Effects of synbiotic on anthropometry, lipid profile and oxidative stress in obese children. Synbiotic Food Consumption Reduces Levels of Triacylglycerols and VLDL, but not Cholesterol, LDL, or HDL in Plasma from Pregnant Women Effects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high- and low-fat diets. The effects of synbiotic supplementation on insulin resistance/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: A randomized double blind placebo controlled clinical trial. Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults. Consumption of Synbiotic Bread Decreases Triacylglycerol and VLDL Levels While Increasing HDL Levels in Serum from Patients with Type-2 Diabetes The effects of probiotic and conventional yoghurt on lipid profile in women. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Effect of Probiotics on Lipid Profile, Glycemic Control, Insulin Action, Oxidative Stress, and Inflammatory Markers in Patients with Type 2 Diabetes: A Clinical Trial Effects of probiotic yogurt consumption on lipid profile in type 2 diabetic patients: A randomized controlled clinical trial Probiotic capsules do not lower plasma lipids in young women and men SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial Effect of synbiotic in constipated adult women - a randomized, double-blind, placebo-controlled study of clinical response. Effects of Synbiotic Food Consumption on Serum Minerals, Liver Enzymes, and Blood Pressure in Patients with Type 2 Diabetes: A Double-blind Randomized Cross-over Controlled Clinical Trial Effect of daily consumption of probiotic yoghurt on lipid profiles in pregnant women: a randomized controlled clinical trial Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
Recent studies have suggested some beneficial effects of probiotics and /or prebiotics on obesity in adults ; such experience is limited in children and adolescents . This study was an open-label , r and omised , controlled study including children with primary obesity . The first group was treated with a st and ard method with a reduced calorie intake and increased physical activity . The second group received add-on daily synbiotic supplementation during one month . The aim of this study was to evaluate potential effects of a synbiotic on anthropometric measurements , lipid profile and oxidative stress parameters . One month of supplementation of the synbiotic result ed in a significant reduction of weight ( P<0.001 ) and body mass index ( P<0.01 ) . Changes ( % reduction comparing to baseline ) in anthropometric measurements , were significantly higher in the children receiving the additional synbiotic supplement ( P<0.05 ) . The percentage of children with weight loss was higher in the synbiotic group , but not statistically significant ( 71.4 vs 64.2 % , P>0.05 ) . At the 30(th ) day of synbiotic intervention , serum total cholesterol , low density lipoprotein cholesterol and total oxidative stress levels significantly declined ( P<0.05 ) . Changes in serum lipid levels were significantly higher in the synbiotic group ( P<0.05 ) . Changes in serum total oxidative stress levels before and after the intervention period , were significant in synbiotic group ( P<0.01 ) . In our study , changes in weight , body mass index , and triceps skinfold thickness were higher in the group receiving the one month synbiotic supplement thin in the st and ard method group . The supplement tested also had a beneficial effect on lipid profile and total oxidative stress . To the best of our knowledge , this is the first study showing the effects of synbiotics on oxidative stress in obese patients with an additional effect on weight loss regarding to previous studies To our knowledge , no reports are available indicating the effects of synbiotic food consumption on blood lipid profiles and biomarkers of oxidative stress among pregnant women . This study was conducted to evaluate the effects of daily consumption of a synbiotic food on blood lipid profiles and biomarkers of oxidative stress in pregnant women . This r and omized , double-blind , controlled clinical trial was performed among 52 primigravida pregnant women , aged 18 to 35-year-old at their third trimester . After a 2-week run-in period , subjects were r and omly assigned to consume either a synbiotic ( n = 26 ) or control food ( n = 26 ) for 9 weeks . The synbiotic food consisted of a probiotic viable and heat-resistant Lactobacillus sporogenes ( 1 × 107 CFU ) and 0.04 g inulin (HPX)/g as the prebiotic . Patients were asked to consume the synbiotic and control foods two times a day . Biochemical measurements including blood lipid profiles , plasma total antioxidant capacity ( TAC ) and total glutathione ( GSH ) were conducted before and after 9 weeks of intervention . Consumption of a synbiotic food for 9 weeks result ed in a significant reduction in serum TAG ( P = 0.04 ) , VLDL ( P = 0.04 ) and a significant rise in plasma GSH levels ( P = 0.004 ) compared to the control food . No significant effects of the synbiotic food consumption on serum TC , LDL , HDL and plasma TAC levels ( P > 0.05 ) were observed . Trial registry code : http://www.i rct .ir . I RCT 201212105623N3 The aim of this study was to evaluate the effect of a synbiotic containing Lactobacillus acidophilus ATCC 4962 , fructooligosaccharide , inulin and mannitol on plasma lipid profiles and erythrocyte membrane properties in hypercholesterolaemic pigs on high- and low-fat diets . Twenty-four white male L and race pigs were r and omly allocated to four treatment groups for 8 weeks ( n 6 ) . Treatment factors were the supplementation of synbiotic ( with and without ) and dietary fat ( 5 and 15 % ) . The supplementation of synbiotic reduced plasma total cholesterol ( P = 0.001 ) , TAG ( P = 0.002 ) and LDL-cholesterol ( P = 0.045 ) for both dietary fats . A higher concentration of esterified-cholesterol in HDL of pigs supplemented with synbiotic than the control regardless of dietary fat ( P = 0.036 ) indicated that cholesterol was reduced in the form of cholesteryl esters . Reduced concentration of cholesteryl esters ( P < 0.001 ) and increased concentration of TAG ( P = 0.042 ) in LDL of pigs on synbiotic suggested that LDL-cholesterol was reduced via the hydrolysis of smaller and denser LDL particles . The erythrocytes of pigs without any synbiotic showed more prevalence of spur cells than those given the synbiotic , as supported by the higher cholesterol : phospholipid ratio in erythrocytes ( P = 0.001 ) . Also , membrane fluidity and rigidity were improved as supported by the decreased fluorescence anisotropies in the Hb-free erythrocyte membrane of pigs given synbiotic ( P < 0.001 ) . The administration of the synbiotic reduced plasma TAG , total cholesterol and LDL-cholesterol in hypercholesterolaemic pigs , possibly in the form of cholesteryl esters , via the interrelated pathways of lipid transporters ( VLDL , LDL and HDL ) . The synbiotic also reduced deformation of erythrocytes via improved membrane fluidity and permeability AIMS The role of gut microbiota in the management of diabetes is shown . In this r and omized clinical trial we assessed the effects of synbiotic supplementation on insulin , lipid profile and antioxidative status among women with gestational diabetes mellitus ( GDM ) . METHODS Ninety pregnant women with GDM were r and omly assigned into two groups to receive either a daily synbiotic capsule - consisting of L. acidophilus , L. plantarum , L. fermentum , L. gasseri ( 1.5 - 7.0 × 109 - 10 CFU/g ) - with fructooligosaccharide ( 38.5 mg ) , or placebo for 6 weeks . Fasting plasma glucose ( FPG ) , insulin , homeostasis model assessment -insulin resistance ( HOMA-IR ) , quantitative insulin sensitivity check index ( QUICKI ) , high- and low density lipoprotein cholesterol ( HDL-C , LDL-C ) , total cholesterol ( TC ) , triglycerides ( TG ) , total antioxidant capacity ( TAC ) , and systolic and diastolic blood pressure ( SBP , DSP ) were assessed before and after the intervention . RESULTS No significant changes in FPG , insulin resistance/sensitivity , lipid profile and TAC indices were seen in synbiotic group compared to the placebo one ( p > 0.05 ) . Significant within group increases for HDL-C and TAC levels in synbiotic group were observed ( p < 0.05 ) . LDL-C showed significant increment in the placebo group compared to the baseline of the study ( 6.9 mg/dL , p < 0.05 ) . Between group comparison showed significant decrease in SBP and DBP in synbiotic group compared to placebo ( -2.5 vs. 8.6 mmHg , and -1.8 vs. 2.1 mmHg , p < 0.05 ) . CONCLUSIONS The results showed that , in women with GDM , synbiotic supplementation had no effect on FPG and insulin resistance/sensitivity indices . Lipid profile and TAC status may be affected by synbiotic supplementation . Synbiotic is effective in reducing of blood pressure in women with GDM AIM To investigate the effect of three weeks ' intervention with a probiotic Lactobacillus rhamnosus GG ( LGG ) bacteria on global serum lipidomic profiles and evaluate whether the changes in inflammatory variables ( CRP , TNF-alpha and IL-6 ) are reflected in the global lipidomic profiles of healthy adults . METHODS We performed UPLC/MS-based global lipidomic platform analysis of serum sample s ( n = 26 ) in a sub study of a r and omised , double-blind , placebo-controlled 3-wk clinical intervention trial investigating the immunomodulatory effects of probiotics in healthy adults . RESULTS A total of 407 lipids were identified , corresponding to 13 different lipid classes . Serum sample s showed decreases in the levels of lysophosphatidylcholines ( LysoGPCho ) , sphingomyelins ( SM ) and several glycerophosphatidylcholines ( GPCho ) , while triacylglycerols ( TAG ) were mainly increased in the probiotic LGG group during the intervention . Among the inflammatory variables , IL-6 was moderately associated by changes in global lipidomic profiles , with the top-ranked lipid associated with IL-6 being the proinflammatory LysoGPCho ( 20:4 ) . There was a weak association between the lipidomic profiles and the two other inflammatory markers , TNF-alpha and CRP . CONCLUSION This was the first study to investigate the effects of probiotic intervention on global lipidomic profiles  in humans . There are indications that probiotic LGG intervention may lead to changes in serum global lipid profiles , as reflected in decreased GPCho , LysoGPCho and SM as well as mainly increased TAG To our knowledge , no reports are available indicating the favorable effects of synbiotic bread consumption on blood lipid profiles among patients with type 2 diabetes mellitus ( T2DM ) . This study was conducted to evaluate the effects of the daily consumption of synbiotic bread on blood lipid profiles of patients with T2DM . This r and omized double-blinded controlled clinical trial was performed with 78 diabetic patients , aged 35–70 years . After a 2-week run-in period , subjects were r and omly assigned to consume either synbiotic ( n = 26 ) , probiotic ( n = 26 ) or control bread ( n = 26 ) for 8 weeks . The synbiotic bread contained viable and heat-resistant probiotic Lactobacillus sporogenes ( 1 × 108 CFU ) and 0.07 g inulin ( HPX ) as prebiotic per 1 g. The probiotic bread contained L. sporogenes ( 1 × 108 CFU ) per 1 g. Patients were asked to consume the synbiotic , probiotic and control breads three times a day in a 40 g package for a total of 120 g/day . Biochemical measurements including blood lipid profiles were conducted before and after 8 weeks of intervention . Consumption of the synbiotic bread , compared to the probiotic and control breads , led to a significant decrease in serum TAG ( P = 0.005 ) , VLDL-C ( P = 0.005 ) , TC/HDL-C ( P = 0.002 ) and a significant increase in serum HDL-C levels ( P = 0.01 ) . No significant effect of synbiotic bread consumption on FPG , TC , LDL-C and non-HDL-C levels was seen compared to the probiotic and control breads ( P > 0.05 ) . Trial registry code : http://www.i rct .ir I RCT 201311215623N13 Many studies have been done on the hypocholesterolaemic effect of probiotic yoghurt . The results , however , are not conclusive . The aim of the present study was to test the effect of probiotic and conventional yoghurt on the lipid profile in women . In a r and omised trial , ninety female volunteers aged 19 - 49 years were assigned to three groups . Subjects consumed daily 300 g probiotic yoghurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or 300 g conventional yoghurt or no yoghurt for 6 weeks . Fasting blood sample s , 3 d dietary records and anthropometric measurements were collected at baseline ( T1 ) , end of week 3 ( T2 ) and end of week 6 ( T3 ) . Lipid profile parameters were determined by enzymic methods . Results showed no significant difference in lipid profile within any group throughout the study . Comparing mean differences ( T1 - T3 ) among the three groups showed : no difference in TAG and LDL-cholesterol , a decrease in cholesterol in both conventional ( P < 0.05 ) and probiotic yoghurt groups ( P < 0.005 ) compared with the control group , a decrease in total : HDL-cholesterol ratio for conventional ( P < 0.05 ) and probiotic yoghurt groups ( P < 0.001 ) compared with the control group , and an increase in HDL-cholesterol in the probiotic yoghurt group ( P < 0.05 ) compared with the control group . Positive changes in lipid profile were observed in both yoghurt groups . Any added effect , therefore , is due to the consumption of fermented milk products BACKGROUND Animal studies suggest that prebiotics and probiotics exert protective effects against tumor development in the colon , but human data supporting this suggestion are weak . OBJECTIVE The objective was to verify whether the prebiotic concept ( selective interaction with colonic flora of nondigested carbohydrates ) as induced by a synbiotic preparation-oligofructose-enriched inulin ( SYN1 ) + Lactobacillus rhamnosus GG ( LGG ) and Bifidobacterium lactis Bb12 (BB12)-is able to reduce the risk of colon cancer in humans . DESIGN The 12-wk r and omized , double-blind , placebo-controlled trial of a synbiotic food composed of the prebiotic SYN1 and probiotics LGG and BB12 was conducted in 37 colon cancer patients and 43 polypectomized patients . Fecal and blood sample s were obtained before , during , and after the intervention , and colorectal biopsy sample s were obtained before and after the intervention . The effect of synbiotic consumption on a battery of intermediate bio-markers for colon cancer was examined . RESULTS Synbiotic intervention result ed in significant changes in fecal flora : Bifidobacterium and Lactobacillus increased and Clostridium perfringens decreased . The intervention significantly reduced colorectal proliferation and the capacity of fecal water to induce necrosis in colonic cells and improve epithelial barrier function in polypectomized patients . Genotoxicity assays of colonic biopsy sample s indicated a decreased exposure to genotoxins in polypectomized patients at the end of the intervention period . Synbiotic consumption prevented an increased secretion of interleukin 2 by peripheral blood mononuclear cells in the polypectomized patients and increased the production of interferon gamma in the cancer patients . CONCLUSIONS Several colorectal cancer biomarkers can be altered favorably by synbiotic intervention Background : The dramatic increase in the incidence of diabetes and its associated complications require a natural and safe solution to control and delay such complications . The present study tested the hypothesis that probiotics may affect biochemical indices of diabetic patients Methods : Thirty four types 2 diabetic patients aged between 25 to 65 years , and diagnosed with diabetes for less than 15 years were selected for this single- blinded clinical trial . Using balanced block r and om sampling , the patients were divided into two groups of intervention ( probiotics ) and placebo . Blood sample s tested for baseline glucose , insulin , TG , total cholesterol , LDL-C , HDL-C , malondialdehyde , high sensitive CRP ( hs-CRP ) and IL-6 . After six weeks of experiment , fasting blood sample s were re-tested and the data obtained were analyzed using SPSS software . Results : There were no significant differences between anthropometric data including body mass index and waist to hip ratio in placebo and treatment groups . There was no significant difference in FBS , Serum TG concentration total cholesterol and LDL-C levels between placebo and treatment groups . HDL-C levels were slightly elevated after probiotic treatment , which were not statistically significant . Insulin , MDA and IL-6 levels were reduced and high sensitive CRP hs . CRP levels were elevated , although , not statistically significant . Conclusion : The result of this study indicates a non- significant declining trend in the level of TG , MDA and IL-6 and insulin resistance after consumption of probiotics Background : Alteration in plasma lipid and lipoprotein profile has been documented in diabetic patients . The purpose of this study was to compare the effect of probiotic and conventional yogurt on lipid profile in type 2 diabetes mellitus patients . Material s and Methods : A total of 44 patients with type 2 diabetes aged 30 - 60 years old who had low density lipoprotein cholesterol ( LDL-c ) ≥100 mg/dl enrolled in this r and omized , double – blind controlled trial and were assigned to two intervention and control groups . The subjects in the intervention group consumed 300 g/d probiotic yogurt containing Lactobacillus acidophilus La-5 and Bifidobacterium lactis Bb-12 and subjects in the control group consumed 300 g/d conventional yogurt for 8 weeks . Anthropometric indices , dietary intake , and serum lipid profile were evaluated at the beginning and end of the intervention . Independent- sample t-test , paired sample t-test , ANCOVA , and repeated measures were used for statistical analysis . Results : The consumption of probiotic yogurt caused significant decrease in LDL-c/high density lipoprotein cholesterol ( HDL-c ) ratio ( 3.13 ± 1.00 - 2.07 ± 0.71 , P = 0.016 ) . The levels of HDL-c were increased significantly ( 43.66 ± 6.80 - 50.42 ± 6.64 , P = 0.023 ) in the intervention group postintervention . However , there were no significant differences in triglyceride and total cholesterol levels between two groups postintervention ( P < 0.05 ) . Conclusion : It is suggested that probiotic yogurt consumption may be used as an alternative prevention approach and treatment method to improve dyslipidemia in patients with type 2 diabetes Objective : To investigate the effect of probiotic capsules on plasma lipids . Design : A r and omized , single-blinded , placebo-controlled , parallel-arm trial . Subjects : Fifty-five normocholesterolemic subjects ages 18–36 ( 33 premenopausal women and 22 men).Intervention : Each subject consumed either three probiotic capsules each containing a total of 109 colony-forming units Lactobacillus acidophilus and Bifidobacterium longum and 10–15 mg fructo-oligosaccharide or three placebo capsules daily for 2 months ( men ) or two menstrual cycles ( women ) . Plasma lipids were measured before and following the intervention ( during the early follicular phase for women ) . Results : Plasma concentrations of total cholesterol , high-density lipoprotein cholesterol , low-density lipoprotein cholesterol and triglyceride were not altered by consumption of probiotic or placebo capsules and were not different between treatment groups following the intervention . Conclusions : These results do not support a beneficial effect of Lactobacillus acidophilus strain DDS-1 and Bifidobacterium longum strain UABL-14 on plasma lipids in normocholesterolemic young women and men . Sponsorship : Supported by the Minnesota Agricultural Experiment Station and UAS Laboratories Background Emerging evidence suggests modulating the microbiota in the large bowel of patients with chronic kidney disease ( CKD ) through pre- and /probiotic supplementation may inhibit the development of key nephrovascular toxins . To date , quality intervention trials investigating this novel treatment in CKD are lacking . The aim of SYNERGY is to assess the effectiveness of synbiotics ( co-administration of pre- and probiotics ) as a potential treatment targeting the synthesis of uremic toxins , specifically , indoxyl sulphate ( IS ) and p-cresyl sulphate ( PCS ) . Methods / design Thirty-seven patients with moderate to severe CKD ( Stage IV and V , pre-dialysis ) will be recruited to a double-blind , placebo-controlled , r and omised cross-over trial . Patients will be provided with synbiotic therapy or placebo for 6 weeks , with a 4 week washout before cross-over . The primary outcome is serum IS , total and free ( unbound ) concentrations , measured using ultra-performance liquid chromatography . Secondary outcomes include serum PCS , total and free ( unbound ) concentrations ; cardiovascular risk , measured by serum lipopolysaccharides , serum trimethylamine-N-oxide ( TMAO ) and inflammation and oxidative stress markers ; kidney damage , measured by 24 hour proteinuria and albuminuria , estimated glomerular filtration rate and renal tubule damage ( urinary kidney injury molecule-1 ) ; patients ’ self assessed quality of life ; and gastrointestinal symptoms . In addition , the effects on the community structure of the stool microbiota will be explored in a subset of patients to vali date the mechanistic rationale underpinning the synbiotic therapy . Discussion IS and PCS are two novel uremic toxins implicated in both cardiovascular disease ( CVD ) and progression of CKD . Preliminary studies indicate that synbiotic therapy maybe a promising strategy when considering a targeted , tolerable and cost-efficient therapy for lowering serum IS and PCS concentrations . This trial will provide high quality ‘ proof-of-concept ’ data to eluci date both the efficacy of synbiotic therapy for lowering the toxins and whether reductions in serum IS and PCS translate into clinical benefits . Considering the potential of pre- and probiotics to not only shift toxin levels , but to also impede CVD and CKD progression , SYNERGY will provide vital insight into the effectiveness of this innocuous nutritional therapy . Trial Registration Universal Trial Number : U1111 - 1142 - 4363 . Australian New Zeal and Clinical Trials Registry Number : ACTRN12613000493741 , date registered : 2nd May 2013 BACKGROUND & AIMS Synbiotic intake may selectively change microbiota composition , restore microbial balance in the gut and improve gastrointestinal functions . We have assessed the clinical response of chronically constipated women to a commercially available synbiotic , combining fructooligosaccharides with Lactobacillus and Bifidobacterium strains ( LACTOFOS ® ) . METHODS Following 1 week of non-interventional clinical observation , 100 constipated adult women , diagnosed by ROME III criteria , were r and omized to receive two daily doses ( 6 g ) of synbiotic or maltodextrin ( placebo group ) , for 30 days . Treatment response was evaluated by patient 's daily record of evacuation ( stool frequency , consistency and shape , according to Bristol scale ) , abdominal symptoms ( abdominal pain , bloating and flatulence ) and constipation intensity ( Constipation Scoring System AGACHAN ) . RESULTS Patients treated with synbiotic had increased frequency of evacuation , as well as stool consistency and shape nearer normal parameters than the placebo group , with significant benefits starting during the second and third weeks , respectively ( interaction group/time , P<0.0001 ) . There were no significant differences in abdominal symptoms , but AGACHAN score was better in the synbiotic than in the placebo group . CONCLUSIONS Dietary supplementation with a synbiotic composed of fructooligosaccharides with Lactobacillus and Bifidobacterium improved evacuation parameters and constipation intensity of chronically constipated women , without influencing abdominal symptoms Background : This research was to examine the effects of synbiotic intake on minerals , liver enzymes , and blood pressure in patients with type 2 diabetes ( T2D ) . Methods : This r and omized , cross-over clinical trial was performed among 62 diabetic patients . Persons were r and omly assigned to intake either a synbiotic ( n = 62 ) or a control food ( n = 62 ) for 6 weeks . A 3-week washout period was applied following which persons were crossed over to the alternate intervention arm for an additional 6 weeks . The synbiotic was consisted of Lactobacillus sporogenes ( 1 × 107 CFU ) , 0.04 g inulin ( HPX ) as prebiotic . Persons were asked to consume the synbiotic and control foods 27 g a day . Blood pressure was measured , and blood sample s were taken at baseline and after 6-week intervention to assess calcium , magnesium , iron , alkaline phosphatase , aspartate aminotransferase , alanine aminotransferase , and total bilirubin . Results : The consumption of a synbiotic food , compared to the control food , result ed in a significant rise of calcium ( 0.66 vs. −0.14 mg/dL , P = 0.03 ) and iron ( 5.06 vs. −9.98 mg/dL , P = 0.03 ) . The decrease of total bilirubin ( 0.08 vs. −0.04 mg/dL ; P = 0.009 ) was also seen in the synbiotic group compared with the control group . Conclusions : Overall , synbiotic in T2D patients had beneficial effects on calcium , iron , and total bilirubin concentrations Background : Due to enhanced fat storage primarily during the mid-pregnancy period , pregnancy is associated with elevated levels of lipid profiles . To our knowledge , no reports are available indicating the effects of probiotic yoghurt consumption on serum lipid profiles in pregnant women . Objective : This study was design ed to determine the effects of daily consumption of probiotic yoghurt on lipid profiles of Iranian pregnant women . Methods : This r and omized single-blinded controlled clinical trial was performed among 70 pregnant women , primigravida , aged 18–30 years old who were carrying singleton pregnancy at their third trimester . Subjects were r and omly assigned to consume 200 g/d of conventional ( n = 33 ) or the probiotic group ( n = 37 ) for 9 weeks . The probiotic yoghurt was a commercially available product prepared with the starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus , enriched with probiotic culture of two strains of lactobacilli ( Lactobacillus acidophilus LA5 ) and bifidobacteria ( Bifidobacterium animalis BB12 ) with a total of min 1 × 107 colony-forming units . The conventional yoghurt contained the starter cultures of S. thermophilus and L. bulgaricus . Fasting blood sample s were taken at baseline and after 9-weeks intervention to measure serum lipid profiles . Results : Although consumption of probiotic yogurt for 9 weeks had been result ed in a significant reduction in serum total- ( −53.7 mg/dL , p = 0.001 ) , LDL- ( −35.2 mg/dL , p = 0.006 ) and HDL-cholesterol levels ( −9.8 mg/dL , p = 0.002 ) as well as serum triglyceride concentrations ( −42.8 mg/dL , p = 0.029 ) , no significant differences were found comparing probiotic and conventional yogurts in terms of their effect on serum lipid profiles . Within-Group differences in conventional yogurt group revealed a significant reduction in HDL-cholesterol levels ( −8.4 mg/dL , p = 0.005 ) and borderline significant reduction in serum total cholesterol concentrations ( −21.6 mg/dL , p = 0.08 ) . Conclusion : In conclusion , consumption of probiotic yogurt among pregnant women could not affect serum lipid profiles as compared to the conventional yogurt The purpose of this study was to investigate the effects of probiotic and conventional yogurt on the lipid profile in type 2 diabetic people . In a r and omized double-blind controlled trial , 60 people ( 23 males and 37 females ) with type 2 diabetes and low-density lipoprotein cholesterol ( LDL-C ) greater than 2.6 mmol/L were assigned to 2 groups . Participants consumed daily 300 g of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or 300 g of conventional yogurt for 6 wk . Fasting blood sample s , anthropometric measurements and 3-d , 24-h dietary recalls were collected at the baseline and at the end of the trial . Probiotic yogurt consumption caused a 4.54 % decrease in total cholesterol and a 7.45 % decrease in LDL-C compared with the control group . No significant changes from baseline were shown in triglyceride and high-density lipoprotein cholesterol ( HDL-C ) in the probiotic group . The total cholesterol : HDL-C ratio and LDL-C : HDL-C ratio as atherogenic indices significantly decreased in the probiotic group compared with the control group . Probiotic yogurt improved total cholesterol and LDL-C concentrations in type 2 diabetic people and may contribute to the improvement of cardiovascular disease risk factors Background To our knowledge , no reports are available indicating the effects of synbiotic supplementation on hormonal status , biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome ( PCOS ) . This research was done to assess the effects of synbiotic supplementation on hormonal status , biomarkers of inflammation and oxidative stress in subjects with PCOS . Methods This r and omized double-blind , placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria . Subjects were r and omly assigned into two groups to take either synbiotic ( n = 30 ) or placebo ( n = 30 ) for 12 weeks . Endocrine , inflammation and oxidative stress biomarkers were quantified at baseline and after the 12-week intervention . Results After the 12-week intervention , compared with the placebo , synbiotic supplementation significantly increased serum sex hormone-binding globulin ( SHBG ) ( changes from baseline in synbiotic group : + 19.8 ± 47.3 vs. in placebo group : + 0.5 ± 5.4 nmol/L , p = 0.01 ) , plasma nitric oxide ( NO ) ( changes from baseline in synbiotic group : + 5.5 ± 4.8 vs. in placebo group : + 0.3 ± 9.1 μmol/L , p = 0.006 ) , and decreased modified Ferriman Gallwey ( mF-G ) scores ( changes from baseline in synbiotic group : − 1.3 ± 2.5 vs. in placebo group : − 0.1 ± 0.5 , p = 0.01 ) and serum high-sensitivity C-reactive protein ( hs-CRP ) ( changes from baseline in synbiotic group : − 950.0 ± 2246.6 vs. in placebo group : + 335.3 ± 2466.9 ng/mL , p = 0.02 ) . We did not observe any significant effect of synbiotic supplementation on other hormonal status and biomarkers of oxidative stress . Conclusions Overall , synbiotic supplementation for 12 weeks in PCOS women had beneficial effects on SHBG , mFG scores , hs-CRP and NO levels , but did not affect other hormonal status and biomarkers of oxidative stress . Trial registration This study was retrospectively registered in the Iranian website ( www.i rct .ir ) for registration of clinical trials ( I RCT 201509115623N53 ) , on 2015–09 - 27
The effects are more pronounced when synbiotics supplements are consumed for > 8 weeks .
Synbiotic supplements may be beneficial to improve lipid profile , especially when they are consumed for > 8 weeks
Existing evidence on the possible effects of synbiotics on lipid profile is inconclusive .
The aim of the present systematic review was to clarify the effects of synbiotics consumption on lipid profile .