Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to palmoplantar keratoderma with deafness ?
    ### Response:
    Palmoplantar keratoderma with deafness can be caused by mutations in the GJB2 or MT-TS1 genes.  The GJB2 gene provides instructions for making a protein called gap junction beta 2, more commonly known as connexin 26. Connexin 26 is a member of the connexin protein family.
    