Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to systemic lupus erythematosus ?
    ### Response:
    Normal variations (polymorphisms) in many genes can affect the risk of developing SLE, and in most cases multiple genetic factors are thought to be involved. In rare cases, SLE is caused by mutations in single genes. Most of the genes associated with SLE are involved in immune system function, and variations in these genes likely affect proper targeting and control of the immune response.
    