Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Insulin Resistance and Prediabetes ?
    ### Response:
    Although the exact causes of insulin resistance are not completely understood, scientists think the major contributors to insulin resistance are excess weight and physical inactivity.
                
Excess Weight
                
Some experts believe obesity, especially excess fat around the waist, is a primary cause of insulin resistance.
    