Below is an instruction from Human. Write a response.
    ### Instruction:
    Is hypercholesterolemia inherited ?
    ### Response:
    Most cases of high cholesterol are not caused by a single inherited condition, but result from a combination of lifestyle choices and the effects of variations in many genes.  Inherited forms of hypercholesterolemia resulting from mutations in the LDLR, APOB, or PCSK9 gene have an autosomal dominant pattern of inheritance.
    