Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Pompe disease ?
    ### Response:
    Mutations in the GAA gene cause Pompe disease. The GAA gene provides instructions for producing an enzyme called acid alpha-glucosidase (also known as acid maltase). This enzyme is active in lysosomes, which are structures that serve as recycling centers within cells.
    