Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Scleroderma ?
    ### Response:
    Scleroderma is an autoimmune disorder that involves changes in the skin, blood vessels, muscles, and internal organs. There are two main types: localized scleroderma, which affects only the skin; and systemic scleroderma, which affects the blood vessels and internal organs, as well as the skin.
    