Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Cornelia de Lange syndrome ?
    ### Response:
    Cornelia de Lange syndrome can result from mutations in at least five genes: NIPBL, SMC1A, HDAC8, RAD21, and SMC3. Mutations in the NIPBL gene have been identified in more than half of all people with this condition; mutations in the other genes are much less common.
    