Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to beta-mannosidosis ?
    ### Response:
    Mutations in the MANBA gene cause beta-mannosidosis.  The MANBA gene provides instructions for making the enzyme beta-mannosidase. This enzyme works in the lysosomes, which are compartments that digest and recycle materials in the cell. Within lysosomes, the enzyme helps break down complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins).
    