(RS)-dobutamine
Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure. It may also be used in certain types of cardiac stress tests. It is given by IV only, as an injection into a vein or intraosseous as a continuous infusion. The amount of medication needs to be adjusted to the desired effect. Onset of effects is generally seen within 2 minutes. It has a half-life of two minutes. This drug is administered short term and does not continue past 72 hours in a hospital setting. Common side effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection. Use is not recommended in those with idiopathic hypertrophic subaortic stenosis. It primarily works by direct stimulation of β1 receptors, which increases the strength of the heart's contractions, leading to a positive ionotrophic effect. Generally it has little effect on a person's heart rate.Dobutamine was approved for medical use in the United States in 1978. It is available as a generic medication. It was initially made from isoproterenol.
pair of enantiomers
polyphenol medication secondary amine pair of enantiomers