Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spastic paraplegia type 15 ?
    ### Response:
    Mutations in the ZFYVE26 gene cause spastic paraplegia type 15. This gene provides instructions for making a protein called spastizin. This protein is important in a process called autophagy, in which worn-out cell parts and unneeded proteins are recycled within cells.
    