Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Pendred syndrome ?
    ### Response:
    Mutations in the SLC26A4 gene cause about half of all cases of Pendred syndrome. The SLC26A4 gene provides instructions for making a protein called pendrin. This protein transports negatively charged particles (ions), including chloride, iodide, and bicarbonate, into and out of cells.
    