Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial Mediterranean fever ?
    ### Response:
    Mutations in the MEFV gene cause familial Mediterranean fever. The MEFV gene provides instructions for making a protein called pyrin (also known as marenostrin), which is found in white blood cells. This protein is involved in the immune system, helping to regulate the process of inflammation.
    