Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to central core disease ?
    ### Response:
    Mutations in the RYR1 gene cause central core disease.  The RYR1 gene provides instructions for making a protein called ryanodine receptor 1. This protein plays an essential role in skeletal muscles. For the body to move normally, these muscles must tense (contract) and relax in a coordinated way.
    