In 2003, Madrigal successfully auditioned for a starring role on The Ortegas, a comedy series for the Fox Network.
The series, which was based on the BBC comedy The Kumars at No.
42, cast Madrigal as the son of a Mexican American family in California who hosts a TV talk show from a studio he operates in the backyard of his parents' home.
However, the network dropped the series from its schedule before broadcasting any of its six filmed episodes.

In January 2008, Madrigal was cast as a building attendant named Jesús (pronounced “Hey-Soose”) in the CBS comedy Welcome to The Captain.
The series was cancelled after five episodes.

He co-starred in the CBS series Gary Unmarried (originally titled Project Gary), which debuted in September 2008.

On March 14, 2013, it was announced that Madrigal would be joining NBC's About A Boy as Andy, the main character's best friend.
He received a 2014 Imagen Awards nomination for Best Supporting Actor for his work in the role.

Madrigal was a series regular on the Showtime series I'm Dying Up Here.
He played a stand-up comedian named Edgar in the dark comedy about Los Angeles' infamous stand-up comedy scene of the 1970s.
The show, which is based on William Knoedelseder's nonfiction book of the same name, is executive produced by Jim Carrey.
In 2003, Madrigal successfully auditioned for a starring role on The Ortegas, a comedy series for the Fox Network. The series, which was based on the BBC comedy The Kumars at No. 42, cast Madrigal as the son of a Mexican American family in California who hosts a TV talk show from a studio he operates in the backyard of his parents' home. However, the network dropped the series from its schedule before broadcasting any of its six filmed episodes.
In January 2008, Madrigal was cast as a building attendant named Jesús (pronounced “Hey-Soose”) in the CBS comedy Welcome to The Captain. The series was cancelled after five episodes.
He co-starred in the CBS series Gary Unmarried (originally titled Project Gary), which debuted in September 2008.
On March 14, 2013, it was announced that Madrigal would be joining NBC's About A Boy as Andy, the main character's best friend. He received a 2014 Imagen Awards nomination for Best Supporting Actor for his work in the role.
Madrigal was a series regular on the Showtime series I'm Dying Up Here. He played a stand-up comedian named Edgar in the dark comedy about Los Angeles' infamous stand-up comedy scene of the 1970s. The show, which is based on William Knoedelseder's nonfiction book of the same name, is executive produced by Jim Carrey.
Al Madrigal