Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to phosphoribosylpyrophosphate synthetase superactivity ?
    ### Response:
    Certain mutations in the PRPS1 gene cause PRS superactivity. The PRPS1 gene provides instructions for making an enzyme called phosphoribosyl pyrophosphate synthetase 1, or PRPP synthetase 1. This enzyme helps produce a molecule called phosphoribosyl pyrophosphate (PRPP).
    