Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to ophthalmo-acromelic syndrome ?
    ### Response:
    Mutations in the SMOC1 gene cause ophthalmo-acromelic syndrome. The SMOC1 gene provides instructions for making a protein called secreted modular calcium-binding protein 1 (SMOC-1). This protein is found in basement membranes, which are thin, sheet-like structures that support cells in many tissues and help anchor cells to one another during embryonic development.
    