Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Costeff syndrome ?
    ### Response:
    Mutations in the OPA3 gene cause Costeff syndrome. The OPA3 gene provides instructions for making a protein whose exact function is unknown. The OPA3 protein is found in structures called mitochondria, which are the energy-producing centers of cells. Researchers speculate that the OPA3 protein is involved in regulating the shape of mitochondria.
    