Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to paramyotonia congenita ?
    ### Response:
    Mutations in the SCN4A gene cause paramyotonia congenita. This gene provides instructions for making a protein that is critical for the normal function of skeletal muscle cells. For the body to move normally, skeletal muscles must tense (contract) and relax in a coordinated way.
    