Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Gaucher disease ?
    ### Response:
    Mutations in the GBA gene cause Gaucher disease. The GBA gene provides instructions for making an enzyme called beta-glucocerebrosidase. This enzyme breaks down a fatty substance called glucocerebroside into a sugar (glucose) and a simpler fat molecule (ceramide).
    