Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Camurati-Engelmann disease ?
    ### Response:
    Mutations in the TGFB1 gene cause Camurati-Engelmann disease. The TGFB1 gene provides instructions for producing a protein called transforming growth factor beta-1 (TGF-1). The TGF-1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis).
    