Binghamton is divided into seven neighborhoods.
Downtown Binghamton, also known as Center City, is home to most of the city's largest buildings, and is home to government services.
Located at the northeast corner of the river confluence, downtown is increasingly being populated by college students, and supports a flourishing arts scene.
The North Side is across the Norfolk Southern rail tracks from downtown, lying along the Chenango River.
The North Side is a light commercial and working-class residential section of the city, with Chenango Street serving as its major artery.
The East Side lies east of the Brandywine Highway, along the north bank of the Susquehanna River.
The neighborhood is largely residential with commercial corridors along both Robinson and Court streets, and contains pockets of industrial development along its borders.

Across the Chenango River lies the West Side, a primarily residential neighborhood along the banks of the Susquehanna, containing a combination of family homes, student housing, and stately mansions.
Main Street forms the West Side's commercial corridor, made up of several large supermarkets, pharmacies, bank branches, pubs, restaurants, auto shops, and a few strip malls.
The First Ward is a largely residential neighborhood opposite the railroad tracks from the West Side, but is best known for Antique Row, a series of antique shops that line Clinton Street.
Several gold-domed Christian churches are located in this part of the city, as a result of settlement in the area by many Eastern European immigrants.
 The area is home to several large supermarkets, churches, pharmacies, bank branches, a few bars and restaurants as well as some mom and pop shops that provide such goods as video games and music.
 Ely Park is Binghamton's northernmost neighborhood, and contains its municipal golf course.
It lies on portions of Prospect Mountain and other hills north of the First Ward.

The Southside lies along the south bank of the Susquehanna River, connected to downtown by several bridges.
At the base of the historic South Washington Street Bridge is the Southbridge commercial district.
The neighborhood is partitioned into two separate neighborhood assemblies, divided by Pennsylvania Avenue and Southbridge, due to their distinct characters.
Southside East contains working-class residences and some public housing projects, while Southside West is primarily made up of larger middle-class residences.
Binghamton is divided into seven neighborhoods. Downtown Binghamton, also known as Center City, is home to most of the city's largest buildings, and is home to government services. Located at the northeast corner of the river confluence, downtown is increasingly being populated by college students, and supports a flourishing arts scene. The North Side is across the Norfolk Southern rail tracks from downtown, lying along the Chenango River. The North Side is a light commercial and working-class residential section of the city, with Chenango Street serving as its major artery. The East Side lies east of the Brandywine Highway, along the north bank of the Susquehanna River. The neighborhood is largely residential with commercial corridors along both Robinson and Court streets, and contains pockets of industrial development along its borders.
Across the Chenango River lies the West Side, a primarily residential neighborhood along the banks of the Susquehanna, containing a combination of family homes, student housing, and stately mansions. Main Street forms the West Side's commercial corridor, made up of several large supermarkets, pharmacies, bank branches, pubs, restaurants, auto shops, and a few strip malls. The First Ward is a largely residential neighborhood opposite the railroad tracks from the West Side, but is best known for Antique Row, a series of antique shops that line Clinton Street. Several gold-domed Christian churches are located in this part of the city, as a result of settlement in the area by many Eastern European immigrants.  The area is home to several large supermarkets, churches, pharmacies, bank branches, a few bars and restaurants as well as some mom and pop shops that provide such goods as video games and music.  Ely Park is Binghamton's northernmost neighborhood, and contains its municipal golf course. It lies on portions of Prospect Mountain and other hills north of the First Ward.
The Southside lies along the south bank of the Susquehanna River, connected to downtown by several bridges. At the base of the historic South Washington Street Bridge is the Southbridge commercial district. The neighborhood is partitioned into two separate neighborhood assemblies, divided by Pennsylvania Avenue and Southbridge, due to their distinct characters. Southside East contains working-class residences and some public housing projects, while Southside West is primarily made up of larger middle-class residences.
Binghamton, New York