After moving to Houston, the de Menils quickly became key figures in the city's developing cultural life as advocates of modern art and architecture.
In 1949 they commissioned the architect Philip Johnson to design their home in the River Oaks neighborhood in Houston.
One of the first International Style residences in Texas, it generated controversy not only by standing out amongst the mansions of River Oaks but also by pairing Johnson's clean, modernist lines with a bold color palette and eclectic interior design by Charles James.
The de Menils filled their home with art and hosted many of the leading artists, scientists, civil rights activists, and intellectuals of the day.

Spurred in part by the lack of a real arts community in Houston, in the 1950s and 1960s the de Menils promoted modern art through exhibitions held at the Contemporary Arts Association (later the Contemporary Arts Museum Houston), such as Max Ernst's first solo exhibition in the United States, and the Museum of Fine Arts, Houston, to which they gave important gifts of art.
They were instrumental in the Contemporary Arts Association's decision to hire Jermayne MacAgy as its director; she curated several groundbreaking exhibitions, including "The Sphere of Mondrian" and "Totems Not Taboo: An Exhibition of Primitive Art."
In 1954 they founded the Menil Foundation, a non-profit organization dedicated to the "support and advancement of religious, charitable, literary, scientific and educational purposes."

That same year they provided the University of St. Thomas, a small Catholic institution in Houston, with funding to build Strake Hall and Jones Hall, designed by Philip Johnson per their recommendation.
In an effort to provide a strong art history curriculum in Houston for students and adults, they founded the Art Department at the University of St. Thomas in 1959, inviting Jermayne MacAgy to teach courses and curate exhibitions held at Jones Hall.
They established the university's Media Center in 1967.
The de Menils often personally recruited faculty members for the departments and brought many renowned artists and art historians to Houston, including Marcel Duchamp, Roberto Matta, and James Johnson Sweeney, whom they convinced to serve as museum director for the Museum of Fine Arts, Houston from 1961 to 1967.
After Jermayne MacAgy's death in 1964, de Menil took over her classes and became the chairperson of the Art Department at the University of St. Thomas, curating several exhibitions over the next few years.

After being met with increasing resistance by the more traditional Basilian clergy at the University of St. Thomas, in 1969 the de Menils moved the Art Department—including the art history faculty—and Media Center to Rice University, where they founded the Institute for the Arts to manage the exhibition program at Rice Museum.
Notable exhibitions at Rice Museum organized with the help of the de Menils were "The Machine as Seen at the End of the Mechanical Age", curated by Pontus Hulten for the Museum of Modern Art, New York, and "Raid the Icebox 1 with Andy Warhol", an exhibition of objects selected by Warhol from the storage vaults of the Museum of Art at Rhode Island School of Design.
 At Rice the de Menils also cultivated their interest in film, working with such noted filmmakers as Roberto Rossellini, who made several trips to Houston to teach Rice University students and create television documentaries.
The de Menils supported Rice University Professor of Astrophysics, Donald D. Clayton for a two-week residence in Rome in June–July 1970 for daily work with Rossellini  conceiving a film about cosmology that did not advance to filming but that was published in 1975 as a personal memoir of a life discovering our universe.
Other filmmakers who visited the Media Center included Ola Balogun, Bernardo Bertolucci, James Blue, Jim McBride, and Colin Young.

John and Dominique de Menil also shared an interest in photography, inviting photographers to come to Houston to document events in the city and exhibit their work.
They commissioned Henri Cartier
After moving to Houston, the de Menils quickly became key figures in the city's developing cultural life as advocates of modern art and architecture. In 1949 they commissioned the architect Philip Johnson to design their home in the River Oaks neighborhood in Houston. One of the first International Style residences in Texas, it generated controversy not only by standing out amongst the mansions of River Oaks but also by pairing Johnson's clean, modernist lines with a bold color palette and eclectic interior design by Charles James. The de Menils filled their home with art and hosted many of the leading artists, scientists, civil rights activists, and intellectuals of the day.
Spurred in part by the lack of a real arts community in Houston, in the 1950s and 1960s the de Menils promoted modern art through exhibitions held at the Contemporary Arts Association (later the Contemporary Arts Museum Houston), such as Max Ernst's first solo exhibition in the United States, and the Museum of Fine Arts, Houston, to which they gave important gifts of art. They were instrumental in the Contemporary Arts Association's decision to hire Jermayne MacAgy as its director; she curated several groundbreaking exhibitions, including "The Sphere of Mondrian" and "Totems Not Taboo: An Exhibition of Primitive Art." In 1954 they founded the Menil Foundation, a non-profit organization dedicated to the "support and advancement of religious, charitable, literary, scientific and educational purposes."
That same year they provided the University of St. Thomas, a small Catholic institution in Houston, with funding to build Strake Hall and Jones Hall, designed by Philip Johnson per their recommendation. In an effort to provide a strong art history curriculum in Houston for students and adults, they founded the Art Department at the University of St. Thomas in 1959, inviting Jermayne MacAgy to teach courses and curate exhibitions held at Jones Hall. They established the university's Media Center in 1967. The de Menils often personally recruited faculty members for the departments and brought many renowned artists and art historians to Houston, including Marcel Duchamp, Roberto Matta, and James Johnson Sweeney, whom they convinced to serve as museum director for the Museum of Fine Arts, Houston from 1961 to 1967. After Jermayne MacAgy's death in 1964, de Menil took over her classes and became the chairperson of the Art Department at the University of St. Thomas, curating several exhibitions over the next few years.
After being met with increasing resistance by the more traditional Basilian clergy at the University of St. Thomas, in 1969 the de Menils moved the Art Department—including the art history faculty—and Media Center to Rice University, where they founded the Institute for the Arts to manage the exhibition program at Rice Museum. Notable exhibitions at Rice Museum organized with the help of the de Menils were "The Machine as Seen at the End of the Mechanical Age", curated by Pontus Hulten for the Museum of Modern Art, New York, and "Raid the Icebox 1 with Andy Warhol", an exhibition of objects selected by Warhol from the storage vaults of the Museum of Art at Rhode Island School of Design.  At Rice the de Menils also cultivated their interest in film, working with such noted filmmakers as Roberto Rossellini, who made several trips to Houston to teach Rice University students and create television documentaries. The de Menils supported Rice University Professor of Astrophysics, Donald D. Clayton for a two-week residence in Rome in June–July 1970 for daily work with Rossellini  conceiving a film about cosmology that did not advance to filming but that was published in 1975 as a personal memoir of a life discovering our universe. Other filmmakers who visited the Media Center included Ola Balogun, Bernardo Bertolucci, James Blue, Jim McBride, and Colin Young.
John and Dominique de Menil also shared an interest in photography, inviting photographers to come to Houston to document events in the city and exhibit their work. They commissioned Henri Cartier
Dominique de Menil