Below is an instruction from Human. Write a response.
    ### Instruction:
    Who is at risk for Peripheral Arterial Disease (P.A.D.)? ?
    ### Response:
    Smoking is the main risk factor for P.A.D. Your risk of P.A.D. increases four times if you smoke. Smoking also raises your risk for other diseases, such as coronary heart disease (CHD). On average, smokers who develop P.A.D. have symptoms 10 years earlier than nonsmokers who develop P.
    