Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Megalocytic interstitial nephritis ?
    ### Response:
    What causes malakoplakia? The cause of malakoplakia is unknown, but is thought to be associated with immunodeficiency or autoimmune disorders, such as hypogammaglobinlinemia, therapies that suppress the immune system, cancer, a chronic debilitating disorder, rheumatoid arthritis, and AIDS.
    