Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) Primrose syndrome ?
    ### Response:
    Primrose syndrome is characterized by severe learning disabilities, bony ear cartilage, a hard bony growth in the roof of the mouth, cystic changes on the top of the upper arm and leg bones, cataracts, hearing loss, adult-onset progressive ataxia and nervous system disease, and brain calcification.
    