Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to prothrombin thrombophilia ?
    ### Response:
    Prothrombin thrombophilia is caused by a particular mutation in the F2 gene. The F2 gene plays a critical role in the formation of blood clots in response to injury. The protein produced from the F2 gene, prothrombin (also called coagulation factor II), is the precursor to a protein called thrombin that initiates a series of chemical reactions in order to form a blood clot.
    