Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial dysautonomia ?
    ### Response:
    Mutations in the IKBKAP gene cause familial dysautonomia.  The IKBKAP gene provides instructions for making a protein called IKK complex-associated protein (IKAP). This protein is found in a variety of cells throughout the body, including brain cells.  Nearly all individuals with familial dysautonomia have two copies of the same IKBKAP gene mutation in each cell.
    