Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Hereditary endotheliopathy, retinopathy, nephropathy, and stroke ?
    ### Response:
    What are the signs and symptoms of Hereditary endotheliopathy, retinopathy, nephropathy, and stroke? Very few cases of hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS) have been reported. Based upon these reports, it appears that symptoms often begin in the 30s or 40s.
    