Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to alpha-mannosidosis ?
    ### Response:
    Mutations in the MAN2B1 gene cause alpha-mannosidosis. This gene provides instructions for making the enzyme alpha-mannosidase. This enzyme works in the lysosomes, which are compartments that digest and recycle materials in the cell. Within lysosomes, the enzyme helps break down complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins).
    