Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to CHST3-related skeletal dysplasia ?
    ### Response:
    As its name suggests, CHST3-related skeletal dysplasia results from mutations in the CHST3 gene. This gene provides instructions for making an enzyme called C6ST-1, which is essential for the normal development of cartilage. Cartilage is a tough, flexible tissue that makes up much of the skeleton during early development.
    