Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Chediak-Higashi syndrome ?
    ### Response:
    Chediak-Higashi syndrome is caused by mutations in the LYST gene. This gene provides instructions for making a protein known as the lysosomal trafficking regulator. Researchers believe that this protein plays a role in the transport (trafficking) of materials into structures called lysosomes and similar cell structures.
    