Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hereditary angioedema ?
    ### Response:
    Mutations in the SERPING1 gene cause hereditary angioedema type I and type II. The SERPING1 gene provides instructions for making the C1 inhibitor protein, which is important for controlling inflammation. C1 inhibitor blocks the activity of certain proteins that promote inflammation.
    