Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Huntington disease-like syndrome ?
    ### Response:
    In about one percent of people with the characteristic features of Huntington disease, no mutation in the HD gene has been identified. Mutations in the PRNP, JPH3, and TBP genes have been found to cause the signs and symptoms in some of these individuals. HDL1 is caused by mutations in the PRNP gene, while HDL2 results from mutations in JPH3.
    