Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to alpha-1 antitrypsin deficiency ?
    ### Response:
    Mutations in the SERPINA1 gene cause alpha-1 antitrypsin deficiency. This gene provides instructions for making a protein called alpha-1 antitrypsin, which protects the body from a powerful enzyme called neutrophil elastase. Neutrophil elastase is released from white blood cells to fight infection, but it can attack normal tissues (especially the lungs) if not tightly controlled by alpha-1 antitrypsin.
    