Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to X-linked chondrodysplasia punctata 1 ?
    ### Response:
    X-linked chondrodysplasia punctata 1 is caused by genetic changes involving the ARSE gene. This gene provides instructions for making an enzyme called arylsulfatase E. The function of this enzyme is unknown, although it appears to be important for normal skeletal development and is thought to participate in a chemical pathway involving vitamin K.
    