Depression? Check.
Minor tumors? Check.
Having children with depression? I considered my personality and decided I'd make a lousy parent. I stress out in stressful situations.
The problem stops with this generation.
Do I worry about no legacy? There's billions of people on this planet. Overpopulation is causing massive problems, children ought to be able to grow up to be their own persons without being saddled with "legacy", so no.