Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Fumarase deficiency ?
    ### Response:
    What are the signs and symptoms of Fumarase deficiency? Most newborns with fumarase deficiency show severe neurologic abnormalities, including poor feeding, failure to thrive, and poor muscle tone (hypotonia). Early-onset infantile encephalopathy (altered brain structure or function), seizures, and severe developmental delay with microcephaly are also common.
    