Iodixanol
Intravascular injection of iodixanol opacifies vessels in the path of flow of the contrast agent, permitting visualization of internal structures. In imaging of the body, iodinated contrast agents diffuse from the vascular into the extravascular space. In a normal brain with an intact blood-brain barrier, contrast does not diffuse into the extravascular space. In patients with a disrupted bloodbrain barrier, contrast agent accumulates in the interstitial space in the region of disruption.
In concentrations of 270 and 320 mg of organically bound iodine per mL (550 mg and 642 ml of Iodixanol per mL)
Individualize the combination of volume and concentration of Iodixanol Injection considering age, body weight, size of the vessel, rate of blood flow within the vessel, and other applicable factors. For the adult patients, the maximum recommended total dose of iodine is 80 grams. Patients should be adequately hydrated prior to and following the intravascular administration of iodinated contrast agents.
Not indicated for intrathecal use
Most common adverse reactions (incidence greater than 0.5%) in adult patients after Dixanol injection: Discomfort, warmth, painCardiovascular: angina. Gastrointestinal: diarrhea, nausea, vomiting.Nervous System: agitation, anxiety, insomnia, nervousness, dizziness, headache, migraine, unusual skin sensations, sensory disturbance, fainting, sensation of spinning.Skin: itchy rash, severe itching, hives.Special Senses: Smell, taste, and vision alteration. Pediatric patients experienced similar adverse reactions.
Pregnancy:There are no data with iodixanol use in pregnant women to inform any drug-associated risks.Lactation: A lactating woman may pump and discard breast milk for 10 hours after Iodixanol administration
Hypersensitivity Reactions: life-threatening or fatal reactions can occur. Always have emergency equipment and trained personnel available.Contrast Induced Acute Kidney Injury: Acute injury including renal failure can occur. Minimize dose and maintain adequate hydration to minimize risk.Cardiovascular reactions: hemodynamic disturbances including shock and cardiac arrest may occur during or after administration.
The adverse effects of overdosage of any contrast agent may be life-threatening and affect mainly the pulmonary and cardiovascular systems. Treatment of an overdosage is directed toward the support of all vital functions and prompt institution of symptomatic therapy. Dixanol Injection does not bind to plasma or serum protein and can be dialyzed.
Contrast medium for diagnostic procedures
Store Dixanol at controlled room temperature, 20°C-25°C; excursions permitted to 15°C-30°C
Geriatrics: Exercise caution in dose selection for elderly patientsPediatric Use: The safety and efficacy of Dixanol have been established in pediatric patients down to birth for angiocardiography, cerebral arteriography, visceral arteriography, CT imaging of the head and body, and excretory urography. The safety and efficacy of Dixanol have also been established in pediatric patients 12 years and older for intra-arterial digital subtraction angiography, peripheral arteriography, CT imaging peripheral venography and CCTA.
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