Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Ohdo syndrome, Maat-Kievit-Brunner type ?
    ### Response:
    The Maat-Kievit-Brunner type of Ohdo syndrome results from mutations in the MED12 gene. This gene provides instructions for making a protein that helps regulate gene activity; it is thought to play an essential role in development both before and after birth.
    