Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to fragile XE syndrome ?
    ### Response:
    Fragile XE syndrome is caused by mutations in the AFF2 gene. This gene provides instructions for making a protein whose function is not well understood. Some studies show that the AFF2 protein can attach (bind) to DNA and help control the activity of other genes.
    