Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spondyloenchondrodysplasia with immune dysregulation ?
    ### Response:
    Mutations in the ACP5 gene cause SPENCDI. This gene provides instructions for making an enzyme called tartrate-resistant acid phosphatase type 5 (TRAP). The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells.
    