Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hereditary xanthinuria ?
    ### Response:
    Hereditary xanthinuria type I is caused by mutations in the XDH gene. This gene provides instructions for making an enzyme called xanthine dehydrogenase. This enzyme is involved in the normal breakdown of purines, which are building blocks of DNA and its chemical cousin, RNA.
    