Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Hajdu-Cheney syndrome ?
    ### Response:
    Hajdu-Cheney syndrome is associated with mutations in the NOTCH2 gene. This gene provides instructions for making a receptor called Notch2. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. When a ligand binds to the Notch2 receptor, it triggers signals that are important for the normal development and function of many different types of cells.
    