Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Juvenile primary lateral sclerosis ?
    ### Response:
    What are the signs and symptoms of Juvenile primary lateral sclerosis? Juvenile primary lateral sclerosis is a rare disorder characterized by progressive weakness and stiffness of muscles in the arms, legs, and face. Symptoms of juvenile primary lateral sclerosis begin in early childhood and progress over a period of 15 to 20 years.
    