Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to erythrokeratodermia variabilis et progressiva ?
    ### Response:
    EKVP can be caused by mutations in the GJB3 or GJB4 gene. These genes provide instructions for making proteins called connexin 31 and connexin 30.3, respectively. These proteins are part of the connexin family, a group of proteins that form channels called gap junctions on the surface of cells.
    