Antoni Radziwiłł was born on 13 June 1775 in Vilnius to Michał Hieronim Radziwiłł and Helena née Przeździecka.
From 1792 he attended Göttingen University and was invited to the court of King Frederick William II of Prussia.
In 1796 he married Princess Louise of Prussia, the second daughter of Prince Augustus Ferdinand of Prussia and hence a niece of the late Prussian king Frederick the Great.
His new family convinced him that he should be a mediator between the Poles living under the Third Partition after the failed Kościuszko Uprising and the Prussian authorities in Berlin.
Fluctuating between Berlin, Warsaw and Saint Petersburg, Radziwiłł developed the idea of making the province of South Prussia the nucleus of a renewed Polish kingdom, ruled by the Prussian king in personal union.

During Napoleon's 1806 campaign in Poland during the War of the Fourth Coalition he tried to incite a Polish uprising against the French army and to convince Prince Józef Poniatowski to abandon his French allies and join the cause of the Russian Empire and Prussia.
He failed on both occasions, when Prussia suffered a crushing defeat at the Battle of Jena-Auerstedt.
Instead Napoleon's expedition sparked the Greater Poland Uprising, which led to the establishment of the Duchy of Warsaw under the rule of King Frederick Augustus I of Saxony with Prince Poniatowski as war minister.
In the following years Radziwiłł retired to his city palace in Berlin and concentrated on regaining his family's vast estates in the Russian partition from the hands of Emperor Alexander I of Russia.
Antoni Radziwiłł was born on 13 June 1775 in Vilnius to Michał Hieronim Radziwiłł and Helena née Przeździecka. From 1792 he attended Göttingen University and was invited to the court of King Frederick William II of Prussia. In 1796 he married Princess Louise of Prussia, the second daughter of Prince Augustus Ferdinand of Prussia and hence a niece of the late Prussian king Frederick the Great. His new family convinced him that he should be a mediator between the Poles living under the Third Partition after the failed Kościuszko Uprising and the Prussian authorities in Berlin. Fluctuating between Berlin, Warsaw and Saint Petersburg, Radziwiłł developed the idea of making the province of South Prussia the nucleus of a renewed Polish kingdom, ruled by the Prussian king in personal union.
During Napoleon's 1806 campaign in Poland during the War of the Fourth Coalition he tried to incite a Polish uprising against the French army and to convince Prince Józef Poniatowski to abandon his French allies and join the cause of the Russian Empire and Prussia. He failed on both occasions, when Prussia suffered a crushing defeat at the Battle of Jena-Auerstedt. Instead Napoleon's expedition sparked the Greater Poland Uprising, which led to the establishment of the Duchy of Warsaw under the rule of King Frederick Augustus I of Saxony with Prince Poniatowski as war minister. In the following years Radziwiłł retired to his city palace in Berlin and concentrated on regaining his family's vast estates in the Russian partition from the hands of Emperor Alexander I of Russia.
Antoni Radziwiłł