Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Brugada syndrome ?
    ### Response:
    Brugada syndrome can be caused by mutations in one of several genes. The most commonly mutated gene in this condition is SCN5A, which is altered in approximately 30 percent of affected individuals. This gene provides instructions for making a sodium channel, which normally transports positively charged sodium atoms (ions) into heart muscle cells.
    