Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to epidermolytic hyperkeratosis ?
    ### Response:
    Mutations in the KRT1 or KRT10 genes are responsible for epidermolytic hyperkeratosis. These genes provide instructions for making proteins called keratin 1 and keratin 10, which are found in cells called keratinocytes in the outer layer of the skin (the epidermis).
    