Below is an instruction from Human. Write a response.
    ### Instruction:
    What is (are) adult-onset leukoencephalopathy with axonal spheroids and pigmented glia ?
    ### Response:
    Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a neurological condition characterized by changes to certain areas of the brain. A hallmark of ALSP is leukoencephalopathy, which is the alteration of a type of brain tissue called white matter.
    