Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to neurofibromatosis type 1 ?
    ### Response:
    Mutations in the NF1 gene cause neurofibromatosis type 1.  The NF1 gene provides instructions for making a protein called neurofibromin. This protein is produced in many cells, including nerve cells and specialized cells surrounding nerves (oligodendrocytes and Schwann cells).
    