Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to dihydropyrimidine dehydrogenase deficiency ?
    ### Response:
    Dihydropyrimidine dehydrogenase deficiency is caused by mutations in the DPYD gene. This gene provides instructions for making an enzyme called dihydropyrimidine dehydrogenase, which is involved in the breakdown of molecules called uracil and thymine. Uracil and thymine are pyrimidines, which are one type of nucleotide.
    