Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to isolated Pierre Robin sequence ?
    ### Response:
    Changes in the DNA near the SOX9 gene are the most common genetic cause of isolated Pierre Robin sequence. It is likely that changes in other genes, some of which have not been identified, also cause isolated Pierre Robin sequence.  The SOX9 gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development.
    