Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pilomatricoma ?
    ### Response:
    Mutations in the CTNNB1 gene are found in almost all cases of isolated pilomatricoma. These mutations are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. Somatic mutations are not inherited.  The CTNNB1 gene provides instructions for making a protein called beta-catenin.
    