Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to fragile X-associated tremor/ataxia syndrome ?
    ### Response:
    Mutations in the FMR1 gene increase the risk of developing FXTAS. The FMR1 gene provides instructions for making a protein called FMRP, which helps regulate the production of other proteins. FMRP plays a role in the development of synapses, which are specialized connections between nerve cells.
    