On July 14, 2010 Escobar was traded by the Braves to the Toronto Blue Jays with Jo-Jo Reyes for shortstop Alex González and two minor league prospects: left-handed pitcher Tim Collins and shortstop Tyler Pastornicky.

Days later Escobar would hit the Jays' first Grand Slam of the season in Baltimore in just his third game with the team.
Escobar hit his second home run for the Blue Jays in his fourth game with the club, against Kansas City on July 19, 2010.

On September 6, 2010, after returning from an injury, Escobar hit his fourth home run of the season in a 7–2 win over the Texas Rangers, after having played 75 games without a home run with the Braves.

Escobar was an opening day starter at shortstop on April 1 for the Jays.
On April 5, Escobar hit a 2-run walk-off home run against the Oakland Athletics, his second career walk-off home run.
On April 6, 2011, Escobar left the game after sliding head first into third.
He hit his head on third baseman Andy LaRoche's knee.
On May 23, 2011, Escobar batted in the clean-up position (4th) for the first time in his career.
He went 1-for-3.

On June 19, 2011, the Blue Jays announced that Escobar had been signed to a two-year contract extension worth $10 million.
The deal also included club options for 2014 and 2015, each worth $5 million.

In a game against the New York Yankees on August 29, 2012, Escobar tied career highs in hits (with 4) and RBI (with 5) in an 8–5 win.
On July 14, 2010 Escobar was traded by the Braves to the Toronto Blue Jays with Jo-Jo Reyes for shortstop Alex González and two minor league prospects: left-handed pitcher Tim Collins and shortstop Tyler Pastornicky.
Days later Escobar would hit the Jays' first Grand Slam of the season in Baltimore in just his third game with the team. Escobar hit his second home run for the Blue Jays in his fourth game with the club, against Kansas City on July 19, 2010.
On September 6, 2010, after returning from an injury, Escobar hit his fourth home run of the season in a 7–2 win over the Texas Rangers, after having played 75 games without a home run with the Braves.
Escobar was an opening day starter at shortstop on April 1 for the Jays. On April 5, Escobar hit a 2-run walk-off home run against the Oakland Athletics, his second career walk-off home run. On April 6, 2011, Escobar left the game after sliding head first into third. He hit his head on third baseman Andy LaRoche's knee. On May 23, 2011, Escobar batted in the clean-up position (4th) for the first time in his career. He went 1-for-3.
On June 19, 2011, the Blue Jays announced that Escobar had been signed to a two-year contract extension worth $10 million. The deal also included club options for 2014 and 2015, each worth $5 million.
In a game against the New York Yankees on August 29, 2012, Escobar tied career highs in hits (with 4) and RBI (with 5) in an 8–5 win.
Yunel Escobar