Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to myopathy with deficiency of iron-sulfur cluster assembly enzyme ?
    ### Response:
    Myopathy with deficiency of iron-sulfur cluster assembly enzyme is caused by mutations in the ISCU gene. This gene provides instructions for making a protein called the iron-sulfur cluster assembly enzyme. As its name suggests, this enzyme is involved in the formation of clusters of iron and sulfur atoms (Fe-S clusters).
    