Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple pterygium syndrome ?
    ### Response:
    Mutations in the CHRNG gene cause most cases of multiple pterygium syndrome, Escobar type and a smaller percentage of cases of lethal multiple pterygium syndrome. The CHRNG gene provides instructions for making the gamma () protein component (subunit) of the acetylcholine receptor (AChR) protein.
    