Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Tangier disease ?
    ### Response:
    Tangier disease is an inherited disorder characterized by significantly reduced levels of high-density lipoprotein (HDL) in the blood. HDL transports cholesterol and certain fats called phospholipids from the body's tissues to the liver, where they are removed from the blood.
    