Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to T-cell immunodeficiency, congenital alopecia, and nail dystrophy ?
    ### Response:
    T-cell immunodeficiency, congenital alopecia, and nail dystrophy results from mutations in the FOXN1 gene. This gene provides instructions for making a protein that is important for development of the skin, hair, nails, and immune system. Studies suggest that this protein helps guide the formation of hair follicles and the growth of fingernails and toenails.
    