Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Li-Fraumeni syndrome ?
    ### Response:
    The CHEK2 and TP53 genes are associated with Li-Fraumeni syndrome.  More than half of all families with Li-Fraumeni syndrome have inherited mutations in the TP53 gene. TP53 is a tumor suppressor gene, which means that it normally helps control the growth and division of cells.
    