Mihrimah's life was uncertain after Selim's death in 1574.
Some say she lost all her power and retired at the Old Palace.
However it is most likely that Mihrimah kept her position at Topkapı Palace and continued to share her power with Nurbanu, the new Valide Sultan, until her own death, and was the only Imperial Princess to be ranked with Nurbanu Sultan (Murad's mother) and above Safiye Sultan (Murad's wife) in the royal court.

Mihrimah died in Istanbul on 25 January 1578 during the reign of her nephew Murad III, outliving all of her siblings.
She is the only one of Suleiman's children to be buried in his tomb, the Süleymaniye Mosque complex.
Mihrimah's life was uncertain after Selim's death in 1574. Some say she lost all her power and retired at the Old Palace. However it is most likely that Mihrimah kept her position at Topkapı Palace and continued to share her power with Nurbanu, the new Valide Sultan, until her own death, and was the only Imperial Princess to be ranked with Nurbanu Sultan (Murad's mother) and above Safiye Sultan (Murad's wife) in the royal court.
Mihrimah died in Istanbul on 25 January 1578 during the reign of her nephew Murad III, outliving all of her siblings. She is the only one of Suleiman's children to be buried in his tomb, the Süleymaniye Mosque complex.
Mihrimah Sultan (daughter of Suleiman I)