The stadium hosted the first three editions (2004–06) of the USA Sevens, an annual international rugby sevens competition that is part of the World Rugby Sevens Series, and will again host that event on February 29 to March 1, 2020.
The stadium has also hosted all United States national team matches for the Pacific Nations Cup since 2013.

It was also the location for the State Championship Bowl Games for high school football teams in the state of California from 2006 to 2014.
The Semper Fidelis All America game was held there on January 5, 2014, featuring an East vs West high school matchup.
The first college football game was held at the stadium on January 21, 2012, as the AstroTurf NFLPA Collegiate Bowl, with the National Team beating the American Team 20–14.

The track played host to the 2005 USA Outdoor Track and Field Championships.
It is also the home of the Adidas Running Club, a member of the USA Elite Running Circuit, and the Adidas Track Classic.
Dignity Health Sports Park is also home to  EXOS, formerly Athletes' Performance, which trains athletes in a variety of sports.

The Los Angeles Riptide of Major League Lacrosse played their home games at the track and field stadium.

The soccer and tennis stadiums of the Center have also served as the main venues for ESPN's Summer X Games.

From 2010 to 2016, it hosted the Reebok CrossFit Games.
Initially only utilizing the tennis stadium, over the years it also expanded to the running field and the soccer stadium.

The facility has also hosted several high-profile professional boxing matches, including Andre Ward vs. Arthur Abraham, Brandon Ríos vs. Urbano Antillón, Shawn Porter vs. Kell Brook and matches featuring other notable fighters.
The venue has become iconic among boxing fans for its electric atmosphere.

On August 16, 2013, Resurrection Fighting Alliance held an MMA event RFA 9: Curran vs. Munhoz with the main event crowning a new Bantamweight Champion.
The stadium hosted the first three editions (2004–06) of the USA Sevens, an annual international rugby sevens competition that is part of the World Rugby Sevens Series, and will again host that event on February 29 to March 1, 2020. The stadium has also hosted all United States national team matches for the Pacific Nations Cup since 2013.
It was also the location for the State Championship Bowl Games for high school football teams in the state of California from 2006 to 2014. The Semper Fidelis All America game was held there on January 5, 2014, featuring an East vs West high school matchup. The first college football game was held at the stadium on January 21, 2012, as the AstroTurf NFLPA Collegiate Bowl, with the National Team beating the American Team 20–14.
The track played host to the 2005 USA Outdoor Track and Field Championships. It is also the home of the Adidas Running Club, a member of the USA Elite Running Circuit, and the Adidas Track Classic. Dignity Health Sports Park is also home to  EXOS, formerly Athletes' Performance, which trains athletes in a variety of sports.
The Los Angeles Riptide of Major League Lacrosse played their home games at the track and field stadium.
The soccer and tennis stadiums of the Center have also served as the main venues for ESPN's Summer X Games.
From 2010 to 2016, it hosted the Reebok CrossFit Games. Initially only utilizing the tennis stadium, over the years it also expanded to the running field and the soccer stadium.
The facility has also hosted several high-profile professional boxing matches, including Andre Ward vs. Arthur Abraham, Brandon Ríos vs. Urbano Antillón, Shawn Porter vs. Kell Brook and matches featuring other notable fighters. The venue has become iconic among boxing fans for its electric atmosphere.
On August 16, 2013, Resurrection Fighting Alliance held an MMA event RFA 9: Curran vs. Munhoz with the main event crowning a new Bantamweight Champion.
Dignity Health Sports Park