Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Erdheim-Chester disease ?
    ### Response:
    More than half of people with Erdheim-Chester disease have a specific mutation in the BRAF gene. Mutations in other genes are also thought to be involved in this disorder.  The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus.
    