Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Crohn disease ?
    ### Response:
    Crohn disease is related to chromosomes 5 and 10.  Variations of the ATG16L1, IRGM, and NOD2 genes increase the risk of developing Crohn disease.  The IL23R gene is associated with Crohn disease.  A variety of genetic and environmental factors likely play a role in causing Crohn disease.
    