Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Heart Valve Disease ?
    ### Response:
    Major Signs and Symptoms
                
The main sign of heart valve disease is an unusual heartbeat sound called a heart murmur. Your doctor can hear a heart murmur with a stethoscope.
                
However, many people have heart murmurs without having heart valve disease or any other heart problems.
    