Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial porencephaly ?
    ### Response:
    Mutations in the COL4A1 gene cause familial porencephaly. The COL4A1 gene provides instructions for making one component of a protein called type IV collagen. Type IV collagen molecules attach to each other to form complex protein networks. These protein networks are the main components of basement membranes, which are thin sheet-like structures that separate and support cells in many tissues.
    