Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) autosomal recessive hyper-IgE syndrome ?
    ### Response:
    Autosomal recessive hyper-IgE syndrome (AR-HIES) is a disorder of the immune system. A hallmark feature of the condition is recurrent infections that are severe and can be life-threatening. Skin infections can be caused by bacteria, viruses, or fungi. These infections cause rashes, blisters, accumulations of pus (abscesses), open sores, and scaling.
    