Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial. Weight reduction effects of a black soy peptide supplement in overweight and obese subjects: double blind, randomized, controlled study. Effectiveness of a soy-based compared with a traditional low-calorie diet on weight loss and lipid levels in overweight adults. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Effect of Soymilk Consumption on Waist Circumference and Cardiovascular Risks among Overweight and Obese Female Adults Effect of soy drink replacement in a weight reducing diet on anthropometric values and blood pressure among overweight and obese female youths. Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6- to 18-month-old moderately underweight children in rural Malawi. Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial. Effects of consuming a high‐protein diet with or without soy protein during weight loss and maintenance: a non‐inferiority, randomized clinical efficacy trial Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects. Soy product and isoflavone intakes are associated with a lower risk of type 2 diabetes in overweight Japanese women. Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects A 2-year soy intervention in premenopausal women does not change mammographic densities. The effects of a soy rich diet on serum lipids: the Menfis randomized trial. Effect of soy-based breakfast cereal on blood lipids and oxidized low-density lipoprotein.
SCOPE Studies have suggested that food rich in dietary fiber may facilitate body weight loss , lower total and LDL-cholesterol levels , and reduce body fat . This study examined the effects of soy fiber ( SF ) on body weight , body composition , and blood lipids in overweight and obese participants . METHODS AND RESULTS Thirty-nine overweight and obese college adults ( 19 - 39 years of age ) were r and omly assigned to consume control biscuits or biscuits supplemented with SF for their breakfast for 12 wk ( approximately 100 g/day ) . There were significant differences in changes on body weight , BMI , and LDL-cholesterol ( LDL-C ) between the two groups after 12-wk intervention ( p < 0.05 ) . The changes of body weight , BMI , waist circumference , diastolic blood pressure , serum levels of total cholesterol , LDL-C , and glucose , body fat , and trunk fat of participants in SF group were observed significantly after 12 wk . CONCLUSION SF had favorable effects on body weight , BMI , and fasting LDL-C levels in overweight and obese adults . These effects may be beneficial in antiobesity and the improvement of hyperlipidemia and hypertension ( Clinical Trials.gov registration number-NCT01802840 ) The present study determined the effect of black soy peptide supplementation on body weight and body fat in overweight/obese subjects . In a double-blind controlled trial , participants ( n = 80 ) were r and omized to either soy peptide supplementation ( the test group ) or to a placebo ( the placebo group ) . Sixty-four people completed the study , and anthropometric parameters , serum inflammatory markers , and leptin and lipid profiles  were measured . After 6 weeks , the test group ( n = 35 ) had significant reductions in body weight ( p = 0.003 ) and body mass index ( BMI ) ( p = 0.004 ) , body fat mass ( p = 0.038 ) . After 12 weeks , they also had significant reductions in body weight ( p < 0.001 ) , BMI ( p < 0.001 ) , body fat percentage ( p = 0.002 ) , and body fat mass ( p = 0.001 ) . However , these significance s were not observed in the placebo group ( n = 29 ) . In addition , net changes in body weight and body fat mass in the test group were significantly bigger than those in the placebo group after 12 weeks . Leptin levels were significantly reduced in the test groups ( p = 0.047 ) , but were not observed in the placebo group ( p = 0.323 ) . Interestingly , the subjects with weight reductions ≥1 kg in the test group had greater reductions in circulating leptin levels ( p = 0.002 ) . Additionally , fasting insulin levels were significantly reduced in the test groups . The conclusion is that black soy peptide supplementation may be beneficial for body weight control in overweight/obese subjects OBJECTIVE This study investigated the effects of a soy-based low-calorie diet on weight control , body composition , and blood lipid profiles compared with a traditional low-calorie diet . METHODS Thirty obese adults ( mean body mass index 29 - 30 kg/m(2 ) ) were r and omized to two groups . The soy-based low-calorie group consumed soy protein as the only protein source , and the traditional low-calorie group consumed two-thirds animal protein and the rest plant protein in a 1200 kcal/d diet for 8 wk . A diet record was kept everyday throughout the study . Food intake was analyzed before and after the study . Anthropometric data were acquired every week , and biochemical data from before and after the 8-wk experiment were compared . RESULTS Body weight , body mass index , body fat percentage , and waist circumference significantly decreased in both groups ( P < 0.05 ) . The decrease in body fat percentage in the soy group ( 2.2 % , 95 % confidence interval 1.6 - 2.8 ) was greater than that in the traditional group ( 1.4 % , 95 % confidence interval -0.1 to 2.8 ) . Serum total cholesterol concentrations , low-density lipoprotein cholesterol concentrations , and liver function parameters decreased in the soy-based group and were significantly different from measurements in the traditional group ( P < 0.05 ) . No significant change in serum triacylglycerol levels , serum high-density lipoprotein cholesterol levels , and fasting glucose levels was found in the soy or traditional group . CONCLUSION Soy-based low-calorie diets significantly decreased serum total cholesterol and low-density lipoprotein cholesterol concentrations and had a greater effect on reducing body fat percentage than traditional low-calorie diets . Thus , soy-based diets have health benefits in reducing weight and blood lipids Objective : To assess the efficacy and safety of a low calorie soy-based meal replacement program for the treatment of obesity . Design : A 12-week prospect i ve r and omized controlled clinical trial . Setting : Outpatient weight control research unit . Subjects : One hundred obese ( 28 < BMI ≤41 kg/m2 ) volunteers between the ages of 35 and 65 y. Seventy-four participants completed the trial . Interventions : Participants were r and omized to either the meal replacement treatment group ( n=50 ; 240 g/day , 1200 kcal/day ) or control group ( n=50 ) . Both groups at baseline received a single dietary counseling session and a pamphlet describing weight loss practice s . Main outcome measures : Weight , body fat , serum lipid concentrations . Results : By intent-to-treat analysis , the treatment group lost significantly more weight than the control group ( 7.00 vs 2.90 kg ; P<0.001 ) and had a greater change in total ( 22.5 vs 6.8 mg/dl ; P=0.013 ) and LDL cholesterol ( 21.2 vs 7.1 mg/dl ; P<0.009 ) . Among completers only , the treatment group again lost more weight ( 7.1 kg ; n=37 vs 2.9 kg ; n=37 ; P=0.0001 ) and had a greater reduction in total cholesterol ( 26.1 mg/dl ; n=37 vs 6.7 mg/dl ; P=0.0012 ) and a greater change in LDL cholesterol ( 21.6 vs 5.5 mg/dl ; P=0.0025 ) . ( For any given degree of weight loss , the reduction in LDL cholesterol was significantly greater in the treatment group . ) Treatment was well tolerated and no serious side effects were detected . Conclusions : Use of this soy-based meal replacement formula was effective in lowering body weight , fat mass and in reducing LDL cholesterol beyond what could be expected given the weight lost . Sponsorship : This research was funded by Nutripharma . Dr Allison is a member of the United Soybean Board 's Scientific Advisory Panel and Chair of the Research Grants Committee OBJECTIVE To investigate the effect of soy protein supplementation with known levels of phytoestrogens on cardiovascular disease risk factors and menopausal symptoms in perimenopausal women . METHODS A r and omized , double-blind crossover trial was conducted in 51 women consuming isocaloric supplements containing 20 g of complex carbohydrates ( comparison diet ) , 20 g of soy protein containing 34 mg of phytoestrogens given in a single dose , and 20 g of soy protein containing 34 mg of phytoestrogens split into two doses .  Women were r and omly assigned to one of the three diets for 6-week periods and subsequently were r and omized to the remaining two interventions to determine whether differences existed between the treatment diets for cardiovascular disease risk factors , menopausal symptoms , adherence , and potential adverse effects . RESULTS Significant declines in total cholesterol ( 6 % lower ) and low density lipoprotein cholesterol ( 7 % lower ) were observed in both soy diets compared with the carbohydrate placebo diet . A significant decline in diastolic blood pressure ( 5 mm Hg lower ) was noted in the twice-daily soy diet , compared with the placebo diet . Although nonsignificant effects were noted for a number of measures of quality of life , a significant improvement was observed for the severity of vasomotor symptoms and for hypoestrogenic symptoms in the twice-daily group compared with the placebo group . No significant effects were noted for triglycerides , high density lipoprotein cholesterol or frequency of menopausal symptoms . Adherence was excellent in all groups . CONCLUSIONS Soy supplementation in the diet of nonhypercholesterolemic , nonhypertensive , perimenopausal women result ed in significant improvements in lipid and lipoprotein levels , blood pressure , and perceived severity of vasomotor symptoms . These data corroborate the potential importance of soy supplementation in reducing chronic disease risk in Western population Background : Soy milk replacement in the diet might have beneficial effects on waist circumference and cardiovascular risk factors for overweight and obese subjects . Therefore , we are going to determine the effects of soy milk replacements on the waist circumference and cardiovascular risk factors among overweight and obese female adults . Methods : In this crossover r and omized clinical trail , 24 over weight and obese female adults were on a diet with soy milk or the diet with cow 's milk for four weeks . In the diet with soy milk only one glass of soy milk ( 240 cc ) was replaced instead of one glass of cow 's milk ( 240 cc ) . Measurements were done according to the st and ard protocol . Results : Waist circumference reduced significantly following soy milk period ( mean percent change in soy milk period for waist circumference : -3.79 ± 0.51 vs. -1.78 ± 0.55 % ; P = 0.02 in the cow 's milk period ) . Blood pressure , weight , liver enzymes and glycemic control indices did not changed significantly after soy milk period compared to the cow 's milk period . Conclusion : Among over weight and obese patients  , soy milk can play an important role in reducing waist circumference . However , soy milk replacement had no significant effects on weight , glycemic control indices , liver enzymes , fibrinogen and blood pressure in a short term trial BACKGROUND Soy drink replacement in the diet might have beneficial effects on anthropometric and blood pressure values for overweight and obese subjects . Therefore , we are going to determine the effects of soy drink replacements on the weight , waist circumference and blood pressure among overweight and obese female youths . PATIENTS AND METHODS This was a cross-over r and omized clinical trial on 23 overweight and obese female subjects . All patients were on a weight reducing diet . There were two trial periods for six weeks ( soy drink period and cow 's milk period ) and a washout period for 3 weeks . In the soy drink period only one glass of soy drink ( 240 cc ) was consumed instead of one glass of cow 's milk . RESULTS The mean age of the patients was 22±2 years . Mean of BMI was 28.1±0.5 .  Weight and waist circumference did not changed significantly after the soy drink period compared to the cow 's milk period . Systolic blood pressure reduced significantly following the soy drink period ( mean percent change in soy drink period : -4.0±0.9 vs -1.7±0.5 in the cow 's milk period ; p<0.05 ) . Diastolic blood pressure also reduced in the soy drink period ( -0.4±0.1 vs 0.4±0.1 ; p<0.05 ) . CONCLUSION Soy drink replacement could reduce both systolic and diastolic blood pressure among overweight and obese female youths . However , this replacement had no significant results on weight and waist circumference A high dietary intake of soy products ( eg , as in Japan and Singapore ) has been associated with a reduction in the incidence of breast cancer in premenopausal women . Phytoestrogens present in soybeans inhibit human breast cancer cell proliferation in vitro and breast cancer development in animal models , but no data exist on the effects of phytoestrogens on histologically normal human breasts . This study examines the effects of dietary soy supplementation on the proliferation rate of premenopausal , histologically normal breast epithelium and the expression of progesterone receptor .  Women ( n = 48 ) with benign or malignant breast disease were r and omly assigned to receive their normal diet either alone or with a 60-g soy supplement ( containing 45 mg isoflavones ) taken daily for 14 d. Biopsy sample s of normal breasts were labeled with [3H]thymidine to detect the number of cells in S phase and were immunocytochemically stained for the proliferation antigen Ki67 . The phytoestrogens genistein , daidzein , equol , enterolactone , and enterodiol were measured in serum sample s obtained before and after supplementation . Serum concentrations of the isoflavones genistein and daidzein increased in the soy group at 14 d. Results showed a strong correlation between Ki67 and the thymidine labeling index ( r = 0.868 , P < or = 0.001 ) . The proliferation rate of breast lobular epithelium significantly increased after 14 d of soy supplementation when both the day of menstrual cycle and the age of patient were accounted for . Progesterone receptor expression increased significantly in the soy group . Short-term dietary soy stimulates breast proliferation ; further studies are required to determine whether this is due to estrogen agonist activity and to examine the long-term effects of soy supplementation on the pituitary gl and and breast Although widely used , there is little information concerning the efficacy of corn-soy blend ( CSB ) supplementation in the treatment of moderate underweight in African children .  Lipid-based nutrient supplements ( LNS ) , which have proven to be beneficial treatment for severely wasted children , could offer benefits to less severely affected individuals . We conducted a clinical r and omized trial to determine whether LNS or CSB supplementation improves weight gain of moderately underweight children . A total of 182 underweight [ weight-for-age Z-score ( WAZ ) < -2 ] 6- to 15-mo-old children were r and omized to receive for 12 wk a ration of 43 g/d LNS or 71 g/d CSB , providing 1189 and 921 kJ , respectively , or no supplementation ( control ) . The primary outcome was weight change ; secondary outcomes included changes in anthropometric indices , hemoglobin levels , and morbidity . The body weight increases ( mean ± SD ) did not differ and were 620 ± 470 , 510 ± 350 , and 470 ± 350 g in the LNS , CSB , and control groups , respectively ( P = 0.11 ) . Compared with controls , infants and children in the LNS group gained more weight [ mean ( 95 % CI ) = 150 g ( 0 - 300 g ) ; P = 0.05 ] and had a greater increase in WAZ [ 0.33 ( -0.02 - 0.65 ) ; P = 0.04 ] . Weight and WAZ changes did not differ between the control and CSB groups . In exploratory stratified analysis , the weight increase was higher in the LNS group compared with the control group among those with lower initial WAZ [ 250 g ( 60 - 430 g ; P = 0.01 ] . Supplementation with LNS but not CSB modestly increases weight gain among moderately underweight children and the effect appears most pronounced among those with a lower initial WAZ Human clinical trials targeted at preventing gains in body weight using soy protein and isoflavones are limited to adults and yield conflicting results . We hypothesized that daily intake of soy protein/isoflavones would attenuate gains in body weight to a greater extent than a casein-based control in 18 to 19 year-old females . To test this hypothesis , we conducted a r and omized , double blind , placebo-controlled trial over 16 weeks to examine the effects of a soy protein/isoflavone-based meal replacement ( experimental group ) versus a casein-based meal replacement ( control group ) on body weight and body composition variables  in female college freshmen ( N = 120 ) .  Fat mass ( FM ) , fat-free soft tissue mass ( FFST ) , and percent body fat ( % BF ) were measured using dual energy X-ray absorptiometry ( DXA ; Delphi A ) . Repeated measures mixed models were used to determine the effects of treatment on anthropometric and body composition variables ( body weight , waist circumference , FM , FFST , and % BF ) . No significant group × time interactions were observed , even when body mass index was controlled for in the analysis . Over 16 weeks , body weight , FM , FFST , and % BF significantly increased in both groups ( P < .05 ) . Our findings show that female college freshmen  gained a significant amount of weight over the course of the 16-week study . Gains in body weight and FM were similar among participants assigned to the soy protein/isoflavone- and the casein-based meal replacements . Future research is warranted to determine the effects of soy protein/isoflavone- and casein-based meal replacements versus a non-intervention ( i.e. , non-protein based ) control Summary Objective This 12‐month r and omized , non‐inferiority clinical trial sought to determine the impact of consuming soy protein as part of an energy‐restricted , high‐protein diet on weight loss , body composition and cardiometabolic health . Methods Seventy‐one adults ( 58 female ) with overweight or obesity ( body mass index : 32.9 ± 3.6 kg m−2 ) were r and omly assigned to consume three servings of soy ( S ) or non‐soy ( NS ) protein foods per day for 12 months . All participants completed a group‐based behavioural weight loss program lasting 4 months ( M4 ) , and follow‐up assessment s were completed at month 12 ( M12 ) . Results Body weight was reduced in both groups at M4 ( S : −7.0 % ± 5.2 % , NS : −7.1 % ± 5.7 % ) and M12 ( S : 3.6 % ± 5.1 % , NS : −4.8 % ± 7.3 % ) . Body weight reductions ( mean difference [ 90 % confidence interval ] ) were not different between S and NS at either time point ( M4 : −0.16 % [ −1.4 , 3.6 ] , P = 0.90 ; M12 : 1.1 % [ −1.4 , 3.6 ] , P = 0.44 ) . Differences in body fat mass loss were not different between S and NS at M4 ( 0.29 ± 0.84 kg , P = 0.73 ) or M12 ( 0.78 ± 1.5 kg , P = 0.59 ) . Weight loss‐induced improvements in cholesterol , triglycerides and blood pressure did not differ between S and NS . Conclusion These results indicate that soy‐based protein foods can be effectively incorporated into an energy‐restricted , high‐protein diet for improving body weight , body composition and cardiometabolic health BACKGROUND We recently showed that calcitriol increases oxidative and inflammatory stress ; moreover , inhibition of calcitriol with high-calcium diets decreased both adipose tissue and systemic oxidative and inflammatory stress in obese mice , whereas dairy exerted a greater effect . However , these findings may be confounded by concomitant changes in adiposity . OBJECTIVE The objective of this study was to evaluate the acute effects of a dairy-rich diet on oxidative and inflammatory stress in overweight and obese subjects in the absence of adiposity changes . DESIGN Twenty subjects ( 10 obese , 10 overweight ) participated in a blinded , r and omized , crossover study of dairy- compared with soy-supplemented eucaloric diets . Two 28-d dietary periods were separated by a 28-d washout period . Inflammatory and oxidative stress biomarkers were measured on days 0 , 7 , and 28 of each dietary period . RESULTS The dairy-supplemented diet result ed in significant suppression of oxidative stress ( plasma malondialdehyde , 22 % ; 8-isoprostane-F(2alpha ) , 12 % ; P < 0.0005 ) and lower inflammatory markers ( tumor necrosis factor-alpha , 15 % , P < 0.002 ; interleukin-6 , 13 % , P < 0.01 ; monocyte chemoattractant protein-1 , 10 % , P < 0.0006 ) and increased adiponectin ( 20 % , P < 0.002 ) , whereas the soy exerted no significant effect . These effects were evident by day 7 of treatment and increased in magnitude at the end of the 28-d treatment periods . There were no significant differences in response to treatment between overweight and obese subjects for any variable studied . CONCLUSION An increase in dairy food intake produces significant and substantial suppression of the oxidative and inflammatory stress associated with overweight and obesity . This trial was registered at clinical trials.gov as NCT00686426 Isoflavones have been shown to improve glucose metabolism , but epidemiologic data are limited . We prospect ively investigated the relationship between soy product and isoflavone intake and the risk of developing type 2 diabetes among Japanese adults . Participants were 25,872 men and 33,919 women aged 45 - 75 y , who participated in the second survey of the Japan Public Health Center-Based Prospect i ve Study and had no history of diabetes .  Soy product and isoflavone intakes were ascertained using a 147-item FFQ . Odds ratios of self-reported , physician-diagnosed type 2 diabetes over 5 y were estimated using logistic regression analysis . A total of 1114 new cases of type 2 diabetes were self-reported . Intakes of soy products and isoflavones were not significantly associated with type 2 diabetes in either men or all women . However , among overweight women ( BMI > or = 25 kg/m(2 ) ) , a higher intake of soy products was associated with a lower risk of type 2 diabetes ; multivariable-adjusted odds ratios ( 95 % CI ) for the lowest through highest quintiles of soy product intake were 1.00 ( reference ) , 0.78 ( 0.52 - 1.18 ) , 0.79 ( 0.52 - 1.20 ) , 0.62 ( 0.39 - 0.99 ) , and 0.89 ( 0.55 - 1.44 ) , respectively , and we found a similar risk pattern for daidzein and genistein intakes . Overall , our results suggest that there are no benefits of soy product or isoflavone intake with respect to risk of type 2 diabetes in either men or women . The possible protective associations of soy and isoflavone intakes among overweight women deserves further investigation Background : Studies on soy supplementation suggest a cardioprotective potential . Objective : To examine the effects on LDL cholesterol and arterial function as a result of dietary enrichment with soy supplementation . Design : A R and omized , double blind , parallel intervention trial . Setting : Department of Endocrinology and Metabolism C , Aarhus University Hospital , and Department of Human Nutrition , The Royal Veterinary and Agricultural University , Denmark . Subjects : In all , 100 hypercholesterolaemic but otherwise healthy subjects were included in the study of which 89 completed it . Interventions : Subjects were r and omly assigned to 24 weeks of daily intake of either a soy supplement , Abalon ® ( 30 g soy protein , 9 g cotyledon fibre and 100 mg isoflavones ) or placebo ( 30 g of casein ) . The soy supplement and placebo were provided in two sachets daily that were stirred in water . Fasting plasma lipids , TNF-α , homocysteine , insulin sensitivity , homeostasis model assessment ( HOMA-IR ) , serum insulin , serum glucose , blood pressure as well as Glucagon-like peptide 1 ( GLP-1 ) , glucose-dependent insulinotropic peptide ( GIP ) and plasma lipids to a fat-rich meal were recorded before and after the intervention . In a sub study in 32 subjects , arterial dilatory capacity , compliance , and distensibility were recorded before and after the intervention . Results : In the main study , no difference in fasting plasma lipid levels or insulin sensitivity was found between soy-based supplement and placebo . A significant postpr and ial increase in GIP to the meal test was observed in the soy group ( P<0.05 ) . In a sub study , no difference between the groups in changes in flow-mediated vasodilatation ( P=0.84 ) was detected , while the soy supplementation caused a reduction in LDL and total cholesterol . Conclusions : No significant effects on blood lipids were observed in the main study to a soy supplementation in hypercholesterolaemic subjects after 24 weeks . In the sub study , the soy supplementation , however , reduced LDL and total cholesterol but did not influence markers of arterial function . Sponsorship : Nutri Pharma ASA , Oslo , Norway Soy consumption may be related to lower  breast cancer  risk as assessed by breast density . The aims of this 2-y trial were to examine the effects of soy foods and lifetime soy intake on mammographic density . After 220 premenopausal women were r and omly assigned to the intervention or control group , the former group consumed 2 daily servings of soy foods equivalent to 50 mg of isoflavones and the latter consumed their regular diet . The respective dropout rates were 15.6 and 12.6 % ; adherence to the study regimen was high . We assessed lifetime soy intake with a question naire and measured breast density in screening mammograms obtained at baseline and at the end of the trial for 98 intervention and 103 control women using a computer-assisted method . None of the mammographic outcomes differed significantly by experimental group . The total area of the breast increased and the size of the dense areas decreased significantly over time in both groups . After 2 y , the mean percentage density had decreased by 2.8 and 4.1 % in intervention and control women , respectively . Women who reported eating more soy during their lives had higher percentage densities than women whose diet included little soy ; this difference was significant only in Caucasians . Lower  soy  intake during early life and higher soy intake during adulthood predicted a greater reduction in the percentage density during the study period . After 2 y of intervention , we observed no significant differences in mammographic densities by intervention status , but it appears that soy consumption throughout life may have some effect on breast density OBJECTIVE To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause , compared with the effects of the hormone replacement therapy ( HRT ) . METHODS 187 healthy asymptomatic postmenopausal women , aged 39 - 60 , were recruited and r and omized into three groups : a soy rich diet group , a HRT group , and a control group .  Lipid profile , body mass index , blood pressure , endometrial thickness , uterine artery resistance index ( RI ) , were evaluated in all the participants at the baseline , after 6 months , and at the end of the study . RESULTS After a 6-month intervention period , the lipid profile in the soy rich diet group showed a favourable outcome , similar to that observed in the HRT group , but compliance to the diet was low . CONCLUSION Soy products may be used in the prevention of cardiovascular risk in postmenopausal women because of their efficacy in contrasting the negative effects of menopause on the cardiovascular system , but our findings should be confirmed ; moreover , suitable strategies to improve the compliance have to be considered Consumption of soy protein may reduce the risk of cardiovascular disease both through reduction in serum lipids and by the antioxidant properties of protein-associated soy isoflavones . However , the effect that processing required for the manufacture of breakfast cereals may have on the lipid lowering and antioxidant activities of soy has not been studied . We have therefore assessed the health benefits of soy incorporation into breakfast cereals . Twenty-five hyperlipidemic men and women took soy ( providing 36 g/d soy protein and 168 mg/d isoflavones ) and control breakfast cereals , each for 3 weeks in a r and omized crossover study with a 2-week washout period between treatments . Fasting blood sample s were obtained pretreatment and at weeks 2 and 3 of each treatment . No significant difference was seen in serum lipids between treatments at week 3 apart from a 3.8 % + /- 1.5 % higher apolipoprotein A-1 level on control versus soy ( P = .021 ) . However , oxidized low-density lipoprotein ( LDL ) was reduced on the test compared with the control both as total dienes in LDL and as the ratio of conjugated dienes to cholesterol in the LDL fraction by 9.2 % + /- 4.3 % ( P = .042 ) and 8.7 % + /- 4.2 % ( P = .050 ) , respectively . High isoflavone intakes in soy breakfast cereals may decrease the risk of cardiovascular disease by reducing oxidized LDL , while having no significant effect on the absolute concentration of LDL cholesterol
Analysis showed that soy products significantly reduced body weight , BMI , body fat percent and waist circumference in overweight or obese Asian population s ( −0.37 kg , P = 0.010 ; −0.27 kg/m2 , P = 0.042 ; −0.36 % , P = 0.032 ; −0.35 cm , P = 0.049 ) and more significant effects were observed in non-menopausal women reduced body weight ( −0.59 kg , P = 0.041 ) , BMI ( −0.59 , P = 0.041 ) and waist circumference ( −0.59 cm , P = 0.041 ) in overweight or obese population s. Conclusion : This meta- analysis showed that soy products  have weight loss effects , mainly due to soy protein , isoflavone and soy fiber
Background : The effect of soy products on the weight of overweight or obese people  is controversial , so we aim ed to conduct a systematic review and a meta- analysis of published r and omized controlled trials to analyze whether supplementation with soy products can help them to lose weight .