The Edwardian-style station building was designed by the British architects Eustace L. Conder, Roger Conder and Sydney G. Follet together with the engineer Reginald Reynolds.
Building began in June 1909 and the station was opened on 1 August 1915 while being operated by the Central Argentine Railway.
The steel structure for the building was made in Liverpool, England, and re-assembled in Argentina.
For many years it was considered to be the most important example of structural engineering in South America and architecturally one of the finest buildings in the world.

After the railway Nationalisation in Argentina, the station became part of the Bartolomé Mitre Railway, a division of state-owned Ferrocarriles Argentinos, which operated commuter rail and long-distance services to Tucumán (being the Estrella del Norte the most notable of them) When the entire rail network was privatised in the early 1990s, Retiro Mitre was taken over by Trenes de Buenos Aires (TBA) for commuter services and Tucumán Ferrocarriles for long-distance journeys to the province, also crossing Rosario and Santiago del Estero.
Other private companies operating the station were Corredores Ferroviarios and Ferrocentral.

In 1997 the Retiro Mitre station was declared a National Monument.

In 2015 plans were announced to expand the station with new platforms to accommodate long-distance services operated by Operadora Ferroviaria Sociedad del Estado.
The new part of the station would have new road access from Libertador Avenue, replacing land currently used for storage of rolling stock.
The existing buildings are also currently being renovated, including restoration of the train shed.
The Edwardian-style station building was designed by the British architects Eustace L. Conder, Roger Conder and Sydney G. Follet together with the engineer Reginald Reynolds. Building began in June 1909 and the station was opened on 1 August 1915 while being operated by the Central Argentine Railway. The steel structure for the building was made in Liverpool, England, and re-assembled in Argentina. For many years it was considered to be the most important example of structural engineering in South America and architecturally one of the finest buildings in the world.
After the railway Nationalisation in Argentina, the station became part of the Bartolomé Mitre Railway, a division of state-owned Ferrocarriles Argentinos, which operated commuter rail and long-distance services to Tucumán (being the Estrella del Norte the most notable of them) When the entire rail network was privatised in the early 1990s, Retiro Mitre was taken over by Trenes de Buenos Aires (TBA) for commuter services and Tucumán Ferrocarriles for long-distance journeys to the province, also crossing Rosario and Santiago del Estero. Other private companies operating the station were Corredores Ferroviarios and Ferrocentral.
In 1997 the Retiro Mitre station was declared a National Monument.
In 2015 plans were announced to expand the station with new platforms to accommodate long-distance services operated by Operadora Ferroviaria Sociedad del Estado. The new part of the station would have new road access from Libertador Avenue, replacing land currently used for storage of rolling stock. The existing buildings are also currently being renovated, including restoration of the train shed.
Retiro Mitre railway station