Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to geleophysic dysplasia ?
    ### Response:
    Geleophysic dysplasia results from mutations in the ADAMTSL2 gene. This gene provides instructions for making a protein whose function is unclear. The protein is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.
    