Born in Prospect Park, New Jersey, he moved with his family to Midland Park, New Jersey in 1918.
 He had an inauspicious start to his professional baseball career.
He was signed by the Brooklyn Dodgers as an amateur free agent in 1933 and assigned to the Dayton Ducks.
Dayton then sold his contract to a Boston Bees minor league affiliate, the Scranton Miners of the New York–Pennsylvania League.
The Miners found his playing ability to be lacking and sent him to the Cincinnati Reds affiliate, the Nashville Volunteers, in a trade for Tiny Chaplin.
From Nashville, he was sent to the Durham Bulls, where the Bulls manager and catcher, Johnny Gooch, was credited with helping control the wildness of Vander Meer's pitching.
In 1936, he posted a record of 19 wins against six losses for Durham.

Vander Meer made his major league debut with the Cincinnati Reds on April 22, 1937 at the age of 22.
He went 3–4 before being sent back to the minor leagues with the Syracuse Chiefs for most of the season when the Reds recalled him in September.
The following year on June 11, 1938, Vander Meer pitched a no-hitter against the Boston Bees.
Four days later against the Brooklyn Dodgers in what was the first night game ever held at Ebbets Field, he threw another no-hitter, becoming the only player in major league history to throw two straight no-hitters, a historic record that has never been tied and almost certainly will never be beaten.

Vander Meer's performance earned him the role as the starting pitcher for the National League team in the 1938 All-Star game held at Cincinnati's Crosley Field.
The American League team – having won four of the previous five All-Star games – was favored to win the game, but Vander Meer pitched three scoreless innings and allowed only one hit, as the National League went on to win 4–1.
He ended the season with a 15–10 record and a 3.12 earned run average for the fourth place Reds.
He might have won more games, but spent nearly a month in the hospital being treated for boils late in the season.

After his impressive rookie season, Vander Meer had a disappointing 1939 season, when he fell ill during spring training, and then suffered an injury when he slipped on a wet pitching mound in Pittsburgh.
He posted a 5–9 record and an earned run average of 4.67.
Early in the 1940 season, he began to experience problems controlling the accuracy of his pitches.
In June, the Reds released him back to the minor leagues where he played for the Indianapolis Indians and went 6–4.
He returned to the major leagues in September and posted a 3–1 record, including a 12-inning victory against Philadelphia on September 18, that clinched the National League pennant for the Reds.
In the 13th inning, Vander Meer hit a double, advanced to third base on a sacrifice fly, then scored the winning run on a squeeze bunt.
In the 1940 World Series against the Detroit Tigers, Vander Meer made only one appearance when he entered Game 5 in the fifth inning with the Reds trailing 7–0.
He pitched three scoreless innings as the Reds lost 8–0.
The Reds went on to win the series in seven games.
It would be the only post-season appearance of Vander Meer's career.

In 1941, Vander Meer's performance improved somewhat with a 16–12 record and six shutouts while leading the league with 202 strikeouts.
On June 6, 1941 in a game against Philadelphia, he allowed only one hit.
Vander Meer later recalled that the only hit in the game could have been ruled an error, as shortstop Eddie Joost fielded the ground ball, then dropped it before throwing to first base.
He earned his third All-Star selection in the 1942 All-Star Game, and once again threw three scoreless innings in a 3–1 loss to the American League.
He finished the 1942 season with a career-high 18 wins against 12 losses and once again led the league in strikeouts.
He posted a 15–16 record in 1943 for the second place Reds and led the league in strikeouts for a third consecutive year.
On March 3, 1944, Vander Meer joined the United States Navy and was stationed at Sampson Naval Training Station in New York where
Born in Prospect Park, New Jersey, he moved with his family to Midland Park, New Jersey in 1918.  He had an inauspicious start to his professional baseball career. He was signed by the Brooklyn Dodgers as an amateur free agent in 1933 and assigned to the Dayton Ducks. Dayton then sold his contract to a Boston Bees minor league affiliate, the Scranton Miners of the New York–Pennsylvania League. The Miners found his playing ability to be lacking and sent him to the Cincinnati Reds affiliate, the Nashville Volunteers, in a trade for Tiny Chaplin. From Nashville, he was sent to the Durham Bulls, where the Bulls manager and catcher, Johnny Gooch, was credited with helping control the wildness of Vander Meer's pitching. In 1936, he posted a record of 19 wins against six losses for Durham.
Vander Meer made his major league debut with the Cincinnati Reds on April 22, 1937 at the age of 22. He went 3–4 before being sent back to the minor leagues with the Syracuse Chiefs for most of the season when the Reds recalled him in September. The following year on June 11, 1938, Vander Meer pitched a no-hitter against the Boston Bees. Four days later against the Brooklyn Dodgers in what was the first night game ever held at Ebbets Field, he threw another no-hitter, becoming the only player in major league history to throw two straight no-hitters, a historic record that has never been tied and almost certainly will never be beaten.
Vander Meer's performance earned him the role as the starting pitcher for the National League team in the 1938 All-Star game held at Cincinnati's Crosley Field. The American League team – having won four of the previous five All-Star games – was favored to win the game, but Vander Meer pitched three scoreless innings and allowed only one hit, as the National League went on to win 4–1. He ended the season with a 15–10 record and a 3.12 earned run average for the fourth place Reds. He might have won more games, but spent nearly a month in the hospital being treated for boils late in the season.
After his impressive rookie season, Vander Meer had a disappointing 1939 season, when he fell ill during spring training, and then suffered an injury when he slipped on a wet pitching mound in Pittsburgh. He posted a 5–9 record and an earned run average of 4.67. Early in the 1940 season, he began to experience problems controlling the accuracy of his pitches. In June, the Reds released him back to the minor leagues where he played for the Indianapolis Indians and went 6–4. He returned to the major leagues in September and posted a 3–1 record, including a 12-inning victory against Philadelphia on September 18, that clinched the National League pennant for the Reds. In the 13th inning, Vander Meer hit a double, advanced to third base on a sacrifice fly, then scored the winning run on a squeeze bunt. In the 1940 World Series against the Detroit Tigers, Vander Meer made only one appearance when he entered Game 5 in the fifth inning with the Reds trailing 7–0. He pitched three scoreless innings as the Reds lost 8–0. The Reds went on to win the series in seven games. It would be the only post-season appearance of Vander Meer's career.
In 1941, Vander Meer's performance improved somewhat with a 16–12 record and six shutouts while leading the league with 202 strikeouts. On June 6, 1941 in a game against Philadelphia, he allowed only one hit. Vander Meer later recalled that the only hit in the game could have been ruled an error, as shortstop Eddie Joost fielded the ground ball, then dropped it before throwing to first base. He earned his third All-Star selection in the 1942 All-Star Game, and once again threw three scoreless innings in a 3–1 loss to the American League. He finished the 1942 season with a career-high 18 wins against 12 losses and once again led the league in strikeouts. He posted a 15–16 record in 1943 for the second place Reds and led the league in strikeouts for a third consecutive year. On March 3, 1944, Vander Meer joined the United States Navy and was stationed at Sampson Naval Training Station in New York where
Johnny Vander Meer