Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to spondyloepiphyseal dysplasia congenita ?
    ### Response:
    Spondyloepiphyseal dysplasia congenita is one of a spectrum of skeletal disorders caused by mutations in the COL2A1 gene. This gene provides instructions for making a protein that forms type II collagen. This type of collagen is found mostly in cartilage and in the clear gel that fills the eyeball (the vitreous).
    