Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Lynch syndrome ?
    ### Response:
    Variations in the MLH1, MSH2, MSH6, PMS2, or EPCAM gene increase the risk of developing Lynch syndrome.  The MLH1, MSH2, MSH6, and PMS2 genes are involved in the repair of mistakes that occur when DNA is copied in preparation for cell division (a process called DNA replication).
    