Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Swyer syndrome ?
    ### Response:
    Mutations in the SRY gene have been identified in approximately 15 percent of individuals with Swyer syndrome. The SRY gene, located on the Y chromosome, provides instructions for making the sex-determining region Y protein. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.
    