Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) craniofacial-deafness-hand syndrome ?
    ### Response:
    Craniofacial-deafness-hand syndrome is characterized by distinctive facial features, profound hearing loss, and hand abnormalities.  The distinctive facial features of people with craniofacial-deafness-hand syndrome result from a variety of developmental abnormalities involving the skull (cranium) and face.
    