Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Chanarin-Dorfman syndrome ?
    ### Response:
    Mutations in the ABHD5 gene cause Chanarin-Dorfman syndrome. The ABHD5 gene provides instructions for making a protein that turns on (activates) the ATGL enzyme, which breaks down triglycerides. Triglycerides are the main source of stored energy in cells. These fats must be broken down into simpler molecules called fatty acids before they can be used for energy.
    