Among the accessory proteins of SARS-CoV, ORF8 was considered important in adaptation to humans, since bat viruses related to SARS-CoV were isolated, but encoded divergent ORF8 proteins.
Ndio hii ifanyike, virusi vya HCoV lazima vizalishwe ndani ya binadamu kwa kiwango toshelevu cha kuruhusu mkusanyiko wa mabadiliko yanayoweza kupambana na vigezo vya udhibiti vya mbebaji virusi.