Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hand-foot-genital syndrome ?
    ### Response:
    Mutations in the HOXA13 gene cause hand-foot-genital syndrome. The HOXA13 gene provides instructions for producing a protein that plays an important role in development before birth. Specifically, this protein appears to be critical for the formation and development of the limbs (particularly the hands and feet), urinary tract, and reproductive system.
    