Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mannose-binding lectin deficiency ?
    ### Response:
    Relatively common mutations in the MBL2 gene can lead to mannose-binding lectin deficiency. This gene provides instructions for making a protein that assembles into a complex called mannose-binding lectin. Functional mannose-binding lectins are made up of two to six protein groups called trimers, which are each composed of three of the protein pieces (subunits) produced from the MBL2 gene.
    