Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple epiphyseal dysplasia ?
    ### Response:
    Mutations in the COMP, COL9A1, COL9A2, COL9A3, or MATN3 gene can cause dominant multiple epiphyseal dysplasia. These genes provide instructions for making proteins that are found in the spaces between cartilage-forming cells (chondrocytes). These proteins interact with each other and play an important role in cartilage and bone formation.
    