Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to short-chain acyl-CoA dehydrogenase deficiency ?
    ### Response:
    Mutations in the ACADS gene cause SCAD deficiency. This gene provides instructions for making an enzyme called short-chain acyl-CoA dehydrogenase, which is required to break down (metabolize) a group of fats called short-chain fatty acids. Fatty acids are a major source of energy for the heart and muscles.
    