Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Lowe syndrome ?
    ### Response:
    Mutations in the OCRL gene cause Lowe syndrome. The OCRL gene provides instructions for making an enzyme that helps modify fat (lipid) molecules called membrane phospholipids. By controlling the levels of specific membrane phospholipids, the OCRL enzyme helps regulate the transport of certain substances to and from the cell membrane.
    