Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to adenylosuccinate lyase deficiency ?
    ### Response:
    All forms of adenylosuccinate lyase deficiency are caused by mutations in the ADSL gene. This gene provides instructions for making an enzyme called adenylosuccinate lyase, which performs two steps in the process that produces purine nucleotides. These nucleotides are building blocks of DNA, its chemical cousin RNA, and molecules such as ATP that serve as energy sources in the cell.
    