Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to phosphoglycerate kinase deficiency ?
    ### Response:
    Phosphoglycerate kinase deficiency is caused by mutations in the PGK1 gene. This gene provides instructions for making an enzyme called phosphoglycerate kinase, which is involved in a critical energy-producing process in cells known as glycolysis. During glycolysis, the simple sugar glucose is broken down to produce energy.
    