Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to sialuria ?
    ### Response:
    Mutations in the GNE gene cause sialuria. The GNE gene provides instructions for making an enzyme found in cells and tissues throughout the body. This enzyme is involved in a chemical pathway that produces sialic acid, which is a simple sugar that attaches to the ends of more complex molecules on the surface of cells.
    