Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to factor V Leiden thrombophilia ?
    ### Response:
    A particular mutation in the F5 gene causes factor V Leiden thrombophilia. The F5 gene provides instructions for making a protein called coagulation factor V. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury.
    