Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial glucocorticoid deficiency ?
    ### Response:
    Mutations in the MC2R, MRAP, and NNT genes account for the majority of cases of familial glucocorticoid deficiency; mutations in other genes, some known and some unidentified, can also cause this condition.  The MC2R gene provides instructions for making a protein called adrenocorticotropic hormone (ACTH) receptor, which is found primarily in the adrenal glands.
    