Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Silver syndrome ?
    ### Response:
    Mutations in the BSCL2 gene cause Silver syndrome. The BSCL2 gene provides instructions for making a protein called seipin, whose function is unknown. The BSCL2 gene is active (expressed) in cells throughout the body, particularly in nerve cells that control muscle movement (motor neurons) and in brain cells.
    