Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Lesch-Nyhan syndrome ?
    ### Response:
    Mutations in the HPRT1 gene cause Lesch-Nyhan syndrome. The HPRT1 gene provides instructions for making an enzyme called hypoxanthine phosphoribosyltransferase 1. This enzyme is responsible for recycling purines, a type of building block of DNA and its chemical cousin RNA.
    