The base was opened on 21 October 1942 and during the Second World War performed Boeing B-17 Flying Fortress aircrew training.
It was placed on inactive status on 23 September 1946, although a small cadre of Army and Air Force personnel (331 Composite Squadron) remained assigned to Alexandria Municipal Airport throughout the late 1940s.

On 10 October 1950, the United States Air Force reopened Alexandria Air Force Base during the Korean War.
The station's primary mission was tactical fighter operations for Tactical Air Command.

Its major operating units were:
United States Army Air Forces
67th Airdrome Squadron, 1 February 1943 – 25 March 1943
471st Bombardment Group, 1 May 1943 – 7 May 1943
469th Bombardment Group, 7 May 1943 – 1 April 1944
221st AAF Base Unit, 25 March 1944 – 1 March 1945
329th AAF Base Unit, 1 March 1945 – 23 September 1946
United States Air Force
4416th Base Complement Sq, 23 October 1950 – 22 December 1950
137th Fighter-Bomber Wing, 22 December 1950 – 2 May 1952
Composite Air National Guard wing activated to Federal Service due to Korean War
Flew Republic F-84 "Thunderjets".
Three operational squadrons 125th (Oklahoma ANG, F-84B/G, 127th (Kansas ANG F-84C/G), 128th (Georgia ANG, F-84B/G)).
ANG personnel trained at Alexandria AFB 1950/51, being replaced by active duty Air Force personnel in 1951/52.
Wing reassigned to USAFE at Chaumont-Semoutiers Air Base, France
132d Fighter-Bomber Wing, 2 May 1952 – 1 January 1953
Iowa ANG Wing activated to Federal Service replacing reassigned 137th FBW
One operational squadron (124th FIS).
Flew Republic straight winged F-84s.
Returned to state control.(F-84Fs were not assigned to front line units until January 1954-please see pages 42/3 in POST WORLD WAR TWO FIGHTERS 1945-73 U S Government Printing Office)
366th Fighter-Bomber Wing, 1 January 1953 – 1 April 1959
Active duty Air Force wing activated at Alexandria AFB.
Three operational squadrons (389th, 390th, 391st) being initially equipped with North American F-51D Mustang, reequipped with North American F-86F "Sabre" jet aircraft by end of 1953.

Wing became first TAC unit to perform six-month TDY rotations with NATO at Aviano AB, Italy, with rotations continuing to support NATO in France and Italy.
Redesignated 366th Tactical Fighter Wing 1 July 1958.
Inactivated 1 April 1959 as part of a general budgetary reduction of USAF wings.
Aircraft transferred to Air National Guard.

420th Air Refueling Squadron (Tactical), 18 March 1954 – 4 October 1955
(Activated at England AFB, equipped with Boeing KB-29P.
First unit in TAC of its type.
Provided TAC with independent air refueling capability.
Reassigned to USAFE at RAF Sculthorpe, England.

622d Air Refueling Squadron (Tactical), 18 July 1955 – 1 April 1964
Activated at England AFB, assigned to 4505th Air Refueling Wing, Langley AFB, Virginia 1 July 1958.

Equipped with Boeing KB-29P (1955–57), later turbojet-augmented Boeing KB-50J (1957–64) aircraft.
Aircraft became obsolescent and unit inactivated 1 April 1964.

401st Tactical Fighter Wing, 1 April 1959 – 27 April 1966
According to AIR FORCE COMBAT WINGS 1947-1977(GPO) pages 194/5 and 214, the 366th FBW had two FB Groups under it: 366th & 401st.
The 366th WING became a TFW in July 1958 and inactivated in April 1959.
Meanwhile, the 401st FBG upgraded to a FBW in September 1957 and remained in place with four squadrons of F-100D/Fs.
The aircraft and most of the personnel of the 366th Wing were transferred to other units in TAC and overseas.
There was no redesignations of any 366th squadrons to 401st squadrons.

Four tactical fighter squadrons (612th, 613th, 614th, 615th) redesignated from former 366th TFW units.
Participated in numerous firepower demonstrations, tactical exercises and maneuvers in the United States and overseas, and deployed its tactical squadrons to bases in Europe and the Middle East in support of NATO.
Deployed to Homestead AFB, Florida during Cuban Missile Crisis (1962) as tactical airstrike unit.
Wing designation along with 613th TFS reassigned to USAFE at Torrejon Air Base, Spain.

3d Tactical Fighter
The base was opened on 21 October 1942 and during the Second World War performed Boeing B-17 Flying Fortress aircrew training. It was placed on inactive status on 23 September 1946, although a small cadre of Army and Air Force personnel (331 Composite Squadron) remained assigned to Alexandria Municipal Airport throughout the late 1940s.
On 10 October 1950, the United States Air Force reopened Alexandria Air Force Base during the Korean War. The station's primary mission was tactical fighter operations for Tactical Air Command.
Its major operating units were:
United States Army Air Forces
67th Airdrome Squadron, 1 February 1943 – 25 March 1943
471st Bombardment Group, 1 May 1943 – 7 May 1943
469th Bombardment Group, 7 May 1943 – 1 April 1944
221st AAF Base Unit, 25 March 1944 – 1 March 1945
329th AAF Base Unit, 1 March 1945 – 23 September 1946
United States Air Force
4416th Base Complement Sq, 23 October 1950 – 22 December 1950
137th Fighter-Bomber Wing, 22 December 1950 – 2 May 1952
Composite Air National Guard wing activated to Federal Service due to Korean War
Flew Republic F-84 "Thunderjets". Three operational squadrons 125th (Oklahoma ANG, F-84B/G, 127th (Kansas ANG F-84C/G), 128th (Georgia ANG, F-84B/G)). ANG personnel trained at Alexandria AFB 1950/51, being replaced by active duty Air Force personnel in 1951/52. Wing reassigned to USAFE at Chaumont-Semoutiers Air Base, France
132d Fighter-Bomber Wing, 2 May 1952 – 1 January 1953
Iowa ANG Wing activated to Federal Service replacing reassigned 137th FBW
One operational squadron (124th FIS). Flew Republic straight winged F-84s. Returned to state control.(F-84Fs were not assigned to front line units until January 1954-please see pages 42/3 in POST WORLD WAR TWO FIGHTERS 1945-73 U S Government Printing Office)
366th Fighter-Bomber Wing, 1 January 1953 – 1 April 1959
Active duty Air Force wing activated at Alexandria AFB. Three operational squadrons (389th, 390th, 391st) being initially equipped with North American F-51D Mustang, reequipped with North American F-86F "Sabre" jet aircraft by end of 1953.
Wing became first TAC unit to perform six-month TDY rotations with NATO at Aviano AB, Italy, with rotations continuing to support NATO in France and Italy. Redesignated 366th Tactical Fighter Wing 1 July 1958. Inactivated 1 April 1959 as part of a general budgetary reduction of USAF wings. Aircraft transferred to Air National Guard.
420th Air Refueling Squadron (Tactical), 18 March 1954 – 4 October 1955
(Activated at England AFB, equipped with Boeing KB-29P.
First unit in TAC of its type. Provided TAC with independent air refueling capability. Reassigned to USAFE at RAF Sculthorpe, England.
622d Air Refueling Squadron (Tactical), 18 July 1955 – 1 April 1964
Activated at England AFB, assigned to 4505th Air Refueling Wing, Langley AFB, Virginia 1 July 1958.
Equipped with Boeing KB-29P (1955–57), later turbojet-augmented Boeing KB-50J (1957–64) aircraft. Aircraft became obsolescent and unit inactivated 1 April 1964.
401st Tactical Fighter Wing, 1 April 1959 – 27 April 1966
According to AIR FORCE COMBAT WINGS 1947-1977(GPO) pages 194/5 and 214, the 366th FBW had two FB Groups under it: 366th & 401st. The 366th WING became a TFW in July 1958 and inactivated in April 1959. Meanwhile, the 401st FBG upgraded to a FBW in September 1957 and remained in place with four squadrons of F-100D/Fs. The aircraft and most of the personnel of the 366th Wing were transferred to other units in TAC and overseas. There was no redesignations of any 366th squadrons to 401st squadrons.
Four tactical fighter squadrons (612th, 613th, 614th, 615th) redesignated from former 366th TFW units. Participated in numerous firepower demonstrations, tactical exercises and maneuvers in the United States and overseas, and deployed its tactical squadrons to bases in Europe and the Middle East in support of NATO. Deployed to Homestead AFB, Florida during Cuban Missile Crisis (1962) as tactical airstrike unit. Wing designation along with 613th TFS reassigned to USAFE at Torrejon Air Base, Spain.
3d Tactical Fighter 
England Air Force Base