Youzhny played his first Davis Cup match in the World Group first round against Belgium in a dead rubber.
He defeated Olivier Rochus in the fourth match.
Youzhny would go on to lose four matches in a row.
At the 2002 World Group final, Youzhny played the deciding match against Paul-Henri Mathieu and came back from two sets down to win.
In 2003, in Russia's first round match against Belarus, Youzhny played the fifth and decisive match and lost to Vladimir Voltchkov.
In the 2006 World Group Youzhny participated in the first round, quarterfinals and in the semifinals, but did not play in the final against Argentina.
However, he did participate in the 2007 final against the United States, but he lost in the second match to James Blake in four sets.
The defeat gave the United States a 2–0 lead over Russia, with the United States winning the final 4–1.
At the 2008 World Group Youzhny only participated in the first round against Serbia, winning his singles match against Nenad Zimonjić.
In the third match he partnered with Dmitry Tursunov against Novak Djokovic and Nenad Zimonjić but lost.
However, despite his doubles loss, Russia advanced and won 3–2.

Russia, which was world number one, was heavily favored in their match against Israel.
The matches were hosted by Israel in the World Group quarterfinal tie in July 2009, on indoor hard courts at the Nokia Arena in Tel Aviv.
Israel beat Russia in each of their first three matches, thereby winning the tie.
world number 210 Harel Levy first beat world number twenty-four Igor Andreev, while world number thirty-three Dudi Sela followed by beating Youzhny in four sets. "
This is a bit of a surprise", Youzhny said.
He said he was very disappointed, and added: "I began very well, but after I took the first set, my luck fell away."
The next day Israelis Andy Ram and Jonathan Erlich beat Safin and doubles specialist Igor Kunitsyn.
 Israel defeated Russia 4–1 for the win.

Youzhny resigned from the Russian Davis Cup team in February 2011, stating, "I think the time has come for me step aside and give younger players a chance".
He added, "Now, I want to devote more time to my family and concentrate on individual tournaments".
However, he competed at the 2011 Davis Cup tie with Brazil, stating that "We're in a tough situation right now and I thought it was my duty to help the team.
Therefore, I've made myself available for that tie."
Youzhny won both of his rubbers, the first against Ricardo Mello, while he took over five hours to defeat Thomaz Bellucci, 14–12 in the fifth set.
In his last Davis Cup match so far, in 2012, Youzhny partnered with Nikolay Davydenko to beat Austria doubles team Oliver Marach and Alexander Peya.
Youzhny played his first Davis Cup match in the World Group first round against Belgium in a dead rubber. He defeated Olivier Rochus in the fourth match. Youzhny would go on to lose four matches in a row. At the 2002 World Group final, Youzhny played the deciding match against Paul-Henri Mathieu and came back from two sets down to win. In 2003, in Russia's first round match against Belarus, Youzhny played the fifth and decisive match and lost to Vladimir Voltchkov. In the 2006 World Group Youzhny participated in the first round, quarterfinals and in the semifinals, but did not play in the final against Argentina. However, he did participate in the 2007 final against the United States, but he lost in the second match to James Blake in four sets. The defeat gave the United States a 2–0 lead over Russia, with the United States winning the final 4–1. At the 2008 World Group Youzhny only participated in the first round against Serbia, winning his singles match against Nenad Zimonjić. In the third match he partnered with Dmitry Tursunov against Novak Djokovic and Nenad Zimonjić but lost. However, despite his doubles loss, Russia advanced and won 3–2.
Russia, which was world number one, was heavily favored in their match against Israel. The matches were hosted by Israel in the World Group quarterfinal tie in July 2009, on indoor hard courts at the Nokia Arena in Tel Aviv. Israel beat Russia in each of their first three matches, thereby winning the tie. world number 210 Harel Levy first beat world number twenty-four Igor Andreev, while world number thirty-three Dudi Sela followed by beating Youzhny in four sets. "This is a bit of a surprise", Youzhny said. He said he was very disappointed, and added: "I began very well, but after I took the first set, my luck fell away." The next day Israelis Andy Ram and Jonathan Erlich beat Safin and doubles specialist Igor Kunitsyn.  Israel defeated Russia 4–1 for the win.
Youzhny resigned from the Russian Davis Cup team in February 2011, stating, "I think the time has come for me step aside and give younger players a chance". He added, "Now, I want to devote more time to my family and concentrate on individual tournaments". However, he competed at the 2011 Davis Cup tie with Brazil, stating that "We're in a tough situation right now and I thought it was my duty to help the team. Therefore, I've made myself available for that tie." Youzhny won both of his rubbers, the first against Ricardo Mello, while he took over five hours to defeat Thomaz Bellucci, 14–12 in the fifth set. In his last Davis Cup match so far, in 2012, Youzhny partnered with Nikolay Davydenko to beat Austria doubles team Oliver Marach and Alexander Peya.
Mikhail Youzhny