In November 2005, Zourabichvili set up the organization 'Salomé Zourabichvili’s Movement'.
In January 2006 she announced the establishment of a new political party Georgia's Way, criticizing the country's "de facto one-party system."
Although Zourabichvili enjoyed some degree of reputation in Georgia she was long unable to establish herself in the political field.
At the city council elections in Tbilisi on 5 October 2006, only 2.77% of the constituency voted for her party.
Six months before, an opinion poll conducted by the Georgian weekly Kviris Palitra suggested that she would garner 23.1% of the votes at presidential elections.
Since October 2007, her party was part of the United Opposition alliance which nominated Zourabichvili as a Prospective Prime Minister in case of their candidate Levan Gachechiladze's victory in the January 2008 presidential election.

As part of a 2009 campaign of the Georgian opposition to force President Mikheil Saakashvili to resign, Zourabichvili led a protest march together with three other prominent opposition figures – Nino Burjanadze, David Gamkrelidze and Eka Beselia – in Tbilisi on 26 March 2009.

On 12 November 2010, Zourabichvili announced her withdrawal from the leadership of Georgia's Way.
She was succeeded by Kakha Seturidze.
After a two-year leave from politics, she publicly endorsed Georgian Dream ahead of the 2013 presidential elections.
Shortly after, Georgia's Central Election Commission refused to register her as a presidential candidate due to her dual Georgian-French citizenship.

In the 2016 parliamentary elections Zourabichvili won a seat as an independent, representing the Mtatsminda region of Tbilisi.
In November 2005, Zourabichvili set up the organization 'Salomé Zourabichvili’s Movement'. In January 2006 she announced the establishment of a new political party Georgia's Way, criticizing the country's "de facto one-party system." Although Zourabichvili enjoyed some degree of reputation in Georgia she was long unable to establish herself in the political field. At the city council elections in Tbilisi on 5 October 2006, only 2.77% of the constituency voted for her party. Six months before, an opinion poll conducted by the Georgian weekly Kviris Palitra suggested that she would garner 23.1% of the votes at presidential elections. Since October 2007, her party was part of the United Opposition alliance which nominated Zourabichvili as a Prospective Prime Minister in case of their candidate Levan Gachechiladze's victory in the January 2008 presidential election.
As part of a 2009 campaign of the Georgian opposition to force President Mikheil Saakashvili to resign, Zourabichvili led a protest march together with three other prominent opposition figures – Nino Burjanadze, David Gamkrelidze and Eka Beselia – in Tbilisi on 26 March 2009.
On 12 November 2010, Zourabichvili announced her withdrawal from the leadership of Georgia's Way. She was succeeded by Kakha Seturidze. After a two-year leave from politics, she publicly endorsed Georgian Dream ahead of the 2013 presidential elections. Shortly after, Georgia's Central Election Commission refused to register her as a presidential candidate due to her dual Georgian-French citizenship.
In the 2016 parliamentary elections Zourabichvili won a seat as an independent, representing the Mtatsminda region of Tbilisi.
Salome Zourabichvili