Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to early-onset glaucoma ?
    ### Response:
    Approximately 10 percent to 33 percent of people with juvenile open-angle glaucoma have mutations in the MYOC gene. MYOC gene mutations have also been detected in some people with primary congenital glaucoma. The MYOC gene provides instructions for producing a protein called myocilin.
    