Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to adiposis dolorosa ?
    ### Response:
    The cause of adiposis dolorosa is unknown. The condition is thought to have a genetic component because a few families with multiple affected family members have been reported. However, no associated genes have been identified.  Several other possible causes of adiposis dolorosa have been suggested, although none have been confirmed.
    