Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) triosephosphate isomerase deficiency ?
    ### Response:
    Triosephosphate isomerase deficiency is a disorder characterized by a shortage of red blood cells (anemia), movement problems, increased susceptibility to infection, and muscle weakness that can affect breathing and heart function.  The anemia in this condition begins in infancy.
    