Hoffman next appeared in Moonlight Mile (2002), followed by Confidence (2003) opposite Edward Burns, Andy García and Rachel Weisz.
Hoffman finally had a chance to work with Gene Hackman in Gary Fleder's Runaway Jury (also 2003), an adaptation of John Grisham's bestselling novel.

Hoffman played theater owner Charles Frohman in the J. M. Barrie historical fantasia Finding Neverland (2004), costarring Johnny Depp and Kate Winslet.
In director David O. Russell's I Heart Huckabees (also 2004), Hoffman appeared opposite Lily Tomlin as an existential detective team member.

Seven years after his nomination for Wag the Dog, Hoffman got another opportunity to perform again with Robert De Niro, co-starring with Barbra Streisand and Ben Stiller in the 2004 comedy Meet the Fockers, a sequel to Meet the Parents (2000).
Hoffman won the 2005 MTV Movie Award for Best Comedic Performance.
In 2005, he voiced a horse in Racing Stripes, and appeared in cameo roles in Andy García's The Lost City and on the final episode of HBO sitcom Curb Your Enthusiasm's fifth season.
Hoffman appeared in Stranger than Fiction (2006), played the perfumer Giuseppe Baldini in Tom Tykwer's film Perfume: The Story of a Murderer (also 2006), and had a cameo in the same year's The Holiday.

In 2007, he was featured in an advertising campaign for Australian telecommunications company Telstra's Next G network, appeared in the 50 Cent video "Follow My Lead" as a psychiatrist, and played the title character in the family film Mr. Magorium's Wonder Emporium.
In 2008, although he was reluctant to perform in an animated feature film (Although he had previously performed voices in a version of The Point!
and in an episode of The Simpsons), Hoffman had a prominent role as Shifu in the film Kung Fu Panda, which was praised in part for his comedic chemistry with Jack Black (whom he tutored in acting for an important scene) and his character's poignantly complex relationship with the story's villain.
He later won the Annie Award for Voice Acting in an Animated Feature for Kung Fu Panda and has continued into the role in the franchise's subsequent filmed productions outside of the franchise's television series.
He next voiced Roscuro in The Tale of Despereaux.

As the title character in Last Chance Harvey, Hoffman acted with co-star Emma Thompson in the story of two lonely people who tentatively forge a relationship over the course of three days.
Director Joel Hopkins notes that Hoffman was a perfectionist and self-critical: "He often wanted to try things stripped down, because less is sometimes more.
He worries about every little detail."
Hoffman next appeared in Moonlight Mile (2002), followed by Confidence (2003) opposite Edward Burns, Andy García and Rachel Weisz. Hoffman finally had a chance to work with Gene Hackman in Gary Fleder's Runaway Jury (also 2003), an adaptation of John Grisham's bestselling novel.
Hoffman played theater owner Charles Frohman in the J. M. Barrie historical fantasia Finding Neverland (2004), costarring Johnny Depp and Kate Winslet. In director David O. Russell's I Heart Huckabees (also 2004), Hoffman appeared opposite Lily Tomlin as an existential detective team member.
Seven years after his nomination for Wag the Dog, Hoffman got another opportunity to perform again with Robert De Niro, co-starring with Barbra Streisand and Ben Stiller in the 2004 comedy Meet the Fockers, a sequel to Meet the Parents (2000). Hoffman won the 2005 MTV Movie Award for Best Comedic Performance. In 2005, he voiced a horse in Racing Stripes, and appeared in cameo roles in Andy García's The Lost City and on the final episode of HBO sitcom Curb Your Enthusiasm's fifth season. Hoffman appeared in Stranger than Fiction (2006), played the perfumer Giuseppe Baldini in Tom Tykwer's film Perfume: The Story of a Murderer (also 2006), and had a cameo in the same year's The Holiday.
In 2007, he was featured in an advertising campaign for Australian telecommunications company Telstra's Next G network, appeared in the 50 Cent video "Follow My Lead" as a psychiatrist, and played the title character in the family film Mr. Magorium's Wonder Emporium. In 2008, although he was reluctant to perform in an animated feature film (Although he had previously performed voices in a version of The Point! and in an episode of The Simpsons), Hoffman had a prominent role as Shifu in the film Kung Fu Panda, which was praised in part for his comedic chemistry with Jack Black (whom he tutored in acting for an important scene) and his character's poignantly complex relationship with the story's villain. He later won the Annie Award for Voice Acting in an Animated Feature for Kung Fu Panda and has continued into the role in the franchise's subsequent filmed productions outside of the franchise's television series. He next voiced Roscuro in The Tale of Despereaux.
As the title character in Last Chance Harvey, Hoffman acted with co-star Emma Thompson in the story of two lonely people who tentatively forge a relationship over the course of three days. Director Joel Hopkins notes that Hoffman was a perfectionist and self-critical: "He often wanted to try things stripped down, because less is sometimes more. He worries about every little detail."
Dustin Hoffman