Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to distal arthrogryposis type 1 ?
    ### Response:
    Distal arthrogryposis type 1 can be caused by mutations in at least two genes: TPM2 and MYBPC1. These genes are active (expressed) in muscle cells, where they interact with other muscle proteins to help regulate the tensing of muscle fibers (muscle contraction).
    