Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to infantile-onset spinocerebellar ataxia ?
    ### Response:
    Mutations in the C10orf2 gene cause IOSCA. The C10orf2 gene provides instructions for making two very similar proteins called Twinkle and Twinky. These proteins are found in the mitochondria, which are structures within cells that convert the energy from food into a form that cells can use.
    