Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Paget disease of bone ?
    ### Response:
    A combination of genetic and environmental factors likely play a role in causing Paget disease of bone. Researchers have identified changes in several genes that increase the risk of the disorder. Other factors, including infections with certain viruses, may be involved in triggering the disease in people who are at risk.
    