In addition, the high level of reactive oxygen species (ROS) generated by the high metabolic activity of bats could both suppress CoV replication and affect "proofreading". by exoribonuclease, which would create selective pressure and give rise to highly pathogenic viral strains when introduced into a new host.
Hata hivyo, inasababisha ugonjwa kuliko virusi vya HCoV vinavyosambazwa kijamii na uwezo wake wa kusababisha ugonjwa ni wa chini kuliko SARS-CoV au MERS-CoV.