Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple cutaneous and mucosal venous malformations ?
    ### Response:
    Mutations in the TEK gene (also called the TIE2 gene) cause VMCM. The TEK gene provides instructions for making a protein called TEK receptor tyrosine kinase. This receptor protein triggers chemical signals needed for forming blood vessels (angiogenesis) and maintaining their structure.
    