Large vertebrates are the cougar (Puma concolor), oncilla (Leopardus tigrinus), spectacled bear (Tremarctos ornatus), Geoffroy's spider monkey (Ateles geoffroyi), brown woolly monkey (Lagothrix lagothricha), South American tapir (Tapirus terrestris), mountain tapir (Tapirus pinchaque), little red brocket (Mazama rufina), pacarana (Dinomys branickii), mountain paca (Cuniculus taczanowskii) and Venezuelan red howler (Alouatta seniculus).

The brown woolly monkey, mountain tapir and spectacled bear are of special concern.

Endangered mammals include black-headed spider monkey (Ateles fusciceps), red-crested tree-rat (Santamartamys rufodorsalis), Handley's slender opossum (Marmosops handleyi), white-footed tamarin (Saguinus leucopus) and mountain tapir (Tapirus pinchaque).

Endangered reptiles include Daniel's large scale lizard (Ptychoglossus danieli) and Colombian lightbulb lizard (Riama columbiana).

Endemic species of birds include the burrowing owl (Athene cunicularia tolimae) and velvet-fronted euphonia (Euphonia concinna), 
Resident birds include Andean cock-of-the-rock (Rupicola peruvianus), black-and-chestnut eagle (Spizaetus isidori), blue-billed curassow (Crax alberti), crested quetzal (Pharomachrus antisianus), golden-headed quetzal (Pharomachrus auriceps), wattled guan (Aburria aburri) and yellow-eared parrot (Ognorhynchus icterotis)
The yellow-eared parrot is of special concern.

Migratory song-birds and raptors include broad-winged hawk (Buteo platypterus), rose-breasted grosbeak (Pheucticus ludovicianus), summer tanager (Piranga rubra) and Swainson's hawk (Buteo swainsoni).

Endangered birds include Antioquia bristle tyrant (Phylloscartes lanyoni), black-and-chestnut eagle (Spizaetus isidori), blue-billed curassow (Crax alberti), Cauca guan (Penelope perspicax), chestnut-bellied hummingbird (Amazilia castaneiventris), Fuertes's parrot (Hapalopsittaca fuertesi), gorgeted wood quail (Odontophorus strophium), Tolima dove (Leptotila conoveri) and yellow-headed brush finch (Atlapetes flaviceps).

Endangered amphibians include Santander poison frog (Andinobates virolinensis), Huila stubfoot toad (Atelopus ebenoides), Forest stubfoot toad (Atelopus farci), San Isidro stubfoot toad (Atelopus pedimarmoratus), Atelopus simulatus, Atelopus sonsonensis, Bogota stubfoot toad (Atelopus subornatus), Orphan salamander (Bolitoglossa capitana), Pandi mushroomtongue salamander)(Bolitoglossa pandi), Antioquia marsupial frog (Gastrotheca bufona), Johnson's horned treefrog (Hemiphractus johnsoni), Hyalinobatrachium esmeralda, Lynch's Colombian tree frog (Hyloscirtus lynchi), Rio Luisito tree frog (Hyloscirtus piceigularis), Ruiz's rocket frog (Hyloxalus ruizi), Boqueron robber frog (Hypodactylus latens), Niceforonia adenobrachia, El Estadero rain frog (Pristimantis actinolaimus), wine robber frog (Pristimantis bacchus), rana camuflada (Pristimantis fetosus), rana pierniamarilla (Pristimantis helvolus), Hernandez's robber frog (Pristimantis hernandezi), Pristimantis jorgevelosai, rana picuda (Pristimantis lemur), rana camuflada (Pristimantis lichenoides), spotted robber frog (Pristimantis maculosus), Pristimantis parectatus, Los Patos robber frog (Pristimantis scoloblepharus), Gambita robber frog (Pristimantis spilogaster), Pristimantis suetus, Rana de los torrentes (Pristimantis torrenticola), Pristimantis tribulosus, rana camuflada (Pristimantis veletis) and Colombian beaked toad (Rhinella nicefori).
Large vertebrates are the cougar (Puma concolor), oncilla (Leopardus tigrinus), spectacled bear (Tremarctos ornatus), Geoffroy's spider monkey (Ateles geoffroyi), brown woolly monkey (Lagothrix lagothricha), South American tapir (Tapirus terrestris), mountain tapir (Tapirus pinchaque), little red brocket (Mazama rufina), pacarana (Dinomys branickii), mountain paca (Cuniculus taczanowskii) and Venezuelan red howler (Alouatta seniculus).
The brown woolly monkey, mountain tapir and spectacled bear are of special concern.
Endangered mammals include black-headed spider monkey (Ateles fusciceps), red-crested tree-rat (Santamartamys rufodorsalis), Handley's slender opossum (Marmosops handleyi), white-footed tamarin (Saguinus leucopus) and mountain tapir (Tapirus pinchaque).
Endangered reptiles include Daniel's large scale lizard (Ptychoglossus danieli) and Colombian lightbulb lizard (Riama columbiana).
Endemic species of birds include the burrowing owl (Athene cunicularia tolimae) and velvet-fronted euphonia (Euphonia concinna), 
Resident birds include Andean cock-of-the-rock (Rupicola peruvianus), black-and-chestnut eagle (Spizaetus isidori), blue-billed curassow (Crax alberti), crested quetzal (Pharomachrus antisianus), golden-headed quetzal (Pharomachrus auriceps), wattled guan (Aburria aburri) and yellow-eared parrot (Ognorhynchus icterotis)
The yellow-eared parrot is of special concern.
Migratory song-birds and raptors include broad-winged hawk (Buteo platypterus), rose-breasted grosbeak (Pheucticus ludovicianus), summer tanager (Piranga rubra) and Swainson's hawk (Buteo swainsoni).
Endangered birds include Antioquia bristle tyrant (Phylloscartes lanyoni), black-and-chestnut eagle (Spizaetus isidori), blue-billed curassow (Crax alberti), Cauca guan (Penelope perspicax), chestnut-bellied hummingbird (Amazilia castaneiventris), Fuertes's parrot (Hapalopsittaca fuertesi), gorgeted wood quail (Odontophorus strophium), Tolima dove (Leptotila conoveri) and yellow-headed brush finch (Atlapetes flaviceps).
Endangered amphibians include Santander poison frog (Andinobates virolinensis), Huila stubfoot toad (Atelopus ebenoides), Forest stubfoot toad (Atelopus farci), San Isidro stubfoot toad (Atelopus pedimarmoratus), Atelopus simulatus, Atelopus sonsonensis, Bogota stubfoot toad (Atelopus subornatus), Orphan salamander (Bolitoglossa capitana), Pandi mushroomtongue salamander)(Bolitoglossa pandi), Antioquia marsupial frog (Gastrotheca bufona), Johnson's horned treefrog (Hemiphractus johnsoni), Hyalinobatrachium esmeralda, Lynch's Colombian tree frog (Hyloscirtus lynchi), Rio Luisito tree frog (Hyloscirtus piceigularis), Ruiz's rocket frog (Hyloxalus ruizi), Boqueron robber frog (Hypodactylus latens), Niceforonia adenobrachia, El Estadero rain frog (Pristimantis actinolaimus), wine robber frog (Pristimantis bacchus), rana camuflada (Pristimantis fetosus), rana pierniamarilla (Pristimantis helvolus), Hernandez's robber frog (Pristimantis hernandezi), Pristimantis jorgevelosai, rana picuda (Pristimantis lemur), rana camuflada (Pristimantis lichenoides), spotted robber frog (Pristimantis maculosus), Pristimantis parectatus, Los Patos robber frog (Pristimantis scoloblepharus), Gambita robber frog (Pristimantis spilogaster), Pristimantis suetus, Rana de los torrentes (Pristimantis torrenticola), Pristimantis tribulosus, rana camuflada (Pristimantis veletis) and Colombian beaked toad (Rhinella nicefori).
Magdalena Valley montane forests