Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to arginine:glycine amidinotransferase deficiency ?
    ### Response:
    Mutations in the GATM gene cause arginine:glycine amidinotransferase deficiency. The GATM gene provides instructions for making the enzyme arginine:glycine amidinotransferase. This enzyme participates in the two-step production (synthesis) of the compound creatine from the protein building blocks (amino acids) glycine, arginine, and methionine.
    