Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Wolman disease ?
    ### Response:
    Mutations in the LIPA gene cause Wolman disease.  The LIPA gene provides instructions for producing an enzyme called lysosomal acid lipase. This enzyme is found in the lysosomes (compartments that digest and recycle materials in the cell), where it processes lipids such as cholesteryl esters and triglycerides so they can be used by the body.
    