Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 9q22.3 microdeletion ?
    ### Response:
    People with a 9q22.3 microdeletion are missing a sequence of at least 352,000 DNA building blocks (base pairs), also written as 352 kilobases (kb), in the q22.3 region of chromosome 9. This 352-kb segment is known as the minimum critical region because it is the smallest deletion that has been found to cause the signs and symptoms described above.
    