Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Tangier disease ?
    ### Response:
    Mutations in the ABCA1 gene cause Tangier disease. This gene provides instructions for making a protein that releases cholesterol and phospholipids from cells. These substances are used to make HDL, which transports them to the liver.  Mutations in the ABCA1 gene prevent the release of cholesterol and phospholipids from cells.
    