Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to beta-ureidopropionase deficiency ?
    ### Response:
    Beta-ureidopropionase deficiency is caused by mutations in the UPB1 gene, which provides instructions for making an enzyme called beta-ureidopropionase. This enzyme is involved in the breakdown of molecules called pyrimidines, which are building blocks of DNA and its chemical cousin RNA.
    