Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Muckle-Wells syndrome ?
    ### Response:
    Mutations in the NLRP3 gene (also known as CIAS1) cause Muckle-Wells syndrome. The NLRP3 gene provides instructions for making a protein called cryopyrin.  Cryopyrin belongs to a family of proteins called nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins.
    