Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to junctional epidermolysis bullosa ?
    ### Response:
    Junctional epidermolysis bullosa results from mutations in the LAMA3, LAMB3, LAMC2, and COL17A1 genes. Mutations in each of these genes can cause Herlitz JEB or non-Herlitz JEB. LAMB3 gene mutations are the most common, causing about 70 percent of all cases of junctional epidermolysis bullosa.
    