Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to fragile X-associated primary ovarian insufficiency ?
    ### Response:
    Mutations in the FMR1 gene increase a woman's risk of developing FXPOI. The FMR1 gene provides instructions for making a protein called FMRP, which helps regulate the production of other proteins. This protein plays a role in the functioning of nerve cells.
    