Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Unverricht-Lundborg disease ?
    ### Response:
    Mutations in the CSTB gene cause Unverricht-Lundborg disease. The CSTB gene provides instructions for making a protein called cystatin B. This protein reduces the activity of enzymes called cathepsins. Cathepsins help break down certain proteins in the lysosomes (compartments in the cell that digest and recycle materials).
    