Upon Burr's marriage, he became stepfather to the two teenage sons of his wife's first marriage.
Augustine James Frederick Prevost (called Frederick) and John Bartow Prevost had both joined their father in the Royal American Regiment in December 1780, at the ages of 16 and 14.
When they returned in 1783 to become citizens of the United States, Burr acted as a father to them: he assumed responsibility for their education, gave both of them clerkships in his law office, and frequently was accompanied by one of them as an assistant when he traveled on business.
John was later appointed by Thomas Jefferson to a post in the Territory of Orleans as the first judge of the Louisiana Supreme Court.

Burr served as a guardian to Nathalie de Lage de Volude (1782–1841) from 1794 to 1801, during Theodosia's childhood.
The young daughter of a French marquis, Nathalie had been taken to New York for safety during the French Revolution by her governess Caroline de Senat.
Burr opened his home to them, allowing Madame Senat to tutor private students there along with his daughter, and Nathalie became a companion and close friend to Theodosia.
While traveling to France for an extended visit in 1801, Nathalie met Thomas Sumter Jr., a diplomat and the son of General Thomas Sumter.
They married in Paris in March 1802, before returning to his home in South Carolina.
 From 1810 to 1821, they lived in Rio de Janeiro, where Sumter served as the American ambassador to Portugal during the transfer of the Portuguese Court to Brazil.
One of their children, Thomas De Lage Sumter, was a Congressman from South Carolina.

In the 1790s, Burr also took the painter John Vanderlyn into his home as a protégé, and provided him with financial support and patronage for 20 years.
He arranged Vanderlyn's training by Gilbert Stuart in Philadelphia and sent him in 1796 to the École des Beaux-Arts in Paris where he remained for six years.
Upon Burr's marriage, he became stepfather to the two teenage sons of his wife's first marriage. Augustine James Frederick Prevost (called Frederick) and John Bartow Prevost had both joined their father in the Royal American Regiment in December 1780, at the ages of 16 and 14. When they returned in 1783 to become citizens of the United States, Burr acted as a father to them: he assumed responsibility for their education, gave both of them clerkships in his law office, and frequently was accompanied by one of them as an assistant when he traveled on business. John was later appointed by Thomas Jefferson to a post in the Territory of Orleans as the first judge of the Louisiana Supreme Court.
Burr served as a guardian to Nathalie de Lage de Volude (1782–1841) from 1794 to 1801, during Theodosia's childhood. The young daughter of a French marquis, Nathalie had been taken to New York for safety during the French Revolution by her governess Caroline de Senat. Burr opened his home to them, allowing Madame Senat to tutor private students there along with his daughter, and Nathalie became a companion and close friend to Theodosia. While traveling to France for an extended visit in 1801, Nathalie met Thomas Sumter Jr., a diplomat and the son of General Thomas Sumter. They married in Paris in March 1802, before returning to his home in South Carolina.  From 1810 to 1821, they lived in Rio de Janeiro, where Sumter served as the American ambassador to Portugal during the transfer of the Portuguese Court to Brazil. One of their children, Thomas De Lage Sumter, was a Congressman from South Carolina.
In the 1790s, Burr also took the painter John Vanderlyn into his home as a protégé, and provided him with financial support and patronage for 20 years. He arranged Vanderlyn's training by Gilbert Stuart in Philadelphia and sent him in 1796 to the École des Beaux-Arts in Paris where he remained for six years.
Aaron Burr