Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Cole disease ?
    ### Response:
    Cole disease is caused by mutations in the ENPP1 gene. This gene provides instructions for making a protein that helps to prevent minerals, including calcium, from being deposited in body tissues where they do not belong. It also plays a role in controlling cell signaling in response to the hormone insulin, through interaction between a part of the ENPP1 protein called the SMB2 domain and the insulin receptor.
    