Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to primary ciliary dyskinesia ?
    ### Response:
    Primary ciliary dyskinesia can result from mutations in many different genes. These genes provide instructions for making proteins that form the inner structure of cilia and produce the force needed for cilia to bend. Coordinated back and forth movement of cilia is necessary for the normal functioning of many organs and tissues.
    