when were statins first prescribed in the uk
Statin
Statin equivalent dosages % LDL reduction ( approx . ) Atorvastatin Fluvastatin Lovastatin Pravastatin Rosuvastatin Simvastatin 10 -- 20 % -- 20 mg 10 mg 10 mg -- 5 mg 20 -- 30 % -- 40 mg 20 mg 20 mg -- 10 mg 30 -- 40 % 10 mg 80 mg 40 mg 40 mg 5 mg 20 mg 40 -- 45 % 20 mg -- 80 mg 80 mg 5 -- 10 mg 40 mg 46 -- 50 % 40 mg -- -- -- 10 -- 20 mg 80 mg * 50 -- 55 % 80 mg -- -- -- 20 mg -- 56 -- 60 % -- -- -- -- 40 mg -- * 80 - mg dose no longer recommended due to increased risk of rhabdomyolysis Starting dose Starting dose 10 -- 20 mg 20 mg 10 -- 20 mg 40 mg 10 mg ; 5 mg if hypothyroid , > 65 yo , Asian 20 mg If higher LDL reduction goal 40 mg if > 45 % 40 mg if > 25 % 20 mg if > 20 % -- 20 mg if LDL > 190 mg / dL ( 4.87 mmol / L ) 40 mg if > 45 % Optimal timing Anytime Evening With evening meals Anytime Anytime Evening
Statin equivalent dosages % LDL reduction ( approx . ) Atorvastatin Fluvastatin Lovastatin Pravastatin Rosuvastatin Simvastatin 10 -- 20 % -- 20 mg 10 mg 10 mg -- 5 mg 20 -- 30 % -- 40 mg 20 mg 20 mg -- 10 mg 30 -- 40 % 10 mg 80 mg 40 mg 40 mg 5 mg 20 mg 40 -- 45 % 20 mg -- 80 mg 80 mg 5 -- 10 mg 40 mg 46 -- 50 % 40 mg -- -- -- 10 -- 20 mg 80 mg * 50 -- 55 % 80 mg -- -- -- 20 mg -- 56 -- 60 % -- -- -- -- 40 mg -- * 80 - mg dose no longer recommended due to increased risk of rhabdomyolysis Starting dose Starting dose 10 -- 20 mg 20 mg 10 -- 20 mg 40 mg 10 mg ; 5 mg if hypothyroid , > 65 yo , Asian 20 mg If higher LDL reduction goal 40 mg if > 45 % 40 mg if > 25 % 20 mg if > 20 % -- 20 mg if LDL > 190 mg / dL ( 4.87 mmol / L ) 40 mg if > 45 % Optimal timing Anytime Evening With evening meals Anytime Anytime Evening