On August 3, 2010, NBC Sports reported the confirmation of Favre returning to the Vikings but saying that the 2010 season would be his final season.
An announcement was given on August 17, 2010 confirming his return to the team.
That season, Favre achieved two milestones.
He threw for his 500th touchdown and 70,000th yard against the New York Jets.
On November 7, 2010, in a game against the Arizona Cardinals, Favre threw for a career-high 446 yards while rallying the Vikings from a 14-point fourth quarter deficit to win in overtime.
On December 5, 2010, in a game against the Buffalo Bills, Favre was hit by Bills linebacker Arthur Moats while making a throw, causing him to sustain a sprain of the AC joint in his right shoulder.
Favre missed the rest of the game and was replaced by Tarvaris Jackson, who helped lead the Vikings to victory despite throwing three interceptions.

On December 13, 2010, due to his sprained shoulder, Favre was marked inactive for the game against the New York Giants ending his consecutive regular season start streak at 297.
Favre started a total of 321 games including post-season appearances.
On December 20, 2010 while playing the Chicago Bears outside at TCF Bank Stadium due to the collapse of the roof of the Hubert H. Humphrey Metrodome, Favre sustained a concussion after being sacked by Bears defensive end Corey Wootton.
As a rattled Favre was helped to his feet by Vikings' athletic trainer Eric Sugarman, he asked, "Suge, what are the Bears doing here?".
This would be his final appearance in an NFL game.

On January 2, 2011, Favre was unable to play against the Detroit Lions in the final game of the regular NFL season due to his inability to pass NFL-mandated post-concussion tests.
In a press conference immediately following the game, Favre announced his intention to retire from professional football.
On January 17, 2011, Favre officially filed his retirement papers with the NFL.
On August 3, 2010, NBC Sports reported the confirmation of Favre returning to the Vikings but saying that the 2010 season would be his final season. An announcement was given on August 17, 2010 confirming his return to the team. That season, Favre achieved two milestones. He threw for his 500th touchdown and 70,000th yard against the New York Jets. On November 7, 2010, in a game against the Arizona Cardinals, Favre threw for a career-high 446 yards while rallying the Vikings from a 14-point fourth quarter deficit to win in overtime. On December 5, 2010, in a game against the Buffalo Bills, Favre was hit by Bills linebacker Arthur Moats while making a throw, causing him to sustain a sprain of the AC joint in his right shoulder. Favre missed the rest of the game and was replaced by Tarvaris Jackson, who helped lead the Vikings to victory despite throwing three interceptions.
On December 13, 2010, due to his sprained shoulder, Favre was marked inactive for the game against the New York Giants ending his consecutive regular season start streak at 297. Favre started a total of 321 games including post-season appearances. On December 20, 2010 while playing the Chicago Bears outside at TCF Bank Stadium due to the collapse of the roof of the Hubert H. Humphrey Metrodome, Favre sustained a concussion after being sacked by Bears defensive end Corey Wootton. As a rattled Favre was helped to his feet by Vikings' athletic trainer Eric Sugarman, he asked, "Suge, what are the Bears doing here?". This would be his final appearance in an NFL game.
On January 2, 2011, Favre was unable to play against the Detroit Lions in the final game of the regular NFL season due to his inability to pass NFL-mandated post-concussion tests. In a press conference immediately following the game, Favre announced his intention to retire from professional football. On January 17, 2011, Favre officially filed his retirement papers with the NFL.
Brett Favre