Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) 3-hydroxy-3-methylglutaryl-CoA lyase deficiency ?
    ### Response:
    3-hydroxy-3-methylglutaryl-CoA lyase deficiency (also known as HMG-CoA lyase deficiency) is an uncommon inherited disorder in which the body cannot process a particular protein building block (amino acid) called leucine. Additionally, the disorder prevents the body from making ketones, which are used for energy during periods without food (fasting).
    