Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to IRAK-4 deficiency ?
    ### Response:
    IRAK-4 deficiency is caused by mutations in the IRAK4 gene, which provides instructions for making a protein that plays an important role in stimulating the immune system to respond to infection. The IRAK-4 protein is part of a signaling pathway that is involved in early recognition of foreign invaders (pathogens) and the initiation of inflammation to fight infection.
    