Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Anophthalmia plus syndrome ?
    ### Response:
    Anophthalmia plus syndrome (APS) is a very rare syndrome that involves malformations in multiple organs of the body. The most common findings in affected individuals are anophthalmia (absence of one or both eyes) or severe microphthalmia (abnormally small eyes), and cleft lip and/or cleft palate.
    