John Talbot was born on 7 June 1630, the eldest surviving son of Colonel Sharington Talbot (1591–1677), and Jane Lyttelton.
He had a sister, Elizabeth (died 1709).

Related to the Earls of Shrewsbury, the Talbots' main estates were in Salwarpe, Worcestershire.
They acquired Lacock Abbey, Wiltshire through his great-grandmother, Olive, who died at the age of 97 in 1646.
Like John himself, both his uncle Sir Gilbert and father lived into their 80s, as did many other close relatives.

In 1653, he married Elizabeth Keyt, who died in childbirth in 1656, and was buried with her infant son in Stow-on-the-Wold.
He married again in 1660, this time to Barbara Slingsby (1633 – ?),
daughter of Sir Henry Slingsby, executed in 1658 for plotting against the Protectorate.
They had three daughters who lived to adulthood; Anne (1665–1720), Barbara (1671–1763), and Gilberta (1675–1746).
His estates were inherited by his grandson John Ivory-Talbot (1691–1772), son of Anne and her husband Sir John Ivory.
John Talbot was born on 7 June 1630, the eldest surviving son of Colonel Sharington Talbot (1591–1677), and Jane Lyttelton. He had a sister, Elizabeth (died 1709).
Related to the Earls of Shrewsbury, the Talbots' main estates were in Salwarpe, Worcestershire. They acquired Lacock Abbey, Wiltshire through his great-grandmother, Olive, who died at the age of 97 in 1646. Like John himself, both his uncle Sir Gilbert and father lived into their 80s, as did many other close relatives.
In 1653, he married Elizabeth Keyt, who died in childbirth in 1656, and was buried with her infant son in Stow-on-the-Wold. He married again in 1660, this time to Barbara Slingsby (1633 – ?), daughter of Sir Henry Slingsby, executed in 1658 for plotting against the Protectorate. They had three daughters who lived to adulthood; Anne (1665–1720), Barbara (1671–1763), and Gilberta (1675–1746). His estates were inherited by his grandson John Ivory-Talbot (1691–1772), son of Anne and her husband Sir John Ivory.
John Talbot of Lacock