Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Alport syndrome ?
    ### Response:
    Mutations in the COL4A3, COL4A4, and COL4A5 genes cause Alport syndrome. These genes each provide instructions for making one component of a protein called type IV collagen. This protein plays an important role in the kidneys, specifically in structures called glomeruli.
    