Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to renal coloboma syndrome ?
    ### Response:
    Renal coloboma syndrome is caused by mutations in the PAX2 gene. The PAX2 gene provides instructions for making a protein that is involved in the early development of the eyes, ears, brain and spinal cord (central nervous system), kidneys, and genital tract.
    