New Madrid (Spanish: Nueva Madrid) is a city in New Madrid County, Missouri, United States.
The population was 3,116 at the 2010 census.
New Madrid is the county seat of New Madrid County.
The city is located 42 miles (68 km) southwest of Cairo, Illinois, and north of an exclave of Fulton County, Kentucky, across the Mississippi River.

The town is on the north side of the Kentucky Bend in the Mississippi River, which is also known as "New Madrid Bend" or "Madrid Bend."
The river curves in an oxbow around an exclave of Fulton County, Kentucky.
Scientists expect the river eventually to cut across the neck of the peninsula and make a more direct channel, leaving the Kentucky territory as an island.

New Madrid was the epicenter of the very powerful 1811–12 New Madrid earthquakes.
New Madrid (Spanish: Nueva Madrid) is a city in New Madrid County, Missouri, United States. The population was 3,116 at the 2010 census. New Madrid is the county seat of New Madrid County. The city is located 42 miles (68 km) southwest of Cairo, Illinois, and north of an exclave of Fulton County, Kentucky, across the Mississippi River.
The town is on the north side of the Kentucky Bend in the Mississippi River, which is also known as "New Madrid Bend" or "Madrid Bend." The river curves in an oxbow around an exclave of Fulton County, Kentucky. Scientists expect the river eventually to cut across the neck of the peninsula and make a more direct channel, leaving the Kentucky territory as an island.
New Madrid was the epicenter of the very powerful 1811–12 New Madrid earthquakes.
New Madrid, Missouri