Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Paget's Disease of Bone ?
    ### Response:
    Symptoms Many people don't know they have Paget's disease because they have a mild case of the disease and do not have any symptoms. However, people with more advanced cases of the disease will likely have symptoms. Symptoms vary depending on which bone or bones are affected.
    