Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to multicentric osteolysis, nodulosis, and arthropathy ?
    ### Response:
    MONA results from mutations in the MMP2 gene. This gene provides instructions for making an enzyme called matrix metallopeptidase 2, whose primary function is to cut (cleave) a protein called type IV collagen. Type IV collagen is a major structural component of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues.
    