Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mandibulofacial dysostosis with microcephaly ?
    ### Response:
    MFDM is caused by mutations in the EFTUD2 gene. This gene provides instructions for making one part (subunit) of two complexes called the major and minor spliceosomes. Spliceosomes help process messenger RNA (mRNA), which is a chemical cousin of DNA that serves as a genetic blueprint for making proteins.
    