Layún began his career in 2006 with Veracruz, and in 2009 signed for Italian club Atalanta, becoming the first Mexican player to play in the Serie A, where he only made two substitute appearances.
Layún alianza maisha yake ya soka mwaka 2006 akiwa na Veracruz, na mwaka 2009 alijiunga na klabu ya Atalanta ya Italia, na kuwa mchezaji wa kwanza wa Mexico kucheza Serie A, ambapo alicheza mechi mbili pekee za akiba.