Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to gyrate atrophy of the choroid and retina ?
    ### Response:
    Mutations in the OAT gene cause gyrate atrophy. The OAT gene provides instructions for making the enzyme ornithine aminotransferase. This enzyme is active in the energy-producing centers of cells (mitochondria), where it helps break down a molecule called ornithine.
    