Below is an instruction from Human. Write a response.
    ### Instruction:
    What causes Pontocerebellar hypoplasia type 1 ?
    ### Response:
    What causes pontocerebellar hypoplasia type 1? A specific mutations in the VRK1 gene has caused PCH1 in at least one family. Specific mutations in RARS2 and TSEN54 have also been associated with PCH1. TSEN54 mutations were identified in one case from a family with three siblings with PCH1; DNA was only available in one of the three siblings.
    