Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to McKusick-Kaufman syndrome ?
    ### Response:
    Mutations in the MKKS gene cause McKusick-Kaufman syndrome. This gene provides instructions for making a protein that plays an important role in the formation of the limbs, heart, and reproductive system. The protein's structure suggests that it may act as a chaperonin, which is a type of protein that helps fold other proteins.
    