Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Koolen-de Vries syndrome ?
    ### Response:
    Koolen-de Vries syndrome is caused by genetic changes that eliminate the function of one copy of the KANSL1 gene in each cell. Most affected individuals are missing a small amount of genetic material, including the KANSL1 gene, from one copy of chromosome 17.
    