Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Ehlers-Danlos syndrome ?
    ### Response:
    Mutations in more than a dozen genes have been found to cause Ehlers-Danlos syndrome. The classical type results most often from mutations in either the COL5A1 gene or the COL5A2 gene. Mutations in the TNXB gene have been found in a very small percentage of cases of the hypermobility type (although in most cases, the cause of this type is unknown).
    