Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to nephrogenic diabetes insipidus ?
    ### Response:
    The hereditary form of nephrogenic diabetes insipidus can be caused by mutations in at least two genes. About 90 percent of all cases of hereditary nephrogenic diabetes insipidus result from mutations in the AVPR2 gene. Most of the remaining 10 percent of cases are caused by mutations in the AQP2 gene.
    