Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to enlarged parietal foramina ?
    ### Response:
    Mutations in the ALX4 gene account for 60 percent of cases of enlarged parietal foramina and mutations in the MSX2 gene account for 40 percent of cases. These genes provide instructions for producing proteins called transcription factors, which are required for proper development throughout the body.
    