Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hypophosphatasia ?
    ### Response:
    Mutations in the ALPL gene cause hypophosphatasia.  The ALPL gene provides instructions for making an enzyme called alkaline phosphatase. This enzyme plays an essential role in mineralization of the skeleton and teeth. Mutations in the ALPL gene lead to the production of an abnormal version of alkaline phosphatase that cannot participate effectively in the mineralization process.
    