Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Leukoencephalopathy with vanishing white matter ?
    ### Response:
    What causes leukoencephalopathy with vanishing white matter? Leukoencephalopathy with vanishing white matter is a genetic condition caused by mutations in any of 5 genes - EIF2B1, EIF2B2, EIF2B3, EIF2B4, and EIF2B5. These genes give the body instructions to make the five parts (subunits) of a protein called eIF2B.
    