Moss had a supporting role in the 2005–2006 horror series Invasion, and appeared in television again on a 2007 episode of Grey's Anatomy entitled "My Favorite Mistake", and on the series Medium opposite Patricia Arquette.
She also appeared in Mary Lambert's 2007 horror film The Attic, and the independent drama Day Zero (2007).

In 2006, she was cast as Peggy Olson, secretary-turned-copywriter in the AMC dramatic series Mad Men.
Between 2009 and the series' final season in 2015, Moss was nominated for five Emmy awards for the role for Outstanding Lead Actress in a Drama Series.
In 2010, she was nominated for the Outstanding Supporting Actress Emmy.
Reflecting on her casting in the series, Moss recalled: "I auditioned [for the role].
There were scripts for two pilots that everyone was talking about at the time that were really good, and Mad Men was one of them."

While a series regular on Mad Men, Moss made her Broadway debut in October 2008, playing the role of Karen in the 20th Anniversary revival of Speed-the-Plow by David Mamet.
She then briefly appeared in the comedy film Did You Hear About the Morgans? (
2009), playing Sarah Jessica Parker's assistant, followed by a part in the comedy Get Him to the Greek (2010) opposite Jonah Hill.

In 2011, Moss made her West End debut as Martha Dobie in Lillian Hellman's play The Children's Hour, opposite Keira Knightley.
The play opened at The Comedy Theatre, London on January 22, 2011.
In 2012, she was cast as Galatea Dunkel in the independent drama On the Road, based on Jack Kerouac's novel of the same name.

Moss played detective Robin Griffin in the 2013 Sundance Channel miniseries Top of the Lake, a co-production by the Sundance Channel, the UK's BBC Two and Australia's UKTV, written and directed by Oscar-winner Jane Campion.
For her role, Moss received the Golden Globe Award for Best Actress – Miniseries or Television Film.
In 2014, Moss starred in the independent film Listen Up Philip (2014), her first collaboration with writer-director Alex Ross Perry.
She also starred in Charlie McDowell's The One I Love (2014) with Mark Duplass.
Moss had a supporting role in the 2005–2006 horror series Invasion, and appeared in television again on a 2007 episode of Grey's Anatomy entitled "My Favorite Mistake", and on the series Medium opposite Patricia Arquette. She also appeared in Mary Lambert's 2007 horror film The Attic, and the independent drama Day Zero (2007).
In 2006, she was cast as Peggy Olson, secretary-turned-copywriter in the AMC dramatic series Mad Men. Between 2009 and the series' final season in 2015, Moss was nominated for five Emmy awards for the role for Outstanding Lead Actress in a Drama Series. In 2010, she was nominated for the Outstanding Supporting Actress Emmy. Reflecting on her casting in the series, Moss recalled: "I auditioned [for the role]. There were scripts for two pilots that everyone was talking about at the time that were really good, and Mad Men was one of them."
While a series regular on Mad Men, Moss made her Broadway debut in October 2008, playing the role of Karen in the 20th Anniversary revival of Speed-the-Plow by David Mamet. She then briefly appeared in the comedy film Did You Hear About the Morgans? (2009), playing Sarah Jessica Parker's assistant, followed by a part in the comedy Get Him to the Greek (2010) opposite Jonah Hill.
In 2011, Moss made her West End debut as Martha Dobie in Lillian Hellman's play The Children's Hour, opposite Keira Knightley. The play opened at The Comedy Theatre, London on January 22, 2011. In 2012, she was cast as Galatea Dunkel in the independent drama On the Road, based on Jack Kerouac's novel of the same name.
Moss played detective Robin Griffin in the 2013 Sundance Channel miniseries Top of the Lake, a co-production by the Sundance Channel, the UK's BBC Two and Australia's UKTV, written and directed by Oscar-winner Jane Campion. For her role, Moss received the Golden Globe Award for Best Actress – Miniseries or Television Film. In 2014, Moss starred in the independent film Listen Up Philip (2014), her first collaboration with writer-director Alex Ross Perry. She also starred in Charlie McDowell's The One I Love (2014) with Mark Duplass.
Elisabeth Moss