Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cytogenetically normal acute myeloid leukemia ?
    ### Response:
    CN-AML is classified as "cytogenetically normal" based on the type of genetic changes involved in its development. Cytogenetically normal refers to the fact that this form of acute myeloid leukemia is not associated with large chromosomal abnormalities. About half of people with acute myeloid leukemia have this form of the condition; the other half have genetic changes that alter large regions of certain chromosomes.
    