Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Polycystic Kidney Disease ?
    ### Response:
    A gene mutation, or defect, causes polycystic kidney disease. Genes provide instructions for making proteins in the body. A gene mutation is a permanent change in the deoxyribonucleic acid (DNA) sequence that makes up a gene. In most cases of PKD, a person inherits the gene mutation, meaning a parent passes it on in his or her genes.
    