Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to dihydropyrimidinase deficiency ?
    ### Response:
    Dihydropyrimidinase deficiency is caused by mutations in the DPYS gene, which provides instructions for making an enzyme called dihydropyrimidinase. This enzyme is involved in the breakdown of molecules called pyrimidines, which are building blocks of DNA and its chemical cousin RNA.
    