Margaret was born at Farleigh Hungerford Castle in Somerset, the only surviving daughter of George Plantagenet, 1st Duke of Clarence, and his wife Isabel Neville, who was the elder daughter of Richard Neville, 16th Earl of Warwick, and his wife Anne de Beauchamp, 16th Countess of Warwick.
Her maternal grandfather was killed fighting against her uncle, Edward IV, at the Battle of Barnet.
Her father, already Duke of Clarence, was then created Earl of Salisbury and of Warwick.
Edward IV declared that Margaret's younger brother Edward should be known as Earl of Warwick as a courtesy title, but no peerage was ever created for him.
Margaret would have had a claim to the Earldom of Warwick, but the earldom was forfeited on the attainder of her brother Edward.

Margaret's mother died when she was three, and her father had two servants killed whom he thought had poisoned her.
George plotted against Edward IV, and was attainted and executed for treason; his lands and titles were forfeited.
Edward IV died when Margaret was ten, and her uncle Richard, Duke of Gloucester, declared that Edward's marriage was invalid, his children illegitimate, and that Margaret and her brother Edward were debarred from the throne by their father's attainder.
Married to Anne Neville, younger sister to Margaret's mother Isabel, Richard assumed the throne himself as Richard III.

Richard III sent the children to Sheriff Hutton Castle in Yorkshire.
He was defeated and killed in 1485 at the Battle of Bosworth by Henry Tudor, who succeeded him as Henry VII.
The new king married Margaret's cousin Elizabeth of York, Edward IV's daughter, and Margaret and her brother were taken into their care.
Soon young Edward, a potential York claimant to the throne, was moved to the Tower of London.
Edward was briefly displayed in public at St Paul's Cathedral in 1487 in response to the presentation of the impostor Lambert Simnel as the "Earl of Warwick" to the Irish lords.
Shortly thereafter, probably in November 1487, Henry VII gave Margaret in marriage to his cousin, Sir Richard Pole, whose mother was half-sister of the king's mother, Margaret Beaufort.
When Perkin Warbeck impersonated Edward IV's presumed-dead son Richard of Shrewsbury, 1st Duke of York, in 1499, Margaret's brother Edward was attainted and executed for involvement in the plot.
Richard Pole held a variety of offices in Henry VII's government, the highest being Chamberlain for Arthur, Prince of Wales, Henry's elder son.
When Arthur married Catherine of Aragon, Margaret became one of her ladies-in-waiting, but her entourage was dissolved when the teenaged Arthur died in 1502.

When her husband died in 1505, Margaret was a widow with five children, a limited amount of land inherited from her husband, no other income and no prospects.
Henry VII paid for Richard's funeral.
To ease the situation, Margaret devoted her third son Reginald Pole to the Church, where he was to have an eventful career as a papal Legate and later Archbishop of Canterbury.
Nonetheless, he was to resent her abandonment of him bitterly in later life.
 Additionally, Margaret, without adequate means to support herself and her children, was forced to live at Syon Abbey among Bridgettine nuns after her husband's death.
She was to remain there until she returned to favour at the ascension of Henry VIII in 1509.
Margaret was born at Farleigh Hungerford Castle in Somerset, the only surviving daughter of George Plantagenet, 1st Duke of Clarence, and his wife Isabel Neville, who was the elder daughter of Richard Neville, 16th Earl of Warwick, and his wife Anne de Beauchamp, 16th Countess of Warwick. Her maternal grandfather was killed fighting against her uncle, Edward IV, at the Battle of Barnet. Her father, already Duke of Clarence, was then created Earl of Salisbury and of Warwick. Edward IV declared that Margaret's younger brother Edward should be known as Earl of Warwick as a courtesy title, but no peerage was ever created for him. Margaret would have had a claim to the Earldom of Warwick, but the earldom was forfeited on the attainder of her brother Edward.
Margaret's mother died when she was three, and her father had two servants killed whom he thought had poisoned her. George plotted against Edward IV, and was attainted and executed for treason; his lands and titles were forfeited. Edward IV died when Margaret was ten, and her uncle Richard, Duke of Gloucester, declared that Edward's marriage was invalid, his children illegitimate, and that Margaret and her brother Edward were debarred from the throne by their father's attainder. Married to Anne Neville, younger sister to Margaret's mother Isabel, Richard assumed the throne himself as Richard III.
Richard III sent the children to Sheriff Hutton Castle in Yorkshire. He was defeated and killed in 1485 at the Battle of Bosworth by Henry Tudor, who succeeded him as Henry VII. The new king married Margaret's cousin Elizabeth of York, Edward IV's daughter, and Margaret and her brother were taken into their care. Soon young Edward, a potential York claimant to the throne, was moved to the Tower of London. Edward was briefly displayed in public at St Paul's Cathedral in 1487 in response to the presentation of the impostor Lambert Simnel as the "Earl of Warwick" to the Irish lords. Shortly thereafter, probably in November 1487, Henry VII gave Margaret in marriage to his cousin, Sir Richard Pole, whose mother was half-sister of the king's mother, Margaret Beaufort. When Perkin Warbeck impersonated Edward IV's presumed-dead son Richard of Shrewsbury, 1st Duke of York, in 1499, Margaret's brother Edward was attainted and executed for involvement in the plot. Richard Pole held a variety of offices in Henry VII's government, the highest being Chamberlain for Arthur, Prince of Wales, Henry's elder son. When Arthur married Catherine of Aragon, Margaret became one of her ladies-in-waiting, but her entourage was dissolved when the teenaged Arthur died in 1502.
When her husband died in 1505, Margaret was a widow with five children, a limited amount of land inherited from her husband, no other income and no prospects. Henry VII paid for Richard's funeral. To ease the situation, Margaret devoted her third son Reginald Pole to the Church, where he was to have an eventful career as a papal Legate and later Archbishop of Canterbury. Nonetheless, he was to resent her abandonment of him bitterly in later life.  Additionally, Margaret, without adequate means to support herself and her children, was forced to live at Syon Abbey among Bridgettine nuns after her husband's death. She was to remain there until she returned to favour at the ascension of Henry VIII in 1509.
Margaret Pole, Countess of Salisbury