Borstein has made several supporting appearances in such comedic films as Killers (2010), Dinner for Schmucks (2010), Ted (2012), ParaNorman (2012), A Million Ways to Die in the West (2014), and The Angry Birds Movie (2016).

In 2010, Borstein joined the first season staff of the Showtime comedy-drama series Shameless, as a writer and supervising producer.
In its second season, she held the position of writer and consulting producer.
She also guest-starred as Lou Deckner in numerous episodes of the series, beginning in the first season episode "But at Last Came a Knock."

She also appeared as a comedian contestant on IFC's short-lived comedy-driven game show Bunk in 2012.

Borstein later starred as Dawn Forchette on the HBO comedy series Getting On, which is a remake of a UK series of the same name.
The series has gained positive reviews and earned multiple Primetime Emmy Award nominations.
It aired from 2013 to 2015.

In 2017, Borstein began starring as Susie Myerson in the historical comedy-drama series The Marvelous Mrs. Maisel, for which she received significant critical acclaim and won two Primetime Emmy Awards for Outstanding Supporting Actress in a Comedy Series.
Borstein has made several supporting appearances in such comedic films as Killers (2010), Dinner for Schmucks (2010), Ted (2012), ParaNorman (2012), A Million Ways to Die in the West (2014), and The Angry Birds Movie (2016).
In 2010, Borstein joined the first season staff of the Showtime comedy-drama series Shameless, as a writer and supervising producer. In its second season, she held the position of writer and consulting producer. She also guest-starred as Lou Deckner in numerous episodes of the series, beginning in the first season episode "But at Last Came a Knock."
She also appeared as a comedian contestant on IFC's short-lived comedy-driven game show Bunk in 2012.
Borstein later starred as Dawn Forchette on the HBO comedy series Getting On, which is a remake of a UK series of the same name. The series has gained positive reviews and earned multiple Primetime Emmy Award nominations. It aired from 2013 to 2015.
In 2017, Borstein began starring as Susie Myerson in the historical comedy-drama series The Marvelous Mrs. Maisel, for which she received significant critical acclaim and won two Primetime Emmy Awards for Outstanding Supporting Actress in a Comedy Series.
Alex Borstein