Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spastic paraplegia type 7 ?
    ### Response:
    Mutations in the SPG7 gene cause spastic paraplegia type 7. The SPG7 gene provides instructions for producing a protein called paraplegin. Located within the inner membrane of the energy-producing centers of cells (mitochondria), paraplegin is one of the proteins that form a complex called the m-AAA protease.
    