Below is an instruction from Human. Write a response.
    ### Instruction:
    Is Pyruvate dehydrogenase deficiency inherited ?
    ### Response:
    How is pyruvate dehydrogenase deficiency inherited? Pyruvate dehydrogenase deficiency is most commonly caused by mutations in the E1 alpha gene, which is located on the X chromosome (one of the sex chromosomes) and is typically inherited in an X-linked dominant manner.
    