Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Coffin-Lowry syndrome ?
    ### Response:
    Mutations in the RPS6KA3 gene cause Coffin-Lowry syndrome. This gene provides instructions for making a protein that is involved in signaling within cells. Researchers believe that this protein helps control the activity of other genes and plays an important role in the brain.
    