Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) phosphoribosylpyrophosphate synthetase superactivity ?
    ### Response:
    Phosphoribosylpyrophosphate synthetase superactivity (PRS superactivity) is characterized by the overproduction and accumulation of uric acid (a waste product of normal chemical processes) in the blood and urine. The overproduction of uric acid can lead to gout, which is arthritis caused by an accumulation of uric acid crystals in the joints.
    