On November 15, 2005 Cameron was traded to the San Diego Padres for Xavier Nady.
He won his first National League Gold Glove award during the 2006 season with San Diego.

After leaving the Seattle Mariners in 2004 via free agency, Cameron played his first game back in Seattle during inter-league play in May 2006.
Mariners fans greeted his return with a standing ovation.

On October 31, 2007, it was announced that he had failed a test for banned stimulants for a second time and would miss the first 25 games of the 2008 season.
Cameron has said he believes that a supplement he took was "tainted."
However, given the requirement of two failed drug tests before an announcement is made, this explanation is questionable.
He was just the second major leaguer to be suspended for a second positive test for stimulants, following Neifi Pérez.
On November 15, 2005 Cameron was traded to the San Diego Padres for Xavier Nady. He won his first National League Gold Glove award during the 2006 season with San Diego.
After leaving the Seattle Mariners in 2004 via free agency, Cameron played his first game back in Seattle during inter-league play in May 2006. Mariners fans greeted his return with a standing ovation.
On October 31, 2007, it was announced that he had failed a test for banned stimulants for a second time and would miss the first 25 games of the 2008 season. Cameron has said he believes that a supplement he took was "tainted." However, given the requirement of two failed drug tests before an announcement is made, this explanation is questionable. He was just the second major leaguer to be suspended for a second positive test for stimulants, following Neifi Pérez.
Mike Cameron