Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital plasminogen deficiency ?
    ### Response:
    Congenital plasminogen deficiency is caused by mutations in the PLG gene. This gene provides instructions for making a protein called plasminogen. Enzymes called plasminogen activators convert plasminogen into the protein plasmin, which breaks down another protein called fibrin.
    