Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Hemoglobin E disease ?
    ### Response:
    What are the signs and symptoms of hemoglobin E disease? Affected individuals can develop mild thalassemia in the first few months of life. While mild splenomegaly and/or anemia can occur, it is generally considered a benign condition. When a person inherits a gene mutation from one of their parents, they are said to be a carrier or have hemoglobin trait.
    