Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Currarino triad ?
    ### Response:
    What causes Currarino triad? Currarino triad is caused by mutations in the MNX1 gene in nearly all familial and 30% of sporadic cases. These mutations in the gene are called loss of function mutations because the gene can no longer produce working (functional) protein.
    