Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 3-methylglutaconyl-CoA hydratase deficiency ?
    ### Response:
    Mutations in the AUH gene cause 3-methylglutaconyl-CoA hydratase deficiency. This gene provides instructions for producing 3-methylglutaconyl-CoA hydratase, an enzyme that is involved in breaking down a protein building block (amino acid) called leucine to provide energy for cells.
    