Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to leptin receptor deficiency ?
    ### Response:
    Leptin receptor deficiency is caused by mutations in the LEPR gene. This gene provides instructions for making a protein called the leptin receptor, which is involved in the regulation of body weight. The leptin receptor protein is found on the surface of cells in many organs and tissues of the body including a part of the brain called the hypothalamus.
    