Nelson was thought to be in danger of losing his seat in 2006, as it was thought his successor as governor, Mike Johanns, was almost certain to run against him; that speculation ended when Johanns was appointed U.S. Secretary of Agriculture.
With Johanns's move to Washington, few high-profile Republicans stepped up to run against Nelson, as the state party focused its attention on the governor's race.
The Republican nomination was won by Pete Ricketts, a former TD Ameritrade executive.

In the general election, Nelson was endorsed by the National Rifle Association, Nebraska Right to Life (National Right to Life's state affiliate), Nebraskans United for Life, the U.S. Chamber of Commerce, the National Federation of Independent Businesses, Nebraska Farmers Union PAC, National Farmers Union PAC, the Veterans of Foreign Wars PAC, the Business-Industry Political Action Committee, and the Omaha Police Union, all conservative-leaning groups.

Nelson defeated Ricketts 64%-36%, the biggest victory margin for a Democratic Senate candidate in Nebraska since Edward Zorinsky won 66% of the vote in 1982.
In doing so, he received the votes of 42% of Republicans and 73% of Independents on top of 96% of those from his own party.
He also won all but 13 counties in the western part of the state, a surprising feat in normally heavily Republican Nebraska.
Nelson was thought to be in danger of losing his seat in 2006, as it was thought his successor as governor, Mike Johanns, was almost certain to run against him; that speculation ended when Johanns was appointed U.S. Secretary of Agriculture. With Johanns's move to Washington, few high-profile Republicans stepped up to run against Nelson, as the state party focused its attention on the governor's race. The Republican nomination was won by Pete Ricketts, a former TD Ameritrade executive.
In the general election, Nelson was endorsed by the National Rifle Association, Nebraska Right to Life (National Right to Life's state affiliate), Nebraskans United for Life, the U.S. Chamber of Commerce, the National Federation of Independent Businesses, Nebraska Farmers Union PAC, National Farmers Union PAC, the Veterans of Foreign Wars PAC, the Business-Industry Political Action Committee, and the Omaha Police Union, all conservative-leaning groups.
Nelson defeated Ricketts 64%-36%, the biggest victory margin for a Democratic Senate candidate in Nebraska since Edward Zorinsky won 66% of the vote in 1982. In doing so, he received the votes of 42% of Republicans and 73% of Independents on top of 96% of those from his own party. He also won all but 13 counties in the western part of the state, a surprising feat in normally heavily Republican Nebraska.
Ben Nelson