Mutations in the FGFR3 gene cause Crouzonodermoskeletal syndrome.  The FGFR3 gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. It remains unclear how a mutation in the FGFR3 gene leads to the characteristic features of Crouzonodermoskeletal syndrome. This genetic change appears to disrupt the normal growth of skull bones and affect skin pigmentation.
What are the genetic changes related to Crouzonodermoskeletal syndrome ?
<s>[INST] Answer the question truthfully, you are a medical professional. This is the question: What are the genetic changes related to Crouzonodermoskeletal syndrome ? [/INST] \n Mutations in the FGFR3 gene cause Crouzonodermoskeletal syndrome.  The FGFR3 gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. It remains unclear how a mutation in the FGFR3 gene leads to the characteristic features of Crouzonodermoskeletal syndrome. This genetic change appears to disrupt the normal growth of skull bones and affect skin pigmentation.</s>