Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to aniridia ?
    ### Response:
    Aniridia is caused by mutations in the PAX6 gene. The PAX6 gene provides instructions for making a protein that is involved in the early development of the eyes, brain and spinal cord (central nervous system), and the pancreas. Within the brain, the PAX6 protein is involved in the development of a specialized group of brain cells that process smell (the olfactory bulb).
    