Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to maple syrup urine disease ?
    ### Response:
    Mutations in the BCKDHA, BCKDHB, and DBT genes can cause maple syrup urine disease. These three genes provide instructions for making proteins that work together as a complex. The protein complex is essential for breaking down the amino acids leucine, isoleucine, and valine, which are present in many kinds of food, particularly protein-rich foods such as milk, meat, and eggs.
    