Phylogenetic evidence for natural recombination has been found for both HCoV-HKU1 and HCoV-OC43, as well as CoVs observed in animals, such as SL-CoV and batCoV-HKU9.
Kutokana na hili, virusi vya SARS-CoV-2 hufuata hali inayovuma ya kawaida ya virusi vingine vya HCoV.