Henry split carries with offseason acquisition Dion Lewis and run-oriented quarterback Marcus Mariota for most of the 2018 season.
During Week 2, Henry recorded an eight-yard pass completion, the first of his career, to wide receiver Taywan Taylor in the Titans' 20–17 victory over the Houston Texans.
He also had 18 carries in that game and the next against the Jacksonville Jaguars, but was used much less frequently through the middle of the season.

From Weeks 4-13, Henry averaged nine carries for only 37 yards per game, and never rushed for over 60 yards.
This all changed in Week 14 against the Jaguars.
In the second quarter, Henry had a 99-yard touchdown run, fending off three tacklers, tying him with Tony Dorsett for the longest NFL touchdown run.
He finished the game with four rushing touchdowns and 238 rushing yards on 17 carries, breaking Chris Johnson's franchise record of 228 yards in 2009.
He also became the ninth player in NFL history to record a 200+ yard and 4+ touchdown game, and the first to do so on fewer than 22 carries.
His 238 rushing yards were the most by any player for a single game for the 2018 season.
Henry was named the AFC Offensive Player of the Week due to his spectacular performance.
During Week 15, the Titans went on the road to face the New York Giants.
In a cold and rainy game, Henry led the NFL in rushing for the second consecutive week with 170 yards and two touchdowns on a career-high 33 carries, along with a one-yard reception and six-yard pass completion in the 17–0 shutout.
In Weeks 16 and 17, he combined for 177 rushing yards and a touchdown in the two games against the Washington Redskins and Indianapolis Colts.
He was later named the AFC Offensive Player of the Month for December.

Henry finished the 2018 season with 1,059 rushing yards, 12 rushing touchdowns, and 15 receptions.
After the season, he was ranked 99th on the NFL Top 100 Players of 2019.
Henry split carries with offseason acquisition Dion Lewis and run-oriented quarterback Marcus Mariota for most of the 2018 season. During Week 2, Henry recorded an eight-yard pass completion, the first of his career, to wide receiver Taywan Taylor in the Titans' 20–17 victory over the Houston Texans. He also had 18 carries in that game and the next against the Jacksonville Jaguars, but was used much less frequently through the middle of the season.
From Weeks 4-13, Henry averaged nine carries for only 37 yards per game, and never rushed for over 60 yards. This all changed in Week 14 against the Jaguars. In the second quarter, Henry had a 99-yard touchdown run, fending off three tacklers, tying him with Tony Dorsett for the longest NFL touchdown run. He finished the game with four rushing touchdowns and 238 rushing yards on 17 carries, breaking Chris Johnson's franchise record of 228 yards in 2009. He also became the ninth player in NFL history to record a 200+ yard and 4+ touchdown game, and the first to do so on fewer than 22 carries. His 238 rushing yards were the most by any player for a single game for the 2018 season. Henry was named the AFC Offensive Player of the Week due to his spectacular performance. During Week 15, the Titans went on the road to face the New York Giants. In a cold and rainy game, Henry led the NFL in rushing for the second consecutive week with 170 yards and two touchdowns on a career-high 33 carries, along with a one-yard reception and six-yard pass completion in the 17–0 shutout. In Weeks 16 and 17, he combined for 177 rushing yards and a touchdown in the two games against the Washington Redskins and Indianapolis Colts. He was later named the AFC Offensive Player of the Month for December.
Henry finished the 2018 season with 1,059 rushing yards, 12 rushing touchdowns, and 15 receptions. After the season, he was ranked 99th on the NFL Top 100 Players of 2019.
Derrick Henry