Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to acral peeling skin syndrome ?
    ### Response:
    Acral peeling skin syndrome is caused by mutations in the TGM5 gene. This gene provides instructions for making an enzyme called transglutaminase 5, which is a component of the outer layer of skin (the epidermis). Transglutaminase 5 plays a critical role in the formation of a structure called the cornified cell envelope, which surrounds epidermal cells and helps the skin form a protective barrier between the body and its environment.
    