When mice ate a diet of 25 percent extra sugar -- the mouse equivalent of a healthy human diet plus three cans of soda daily -- females died at twice the normal rate and males were a quarter less likely to hold territory and reproduce, according to a toxicity test developed at the University of Utah. 
 
 "Our results provide evidence that added sugar consumed at concentrations currently considered safe exerts dramatic adverse impacts on mammalian health," the researchers say in a study set for online publication Tuesday, Aug. 13 in the journal Nature Communications. 
 
 "This demonstrates the adverse effects of added sugars at human-relevant levels," says University of Utah biology professor Wayne Potts, the study's senior author. He says previous studies using other tests fed mice large doses of sugar disproportionate to the amount people consume in sweetened beverages, baked goods and candy. 
 
 "I have reduced refined sugar intake and encouraged my family to do the same," he adds, noting that the new test showed that the 25 percent "added-sugar" diet -- 12.5 percent dextrose (the industrial name for glucose) and 12.5 percent fructose -- was just as harmful to the health of mice as being the inbred offspring of first cousins. 
 
 Even though the mice didn't become obese and showed few metabolic symptoms, the sensitive test showed "they died more often and tended to have fewer babies," says the study's first author, James Ruff, who recently earned his Ph.D. at the University of Utah. "We have shown that levels of sugar that people typically consume -- and that are considered safe by regulatory agencies -- impair the health of mice." 
 
 The new toxicity test placed groups of mice in room-sized pens nicknamed "mouse barns" with multiple nest boxes -- a much more realistic environment than small cages, allowing the mice to compete more naturally for mates and desirable territories, and thereby revealing subtle toxic effects on their performance, Potts says. 
 
 "This is a sensitive test for health and vigor declines," he says, noting that in a previous study, he used the same test to show how inbreeding hurt the health of mice. 
 
 "One advantage of this assay is we get the same readout no matter if we are testing inbreeding or added sugar," Potts says. "The mice tell us the level of health degradation is almost identical" from added-sugar and from cousin-level inbreeding. 
 
 The study says the need for a sensitive toxicity test exists not only for components of our diet, but "is particularly strong for both pharmaceutical science, where 73 percent of drugs that pass preclinical trials fail due to safety concerns, and for toxicology, where shockingly few compounds receive critical or long-term toxicity testing." 
 
 The study was funded by the National Institutes of Health and the National Science Foundation. 
 
 A Mouse Diet Equal to What a Quarter of Americans Eat 
 
 The experimental diet in the study provided 25 percent of calories from added sugar -- half fructose and half glucose -- no matter how many calories the mice ate. Both high-fructose corn syrup and table sugar (sucrose) are half fructose and half glucose. 
 
 Potts says the National Research Council recommends that for people, no more than 25 percent of calories should be from "added sugar," which means "they don't count what's naturally in an apple, banana, potato or other nonprocessed food. … The dose we selected is consumed by 13 percent to 25 percent of Americans." 
 
 The diet fed to the mice with the 25 percent sugar-added diet is equivalent to the diet of a person who drinks three cans daily of sweetened soda pop "plus a perfectly healthy, no-sugar-added diet," Potts says. 
 
 Ruff notes that sugar consumption in the American diet has increased 50 percent since the 1970s, accompanied by a dramatic increase in metabolic diseases such as diabetes, obesity, fatty liver and cardiovascular disease. 
 
 The researchers used a mouse supply company that makes specialized diets for research. Chow for the mice was a highly nutritious wheat-corn-soybean mix with vitamins and minerals. For experimental mice, glucose and fructose amounting to 25 percent of calories was included in the chow. For control mice, corn starch was used as a carbohydrate in place of the added sugars. 
 
 House Mice Behaving Naturally 
 
 Mice often live in homes with people, so "mice happen to be an excellent mammal to model human dietary issues because they've been living on the same diet as we have ever since the agricultural revolution 10,000 years ago," Potts says. 
 
 Mice typically used in labs come from strains bred in captivity for decades. They lack the territoriality shown by wild mice. So the study used mice descended from wild house mice that were "outbred" to prevent inbreeding typical of lab mice. 
 
 "They are highly competitive over food, nesting sites and territories," he says. "This competition demands high performance from their bodies, so if there is a defect in any physiological systems, they tend to do more poorly during high competition." 
 
 So Potts' new test -- named the Organismal Performance Assay, or OPA -- uses mice "in a more natural ecological context" more likely to reveal toxic effects of whatever is being tested, he says. 
 
 "When you look at a mouse in a cage, it's like trying to evaluate the performance of a car by turning it on in a garage," Ruff says. "If it doesn't turn on, you've got a problem. But just because it does turn on, doesn't mean you don't have a problem. To really test it, you take it out on the road." 
 
 A big room was divided into 11 "mouse barns" used for the new test. Six were used in the study. Each "barn" was a 377-square-foot enclosure ringed by 3-foot walls. 
 
 Each mouse barn was divided by wire mesh fencing into six sections or "territories," but the mice could climb easily over the mesh. Within each of the six sections was a nest box, a feeding station and drinking water. 
 
 Four of the six sections in each barn were "optimal," more desirable territories because the nest boxes were opaque plastic storage bins, which mice entered via 2-inch holes at the bottom. Each bin had four nesting cages in it, and an enclosed feeder. 
 
 The two other sections were "suboptimal" territories with open planter trays instead of enclosed bins. Female mice had to nest communally in the trays. 
 
 Running the Experiment 
 
 The mice in the experiment began with 156 "founders" that were bred in Potts' colony, weaned at four weeks, and then assigned either to the added-sugar diet or the control diet, with half the males and half the females on each diet. 
 
 The mice stayed in cages with siblings of the same sex (to prevent reproduction) for 26 weeks while they were fed these diets. Then the mice were placed in the mouse barns to live, compete with each other and breed for 32 more weeks. They all received the same added-sugar diet while in the mouse barns, so the study only tested for differences caused by the mice eating different diets for the previous 26 weeks. 
 
 The founder mice had implanted microchips, like those put in pets. Microchip readers were placed near the feeding stations to record which mice fed where and for how long. A male was considered dominant if he made more than 75 percent of the visits by males to a given feeding station. In reality, the dominant males made almost 100 percent of male visits to the feeder in the desirable territory they dominated. 
 
 With the 156 founder mice (58 male, 98 female), the researchers ran the experiment six times, with an average of 26 mice per experiment: eight to 10 males (competing for six territories, four desirable and two suboptimal) and 14 to 18 females. 
 
 The Findings: Added Sugar Impairs Mouse Lifespan and Reproduction 
 
 -- After 32 weeks in mouse barns, 35 percent of the females fed extra sugar died, twice the 17 percent death rate for female control mice. There was no difference in the 55 percent death among males who did and did not get added sugar. Ruff says males have much higher death rates than females in natural settings because they compete for territory, "but there's no relation to sugar." 
 
 -- Males on the added-sugar diet acquired and held 26 percent fewer territories than males on the control diet: control males occupied 47 percent of the territories while sugar-added mice controlled less than 36 percent. Male mice shared the remaining 17 percent of territories. 
 
 -- Males on the added-sugar diet produced 25 percent fewer offspring than control males, as determined by genetic analysis of the offspring. The sugar-added females had higher reproduction rates than controls initially -- likely because the sugar gave them extra energy to handle the burden of pregnancy -- but then had lower reproductive rates as the study progressed, partly because they had higher death rates linked to sugar. 
 
 The researchers studied another group of mice for metabolic changes. The only differences were minor: cholesterol was elevated in sugar-fed mice, and the ability to clear glucose from the blood was impaired in female sugar-fed mice. The study found no difference between mice on a regular diet and mice with the 25 percent sugar-added diet when it came to obesity, fasting insulin levels, fasting glucose or fasting triglycerides. 
 
 "Our test shows an adverse outcome from the added-sugar diet that couldn't be detected by conventional tests," Potts says. 
 
 Human-made toxic substances in the environment potentially affect all of us, and more are continually discovered, Potts says. 
 
 "You have to ask why we didn't discover them 20 years ago," he adds. "The answer is that until now, we haven't had a functional, broad and sensitive test to screen the potential toxic substances that are being released into the environment or in our drugs or our food supply." 
 
 Potts and Ruff conducted the study with University of Utah biology lab manager Linda Morrison and undergraduates Amanda Suchy, Sara Hugentobler, Mirtha Sosa and Bradley Schwartz, and with researchers Sin Gieng and Mark Shigenaga of Children's Hospital Oakland Research Institute in California. ||||| Nobody would mistake sugary soda for a health food, but a new study published in the American Journal of Public Health just found that a daily soda habit can age your immune cells almost two years. 
 
 Senior study author Elissa Epel, PhD, professor of psychiatry at University of California San Francisco, wanted to look at the mechanisms behind soda’s storied link to conditions like diabetes, heart attack, obesity, and even higher rates of death. She studied telomeres, the caps at the end of chromosomes in every cell in our body, from white blood cells. Shorter telomeres have been linked to health detriments like shorter lifespans and more stress, cardiovascular disease, diabetes and cancer, the study notes. 
 
 Epel and her team analyzed data from 5,309 adults in the National Health and Nutrition Examination Survey (NHANES) from about 14 years ago. They found that people who drank more sugary soda tended to have shorter telomeres. Drinking an 8-ounce daily serving of soda corresponded to 1.9 years of additional aging, and drinking a daily 20-ounce serving was linked to 4.6 more years of aging. The latter, the authors point out, is exactly the same association found between telomere length and smoking. 
 
 Only the sugary, bubbly stuff showed this effect. Epel didn’t see any association between telomere length and diet soda intake. “The extremely high dose of sugar that we can put into our body within seconds by drinking sugared beverages is uniquely toxic to metabolism,” she says. 
 
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 She also didn’t see a significant link between non-carbonated sugary beverages, like fruit juice, which Epel says surprised her. But she thinks the results might be different if the data were more modern. “We think that the jury’s still out on sugared beverages—theoretically they’re just as bad,” she says. “But 14 years ago people were drinking a lot less sugared beverages…they were mostly drinking soda.” At the time of the study, 21% of adults in the study reported consuming 20 ounces or more of sugar-sweetened soda each day, but soda consumption has been on the decline for years. 
 
 Telomere length dwindles naturally as we age, but it may not be an irreversible process. Previous research shows that it’s possible to increase telomere length by as much as 10% over 5 years by stressing less and eating a healthy diet—no soda included. 
 
 Read next: Here’s How to Stop Teens From Drinking Soda 
 
 Write to Mandy Oaklander at mandy.oaklander@time.com.
– A steady diet of sodas could hinder your ability to reproduce or even shorten your life, if lab mice are any indication. Researchers at the University of Utah gave mice a diet of 25% sugar—equivalent to three extra sodas per day in people—and found the males less likely to reproduce or defend their territory, the Salt Lake Tribune reports. Females had it worse, dying at double their normal rate. And to think, the National Research Council tells us that this level of added sugar is considered safe in humans. "Added sugar consumed at concentrations currently considered safe exerts dramatic adverse impacts on mammalian health," the study says, according to Science Daily. Yet the mice weren't fatter and would have passed physicals, despite the negative health impacts—so the sugar's toxic damage is all "under the hood." Why rely on a study of mice? They're considered roughly equivalent to humans in dietary studies because they've had a similar diet to ours for about 10,000 years, and up to 80% of what's toxic to them is toxic to people, too.