In addition to the surfactant and skin protectant, the most complex formulas may contain acids (acetic acid, ascorbic acid, lactic acid) used to regulate the pH, benzoic acid, which has an antimicrobial function, and other protective agents (aloe vera, vitamins, menthol, herbal extracts). Rigorous analysis by the University of Oregon School of Public Health indicated that regular soaps were as effective as antibacterial soaps intended for and containing triclosan, to prevent diseases and eliminate bacteria from the hands.
Kando na dawa ya kulinda ngozi, mchanganyiko changamano unaweza kuwa na asidi (asidi asetiki, asidi askobiki, asidi ya maziwa yaliyochachuka) kama kidhibiti cha pH, asidi inayopambana na viini ya benzoic na vilainishi vingine vya ngozi (aloe vera, vitamini, mentha, dawa kutoka kwenye miti).Uchanganuzi tondoti wa Chuo Kikuu cha Oregon Shule ya Afya ya Umma ulionyesha kuwa sabuni za kawaida hufaa tu kama zilizvyo zile za hadhi ya watumiaji za kupambana na bakteria zilizo na madini ya triclosan katika kuzuia magonjwa na kuondoa bakteria kwenye mikono.