Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to ataxia neuropathy spectrum ?
    ### Response:
    Ataxia neuropathy spectrum is caused by mutations in the POLG gene or, rarely, the C10orf2 gene.  The POLG gene provides instructions for making one part, the alpha subunit, of a protein called polymerase gamma (pol ). The C10orf2 gene provides instructions for making a protein called Twinkle.
    