Following the September 11, 2001 attacks, the Blue Knights prepared for immediate departure.
The 26th MEU set sail September 20.
 The MEU transited to a position off the coast of Pakistan to begin combat operations in support of Operation Enduring Freedom.
HMM-365(REIN), in concert with HMM-163(REIN), launched 6 CH-53Es to secure Camp Rhino, nearly 800 nautical miles (1,500 km) inland.
After securing both Camp Rhino and Kandahar Airport deep in Afghanistan, the Blue Knights supported coalition forces conducting raids against the Taliban from December 2001 to February 2002.
In March, the ARG transited to the Red Sea for a potential NEO in Yemen and to support Vice President Dick Cheney’s visit to the region.

In January 2003, the Blue Knights prepared for deployment to Ali Al Salem Airbase, Kuwait in support of Operation Iraqi Freedom (OIF).
 OIF began on March 20, with HMM-365 leading the TRAP Team effort for the initial heliborne raids on the crucial Al Faw Peninsula.
From March 20 until May 1, the squadron provided CASEVAC and assault support to I Marine Expeditionary Force (I MEF), the 24th MEU, the 15th MEU, Task Force Tarawa, and United Nations forces.
 Blue Knight crews flew multiple raids and recon inserts as ground forces maneuvered north towards Baghdad.
Due to the expeditious nature of I MEF's battle rhythm, section detachments were configured into combat crews and pushed forward with coalition forces in order to provide 24-hour support.
Blue Knight aircrews flew 200 to 300-mile (500 km) missions across the Kuwaiti border, into Iraq, to conduct relief operations with other sections for up to a week at a time.
The squadron supported I MEF operations from Ali Al Salem until mid-April when it re-deployed itself in a single day to Jalibah FOB, Iraq where it rejoined MAG-29.
The squadron conducted flight operations from Iraq until May 10, when the squadron embarked aboard USS Kearsarge.
After supporting the President's visit to Egypt and Jordan, the USS Kearsarge transited to Liberia for possible NEO operations.
The Blue Knights returned to New River on June 28, 2003.

On August 7, 2004, HMM-365's main body departed New River, NC for Al Asad Air Base, Iraq.
On August 21, the squadron assumed the assault support mission from HMM-261.

On November 25, the Blue Knights flew the Secretary of the Navy, the honorable Gordon R. England.
On the 13th and 14 December the squadron flew the Commandant of the Marine Corps, General Michael Hagee, to Al Taqaddum and Fallujah.
On February 23, 2005, HMM-365 returned to CONUS after flying more than 3,961 combat hours, 2,404 sorties, 11,162 passengers, and 748,496 pounds of cargo without the loss of aircraft or personnel.

In August 2005, in the wake of the devastation caused by Hurricane Katrina, the Blue Knights dispatched two aircraft and personnel to the Gulf Coast of the United States to conduct search-and-rescue and disaster relief operations in support of JTF Katrina.
 Later that year on November 2, 2005, the squadron had the first CH-46E Sea Knight to be retired and stored in the Boneyard at Davis-Monthan Air Force Base some 41 years after the first CH-46 entered the fleet.

In May 2006, the squadron deployed aboard the USS Iwo Jima as the ACE for the 24th Marine Expeditionary Unit.
While conducting training operations in Jordan, the squadron was ordered to the coast of Beirut for Non-Combatant Evacuation operations at the American Embassy in Beirut.
Also during this deployment, the squadron conducted training in Kuwait for two weeks.
Squadron aircraft also supported operations in the Horn of Africa.

In April 2008, HMM-365(REIN) deployed as the aviation combat element of the 24th MEU.
 The MEU was subsequently sent into Afghanistan as part of Operation Enduring Freedom where their aircraft have been spread out and based out of Kandahar Airfield and Camps Bastion and Dwyer which are over 100 miles away.
During the course of this deployment they have been tasked with supporting the MEU and also the International Security Assistance Force (ISAF) and local Afghan forces.
 They logged o
Following the September 11, 2001 attacks, the Blue Knights prepared for immediate departure. The 26th MEU set sail September 20.  The MEU transited to a position off the coast of Pakistan to begin combat operations in support of Operation Enduring Freedom. HMM-365(REIN), in concert with HMM-163(REIN), launched 6 CH-53Es to secure Camp Rhino, nearly 800 nautical miles (1,500 km) inland. After securing both Camp Rhino and Kandahar Airport deep in Afghanistan, the Blue Knights supported coalition forces conducting raids against the Taliban from December 2001 to February 2002. In March, the ARG transited to the Red Sea for a potential NEO in Yemen and to support Vice President Dick Cheney’s visit to the region.
In January 2003, the Blue Knights prepared for deployment to Ali Al Salem Airbase, Kuwait in support of Operation Iraqi Freedom (OIF).  OIF began on March 20, with HMM-365 leading the TRAP Team effort for the initial heliborne raids on the crucial Al Faw Peninsula. From March 20 until May 1, the squadron provided CASEVAC and assault support to I Marine Expeditionary Force (I MEF), the 24th MEU, the 15th MEU, Task Force Tarawa, and United Nations forces.  Blue Knight crews flew multiple raids and recon inserts as ground forces maneuvered north towards Baghdad. Due to the expeditious nature of I MEF's battle rhythm, section detachments were configured into combat crews and pushed forward with coalition forces in order to provide 24-hour support. Blue Knight aircrews flew 200 to 300-mile (500 km) missions across the Kuwaiti border, into Iraq, to conduct relief operations with other sections for up to a week at a time. The squadron supported I MEF operations from Ali Al Salem until mid-April when it re-deployed itself in a single day to Jalibah FOB, Iraq where it rejoined MAG-29. The squadron conducted flight operations from Iraq until May 10, when the squadron embarked aboard USS Kearsarge. After supporting the President's visit to Egypt and Jordan, the USS Kearsarge transited to Liberia for possible NEO operations. The Blue Knights returned to New River on June 28, 2003.
On August 7, 2004, HMM-365's main body departed New River, NC for Al Asad Air Base, Iraq. On August 21, the squadron assumed the assault support mission from HMM-261.
On November 25, the Blue Knights flew the Secretary of the Navy, the honorable Gordon R. England. On the 13th and 14 December the squadron flew the Commandant of the Marine Corps, General Michael Hagee, to Al Taqaddum and Fallujah. On February 23, 2005, HMM-365 returned to CONUS after flying more than 3,961 combat hours, 2,404 sorties, 11,162 passengers, and 748,496 pounds of cargo without the loss of aircraft or personnel.
In August 2005, in the wake of the devastation caused by Hurricane Katrina, the Blue Knights dispatched two aircraft and personnel to the Gulf Coast of the United States to conduct search-and-rescue and disaster relief operations in support of JTF Katrina.  Later that year on November 2, 2005, the squadron had the first CH-46E Sea Knight to be retired and stored in the Boneyard at Davis-Monthan Air Force Base some 41 years after the first CH-46 entered the fleet.
In May 2006, the squadron deployed aboard the USS Iwo Jima as the ACE for the 24th Marine Expeditionary Unit. While conducting training operations in Jordan, the squadron was ordered to the coast of Beirut for Non-Combatant Evacuation operations at the American Embassy in Beirut. Also during this deployment, the squadron conducted training in Kuwait for two weeks. Squadron aircraft also supported operations in the Horn of Africa.
In April 2008, HMM-365(REIN) deployed as the aviation combat element of the 24th MEU.  The MEU was subsequently sent into Afghanistan as part of Operation Enduring Freedom where their aircraft have been spread out and based out of Kandahar Airfield and Camps Bastion and Dwyer which are over 100 miles away. During the course of this deployment they have been tasked with supporting the MEU and also the International Security Assistance Force (ISAF) and local Afghan forces.  They logged o
VMM-365