Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to autosomal dominant hyper-IgE syndrome ?
    ### Response:
    Mutations in the STAT3 gene cause most cases of AD-HIES. This gene provides instructions for making a protein that plays an important role in several body systems. To carry out its roles, the STAT3 protein attaches to DNA and helps control the activity of particular genes.
    