Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Severe achondroplasia with developmental delay and acanthosis nigricans ?
    ### Response:
    What are the signs and symptoms of Severe achondroplasia with developmental delay and acanthosis nigricans? The Human Phenotype Ontology provides the following list of signs and symptoms for Severe achondroplasia with developmental delay and acanthosis nigricans.
    