Below is an instruction from Human. Write a response.
    ### Instruction:
    How to diagnose Wolfram syndrome ?
    ### Response:
    How is Wolfram syndrome diagnosed? A diagnosis of Wolfram syndrome is based on the presence of characteristic signs and symptoms. The identification of a change (mutation) in the WFS1 gene or CISD2 gene confirms the diagnosis. Is genetic testing available for Wolfram syndrome? Yes.
    