Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Glanzmann thrombasthenia ?
    ### Response:
    Mutations in the ITGA2B or ITGB3 gene cause Glanzmann thrombasthenia. These genes provide instructions for making the two parts (subunits) of a receptor protein called integrin alphaIIb/beta3 (IIb3). This protein is abundant on the surface of platelets. Platelets are small cell fragments that circulate in blood and are an essential component of blood clots.
    