Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to complete LCAT deficiency ?
    ### Response:
    Complete LCAT deficiency is caused by mutations in the LCAT gene. This gene provides instructions for making an enzyme called lecithin-cholesterol acyltransferase (LCAT).  The LCAT enzyme plays a role in removing cholesterol from the blood and tissues by helping it attach to molecules called lipoproteins, which carry it to the liver.
    