Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to GM1 gangliosidosis ?
    ### Response:
    Mutations in the GLB1 gene cause GM1 gangliosidosis. The GLB1 gene provides instructions for making an enzyme called beta-galactosidase (-galactosidase), which plays a critical role in the brain. This enzyme is located in lysosomes, which are compartments within cells that break down and recycle different types of molecules.
    