Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to desmoid tumor ?
    ### Response:
    Mutations in the CTNNB1 gene or the APC gene cause desmoid tumors. CTNNB1 gene mutations account for around 85 percent of sporadic desmoid tumors. APC gene mutations cause desmoid tumors associated with familial adenomatous polyposis as well as 10 to 15 percent of sporadic desmoid tumors.
    