Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Schwartz-Jampel syndrome ?
    ### Response:
    Schwartz-Jampel syndrome is caused by mutations in the HSPG2 gene. This gene provides instructions for making a protein known as perlecan. This protein is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.
    