Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to fragile X syndrome ?
    ### Response:
    Mutations in the FMR1 gene cause fragile X syndrome. The FMR1 gene provides instructions for making a protein called FMRP. This protein helps regulate the production of other proteins and plays a role in the development of synapses, which are specialized connections between nerve cells.
    