Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to uromodulin-associated kidney disease ?
    ### Response:
    Mutations in the UMOD gene cause uromodulin-associated kidney disease. This gene provides instructions for making the uromodulin protein, which is produced by the kidneys and then excreted from the body in urine. The function of uromodulin remains unclear, although it is known to be the most abundant protein in the urine of healthy individuals.
    