Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital sucrase-isomaltase deficiency ?
    ### Response:
    Mutations in the SI gene cause congenital sucrase-isomaltase deficiency. The SI gene provides instructions for producing the enzyme sucrase-isomaltase. This enzyme is found in the small intestine and is responsible for breaking down sucrose and maltose into their simple sugar components.
    