Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the complications of Machado-Joseph Disease ?
    ### Response:
    Lyme disease is caused by a bacterial organism that is transmitted to humans via the bite of an infected tick. Most people with Lyme disease develop a characteristic skin rash around the area of the bite. The rash may feel hot to the touch, and vary in size, shape, and color, but it will often have a "bull's eye" appearance (a red ring with a clear center).
    