Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cholesteryl ester storage disease ?
    ### Response:
    Mutations in the LIPA gene cause cholesteryl ester storage disease.  The LIPA gene provides instructions for making an enzyme called lysosomal acid lipase. This enzyme is found in the lysosomes (compartments that digest and recycle materials in the cell), where it breaks down lipids such as cholesteryl esters and triglycerides.
    