In December 2009, Chatwin was filming the Showtime pilot Shameless, an adaptation of Paul Abbott's British series, starring opposite William H. Macy and Emmy Rossum (with whom he also starred in 2009's Dragonball Evolution).
In April 2010, the network green-lit the show with a 12-episode order.
During the course of three years, he was a series regular, playing Jimmy Lishman / Steve Wilton, Rossum's love interest.
Chatwin returned in the fourth season finale, and appeared in the fifth season as a special guest star in the 6th and 7th episodes.
The series received mostly positive reviews from critics.
Chatwin was complimented for bringing "the right vibe of scruffy determination" to his role, doing "an excellent job playing a character you can love or hate from week to week".
He was also praised for having a "very intense and intimate chemistry" with Rossum.
 
After an appearance in the third season of The Listener opposite Craig Olejnik, Chatwin played the lead in the TNT pilot Breed (2015), about a young detective who hunts down a rare breed of flesh eating criminals.
The pilot did not get picked up to series.
After that, he secured a recurring role in the third season of Orphan Black, opposite Tatiana Maslany and Kristian Bruun.
Next year, Chatwin landed the role of Cameron Hawthorne in the CBS summer series American Gothic, working with Antony Starr, Virginia Madsen and Megan Ketch.
The drama about a white-collar family who suspect that one of its members might be a serial killer, received mixed reviews from critics, who praised the performances, but calling it a "very standard and quite bland murder mystery", who is "destined to be forgotten".
American Gothic underperformed in the ratings, as a result, CBS cancelled the show after one season.
In the same year, he was seen in the BBC science fiction series Doctor Who in 2016 Christmas special "The Return of Doctor Mysterio", playing the superhero Grant Gordon / The Ghost.
The episode and his performance garnered favorable reviews, Vulture critic Ross Ruediger writing that "Chatwin is so at home in this universe, it might be fun to someday see the return of the Ghost", adding "the look Grant gives Lucy - that sort of 'Yeah... it's me' - is a quiet exclamation mark on a splendid performance from Chatwin".

In 2017, Chatwin signed on for an ABC pilot entitled The Doomsday Project, about a group of brilliant people who are asked to dream up man-made disaster scenarios and their possible solutions.
The pilot, directed by Joachim Rønning, was not picked up, but shortly after, it was announced that Sony Pictures Television was considering a series order for the project.
Couple of months later, VJ Boyd, the co-writer of the screenplay, confirmed the idea was dropped too.

Since 2019, Chatwin has starred as Erik Wallace in the ongoing television series Another Life.
In December 2009, Chatwin was filming the Showtime pilot Shameless, an adaptation of Paul Abbott's British series, starring opposite William H. Macy and Emmy Rossum (with whom he also starred in 2009's Dragonball Evolution). In April 2010, the network green-lit the show with a 12-episode order. During the course of three years, he was a series regular, playing Jimmy Lishman / Steve Wilton, Rossum's love interest. Chatwin returned in the fourth season finale, and appeared in the fifth season as a special guest star in the 6th and 7th episodes. The series received mostly positive reviews from critics. Chatwin was complimented for bringing "the right vibe of scruffy determination" to his role, doing "an excellent job playing a character you can love or hate from week to week". He was also praised for having a "very intense and intimate chemistry" with Rossum.  
After an appearance in the third season of The Listener opposite Craig Olejnik, Chatwin played the lead in the TNT pilot Breed (2015), about a young detective who hunts down a rare breed of flesh eating criminals. The pilot did not get picked up to series. After that, he secured a recurring role in the third season of Orphan Black, opposite Tatiana Maslany and Kristian Bruun. Next year, Chatwin landed the role of Cameron Hawthorne in the CBS summer series American Gothic, working with Antony Starr, Virginia Madsen and Megan Ketch. The drama about a white-collar family who suspect that one of its members might be a serial killer, received mixed reviews from critics, who praised the performances, but calling it a "very standard and quite bland murder mystery", who is "destined to be forgotten". American Gothic underperformed in the ratings, as a result, CBS cancelled the show after one season. In the same year, he was seen in the BBC science fiction series Doctor Who in 2016 Christmas special "The Return of Doctor Mysterio", playing the superhero Grant Gordon / The Ghost. The episode and his performance garnered favorable reviews, Vulture critic Ross Ruediger writing that "Chatwin is so at home in this universe, it might be fun to someday see the return of the Ghost", adding "the look Grant gives Lucy - that sort of 'Yeah... it's me' - is a quiet exclamation mark on a splendid performance from Chatwin". 
In 2017, Chatwin signed on for an ABC pilot entitled The Doomsday Project, about a group of brilliant people who are asked to dream up man-made disaster scenarios and their possible solutions. The pilot, directed by Joachim Rønning, was not picked up, but shortly after, it was announced that Sony Pictures Television was considering a series order for the project. Couple of months later, VJ Boyd, the co-writer of the screenplay, confirmed the idea was dropped too.
Since 2019, Chatwin has starred as Erik Wallace in the ongoing television series Another Life.
Justin Chatwin