Ordell Braase, former NFL player and broadcaster
Israel Greene, adjutant of the Confederate Marine Corps
James S. Hyde, biophysicist
Dusty Johnson, US Congressman, former PUC Commissioner, and chief of staff to the Governor
John Bailey Jones, retired United States federal judge
Mike Miller, former NBA basketball player, was 2000-01 NBA Rookie of the Year, 2005–06 NBA Sixth Man of the Year Award winner and a two-time NBA champion.

George McGovern, former Representative and Senator from South Dakota and 1972 Democratic nominee for President, grew up in Mitchell, and lived there until his death in 2012.

Adam Morrison, basketball player, briefly lived in Mitchell as a young child while his father was coaching at Dakota Wesleyan.

Gary Owens, voice actor and Disc Jockey
David Rumelhart, Cognitive Psychologist who co-developed key neural network AI method Backpropagation with Geoffrey Hinton and Ronald J. Williams
Howard Rushmore, journalist and investigative reporter
Ordell Braase, former NFL player and broadcaster
Israel Greene, adjutant of the Confederate Marine Corps
James S. Hyde, biophysicist
Dusty Johnson, US Congressman, former PUC Commissioner, and chief of staff to the Governor
John Bailey Jones, retired United States federal judge
Mike Miller, former NBA basketball player, was 2000-01 NBA Rookie of the Year, 2005–06 NBA Sixth Man of the Year Award winner and a two-time NBA champion.
George McGovern, former Representative and Senator from South Dakota and 1972 Democratic nominee for President, grew up in Mitchell, and lived there until his death in 2012.
Adam Morrison, basketball player, briefly lived in Mitchell as a young child while his father was coaching at Dakota Wesleyan.
Gary Owens, voice actor and Disc Jockey
David Rumelhart, Cognitive Psychologist who co-developed key neural network AI method Backpropagation with Geoffrey Hinton and Ronald J. Williams
Howard Rushmore, journalist and investigative reporter
Mitchell, South Dakota