Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to type 1 diabetes ?
    ### Response:
    The causes of type 1 diabetes are unknown, although several risk factors have been identified. The risk of developing type 1 diabetes is increased by certain variants of the HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system.
    