Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to polymicrogyria ?
    ### Response:
    In most people with polymicrogyria, the cause of the condition is unknown. However, researchers have identified several environmental and genetic factors that can be responsible for the disorder. Environmental causes of polymicrogyria include certain infections during pregnancy and a lack of oxygen to the fetus (intrauterine ischemia).
    