Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to ichthyosis with confetti ?
    ### Response:
    Mutations in the KRT10 gene cause ichthyosis with confetti. This gene provides instructions for making a protein called keratin 10, which is found in cells called keratinocytes in the outer layer of the skin (the epidermis). In the fluid-filled space inside these cells (the cytoplasm), this tough, fibrous protein attaches to another keratin protein (produced from a different gene) to form fibers called intermediate filaments.
    