Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Shapiro syndrome ?
    ### Response:
    What are the signs and symptoms of Shapiro syndrome? Shapiro syndrome generally consists of three findings: spontaneous periodic hypothermia, excessive sweating, and agenesis of the corpus callosum. However, there has been a documented case of a 4-year-old girl with Shapiro syndrome who did not have agenesis of the corpus callosum.
    