Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Leigh syndrome ?
    ### Response:
    Leigh syndrome can be caused by mutations in one of over 30 different genes. In humans, most genes are found in DNA in the cell's nucleus, called nuclear DNA. However, some genes are found in DNA in specialized structures in the cell called mitochondria. This type of DNA is known as mitochondrial DNA (mtDNA).
    