Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to PDGFRB-associated chronic eosinophilic leukemia ?
    ### Response:
    PDGFRB-associated chronic eosinophilic leukemia is caused by genetic rearrangements that join part of the PDGFRB gene with part of another gene. At least 20 genes have been found that fuse with the PDGFRB gene to cause PDGFRB-associated chronic eosinophilic leukemia.
    