Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Kniest dysplasia ?
    ### Response:
    Kniest dysplasia is one of a spectrum of skeletal disorders caused by mutations in the COL2A1 gene. This gene provides instructions for making a protein that forms type II collagen. This type of collagen is found mostly in the clear gel that fills the eyeball (the vitreous) and in cartilage.
    