Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 2-methylbutyryl-CoA dehydrogenase deficiency ?
    ### Response:
    Mutations in the ACADSB gene cause 2-methylbutyryl-CoA dehydrogenase deficiency.  The ACADSB gene provides instructions for making an enzyme called 2-methylbutyryl-CoA dehydrogenase that helps process the amino acid isoleucine. Mutations in the ACADSB gene reduce or eliminate the activity of this enzyme.
    