Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to renal tubular dysgenesis ?
    ### Response:
    Mutations in the ACE, AGT, AGTR1, or REN gene can cause renal tubular dysgenesis. These genes are involved in the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body and plays a role in kidney development before birth.
    