From the 5th to the 10th century there are no historical mentions of Tusculum.
In the 10th century it was the base of the Counts of Tusculum, an important family in the Medieval History of Rome.
They were a clan system whose first mentioned member is Theophylact I (died 924).
His daughter Marozia married Alberic I, Marquis of Spoleto and Camerino, and was for a while the arbiter of political and religious affairs in Rome—a position which the Counts held for a long period of time.
They were pro-Byzantine and against the German Emperors.
From their clan came several Popes in the period between 914 and 1049.

Gregory I of Tusculum rebuilt the fortress on the Tuscolo hill, and gave as a gift the "Criptaferrata" to Saint Nilus the Younger, where the latter built a famous abbey.
Gregory also headed the rebellion of the Roman people of 1001 against the German Emperor Otto III.

After 1049 the Counts of Tusculum Papacy declined as the particular "formula" of the papacy-family became outdated.
Subsequent events from 1062 confirmed the change of the Counts' politics, which became pro-Emperor in opposition to the Commune of Rome.
Tusculum had in this time several notable guests: Henry III, Holy Roman Emperor, and his wife Empress Agnes in 1046, the Pope Eugene III from 1149, Louis VII of France and his wife Eleanor of Aquitaine in 1149, Frederick Barbarossa and the English Pope Adrian IV in 1155.

In 1167 the Roman communal army attacked Tusculum (Battle of Monte Porzio), but it was defeated by the Emperor-allied army, headed by Christian I, Archbishop of Mainz; in the summer of the same year, however, a plague decimated the imperial army and Frederick Barbarossa was forced to get back to Germany.
From the 5th to the 10th century there are no historical mentions of Tusculum. In the 10th century it was the base of the Counts of Tusculum, an important family in the Medieval History of Rome. They were a clan system whose first mentioned member is Theophylact I (died 924). His daughter Marozia married Alberic I, Marquis of Spoleto and Camerino, and was for a while the arbiter of political and religious affairs in Rome—a position which the Counts held for a long period of time. They were pro-Byzantine and against the German Emperors. From their clan came several Popes in the period between 914 and 1049.
Gregory I of Tusculum rebuilt the fortress on the Tuscolo hill, and gave as a gift the "Criptaferrata" to Saint Nilus the Younger, where the latter built a famous abbey. Gregory also headed the rebellion of the Roman people of 1001 against the German Emperor Otto III.
After 1049 the Counts of Tusculum Papacy declined as the particular "formula" of the papacy-family became outdated. Subsequent events from 1062 confirmed the change of the Counts' politics, which became pro-Emperor in opposition to the Commune of Rome. Tusculum had in this time several notable guests: Henry III, Holy Roman Emperor, and his wife Empress Agnes in 1046, the Pope Eugene III from 1149, Louis VII of France and his wife Eleanor of Aquitaine in 1149, Frederick Barbarossa and the English Pope Adrian IV in 1155.
In 1167 the Roman communal army attacked Tusculum (Battle of Monte Porzio), but it was defeated by the Emperor-allied army, headed by Christian I, Archbishop of Mainz; in the summer of the same year, however, a plague decimated the imperial army and Frederick Barbarossa was forced to get back to Germany.
Tusculum