Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Donnai-Barrow syndrome ?
    ### Response:
    Mutations in the LRP2 gene cause Donnai-Barrow syndrome. The LRP2 gene provides instructions for making a protein called megalin, which functions as a receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks.
    