Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to laryngo-onycho-cutaneous syndrome ?
    ### Response:
    LOC syndrome is caused by mutations in the LAMA3 gene, which provides instructions for making one part (subunit) of a protein called laminin 332. This protein is made up of three subunits, called alpha, beta, and gamma. The LAMA3 gene carries instructions for the alpha subunit; the beta and gamma subunits are produced from other genes.
    