The watershed of Panther Run has an area of 3.79 square miles (9.8 km²).
The stream is entirely within the United States Geological Survey quadrangle of Hartleton.
The watershed makes up approximately 2 percent of the Buffalo Creek drainage basin.

About 100 percent of the watershed of Panther Run is on forested land.
The watershed of Panther Run has an area of 3.79 square miles (9.8 km²). The stream is entirely within the United States Geological Survey quadrangle of Hartleton. The watershed makes up approximately 2 percent of the Buffalo Creek drainage basin.
About 100 percent of the watershed of Panther Run is on forested land.
Panther Run