Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Dihydrolipoamide dehydrogenase deficiency ?
    ### Response:
    What are the signs and symptoms of Dihydrolipoamide dehydrogenase deficiency? The signs and symptoms of dihydrolipoamide dehydrogenase (DLD) deficiency can vary widely among affected people. Early-onset DLD deficiency typically appears in early infancy with decreased muscle tone (hypotonia), lethargy, and lactic acidosis.
    