Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to polycystic kidney disease ?
    ### Response:
    Mutations in the PKD1, PKD2, and PKHD1 genes cause polycystic kidney disease.  Mutations in either the PKD1 or PKD2 gene can cause autosomal dominant polycystic kidney disease; PKD1 gene mutations cause ADPKD type 1, and PKD2 gene mutations cause ADPKD type 2.
    