With all due respect to your passion against me, I'm not a one-issue voter at all.  Not that such a thing would be bad when we're talking about the legalized slaughter of innocent human beings, which happens to be in the order of millions now.

If the "one issue" was slavery would you have a problem with me being a one-issue voter?  I doubt it, but I may be wrong.

Anyway, this is my list of absolute non-negotiables that I populated some months ago.
- Right to Life/Anti-abortion
- Right to Life/Anti-euthanasia aka Physician Assisted Suicide
- Right to Life/Anti-embryonic stem cell research
- Right to naturally created Life/Anti-human cloning and/or hybrids
- Full protection of Religious Liberty, which includes defending Sacramental Marriage between a man and a woman only.  Same sex marriages, if won through votes instead of legal manipulations by SCOTUS, can ever only be civil in construction.  God and His True Church do not sanction them.

More could be added, but this is "hot list"