Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to paroxysmal extreme pain disorder ?
    ### Response:
    Mutations in the SCN9A gene cause paroxysmal extreme pain disorder. The SCN9A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.7. Sodium channels transport positively charged sodium atoms (sodium ions) into cells and play a key role in a cell's ability to generate and transmit electrical signals.
    