Little Catawissa Creek begins in a narrow valley in Conyngham Township.
It flows east for a few miles in the valley, flowing roughly parallel to Aristes Ringtown Road.
The creek eventually exits Conyngham Township and Columbia County.

Upon exiting Columbia County, Little Catawissa Creek enters Union Township, Schuylkill County.
It continues east and its valley becomes narrower and shallower.
Over the next several miles, the creek turns east-northeast and its valley gets broader again.
It then turns abruptly north and passes through a ridge.
The creek briefly turns northeast before turning north-northeast after a few hundred feet.
Approximately a mile downstream, it receives its first named tributary, Trexler Run.
At this point, the creek turns abruptly east-northeast.
After some distance, it begins meandering northeast for a few miles, receiving the tributary Stony Run.
It then begins meandering east for a few miles, briefly entering North Union Township, Schuylkill County before reentering East Union Township.
Shortly afterwards, the creek turns north-northeast, crosses into North Union Township again.
A few tenths of a mile downstream, it reaches its confluence with Catawissa Creek.

Little Catawissa Creek joins Catawissa Creek 24.24 miles (39.01 km) upstream of its mouth.
Little Catawissa Creek begins in a narrow valley in Conyngham Township. It flows east for a few miles in the valley, flowing roughly parallel to Aristes Ringtown Road. The creek eventually exits Conyngham Township and Columbia County.
Upon exiting Columbia County, Little Catawissa Creek enters Union Township, Schuylkill County. It continues east and its valley becomes narrower and shallower. Over the next several miles, the creek turns east-northeast and its valley gets broader again. It then turns abruptly north and passes through a ridge. The creek briefly turns northeast before turning north-northeast after a few hundred feet. Approximately a mile downstream, it receives its first named tributary, Trexler Run. At this point, the creek turns abruptly east-northeast. After some distance, it begins meandering northeast for a few miles, receiving the tributary Stony Run. It then begins meandering east for a few miles, briefly entering North Union Township, Schuylkill County before reentering East Union Township. Shortly afterwards, the creek turns north-northeast, crosses into North Union Township again. A few tenths of a mile downstream, it reaches its confluence with Catawissa Creek.
Little Catawissa Creek joins Catawissa Creek 24.24 miles (39.01 km) upstream of its mouth.
Little Catawissa Creek