Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Ghosal hematodiaphyseal dysplasia ?
    ### Response:
    Ghosal hematodiaphyseal dysplasia results from mutations in the TBXAS1 gene. This gene provides instructions for making an enzyme called thromboxane A synthase 1, which acts as part of a chemical signaling pathway involved in normal blood clotting (hemostasis).
    