Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Norum disease ?
    ### Response:
    What are the signs and symptoms of Norum disease? Norum disease is marked by low plasma HDL levels and corneal clouding due to accumulation of cholesterol deposits in the cornea ('fish-eye'). Corneal opacity is often present at birth, beginning at the periphery of the cornea and progressing gradually to the center.
    