Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Bart-Pumphrey syndrome ?
    ### Response:
    Bart-Pumphrey syndrome is characterized by nail and skin abnormalities and hearing loss.  People with Bart-Pumphrey syndrome typically have a white discoloration of the nails (leukonychia); the nails may also be thick and crumbly. Affected individuals often have wart-like (verrucous) skin growths called knuckle pads on the knuckles of the fingers and toes.
    