Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spastic paraplegia type 31 ?
    ### Response:
    Spastic paraplegia type 31 is caused by mutations in the REEP1 gene. This gene provides instructions for making a protein called receptor expression-enhancing protein 1 (REEP1), which is found in neurons in the brain and spinal cord. The REEP1 protein is located within cell compartments called mitochondria, which are the energy-producing centers in cells, and the endoplasmic reticulum, which helps with protein processing and transport.
    