Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to polycythemia vera ?
    ### Response:
    Mutations in the JAK2 and TET2 genes are associated with polycythemia vera. Although it remains unclear exactly what initiates polycythemia vera, researchers believe that it begins when mutations occur in the DNA of a hematopoietic stem cell. These stem cells are located in the bone marrow and have the potential to develop into red blood cells, white blood cells, and platelets.
    