Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to carbamoyl phosphate synthetase I deficiency ?
    ### Response:
    Mutations in the CPS1 gene cause carbamoyl phosphate synthetase I deficiency. The CPS1 gene provides instructions for making the enzyme carbamoyl phosphate synthetase I. This enzyme participates in the urea cycle, which is a sequence of biochemical reactions that occurs in liver cells.
    