In a 28–0 win over Kentucky State College to open the season, Owsley Manier scored three touchdowns and the Commodores as a whole rushed for 630 yards.
G. A. Hall had a 33-yard punt return for a touchdown.
The Commodores were penalized several times.
Kentucky never had a first down and had to punt after second down.

The starting lineup was: Stone (left end); Pritchard (left tackle); King (left guard); Wynne (center); Sherrill (right guard); E. Noel (right tackle); B. Blake (right end); Costen (quarterback); Crawford (left halfback); Craig (right halfback); Manier (fullback).
In a 28–0 win over Kentucky State College to open the season, Owsley Manier scored three touchdowns and the Commodores as a whole rushed for 630 yards. G. A. Hall had a 33-yard punt return for a touchdown. The Commodores were penalized several times. Kentucky never had a first down and had to punt after second down.
The starting lineup was: Stone (left end); Pritchard (left tackle); King (left guard); Wynne (center); Sherrill (right guard); E. Noel (right tackle); B. Blake (right end); Costen (quarterback); Crawford (left halfback); Craig (right halfback); Manier (fullback).
1906 Vanderbilt Commodores football team