The last restoration, after the restoration during the papacy of Sixtus IV, occurred in 1636, when the facade, with lower doric and upper ionic order, was reconstructed in 1636, after the cyclone of 1634.
The nave is flanked by pilasters that incorporate Ancient Roman marble and granite columns, putatively from the former Temple of Neptune on the Palatine.

The ceiling is colorfully decorated with elaborate framed designs (cassetone) and has a central frescoed panel depicting the Martyrdom of Anastasia (1722) by Michelangelo Cerruti; the work was pursued under the patronage of the Cardinal Nuno Cardeal da Cunha e Ataíde.
The presbytery was richly decorated in 1705 with marble by the Febei family rebuilt with an endowment of the cardinal Giambattista Costaguti.
Under the main altar is said to sheltered the relics of the titular saint.
The main altarpiece behind the altar depicts a Nativity by Lazzaro Baldi.
The altar at the base houses a statue of Saint Anastasia by Ercole Ferrata.
The recumbent sculpture of the dying saint, laid atop a flaming pyre, was influenced by Bernini's Beata Ludovica Albertoni.

The first chapel to the right, near the entrance, has a painting of St John the Baptist by Pier Francesco Mola.
While the last chapel on the right has a fresco depicting Scenes from the lives of Saints Carlo Borromeo and Filippo Neri by Lazzaro Baldi.
The right transept has a painting of St Toribio (1726) by Francesco Trevisani.
The left transept has a Madonna of the Rosary also by Baldi, and the tomb of Cardinal and philologist Angelo Mai by the late neoclassical sculptor Giovanni Maria Benzoni.
The last chapel to the left, is dedicated to St Jerome, and has an altarpiece depicting this saint by Domenichino.
The chalice used by the saint was said to be housed in this chapel.
The other chapel has a Saints Giorgio and Bishop Publio by Etienne Parrocel.
The last restoration, after the restoration during the papacy of Sixtus IV, occurred in 1636, when the facade, with lower doric and upper ionic order, was reconstructed in 1636, after the cyclone of 1634. The nave is flanked by pilasters that incorporate Ancient Roman marble and granite columns, putatively from the former Temple of Neptune on the Palatine.
The ceiling is colorfully decorated with elaborate framed designs (cassetone) and has a central frescoed panel depicting the Martyrdom of Anastasia (1722) by Michelangelo Cerruti; the work was pursued under the patronage of the Cardinal Nuno Cardeal da Cunha e Ataíde. The presbytery was richly decorated in 1705 with marble by the Febei family rebuilt with an endowment of the cardinal Giambattista Costaguti. Under the main altar is said to sheltered the relics of the titular saint. The main altarpiece behind the altar depicts a Nativity by Lazzaro Baldi. The altar at the base houses a statue of Saint Anastasia by Ercole Ferrata. The recumbent sculpture of the dying saint, laid atop a flaming pyre, was influenced by Bernini's Beata Ludovica Albertoni.
The first chapel to the right, near the entrance, has a painting of St John the Baptist by Pier Francesco Mola. While the last chapel on the right has a fresco depicting Scenes from the lives of Saints Carlo Borromeo and Filippo Neri by Lazzaro Baldi. The right transept has a painting of St Toribio (1726) by Francesco Trevisani. The left transept has a Madonna of the Rosary also by Baldi, and the tomb of Cardinal and philologist Angelo Mai by the late neoclassical sculptor Giovanni Maria Benzoni. The last chapel to the left, is dedicated to St Jerome, and has an altarpiece depicting this saint by Domenichino. The chalice used by the saint was said to be housed in this chapel. The other chapel has a Saints Giorgio and Bishop Publio by Etienne Parrocel.
Sant'Anastasia al Palatino