Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Pontocerebellar hypoplasia type 1 ?
    ### Response:
    What are the signs and symptoms of Pontocerebellar hypoplasia type 1? Pontocerebellar hypoplasia type 1 (PCH1) may first present in the prenatal period with reduced fetal movement. Polyhydramnios may also be noted. In most cases, the condition is obvious in the newborn period when respiratory insufficiency and muscle weakness present.
    