Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to autosomal recessive congenital methemoglobinemia ?
    ### Response:
    Autosomal recessive congenital methemoglobinemia is caused by mutations in the CYB5R3 gene. This gene provides instruction for making an enzyme called cytochrome b5 reductase 3. This enzyme is involved in transferring negatively charged particles called electrons from one molecule to another.
    