Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to congenital leptin deficiency ?
    ### Response:
    Congenital leptin deficiency is caused by mutations in the LEP gene. This gene provides instructions for making a hormone called leptin, which is involved in the regulation of body weight. Normally, the body's fat cells release leptin in proportion to their size.
    