Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to limb-girdle muscular dystrophy ?
    ### Response:
    The various forms of limb-girdle muscular dystrophy are caused by mutations in many different genes. These genes provide instructions for making proteins that are involved in muscle maintenance and repair.  Some of the proteins produced from these genes assemble with other proteins into larger protein complexes.
    