Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to nonbullous congenital ichthyosiform erythroderma ?
    ### Response:
    Mutations in at least three genes can cause NBCIE. These genes provide instructions for making proteins that are found in the outermost layer of the skin (the epidermis). The epidermis forms a protective barrier between the body and its surrounding environment.
    