Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to fumarase deficiency ?
    ### Response:
    The FH gene provides instructions for making an enzyme called fumarase (also known as fumarate hydratase). Fumarase participates in an important series of reactions known as the citric acid cycle or Krebs cycle, which allows cells to use oxygen and generate energy.
    