Cavani's first goal of the Serie A season came on 26 August, netting the final goal of Napoli's 3–0 defeat of former club Palermo.
A month later, on 26 September, Cavani scored a mesmerizing hat-trick against Lazio to maintain Napoli's undefeated start to the Serie A season in a 3–0 win.

On 8 November, Cavani scored all four goals, including a half-volley from outside the box and a tremendous free kick, as Napoli came back from 2–1 down to defeat Dnipro Dnipropetrovsk 4–2 in the group stage of the Europa League.
Cavani scored a late penalty in the 94th minute to secure a 2–1 victory over Swedish side AIK on 22 November, sending Napoli through to the next round of the Europa League.
Cavani was the last player ever to score on the Råsunda Stadium which was the stadium that hosted the 1958 FIFA World Cup final.
On 6 January 2013, Cavani netted a perfect hat-trick as Napoli thumped Roma 4–1, gaining ground in the race for the league title as champions Juventus fell to a shock win.
Cavani finished the season as leading Serie A goalscorer, with 29 goals, six ahead of Udinese striker Antonio Di Natale in second.

Towards the end of the season, reports emerged that Cavani would leave Napoli, with Chelsea, Manchester City, Paris Saint-Germain and Real Madrid all believed to be interested.
On 27 May 2013, however, he told that he was not thinking of moving, saying, "Real Madrid, Chelsea and [Manchester] City are interested in me?
I just think about Napoli."
Nonetheless, he continued, "If an important offer were to come in, I will talk with president [Aurelio] De Laurentiis."
He then paid tribute to his time in Italy, saying, "I'm fine in Italy, I have grown as a man there and as a player with the Serie A experience."
Cavani was asked about the interest Chelsea and Manchester City took in him, saying, "I don't know if they made an offer for me, I just know that to be coached by someone like [Man City manager] Manuel Pellegrini or [Chelsea manager] José Mourinho would always be a pleasure."
On 23 June, Napoli club president Aurelio De Laurentiis revealed that Cavani's reported £53 million "buyout clause expires" on 10 August 2013.
Cavani's first goal of the Serie A season came on 26 August, netting the final goal of Napoli's 3–0 defeat of former club Palermo. A month later, on 26 September, Cavani scored a mesmerizing hat-trick against Lazio to maintain Napoli's undefeated start to the Serie A season in a 3–0 win.
On 8 November, Cavani scored all four goals, including a half-volley from outside the box and a tremendous free kick, as Napoli came back from 2–1 down to defeat Dnipro Dnipropetrovsk 4–2 in the group stage of the Europa League. Cavani scored a late penalty in the 94th minute to secure a 2–1 victory over Swedish side AIK on 22 November, sending Napoli through to the next round of the Europa League. Cavani was the last player ever to score on the Råsunda Stadium which was the stadium that hosted the 1958 FIFA World Cup final. On 6 January 2013, Cavani netted a perfect hat-trick as Napoli thumped Roma 4–1, gaining ground in the race for the league title as champions Juventus fell to a shock win. Cavani finished the season as leading Serie A goalscorer, with 29 goals, six ahead of Udinese striker Antonio Di Natale in second.
Towards the end of the season, reports emerged that Cavani would leave Napoli, with Chelsea, Manchester City, Paris Saint-Germain and Real Madrid all believed to be interested. On 27 May 2013, however, he told that he was not thinking of moving, saying, "Real Madrid, Chelsea and [Manchester] City are interested in me? I just think about Napoli." Nonetheless, he continued, "If an important offer were to come in, I will talk with president [Aurelio] De Laurentiis." He then paid tribute to his time in Italy, saying, "I'm fine in Italy, I have grown as a man there and as a player with the Serie A experience." Cavani was asked about the interest Chelsea and Manchester City took in him, saying, "I don't know if they made an offer for me, I just know that to be coached by someone like [Man City manager] Manuel Pellegrini or [Chelsea manager] José Mourinho would always be a pleasure." On 23 June, Napoli club president Aurelio De Laurentiis revealed that Cavani's reported £53 million "buyout clause expires" on 10 August 2013.
Edinson Cavani