Using the working titles of Return of the Creature and Return of the Creature from the Black Lagoon, filming took place at Marineland of Florida which played the part of the film's Ocean Harbor Oceanarium.
The St. Johns River stood in for the Amazon in the film.

The Lobster House restaurant where the Creature kidnaps Lori Nelson was located in Jacksonville, Florida.
It was destroyed by fire in 1962.
The Diamondhead Restaurant (now the River City Brewing Co.) was built adjacent to the site where the old Lobster House once stood.
Friendship Park was built on the vacant land near where the Lobster House stood.

Revenge of the Creature marks the screen debut of Clint Eastwood, who appears uncredited as a lab technician named Jennings early in the story.
He is shown having a discussion with Professor Ferguson, accusing a test subject cat of eating a lab rat, only to find the rat in his lab coat pocket.
Using the working titles of Return of the Creature and Return of the Creature from the Black Lagoon, filming took place at Marineland of Florida which played the part of the film's Ocean Harbor Oceanarium. The St. Johns River stood in for the Amazon in the film.
The Lobster House restaurant where the Creature kidnaps Lori Nelson was located in Jacksonville, Florida. It was destroyed by fire in 1962. The Diamondhead Restaurant (now the River City Brewing Co.) was built adjacent to the site where the old Lobster House once stood. Friendship Park was built on the vacant land near where the Lobster House stood.
Revenge of the Creature marks the screen debut of Clint Eastwood, who appears uncredited as a lab technician named Jennings early in the story. He is shown having a discussion with Professor Ferguson, accusing a test subject cat of eating a lab rat, only to find the rat in his lab coat pocket.
Revenge of the Creature