These two ribonucleases are most likely evolutionarily related through a common ancestor, since they have common protein subunits and can be folded into very similar secondary structures.
There are many conserved regions in these two ribonucleases.
Sequences of the CR-I, CR-V, and CR-IV genes in domain 1 of the P4 helical region are conserved, with the consensus sequence in CR-IV being AGNNNNA for RNAse P and AGNNA for RNase MRP.
CR-II and CR-III are also conserved in domain 2 of P RNA.
The P3 helix is also conserved in both ribonucleases in all eukaryotes, but the function of this helix is not yet clear.
These conserved regions are evidence of the close phylogenetic relation between these two important ribonucleoprotein complexes.
These two ribonucleases are most likely evolutionarily related through a common ancestor, since they have common protein subunits and can be folded into very similar secondary structures. There are many conserved regions in these two ribonucleases. Sequences of the CR-I, CR-V, and CR-IV genes in domain 1 of the P4 helical region are conserved, with the consensus sequence in CR-IV being AGNNNNA for RNAse P and AGNNA for RNase MRP. CR-II and CR-III are also conserved in domain 2 of P RNA. The P3 helix is also conserved in both ribonucleases in all eukaryotes, but the function of this helix is not yet clear. These conserved regions are evidence of the close phylogenetic relation between these two important ribonucleoprotein complexes.
RNase MRP