Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to monilethrix ?
    ### Response:
    Monilethrix is caused by mutations in one of several genes. Mutations in the KRT81 gene, the KRT83 gene, the KRT86 gene, or the DSG4 gene account for most cases of monilethrix. These genes provide instructions for making proteins that give structure and strength to strands of hair.
    