Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to isolated ectopia lentis ?
    ### Response:
    Mutations in the FBN1 or ADAMTSL4 gene cause isolated ectopia lentis. These genes provide instructions for making proteins that are necessary for the formation of threadlike filaments called microfibrils. Microfibrils provide support to many tissues, including the lenses of the eyes, which are held in position by these filaments.
    