Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to systemic scleroderma ?
    ### Response:
    Researchers have identified variations in several genes that may influence the risk of developing systemic scleroderma. The most commonly associated genes belong to a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria).
    