Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to cystic fibrosis ?
    ### Response:
    Mutations in the CFTR gene cause cystic fibrosis. The CFTR gene provides instructions for making a channel that transports negatively charged particles called chloride ions into and out of cells. Chloride is a component of sodium chloride, a common salt found in sweat.
    