Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to gnathodiaphyseal dysplasia ?
    ### Response:
    Gnathodiaphyseal dysplasia is caused by mutations in the ANO5 gene, which provides instructions for making a protein called anoctamin-5. While the specific function of this protein is not well understood, it belongs to a family of proteins, called anoctamins, that act as chloride channels.
    