Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to lactate dehydrogenase deficiency ?
    ### Response:
    Mutations in the LDHA gene cause lactate dehydrogenase-A deficiency, and mutations in the LDHB gene cause lactate dehydrogenase-B deficiency. These genes provide instructions for making the lactate dehydrogenase-A and lactate dehydrogenase-B pieces (subunits) of the lactate dehydrogenase enzyme.
    