Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to lymphedema-distichiasis syndrome ?
    ### Response:
    Lymphedema-distichiasis syndrome is caused by mutations in the FOXC2 gene. The FOXC2 gene provides instructions for making a protein that plays a critical role in the formation of many organs and tissues before birth. The FOXC2 protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of many other genes.
    