Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Gitelman syndrome ?
    ### Response:
    Gitelman syndrome is usually caused by mutations in the SLC12A3 gene. Less often, the condition results from mutations in the CLCNKB gene. The proteins produced from these genes are involved in the kidneys' reabsorption of salt (sodium chloride or NaCl) from urine back into the bloodstream.
    