Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to X-linked sideroblastic anemia ?
    ### Response:
    Mutations in the ALAS2 gene cause X-linked sideroblastic anemia. The ALAS2 gene provides instructions for making an enzyme called erythroid ALA-synthase, which plays a critical role in the production of heme (a component of the hemoglobin protein) in bone marrow.
    