The first strain of HCoV-229E was isolated from the airways of patients with upper respiratory infection in 1966, and subsequently adapted to grow in WI-38 lung cell lines.
Saudi Arabia iliongeza siku ya kafyu katika miji mitakatifu ya Mecca na Medinaili kuendelea kwa siku nzima; awali, muda wa kafyu ulikuwa kati ya saa 3 jioni na 6 asubuhi.