Supervised deep learning relies on the assumption that enough training data is available, which presents a problem for its application to several fields, like medical imaging. On the example of a binary image classification task (breast cancer recognition), we show that pretraining a generative model for meaningful image augmentation helps enhance the performance of the resulting classifier. By augmenting the data, performance on downstream classification tasks could be improved even with a relatively small training set. We show that this "adversarial augmentation" yields promising results compared to classical image augmentation on the example of breast cancer classification.
Generative Adversarial Networks (GANs), proposed by , have shown great potential for generating or modifying images. Many studies focused on image augmentation using GANs @cite_12 @cite_8 @cite_9 . The application to the medical domain is logical, because it is generally difficult to obtain data there, and all datasets are naturally heavily imbalanced. focuses on brain MRI augmentation using paired image-to-image translation similar to the pix2pix approach @cite_28 .
@cite_28 @cite_9 @cite_12 @cite_8
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Generative Adversarial Networks (GANs) have been successfully used to synthesize realistically looking images of faces, scenery and even medical images. Unfortunately, they usually require large training datasets, which are often scarce in the medical field, and to the best of our knowledge GANs have been only applied for medical image synthesis at fairly low resolution. However, many state-of-the-art machine learning models operate on high resolution data as such data carries indispensable, valuable information. In this work, we try to generate realistically looking high resolution images of skin lesions with GANs, using only a small training dataset of 2000 samples. The nature of the data allows us to do a direct comparison between the image statistics of the generated samples and the real dataset. We both quantitatively and qualitatively compare state-of-the-art GAN architectures such as DCGAN and LAPGAN against a modification of the latter for the task of image generation at a resolution of 256x256px. Our investigation shows that we can approximate the real data distribution with all of the models, but we notice major differences when visually rating sample realism, diversity and artifacts. In a set of use-case experiments on skin lesion classification, we further show that we can successfully tackle the problem of heavy class imbalance with the help of synthesized high resolution melanoma samples. Generative Adversarial Network (GAN) is a prominent generative model that are widely used in various applications. Recent studies have indicated that it is possible to obtain fake face images with a high visual quality based on this novel model. If those fake faces are abused in image tampering, it would cause some potential moral, ethical and legal problems. In this paper, therefore, we first propose a Convolutional Neural Network (CNN) based method to identify fake face images generated by the current best method [20], and provide experimental evidences to show that the proposed method can achieve satisfactory results with an average accuracy over 99.4 . In addition, we provide comparative results evaluated on some variants of the proposed CNN architecture, including the high pass filter, the number of the layer groups and the activation function, to further verify the rationality of our method. Generative adversarial networks (GANs) are recently highly successful in generative applications involving images and start being applied to time series data. Here we describe EEG-GAN as a framework to generate electroencephalographic (EEG) brain signals. We introduce a modification to the improved training of Wasserstein GANs to stabilize training and investigate a range of architectural choices critical for time series generation (most notably up- and down-sampling). For evaluation we consider and compare different metrics such as Inception score, Frechet inception distance and sliced Wasserstein distance, together showing that our EEG-GAN framework generated naturalistic EEG examples. It thus opens up a range of new generative application scenarios in the neuroscientific and neurological context, such as data augmentation in brain-computer interfacing tasks, EEG super-sampling, or restoration of corrupted data segments. The possibility to generate signals of a certain class and or with specific properties may also open a new avenue for research into the underlying structure of brain signals. We propose a new recurrent generative adversarial architecture named RNN-GAN to mitigate imbalance data problem in medical image semantic segmentation where the number of pixels belongs to the desired object are significantly lower than those belonging to the background. A model trained with imbalanced data tends to bias towards healthy data which is not desired in clinical applications and predicted outputs by these networks have high precision and low recall. To mitigate imbalanced training data impact, we train RNN-GAN with proposed complementary segmentation mask, in addition, ordinary segmentation masks. The RNN-GAN consists of two components: a generator and a discriminator. The generator is trained on the sequence of medical images to learn corresponding segmentation label map plus proposed complementary label both at a pixel level, while the discriminator is trained to distinguish a segmentation image coming from the ground truth or from the generator network. Both generator and discriminator substituted with bidirectional LSTM units to enhance temporal consistency and get inter and intra-slice representation of the features. We show evidence that the proposed framework is applicable to different types of medical images of varied sizes. In our experiments on ACDC-2017, HVSMR-2016, and LiTS-2017 benchmarks we find consistently improved results, demonstrating the efficacy of our approach. We introduce a novel generative autoencoder network model that learns to encode and reconstruct images with high quality and resolution, and supports smooth random sampling from the latent space of the encoder. Generative adversarial networks (GANs) are known for their ability to simulate random high-quality images, but they cannot reconstruct existing images. Previous works have attempted to extend GANs to support such inference but, so far, have not delivered satisfactory high-quality results. Instead, we propose the Progressively Growing Generative Autoencoder (Pioneer) network which achieves high-quality reconstruction with (128 128 ) images without requiring a GAN discriminator. We merge recent techniques for progressively building up the parts of the network with the recently introduced adversarial encoder–generator network. The ability to reconstruct input images is crucial in many real-world applications, and allows for precise intelligent manipulation of existing images. We show promising results in image synthesis and inference, with state-of-the-art results in CelebA inference tasks. Conditional Generative Adversarial Networks (GANs) for cross-domain image-to-image translation have made much progress recently. Depending on the task complexity, thousands to millions of labeled image pairs are needed to train a conditional GAN. However, human labeling is expensive, even impractical, and large quantities of data may not always be available. Inspired by dual learning from natural language translation, we develop a novel dual-GAN mechanism, which enables image translators to be trained from two sets of unlabeled images from two domains. In our architecture, the primal GAN learns to translate images from domain U to those in domain V, while the dual GAN learns to invert the task. The closed loop made by the primal and dual tasks allows images from either domain to be translated and then reconstructed. Hence a loss function that accounts for the reconstruction error of images can be used to train the translators. Experiments on multiple image translation tasks with unlabeled data show considerable performance gain of DualGAN over a single GAN. For some tasks, DualGAN can even achieve comparable or slightly better results than conditional GAN trained on fully labeled data. Conditional Generative Adversarial Networks (GANs) for cross-domain image-to-image translation have made much progress recently [7, 8, 21, 12, 4, 18]. Depending on the task complexity, thousands to millions of labeled image pairs are needed to train a conditional GAN. However, human labeling is expensive, even impractical, and large quantities of data may not always be available. Inspired by dual learning from natural language translation [23], we develop a novel dual-GAN mechanism, which enables image translators to be trained from two sets of unlabeled images from two domains. In our architecture, the primal GAN learns to translate images from domain U to those in domain V, while the dual GAN learns to invert the task. The closed loop made by the primal and dual tasks allows images from either domain to be translated and then reconstructed. Hence a loss function that accounts for the reconstruction error of images can be used to train the translators. Experiments on multiple image translation tasks with unlabeled data show considerable performance gain of DualGAN over a single GAN. For some tasks, DualGAN can even achieve comparable or slightly better results than conditional GAN trained on fully labeled data. Generative adversarial network (GAN) has shown its powerful capability in generating photorealistic images. Although the generated images can fool human eyes, it is not clear whether they can evade the detection of forensic detectors, which aim to identify the originality and authenticity of images. In this paper, we investigate how forensic detectors perform in differentiating between GAN generated images and real images. We consider two kinds of approaches, one is intrusive and the other is non-intrusive, based on whether the GAN architecture is needed for performing detection. We have conducted extensive experiments on a celebrity face image dataset to evaluate the effectiveness of different approaches. The results and analyses show that the intrusive approach can detect GAN generated images but with a relatively high false alarm rate. The non-intrusive approach with features extracted from a VGG network is very effective for detecting GAN generated images when the training data is sufficient, but it still faces challenge when the training data and testing data are mismatched. Image completion has achieved significant progress due to advances in generative adversarial networks (GANs). Albeit natural-looking, the synthesized contents still lack details, especially for scenes with complex structures or images with large holes. This is because there exists a gap between low-level reconstruction loss and high-level adversarial loss. To address this issue, we introduce a perceptual network to provide mid-level guidance, which measures the semantical similarity between the synthesized and original contents in a similarity-enhanced space. We conduct a detailed analysis on the effects of different losses and different levels of perceptual features in image completion, showing that there exist complementarity between adversarial training and perceptual features. By combining them together, our model can achieve nearly seamless fusion results in an end-to-end manner. Moreover, we design an effective lightweight generator architecture, which can achieve effective image inpainting with far less parameters. Evaluated on CelebA Face and Paris StreetView dataset, our proposed method significantly outperforms existing methods. Although Generative Adversarial Networks (GANs) have shown remarkable success in various tasks, they still face challenges in generating high quality images. In this paper, we propose Stacked Generative Adversarial Networks (StackGAN) aiming at generating high-resolution photo-realistic images. First, we propose a two-stage generative adversarial network architecture, StackGAN-v1, for text-to-image synthesis. The Stage-I GAN sketches the primitive shape and colors of the object based on given text description, yielding low-resolution images. The Stage-II GAN takes Stage-I results and text descriptions as inputs, and generates high-resolution images with photo-realistic details. Second, an advanced multi-stage generative adversarial network architecture, StackGAN-v2, is proposed for both conditional and unconditional generative tasks. Our StackGAN-v2 consists of multiple generators and discriminators in a tree-like structure; images at multiple scales corresponding to the same scene are generated from different branches of the tree. StackGAN-v2 shows more stable training behavior than StackGAN-v1 by jointly approximating multiple distributions. Extensive experiments demonstrate that the proposed stacked generative adversarial networks significantly outperform other state-of-the-art methods in generating photo-realistic images. Generative Adversarial Networks (GANs) have shown great promise recently in image generation. Training GANs for language generation has proven to be more difficult, because of the non-differentiable nature of generating text with recurrent neural networks. Consequently, past work has either resorted to pre-training with maximum-likelihood or used convolutional networks for generation. In this work, we show that recurrent neural networks can be trained to generate text with GANs from scratch using curriculum learning, by slowly teaching the model to generate sequences of increasing and variable length. We empirically show that our approach vastly improves the quality of generated sequences compared to a convolutional baseline. In this work, we present a novel approach for training Generative Adversarial Networks (GANs). Using the attention maps produced by a Teacher- Network we are able to improve the quality of the generated images as well as perform weakly object localization on the generated images. To this end, we generate images of HEp-2 cells captured with Indirect Imunofluoresence (IIF) and study the ability of our network to perform a weakly localization of the cell. Firstly, we demonstrate that whilst GANs can learn the mapping between the input domain and the target distribution efficiently, the discriminator network is not able to detect the regions of interest. Secondly, we present a novel attention transfer mechanism which allows us to enforce the discriminator to put emphasis on the regions of interest via transfer learning. Thirdly, we show that this leads to more realistic images, as the discriminator learns to put emphasis on the area of interest. Fourthly, the proposed method allows one to generate both images as well as attention maps which can be useful for data annotation e.g in object detection. Recent advancements in generative adversarial networks (GANs), using deep convolutional models, have supported the development of image generation techniques able to reach satisfactory levels of realism. Further improvements have been proposed to condition GANs to generate images matching a specific object category or a short text description. In this work, we build on the latter class of approaches and investigate the possibility of driving and conditioning the image generation process by means of brain signals recorded, through an electroencephalograph (EEG), while users look at images from a set of 40 ImageNet object categories with the objective of generating the seen images. To accomplish this task, we first demonstrate that brain activity EEG signals encode visually-related information that allows us to accurately discriminate between visual object categories and, accordingly, we extract a more compact class-dependent representation of EEG data using recurrent neural networks. Afterwards, we use the learned EEG manifold to condition image generation employing GANs, which, during inference, will read EEG signals and convert them into images. We tested our generative approach using EEG signals recorded from six subjects while looking at images of the aforementioned 40 visual classes. The results show that for classes represented by well-defined visual patterns (e.g., pandas, airplane, etc.), the generated images are realistic and highly resemble those evoking the EEG signals used for conditioning GANs, resulting in an actual reading-the-mind process. Generative adversarial networks (GANs) have recently been adopted to single image super-resolution (SISR) and showed impressive results with realistically synthesized high-frequency textures. However, the results of such GAN-based approaches tend to include less meaningful high-frequency noise that is irrelevant to the input image. In this paper, we propose a novel GAN-based SISR method that overcomes the limitation and produces more realistic results by attaching an additional discriminator that works in the feature domain. Our additional discriminator encourages the generator to produce structural high-frequency features rather than noisy artifacts as it distinguishes synthetic and real images in terms of features. We also design a new generator that utilizes long-range skip connections so that information between distant layers can be transferred more effectively. Experiments show that our method achieves the state-of-the-art performance in terms of both PSNR and perceptual quality compared to recent GAN-based methods. Although Generative Adversarial Networks (GANs) have shown remarkable success in various tasks, they still face challenges in generating high quality images. In this paper, we propose Stacked Generative Adversarial Networks (StackGANs) aimed at generating high-resolution photo-realistic images. First, we propose a two-stage generative adversarial network architecture, StackGAN-v1, for text-to-image synthesis. The Stage-I GAN sketches the primitive shape and colors of a scene based on a given text description, yielding low-resolution images. The Stage-II GAN takes Stage-I results and the text description as inputs, and generates high-resolution images with photo-realistic details. Second, an advanced multi-stage generative adversarial network architecture, StackGAN-v2, is proposed for both conditional and unconditional generative tasks. Our StackGAN-v2 consists of multiple generators and multiple discriminators arranged in a tree-like structure; images at multiple scales corresponding to the same scene are generated from different branches of the tree. StackGAN-v2 shows more stable training behavior than StackGAN-v1 by jointly approximating multiple distributions. Extensive experiments demonstrate that the proposed stacked generative adversarial networks significantly outperform other state-of-the-art methods in generating photo-realistic images. Abstract Generative adversarial networks have gained a lot of attention in the computer vision community due to their capability of data generation without explicitly modelling the probability density function. The adversarial loss brought by the discriminator provides a clever way of incorporating unlabeled samples into training and imposing higher order consistency. This has proven to be useful in many cases, such as domain adaptation, data augmentation, and image-to-image translation. These properties have attracted researchers in the medical imaging community, and we have seen rapid adoption in many traditional and novel applications, such as image reconstruction, segmentation, detection, classification, and cross-modality synthesis. Based on our observations, this trend will continue and we therefore conducted a review of recent advances in medical imaging using the adversarial training scheme with the hope of benefiting researchers interested in this technique. Generative Adversarial Networks (GANs) have recently demonstrated the capability to synthesize compelling real-world images, such as room interiors, album covers, manga, faces, birds, and flowers. While existing models can synthesize images based on global constraints such as a class label or caption, they do not provide control over pose or object location. We propose a new model, the Generative Adversarial What-Where Network (GAWWN), that synthesizes images given instructions describing what content to draw in which location. We show high-quality 128 × 128 image synthesis on the Caltech-UCSD Birds dataset, conditioned on both informal text descriptions and also object location. Our system exposes control over both the bounding box around the bird and its constituent parts. By modeling the conditional distributions over part locations, our system also enables conditioning on arbitrary subsets of parts (e.g. only the beak and tail), yielding an efficient interface for picking part locations. Medical datasets are often highly imbalanced, over representing common medical problems, and sparsely representing rare problems. We propose simulation of pathology in images to overcome the above limitations. Using chest Xrays as a model medical image, we implement a generative adversarial network (GAN) to create artificial images based upon a modest sized labeled dataset. We employ a combination of real and artificial images to train a deep convolutional neural network (DCNN) to detect pathology across five classes of disease. We furthermore demonstrate that augmenting the original imbalanced dataset with GAN generated images improves performance of chest pathology classification using the proposed DCNN in comparison to the same DCNN trained with the original dataset alone. This improved performance is largely attributed to balancing of the dataset using GAN generated images, where image classes that are lacking in example images are preferentially augmented. A Triangle Generative Adversarial Network ( @math -GAN) is developed for semi-supervised cross-domain joint distribution matching, where the training data consists of samples from each domain, and supervision of domain correspondence is provided by only a few paired samples. @math -GAN consists of four neural networks, two generators and two discriminators. The generators are designed to learn the two-way conditional distributions between the two domains, while the discriminators implicitly define a ternary discriminative function, which is trained to distinguish real data pairs and two kinds of fake data pairs. The generators and discriminators are trained together using adversarial learning. Under mild assumptions, in theory the joint distributions characterized by the two generators concentrate to the data distribution. In experiments, three different kinds of domain pairs are considered, image-label, image-image and image-attribute pairs. Experiments on semi-supervised image classification, image-to-image translation and attribute-based image generation demonstrate the superiority of the proposed approach. A Triangle Generative Adversarial Network ( @math -GAN) is developed for semi-supervised cross-domain joint distribution matching, where the training data consists of samples from each domain, and supervision of domain correspondence is provided by only a few paired samples. @math -GAN consists of four neural networks, two generators and two discriminators. The generators are designed to learn the two-way conditional distributions between the two domains, while the discriminators implicitly define a ternary discriminative function, which is trained to distinguish real data pairs and two kinds of fake data pairs. The generators and discriminators are trained together using adversarial learning. Under mild assumptions, in theory the joint distributions characterized by the two generators concentrate to the data distribution. In experiments, three different kinds of domain pairs are considered, image-label, image-image and image-attribute pairs. Experiments on semi-supervised image classification, image-to-image translation and attribute-based image generation demonstrate the superiority of the proposed approach.