Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Cerebro-Oculo-Facio-Skeletal Syndrome (COFS) ?
    ### Response:
    Cerebro-oculo-facio-skeletal syndrome (COFS) is a pediatric, genetic, degenerative disorder that involves the brain and the spinal cord. It is characterized by craniofacial and skeletal abnormalities, severely reduced muscle tone, and impairment of reflexes.
    