Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Hirschsprung's disease ?
    ### Response:
    What causes Hirschsprung disease? There are a number of different causes of Hirschsprung disease (HSCR). For example, HSCR may occur as: A part of a syndrome In association with a chromosome anomaly (such as trisomy 21 or Down syndrome)  Along with other bi
    