Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to atypical hemolytic-uremic syndrome ?
    ### Response:
    Atypical hemolytic-uremic syndrome often results from a combination of environmental and genetic factors. Mutations in at least seven genes appear to increase the risk of developing the disorder. Mutations in a gene called CFH are most common; they have been found in about 30 percent of all cases of atypical hemolytic-uremic syndrome.
    