Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to ankyloblepharon-ectodermal defects-cleft lip/palate syndrome ?
    ### Response:
    AEC syndrome is caused by mutations in the TP63 gene. This gene provides instructions for making a protein known as p63, which plays an essential role in early development. The p63 protein is a transcription factor, which means that it attaches (binds) to DNA and controls the activity of particular genes.
    