Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to craniometaphyseal dysplasia ?
    ### Response:
    Mutations in the ANKH gene cause autosomal dominant craniometaphyseal dysplasia. The ANKH gene provides instructions for making a protein that is present in bone and transports a molecule called pyrophosphate out of cells. Pyrophosphate helps regulate bone formation by preventing mineralization, the process by which minerals such as calcium and phosphorus are deposited in developing bones.
    