Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 3-methylcrotonyl-CoA carboxylase deficiency ?
    ### Response:
    Mutations in the MCCC1 or MCCC2 gene can cause 3-MCC deficiency. These two genes provide instructions for making different parts (subunits) of an enzyme called 3-methylcrotonyl-coenzyme A carboxylase (3-MCC). This enzyme plays a critical role in breaking down proteins obtained from the diet.
    