Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to STING-associated vasculopathy with onset in infancy ?
    ### Response:
    SAVI is caused by mutations in the TMEM173 gene. This gene provides instructions for making a protein called STING, which is involved in immune system function. STING helps produce beta-interferon, a member of a class of proteins called cytokines that promote inflammation.
    