After the Fall of Constantinople, according to the Capitulations of the Ottoman Empire with the Republic of Genoa, the church, which by that time was known by the Turks under the name of Mesa Domenico, remained in Genoese hands, but between 1475 and 1478 it was transformed, with minor modifications, into a mosque by the Ottoman Sultan Mehmed II and became known as Galata Camii ("Galata Mosque") or Cami-i Kebir ("Great Mosque").
The friars were transferred in the friary of San Pietro in Galata in 1476, while all the altar clothes had already been brought to Genoa, and the archives to Caffa.

Towards the end of the century Sultan Bayezid II assigned the building to those Muslims of Spain (Moriscos) who had fled the Spanish Inquisition and migrated to Istanbul; hence the present name Arap Camii (Arab Mosque).
Sultan Mehmet III repaired the building, and towards the end of seventeenth century the houses which encroached upon the mosque were pulled down in order to avoid noise.

After the 1731 Great Fire of Galata, in 1734/35 the mother of Mahmut I, Saliha Sultan renovated the building, changing the windows and the portal from the Gothic to the Ottoman style.
After another fire in 1808, in the mid-nineteenth century, the daughter of Mahmud II, Adile Sultan, repaired the mosque again and in 1868 built a şadirvan (fountain for ritual ablutions before praying) in the courtyard.

Between 1913 and 1919, Giridli Hasan Bey extensively restored the edifice again.
During the replacement of the wooden floor, several Genoese tombstones dating back to between the first half of fourteenth and up to the middle of the fifteenth centuries were discovered.
They were brought to the Istanbul Archaeology Museum.

At the beginning of the 2010s, the mosque underwent an extensive restoration, which was finished in 2013.
An inaccurate inscription that the mosque was founded in 715 AD was also installed in front of the mosque as part of the restoration.
After the Fall of Constantinople, according to the Capitulations of the Ottoman Empire with the Republic of Genoa, the church, which by that time was known by the Turks under the name of Mesa Domenico, remained in Genoese hands, but between 1475 and 1478 it was transformed, with minor modifications, into a mosque by the Ottoman Sultan Mehmed II and became known as Galata Camii ("Galata Mosque") or Cami-i Kebir ("Great Mosque"). The friars were transferred in the friary of San Pietro in Galata in 1476, while all the altar clothes had already been brought to Genoa, and the archives to Caffa.
Towards the end of the century Sultan Bayezid II assigned the building to those Muslims of Spain (Moriscos) who had fled the Spanish Inquisition and migrated to Istanbul; hence the present name Arap Camii (Arab Mosque). Sultan Mehmet III repaired the building, and towards the end of seventeenth century the houses which encroached upon the mosque were pulled down in order to avoid noise.
After the 1731 Great Fire of Galata, in 1734/35 the mother of Mahmut I, Saliha Sultan renovated the building, changing the windows and the portal from the Gothic to the Ottoman style. After another fire in 1808, in the mid-nineteenth century, the daughter of Mahmud II, Adile Sultan, repaired the mosque again and in 1868 built a şadirvan (fountain for ritual ablutions before praying) in the courtyard.
Between 1913 and 1919, Giridli Hasan Bey extensively restored the edifice again. During the replacement of the wooden floor, several Genoese tombstones dating back to between the first half of fourteenth and up to the middle of the fifteenth centuries were discovered. They were brought to the Istanbul Archaeology Museum.
At the beginning of the 2010s, the mosque underwent an extensive restoration, which was finished in 2013. An inaccurate inscription that the mosque was founded in 715 AD was also installed in front of the mosque as part of the restoration.
Arap Mosque