Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to gastrointestinal stromal tumor ?
    ### Response:
    Genetic changes in one of several genes are involved in the formation of GISTs. About 80 percent of cases are associated with a mutation in the KIT gene, and about 10 percent of cases are associated with a mutation in the PDGFRA gene. Mutations in the KIT and PDGFRA genes are associated with both familial and sporadic GISTs.
    