Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the symptoms of Ichthyosis-mental retardation syndrome with large keratohyalin granules in the skin ?
    ### Response:
    What are the signs and symptoms of Ichthyosis-mental retardation syndrome with large keratohyalin granules in the skin? The Human Phenotype Ontology provides the following list of signs and symptoms for Ichthyosis-mental retardation syndrome with large keratohyalin granules in the skin.
    