Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to osteoporosis-pseudoglioma syndrome ?
    ### Response:
    Osteoporosis-pseudoglioma syndrome is caused by mutations in the LRP5 gene. This gene provides instructions for making a protein that participates in a chemical signaling pathway that affects the way cells and tissues develop. In particular, the LRP5 protein helps regulate bone mineral density and plays a critical role in development of the retina.
    