Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to glutamate formiminotransferase deficiency ?
    ### Response:
    Mutations in the FTCD gene cause glutamate formiminotransferase deficiency. The FTCD gene provides instructions for making the enzyme formiminotransferase cyclodeaminase. This enzyme is involved in the last two steps in the breakdown (metabolism) of the amino acid histidine, a building block of most proteins.
    