Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple sulfatase deficiency ?
    ### Response:
    Multiple sulfatase deficiency is caused by mutations in the SUMF1 gene. This gene provides instructions for making an enzyme called formylglycine-generating enzyme (FGE). This enzyme is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.
    