Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Myelodysplastic syndromes ?
    ### Response:
    What causes myelodysplastic syndromes? It is known that the abnormal development of blood cells associated with myelodysplastic syndromes (MDS) develops as the result of a series of somatic genetic changes - mutations that are not inherited that arise after conception - in cells that later become blood cells.
    