Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Loeys-Dietz syndrome ?
    ### Response:
    Loeys-Dietz syndrome is a connective tissue disorder that causes aortic aneurysms, widely spaced eyes (hypertelorism), cleft palate and/or split uvula (the little piece of flesh that hangs down in the back of the mouth) and twisting or spiraled arteries (arterial tortuosity).
    