The College of Physicians of Philadelphia Building is a two-story rectangular red brick structure with limestone trim that was completed in 1909.
Many of its forms are drawn from London's Royal College of Physicians, designed by Robert Hooke and built in 1673–77.
 The building houses the library, a lecture hall, the museum, and offices.
 Three facades are highly decorated – the main facade on South 22nd Street facing west, the northern facade facing Ludlow Street, and the southern facade facing a courtyard.
Three broad horizontal bands of limestone – along the basement, at the top of the first floor, and the balustrade – artistically unite all the facades.

The 22nd Street facade is most richly ornamented with a grand entrance behind a monumental gate and a wrought iron fence.
The entrance is classically composed, flanked by Roman Doric columns with richly carved capitals.
Outside this pair of columns are two pilasters, carved with the seal of the College of Physicians, that support a Doric entablature.

The interior is an opulent example of the Beaux-Arts architecture.
A 30-foot-wide (9.1 m) octagonal rotunda, the main hall, and a rich formal marble stair form the central axis, with the main rooms branching off this axis.
The stair, which dominates the first story, has a bronze railing and a niche holding a sculpture of Aesculapius, the god of healing.
Mitchell Hall, originally called the Hall of Portraits, is a grand ceremonial hall measuring 71 by 48 feet (15 m).
 It holds much of the College's art collection, including works by Robert Vonnoh and William Merritt Chase.
The Norris Room contains an unusual carved stone Gothic fireplace designed by Theophilus Parsons Chandler, Jr. The fireplace was donated in 1885 by George William Childs, publisher of the Philadelphia Public Ledger, and originally built in the College's old Locust Street building.
The Mütter Museum is a two-storied space surrounded by a gallery in the northeast corner of the building,
The College of Physicians of Philadelphia Building is a two-story rectangular red brick structure with limestone trim that was completed in 1909. Many of its forms are drawn from London's Royal College of Physicians, designed by Robert Hooke and built in 1673–77.  The building houses the library, a lecture hall, the museum, and offices.  Three facades are highly decorated – the main facade on South 22nd Street facing west, the northern facade facing Ludlow Street, and the southern facade facing a courtyard. Three broad horizontal bands of limestone – along the basement, at the top of the first floor, and the balustrade – artistically unite all the facades.
The 22nd Street facade is most richly ornamented with a grand entrance behind a monumental gate and a wrought iron fence. The entrance is classically composed, flanked by Roman Doric columns with richly carved capitals. Outside this pair of columns are two pilasters, carved with the seal of the College of Physicians, that support a Doric entablature.
The interior is an opulent example of the Beaux-Arts architecture. A 30-foot-wide (9.1 m) octagonal rotunda, the main hall, and a rich formal marble stair form the central axis, with the main rooms branching off this axis. The stair, which dominates the first story, has a bronze railing and a niche holding a sculpture of Aesculapius, the god of healing. Mitchell Hall, originally called the Hall of Portraits, is a grand ceremonial hall measuring 71 by 48 feet (15 m).  It holds much of the College's art collection, including works by Robert Vonnoh and William Merritt Chase. The Norris Room contains an unusual carved stone Gothic fireplace designed by Theophilus Parsons Chandler, Jr. The fireplace was donated in 1885 by George William Childs, publisher of the Philadelphia Public Ledger, and originally built in the College's old Locust Street building. The Mütter Museum is a two-storied space surrounded by a gallery in the northeast corner of the building,
College of Physicians of Philadelphia