Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to MyD88 deficiency ?
    ### Response:
    MyD88 deficiency is caused by mutations in the MYD88 gene, which provides instructions for making a protein that plays an important role in stimulating the immune system to respond to bacterial infection. The MyD88 protein is part of a signaling pathway that is involved in early recognition of pathogens and the initiation of inflammation to fight infection.
    