Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Coffin-Siris syndrome ?
    ### Response:
    Coffin-Siris syndrome is caused by mutations in the ARID1A, ARID1B, SMARCA4, SMARCB1, or SMARCE1 gene. Each of these genes provides instructions for making one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling.
    