Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) palmoplantar keratoderma with deafness ?
    ### Response:
    Palmoplantar keratoderma with deafness is a disorder characterized by skin abnormalities and hearing loss. Affected individuals develop unusually thick skin on the palms of the hands and soles of the feet (palmoplantar keratoderma) beginning in childhood. Hearing loss ranges from mild to profound.
    