If the Laghman II inscription in Afghanistan is referring to Palmyra, then the city's role in Central Asian overland trade was prominent as early as the third century BC.
During the first centuries AD, Palmyra's main trade route ran east to the Euphrates where it connected at the city of Hīt.
The route then ran south along the river toward the port of Charax Spasinu on the Persian Gulf, where Palmyrene ships traveled back and forth to India.
Goods were imported from India, China and Transoxiana, and exported west to Emesa (or Antioch) then the Mediterranean ports, from which they were distributed throughout the Roman Empire.
In addition to the usual route some Palmyrene merchants used the Red Sea, probably as a result of the Roman–Parthian Wars.
Goods were carried overland from the seaports to a Nile port, and then taken to the Egyptian Mediterranean ports for export.
Inscriptions attesting a Palmyrene presence in Egypt date to the reign of Hadrian.

Since Palmyra was not on the main trading route (which followed the Euphrates), the Palmyrenes secured the desert route passing their city.
They connected it to the Euphrates valley, providing water and shelter.
The Palmyrene route connected the Silk Road with the Mediterranean, and was used almost exclusively by the city's merchants, who maintained a presence in many cities, including Dura-Europos in 33 BC, Babylon by AD 19, Seleucia by AD 24, Dendera, Coptos, Bahrain, the Indus River Delta, Merv and Rome.

The caravan trade depended on patrons and merchants.
Patrons owned the land on which the caravan animals were raised, providing animals and guards for the merchants.
The lands were located in the numerous villages of the Palmyrene countryside.
Although merchants used the patrons to conduct business, their roles often overlapped and a patron would sometimes lead a caravan.
Commerce made Palmyra and its merchants among the wealthiest in the region.
Some caravans were financed by a single merchant, such as Male' Agrippa (who financed Hadrian's visit in 129 and the 139 rebuilding of the Temple of Bel).
The primary income-generating trade good was silk, which was exported from the East to the West.
Other exported goods included jade, muslin, spices, ebony, ivory and precious stones.
For its domestic market Palmyra imported a variety of goods including slaves, prostitutes, olive oil, dyed goods, myrrh and perfume.
If the Laghman II inscription in Afghanistan is referring to Palmyra, then the city's role in Central Asian overland trade was prominent as early as the third century BC. During the first centuries AD, Palmyra's main trade route ran east to the Euphrates where it connected at the city of Hīt. The route then ran south along the river toward the port of Charax Spasinu on the Persian Gulf, where Palmyrene ships traveled back and forth to India. Goods were imported from India, China and Transoxiana, and exported west to Emesa (or Antioch) then the Mediterranean ports, from which they were distributed throughout the Roman Empire. In addition to the usual route some Palmyrene merchants used the Red Sea, probably as a result of the Roman–Parthian Wars. Goods were carried overland from the seaports to a Nile port, and then taken to the Egyptian Mediterranean ports for export. Inscriptions attesting a Palmyrene presence in Egypt date to the reign of Hadrian.
Since Palmyra was not on the main trading route (which followed the Euphrates), the Palmyrenes secured the desert route passing their city. They connected it to the Euphrates valley, providing water and shelter. The Palmyrene route connected the Silk Road with the Mediterranean, and was used almost exclusively by the city's merchants, who maintained a presence in many cities, including Dura-Europos in 33 BC, Babylon by AD 19, Seleucia by AD 24, Dendera, Coptos, Bahrain, the Indus River Delta, Merv and Rome.
The caravan trade depended on patrons and merchants. Patrons owned the land on which the caravan animals were raised, providing animals and guards for the merchants. The lands were located in the numerous villages of the Palmyrene countryside. Although merchants used the patrons to conduct business, their roles often overlapped and a patron would sometimes lead a caravan. Commerce made Palmyra and its merchants among the wealthiest in the region. Some caravans were financed by a single merchant, such as Male' Agrippa (who financed Hadrian's visit in 129 and the 139 rebuilding of the Temple of Bel). The primary income-generating trade good was silk, which was exported from the East to the West. Other exported goods included jade, muslin, spices, ebony, ivory and precious stones. For its domestic market Palmyra imported a variety of goods including slaves, prostitutes, olive oil, dyed goods, myrrh and perfume.
Palmyra