Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mucolipidosis type IV ?
    ### Response:
    Mutations in the MCOLN1 gene cause mucolipidosis type IV. This gene provides instructions for making a protein called mucolipin-1. This protein is located in the membranes of lysosomes and endosomes, compartments within the cell that digest and recycle materials.
    