Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Sotos syndrome ?
    ### Response:
    Mutations in the NSD1 gene are the primary cause of Sotos syndrome, accounting for up to 90 percent of cases. Other genetic causes of this condition have not been identified.  The NSD1 gene provides instructions for making a protein that functions as a histone methyltransferase.
    