Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiminicore disease ?
    ### Response:
    Mutations in the RYR1 and SEPN1 genes cause multiminicore disease.  The severe, classic form of multiminicore disease is usually caused by mutations in the SEPN1 gene. This gene provides instructions for making a protein called selenoprotein N. Although its function is unknown, researchers suspect that this protein may play a role in the formation of muscle tissue before birth.
    