Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Hereditary diffuse leukoencephalopathy with spheroids ?
    ### Response:
    Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a neurological condition characterized by changes to certain areas of the brain. A hallmark of HDLS is leukoencephalopathy, which is damage to a type of brain tissue called white matter. Another common finding is axon damage due to swellings called spheroids.
    