Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Miller-Dieker syndrome ?
    ### Response:
    Miller-Dieker syndrome is caused by a deletion of genetic material near the end of the short (p) arm of chromosome 17. The signs and symptoms of Miller-Dieker syndrome are probably related to the loss of multiple genes in this region. The size of the deletion varies among affected individuals.
    