Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to factor XIII deficiency ?
    ### Response:
    Inherited factor XIII deficiency results from mutations in the F13A1 gene or, less commonly, the F13B gene. These genes provide instructions for making the two parts (subunits) of a protein called factor XIII. This protein plays a critical role in the coagulation cascade, which is a series of chemical reactions that forms blood clots in response to injury.
    