Medlen played his first professional baseball game on June 22, 2006, for the Danville Braves of the Appalachian League.
 He appeared in 20 games for Danville, and pitched a total of 22 innings, being credited with 1 win, no losses, and 10 saves.
In those 22 innings, Medlen allowed 14 hits and only 1 earned run.
He struck out 36 batters, and allowed only 2 walks.
 His ERA was 0.41 and his WHIP was 0.727.

Medlen played for three of the Braves minor league teams during 2007, progressing from the Rome Braves (single A, South Atlantic League), to the Myrtle Beach Pelicans (high A, Carolina League) and ending the season with the Mississippi Braves (AA, Southern League).
 
His statistics for these three teams were as follows:  For the Rome Braves, Medlen appeared in 17 games, logging 20.2 innings, with 33 strike-outs and 3 walks; he had an ERA of 0.87 and a WHIP of 0.774.
 For the Myrtle Beach Braves, Medlen appeared in 18 games, pitching 24 innings, with 28 strike-outs and 9 walks (2 of them intentional); he had an ERA of 1.12 and a WHIP of 1.230.
 For the Mississippi Braves, Medlen appeared in only 3 games, for a total of 2.1 innings.
 He had 2 strike-outs and 2 walks, allowing 4 hits and 3 earned runs (for an ERA of 11.57 and a WHIP of 2.571).

Medlen spent the entire 2008 season with the Mississippi Braves of the Southern League.
 He made 19 relief appearances from April 5 to June 1, and got his first start on June 5, 2012, against the Mobile BayBears (an Arizona Diamondbacks affiliate).
  He recorded 10 strike-outs in two of his starts, in a 7.0 inning start against the Pensacola Blue Wahoos (on July 7, 2008), a game in which he allowed 4 hits and 1 walk, but also allowed 3 runs, and in a 6.0 inning start against the Carolina Mudcats (on August 22, 2008), a game in which he allowed 3 hits and 1 walk, but no runs.
 For the season, Medlen started 17 games, with 6 wins and 5 losses.

Medlen was named Southern League pitcher of the week on July 14, 2008, after the week in which he had 10 strike-outs against the Blue Wahoos and a win against the Chattanooga Lookouts, in which he allowed 5 hits, 1 walk and 1 run over 6 innings, while striking out 6 batters.
Medlen played his first professional baseball game on June 22, 2006, for the Danville Braves of the Appalachian League.  He appeared in 20 games for Danville, and pitched a total of 22 innings, being credited with 1 win, no losses, and 10 saves. In those 22 innings, Medlen allowed 14 hits and only 1 earned run. He struck out 36 batters, and allowed only 2 walks.  His ERA was 0.41 and his WHIP was 0.727.
Medlen played for three of the Braves minor league teams during 2007, progressing from the Rome Braves (single A, South Atlantic League), to the Myrtle Beach Pelicans (high A, Carolina League) and ending the season with the Mississippi Braves (AA, Southern League).  
His statistics for these three teams were as follows:  For the Rome Braves, Medlen appeared in 17 games, logging 20.2 innings, with 33 strike-outs and 3 walks; he had an ERA of 0.87 and a WHIP of 0.774.  For the Myrtle Beach Braves, Medlen appeared in 18 games, pitching 24 innings, with 28 strike-outs and 9 walks (2 of them intentional); he had an ERA of 1.12 and a WHIP of 1.230.  For the Mississippi Braves, Medlen appeared in only 3 games, for a total of 2.1 innings.  He had 2 strike-outs and 2 walks, allowing 4 hits and 3 earned runs (for an ERA of 11.57 and a WHIP of 2.571).
Medlen spent the entire 2008 season with the Mississippi Braves of the Southern League.  He made 19 relief appearances from April 5 to June 1, and got his first start on June 5, 2012, against the Mobile BayBears (an Arizona Diamondbacks affiliate).   He recorded 10 strike-outs in two of his starts, in a 7.0 inning start against the Pensacola Blue Wahoos (on July 7, 2008), a game in which he allowed 4 hits and 1 walk, but also allowed 3 runs, and in a 6.0 inning start against the Carolina Mudcats (on August 22, 2008), a game in which he allowed 3 hits and 1 walk, but no runs.  For the season, Medlen started 17 games, with 6 wins and 5 losses.
Medlen was named Southern League pitcher of the week on July 14, 2008, after the week in which he had 10 strike-outs against the Blue Wahoos and a win against the Chattanooga Lookouts, in which he allowed 5 hits, 1 walk and 1 run over 6 innings, while striking out 6 batters.
Kris Medlen