Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Alport syndrome ?
    ### Response:
    What causes Alport syndrome? Alport syndrome may be caused by mutations in either the COL4A3, COL4A4, or COL4A5 genes. These genes each provide instructions for making one component of a protein called type IV collagen, which plays an important role in the glomeruli of the kidneys.
    