Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to infantile-onset ascending hereditary spastic paralysis ?
    ### Response:
    Infantile-onset ascending hereditary spastic paralysis is caused by mutations in the ALS2 gene. This gene provides instructions for making the alsin protein. Alsin is produced in a wide range of tissues, with highest amounts in the brain, particularly in motor neurons.
    