Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to von Willebrand disease ?
    ### Response:
    Mutations in the VWF gene cause von Willebrand disease. The VWF gene provides instructions for making a blood clotting protein called von Willebrand factor, which is essential for the formation of blood clots. After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss.
    