Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial adenomatous polyposis ?
    ### Response:
    Mutations in the APC gene cause both classic and attenuated familial adenomatous polyposis. These mutations affect the ability of the cell to maintain normal growth and function. Cell overgrowth resulting from mutations in the APC gene leads to the colon polyps seen in familial adenomatous polyposis.
    