Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hepatic lipase deficiency ?
    ### Response:
    Hepatic lipase deficiency is caused by mutations in the LIPC gene. This gene provides instructions for making an enzyme called hepatic lipase. This enzyme is produced by liver cells and released into the bloodstream where it helps convert very low-density lipoproteins (VLDLs) and intermediate-density lipoproteins (IDLs) to LDLs.
    