After Park's death in 1912, his house was sold and converted into office space.
 The house was used as a Red Cross workshop during World War I, and served as a medical clinic in the years following the war.
 In 1945, the Knoxville Academy of Medicine, headed by prominent physician Herbert Acuff (who was also instrumental in constructing the nearby Medical Arts Building), purchased and renovated the house.
 The Academy used the house for several decades before relocating to West Knoxville.

In 2002, Gulf and Ohio Railroads CEO Pete Claussen and his wife, Linda, purchased the house for use as the Gulf and Ohio's headquarters.
 Working with architect Lee Ingram of the firm, Brewer Ingram Fuller, the Claussens removed several modern elements and restored the house to its 19th-century appearance.
 These changes included the removal of a 1968 rear medical auxiliary and auditorium, and the restoration of the house's Victorian-era porch.
 The renovations were largely completed in 2007.
After Park's death in 1912, his house was sold and converted into office space.  The house was used as a Red Cross workshop during World War I, and served as a medical clinic in the years following the war.  In 1945, the Knoxville Academy of Medicine, headed by prominent physician Herbert Acuff (who was also instrumental in constructing the nearby Medical Arts Building), purchased and renovated the house.  The Academy used the house for several decades before relocating to West Knoxville.
In 2002, Gulf and Ohio Railroads CEO Pete Claussen and his wife, Linda, purchased the house for use as the Gulf and Ohio's headquarters.  Working with architect Lee Ingram of the firm, Brewer Ingram Fuller, the Claussens removed several modern elements and restored the house to its 19th-century appearance.  These changes included the removal of a 1968 rear medical auxiliary and auditorium, and the restoration of the house's Victorian-era porch.  The renovations were largely completed in 2007.
James Park House