Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to autosomal dominant vitreoretinochoroidopathy ?
    ### Response:
    ADVIRC is caused by mutations in the BEST1 gene. The protein produced from this gene, called bestrophin-1, is thought to play a critical role in normal vision. Bestrophin-1 is found in a thin layer of cells at the back of the eye called the retinal pigment epithelium.
    