Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to triosephosphate isomerase deficiency ?
    ### Response:
    Mutations in the TPI1 gene cause triosephosphate isomerase deficiency. This gene provides instructions for making an enzyme called triosephosphate isomerase 1. This enzyme is involved in a critical energy-producing process known as glycolysis. During glycolysis, the simple sugar glucose is broken down to produce energy for cells.
    