Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to frontonasal dysplasia ?
    ### Response:
    Mutations in the ALX3 gene cause frontonasal dysplasia type 1, ALX4 gene mutations cause type 2, and ALX1 gene mutations cause type 3. These genes provide instructions for making proteins that are necessary for normal development, particularly of the head and face, before birth.
    