Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to aspartylglucosaminuria ?
    ### Response:
    Mutations in the AGA gene cause aspartylglucosaminuria. The AGA gene provides instructions for producing an enzyme called aspartylglucosaminidase. This enzyme is active in lysosomes, which are structures inside cells that act as recycling centers. Within lysosomes, the enzyme helps break down complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins).
    