Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to methylmalonic acidemia ?
    ### Response:
    Mutations in the MUT, MMAA, MMAB, MMADHC, and MCEE genes cause methylmalonic acidemia. The long term effects of methylmalonic acidemia depend on which gene is mutated and the severity of the mutation.  About 60 percent of methylmalonic acidemia cases are caused by mutations in the MUT gene.
    