Saya Ganglioside GT1b (59247-13-1) Masu kera - Phcoker
Masanin kimiyyar Jamus Ernst Klenk ya fara amfani da sunan Ganglioside a cikin 1942 zuwa sabon keɓaɓɓen lebids daga ƙwayoyin ganglion kwakwalwa… ..
Ganglioside GT1b Sfasali
Chemical Name GANGLIOSIDE GT1B TRISODIUM SALT; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) daga kwakwalwa bovine; trisialoganglioside-gt1b daga kwakwalwa bovine; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + gishiri)
kwayoyin Formula C95H162N5Na3O47
kwayoyin Weight 2158.4 g / mol
solubility DMSO: mai narkewa
Aikace-aikace Magunguna; ilimin halittar jini;
Mene ne Ganglioside GT1b?
Masanin kimiyyar Jamus Ernst Klenk ne ya fara amfani da sunan Ganglioside a cikin 1942 ga sababbin keɓaɓɓun lipids daga ƙwayoyin ƙwaƙwalwar ƙwaƙwalwa. Shi kwayaine mai dauke da glycosphingolipids (yumbu da oligosaccharides) da daya ko fiye sialic acid da aka danganta da sarkar sukari. Abun haɗin membrane na cytoplasmic shine ke daidaita abubuwan da suka faru na siginar siginar salula. Fiye da nau'ikan gangliosides 60 an san su, kuma babban bambanci tsakanin su shine matsayi da adadin ragowar NANA.
Ganglioside GT1b yana daya daga cikin lan wasan gangliosides kuma shine trisialic ganglioside tare da ragowar sialic acid biyu waɗanda aka danganta da sashin galactose na ciki. Yana da tasiri mai hana aiki akan amsawar rigakafin jikin mutum. A 0.1-10 μM, zai iya hana samarwar ta hanyar kwatsam na IgG, IgM da IgA ta hanyar kwayoyin mononuclear na mutum. Ganglioside GT1b an kuma gabatar dashi a matsayin mai karbar bakuncin masu karbar bakuwar kwayar cutar shan inna ta Merkel kuma a matsayin wata hanyar da zata iya haifarda cututtukan da ke haifar da kwayoyin cutar Merkel.
Ganglioside GT1b shima yana tasiri a cikin cututtukan da yawa a cikin kansa kuma ana ɗaukarsa a matsayin ƙungiya mai haɗari da ke haɗuwa da ƙwayoyin kwakwalwa. Nazarin sun gano cewa GM1, GD1a, da GT1b suna da tasirin sakamako akan siginar mai karɓar ƙwayar epidermal da kuma ƙaura da ƙaura keratinocytes, kuma kasancewar su na iya zama mai mahimmancin kayan tarihi don kimanta yiwuwar ƙwaƙwalwar kwakwalwa.
Ganglioside GT1b shima yana shafar tsarin rigakafi. Ganglioside GT1b yana da tasirin illa ga amsawar rigakafin jikin mutum kuma yana hana immunoglobulins samar da ƙwayoyin mononuclear na mutum. Akwai shaidun cewa GD1b, GT1b, da GQ1b na iya haɓaka aikin samar da cytokines na Th1 ta hana ayyukan adenylate cyclase, yayin da ke hana samar da Th2.
A matsayin mai karɓar mai karɓar abubuwa daban-daban na tsarin oligosaccharide, ganglioside GT1b shine mai karɓa ta hanyar Clostridium botulinum kwayoyin botulinum neurotoxin shiga cikin ƙwayoyin jijiya. Nazarin ya nuna cewa tetanus toxin ya shiga cikin ƙwayoyin jijiya ta hanyar haɗuwa da GT1b da sauran ƙwayoyin gangliosides, yana hana sakin neurotransmitters a cikin tsarin juyayi na tsakiya, kuma yana haifar da cututtukan ƙwayar cuta. Nau'in botulinum C neurotoxin da ke shiga cikin jijiya ya bincika yiwuwar tasirin apoptotic na sel waɗanda ƙwayoyin ganglioside GT1b suka haifar akan neuroblastoma.
Bugu da ƙari, ganglioside GT1b ya ba da mummunar daidaita motsi na sel, watsawa, da manne wa fibronectin (FN) ta hanyar hulɗar kwayoyin kai tsaye tare da the5 subunit na α5β1 integrin, binciken da za a iya amfani da shi don haɓaka hanyoyin kwantar da hankali. Haɗin GT1b da MAG a saman farji na neurons na iya daidaita tsarin hulɗar da GT1b a cikin ƙwayoyin plasma na neurons, wanda ke haifar da hana ci gaban ƙwayoyin neurite.
Fa'idodin Ganglioside GT1b
Ganglioside GT1b shine glycosphingolipid na acidic wanda ke samar da tasoshin lipid a cikin ƙwayoyin jijiyoyi na tsakiya kuma yana shiga yaduwar sel, rarrabuwa, mamayewa, yaduwar sigina, hulɗar sel zuwa sel, tumorigenesis, da metastasis.
Amsar autoimmune ga gangliosides na iya haifar da cutar Guillain-Barre. Ganglioside GT1b yana haifar da lalacewar ƙwayar ƙwayar cuta ta dopaminergic, wanda zai iya ba da gudummawa ga farawa ko haɓakar cutar ta Parkinson.
Ganglioside GT1b shine mai tunkarar radadin radadin OH, wanda ke kare kwakwalwa daga lalacewar mtDNA, tashin-hankali da kuma tsinkayar lipid wanda ya haifar da matattarar oxygen.
Cutar kumburin Ehrlich tana bayyana ganglioside GT1b, kuma anti-GT1b yana da babbar damar warkewar wannan cutar. Wannan ganglioside shima yana da alaƙa da cutar Miller Fisher.
Hanyoyi na ciki Ganglioside GT1b
Gangliosides na iya ɗaure wa lectins, aiki azaman rigakafi da masu karɓa na cell, shiga cikin siginar tantanin halitta, ƙwayar carcinogenesis da bambancin tantanin halitta, shafar haɓakar ƙwayar cuta da haɓaka jijiya, shiga cikin myelin kwanciyar hankali da farfadowa na jijiya, kuma suna aiki azaman ƙwayoyin cuta da kuma shiga mai guba na gubobi cikin sel .
Tarin tarin ƙwayoyin ganglioside GT1b an alakanta shi da wasu cututtuka da suka haɗa da cutar Thai-Sachs da cutar Sandhof.
Ganglioside GT1b yana hana antigen ko mitogen-induced cell ta hanyar yaduwar ƙwayar cuta kuma an gano shi azaman mai karɓar ƙwayar guba mai guba, ƙarancin guba ne tare da mummunan sakamako.
Ganglioside GT1b yana kusan kusan musamman a cikin ƙwayoyin jijiya kuma an bayyana shi a cikin adventitia. GT1b yana haɓaka bambancin neuronal da haɓakar dendritic, wanda ke haifar da rashin damuwa da haɓaka hyperalgesia da allodynia.
Ganglioside GT1b na iya shafar tsarin rigakafi. Yana da tasiri mai hana aiki a kan martanin mutum na mutumtaka da kuma magance rigakafin immunoglobulin wanda aka samar da ƙwayoyin mononuclear na mutum.
A cikin ƙari, Ganglioside GT1b yana da alaƙa da cututtukan da ke gaba: mura, guillain-garré syndrome, kwalara, tetanus, botulism, kuturta da kiba.
Erickson, KD, Garcea, RL, da Tsai, B. Ganglioside GT1b mai karɓar rakiyar garkuwa ce ta ƙwayar cuta ta Merkel cell polyomavirus. Journal of Virology 83 (19), 10275-10279 (2009).
Kanda, N., da Tamaki, K. Ganglioside GT1b suna hana samarwar immunoglobulin ta hanyar kwayoyin mononuclear na mutum. Immunology 96 (4), 628-633 (1999).
Schengrund, C.-L., DasGupta, BR, da Ringler, NJ Bindingin botulinum da neurotoxins na tetanus zuwa ga ganglioside GT1b da kuma abubuwan da suka samo asali. J. Neurochem. 57 (3), 1024-1032 (1991).
Gangliosides, tsari, abin da ya faru, ilmin halitta da bincike ”. Laburaren Lipid. Americanungiyar Chemists ta Amurka. An makale daga asalin akan 2009-12-17.
Nicole Gaude, Journal of Kwayoyin halitta, Vol. 279: 33 p. 34624-34630, 2004.
Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, da dai sauransu Biosynthesis na manyan ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar GD1a da GT1b. Glycobiology, juz'i na 22, fitowa ta 10, Oktoba 2012, Shafi na 1289–
Bidiyo na Ganglioside GT1b (59247-13-1)