Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to granulomatosis with polyangiitis ?
    ### Response:
    The genetic basis of GPA is not well understood. Having a particular version of the HLA-DPB1 gene is the strongest genetic risk factor for developing this condition, although several other genes, some of which have not been identified, may be involved. It is likely that a combination of genetic and environmental factors lead to GPA.
    