Gibbs got her first acting job in the early 1970s, in the blaxploitation films Sweet Jesus, Preacher Man and  Black Belt Jones.
In 1975 she was cast as Florence Johnston, the family's maid, in the CBS comedy series The Jeffersons.
For her performance on the series, Gibbs was nominated for a Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series five times, and once for a Golden Globe Award for Best Supporting Actress – Series, Miniseries or Television Film.
In 1981 she starred in the short-lived spin-off of The Jeffersons, titled Checking In.
Gibbs responded in a 2015 interview on Broadway Showbiz, when asked if she'd based any of her characters on real-life people:
"Yes, Florence was like my aunt and grandmother so I lived it.
She came easy to me so I'm like Florence in giving smart answers, but I was also shy so I wouldn't have dared to say some of the things Florence said.
I prefer to do whatever I can do at the moment.
Whoever's hiring me at the moment...that's what I'm supposed to do.
My favorite is drama.
I'm doing that now (on Scandal), but also still doing comedy on Hot in Cleveland."
In 1985, when The Jeffersons was cancelled after 11 seasons, Gibbs was the lead actress in the NBC sitcom, 227.
227 was adapted from a play directed by Cambridge Players' then-president Ed Cambridge and was presented to NBC by Cambridge, at Gibbs' Crossroads Theater in L.A. He served as artistic director.
The series aired until 1990, producing 116 episodes.
Two decades later, Gibbs teamed again with former 227 co-star Jackée Harry in The First Family, where Gibbs had a recurring role as Harry's on-screen mother Grandma Eddy.
Then, she again worked with Harry in the independent film Forbidden Woman.

Gibbs had a number of supporting film roles, and guest starred on The Fresh Prince of Bel-Air, Touched by an Angel (with Della Reese), Judging Amy, ER, and Southland.
From 1998 to 2002 she had a recurring role on The Hughleys.
In 2012, Gibbs appeared in the Tyler Perry film Madea's Witness Protection, and in 2014 she starred in the independent film, Grantham & Rose.

In 2015, Gibbs made two appearances in the Shonda Rhimes' drama series, Scandal.
She later guest starred on Hot in Cleveland, American Horror Story: Hotel and This Is Us.
In 2018, she was cast in a recurring role on the ABC drama series Station 19.
Gibbs also has had starring roles in two television pilots: Old Soul alongside Ellen Burstyn and Rita Moreno for NBC in 2014, and ABC's Jalen Vs.
Everybody in 2017.
In film, she co-starred in Lemon and Please Stand By.

Gibbs owned a jazz club in South Central L.A. called Marla's Memory Lane Jazz and Supper Club from 1981 to 1999.
As a singer, she released a number of albums.

In 2019, Gibbs reprised her role as Florence on Live in Front of a Studio Audience: Norman Lear's All in the Family and The Jeffersons, less than a month shy of her 88th birthday.
Gibbs got her first acting job in the early 1970s, in the blaxploitation films Sweet Jesus, Preacher Man and  Black Belt Jones. In 1975 she was cast as Florence Johnston, the family's maid, in the CBS comedy series The Jeffersons. For her performance on the series, Gibbs was nominated for a Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series five times, and once for a Golden Globe Award for Best Supporting Actress – Series, Miniseries or Television Film. In 1981 she starred in the short-lived spin-off of The Jeffersons, titled Checking In. Gibbs responded in a 2015 interview on Broadway Showbiz, when asked if she'd based any of her characters on real-life people:
"Yes, Florence was like my aunt and grandmother so I lived it. She came easy to me so I'm like Florence in giving smart answers, but I was also shy so I wouldn't have dared to say some of the things Florence said. I prefer to do whatever I can do at the moment. Whoever's hiring me at the moment...that's what I'm supposed to do. My favorite is drama. I'm doing that now (on Scandal), but also still doing comedy on Hot in Cleveland." In 1985, when The Jeffersons was cancelled after 11 seasons, Gibbs was the lead actress in the NBC sitcom, 227. 227 was adapted from a play directed by Cambridge Players' then-president Ed Cambridge and was presented to NBC by Cambridge, at Gibbs' Crossroads Theater in L.A. He served as artistic director. The series aired until 1990, producing 116 episodes. Two decades later, Gibbs teamed again with former 227 co-star Jackée Harry in The First Family, where Gibbs had a recurring role as Harry's on-screen mother Grandma Eddy. Then, she again worked with Harry in the independent film Forbidden Woman.
Gibbs had a number of supporting film roles, and guest starred on The Fresh Prince of Bel-Air, Touched by an Angel (with Della Reese), Judging Amy, ER, and Southland. From 1998 to 2002 she had a recurring role on The Hughleys. In 2012, Gibbs appeared in the Tyler Perry film Madea's Witness Protection, and in 2014 she starred in the independent film, Grantham & Rose.
In 2015, Gibbs made two appearances in the Shonda Rhimes' drama series, Scandal. She later guest starred on Hot in Cleveland, American Horror Story: Hotel and This Is Us. In 2018, she was cast in a recurring role on the ABC drama series Station 19. Gibbs also has had starring roles in two television pilots: Old Soul alongside Ellen Burstyn and Rita Moreno for NBC in 2014, and ABC's Jalen Vs. Everybody in 2017. In film, she co-starred in Lemon and Please Stand By.
Gibbs owned a jazz club in South Central L.A. called Marla's Memory Lane Jazz and Supper Club from 1981 to 1999. As a singer, she released a number of albums.
In 2019, Gibbs reprised her role as Florence on Live in Front of a Studio Audience: Norman Lear's All in the Family and The Jeffersons, less than a month shy of her 88th birthday.
Marla Gibbs