I wonder if this will open the floodgates of opposition.
Well, it seems like healthcare is off the table for the time being (and maybe the year) as the October budget cliff comes into view.  The next question will probably be if there will be any tax cuts/reform this year as time is running out.  Without the expected cuts to healthcare there is less room for any tax cuts in the Senate to pass under procedural rules.
Though it doesn't seem beyond McConnell's restraint to do away with cloture entirely.  Given how he's tried to ramrod this secret, closed-door tax cut and gone to the extreme on the nuclear option that the Democrats were unwilling to go it would be entirely possible.