Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Coats plus syndrome ?
    ### Response:
    Coats plus syndrome results from mutations in the CTC1 gene. This gene provides instructions for making a protein that plays an important role in structures known as telomeres, which are found at the ends of chromosomes. Telomeres are short, repetitive segments of DNA that help protect chromosomes from abnormally sticking together or breaking down (degrading).
    