Azithromycin Dihydrate (Ophthalmic)
এক বছরের শিশু এবং প্রাপ্তবয়স্ক: প্রথম ২ দিনের জন্য প্রতিদিন আক্রান্ত চোখে ১ ফোঁটা করে দুবার এবং পরবর্তী ৫ দিনের জন্য প্রতিদিন একবার।পেডিয়াট্রিক ব্যবহার: ১ বছরের কম বয়সী শিশু রোগীদের ক্ষেত্রে অ্যাজিথ্রোমাইসিন আই ড্রপ এর নিরাপত্তা ও কার্যকারিতা প্রতিষ্ঠিত হয়নি।এক বছরের কম বয়সী শিশু: প্রস্তাবিত নয়।
জিবেক আই ড্রপ CDC করিনেফর্ম গ্রুপ জি, হেমোফাইলাস ইনফ্লুয়েঞ্জা, স্ট্যাফাইলোকক্কাস অরিয়াস, স্ট্রেপ্টোকক্কাস মাইটিস গ্রুপ এবং স্ট্রেপ্টোকক্কাস নিউমোনিয়া দ্বারা সৃষ্ট ব্যাকটেরিয়াল কনজেক্টিভাইটিস চিকিত্সার জন্য নির্দেশিত।
চোখের জ্বালা, কন্টাক্ট ডার্মাটাইটিস, কর্নিয়ার ক্ষয়, শুষ্ক চোখ, পাঞ্চটেট কেরাটাইটিস ইত্যাদি।
Azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility.Azithromycin's half-life allows a large single dose to be administered and yet maintain bacteriostatic levels in the infected tissue for several days. Following a single 500 mg dose, plasma concentrations of azithromycin declined in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min and a terminal elimination half life of 68 hours. The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues. Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. Over the course of a week, approximately 6% of the administered dose appears as unchanged drug in urine.Microbiology: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Azithromycin has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections:Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenesAerobic and facultative gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeaeOther microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis , Mycoplasma pneumoniae , Betalactamase production should have no effect on azithromycin activity.Aerobic and facultative gram-positive microorganisms: Streptococci (Groups C,F,G), Viridans group streptococciAerobic and facultative gram-negative microorganisms: Bordetella pertussis, Legionella pneumophilaAnaerobic microorganisms: Peptostreptococcus species, Prevotella bivia
Children of one year of age and adults: Instill 1 drop in affected eye(s) twice daily for the first 2 days then once daily for the next 5 days.Pediatric Use: The safety and effectiveness of Azithromycin Eye Drops in pediatric patients below 1 year of age have not been established.Children less than one year of age: Not recommended.
Drug interaction studies have not been conducted with Zibac Eye Drops.
Hypersensitivity to any component of the preparation.
Eye irritation, contact dermatitis, corneal erosion, dry eye, punctate keratitis etc.
Pregnancy Category B. In the animal studies, no evidence of harm to the fetus due to Azithromycin was found. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Azithromycin should be used during pregnancy only if clearly needed. It is not known whether Azithromycin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Azithromycin is administered to a nursing woman.
Zibac Eye Drops is indicated for topical ophthalmic use only and should not be administered systemically, injected subconjunctivally, or introduced directly into the anterior chamber of the eye.
Macrolides
Store unopened bottle under refrigeration at 2°C to 8°C. Once the bottle is opened, store it at 25°C for up to 14 days. Discard after the 14 days of opening.
{'Indications': 'Zibac Eye Drops is indicated for the treatment of bacterial conjunctivitis caused by CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumonia.'}