Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Alpers-Huttenlocher syndrome ?
    ### Response:
    Alpers-Huttenlocher syndrome is caused by mutations in the POLG gene. This gene provides instructions for making one part, the alpha subunit, of a protein called polymerase gamma (pol ). Pol  functions in mitochondria, which are structures within cells that use oxygen to convert the energy from food into a form cells can use.
    