Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cleidocranial dysplasia ?
    ### Response:
    The RUNX2 gene provides instructions for making a protein that is involved in bone and cartilage development and maintenance. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.
    