Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) inclusion body myopathy with early-onset Paget disease and frontotemporal dementia ?
    ### Response:
    Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) is a condition that can affect the muscles, bones, and brain.  The first symptom of IBMPFD is often muscle weakness (myopathy), which typically appears in mid-adulthood.
    