Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Bannayan-Riley-Ruvalcaba syndrome ?
    ### Response:
    About 60 percent of all cases of Bannayan-Riley-Ruvalcaba syndrome result from mutations in the PTEN gene. Another 10 percent of cases are caused by a large deletion of genetic material that includes part or all of this gene. The protein produced from the PTEN gene is a tumor suppressor, which means that it normally prevents cells from growing and dividing (proliferating) too rapidly or in an uncontrolled way.
    