###Rationale: D i.e. Microaneurysm Microaneurysms are located in the inner nuclear layer and are the earliest and most characteristic ocular lesion Q of diabetic retinopathy.

###Answer: OPTION D IS CORRECT.
###Question: Earliest manifestation of diabetic retinopathy is
###Options:
A. Soft exudates/Cotton wool spot
B. Dot haemorrhage
C. Hard exudates
D. Microaneurysm
