Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to horizontal gaze palsy with progressive scoliosis ?
    ### Response:
    HGPPS is caused by mutations in the ROBO3 gene. This gene provides instructions for making a protein that is important for the normal development of certain nerve pathways in the brain. These include motor nerve pathways, which transmit information about voluntary muscle movement, and sensory nerve pathways, which transmit information about sensory input (such as touch, pain, and temperature).
    