You are an AI assistant tasked with analyzing a passage of text to insert retrieval tokens and identify Prefix-intent (PI) and Key Factual Information (KFI). A Prefix-Intent (PI) should be a piece of text that should precede factual information, it must not be only 1 or 2 words. Key Factual Information (KFI) should be meaningful and include important details.

Your goal is to insert a  <|retrieval|> token after it is clear what the intent of the text is (e.g., "The president of the USA is"), but  before the key factual information is stated (e.g., "Joe Biden"). Whenever there is a <|retrieval|> token, we will retrieve the key factual information.

Here is the passage you will be working with:

<passage>
IRF6 Interferon regulatory factor 6 also known as IRF6 is a protein that in humans is encoded by the IRF6 gene. Function This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The function of IRF6 is related to the formation of connective tissue, for example that of the palate. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. In addition, it has been observed that IRF6 gene is under epigenetic regulation by promoter methylation. Pathology A mutation of the IRF6 gene can lead to the autosomal dominant van der Woude syndrome (VWS) or the related popliteal pterygium syndrome (PPS). Van der Woude syndrome can include cleft lip and palate features along with dental anomalies and lip fistulas. In addition, common alleles in IRF6 have also been associated with non-syndromic cases of cleft lip and/or palate through genome-wide association studies and in many candidate gene studies. These disorders are caused by mutations in the IRF6 gene and some of the phenotypic heterogeneity is due to different types of IRF6 mutations. One explanation for this phenotypic variation between syndromes is based on a differential impact on the structure of the dimerized mutant proteins. VWS mutations appear to result in haploinsufficiency while PPS mutations may be dominant negative in nature. The spectrum of mutations in VWS and PPS has been recently summarized. IRF6 has been shown to play a critical role in keratinocyte development. A role for IRF6 in the common forms of cleft lip and palate has also been demonstrated and may explain ~20% of cases of cleft lip only. Variants in IRF6 have yielded consistent evidence of association with syndromic cleft and/or palate across multiple studies. A study by Birnbaum and colleagues in 2009 confirmed the impact of this gene on the etiology of cleft lip and/or palate, and the GENEVA Cleft Consortium study, which studied families from multiple populations, reconfirmed the findings that IRF6 mutations are strongly associated with cleft and/or palate. A role of IRF6 in causing cleft lip and/or palate is further supported by analysis of IRF6 mutant mice which exhibit a hyper-proliferative epidermis that fails to undergo terminal differentiation, leading to multiple epithelial adhesions that can occlude the oral cavity and result in cleft palate. Research on animal models indicate IRF6 determines keratinocyte proliferation and also has a key role in the formation of oral periderm. Recently, through utilization of mouse genetics, gene expression analyses, chromatin immunoprecipitation studies and luciferase reporter assays, it has been shown that IRF6 is a direct target of p63, which underlies several malformation syndromes that include cleft features, and p63 activates IRF6 transcription through the IRF6 enhancer element. Variation in the enhancer element increases susceptibility to cleft lip only. Both cleft lip with or without a cleft palate and cleft palate only features have been seen in families with an IRF6 mutation. In addition, different types of clefts can segregate within the same family. Epigenetics The IRF6 aberrant promoter DNA hypermethylation has been observed associated with cancer onset/progression. Indeed, this improper epigenetic phenomenon has been observed in women affected by Vulvar Squamous cell carcinoma arose from vulver lichen sclerosus. Methylation of the IRF6 promoter may be a marker of cancer risk in patients affected by this disease. Cancer IRF6 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a
</passage>

Follow these steps to complete the task:

1. Inserting retrieval tokens:
   a. Read through the text carefully.
   b. Identify potential Prefix-Intent (PI) sections that consist of a single intent and could serve as a search query. You must not modify the prefix intent and it MUST be part verbatim in the passage. It cannot be single or only a few words.
   c. For each identified PI, evaluate if the following sentence/subsentece that could serve as Key Factual Information (KFI).
   d. Insert <|retrieval|> tokens into the text AFTER the Prefix Intent (PI) and BEFORE key factual information is stated (KFI).
   e. Key Factual information should not intersect with Prefix Intent.

2. Identifying Prefix-Intent (PI) and Key Factual Information (KFI):
   a. For each <|retrieval|> token you've inserted, identify the preceding text as the Prefix-Intent (PI).
   b. Identify the following text, up to the next PI, as the Key Factual Information (KFI).
   c. Ensure that both PI and FI are short subsentences or phrases but not 1 or 2 words.

3. Insert <|start-PI|>,<|end-PI|>, <|start-KFI|>, <|end-KFI|>.
   a. For each identified Prefix Intent (PI), add a start and end special tokens (<|start-PI|>,<|end-PI|>) to quickly identify them.
   b. Do the same for the Key Factual Information (KFI) (<|start-KFI|>, <|end-KFI|>)
   c. Ensure that the very first PI in the passage is preceded by <|start-PI|>.
   d. Double-check that every PI and KFI is properly enclosed in these tags.

4. Describing ideal retrieved information:
   a. Given the Prefix-Intent (PI) and Key Factual Information (KFI), imagine an ideal retriever and enormous corpus. 
   b. Using the retriever and corpus, imagine that you can retrieve information given the Prefix-Intent.  
   c. Describe how that content should look like so it helps generating the Key Factual Information (KFI)


5. Reformulate the Prefix Intent if necessary: Reformulate it to not be impersonal. This means that if the subject it is not identified (e.g. it, he, she) you need to add the appropriate subject so the prefix-intent can be understood by itself. The subject should be changed from the previous information in the passage. Reformulated Prefix should not add any extra information or intent that is not mentioned in the original Prefix Intent.


6. Output format:
   For each pair of Prefix-Intent (PI) and Key Factual Information (KFI) you identify, provide the following output separating each example in a JSON list output. Ensure that it is actually a JSON.

   - Prefix_intent: [Write the Prefix Intent here]
   - Prefix_reformulated: [Write the Prefix Intent reformulated]
   - Key_Factual_Information: [Write the Key Factual Information here]
   - Verification: [Confirm that the KFI can be directly derived from the PI given a strictly connected context]
   - Ideal_Knowledge: [Describe how the ideal retrieved content should look to generate the KFI]
   - Explanation: [Briefly explain how the PI and KFI connect and why you chose to insert the <|retrieval|> token in that position]


7. Final step:
   After you have completed the analysis and provided outputs for all identified PI-KFI pairs, present the original passage with the <|retrieval|> tokens inserted in their appropriate positions

Here's an example of the expected output format:

Passage: Girmal Falls General This waterfall extends to a height of up to 100 feet, making it the highest waterfall of Gujarat. The picturesque beauty of this site makes it popular among visitors and people of the region alike. The water swiftly falls from a great height, creating a fog like condition that’s eye catching. The government of this state is working on many projects to make this place an ideal picnic spot and a tourist attraction. The fall comes to its best form at the time of monsoon and provides an immensely striking appearance. Some of the best natural features of Gujarat can be explored in this place. This place is a nice and refreshing retreat for any traveler.

```json
{ "results" : [
  {
    "Prefix_intent": "Girmal Falls General This waterfall extends to a height of up to",
    "Prefix_reformulated": "What is the height of Girmal Falls?",
    "Key_Factual_Information": "100 feet, making it the highest waterfall of Gujarat",
    "Verification": "The KFI directly provides the height information requested in the PI.",
    "Ideal_Knowledge": "A list of waterfalls in Gujarat, India, with their heights and rankings, specifically mentioning Girmal Falls as the highest at 100 feet.",
    "Explanation": "The PI introduces Girmal Falls and sets up a query about its height, while the KFI provides the specific measurement and its significance. The <|retrieval|> token is inserted to indicate where additional information might be needed to support the factual statement."
  },
  {
    "Prefix_intent": "The water swiftly falls from a great height, creating",
    "Prefix_reformulated": "What does the water falling from Girmal Falls create?",
    "Key_Factual_Information": "a fog like condition that's eye catching",
    "Verification": "The KFI directly describes the effect created by the falling water, as prompted by the PI.",
    "Ideal_Knowledge": "Detailed descriptions of the visual effects created by high waterfalls, including the formation of mist or fog-like conditions due to water droplets in the air.",
    "Explanation": "The PI describes the water falling and sets up a query about its effect, while the KFI provides the specific visual phenomenon created. The <|retrieval|> token is inserted to indicate where additional information might be needed to support the description."
  },
  {
    "Prefix_intent": "The fall comes to its best form at the time of",
    "Prefix_reformulated": "When does Girmal Falls come to its best form?",
    "Key_Factual_Information": "monsoon and provides an immensely striking appearance",
    "Verification": "The KFI directly answers when the waterfall is at its best and describes its appearance, as prompted by the PI.",
    "Ideal_Knowledge": "Information on the seasonal variations of Girmal Falls, highlighting the monsoon season's impact on water flow and visual appeal.",
    "Explanation": "The PI sets up a query about the best time to view the falls, and the KFI provides the specific season and describes the appearance. The <|retrieval|> token is inserted to indicate where additional information about seasonal changes might be needed."
  }],
"Updated_Passage":"<|start-PI|> Girmal Falls General This waterfall extends to a height of up to <|end-PI|> <|retrieval|> <|start-KFI|> 100 feet, making it the highest waterfall of Gujarat <|end-KFI|>. The picturesque beauty of this site makes it popular among visitors and people of the region alike. <|start-PI|> The water swiftly falls from a great height, creating <|end-PI|> <|retrieval|> <|start-KFI|> a fog like condition that’s eye catching <|end-KFI|>. The government of this state is working on many projects to make this place an ideal picnic spot and a tourist attraction. <|start-PI|> The fall comes to its best form at the time of <|end-PI|> <|retrieval|> <|start-KFI|> monsoon and provides an immensely striking appearance <|end-KFI|>. Some of the best natural features of Gujarat can be explored in this place. This place is a nice and refreshing retreat for any traveler."
}

```
8. Final check:
  a. Review the Updated_Passage to ensure all PIs and KFIs are properly tagged.
  b. Verify that the first PI in the passage starts with <|start-PI|>.
  c. Make sure there are no missing or misplaced tags.
 
Remember to analyze the entire passage, identify all relevant PI-KFI pairs, and provide the output for each pair as specified. After completing the analysis, present the original passage with the <|retrieval|> tokens inserted in their appropriate positions as part of a new key in the JSON file. Only Ouput the JSON File.