Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Shwachman-Diamond syndrome ?
    ### Response:
    Mutations in the SBDS gene have been identified in about 90 percent of people with the characteristic features of Shwachman-Diamond syndrome. This gene provides instructions for making a protein whose function is unknown, although it is active in cells throughout the body.
    