The city was founded by Diego Velázquez de Cuéllar in 1514.

The city contributed men for Hernan Cortes' 1518 expedition to Mexico, including Alonso Hernandez Puertocarrero, Gonzalo de Sandoval, and Juan Velazquez de Leon.

Francisco Iznaga, a Basque landowner in the western portion of Cuba during the first thirty years of the colonization of Cuba, was elected mayor of Bayamo in 1540.
Iznaga was the originator of a powerful lineage which finally settled in Sancti Spíritus and Trinidad, where Torre Iznaga (Iznaga Tower) is.
His descendants fought for the independence of Cuba and for annexation to the U.S., from 1820 to 1900.
The city was founded by Diego Velázquez de Cuéllar in 1514.
The city contributed men for Hernan Cortes' 1518 expedition to Mexico, including Alonso Hernandez Puertocarrero, Gonzalo de Sandoval, and Juan Velazquez de Leon.
Francisco Iznaga, a Basque landowner in the western portion of Cuba during the first thirty years of the colonization of Cuba, was elected mayor of Bayamo in 1540. Iznaga was the originator of a powerful lineage which finally settled in Sancti Spíritus and Trinidad, where Torre Iznaga (Iznaga Tower) is. His descendants fought for the independence of Cuba and for annexation to the U.S., from 1820 to 1900.
Sancti Spíritus