On January 14, 2015, Orgeron was hired as the defensive line coach at Louisiana State University (LSU).

On September 25, 2016, after LSU head coach Les Miles was fired following a loss to Auburn, Orgeron was named the team's interim head coach.

Orgeron stated that he was going to "flip the script".
He promoted tight ends coach Steve Ensminger to offensive coordinator and brought back Pete Jenkins to take over  as defensive line coach.
Orgeron also decided to shorten practices and spend more time in the film room in order to keep players fresh.
In addition, he brought the "theme of daily practices" he modeled from coach Pete Carroll during Orgeron's first stint as an assistant at USC.
These practice days have descriptive nicknames like Tell the Truth Monday, Competition Tuesday, Turnover Wednesday, No Repeat Thursday, and Focus Friday.

Under Orgeron's watch, LSU finished out the season with a 6–2 record.
On November 26, 2016, LSU removed the "interim" tag from Orgeron's title and formally named him as its 32nd full-time head coach.

The beginning of the 2017 season saw Orgeron hire Matt Canada to be the offensive coordinator.
Canada was known for an offensive playbook that was heavily based on setting skilled positions in motion prior to the snap, thus using jet sweeps often.
The season began with LSU ranked in the top 15, but early losses to Mississippi State and Troy quickly found LSU unranked.
However, the team went 7–2 in their remaining games, finishing the year with a 9–4 record.

The 2018 season began with a season opening upset of 8th-ranked Miami, followed by another upset of 7th-ranked Auburn.
These victories helped LSU rise to 5th in the CFP rankings, but a loss to 25th-ranked Florida sent LSU tumbling back to 13th.
In response, the Tigers pulled off a shocking upset of #2 Georgia followed by avenging the previous year's loss to Mississippi State.
The victories over Georgia and Mississippi State propelled LSU to being ranked #3 by the CFP going into a game against top-ranked Alabama.
The LSU offense that had seemed to turn around after Steve Ensminger took over the duties of offensive coordinator was unable to score against Alabama's defense.
After the loss to Alabama, LSU was able to defeat Arkansas and Rice before falling to Texas A&M in a 7-overtime game.
With a 9–3 record, LSU was invited to the Fiesta Bowl to play the University of Central Florida, who had not lost a game in the previous two seasons.
On New Years Day 2019, LSU gave UCF their first loss since 2016.
LSU finished the 2018 season with a record of 10–3 and were ranked sixth in the nation by the AP poll and seventh by the Coaches poll.
LSU was not predicted to have a good season in 2018, and some, including respected SEC commentator Paul Finebaum, believed it would be Orgeron's last.
However, the successful season earned Orgeron a contract extension through the 2022 season.

After opening with a home win versus Georgia Southern, Orgeron's 2019 team recorded a statement road win over Texas in week two and proceeded to go undefeated through the regular season, including a 46–41 victory over Alabama at Bryant-Denny Stadium in Tuscaloosa.
A win over Arkansas in the penultimate game of the regular season clinched the SEC West division title and secured a berth in the 2019 SEC Championship Game against Georgia.
This was their first appearance in the SEC Championship Game since 2011.
The traditionally defensive-minded Tigers averaged over 48 points per game, led by quarterback Joe Burrow and Baton Rouge-native running back Clyde Edwards-Helaire.
Burrow set new LSU and SEC single-season records for passing yards with 4,366; his 44 touchdown passes set a new LSU record and tied the SEC mark.
Orgeron's Tigers defeated the Georgia Bulldogs in the SEC Championship Game to win their first SEC title since 2011.
On Sunday, December 8, 2019, they were named the No.
1 seed in the College Football Playoff.
They met the Big 12 Conference champion Oklahoma Sooners in the semifinals in the Peach Bowl, defeating them by a score of 63–28.

Following the regular season, O
On January 14, 2015, Orgeron was hired as the defensive line coach at Louisiana State University (LSU).
On September 25, 2016, after LSU head coach Les Miles was fired following a loss to Auburn, Orgeron was named the team's interim head coach.
Orgeron stated that he was going to "flip the script". He promoted tight ends coach Steve Ensminger to offensive coordinator and brought back Pete Jenkins to take over  as defensive line coach. Orgeron also decided to shorten practices and spend more time in the film room in order to keep players fresh. In addition, he brought the "theme of daily practices" he modeled from coach Pete Carroll during Orgeron's first stint as an assistant at USC. These practice days have descriptive nicknames like Tell the Truth Monday, Competition Tuesday, Turnover Wednesday, No Repeat Thursday, and Focus Friday.
Under Orgeron's watch, LSU finished out the season with a 6–2 record. On November 26, 2016, LSU removed the "interim" tag from Orgeron's title and formally named him as its 32nd full-time head coach.
The beginning of the 2017 season saw Orgeron hire Matt Canada to be the offensive coordinator. Canada was known for an offensive playbook that was heavily based on setting skilled positions in motion prior to the snap, thus using jet sweeps often. The season began with LSU ranked in the top 15, but early losses to Mississippi State and Troy quickly found LSU unranked. However, the team went 7–2 in their remaining games, finishing the year with a 9–4 record.
The 2018 season began with a season opening upset of 8th-ranked Miami, followed by another upset of 7th-ranked Auburn. These victories helped LSU rise to 5th in the CFP rankings, but a loss to 25th-ranked Florida sent LSU tumbling back to 13th. In response, the Tigers pulled off a shocking upset of #2 Georgia followed by avenging the previous year's loss to Mississippi State. The victories over Georgia and Mississippi State propelled LSU to being ranked #3 by the CFP going into a game against top-ranked Alabama. The LSU offense that had seemed to turn around after Steve Ensminger took over the duties of offensive coordinator was unable to score against Alabama's defense. After the loss to Alabama, LSU was able to defeat Arkansas and Rice before falling to Texas A&M in a 7-overtime game. With a 9–3 record, LSU was invited to the Fiesta Bowl to play the University of Central Florida, who had not lost a game in the previous two seasons. On New Years Day 2019, LSU gave UCF their first loss since 2016. LSU finished the 2018 season with a record of 10–3 and were ranked sixth in the nation by the AP poll and seventh by the Coaches poll. LSU was not predicted to have a good season in 2018, and some, including respected SEC commentator Paul Finebaum, believed it would be Orgeron's last. However, the successful season earned Orgeron a contract extension through the 2022 season.
After opening with a home win versus Georgia Southern, Orgeron's 2019 team recorded a statement road win over Texas in week two and proceeded to go undefeated through the regular season, including a 46–41 victory over Alabama at Bryant-Denny Stadium in Tuscaloosa. A win over Arkansas in the penultimate game of the regular season clinched the SEC West division title and secured a berth in the 2019 SEC Championship Game against Georgia. This was their first appearance in the SEC Championship Game since 2011. The traditionally defensive-minded Tigers averaged over 48 points per game, led by quarterback Joe Burrow and Baton Rouge-native running back Clyde Edwards-Helaire. Burrow set new LSU and SEC single-season records for passing yards with 4,366; his 44 touchdown passes set a new LSU record and tied the SEC mark. Orgeron's Tigers defeated the Georgia Bulldogs in the SEC Championship Game to win their first SEC title since 2011. On Sunday, December 8, 2019, they were named the No. 1 seed in the College Football Playoff. They met the Big 12 Conference champion Oklahoma Sooners in the semifinals in the Peach Bowl, defeating them by a score of 63–28. 
Following the regular season, O
Ed Orgeron