Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Dowling-Degos disease ?
    ### Response:
    Mutations in the KRT5 gene cause Dowling-Degos disease. The KRT5 gene provides instructions for making a protein called keratin 5. Keratins are a family of proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails.
    