Tyrrell had given Depailler drives at France and Watkins Glen in 1972.
Using one of the older cars, Depailler had finished in seventh place in the latter race.
So in December 1973 Depailler was chosen with Scheckter to drive for Tyrrell, to replace the deceased François Cevert and retired Jackie Stewart.
Depailler captured the pole for the 1974 Swedish Grand Prix, his 9th race as a Formula One driver.
He negotiated the 2.49-mile (4.01 km) Anderstorp course in a time of 1 minute, 24.758 seconds, for an average speed of 105.8 miles per hour.
Depailler would finish 2nd in the race behind teammate Jody Scheckter; this proved his only podium of the year.

In January 1975 Depailler was given 25–1 odds of becoming the 1975 Formula One World Champion.
He finished 5th in the 1975 Argentine Grand Prix in Buenos Aires.
He took 3rd at Kyalami in the 1975 South African Grand Prix.
Depailler stayed behind 2nd-place finisher, Carlos Reutemann, throughout the 78 laps of the event.
On the first day of qualifying for the 1975 United States Grand Prix, Depailler crashed his Tyrrell into a catch fence at Watkins Glen.
He was not injured.

Depailler came in 2nd in the 1976 Brazilian Grand Prix at Interlagos.
With a speed of 86.69 mph (139.51 km/h), in qualifying for the 1976 United States Grand Prix West, Depailler exceeded his lap record at Monte Carlo by 4 mph (6.4 km/h), lapping the street course in Long Beach, California in 1:23.884.
He ended up 2nd to Clay Regazzoni on the 2nd day of qualifying, with a speed of 87.31 mph (140.51 km/h).
Depailler gained a 3rd-place finish but drew the ire of rival James Hunt, who went out on the 4th lap.
Hunt claimed that Depailler forced him off the track and shook his fist at him after his exit from the race.
Depailler, who wrestled with brake trouble, claimed that he did not see the English driver in his mirrors.
Depailler placed his six-wheeled Tyrrell in 3rd position for the start of the 1976 Monaco Grand Prix with a time of 1:30.33.
The Tyrrells of Scheckter and Depailler were the only cars able to stay on the same lap with Lauda's Ferrari, who won from pole position.
Depailler was 2nd to Hunt in the 1976 French Grand Prix at Le Castellet.
He achieved a time of 1:41:11.30.
Hunt held off a determined Depailler at Mosport Park in the 1976 Canadian Grand Prix.
Both drivers were ill at the conclusion of the event, with Depailler having inhaled fumes over the last third of the race.
He lost consciousness after pulling his car off at the first corner following the finish.
He regained consciousness momentarily.
Depailler finished 2nd ahead of Hunt (who nevertheless secured the 1976 Drivers' Championship by finishing third) at the 1976 Japanese Grand Prix, despite encountering tire problems as the Fuji Speedway track dried from heavy rains.

He skidded off the Interlagos track at Sao Paulo during the 1977 Brazilian Grand Prix.
He was hospitalized with a leg injury.
Depailler qualified in the 6th row, 12th position, for the 1977 United States Grand Prix West.
His time was 87.959.
In December 1977 Depailler was promoted to the number one driver for Tyrrell, when Ronnie Peterson left to drive for
Lotus.
At the same time Tyrrell revealed that it was quitting its experiment with six-wheeled Formula One cars.

Depailler was 3rd in the 1978 Argentine Grand Prix in an Elf-Tyrrell.
He covered the 52 laps in 1:37:18.11.
Peterson passed Depailler on the last turn of the last lap at Kyalami, to claim the 1978 South African Grand Prix.
Depailler's car was running short of fuel, allowing Peterson to erase a 9-second gap to win.

Depailler climbed from 12th starting place to end in 3rd position in the 1978 United States Grand Prix West.
Depailler gained his first Formula One triumph by winning the 1978 Monaco Grand Prix.

Piloting a Tyrrell-Ford 008, Depailler secured the 36th annual event, with a time of 1:55:14.66 over 75 laps, for an average speed of 80.359 mph (129.325 km/h).
It was his first victory in 69 championship races, although he had been 2nd eight times.
Tyrrell had given Depailler drives at France and Watkins Glen in 1972. Using one of the older cars, Depailler had finished in seventh place in the latter race. So in December 1973 Depailler was chosen with Scheckter to drive for Tyrrell, to replace the deceased François Cevert and retired Jackie Stewart. Depailler captured the pole for the 1974 Swedish Grand Prix, his 9th race as a Formula One driver. He negotiated the 2.49-mile (4.01 km) Anderstorp course in a time of 1 minute, 24.758 seconds, for an average speed of 105.8 miles per hour. Depailler would finish 2nd in the race behind teammate Jody Scheckter; this proved his only podium of the year.
In January 1975 Depailler was given 25–1 odds of becoming the 1975 Formula One World Champion. He finished 5th in the 1975 Argentine Grand Prix in Buenos Aires. He took 3rd at Kyalami in the 1975 South African Grand Prix. Depailler stayed behind 2nd-place finisher, Carlos Reutemann, throughout the 78 laps of the event. On the first day of qualifying for the 1975 United States Grand Prix, Depailler crashed his Tyrrell into a catch fence at Watkins Glen. He was not injured.
Depailler came in 2nd in the 1976 Brazilian Grand Prix at Interlagos. With a speed of 86.69 mph (139.51 km/h), in qualifying for the 1976 United States Grand Prix West, Depailler exceeded his lap record at Monte Carlo by 4 mph (6.4 km/h), lapping the street course in Long Beach, California in 1:23.884. He ended up 2nd to Clay Regazzoni on the 2nd day of qualifying, with a speed of 87.31 mph (140.51 km/h). Depailler gained a 3rd-place finish but drew the ire of rival James Hunt, who went out on the 4th lap. Hunt claimed that Depailler forced him off the track and shook his fist at him after his exit from the race. Depailler, who wrestled with brake trouble, claimed that he did not see the English driver in his mirrors. Depailler placed his six-wheeled Tyrrell in 3rd position for the start of the 1976 Monaco Grand Prix with a time of 1:30.33. The Tyrrells of Scheckter and Depailler were the only cars able to stay on the same lap with Lauda's Ferrari, who won from pole position. Depailler was 2nd to Hunt in the 1976 French Grand Prix at Le Castellet. He achieved a time of 1:41:11.30. Hunt held off a determined Depailler at Mosport Park in the 1976 Canadian Grand Prix. Both drivers were ill at the conclusion of the event, with Depailler having inhaled fumes over the last third of the race. He lost consciousness after pulling his car off at the first corner following the finish. He regained consciousness momentarily. Depailler finished 2nd ahead of Hunt (who nevertheless secured the 1976 Drivers' Championship by finishing third) at the 1976 Japanese Grand Prix, despite encountering tire problems as the Fuji Speedway track dried from heavy rains.
He skidded off the Interlagos track at Sao Paulo during the 1977 Brazilian Grand Prix. He was hospitalized with a leg injury. Depailler qualified in the 6th row, 12th position, for the 1977 United States Grand Prix West. His time was 87.959. In December 1977 Depailler was promoted to the number one driver for Tyrrell, when Ronnie Peterson left to drive for
Lotus. At the same time Tyrrell revealed that it was quitting its experiment with six-wheeled Formula One cars.
Depailler was 3rd in the 1978 Argentine Grand Prix in an Elf-Tyrrell. He covered the 52 laps in 1:37:18.11. Peterson passed Depailler on the last turn of the last lap at Kyalami, to claim the 1978 South African Grand Prix. Depailler's car was running short of fuel, allowing Peterson to erase a 9-second gap to win.
Depailler climbed from 12th starting place to end in 3rd position in the 1978 United States Grand Prix West. Depailler gained his first Formula One triumph by winning the 1978 Monaco Grand Prix.
Piloting a Tyrrell-Ford 008, Depailler secured the 36th annual event, with a time of 1:55:14.66 over 75 laps, for an average speed of 80.359 mph (129.325 km/h). It was his first victory in 69 championship races, although he had been 2nd eight times.
Patrick Depailler