Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Osteogenesis imperfecta ?
    ### Response:
    What causes osteogenesis imperfecta? Osteogenesis imperfecta (OI) may be caused by changes (mutations) in any of several genes. OI is most commonly due to a mutation in either the COL1A1 or COL1A2 gene, causing OI types I through IV. These genes play a role in how the body makes collagen, a material that helps to strengthen the bones.
    