Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to oral-facial-digital syndrome ?
    ### Response:
    Only one gene, OFD1, has been associated with oral-facial-digital syndrome. Mutations in this gene cause oral-facial-digital syndrome type I. OFD1 gene mutations were also found in an affected family whose disorder was classified as type VII; however, researchers now believe that type VII is the same as type I.
    