Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency ?
    ### Response:
    Mutations in the HADHA gene cause LCHAD deficiency. The HADHA gene provides instructions for making part of an enzyme complex called mitochondrial trifunctional protein. This enzyme complex functions in mitochondria, the energy-producing centers within cells.
    