Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Multicentric reticulohistiocytosis ?
    ### Response:
    What are the signs and symptoms of Multicentric reticulohistiocytosis? The main symptoms of multicentric reticulohistiocytosis are arthritis and red to purple skin nodules varying in size from 1 to 10 mm. The nodules can be found on any part of the body but tend to concentrate on the face and hands and decrease in number from head to toe.
    