Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hypochromic microcytic anemia with iron overload ?
    ### Response:
    Mutations in the SLC11A2 gene cause hypochromic microcytic anemia with iron overload. The SLC11A2 gene provides instructions for making a protein called divalent metal transporter 1 (DMT1). The DMT1 protein is found in all tissues, where its primary role is to transport positively charged iron atoms (ions) within cells.
    