In November 1585, Aloysius gave up all rights of inheritance, which was confirmed by the emperor.
He went to Rome and, because of his noble birth, gained an audience with Pope Sixtus V. Following a brief stay at the Palazzo Aragona Gonzaga, the Roman home of his cousin, Cardinal Scipione Gonzaga, on 25 November 1585 he was accepted into the novitiate of the Society of Jesus in Rome.
During this period, he was asked to moderate his asceticism somewhat and to be more social with the other novices.

Aloysius' health continued to cause problems.
In addition to the kidney disease, he also suffered from a skin disease, chronic headaches and insomnia.
He was sent to Milan for studies, but after some time he was sent back to Rome because of his health.
On 25 November 1587, he took the three religious vows of chastity, poverty and obedience.
In February and March 1588, he received minor orders and started studying theology to prepare for ordination.
In 1589, he was called to Mantua to mediate between his brother Rodolfo and the Duke of Mantua.
He returned to Rome in May 1590.
It is said that, later that year, he had a vision in which the Archangel Gabriel told him that he would die within a year.

In 1591, a plague broke out in Rome.
The Jesuits opened a hospital for the stricken, and Aloysius volunteered to work there.
After begging alms for the victims, Aloysius began working with the sick, carrying the dying from the streets into a hospital founded by the Jesuits.
There he washed and fed the plague victims, preparing them as best he could to receive the sacraments.
But though he threw himself into his tasks, he privately confessed to his spiritual director, Fr.
Robert Bellarmine, that his constitution was revolted by the sights and smells of the work; he had to work hard to overcome his physical repulsion.

At the time, many of the younger Jesuits had become infected with the disease, and so Aloysius's superiors forbade him from returning to the hospital.
But Aloysius—long accustomed to refusals from his father—persisted and requested permission to return, which was granted.
Eventually he was allowed to care for the sick, but only at another hospital, called Our Lady of Consolation, where those with contagious diseases were not admitted.
While there, Aloysius lifted a man out of his sickbed, tended to him, and brought him back to his bed.
But the man was infected with the plague.
Aloysius grew ill and was bedridden by 3 March 1591, a few days before his 23rd birthday.

Aloysius rallied for a time, but as fever and a cough set in, he declined for many weeks.
It seemed certain that he would die in a short time, and he was given Extreme Unction.
While he was ill, he spoke several times with his confessor, the cardinal and later saint, Robert Bellarmine.
Aloysius had another vision and told several people that he would die on the Octave of the feast of Corpus Christi.
On that day, 21 June 1591, he seemed very well in the morning, but insisted that he would die before the day was over.
As he began to grow weak, Bellarmine gave him the last rites and recited the prayers for the dying.
He died just before midnight.
As Fr.
Tylenda tells the story, "When the two Jesuits came to his side, they noticed a change in his face and realized that their young Aloysius was dying.
His eyes were fixed on the crucifix he held in his hands, and as he tried to pronounce the name of Jesus he died."

Purity was his notable virtue.
The Carmelite mystic St. Maria Magdalena de Pazzi claimed to have had a vision of him on 4 April 1600.
She described him as radiant in glory because of his "interior works," a hidden martyr for his great love of God.
In November 1585, Aloysius gave up all rights of inheritance, which was confirmed by the emperor. He went to Rome and, because of his noble birth, gained an audience with Pope Sixtus V. Following a brief stay at the Palazzo Aragona Gonzaga, the Roman home of his cousin, Cardinal Scipione Gonzaga, on 25 November 1585 he was accepted into the novitiate of the Society of Jesus in Rome. During this period, he was asked to moderate his asceticism somewhat and to be more social with the other novices.
Aloysius' health continued to cause problems. In addition to the kidney disease, he also suffered from a skin disease, chronic headaches and insomnia. He was sent to Milan for studies, but after some time he was sent back to Rome because of his health. On 25 November 1587, he took the three religious vows of chastity, poverty and obedience. In February and March 1588, he received minor orders and started studying theology to prepare for ordination. In 1589, he was called to Mantua to mediate between his brother Rodolfo and the Duke of Mantua. He returned to Rome in May 1590. It is said that, later that year, he had a vision in which the Archangel Gabriel told him that he would die within a year.
In 1591, a plague broke out in Rome. The Jesuits opened a hospital for the stricken, and Aloysius volunteered to work there. After begging alms for the victims, Aloysius began working with the sick, carrying the dying from the streets into a hospital founded by the Jesuits. There he washed and fed the plague victims, preparing them as best he could to receive the sacraments. But though he threw himself into his tasks, he privately confessed to his spiritual director, Fr. Robert Bellarmine, that his constitution was revolted by the sights and smells of the work; he had to work hard to overcome his physical repulsion.
At the time, many of the younger Jesuits had become infected with the disease, and so Aloysius's superiors forbade him from returning to the hospital. But Aloysius—long accustomed to refusals from his father—persisted and requested permission to return, which was granted. Eventually he was allowed to care for the sick, but only at another hospital, called Our Lady of Consolation, where those with contagious diseases were not admitted. While there, Aloysius lifted a man out of his sickbed, tended to him, and brought him back to his bed. But the man was infected with the plague. Aloysius grew ill and was bedridden by 3 March 1591, a few days before his 23rd birthday.
Aloysius rallied for a time, but as fever and a cough set in, he declined for many weeks. It seemed certain that he would die in a short time, and he was given Extreme Unction. While he was ill, he spoke several times with his confessor, the cardinal and later saint, Robert Bellarmine. Aloysius had another vision and told several people that he would die on the Octave of the feast of Corpus Christi. On that day, 21 June 1591, he seemed very well in the morning, but insisted that he would die before the day was over. As he began to grow weak, Bellarmine gave him the last rites and recited the prayers for the dying. He died just before midnight. As Fr. Tylenda tells the story, "When the two Jesuits came to his side, they noticed a change in his face and realized that their young Aloysius was dying. His eyes were fixed on the crucifix he held in his hands, and as he tried to pronounce the name of Jesus he died."
Purity was his notable virtue. The Carmelite mystic St. Maria Magdalena de Pazzi claimed to have had a vision of him on 4 April 1600. She described him as radiant in glory because of his "interior works," a hidden martyr for his great love of God.
Aloysius Gonzaga