Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to peroxisomal acyl-CoA oxidase deficiency ?
    ### Response:
    Peroxisomal acyl-CoA oxidase deficiency is caused by mutations in the ACOX1 gene, which provides instructions for making an enzyme called peroxisomal straight-chain acyl-CoA oxidase. This enzyme is found in sac-like cell structures (organelles) called peroxisomes, which contain a variety of enzymes that break down many different substances.
    