Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to anencephaly ?
    ### Response:
    Anencephaly is a complex condition that is likely caused by the interaction of multiple genetic and environmental factors. Some of these factors have been identified, but many remain unknown.  Changes in dozens of genes in individuals with anencephaly and in their mothers may influence the risk of developing this type of neural tube defect.
    