Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Transmissible Spongiform Encephalopathies ?
    ### Response:
    Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare degenerative brain disorders characterized by tiny holes that give the brain a "spongy" appearance. These holes can be seen when brain tissue is viewed under a microscope.
    