Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Irritable Bowel Syndrome in Children ?
    ### Response:
    The causes of IBS are not well understood. Researchers believe a combination of physical and mental health problems can lead to IBS. The possible causes of IBS in children include the following:
                
- Brain-gut signal problems. Signals between the brain and nerves of the small and large intestines, also called the gut, control how the intestines work.
    