Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Canavan disease ?
    ### Response:
    Mutations in the ASPA gene cause Canavan disease. The ASPA gene provides instructions for making an enzyme called aspartoacylase. This enzyme normally breaks down a compound called N-acetyl-L-aspartic acid (NAA), which is predominantly found in neurons in the brain.
    