Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to incontinentia pigmenti ?
    ### Response:
    Mutations in the IKBKG gene cause incontinentia pigmenti. The IKBKG gene provides instructions for making a protein that helps regulate nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins that helps protect cells from self-destructing (undergoing apoptosis) in response to certain signals.
    