Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the complications of Primary Biliary Cirrhosis ?
    ### Response:
    Most complications of primary biliary cirrhosis are related to cirrhosis and start after primary biliary cirrhosis progresses to cirrhosis. In some cases, portal hypertension and esophageal varices may develop before cirrhosis.
                
Portal hypertension.
    