Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Pyruvate kinase deficiency ?
    ### Response:
    What are the signs and symptoms of Pyruvate kinase deficiency? The signs and symptoms of pyruvate kinase deficiency may vary greatly from person to person, but usually include the breakdown of red blood cells resulting in hemolytic anemia, a yellowing of the whites of the eyes (icterus), fatigue, lethargy, recurrent gallstones, jaundice, and pale skin (pallor).
    