Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hypermanganesemia with dystonia, polycythemia, and cirrhosis ?
    ### Response:
    Mutations in the SLC30A10 gene cause HMDPC. This gene provides instructions for making a protein that transports manganese across cell membranes. Manganese is important for many cellular functions, but large amounts are toxic, particularly to brain and liver cells.
    