Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Crigler-Najjar syndrome ?
    ### Response:
    Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome. This gene provides instructions for making the bilirubin uridine diphosphate glucuronosyl transferase (bilirubin-UGT) enzyme, which is found primarily in liver cells and is necessary for the removal of bilirubin from the body.
    