Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to epidermolysis bullosa with pyloric atresia ?
    ### Response:
    EB-PA can be caused by mutations in the ITGA6, ITGB4, and PLEC genes. These genes provide instructions for making proteins with critical roles in the skin and digestive tract.  ITGB4 gene mutations are the most common cause of EB-PA; these mutations are responsible for about 80 percent of all cases.
    