Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to metatropic dysplasia ?
    ### Response:
    Metatropic dysplasia is caused by mutations in the TRPV4 gene, which provides instructions for making a protein that acts as a calcium channel. The TRPV4 channel transports positively charged calcium atoms (calcium ions) across cell membranes and into cells.
    