Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to PDGFRA-associated chronic eosinophilic leukemia ?
    ### Response:
    PDGFRA-associated chronic eosinophilic leukemia is caused by mutations in the PDGFRA gene. This condition usually occurs as a result of genetic rearrangements that fuse part of the PDGFRA gene with part of another gene. Rarely, changes in single DNA building blocks (point mutations) in the PDGFRA gene are found in people with this condition.
    