Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation ?
    ### Response:
    LBSL is caused by mutations in the DARS2 gene, which provides instructions for making an enzyme called mitochondrial aspartyl-tRNA synthetase. This enzyme is important in the production (synthesis) of proteins in cellular structures called mitochondria, the energy-producing centers in cells.
    