Burdisso starred in the Argentina under-20 team along with Javier Saviola and Maxi Rodríguez.
All three won the 2001 FIFA World Youth Championship together.

On 15 May 2006, Burdisso was named as a squad member for the 2006 FIFA World Cup by his former U-20 coach José Pekerman, going on to play in all three group matches.
He also played for Argentina in the Copa América 2007, where the team went on to reach the final.

On 4 June 2008, Burdisso scored his second goal for Argentina during a friendly against Mexico in San Diego, California.
Burdisso was selected to the Argentina squad for the 2010 World Cup by manager Diego Maradona and for the Copa América 2011 by manager Sergio Batista.

On 15 November 2011, Burdisso injured his left knee during a World Cup qualifying match against Colombia.
During a disputed ball with James Rodríguez, Burdisso partially tore his left knee ligaments, with initial assessments predicting a recovery period of six-to-eight months.
Burdisso starred in the Argentina under-20 team along with Javier Saviola and Maxi Rodríguez. All three won the 2001 FIFA World Youth Championship together.
On 15 May 2006, Burdisso was named as a squad member for the 2006 FIFA World Cup by his former U-20 coach José Pekerman, going on to play in all three group matches. He also played for Argentina in the Copa América 2007, where the team went on to reach the final.
On 4 June 2008, Burdisso scored his second goal for Argentina during a friendly against Mexico in San Diego, California. Burdisso was selected to the Argentina squad for the 2010 World Cup by manager Diego Maradona and for the Copa América 2011 by manager Sergio Batista.
On 15 November 2011, Burdisso injured his left knee during a World Cup qualifying match against Colombia. During a disputed ball with James Rodríguez, Burdisso partially tore his left knee ligaments, with initial assessments predicting a recovery period of six-to-eight months.
Nicolás Burdisso