Below is an instruction from Human. Write a response.
    ### Instruction:
    What are the genetic changes related to renal hypouricemia ?
    ### Response:
    Mutations in the SLC22A12 or SLC2A9 gene cause renal hypouricemia. These genes provide instructions for making proteins called urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9), respectively. These proteins are found in the kidneys, specifically in structures called proximal tubules.
    