Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Kawasaki disease ?
    ### Response:
    The causes of Kawasaki disease are not well understood. The disorder is generally regarded as being the result of an abnormal immune system activation, but the triggers of this abnormal response are unknown. Because cases of the disorder tend to cluster geographically and by season, researchers have suggested that an infection may be involved.
    