Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to campomelic dysplasia ?
    ### Response:
    Mutations in or near the SOX9 gene cause campomelic dysplasia. This gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development. The SOX9 protein regulates the activity of other genes, especially those that are important for development of the skeleton and reproductive organs.
    