Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to proopiomelanocortin deficiency ?
    ### Response:
    POMC deficiency is caused by mutations in the POMC gene, which provides instructions for making the proopiomelanocortin protein. This protein is cut (cleaved) into smaller pieces called peptides that have different functions in the body. One of these peptides, ACTH, stimulates the release of another hormone called cortisol from the adrenal glands.
    