Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple lentigines syndrome ?
    ### Response:
    Mutations in the PTPN11, RAF1, or BRAF genes cause multiple lentigines syndrome. Approximately 90 percent of individuals with multiple lentigines syndrome have mutations in the PTPN11 gene. RAF1 and BRAF gene mutations are responsible for a total of about 10 percent of cases.
    