Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial male-limited precocious puberty ?
    ### Response:
    Familial male-limited precocious puberty can be caused by mutations in the LHCGR gene. This gene provides instructions for making a receptor protein called the luteinizing hormone/chorionic gonadotropin receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks.
    