Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Holt-Oram syndrome ?
    ### Response:
    Mutations in the TBX5 gene cause Holt-Oram syndrome. This gene provides instructions for making a protein that plays a role in the development of the heart and upper limbs before birth. In particular, this gene appears to be important for the process that divides the developing heart into four chambers (cardiac septation).
    