Below is an instruction from Human. Write a response.
    ### Instruction:
    Is Klinefelter syndrome inherited ?
    ### Response:
    Klinefelter syndrome and its variants are not inherited; these chromosomal changes usually occur as random events during the formation of reproductive cells (eggs and sperm) in a parent. An error in cell division called nondisjunction results in a reproductive cell with an abnormal number of chromosomes.
    