Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Alzheimer disease ?
    ### Response:
    Most cases of early-onset Alzheimer disease are caused by gene mutations that can be passed from parent to child. Researchers have found that this form of the disorder can result from mutations in one of three genes: APP, PSEN1, or PSEN2. When any of these genes is altered, large amounts of a toxic protein fragment called amyloid beta peptide are produced in the brain.
    