Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Kufs disease ?
    ### Response:
    Mutations in the CLN6 or PPT1 gene cause Kufs disease type A, and mutations in the DNAJC5 or CTSF gene cause Kufs disease type B. Most of the proteins or enzymes produced from these genes are involved in breaking down proteins or clearing unneeded materials from cells.
    