Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 21-hydroxylase deficiency ?
    ### Response:
    Mutations in the CYP21A2 gene cause 21-hydroxylase deficiency. The CYP21A2 gene provides instructions for making an enzyme called 21-hydroxylase. This enzyme is found in the adrenal glands, where it plays a role in producing hormones called cortisol and aldosterone.
    