From the north, the Skyway originally begins in Makati, just south of Gil Puyat Avenue (Buendia Avenue).
It rises above the Magallanes Interchange and returns to its original level after crossing EDSA.
Past its interchange with the NAIA Expressway, it descends into ground level because of height restrictions on structures near Ninoy Aquino International Airport, paralleling SLEX and the PNR Metro South Commuter Line along the Pasay–Taguig boundary.
The Skyway elevates again past the C-5 Exit and Arca South.
From Bicutan, at the start of the Stage 2 segment, it continuously runs above SLEX.
At the Sucat Exit, the Skyway rises above the eastern end of Dr. Santos Avenue and descends before approaching the Alabang toll plaza in Cupang, Muntinlupa.
An exit leads down to the South Luzon Expressway and an entrance ramp carries traffic vice versa.
Past the toll plaza and the exit to SLEX, the Skyway narrows into one lane per direction, and curves westward before joining Alabang–Zapote Road near South Station in Alabang.

Stage 3, presently under construction, is divided into five sections.
Section 1 begins at the Buendia Exit and runs northwards along Osmeña Highway, veers right to Quirino Avenue (C-2) and ends at Tomas Claudio Street.
Section 2 then veers right again through the private San Miguel Yamamura Packaging Corporation plant (owned by the same Skyway concessionaire San Miguel Corporation) in Pandacan, Manila, follows the curve of the San Juan River and connects to Gregorio Araneta Avenue near Santa Mesa, Manila.
Past the Aurora Boulevard intersection, Section 3 moves further northwards along Araneta until it reaches Quezon Avenue, where Section 4 continues, veers left to Sgt.
Rivera Avenue, turns right at A. Bonifacio Avenue towards the Balintawak Interchange at EDSA.
Section 5 starts from there, crosses over EDSA and Quirino Highway, and finally connects to NLEX, ending near the Balintawak Toll Plaza.
Stage 3 will have a total length of 18.68 kilometers (11.61 mi).
From the north, the Skyway originally begins in Makati, just south of Gil Puyat Avenue (Buendia Avenue). It rises above the Magallanes Interchange and returns to its original level after crossing EDSA. Past its interchange with the NAIA Expressway, it descends into ground level because of height restrictions on structures near Ninoy Aquino International Airport, paralleling SLEX and the PNR Metro South Commuter Line along the Pasay–Taguig boundary. The Skyway elevates again past the C-5 Exit and Arca South. From Bicutan, at the start of the Stage 2 segment, it continuously runs above SLEX. At the Sucat Exit, the Skyway rises above the eastern end of Dr. Santos Avenue and descends before approaching the Alabang toll plaza in Cupang, Muntinlupa. An exit leads down to the South Luzon Expressway and an entrance ramp carries traffic vice versa. Past the toll plaza and the exit to SLEX, the Skyway narrows into one lane per direction, and curves westward before joining Alabang–Zapote Road near South Station in Alabang.
Stage 3, presently under construction, is divided into five sections. Section 1 begins at the Buendia Exit and runs northwards along Osmeña Highway, veers right to Quirino Avenue (C-2) and ends at Tomas Claudio Street. Section 2 then veers right again through the private San Miguel Yamamura Packaging Corporation plant (owned by the same Skyway concessionaire San Miguel Corporation) in Pandacan, Manila, follows the curve of the San Juan River and connects to Gregorio Araneta Avenue near Santa Mesa, Manila. Past the Aurora Boulevard intersection, Section 3 moves further northwards along Araneta until it reaches Quezon Avenue, where Section 4 continues, veers left to Sgt. Rivera Avenue, turns right at A. Bonifacio Avenue towards the Balintawak Interchange at EDSA. Section 5 starts from there, crosses over EDSA and Quirino Highway, and finally connects to NLEX, ending near the Balintawak Toll Plaza. Stage 3 will have a total length of 18.68 kilometers (11.61 mi).
Skyway (Metro Manila)