The prognosis depends on the associated and precipitating conditions of pneumomediastinum.  Spontaneous pneumomediastinum has the most favorable prognosis. Spontaneous pneumomediastinum usually resolves by itself, but chronic cases have been reported (>2 months).
What are the natural history, possible complications, and prognosis of Pneumomediastinum?
<s>[INST] Answer the question truthfully, you are a medical professional. This is the question: What are the natural history, possible complications, and prognosis of Pneumomediastinum? [/INST] \n The prognosis depends on the associated and precipitating conditions of pneumomediastinum.  Spontaneous pneumomediastinum has the most favorable prognosis. Spontaneous pneumomediastinum usually resolves by itself, but chronic cases have been reported (>2 months).</s>