Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Knobloch syndrome ?
    ### Response:
    Mutations in the COL18A1 gene can cause Knobloch syndrome. The COL18A1 gene provides instructions for making a protein that forms collagen XVIII, which is found in the basement membranes of tissues throughout the body. Basement membranes are thin, sheet-like structures that separate and support cells in these tissues.
    