Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to ataxia with oculomotor apraxia ?
    ### Response:
    Mutations in the APTX and SETX genes cause ataxia with oculomotor apraxia types 1 and 2, respectively. These genes provide instructions for making proteins that are involved in DNA repair.  Mutations in the APTX or SETX gene decrease the amount of functional protein that is available to repair damaged DNA, which leads to the accumulation of breaks in DNA.
    