Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to acute promyelocytic leukemia ?
    ### Response:
    The mutation that causes acute promyelocytic leukemia involves two genes, the PML gene on chromosome 15 and the RARA gene on chromosome 17. A rearrangement of genetic material (translocation) between chromosomes 15 and 17, written as t(15;17), fuses part of the PML gene with part of the RARA gene.
    