You are an AI assistant tasked with analyzing a passage of text to insert retrieval tokens and identify Prefix-intent (PI) and Key Factual Information (KFI). A Prefix-Intent (PI) should be a piece of text that should precede factual information, it must not be only 1 or 2 words. Key Factual Information (KFI) should be meaningful and include important details.

Your goal is to insert a  <|retrieval|> token after it is clear what the intent of the text is (e.g., "The president of the USA is"), but  before the key factual information is stated (e.g., "Joe Biden"). Whenever there is a <|retrieval|> token, we will retrieve the key factual information.

Here is the passage you will be working with:

<passage>
cells, suggesting that the parasite use this protein for immune evasion by modulating mucosal T cells. Extending circulating half-life Due to their low molecular mass, ShK and its analogues are prone to rapid renal elimination. In rats, the half-life is ~6 min for ShK-186 and ~11 min for ShK-198, with a clearance rate of ~950 ml/kg·min. In monkeys, the half-life is ~12 min for ShK-186 and ~46 min for ShK-198, with a clearance rate of ~80 ml/kg·min. PEGylation of ShK: Conjugation of polyethylene glycol (PEG) to ShK[Q16K], an ShK analogue, increased its molecular mass and thereby reduced renal clearance and extended plasma half-life to 15 h in mice and 64 h in cynomolgus monkeys. PEGylation can also decrease immunogenicity and protect a peptide from proteolysis and non-specific adsorption to inert surfaces. PEGylated ShK[Q16K] prevented adoptive-transfer experimental autoimmune encephalomyelitis in rats, a model for multiple sclerosis. Conjugation of ShK to larger proteins: The circulating half-life of peptides can be prolonged by coupling them to larger proteins or protein domains. By screening a combinatorial ShK peptide library, novel analogues were identified, which when fused to the C-termini of IgG1-Fc retained picomolar potency, effectively suppressed in vivo delayed type hypersensitivity and exhibited a prolonged circulating half-life. Prolonged effects despite rapid plasma clearance: SPECT/CT imaging studies with a 111In-DOTA-conjugate of ShK-186 in rats and squirrel monkeys revealed a slow release from the injection site and blood levels above the channel blocking dose for 2 and 7 days, respectively. Studies on human peripheral blood T cells showed that a brief exposure to ShK-186 was sufficient to suppress cytokine responses. These findings suggest that ShK-186, despite its short circulating half-life, may have a prolonged therapeutic effect. In rats, the peptide is effective in treating disease in animal models of autoimmune diseases when administered once a day to once in 3 days. In humans, subcutaneous injections twice a week are sufficient to ameliorate disease in patients with plaque psoriasis. Peptide delivery The low molecular mass of ShK and its analogues, combined with their high isoelectric points, makes it unlikely that these peptides will be absorbed from the stomach or intestine following oral administration. Sub-lingual delivery is a possibility. A fluorescent ShK analogue was absorbed into the blood stream at pharmacological concentrations following sublingual administration with a mucoadhesive chitosan-based gel, with or without the penetration enhancer cetrimide. Delivery of the peptide as an aerosol through the lung, or across the skin, or as eye drops are also possibilities. Modulation of T cell function During T cell-activation, calcium enters lymphocytes through store-operated CRAC channels (calcium release activated channel) formed as a complex of Orai and Stim proteins. The rise in intracellular calcium initiates a signaling cascade culminating in cytokine production and proliferation. The Kv1.3 K+ channel and the calcium-activated KCa3.1 K+ channel in T cells promote calcium entry into the cytoplasm through CRAC by providing a counterbalancing cation efflux. Blockade of Kv1.3 depolarizes the membrane potential of T cells, suppresses calcium signaling and IL-2 production, but not IL2-receptor expression. Kv1.3 blockers have no effect on activation pathways that are independent of a rise in intracellular calcium (e.g. anti-CD28, IL-2). Expression of the Kv1.3 and KCa3.1 channels varies during T cell activation and differentiation into memory T cells. When naïve T cells and central memory T cells (TCM) are activated they upregulate KCa3.1 expression to ~500 per cell without significant change in Kv1.3 numbers. In contrast, when terminally differentiated effector memory subsets (TEM, TEMRA [T effector memory re-expressing CD45RA]) are activated, they upregulate Kv1.3 to 1500 per cell without changes in KCa3.1. The Kv1.3 channel number increases and the KCa3.1
</passage>

Follow these steps to complete the task:

1. Inserting retrieval tokens:
   a. Read through the text carefully.
   b. Identify potential Prefix-Intent (PI) sections that consist of a single intent and could serve as a search query. You must not modify the prefix intent and it MUST be part verbatim in the passage. It cannot be single or only a few words.
   c. For each identified PI, evaluate if the following sentence/subsentece that could serve as Key Factual Information (KFI).
   d. Insert <|retrieval|> tokens into the text AFTER the Prefix Intent (PI) and BEFORE key factual information is stated (KFI).
   e. Key Factual information should not intersect with Prefix Intent.

2. Identifying Prefix-Intent (PI) and Key Factual Information (KFI):
   a. For each <|retrieval|> token you've inserted, identify the preceding text as the Prefix-Intent (PI).
   b. Identify the following text, up to the next PI, as the Key Factual Information (KFI).
   c. Ensure that both PI and FI are short subsentences or phrases but not 1 or 2 words.

3. Insert <|start-PI|>,<|end-PI|>, <|start-KFI|>, <|end-KFI|>.
   a. For each identified Prefix Intent (PI), add a start and end special tokens (<|start-PI|>,<|end-PI|>) to quickly identify them.
   b. Do the same for the Key Factual Information (KFI) (<|start-KFI|>, <|end-KFI|>)
   c. Ensure that the very first PI in the passage is preceded by <|start-PI|>.
   d. Double-check that every PI and KFI is properly enclosed in these tags.

4. Describing ideal retrieved information:
   a. Given the Prefix-Intent (PI) and Key Factual Information (KFI), imagine an ideal retriever and enormous corpus. 
   b. Using the retriever and corpus, imagine that you can retrieve information given the Prefix-Intent.  
   c. Describe how that content should look like so it helps generating the Key Factual Information (KFI)


5. Reformulate the Prefix Intent if necessary: Reformulate it to not be impersonal. This means that if the subject it is not identified (e.g. it, he, she) you need to add the appropriate subject so the prefix-intent can be understood by itself. The subject should be changed from the previous information in the passage. Reformulated Prefix should not add any extra information or intent that is not mentioned in the original Prefix Intent.


6. Output format:
   For each pair of Prefix-Intent (PI) and Key Factual Information (KFI) you identify, provide the following output separating each example in a JSON list output. Ensure that it is actually a JSON.

   - Prefix_intent: [Write the Prefix Intent here]
   - Prefix_reformulated: [Write the Prefix Intent reformulated]
   - Key_Factual_Information: [Write the Key Factual Information here]
   - Verification: [Confirm that the KFI can be directly derived from the PI given a strictly connected context]
   - Ideal_Knowledge: [Describe how the ideal retrieved content should look to generate the KFI]
   - Explanation: [Briefly explain how the PI and KFI connect and why you chose to insert the <|retrieval|> token in that position]


7. Final step:
   After you have completed the analysis and provided outputs for all identified PI-KFI pairs, present the original passage with the <|retrieval|> tokens inserted in their appropriate positions

Here's an example of the expected output format:

Passage: Girmal Falls General This waterfall extends to a height of up to 100 feet, making it the highest waterfall of Gujarat. The picturesque beauty of this site makes it popular among visitors and people of the region alike. The water swiftly falls from a great height, creating a fog like condition that’s eye catching. The government of this state is working on many projects to make this place an ideal picnic spot and a tourist attraction. The fall comes to its best form at the time of monsoon and provides an immensely striking appearance. Some of the best natural features of Gujarat can be explored in this place. This place is a nice and refreshing retreat for any traveler.

```json
{ "results" : [
  {
    "Prefix_intent": "Girmal Falls General This waterfall extends to a height of up to",
    "Prefix_reformulated": "What is the height of Girmal Falls?",
    "Key_Factual_Information": "100 feet, making it the highest waterfall of Gujarat",
    "Verification": "The KFI directly provides the height information requested in the PI.",
    "Ideal_Knowledge": "A list of waterfalls in Gujarat, India, with their heights and rankings, specifically mentioning Girmal Falls as the highest at 100 feet.",
    "Explanation": "The PI introduces Girmal Falls and sets up a query about its height, while the KFI provides the specific measurement and its significance. The <|retrieval|> token is inserted to indicate where additional information might be needed to support the factual statement."
  },
  {
    "Prefix_intent": "The water swiftly falls from a great height, creating",
    "Prefix_reformulated": "What does the water falling from Girmal Falls create?",
    "Key_Factual_Information": "a fog like condition that's eye catching",
    "Verification": "The KFI directly describes the effect created by the falling water, as prompted by the PI.",
    "Ideal_Knowledge": "Detailed descriptions of the visual effects created by high waterfalls, including the formation of mist or fog-like conditions due to water droplets in the air.",
    "Explanation": "The PI describes the water falling and sets up a query about its effect, while the KFI provides the specific visual phenomenon created. The <|retrieval|> token is inserted to indicate where additional information might be needed to support the description."
  },
  {
    "Prefix_intent": "The fall comes to its best form at the time of",
    "Prefix_reformulated": "When does Girmal Falls come to its best form?",
    "Key_Factual_Information": "monsoon and provides an immensely striking appearance",
    "Verification": "The KFI directly answers when the waterfall is at its best and describes its appearance, as prompted by the PI.",
    "Ideal_Knowledge": "Information on the seasonal variations of Girmal Falls, highlighting the monsoon season's impact on water flow and visual appeal.",
    "Explanation": "The PI sets up a query about the best time to view the falls, and the KFI provides the specific season and describes the appearance. The <|retrieval|> token is inserted to indicate where additional information about seasonal changes might be needed."
  }],
"Updated_Passage":"<|start-PI|> Girmal Falls General This waterfall extends to a height of up to <|end-PI|> <|retrieval|> <|start-KFI|> 100 feet, making it the highest waterfall of Gujarat <|end-KFI|>. The picturesque beauty of this site makes it popular among visitors and people of the region alike. <|start-PI|> The water swiftly falls from a great height, creating <|end-PI|> <|retrieval|> <|start-KFI|> a fog like condition that’s eye catching <|end-KFI|>. The government of this state is working on many projects to make this place an ideal picnic spot and a tourist attraction. <|start-PI|> The fall comes to its best form at the time of <|end-PI|> <|retrieval|> <|start-KFI|> monsoon and provides an immensely striking appearance <|end-KFI|>. Some of the best natural features of Gujarat can be explored in this place. This place is a nice and refreshing retreat for any traveler."
}

```
8. Final check:
  a. Review the Updated_Passage to ensure all PIs and KFIs are properly tagged.
  b. Verify that the first PI in the passage starts with <|start-PI|>.
  c. Make sure there are no missing or misplaced tags.
 
Remember to analyze the entire passage, identify all relevant PI-KFI pairs, and provide the output for each pair as specified. After completing the analysis, present the original passage with the <|retrieval|> tokens inserted in their appropriate positions as part of a new key in the JSON file. Only Ouput the JSON File.