During the 2010–11 season, after the departure of first and second captains of Real Madrid, Raúl and Guti respectively, Casillas was selected as first captain with new vice-captains Sergio Ramos, Marcelo and Gonzalo Higuaín.

During the 2011–12 season, Casillas won the IFFHS Best Goalkeeper award, making him only the second goalkeeper behind Gianluigi Buffon to win it four times and the only goalkeeper to win the award four times in a row.
Casillas played his 600th match for Real Madrid on 22 January 2012 in a 4–1 win against Athletic Bilbao.
On 2 May 2012, Casillas clinched his fifth La Liga title and his first as a captain of Real Madrid, with a 3–0 win in Bilbao.

On 22 December 2012, Casillas was dropped by José Mourinho for a Liga match against Málaga in favour of Antonio Adán.
This was the beginning of a series of sour disagreements between the Portuguese coach and the player, some of which, along with other internal affairs, were allegedly aired to the press by Casillas himself.
This generated a shift in the opinion of certain sectors of Real Madrid's fans, who gave Casillas the nickname "topor" (a portmanteau of "topo," and "portero," Spanish for "mole" and "goalkeeper," respectively).
During the 2012–13 season, Casillas won the IFFHS Best Goalkeeper Award for the fifth consecutive time, making him the only goalkeeper in history to have ever won that award five times (in a row).

In January 2013, after a serious injury to Casillas, Mourinho signed Diego López from Sevilla.
López was named first-choice 'keeper ahead of Antonio Adán and kept his place in the team even after Casillas had returned from injury.
After the 2012–13 season, Mourinho left Madrid and soon after his departure, Spanish midfielder Andrés Iniesta criticised him for benching Casillas.

In the middle of 2013, it was announced that Carlo Ancelotti would be Real Madrid's head coach for the 2013–14 season.
Real Madrid started the season with a 2–1 victory over Real Betis in which Casillas was benched once again.
He made his first start in 238 days in the Champions League group stage match against Galatasaray, but was injured in the 14th minute after Sergio Ramos caught him with an accidental elbow as the goalkeeper came from his line to make a routine catch.
Despite being the club's second-choice 'keeper in La Liga, behind Diego López, Casillas continued to be Madrid's first choice keeper in the Champions League and Copa del Rey, setting a new record of 962 minutes without conceding a goal in the latter competition.
In February 2014, he became the first goalkeeper to play in every round of the Copa del Rey prior to the final without conceding a goal.
On 16 April, he captained Madrid in the final as they beat rivals Barcelona 2–1 at Valencia's Mestalla Stadium.
On 24 May 2014, Casillas captained Real Madrid in the 2014 Champions League final, winning the title for the third time in his career with a 4–1 win over Atlético Madrid in Lisbon; this was the tenth time Real Madrid had won the trophy.
Although Diego Godín's opening goal resulted from an error by Casillas, Sergio Ramos tied the match for Real Madrid in injury time; the club went on to win the title in extra-time.

Following the Champions League win, the 2014–15 season saw Casillas return to being the club's first choice goalkeeper, despite competition from new arrival Keylor Navas, as he then went on to win the UEFA Super Cup, with Real Madrid defeating Sevilla 2–0 on 12 August 2014.
He then also won the FIFA Club World Cup later that year, making his 700th appearance for Madrid on 20 December 2014, in the 2014 FIFA Club World Cup Final, as Real Madrid defeated San Lorenzo 2–0.
During the 2010–11 season, after the departure of first and second captains of Real Madrid, Raúl and Guti respectively, Casillas was selected as first captain with new vice-captains Sergio Ramos, Marcelo and Gonzalo Higuaín.
During the 2011–12 season, Casillas won the IFFHS Best Goalkeeper award, making him only the second goalkeeper behind Gianluigi Buffon to win it four times and the only goalkeeper to win the award four times in a row. Casillas played his 600th match for Real Madrid on 22 January 2012 in a 4–1 win against Athletic Bilbao. On 2 May 2012, Casillas clinched his fifth La Liga title and his first as a captain of Real Madrid, with a 3–0 win in Bilbao.
On 22 December 2012, Casillas was dropped by José Mourinho for a Liga match against Málaga in favour of Antonio Adán. This was the beginning of a series of sour disagreements between the Portuguese coach and the player, some of which, along with other internal affairs, were allegedly aired to the press by Casillas himself. This generated a shift in the opinion of certain sectors of Real Madrid's fans, who gave Casillas the nickname "topor" (a portmanteau of "topo," and "portero," Spanish for "mole" and "goalkeeper," respectively). During the 2012–13 season, Casillas won the IFFHS Best Goalkeeper Award for the fifth consecutive time, making him the only goalkeeper in history to have ever won that award five times (in a row).
In January 2013, after a serious injury to Casillas, Mourinho signed Diego López from Sevilla. López was named first-choice 'keeper ahead of Antonio Adán and kept his place in the team even after Casillas had returned from injury. After the 2012–13 season, Mourinho left Madrid and soon after his departure, Spanish midfielder Andrés Iniesta criticised him for benching Casillas.
In the middle of 2013, it was announced that Carlo Ancelotti would be Real Madrid's head coach for the 2013–14 season. Real Madrid started the season with a 2–1 victory over Real Betis in which Casillas was benched once again. He made his first start in 238 days in the Champions League group stage match against Galatasaray, but was injured in the 14th minute after Sergio Ramos caught him with an accidental elbow as the goalkeeper came from his line to make a routine catch. Despite being the club's second-choice 'keeper in La Liga, behind Diego López, Casillas continued to be Madrid's first choice keeper in the Champions League and Copa del Rey, setting a new record of 962 minutes without conceding a goal in the latter competition. In February 2014, he became the first goalkeeper to play in every round of the Copa del Rey prior to the final without conceding a goal. On 16 April, he captained Madrid in the final as they beat rivals Barcelona 2–1 at Valencia's Mestalla Stadium. On 24 May 2014, Casillas captained Real Madrid in the 2014 Champions League final, winning the title for the third time in his career with a 4–1 win over Atlético Madrid in Lisbon; this was the tenth time Real Madrid had won the trophy. Although Diego Godín's opening goal resulted from an error by Casillas, Sergio Ramos tied the match for Real Madrid in injury time; the club went on to win the title in extra-time.
Following the Champions League win, the 2014–15 season saw Casillas return to being the club's first choice goalkeeper, despite competition from new arrival Keylor Navas, as he then went on to win the UEFA Super Cup, with Real Madrid defeating Sevilla 2–0 on 12 August 2014. He then also won the FIFA Club World Cup later that year, making his 700th appearance for Madrid on 20 December 2014, in the 2014 FIFA Club World Cup Final, as Real Madrid defeated San Lorenzo 2–0.
Iker Casillas