Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to malignant hyperthermia ?
    ### Response:
    Variations of the CACNA1S and RYR1 genes increase the risk of developing malignant hyperthermia.  Researchers have described at least six forms of malignant hyperthermia susceptibility, which are caused by mutations in different genes. Mutations in the RYR1 gene are responsible for a form of the condition known as MHS1.
    