No major highways enter the city limits of Annapolis.
However, just outside the city limits, Interstate 595/U.S. Route 50/U.S. Route 301 traverses the region on an east–west route, connecting the Annapolis area to Washington, D.C., and the Eastern Shore of Maryland.
Interstate 97 interchanges with I-595/US 50/US 301 a few miles west of Annapolis and provides the most direct link to Baltimore.
Maryland Route 2 also passes just outside the city limits and is the best connection to Southern Maryland, while also providing an alternate route to Baltimore.

The most prominent roads directly accessing the city include Maryland Route 70, which connects downtown Annapolis to I-595/US 50/US 301, and Maryland Route 665, which does likewise for the southwestern portions of the city.
Other state highways serving Annapolis include Maryland Route 181, Maryland Route 387, Maryland Route 393, Maryland Route 435, Maryland Route 436, Maryland Route 450, Maryland Route 788 and Maryland Route 797.
No major highways enter the city limits of Annapolis. However, just outside the city limits, Interstate 595/U.S. Route 50/U.S. Route 301 traverses the region on an east–west route, connecting the Annapolis area to Washington, D.C., and the Eastern Shore of Maryland. Interstate 97 interchanges with I-595/US 50/US 301 a few miles west of Annapolis and provides the most direct link to Baltimore. Maryland Route 2 also passes just outside the city limits and is the best connection to Southern Maryland, while also providing an alternate route to Baltimore.
The most prominent roads directly accessing the city include Maryland Route 70, which connects downtown Annapolis to I-595/US 50/US 301, and Maryland Route 665, which does likewise for the southwestern portions of the city. Other state highways serving Annapolis include Maryland Route 181, Maryland Route 387, Maryland Route 393, Maryland Route 435, Maryland Route 436, Maryland Route 450, Maryland Route 788 and Maryland Route 797.
Annapolis, Maryland