Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Medium- versus long-chain triglycerides for 27 days increases fat oxidation and energy expenditure without resulting in changes in body composition in overweight women Greater rise in fat oxidation with medium-chain triglyceride consumption relative to long-chain triglyceride is associated with lower initial body weight and greater loss of subcutaneous adipose tissue Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. Dietary medium-chain triacylglycerols suppress accumulation of body fat in a double-blind, controlled trial in healthy men and women. A good response to oil with medium- and long-chain fatty acids in body fat and blood lipid profiles of male hypertriglyceridemic subjects. Medium- and Long-Chain Triacylglycerols Reduce Body Fat and Blood Triacylglycerols in Hypertriacylglycerolemic, Overweight but not Obese, Chinese Individuals Effects of margarine containing medium-chain triacylglycerols on body fat reduction in humans. Value of VLCD supplementation with medium chain triglycerides Medium-chain fatty acids: evidence for incorporation into chylomicron triglycerides in humans. The effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight Lipid infusion with different triglyceride cores (long-chain vs medium-chain/long-chain triglycerides): effect on plasma lipids and bilirubin binding in premature infants. Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans. Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects Randomized clinical trial of new intravenous lipid (SMOFlipid 20%) versus medium-chain triglycerides/long-chain triglycerides in adult patients undergoing gastrointestinal surgery.
OBJECTIVE The objectives of this study were to compare the effects of diets rich in medium-chain triglycerides ( MCTs ) or long-chain triglycerides ( LCTs ) on body composition , energy expenditure , substrate oxidation , subjective appetite , and ad libitum energy intake in overweight men . RESEARCH METHODS AND PROCEDURES Twenty-four healthy , overweight men with body mass indexes between 25 and 31 kg/m(2 ) consumed diets rich in MCT or LCT for 28 days each in a crossover r and omized controlled trial . At baseline and after 4 weeks of each dietary intervention , energy expenditure was measured using indirect calorimetry , and body composition was analyzed using magnetic resonance imaging . RESULTS Upper body adipose tissue ( AT ) decreased to a greater extent ( p < 0.05 ) with functional oil ( FctO ) compared with olive oil ( OL ) consumption ( -0.67 + /- 0.26 kg and -0.02 + /- 0.19 kg , respectively ) . There was a trend toward greater loss of whole-body subcutaneous AT volume ( p = 0.087 ) with FctO compared with OL consumption . Average energy expenditure was 0.04 + /- 0.02 kcal/min greater ( p < 0.05 ) on day 2 and 0.03 + /- 0.02 kcal/min ( not significant ) on day 28 with FctO compared with OL consumption . Similarly , average fat oxidation was greater ( p = 0.052 ) with FctO compared with OL intake on day 2 but not day 28 . DISCUSSION Consumption of a diet rich in MCTs results in greater loss of AT compared with LCTs , perhaps due to increased energy expenditure and fat oxidation observed with MCT intake . Thus , MCTs may be considered as agents that aid in the prevention of obesity or potentially stimulate weight loss Prior studies of medium-chain triglyceride ( MCT ) suggest that MCT might be a useful tool for body fat mass management in obese nondiabetic humans . We now report a pilot study that tests if MCT is beneficial for moderately overweight subjects with type 2 diabetes mellitus . The study was conducted in a group of 40 free-living subjects in an urban area of China . The subjects were r and omized into 2 test groups , with one given MCT and the other corn oil as control for long-chain triglycerides ( LCTs ) . The test oil ( 18 g/d ) was administered as part of daily food intake for 90 days . All subjects completed the study with self-reported full compliance . Body weight , waist circumference ( WC ) , and serum sample s were analyzed on days 0 , 45 , and 90 . The MCT group showed an across-time reduction in body weight and WC , an increase in serum C-peptide concentration , a reduction in homeostasis model assessment of insulin resistance , and a decrease in serum cholesterol concentration ( P < .05 , repeated measures ) . No significant across-time difference for the above parameters was detected for the LCT group . These changes were associated with an involuntary reduction in energy intake in the MCT group ( P < .05 , repeated measures ) . A between-group comparison also shows reduced body weight , WC , and homeostasis model assessment of insulin resistance in the MCT group compared with the LCT group at the end of the study . Collectively , our results suggest a link between moderate consumption of MCT and improved risk factors in moderately overweight humans in a low-cost , free-living setting OBJECTIVE : To determine the effects of long-term consumption of medium chain ( MCT ) versus long chain triglycerides ( LCT ) on energy expenditure ( EE ) , substrate oxidation and body composition . HYPOTHESIS : MCT consumption will not result in greater EE , substrate oxidation , and body weight loss compared with LCT consumption . RESEARCH METHODS AND PROCEDURES : Seventeen healthy obese women participated in this r and omized , crossover inpatient trial . Meals were prepared and consumed on site for two periods of 27 days . Diets containing 40 % of energy as fat , with treatment fat comprising 75 % of the total fat , were design ed to supply each subject with their individual weight-maintaining energy needs . The MCT diet contained 67 % of treatment fat as MCT oil ( 49 % octanoate , 50 % decanoate ) whereas the LCT diet contained exclusively beef tallow as treatment fat . Body composition was assessed by magnetic resonance imaging ( MRI ) on day 1 and 28 of each phase while energy expenditure was measured on day 2 and 27 . RESULTS : Changes in total and subcutaneous adipose tissue volumes following consumption of MCT and LCT were not different ( −0.61±0.38 l vs −0.54±0.48 l and −0.58±0.35 l vs −0.48±0.40 l , respectively ) . Average EE and fat oxidation were greater ( P<0.05 ) during MCT than LCT consumption ( 0.95±0.019 vs 0.90±0.024 kcal/min , respectively , for EE and 0.080±0.0026 vs 0.075±0.0022 g/min , respectively for fat oxidation ) . DISCUSSION : These results show that long-term consumption of MCT  enhances EE and fat oxidation in obese women , when compared to LCT consumption . The difference in body composition change  between MCT and LCT consumption , although not statistically different , was consistent with differences predicted by the shifts in EE . It can be concluded that substitution of MCT for LCT in a targeted energy balance diet may prevent long-term weight gain via increased EE OBJECTIVE : Medium-chain triglyceride ( MCT ) consumption has been shown to increase energy expenditure ( EE ) and lead to greater losses of the adipose tissue in animals and humans . The objective of this research was to examine the relationship between body composition and thermogenic responsiveness to MCT treatment . DESIGN : R and omized , crossover , controlled feeding trial , with diets rich in either MCT or long-chain triglyceride ( LCT ) ( as olive oil ) for periods of 4 weeks each . SUBJECTS : A total of 19 healthy overweight men aged ( x±s.e.m . ) 44.5±2.5 y with a body mass index of 27.8±0.5 kg/m2 . MEASUREMENTS : EE and body composition were measured using indirect calorimetry and magnetic resonance imaging , respectively , at the baseline and end point of each feeding period . EE was measured for 30 min before consumption of a st and ard meal and for 5.5 h following the meal . RESULTS : Body weight ( BW ) decreased ( P<0.05 ) by 1.03±0.25 kg with MCT consumption compared to 0.62±0.29 kg with LCT consumption . The difference in average EE  between MCT and LCT consumptions was related to initial BW , such that men with lower initial BW had a greater rise in EE  with MCT consumption relative to LCT on day 28 ( r=−0.472 , P=0.04 ) but not day 2 ( r=−0.368 , P=0.12 ) . Similar results were obtained with fat oxidation on day 28 ( r=−0.553 , P=0.01 ) . The greater rise in fat oxidation  with MCT compared to LCT consumption on day 2 tended to be related to greater loss of BW  after MCT vs LCT consumption ( r=−0.4075 , P=0.08 ) . CONCLUSION : These data suggest that shunting of dietary fat towards oxidation results in diminished fat storage , as reflected by the loss of BW and subcutaneous adipose tissue . Furthermore , MCT consumption may stimulate EE and fat oxidation to a lower extent in men of greater BW compared to men of lower BW , indicative of the lower responsiveness to a rapidly oxidized fat by overweight men Although medium chain triglyceride ( MCT ) is less calorically dense than long chain triglyceride ( LCT ) , it produces a greater thermic effect following ingestion . We hypothesized that the previously observed high rate of thermogenesis produced by MCT overfeeding was due to hepatic de novo synthesis of long chain fatty acids ( LCFA ) from the excess medium chain fatty acids ( MCFA ) . To study this , we compared the effects of overfeeding MCT- and LCT-containing diets on blood lipid profiles .  Ten in-patient , nonobese males were overfed ( 150 % of estimated energy requirements ) two formula diets for 6 days each , in a r and omized crossover design . Diets differed only in the composition of the fat and contained either 40 % of energy as MCT or LCT ( soybean oil ) . The major differences between diets in the result ing pattern of blood lipids were : 1 ) a reduction in fasting serum total cholesterol concentrations with the LCT , but not the MCT diet ; and 2 ) a threefold increase in fasting serum triglyceride concentrations with MCT , but not LCT , diet . Moreover , 10 % of the fasting triglyceride fatty acids were medium chain and 40 % were 16:0 with the MCT diet . This compared to 1 % and 20 % for medium chain and 16:0 , respectively , with the LCT diet . In addition , there were increases in 16:1 , 18:0 , and 18:1 in the triglycerides during MCT feeding . The changes in fatty acids in triglycerides with MCT feeding are consistent with the hypothesis that excess dietary MCT cause a significant increase in the hepatic synthesis of these fatty acids from MCFA through de novo synthesis and /or chain elongation and desaturation . These processes could account for the higher rate of postpr and ial thermogenesis with MCT as compared to LCT We investigated the effect of long-term ingestion of dietary medium-chain triacylglycerols ( MCT ) on body weight and fat in humans . Using a double-blind , controlled protocol , we assessed the potential health benefits of MCT compared with long-chain triacylglycerols ( LCT ) in 78 healthy men and women [ body mass index ( BMI ) > or = 23 kg/m(2 ) : n = 26 ( MCT ) , n = 30 ( LCT ) ; BMI < 23 kg/m(2 ) : n = 15 ( MCT ) , n = 7 ( LCT ) ] . Changes in anthropometric variables , body weight and body fat during the 12-wk MCT treatment period were compared with those in subjects consuming the LCT diet . The subjects were asked to consume 9218 kJ/d and 60 g/d of total fat . The energy , fat , protein and carbohydrate intakes did not differ significantly between the groups . Body weight and body fat in both groups had decreased by wk 4 , 8 and 12 of the study . However , in the subjects with BMI > or = 23 kg/m(2 ) , the extent of the decrease in body weight was significantly greater in the MCT group than in the LCT group . In subjects with BMI > or = 23 kg/m(2 ) , the loss of body fat in the MCT group ( -3.86 + /- 0.3 kg ) was significantly greater than that in the LCT group ( -2.75 + /- 0.2 kg ) at 8 wk . In addition , in subjects with BMI > or = 23 kg/m(2 ) , the decrease in the area of subcutaneous fat in the MCT group was significantly greater than that in the LCT group at wk 4 , 8 and 12 . These results suggest that the MCT diet may reduce body weight and fat in individuals ( BMI > or = 23 kg/m(2 ) ) more than the LCT diet A double blind clinical trial was carried out to clarify the effects of oil with medium- and long-chain triglyceride ( MLCT ) on body fat and blood lipid profiles in hypertriglyceridemic subjects . One-hundred- and -twelve subjects were enrolled and divided into two groups ; those that consumed MLCT oil and those that consumed long-chain triglyceride ( LCT ) oil for 8 weeks . All subjects were requested to consume 25 - 30 g of the oils daily and maintain a fixed level of energy intake and exercise . Anthropometric and blood biochemical parameters were measured when the study was initiated and completed . The  LCT group consisted of 50 subjects ( 34 men and 16 women ) , while the MLCT group consisted of 51 subjects ( 33 men and 18 women ) who completed the study . Larger decreases in body weight , body mass index , waist circumference , body fat , total fat area and subcutaneous fat area in the abdomen and serum triglycerides , low-density lipoprotein cholesterol , apolipoprotein B , C2 , C3 and E were observed in male subjects in the MLCT group than those in the LCT group . However , no significant differences in these parameters between the female subjects in the two groups were observed . Data from this study indicate that consumption of medium- and long-chain triglycerides can reduce body weight and body fat and improve blood lipid profiles in male hypertriglyceridemic subjects In contrast to the consumption of long-chain triacylglycerols ( LCT ) , consumption of medium- and long-chain triacylglycerols ( MLCT ) reduces the body fat and blood triacylglycerols ( TAG ) level in hypertriacylglycerolemic Chinese individuals . These responses may be affected by BMI because of obesity-induced insulin resistance . We aim ed to compare the effects of consuming MLCT or LCT on reducing body fat and blood TAG level in hypertriacylglycerolemic Chinese subjects with different ranges of BMI . Employing a double-blind , r and omized and controlled protocol , 101 hypertriacylglycerolemic subjects ( including 67 men and 34 women ) were r and omly allocated to ingest 25–30 g/day MLCT or LCT oil as the only cooking oil for 8 consecutive weeks . Anthropometric measurements of body weight , BMI , body fat , WC , HC , blood biochemical variables , and subcutaneous fat area and visceral fat area in the abdomen were measured at week 0 and 8 . As compared to subjects with BMI 24–28 kg/m2 in the LCT group , corresponding subjects in the MLCT group showed significantly greater decrease in body weight , BMI , body fat , WC , ratio of WC to HC , total fat area and subcutaneous fat area in the abdomen , as well as blood TAG and LDL-C levels at week 8 . Based upon our results , consumption of MLCT oil may reduce body weight , body fat , and blood TAG and LDL-C levels in overweight hypertriacylglycerolemic Chinese subjects but may not induce these changes in normal or obese hypertriacylglycerolemic subjects We found previously that the ingestion of margarine containing medium-chain triacylglycerols ( MCT ) result ed in a significant increase in postpr and ial thermogenesis when compared with long-chain triacylglycerols ( LCT ) . Diets that included margarine containing MCT and LCT were compared for 12 weeks in 73 subjects to investigate the effects  on body weight , body fat , areas of subcutaneous and visceral fat , serum total cholesterols , triglycerides , lipoproteins , plasma glucose , serum insulin , total ketone bodies , and the activities of aspartate aminotransferase , alanine aminotransferase , and gamma-glutamyltranspeptidase . We conducted a double-blind , controlled study and used blended rapeseed oil and soybean oil ( LCT ) as a comparison . Two groups ingested 2100 - 2400 kcal/day of energy , 65 - 73 g/day of total fat , and 14 g/day of test margarine ( 5 g/day of MCT or LCT ) . The subjects on the MCT diet demonstrated significant decreases in body fat weight ( - 3.8 + /- 2.4 kg vs - 2.4 + /- 1.7 kg ; MCT vs LCT , mean + /- SD ) , subcutaneous fat ( - 38.2 + /- 29.9 cm(2 ) vs - 22.6 + /- 19.3 cm(2 ) ) , and visceral fat ( - 12.2 + /- 11.2 cm(2 ) vs - 1.6 + /- 12.8 cm(2 ) ) after 12 weeks . There were no clinical differences in measured blood parameters . We suggest that the postpr and ial increase in thermogenesis and control of postpr and ial triglyceride levels may explain these results BACKGROUND : Medium chain triglycerides ( MCT ) are energetically less dense , highly ketogenic , and more easily oxidised than long chain triglycerides ( LCT ) . MCT also differ from LCT in their digestive and metabolic pathways . OBJECTIVE : To test the effects of MCT supplementation during a very low calorie diet (VLCD).SUBJECTS AND METHODS : Three groups of tightly matched obese women with body mass index ( BMI ) > 30 kg/m2 received an isoenergetic ( 578.5 kcal )  VLCD  ( Adinax ® , Novo Vital , Sweden ) enriched with MCT or LCT ( 8.0 and 9.9 g/100 g Adinax ® respectively ) or a low-fat ( 3 g/100 g ) and high-carbohydrate regimen . The diets were administered over 4 weeks . Body composition was measured with DEXA and appetite/satiety-according to Blundell . Beta hydroxybutyric acid concentration in plasma and nitrogen excretion in urine was measured during consecutive days of VLCD . The study was performed in a r and omised double-blind manner . RESULTS : The MCT group showed a significantly greater decrease in body weight during the first 2 weeks . The contribution of body fat to the total weight loss was higher while the contribution of fat-free mass ( FFM ) was lower . The MCT group had a higher concentration of ketone bodies in plasma and a lower nitrogen excretion in urine . Hunger feelings were less intense while satiety was higher . These differences were observed during the first 2 weeks of treatment and gradually declined during the third and fourth weeks . CONCLUSIONS : Replacement of LCT by MCT in the VLCD increased the rate of decrease of body fat and body weight and has a sparing effect on FFM . The intensity of hunger feelings was lower and paralleled the higher increase of ketone bodies . These effects gradually declined , indicating subsequent metabolic adaptation . Further studies are required to confirm the protein-sparing and appetite-suppressing effects of MCT supplementation during the first 2 weeks of VLCD treatment The purpose of this study was to evaluate the fatty acid composition of chylomicron triglycerides isolated from subjects fed liquid-formula diets containing 40 % of total energy as medium- ( C8:0 and C10:0 ) or long-chain ( C16-C18 ) triglycerides ( MCT , LCT )  for 6 d. Medium-chain fatty acids ( MCFA ) comprised 8 % of total chylomicron triglyceride fatty acids after the first MCT meal . After 6 d of continued MCT feeding , chylomicron triglyceride MCFA content increased to 13 % . When subjects were fed the LCT ( soybean oil ) diet , C16:0 , C18:1 , and C18:2 comprised nearly 90 % of the chylomicron triglyceride fatty acids . The mass of triglyceride transported in chylomicrons isolated from subjects fed the MCT diet was approximately 20 % of that found when subjects consumed the LCT diet . We conclude that although total triglyceride production during MCT ingestion is low , the chylomicron triglycerides that are synthesized contain significant amounts of MCFA OBJECTIVE : Assessment of the effect of 2-week supplementation with (−)-hydroxycitrate ( HCA ) and HCA combined with medium-chain triglycerides ( MCT ) on satiety , fat oxidation , energy expenditure ( EE ) and body weight ( BW ) loss . DESIGN : Three intervention periods of 2 weeks separated by washout periods of 4 weeks . Double-blind , placebo-controlled , r and omised and cross-over design .SUBJECTS : Eleven overweight male subjects ( mean±s.d . ; age , 47±16 y ; body mass index , 27.4 ± 8.2 kg/m2).INTERVENTION : Subjects consumed three self-selected meals and four iso-energetic ( 420 kJ ) snacks daily with either no supplementation ( PLA ) , 500 mg HCA ( HCA ) or 500 mg HCA and 3 g MCT ( HCA+MCT ) . Each intervention ended with a 36 h stay in the respiration chamber . RESULTS : There was a significant BW loss during the 2 weeks of intervention ( PLA , −1.0 ± 0.4 kg , P<0.05 ; HCA , −1.5 ± 0.5 kg , P<0.01 ; HCA+MCT , −1.3 ± 0.2 kg , P<0.001 ) , but this reduction was not different between treatments . 24 h EE  ( PLA , 11.8 ± 0.2 MJ ; HCA , 11.7 ± 0.1 MJ ; HCA+MCT , 11.5 ± 0.1 MJ ) , 24 h RQ ( 0.85 ± 0.00 in all treatments ) and the area under the curve of the appetite-related parameters were not different between treatments . CONCLUSION : Two-week supplementation with HCA and HCA combined with MCT did not result in increased satiety , fat oxidation , 24 h EE or BW loss  compared to PLA , in subjects losing BW The possible beneficial effects of infusing a lipid emulsion containing 50 % by weight of medium-chain triglycerides ( MCT ) compared with a st and ard long-chain triglyceride ( LCT ) emulsion were studied in 18 premature neonates ( gestational age less than 34 weeks ) requiring parenteral nutrition . The infants were assigned in a double-blind manner to receive one of the two lipid emulsions over 17 hours a day as a supplemental regimen for total parenteral nutrition . A lipid load of 1 g/kg per day was initiated on the third day of life and was increased at the rate of 1 g/kg per day until a maximal dose of 3 g/kg per day was obtained on the fifth day of life and maintained thereafter . Both bound and unbound bilirubin decreased with both infusion regimens during the study period . Despite a marked increase in plasma free fatty acid levels ( 260 % in the MCT/LCT group compared with 210 % in the LCT group ) , the fraction of unbound ( free ) bilirubin was significantly lower in the MCT/LCT group ( 34 % vs 13 % ) . Free fatty acid levels , corrected to albumin , were positively correlated to the percentage of free bilirubin only for the LCT lipid infusion . The finding of a significant elevation of plasma cholesterol levels only in the MCT/LCT group is now under investigation . Use of the MCT-containing emulsion was not associated with a higher frequency of adverse effects than the commonly used LCT-containing emulsion . ( ABSTRACT TRUNCATED AT 250 WORDS Background Impaired brain glucose metabolism appears to be a potential pathogenic feature of mild cognitive impairment ( MCI ) . This study examined the potential for increasing circulating ketone bodies through medium chain triglyceride ( MCT ) supplementation , as a means to beneficially modulate brain homeostasis in subjects with MCI . Methods Six participants with MCI were enrolled in a r and omized placebo-controlled trial . Participants received 56 g/day of either medium chain triglycerides ( MCTs ) or placebo for 24 weeks . Serum β-hydroxybutyrate concentrations , apolipoprotein-E4 status , and cognitive assessment s were carried out . Due to the small number of participants only the raw scores were examined . Results Intake of MCT oil  increased serum ketone bodies and improved memory , while intake of placebo did not show improvement in any of the cognitive measures tested . Conclusions Consumption of 56 g/day of MCTs for 24 weeks increases serum ketone concentrations and appears to be a c and i date for larger r and omized control trials in the future that quantify the modulation of cognitive function through supplementation with ketone precursors , in patients with MCI We investigated whether a structured medium- and long-chain triacylglycerols ( MLCT ) diet could decrease accumulation of body fat in healthy humans . The study was conducted under a double-blind r and omized design . Ninety-three subjects participated in this study . However , 10 subjects could not consume the specified meal , and one subject wished to opt out . Consequently , the study included 82 subjects . The experimental subjects consumed the test bread , which was made with 14 g of MLCT containing 1.7 g MCFA , daily at breakfast during the study period of 12 weeks , and the control subjects consumed bread made with long-chain triacylglycerols ( LCT ) . All subjects consumed the same st and ard packaged meals .  Body composition parameters were body weight , total body fat and abdominal fat , and blood analyses included serum cholesterol , triacylglycerols and phospholipids . Significant decreases of body weight , the amount of body fat , subcutaneous and visceral fat were noted in the MLCT group as compared with those of the LCT group for 12 weeks ( P<0.05 ) . Furthermore , a significant decrease in serum total cholesterol was noted in the MLCT group as compared with that of the LCT group at 8 weeks ( P<0.05 ) . However , other serum parameters were not different between the MLCT and LCT groups . The results suggest that the daily intake of MLCT diet could result in a reduction in body weight and in accumulation of body fat , and , moreover , it could reduce serum total cholesterol Objectives : To investigate the effects of medium- and long-chain triacylglycerol ( MLCT ) on blood triglyceride ( TG ) in Chinese hypertriglyceridemic subjects . Methods : A double-blind controlled clinical trial was carried out , in which 112 subjects with hypertriglyceridemia were r and omly divided into two dietary oil groups : ( 1 ) long-chain triacylglycerol ( LCT ) and ( 2 ) MLCT . All subjects were requested to ingest fixed energy and to continue their normal activity levels , and to consume LCT or MLCT oil at 25–30 g daily during the study period . Anthropometric measurements of body weight , body mass index ( BMI ) , body fat , body fat percentage , waist and hip circumference ( WC and HC ) , areas of subcutaneous and visceral fat by computed tomography scanning and blood biochemical markers were measured at the beginning and end of the study . Results : There were 50 and 51 subjects left in LCT and MLCT groups , respectively . There were no significant differences in daily intake of energy , protein , fat and carbohydrate , as well as the daily physical activity between the two groups during the study . After 8 weeks , MLCT group showed a significant decrease in body weight , BMI , WC , HC , ratio of WC and HC , body fat , body fat percentage and subcutaneous fat when compared with the initial values . The decrease in body weight , BMI , WC , body fat and subcutaneous and visceral fat was significantly greater in MLCT group than that in the LCT group . Furthermore , the serum concentrations of TG in MLCT group were significantly lower than those in the LCT group . Conclusions : Consumption of MLCT may reduce body weight , body fat and blood TG in hypertriglyceridemic subjects under an appropriate dietary regime BACKGROUND SMOFlipid 20 % is intravenous lipid emulsion ( ILE ) containing long-chain triglycerides ( LCT ) , medium-chain triglycerides ( MCT ) , olive oil , and fish oil as a mixed emulsion containing α-tocopherol . The aim was to assess the efficacy of this new ILE in gastrointestinal surgery compared with MCT/LCT . METHODS In this prospect i ve study , 40 patients were r and omized to SMOFlipid 20 % or MCT/LCT ( Lipovenoes 20 % ) group . Clinical and biochemistry data were collected . Inflammatory markers ( CRP , IL-6 , IL-10 , TNF-α , TGF-β1 ) and oxidative stress ( ROS and superoxide ) were measured . RESULTS Thirty-five patients ( 17 males and 18 females ) with a mean age of 57 years completed the study . The patients ' demographic characteristics ( age , gender , height , body weight , and BMI ) were similar without significant differences between groups . The increment of triglyceride on day 6 from baseline was significantly lower in SMOFlipid group than in Lipovenoes MCT/LCT group . Inflammatory markers , as well as superoxide radical and total oxygen radical were not different between groups . CONCLUSIONS Despite the comparable effect on inflammatory response , because of its well-balanced fatty acid pattern , relatively low n-6:n-3 ratio , and high vitamin E content , SMOFlipid had a better triglyceride-lowering effect as compared with MCT/LCT in adult patients undergoing gastrointestinal surgery
No differences were seen in blood lipid levels .
Replacement of LCTs with MCTs in the diet could potentially induce modest reductions in body weight and composition without adversely affecting lipid profiles .
BACKGROUND Medium-chain triglycerides ( MCTs ) may result in negative energy balance and weight loss through increased energy expenditure and lipid oxidation .
However , results from human intervention studies investigating the weight reducing potential of MCTs , have been mixed .
OBJECTIVE To conduct a systematic review and meta- analysis of r and omized controlled trials comparing the effects of MCTs , specifically C8:0 and C10:0 , to long-chain triglycerides ( LCTs )  on weight loss and body composition in adults .