Clinton was married twice.
On February 13, 1796, he married Maria Franklin, daughter of the prominent New York Quaker merchant Walter Franklin and descendant of John Bowne and Elizabeth Fones.
With her, he had ten children, and four sons and three daughters had survived at the time of her death in 1818.
Among his children with Franklin was George William Clinton, who served as mayor of Buffalo, New York from 1842 to 1843.

On May 8, 1819, he married Catharine Jones, the daughter of a New York physician, Thomas Jones and his wife, Margaret (née Livingston) Jones (a daughter of Edward Livingston).
Catharine's sister, Mary (née Jones) Gelston, was the wife of Deacon Maltby Gelston of Southampton, and the mother of David Gelston, Collector of the Port of New York.
Catharine outlived her husband.

In 1813, Clinton became a hereditary member of the New York Society of the Cincinnati in succession to his brother, Lieutenant Alexander Clinton, who was an original member of the society.

When DeWitt Clinton died suddenly in Albany on February 11, 1828, he left his family in poor financial condition.
While Clinton was a fine administrator in government, he had handled his own financial affairs rather poorly.
As a result, the Clinton family was badly in arrears and had no means of support after the governor's death.
One creditor alone put in a claim for $6,000.
Fearing that he might not get his money, the creditor obtained a judgment that resulted in a public sale of most of the Clinton family possessions.
Enough money was realized from the sale of the property to satisfy the judgment, but nothing was left to help the Clinton family through the difficult years ahead.
The governor received the grandest of state funerals, but when it was all over, the family had no place to bury him.
His widow was completely without funds to purchase a suitable grave site.
As a result, Clinton's remains were placed in the family vault of Dr. Samuel Stringer (1735-1817), an old friend and fellow Mason from Albany, in the old Swan Street Cemetery.

Sixteen years later, enough money was collected to provide a suitable burial.
On June 21, 1844, a newspaper in Albany printed this small announcement: "The remains of DeWitt Clinton, which had been deposited in the cemetery in Swan Street, were removed to New York for interment under a monument created by the family."
Clinton was reinterred at the Green-Wood Cemetery in Brooklyn, New York.
Clinton was married twice. On February 13, 1796, he married Maria Franklin, daughter of the prominent New York Quaker merchant Walter Franklin and descendant of John Bowne and Elizabeth Fones. With her, he had ten children, and four sons and three daughters had survived at the time of her death in 1818. Among his children with Franklin was George William Clinton, who served as mayor of Buffalo, New York from 1842 to 1843.
On May 8, 1819, he married Catharine Jones, the daughter of a New York physician, Thomas Jones and his wife, Margaret (née Livingston) Jones (a daughter of Edward Livingston). Catharine's sister, Mary (née Jones) Gelston, was the wife of Deacon Maltby Gelston of Southampton, and the mother of David Gelston, Collector of the Port of New York. Catharine outlived her husband.
In 1813, Clinton became a hereditary member of the New York Society of the Cincinnati in succession to his brother, Lieutenant Alexander Clinton, who was an original member of the society.
When DeWitt Clinton died suddenly in Albany on February 11, 1828, he left his family in poor financial condition. While Clinton was a fine administrator in government, he had handled his own financial affairs rather poorly. As a result, the Clinton family was badly in arrears and had no means of support after the governor's death. One creditor alone put in a claim for $6,000. Fearing that he might not get his money, the creditor obtained a judgment that resulted in a public sale of most of the Clinton family possessions. Enough money was realized from the sale of the property to satisfy the judgment, but nothing was left to help the Clinton family through the difficult years ahead. The governor received the grandest of state funerals, but when it was all over, the family had no place to bury him. His widow was completely without funds to purchase a suitable grave site. As a result, Clinton's remains were placed in the family vault of Dr. Samuel Stringer (1735-1817), an old friend and fellow Mason from Albany, in the old Swan Street Cemetery.
Sixteen years later, enough money was collected to provide a suitable burial. On June 21, 1844, a newspaper in Albany printed this small announcement: "The remains of DeWitt Clinton, which had been deposited in the cemetery in Swan Street, were removed to New York for interment under a monument created by the family." Clinton was reinterred at the Green-Wood Cemetery in Brooklyn, New York.
DeWitt Clinton