DeWilde made his much-acclaimed Broadway debut at the age of seven in The Member of the Wedding.
He was the first child actor to win the Donaldson Award, and his talent was praised by John Gielgud the following year.
He also starred in the 1952 film version of the play, which was directed by Fred Zinnemann.

In 1952 deWilde acted in the film Shane as Joey Starrett and was nominated for an Academy Award for Best Supporting Actor for his performance, becoming the youngest nominee for the time in a competitive category.
He had the lead role in his own television series, Jamie which aired in 1953 and 1954.
Although the series was popular, it was canceled due to a contract dispute.
In 1956 he was featured with Walter Brennan, Phil Harris, and Sidney Poitier in the coming-of-age Batjac movie production of Good-bye, My Lady, adapted from James Street's book.
This film showcased the then-rare dog breed Basenji, the African barkless dog, to American audiences.

DeWilde's soft-spoken manner of speech in his early roles was more akin to a Southern drawl.
In 1956 (at age 14) deWilde narrated classical music works Peter and the Wolf by Sergei Prokofiev and The Young Person's Guide to the Orchestra by Benjamin Britten.
He also recorded a reading of Huckleberry Finn on the album The Stories of Mark Twain, along with his Good-bye, My Lady co-star, Walter Brennan.

DeWilde shared an onscreen camaraderie with both James Stewart and Audie Murphy in the 1957 western Night Passage.
In 1958 deWilde continued his career, starring in The Missouri Traveler sharing lead billing with Lee Marvin in another coming-of-age film, this one set in the early 1900s.
He made a mark on screen at age 17 as an adolescent father in the 1959 drama Blue Denim, co-starring Carol Lynley, with the then-mature theme of abortion, even though the word is never used in the film.
He guest-starred on many TV series, including Alcoa Theatre and the popular Western, Wagon Train.
In the 1959 Wagon Train episode, "The Danny Benedict Story", deWilde starred in the title role as the estranged, musically-inclined son of a stern Army colonel.

In 1961 deWilde appeared in the Alfred Hitchcock Presents episode "The Sorcerer's Apprentice".
He portrayed Hugo, a mentally impaired youth who could not separate fact from fantasy.
After seeing a magician saw a woman in half at a carnival, Hugo emulates the trick and kills a woman by sawing her in half.
The episode never aired on NBC because the finale was deemed "too gruesome" by 1960s television standards.
The episode was included in Alfred Hitchcock Presents syndication and was released in public-domain VHS, DVD and video on demand releases.

The following year, deWilde appeared in All Fall Down, opposite Warren Beatty and Eva Marie Saint, and in Martin Ritt's Hud (1963) co-starring with Paul Newman, Patricia Neal and Melvyn Douglas.
Although the only lead actor not to be Oscar-nominated for Hud, deWilde accepted the Best Supporting Actor trophy on behalf of co-star Melvyn Douglas (who was in Spain at the time).
That same year, he appeared on Jack Palance's ABC circus drama, The Greatest Show on Earth.

DeWilde signed a two-picture deal with Disney in 1964.
He first starred in The Tenderfoot, a three-part comedy Western for Walt Disney's Wonderful World of Color TV show with Brian Keith.
The following year he and Keith did Those Calloways for theatrical release, reuniting deWilde with his Good-bye, My Lady star Walter Brennan.
Also in 1965, deWilde played a young PT boat officer, Esn.
Jere Torry, the estranged son serving under his US Navy Admiral father played by  John Wayne in the Pacific theater WWII drama, In Harm's Way (1965).

After 1965, many of his roles were limited to television guest appearances. "
Being small for his age and a bit too pretty ... in his favour as a child ... worked against him as an adult", wrote author Linda Ashcroft after talking with deWilde at a party. "
He spoke of giving up movies until he could come back as a forty-year-old character actor".
DeWilde's final western role was in Dino De Laurentiis' 1971 spaghetti
DeWilde made his much-acclaimed Broadway debut at the age of seven in The Member of the Wedding. He was the first child actor to win the Donaldson Award, and his talent was praised by John Gielgud the following year. He also starred in the 1952 film version of the play, which was directed by Fred Zinnemann.
In 1952 deWilde acted in the film Shane as Joey Starrett and was nominated for an Academy Award for Best Supporting Actor for his performance, becoming the youngest nominee for the time in a competitive category. He had the lead role in his own television series, Jamie which aired in 1953 and 1954. Although the series was popular, it was canceled due to a contract dispute. In 1956 he was featured with Walter Brennan, Phil Harris, and Sidney Poitier in the coming-of-age Batjac movie production of Good-bye, My Lady, adapted from James Street's book. This film showcased the then-rare dog breed Basenji, the African barkless dog, to American audiences.
DeWilde's soft-spoken manner of speech in his early roles was more akin to a Southern drawl. In 1956 (at age 14) deWilde narrated classical music works Peter and the Wolf by Sergei Prokofiev and The Young Person's Guide to the Orchestra by Benjamin Britten. He also recorded a reading of Huckleberry Finn on the album The Stories of Mark Twain, along with his Good-bye, My Lady co-star, Walter Brennan.
DeWilde shared an onscreen camaraderie with both James Stewart and Audie Murphy in the 1957 western Night Passage. In 1958 deWilde continued his career, starring in The Missouri Traveler sharing lead billing with Lee Marvin in another coming-of-age film, this one set in the early 1900s. He made a mark on screen at age 17 as an adolescent father in the 1959 drama Blue Denim, co-starring Carol Lynley, with the then-mature theme of abortion, even though the word is never used in the film. He guest-starred on many TV series, including Alcoa Theatre and the popular Western, Wagon Train. In the 1959 Wagon Train episode, "The Danny Benedict Story", deWilde starred in the title role as the estranged, musically-inclined son of a stern Army colonel.
In 1961 deWilde appeared in the Alfred Hitchcock Presents episode "The Sorcerer's Apprentice". He portrayed Hugo, a mentally impaired youth who could not separate fact from fantasy. After seeing a magician saw a woman in half at a carnival, Hugo emulates the trick and kills a woman by sawing her in half. The episode never aired on NBC because the finale was deemed "too gruesome" by 1960s television standards. The episode was included in Alfred Hitchcock Presents syndication and was released in public-domain VHS, DVD and video on demand releases.
The following year, deWilde appeared in All Fall Down, opposite Warren Beatty and Eva Marie Saint, and in Martin Ritt's Hud (1963) co-starring with Paul Newman, Patricia Neal and Melvyn Douglas. Although the only lead actor not to be Oscar-nominated for Hud, deWilde accepted the Best Supporting Actor trophy on behalf of co-star Melvyn Douglas (who was in Spain at the time). That same year, he appeared on Jack Palance's ABC circus drama, The Greatest Show on Earth.
DeWilde signed a two-picture deal with Disney in 1964. He first starred in The Tenderfoot, a three-part comedy Western for Walt Disney's Wonderful World of Color TV show with Brian Keith. The following year he and Keith did Those Calloways for theatrical release, reuniting deWilde with his Good-bye, My Lady star Walter Brennan. Also in 1965, deWilde played a young PT boat officer, Esn. Jere Torry, the estranged son serving under his US Navy Admiral father played by  John Wayne in the Pacific theater WWII drama, In Harm's Way (1965).
After 1965, many of his roles were limited to television guest appearances. "Being small for his age and a bit too pretty ... in his favour as a child ... worked against him as an adult", wrote author Linda Ashcroft after talking with deWilde at a party. "He spoke of giving up movies until he could come back as a forty-year-old character actor". DeWilde's final western role was in Dino De Laurentiis' 1971 spaghetti
Brandon deWilde