Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Moyamoya disease ?
    ### Response:
    What causes Moyamoya disease? In some families, risk for moyamoya disease is inherited. Changes in the RNF213 gene have been associated with the condition. There are other gene changes involved in moyamoya disease, that remain to be found. Factors such as infection or inflammation, likely also play a role in the condition's development in these families.
    