Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to popliteal pterygium syndrome ?
    ### Response:
    Mutations in the IRF6 gene cause popliteal pterygium syndrome. The IRF6 gene provides instructions for making a protein that plays an important role in early development. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.
    