Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to hereditary sensory neuropathy type IA ?
    ### Response:
    Mutations in the SPTLC1 gene cause hereditary sensory neuropathy type IA. The SPTLC1 gene provides instructions for making one part (subunit) of an enzyme called serine palmitoyltransferase (SPT). The SPT enzyme is involved in making certain fats called sphingolipids.
    