Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Manitoba oculotrichoanal syndrome ?
    ### Response:
    Manitoba oculotrichoanal syndrome is caused by mutations in the FREM1 gene. The FREM1 gene provides instructions for making a protein that is involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues.
    