Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes ?
    ### Response:
    What are the signs and symptoms of Mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes? The signs and symptoms of MELAS often appear in childhood following a period of normal development. Early symptoms may include muscle weakness and pain, recurrent headaches, loss of appetite, vomiting, and seizures.
    