Dibasic calcium phosphate is produced by the neutralization of calcium hydroxide with phosphoric acid, which precipitates the dihydrate as a solid.
At 60 °C the anhydrous form is precipitated:
H₃PO₄ + Ca(OH)₂ → CaHPO₄
To prevent degradation that would form hydroxyapatite, sodium pyrophosphate or trimagnesium phosphate octahydrate are added when for example, dibasic calcium phosphate dihydrate is to be used as a polishing agent in toothpaste.

In a continuous process CaCl₂ can be treated with (NH₄)₂HPO₄ to form the dihydrate:
CaCl₂ + (NH₄)₂HPO₄ → CaHPO₄•2H₂O
A slurry of the dihydrate is then heated to around 65–70 °C to form anhydrous CaHPO₄ as a crystalline precipitate, typically as flat diamondoid crystals, which are suitable for further processing.

Dibasic calcium phosphate dihydrate is formed in "brushite" calcium phosphate cements (CPC's), which have medical applications.
An example of the overall setting reaction in the formation of  "β-TCP/MCPM" (β-tricalcium phosphate/monocalcium phosphate) calcium phosphate cements is:
Ca₃(PO₄)₂ + Ca(H₂PO₄)₂•H₂O + 7 H₂O → 4 CaHPO₄•2H₂O
Dibasic calcium phosphate is produced by the neutralization of calcium hydroxide with phosphoric acid, which precipitates the dihydrate as a solid. At 60 °C the anhydrous form is precipitated:
H₃PO₄ + Ca(OH)₂ → CaHPO₄
To prevent degradation that would form hydroxyapatite, sodium pyrophosphate or trimagnesium phosphate octahydrate are added when for example, dibasic calcium phosphate dihydrate is to be used as a polishing agent in toothpaste.
In a continuous process CaCl₂ can be treated with (NH₄)₂HPO₄ to form the dihydrate:
CaCl₂ + (NH₄)₂HPO₄ → CaHPO₄•2H₂O
A slurry of the dihydrate is then heated to around 65–70 °C to form anhydrous CaHPO₄ as a crystalline precipitate, typically as flat diamondoid crystals, which are suitable for further processing.
Dibasic calcium phosphate dihydrate is formed in "brushite" calcium phosphate cements (CPC's), which have medical applications. An example of the overall setting reaction in the formation of  "β-TCP/MCPM" (β-tricalcium phosphate/monocalcium phosphate) calcium phosphate cements is:
Ca₃(PO₄)₂ + Ca(H₂PO₄)₂•H₂O + 7 H₂O → 4 CaHPO₄•2H₂O
Dicalcium phosphate