Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Hypomyelination with atrophy of basal ganglia and cerebellum ?
    ### Response:
    What causes hypomyelination with atrophy of basal ganglia and cerebellum (H-ABC)? Hypomyelination with atrophy of basal ganglia and cerebellum (H-ABC) is caused by a mutation in the TUBB4A gene. The mutation usually occurs for the first time in a family as a result of a new mutation in the affected individual.
    