Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of 48,XXYY syndrome ?
    ### Response:
    What are signs and symptoms of 48,XXYY syndrome? 48,XXYY affects various body systems including disruption of male sexual development. Adolescent and adult males with this condition typically have small testes that do not produce enough testosterone, which is the hormone that directs male sexual development.
    