Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to aminoacylase 1 deficiency ?
    ### Response:
    Aminoacylase 1 deficiency is caused by mutations in the ACY1 gene. This gene provides instructions for making an enzyme called aminoacylase 1, which is involved in the breakdown of proteins when they are no longer needed. Many proteins in the body have an acetyl group attached to one end.
    