Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Peutz-Jeghers syndrome ?
    ### Response:
    What causes Peutz-Jeghers syndrome? Peutz-Jeghers syndrome (PJS) is caused by changes (mutations) in the STK11 gene. STK11 is a tumor suppressor gene which means that it encodes a protein that helps keep cells from growing and dividing too rapidly or in an uncontrolled way.
    