Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to megalencephalic leukoencephalopathy with subcortical cysts ?
    ### Response:
    Mutations in the MLC1 gene cause megalencephalic leukoencephalopathy with subcortical cysts type 1; this type accounts for 75 percent of all cases. The MLC1 gene provides instructions for producing a protein that is made primarily in the brain. The MLC1 protein is found in astroglial cells, which are a specialized form of brain cells called glial cells.
    