Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to prolidase deficiency ?
    ### Response:
    Prolidase deficiency is caused by mutations in the PEPD gene. This gene provides instructions for making the enzyme prolidase, also called peptidase D. Prolidase helps divide certain dipeptides, which are molecules composed of two protein building blocks (amino acids).
    