Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spinal muscular atrophy with progressive myoclonic epilepsy ?
    ### Response:
    SMA-PME is caused by mutations in the ASAH1 gene. This gene provides instructions for making an enzyme called acid ceramidase. This enzyme is found in lysosomes, which are cell compartments that digest and recycle materials. Within lysosomes, acid ceramidase breaks down fats called ceramides into a fat called sphingosine and a fatty acid.
    