The church is likely to have contained an organ before the reformation.
The first post-Reformation organ was installed in 1720 and survived until 1817.
A new organ by Flight and Robson was then installed.

The basis of the current instrument is a pipe organ which was built by Father Henry Willis for the Great Exhibition in 1851 and installed and opened by him in Totnes on Sunday 11 August 1861.
 It has since had subsequent restorations and modifications and now comprises 3 manuals and pedals with 33 speaking stops.
A specification of the organ can be found in the National Pipe Organ Register.
The church is likely to have contained an organ before the reformation. The first post-Reformation organ was installed in 1720 and survived until 1817. A new organ by Flight and Robson was then installed. 
The basis of the current instrument is a pipe organ which was built by Father Henry Willis for the Great Exhibition in 1851 and installed and opened by him in Totnes on Sunday 11 August 1861.  It has since had subsequent restorations and modifications and now comprises 3 manuals and pedals with 33 speaking stops. A specification of the organ can be found in the National Pipe Organ Register.
St Mary's Church, Totnes