Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 22q13.3 deletion syndrome ?
    ### Response:
    22q13.3 deletion syndrome is caused by a deletion near the end of the long (q) arm of chromosome 22. The signs and symptoms of 22q13.3 deletion syndrome are probably related to the loss of multiple genes in this region. The size of the deletion varies among affected individuals.
    