Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Cole disease ?
    ### Response:
    Cole disease is a disorder that affects the skin. People with this disorder have areas of unusually light-colored skin (hypopigmentation), typically on the arms and legs, and spots of thickened skin on the palms of the hands and the soles of the feet (punctate palmoplantar keratoderma).
    