Lets compare this weekends games for the two because it looks like the two had very similar scenarios in terms of running back production and offensive line protection. There are obviously other factors involved but it's a fair comparison in my opinion to see how they responded. 

Broncos running backs had 55 yards on 17 carries, 3.24 YPC. Siemian was sacked five times, hit six times and pressured many others.

Total production, two turnovers, two others turnovers that should have been, zero points and an L.

Eagles running backs averaged 2.56 YPC last night; 64 yards on 25 carries. 
Wentz was sacked three times, hit six times and pressured several other times.  

Total production, 4TD passes, one turnover, 34 points and a W.

This is the difference between a guy ascending toward excellence in Wentz and one that is mediocre at best in Siemian. One put his team on his back and the other did nothing.