Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to metachromatic leukodystrophy ?
    ### Response:
    Most individuals with metachromatic leukodystrophy have mutations in the ARSA gene, which provides instructions for making the enzyme arylsulfatase A. This enzyme is located in cellular structures called lysosomes, which are the cell's recycling centers. Within lysosomes, arylsulfatase A helps break down sulfatides.
    