Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to pyruvate carboxylase deficiency ?
    ### Response:
    Mutations in the PC gene cause pyruvate carboxylase deficiency.  The PC gene provides instructions for making an enzyme called pyruvate carboxylase. This enzyme is active in mitochondria, which are the energy-producing centers within cells. It is involved in several important cellular functions including the generation of glucose, a simple sugar that is the body's main energy source.
    