Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to severe congenital neutropenia ?
    ### Response:
    Severe congenital neutropenia can result from mutations in at least five different genes. These genes play a role in the maturation and function of neutrophils, which are cells produced by the bone marrow. Neutrophils secrete immune molecules and ingest and break down foreign invaders.
    