Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to familial osteochondritis dissecans ?
    ### Response:
    Mutation of the ACAN gene can cause familial osteochondritis dissecans. The ACAN gene provides instructions for making the aggrecan protein, which is a component of cartilage. Aggrecan attaches to the other components of cartilage, organizing the network of molecules that gives cartilage its strength.
    