Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Mandibulofacial dysostosis with microcephaly ?
    ### Response:
    What causes mandibulofacial dysostosis with microcephaly? Mandibulofacial dysostosis with microcephaly (MFDM) is caused by mutations in the EFTUD2 gene. This gene gives the body instructions for making part of spliceosomes, which help process a type of RNA- a chemical cousin of DNA that serves as a genetic blueprint for making proteins.
    