In February 2016, Ramos won the Luis Aragonés Award by Marca which distinguished him as the best player of the national team in the past year.
With David de Gea selected ahead of Iker Casillas in Spain's starting line-up, Ramos captained the team at UEFA Euro 2016.
On 21 June 2016, he had a penalty kick saved by Danijel Subašić in a 2–1 loss to Croatia.
Spain finished their Euro group as runners-up and crashed out in the Round of 16 against Italy.

On 23 March 2018, days before turning 32, Ramos earned his 150th cap for Spain in a 1–1 friendly draw with Germany in Düsseldorf.
Only Iker Casillas had previously reached the mark for the team.

Ramos was included in the Spain squad for the 2018 FIFA World Cup and would go into his fourth tournament, and first World Cup as Captain after Iker Casillas missed out.
He played in all three of Spain's Group stage matches as they topped the 'Group of Death' ahead of European Champions Portugal.
In the Round of 16 against Russia, Ramos believed he scored the opening goal but it was later credited as an Sergei Ignashevich own goal.
The match ended 1–1 after Extra Time and was decided on penalties (4–2) as the hosts eliminated La Roja.
Ramos scored Spain's fourth penalty but it wasn't enough as teammates Koke and Aspas both had their penalties saved.
In February 2016, Ramos won the Luis Aragonés Award by Marca which distinguished him as the best player of the national team in the past year. With David de Gea selected ahead of Iker Casillas in Spain's starting line-up, Ramos captained the team at UEFA Euro 2016. On 21 June 2016, he had a penalty kick saved by Danijel Subašić in a 2–1 loss to Croatia. Spain finished their Euro group as runners-up and crashed out in the Round of 16 against Italy.
On 23 March 2018, days before turning 32, Ramos earned his 150th cap for Spain in a 1–1 friendly draw with Germany in Düsseldorf. Only Iker Casillas had previously reached the mark for the team.
Ramos was included in the Spain squad for the 2018 FIFA World Cup and would go into his fourth tournament, and first World Cup as Captain after Iker Casillas missed out. He played in all three of Spain's Group stage matches as they topped the 'Group of Death' ahead of European Champions Portugal. In the Round of 16 against Russia, Ramos believed he scored the opening goal but it was later credited as an Sergei Ignashevich own goal. The match ended 1–1 after Extra Time and was decided on penalties (4–2) as the hosts eliminated La Roja. Ramos scored Spain's fourth penalty but it wasn't enough as teammates Koke and Aspas both had their penalties saved.
Sergio Ramos