Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Jacobsen syndrome ?
    ### Response:
    Jacobsen syndrome is caused by a deletion of genetic material at the end of the long (q) arm of chromosome 11. The size of the deletion varies among affected individuals, with most affected people missing 5 million to 16 million DNA building blocks (also written as 5 Mb to 16 Mb).
    