Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes GM1 gangliosidosis ?
    ### Response:
    What causes GM1 gangliosidosis? All three types of GM1 gangliosidosis are caused by mutations (changes) in the GLB1 gene. This gene gives the body instructions to make an enzyme called beta-galactosidase (-galactosidase), which plays an important role in the brain.
    