Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Split hand foot malformation ?
    ### Response:
    What causes split hand foot malformation? Split hand foot malformation may occur as an isolated feature or it may be associated with a genetic syndrome. Researchers believe that a large number of mutations can cause split hand foot malformation. A few of which have been identified: FBXW4 and TP63.
    