Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pyruvate dehydrogenase deficiency ?
    ### Response:
    The genes involved in pyruvate dehydrogenase deficiency each provide instructions for making a protein that is a component of a group of proteins called the pyruvate dehydrogenase complex. This complex plays an important role in the pathways that convert the energy from food into a form that cells can use.
    