Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Pol III-related leukodystrophy ?
    ### Response:
    Pol III-related leukodystrophy is caused by mutations in the POLR3A or POLR3B gene. These genes provide instructions for making the two largest parts (subunits) of an enzyme called RNA polymerase III. This enzyme is involved in the production (synthesis) of ribonucleic acid (RNA), a chemical cousin of DNA.
    