Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to tuberous sclerosis complex ?
    ### Response:
    Mutations in the TSC1 or TSC2 gene can cause tuberous sclerosis complex. The TSC1 and TSC2 genes provide instructions for making the proteins hamartin and tuberin, respectively. Within cells, these two proteins likely work together to help regulate cell growth and size.
    