Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to surfactant dysfunction ?
    ### Response:
    Surfactant dysfunction is caused by mutations in one of several genes, including SFTPB, SFTPC, and ABCA3. Each of these genes is involved in the production of surfactant. The production and release of surfactant is a complex process. The phospholipids and proteins that make up surfactant are packaged in cellular structures known as lamellar bodies.
    