Blaney was vice president of the Club Women's Franchise League.
In 1910 she supervised and financed a house-to-house canvass of the Santa Clara Valley on behalf of women's suffrage in a California special election on October 10, 1911.
She was on the executive board of the California Equal Suffrage Association.

In November 1911, in what was called a "striking feature" she was chosen a vice president of the La Follette League of California, an honor given for the "new voter" (California women).
Her name was greeted with "loud cheering" at the founding convention.
She was the "first woman in California to be given a post in a partisan political organization."

She switched to Theodore Roosevelt after Senator Robert M. La Follette quit the presidential race.

Blaney and Florence Collins Porter were reported to have been the first women to be delegates to any national political convention, but that distinction actually went to Therese A. Jenkins, a Republican delegate in 1892.
Asked how it felt to be the "first of their sex to cast votes in a national convention," she replied, "I just voted, that's all, and did not let myself be carried away by emotion at the time."
She and the other Californians were bound by state law to vote for the winner of the primary election, Theodore Roosevelt.
After Roosevelt lost the nomination to William Howard Taft, Blaney became a delegate to the Progressive Party convention that nominated Roosevelt on a separate ticket.
She and three other women were elected by women delegates to serve on the party's National Committee.

As a member of the Progressive Party, Blaney supported John M. Eshleman in his successful 1914 bid for California lieutenant governor.
Blaney was vice president of the Club Women's Franchise League. In 1910 she supervised and financed a house-to-house canvass of the Santa Clara Valley on behalf of women's suffrage in a California special election on October 10, 1911. She was on the executive board of the California Equal Suffrage Association.
In November 1911, in what was called a "striking feature" she was chosen a vice president of the La Follette League of California, an honor given for the "new voter" (California women). Her name was greeted with "loud cheering" at the founding convention. She was the "first woman in California to be given a post in a partisan political organization."
She switched to Theodore Roosevelt after Senator Robert M. La Follette quit the presidential race.
Blaney and Florence Collins Porter were reported to have been the first women to be delegates to any national political convention, but that distinction actually went to Therese A. Jenkins, a Republican delegate in 1892. Asked how it felt to be the "first of their sex to cast votes in a national convention," she replied, "I just voted, that's all, and did not let myself be carried away by emotion at the time." She and the other Californians were bound by state law to vote for the winner of the primary election, Theodore Roosevelt. After Roosevelt lost the nomination to William Howard Taft, Blaney became a delegate to the Progressive Party convention that nominated Roosevelt on a separate ticket. She and three other women were elected by women delegates to serve on the party's National Committee.
As a member of the Progressive Party, Blaney supported John M. Eshleman in his successful 1914 bid for California lieutenant governor.
Isabella W. Blaney