Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Hypophosphatasia ?
    ### Response:
    What are the signs and symptoms of Hypophosphatasia? The signs and symptoms of hypophosphatasia vary widely and can appear anywhere from before birth to adulthood. The most severe forms of the disorder tend to occur before birth and in early infancy. Hypophosphatasia weakens and softens the bones, causing skeletal abnormalities similar to another childhood bone disorder called rickets.
    