The Bx12 runs crosstown from Inwood in Manhattan to various areas in the northeastern Bronx.
The line, eastward, begins at the Inwood–207th Street subway station (A train) on Broadway and West 207th Street.
The Bx12 then loops around via Isham Street and Sherman Avenue and rejoins West 207th Street, continuing across the University Heights Bridge into University Heights.
The route runs along Fordham Road through Fordham Center, Fordham Plaza, and Belmont until the road becomes Pelham Parkway near the Bronx Zoo and New York Botanical Garden in Bronx Park.
The route then runs along Pelham Parkway's main roadway to Pelham Bay, where it takes a somewhat circuitous route.
The line turns off Pelham Parkway onto Burr Avenue stopping at the Pelham Bay Park subway station.
From here, the Bx12 services that do not terminate here make a U-turn and join the New England Thruway to Bay Plaza or veer east along Shore Road to Orchard Beach.

At the Pelham Bay Park station, Manhattan-bound buses use stops directly adjacent to where Bay Plaza and Orchard Beach-bound buses pick up passengers—along southbound Amendola Place.
Westbound buses use the southernmost two stops, while terminating eastbound locals and buses towards Bay Plaza and Orchard Beach use the northernmost two stops closest to the subway.
The setup requires westbound service to make a U-turn onto the New England Thruway before heading onto Pelham Parkway.

During the daytime and evening hours, local service runs between Sedgwick/Webb Avenue in University Heights and the Pelham Bay Park subway station (6 and <6>​ trains).
Some local service also originates from Belmont Avenue and 182nd Street in Belmont during the afternoons on school days.
Most service between Manhattan and Bay Plaza is served by Bx12 Select buses during that time, although some local buses continue to Bay Plaza.
During the summer, Bx12 local buses are extended to Orchard Beach, with all weekend service operating to/from Inwood during the summer.

During the overnight hours, all service runs local, serving the entire route with the exception of Bay Plaza.
Buses instead terminate on Edson Avenue, in front of the Gun Hill Bus Depot, as the shopping center is closed during these times.
The Bx12 runs crosstown from Inwood in Manhattan to various areas in the northeastern Bronx. The line, eastward, begins at the Inwood–207th Street subway station (A train) on Broadway and West 207th Street. The Bx12 then loops around via Isham Street and Sherman Avenue and rejoins West 207th Street, continuing across the University Heights Bridge into University Heights. The route runs along Fordham Road through Fordham Center, Fordham Plaza, and Belmont until the road becomes Pelham Parkway near the Bronx Zoo and New York Botanical Garden in Bronx Park. The route then runs along Pelham Parkway's main roadway to Pelham Bay, where it takes a somewhat circuitous route. The line turns off Pelham Parkway onto Burr Avenue stopping at the Pelham Bay Park subway station. From here, the Bx12 services that do not terminate here make a U-turn and join the New England Thruway to Bay Plaza or veer east along Shore Road to Orchard Beach.
At the Pelham Bay Park station, Manhattan-bound buses use stops directly adjacent to where Bay Plaza and Orchard Beach-bound buses pick up passengers—along southbound Amendola Place. Westbound buses use the southernmost two stops, while terminating eastbound locals and buses towards Bay Plaza and Orchard Beach use the northernmost two stops closest to the subway. The setup requires westbound service to make a U-turn onto the New England Thruway before heading onto Pelham Parkway.
During the daytime and evening hours, local service runs between Sedgwick/Webb Avenue in University Heights and the Pelham Bay Park subway station (6 and <6>​ trains). Some local service also originates from Belmont Avenue and 182nd Street in Belmont during the afternoons on school days. Most service between Manhattan and Bay Plaza is served by Bx12 Select buses during that time, although some local buses continue to Bay Plaza. During the summer, Bx12 local buses are extended to Orchard Beach, with all weekend service operating to/from Inwood during the summer.
During the overnight hours, all service runs local, serving the entire route with the exception of Bay Plaza. Buses instead terminate on Edson Avenue, in front of the Gun Hill Bus Depot, as the shopping center is closed during these times.
Bx12 bus