From 1905 to 1910, Ransom was an assistant professor of Archaeology and Art at Bryn Mawr College in Pennsylvania, eventually becoming chair of her department.
She also served on the managing committee of the American School of Classical Studies at Athens.
In 1909, Ransom became the first female (corresponding) member of the Deutsches Archäologisches Institut (German Archaeological Institute), founded in 1898.

She also participated in the Deutsche Orient-Gesellschaft (DOG, German  Oriental  Society).
Such affiliations connected Ransom to an international  community  of current scholars and reinforced her position as an active member of the academic world.

In 1909-1910 she was a vice-president of the Pennsylvania chapter of the Archaeological Institute of America.

In 1910 she became assistant curator in the recently established Department of Egyptian Art of the Metropolitan Museum of Art (MMA) in New York under the direction of First Curator Albert M. Lythgoe.
 From 1910 to 1916, she worked with the artifacts in the collections, co-authoring the Handbook of the Egyptian Collection of the Museum (1911).
In 1912, Ransom received an honorary doctorate (Litt.
D.) from Mount Holyoke College on its 75th anniversary.

Between 1913 and 1916, the Tomb of Perneb was moved from Egypt and reconstructed at the Metropolitan Museum.
While Lythgoe and others were in the field during the winter, Ransom supervised the American side of the work.
This included administration and planning for the reception and installation of the pieces of the tomb, and for the exhibit's opening.
Reconstructing the tomb took three years.
It opened to the public in 1916.
The opening was accompanied by the publication of an 80-page booklet, The Tomb of Perneb, co-written by Lythgoe and Ransom.

In 1916 Ransom married Grant Williams, a real estate developer in Toledo, Ohio, and returned there to live.
Although they did not have children, family obligations to her husband and aging mother limited Ransom's ability to take on major professional commitments.
She continued to work with the  Metropolitan Museum of Art  and the New York Historical Society (NYHS) by commuting from Toledo, Ohio, to New York several times a year.

In the winter of 1916/17 she cataloged the Egyptian collections of the Cleveland Museum of Art and the Minneapolis Institute of Arts.
In 1918, she catalogued the Egyptian holdings of the Detroit Museum of Art and the Toledo Museum of Art.

From 1917 to 1924, she was a curator of the Egyptian holdings of the New York Historical Society, cataloguing the Abbott Collection of Egyptian Antiquities.

She repeatedly refused offers that would have required relocating to Chicago, New York, or Egypt.
In a number of cases, most notably that of the Edwin Smith Medical Papyrus, she directed potentially prestigious work to others.

The papyrus is probably the most valuable one owned by the Society and I am ready to waive my interest in it, in the hope that it may be published sooner and better than I could do it.

— Ransom Williams to Breasted, Letter, November 22, 1920
During the 1926/27 season, Caroline  Ransom  Williams took part in the Epigraphic Survey of the inscriptions at Luxor, at the invitation of Breasted of the University of Chicago.
She was one of four epigraphers on staff, the others being  William  F. Edgerton, John A. Wilson and the director of the site, Harold H. Nelson.
In the Oriental Institute's report, Breasted expressed his "profound appreciation that Dr. Williams worked an entire season at Medinet Habu out of pure interest in the project and with almost no remuneration."
Ransom Williams worked on the Mortuary Temple of Ramesses III at Medinet Habu.
She is credited with largely establishing the epigraphic standards for the group's work, with the assistance of Edgerton and Wilson.

In 1927/28 she was the first lecturer in Egyptian Art and Archeology at the University of Michigan.

In 1929, Ransom Williams became president of the Mid-West Branch of the American Oriental Society.
 She was the first woman officer of the AOS.

In 1932, she published The
From 1905 to 1910, Ransom was an assistant professor of Archaeology and Art at Bryn Mawr College in Pennsylvania, eventually becoming chair of her department. She also served on the managing committee of the American School of Classical Studies at Athens. In 1909, Ransom became the first female (corresponding) member of the Deutsches Archäologisches Institut (German Archaeological Institute), founded in 1898.
She also participated in the Deutsche Orient-Gesellschaft (DOG, German  Oriental  Society). Such affiliations connected Ransom to an international  community  of current scholars and reinforced her position as an active member of the academic world.
In 1909-1910 she was a vice-president of the Pennsylvania chapter of the Archaeological Institute of America.
In 1910 she became assistant curator in the recently established Department of Egyptian Art of the Metropolitan Museum of Art (MMA) in New York under the direction of First Curator Albert M. Lythgoe.  From 1910 to 1916, she worked with the artifacts in the collections, co-authoring the Handbook of the Egyptian Collection of the Museum (1911). In 1912, Ransom received an honorary doctorate (Litt. D.) from Mount Holyoke College on its 75th anniversary.
Between 1913 and 1916, the Tomb of Perneb was moved from Egypt and reconstructed at the Metropolitan Museum. While Lythgoe and others were in the field during the winter, Ransom supervised the American side of the work. This included administration and planning for the reception and installation of the pieces of the tomb, and for the exhibit's opening. Reconstructing the tomb took three years. It opened to the public in 1916. The opening was accompanied by the publication of an 80-page booklet, The Tomb of Perneb, co-written by Lythgoe and Ransom.
In 1916 Ransom married Grant Williams, a real estate developer in Toledo, Ohio, and returned there to live. Although they did not have children, family obligations to her husband and aging mother limited Ransom's ability to take on major professional commitments. She continued to work with the  Metropolitan Museum of Art  and the New York Historical Society (NYHS) by commuting from Toledo, Ohio, to New York several times a year.
In the winter of 1916/17 she cataloged the Egyptian collections of the Cleveland Museum of Art and the Minneapolis Institute of Arts. In 1918, she catalogued the Egyptian holdings of the Detroit Museum of Art and the Toledo Museum of Art.
From 1917 to 1924, she was a curator of the Egyptian holdings of the New York Historical Society, cataloguing the Abbott Collection of Egyptian Antiquities.
She repeatedly refused offers that would have required relocating to Chicago, New York, or Egypt. In a number of cases, most notably that of the Edwin Smith Medical Papyrus, she directed potentially prestigious work to others.
The papyrus is probably the most valuable one owned by the Society and I am ready to waive my interest in it, in the hope that it may be published sooner and better than I could do it.
— Ransom Williams to Breasted, Letter, November 22, 1920
During the 1926/27 season, Caroline  Ransom  Williams took part in the Epigraphic Survey of the inscriptions at Luxor, at the invitation of Breasted of the University of Chicago. She was one of four epigraphers on staff, the others being  William  F. Edgerton, John A. Wilson and the director of the site, Harold H. Nelson. In the Oriental Institute's report, Breasted expressed his "profound appreciation that Dr. Williams worked an entire season at Medinet Habu out of pure interest in the project and with almost no remuneration." Ransom Williams worked on the Mortuary Temple of Ramesses III at Medinet Habu. She is credited with largely establishing the epigraphic standards for the group's work, with the assistance of Edgerton and Wilson.
In 1927/28 she was the first lecturer in Egyptian Art and Archeology at the University of Michigan.
In 1929, Ransom Williams became president of the Mid-West Branch of the American Oriental Society.  She was the first woman officer of the AOS.
In 1932, she published The
Caroline Ransom Williams