Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial cold autoinflammatory syndrome ?
    ### Response:
    Mutations in the NLRP3 and NLRP12 genes cause familial cold autoinflammatory syndrome. The NLRP3 gene (also known as CIAS1) provides instructions for making a protein called cryopyrin, and the NLRP12 gene provides instructions for making the protein monarch-1.
    