Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 3-beta-hydroxysteroid dehydrogenase deficiency ?
    ### Response:
    Mutations in the HSD3B2 gene cause 3-HSD deficiency. The HSD3B2 gene provides instructions for making the 3-HSD enzyme. This enzyme is found in the gonads and adrenal glands. The 3-HSD enzyme is involved in the production of many hormones, including cortisol, aldosterone, androgens, and estrogen.
    