Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mandibuloacral dysplasia ?
    ### Response:
    The two forms of mandibuloacral dysplasia are caused by mutations in different genes. Mutations in the LMNA gene cause MADA, and mutations in the ZMPSTE24 gene cause MADB. Within cells, these genes are involved in maintaining the structure of the nucleus and may play a role in many cellular processes.
    