Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pachyonychia congenita ?
    ### Response:
    Mutations in several genes, including KRT6A, KRT6B, KRT6C, KRT16, and KRT17, can cause pachyonychia congenita. All of these genes provide instructions for making tough, fibrous proteins called keratins. These proteins form networks that provide strength and resilience to the tissues that make up the skin, hair, and nails.
    