Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Muckle-Wells syndrome ?
    ### Response:
    Muckle-Wells syndrome is a disorder characterized by periodic episodes of skin rash, fever, and joint pain. Progressive hearing loss and kidney damage also occur in this disorder.  People with Muckle-Wells syndrome have recurrent "flare-ups" that begin during infancy or early childhood.
    