Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to sitosterolemia ?
    ### Response:
    Sitosterolemia is caused by mutations in the ABCG5 or ABCG8 gene. These genes provide instructions for making the two halves of a protein called sterolin. This protein is involved in eliminating plant sterols, which cannot be used by human cells.  Sterolin is a transporter protein, which is a type of protein that moves substances across cell membranes.
    