Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to lissencephaly with cerebellar hypoplasia ?
    ### Response:
    LCH can be caused by mutations in the RELN or TUBA1A gene. The RELN gene provides instructions for making a protein called reelin. In the developing brain, reelin turns on (activates) a signaling pathway that triggers nerve cells (neurons) to migrate to their proper locations.
    