Below is an instruction from Human. Write a response.
    ### Instruction:
    How to diagnose Coffin-Siris syndrome ?
    ### Response:
    How is Coffin-Siris syndrome diagnosed? Diagnosis of Coffin-Siris syndrome is largely based upon the presence or absence of common signs and symptoms in the individual. While formal diagnostic criteria have not been established, most individuals with a clinical diagnosis of Coffin-Siris syndrome have certain features in common.
    