Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to CHOPS syndrome ?
    ### Response:
    CHOPS syndrome is caused by mutations in the AFF4 gene. This gene provides instructions for making part of a protein complex called the super elongation complex (SEC). During embryonic development, the SEC is involved in an activity called transcription, which is the first step in the production of proteins from genes.
    