Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pseudoxanthoma elasticum ?
    ### Response:
    Mutations in the ABCC6 gene cause PXE. This gene provides instructions for making a protein called MRP6 (also known as the ABCC6 protein). This protein is found primarily in cells of the liver and kidneys, with small amounts in other tissues, including the skin, stomach, blood vessels, and eyes.
    