On 10 October 2001, 2–153 IN "Gunslinger" was activated in support of the Global War on Terror.
Second Battalion was sent to Egypt in order to take over the Multinational Force and Observers mission, freeing up regular army infantry units to deploy to Afghanistan.

The 2-153's mission during the MFO was: "...to supervise the implementation of the security provisions of the Egyptian-Israeli Treaty of Peace and employ best efforts to prevent any violation of its terms."
This mission was accomplished by carrying out four tasks:
Operating checkpoints, observation posts and conducting reconnaissance patrols on the international border as well as within Zone C; verification of the terms of the peace treaty not less than twice a month; verification of the terms of the peace treaty within forty eight hours, upon the request of either party, and ensuring freedom of international marine navigation in the Strait of Tiran and access to the Gulf of Aqaba.

This was the first "pure" National Guard takeover of the MFO mission.
2-153rd deactivated on 11 October 2002.
On 10 October 2001, 2–153 IN "Gunslinger" was activated in support of the Global War on Terror. Second Battalion was sent to Egypt in order to take over the Multinational Force and Observers mission, freeing up regular army infantry units to deploy to Afghanistan.
The 2-153's mission during the MFO was: "...to supervise the implementation of the security provisions of the Egyptian-Israeli Treaty of Peace and employ best efforts to prevent any violation of its terms." This mission was accomplished by carrying out four tasks:
Operating checkpoints, observation posts and conducting reconnaissance patrols on the international border as well as within Zone C; verification of the terms of the peace treaty not less than twice a month; verification of the terms of the peace treaty within forty eight hours, upon the request of either party, and ensuring freedom of international marine navigation in the Strait of Tiran and access to the Gulf of Aqaba.
This was the first "pure" National Guard takeover of the MFO mission. 2-153rd deactivated on 11 October 2002.
2nd Battalion, 153rd Infantry Regiment (United States)