Hurst joined the University of Nottingham as a postdoctoral researcher in 1985, obtained a Science and Engineering Research Council (SERC) Postdoctoral Research Fellowship from 1986 to 1988, a SERC Advanced Fellowship from 1989 to 1984 and an Agricultural and Food Research Council (AFRC)/BBSRC Advanced Fellowship from 1994 to 1998.
 Hurst works on the mechanisms and evolution of scent communication in animals.
She is interested in the roles of volatile and non-volatile scents.
She was appointed the William Prescott Professor of Animal Science at the University of Liverpool in 1998 and Head of Mammalian Behaviour & Evolution Group.

Her main research interests are in the chemobiology of competitive signalling in mammals.
Hurst became interested in the signals that determine animal mate choice.
She is interested in how scents are used in sexual communications.
She demonstrated that the quality of an animal's odour determines the chances that it will be selected as a mate.
She found that female mice prefer to nest with their sisters, irrespective of whether they knew each other before.
Specifically, female house mice prefer partners that share their own major urinary protein genotype.
In the absence of this phenotype match, females preferred partners with whom they share multiple-loci across the genome.

Hurst identified a non-volatile pheromone that was released in male urine that female mice find highly attractive.
She went on to find that this pheromone was a major urinary proteins (MUP20), which she called darcin named after Mr. Darcy in Jane Austen's novel Pride and Prejudice.
Hurst went on to establish that this pheromone could stimulate both short and long-term learning and that darcin and other major urinary proteins influence the odour signature that female mice learn.
She also showed that darcin increased neurogenesis in the olfactory bulb and hippocampus.
and has been involved with work that has identified a genetically determined circuit-extending from the accessory olfactory bulb to the posterior medial amygdala mediating all behavioural responses to darcin.
She found that female mice are more attracted to male mice with their own territory.
She found that darcin and other major urinary proteins influence the odour signature that female mice learn.
She edited volume 11 of Chemical Signals in Vertebrates that followed a conference of the same name in Chester, UK.

Her research is directed in part to the development of humane control of rodent pests.
She also identified non-aversive handling methods that would reduce anxiety in mice, allowing them to be more reliable in laboratory tests.
Hurst developed the use of mouse-friendly handling tunnels, reducing their anxiety and allowing them to explore more during animal testing.
Hurst is also interested in how animals can detect scent-cues of ill-health and disease. ]
For this work, she was awarded the NC3Rs prize in 2010.
Hurst is also interested in how animals can detect scent-cues of ill-health and disease.

In 2010 Hurst was appointed President for the Association for the Study of Animal Behaviour (ASAB).
She has supported the Biotechnology and Biological Sciences Research Council (BBSRC) from 2000 – 2019 by serving on grant funding and strategy advisory panels, Appointments Board, and chaired the BBSRC Animal Welfare Programme steering committee.
She has supported the National Centre for the Replacement, Refinement and Reduction of Animals in Research since its inception, including a founding member of the NC3Rs Board and grant funding panel (2004-2010).
She has served on the Council for the Universities Federation for Animal Welfare (UFAW, 1996-2002), on the Royal Society Use of Animals in Research committee (2004-2009) and the Ethical committee for ASAB (1991-1999, chair from 1995).
Hurst has been involved with several studies to improve connections between researchers in the animal welfare community.
Hurst discussed her pheromone research on  In Our Time in 2019.
Hurst joined the University of Nottingham as a postdoctoral researcher in 1985, obtained a Science and Engineering Research Council (SERC) Postdoctoral Research Fellowship from 1986 to 1988, a SERC Advanced Fellowship from 1989 to 1984 and an Agricultural and Food Research Council (AFRC)/BBSRC Advanced Fellowship from 1994 to 1998.  Hurst works on the mechanisms and evolution of scent communication in animals. She is interested in the roles of volatile and non-volatile scents. She was appointed the William Prescott Professor of Animal Science at the University of Liverpool in 1998 and Head of Mammalian Behaviour & Evolution Group. 
Her main research interests are in the chemobiology of competitive signalling in mammals. Hurst became interested in the signals that determine animal mate choice. She is interested in how scents are used in sexual communications. She demonstrated that the quality of an animal's odour determines the chances that it will be selected as a mate. She found that female mice prefer to nest with their sisters, irrespective of whether they knew each other before. Specifically, female house mice prefer partners that share their own major urinary protein genotype. In the absence of this phenotype match, females preferred partners with whom they share multiple-loci across the genome.
Hurst identified a non-volatile pheromone that was released in male urine that female mice find highly attractive. She went on to find that this pheromone was a major urinary proteins (MUP20), which she called darcin named after Mr. Darcy in Jane Austen's novel Pride and Prejudice. Hurst went on to establish that this pheromone could stimulate both short and long-term learning and that darcin and other major urinary proteins influence the odour signature that female mice learn. She also showed that darcin increased neurogenesis in the olfactory bulb and hippocampus. and has been involved with work that has identified a genetically determined circuit-extending from the accessory olfactory bulb to the posterior medial amygdala mediating all behavioural responses to darcin. She found that female mice are more attracted to male mice with their own territory. She found that darcin and other major urinary proteins influence the odour signature that female mice learn. She edited volume 11 of Chemical Signals in Vertebrates that followed a conference of the same name in Chester, UK.
Her research is directed in part to the development of humane control of rodent pests. She also identified non-aversive handling methods that would reduce anxiety in mice, allowing them to be more reliable in laboratory tests. Hurst developed the use of mouse-friendly handling tunnels, reducing their anxiety and allowing them to explore more during animal testing. Hurst is also interested in how animals can detect scent-cues of ill-health and disease. ] For this work, she was awarded the NC3Rs prize in 2010. Hurst is also interested in how animals can detect scent-cues of ill-health and disease.
In 2010 Hurst was appointed President for the Association for the Study of Animal Behaviour (ASAB). She has supported the Biotechnology and Biological Sciences Research Council (BBSRC) from 2000 – 2019 by serving on grant funding and strategy advisory panels, Appointments Board, and chaired the BBSRC Animal Welfare Programme steering committee. She has supported the National Centre for the Replacement, Refinement and Reduction of Animals in Research since its inception, including a founding member of the NC3Rs Board and grant funding panel (2004-2010). She has served on the Council for the Universities Federation for Animal Welfare (UFAW, 1996-2002), on the Royal Society Use of Animals in Research committee (2004-2009) and the Ethical committee for ASAB (1991-1999, chair from 1995). Hurst has been involved with several studies to improve connections between researchers in the animal welfare community. Hurst discussed her pheromone research on  In Our Time in 2019.
Jane Hurst