Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to succinic semialdehyde dehydrogenase deficiency ?
    ### Response:
    Mutations in the ALDH5A1 gene cause succinic semialdehyde dehydrogenase deficiency. The ALDH5A1 gene provides instructions for producing the succinic semialdehyde dehydrogenase enzyme. This enzyme is involved in the breakdown of a chemical that transmits signals in the brain (neurotransmitter) called gamma-amino butyric acid (GABA).
    