He then studied law in the office of Jared Ingersoll (1749–1822), who had been a member of the Constitutional convention of 1787, and who, from 1791 to 1800 and again from 1811 to 1816, was the attorney-general of Pennsylvania.
 In 1800, Binney was admitted to the bar in Philadelphia and practiced there with great success for half a century, and was recognized as one of the leaders of the bar in Pennsylvania and the United States.

Between 1806–1807, he served in the Pennsylvania legislature.
From 1833 until 1835, he served as a Whig member of the United States House of Representatives.
 While in the House of Representatives, he defended the United States Bank and opposed the policies of President Andrew Jackson.

After leaving office, he returned to the practice of law.
 Binney's most famous cases were Lyle v. Richards (1823), and Vidal et al v. Philadelphia et al (1844).
In the latter case, which involved the disposition of the fortune of Stephen Girard, he was unsuccessfully opposed by Daniel Webster.
Binney's argument in this case greatly influenced the interpretation of the law of charities.
He then studied law in the office of Jared Ingersoll (1749–1822), who had been a member of the Constitutional convention of 1787, and who, from 1791 to 1800 and again from 1811 to 1816, was the attorney-general of Pennsylvania.  In 1800, Binney was admitted to the bar in Philadelphia and practiced there with great success for half a century, and was recognized as one of the leaders of the bar in Pennsylvania and the United States. 
Between 1806–1807, he served in the Pennsylvania legislature. From 1833 until 1835, he served as a Whig member of the United States House of Representatives.  While in the House of Representatives, he defended the United States Bank and opposed the policies of President Andrew Jackson.
After leaving office, he returned to the practice of law.  Binney's most famous cases were Lyle v. Richards (1823), and Vidal et al v. Philadelphia et al (1844). In the latter case, which involved the disposition of the fortune of Stephen Girard, he was unsuccessfully opposed by Daniel Webster. Binney's argument in this case greatly influenced the interpretation of the law of charities.
Horace Binney