Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hyperprolinemia ?
    ### Response:
    Mutations in the ALDH4A1 and PRODH genes cause hyperprolinemia.  Inherited hyperprolinemia is caused by deficiencies in the enzymes that break down (degrade) proline. Hyperprolinemia type I is caused by a mutation in the PRODH gene, which provides instructions for producing the enzyme proline oxidase.
    