Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple mitochondrial dysfunctions syndrome ?
    ### Response:
    Multiple mitochondrial dysfunctions syndrome can be caused by mutations in the NFU1 or BOLA3 gene. The proteins produced from each of these genes appear to be involved in the formation of molecules called iron-sulfur (Fe-S) clusters or in the attachment of these clusters to other proteins.
    