Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pulmonary veno-occlusive disease ?
    ### Response:
    The primary genetic cause of PVOD is mutations in the EIF2AK4 gene. Mutations in other genes may cause a small percentage of cases. Other suspected causes of PVOD include viral infection and exposure to toxic chemicals, including certain chemotherapy drugs.
    