Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to autoimmune polyglandular syndrome, type 1 ?
    ### Response:
    Mutations in the AIRE gene cause autoimmune polyglandular syndrome, type 1.  The AIRE gene provides instructions for making a protein called the autoimmune regulator. As its name suggests, this protein plays a critical role in regulating certain aspects of immune system function.
    