Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to arterial tortuosity syndrome ?
    ### Response:
    Arterial tortuosity syndrome is caused by mutations in the SLC2A10 gene. This gene provides instructions for making a protein called GLUT10. The level of GLUT10 appears to be involved in the regulation of a process called the transforming growth factor-beta (TGF-) signaling pathway.
    