Below is an instruction from Human. Write a response.
    ### Instruction:
    What is the outlook for Lissencephaly ?
    ### Response:
    The prognosis for children with lissencephaly depends on the degree of brain malformation. Many will die before the age of 10 years. The cause of death is usually aspiration of food or fluids, respiratory disease, or severe seizures. Some will survive, but show no significant development -- usually not beyond a 3- to 5-month-old level.
    