President Mikhail Saakashvili of Georgia nominated her as Minister of Foreign Affairs in his new government.
Zourabichvili became the first woman to be appointed to this post in Georgia on 18 March 2004.

Zourabichvili was the Coordinator of the Panel of Experts assisting the UN Security Council’s Iran Sanctions Committee.

As foreign minister of Georgia, Zourabichvili was the main negotiator of the agreement for the withdrawal of Russian military bases from the territory of Georgia, which was signed with Russian Minister of Foreign Affairs Sergey Lavrov on 19 May 2005.
During her tenure as Foreign Minister, the "New Group of Friends of Georgia" was created, bringing together Ukraine, Lithuania, Latvia, Estonia, Romania, Bulgaria, the Czech Republic and Poland to help Georgia's aspirations towards NATO and foster European integration.

Zourabichvili was sacked by Prime Minister Zurab Nogaideli late on 19 October 2005 after a series of disputes with members of Parliament.
She had also been heavily criticized by a number of Georgian ambassadors.
Shortly before her dismissal was announced, Zourabichvili resigned from the French foreign service, which had continued to pay her a salary while she was minister, and announced that she would remain in Georgia to go into politics.
President Mikhail Saakashvili of Georgia nominated her as Minister of Foreign Affairs in his new government. Zourabichvili became the first woman to be appointed to this post in Georgia on 18 March 2004.
Zourabichvili was the Coordinator of the Panel of Experts assisting the UN Security Council’s Iran Sanctions Committee.
As foreign minister of Georgia, Zourabichvili was the main negotiator of the agreement for the withdrawal of Russian military bases from the territory of Georgia, which was signed with Russian Minister of Foreign Affairs Sergey Lavrov on 19 May 2005. During her tenure as Foreign Minister, the "New Group of Friends of Georgia" was created, bringing together Ukraine, Lithuania, Latvia, Estonia, Romania, Bulgaria, the Czech Republic and Poland to help Georgia's aspirations towards NATO and foster European integration.
Zourabichvili was sacked by Prime Minister Zurab Nogaideli late on 19 October 2005 after a series of disputes with members of Parliament. She had also been heavily criticized by a number of Georgian ambassadors. Shortly before her dismissal was announced, Zourabichvili resigned from the French foreign service, which had continued to pay her a salary while she was minister, and announced that she would remain in Georgia to go into politics.
Salome Zourabichvili