Meloni returned to his comedic roots when he portrayed the character Gene in Wet Hot American Summer in 2001, the puppet-loving pediatrician Dr. Norris in a 2003 episode of Scrubs, and the character of "Freakshow" (albeit in heavy make-up) in the 2004 comedy Harold & Kumar Go to White Castle.
He made another cameo in its sequel, Harold & Kumar Escape from Guantanamo Bay, as "The Grand Wizard".
In 2005, he appeared on episode 107 of MTV2's adult puppet show Wonder Showzen in a series of parody public service announcements warning of the threat of cooties.
He also had an uncredited role as a gay hotel desk clerk in Fear and Loathing In Las Vegas.

In July 2009, Meloni portrayed DC Comics character Hal Jordan/Green Lantern in the DC Universe Animated Original Movie Green Lantern: First Flight.
He briefly appeared in the first episode of the Comedy Central series Michael & Michael Have Issues portraying himself for a fake movie starring Michael Ian Black and Michael Showalter.

In 2012, Meloni joined the cast of True Blood during the series' fifth season as Roman, a "powerful, 500-year-old vampire who sits at the head of the table of the Vampire Authority."

Meloni played Colonel Hardy, a supporting role, in the Superman reboot film Man of Steel, which was released in 2013.
That year, he also played Brooklyn Dodgers manager Leo Durocher in the historical baseball feature 42.
He also starred in the 2014 comedy They Came Together.
He also stars as John Taylor in the video game Call of Duty: Black Ops III.

Meloni starred in and executive produced the Syfy series Happy!,
based on the comic book series created by writer Grant Morrison and artist Darick Robertson, which premiered in 2017.
The series was canceled on June 4, 2019.

In 2018, Meloni guest starred in two episodes of the FX drama series Pose, opposite Dominique Jackson.
He then appeared on the third season of The Handmaid's Tale as Commander Winslow in 2019.
Meloni returned to his comedic roots when he portrayed the character Gene in Wet Hot American Summer in 2001, the puppet-loving pediatrician Dr. Norris in a 2003 episode of Scrubs, and the character of "Freakshow" (albeit in heavy make-up) in the 2004 comedy Harold & Kumar Go to White Castle. He made another cameo in its sequel, Harold & Kumar Escape from Guantanamo Bay, as "The Grand Wizard". In 2005, he appeared on episode 107 of MTV2's adult puppet show Wonder Showzen in a series of parody public service announcements warning of the threat of cooties. He also had an uncredited role as a gay hotel desk clerk in Fear and Loathing In Las Vegas.
In July 2009, Meloni portrayed DC Comics character Hal Jordan/Green Lantern in the DC Universe Animated Original Movie Green Lantern: First Flight. He briefly appeared in the first episode of the Comedy Central series Michael & Michael Have Issues portraying himself for a fake movie starring Michael Ian Black and Michael Showalter.
In 2012, Meloni joined the cast of True Blood during the series' fifth season as Roman, a "powerful, 500-year-old vampire who sits at the head of the table of the Vampire Authority."
Meloni played Colonel Hardy, a supporting role, in the Superman reboot film Man of Steel, which was released in 2013. That year, he also played Brooklyn Dodgers manager Leo Durocher in the historical baseball feature 42. He also starred in the 2014 comedy They Came Together. He also stars as John Taylor in the video game Call of Duty: Black Ops III.
Meloni starred in and executive produced the Syfy series Happy!, based on the comic book series created by writer Grant Morrison and artist Darick Robertson, which premiered in 2017. The series was canceled on June 4, 2019.
In 2018, Meloni guest starred in two episodes of the FX drama series Pose, opposite Dominique Jackson. He then appeared on the third season of The Handmaid's Tale as Commander Winslow in 2019.
Christopher Meloni