The town of Lohr am Main was settled no later than the 8th century, and by the time of its first documentary mention in 1295 it was already the main centre of the County of Rieneck.

In 1333 Lohr was granted town rights, which can be explained by the disagreement about the inheritance of the Counts of Rieneck-Rothenfels, which had died out.
Indeed, Lohr had been a "town" for quite some time already.
The town lords were the Counts of Rieneck, who had been enfeoffed by the Archbishop of Mainz (evidence of this is only available beginning in 1366).

In 1559, after the last Count of Rieneck, Philipp III’s death, the fief passed to the Archbishopric of Mainz.
From 1603 to 1618, during the "Recatholization" many townsfolk fell victim to persecution as witches.
The former Oberamt of the Prince-Bishopric of Würzburg was secularized in favour of Prince Primate von Dalberg's Principality of Aschaffenburg and passed along with this state in 1814 (by this time it had become a part of the Grand Duchy of Frankfurt) to the Kingdom of Bavaria.
In the course of administrative reform in Bavaria, the current town-level municipality came into being with the Gemeindeedikt ("Municipal Edict") of 1818.

In 1875, the Alte Mainbrücke (old Main bridge) was built.
In 1936 came the new Lindig neighbourhood.
In 1939, Sendelbach was amalgamated with the town.

Between 1940 and 1945, under Nazi rule more than 600 children, women and men were deported to Sonnenstein and Grafeneck, as well as to the Auschwitz and Mauthausen concentration camps from what was then the Health and Care Institute (now the Regional Hospital for Psychiatry) as part of the Euthanasia programme, "Action T4".
Since 1993, a bronze relief in the street by artist Rainer Stoltz serves as a memorial to these victims of the Nazi régime.

On 2 April 1945, Lohr citizen Karl Brand was murdered, because he wanted to surrender the town to American troops without a fight.
Since 1979, a memorial stone has recalled this.

From 1972 to 1978, the surrounding communities of Halsbach, Rodenbach, Ruppertshütten, Sackenbach, Steinbach, Wombach and Pflochsbach were amalgamated with the town.
On 1 July 1972, the greater part of the District of Lohr (Landkreis Lohr) became part of the new District of Mittelmain (Landkreis Mittelmain), which in 1973 was given its current name, Main-Spessart.
At first, Lohr am Main was chosen as the district seat (Kreisstadt), but in October 1972 it was decided that Karlstadt would be the new district seat, and the Landratsamt (district office) was moved from Lohr to Karlstadt.
The town of Lohr am Main was settled no later than the 8th century, and by the time of its first documentary mention in 1295 it was already the main centre of the County of Rieneck. 
In 1333 Lohr was granted town rights, which can be explained by the disagreement about the inheritance of the Counts of Rieneck-Rothenfels, which had died out. Indeed, Lohr had been a "town" for quite some time already. The town lords were the Counts of Rieneck, who had been enfeoffed by the Archbishop of Mainz (evidence of this is only available beginning in 1366). 
In 1559, after the last Count of Rieneck, Philipp III’s death, the fief passed to the Archbishopric of Mainz. From 1603 to 1618, during the "Recatholization" many townsfolk fell victim to persecution as witches. The former Oberamt of the Prince-Bishopric of Würzburg was secularized in favour of Prince Primate von Dalberg's Principality of Aschaffenburg and passed along with this state in 1814 (by this time it had become a part of the Grand Duchy of Frankfurt) to the Kingdom of Bavaria. In the course of administrative reform in Bavaria, the current town-level municipality came into being with the Gemeindeedikt ("Municipal Edict") of 1818. 
In 1875, the Alte Mainbrücke (old Main bridge) was built. In 1936 came the new Lindig neighbourhood. In 1939, Sendelbach was amalgamated with the town.
Between 1940 and 1945, under Nazi rule more than 600 children, women and men were deported to Sonnenstein and Grafeneck, as well as to the Auschwitz and Mauthausen concentration camps from what was then the Health and Care Institute (now the Regional Hospital for Psychiatry) as part of the Euthanasia programme, "Action T4". Since 1993, a bronze relief in the street by artist Rainer Stoltz serves as a memorial to these victims of the Nazi régime.
On 2 April 1945, Lohr citizen Karl Brand was murdered, because he wanted to surrender the town to American troops without a fight. Since 1979, a memorial stone has recalled this.
From 1972 to 1978, the surrounding communities of Halsbach, Rodenbach, Ruppertshütten, Sackenbach, Steinbach, Wombach and Pflochsbach were amalgamated with the town. On 1 July 1972, the greater part of the District of Lohr (Landkreis Lohr) became part of the new District of Mittelmain (Landkreis Mittelmain), which in 1973 was given its current name, Main-Spessart. At first, Lohr am Main was chosen as the district seat (Kreisstadt), but in October 1972 it was decided that Karlstadt would be the new district seat, and the Landratsamt (district office) was moved from Lohr to Karlstadt.
Lohr am Main