The park is located on either side of the mouth of the Sanaga River along the shores of the Bight of Biafra opposite the island of Bioko.
Lake Tissongo, a lagoon connected to the south bank of the Sanaga River by a 5 kilometres (3.1 mi) tidal channel, is included in the reserve.

Mouanko is the main town in the reserve, on the north shore of the Sanaga River.
The park is located on either side of the mouth of the Sanaga River along the shores of the Bight of Biafra opposite the island of Bioko. Lake Tissongo, a lagoon connected to the south bank of the Sanaga River by a 5 kilometres (3.1 mi) tidal channel, is included in the reserve.
Mouanko is the main town in the reserve, on the north shore of the Sanaga River.
Douala Edéa National Park