Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mitochondrial trifunctional protein deficiency ?
    ### Response:
    Mutations in the HADHA and HADHB genes cause mitochondrial trifunctional protein deficiency. These genes each provide instructions for making part of an enzyme complex called mitochondrial trifunctional protein. This enzyme complex functions in mitochondria, the energy-producing centers within cells.
    