Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency ?
    ### Response:
    Mutations in the CYP11B1 gene cause CAH due to 11-beta-hydroxylase deficiency. The CYP11B1 gene provides instructions for making an enzyme called 11-beta-hydroxylase. This enzyme is found in the adrenal glands, where it helps produce hormones called cortisol and corticosterone.
    