In 2010, Dame Edna collaborated with cabaret pianist and singer Michael Feinstein for a two-person revue in the United States, titled "All About Me", based on the premise that the pair were rivals who were forced to work together for the show's sake.
The show opened as the second production for the newly refurbished Henry Miller's Theatre and was planned to run from 18 March through 18 July 2010 (with previews beginning on 22 February), but lukewarm reviews and low ticket sales led to the limited engagement being cut short and closing on 4 April 2010, after 27 previews and 20 regular performances.
On 25 March 2010, she appeared on the television talk show The View as a guest host to promote the production.

On 29 April 2011 she appeared on the BBC-1 broadcast "William and Kate: The Royal Wedding", with Karl Stefanovic and Lisa Wilkinson, covering the wedding of Prince William and Catherine Middleton at Buckingham Palace, along with Tracy Grimshaw and Kathy Lette at Westminster Abbey.

On 18 March 2012, Humphries announced he would "retire" the Dame Edna character because he was "beginning to feel a bit senior".

On 15 March 2013, Dame Edna Everage appeared on Red Nose Day 2013 as a guest star and judge for the Comic Relief Does MasterChef competition between Jack Whitehall and Micky Flanagan.

In June 2013, Dame Edna returned in a Sydney Opera House production of Peter and the Wolf.

In 2013, Dame Edna announced her final tour of the United Kingdom.
 The show opened in November 2013 at the London Palladium before beginning a UK tour in January 2014.

On 11 February 2015 she appeared on The Great Comic Relief Bake Off in aid of Comic Relief.

"Dame Edna's Glorious Goodbye – The Farewell Tour" – began in Seattle, Washington at The Moore Theatre (15–18 January 2015) and continued on to The Ahmanson Theatre in Los Angeles (24 January 2015 through 15 March 2015) next traveling to San Francisco's Orpheum Theater (17–22 March 2015) then on to the McCallum Theatre in Palm Desert, California (30 March 2015 – 4 April 2015) then Toronto, Ontario, Canada's Princess of Wales Theatre (9–19 April 2015) and concluding in Washington, DC at the National Theatre (21–26 April 2015.)

Dame Edna was a guest on Michael McIntyre's Big Christmas Show, broadcast by BBC1 on Christmas Day 2015.

Dame Edna appeared briefly in Absolutely Fabulous: The Movie (2016) in a non-speaking cameo, one of two characters played by Humphries in the film.

On Thursday 19 September 2019, Dame Edna appeared on the Today programme with John Humphreys.
This was John Humphreys final programme as presenter.

Dame Edna returned to the BBC for a one-off special where she (belatedly) publicly acknowledged the death of Madge in her 2019 TV special Dame Edna Rules The Waves, first broadcast on BBC1, 31 December 2019.
During the show, Dame Edna attempts to dispose of Madge's ashes from the porthole of her luxury yacht, The Ocean Widow, but is prevented from doing so to protect the environment.
Madge's last will and testament insisted that Dame Edna took on the care of her sister Mabel, who has now become Dame Edna's silent sidekick, sticking labels on her celebrity guests.
Mabel is portrayed by British actress Anne Rason.
In 2010, Dame Edna collaborated with cabaret pianist and singer Michael Feinstein for a two-person revue in the United States, titled "All About Me", based on the premise that the pair were rivals who were forced to work together for the show's sake. The show opened as the second production for the newly refurbished Henry Miller's Theatre and was planned to run from 18 March through 18 July 2010 (with previews beginning on 22 February), but lukewarm reviews and low ticket sales led to the limited engagement being cut short and closing on 4 April 2010, after 27 previews and 20 regular performances. On 25 March 2010, she appeared on the television talk show The View as a guest host to promote the production.
On 29 April 2011 she appeared on the BBC-1 broadcast "William and Kate: The Royal Wedding", with Karl Stefanovic and Lisa Wilkinson, covering the wedding of Prince William and Catherine Middleton at Buckingham Palace, along with Tracy Grimshaw and Kathy Lette at Westminster Abbey.
On 18 March 2012, Humphries announced he would "retire" the Dame Edna character because he was "beginning to feel a bit senior".
On 15 March 2013, Dame Edna Everage appeared on Red Nose Day 2013 as a guest star and judge for the Comic Relief Does MasterChef competition between Jack Whitehall and Micky Flanagan.
In June 2013, Dame Edna returned in a Sydney Opera House production of Peter and the Wolf.
In 2013, Dame Edna announced her final tour of the United Kingdom.  The show opened in November 2013 at the London Palladium before beginning a UK tour in January 2014.
On 11 February 2015 she appeared on The Great Comic Relief Bake Off in aid of Comic Relief.
"Dame Edna's Glorious Goodbye – The Farewell Tour" – began in Seattle, Washington at The Moore Theatre (15–18 January 2015) and continued on to The Ahmanson Theatre in Los Angeles (24 January 2015 through 15 March 2015) next traveling to San Francisco's Orpheum Theater (17–22 March 2015) then on to the McCallum Theatre in Palm Desert, California (30 March 2015 – 4 April 2015) then Toronto, Ontario, Canada's Princess of Wales Theatre (9–19 April 2015) and concluding in Washington, DC at the National Theatre (21–26 April 2015.)
Dame Edna was a guest on Michael McIntyre's Big Christmas Show, broadcast by BBC1 on Christmas Day 2015.
Dame Edna appeared briefly in Absolutely Fabulous: The Movie (2016) in a non-speaking cameo, one of two characters played by Humphries in the film.
On Thursday 19 September 2019, Dame Edna appeared on the Today programme with John Humphreys. This was John Humphreys final programme as presenter.
Dame Edna returned to the BBC for a one-off special where she (belatedly) publicly acknowledged the death of Madge in her 2019 TV special Dame Edna Rules The Waves, first broadcast on BBC1, 31 December 2019. During the show, Dame Edna attempts to dispose of Madge's ashes from the porthole of her luxury yacht, The Ocean Widow, but is prevented from doing so to protect the environment. Madge's last will and testament insisted that Dame Edna took on the care of her sister Mabel, who has now become Dame Edna's silent sidekick, sticking labels on her celebrity guests. Mabel is portrayed by British actress Anne Rason.
Dame Edna Everage