Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pyridoxine-dependent epilepsy ?
    ### Response:
    Mutations in the ALDH7A1 gene cause pyridoxine-dependent epilepsy. The ALDH7A1 gene provides instructions for making an enzyme called -aminoadipic semialdehyde (-AASA) dehydrogenase, also known as antiquitin. This enzyme is involved in the breakdown of the protein building block (amino acid) lysine in the brain.
    