Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spastic paraplegia type 3A ?
    ### Response:
    Mutations in the ATL1 gene cause spastic paraplegia type 3A. The ATL1 gene provides instructions for producing a protein called atlastin-1. Atlastin-1 is produced primarily in the brain and spinal cord (central nervous system), particularly in nerve cells (neurons) that extend down the spinal cord (corticospinal tracts).
    