Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cerebral cavernous malformation ?
    ### Response:
    Mutations in at least three genes, KRIT1 (also known as CCM1), CCM2, and PDCD10 (also known as CCM3), cause familial cerebral cavernous malformations.  The precise functions of these genes are not fully understood. Studies show that the proteins produced from these genes are found in the junctions connecting neighboring blood vessel cells.
    