Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Netherton syndrome ?
    ### Response:
    Netherton syndrome is caused by mutations in the SPINK5 gene. This gene provides instructions for making a protein called LEKT1. LEKT1 is a type of serine peptidase inhibitor. Serine peptidase inhibitors control the activity of enzymes called serine peptidases, which break down other proteins.
    