Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 3-hydroxy-3-methylglutaryl-CoA lyase deficiency ?
    ### Response:
    Mutations in the HMGCL gene cause HMG-CoA lyase deficiency. The HMGCL gene provides instructions for making an enzyme known as 3-hydroxymethyl-3-methylglutaryl-coenzyme A lyase (HMG-CoA lyase). This enzyme plays a critical role in breaking down dietary proteins and fats for energy.
    