Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Denys-Drash syndrome ?
    ### Response:
    Mutations in the WT1 gene cause Denys-Drash syndrome. The WT1 gene provides instructions for making a protein that regulates the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, the WT1 protein is called a transcription factor.
    