Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) renal coloboma syndrome ?
    ### Response:
    Renal coloboma syndrome (also known as papillorenal syndrome) is a condition that primarily affects kidney (renal) and eye development. People with this condition typically have kidneys that are small and underdeveloped (hypoplastic), which can lead to end-stage renal disease (ESRD).
    