Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Marfan syndrome ?
    ### Response:
    Mutations in the FBN1 gene cause Marfan syndrome. The FBN1 gene provides instructions for making a protein called fibrillin-1. Fibrillin-1 attaches (binds) to other fibrillin-1 proteins and other molecules to form threadlike filaments called microfibrils. Microfibrils become part of the fibers that provide strength and flexibility to connective tissue.
    