Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 17-beta hydroxysteroid dehydrogenase 3 deficiency ?
    ### Response:
    Mutations in the HSD17B3 gene cause 17-beta hydroxysteroid dehydrogenase 3 deficiency. The HSD17B3 gene provides instructions for making an enzyme called 17-beta hydroxysteroid dehydrogenase 3. This enzyme is active in the testes, where it helps to produce testosterone from a precursor hormone called androstenedione.
    