Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to lymphangioleiomyomatosis ?
    ### Response:
    Mutations in the TSC1 gene or, more commonly, the TSC2 gene, cause LAM. The TSC1 and TSC2 genes provide instructions for making the proteins hamartin and tuberin, respectively. Within cells, these two proteins likely help regulate cell growth and size. The proteins act as tumor suppressors, which normally prevent cells from growing and dividing too fast or in an uncontrolled way.
    