Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) What I need to know about Hirschsprung Disease ?
    ### Response:
    Hirschsprung* disease (HD) is a disease of the large intestine that causes severe constipation or intestinal obstruction. Constipation means stool moves through the intestines slower than usual. Bowel movements occur less often than normal and stools are difficult to pass.
    