Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Mucopolysaccharidosis type I ?
    ### Response:
    What causes mucopolysaccharidosis I (MPS I)? Mutations in the IDUA gene cause MPS I. The IDUA gene provides instructions for producing an enzyme that is involved in the breakdown of large sugar molecules called glycosaminoglycans (GAGs). Mutations in the IDUA gene reduce or completely eliminate the function of the IDUA enzyme.
    