As of 2016 all employment growth in the area since 2000 has been in Neighboring Kansas, mostly in Johnson County.
The federal government is the largest employer in the Kansas City metro area.
More than 146 federal agencies maintain a presence there.
Kansas City is one of ten regional office cities for the US government.
The Internal Revenue Service maintains a large service center in Kansas City that occupies nearly 1.4 million square feet (130,000 m²).
It is one of only two sites to process paper returns.
The IRS has approximately 2,700 full-time employees in Kansas City, growing to 4,000 during tax season.
The General Services Administration has more than 800 employees.
Most are at the Bannister Federal Complex in South Kansas City.
The Bannister Complex was also home to the Kansas City Plant, which is a National Nuclear Security Administration facility operated by Honeywell.
The Kansas City Plant has since been moved to a new location on Botts Road.
Honeywell employs nearly 2,700 at the Kansas City Plant, which produces and assembles 85% of the non-nuclear components of the United States nuclear bomb arsenal.
The Social Security Administration has more than 1,700 employees in the Kansas City area, with more than 1,200 at its downtown Mid-America Program Service Center (MAMPSC).
The United States Postal Service operates post offices in Kansas City.
The Kansas City Main Post Office is at 300 West Pershing Road.

In 2019, the US Department of Agriculture relocated two federal research labs, ERS and NIFA, to the metro area.
This move was consider controversial at the time of announcement, and resulted in multiple people leaving the agencies.
The new location for these agencies will be in the downtown area.

Ford Motor Company operates a large manufacturing facility in Claycomo at the Ford Kansas City Assembly Plant, which builds the Ford F-150.
The General Motors Fairfax Assembly Plant is in adjacent Kansas City, Kansas.
Now shuttered Smith Electric Vehicles built electric vehicles in the former TWA/American Airlines overhaul facility at Kansas City International Airport until 2017.

One of the largest US drug manufacturing plants is the Sanofi-Aventis plant in south Kansas City on a campus developed by Ewing Kauffman's Marion Laboratories.
Of late, it has been developing academic and economic institutions related to animal health sciences, an effort most recently bolstered by the selection of Manhattan, Kansas, at one end of the Kansas City Animal Health Corridor, as the site for the National Bio and Agro-Defense Facility, which researches animal diseases.
Additionally, the Stowers Institute for Medical Research engages in medical basic science research.
They offer educational opportunities for both predoctoral and postdoctoral candidates and work with Open University and University of Kansas Medical Center in a joint Interdisciplinary Graduate Program in Biomedical Science (IGPBS).

Numerous agriculture companies operate out of the city.
Dairy Farmers of America, the largest dairy co-op in the United States is located in northern Kansas City.
The National Association of Intercollegiate Athletics and The National Association of Basketball Coaches are based in Kansas City.

The business community is serviced by two major business magazines, the Kansas City Business Journal (published weekly) and Ingram's Magazine (published monthly), as well as other publications, including a local society journal, the Independent (published weekly).

The Kansas City Federal Reserve Bank built a new building that opened in 2008 near Union Station.
Missouri is the only state to have two of the 12 Federal Reserve Bank headquarters (the second is in St. Louis).
Kansas City's effort to get the bank was helped by former mayor James A. Reed, who as senator, broke a tie to pass the Federal Reserve Act.

The national headquarters for the Veterans of Foreign Wars is headquartered just south of Downtown.

With a Gross Metropolitan Product of $41.68 billion in 2004, Kansas City's (Missouri side only) economy makes up 20.5% of Missouri's gross state product.
As of 2016 all employment growth in the area since 2000 has been in Neighboring Kansas, mostly in Johnson County. The federal government is the largest employer in the Kansas City metro area. More than 146 federal agencies maintain a presence there. Kansas City is one of ten regional office cities for the US government. The Internal Revenue Service maintains a large service center in Kansas City that occupies nearly 1.4 million square feet (130,000 m²). It is one of only two sites to process paper returns. The IRS has approximately 2,700 full-time employees in Kansas City, growing to 4,000 during tax season. The General Services Administration has more than 800 employees. Most are at the Bannister Federal Complex in South Kansas City. The Bannister Complex was also home to the Kansas City Plant, which is a National Nuclear Security Administration facility operated by Honeywell. The Kansas City Plant has since been moved to a new location on Botts Road. Honeywell employs nearly 2,700 at the Kansas City Plant, which produces and assembles 85% of the non-nuclear components of the United States nuclear bomb arsenal. The Social Security Administration has more than 1,700 employees in the Kansas City area, with more than 1,200 at its downtown Mid-America Program Service Center (MAMPSC). The United States Postal Service operates post offices in Kansas City. The Kansas City Main Post Office is at 300 West Pershing Road.
In 2019, the US Department of Agriculture relocated two federal research labs, ERS and NIFA, to the metro area. This move was consider controversial at the time of announcement, and resulted in multiple people leaving the agencies. The new location for these agencies will be in the downtown area.
Ford Motor Company operates a large manufacturing facility in Claycomo at the Ford Kansas City Assembly Plant, which builds the Ford F-150. The General Motors Fairfax Assembly Plant is in adjacent Kansas City, Kansas. Now shuttered Smith Electric Vehicles built electric vehicles in the former TWA/American Airlines overhaul facility at Kansas City International Airport until 2017.
One of the largest US drug manufacturing plants is the Sanofi-Aventis plant in south Kansas City on a campus developed by Ewing Kauffman's Marion Laboratories. Of late, it has been developing academic and economic institutions related to animal health sciences, an effort most recently bolstered by the selection of Manhattan, Kansas, at one end of the Kansas City Animal Health Corridor, as the site for the National Bio and Agro-Defense Facility, which researches animal diseases. Additionally, the Stowers Institute for Medical Research engages in medical basic science research. They offer educational opportunities for both predoctoral and postdoctoral candidates and work with Open University and University of Kansas Medical Center in a joint Interdisciplinary Graduate Program in Biomedical Science (IGPBS).
Numerous agriculture companies operate out of the city. Dairy Farmers of America, the largest dairy co-op in the United States is located in northern Kansas City. The National Association of Intercollegiate Athletics and The National Association of Basketball Coaches are based in Kansas City.
The business community is serviced by two major business magazines, the Kansas City Business Journal (published weekly) and Ingram's Magazine (published monthly), as well as other publications, including a local society journal, the Independent (published weekly).
The Kansas City Federal Reserve Bank built a new building that opened in 2008 near Union Station. Missouri is the only state to have two of the 12 Federal Reserve Bank headquarters (the second is in St. Louis). Kansas City's effort to get the bank was helped by former mayor James A. Reed, who as senator, broke a tie to pass the Federal Reserve Act.
The national headquarters for the Veterans of Foreign Wars is headquartered just south of Downtown.
With a Gross Metropolitan Product of $41.68 billion in 2004, Kansas City's (Missouri side only) economy makes up 20.5% of Missouri's gross state product.
Kansas City, Missouri