Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Leydig cell hypoplasia ?
    ### Response:
    Mutations in the LHCGR gene cause Leydig cell hypoplasia. The LHCGR gene provides instructions for making a protein called the luteinizing hormone/chorionic gonadotropin receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks.
    