Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to microphthalmia with linear skin defects syndrome ?
    ### Response:
    Mutations in the HCCS gene or a deletion of genetic material that includes the HCCS gene cause microphthalmia with linear skin defects syndrome. The HCCS gene carries instructions for producing an enzyme called holocytochrome c-type synthase. This enzyme is active in many tissues of the body and is found in the mitochondria, the energy-producing centers within cells.
    