Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Biotinidase deficiency ?
    ### Response:
    What are the signs and symptoms of Biotinidase deficiency? The signs and symptoms of biotinidase deficiency typically appear within the first few months of life, but the age of onset varies. Children with profound biotinidase deficiency, the more severe form of the condition, may have seizures, weak muscle tone (hypotonia), breathing problems, and delayed development.
    