To the north of Egypt, trade contacts with Byblos on the Levantine coast, which existed during much of the Fifth Dynasty, were seemingly active during Nyuserre's reign, as suggested by a fragment of cylindrical alabaster vase bearing his name uncovered in the city.

East of Egypt, Nyuserre commissioned at least one expedition to the Wadi Maghareh in Sinai, where mines of copper and turquoise were exploited during much of the Old Kingdom.
This expedition left a large rock relief, now in the Egyptian Museum in Cairo.
The relief shows Nyuserre "smiting the Bedouins of all foreign lands, the great god, lord of the two lands".

At the right of Nyuserre is a dedication to "Thoth, lord of the foreign lands, who has made pure libations".
This expedition departed Egypt from the port of Ain Sukhna, on the western shore of the Gulf of Suez, as revealed by seal impressions bearing Nyuserre's name found on the site.
The port comprised large galleries carved into the sandstone serving as living quarters and storage places.
The wall of one such gallery was inscribed with a text in ink mentioning the expedition to Sinai and dating it to the year of the second cattle count – possibly Nyuserre's fourth year on the throne.

To the south of Egypt, in Lower Nubia, Nyuserre exploited the gneiss quarries of Gebel el-Asr near Aswan, which provided material for buildings and statues, as shown by a fragmentary stone stela inscribed with Nyuserre's Horus name that was discovered in a settlement adjacent to the quarries.
To the north of Egypt, trade contacts with Byblos on the Levantine coast, which existed during much of the Fifth Dynasty, were seemingly active during Nyuserre's reign, as suggested by a fragment of cylindrical alabaster vase bearing his name uncovered in the city.
East of Egypt, Nyuserre commissioned at least one expedition to the Wadi Maghareh in Sinai, where mines of copper and turquoise were exploited during much of the Old Kingdom. This expedition left a large rock relief, now in the Egyptian Museum in Cairo. The relief shows Nyuserre "smiting the Bedouins of all foreign lands, the great god, lord of the two lands".
At the right of Nyuserre is a dedication to "Thoth, lord of the foreign lands, who has made pure libations". This expedition departed Egypt from the port of Ain Sukhna, on the western shore of the Gulf of Suez, as revealed by seal impressions bearing Nyuserre's name found on the site. The port comprised large galleries carved into the sandstone serving as living quarters and storage places. The wall of one such gallery was inscribed with a text in ink mentioning the expedition to Sinai and dating it to the year of the second cattle count – possibly Nyuserre's fourth year on the throne.
To the south of Egypt, in Lower Nubia, Nyuserre exploited the gneiss quarries of Gebel el-Asr near Aswan, which provided material for buildings and statues, as shown by a fragmentary stone stela inscribed with Nyuserre's Horus name that was discovered in a settlement adjacent to the quarries.
Nyuserre Ini