jubran Highway) - Connects Assis to Tarumã, Florínia and Paraná State (old Assis - Londrina Highway). Assis to Tarumã is a freeway highway.
The city is served by Assis Airport.
Assis