The first notable funeral Mass offered at St. Matthew's was for Manuel L. Quezon, the president of the Philippines, who died August 1, 1944, and was interred at Arlington National Cemetery until the end of World War II.
In 1957, a Solemn Requiem Mass was offered at the cathedral for the funeral of Senator Joseph McCarthy; the liturgy was attended by 70 senators and hundreds of clergymen and it was filled to capacity.

The cathedral drew worldwide attention following the assassination of United States President John F. Kennedy on Friday, November 22, 1963 in Dallas, Texas.
Richard, Cardinal Cushing, Archbishop of Boston and a Kennedy family friend, offered a recited (not sung) Pontifical Requiem Low Mass during the state funeral on Monday, November 25, 1963 was followed by the procession to Arlington National Cemetery in Virginia for the burial.

Other notable events at the cathedral include a Mass celebrated by Pope John Paul II during his 1979 visit to Washington, D.C., and the 1997 funeral of U.S. Supreme Court Associate Justice William J. Brennan, Jr.
The cathedral was the site of a Lutheran funeral service for Chief Justice William Rehnquist on September 7, 2005.

The funeral of television anchorman Frank Reynolds was held at the cathedral in 1983.
President and Mrs. Reagan were among the 1,100 in attendance on Saturday, July 23, followed by burial at Arlington.

St. Matthew's is the location for one of the most famous Red Masses in the world.
Each year on the day before the term of the Supreme Court of the United States begins, Mass is celebrated to request guidance from the Holy Spirit for the legal profession.
Owing to the Cathedral's location in the nation's capital, the Justices of the Supreme Court, members of Congress and the Cabinet, and many other dignitaries (including, at times, the President of the United States) attend the Mass. Dwight Eisenhower became the first to attend as president in 1954; Harry Truman attended nine years earlier, but as vice president.

In 2020.
St. Matthew's hosted its first Archdiocesan Easter Mass since 1959.
 The mass, televised on EWTN and on livestream, was celebrated by Archbishop Wilton Gregory in front of an empty cathedral.
 The Archdiocese's Easter and Christmas midnight masses, both of which have been televised on EWTN in recent decades, have normally been held at the much larger Basilica of the National Shrine of the Immaculate Conception since it was dedicated in November 1959.
 The reason was the Easter mass was moved back from the Basilica to St. Matthew's for 2020 was due to coronavirus, which kept many churches closed that weekend.
The first notable funeral Mass offered at St. Matthew's was for Manuel L. Quezon, the president of the Philippines, who died August 1, 1944, and was interred at Arlington National Cemetery until the end of World War II. In 1957, a Solemn Requiem Mass was offered at the cathedral for the funeral of Senator Joseph McCarthy; the liturgy was attended by 70 senators and hundreds of clergymen and it was filled to capacity.
The cathedral drew worldwide attention following the assassination of United States President John F. Kennedy on Friday, November 22, 1963 in Dallas, Texas. Richard, Cardinal Cushing, Archbishop of Boston and a Kennedy family friend, offered a recited (not sung) Pontifical Requiem Low Mass during the state funeral on Monday, November 25, 1963 was followed by the procession to Arlington National Cemetery in Virginia for the burial. 
Other notable events at the cathedral include a Mass celebrated by Pope John Paul II during his 1979 visit to Washington, D.C., and the 1997 funeral of U.S. Supreme Court Associate Justice William J. Brennan, Jr.
The cathedral was the site of a Lutheran funeral service for Chief Justice William Rehnquist on September 7, 2005.
The funeral of television anchorman Frank Reynolds was held at the cathedral in 1983. President and Mrs. Reagan were among the 1,100 in attendance on Saturday, July 23, followed by burial at Arlington.
St. Matthew's is the location for one of the most famous Red Masses in the world. Each year on the day before the term of the Supreme Court of the United States begins, Mass is celebrated to request guidance from the Holy Spirit for the legal profession. Owing to the Cathedral's location in the nation's capital, the Justices of the Supreme Court, members of Congress and the Cabinet, and many other dignitaries (including, at times, the President of the United States) attend the Mass. Dwight Eisenhower became the first to attend as president in 1954; Harry Truman attended nine years earlier, but as vice president.
In 2020. St. Matthew's hosted its first Archdiocesan Easter Mass since 1959.  The mass, televised on EWTN and on livestream, was celebrated by Archbishop Wilton Gregory in front of an empty cathedral.  The Archdiocese's Easter and Christmas midnight masses, both of which have been televised on EWTN in recent decades, have normally been held at the much larger Basilica of the National Shrine of the Immaculate Conception since it was dedicated in November 1959.  The reason was the Easter mass was moved back from the Basilica to St. Matthew's for 2020 was due to coronavirus, which kept many churches closed that weekend.
Cathedral of St. Matthew the Apostle (Washington, D.C.)