Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to holocarboxylase synthetase deficiency ?
    ### Response:
    Mutations in the HLCS gene cause holocarboxylase synthetase deficiency.  The HLCS gene provides instructions for making an enzyme called holocarboxylase synthetase. This enzyme is important for the effective use of biotin, a B vitamin found in foods such as liver, egg yolks, and milk.
    