Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Langer mesomelic dysplasia ?
    ### Response:
    Langer mesomelic dysplasia results from changes involving the SHOX gene. The protein produced from this gene plays a role in bone development and is particularly important for the growth and maturation of bones in the arms and legs. The most common cause of Langer mesomelic dysplasia is a deletion of the entire SHOX gene.
    