Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital hypothyroidism ?
    ### Response:
    Congenital hypothyroidism can be caused by a variety of factors, only some of which are genetic. The most common cause worldwide is a shortage of iodine in the diet of the mother and the affected infant. Iodine is essential for the production of thyroid hormones.
    