Eddy was badly affected by four deaths in the 1840s.
She regarded her brother Albert as a teacher and mentor, but he died in 1841.
In 1844, her first husband George Washington Glover (a friend of her brother Samuel) died after six months of marriage.
They had married in December 1843 and set up home in Charleston, South Carolina, where Glover had business, but he died of yellow fever in June 1844 while living in Wilmington, North Carolina.
Eddy was with him in Wilmington, six months pregnant.
She had to make her way back to New Hampshire, 1,400 miles by train and steamboat, where her only child George Washington II was born on 12 September in her father's home.

Her husband's death, the journey back, and the birth left her physically and mentally exhausted, and she ended up bedridden for months.
She tried to earn a living by writing articles for the New Hampshire Patriot and various Odd Fellows and Masonic publications.
She also worked as a substitute teacher in the New Hampshire Conference Seminary, and ran her own kindergarten for a few months in 1846, apparently refusing to use corporal punishment.

Then her mother died in November 1849.
Eddy wrote to one of her brothers: "What is left of earth to me!"
Her mother's death was followed three weeks later by the death of her fiancé, lawyer John Bartlett.
In 1850, Eddy wrote, her son was sent away to be looked after by the family's nurse; he was four years old by then.
Sources differ as to whether Eddy could have prevented this.
It was difficult for a woman in her circumstances to earn money and, according to the legal doctrine of coverture, women in the United States during this period could not be their own children's guardians.
When their husbands died, they were left in a legally vulnerable position.

Mark Baker remarried in 1850; his second wife Elizabeth Patterson Duncan (d. 6 June 1875) had been widowed twice, and had some property and income from her second marriage.
Baker apparently made clear to Eddy that her son would not be welcome in the new marital home.
She wrote:
A few months before my father's second marriage ... my little son, about four years of age, was sent away from me, and put under the care of our family nurse, who had married, and resided in the northern part of New Hampshire.
I had no training for self-support, and my home I regarded as very precious.
The night before my child was taken from me, I knelt by his side throughout the dark hours, hoping for a vision of relief from this trial.

George was sent to stay with various relatives, and Eddy decided to live with her sister Abigail.
Abigail apparently also declined to take George, then six years old.
Eddy married again in 1853.
Her second husband, Daniel Patterson, was a dentist and apparently said that he would become George's legal guardian; but he appears not to have gone ahead with this, and Eddy lost contact with her son when the family that looked after him, the Cheneys, moved to Minnesota, and then her son several years later enlisted in the Union army during the Civil War.
She did not see him again until he was in his thirties:
My dominant thought in marrying again was to get back my child, but after our marriage his stepfather was not willing he should have a home with me.
A plot was consummated for keeping us apart.
The family to whose care he was committed very soon removed to what was then regarded as the Far West.

After his removal a letter was read to my little son, informing him that his mother was dead and buried.
Without my knowledge a guardian was appointed him, and I was then informed that my son was lost.
Every means within my power was employed to find him, but without success.
We never met again until he had reached the age of thirty-four, had a wife and two children, and by a strange providence had learned that his mother still lived, and came to see me in Massachusetts.
Eddy was badly affected by four deaths in the 1840s. She regarded her brother Albert as a teacher and mentor, but he died in 1841. In 1844, her first husband George Washington Glover (a friend of her brother Samuel) died after six months of marriage. They had married in December 1843 and set up home in Charleston, South Carolina, where Glover had business, but he died of yellow fever in June 1844 while living in Wilmington, North Carolina. Eddy was with him in Wilmington, six months pregnant. She had to make her way back to New Hampshire, 1,400 miles by train and steamboat, where her only child George Washington II was born on 12 September in her father's home.
Her husband's death, the journey back, and the birth left her physically and mentally exhausted, and she ended up bedridden for months. She tried to earn a living by writing articles for the New Hampshire Patriot and various Odd Fellows and Masonic publications. She also worked as a substitute teacher in the New Hampshire Conference Seminary, and ran her own kindergarten for a few months in 1846, apparently refusing to use corporal punishment.
Then her mother died in November 1849. Eddy wrote to one of her brothers: "What is left of earth to me!" Her mother's death was followed three weeks later by the death of her fiancé, lawyer John Bartlett. In 1850, Eddy wrote, her son was sent away to be looked after by the family's nurse; he was four years old by then. Sources differ as to whether Eddy could have prevented this. It was difficult for a woman in her circumstances to earn money and, according to the legal doctrine of coverture, women in the United States during this period could not be their own children's guardians. When their husbands died, they were left in a legally vulnerable position.
Mark Baker remarried in 1850; his second wife Elizabeth Patterson Duncan (d. 6 June 1875) had been widowed twice, and had some property and income from her second marriage. Baker apparently made clear to Eddy that her son would not be welcome in the new marital home. She wrote:
A few months before my father's second marriage ... my little son, about four years of age, was sent away from me, and put under the care of our family nurse, who had married, and resided in the northern part of New Hampshire. I had no training for self-support, and my home I regarded as very precious. The night before my child was taken from me, I knelt by his side throughout the dark hours, hoping for a vision of relief from this trial.
George was sent to stay with various relatives, and Eddy decided to live with her sister Abigail. Abigail apparently also declined to take George, then six years old. Eddy married again in 1853. Her second husband, Daniel Patterson, was a dentist and apparently said that he would become George's legal guardian; but he appears not to have gone ahead with this, and Eddy lost contact with her son when the family that looked after him, the Cheneys, moved to Minnesota, and then her son several years later enlisted in the Union army during the Civil War. She did not see him again until he was in his thirties:
My dominant thought in marrying again was to get back my child, but after our marriage his stepfather was not willing he should have a home with me. A plot was consummated for keeping us apart. The family to whose care he was committed very soon removed to what was then regarded as the Far West.
After his removal a letter was read to my little son, informing him that his mother was dead and buried. Without my knowledge a guardian was appointed him, and I was then informed that my son was lost. Every means within my power was employed to find him, but without success. We never met again until he had reached the age of thirty-four, had a wife and two children, and by a strange providence had learned that his mother still lived, and came to see me in Massachusetts.
Mary Baker Eddy