Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to rippling muscle disease ?
    ### Response:
    Rippling muscle disease can be caused by mutations in the CAV3 gene. Muscle conditions caused by CAV3 gene mutations are called caveolinopathies. The CAV3 gene provides instructions for making a protein called caveolin-3, which is found in the membrane surrounding muscle cells.
    