In her first match of the year, Razzano was defeated by Barbora Záhlavová-Strýcová in the first round in Auckland.
At the Moorilla Hobart International, Razzano reached the semifinal where she lost to Petra Kvitová.
Ranked fifty-six at the Australian Open, Razzano beat Jarmila Gajdošová and fourteenth seeded Patty Schnyder en route to the third round, where she lost to eighteenth seed Dominika Cibulková.

Razzano fell in the first round of the Open GDF Suez to Anastasia Pavlyuchenkova.
However, she rebounded at the Dubai Tennis Championships.
She advanced to the final after victories over Kateryna Bondarenko, second seed Dinara Safina, Daniela Hantuchová, fifth seed Vera Zvonareva, and sixteenth seed Kaia Kanepi.
She was defeated in the final by sixth seed Venus Williams.

In March, Razzano competed at the BNP Paribas Open in Indian Wells.
After beating Evgeniya Rodina in her first-round match, she was forced to retire during her second-round match against eighteenth seed Kaia Kanepi due to a back injury.
Razzano fell in the first round of the Sony Ericsson Open to qualifier Julia Görges.

At Ponte Vedra Beach, Razzano defeated Akgul Amanmuradova in the first round, but lost in the second round to second seed and eventual champion Caroline Wozniacki.
Razzano reached the quarterfinals of Charleston as the 13th seed, but lost again to Wozniacki, again in straight sets.
She was defeated in the second round of the Internazionali BNL d'Italia by world No.
1 and eventual champion Dinara Safina.
She lost to Elena Vesnina in the second round of Madrid.

At the French Open, Razzano was unseeded and defeated former world No.
5 Daniela Hantuchová in the first round.
She then thrashed 18th seed Anabel Medina Garrigues in two sets, in the second round and beat Tathiana Garbin in the third round in two tight sets.
She lost in the fourth round to 30th seed Samantha Stosur.
As a result of these wins, Razzano's ranking improved to world No.
26.

After withdrawing from a tournament in Birmingham with a lower back injury, Razzano entered the tournament in Eastbourne, where she was unseeded.
She defeated fellow Frenchwoman Alizé Cornet in the first round.
She then beat the top seed and world No.
4 Elena Dementieva, winning the decisive third-set tiebreak.
She followed this win up with a win over eighth seed and defending champion Agnieszka Radwańska in the quarterfinals.
In the semifinals, she was up 6–4, 1–0 when Marion Bartoli was forced to retire with a right quad strain.
She lost in the final to sixth seed Caroline Wozniacki.
However, Razzano's ranking improved to world No.
23.

At Wimbledon, Razzano was seeded 26th.
In the first round, her opponent Tamira Paszek retired after falling behind 6–0, 3–1.
After a win over Jill Craybas in the second round, her third-round opponent Vera Zvonareva withdrew to allow Razzano to her first Wimbledon fourth round.
Razzano then fell, 2–6, 6–7, to Francesca Schiavone in the fourth round.
Despite this loss, Razzano reached a new career-high ranking of world No.
17.

Razzano started her US Open Series campaign in Los Angeles, where she was seeded 11th.
She lost in the first round to Anna Chakvetadze.
She was seeded 16th at Cincinnati, but also lost in the first round to Anna-Lena Grönefeld.
Razzano played her last tournament before the US Open in New Haven.
Unseeded in singles, she defeated world No.
20 Patty Schnyder in three sets, in the first round.
Fifth seed Agnieszka Radwańska had to retire due to injury in the second round with the score at one set all.
Razzano was defeated by Caroline Wozniacki in the quarterfinals.
Razzano was seeded 16th at the US Open, but suffered a surprise defeat in the first round to eventual semifinalist Yanina Wickmayer.

Razzano continued her disappointing end to the season in Tokyo as the 16th seed, losing to Iveta Benešová, in the first round.
She was forced to pull out of the China Open due to a left calf strain.
This turned out to be the end of Razzano's season.
She finished her best season on tour ranked world No.
19.
In her first match of the year, Razzano was defeated by Barbora Záhlavová-Strýcová in the first round in Auckland. At the Moorilla Hobart International, Razzano reached the semifinal where she lost to Petra Kvitová. Ranked fifty-six at the Australian Open, Razzano beat Jarmila Gajdošová and fourteenth seeded Patty Schnyder en route to the third round, where she lost to eighteenth seed Dominika Cibulková.
Razzano fell in the first round of the Open GDF Suez to Anastasia Pavlyuchenkova. However, she rebounded at the Dubai Tennis Championships. She advanced to the final after victories over Kateryna Bondarenko, second seed Dinara Safina, Daniela Hantuchová, fifth seed Vera Zvonareva, and sixteenth seed Kaia Kanepi. She was defeated in the final by sixth seed Venus Williams.
In March, Razzano competed at the BNP Paribas Open in Indian Wells. After beating Evgeniya Rodina in her first-round match, she was forced to retire during her second-round match against eighteenth seed Kaia Kanepi due to a back injury. Razzano fell in the first round of the Sony Ericsson Open to qualifier Julia Görges.
At Ponte Vedra Beach, Razzano defeated Akgul Amanmuradova in the first round, but lost in the second round to second seed and eventual champion Caroline Wozniacki. Razzano reached the quarterfinals of Charleston as the 13th seed, but lost again to Wozniacki, again in straight sets. She was defeated in the second round of the Internazionali BNL d'Italia by world No. 1 and eventual champion Dinara Safina. She lost to Elena Vesnina in the second round of Madrid.
At the French Open, Razzano was unseeded and defeated former world No. 5 Daniela Hantuchová in the first round. She then thrashed 18th seed Anabel Medina Garrigues in two sets, in the second round and beat Tathiana Garbin in the third round in two tight sets. She lost in the fourth round to 30th seed Samantha Stosur. As a result of these wins, Razzano's ranking improved to world No. 26.
After withdrawing from a tournament in Birmingham with a lower back injury, Razzano entered the tournament in Eastbourne, where she was unseeded. She defeated fellow Frenchwoman Alizé Cornet in the first round. She then beat the top seed and world No. 4 Elena Dementieva, winning the decisive third-set tiebreak. She followed this win up with a win over eighth seed and defending champion Agnieszka Radwańska in the quarterfinals. In the semifinals, she was up 6–4, 1–0 when Marion Bartoli was forced to retire with a right quad strain. She lost in the final to sixth seed Caroline Wozniacki. However, Razzano's ranking improved to world No. 23.
At Wimbledon, Razzano was seeded 26th. In the first round, her opponent Tamira Paszek retired after falling behind 6–0, 3–1. After a win over Jill Craybas in the second round, her third-round opponent Vera Zvonareva withdrew to allow Razzano to her first Wimbledon fourth round. Razzano then fell, 2–6, 6–7, to Francesca Schiavone in the fourth round. Despite this loss, Razzano reached a new career-high ranking of world No. 17.
Razzano started her US Open Series campaign in Los Angeles, where she was seeded 11th. She lost in the first round to Anna Chakvetadze. She was seeded 16th at Cincinnati, but also lost in the first round to Anna-Lena Grönefeld. Razzano played her last tournament before the US Open in New Haven. Unseeded in singles, she defeated world No. 20 Patty Schnyder in three sets, in the first round. Fifth seed Agnieszka Radwańska had to retire due to injury in the second round with the score at one set all. Razzano was defeated by Caroline Wozniacki in the quarterfinals. Razzano was seeded 16th at the US Open, but suffered a surprise defeat in the first round to eventual semifinalist Yanina Wickmayer.
Razzano continued her disappointing end to the season in Tokyo as the 16th seed, losing to Iveta Benešová, in the first round. She was forced to pull out of the China Open due to a left calf strain. This turned out to be the end of Razzano's season. She finished her best season on tour ranked world No. 19.
Virginie Razzano