I would prefer a S&W 500 mag across my chest ... with a slung 358 Springfield M1A!  I haven't hunted game for over 54 years ... I think the last thing I shot was my old Caddy ... had to put the poor thing down, had a burnt out wheel bearing.  As for self-defense against two-legged critters ... I stay away from drugs, hookers, bars, crazies, and I try not to talk anyone into beating me to death.  Soon as someone clenches their fist at me, I call the cops.  If I'm in immediate fear for life or limb, I'm all over them, win, lose, or draw.  If they kill me, my troubles are over, and theirs have just begun.  Life is a gamble ... can't live in fear!  God has numbered my days!