The Embraer E175 made its United States domestic debut when the first aircraft was delivered to Republic Airline in March 2007.
Total orders were for 36 aircraft, which were operated in an 80-seat configuration under the US Airways Express brand name.

In July 2010, Republic ordered a further 24 Embraer E190 aircraft.

In May 2012, Republic Airline agreed to fly the 28 Bombardier Q400s for United Express that bankrupt Pinnacle Airlines planned to return to its lessors.
The Q400 fleet was retired in 2017.

Republic Airways Holdings signed a three-year contract in October 2012 with Caesars Entertainment Corporation where its Republic Airline subsidiary would operate five Embraer E190 aircraft to provide more than 1,500 charter flights annually for Caesars.
Service began in January 2013.
This contract ended in August 2015 and all E190 aircraft were sold or returned to the lease holders.

In January 2013, Republic Airways Holdings reached a capacity purchase agreement with American Airlines to operate 47 Embraer E175 airplanes under the American Eagle brand beginning in mid-2013.
The regional jets would be deployed out of American's Chicago hub.
In addition, Republic would have options to purchase an additional 47 Embraer aircraft beginning in 2015.
Republic took first delivery of the E175 jets in July 2013 and service began August 1, 2013, from Chicago to New Orleans, Pittsburgh and Albuquerque.
Republic began using Miami as an American Eagle hub in October 2014 and in New York-JFK in May 2015.

In late 2015, it was announced Republic Airline achieved approval from the FAA for Extended Overwater Operations (EOW), which allows Republic to operate up to 162 nautical miles from shore.
As of January 31, 2017, only Republic E175 aircraft operating for American Airlines are equipped to operate as an EOW aircraft.
American Airlines uses Republic to operate aircraft out of Miami International Airport to various Caribbean and Central American destinations, including the Bahamas, Mexico, Panama, Belize, Honduras, Costa Rica, Turks & Caicos, Cuba, Guadeloupe, and the French West Indies.

In late 2016 it was announced, due to the impending merger with Shuttle America, that the 80-seat Embraer E175s operated for American Eagle (previously US Airways Express) would have the last row of seats removed (4 in total) to conform with Delta's scope clause, which limits all regional jets to a maximum of 76 seats.
These aircraft will eventually be retrofitted to American's standard Embraer 175 layout.

On January 31, 2017, all existing aircraft operating under the Shuttle America operating certificate were transferred to the Republic Airline Inc. operating certificate, thus ceasing operations for Shuttle America, and completing the merger process of both subsidiaries.
The move made Republic the largest operator of Embraer E170 and Embraer E175 aircraft in the world.

On December 20, 2018, Republic Airline announced that it had finalized a firm order for 100 Embraer E175 aircraft, stating that deliveries for the new aircraft would start in the second half of 2020 
In October 2019, Republic received the first of 30 E175s to be transferred from Compass Airlines upon the cancellation of their contract with Delta.
The Embraer E175 made its United States domestic debut when the first aircraft was delivered to Republic Airline in March 2007. Total orders were for 36 aircraft, which were operated in an 80-seat configuration under the US Airways Express brand name.
In July 2010, Republic ordered a further 24 Embraer E190 aircraft.
In May 2012, Republic Airline agreed to fly the 28 Bombardier Q400s for United Express that bankrupt Pinnacle Airlines planned to return to its lessors. The Q400 fleet was retired in 2017.
Republic Airways Holdings signed a three-year contract in October 2012 with Caesars Entertainment Corporation where its Republic Airline subsidiary would operate five Embraer E190 aircraft to provide more than 1,500 charter flights annually for Caesars. Service began in January 2013. This contract ended in August 2015 and all E190 aircraft were sold or returned to the lease holders.
In January 2013, Republic Airways Holdings reached a capacity purchase agreement with American Airlines to operate 47 Embraer E175 airplanes under the American Eagle brand beginning in mid-2013. The regional jets would be deployed out of American's Chicago hub. In addition, Republic would have options to purchase an additional 47 Embraer aircraft beginning in 2015. Republic took first delivery of the E175 jets in July 2013 and service began August 1, 2013, from Chicago to New Orleans, Pittsburgh and Albuquerque. Republic began using Miami as an American Eagle hub in October 2014 and in New York-JFK in May 2015.
In late 2015, it was announced Republic Airline achieved approval from the FAA for Extended Overwater Operations (EOW), which allows Republic to operate up to 162 nautical miles from shore. As of January 31, 2017, only Republic E175 aircraft operating for American Airlines are equipped to operate as an EOW aircraft. American Airlines uses Republic to operate aircraft out of Miami International Airport to various Caribbean and Central American destinations, including the Bahamas, Mexico, Panama, Belize, Honduras, Costa Rica, Turks & Caicos, Cuba, Guadeloupe, and the French West Indies.
In late 2016 it was announced, due to the impending merger with Shuttle America, that the 80-seat Embraer E175s operated for American Eagle (previously US Airways Express) would have the last row of seats removed (4 in total) to conform with Delta's scope clause, which limits all regional jets to a maximum of 76 seats. These aircraft will eventually be retrofitted to American's standard Embraer 175 layout.
On January 31, 2017, all existing aircraft operating under the Shuttle America operating certificate were transferred to the Republic Airline Inc. operating certificate, thus ceasing operations for Shuttle America, and completing the merger process of both subsidiaries. The move made Republic the largest operator of Embraer E170 and Embraer E175 aircraft in the world.
On December 20, 2018, Republic Airline announced that it had finalized a firm order for 100 Embraer E175 aircraft, stating that deliveries for the new aircraft would start in the second half of 2020 
In October 2019, Republic received the first of 30 E175s to be transferred from Compass Airlines upon the cancellation of their contract with Delta.
Republic Airways