Khafra was a son of king Khufu and the brother and successor of Djedefre.
Khafra is thought by some to be the son of Queen Meritites I due to an inscription where he is said to honor her memory.

Kings-wife, his beloved, devoted to Horus, Mertitytes.


King's-wife, his beloved, Mertitytes; beloved of the Favorite of

the Two Goddesses; she who says anything whatsoever and it is done

for her.
 Great in the favor of Snefr[u] ; great in the favor

of Khuf[u], devoted to Horus, honored under Khafre.
Merti[tyt]es.

[Breasted; Ancient Records]
Others argue that the inscription just suggests that this queen died during the reign of Khafre.
 Khafre may be a son of Queen Henutsen instead.

Khafra had several wives and he had at least 12 sons and 3 or 4 daughters.

Queen Meresankh III was the daughter of Kawab and Hetepheres II and thus a niece of Khafra.
She was the mother of Khafra's sons Nebemakhet, Duaenre, Niuserre and Khentetka, and a daughter named Shepsetkau.

Queen Khamerernebty I was the mother of Menkaure and his principal queen Khamerernebty II.

Hekenuhedjet was a wife of Khafra.
She is mentioned in the tomb of her son Sekhemkare.

Persenet may have been a wife of Khafra based on the location of her tomb.
She was the mother of Nikaure.

Other children of Khafra are known, but no mothers have been identified.
Further sons include Ankhmare, Akhre, Iunmin, and Iunre.
Two more daughters named Rekhetre and Hemetre are known as well.
Khafra was a son of king Khufu and the brother and successor of Djedefre. Khafra is thought by some to be the son of Queen Meritites I due to an inscription where he is said to honor her memory.
Kings-wife, his beloved, devoted to Horus, Mertitytes.

King's-wife, his beloved, Mertitytes; beloved of the Favorite of

the Two Goddesses; she who says anything whatsoever and it is done

for her.  Great in the favor of Snefr[u] ; great in the favor

of Khuf[u], devoted to Horus, honored under Khafre. Merti[tyt]es.
[Breasted; Ancient Records]
Others argue that the inscription just suggests that this queen died during the reign of Khafre.  Khafre may be a son of Queen Henutsen instead.
Khafra had several wives and he had at least 12 sons and 3 or 4 daughters. 
Queen Meresankh III was the daughter of Kawab and Hetepheres II and thus a niece of Khafra. She was the mother of Khafra's sons Nebemakhet, Duaenre, Niuserre and Khentetka, and a daughter named Shepsetkau.
Queen Khamerernebty I was the mother of Menkaure and his principal queen Khamerernebty II.
Hekenuhedjet was a wife of Khafra. She is mentioned in the tomb of her son Sekhemkare.
Persenet may have been a wife of Khafra based on the location of her tomb. She was the mother of Nikaure.
Other children of Khafra are known, but no mothers have been identified. Further sons include Ankhmare, Akhre, Iunmin, and Iunre. Two more daughters named Rekhetre and Hemetre are known as well.
Khafra