Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to preeclampsia ?
    ### Response:
    The specific causes of preeclampsia are not well understood. In pregnancy, blood volume normally increases to support the fetus, and the mother's body must adjust to handle this extra fluid. In some women the body does not react normally to the fluid changes of pregnancy, leading to the problems with high blood pressure and urine production in the kidneys that occur in preeclampsia.
    