Insulin Aspart has a faster onset and a shorter duration of action than soluble human insulin. Due to the faster onset of action, Insulin Aspart should generally be given immediately before a meal. When necessary Insulin Aspart may be given soon after a meal.Dosage of Insulin Aspart is individual and determined on the basis of the physician's advice in accordance with the needs of the patient. It should normally be used in combination with long-acting insulin given at least once a day.The individual insulin requirement is usually between 0.5 and 1.0 IU/kg/day in adults and children over 2 years of age. In a meal-related treatment 50-70% of this requirement may be provided by Insulin Aspart and the remainder by long-acting insulin. Adjustment of dosage may also be necessary if patients undertake increased physical activity or change their usual diet. Exercise taken immediately after a meal may increase the risk of hypoglycaemia.Subcutaneous Injection: Insulin Aspart should be administered by subcutaneous injection in the abdominal region, buttocks, thigh, or upper arm. Because Insulin Aspart has a more rapid onset and a shorter duration of activity than human regular insulin, it should be injected immediately (within 5-10 minutes) before a meal Continuous Subcutaneous Insulin Infusion (CSII) by External Pump Insulin Aspart can also be infused subcutaneously by an external insulin pump. The initial programming of the external insulin infusion pump should be based on the total daily insulin dose of the previous regimen. Approximately 50% of the total dose is usually given as meal-related boluses of Insulin Aspart and the remainder is given as a basal infusion. When used with an infusion pump Insulin Aspart should not be mixed with any other insulin.Intravenous Use: Insulin Aspart can be administered intravenously under medical supervision for glycemic control with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia. For intravenous use, Insulin Aspart should be used at concentrations from 0.05 IU/mL to 1.0 IU/mL insulin aspart in infusion systems using polypropylene infusion bags. Insulin Aspart has been shown to be stable in infusion fluids such as 0.9% sodium chloride.
Insulin Aspart [Protamine Crystallised]
The primary activity of Insulin Aspart is the regulation of glucose metabolism. Insulin Aspart bind to the insulin receptors on muscle and fat cells and lower blood glucose by facilitating the cellular uptake of glucose and simultaneously inhibiting the output of glucose from the liver.
Each ml solution contains 100 IU (equivalent to 3.50 mg) Insulin Aspart (rDNA).
Instructions to be given to the patient before injecting this Insulin:According to the instruction given with ConviPen, insert the cartridge into the pen correctly & equip the needleGently turn the pen upside down for 8-10 times until the insulin in the cartridge becomes uniformly mixed suspensionRemove the needle cap, discharge air bubbles in the catridgeAdjust the dosage button to get correct dose & inject to the specific siteIn order to avoid cross contamination, do not let the needle touch anything during the process of preparation.
A number of drugs affect glucose metabolism and may require dose adjustment.The following substances may reduce the Insulet ASP as well as Insulet ASP requirements: Oral anti-diabetic products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, propoxyphene, pentoxifylline, salicylates and sulfonamide antibiotics.The following substances may increase the Insulet ASP as well as Insulet ASP requirements: Thiazides, glucocorticoids, thyroid hormones, beta-sympathomimetics, growth hormone and danazol. Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood glucose lowering effect of insulin.
Side effects of Insulet ASP are hypoglycemia, allergic reactions, injection site reaction, lipodystrophy, pruritus and rash.
Pregnancy category B. There are no restrictions on treatment with Protamine Crystallised Insulin Aspart during lactation. Insulin treatment of the nursing mother should not affect the baby. However, dosage may need to be adjusted.
Dose adjustment and monitoring: Blood glucose should be monitored in all patients treated with insulin. Insulet ASP regimens should be modified cautiously and only under medical supervision
A specific overdose for insulin cannot be defined, however, hypoglycaemia may develop over sequential stages if too high doses relative to the patient’s requirement are administered. Mild hypoglycaemic episodes can be treated by oral administration of glucose or sugary products. Severe hypoglycaemic episodes, where the patient has become unconscious, can be treated by glucagon (0.5 to 1 mg) given intramuscularly or subcutaneously. Glucose must also be given intravenously if the patient does not respond to glucagon within 10 to 15 minutes. Upon regaining consciousness administration of oral carbohydrate is recommended for the patient in order to prevent relapse.
Rapid Acting Insulin
Store at 2°C to 8°C in a refrigerator. Do not freeze. Protect from light.
{'Indications': 'Protamine Crystallised Insulet ASP is an insulin analog indicated to improve glycemic control in patients with diabetes mellitus.', 'Description': 'Insulet ASP rDNA is a sterile, clear solution of Insulet ASP human insulin analogue for subcutaneous injection/infusion or intravenous injection. This is a blood glucose lowering agent with an earlier onset of action. It produces a more rapid onset of action compared to soluble human insulin. Insulet ASP is homologous with regular human insulin with the exception of a single substitution of the amino acid Proline by aspartic acid in position B28, and is produced by recombinant DNA technology.'}