Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to prothrombin deficiency ?
    ### Response:
    Mutations in the F2 gene cause prothrombin deficiency. The F2 gene provides instructions for making the prothrombin protein (also called coagulation factor II), which plays a critical role in the formation of blood clots in response to injury. Prothrombin is the precursor to thrombin, a protein that initiates a series of chemical reactions to form a blood clot.
    