In 1500–01, the conflict between Khanzada's brother, Babur, and the Uzbeks was at its most intense.
For six months, Shaybani Khan Uzbek besieged Babur in Samarkand.
None of Khanzada and Babur's powerful relatives, such as their paternal uncle, Sultan Husayn Mirza Bayqara, the ruler of Greater Khorasan, sent Babur help.
At this time, Shaybani Khan sent a message to Babur, proposing that if Babur would marry his sister Khanzada Begum to him, there would be a lasting alliance between them.
According to Khanzada's niece, Gulbadan Begum, "at length it had to be done, he gave the Begum to the Khan, and came out himself (from Samarkand) ... in this plight, unarmed, and relying on God, he went towards the land of Badakshan... and Kabul."

According to the Baburnama in 1500, Khanzada's brother Babur had to abandon Samarkand, after a five-month siege by Muhammad Shaybani Khan, at this time Khanzada fell to Shaybani Khan (as his share of the war captives).
According to the Akbarnama, Henry Beveridge, writes that according to the Shaybani-nama, Khanzada's marriage with Shaybani Khan was a love-match.
He also suggests the probability that "Babur has not mentioned the whole of the circumstances and that her [Khanzada] being left behind was a part of Babur's agreement with Shaybani."

In July 1500, Khanzada's maternal aunt, Mihr Nigar Khanum, had been captured by Shaybani Khan and forcibly married to him, 'as part of the spoils'.
She was divorced when Shaybani resolved to marry her Timurid niece, Khanzada Begum, as it is unlawful in Islam for both aunt and niece to be wedded to the same man.

After their marriage, Khanzada and Shaybani had one child together, a son, Khurram, who died in his childhood.
Shaybani later divorced Khanzada because she leaned towards her brother's side in disputed matters.
In 1500–01, the conflict between Khanzada's brother, Babur, and the Uzbeks was at its most intense. For six months, Shaybani Khan Uzbek besieged Babur in Samarkand. None of Khanzada and Babur's powerful relatives, such as their paternal uncle, Sultan Husayn Mirza Bayqara, the ruler of Greater Khorasan, sent Babur help. At this time, Shaybani Khan sent a message to Babur, proposing that if Babur would marry his sister Khanzada Begum to him, there would be a lasting alliance between them. According to Khanzada's niece, Gulbadan Begum, "at length it had to be done, he gave the Begum to the Khan, and came out himself (from Samarkand) ... in this plight, unarmed, and relying on God, he went towards the land of Badakshan... and Kabul."
According to the Baburnama in 1500, Khanzada's brother Babur had to abandon Samarkand, after a five-month siege by Muhammad Shaybani Khan, at this time Khanzada fell to Shaybani Khan (as his share of the war captives). According to the Akbarnama, Henry Beveridge, writes that according to the Shaybani-nama, Khanzada's marriage with Shaybani Khan was a love-match. He also suggests the probability that "Babur has not mentioned the whole of the circumstances and that her [Khanzada] being left behind was a part of Babur's agreement with Shaybani." 
In July 1500, Khanzada's maternal aunt, Mihr Nigar Khanum, had been captured by Shaybani Khan and forcibly married to him, 'as part of the spoils'. She was divorced when Shaybani resolved to marry her Timurid niece, Khanzada Begum, as it is unlawful in Islam for both aunt and niece to be wedded to the same man.
After their marriage, Khanzada and Shaybani had one child together, a son, Khurram, who died in his childhood. Shaybani later divorced Khanzada because she leaned towards her brother's side in disputed matters.
Khanzada Begum