The school is located at McMaster University's main campus in Hamilton, Ontario, housed within the Michael G. DeGroote Centre for Learning and Discovery, a building built in 2004 and the adjacent Health Sciences Centre.
The DeGroote facility is shared with the Centre for Function Genomics, Centre for Gene Therapeutics, Institute for Cancer and Stem Cell Biology Research, Robert E. Fitzhenry Vector Laboratory, Centre for Asthma and Allergy Research (Allergen) and North American Headquarters for West Nile studies, as well as the Bachelor of Health Sciences undergraduate program.

In 2016, the medical school opened the David Braley Health Sciences Centre, a 192,000 square foot building, to be used by the Family Medicine department, Hamilton Public Health and other various academic divisions of the medical school.

The medical school currently operates three campuses: the main Hamilton campus; the Waterloo Regional Campus located on the Health Sciences Campus of the University of Waterloo in downtown Kitchener, Ontario; and the Niagara Regional Campus located on the main campus of Brock University in St. Catharines, Ontario.
All three campuses offer the same curriculum and lead to the same degree, but differ in patient populations and teaching locations.

McMaster's teaching hospitals are divided into two major hospital groupings: Hamilton Health Sciences, recently ranked 2nd in Canada among research hospitals and St. Joseph's Healthcare Hamilton.

The school is also affiliated with the following Ontario hospitals, where students rotate and train during their clerkship:
St. Mary's General Hospital
Grand River Hospital
Joseph Brant Hospital
Brantford General Hospital
Cambridge Memorial Hospital
West Lincoln Memorial Hospital
Niagara Health System (Greater Niagara, Niagara-on-the Lake, Port Colborne Campuses)
Oakville-Trafalgar Memorial Hospital
Grey Bruce Health Services
Norfolk General Hospital
Brampton Civic Hospital
Markham Stouffville Hospital
Mackenzie Richmond Hill Hospital
Southlake Regional Health Centre
The school is located at McMaster University's main campus in Hamilton, Ontario, housed within the Michael G. DeGroote Centre for Learning and Discovery, a building built in 2004 and the adjacent Health Sciences Centre. The DeGroote facility is shared with the Centre for Function Genomics, Centre for Gene Therapeutics, Institute for Cancer and Stem Cell Biology Research, Robert E. Fitzhenry Vector Laboratory, Centre for Asthma and Allergy Research (Allergen) and North American Headquarters for West Nile studies, as well as the Bachelor of Health Sciences undergraduate program.
In 2016, the medical school opened the David Braley Health Sciences Centre, a 192,000 square foot building, to be used by the Family Medicine department, Hamilton Public Health and other various academic divisions of the medical school.
The medical school currently operates three campuses: the main Hamilton campus; the Waterloo Regional Campus located on the Health Sciences Campus of the University of Waterloo in downtown Kitchener, Ontario; and the Niagara Regional Campus located on the main campus of Brock University in St. Catharines, Ontario. All three campuses offer the same curriculum and lead to the same degree, but differ in patient populations and teaching locations.
McMaster's teaching hospitals are divided into two major hospital groupings: Hamilton Health Sciences, recently ranked 2nd in Canada among research hospitals and St. Joseph's Healthcare Hamilton.
The school is also affiliated with the following Ontario hospitals, where students rotate and train during their clerkship:
St. Mary's General Hospital
Grand River Hospital
Joseph Brant Hospital
Brantford General Hospital
Cambridge Memorial Hospital
West Lincoln Memorial Hospital
Niagara Health System (Greater Niagara, Niagara-on-the Lake, Port Colborne Campuses)
Oakville-Trafalgar Memorial Hospital
Grey Bruce Health Services
Norfolk General Hospital
Brampton Civic Hospital
Markham Stouffville Hospital
Mackenzie Richmond Hill Hospital
Southlake Regional Health Centre
McMaster University Medical School