Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Branchiootorenal syndrome ?
    ### Response:
    What causes branchiootorenal syndrome? Mutations in the genes, EYA1, SIX1, and SIX5, are known to cause branchiootorenal syndrome. About 40 percent of people with this condition have a mutation in the EYA1 gene. SIX1 and SIX5 mutations are much less common causes of the disorder.
    