Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to medullary cystic kidney disease type 1 ?
    ### Response:
    MCKD1 is caused by mutations in the MUC1 gene. This gene provides instructions for making a protein called mucin 1, which is one of several mucin proteins that make up mucus. Mucus is a slippery substance that lubricates the lining of the airways, digestive system, reproductive system, and other organs and tissues and protects them from foreign invaders and other particles.
    