Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Sandhoff disease ?
    ### Response:
    Mutations in the HEXB gene cause Sandhoff disease. The HEXB gene provides instructions for making a protein that is part of two critical enzymes in the nervous system, beta-hexosaminidase A and beta-hexosaminidase B. These enzymes are located in lysosomes, which are structures in cells that break down toxic substances and act as recycling centers.
    