Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Hirschsprung disease ?
    ### Response:
    Isolated Hirschsprung disease can result from mutations in one of several genes, including the RET, EDNRB, and EDN3 genes. However, the genetics of this condition appear complex and are not completely understood. While a mutation in a single gene sometimes causes the condition, mutations in multiple genes may be required in some cases.
    