Below is an instruction from Human. Write a response.
    ### Instruction:
    Is Holt-Oram syndrome inherited ?
    ### Response:
    How is Holt-Oram syndrome inherited? Holt-Oram syndrome (HOS) is inherited in an autosomal dominant manner. This means that having only one changed (mutated) copy of the responsible gene in each cell is enough to cause signs and symptoms of the condition. In most cases, the mutation in the gene occurs for the first time in the affected person and is not inherited from a parent.
    