Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Anophthalmia plus syndrome ?
    ### Response:
    What are the signs and symptoms of Anophthalmia plus syndrome? Anophthalmia plus syndrome (APS) may involve malformations in multiple organs of the body including the eyes, ears, nose, face, mouth, brain, sacral vertebrae, meninges (tissue that lines the outer part of the brain and spinal cord), abdominal wall, heart, digits (fingers and toes), and endocrine system.
    