Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Leber hereditary optic neuropathy ?
    ### Response:
    Mutations in the MT-ND1, MT-ND4, MT-ND4L, or MT-ND6 gene can cause LHON. These genes are found in the DNA of cellular structures called mitochondria, which convert the energy from food into a form that cells can use. Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA, known as mitochondrial DNA or mtDNA.
    