Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Brody myopathy ?
    ### Response:
    Mutations in the ATP2A1 gene cause Brody myopathy. The ATP2A1 gene provides instructions for making an enzyme called sarco(endo)plasmic reticulum calcium-ATPase 1 (SERCA1). The SERCA1 enzyme is found in skeletal muscle cells, specifically in the membrane of a structure called the sarcoplasmic reticulum.
    