Planning for the cathedral began under the authority of Archbishop Peter Richard Kenrick in the 1870s and 1880s, and a fund was created for the construction of the building by Archbishop John Joseph Kain.
A formal organization promoting the new cathedral was created on April 28, 1871, and among the members of the St. Louis Cathedral Building Association were Archbishop Kenrick, Bishop Patrick John Ryan, and a variety of local businessmen.
Initial site selection indicated that the new cathedral would be built on a city block bounded by 22nd and 23rd streets, and by Pine and Chestnut streets, at a location east of the actual construction site.

However, the initiative for construction was only begun after the elevation of Archbishop John J. Glennon.
The architecture firm of Barnett, Haynes & Barnett was selected, and Thomas P. Barnett led the design team for the project.
 A ceremony was conducted on May 1, 1907, for the groundbreaking of the site, and a formal laying of the building's cornerstone took place on October 18, 1908.
By 1914, enough of the building was complete for a dedication ceremony, yet full consecration did not take place until June 29, 1926.
Even after consecration, completion of the cathedral's mosaics was not accomplished until 1988.

The grounds of the Cathedral also contain the distinctive circular Chancery Building, circa 1965, designed by the Peruvian-American modernist architect Wenceslaus Sarmiento.
Planning for the cathedral began under the authority of Archbishop Peter Richard Kenrick in the 1870s and 1880s, and a fund was created for the construction of the building by Archbishop John Joseph Kain. A formal organization promoting the new cathedral was created on April 28, 1871, and among the members of the St. Louis Cathedral Building Association were Archbishop Kenrick, Bishop Patrick John Ryan, and a variety of local businessmen. Initial site selection indicated that the new cathedral would be built on a city block bounded by 22nd and 23rd streets, and by Pine and Chestnut streets, at a location east of the actual construction site.
However, the initiative for construction was only begun after the elevation of Archbishop John J. Glennon. The architecture firm of Barnett, Haynes & Barnett was selected, and Thomas P. Barnett led the design team for the project.  A ceremony was conducted on May 1, 1907, for the groundbreaking of the site, and a formal laying of the building's cornerstone took place on October 18, 1908. By 1914, enough of the building was complete for a dedication ceremony, yet full consecration did not take place until June 29, 1926. Even after consecration, completion of the cathedral's mosaics was not accomplished until 1988.
The grounds of the Cathedral also contain the distinctive circular Chancery Building, circa 1965, designed by the Peruvian-American modernist architect Wenceslaus Sarmiento.
Cathedral Basilica of Saint Louis (St. Louis)