Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to glutaric acidemia type I ?
    ### Response:
    Mutations in the GCDH gene cause glutaric acidemia type I.  The GCDH gene provides instructions for making the enzyme glutaryl-CoA dehydrogenase. This enzyme is involved in processing the amino acids lysine, hydroxylysine, and tryptophan.  Mutations in the GCDH gene prevent production of the enzyme or result in the production of a defective enzyme that cannot function.
    