Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Kuskokwim disease ?
    ### Response:
    What are the signs and symptoms of Kuskokwim disease? The range and and severity of signs and symptoms in individuals with Kuskokwim disease can vary, even among siblings. Affected individuals usually have congenital contractures, especially of lower extremities, which progress during childhood and persist for the lifetime of the individual.
    