Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hereditary leiomyomatosis and renal cell cancer ?
    ### Response:
    Mutations in the FH gene cause hereditary leiomyomatosis and renal cell cancer. The FH gene provides instructions for making an enzyme called fumarase (also known as fumarate hydratase). This enzyme participates in an important series of reactions known as the citric acid cycle or Krebs cycle, which allows cells to use oxygen and generate energy.
    