Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital generalized lipodystrophy ?
    ### Response:
    Mutations in the AGPAT2, BSCL2, CAV1, and PTRF genes cause congenital generalized lipodystrophy types 1 through 4, respectively. The proteins produced from these genes play important roles in the development and function of adipocytes, which are the fat-storing cells in adipose tissue.
    