On September 17, 2017, in Week 2, Fluellen had the first three rushes of his career, which went for 18 yards, in a 37–16 victory over the Jacksonville Jaguars.
Overall, he finished the 2017 season with four carries for 21 rushing yards.
The Titans finished second in the AFC South with a 9–7 record and made the playoffs as a Wild Card team.
In the Wild Card Round against the Kansas City Chiefs, Fluellen returned a kickoff for 12 yards right before halftime.
The Titans won 22-21.
On September 17, 2017, in Week 2, Fluellen had the first three rushes of his career, which went for 18 yards, in a 37–16 victory over the Jacksonville Jaguars. Overall, he finished the 2017 season with four carries for 21 rushing yards. The Titans finished second in the AFC South with a 9–7 record and made the playoffs as a Wild Card team. In the Wild Card Round against the Kansas City Chiefs, Fluellen returned a kickoff for 12 yards right before halftime. The Titans won 22-21.
David Fluellen