Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to benign recurrent intrahepatic cholestasis ?
    ### Response:
    Mutations in the ATP8B1 gene cause benign recurrent intrahepatic cholestasis type 1 (BRIC1), and mutations in the ABCB11 gene cause benign recurrent intrahepatic cholestasis type 2 (BRIC2). These two genes are involved in the release (secretion) of bile, a fluid produced by the liver that helps digest fats.
    