Eddie McClintock as Pete Lattimer is a "rule-bender" Secret Service Agent, now assigned to Warehouse 13.
 He has been able to pick up "vibes", both good and bad, since he was a child.
The series frequently makes references to his being a recovering alcoholic who already had been sober for more than eight years when the series started.
He is also more than a little fond of cookies.

Joanne Kelly as Myka Bering, once a rising star in the Secret Service, is a by-the-book agent.
 She has a scrupulous eye for detail and possesses an eidetic memory.
She also has extensive knowledge of books, having grown up in a book store.
Reference to a former partner that ended in tragedy is frequently made, such as in the season one episode "Regrets".

Saul Rubinek as Artie Nielsen is the Special Agent in Charge at Warehouse 13.
 A former cryptographer and codebreaker for the NSA, he has spent over 30 years at the Warehouse and is very knowledgeable about artifacts, both in the Warehouse and out in the world.
He becomes a surrogate father to Claudia.

Genelle Williams as Leena (seasons 1–4; guest season 5), the proprietor of the bed and breakfast in nearby Univille, where the team lives.
She can read a person's aura.

Simon Reynolds as Daniel Dickinson (season 1; guest season 2), Pete and Myka's former boss in Washington, D.C.
Allison Scagliotti as Claudia Donovan (seasons 2–5; recurring season 1) is described as a "young, hip, brilliant techno-wiz" who earns a job at Warehouse 13 after discovering too many of its secrets.
She can hack into almost any computer network and occasionally modifies artifacts to suit her needs.

Aaron Ashmore as Steve Jinks (seasons 4–5; recurring season 3)  was an ATF agent before being recruited to Warehouse 13 for his ability to know if people are lying.
In "Emily Lake" he is killed by Marcus Diamond (Sasha Roiz) on orders of Walter Sykes (Anthony Michael Hall).
In season 4, he is resurrected by Claudia using the metronome.
Ashmore was promoted to series regular beginning with the episode "Personal Effects".
Eddie McClintock as Pete Lattimer is a "rule-bender" Secret Service Agent, now assigned to Warehouse 13.  He has been able to pick up "vibes", both good and bad, since he was a child. The series frequently makes references to his being a recovering alcoholic who already had been sober for more than eight years when the series started. He is also more than a little fond of cookies.
Joanne Kelly as Myka Bering, once a rising star in the Secret Service, is a by-the-book agent.  She has a scrupulous eye for detail and possesses an eidetic memory. She also has extensive knowledge of books, having grown up in a book store. Reference to a former partner that ended in tragedy is frequently made, such as in the season one episode "Regrets".
Saul Rubinek as Artie Nielsen is the Special Agent in Charge at Warehouse 13.  A former cryptographer and codebreaker for the NSA, he has spent over 30 years at the Warehouse and is very knowledgeable about artifacts, both in the Warehouse and out in the world. He becomes a surrogate father to Claudia.
Genelle Williams as Leena (seasons 1–4; guest season 5), the proprietor of the bed and breakfast in nearby Univille, where the team lives. She can read a person's aura.
Simon Reynolds as Daniel Dickinson (season 1; guest season 2), Pete and Myka's former boss in Washington, D.C.
Allison Scagliotti as Claudia Donovan (seasons 2–5; recurring season 1) is described as a "young, hip, brilliant techno-wiz" who earns a job at Warehouse 13 after discovering too many of its secrets. She can hack into almost any computer network and occasionally modifies artifacts to suit her needs.
Aaron Ashmore as Steve Jinks (seasons 4–5; recurring season 3)  was an ATF agent before being recruited to Warehouse 13 for his ability to know if people are lying. In "Emily Lake" he is killed by Marcus Diamond (Sasha Roiz) on orders of Walter Sykes (Anthony Michael Hall). In season 4, he is resurrected by Claudia using the metronome. Ashmore was promoted to series regular beginning with the episode "Personal Effects".
Warehouse 13