In 1494, at the age of 31, Pico died under mysterious circumstances along with his friend Angelo Poliziano.
It was rumoured that his own secretary had poisoned him because Pico had become too close to Savonarola.
He was interred together with Girolamo Benivieni at San Marco, and Savonarola delivered the funeral oration.
Ficino wrote: 
Our dear Pico left us on the same day that Charles VIII was entering Florence, and the tears of men of letters compensated for the joy of the people.
Without the light brought by the king of France, Florence might perhaps have never seen a more somber day than that which extinguished Mirandola's light.

In 2007, the bodies of Poliziano and Pico were exhumed from the Church of San Marco in Florence to establish the causes of their deaths.
Forensic tests showed that both Poliziano and Pico likely died of arsenic poisoning, possibly at the order of Lorenzo's successor, Piero de' Medici.
In 1494, at the age of 31, Pico died under mysterious circumstances along with his friend Angelo Poliziano. It was rumoured that his own secretary had poisoned him because Pico had become too close to Savonarola. He was interred together with Girolamo Benivieni at San Marco, and Savonarola delivered the funeral oration. Ficino wrote: 
Our dear Pico left us on the same day that Charles VIII was entering Florence, and the tears of men of letters compensated for the joy of the people. Without the light brought by the king of France, Florence might perhaps have never seen a more somber day than that which extinguished Mirandola's light.
In 2007, the bodies of Poliziano and Pico were exhumed from the Church of San Marco in Florence to establish the causes of their deaths. Forensic tests showed that both Poliziano and Pico likely died of arsenic poisoning, possibly at the order of Lorenzo's successor, Piero de' Medici.
Giovanni Pico della Mirandola