Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Mineral and Bone Disorder in Chronic Kidney Disease ?
    ### Response:
    In adults, symptoms of mineral and bone disorder in CKD may not appear until bone changes have taken place for many years. For this reason, people often refer to the disease as a silent crippler. Eventually, a person with the condition may begin to feel bone and joint pain.
    