cTnI has diverged from the skeletal muscle isoforms of TnI (slow TnI and fast TnI) mainly with a unique N-terminal extension.
The amino acid sequence of cTnI is strongly conserved among mammalian species (Fig.
1).
On the other hand, the N-terminal extension of cTnI has significantly different structures among mammal, amphibian and fish.
cTnI has diverged from the skeletal muscle isoforms of TnI (slow TnI and fast TnI) mainly with a unique N-terminal extension. The amino acid sequence of cTnI is strongly conserved among mammalian species (Fig. 1). On the other hand, the N-terminal extension of cTnI has significantly different structures among mammal, amphibian and fish.
TNNI3