Below is an instruction from Human. Write a response.
    ### Instruction:
    How many people are affected by hypophosphatasia ?
    ### Response:
    Severe forms of hypophosphatasia affect an estimated 1 in 100,000 newborns. Milder cases, such as those that appear in childhood or adulthood, probably occur more frequently.  Hypophosphatasia has been reported worldwide in people of various ethnic backgrounds.
    