The original hospital at Whiston was established when Prescot Poor Law Union established the Prescot Union Workhouse on Warrington Road in 1843.
In 1871 a new general hospital was built with a medical isolation unit added in 1887 for cases of cholera and other serious infectious diseases of the time.
From 1904, to protect those from disadvantage in later life, birth certificates of infants born in the workhouse simply gave their address as 1 Warrington Road, Whiston.

When the NHS was established in 1948, the hospital, then known as the County Hospital, had 6 main blocks of wards accommodating 500 patients.
Renamed Whiston Hospital in 1953, the hospital expanded its range of specialties.

In 1960 the 82 bed Burns & Plastic Surgery Unit opened and four years later an Intensive Care Unit and a Pathology Laboratory were built.
In 1973 these were joined by a Maternity & Gynaecology Unit and Postgraduate Medical Centre.
A scheme to rebuild the hospital was procured under a Private Finance Initiative contract in 2006.
The works were carried out by Vinci, as part of a scheme with St Helens Hospital, at a cost of £338 million.
To mark the completion of the project, the new hospital was officially opened by the Countess of Wessex on 24 April 2013.
The only remaining building of the former hospital is the G-Ward block (since converted for administrative and educational facilities and now known as Nightingale House) which was opened in 1996 by the late Dr Eric Sherwood-Jones, a Whiston Hospital doctor and pioneer of intensive care medicine in the UK.
The original hospital at Whiston was established when Prescot Poor Law Union established the Prescot Union Workhouse on Warrington Road in 1843. In 1871 a new general hospital was built with a medical isolation unit added in 1887 for cases of cholera and other serious infectious diseases of the time. From 1904, to protect those from disadvantage in later life, birth certificates of infants born in the workhouse simply gave their address as 1 Warrington Road, Whiston.
When the NHS was established in 1948, the hospital, then known as the County Hospital, had 6 main blocks of wards accommodating 500 patients. Renamed Whiston Hospital in 1953, the hospital expanded its range of specialties.
In 1960 the 82 bed Burns & Plastic Surgery Unit opened and four years later an Intensive Care Unit and a Pathology Laboratory were built. In 1973 these were joined by a Maternity & Gynaecology Unit and Postgraduate Medical Centre. A scheme to rebuild the hospital was procured under a Private Finance Initiative contract in 2006. The works were carried out by Vinci, as part of a scheme with St Helens Hospital, at a cost of £338 million. To mark the completion of the project, the new hospital was officially opened by the Countess of Wessex on 24 April 2013. The only remaining building of the former hospital is the G-Ward block (since converted for administrative and educational facilities and now known as Nightingale House) which was opened in 1996 by the late Dr Eric Sherwood-Jones, a Whiston Hospital doctor and pioneer of intensive care medicine in the UK.
Whiston Hospital