Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mucopolysaccharidosis type VII ?
    ### Response:
    Mutations in the GUSB gene cause MPS VII. This gene provides instructions for producing the beta-glucuronidase (-glucuronidase) enzyme, which is involved in the breakdown of large sugar molecules called glycosaminoglycans (GAGs). GAGs were originally called mucopolysaccharides, which is where this condition gets its name.
    