In terms of genetics one finds that autoimmune polyendocrine syndrome type 2 has an autosomal dominant pattern of inheritance, with an incomplete penetrance.
Furthermore, the human leukocyte antigen  involved in this condition are HLA-DQ2(DR3 (DQB*0201)) and HLA-DQ8(DR4 (DQB1*0302)), genetically speaking, which indicates this is a multifactorial disorder, as well.

Should any affected organs show chronic inflammatory infiltrate (lymphocytes), this would be an indication.
Moreover,
autoantibodies reacting to specific antigens is common, in the immune system of an affected individual.
In terms of genetics one finds that autoimmune polyendocrine syndrome type 2 has an autosomal dominant pattern of inheritance, with an incomplete penetrance. Furthermore, the human leukocyte antigen  involved in this condition are HLA-DQ2(DR3 (DQB*0201)) and HLA-DQ8(DR4 (DQB1*0302)), genetically speaking, which indicates this is a multifactorial disorder, as well.
Should any affected organs show chronic inflammatory infiltrate (lymphocytes), this would be an indication. Moreover,
autoantibodies reacting to specific antigens is common, in the immune system of an affected individual.
Autoimmune polyendocrine syndrome type 2