Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to esophageal atresia/tracheoesophageal fistula ?
    ### Response:
    Isolated EA/TEF is considered to be a multifactorial condition, which means that multiple gene variations and environmental factors likely contribute to its occurrence. In most cases of isolated EA/TEF, no specific genetic changes or environmental factors have been conclusively determined to be the cause.
    