On 20 April 2010, Ochoa released a statement indicating her intent to retire from professional golf.
 At a press conference held in Mexico City on 23 April 2010, Ochoa said her last tournament would be the 2010 Tres Marias Championship to be played from 29 April through 2 May. She said that her career plan had always been to play for "around ten years" and to be the number 1 ranked player in the world.
She also said: 
I just want to be honest with all of you.
I went to Asia, and after two or three days of being in Thailand, it was really easy to me – it was really clear to see that I didn't want to be out there, you know.
I just was thinking of other things.
I wanted to get home.
I wanted to start working on the foundation.
I wanted to be here close to my family.

Ochoa said she would still maintain her membership in the LPGA and would play in the Lorena Ochoa Invitational and "I'm going to leave the door open in case I want to come back in one or two years to play a U.S. Open or a Kraft Nabisco."

Ochoa made a limited return to competitive golf in 2012, having been invited by her sponsor, Lacoste, to compete in the Lacoste Ladies Open de France, an event on the Ladies European Tour.
Ochoa finished the event in T22, 13 shots behind the winner Stacey Keating.
Ochoa also announced she would compete in the 2012 edition of her own event, the Lorena Ochoa Invitational.
On 20 April 2010, Ochoa released a statement indicating her intent to retire from professional golf.  At a press conference held in Mexico City on 23 April 2010, Ochoa said her last tournament would be the 2010 Tres Marias Championship to be played from 29 April through 2 May. She said that her career plan had always been to play for "around ten years" and to be the number 1 ranked player in the world. She also said: 
I just want to be honest with all of you. I went to Asia, and after two or three days of being in Thailand, it was really easy to me – it was really clear to see that I didn't want to be out there, you know. I just was thinking of other things. I wanted to get home. I wanted to start working on the foundation. I wanted to be here close to my family.
Ochoa said she would still maintain her membership in the LPGA and would play in the Lorena Ochoa Invitational and "I'm going to leave the door open in case I want to come back in one or two years to play a U.S. Open or a Kraft Nabisco."
Ochoa made a limited return to competitive golf in 2012, having been invited by her sponsor, Lacoste, to compete in the Lacoste Ladies Open de France, an event on the Ladies European Tour. Ochoa finished the event in T22, 13 shots behind the winner Stacey Keating. Ochoa also announced she would compete in the 2012 edition of her own event, the Lorena Ochoa Invitational.
Lorena Ochoa