Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to branchio-oculo-facial syndrome ?
    ### Response:
    Branchio-oculo-facial syndrome is caused by mutations in the TFAP2A gene. This gene provides instructions for making a protein called transcription factor AP-2 alpha (AP-2). As its name suggests, this protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.
    