Below is an instruction from Human. Write a response.
    ### Instruction:
    How to diagnose Schimke immunoosseous dysplasia ?
    ### Response:
    How is Schimke immunoosseous dysplasia diagnosed? The diagnosis of SIOD is made on clinical findings.  The most definitive diagnostic findings are skeletal dysplasia (spondyloepiphyseal dysplasia), renal dysfunction (urinary protein loss), T lymphocyte deficiency, characteristic facial features, and hyperpigmented macules.
    