Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Bloom syndrome ?
    ### Response:
    Mutations in the BLM gene cause Bloom syndrome. The BLM gene provides instructions for making a member of a protein family called RecQ helicases. Helicases are enzymes that attach (bind) to DNA and unwind the two spiral strands (double helix) of the DNA molecule.
    