Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to factor V deficiency ?
    ### Response:
    Factor V deficiency is usually caused by mutations in the F5 gene, which provides instructions for making a protein called coagulation factor V. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury.
    