Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Peutz-Jeghers syndrome ?
    ### Response:
    Mutations in the STK11 gene (also known as LKB1) cause most cases of Peutz-Jeghers syndrome. The STK11 gene is a tumor suppressor gene, which means that it normally prevents cells from growing and dividing too rapidly or in an uncontrolled way. A mutation in this gene alters the structure or function of the STK11 protein, disrupting its ability to restrain cell division.
    