Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Amelogenesis imperfecta ?
    ### Response:
    What causes amelogenesis imperfecta? Amelogenesis imperfecta is caused by mutations in the AMELX, ENAM, and MMP20 genes. These genes provide instructions for making proteins that are essential for normal tooth development. These proteins are involved in the formation of enamel, which is the hard, calcium-rich material that forms the protective outer layer of each tooth.
    