Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cherubism ?
    ### Response:
    Mutations in the SH3BP2 gene have been identified in about 80 percent of people with cherubism. In most of the remaining cases, the genetic cause of the condition is unknown.  The SH3BP2 gene provides instructions for making a protein whose exact function is unclear.
    