Douglas disregarded advice from party officials to wait until 1952 to run for the Senate, when Republican Senator Knowland would be up for reelection.
Fundraising for the campaign was a concern from the beginning; Douglas friend and aide Ed Lybeck wrote her that she would probably need to raise $150,000 ($1.8 million today), which Douglas considered a massive sum.
Lybeck wrote,
Now, you can win.
You will not be a favorite; you'll be rather a long shot.
But given luck and money and a hell of a lot of work, you can win ... but for Christ's sake don't commit suicide with no dough ... Maybe you can't crucify mankind on a cross of gold, but you can sure as hell crucify a statewide candidate upon a cross of no-gold.

On October 5, 1949, Douglas made a radio appearance announcing her candidacy.
She attacked Downey almost continuously throughout the remainder of the year, accusing him of being a do-nothing, a tool of big business, and an agent of oil interests.
She hired Harold Tipton, a newcomer to California who had managed a successful congressional campaign in the Seattle area, as her campaign manager.
Douglas realized that Nixon would most likely be the Republican nominee, and felt that were she to win the primary, the wide gap between Nixon's positions and hers would cause voters to rally to her.
Downey, who suffered from a severe ulcer, was initially undecided about running, but announced his candidacy in early December in a speech that included an attack on Douglas.
Earl Desmond, a member of the California State Senate from Sacramento whose positions were similar to Downey's, also entered the race.

In January 1950, Douglas opened campaign headquarters in Los Angeles and San Francisco, which was seen as a signal that she was serious about contesting Downey's seat and would not withdraw from the race.
Downey challenged Douglas to a series of debates; Douglas, who was not a good debater, declined.
The two candidates traded charges via press and radio, with Downey describing Douglas's views as extremist.

Douglas's formal campaign launch on February 28 was overshadowed by rumors that Downey might retire, which Douglas called a political maneuver on Downey's part to get the attention of the press.
However, on March 29, amid rumors that he was doing badly in the polls, Downey announced both his retirement and his endorsement of Los Angeles Daily News publisher Manchester Boddy.
In his statement, the senator indicated that, due to his ill health, he was not up to "waging a personal and militant campaign against the vicious and unethical propaganda" of Douglas.

Boddy filed his election paperwork the next day, on the final day petitions were accepted, with his papers signed by Los Angeles Mayor Fletcher Bowron, a Republican, and by Downey campaign manager and 1946 Democratic senatorial candidate Will Rogers, Jr. The publisher had been urged to enter the race by state Democratic leaders and by wealthy oilmen.
He had no political experience; Democratic leaders had sought to draft him to run for the Senate in 1946, but he had declined.
He later stated that his reasons for running were that the race would be a challenge, and that he would meet interesting people.
Boddy, Douglas, and Nixon each "cross-filed", entering both major party primaries.

Douglas called Downey's departure in favor of the publisher a cheap gimmick and made no attempt to reach a rapprochement with the senator, who entered Bethesda Naval Hospital for treatment in early April, and was on sick leave from Congress for several months.
The change in opponents was a mixed blessing for Douglas; it removed the incumbent from the field, but deprived her of the endorsement of the Daily News—one of the few big city papers to consistently support her.
Douglas disregarded advice from party officials to wait until 1952 to run for the Senate, when Republican Senator Knowland would be up for reelection. Fundraising for the campaign was a concern from the beginning; Douglas friend and aide Ed Lybeck wrote her that she would probably need to raise $150,000 ($1.8 million today), which Douglas considered a massive sum. Lybeck wrote,
Now, you can win. You will not be a favorite; you'll be rather a long shot. But given luck and money and a hell of a lot of work, you can win ... but for Christ's sake don't commit suicide with no dough ... Maybe you can't crucify mankind on a cross of gold, but you can sure as hell crucify a statewide candidate upon a cross of no-gold.
On October 5, 1949, Douglas made a radio appearance announcing her candidacy. She attacked Downey almost continuously throughout the remainder of the year, accusing him of being a do-nothing, a tool of big business, and an agent of oil interests. She hired Harold Tipton, a newcomer to California who had managed a successful congressional campaign in the Seattle area, as her campaign manager. Douglas realized that Nixon would most likely be the Republican nominee, and felt that were she to win the primary, the wide gap between Nixon's positions and hers would cause voters to rally to her. Downey, who suffered from a severe ulcer, was initially undecided about running, but announced his candidacy in early December in a speech that included an attack on Douglas. Earl Desmond, a member of the California State Senate from Sacramento whose positions were similar to Downey's, also entered the race.
In January 1950, Douglas opened campaign headquarters in Los Angeles and San Francisco, which was seen as a signal that she was serious about contesting Downey's seat and would not withdraw from the race. Downey challenged Douglas to a series of debates; Douglas, who was not a good debater, declined. The two candidates traded charges via press and radio, with Downey describing Douglas's views as extremist.
Douglas's formal campaign launch on February 28 was overshadowed by rumors that Downey might retire, which Douglas called a political maneuver on Downey's part to get the attention of the press. However, on March 29, amid rumors that he was doing badly in the polls, Downey announced both his retirement and his endorsement of Los Angeles Daily News publisher Manchester Boddy. In his statement, the senator indicated that, due to his ill health, he was not up to "waging a personal and militant campaign against the vicious and unethical propaganda" of Douglas.
Boddy filed his election paperwork the next day, on the final day petitions were accepted, with his papers signed by Los Angeles Mayor Fletcher Bowron, a Republican, and by Downey campaign manager and 1946 Democratic senatorial candidate Will Rogers, Jr. The publisher had been urged to enter the race by state Democratic leaders and by wealthy oilmen. He had no political experience; Democratic leaders had sought to draft him to run for the Senate in 1946, but he had declined. He later stated that his reasons for running were that the race would be a challenge, and that he would meet interesting people. Boddy, Douglas, and Nixon each "cross-filed", entering both major party primaries.
Douglas called Downey's departure in favor of the publisher a cheap gimmick and made no attempt to reach a rapprochement with the senator, who entered Bethesda Naval Hospital for treatment in early April, and was on sick leave from Congress for several months. The change in opponents was a mixed blessing for Douglas; it removed the incumbent from the field, but deprived her of the endorsement of the Daily News—one of the few big city papers to consistently support her.
1950 United States Senate election in California