Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to chylomicron retention disease ?
    ### Response:
    Mutations in the SAR1B gene cause chylomicron retention disease. The SAR1B gene provides instructions for making a protein that is involved in transporting chylomicrons within enterocytes, which are cells that line the intestine and absorb nutrients.  SAR1B gene mutations impair the release of chylomicrons into the bloodstream.
    