Following the events of 11 September 2001, MALS-41 began participating in worldwide operations in support of the Global War on Terrorism (GWOT), Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Combined Joint Task Force - Horn of Africa (CJTF-HOA).
Many of the reserve Marines volunteered for activation in order to deploy or to augment the active duty in garrison for on-site support.

In late 2001, MALS-41 supported VMGR-234 as the reserve KC-130T squadron was activated and sustained combat flight operations in Afghanistan.
They continued direct flight operations for OEF based from Kuwait and operations for OIF out of Iraq.
The squadron and the MALS-41 augments returned from deployment in October 2003 and remained activated until late 2004.
Additionally, MALS-41 led and managed a KC-130 engine and propeller build shop from Sigonella, Italy, significantly reducing engine and prop turn around time.

In 2004, MALS-41 augmented VMFA-112 with 55 Marines when they were the first Reserve F/A-18 Hornet squadron to deploy on a Western Pacific exercise since the Korean War.
They supported Operation Jungle Shield and Exercise Southern Frontier while operating out of Japan, Guam, and Australia.

In 2005, the Wranglers again augmented VMFA-112 in support of Battle Griffin in Norway for multi-national exercises and NATO training in the United Kingdom.
Also, in 2005 Marines from MALS-41 were deployed with the reserve Hornet squadron from Atlanta, Georgia, for combat flight operations out of Al Asad, Iraq.
VMFA-142 was the first reserve Hornet Squadron activated for combat operations and MALS-41 answered the call to augment and deploy.
Following the events of 11 September 2001, MALS-41 began participating in worldwide operations in support of the Global War on Terrorism (GWOT), Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Combined Joint Task Force - Horn of Africa (CJTF-HOA). Many of the reserve Marines volunteered for activation in order to deploy or to augment the active duty in garrison for on-site support.
In late 2001, MALS-41 supported VMGR-234 as the reserve KC-130T squadron was activated and sustained combat flight operations in Afghanistan. They continued direct flight operations for OEF based from Kuwait and operations for OIF out of Iraq. The squadron and the MALS-41 augments returned from deployment in October 2003 and remained activated until late 2004. Additionally, MALS-41 led and managed a KC-130 engine and propeller build shop from Sigonella, Italy, significantly reducing engine and prop turn around time.
In 2004, MALS-41 augmented VMFA-112 with 55 Marines when they were the first Reserve F/A-18 Hornet squadron to deploy on a Western Pacific exercise since the Korean War. They supported Operation Jungle Shield and Exercise Southern Frontier while operating out of Japan, Guam, and Australia.
In 2005, the Wranglers again augmented VMFA-112 in support of Battle Griffin in Norway for multi-national exercises and NATO training in the United Kingdom. Also, in 2005 Marines from MALS-41 were deployed with the reserve Hornet squadron from Atlanta, Georgia, for combat flight operations out of Al Asad, Iraq. VMFA-142 was the first reserve Hornet Squadron activated for combat operations and MALS-41 answered the call to augment and deploy.
Marine Aviation Logistics Squadron 41