Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to essential thrombocythemia ?
    ### Response:
    The JAK2 and CALR genes are the most commonly mutated genes in essential thrombocythemia. The MPL, THPO, and TET2 genes can also be altered in this condition. The JAK2, MPL, and THPO genes provide instructions for making proteins that promote the growth and division (proliferation) of blood cells.
    