In some ways the US is already isolated by geography and the arrogance of wealth, power, and the certainty of being right. Small but telling signs are: the only country to reject the metric system; a paper currency with a late XIX-th century design; the only major country not to play soccer, the world's sport.  Also notable are an apparently limitless credulity about UFOs, pyramids, vaccinations, evolution, climate change, and much else.  Stop the World: the USA wants to get off.