Chicago is the largest economic and financial center.
Chicago was named the fourth most important business center in the world in the MasterCard Worldwide Centers of Commerce Index.
The 2017 Global Financial Centres Index ranked Chicago as the fifth most competitive city in the country and twenty-fourth in the world.
The Chicago Board of Trade (established 1848) listed the first ever standardized "exchange traded" forward contracts, which were called futures contracts.
 As a world financial center it is home to major financial and futures exchanges, including the Chicago Stock Exchange, the Chicago Board Options Exchange (CBOE), and the Chicago Mercantile Exchange (the "Merc"), which is owned, along with the Chicago Board of Trade (CBOT) by Chicago's CME Group.
The CME Group, in addition, owns the New York Mercantile Exchange (NYMEX), the Commodities Exchange Inc. (COMEX), and the Dow Jones Indexes, as well as headquarters of the Federal Reserve Bank of Chicago (the Seventh District of the Federal Reserve).

Toronto is an international centre for business and finance.
Generally considered the financial capital of Canada, Toronto has a high concentration of banks and brokerage firms on Bay Street, in the Financial District.
The Toronto Stock Exchange is the world's seventh-largest stock exchange by market capitalization.
The five largest financial institutions of Canada, collectively known as the Big Five, have national offices in Toronto.

Outside of Chicago and Toronto, many other cities are host to financial centers as well.
Major bank headquarters are located in Ohio including Huntington Bancshares in Columbus, Fifth Third Bank in Cincinnati, and KeyCorp in Cleveland.
Insurance Companies such as Anthem in Indianapolis, Nationwide Insurance in Columbus, American Family Insurance in Madison, Wisconsin, Berkshire Hathaway in Omaha, State Farm Insurance in Bloomington, Illinois, and Progressive Insurance and Medical Mutual of Ohio in Cleveland.
Chicago is the largest economic and financial center. Chicago was named the fourth most important business center in the world in the MasterCard Worldwide Centers of Commerce Index. The 2017 Global Financial Centres Index ranked Chicago as the fifth most competitive city in the country and twenty-fourth in the world. The Chicago Board of Trade (established 1848) listed the first ever standardized "exchange traded" forward contracts, which were called futures contracts.  As a world financial center it is home to major financial and futures exchanges, including the Chicago Stock Exchange, the Chicago Board Options Exchange (CBOE), and the Chicago Mercantile Exchange (the "Merc"), which is owned, along with the Chicago Board of Trade (CBOT) by Chicago's CME Group. The CME Group, in addition, owns the New York Mercantile Exchange (NYMEX), the Commodities Exchange Inc. (COMEX), and the Dow Jones Indexes, as well as headquarters of the Federal Reserve Bank of Chicago (the Seventh District of the Federal Reserve).
Toronto is an international centre for business and finance. Generally considered the financial capital of Canada, Toronto has a high concentration of banks and brokerage firms on Bay Street, in the Financial District. The Toronto Stock Exchange is the world's seventh-largest stock exchange by market capitalization.The five largest financial institutions of Canada, collectively known as the Big Five, have national offices in Toronto. 
Outside of Chicago and Toronto, many other cities are host to financial centers as well. Major bank headquarters are located in Ohio including Huntington Bancshares in Columbus, Fifth Third Bank in Cincinnati, and KeyCorp in Cleveland. Insurance Companies such as Anthem in Indianapolis, Nationwide Insurance in Columbus, American Family Insurance in Madison, Wisconsin, Berkshire Hathaway in Omaha, State Farm Insurance in Bloomington, Illinois, and Progressive Insurance and Medical Mutual of Ohio in Cleveland.
Great Lakes region