Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Hereditary leiomyomatosis and renal cell cancer ?
    ### Response:
    What causes hereditary leiomyomatosis and renal cell cancer? Hereditary leiomyomatosis and renal cell cancer (HLRCC) is caused by changes (mutations) in the FH gene. This gene gives the body instructions for making an enzyme called fumarase which is needed for a series of reactions that lets cells use oxygen and energy (the citric acid cycle, or Krebs cycle).
    