Nkufo played for Lausanne Sport, FC Echallens, Al-Arabi, Yverdon-Sport FC, Grasshopper Club Zürich, AC Lugano, FC Lucerne, Mainz 05, Hannover 96, FC Twente and Seattle Sounders FC.

In early 2010, Nkufo left Twente and was linked to sign with the Major League Soccer team Seattle Sounders FC.
On 4 March 2010, the Sounders confirmed that they had signed Nkufo and that he would be joining the Sounders' squad on 13 July 2010 when his contract with Twente expired.
In his final season with Twente, Nkufo scored 12 Eredivisie goals helping the club to their first league title in their 45-year history.
Nkufo made 223 Eredivisie appearances for Twente, and scored 114 goals - a club record.
Twente erected a statue in his honour outside of the stadium following his departure.

His first appearance for the Sounders was on 18 July 2010 during a friendly vs. Celtic.
Nkufo was the first Sounders player to record a hat-trick in league play, doing so against the Columbus Crew on 18 September 2010.
It ended a scoreless drought of 415 minutes for him after joining the club.
On 5 October 2010, Nkufo featured in the final of the U.S. Open Cup as the Sounders defeated the Columbus Crew by a score of 2–1.
On 15 March 2011, Seattle and Nkufo agreed mutually to the termination of his deal.
Nkufo announced his retirement thirteen days later.
Nkufo played for Lausanne Sport, FC Echallens, Al-Arabi, Yverdon-Sport FC, Grasshopper Club Zürich, AC Lugano, FC Lucerne, Mainz 05, Hannover 96, FC Twente and Seattle Sounders FC.
In early 2010, Nkufo left Twente and was linked to sign with the Major League Soccer team Seattle Sounders FC. On 4 March 2010, the Sounders confirmed that they had signed Nkufo and that he would be joining the Sounders' squad on 13 July 2010 when his contract with Twente expired. In his final season with Twente, Nkufo scored 12 Eredivisie goals helping the club to their first league title in their 45-year history. Nkufo made 223 Eredivisie appearances for Twente, and scored 114 goals - a club record. Twente erected a statue in his honour outside of the stadium following his departure.
His first appearance for the Sounders was on 18 July 2010 during a friendly vs. Celtic. Nkufo was the first Sounders player to record a hat-trick in league play, doing so against the Columbus Crew on 18 September 2010. It ended a scoreless drought of 415 minutes for him after joining the club. On 5 October 2010, Nkufo featured in the final of the U.S. Open Cup as the Sounders defeated the Columbus Crew by a score of 2–1. On 15 March 2011, Seattle and Nkufo agreed mutually to the termination of his deal. Nkufo announced his retirement thirteen days later.
Blaise Nkufo