Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Buschke-Ollendorff syndrome ?
    ### Response:
    Buschke-Ollendorff syndrome results from mutations in the LEMD3 gene. This gene provides instructions for making a protein that helps control signaling through two chemical pathways known as the bone morphogenic protein (BMP) and transforming growth factor-beta (TGF-) pathways.
    