Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to beta thalassemia ?
    ### Response:
    Mutations in the HBB gene cause beta thalassemia. The HBB gene provides instructions for making a protein called beta-globin. Beta-globin is a component (subunit) of hemoglobin. Hemoglobin consists of four protein subunits, typically two subunits of beta-globin and two subunits of another protein called alpha-globin.
    