Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Schizencephaly ?
    ### Response:
    What causes schizencephaly? The exact cause of schizencephaly is unknown. A small number of people with schizencephaly are found to have changes (mutations) in one of four genes: EMX2, SIX3, SHH, and COL4A1. Rarely, schizencephaly can affect more than one family member.
    