Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pantothenate kinase-associated neurodegeneration ?
    ### Response:
    Mutations in the PANK2 gene cause pantothenate kinase-associated neurodegeneration.  The PANK2 gene provides instructions for making an enzyme called pantothenate kinase 2. This enzyme is active in mitochondria, the energy-producing centers within cells, where it plays a critical role in the formation of a molecule called coenzyme A.
    