Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to restless legs syndrome ?
    ### Response:
    Restless legs syndrome likely results from a combination of genetic and environmental factors, many of which are unknown.  Studies suggest that restless legs syndrome is related to a shortage (deficiency) of iron in certain parts of the brain. Iron is involved in several critical activities in brain cells, including the production of a chemical messenger (neurotransmitter) called dopamine.
    