Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) nephronophthisis ?
    ### Response:
    Nephronophthisis is a disorder that affects the kidneys. It is characterized by inflammation and scarring (fibrosis) that impairs kidney function. These abnormalities lead to increased urine production (polyuria), excessive thirst (polydipsia), general weakness, and extreme tiredness (fatigue).
    