Below is an instruction from Human. Write a response.
    ### Instruction:
    What is the outlook for Charcot-Marie-Tooth Disease ?
    ### Response:
    Onset of symptoms of CMT is most often in adolescence or early adulthood, however presentation may be delayed until mid-adulthood. Progression of symptoms is very gradual. The degeneration of motor nerves results in muscle weakness and atrophy in the extremities (arms, legs, hands, or feet), and the degeneration of sensory nerves results in a reduced ability to feel heat, cold, and pain.
    