Aside from the Binondo Church, a number of other notable structures are (or were) located within the vicinity of Plaza San Lorenzo Ruiz.
 The largest building to have been built around the plaza was the La Insular Cigar and Cigarette Factory, which was opened in 1883 after the lifting of the Spanish tobacco monopoly three years earlier.
 Destroyed by fire during the Battle of Manila, the site is now occupied by the Wellington Building, which was once the headquarters of the Metropolitan Bank and Trust Company (Metrobank), founded by Chinese Filipino businessman George Ty, and still home to the Binondo offices of a number of Metrobank-affiliated companies.
 Beside it was the Hotel de Oriente, then the most popular hotel in Manila, where José Rizal stayed in Room 22, and which also served as the erstwhile headquarters of the National Library of the Philippines.
 While the Hotel de Oriente, unlike the La Insular Cigar and Cigarette Factory, was only partially destroyed in the Battle of Manila, it was demolished afterward, and the site is now occupied by Tytana Plaza, home to the current Binondo offices of Metrobank.
A replica of the Hotel de Oriente today stands in the Las Casas Filipinas de Acuzar complex in Bagac, Bataan.


On the northern end of the plaza is a building formerly housing the Binondo offices of Bank of the Philippine Islands (BPI), which is currently home to the Binondo branches of Pancake House, Starbucks and Yellow Cab Pizza.
 While the Binondo branch has moved to a taller building next door, at the corner with Reina Regente Street, BPI currently maintains its main Binondo offices at the BPI Building along Quintin Paredes Street.
Aside from the Binondo Church, a number of other notable structures are (or were) located within the vicinity of Plaza San Lorenzo Ruiz.  The largest building to have been built around the plaza was the La Insular Cigar and Cigarette Factory, which was opened in 1883 after the lifting of the Spanish tobacco monopoly three years earlier.  Destroyed by fire during the Battle of Manila, the site is now occupied by the Wellington Building, which was once the headquarters of the Metropolitan Bank and Trust Company (Metrobank), founded by Chinese Filipino businessman George Ty, and still home to the Binondo offices of a number of Metrobank-affiliated companies.  Beside it was the Hotel de Oriente, then the most popular hotel in Manila, where José Rizal stayed in Room 22, and which also served as the erstwhile headquarters of the National Library of the Philippines.  While the Hotel de Oriente, unlike the La Insular Cigar and Cigarette Factory, was only partially destroyed in the Battle of Manila, it was demolished afterward, and the site is now occupied by Tytana Plaza, home to the current Binondo offices of Metrobank. A replica of the Hotel de Oriente today stands in the Las Casas Filipinas de Acuzar complex in Bagac, Bataan.

On the northern end of the plaza is a building formerly housing the Binondo offices of Bank of the Philippine Islands (BPI), which is currently home to the Binondo branches of Pancake House, Starbucks and Yellow Cab Pizza.  While the Binondo branch has moved to a taller building next door, at the corner with Reina Regente Street, BPI currently maintains its main Binondo offices at the BPI Building along Quintin Paredes Street.
Plaza San Lorenzo Ruiz