Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 3-M syndrome ?
    ### Response:
    Mutations in the CUL7 gene cause 3-M syndrome. The CUL7 gene provides instructions for making a protein called cullin-7. This protein plays a role in the cell machinery that breaks down (degrades) unwanted proteins, called the ubiquitin-proteasome system.  Cullin-7 helps to assemble a complex known as an E3 ubiquitin ligase.
    