Barber was selected in the sixth round (173rd overall) of the 2008 NFL Draft by the Houston Texans.
He appeared in 12 games (no starts) his rookie season, recording 15 tackles, a sack, and a pass deflection.

Barber played in 13 games (six starts) for the Texans in 2009 before being placed on injured reserve with a hamstring injury on December 2.
He finished the season with 33 tackles and his first career interception.
Barber was selected in the sixth round (173rd overall) of the 2008 NFL Draft by the Houston Texans. He appeared in 12 games (no starts) his rookie season, recording 15 tackles, a sack, and a pass deflection.
Barber played in 13 games (six starts) for the Texans in 2009 before being placed on injured reserve with a hamstring injury on December 2. He finished the season with 33 tackles and his first career interception.
Dominique Barber