Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to inclusion body myopathy with early-onset Paget disease and frontotemporal dementia ?
    ### Response:
    Mutations in the VCP gene cause IBMPFD. The VCP gene provides instructions for making an enzyme called valosin-containing protein, which has a wide variety of functions within cells. One of its most critical jobs is to help break down (degrade) proteins that are abnormal or no longer needed.
    