Below is an instruction from Human. Write a response.
    ### Instruction:
    Is Autosomal recessive polycystic kidney disease inherited ?
    ### Response:
    How is autosomal recessive polycystic kidney disease inherited? Autosomal recessive polycystic kidney disease (ARPKD) is inherited in an autosomal recessive manner. This means that an affected individual has two gene alterations (mutations) in the PKHD1 gene, with one mutation inherited from each parent.
    