Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Intrahepatic cholestasis of pregnancy ?
    ### Response:
    What causes intrahepatic cholestasis of pregnancy? Largely, the cause of intrahepatic cholestasis of pregnancy (ICP) is unknown. ICP is present in approximately 1% of pregnancies in the United States. It is thought to be caused by a mixture of genetic, hormonal, and environmental factors.
    