Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to activated PI3K-delta syndrome ?
    ### Response:
    Activated PI3K-delta syndrome is caused by mutations in the PIK3CD gene, which provides instructions for making a protein called p110 delta (p110). This protein is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K), which turns on signaling pathways within cells.
    