The drug company CEO under fire for boosting the cost of a decades-old medicine by 50-fold defended the decision, calling the treatment a bargain at $750 a pill. 
 
 Martin Shkreli, a former hedge fund manager who is now chief executive officer of Turing Pharmaceuticals AG, was called out by Democratic presidential candidate Hillary Clinton. Clinton tweeted that she would soon release a plan to combat the high cost of prescription drugs. Biotechnology stocks fell after her comment. 
 
 Clinton’s comment on Twitter sent the 144-member Nasdaq Biotechnology Index down 4.7 percent to 3,556.58 at 1:08 p.m. in New York, the biggest intraday drop since Aug. 24. Health-care stocks were the worst-performing subgroup on the broader Nasdaq index. 
 
 "Price gouging like this in the specialty drug market is outrageous," Clinton tweeted at 10:56 a.m. "Tomorrow I’ll lay out a plan to take it on." 
 
 Turing’s price increase risks making Shkreli’s company a poster child for aggressive pricing by the industry, especially after drugmakers have already been criticized for the cost of medicines to treat cancer, hepatitis C and other conditions. 
 
 Clinton was responding to reports about how Turing Pharmaceuticals in August acquired an older antibiotic drug, Daraprim, and subsequently raised the price by more than 50-fold. 
 
 Shkreli said the drug, which once sold for $13.50 per pill and for which Turing now charges $750, is still a bargain even at the new higher price. Patients typically take the drug for at least several weeks. 
 
 "This drug saves your life for $50,000," Shkreli said in an interview in New York. "It is still a bargain for health insurers. At this price, it is a no-brainer." The drug is very inexpensive for Turing to manufacture, Shkreli said during an interview Monday with Bloomberg TV, though there are other administrative and regulatory costs for the company. 
 
 About 2,000 Americans use Daraprim each year, which treats the disease toxoplasmosis. While the parasite that causes the disease is common, it doesn’t usually cause symptoms, and typically only needs to be treated in patients with compromised immune systems. 
 
 Many drugs for rare diseases have to be taken continuously for years, and cost $100,000 to $500,000 a year. By contrast, Daraprim treats patients in about six weeks, limiting the cost, Shkreli said. 
 
 Higher Costs? 
 
 Joel Gallant, a doctor and the former chairman of the HIV Medicine Association, disputed Shkreli’s comments about how the drug is used and for how long. HIV patients are particularly susceptible to toxoplasmosis, and many patients remain on lower doses for months or years. 
 
 "This is hundreds of thousands of dollars," Gallant said, referring to the cost for HIV patients with the disease. 
 
 "They are not in the game for biomedical research," he said in an interview. "They are getting exclusive rights to a cheap drug and raising the price because they can." Because of the cost, hospitals may not be able to stock the drug, causing delays in treatment Gallant said. 
 
 Shkreli didn’t immediately respond to an e-mail and telephone call requesting additional comment. 
 
 Aggressive Pricing 
 
 “We can understand why examples like these raise questions," said Robert Zirkelbach, a spokesman for Pharmaceutical Research and Manufacturers of America, which represents drug company interests. "However, Turing is not a member company and we are not in the position to comment on their product or pricing." He called Turing’s price for Daraprim "the exception and not the rule." 
 
 A drug price plan could be a part of a group of health proposals from Clinton, who said Sunday on the television program "Face the Nation" that she had several ideas on health care. 
 
 "I’m going to address them this week, starting with how we’re going to try to control the cost of skyrocketing prescription drugs," she said. "It’s something that I hear about wherever I go." 
 
 The biotechnology index was already vulnerable and Clinton’s tweet was likely a major factor in the decline, said John Fraunces, portfolio manager of Turner Medical Sciences Fund, said by phone. "Pricing is a theme that seems to be of growing concern in the health-care area, ourselves included." 
 
 Terry Haines, a political analyst with Evercore ISI, didn’t think Clinton could actually have an impact. "Regardless of what any Democratic candidate says about drug pricing, his or her ability to make that a reality as president is close to zero." Haines said in a note to clients that he doubted a drug pricing proposal could get through Congress. 
 
 Research 
 
 Shkreli said that unlike many other drugmakers that also take huge price increases on old drugs, his company is investing in research to come up with better drug for toxoplasmosis. Researchers at Turing have identified several new candidate drugs, one of which could begin human trials next year, he said. He said he wants to come out with a better version of Daraprim with higher cure rates or fewer side effects. 
 
 Gallant, the HIV doctor, said Daraprim is already highly effective in combination with other drugs. "No one has been clamoring" for more toxoplasmosis drug research, he said. 
 
 Turing "is being criticized for trying to stay alive," Shkreli said. "It is very misplaced anger." At the old price, there was no way to turn a profit, he said. 
 
 Shkreli said the company had put assistance systems in place to make sure that all patients who need the drug can get it even if their insurance company won’t pay for it. 
 
 For more, read this next: 
 
 • QuickTake: Access to Drugs ||||| Martin Shkreli, the hedge fund manager and latest poster boy for Wall Street greed, now says he regrets not increasing the price of a life-saving drug by more than he already did. 
 
 Asked by an audience member at a healthcare summit hosted by Forbes on Thursday what he'd do differently if he could go back in time to before his highly criticized decision to raise the price of a 62-year-old drug, he replied: "I probably would have raised prices higher, is probably what I should have done. I could have raised it higher and made more profits for our shareholders. Which is my primary duty." 
 
 The price hike, which took a a pill of Daraprim from $13.50 to $750 a piece overnight, drew a strong backlash. Daraprim was initially developed to treat toxoplasmosis, which strikes people with compromised immune systems. 
 
 The Turing Pharmaceuticals CEO went on to say, "No one wants to say it, no one's proud of it, but this is a capitalist society, capitalist system and capitalist rules, and my investors expect to me to maximize profits, not to minimize them, or go half, or go 70 percent, but to go to 100 percent of the profit curve that we're all taught in MBA class." 
 
 Last week, Turing said the list price of Daraprim would not change, but it would offer hospitals as much as 50 percent discounts. 
 
 On Tuesday, Express Scripts (ESRX) said it would partner with Imprimis Pharmaceuticals (IMMY) to within days offer a low-cost alternative to Daraprim, saying the drug had been "recently priced out of reach for people with HIV, pregnant women and others with weakened immune systems." 
 
 The goal is "to counterbalance companies like Turing and others in order to address the growing drug pricing crisis in America," Mark Baum, CEO of Imprimis, said in a statement. 
 
 A U.S. Senate committee is investigating the price increases at Turing and other drug companies, with a hearing on the issue scheduled for Dec. 9. U.S. prescription drug prices rose 13.1 percent in 2014, the largest increase since 2003, according to pharmacy benefits manager Express Scripts.
– "This isn't the greedy drug company trying to gouge patients, it is us trying to stay in business. It really doesn't make sense to get any criticism for this." The "this" Martin Shkreli is referring to is the price hike his company instituted after it last month acquired Daraprim, a 62-year-old drug that the New York Times describes as "the standard of care" for treating those suffering from the potentially deadly parasitic infection toxoplasmosis. The overnight change made by start-up Turing Pharmaceuticals: from $13.50 a tablet to $750 a tablet. USA Today points out that's a 5,000% increase. Shkreli justified the move by saying the overall impact will be a minor one as there are only 12,000 or so prescriptions for the specialized drug a year, and because the proceeds will go toward developing a newer treatment with fewer side effects. A professor of infectious diseases at Emory University isn't so sure about that plan. She tells the Times that while the drug is accompanied by potentially serious side effects, they're manageable. "I certainly don't think this is one of those diseases where we have been clamoring for better therapies," says Dr. Wendy Armstrong. The Times charts the drug's price history: Its 2010 acquisition by CorePharma saw its price hiked from $1 a tablet; that raised sales of the drug from $667,000 in 2010 to $6.3 million in 2011. The most recent price increase could push those sales into the hundreds of millions. As for what Daraprim treats, the CDC describes toxoplasmosis as "a leading cause of death attributed to foodborne illness" in the US. While some 60 million Americans are thought to carry the Toxoplasma parasite, it causes illness in those with weakened immune systems.