Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to infantile neuronal ceroid lipofuscinosis ?
    ### Response:
    Mutations in the PPT1 gene cause most cases of infantile NCL. The PPT1 gene provides instructions for making an enzyme called palmitoyl-protein thioesterase 1. This enzyme is active in cell compartments called lysosomes, which digest and recycle different types of molecules.
    