Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Lujan syndrome ?
    ### Response:
    Lujan syndrome is caused by at least one mutation in the MED12 gene. This gene provides instructions for making a protein that helps regulate gene activity; it is involved in many aspects of early development. The MED12 gene mutation that causes Lujan syndrome changes a single protein building block (amino acid) in the MED12 protein.
    