Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to epidermolysis bullosa simplex ?
    ### Response:
    The four major types of epidermolysis bullosa simplex can result from mutations in either the KRT5 or KRT14 gene. These genes provide instructions for making proteins called keratin 5 and keratin 14. These tough, fibrous proteins work together to provide strength and resiliency to the outer layer of the skin (the epidermis).
    