In Week 1 against the Tampa Bay Buccaneers, Sherman intercepted a pass thrown by Jameis Winston and returned it 37 yards for a touchdown in the 31–17 win.
This was Sherman's first interception and touchdown as a member of the 49ers.

In week 5 against the Cleveland Browns, Sherman recorded an interception off Baker Mayfield in the 31–3 win.

In week 8 against the Carolina Panthers, Sherman recorded his third interception of the season off Kyle Allen in the 51–13 win.
On December 17, Sherman was selected to his 5th Pro Bowl, his first with the 49ers and first since 2016 with the Seahawks.
Sherman was voted on the AP 2nd Team All-Pro, his first All-Pro appearance since 2015 and fifth overall.

In the Divisional Round of the playoffs against the Minnesota Vikings, Sherman intercepted a pass thrown by Kirk Cousins and returned it for 13 yards during the 27–10 win.
In the NFC Championship Game against the Green Bay Packers, Sherman recorded 2 tackles and picked off Aaron Rodgers in the final two minutes of the game which sealed a 37–20 win and a trip to Super Bowl LIV.

However, Sherman's bid for a second Lombardi Trophy came to an end in Miami Gardens, Florida, as the 49ers were defeated 31-20 by the Kansas City Chiefs, in a game in which Sherman missed an important tackle on Damien Williams, which was ruled a touchdown, and gave the Chiefs a 24-20 lead with under 3 minutes to play.
Sherman was also criticized for giving up a 38-yard reception by wide receiver Sammy Watkins in the Chiefs game-winning touchdown drive.
In Week 1 against the Tampa Bay Buccaneers, Sherman intercepted a pass thrown by Jameis Winston and returned it 37 yards for a touchdown in the 31–17 win. This was Sherman's first interception and touchdown as a member of the 49ers.
In week 5 against the Cleveland Browns, Sherman recorded an interception off Baker Mayfield in the 31–3 win.
In week 8 against the Carolina Panthers, Sherman recorded his third interception of the season off Kyle Allen in the 51–13 win. On December 17, Sherman was selected to his 5th Pro Bowl, his first with the 49ers and first since 2016 with the Seahawks. Sherman was voted on the AP 2nd Team All-Pro, his first All-Pro appearance since 2015 and fifth overall.
In the Divisional Round of the playoffs against the Minnesota Vikings, Sherman intercepted a pass thrown by Kirk Cousins and returned it for 13 yards during the 27–10 win. In the NFC Championship Game against the Green Bay Packers, Sherman recorded 2 tackles and picked off Aaron Rodgers in the final two minutes of the game which sealed a 37–20 win and a trip to Super Bowl LIV.
However, Sherman's bid for a second Lombardi Trophy came to an end in Miami Gardens, Florida, as the 49ers were defeated 31-20 by the Kansas City Chiefs, in a game in which Sherman missed an important tackle on Damien Williams, which was ruled a touchdown, and gave the Chiefs a 24-20 lead with under 3 minutes to play. Sherman was also criticized for giving up a 38-yard reception by wide receiver Sammy Watkins in the Chiefs game-winning touchdown drive.
Richard Sherman (American football)