Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Diffuse palmoplantar keratoderma, Bothnian type ?
    ### Response:
    What are the signs and symptoms of Diffuse palmoplantar keratoderma, Bothnian type? The Human Phenotype Ontology provides the following list of signs and symptoms for Diffuse palmoplantar keratoderma, Bothnian type. If the information is available, the table below includes how often the symptom is seen in people with this condition.
    