Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) holocarboxylase synthetase deficiency ?
    ### Response:
    Holocarboxylase synthetase deficiency is an inherited disorder in which the body is unable to use the vitamin biotin effectively. This disorder is classified as a multiple carboxylase deficiency, a group of disorders characterized by impaired activity of certain enzymes that depend on biotin.
    