Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Pyruvate dehydrogenase deficiency ?
    ### Response:
    Pyruvate dehydrogenase deficiency is metabolic disorder associated with abnormal function of the mitochondria in cells, thus depriving the body of energy. Progressive neurological symptoms usually start in infancy but may be evident at birth, or in later childhood; these symptoms may include developmental delay, intermittent ataxia, poor muscle tone (hypotonia), abnormal eye movements, or seizures.
    