Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to core binding factor acute myeloid leukemia ?
    ### Response:
    CBF-AML is associated with chromosomal rearrangements between chromosomes 8 and 21 and within chromosome 16. The rearrangements involve the RUNX1, RUNX1T1, CBFB, and MYH11 genes. Two of these genes, RUNX1 and CBFB, provide instructions for making the two pieces of a protein complex known as core binding factor (CBF).
    