Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Emanuel syndrome ?
    ### Response:
    Emanuel syndrome is a chromosome disorder that causes problems with physical and intellectual development. Signs and symptoms can vary but may include severe intellectual disability; small head size (microcephaly); failure to thrive; cleft palate or high-arched palate; small jaw (micrognathia); congenital heart defects; and abnormalities of the ears, kidneys, and/or male genitals.
    