Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Kyrle disease ?
    ### Response:
    Kyrle disease is a skin disease characterized by the formation of large papules and is often associated with underlying hepatic, renal or diabetic disorders. It can affect both men and women throughout life, although the average age of onset is 30 years. Lesions typically begin as small papules with silvery scales that eventually grow and form red-brown nodules with a central keratin (horny) plug.
    