The faith community of St. Luke's originated in the home of Francis Eppes (1801–1881), who was the grandson of Thomas Jefferson and an ardent Episcopal churchman and lay reader.
Francis Eppes moved from Virginia to Tallahassee in 1826 and then to the sparsely settled town of Orlando in 1869.
The Eppes, Shine, Summerlin, Westcott, and Greetham families formed a faithful group which became the nucleus for the formation of St. Luke's Mission, which formally organized in 1881 and achieved parish status in 1884.

The General Convention of the Episcopal Church established the Missionary Jurisdiction of South Florida and the Rev. William Crane Gray was elected and consecrated its first bishop.
 He made his home in Orlando and St. Luke's was designated as the Cathedral Church for South Florida on March 31, 1902.
 The first cathedral dean was the Rev. Lucien A. Spencer.
 It was decided that a new cathedral was needed and so the old church was moved in 1922 to make way for a new building.
 The Boston architectural firm of Frohman, Robb, and Little, who designed the Washington National Cathedral, was chosen to design Orlando's new cathedral.

On April 13, 1925, the Rt.
Rev. Cameron Mann laid the cornerstone and by 1926 the building was only partially constructed, but usable.
 A financial depression was affecting Florida at the time and there was no money to complete it at that time so a temporary wall was constructed at the altar end of the church.
 When the Very Rev. Charles T. Gaskell was dean from 1971 to 1973, the nave was renovated, the choir gallery was built over the narthex and an 88-rank pipe organ was installed.
 In a construction project from 1986 to 1987, the temporary wall was removed and the cathedral was completed similar to its original plans when the Very Rev. Harry Sherman was dean.
The completed cathedral includes an apse, ambulatory, priests and working sacristies, a bell tower and the St. Mary Chapel.
The faith community of St. Luke's originated in the home of Francis Eppes (1801–1881), who was the grandson of Thomas Jefferson and an ardent Episcopal churchman and lay reader. Francis Eppes moved from Virginia to Tallahassee in 1826 and then to the sparsely settled town of Orlando in 1869. The Eppes, Shine, Summerlin, Westcott, and Greetham families formed a faithful group which became the nucleus for the formation of St. Luke's Mission, which formally organized in 1881 and achieved parish status in 1884.
The General Convention of the Episcopal Church established the Missionary Jurisdiction of South Florida and the Rev. William Crane Gray was elected and consecrated its first bishop.  He made his home in Orlando and St. Luke's was designated as the Cathedral Church for South Florida on March 31, 1902.  The first cathedral dean was the Rev. Lucien A. Spencer.  It was decided that a new cathedral was needed and so the old church was moved in 1922 to make way for a new building.  The Boston architectural firm of Frohman, Robb, and Little, who designed the Washington National Cathedral, was chosen to design Orlando's new cathedral.
On April 13, 1925, the Rt. Rev. Cameron Mann laid the cornerstone and by 1926 the building was only partially constructed, but usable.  A financial depression was affecting Florida at the time and there was no money to complete it at that time so a temporary wall was constructed at the altar end of the church.  When the Very Rev. Charles T. Gaskell was dean from 1971 to 1973, the nave was renovated, the choir gallery was built over the narthex and an 88-rank pipe organ was installed.  In a construction project from 1986 to 1987, the temporary wall was removed and the cathedral was completed similar to its original plans when the Very Rev. Harry Sherman was dean. The completed cathedral includes an apse, ambulatory, priests and working sacristies, a bell tower and the St. Mary Chapel.
Cathedral Church of St. Luke (Orlando, Florida)