Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to chronic granulomatous disease ?
    ### Response:
    Mutations in the CYBA, CYBB, NCF1, NCF2, or NCF4 gene can cause chronic granulomatous disease. There are five types of this condition that are distinguished by the gene that is involved. The proteins produced from the affected genes are parts (subunits) of an enzyme complex called NADPH oxidase, which plays an essential role in the immune system.
    