Cedeño spent his five-season minor league career playing in the Cubs' farm system, reaching the Double-A level in 2004 with the Diamond Jaxx.
In 116 games, he posted a .279 batting average with six home runs and 48 RBI.
He was selected as a midseason Southern League All-Star.

Cedeño was called up in April, 2005, to replace Nomar Garciaparra on the Cubs' roster.
He made big-league debut for the Chicago Cubs on April 23 but spent most of his time on the bench, as Neifi Pérez was awarded the starting job.
After the Cubs signed Enrique Wilson, Cedeño was sent back down to the Triple-A Iowa Cubs.
In 65 games at Iowa in 2005, Cedeño batted an impressive .355, and slugged over .500 for the first time in his professional career.
He returned to the Cubs in June after Wilson was himself sent down to Iowa.
 
Cedeño became the team's starting shortstop in 2006.
He played in 151 games, hit .245, and had 25 errors.
 In 2006, he walked only 3.1% of the time, the lowest percentage in the National League, and 4 of his 17 walks were intentional walks.
He also had the Major League's worst walk/strikeout ratio—0.16.

He played in the 2006 winter league for Venezuela, and averaged .555 in 45 games with 25 runs and 28 RBI.

Cedeño began 2007 with the Major League club on the bench, as the Cubs were set at shortstop and second base with César Izturis and Mark DeRosa.
His offensive struggles continued, batting .118 at the big league level through August, and he spent several more months in Triple-A Iowa.

When the Cubs traded their starting center fielder Jacque Jones in November 2007, general manager Jim Hendry indicated that the club wasn't necessarily looking outside for a veteran, with Cedeño as well as Félix Pie and Sam Fuld in the mix.
 Cedeño was asked to play some center field during the winter.

In 2008, Cedeño made the Major League club out of spring training and spent the entire season with the Cubs, playing primarily off the bench as Reed Johnson and later Jim Edmonds were signed to play center field and Ryan Theriot was ensconced at shortstop.
 As the season progressed, he saw more opportunities to start at second base and shortstop, and got many opportunities off the bench as a pinch hitter and defensive replacement.
 He ended the year hitting .269 with 41 strikeouts in 216 at-bats, making 31 starts at second and 20 at shortstop.
Cedeño spent his five-season minor league career playing in the Cubs' farm system, reaching the Double-A level in 2004 with the Diamond Jaxx. In 116 games, he posted a .279 batting average with six home runs and 48 RBI. He was selected as a midseason Southern League All-Star.
Cedeño was called up in April, 2005, to replace Nomar Garciaparra on the Cubs' roster. He made big-league debut for the Chicago Cubs on April 23 but spent most of his time on the bench, as Neifi Pérez was awarded the starting job. After the Cubs signed Enrique Wilson, Cedeño was sent back down to the Triple-A Iowa Cubs. In 65 games at Iowa in 2005, Cedeño batted an impressive .355, and slugged over .500 for the first time in his professional career. He returned to the Cubs in June after Wilson was himself sent down to Iowa.  
Cedeño became the team's starting shortstop in 2006. He played in 151 games, hit .245, and had 25 errors.  In 2006, he walked only 3.1% of the time, the lowest percentage in the National League, and 4 of his 17 walks were intentional walks. He also had the Major League's worst walk/strikeout ratio—0.16. 
He played in the 2006 winter league for Venezuela, and averaged .555 in 45 games with 25 runs and 28 RBI.
Cedeño began 2007 with the Major League club on the bench, as the Cubs were set at shortstop and second base with César Izturis and Mark DeRosa. His offensive struggles continued, batting .118 at the big league level through August, and he spent several more months in Triple-A Iowa.
When the Cubs traded their starting center fielder Jacque Jones in November 2007, general manager Jim Hendry indicated that the club wasn't necessarily looking outside for a veteran, with Cedeño as well as Félix Pie and Sam Fuld in the mix.  Cedeño was asked to play some center field during the winter.
In 2008, Cedeño made the Major League club out of spring training and spent the entire season with the Cubs, playing primarily off the bench as Reed Johnson and later Jim Edmonds were signed to play center field and Ryan Theriot was ensconced at shortstop.  As the season progressed, he saw more opportunities to start at second base and shortstop, and got many opportunities off the bench as a pinch hitter and defensive replacement.  He ended the year hitting .269 with 41 strikeouts in 216 at-bats, making 31 starts at second and 20 at shortstop.
Ronny Cedeño