Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spinal and bulbar muscular atrophy ?
    ### Response:
    Spinal and bulbar muscular atrophy results from a particular type of mutation in the AR gene. This gene provides instructions for making a protein called an androgen receptor. This receptor attaches (binds) to a class of hormones called androgens, which are involved in male sexual development.
    