The wing was first activated at Tan Son Nhut Airport, South Vietnam in April 1966, as US Air Forces in Vietnam expanded during the Vietnam War.
 The 377th replaced the 6250th Combat Support Group, which had acted as host for Tan Son Nhut since the 33d Tactical Group was inactivated the previous year.
 It became responsible for operation and maintenance of USAF portion of Tan Son Nhut until it was inactivated in March 1973.

In Vietnam, the group's responsibilities included housing numerous tenant organizations including Seventh Air Force, base defense, and liaison with Republic of Vietnam Air Force.
 While serving in this capacity the 377th underwent numerous enemy attacks.
 It was also responsible for Binh Thuy Air Base, South Vietnam between 12 May and 1 July 1970.
 The group provided support for Seventh Air Force flying operations with from June to December 1966, and again after September 1971.
 From this date it also supported Lockheed C-130 Hercules aircraft deployed to the control of the 834th Air Division.

In January 1972, the 377th expanded to become the 377th Air Base Wing and for the first time gained combat units, when the 8th and 9th Special Operations Squadrons and the 310th Tactical Airlift Squadron were assigned or attached to it.
 These units had all been assigned to the 315th Tactical Airlift Wing, which was preparing for inactivation.
 The wing operated the Southeast Asia Central Instructor Pilots School, in which the 360th Tactical Electronic Warfare Squadron used C/EC-47s, from 15 February until about November 1972.
 The wing also operated a combat crew training school for de Havilland Canada C-7 Caribou at Phù Cát Air Base, South Vietnam, from the time the 315th Wing was inactivated on 15 March until October 1972.
 It resumed base flight operations at Tan Son Nhut in January 1972, operating and maintaining C-47, C-118, and T-39 aircraft.
 With the 8th Special Operations Squadron (A-37s), the 377th performed strike missions from January through October 1972; the 9th Special Operations Squadron (O-2s and C-47s) conducted psychological warfare operations, January until –February 1972; the 21st Tactical Air Support Squadron (Light) conducted air liaison and forward air control operations from March 1972 until 28 January 1973; the 310th Tactical Airlift Squadron (C/UC-123s, January–June 1972 and C-7s, March–October 1972) performed airlift and airdrop missions until October 1972; the 360th Tactical Electronic Warfare Squadron (C/EC-47s) conducted airborne radio-direction finding operations, February–November 1972, and psychological warfare operations, February–August 1972.
 The wing established an operating location of the wing headquarters at Bien Hoa Air Base, South Vietnam, on 14 April 1972 to provide turn-around service for McDonnell F-4 Phantom IIs of other organizations.
 It was replaced on 20 June 1972 by Detachment 1 of the wing headquarters, which continued the F-4 turn-around service and added LTV A-7 Corsair II turn-around service on 30 October 1972.
 The detachment continued operations through 11 February 1973.

As the wing phased down for inactivation from February 1973, it transferred many assets to Republic of Vietnam Air Force.
The wing was first activated at Tan Son Nhut Airport, South Vietnam in April 1966, as US Air Forces in Vietnam expanded during the Vietnam War.  The 377th replaced the 6250th Combat Support Group, which had acted as host for Tan Son Nhut since the 33d Tactical Group was inactivated the previous year.  It became responsible for operation and maintenance of USAF portion of Tan Son Nhut until it was inactivated in March 1973.
In Vietnam, the group's responsibilities included housing numerous tenant organizations including Seventh Air Force, base defense, and liaison with Republic of Vietnam Air Force.  While serving in this capacity the 377th underwent numerous enemy attacks.  It was also responsible for Binh Thuy Air Base, South Vietnam between 12 May and 1 July 1970.  The group provided support for Seventh Air Force flying operations with from June to December 1966, and again after September 1971.  From this date it also supported Lockheed C-130 Hercules aircraft deployed to the control of the 834th Air Division.
In January 1972, the 377th expanded to become the 377th Air Base Wing and for the first time gained combat units, when the 8th and 9th Special Operations Squadrons and the 310th Tactical Airlift Squadron were assigned or attached to it.  These units had all been assigned to the 315th Tactical Airlift Wing, which was preparing for inactivation.  The wing operated the Southeast Asia Central Instructor Pilots School, in which the 360th Tactical Electronic Warfare Squadron used C/EC-47s, from 15 February until about November 1972.  The wing also operated a combat crew training school for de Havilland Canada C-7 Caribou at Phù Cát Air Base, South Vietnam, from the time the 315th Wing was inactivated on 15 March until October 1972.  It resumed base flight operations at Tan Son Nhut in January 1972, operating and maintaining C-47, C-118, and T-39 aircraft.  With the 8th Special Operations Squadron (A-37s), the 377th performed strike missions from January through October 1972; the 9th Special Operations Squadron (O-2s and C-47s) conducted psychological warfare operations, January until –February 1972; the 21st Tactical Air Support Squadron (Light) conducted air liaison and forward air control operations from March 1972 until 28 January 1973; the 310th Tactical Airlift Squadron (C/UC-123s, January–June 1972 and C-7s, March–October 1972) performed airlift and airdrop missions until October 1972; the 360th Tactical Electronic Warfare Squadron (C/EC-47s) conducted airborne radio-direction finding operations, February–November 1972, and psychological warfare operations, February–August 1972.  The wing established an operating location of the wing headquarters at Bien Hoa Air Base, South Vietnam, on 14 April 1972 to provide turn-around service for McDonnell F-4 Phantom IIs of other organizations.  It was replaced on 20 June 1972 by Detachment 1 of the wing headquarters, which continued the F-4 turn-around service and added LTV A-7 Corsair II turn-around service on 30 October 1972.  The detachment continued operations through 11 February 1973.
As the wing phased down for inactivation from February 1973, it transferred many assets to Republic of Vietnam Air Force.
377th Air Base Wing