Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to craniofacial-deafness-hand syndrome ?
    ### Response:
    Craniofacial-deafness-hand syndrome is caused by mutations in the PAX3 gene. The PAX3 gene plays a critical role in the formation of tissues and organs during embryonic development. To perform this function, the gene provides instructions for making a protein that attaches (binds) to specific areas of DNA to help control the activity of particular genes.
    