Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multiple endocrine neoplasia ?
    ### Response:
    Mutations in the MEN1, RET, and CDKN1B genes can cause multiple endocrine neoplasia.  Mutations in the MEN1 gene cause multiple endocrine neoplasia type 1. This gene provides instructions for producing a protein called menin. Menin acts as a tumor suppressor, which means it normally keeps cells from growing and dividing too rapidly or in an uncontrolled way.
    