Notable alumni of the school include:
Ted Ashley (1922–2002), chairman of the Warner Bros. film studio and founder of the Ashley-Famous talent agency
Tony Consiglio (born 1970), cartoonist.

John Gotti (1940-2002), Mafia boss who headed the Gambino crime family, after dropping out at age 16.

José Greco (1918-2000), dancer / choreographer.

Bob Grim (1930-1996), major league baseball player
Richie Havens (1941-2013), singer-songwriter and guitarist (dropped out)
William "Red" Holzman (1920-1998), NBA 2-time All-Star Basketball Player, Coach, and Hall of Famer.

Shelley Hirsch (born 1952), avant-garde singer / performer.

Earle Hyman (1926-2017), actor
Anne Jackson (1925-2016, class of 1943), actress.

Alfred Kazin (1915-1998), writer
Sam Levenson (1911-1980), writer / television host/ journalist.

Dan Schneider (born 1965), poet and critic.

Peter Senerchia (born 1967), professional wrestler known as Tazz.

DJ Spinderella (born 1971), member of the hip-hop group Salt-n-Pepa.

Franklin A. Thomas (born 1934), former President and CEO of the Ford Foundation.
Notable alumni of the school include:
Ted Ashley (1922–2002), chairman of the Warner Bros. film studio and founder of the Ashley-Famous talent agency
Tony Consiglio (born 1970), cartoonist.
John Gotti (1940-2002), Mafia boss who headed the Gambino crime family, after dropping out at age 16.
José Greco (1918-2000), dancer / choreographer.
Bob Grim (1930-1996), major league baseball player
Richie Havens (1941-2013), singer-songwriter and guitarist (dropped out)
William "Red" Holzman (1920-1998), NBA 2-time All-Star Basketball Player, Coach, and Hall of Famer.
Shelley Hirsch (born 1952), avant-garde singer / performer.
Earle Hyman (1926-2017), actor
Anne Jackson (1925-2016, class of 1943), actress.
Alfred Kazin (1915-1998), writer
Sam Levenson (1911-1980), writer / television host/ journalist.
Dan Schneider (born 1965), poet and critic.
Peter Senerchia (born 1967), professional wrestler known as Tazz.
DJ Spinderella (born 1971), member of the hip-hop group Salt-n-Pepa.
Franklin A. Thomas (born 1934), former President and CEO of the Ford Foundation.
Franklin K. Lane High School