Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to progressive pseudorheumatoid dysplasia ?
    ### Response:
    PPRD is caused by mutations in the WISP3 gene. The function of the protein produced from this gene is not well understood, although it is thought to play a role in bone growth and cartilage maintenance. The WISP3 protein is made in cells called chondrocytes, which produce and maintain cartilage.
    