The previous church has a four-manual pipe organ of 1840 by Samuel Renn.
In the present church there was also a four-manual organ, this was by Willis, and was followed in 1923 with an organ by Willis and Lewis, again with four manuals.
Due to the poor condition of the Willis Pipe Organ, the console was refitted in 1982 by Makin and speakers installed in the organ loft, much of the original Willis pipework was removed to make way for the speakers.
 In 2010 the Makin organ was superseded by another four-manual electronic organ by Makin with a new console.
 There is also a smaller two-manual Makin organ in the church.
A new Makin Westmorland Custom 4–74 organ was installed in October 2010.
It was dedicated by the Bishop of Warrington Rt.
Rev. Richard Blackburn on Sunday 7 November.
The main choir consists of boys and men, and there is also a chapel choir of women who sometimes join with the male choir.
 The choir sings at Sunday services, and also at a choral evensong on Wednesdays.
 Apart from the two cathedrals, it is the only choir in the diocese to regularly sing a full midweek choral evensong.
In addition to its liturgical duties, the choir also performs in concerts, including in the Trinity Arts Festival.
 From 2008 to 2017, the director of music was Ian Wells, the former assistant organist at Liverpool Cathedral.
The previous church has a four-manual pipe organ of 1840 by Samuel Renn. In the present church there was also a four-manual organ, this was by Willis, and was followed in 1923 with an organ by Willis and Lewis, again with four manuals. Due to the poor condition of the Willis Pipe Organ, the console was refitted in 1982 by Makin and speakers installed in the organ loft, much of the original Willis pipework was removed to make way for the speakers.  In 2010 the Makin organ was superseded by another four-manual electronic organ by Makin with a new console.  There is also a smaller two-manual Makin organ in the church. A new Makin Westmorland Custom 4–74 organ was installed in October 2010. It was dedicated by the Bishop of Warrington Rt. Rev. Richard Blackburn on Sunday 7 November. The main choir consists of boys and men, and there is also a chapel choir of women who sometimes join with the male choir.  The choir sings at Sunday services, and also at a choral evensong on Wednesdays.  Apart from the two cathedrals, it is the only choir in the diocese to regularly sing a full midweek choral evensong. In addition to its liturgical duties, the choir also performs in concerts, including in the Trinity Arts Festival.  From 2008 to 2017, the director of music was Ian Wells, the former assistant organist at Liverpool Cathedral.
Holy Trinity Church, Southport