Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Renpenning syndrome ?
    ### Response:
    Renpenning syndrome is caused by mutations in the PQBP1 gene. This gene provides instructions for making a protein called polyglutamine-binding protein 1. This protein attaches (binds) to stretches of multiple copies of a protein building block (amino acid) called glutamine in certain other proteins.
    