Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Mitochondrial genetic disorders ?
    ### Response:
    What causes mitochondrial genetic disorders? Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria. Most DNA (hereditary material that is passed from parent to child) is packaged within the nucleus of each cell (known as nuclear DNA).
    