Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Klinefelter syndrome ?
    ### Response:
    Klinefelter syndrome is a condition related to the X and Y chromosomes (the sex chromosomes). People typically have two sex chromosomes in each cell: females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). Most often, Klinefelter syndrome results from the presence of one extra copy of the X chromosome in each cell (47,XXY).
    