Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital hepatic fibrosis ?
    ### Response:
    Syndromes of which congenital hepatic fibrosis is a feature may be caused by changes in many different genes. The gene changes that cause isolated congenital hepatic fibrosis are unknown.  Congenital hepatic fibrosis is caused by problems in the development of the portal veins and bile ducts.
    