Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to CHMP2B-related frontotemporal dementia ?
    ### Response:
    CHMP2B-related frontotemporal dementia results from mutations in the CHMP2B gene. This gene provides instructions for making a protein called charged multivesicular body protein 2B. This protein is active in the brain, where it plays an essential role in transporting proteins that need to be broken down (degraded).
    