Mackenzie was born in Brahan Castle in about 1621.
Her parents were Colin Mackenzie, the first earl of Seaforth, Viscount Fortrose, and Lord Mackenzie of Kintail, and Margaret, the daughter of Alexander Seton, 1st Earl of Dunfermline, Lord Chancellor of Scotland.
She had several siblings, all of whom died young except for an elder sister, Jean (died 1648).
Her parents died whilst Anna was a child.

After her father's death, in 1633, she resided at Leslie House, the seat of her cousin, Lord Rothes.
There she was married in April 1640, against the wish of her uncle, then the head of the family, to another cousin, Alexander Lindsay, master of Balcarres, who became Lord Balcarres in the following year.
She worked throughout her life to keep together the estates of Balcarres despite the tumultuous times in which she lived and her family's support of the Jacobite cause.

In 1647, her husband became responsible for Edinburgh Castle and in 1651, Charles II became the King of Scots and he promoted her husband to be the Earl of Balcarres.
On 22 February 1651, the king paid the couple a visit shortly before the birth of her first child, to whom he became godfather.
On the invasion after Worcester, she went with her husband to the Scottish Highlands, where he had command of the royalists.
To pay for the debts incurred by Balcarres in the royal cause, she sold her jewels and other valuables, and many years of her subsequent life were spent in redeeming the ruin in which the Balcarres family had been involved.

Their support for the king resulted in their estates being seized.
Her husband tried to raise a rebellion in Scotland, but in 1654 they were both summoned to France to assist the king.
Leaving her own children in Scotland, Anna was chosen to be the governess of the future William III of England in the Hague in 1657.
Between Anna, her husband, John Maitland, 1st Duke of Lauderdale, Kincardine, and Robert Moray there existed a close friendship, as well as family connection.
After her husband's death at the Hague on 30 August 1659, her young son, Charles (1650–1662) became the Earl.

The countess returned immediately to Fifeshire, but shortly went on to France, where, being attached to the Presbyterian church, she was instrumental in securing the support of the French Protestant ministers for the king in 1660.
At the Restoration, a pension was settled upon her by Charles, who often expressed for her a deep admiration, but it was some years before it was paid.
During the interval, she and her children suffered great privations.
She remained in England until May 1662, and there became acquainted with Richard Baxter, who declared that "her great wisdom, modesty, piety, and sincerity made her accounted the saint at the court".
The conversion of her eldest daughter and the daughter's subsequent death in a nunnery were a great blow to Anna.
In 1662, she returned to Scotland, when from poverty and anxiety she became ill.
The King agreed to pay Anna and the elder of her two sons £1000 a year in recognition of the assistance he had received from their family.
The money was not a complete gift as they had to return the governorship of Edinburgh Castle.
Her son Charles died in October 1662, whereupon Colin succeeded as 3rd Earl of Balcarres.
In 1664, her financial condition improved by the payment of the promised pension, for which she had petitioned in November 1663, but the friendship with Lauderdale appears to have been broken off.
The next few years were spent in trying to pay off the debts upon the Balcarres estates, and in 1669, her son's rights on the Seaforth estates were given up by her for the sum of 80,000 marks.
Mackenzie was born in Brahan Castle in about 1621. Her parents were Colin Mackenzie, the first earl of Seaforth, Viscount Fortrose, and Lord Mackenzie of Kintail, and Margaret, the daughter of Alexander Seton, 1st Earl of Dunfermline, Lord Chancellor of Scotland. She had several siblings, all of whom died young except for an elder sister, Jean (died 1648). Her parents died whilst Anna was a child.
After her father's death, in 1633, she resided at Leslie House, the seat of her cousin, Lord Rothes. There she was married in April 1640, against the wish of her uncle, then the head of the family, to another cousin, Alexander Lindsay, master of Balcarres, who became Lord Balcarres in the following year. She worked throughout her life to keep together the estates of Balcarres despite the tumultuous times in which she lived and her family's support of the Jacobite cause.
In 1647, her husband became responsible for Edinburgh Castle and in 1651, Charles II became the King of Scots and he promoted her husband to be the Earl of Balcarres. On 22 February 1651, the king paid the couple a visit shortly before the birth of her first child, to whom he became godfather. On the invasion after Worcester, she went with her husband to the Scottish Highlands, where he had command of the royalists. To pay for the debts incurred by Balcarres in the royal cause, she sold her jewels and other valuables, and many years of her subsequent life were spent in redeeming the ruin in which the Balcarres family had been involved.
Their support for the king resulted in their estates being seized. Her husband tried to raise a rebellion in Scotland, but in 1654 they were both summoned to France to assist the king. Leaving her own children in Scotland, Anna was chosen to be the governess of the future William III of England in the Hague in 1657. Between Anna, her husband, John Maitland, 1st Duke of Lauderdale, Kincardine, and Robert Moray there existed a close friendship, as well as family connection. After her husband's death at the Hague on 30 August 1659, her young son, Charles (1650–1662) became the Earl.
The countess returned immediately to Fifeshire, but shortly went on to France, where, being attached to the Presbyterian church, she was instrumental in securing the support of the French Protestant ministers for the king in 1660. At the Restoration, a pension was settled upon her by Charles, who often expressed for her a deep admiration, but it was some years before it was paid. During the interval, she and her children suffered great privations. She remained in England until May 1662, and there became acquainted with Richard Baxter, who declared that "her great wisdom, modesty, piety, and sincerity made her accounted the saint at the court". The conversion of her eldest daughter and the daughter's subsequent death in a nunnery were a great blow to Anna. In 1662, she returned to Scotland, when from poverty and anxiety she became ill. The King agreed to pay Anna and the elder of her two sons £1000 a year in recognition of the assistance he had received from their family. The money was not a complete gift as they had to return the governorship of Edinburgh Castle. Her son Charles died in October 1662, whereupon Colin succeeded as 3rd Earl of Balcarres. In 1664, her financial condition improved by the payment of the promised pension, for which she had petitioned in November 1663, but the friendship with Lauderdale appears to have been broken off. The next few years were spent in trying to pay off the debts upon the Balcarres estates, and in 1669, her son's rights on the Seaforth estates were given up by her for the sum of 80,000 marks.
Anna Mackenzie