Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Darier disease ?
    ### Response:
    Mutations in the ATP2A2 gene cause Darier disease. The ATP2A2 gene provides instructions for producing an enzyme abbreviated as SERCA2. This enzyme acts as a pump that helps control the level of positively charged calcium atoms (calcium ions) inside cells, particularly in the endoplasmic reticulum and the sarcoplasmic reticulum.
    