Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to primary spontaneous pneumothorax ?
    ### Response:
    Mutations in the FLCN gene can cause primary spontaneous pneumothorax, although these mutations appear to be a very rare cause of this condition. The FLCN gene provides instructions for making a protein called folliculin. In the lungs, folliculin is found in the connective tissue cells that allow the lungs to contract and expand when breathing.
    