Tsotsobe made his international debut for South Africa in a Twenty20 International against Australia at the Melbourne Cricket Ground on 11 January 2009.

On 30 January, he took 4/50 from nine overs in his ODI debut against Australia.
South Africa went on to win the match by 39 runs, and the ODI series by 4–1.

He made his Test debut in the first match against the West Indies in Trinidad in June 2010.

He then participated in the second Twenty20 International vs Zimbabwe in place of the injured Morné Morkel and after conceding two fours in his opening over he took the crucial wicket of Hamilton Masakadza.
He was a member of the South African squad for the 2011 World Cup, in which South Africa reached the quarter-finals.
Tsotsobe is said to have the ability to produce low economy rates and bowl deliveries between 120–135 km/h.

South Africa has decided not to include Tsotsobe into the test team to Australia in 2012–13 as they choose pace bowler Rory Kleinveldt instead.
Tsotsobe made his international debut for South Africa in a Twenty20 International against Australia at the Melbourne Cricket Ground on 11 January 2009.
On 30 January, he took 4/50 from nine overs in his ODI debut against Australia. South Africa went on to win the match by 39 runs, and the ODI series by 4–1.
He made his Test debut in the first match against the West Indies in Trinidad in June 2010.
He then participated in the second Twenty20 International vs Zimbabwe in place of the injured Morné Morkel and after conceding two fours in his opening over he took the crucial wicket of Hamilton Masakadza. He was a member of the South African squad for the 2011 World Cup, in which South Africa reached the quarter-finals. Tsotsobe is said to have the ability to produce low economy rates and bowl deliveries between 120–135 km/h.
South Africa has decided not to include Tsotsobe into the test team to Australia in 2012–13 as they choose pace bowler Rory Kleinveldt instead.
Lonwabo Tsotsobe