Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Meckel syndrome ?
    ### Response:
    Meckel syndrome can be caused by mutations in one of at least eight genes. The proteins produced from these genes are known or suspected to play roles in cell structures called cilia. Cilia are microscopic, finger-like projections that stick out from the surface of cells and are involved in signaling pathways that transmit information between cells.
    