Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Generalized Gangliosidoses ?
    ### Response:
    The gangliosidoses are a group of inherited metabolic diseases caused by a deficiency of the different proteins needed to break down fatty substances called lipids. Excess buildup of these fatty materials (oils, waxes, steroids, and other compounds) can cause permanent damage in the cells and tissues in the brain and nervous systems, particularly in nerve cells.
    