The street has buildings of mainly five to eight storeys with a strong residential presence.
Notable residents who lived for a time in the street include the Pre-Raphaelite artist and poet Dante Gabriel Rossetti (1828–1882), the painters John Sell Cotman (1782-1842), Cornelius Varley (1781-1873), Sir Peter Francis Bourgeois(1753–1811), dominatrix Theresa Berkley (d.1836), the writer William Gerhardi (1895–1977), the conductor and founder of The Proms Sir Henry Joseph Wood (1869–1944), American journalist and broadcaster Edward R Murrow (1908–1965), World War Two hero Wing Commander Forest Frederick Edward Yeo-Thomas (1901–1964), the radio and television writer Ernest Dudley (1908–2006), and the Austrian writer Stefan Zweig (1881–1942).

Number 50 Charlotte Street (later renamed 93 Hallam Street) was both the home and official residence from 1875 to 1910 of Jesse Claxton who was the Registrar of Births and Deaths for St Marylebone for 35 years.

Numbers 44 and 50 Hallam Street, originally the offices of the General Medical Council, received Grade II designation in 1954.
A large number of the street’s buildings have been characterised as "unlisted buildings of merit" in the Harley Street Conservation Area Audit and are either part of the Howard de Walden Estate (originally the Portland Estate) or the Langham Estate (also once part of the Howard de Walden Estate).

Hallam Street contains a number of institutional buildings (including the BBC’s Broadcasting House) from the Edwardian and inter-war periods.
Blitz bomb damage was extensive at the south end of the street, its synagogue was also destroyed while other buildings experienced blast damage.
The street has buildings of mainly five to eight storeys with a strong residential presence. Notable residents who lived for a time in the street include the Pre-Raphaelite artist and poet Dante Gabriel Rossetti (1828–1882), the painters John Sell Cotman (1782-1842), Cornelius Varley (1781-1873), Sir Peter Francis Bourgeois(1753–1811), dominatrix Theresa Berkley (d.1836), the writer William Gerhardi (1895–1977), the conductor and founder of The Proms Sir Henry Joseph Wood (1869–1944), American journalist and broadcaster Edward R Murrow (1908–1965), World War Two hero Wing Commander Forest Frederick Edward Yeo-Thomas (1901–1964), the radio and television writer Ernest Dudley (1908–2006), and the Austrian writer Stefan Zweig (1881–1942).
Number 50 Charlotte Street (later renamed 93 Hallam Street) was both the home and official residence from 1875 to 1910 of Jesse Claxton who was the Registrar of Births and Deaths for St Marylebone for 35 years.
Numbers 44 and 50 Hallam Street, originally the offices of the General Medical Council, received Grade II designation in 1954. A large number of the street’s buildings have been characterised as "unlisted buildings of merit" in the Harley Street Conservation Area Audit and are either part of the Howard de Walden Estate (originally the Portland Estate) or the Langham Estate (also once part of the Howard de Walden Estate).
Hallam Street contains a number of institutional buildings (including the BBC’s Broadcasting House) from the Edwardian and inter-war periods. Blitz bomb damage was extensive at the south end of the street, its synagogue was also destroyed while other buildings experienced blast damage.
Hallam Street