Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Barth Syndrome ?
    ### Response:
    Barth syndrome (BTHS) is a rare, genetic disorder of lipid metabolism that primarily affects males. It is caused by a mutation in the tafazzin gene (TAZ, also called G4.5) which leads to decreased production of an enzyme required to produce cardiolipin. Cardiolipin is an essential lipid that is important in energy metabolism.
    