In addition, the high level of reactive oxygen species (ROS) generated by the high metabolic activity of bats could both suppress CoV replication and affect "proofreading". by exoribonuclease, which would create selective pressure and give rise to highly pathogenic viral strains when introduced into a new host.
Isitoshe, kiwango kikubwa cha aina za oksijeni tendaji (ROS) zinazozalishwa kutokana na shughuli nyingi mwilini mwa popo zinaweza kudidimiza mwigo wa CoV na kuathiri mapitio ya Eksoribonuklisi, hivyo kutoa shinikizo la uteuzi kwa ajili ya uzalishaji wa aina ya virusi vilivyo na uwezo mkuu wa kusababisha ugonjwa vinapoingizwa katika mazingira mapya.