And, to be clear, some of the triggers can be easily managed.   Very easily.   One example would be the fortification of wheat products with synthetic vitamins such as folic acid.  A large percentage of the population can't metabolize the synthetic vitamins easily and it causes health problems and weight gain.

Supplement only as necessary and test appropriately to determine who needs it.   Don't carpet-bomb the whole population with synthetic (non-bioidentical) vitamins when it is doing a significant proportion of them a lot of harm (50% of the population, or more).

By the way, European countries don't fortify their foods to the same degree, and I'm not aware of any that add folic acid, niacin and so on to wheat.   Guess what?   They have fewer problems with obesity, which could tie back to metabolic disturbances induced in many people by these synthetic forms of nutrients.