Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Nakajo-Nishimura syndrome ?
    ### Response:
    Nakajo-Nishimura syndrome is caused by mutations in the PSMB8 gene. This gene provides instructions for making one part (subunit) of specialized cell structures called immunoproteasomes, which are found primarily in immune system cells. Immunoproteasomes play an important role in regulating the immune system's response to foreign invaders, such as viruses and bacteria.
    