Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Milroy disease ?
    ### Response:
    Mutations in the FLT4 gene cause some cases of Milroy disease. The FLT4 gene provides instructions for producing a protein called vascular endothelial growth factor receptor 3 (VEGFR-3), which regulates the development and maintenance of the lymphatic system.
    