Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Adiposis dolorosa ?
    ### Response:
    What causes adiposis dolorosa? The exact cause of adiposis dolorosa remains unknown. While possible causes have been suggested, none have been confirmed. These include long-term treatment with high-dose corticosteroids; endocrine system abnormalities; and changes in fatty acid or carbohydrate metabolism.
    