Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to primary sclerosing cholangitis ?
    ### Response:
    Primary sclerosing cholangitis is thought to arise from a combination of genetic and environmental factors. Researchers believe that genetic changes play a role in this condition because it often occurs in several members of a family and because immediate family members of someone with primary sclerosing cholangitis have an increased risk of developing the condition.
    