Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to sialic acid storage disease ?
    ### Response:
    Mutations in the SLC17A5 gene cause all forms of sialic acid storage disease. This gene provides instructions for producing a protein called sialin that is located mainly on the membranes of lysosomes, compartments in the cell that digest and recycle materials.
    