In April 2007, Timberlake was seen entering a London studio with Madonna, thus confirming rumors that he was collaborating with her.
A song "4 Minutes", was first played by Timbaland at Philadelphia's Jingle Ball on December 17, 2007.
When released on March 17, 2008, "4 Minutes" was revealed to be a duet between Timberlake and Madonna, with backing vocals by Timbaland.
It was lead single from Madonna's eleventh studio album Hard Candy, which featured four other songwriting collaborations with Timberlake.
The single was an international hit, and topped the charts in Australia, Belgium, Canada, Denmark, Finland, Germany, Italy, Netherlands, Norway, Sweden, Switzerland and the United Kingdom, and reached the Top 5 in Austria, France, Ireland, Japan, New Zealand and the United States.
Timberlake also appears in the music video, which was directed by Jonas & François.
On March 30, 2008, Timberlake performed the song at Madonna's Hard Candy Promo Show at Roseland Ballroom in New York City.
On November 6, 2008, Timberlake performed the song with Madonna on the Los Angeles stop of her Sticky & Sweet Tour.

Around June 2007 Timberlake co-wrote, produced and provided vocals for the songs "Nite Runner" and "Falling Down" for Duran Duran's album Red Carpet Massacre, released on November 13, 2007. "
Falling Down" had been released as a single in the UK on the previous day.

Also in 2007, Timberlake made an appearance on 50 Cent's third album, Curtis.
Timberlake, along with Timbaland, is featured on a track called "Ayo Technology", which was the album's fourth single.
Also, another possible collaboration was to occur with Lil Wayne for his album Tha Carter III with Nelly Furtado and Timbaland.

With the wrapping up of the FutureSex/LoveSounds tour of Australasia and the Middle East in November 2007, Timberlake resumed his movie career.
Projects underway early in 2008 were starring roles in Mike Myers' comedy The Love Guru (released June 20, 2008) and Mike Meredith's drama The Open Road (released August 28, 2009).
In March 2008 it was announced that he was be an executive producer in an American adaptation of the hit Peruvian comedy My Problem with Women for NBC.

On November 20, 2008, TV Guide reported that Timberlake's next single, "Follow My Lead", which also featured vocals by Timberlake's protégée, former YouTube star Esmee Denters, would be available for exclusive download through MySpace.
All proceeds would go to Shriners Hospitals for Children, a charity dedicated to improving pediatric care for sick children.

In 2008, a collaboration between Timberlake and T.I., "Dead and Gone" featured on T.I.'s sixth studio album, Paper Trail, and was released as its fourth single late in 2009.
In November 2008, it was confirmed that Timberlake would make a guest appearance and produce some tracks on R&B/pop singer Ciara's upcoming album Fantasy Ride due out May 5, 2009.
Timberlake featured on Ciara's second single "Love Sex Magic", the video being shot on February 20, 2009.
The single became a worldwide hit, reaching the top ten in numerous countries and peaking at number one in several countries including Taiwan, India, and Turkey.
The single is now nominated for Best Pop Collaboration with Vocals at the 52nd Grammy Awards.

Timberlake and his production team The Y's, along with Mike Elizondo, produced and co-wrote the song "Don't Let Me Down" for Leona Lewis's second studio album, Echo, released (in the US) on November 17, 2009.

Timberlake also co-wrote and performed on "Carry Out," the third single from Timbaland's album Shock Value II, released on December 1, 2009.
In April 2007, Timberlake was seen entering a London studio with Madonna, thus confirming rumors that he was collaborating with her. A song "4 Minutes", was first played by Timbaland at Philadelphia's Jingle Ball on December 17, 2007. When released on March 17, 2008, "4 Minutes" was revealed to be a duet between Timberlake and Madonna, with backing vocals by Timbaland. It was lead single from Madonna's eleventh studio album Hard Candy, which featured four other songwriting collaborations with Timberlake. The single was an international hit, and topped the charts in Australia, Belgium, Canada, Denmark, Finland, Germany, Italy, Netherlands, Norway, Sweden, Switzerland and the United Kingdom, and reached the Top 5 in Austria, France, Ireland, Japan, New Zealand and the United States. Timberlake also appears in the music video, which was directed by Jonas & François. On March 30, 2008, Timberlake performed the song at Madonna's Hard Candy Promo Show at Roseland Ballroom in New York City. On November 6, 2008, Timberlake performed the song with Madonna on the Los Angeles stop of her Sticky & Sweet Tour.
Around June 2007 Timberlake co-wrote, produced and provided vocals for the songs "Nite Runner" and "Falling Down" for Duran Duran's album Red Carpet Massacre, released on November 13, 2007. "Falling Down" had been released as a single in the UK on the previous day.
Also in 2007, Timberlake made an appearance on 50 Cent's third album, Curtis. Timberlake, along with Timbaland, is featured on a track called "Ayo Technology", which was the album's fourth single. Also, another possible collaboration was to occur with Lil Wayne for his album Tha Carter III with Nelly Furtado and Timbaland.
With the wrapping up of the FutureSex/LoveSounds tour of Australasia and the Middle East in November 2007, Timberlake resumed his movie career. Projects underway early in 2008 were starring roles in Mike Myers' comedy The Love Guru (released June 20, 2008) and Mike Meredith's drama The Open Road (released August 28, 2009). In March 2008 it was announced that he was be an executive producer in an American adaptation of the hit Peruvian comedy My Problem with Women for NBC.
On November 20, 2008, TV Guide reported that Timberlake's next single, "Follow My Lead", which also featured vocals by Timberlake's protégée, former YouTube star Esmee Denters, would be available for exclusive download through MySpace. All proceeds would go to Shriners Hospitals for Children, a charity dedicated to improving pediatric care for sick children.
In 2008, a collaboration between Timberlake and T.I., "Dead and Gone" featured on T.I.'s sixth studio album, Paper Trail, and was released as its fourth single late in 2009. In November 2008, it was confirmed that Timberlake would make a guest appearance and produce some tracks on R&B/pop singer Ciara's upcoming album Fantasy Ride due out May 5, 2009. Timberlake featured on Ciara's second single "Love Sex Magic", the video being shot on February 20, 2009. The single became a worldwide hit, reaching the top ten in numerous countries and peaking at number one in several countries including Taiwan, India, and Turkey. The single is now nominated for Best Pop Collaboration with Vocals at the 52nd Grammy Awards.
Timberlake and his production team The Y's, along with Mike Elizondo, produced and co-wrote the song "Don't Let Me Down" for Leona Lewis's second studio album, Echo, released (in the US) on November 17, 2009.
Timberlake also co-wrote and performed on "Carry Out," the third single from Timbaland's album Shock Value II, released on December 1, 2009.
Justin Timberlake