Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Microcephalic osteodysplastic primordial dwarfism type 1 ?
    ### Response:
    What are the signs and symptoms of Microcephalic osteodysplastic primordial dwarfism type 1? Individuals with MOPD1 may have low birth weight, growth retardation, short limbs, broad hands, small head size (microcephaly), abnormal bone growth (skeletal dysplasia) and a distinct facial appearance.
    