Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to celiac disease ?
    ### Response:
    The risk of developing celiac disease is increased by certain variants of the HLA-DQA1 and HLA-DQB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system. The HLA-DQA1 and HLA-DQB1 genes belong to a family of genes called the human leukocyte antigen (HLA) complex.
    