In 1995, DeWitt, with Stephen and Frederick Brauer, purchased the St. Louis Cardinals from Anheuser-Busch for $150 million.
 He oversees all league, financial, operational and baseball affairs for the club.
 Since DeWitt bought the team, the Cardinals have won two World Series (2006 and 2011), four National League pennants, and eight division titles, and have made 11 total playoff appearances.
Forbes estimated that the team was worth $1.4 billion in 2014 and $2.1 billion in July 2019.
 The Cardinals are one of the largest privately held firms in St. Louis, bringing in an estimated $233 million in revenue in 2012.

In 1997, DeWitt established Cardinals Care, a nonprofit organization that builds baseball fields, helps youth baseball programs, and awards grants to children's boards.
Through January 2017, Cardinals Care had distributed some $900,000 a year.
As of 2013, the organization has built 18 baseball fields in the Greater St. Louis area.
Since 2004, the organization has run Redbird Rookies, a network of 20 leagues for nearly 4,500 children around Greater St. Louis and in rural sections of Missouri and Illinois.
who would not otherwise have the opportunity.
It provides equipment and other necessities to the players, training for coaches and organizers, and workshops for parents.
 
The Cardinals have purchased three of their minor league affiliates since the DeWitt group took over.
In 1998, DeWitt purchased the Palm Beach Cardinals of the Florida State League (minor league A-ball) and, in 2005, the Springfield Cardinals of the Texas League (AA).
As of April 2013, the team negotiated to purchase the Memphis Redbirds of the Pacific Coast League (AAA) from the Memphis Redbirds Foundation (MRF), a local non-profit entity.
 However, talks went on hold due to defaulted bonds on the building of AutoZone Park.
On November 16, 2013, the Cardinals announced a resolution to purchase the team while the city purchased the stadium.
The Cardinals agreed to lease the stadium from the city while Memphis will upgrade the park.
 In 2013, Forbes listed the Redbirds as one of the ten most valuable minor league franchises.

To expand the Cardinals' international presence, DeWitt opened baseball academies in the Dominican Republic and placed representatives in six foreign countries.

In 2006, the Cardinals moved from their old home, Busch Memorial Stadium, to Busch Stadium in 2006.
 The $365 million stadium is one of the few majority-privately funded MLB stadiums, along with the San Francisco Giants' Oracle Park and the Los Angeles Dodgers' Dodger Stadium.
Busch Stadium cost $45 million (12%) in a long-term loan from St. Louis County, while, by comparison the Milwaukee Brewers' Miller Park ended up drawing 77.5% in public funding.

In conjunction with opening the new Busch Stadium, a mixed-use retail, entertainment, hotel, residential and office space known as Ballpark Village was planned for development adjacent to Busch Stadium.
However, several years of delays postponed the groundbreaking and construction until spring of 2013.

In 2009, the Cardinals hosted the All-Star Game.

DeWitt began emphasizing developing talent as much as possible through the minor leagues, rather than relying mainly on free agents.
 Seventeen of the 25 players on the Cardinals' 2011 World Series roster were Cardinals' draftees.

In January 2014, the city of Memphis cleared the Cardinals to purchase the Memphis Redbirds from the MRF.
 Ballpark Village construction was completed and it opened in March 2014.
 The Cardinals also announced the rechristening of the team Hall of Fame Museum with an annual selection process selection commencing in 2015.
Twenty-two former Cardinals players and personnel were announced for induction into the Hall of Fame for the inaugural class of 2014.
Closed since 2008 when the International Bowling Hall of Fame moved to Texas, this reincarnation of the museum is located in the newly constructed Ballpark Village within the same building as the Cardinal Nation Restaurant.

The Cardinals' value exceeded $1 billion for the first time in 2015 when Fo
In 1995, DeWitt, with Stephen and Frederick Brauer, purchased the St. Louis Cardinals from Anheuser-Busch for $150 million.  He oversees all league, financial, operational and baseball affairs for the club.  Since DeWitt bought the team, the Cardinals have won two World Series (2006 and 2011), four National League pennants, and eight division titles, and have made 11 total playoff appearances. Forbes estimated that the team was worth $1.4 billion in 2014 and $2.1 billion in July 2019.  The Cardinals are one of the largest privately held firms in St. Louis, bringing in an estimated $233 million in revenue in 2012.
In 1997, DeWitt established Cardinals Care, a nonprofit organization that builds baseball fields, helps youth baseball programs, and awards grants to children's boards. Through January 2017, Cardinals Care had distributed some $900,000 a year. As of 2013, the organization has built 18 baseball fields in the Greater St. Louis area. Since 2004, the organization has run Redbird Rookies, a network of 20 leagues for nearly 4,500 children around Greater St. Louis and in rural sections of Missouri and Illinois. who would not otherwise have the opportunity. It provides equipment and other necessities to the players, training for coaches and organizers, and workshops for parents.  
The Cardinals have purchased three of their minor league affiliates since the DeWitt group took over. In 1998, DeWitt purchased the Palm Beach Cardinals of the Florida State League (minor league A-ball) and, in 2005, the Springfield Cardinals of the Texas League (AA). As of April 2013, the team negotiated to purchase the Memphis Redbirds of the Pacific Coast League (AAA) from the Memphis Redbirds Foundation (MRF), a local non-profit entity.  However, talks went on hold due to defaulted bonds on the building of AutoZone Park. On November 16, 2013, the Cardinals announced a resolution to purchase the team while the city purchased the stadium. The Cardinals agreed to lease the stadium from the city while Memphis will upgrade the park.  In 2013, Forbes listed the Redbirds as one of the ten most valuable minor league franchises.
To expand the Cardinals' international presence, DeWitt opened baseball academies in the Dominican Republic and placed representatives in six foreign countries.
In 2006, the Cardinals moved from their old home, Busch Memorial Stadium, to Busch Stadium in 2006.  The $365 million stadium is one of the few majority-privately funded MLB stadiums, along with the San Francisco Giants' Oracle Park and the Los Angeles Dodgers' Dodger Stadium. Busch Stadium cost $45 million (12%) in a long-term loan from St. Louis County, while, by comparison the Milwaukee Brewers' Miller Park ended up drawing 77.5% in public funding.
In conjunction with opening the new Busch Stadium, a mixed-use retail, entertainment, hotel, residential and office space known as Ballpark Village was planned for development adjacent to Busch Stadium. However, several years of delays postponed the groundbreaking and construction until spring of 2013.
In 2009, the Cardinals hosted the All-Star Game.
DeWitt began emphasizing developing talent as much as possible through the minor leagues, rather than relying mainly on free agents.  Seventeen of the 25 players on the Cardinals' 2011 World Series roster were Cardinals' draftees.
In January 2014, the city of Memphis cleared the Cardinals to purchase the Memphis Redbirds from the MRF.  Ballpark Village construction was completed and it opened in March 2014.  The Cardinals also announced the rechristening of the team Hall of Fame Museum with an annual selection process selection commencing in 2015. Twenty-two former Cardinals players and personnel were announced for induction into the Hall of Fame for the inaugural class of 2014. Closed since 2008 when the International Bowling Hall of Fame moved to Texas, this reincarnation of the museum is located in the newly constructed Ballpark Village within the same building as the Cardinal Nation Restaurant.
The Cardinals' value exceeded $1 billion for the first time in 2015 when Fo
William DeWitt Jr.