Positive thinking, staying in good shape, eat healthy, staying hydrated, getting lots of rest are all good to deal with high altitude, except the only way to really deal with high exertion at altitude is to go as early as possible to Wyoming for your body to get acclimated which involves red blood cells adapting to better deal with the decrease in oxygen levels compared to UH players living at sea level.  You can take drugs like Diamox or even Viagra just before game time but not sure if that is legal and might make things worse for some players.  Wyoming might be hurting but if they spread their offense early and consistently throughout the game, eventually many UH defense players are going to be sucking wind, in the 2nd half.  Oxygen on the sidelines and lots of substittions help but the high elevation is one heckuva advantage over Hawaii .  The game is winnable and will be shown on ESPN2 at 4:15pm Hawaii time.