Below is an instruction from Human. Write a response.
    ### Instruction:
    How many people are affected by Hermansky-Pudlak syndrome ?
    ### Response:
    Hermansky-Pudlak syndrome is a rare disorder in most populations and is estimated to affect 1 in 500,000 to 1,000,000 individuals worldwide. Type 1 is more common in Puerto Rico, particularly in the northwestern part of the island where about 1 in 1,800 people are affected.
    