Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to prekallikrein deficiency ?
    ### Response:
    Prekallikrein deficiency is caused by mutations in the KLKB1 gene, which provides instructions for making a protein called prekallikrein. This protein, when converted to an active form called plasma kallikrein in the blood, is involved in the early stages of blood clotting.
    