Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Alpers' Disease ?
    ### Response:
    Alpers' disease is a progressive, neurodevelopmental, mitochondrial DNA depletion syndrome characterized by three co-occurring clinical symptoms: psychomotor regression (dementia); seizures; and liver disease. It is an autosomal recessive disease caused by mutation in the gene for the mitochondrial DNA polymerase POLG.
    