Fowler began the 2010–11 season on the Ducks' opening night lineup.
He scored his first career NHL goal on October 17 against Phoenix Coyotes' goaltender Jason LaBarbera in a 3–2 win.
Fowler was selected to the 2011 NHL All-Star Game as part of the rookie class.
Fowler ended the season with ten goals and 40 points in 76 games.

Entering the final year of his entry-level contract, the Ducks signed Fowler to a five-year, $20 million contract extension on September 12, 2012.
For the duration of the 2012–13 NHL lockout, Fowler played for Södertälje SK in Sweden.
He re-joined the Ducks once the season began.
In the shortened-season, he had one goal and 10 assists in 37 games.
Fowler made his Stanley Cup playoff debut that spring.
He and the Ducks lost in seven games to the Detroit Red Wings during the Western Conference Quarterfinals.
Fowler had three assists.

On July 1, 2017, the Ducks signed Fowler to an eight-year, $52 million contract extension.

On November 4, 2018, Fowler scored his first career hat-trick in a 3–2 overtime win against the Columbus Blue Jackets.
On November 12, in a game against the Nashville Predators, Fowler was hit in the face by the puck causing a fracture in his face.
He was subsequently placed on injured reserve two days later as he required a surgery to repair the facial fracture.
Fowler began the 2010–11 season on the Ducks' opening night lineup. He scored his first career NHL goal on October 17 against Phoenix Coyotes' goaltender Jason LaBarbera in a 3–2 win. Fowler was selected to the 2011 NHL All-Star Game as part of the rookie class. Fowler ended the season with ten goals and 40 points in 76 games.
Entering the final year of his entry-level contract, the Ducks signed Fowler to a five-year, $20 million contract extension on September 12, 2012. For the duration of the 2012–13 NHL lockout, Fowler played for Södertälje SK in Sweden. He re-joined the Ducks once the season began. In the shortened-season, he had one goal and 10 assists in 37 games. Fowler made his Stanley Cup playoff debut that spring. He and the Ducks lost in seven games to the Detroit Red Wings during the Western Conference Quarterfinals. Fowler had three assists.
On July 1, 2017, the Ducks signed Fowler to an eight-year, $52 million contract extension.
On November 4, 2018, Fowler scored his first career hat-trick in a 3–2 overtime win against the Columbus Blue Jackets. On November 12, in a game against the Nashville Predators, Fowler was hit in the face by the puck causing a fracture in his face. He was subsequently placed on injured reserve two days later as he required a surgery to repair the facial fracture.
Cam Fowler