Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to adolescent idiopathic scoliosis ?
    ### Response:
    The term "idiopathic" means that the cause of this condition is unknown. Adolescent idiopathic scoliosis probably results from a combination of genetic and environmental factors. Studies suggest that the abnormal spinal curvature may be related to hormonal problems, abnormal bone or muscle growth, nervous system abnormalities, or other factors that have not been identified.
    