In Week 2 against the Tennessee Titans, Leonard made 10 tackles and 1 sack on Marcus Mariota as the Colts won 19–17.

After the game, Leonard reportedly felt concussion like symptoms and was forced to miss the next three games.
 He made his return in week 7 against the Houston Texans.
 In the game, Leonard recorded a team high 10 tackles and an interception off Deshaun Watson in the 30–23 win.
In Week 10 against the Miami Dolphins, Leonard recorded a team high 13 tackles, sacked Ryan Fitzpatrick once, intercepted a pass thrown by Fitzpatrick, and forced a fumble on tight end Mike Gesicki which was recovered by teammate Kenny Moore in the 16–12 loss.

In Week 13 against the Tennessee Titans, Leonard recorded 12 tackles and sacked Ryan Tannehill twice in the 31–17 loss.
In Week 14, against the Tampa Bay Buccaneers, Leonard recorded 9 tackles and intercepted 2 passes thrown by Jameis Winston, one of which was returned for an 80 yard pick six, during the 38–35 loss.

Following the season, he was voted into his first Pro Bowl appearance.
Despite missing three games due to injury, Leonard had a team-leading 121 tackles including 71 solos, six tackles for loss, five sacks, six passes defended, five interceptions, and two forced fumbles.
He also became the first NFL player since 1982 to have 10-plus sacks and five-plus interceptions in his first 25 games.
In Week 2 against the Tennessee Titans, Leonard made 10 tackles and 1 sack on Marcus Mariota as the Colts won 19–17.
After the game, Leonard reportedly felt concussion like symptoms and was forced to miss the next three games.  He made his return in week 7 against the Houston Texans.  In the game, Leonard recorded a team high 10 tackles and an interception off Deshaun Watson in the 30–23 win. In Week 10 against the Miami Dolphins, Leonard recorded a team high 13 tackles, sacked Ryan Fitzpatrick once, intercepted a pass thrown by Fitzpatrick, and forced a fumble on tight end Mike Gesicki which was recovered by teammate Kenny Moore in the 16–12 loss.
In Week 13 against the Tennessee Titans, Leonard recorded 12 tackles and sacked Ryan Tannehill twice in the 31–17 loss. In Week 14, against the Tampa Bay Buccaneers, Leonard recorded 9 tackles and intercepted 2 passes thrown by Jameis Winston, one of which was returned for an 80 yard pick six, during the 38–35 loss.
Following the season, he was voted into his first Pro Bowl appearance. Despite missing three games due to injury, Leonard had a team-leading 121 tackles including 71 solos, six tackles for loss, five sacks, six passes defended, five interceptions, and two forced fumbles. He also became the first NFL player since 1982 to have 10-plus sacks and five-plus interceptions in his first 25 games.
Darius Leonard