Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Dubin-Johnson syndrome ?
    ### Response:
    Dubin-Johnson syndrome is caused by mutations in the ABCC2 gene. The ABCC2 gene provides instructions for making a protein called multidrug resistance protein 2 (MRP2). This protein acts as a pump to transport substances out of the liver, kidneys, intestine, or placenta so they can be excreted from the body.
    