Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to osteogenesis imperfecta ?
    ### Response:
    Mutations in the COL1A1, COL1A2, CRTAP, and P3H1 genes cause osteogenesis imperfecta.  Mutations in the COL1A1 and COL1A2 genes are responsible for more than 90 percent of all cases of osteogenesis imperfecta. These genes provide instructions for making proteins that are used to assemble type I collagen.
    