The site for the church was given by Edward Smith-Stanley, 12th Earl of Derby in 1791 on condition that the land should never be used for any other purpose than that of a church.
Plans for the design of the church were first drawn up in 1802 by John Foster, senior, the surveyor of the Corporation of Liverpool, but the foundation stone was not laid until April 9, 1811.
Building work, supervised by Foster, progressed slowly, and during this time the plans were amended to make the building suitable both as a ceremonial place of worship for members of the Corporation, and also for use as a concert hall.
In 1822 it was decided to add a chancel to the church.
Foster's son, also named John, took over the role of Corporation surveyor and continued to supervise the building, making further changes to the design in 1827.
Building was finally completed in 1832.
The church was known as "the doctor's church" because of its location near to Rodney Street, the home of many doctors.
It continued to be used as a concert hall as well as a church until the Philharmonic Hall in Hope Street opened in 1849.
Between 1864 and 1873 minor alterations were made to the church by W. & G. Audsley.

On 6 May 1941, during Liverpool's "May Blitz", the church was hit by an incendiary device that caused a large fire, leaving only the burnt-out shell of the former church.
It has since been nicknamed "the bombed-out church".
It has been decided to maintain the church as it is, a burnt-out shell, as a memorial to those who died as a result of the war.
The church was designated as a Grade II* listed building on 28 June 1952.
This is the middle of the three grades, which is defined by English Heritage as containing "particularly important buildings of more than special interest".
The site for the church was given by Edward Smith-Stanley, 12th Earl of Derby in 1791 on condition that the land should never be used for any other purpose than that of a church. Plans for the design of the church were first drawn up in 1802 by John Foster, senior, the surveyor of the Corporation of Liverpool, but the foundation stone was not laid until April 9, 1811. Building work, supervised by Foster, progressed slowly, and during this time the plans were amended to make the building suitable both as a ceremonial place of worship for members of the Corporation, and also for use as a concert hall. In 1822 it was decided to add a chancel to the church. Foster's son, also named John, took over the role of Corporation surveyor and continued to supervise the building, making further changes to the design in 1827. Building was finally completed in 1832. The church was known as "the doctor's church" because of its location near to Rodney Street, the home of many doctors. It continued to be used as a concert hall as well as a church until the Philharmonic Hall in Hope Street opened in 1849. Between 1864 and 1873 minor alterations were made to the church by W. & G. Audsley.
On 6 May 1941, during Liverpool's "May Blitz", the church was hit by an incendiary device that caused a large fire, leaving only the burnt-out shell of the former church. It has since been nicknamed "the bombed-out church". It has been decided to maintain the church as it is, a burnt-out shell, as a memorial to those who died as a result of the war. The church was designated as a Grade II* listed building on 28 June 1952. This is the middle of the three grades, which is defined by English Heritage as containing "particularly important buildings of more than special interest".
Church of St Luke, Liverpool