Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Holt-Oram syndrome ?
    ### Response:
    Holt-Oram syndrome is a genetic condition characterized by skeletal abnormalities of the hands and arms (upper limbs) and heart problems. Affected people have at least one bone abnormality in the wrist, many of which can be detected only by X-ray. Additional skeletal abnormalities may also be present.
    