Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to autoimmune lymphoproliferative syndrome ?
    ### Response:
    Mutations in the FAS gene cause ALPS in approximately 75 percent of affected individuals. The FAS gene provides instructions for making a protein involved in cell signaling that results in the self-destruction of cells (apoptosis).  When the immune system is turned on (activated) to fight an infection, large numbers of lymphocytes are produced.
    