Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple familial trichoepithelioma ?
    ### Response:
    Multiple familial trichoepithelioma can be caused by mutations in the CYLD gene. This gene provides instructions for making a protein that helps regulate nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins that help protect cells from self-destruction (apoptosis) in response to certain signals.
    