Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Schimke immuno-osseous dysplasia ?
    ### Response:
    Mutations in the SMARCAL1 gene increase the risk of Schimke immuno-osseous dysplasia. The SMARCAL1 gene provides instructions for producing a protein whose specific function is unknown. The SMARCAL1 protein can attach (bind) to chromatin, which is the complex of DNA and protein that packages DNA into chromosomes.
    