Below is an instruction from Human. Write a response.
    ### Instruction:
    How to diagnose Harlequin ichthyosis ?
    ### Response:
    Can harlequin ichthyosis be diagnosed before birth using amniocentesis or chorionic villus sampling? Yes, harlequin ichthyosis can be diagnosed before birth using either amniocentesis or chorionic villus sampling. Both of these procedures are used to obtain a sample of fetal DNA, which can be tested for mutations in the ABCA12 gene.
    