Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital hyperinsulinism ?
    ### Response:
    Congenital hyperinsulinism is caused by mutations in genes that regulate the release (secretion) of insulin, which is produced by beta cells in the pancreas. Insulin clears excess sugar (in the form of glucose) from the bloodstream by passing glucose into cells to be used as energy.
    