Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Rothmund-Thomson syndrome ?
    ### Response:
    Mutations in the RECQL4 gene cause about two-thirds of all cases of Rothmund-Thomson syndrome. This gene provides instructions for making one member of a protein family called RecQ helicases. Helicases are enzymes that bind to DNA and temporarily unwind the two spiral strands (double helix) of the DNA molecule.
    