Randolph's film career began in 1936 with Black Network.
She went on to do several Oscar Micheaux films, among them: Swing, Lying Lips and The Notorious Elinor Lee.
Broadway roles in The Male Animal and Harlem Cavalcade soon followed.
Around the same time, Randolph broke into radio, helped by people she met at The Clam House, who got her a CBS audition.
She began working on various radio shows: Young Dr. Malone, Romance of Helen Trent and  Big Sister.

She went on to become a regular cast member on Abie's Irish Rose, Kitty Foyle, and Miss Hattie with Ethel Barrymore, where she had the role of Venus.
Randolph also appeared on Rudy Vallée's radio show and on Grand Central Station.

She continued working in films until the 1960s, and was one of the first black women to become a comedy favorite on television.
Randolph was the first African-American performer to star in a regularly scheduled network television show, appearing in DuMont's The Laytons.
This short-lived program was on the air two months in 1948.

Although sometimes uncredited, Randolph was the voice of Petunia in the popular Paramount Famous Studios, Little Audrey.
The following is a list of cartoons in which Randolph voiced Petunia:
Butterscotch and Soda (1948)
The Lost Dream (1949)
Song of the Birds (1949)
Dot's Diary (Unknown)
During the 1948-1949 television season, Randolph starred for about a year in her own daytime musical TV program for DuMont, Amanda, which aired Mon-Fridays from 12noon to 12:15pm ET, making her the first African-American woman with her own show on daytime television.
Randolph did not settle in California until 1949, when she earned a role in Sidney Poitier's No Way Out.
Even though she was working in New York and her younger sister, Lillian, had been working in Hollywood for some time, newspapers often got the two sisters mixed up, doing a story on Amanda but with a photo of Lillian and vice versa.
She then became a regular on the early TV series, The Amos 'n' Andy Show, as Sapphire's mother, Ramona Smith, from 1951 to 1953; she also played the same role for the show's radio version from 1951 to 1954.

Randolph then began working with her sister, Lillian, who played Madame Queen on the radio and television shows.
She was the star and titular character in The Beulah Show from 1953 to 1954, assuming the role from Lillian.
Randolph also did some work for CBS Radio Workshop in 1956, playing the role of the folk heroine Annie Christmas in The Legend of Annie Christmas.

Randolph had a recurring role as Louise the Maid on CBS's The Danny Thomas Show and appeared in the show's 1967 reunion program, which aired shortly after her death.
She guest-starred on the NBC anthology series, The Barbara Stanwyck Show.
In 1955, Amanda opened a restaurant in Los Angeles called "Mama's Place", where she did the cooking.

Despite all her film and television work, Randolph found herself slightly short of the requirements for a much-needed Screen Actors Guild pension at the age of 70 (both sisters had struggled for roles in the late 1930s).
A role was written for her to gain eligibility.
Randolph's film career began in 1936 with Black Network. She went on to do several Oscar Micheaux films, among them: Swing, Lying Lips and The Notorious Elinor Lee. Broadway roles in The Male Animal and Harlem Cavalcade soon followed. Around the same time, Randolph broke into radio, helped by people she met at The Clam House, who got her a CBS audition. She began working on various radio shows: Young Dr. Malone, Romance of Helen Trent and  Big Sister.
She went on to become a regular cast member on Abie's Irish Rose, Kitty Foyle, and Miss Hattie with Ethel Barrymore, where she had the role of Venus. Randolph also appeared on Rudy Vallée's radio show and on Grand Central Station.
She continued working in films until the 1960s, and was one of the first black women to become a comedy favorite on television. Randolph was the first African-American performer to star in a regularly scheduled network television show, appearing in DuMont's The Laytons. This short-lived program was on the air two months in 1948.
Although sometimes uncredited, Randolph was the voice of Petunia in the popular Paramount Famous Studios, Little Audrey. The following is a list of cartoons in which Randolph voiced Petunia:
Butterscotch and Soda (1948)
The Lost Dream (1949)
Song of the Birds (1949)
Dot's Diary (Unknown)
During the 1948-1949 television season, Randolph starred for about a year in her own daytime musical TV program for DuMont, Amanda, which aired Mon-Fridays from 12noon to 12:15pm ET, making her the first African-American woman with her own show on daytime television. Randolph did not settle in California until 1949, when she earned a role in Sidney Poitier's No Way Out. Even though she was working in New York and her younger sister, Lillian, had been working in Hollywood for some time, newspapers often got the two sisters mixed up, doing a story on Amanda but with a photo of Lillian and vice versa. She then became a regular on the early TV series, The Amos 'n' Andy Show, as Sapphire's mother, Ramona Smith, from 1951 to 1953; she also played the same role for the show's radio version from 1951 to 1954.
Randolph then began working with her sister, Lillian, who played Madame Queen on the radio and television shows. She was the star and titular character in The Beulah Show from 1953 to 1954, assuming the role from Lillian. Randolph also did some work for CBS Radio Workshop in 1956, playing the role of the folk heroine Annie Christmas in The Legend of Annie Christmas.
Randolph had a recurring role as Louise the Maid on CBS's The Danny Thomas Show and appeared in the show's 1967 reunion program, which aired shortly after her death. She guest-starred on the NBC anthology series, The Barbara Stanwyck Show. In 1955, Amanda opened a restaurant in Los Angeles called "Mama's Place", where she did the cooking.
Despite all her film and television work, Randolph found herself slightly short of the requirements for a much-needed Screen Actors Guild pension at the age of 70 (both sisters had struggled for roles in the late 1930s). A role was written for her to gain eligibility.
Amanda Randolph