Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Wilson disease ?
    ### Response:
    Wilson disease is caused by mutations in the ATP7B gene. This gene provides instructions for making a protein called copper-transporting ATPase 2, which plays a role in the transport of copper from the liver to other parts of the body. Copper is necessary for many cellular functions, but it is toxic when present in excessive amounts.
    