In 2007, Harris worked with Mike Nelson on an audio commentary for RiffTrax.
The two "riffed" on the film Willy Wonka & the Chocolate Factory.
Harris is a big fan of the cult TV series Nelson worked on, Mystery Science Theater 3000.
Harris was interviewed for a 1992 Comedy Central special This Is MST3K hosted by Penn Jillette about the series and its fans.
In 2008, Harris played the title role in Joss Whedon's musical web series Dr. Horrible's Sing-Along Blog alongside Nathan Fillion and Felicia Day.
The first episode of the series debuted on July 15, 2008.
He has also provided his voice for the Disney California Adventure Park attraction California Screamin'.

On December 11, 2010, Harris hosted the Spike Video Game Awards.

In October 2014, Harris released a memoir titled Neil Patrick Harris: Choose Your Own Autobiography, which is structured like a Choose Your Own Adventure book.
His autobiography spent two weeks on The New York Times Best Seller List.
His debut young adult novel, The Magic Misfits, was released in November 2017 and is the first in a four-book series of the same name.
In 2007, Harris worked with Mike Nelson on an audio commentary for RiffTrax. The two "riffed" on the film Willy Wonka & the Chocolate Factory. Harris is a big fan of the cult TV series Nelson worked on, Mystery Science Theater 3000. Harris was interviewed for a 1992 Comedy Central special This Is MST3K hosted by Penn Jillette about the series and its fans. In 2008, Harris played the title role in Joss Whedon's musical web series Dr. Horrible's Sing-Along Blog alongside Nathan Fillion and Felicia Day. The first episode of the series debuted on July 15, 2008. He has also provided his voice for the Disney California Adventure Park attraction California Screamin'.
On December 11, 2010, Harris hosted the Spike Video Game Awards.
In October 2014, Harris released a memoir titled Neil Patrick Harris: Choose Your Own Autobiography, which is structured like a Choose Your Own Adventure book. His autobiography spent two weeks on The New York Times Best Seller List. His debut young adult novel, The Magic Misfits, was released in November 2017 and is the first in a four-book series of the same name.
Neil Patrick Harris