Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to CHARGE syndrome ?
    ### Response:
    Mutations in the CHD7 gene cause more than half of all cases of CHARGE syndrome. The CHD7 gene provides instructions for making a protein that most likely regulates gene activity (expression) by a process known as chromatin remodeling. Chromatin is the complex of DNA and protein that packages DNA into chromosomes.
    