Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cytochrome c oxidase deficiency ?
    ### Response:
    Cytochrome c oxidase deficiency is caused by mutations in one of at least 14 genes. In humans, most genes are found in DNA in the cell's nucleus (nuclear DNA). However, some genes are found in DNA in specialized structures in the cell called mitochondria. This type of DNA is known as mitochondrial DNA (mtDNA).
    