Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to lamellar ichthyosis ?
    ### Response:
    Mutations in one of many genes can cause lamellar ichthyosis. These genes provide instructions for making proteins that are found in the outermost layer of the skin (the epidermis). The skin abnormalities associated with lamellar ichthyosis disrupt the normal formation of the epidermis, resulting in impaired regulation of body temperature, water retention, and resistance to infections.
    