While Lowery was working with Loser, he also began to work with cult rock artist and movie director Rob Zombie.
Meeting at the Camp Freddy benefit gig, Lowery and Zombie hit it off immediately and Rob asked Lowery to play with him at Ozzfest 2005.

"I'm totally ecstatic about having the opportunity to play with Rob on Ozzfest!
He has been one of my favorite artists for the longest time.
I had the opportunity to play with him a few weeks back and never thought that I would have the chance to share the stage with him playing the Zombie songs we all know and love!"

It was reported that Zombie was looking to quit the music industry to concentrate on his movie career until he began to work with Lowery.

"Camp Freddy asked me to do this benefit, just to play one song, at the Arrowhead Pond (in Anaheim, California) for this tsunami relief thing.
And John was there, and we played one song, 'Thunderkiss,' and it kicked ass and he's a supercool guy and I was like, 'this is perfect.'
John said, 'Do you need a guitar player for Ozzfest?'
I said, 'Yes.'
He said, 'I wanna do it,' I said, 'Perfect, done.'"
-Rob Zombie on John 5
Lowery worked on Rob Zombie's 2006 album Educated Horses, co-writing eight out of eleven tracks with Zombie.
When he left Loser, Lowery took up the role of Rob Zombie guitarist as a permanent gig. "
Rob is the best I have worked with.
He's great.
We have a great time on stage together.
It has been the single greatest experience I have had working with someone, hands down."
John is also the guitarist on Rob's latest albums, Hellbilly Deluxe 2, released February 2, 2010, Venomous Rat Regeneration Vendor, released April 23, 2013, and The Electric Warlock Acid Witch Satanic Orgy Celebration Dispenser, released April 29, 2016.

In early 2011, Lowery was joined by fellow ex-Marilyn Manson bandmate, Ginger Fish, as a member of Rob Zombie's band.
Zombie/Slipknot drummer Joey Jordison was in Europe with his band Murderdolls, leaving Zombie without a drummer for some shows during the American leg of their tour.
Lowery asked Fish to fill in as drummer.
In April 2011, Fish was announced as the new and permanent drummer.

In October 2011, Zombie confirmed by his Facebook  account that Lowery would be scoring the soundtrack for Rob Zombie's latest movie, The Lords of Salem.
This was also confirmed on the official John 5 website.
While Lowery was working with Loser, he also began to work with cult rock artist and movie director Rob Zombie. Meeting at the Camp Freddy benefit gig, Lowery and Zombie hit it off immediately and Rob asked Lowery to play with him at Ozzfest 2005.
"I'm totally ecstatic about having the opportunity to play with Rob on Ozzfest! He has been one of my favorite artists for the longest time. I had the opportunity to play with him a few weeks back and never thought that I would have the chance to share the stage with him playing the Zombie songs we all know and love!"
It was reported that Zombie was looking to quit the music industry to concentrate on his movie career until he began to work with Lowery.
"Camp Freddy asked me to do this benefit, just to play one song, at the Arrowhead Pond (in Anaheim, California) for this tsunami relief thing. And John was there, and we played one song, 'Thunderkiss,' and it kicked ass and he's a supercool guy and I was like, 'this is perfect.' John said, 'Do you need a guitar player for Ozzfest?' I said, 'Yes.' He said, 'I wanna do it,' I said, 'Perfect, done.'" -Rob Zombie on John 5
Lowery worked on Rob Zombie's 2006 album Educated Horses, co-writing eight out of eleven tracks with Zombie. When he left Loser, Lowery took up the role of Rob Zombie guitarist as a permanent gig. "Rob is the best I have worked with. He's great. We have a great time on stage together. It has been the single greatest experience I have had working with someone, hands down." John is also the guitarist on Rob's latest albums, Hellbilly Deluxe 2, released February 2, 2010, Venomous Rat Regeneration Vendor, released April 23, 2013, and The Electric Warlock Acid Witch Satanic Orgy Celebration Dispenser, released April 29, 2016.
In early 2011, Lowery was joined by fellow ex-Marilyn Manson bandmate, Ginger Fish, as a member of Rob Zombie's band. Zombie/Slipknot drummer Joey Jordison was in Europe with his band Murderdolls, leaving Zombie without a drummer for some shows during the American leg of their tour. Lowery asked Fish to fill in as drummer. In April 2011, Fish was announced as the new and permanent drummer.
In October 2011, Zombie confirmed by his Facebook  account that Lowery would be scoring the soundtrack for Rob Zombie's latest movie, The Lords of Salem. This was also confirmed on the official John 5 website.
John 5 (guitarist)