Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to distal myopathy 2 ?
    ### Response:
    A mutation in the MATR3 gene has been identified in people with distal myopathy 2. This gene provides instructions for making a protein called matrin 3, which is found in the nucleus of the cell as part of the nuclear matrix. The nuclear matrix is a network of proteins that provides structural support for the nucleus and aids in several important nuclear functions.
    