The old headquarters building of the bank, designed by George W. Kelham, has an Ionic colonnade that is pure Beaux-Arts, while the upper building is in the new Moderne fashion of 1924.
The lobby with murals by Jules Guerin who created the palette for the 1915 Panama-Pacific International Exhibition.
In 1983 the bank relocated to larger and more modern facilities on 101 Market Street as the 400 Sansome Street location was sold to private developers who rented out the space.
Prominent law firm Orrick Herrington & Sutcliffe was headquartered in the building until 2002 when the firm moved out of the space.
The building continues to be owned by private developers and current tenants include the Bar Association of San Francisco.
 It is listed on the National Register of Historic Places (NRHP).

There is also a Federal Reserve Bank of San Francisco building in Los Angeles.
 The 1929 built building is also NRHP-listed.

From 1951 to 2008, the Seattle branch was headquartered at the Federal Reserve Bank Building in Downtown Seattle, which had been built in 1951 for the branch and is listed on the NRHP.
The old headquarters building of the bank, designed by George W. Kelham, has an Ionic colonnade that is pure Beaux-Arts, while the upper building is in the new Moderne fashion of 1924. The lobby with murals by Jules Guerin who created the palette for the 1915 Panama-Pacific International Exhibition. In 1983 the bank relocated to larger and more modern facilities on 101 Market Street as the 400 Sansome Street location was sold to private developers who rented out the space. Prominent law firm Orrick Herrington & Sutcliffe was headquartered in the building until 2002 when the firm moved out of the space. The building continues to be owned by private developers and current tenants include the Bar Association of San Francisco.  It is listed on the National Register of Historic Places (NRHP).
There is also a Federal Reserve Bank of San Francisco building in Los Angeles.  The 1929 built building is also NRHP-listed.
From 1951 to 2008, the Seattle branch was headquartered at the Federal Reserve Bank Building in Downtown Seattle, which had been built in 1951 for the branch and is listed on the NRHP.
Federal Reserve Bank of San Francisco