Below is an instruction from Human. Write a response.
    ### Instruction:
    What to do for What I need to know about Hirschsprung Disease ?
    ### Response:
    - Hirschsprung disease (HD) is a disease of the large intestine that causes severe constipation or intestinal obstruction. People with HD are born with it.  - The large intestine, which includes the colon and rectum, is the last part of the digestive tract.
    