Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Ehlers-Danlos syndrome ?
    ### Response:
    What causes Ehlers-Danlos syndrome? Ehlers-Danlos syndrome can be caused by changes (mutations) in several different genes (COL5A1, COL5A2, COL1A1, COL3A1, TNXB, PLOD1, COL1A2, and ADAMTS2). However, the underlying genetic cause is unknown in some families.
    