Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital contractural arachnodactyly ?
    ### Response:
    Mutations in the FBN2 gene cause congenital contractural arachnodactyly. The FBN2 gene provides instructions for producing the fibrillin-2 protein. Fibrillin-2 binds to other proteins and molecules to form threadlike filaments called microfibrils. Microfibrils become part of the fibers that provide strength and flexibility to connective tissue that supports the body's joints and organs.
    