Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Kabuki syndrome ?
    ### Response:
    Kabuki syndrome is caused by mutations in the KMT2D gene (also known as MLL2) or the KDM6A gene.  Between 55 and 80 percent of cases of Kabuki syndrome are caused by mutations in the KMT2D gene. This gene provides instructions for making an enzyme called lysine-specific methyltransferase 2D that is found in many organs and tissues of the body.
    