Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to antiphospholipid syndrome ?
    ### Response:
    The genetic cause of antiphospholipid syndrome is unknown. This condition is associated with the presence of three abnormal immune proteins (antibodies) in the blood: lupus anticoagulant, anticardiolipin, and anti-B2 glycoprotein I. Antibodies normally bind to specific foreign particles and germs, marking them for destruction, but the antibodies in antiphospholipid syndrome attack normal human proteins.
    