Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) CREST syndrome ?
    ### Response:
    CREST syndrome, also known as limited scleroderma, is a widespread connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs. The symptoms involved in CREST syndrome are associated with the generalized form of the disease systemic sclerosis (scleroderma).
    