Aristotle (384–322 BC, ancient philosopher, lived in Chalcis the last year of his life (323–322 BC))
Giovanni Maria Angiolello from Vicenza, Italy, 15th century.

Yiannis Anastasopoulos (1931–present), author
Eva Asderaki Professional Tennis Umpire, first woman to umpire the US Open tennis final.

Sotiria Bellou (1921–1997), singer
Angelos Basinas (1976–present), professional footballer
Nikolaos Christodoulou, military officer
Mordehai Frizis (1893–1940), military officer
Dimitrios Katheniotis, military officer
Nikolaos Kalogeropoulos, PM of Greece
Konstantinos Kallias (1901–2004), politician
Orestis Makris (1898–1975), actor and tenor
Dimitris Mytaras (1934–2017), painter
Georgios Papanikolaou (1883–1962), physician, Pap smear test founder
Nikos Skalkottas (1901–1949), composer
Giannis Skarimpas (Agia Efthymia, 1893–1984), author
Aristotle (384–322 BC, ancient philosopher, lived in Chalcis the last year of his life (323–322 BC))
Giovanni Maria Angiolello from Vicenza, Italy, 15th century.
Yiannis Anastasopoulos (1931–present), author
Eva Asderaki Professional Tennis Umpire, first woman to umpire the US Open tennis final. 
Sotiria Bellou (1921–1997), singer
Angelos Basinas (1976–present), professional footballer
Nikolaos Christodoulou, military officer
Mordehai Frizis (1893–1940), military officer
Dimitrios Katheniotis, military officer
Nikolaos Kalogeropoulos, PM of Greece
Konstantinos Kallias (1901–2004), politician
Orestis Makris (1898–1975), actor and tenor
Dimitris Mytaras (1934–2017), painter
Georgios Papanikolaou (1883–1962), physician, Pap smear test founder
Nikos Skalkottas (1901–1949), composer
Giannis Skarimpas (Agia Efthymia, 1893–1984), author
Chalcis