Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Shapiro syndrome ?
    ### Response:
    Shapiro syndrome is a rare disease affecting about 50 people worldwide that is typically characterized by recurrent episodes of excessive sweating and hypothermia and the agenesis of the corpus callosum. The duration and frequency of the episodes vary from person to person, with some episodes lasting hours to weeks and occurring from hours to years; the reason for the variations in the episodes is not yet known.
    