Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spondylothoracic dysostosis ?
    ### Response:
    The MESP2 gene provides instructions for a protein that plays a critical role in the development of vertebrae. Specifically, it is involved in separating vertebrae from one another during early development, a process called somite segmentation. Mutations in the MESP2 gene prevent the production of any protein or lead to the production of an abnormally short, nonfunctional protein.
    