Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to permanent neonatal diabetes mellitus ?
    ### Response:
    Permanent neonatal diabetes mellitus may be caused by mutations in several genes.  About 30 percent of individuals with permanent neonatal diabetes mellitus have mutations in the KCNJ11 gene. An additional 20 percent of people with permanent neonatal diabetes mellitus have mutations in the ABCC8 gene.
    