Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to argininosuccinic aciduria ?
    ### Response:
    Mutations in the ASL gene cause argininosuccinic aciduria.  Argininosuccinic aciduria belongs to a class of genetic diseases called urea cycle disorders. The urea cycle is a sequence of reactions that occur in liver cells. It processes excess nitrogen, generated when protein is used by the body, to make a compound called urea that is excreted by the kidneys.
    