Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mucopolysaccharidosis type III ?
    ### Response:
    Mutations in the GNS, HGSNAT, NAGLU, and SGSH genes cause MPS III. These genes provide instructions for making enzymes involved in the breakdown of large sugar molecules called glycosaminoglycans (GAGs). GAGs were originally called mucopolysaccharides, which is where this condition gets its name.
    