Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Leber congenital amaurosis ?
    ### Response:
    Leber congenital amaurosis can result from mutations in at least 14 genes, all of which are necessary for normal vision. These genes play a variety of roles in the development and function of the retina. For example, some of the genes associated with this disorder are necessary for the normal development of light-detecting cells called photoreceptors.
    