Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mal de Meleda ?
    ### Response:
    Mal de Meleda is caused by mutations in the SLURP1 gene. This gene provides instructions for making a protein that interacts with other proteins, called receptors, and is likely involved in signaling within cells. Studies show that the SLURP-1 protein can attach (bind) to nicotinic acetylcholine receptors (nAChRs) in the skin.
    