Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Langerhans cell histiocytosis ?
    ### Response:
    Somatic mutations in the BRAF gene have been identified in the Langerhans cells of about half of individuals with Langerhans cell histiocytosis. Somatic gene mutations are acquired during a person's lifetime and are present only in certain cells. These changes are not inherited.
    