Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Primary hyperoxaluria type 2 ?
    ### Response:
    What are the signs and symptoms of Primary hyperoxaluria type 2? Primary hyperoxaluria type 2 is characterized by recurrent nephrolithiasis (deposition of calcium oxalate in the kidney and urinary tract), nephrocalcinosis (deposition of calcium oxalate in the kidney tissue), and end-stage renal disease (ESRD).
    