Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) GRACILE syndrome ?
    ### Response:
    GRACILE syndrome is a severe disorder that begins before birth. GRACILE stands for the condition's characteristic features: growth retardation, aminoaciduria, cholestasis, iron overload, lactic acidosis, and early death.  In GRACILE syndrome, growth before birth is slow (intrauterine growth retardation).
    