The structural chromosomal alterations involving 22q13.1 in osteoid osteoma may affect critical genes involved in the regulation of cell proliferation, such as the YWHAH gene.  YWHAH gene codes for a 14-3-3 family members of dimeric phosphoserine -binding proteins that participate in signal transduction and checkpoint control pathways. Their primary function is to inhibit apoptosis. Another gene mapped in this region is PDGFB that codes for a platelet-derived growth factor, a beta polypeptide (simian sarcoma viral v-sis oncogene homolog), a potent mitogen for cells of mesenchymal origin and involved in the transformation process.
What is the relationship between osteoid and osteoma?
<s>[INST] Answer the question truthfully, you are a medical professional. This is the question: What is the relationship between osteoid and osteoma? [/INST] \n The structural chromosomal alterations involving 22q13.1 in osteoid osteoma may affect critical genes involved in the regulation of cell proliferation, such as the YWHAH gene.  YWHAH gene codes for a 14-3-3 family members of dimeric phosphoserine -binding proteins that participate in signal transduction and checkpoint control pathways. Their primary function is to inhibit apoptosis. Another gene mapped in this region is PDGFB that codes for a platelet-derived growth factor, a beta polypeptide (simian sarcoma viral v-sis oncogene homolog), a potent mitogen for cells of mesenchymal origin and involved in the transformation process.</s>