Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to alpha-methylacyl-CoA racemase deficiency ?
    ### Response:
    AMACR deficiency is caused by mutations in the AMACR gene. This gene provides instructions for making an enzyme called alpha-methylacyl-CoA racemase (AMACR).  The AMACR enzyme is found in the energy-producing centers in cells (mitochondria) and in cell structures called peroxisomes.
    