Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Nijmegen breakage syndrome ?
    ### Response:
    Mutations in the NBN gene cause Nijmegen breakage syndrome. The NBN gene provides instructions for making a protein called nibrin. This protein is involved in several critical cellular functions, including the repair of damaged DNA. Nibrin interacts with two other proteins as part of a larger protein complex.
    