Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Ellis-van Creveld syndrome ?
    ### Response:
    Ellis-van Creveld syndrome can be caused by mutations in the EVC or EVC2 gene. Little is known about the function of these genes, although they appear to play important roles in cell-to-cell signaling during development. In particular, the proteins produced from the EVC and EVC2 genes are thought to help regulate the Sonic Hedgehog signaling pathway.
    