In the season opener against the Cleveland Browns, Henry rushed 19 times for 84 yards and a touchdown.
He also caught one pass for a 75-yard touchdown as the Titans won on the road 43–13.
During Week 2 against the Indianapolis Colts, he rushed 15 times for 81 yards and a touchdown as the Titans narrowly lost 19–17.
Two weeks later against the Atlanta Falcons, Henry had his first 100-yard game of the season when he rushed for 100 yards on 27 carries in a 24–10 road victory.
In the next game against the Buffalo Bills, he rushed for 78 yards and a touchdown as the Titans lost by a score of 14–7.
After a season-low 28 yards in a Week 6 shutout loss to Denver, Henry sank to 12th in the league in rushing, over 200 yards behind the league leaders he would eventually catch.
Henry responded with 90 rushing yards and a touchdown in a 23–20 victory against the Los Angeles Chargers in Week 7.
During Week 9 against the Carolina Panthers, Henry rushed 13 times for 63 yards and a touchdown and caught three passes for 36 yards and a touchdown in the 30–20 road loss.
In the next game against the Kansas City Chiefs, he finished with 188 rushing yards and two touchdowns as the Titans narrowly won 35–32.
Henry won the FedEx Ground Player of the Week for his efforts.
During a Jaguars rematch in Week 12 after a Week 11 bye, Henry had a 74-yard rushing touchdown in the third quarter.
Overall, he finished the 42–20 victory with 159 rushing yards and two touchdowns along with one reception for 16 yards.
In the next game, a rematch against the Colts, he rushed 26 times for 149 yards and a touchdown in the 31–17 road victory.
During Week 14 against the Oakland Raiders, Henry rushed for 103 yards and two touchdowns in the 42–21 road victory.
During the season finale against the Houston Texans in Week 17, Henry finished with 211 rushing yards and three touchdowns as the Titans won 35–14 and made it to the playoffs as a Wild card team.
During the game, Henry narrowly won the 2019 rushing title over Nick Chubb of the Cleveland Browns, with the winning rush being a 53-yard touchdown run.
This was Henry's first career rushing crown and the first Titan to win it since Chris Johnson in 2009.

Henry finished the regular season setting career-highs in carries with 303, rushing yards with 1,540, and rushing touchdowns with 16, which all led the league, despite only playing in 15 games, missing the Week 16 game against the New Orleans Saints due to a hamstring injury.
He also set career-highs in receptions with 16, receiving yards with 206, and receiving touchdowns with two.
 On December 17, 2019, he was selected to his first Pro Bowl.
On January 3, 2020, he was named to the second-team All-Pro at both the running back and flex position, both behind Christian McCaffrey.

With the Titans finishing the season 9–7, the team narrowly clinched a wild card spot for the #6 seed.
In the AFC Wild Card game against the defending Super Bowl champion New England Patriots, which was played on his 26th birthday, Henry rushed for over 100 yards and a touchdown in the first half, finishing with 182 yards (the most ever against a Bill Belichick-led team, and the third most ever in a postseason road game) and a 22-yard reception in the 20–13 victory.
Henry became the first rushing champion with a 100-yard playoff game since Terrell Davis in 1998, the first to win a playoff game since LaDainian Tomlinson in 2007, and the second Titan with multiple post-season 100+ rushing games.
He also broke his own franchise record for most yards-from-scrimmage with 204.
During the AFC Divisional Round against the Baltimore Ravens, Henry rushed 30 times for 195 yards and threw a 3-yard touchdown pass to wide receiver Corey Davis in the 28–12 win.
He became the second player in NFL history with three postseason games with at least 150 rushing yards, joining Terrell Davis, who had four.
In addition, he became the only player with at least 175 rushing yards in consecutive games.
Davis is the only other with two such games in a career.

In the AFC Championship game against the Kansas City Chiefs, He
In the season opener against the Cleveland Browns, Henry rushed 19 times for 84 yards and a touchdown. He also caught one pass for a 75-yard touchdown as the Titans won on the road 43–13. During Week 2 against the Indianapolis Colts, he rushed 15 times for 81 yards and a touchdown as the Titans narrowly lost 19–17. Two weeks later against the Atlanta Falcons, Henry had his first 100-yard game of the season when he rushed for 100 yards on 27 carries in a 24–10 road victory. In the next game against the Buffalo Bills, he rushed for 78 yards and a touchdown as the Titans lost by a score of 14–7. After a season-low 28 yards in a Week 6 shutout loss to Denver, Henry sank to 12th in the league in rushing, over 200 yards behind the league leaders he would eventually catch. Henry responded with 90 rushing yards and a touchdown in a 23–20 victory against the Los Angeles Chargers in Week 7. During Week 9 against the Carolina Panthers, Henry rushed 13 times for 63 yards and a touchdown and caught three passes for 36 yards and a touchdown in the 30–20 road loss. In the next game against the Kansas City Chiefs, he finished with 188 rushing yards and two touchdowns as the Titans narrowly won 35–32. Henry won the FedEx Ground Player of the Week for his efforts. During a Jaguars rematch in Week 12 after a Week 11 bye, Henry had a 74-yard rushing touchdown in the third quarter. Overall, he finished the 42–20 victory with 159 rushing yards and two touchdowns along with one reception for 16 yards. In the next game, a rematch against the Colts, he rushed 26 times for 149 yards and a touchdown in the 31–17 road victory. During Week 14 against the Oakland Raiders, Henry rushed for 103 yards and two touchdowns in the 42–21 road victory. During the season finale against the Houston Texans in Week 17, Henry finished with 211 rushing yards and three touchdowns as the Titans won 35–14 and made it to the playoffs as a Wild card team. During the game, Henry narrowly won the 2019 rushing title over Nick Chubb of the Cleveland Browns, with the winning rush being a 53-yard touchdown run. This was Henry's first career rushing crown and the first Titan to win it since Chris Johnson in 2009.
Henry finished the regular season setting career-highs in carries with 303, rushing yards with 1,540, and rushing touchdowns with 16, which all led the league, despite only playing in 15 games, missing the Week 16 game against the New Orleans Saints due to a hamstring injury. He also set career-highs in receptions with 16, receiving yards with 206, and receiving touchdowns with two.  On December 17, 2019, he was selected to his first Pro Bowl. On January 3, 2020, he was named to the second-team All-Pro at both the running back and flex position, both behind Christian McCaffrey.
With the Titans finishing the season 9–7, the team narrowly clinched a wild card spot for the #6 seed. In the AFC Wild Card game against the defending Super Bowl champion New England Patriots, which was played on his 26th birthday, Henry rushed for over 100 yards and a touchdown in the first half, finishing with 182 yards (the most ever against a Bill Belichick-led team, and the third most ever in a postseason road game) and a 22-yard reception in the 20–13 victory. Henry became the first rushing champion with a 100-yard playoff game since Terrell Davis in 1998, the first to win a playoff game since LaDainian Tomlinson in 2007, and the second Titan with multiple post-season 100+ rushing games. He also broke his own franchise record for most yards-from-scrimmage with 204. During the AFC Divisional Round against the Baltimore Ravens, Henry rushed 30 times for 195 yards and threw a 3-yard touchdown pass to wide receiver Corey Davis in the 28–12 win. He became the second player in NFL history with three postseason games with at least 150 rushing yards, joining Terrell Davis, who had four. In addition, he became the only player with at least 175 rushing yards in consecutive games. Davis is the only other with two such games in a career.
In the AFC Championship game against the Kansas City Chiefs, He
Derrick Henry