Around 1927, she returned to New York, worked as a fashion model, a circus hand, a clerk in a store, joined a stock company to become an actress, and performed on Broadway.
In 1930, she starred with James Cagney in Penny Arcade on Broadway.
Penny Arcade lasted only three weeks, but Al Jolson saw it and bought the rights to the play for $20,000.
He then sold the rights to Warner Bros., with the proviso that Blondell and Cagney be cast in the film version, named Sinners' Holiday (1930).
Placed under contract by Warner Bros., she moved to Hollywood, where studio boss Jack L. Warner wanted her to change her name to "Inez Holmes", but Blondell refused.
She began to appear in short subjects and was named as one of the WAMPAS Baby Stars in 1931.

Blondell was paired several more times with James Cagney in films, including The Public Enemy (1931), and she was one-half of a gold-digging duo with Glenda Farrell in nine films.
During the Great Depression, Blondell was one of the highest-paid individuals in the United States.
Her stirring rendition of "Remember My Forgotten Man" in the Busby Berkeley production of Gold Diggers of 1933, in which she co-starred with Dick Powell and Ruby Keeler, became an anthem for the frustrations of unemployed people and the government's failed economic policies.
In 1937, she starred opposite Errol Flynn in The Perfect Specimen.
By the end of the decade, she had made nearly 50 films.
She left Warner Bros. in 1939.

In 1943, Blondell returned to Broadway as the star of Mike Todd's short-lived production of The Naked Genius, a comedy written by Gypsy Rose Lee.
She was well received in her later films, despite being relegated to character and supporting roles after 1945, when she was billed below the title for the first time in 14 years in Adventure, which starred Clark Gable and Greer Garson.
She was also featured prominently in A Tree Grows in Brooklyn (1945) and Nightmare Alley (1947).
In 1948, she left the screen for three years and concentrated on theater, performing in summer stock and touring with Cole Porter's musical, Something for the Boys.
She later reprised her role of Aunt Sissy in the musical version of A Tree Grows in Brooklyn for the national tour and played the nagging mother, Mae Peterson, in the national tour of Bye Bye Birdie.

Blondell returned to Hollywood in 1950.
Her performance in her next film, The Blue Veil (1951), earned her an Academy Award nomination for Best Actress in a Supporting Role.
She played supporting roles in The Opposite Sex (1956), Desk Set (1957), and Will Success Spoil Rock Hunter? (
1957).
She received considerable acclaim for her performance as Lady Fingers in Norman Jewison's The Cincinnati Kid (1965), garnering a Golden Globe nomination and National Board of Review win for Best Supporting Actress.
John Cassavetes cast her as a cynical, aging playwright in his film Opening Night (1977).
Blondell was widely seen in two films released not long before her death – Grease (1978), and the remake of The Champ (1979) with Jon Voight and Rick Schroder.
She also appeared in two films released after her death – The Glove (1979), and The Woman Inside (1981).

Blondell also guest-starred in various television programs, including three 1963 episodes as the character Aunt Win in the CBS sitcom The Real McCoys, starring Walter Brennan and Richard Crenna.

Also in 1963, Blondell was cast as the widowed Lucy Tutaine in the episode, "The Train and Lucy Tutaine", on the syndicated anthology series, Death Valley Days, hosted by Stanley Andrews.
In the story line, Lucy sues a railroad company, against great odds, for causing the death of her cow.
Noah Beery Jr., was cast as Abel.

In 1964, she appeared in the episode "What's in the Box?"
of The Twilight Zone.
She guest-starred in the episode "You're All Right, Ivy" on Jack Palance's circus drama, The Greatest Show on Earth, which aired on ABC in the 1963–64 television season.
Her co-stars in the segment were Joe E. Brown and Buster Keaton.
In 1965, she was in the running to replace Vivian Vance as Lucille Ball's sidekick on the hit CB
Around 1927, she returned to New York, worked as a fashion model, a circus hand, a clerk in a store, joined a stock company to become an actress, and performed on Broadway. In 1930, she starred with James Cagney in Penny Arcade on Broadway. Penny Arcade lasted only three weeks, but Al Jolson saw it and bought the rights to the play for $20,000. He then sold the rights to Warner Bros., with the proviso that Blondell and Cagney be cast in the film version, named Sinners' Holiday (1930). Placed under contract by Warner Bros., she moved to Hollywood, where studio boss Jack L. Warner wanted her to change her name to "Inez Holmes", but Blondell refused. She began to appear in short subjects and was named as one of the WAMPAS Baby Stars in 1931.
Blondell was paired several more times with James Cagney in films, including The Public Enemy (1931), and she was one-half of a gold-digging duo with Glenda Farrell in nine films. During the Great Depression, Blondell was one of the highest-paid individuals in the United States. Her stirring rendition of "Remember My Forgotten Man" in the Busby Berkeley production of Gold Diggers of 1933, in which she co-starred with Dick Powell and Ruby Keeler, became an anthem for the frustrations of unemployed people and the government's failed economic policies. In 1937, she starred opposite Errol Flynn in The Perfect Specimen. By the end of the decade, she had made nearly 50 films. She left Warner Bros. in 1939.
In 1943, Blondell returned to Broadway as the star of Mike Todd's short-lived production of The Naked Genius, a comedy written by Gypsy Rose Lee. She was well received in her later films, despite being relegated to character and supporting roles after 1945, when she was billed below the title for the first time in 14 years in Adventure, which starred Clark Gable and Greer Garson. She was also featured prominently in A Tree Grows in Brooklyn (1945) and Nightmare Alley (1947). In 1948, she left the screen for three years and concentrated on theater, performing in summer stock and touring with Cole Porter's musical, Something for the Boys. She later reprised her role of Aunt Sissy in the musical version of A Tree Grows in Brooklyn for the national tour and played the nagging mother, Mae Peterson, in the national tour of Bye Bye Birdie.
Blondell returned to Hollywood in 1950. Her performance in her next film, The Blue Veil (1951), earned her an Academy Award nomination for Best Actress in a Supporting Role. She played supporting roles in The Opposite Sex (1956), Desk Set (1957), and Will Success Spoil Rock Hunter? (1957). She received considerable acclaim for her performance as Lady Fingers in Norman Jewison's The Cincinnati Kid (1965), garnering a Golden Globe nomination and National Board of Review win for Best Supporting Actress. John Cassavetes cast her as a cynical, aging playwright in his film Opening Night (1977). Blondell was widely seen in two films released not long before her death – Grease (1978), and the remake of The Champ (1979) with Jon Voight and Rick Schroder. She also appeared in two films released after her death – The Glove (1979), and The Woman Inside (1981).
Blondell also guest-starred in various television programs, including three 1963 episodes as the character Aunt Win in the CBS sitcom The Real McCoys, starring Walter Brennan and Richard Crenna.
Also in 1963, Blondell was cast as the widowed Lucy Tutaine in the episode, "The Train and Lucy Tutaine", on the syndicated anthology series, Death Valley Days, hosted by Stanley Andrews. In the story line, Lucy sues a railroad company, against great odds, for causing the death of her cow. Noah Beery Jr., was cast as Abel.
In 1964, she appeared in the episode "What's in the Box?" of The Twilight Zone. She guest-starred in the episode "You're All Right, Ivy" on Jack Palance's circus drama, The Greatest Show on Earth, which aired on ABC in the 1963–64 television season. Her co-stars in the segment were Joe E. Brown and Buster Keaton. In 1965, she was in the running to replace Vivian Vance as Lucille Ball's sidekick on the hit CB
Joan Blondell