Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) 3-beta-hydroxysteroid dehydrogenase deficiency ?
    ### Response:
    3-beta ()-hydroxysteroid dehydrogenase (HSD) deficiency is an inherited disorder that affects hormone-producing glands including the gonads (ovaries in females and testes in males) and the adrenal glands. The gonads direct sexual development before birth and during puberty.
    