Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Pyruvate dehydrogenase deficiency ?
    ### Response:
    What are the signs and symptoms of Pyruvate dehydrogenase deficiency? Pyruvate dehydrogenase (PDH) deficiency can have a significant effect on fetal development, which may become apparent during late pregnancy with poor fetal weight gain and decreasing levels of estriol in the urine of the mother during pregnancy.
    