Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to choroideremia ?
    ### Response:
    Mutations in the CHM gene cause choroideremia. The CHM gene provides instructions for producing the Rab escort protein-1 (REP-1). As an escort protein, REP-1 attaches to molecules called Rab proteins within the cell and directs them to the membranes of various cell compartments (organelles).
    