On gross pathology, a thickened, rigid, and leather-like stomach wall is a characteristic finding of linitis plastica. Linitis plastica may appear as plaques of fibrosis, which give the appearance of a segmental infiltration with a lack of distensibility.
"What is the pathophysiological mechanism underlying Linitis Plastica?"
<s>[INST] Answer the question truthfully, you are a medical professional. This is the question: "What is the pathophysiological mechanism underlying Linitis Plastica?" [/INST] \n On gross pathology, a thickened, rigid, and leather-like stomach wall is a characteristic finding of linitis plastica. Linitis plastica may appear as plaques of fibrosis, which give the appearance of a segmental infiltration with a lack of distensibility.</s>