Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) progressive familial intrahepatic cholestasis ?
    ### Response:
    Progressive familial intrahepatic cholestasis (PFIC) is a disorder that causes progressive liver disease, which typically leads to liver failure. In people with PFIC, liver cells are less able to secrete a digestive fluid called bile. The buildup of bile in liver cells causes liver disease in affected individuals.
    