Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to ethylmalonic encephalopathy ?
    ### Response:
    Mutations in the ETHE1 gene cause ethylmalonic encephalopathy.  The ETHE1 gene provides instructions for making an enzyme that plays an important role in energy production. It is active in mitochondria, which are the energy-producing centers within cells. Little is known about the enzyme's exact function, however.
    