Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to mevalonate kinase deficiency ?
    ### Response:
    Mutations in the MVK gene cause mevalonate kinase deficiency. The MVK gene provides instructions for making the mevalonate kinase enzyme. This enzyme is involved in the production of cholesterol, which is later converted into steroid hormones and bile acids.
    