Route 112 ran from West Preston south on Gilbert Road, turning east at Miller Street and south onto St Georges Road.
It then traversed the suburbs of Thornbury, Northcote and Fitzroy North.
At Edinburgh Gardens it turned into Brunswick Street and continued south into Fitzroy.
It turn west into Victoria Parade, passing through St Vincent's Plaza, East Melbourne, St Vincent's Hospital, the Eye & Ear Hospital and then turned south onto Gisborne Street.
It then continue south west along MacArthur Street and turned west into Collins Street, entering the CBD, passing Melbourne Town Hall and City Square.

It turned south from Collins Street into Spencer Street, passing Southern Cross station.
It then crossed the Yarra River and entered Southbank on Clarendon Street where it traversed through South Melbourne.
It turned south west at Albert Road, passing the Melbourne Sports & Aquatic Centre, it turned south-east briefly onto Canterbury Road, Albert Park and turned south-west into Mills Street, and finally south-east into Danks Street, Middle Park, Patterson Street and Park Street, where it continued and arrives at its terminus at Fitzroy Street, St Kilda.
Route 112 ran from West Preston south on Gilbert Road, turning east at Miller Street and south onto St Georges Road. It then traversed the suburbs of Thornbury, Northcote and Fitzroy North. At Edinburgh Gardens it turned into Brunswick Street and continued south into Fitzroy. It turn west into Victoria Parade, passing through St Vincent's Plaza, East Melbourne, St Vincent's Hospital, the Eye & Ear Hospital and then turned south onto Gisborne Street. It then continue south west along MacArthur Street and turned west into Collins Street, entering the CBD, passing Melbourne Town Hall and City Square.
It turned south from Collins Street into Spencer Street, passing Southern Cross station. It then crossed the Yarra River and entered Southbank on Clarendon Street where it traversed through South Melbourne. It turned south west at Albert Road, passing the Melbourne Sports & Aquatic Centre, it turned south-east briefly onto Canterbury Road, Albert Park and turned south-west into Mills Street, and finally south-east into Danks Street, Middle Park, Patterson Street and Park Street, where it continued and arrives at its terminus at Fitzroy Street, St Kilda.
Melbourne tram route 112