Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Ochoa syndrome ?
    ### Response:
    Ochoa syndrome can be caused by mutations in the HPSE2 gene. This gene provides instructions for making a protein called heparanase 2. The function of this protein is not well understood.  Mutations in the HPSE2 gene that cause Ochoa syndrome result in changes in the heparanase 2 protein that likely prevent it from functioning.
    