Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to fucosidosis ?
    ### Response:
    Mutations in the FUCA1 gene cause fucosidosis. The FUCA1 gene provides instructions for making an enzyme called alpha-L-fucosidase. This enzyme plays a role in the breakdown of complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins) and fats (glycolipids).
    