Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Hutchinson-Gilford progeria syndrome ?
    ### Response:
    Mutations in the LMNA gene cause Hutchinson-Gilford progeria syndrome.  The LMNA gene provides instructions for making a protein called lamin A. This protein plays an important role in determining the shape of the nucleus within cells. It is an essential scaffolding (supporting) component of the nuclear envelope, which is the membrane that surrounds the nucleus.
    