According to 2014 data, the 17 commonly identified "Middle Eastern" countries have a population of 371 million people. 5 of those are considered by the United States to be "Major Non-NATO Allies", 4 more are countries that actively cooperate with the US on security issues, and a 10th is Israel. So lets be moderate, and suggest half of the 17 are allies of the United States. 

Nevermind nuking the area would be the equivalent of wiping out the entire US population + the entire Canadian population + 17 million more people, because we're really angry at the population of Rhode Island.