Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Tay-Sachs Disease ?
    ### Response:
    Tay-Sachs disease is a inherited metabolic disease caused by the harmful buildup of lipids (fatty materials such as oils and acids) in various cells and tissues in the body. It is part of a group of genetic disorders called the GM2 gangliosidoses. Tay-Sachs and its variant form are caused by a deficiency in the enzyme hexosaminidase A.
    