Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to dystrophic epidermolysis bullosa ?
    ### Response:
    Mutations in the COL7A1 gene cause all three major forms of dystrophic epidermolysis bullosa. This gene provides instructions for making a protein that is used to assemble type VII collagen. Collagens are molecules that give structure and strength to connective tissues, such as skin, tendons, and ligaments, throughout the body.
    