Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital myasthenic syndrome ?
    ### Response:
    Mutations in many genes can cause congenital myasthenic syndrome. Mutations in the CHRNE gene are responsible for more than half of all cases. A large number of cases are also caused by mutations in the RAPSN, CHAT, COLQ, and DOK7 genes. All of these genes provide instructions for producing proteins that are involved in the normal function of the neuromuscular junction.
    