Below is an instruction from Human. Write a response.
    ### Instruction:
    What is the outlook for Generalized Gangliosidoses ?
    ### Response:
    Children with early infantile GM1 often die by age 3 from cardiac complications or pneumonia. Children with the early-onset form of Tay-Sachs disease may eventually need a feeding tube and often die by age 4 from recurring infection. Children with Sandhoff disease generally die by age 3 from respiratory infections.
    