Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Smith-Magenis syndrome ?
    ### Response:
    Most people with Smith-Magenis syndrome have a deletion of genetic material from a specific region of chromosome 17. Although this region contains multiple genes, researchers believe that the loss of one particular gene, RAI1, in each cell is responsible for most of the characteristic features of this condition.
    