Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 5q minus syndrome ?
    ### Response:
    5q- syndrome is caused by deletion of a region of DNA from the long (q) arm of chromosome 5. Most people with 5q- syndrome are missing a sequence of about 1.5 million DNA building blocks (base pairs), also written as 1.5 megabases (Mb). However, the size of the deleted region varies.
    