Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Fabry disease ?
    ### Response:
    Fabry disease is caused by mutations in the GLA gene. This gene provides instructions for making an enzyme called alpha-galactosidase A. This enzyme is active in lysosomes, which are structures that serve as recycling centers within cells. Alpha-galactosidase A normally breaks down a fatty substance called globotriaosylceramide.
    