Butler was invited to the 2009 USA Basketball Men's World University Games Team training camp prior to his senior season.
Butler and the Top10-ranked Mountaineers opened up the season with a win over Loyola-Maryland, in which Butler recorded 26 points and 7 rebounds.
In a later win over Portland, Butler scored 26 points with 6 rebounds.
At the end of December, Butler hit a game-winning jumper to defeat Marquette, adding to his 17 total points.

After losing three games in early to mid-January, Butler and the Mountaineers bounced back with a win over #25 Ohio State and then a win over Louisville in which Butler scored 27 points.
In a following win over St. John's, Butler scored 33 points, then he added 32 points in a triple overtime loss to #23 Pittsburgh.
The Mountaineers ended their regular season with a 68–66 victory over #6 Villanova in which Butler had a double-double: 21 points and 10 rebounds.

In the Mountaineers' opening game of the Big East Tournament, West Virginia defeated Cincinnati with help from Butler, who banked in the game-winning three-pointer with no time left to win 54–51.
In the following 53–51 victory over Notre Dame in the semifinals, Butler scored 24 points.
In the championship game, Butler again led the Mountaineers to victory with the game-winning bucket over #22 Georgetown.
The victory was the first ever Big East title for the Mountaineers.

Entering the NCAA Tournament as a two-seed, the Mountaineers handled Morgan State in the opening round.
Butler scored 28 points and added 8 rebounds in the second round victory over Missouri.
After defeating Washington in the Sweet 16, the Mountaineers upset the 1-seed and tourney favorite Kentucky Wildcats 73–66, to advance to the school's second Final Four appearance.
Butler had 18 points in the Elite Eight victory, including finishing 4-8 from the 3-point line.

Butler and Duke's Jon Scheyer were the only finalists in 2010's Final Four for the Lowe's Senior CLASS Award for Men's Basketball, which on April 3, 2010, was awarded to Butler.
Later that day, in the second half of the Final Four loss to the Duke Blue Devils, Butler injured his left knee.
 Butler tore his ACL, sprained his MCL and sustained two bone bruises.

Butler was one of 10 finalists for the 2010 John R. Wooden Award.
It is given to the National Player of the Year in college basketball by The Los Angeles Athletic Club.
Butler was invited to the 2009 USA Basketball Men's World University Games Team training camp prior to his senior season. Butler and the Top10-ranked Mountaineers opened up the season with a win over Loyola-Maryland, in which Butler recorded 26 points and 7 rebounds. In a later win over Portland, Butler scored 26 points with 6 rebounds. At the end of December, Butler hit a game-winning jumper to defeat Marquette, adding to his 17 total points.
After losing three games in early to mid-January, Butler and the Mountaineers bounced back with a win over #25 Ohio State and then a win over Louisville in which Butler scored 27 points. In a following win over St. John's, Butler scored 33 points, then he added 32 points in a triple overtime loss to #23 Pittsburgh. The Mountaineers ended their regular season with a 68–66 victory over #6 Villanova in which Butler had a double-double: 21 points and 10 rebounds.
In the Mountaineers' opening game of the Big East Tournament, West Virginia defeated Cincinnati with help from Butler, who banked in the game-winning three-pointer with no time left to win 54–51. In the following 53–51 victory over Notre Dame in the semifinals, Butler scored 24 points. In the championship game, Butler again led the Mountaineers to victory with the game-winning bucket over #22 Georgetown. The victory was the first ever Big East title for the Mountaineers.
Entering the NCAA Tournament as a two-seed, the Mountaineers handled Morgan State in the opening round. Butler scored 28 points and added 8 rebounds in the second round victory over Missouri. After defeating Washington in the Sweet 16, the Mountaineers upset the 1-seed and tourney favorite Kentucky Wildcats 73–66, to advance to the school's second Final Four appearance. Butler had 18 points in the Elite Eight victory, including finishing 4-8 from the 3-point line.
Butler and Duke's Jon Scheyer were the only finalists in 2010's Final Four for the Lowe's Senior CLASS Award for Men's Basketball, which on April 3, 2010, was awarded to Butler. Later that day, in the second half of the Final Four loss to the Duke Blue Devils, Butler injured his left knee.  Butler tore his ACL, sprained his MCL and sustained two bone bruises.
Butler was one of 10 finalists for the 2010 John R. Wooden Award. It is given to the National Player of the Year in college basketball by The Los Angeles Athletic Club.
Da'Sean Butler