Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Char syndrome ?
    ### Response:
    Mutations in the TFAP2B gene cause Char syndrome. This gene provides instructions for making a protein known as transcription factor AP-2. A transcription factor is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes.
    