Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) autosomal dominant hyper-IgE syndrome ?
    ### Response:
    Autosomal dominant hyper-IgE syndrome (AD-HIES), also known as Job syndrome, is a condition that affects several body systems, particularly the immune system. Recurrent infections are common in people with this condition. Affected individuals tend to have frequent bouts of pneumonia, which are caused by certain kinds of bacteria that infect the lungs and cause inflammation.
    