Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Miller syndrome ?
    ### Response:
    Mutations in the DHODH gene cause Miller syndrome. This gene provides instructions for making an enzyme called dihydroorotate dehydrogenase. This enzyme is involved in producing pyrimidines, which are building blocks of DNA, its chemical cousin RNA, and molecules such as ATP and GTP that serve as energy sources in the cell.
    