Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to PPM-X syndrome ?
    ### Response:
    Mutations in the MECP2 gene cause PPM-X syndrome. The MECP2 gene provides instructions for making a protein called MeCP2 that is critical for normal brain function. Researchers believe that this protein has several functions, including regulating other genes in the brain by switching them off when they are not needed.
    