Renée was not only in correspondence with a very large number of Protestants abroad, with intellectual sympathizers like Vergerio, Camillo Renato, Giulio di Milano, and Francis Dryander, but also that on two or three occasions, about 1550 or later, she partook of the Eucharist in the Protestant manner together with her daughters and fellow believers.
Meanwhile, notwithstanding its external splendor, her life had grown sad.
The last of her French guests, the daughter and son-in-law of Madame de Soubise of Pons, had been obliged, in 1543, by the constraint imposed by the duke, to leave the court.
The Counter-Reformation, which had been operative in Rome since 1542, led to the introduction of a special court of the Inquisition at Ferrara, in 1545, through which, in 1550 and 1551, death sentences were decreed against Protestant sympathizers (Fannio of Faenza and Giorgio of Sicily), and executed by the secular arm.

Finally Duke Ercole lodged accusation against Renée before her nephew King Henry II of France, and through the Inquisitor Oriz, whom the king charged with this errand, Renée was arrested as a heretic, and declared forfeit of all possessions unless she recanted.
She resisted steadfastly for some time, until her two daughters were taken away from her, supposedly forever.
So, as a condition for being reunited with her children she had to recant and abjure her Protestant faith.
She then yielded, made confession on 23 September 1554, although subsequently she refused to attend Catholic worship, and especially the mass, which for her was a form of blasphemy. "
How seldom is there an example of steadfastness among aristocrats," wrote Calvin to Farel under date of 2 February 1555.
Renée was not only in correspondence with a very large number of Protestants abroad, with intellectual sympathizers like Vergerio, Camillo Renato, Giulio di Milano, and Francis Dryander, but also that on two or three occasions, about 1550 or later, she partook of the Eucharist in the Protestant manner together with her daughters and fellow believers. Meanwhile, notwithstanding its external splendor, her life had grown sad. The last of her French guests, the daughter and son-in-law of Madame de Soubise of Pons, had been obliged, in 1543, by the constraint imposed by the duke, to leave the court. The Counter-Reformation, which had been operative in Rome since 1542, led to the introduction of a special court of the Inquisition at Ferrara, in 1545, through which, in 1550 and 1551, death sentences were decreed against Protestant sympathizers (Fannio of Faenza and Giorgio of Sicily), and executed by the secular arm.
Finally Duke Ercole lodged accusation against Renée before her nephew King Henry II of France, and through the Inquisitor Oriz, whom the king charged with this errand, Renée was arrested as a heretic, and declared forfeit of all possessions unless she recanted. She resisted steadfastly for some time, until her two daughters were taken away from her, supposedly forever. So, as a condition for being reunited with her children she had to recant and abjure her Protestant faith. She then yielded, made confession on 23 September 1554, although subsequently she refused to attend Catholic worship, and especially the mass, which for her was a form of blasphemy. "How seldom is there an example of steadfastness among aristocrats," wrote Calvin to Farel under date of 2 February 1555.
Renée of France