Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to retinal arterial macroaneurysm with supravalvular pulmonic stenosis ?
    ### Response:
    RAMSVPS is caused by a mutation in the IGFBP7 gene. This gene provides instructions for making a protein called insulin-like growth factor-binding protein 7 (IGFBP7). The IGFBP7 protein is active in the lining of blood vessels (the vascular endothelium). It is thought to help stop a pathway called BRAF signaling, which is involved in directing cell growth.
    