Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to guanidinoacetate methyltransferase deficiency ?
    ### Response:
    Mutations in the GAMT gene cause guanidinoacetate methyltransferase deficiency. The GAMT gene provides instructions for making the enzyme guanidinoacetate methyltransferase. This enzyme participates in the two-step production (synthesis) of the compound creatine from the protein building blocks (amino acids) glycine, arginine, and methionine.
    