Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to 48,XXYY syndrome ?
    ### Response:
    48,XXYY syndrome is a condition related to the X and Y chromosomes (the sex chromosomes). People normally have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics.
    