Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Dominant dystrophic epidermolysis bullosa ?
    ### Response:
    What causes dominant dystrophic epidermolysis bullosa? Dominant dystrophic epidermolysis bullosa (DDEB) is caused by mutations in the COL7A1 gene. The COL7A1 gene provides instructions for making a protein that is used to assemble type VII collagen. Collagen gives structure and strength to connective tissues, such as skin, tendons, and ligaments, throughout the body.
    