Yes they did.  They made a drug that they knew was addictive (oxycontin) and marketed it heavily to doctors telling them that it wasn't.  So doctors started to prescribe it widely, not realizing how bad it would get.  Automakers have been found liable for making cars that they claimed were safe but exploded on contact.  Ever heard of the Corvair?  Does Big Pharma deserve all of the blame?  No.  But they played a huge role in the problem.