Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to progressive supranuclear palsy ?
    ### Response:
    In most cases, the genetic cause of progressive supranuclear palsy is unknown. Rarely, the disease results from mutations in the MAPT gene. Certain normal variations (polymorphisms) in the MAPT gene have also been associated with an increased risk of developing progressive supranuclear palsy.
    