Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Pallister-Hall syndrome ?
    ### Response:
    Mutations in the GLI3 gene cause Pallister-Hall syndrome.  The GLI3 gene provides instructions for making a protein that controls gene expression, which is a process that regulates whether genes are turned on or off in particular cells. By interacting with certain genes at specific times during development, the GLI3 protein plays a role in the normal shaping (patterning) of many organs and tissues before birth.
    