Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Townes-Brocks syndrome ?
    ### Response:
    What are the signs and symptoms of Townes-Brocks syndrome? Townes-Brocks syndrome is characterized by an obstruction of the anal opening (imperforate anus), abnormally shaped ears, and hand malformations that most often affect the thumbs. Most people with this condition have at least two of these three major features.
    