The original Saxon church on the site was dedicated to St Edmund the King and Martyr.
In 1137 it was given to the Priory of St Bartholomew.
During the Crusades in the 12th century the church was renamed St Edmund and the Holy Sepulchre, in reference to the Church of the Holy Sepulchre in Jerusalem, by soldiers who passed by the church on the way to the Holy Lands.
The name eventually became contracted to St Sepulchre.

The church is today the largest parish church in the City.
It was completely rebuilt in the 15th century but was gutted by the Great Fire of London in 1666, which left only the outer walls, the tower and the porch standing.
Modified in the 18th century, the church underwent extensive restoration in 1878.
It narrowly avoided destruction in the Second World War, although the 18th-century watch-house in its churchyard (erected to deter grave-robbers) was destroyed and had to be rebuilt.

The interior of the church is a wide, roomy space with a coffered ceiling installed in 1834.
 The Vicars' old residence has recently been renovated into a modern living quarter.

During the reign of Mary I in 1555, St Sepulchre's vicar, John Rogers, was burned as a heretic.
The original Saxon church on the site was dedicated to St Edmund the King and Martyr. In 1137 it was given to the Priory of St Bartholomew. During the Crusades in the 12th century the church was renamed St Edmund and the Holy Sepulchre, in reference to the Church of the Holy Sepulchre in Jerusalem, by soldiers who passed by the church on the way to the Holy Lands. The name eventually became contracted to St Sepulchre.
The church is today the largest parish church in the City. It was completely rebuilt in the 15th century but was gutted by the Great Fire of London in 1666, which left only the outer walls, the tower and the porch standing. Modified in the 18th century, the church underwent extensive restoration in 1878. It narrowly avoided destruction in the Second World War, although the 18th-century watch-house in its churchyard (erected to deter grave-robbers) was destroyed and had to be rebuilt.
The interior of the church is a wide, roomy space with a coffered ceiling installed in 1834.  The Vicars' old residence has recently been renovated into a modern living quarter.
During the reign of Mary I in 1555, St Sepulchre's vicar, John Rogers, was burned as a heretic.
St Sepulchre-without-Newgate