Colonel Ambrosio José Gonzales (1818–1893) – Gonzales, a native Cuban, settled in South Carolina.
He was volunteering during the bombardment of Fort Sumter and became an inspector of coastal defences.
In 1862 he was assigned as Chief of Artillery to the Department of South Carolina, Georgia and Florida.
In 1864 he served as artillery commander at the Battle of Honey Hill during Sherman's March to the Sea.
President Jefferson Davis declined promotion requests for the rank of Brigadier General six times.
It is believed that neither Gonzales's early experience with Cuban filibusters, without success, nor his contentious relationships with Confederate officers in Richmond were aiding him; but most likely Davis' dislike for P. G. T. Beauregard, who was a schoolmate of Gonzalez and the proponent of several of the requests, didn't help either.

Colonel Leonidas M. Martin (1824–1904) – Martin organized and was a major in the 10th Texas Cavalry.
Promoted to Colonel was placed in charge of the 5th Texas Partisan Rangers under the command of Colonel Thomas C. Bass.
Martin participated in the Battle of Honey Springs, the largest battle fought in Indian Territory, fought on July 17, 1863.
The Union Forces were victorious and a result of the Confederate defeat in this battle was that the Confederates were always short on supplies in the Indian Territory forcing the Texas Cavalry to abandon the territory.

Colonel Santos Benavides (1823–1891) – Benavides commanded the 33rd Texas Cavalry Regiment.
He was the highest ranking Tejano in the Confederate Army.
On March 19, 1864, he defended Laredo against the Union's First Texas Cavalry, whose commander was Colonel Edmund J. Davis, a Florida native who had previously offered Benavides a Union generalship, and defeated the Union forces.
Probably his greatest contribution to the Confederacy was securing passage of Confederate cotton to Matamoros, Tamaulipas, Mexico, in 1863.
On March 18, 1864, Major Alfred Holt led a force of about two hundred men from the command of Col.
Davis near Brownsville, Texas, to destroy five thousand bales of cotton stacked at the San Agustín Plaza.
Colonel Santos Benavides commanded forty-two men and repelled three Union attacks at the Zacate Creek in what is known as the Battle of Laredo.

Lieutenant Colonel Paul Francis de Gournay (1828–1904) – De Gournay was a Cuban who fought for independence from Spain and afterwards settled in Louisiana.
In 1861 he equipped an artillery battery at his own expense and led it during the Peninsula Campaign in Virginia.
Later he became the commander of the 12th Battalion, Louisiana Heavy Artillery.
He served during the Siege of Port Hudson and with its surrender became a prisoner for the rest of the war.

Major David Camden DeLeón (1816–1872) – DeLeón a.k.a. "
The Fighting Doctor", came from a Sephardic Jewish family.
He was the first Hispanic to graduate from an Ivy League School (University of Pennsylvania – 1836).
In 1864, he became the first Surgeon General of the Confederate States.
The President of the Confederate States Jefferson Davis, assigned him the task of organizing the medical department of the Confederate Army.

Captain Michael Philip Usina (1840–1903) – was a member of the Confederate States Navy.
He was born in St. Augustine, Florida, to Spanish parents.
As captain of several blockade runners, Usina managed to avoid capture on his many successful missions.
Usina fought in Co. B in the 8th Georgia Infantry of the Confederate Army before being transferred to the Navy.
He was wounded and captured in the Battle of Manassas, but managed to escape and reach the Southern lines.
Colonel Ambrosio José Gonzales (1818–1893) – Gonzales, a native Cuban, settled in South Carolina. He was volunteering during the bombardment of Fort Sumter and became an inspector of coastal defences. In 1862 he was assigned as Chief of Artillery to the Department of South Carolina, Georgia and Florida. In 1864 he served as artillery commander at the Battle of Honey Hill during Sherman's March to the Sea. President Jefferson Davis declined promotion requests for the rank of Brigadier General six times. It is believed that neither Gonzales's early experience with Cuban filibusters, without success, nor his contentious relationships with Confederate officers in Richmond were aiding him; but most likely Davis' dislike for P. G. T. Beauregard, who was a schoolmate of Gonzalez and the proponent of several of the requests, didn't help either.
Colonel Leonidas M. Martin (1824–1904) – Martin organized and was a major in the 10th Texas Cavalry. Promoted to Colonel was placed in charge of the 5th Texas Partisan Rangers under the command of Colonel Thomas C. Bass. Martin participated in the Battle of Honey Springs, the largest battle fought in Indian Territory, fought on July 17, 1863. The Union Forces were victorious and a result of the Confederate defeat in this battle was that the Confederates were always short on supplies in the Indian Territory forcing the Texas Cavalry to abandon the territory.
Colonel Santos Benavides (1823–1891) – Benavides commanded the 33rd Texas Cavalry Regiment. He was the highest ranking Tejano in the Confederate Army. On March 19, 1864, he defended Laredo against the Union's First Texas Cavalry, whose commander was Colonel Edmund J. Davis, a Florida native who had previously offered Benavides a Union generalship, and defeated the Union forces. Probably his greatest contribution to the Confederacy was securing passage of Confederate cotton to Matamoros, Tamaulipas, Mexico, in 1863. On March 18, 1864, Major Alfred Holt led a force of about two hundred men from the command of Col. Davis near Brownsville, Texas, to destroy five thousand bales of cotton stacked at the San Agustín Plaza. Colonel Santos Benavides commanded forty-two men and repelled three Union attacks at the Zacate Creek in what is known as the Battle of Laredo.
Lieutenant Colonel Paul Francis de Gournay (1828–1904) – De Gournay was a Cuban who fought for independence from Spain and afterwards settled in Louisiana. In 1861 he equipped an artillery battery at his own expense and led it during the Peninsula Campaign in Virginia. Later he became the commander of the 12th Battalion, Louisiana Heavy Artillery. He served during the Siege of Port Hudson and with its surrender became a prisoner for the rest of the war.
Major David Camden DeLeón (1816–1872) – DeLeón a.k.a. "The Fighting Doctor", came from a Sephardic Jewish family. He was the first Hispanic to graduate from an Ivy League School (University of Pennsylvania – 1836). In 1864, he became the first Surgeon General of the Confederate States. The President of the Confederate States Jefferson Davis, assigned him the task of organizing the medical department of the Confederate Army.
Captain Michael Philip Usina (1840–1903) – was a member of the Confederate States Navy. He was born in St. Augustine, Florida, to Spanish parents. As captain of several blockade runners, Usina managed to avoid capture on his many successful missions. Usina fought in Co. B in the 8th Georgia Infantry of the Confederate Army before being transferred to the Navy. He was wounded and captured in the Battle of Manassas, but managed to escape and reach the Southern lines.
Hispanics in the American Civil War