Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy ?
    ### Response:
    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, commonly known as PLOSL, is a progressive disorder that affects the bones and brain. "Polycystic lipomembranous osteodysplasia" refers to cyst-like bone changes that can be seen on x-rays.
    