where are stem cells found in human body
Stem cell
However , reprogramming allows for the creation of pluripotent cells , induced pluripotent stem cells , from adult cells . It is important to note that these are not adult stem cells , but adult cells ( e.g. epithelial cells ) reprogrammed to give rise to cells with pluripotent capabilities . Using genetic reprogramming with protein transcription factors , pluripotent stem cells with ESC - like capabilities have been derived . The first demonstration of Induced Pluripotent Stem Cells was conducted by Shinya Yamanaka and his colleagues at Kyoto University . They used the transcription factors Oct3 / 4 , Sox2 , c - Myc , and Klf4 to reprogram mouse fibroblast cells into pluripotent cells . Subsequent work used these factors to induce pluripotency in human fibroblast cells . Junying Yu , James Thomson , and their colleagues at the University of Wisconsin -- Madison used a different set of factors , Oct4 , Sox2 , Nanog and Lin28 , and carried out their experiments using cells from human foreskin . However , they were able to replicate Yamanaka 's finding that inducing pluripotency in human cells was possible .
However , reprogramming allows for the creation of pluripotent cells , induced pluripotent stem cells , from adult cells . It is important to note that these are not adult stem cells , but adult cells ( e.g. epithelial cells ) reprogrammed to give rise to cells with pluripotent capabilities . Using genetic reprogramming with protein transcription factors , pluripotent stem cells with ESC - like capabilities have been derived . The first demonstration of Induced Pluripotent Stem Cells was conducted by Shinya Yamanaka and his colleagues at Kyoto University . They used the transcription factors Oct3 / 4 , Sox2 , c - Myc , and Klf4 to reprogram mouse fibroblast cells into pluripotent cells . Subsequent work used these factors to induce pluripotency in human fibroblast cells . Junying Yu , James Thomson , and their colleagues at the University of Wisconsin -- Madison used a different set of factors , Oct4 , Sox2 , Nanog and Lin28 , and carried out their experiments using cells from human foreskin . However , they were able to replicate Yamanaka 's finding that inducing pluripotency in human cells was possible .