Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Zellweger spectrum disorder ?
    ### Response:
    Mutations in at least 12 genes have been found to cause Zellweger spectrum disorder. These genes provide instructions for making a group of proteins known as peroxins, which are essential for the formation and normal functioning of cell structures called peroxisomes.
    