Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to autosomal recessive hyper-IgE syndrome ?
    ### Response:
    AR-HIES is usually caused by mutations in the DOCK8 gene. The protein produced from this gene plays a critical role in the survival and function of several types of immune system cells. One of the protein's functions is to help maintain the structure and integrity of immune cells called T cells and NK cells, which recognize and attack foreign invaders, particularly as these cells travel to sites of infection within the body.
    