Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to amelogenesis imperfecta ?
    ### Response:
    Mutations in the AMELX, ENAM, MMP20, and FAM83H genes can cause amelogenesis imperfecta. The AMELX, ENAM, and MMP20 genes provide instructions for making proteins that are essential for normal tooth development. Most of these proteins are involved in the formation of enamel, which is the hard, calcium-rich material that forms the protective outer layer of each tooth.
    