Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Opitz G/BBB syndrome ?
    ### Response:
    X-linked Opitz G/BBB syndrome is caused by mutations in the MID1 gene. The MID1 gene provides instructions for making a protein called midline-1. This protein attaches (binds) to microtubules, which are rigid, hollow fibers that make up the cell's structural framework (the cytoskeleton).
    