This kind of assistance takes less than 1% of the US budget, so it is not fixing the whole world, and I am glad to see lives saved and goodwill created by these programs. Health and education lead to more stable societies that make the world more peaceful and stronger economically, so I think this is an excellent use of our tax resources that benefits us directly. This is the kind of work that keeps our military out of harm's way. Also, the Global Fund operates through grants that often go to charitable organizations or nonprofits that manage specific projects. Even charities need funding from somewhere. It's important to have a coordinated response to huge regional problems like the AIDS epidemic that threaten the stability of a country, and the Global Fund and PEPFAR are big enough to get measurable results.