Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Wolfram syndrome ?
    ### Response:
    Mutations in the WFS1 gene cause more than 90 percent of Wolfram syndrome type 1 cases. This gene provides instructions for producing a protein called wolframin that is thought to regulate the amount of calcium in cells. A proper calcium balance is important for many different cellular functions, including cell-to-cell communication, the tensing (contraction) of muscles, and protein processing.
    