Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to GM3 synthase deficiency ?
    ### Response:
    Mutations in the ST3GAL5 gene have been found to cause GM3 synthase deficiency. This gene provides instructions for making an enzyme called GM3 synthase, which carries out a chemical reaction that is the first step in the production of molecules called gangliosides.
    