Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to SADDAN ?
    ### Response:
    Mutations in the FGFR3 gene cause SADDAN. The FGFR3 gene provides instructions for making a protein that is involved in the development and maintenance of bone and brain tissue. A mutation in this gene may cause the FGFR3 protein to be overly active, which leads to the disturbances in bone growth that are characteristic of this disorder.
    