Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Y chromosome infertility ?
    ### Response:
    As its name suggests, this form of infertility is caused by changes in the Y chromosome. People normally have 46 chromosomes in each cell. Two of the 46 chromosomes are sex chromosomes, called X and Y. Females have two X chromosomes (46,XX), and males have one X chromosome and one Y chromosome (46,XY).
    