Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mucopolysaccharidosis type I ?
    ### Response:
    Mutations in the IDUA gene cause MPS I. The IDUA gene provides instructions for producing an enzyme that is involved in the breakdown of large sugar molecules called glycosaminoglycans (GAGs). GAGs were originally called mucopolysaccharides, which is where this condition gets its name.
    