Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome ?
    ### Response:
    Polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE syndrome) is characterized by excessive accumulation of amniotic fluid that surrounds the baby in the uterus during pregnancy (polyhydramnios), abnormally large, heavy, and usually malfunctioning brain (megalencephaly), seizures and intellectual disability.
    