According to some sources the site of present-day Druskininkai was inhabited by local Yotvingian tribes in the early Middle Ages.
In the 13th century the area became a part of the expanding Duchy of Lithuania.
A small castle was built in the area as a part of the defence system against the Teutonic Order.
In 1308 the castle was conquered by the Teutonic Knights and destroyed, causing a depopulation of the area.

The first written mention of  Druskininkai dates back to 1636.
The name of the town suggests that the local population collected precious minerals.
In the late 18th century it was believed that minerals found in the waters of Druskininkai area produced health benefits and their usage in the medical treatment of asthma and other ailments began.
In the early 19th century Ignacy Fonberger, a professor at the University of Vilnius, analyzed the chemical composition of Druskininkai's waters and showed that they contain large amounts of Calcium, Sodium, Potassium, Iodine, Bromine, Iron and Magnesium.
He also promoted the town as a holiday resort for the population of Vilnius.

In 1837 Tsar Nicholas I of Russia bestowed upon Druskininkai the status of a spa, and construction of pensions and hostels started.
To ease communication to the spa, a ferry service on the Nemunas was started.

The spa became popular in many parts of the former Polish–Lithuanian Commonwealth.
In 1862 the Warsaw – Saint Petersburg Railway was opened and Druskininkai's railway station was placed only 19 kilometres (12 miles) from the city.

In June 1887, a Jewish national conference was held in Druskininkai led by Leon Pinsker and Moses Lilienblum which discussed ideas that played an important role in the development of the Zionist movement.

By the beginning of the 20th century the Druskininkai spa was one of the most popular resorts in the area and a place of summer residence for the middle class of Vilnius, Warsaw and Moscow.

After World War I the town became part of Poland (see Polish-Lithuanian conflict).
Its popularity was increased by the patronage of Józef Piłsudski, who spent most of his summer holidays there and promoted the development of the area.
Soon most of the resort was bought up by the state-owned Bank Gospodarstwa Krajowego and the construction of luxurious villas and pensions started.
In 1934 a railway link with the Parečča train station was opened and the town became more accessible to the general public.
It was a gmina center in Grodno powiat of Białystok Voivodeship.
According to some sources the site of present-day Druskininkai was inhabited by local Yotvingian tribes in the early Middle Ages. In the 13th century the area became a part of the expanding Duchy of Lithuania. A small castle was built in the area as a part of the defence system against the Teutonic Order. In 1308 the castle was conquered by the Teutonic Knights and destroyed, causing a depopulation of the area.
The first written mention of  Druskininkai dates back to 1636. The name of the town suggests that the local population collected precious minerals. In the late 18th century it was believed that minerals found in the waters of Druskininkai area produced health benefits and their usage in the medical treatment of asthma and other ailments began. In the early 19th century Ignacy Fonberger, a professor at the University of Vilnius, analyzed the chemical composition of Druskininkai's waters and showed that they contain large amounts of Calcium, Sodium, Potassium, Iodine, Bromine, Iron and Magnesium. He also promoted the town as a holiday resort for the population of Vilnius.
In 1837 Tsar Nicholas I of Russia bestowed upon Druskininkai the status of a spa, and construction of pensions and hostels started. To ease communication to the spa, a ferry service on the Nemunas was started.
The spa became popular in many parts of the former Polish–Lithuanian Commonwealth. In 1862 the Warsaw – Saint Petersburg Railway was opened and Druskininkai's railway station was placed only 19 kilometres (12 miles) from the city.
In June 1887, a Jewish national conference was held in Druskininkai led by Leon Pinsker and Moses Lilienblum which discussed ideas that played an important role in the development of the Zionist movement.
By the beginning of the 20th century the Druskininkai spa was one of the most popular resorts in the area and a place of summer residence for the middle class of Vilnius, Warsaw and Moscow.
After World War I the town became part of Poland (see Polish-Lithuanian conflict). Its popularity was increased by the patronage of Józef Piłsudski, who spent most of his summer holidays there and promoted the development of the area. Soon most of the resort was bought up by the state-owned Bank Gospodarstwa Krajowego and the construction of luxurious villas and pensions started. In 1934 a railway link with the Parečča train station was opened and the town became more accessible to the general public. It was a gmina center in Grodno powiat of Białystok Voivodeship.
Druskininkai