Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Langer-Giedion syndrome ?
    ### Response:
    Langer-Giedion syndrome is caused by the deletion or mutation of at least two genes on chromosome 8. Researchers have determined that the loss of a functional EXT1 gene is responsible for the multiple osteochondromas seen in people with Langer-Giedion syndrome.
    