Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) 1q21.1 microdeletion ?
    ### Response:
    1q21.1 microdeletion is a chromosomal change in which a small piece of chromosome 1 is deleted in each cell. The deletion occurs on the long (q) arm of the chromosome in a region designated q21.1. This chromosomal change increases the risk of delayed development, intellectual disability, physical abnormalities, and neurological and psychiatric problems.
    