She served in the Mediterranean and later in the Eastern Fleet during the Second World War, from December 1944.
 Whilst serving in the Mediterranean, she sank the Italian sailing vessels Sant' Anna M. and Adelina, the Greek sailing vessel Aghios Konstantinos and two unidentified sailing vessels.
 She also sank the Italian submarine Velella, which was lost with all hands, and unsuccessfully attempted to torpedo what is identified as an Italian light cruiser.
 On transferral to the Far East, she sank the Japanese merchant cargo ship Unryu Maru.

She was damaged by gunfire and air attack in the Nankauri Strait, Andaman Islands on 3 January 1945, whilst engaged with the Japanese auxiliary minesweeper Wa 1.
 Both ships were damaged.
 Shakespeare returned to port, but was written off as a constructive total loss.

She was sold on 14 July 1946 and was broken up by Thos W Ward, of Briton Ferry.
She served in the Mediterranean and later in the Eastern Fleet during the Second World War, from December 1944.  Whilst serving in the Mediterranean, she sank the Italian sailing vessels Sant' Anna M. and Adelina, the Greek sailing vessel Aghios Konstantinos and two unidentified sailing vessels.  She also sank the Italian submarine Velella, which was lost with all hands, and unsuccessfully attempted to torpedo what is identified as an Italian light cruiser.  On transferral to the Far East, she sank the Japanese merchant cargo ship Unryu Maru.
She was damaged by gunfire and air attack in the Nankauri Strait, Andaman Islands on 3 January 1945, whilst engaged with the Japanese auxiliary minesweeper Wa 1.  Both ships were damaged.  Shakespeare returned to port, but was written off as a constructive total loss.
She was sold on 14 July 1946 and was broken up by Thos W Ward, of Briton Ferry.
HMS Shakespeare (P221)