He married twice.

1 Cecilia Crofts (16??
 –1638) in 1636, a maid of honour to Queen Henrietta Maria with a son:
Henry Killigrew (bapt 16 April 1637 St Martin's-in-the-Fields)
2 Charlotte de Hesse (1629 –1716) in 1655; with children:
Charles Killigrew (29 December 1655–1725)
Thomas Killigrew (the younger) (1657 –1719), who had one successful play, called Chit-Chat (1719)
Robert (Roger) Killigrew (born 17 September 1663)
Elizabeth Killigrew (born 3 July 1666)
His second wife and their 3 sons were naturalised in an Act of Parliament in 1683.
He married twice.
1 Cecilia Crofts (16?? –1638) in 1636, a maid of honour to Queen Henrietta Maria with a son:
Henry Killigrew (bapt 16 April 1637 St Martin's-in-the-Fields)
2 Charlotte de Hesse (1629 –1716) in 1655; with children:
Charles Killigrew (29 December 1655–1725)
Thomas Killigrew (the younger) (1657 –1719), who had one successful play, called Chit-Chat (1719)
Robert (Roger) Killigrew (born 17 September 1663)
Elizabeth Killigrew (born 3 July 1666)
His second wife and their 3 sons were naturalised in an Act of Parliament in 1683.
Thomas Killigrew