Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Townes-Brocks syndrome ?
    ### Response:
    Townes-Brocks syndrome is a genetic condition characterized by an obstruction of the anal opening (imperforate anus), abnormally shaped ears, and hand malformations that most often affect the thumbs. Most affected individuals have at least two of these three main features.
    