Desvenlafaxine Succinate
ডেসভেনলাফ্যাক্সিন সাক্সিনেট-এর প্রস্তাবিত ডোজ হল ৫০ মিগ্রা দৈনিক একবার, খাবারের সাথে বা খাবার ছাড়া। ক্লিনিক্যল গবেষণায়, ৫০-৪০০ মিগ্রা/দিনের ডোজ কার্যকর হিসেবে পাওয়া গেছে। থেরাপি বন্ধ করার সময়, বন্ধ করার লক্ষণগুলি কমিয়ে আনার জন্য ধীরে ধীরে ডোজ কমানোর পরামর্শ দেওয়া হয়। ডেসভেনলাফ্যাক্সিন সাক্সিনেট প্রতিদিন প্রায় একই সময়ে গ্রহণ করা উচিত। ট্যাবলেটগুলি অবশ্যই পর্যাপ্ত পানির সহ সম্পূর্ণ গিলতে হবে এবং বিভক্ত, চূর্ণ, চিবানো বা দ্রবীভূত করা যাবে না।
হ্যাপিট্যাব মেজর ডিপ্রেসিভ ডিসঅর্ডার (MDD) এর চিকিৎসায় নির্দেশিত। এটা সাধারণত একমত যে মেজর ডিপ্রেসিভ ডিসঅর্ডারের তীব্রতায় কয়েক মাস বা তার বেশি সময় ধরে ফার্মাকোলজিক থেরাপির প্রয়োজন হয়। ক্রমাগত চিকিত্সার প্রয়োজনীয়তা নির্ধারণের জন্য রোগীদের পর্যায়ক্রমে পুনরায় পর্যবেক্ষণ করা উচিত।
বমিবমি ভাব, মাথা ঘোরা, অনিদ্রা, হাইপারহাইড্রোসিস, কোষ্ঠকাঠিন্য, তন্দ্রা, ক্ষুধা হ্রাস, উদ্বেগ, শুষ্ক মুখ এবং নির্দিষ্ট পুরুষ যৌন ফাংশন ব্যাধি।
আলো ও আর্দ্রতা থেকে দূরে, ৩০ ডিগ্রী সেঃ তাপমাত্রার নীচে রাখুন। শিশুদের নাগালের বাইরে রাখুন।
Desvenlafaxine is a synthetic form of the isolated major active metabolite of Venlafaxine, and is categorized as a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). It works by blocking the transporter reuptake protein for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are Serotonin (5-hydroxytryptamine) and Norepinephrine (Noradrenaline). It is approximately 10 times more potent at inhibiting Serotonin uptake than Norepinephrine uptake.The exact mechanism of the antidepressive action of Desvenlafaxine is unknown, but is thought to be related to the potentiation of Serotonin and Norepinephrine in the central nervous system, through inhibition of their reuptake. Non-clinical studies have shown that Desvenlafaxine is a potent Serotonin and Norepinephrine Reuptake Inhibitor (SNRI).
The recommended dose for Desvenlafaxine Succinate is 50 mg once daily, with or without food. In clinical studies, doses of 50-400 mg/day were shown to be effective. When discontinuing therapy, gradual dose reduction is recommended whenever possible to minimize discontinuation symptoms. Desvenlafaxine Succinate should be taken at approximately the same time each day. Tablets must be swallowed whole with fluid and not divided, crushed, chewed, or dissolved.
Clinical studies have shown that Hapytab does not have a clinically relevant effect on CYP2D6 (e.g., Desipramine, Atomoxetine, Dextromethorphan, Metoprolol, Nebivolol, Perphenazine, Tolterodine) metabolism at the dose of 100 mg daily. Reduce the dose of these substrates by one-half if co-administered with 400 mg of Hapytab. Avoid use of Hapytab with other Hapytab-containing products or Venlafaxine products. The concomitant use of Hapytab with other Hapytab-containing products or Venlafaxine will increase Hapytab blood levels and increase dose-related adverse reactions. Like CNS acting drugs, patients should be advised to avoid alcohol consumption while taking Hapytab.
Hypersensitivity to Desvenlafaxine Succinate, Venlafaxine Hydrochloride or to any excipients in the Desvenlafaxine formulation. The use of MAOIs (Mono Amine Oxidase Inhibitors) intended to treat psychiatric disorders with Desvenlafaxine or within 7 days of stopping the treatment with Desvenlafaxine is contraindicated. The use of Desvenlafaxine within 14 days of stopping MAOI intended to treat psychiatric disorders is also contraindicated.
Nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, anxiety, dry mouth and specific male sexual function disorders.
Pregnancy Category C. Desvenlafaxine should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. Desvenlafaxine (O-desmethylvenlafaxine) is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Desvenlafaxine a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Patients with Major Depressive Disorder (MDD) both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether they are taking antidepressant medications or not and this risk may persist until significant remission occurs. Pooled analysis of short-term placebo-controlled studies of antidepressant drugs (SSRIs and others) showed that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents and young adults (aged 18 to 24) with Major Depressive Disorder (MDD) and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24.
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Dosage Adjustment in Renal Impairment: No dosage adjustment is necessary in patients with mild renal impairment. The recommended dose in patients with moderate renal impairment is 50 mg per day. The recommended dose in patients with severe renal impairment or End-Stage Renal Disease (ESRD) is maximum 50 mg every other day. Supplemental dose should not be given to patients after dialysis. The dose should not be escalated in patients with moderate or severe renal impairment or ESRD.Dosage Adjustment in Hepatic Impairment: The recommended dose in patients with hepatic impairment is 50 mg/day. Maximum 100 mg/day is not recommended.
{'Indications': 'Hapytab is indicated for the treatment of Major Depressive Disorder (MDD). It is generally agreed that acute episodes of major depressive disorder require several months or longer of sustained pharmacologic therapy. Patients should be periodically reassessed to determine the need for continued treatment.'}