Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Mucopolysaccharidosis type I ?
    ### Response:
    Mucopolysaccharidosis I (MPS I) is a condition that affects many parts of the body. It is a progressively debilitating disorder; however, the rate of progression varies among affected individuals. MPS I is caused by mutations in the IDUA gene. These mutations lead to reduced levels or the complete lack of the IDUA enzyme.
    