The most ancient and the most prominent asclepeion (or healing temple) according to the geographer of the 1st century BC, Strabo, was situated in Trikala.
The 1st century AD Pool of Bethesda, described in the Gospel of John, chapter 5, was found by archaeologists in 1964 to be part of an asclepeion.
One of the most famous temples of Asclepius was at Epidaurus in north-eastern Peloponnese, dated to the fourth century BC.
Another famous asclepeion was built approximately a century later on the island of Kos, where Hippocrates, the legendary "father of medicine", may have begun his career.
 Other asclepieia were situated in Gortys (in Arcadia), and Pergamum in Asia.

From the fifth century BC onwards, the cult of Asclepius grew very popular and pilgrims flocked to his healing temples (Asclepieia) to be cured of their ills.
Ritual purification would be followed by offerings or sacrifices to the god (according to means), and the supplicant would then spend the night in the holiest part of the sanctuary – the abaton (or adyton).
Any dreams or visions would be reported to a priest who would prescribe the appropriate therapy by a process of interpretation.
Some healing temples also used sacred dogs to lick the wounds of sick petitioners.
In honor of Asclepius, a particular type of non-venomous snake was often used in healing rituals, and these snakes — the Aesculapian Snakes — slithered around freely on the floor in dormitories where the sick and injured slept.
These snakes were introduced at the founding of each new temple of Asclepius throughout the classical world.

The original Hippocratic Oath began with the invocation "I swear by Apollo the Physician and by Asclepius and by Hygieia and Panacea and by all the gods ...".

Some later religious movements claimed links to Asclepius.
In the 2nd century AD the controversial miracle-worker Alexander claimed that his god Glycon, a snake with a "head of linen" was an incarnation of Asclepius.
The Greek language rhetorician and satirist Lucian produced the work Alexander the False Prophet to denounce the swindler for future generations.
He described Alexander as having a character "made up of lying, trickery, perjury, and malice; [it was] facile, audacious, venturesome, diligent in the execution of its schemes, plausible, convincing, masking as good, and wearing an appearance absolutely opposite to its purpose."
In Rome, the College of Aesculapius and Hygia was an association (collegium) that served as a burial society and dining club that also participated in the Imperial cult.

The botanical genus Asclepias (commonly known as milkweed) is named after him and includes the medicinal plant A. tuberosa or "Pleurisy root".

Asclepius was depicted on the reverse of the Greek 10,000 drachmas banknote of 1995–2001.
The most ancient and the most prominent asclepeion (or healing temple) according to the geographer of the 1st century BC, Strabo, was situated in Trikala. The 1st century AD Pool of Bethesda, described in the Gospel of John, chapter 5, was found by archaeologists in 1964 to be part of an asclepeion. One of the most famous temples of Asclepius was at Epidaurus in north-eastern Peloponnese, dated to the fourth century BC. Another famous asclepeion was built approximately a century later on the island of Kos, where Hippocrates, the legendary "father of medicine", may have begun his career.  Other asclepieia were situated in Gortys (in Arcadia), and Pergamum in Asia.
From the fifth century BC onwards, the cult of Asclepius grew very popular and pilgrims flocked to his healing temples (Asclepieia) to be cured of their ills. Ritual purification would be followed by offerings or sacrifices to the god (according to means), and the supplicant would then spend the night in the holiest part of the sanctuary – the abaton (or adyton). Any dreams or visions would be reported to a priest who would prescribe the appropriate therapy by a process of interpretation. Some healing temples also used sacred dogs to lick the wounds of sick petitioners. In honor of Asclepius, a particular type of non-venomous snake was often used in healing rituals, and these snakes — the Aesculapian Snakes — slithered around freely on the floor in dormitories where the sick and injured slept. These snakes were introduced at the founding of each new temple of Asclepius throughout the classical world.
The original Hippocratic Oath began with the invocation "I swear by Apollo the Physician and by Asclepius and by Hygieia and Panacea and by all the gods ...".
Some later religious movements claimed links to Asclepius. In the 2nd century AD the controversial miracle-worker Alexander claimed that his god Glycon, a snake with a "head of linen" was an incarnation of Asclepius. The Greek language rhetorician and satirist Lucian produced the work Alexander the False Prophet to denounce the swindler for future generations. He described Alexander as having a character "made up of lying, trickery, perjury, and malice; [it was] facile, audacious, venturesome, diligent in the execution of its schemes, plausible, convincing, masking as good, and wearing an appearance absolutely opposite to its purpose." In Rome, the College of Aesculapius and Hygia was an association (collegium) that served as a burial society and dining club that also participated in the Imperial cult.
The botanical genus Asclepias (commonly known as milkweed) is named after him and includes the medicinal plant A. tuberosa or "Pleurisy root".
Asclepius was depicted on the reverse of the Greek 10,000 drachmas banknote of 1995–2001.
Asclepius