Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to acromicric dysplasia ?
    ### Response:
    Acromicric dysplasia is caused by mutations in the FBN1 gene, which provides instructions for making a large protein called fibrillin-1. This protein is transported out of cells into the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells.
    