Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to corticosteroid-binding globulin deficiency ?
    ### Response:
    Mutations in the SERPINA6 gene cause corticosteroid-binding globulin deficiency. The SERPINA6 gene provides instructions for making a protein called corticosteroid-binding globulin (CBG), which is primarily produced in the liver. The CBG protein attaches (binds) to a hormone called cortisol.
    