Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to leukocyte adhesion deficiency type 1 ?
    ### Response:
    Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. This gene provides instructions for making one part (the 2 subunit) of at least four different proteins known as 2 integrins. Integrins that contain the 2 subunit are found embedded in the membrane that surrounds white blood cells (leukocytes).
    