Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to isovaleric acidemia ?
    ### Response:
    Mutations in the IVD gene cause isovaleric acidemia.  The IVD gene provides instructions for making an enzyme that plays an essential role in breaking down proteins from the diet. Specifically, this enzyme helps process the amino acid leucine, which is part of many proteins.
    