Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hereditary sensory and autonomic neuropathy type IE ?
    ### Response:
    HSAN IE is caused by mutations in the DNMT1 gene. This gene provides instructions for making an enzyme called DNA (cytosine-5)-methyltransferase 1. This enzyme is involved in DNA methylation, which is the addition of methyl groups, consisting of one carbon atom and three hydrogen atoms, to DNA molecules.
    