Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Konigsmark Knox Hussels syndrome ?
    ### Response:
    What causes Konigsmark Knox Hussels syndrome? Konigsmark Knox Hussels syndrome is caused by a particular mutation in the OPA1 gene. In most cases, this condition is caused by a mutation that replaces the amino acid arginine with the amino acid histidine at position 445 in the OPA1 protein.
    