Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to Marinesco-Sjgren syndrome ?
    ### Response:
    Mutations in the SIL1 gene cause Marinesco-Sjgren syndrome. The SIL1 gene provides instructions for producing a protein located in a cell structure called the endoplasmic reticulum. Among its many functions, the endoplasmic reticulum folds and modifies newly formed proteins so they have the correct 3-dimensional shape.
    