Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to PRICKLE1-related progressive myoclonus epilepsy with ataxia ?
    ### Response:
    PRICKLE1-related progressive myoclonus epilepsy with ataxia is caused by mutations in the PRICKLE1 gene. This gene provides instructions for making a protein called prickle homolog 1, whose function is unknown. Studies suggest that it interacts with other proteins that are critical for brain development and function.
    