Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Ollier disease ?
    ### Response:
    In most people with Ollier disease, the disorder is caused by mutations in the IDH1 or IDH2 gene. These genes provide instructions for making enzymes called isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2, respectively. These enzymes convert a compound called isocitrate to another compound called 2-ketoglutarate.
    