Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Pachydermoperiostosis ?
    ### Response:
    Pachydermoperiostosis is a rare disorder characterized by clubbing of the fingers and toes; thickening of the skin of the face (pachyderma); excessive sweating (hyperhidrosis); and new bone formation associated with joint pain. Other features may include congenital heart disease and delayed closure of fontanelles.
    