Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Gillespie syndrome ?
    ### Response:
    Gillespie syndrome can be caused by mutations in the PAX6 gene. The PAX6 gene provides instructions for making a protein that is involved in early development, including the development of the eyes and brain. The PAX6 protein attaches (binds) to specific regions of DNA and regulates the activity of other genes.
    