Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to microcephalic osteodysplastic primordial dwarfism type II ?
    ### Response:
    Mutations in the PCNT gene cause MOPDII. The PCNT gene provides instructions for making a protein called pericentrin. Within cells, this protein is located in structures called centrosomes. Centrosomes play a role in cell division and the assembly of microtubules.
    