Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to focal dermal hypoplasia ?
    ### Response:
    Mutations in the PORCN gene cause focal dermal hypoplasia. This gene provides instructions for making a protein that is responsible for modifying other proteins, called Wnt proteins. Wnt proteins participate in chemical signaling pathways in the body that regulate development of the skin, bones, and other structures before birth.
    