Vesoul is located in the easter part of France, about 100 kilometers away from the Germany and the Switzerland's border and between the Jura and the Vosges's mountain ranges.
Vesoul is also situated in the center of the Haute-Saône, which is in the nord of Bourgogne-Franche-Comté.
Inside of this region, Vesoul is included in the Pays de Vesoul et du Val de Saône, a geographical region composing of the Vesoul's area and the northern part of the river Saône.

By the road, Vesoul is 32 kilometres (20 mi) from Luxeuil-les-Bains, 30 kilometres (19 mi) from Lure and 59 kilometres (37 mi) from Gray, that are the main towns close to Vesoul.
About the biggest cities in the French East region, Vesoul is located 50 kilometres (31 mi) from Besançon, 64 kilometres (40 mi) from Belfort and 105 kilometres (65 mi) from Dijon and 156 kilometres (97 mi) from Nancy.
Situated at the equidistance of Dijon and Mulhouse, Vesoul is 370 kilometres (230 mi) from the city of Paris.
The town of Vesoul is located at the intersection of highways 19 and 57, on the SNCF Paris-Basel railway line .

The area of Vesoul is also included in the Pôle métropolitain Centre Franche-Comté which is a government structure unifying the biggest areas of central Franche-Comté.
There are nine communes that are bordering the town of Vesoul.

Vesoul is crossed by four watercourses : two rivers (Durgeon and Colombine) and two streams (Vaugine and Méline).
All of them are tributaries and sub-tributaries of the Saône, the fourth longest river in France with 473 kilometers long and flowing about ten kilometers from the western side of Vesoul.
Vesoul is located in the easter part of France, about 100 kilometers away from the Germany and the Switzerland's border and between the Jura and the Vosges's mountain ranges. Vesoul is also situated in the center of the Haute-Saône, which is in the nord of Bourgogne-Franche-Comté. Inside of this region, Vesoul is included in the Pays de Vesoul et du Val de Saône, a geographical region composing of the Vesoul's area and the northern part of the river Saône.
By the road, Vesoul is 32 kilometres (20 mi) from Luxeuil-les-Bains, 30 kilometres (19 mi) from Lure and 59 kilometres (37 mi) from Gray, that are the main towns close to Vesoul. About the biggest cities in the French East region, Vesoul is located 50 kilometres (31 mi) from Besançon, 64 kilometres (40 mi) from Belfort and 105 kilometres (65 mi) from Dijon and 156 kilometres (97 mi) from Nancy. Situated at the equidistance of Dijon and Mulhouse, Vesoul is 370 kilometres (230 mi) from the city of Paris. The town of Vesoul is located at the intersection of highways 19 and 57, on the SNCF Paris-Basel railway line .
The area of Vesoul is also included in the Pôle métropolitain Centre Franche-Comté which is a government structure unifying the biggest areas of central Franche-Comté. There are nine communes that are bordering the town of Vesoul.
Vesoul is crossed by four watercourses : two rivers (Durgeon and Colombine) and two streams (Vaugine and Méline). All of them are tributaries and sub-tributaries of the Saône, the fourth longest river in France with 473 kilometers long and flowing about ten kilometers from the western side of Vesoul.
Vesoul