After several years of living together, Rochussen married Anna Sara Velsberg in Amsterdam on 14 December 1831; they had nine children together before Velsberg's death on 18 June 1841.
His second marriage was to a Creole woman, Elisabeth Charlotta Vincent, on 2 September 1848 while he was in Batavia; the couple produced two daughters, with Vincent dying in childbirth for the second.

Rochussen's son Willem Frederik Rochussen went on to be Minister of Foreign Affairs from 15 September 1881 until 23 April 1883.
He also had several sons-in-law and nephews who entered politics, such as Jacob van Zuylen van Nijevelt, Frederik s'Jacob (future governor of the Dutch East Indies), and representative GA de Raadt.
His grandson, Herman Adriaan van Karnebeek, became mayor of The Hague, Minister of Foreign Affairs, and later President of the League of Nations from 1921 to 1922.
After several years of living together, Rochussen married Anna Sara Velsberg in Amsterdam on 14 December 1831; they had nine children together before Velsberg's death on 18 June 1841. His second marriage was to a Creole woman, Elisabeth Charlotta Vincent, on 2 September 1848 while he was in Batavia; the couple produced two daughters, with Vincent dying in childbirth for the second.
Rochussen's son Willem Frederik Rochussen went on to be Minister of Foreign Affairs from 15 September 1881 until 23 April 1883. He also had several sons-in-law and nephews who entered politics, such as Jacob van Zuylen van Nijevelt, Frederik s'Jacob (future governor of the Dutch East Indies), and representative GA de Raadt. His grandson, Herman Adriaan van Karnebeek, became mayor of The Hague, Minister of Foreign Affairs, and later President of the League of Nations from 1921 to 1922.
Jan Jacob Rochussen