Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Meier-Gorlin syndrome ?
    ### Response:
    Meier-Gorlin syndrome can be caused by mutations in one of several genes. Each of these genes, ORC1, ORC4, ORC6, CDT1, and CDC6, provides instructions for making one of a group of proteins known as the pre-replication complex. This complex regulates initiation of the copying (replication) of DNA before cells divide.
    