Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to North American Indian childhood cirrhosis ?
    ### Response:
    North American Indian childhood cirrhosis results from at least one known mutation in the UTP4 gene. This gene provides instructions for making a protein called cirhin, whose precise function is unknown. Within cells, cirhin is located in a structure called the nucleolus, which is a small region inside the nucleus where ribosomal RNA (rRNA) is produced.
    