Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Caffey disease ?
    ### Response:
    A mutation in the COL1A1 gene causes Caffey disease. The COL1A1 gene provides instructions for making part of a large molecule called type I collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon, and skin.
    