Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Dentinogenesis imperfecta ?
    ### Response:
    What causes dentinogenesis imperfecta? Mutations in the DSPP gene cause dentinogenesis imperfecta. The DSPP gene provides instructions for making three proteins that are essential for normal tooth development. These proteins are involved in the formation of dentin, which is a bone-like substance that makes up the protective middle layer of each tooth.
    