Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to optic atrophy type 1 ?
    ### Response:
    Optic atrophy type 1 is caused by mutations in the OPA1 gene. The protein produced from this gene is made in many types of cells and tissues throughout the body. The OPA1 protein is found inside mitochondria, which are the energy-producing centers of cells.
    