Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cri-du-chat syndrome ?
    ### Response:
    Cri-du-chat syndrome is caused by a deletion of the end of the short (p) arm of chromosome 5. This chromosomal change is written as 5p-. The size of the deletion varies among affected individuals; studies suggest that larger deletions tend to result in more severe intellectual disability and developmental delay than smaller deletions.
    