Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial pityriasis rubra pilaris ?
    ### Response:
    In most cases of pityriasis rubra pilaris, the cause of the condition is unknown. However, mutations in the CARD14 gene have been found to cause the familial form of the disorder in a few affected families. The CARD14 gene provides instructions for making a protein that turns on (activates) a group of interacting proteins known as nuclear factor-kappa-B (NF-B).
    