Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Kidney Disease ?
    ### Response:
    What the Kidneys Do You have two kidneys. They are bean-shaped and about the size of a fist. They are located in the middle of your back, on the left and right of your spine, just below your rib cage. The kidneys filter your blood, removing wastes and extra water to make urine.
    