SLC7A11 is a member of a heterodimeric Na+-independent anionic amino acid transport system highly specific for cystine and glutamate.
This antiporter imports cystine and exports glutamate, which are both amino acids.
An antiporter functions with a one-to-one counter-transport, which is when one substance is transported across the membrane at the same time another substance is transported across the membrane in the opposite direction.
The antiporter is a heterodimeric amino acid transporter.
The structure of this protein includes two chains: a specific light chain, xCT, and a heavy chain, 4F2, which are linked by a disulfide bridge.
The xCT chain has 12 transmembrane domains consisting of 501 amino acids, and the 4F2 chain appears to be highly conserved among transporters.
The human xCT has an 89% similarity of amino acids to a mouse xCT.
The complementary DNA, cDNA, has a total of 9648 base pairs.
The SLC7A11 gene has been found not only in the brain, but has also been found to be expressed in the spinal cord, pancreas, and in glioma cells.
SLC7A11 is a member of a heterodimeric Na+-independent anionic amino acid transport system highly specific for cystine and glutamate. This antiporter imports cystine and exports glutamate, which are both amino acids. An antiporter functions with a one-to-one counter-transport, which is when one substance is transported across the membrane at the same time another substance is transported across the membrane in the opposite direction. The antiporter is a heterodimeric amino acid transporter. The structure of this protein includes two chains: a specific light chain, xCT, and a heavy chain, 4F2, which are linked by a disulfide bridge. The xCT chain has 12 transmembrane domains consisting of 501 amino acids, and the 4F2 chain appears to be highly conserved among transporters. The human xCT has an 89% similarity of amino acids to a mouse xCT. The complementary DNA, cDNA, has a total of 9648 base pairs. The SLC7A11 gene has been found not only in the brain, but has also been found to be expressed in the spinal cord, pancreas, and in glioma cells.
Cystine/glutamate transporter