Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to adenosine monophosphate deaminase deficiency ?
    ### Response:
    Mutations in the AMPD1 gene cause AMP deaminase deficiency. The AMPD1 gene provides instructions for producing an enzyme called AMP deaminase. This enzyme is found in skeletal muscle, where it plays a role in producing energy within muscle cells. Mutations in the AMPD1 gene disrupt the function of AMP deaminase and impair the muscle cells' ability to produce energy.
    