On 15 November 1863, Louise and Christian became Queen and King of Denmark.
The relationship between Louise and Christian seems to have been at least partially a marriage of love, and is described as happy: she supported him in his struggle to be acknowledged as heir to the throne of Denmark, and the couple became strongly attached to each other during the years of succession struggle.
Her loyalty is said to have been of great importance to him,  and Christian is described as dependent upon her intelligence, judgment and psychological strength, all of which were considered to be superior to his own.
Their life style is described as simple and puritan, and as this suited the contemporary view of an exemplary family life, the royal family was regarded as a morally correct role model.
Because of this, the pregnancy of her unmarried daughter Thyra in 1870 became a burden; Louise took control of the situation and hid it from public knowledge by sending Thyra to give birth abroad, keeping the whole affair a family secret.

As queen, Louise lived a life isolated from the people and did not seek a relationship with or recognition from the public.
She took no part in state affairs; her political interests focused on the arranged dynastic marriages of her children and were affected by her anti-German views.
The high status marriages she arranged for her children secured the newly established Danish dynasty international status, connecting Denmark to Great Britain, Russia, Sweden and Greece.
Known as "The Mother-in-law of Europe," her annual family gatherings at Bernstorff and Fredensborg attracted more attention every year and made her a popular symbol of family life.
Significant events in her life included her wedding anniversary on 26 May 1867, when she received great public praise; her birthday celebration of 1887; the wedding anniversary of 1892, and her 80th birthday in 1897.

The great dynastic success of Louise's six children was to a great extent a result of Louise's own ambitions rather than the efforts of her husband Christian IX.
Some have compared Louise's dynastic capabilities with those of Queen Victoria.

She was interested in music and painting.
She acted as the patron of artists such as Elisabeth Jerichau Baumann.
Some of Louise's own paintings were exhibited and given as gifts to members of other royal dynasties.

Louise supported 26 different charity organizations.
Among them were Vallø stift; Kronprinsesse Louises praktiske Tjenestepigeskole (The Servant Girls' School of Crown Princess Louise) and the Dronning Louises Børnehospital (Queen Louise's Children's Hospital).
In 1857, she founded the Louisestiftelsen (Louise Foundation), an orphanage for girls with the purpose of raising them to a life of domestic servants, which illustrated her deeply conservative ideals.
Her most known project, and one which she herself referred to as her most important, was the Diakonissestiftelsen (The Deaconess Foundation) in 1863, which introduced the Deaconess profession in Denmark.
In 1891, she initiated the Foreningen til Oprettelse af Friskolebørneasyler i Kbh.s Arbejderkvarter (Foundation for the Establishment of Charter school's Asylums in the Labour Quarters of Copenhagen).
She founded the Belønnings- og Forsørgelsesforeningen (The Reward- and Self-supporting Foundation) in 1881, supported domestic servants by providing financial aid to the ill, during unemployment and in retirement.
 Louise was deeply conservative, and her charitable work has been interpreted as a fear of socialism and the growing workers movement.
 
During her last years, she became deaf, and her needs were taken care of by two deaconesses from the Deaconess institution she founded.
Louise was queen for 35 years, longer than any other Danish queen before her.

On her death in 1898, she was interred in Roskilde Cathedral near Copenhagen.
On 15 November 1863, Louise and Christian became Queen and King of Denmark. The relationship between Louise and Christian seems to have been at least partially a marriage of love, and is described as happy: she supported him in his struggle to be acknowledged as heir to the throne of Denmark, and the couple became strongly attached to each other during the years of succession struggle. Her loyalty is said to have been of great importance to him,  and Christian is described as dependent upon her intelligence, judgment and psychological strength, all of which were considered to be superior to his own. Their life style is described as simple and puritan, and as this suited the contemporary view of an exemplary family life, the royal family was regarded as a morally correct role model. Because of this, the pregnancy of her unmarried daughter Thyra in 1870 became a burden; Louise took control of the situation and hid it from public knowledge by sending Thyra to give birth abroad, keeping the whole affair a family secret.
As queen, Louise lived a life isolated from the people and did not seek a relationship with or recognition from the public. She took no part in state affairs; her political interests focused on the arranged dynastic marriages of her children and were affected by her anti-German views. The high status marriages she arranged for her children secured the newly established Danish dynasty international status, connecting Denmark to Great Britain, Russia, Sweden and Greece. Known as "The Mother-in-law of Europe," her annual family gatherings at Bernstorff and Fredensborg attracted more attention every year and made her a popular symbol of family life. Significant events in her life included her wedding anniversary on 26 May 1867, when she received great public praise; her birthday celebration of 1887; the wedding anniversary of 1892, and her 80th birthday in 1897.
The great dynastic success of Louise's six children was to a great extent a result of Louise's own ambitions rather than the efforts of her husband Christian IX. Some have compared Louise's dynastic capabilities with those of Queen Victoria. 
She was interested in music and painting. She acted as the patron of artists such as Elisabeth Jerichau Baumann. Some of Louise's own paintings were exhibited and given as gifts to members of other royal dynasties.
Louise supported 26 different charity organizations. Among them were Vallø stift; Kronprinsesse Louises praktiske Tjenestepigeskole (The Servant Girls' School of Crown Princess Louise) and the Dronning Louises Børnehospital (Queen Louise's Children's Hospital). In 1857, she founded the Louisestiftelsen (Louise Foundation), an orphanage for girls with the purpose of raising them to a life of domestic servants, which illustrated her deeply conservative ideals. Her most known project, and one which she herself referred to as her most important, was the Diakonissestiftelsen (The Deaconess Foundation) in 1863, which introduced the Deaconess profession in Denmark. In 1891, she initiated the Foreningen til Oprettelse af Friskolebørneasyler i Kbh.s Arbejderkvarter (Foundation for the Establishment of Charter school's Asylums in the Labour Quarters of Copenhagen). She founded the Belønnings- og Forsørgelsesforeningen (The Reward- and Self-supporting Foundation) in 1881, supported domestic servants by providing financial aid to the ill, during unemployment and in retirement.  Louise was deeply conservative, and her charitable work has been interpreted as a fear of socialism and the growing workers movement.  
During her last years, she became deaf, and her needs were taken care of by two deaconesses from the Deaconess institution she founded. Louise was queen for 35 years, longer than any other Danish queen before her.
On her death in 1898, she was interred in Roskilde Cathedral near Copenhagen.
Louise of Hesse-Kassel