Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Hereditary diffuse leukoencephalopathy with spheroids ?
    ### Response:
    What causes hereditary diffuse leukoencephalopathy with spheroids (HDLS)? HDLS is caused by mutations in the CSF1R gene. This gene provides instructions for making a protein called colony stimulating factor 1 receptor (CSF-1 receptor), which is found in the outer membrane of certain types of cells.
    