Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Angelman syndrome ?
    ### Response:
    Many of the characteristic features of Angelman syndrome result from the loss of function of a gene called UBE3A. People normally inherit one copy of the UBE3A gene from each parent. Both copies of this gene are turned on (active) in many of the body's tissues.
    