Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to actin-accumulation myopathy ?
    ### Response:
    Actin-accumulation myopathy is caused by a mutation in the ACTA1 gene. This gene provides instructions for making a protein called skeletal alpha ()-actin, which is a member of the actin protein family found in skeletal muscles. Actin proteins are important for cell movement and the tensing of muscle fibers (muscle contraction).
    