Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spastic paraplegia type 4 ?
    ### Response:
    Mutations in the SPAST gene cause spastic paraplegia type 4. The SPAST gene provides instructions for producing a protein called spastin. Spastin is found throughout the body, particularly in certain nerve cells (neurons). The spastin protein plays a role in the function of microtubules, which are rigid, hollow fibers that make up the cell's structural framework (the cytoskeleton).
    