Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to autosomal recessive cerebellar ataxia type 1 ?
    ### Response:
    Mutations in the SYNE1 gene cause ARCA1. The SYNE1 gene provides instructions for making a protein called Syne-1 that is found in many tissues, but it seems to be especially critical in the brain. Within the brain, the Syne-1 protein appears to play a role in the maintenance of the cerebellum, which is the part of the brain that coordinates movement.
    