Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to ZAP70-related severe combined immunodeficiency ?
    ### Response:
    As the name indicates, this condition is caused by mutations in the ZAP70 gene. The ZAP70 gene provides instructions for making a protein called zeta-chain-associated protein kinase. This protein is part of a signaling pathway that directs the development of and turns on (activates) immune system cells called T cells.
    