Since her husband died while she was pregnant, her son William immediately became Prince of Orange upon his birth six weeks later.
Marie Louise served as regent for her son from 1711 until he reached his majority in 1731.
This regency was granted despite her inexperience with the affairs of her adopted country.
Although she did not have any experience, Marie Louise successfully withstood a series of natural disasters, which included a sequence of bad harvests and severe winters from 1712 to 1716.
At the time of her marriage, Marie Louise quickly earned the affection of the Dutch population.
She was known as a woman of intelligence and sensitivity, and was often fondly referred to as Marijke Meu.
She also dealt with a major problem concerning shipworms – parasites that upon arriving on ships from the Far East, proceeded to devour wooden sections of the vital, protective dykes.
These damages threatened to collapse the entire dyke system, which would have destroyed vast amounts of land used for farming in the Dutch province of Friesland.
The money needed to prevent such an occurrence from happening was hard to raise however; tax obligations to the Hague from this province were seldom realistically reviewed.
In order to end the looming starvation, Marie Louise traveled to the Hague and pleaded in person before the States-General for help.
She apparently spoke so eloquently that she returned home with not only a remittance on taxation, but also with a sizable detachment of soldiers to help repair the dykes.

After a 1736 visit, Marie Louise maintained a correspondence, in "abominable French," with religious and social reformer Count Nikolaus Ludwig of Zinzendorf and Pottendorf.
A deeply religious woman, she provided sanctuary to persecuted Protestants fleeing the Catholic Habsburgs.
Despite her son's objections, Marie Louise allowed a group of Moravians to settle in the barony of IJsselstein, of which she was baroness.
Since her husband died while she was pregnant, her son William immediately became Prince of Orange upon his birth six weeks later. Marie Louise served as regent for her son from 1711 until he reached his majority in 1731. This regency was granted despite her inexperience with the affairs of her adopted country. Although she did not have any experience, Marie Louise successfully withstood a series of natural disasters, which included a sequence of bad harvests and severe winters from 1712 to 1716. At the time of her marriage, Marie Louise quickly earned the affection of the Dutch population. She was known as a woman of intelligence and sensitivity, and was often fondly referred to as Marijke Meu. She also dealt with a major problem concerning shipworms – parasites that upon arriving on ships from the Far East, proceeded to devour wooden sections of the vital, protective dykes. These damages threatened to collapse the entire dyke system, which would have destroyed vast amounts of land used for farming in the Dutch province of Friesland. The money needed to prevent such an occurrence from happening was hard to raise however; tax obligations to the Hague from this province were seldom realistically reviewed. In order to end the looming starvation, Marie Louise traveled to the Hague and pleaded in person before the States-General for help. She apparently spoke so eloquently that she returned home with not only a remittance on taxation, but also with a sizable detachment of soldiers to help repair the dykes.
After a 1736 visit, Marie Louise maintained a correspondence, in "abominable French," with religious and social reformer Count Nikolaus Ludwig of Zinzendorf and Pottendorf. A deeply religious woman, she provided sanctuary to persecuted Protestants fleeing the Catholic Habsburgs. Despite her son's objections, Marie Louise allowed a group of Moravians to settle in the barony of IJsselstein, of which she was baroness.
Landgravine Marie Louise of Hesse-Kassel