Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to keratoderma with woolly hair ?
    ### Response:
    Mutations in the JUP, DSP, DSC2, and KANK2 genes cause keratoderma with woolly hair types I through IV, respectively. The JUP, DSP, and DSC2 genes provide instructions for making components of specialized cell structures called desmosomes. Desmosomes are located in the membrane surrounding certain cells, including skin and heart muscle cells.
    