Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to nephronophthisis ?
    ### Response:
    Nephronophthisis has several genetic causes, which are used to split the condition into distinct types. Nephronophthisis type 1, which is the most common type of the disorder and one cause of juvenile nephronophthisis, results from changes affecting the NPHP1 gene.
    