Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to juvenile primary osteoporosis ?
    ### Response:
    Mutations in the LRP5 gene can cause juvenile primary osteoporosis. This gene provides instructions for making a protein that participates in a chemical signaling pathway that affects the way cells and tissues develop. In particular, the LRP5 protein is involved in the regulation of bone mineral density.
    