Convolutional networks (ConvNets) have achieved great successes in various challenging vision tasks. However, the performance of ConvNets would degrade when encountering the domain shift. The domain adaptation is more significant while challenging in the field of biomedical image analysis, where cross-modality data have largely different distributions. Given that annotating the medical data is especially expensive, the supervised transfer learning approaches are not quite optimal. In this paper, we propose an unsupervised domain adaptation framework with adversarial learning for cross-modality biomedical image segmentations. Specifically, our model is based on a dilated fully convolutional network for pixel-wise prediction. Moreover, we build a plug-and-play domain adaptation module (DAM) to map the target input to features which are aligned with source domain feature space. A domain critic module (DCM) is set up for discriminating the feature space of both domains. We optimize the DAM and DCM via an adversarial loss without using any target domain label. Our proposed method is validated by adapting a ConvNet trained with MRI images to unpaired CT data for cardiac structures segmentations, and achieved very promising results.
Most prior studies on unsupervised domain adaptation focused on aligning the distributions between domains in feature space, by minimizing measures of distance between features extracted from the source and target domains. For example, the Maximum Mean Discrepancy (MMD) was minimized together with a task-specific loss to learn the domain-invariant and semantic-meaningful features in @cite_9 . The correlations of layer activations between the domains were aligned in the study of @cite_21 . Based on this, @cite_0 further extended the work and minimized domain difference based on both the first and second order information between source and target domains. Alternatively, with the emergence of generative adversarial network (GAN) @cite_11 and its powerful extensions @cite_17 @cite_18 , the mapping between domains were implicitly learned via the adversarial loss. The @cite_13 proposed to extract domain-invariant features by sharing weights between two ConvNet classifiers. Later, the @cite_3 introduced a more flexible adversarial learning method with untied weight sharing, which helps effective learning in the presence of larger domain shifts. Another GAN based direction of solution is to learn a transformation in the pixel space @cite_12 , adapting the source-domain images to appear as if drawn from the target domain.
@cite_18 @cite_11 @cite_9 @cite_21 @cite_3 @cite_0 @cite_13 @cite_12 @cite_17
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Unsupervised domain adaptation aims to mitigate the domain shift when transferring knowledge from a supervised source domain to an unsupervised target domain. Adversarial Feature Alignment has been successfully explored to minimize the domain discrepancy. However, existing methods are usually struggling to optimize mixed learning objectives and vulnerable to negative transfer when two domains do not share the identical label space. In this paper, we empirically reveal that the erratic discrimination of target domain mainly reflects in its much lower feature norm value with respect to that of the source domain. We present a non-parametric Adaptive Feature Norm AFN approach, which is independent of the association between label spaces of the two domains. We demonstrate that adapting feature norms of source and target domains to achieve equilibrium over a large range of values can result in significant domain transfer gains. Without bells and whistles but a few lines of code, our method largely lifts the discrimination of target domain (23.7 from the Source Only in VisDA2017) and achieves the new state of the art under the vanilla setting. Furthermore, as our approach does not require to deliberately align the feature distributions, it is robust to negative transfer and can outperform the existing approaches under the partial setting by an extremely large margin (9.8 on Office-Home and 14.1 on VisDA2017). Code is available at this https URL. We are responsible for the reproducibility of our method. The effectiveness of generative adversarial approaches in producing images according to a specific style or visual domain has recently opened new directions to solve the unsupervised domain adaptation problem. It has been shown that source labeled images can be modified to mimic target samples making it possible to train directly a classifier in the target domain, despite the original lack of annotated data. Inverse mappings from the target to the source domain have also been evaluated but only passing through adapted feature spaces, thus without new image generation. In this paper we propose to better exploit the potential of generative adversarial networks for adaptation by introducing a novel symmetric mapping among domains. We jointly optimize bi-directional image transformations combining them with target self-labeling. Moreover we define a new class consistency loss that aligns the generators in the two directions imposing to conserve the class identity of an image passing through both domain mappings. A detailed qualitative and quantitative analysis of the reconstructed images confirm the power of our approach. By integrating the two domain specific classifiers obtained with our bi-directional network we exceed previous state-of-the-art unsupervised adaptation results on four different benchmark datasets. Domain adaptation refers to the problem of leveraging labeled data in a source domain to learn an accurate model in a target domain where labels are scarce or unavailable. A recent approach for finding a common representation of the two domains is via domain adversarial training (Ganin & Lempitsky, 2015), which attempts to induce a feature extractor that matches the source and target feature distributions in some feature space. However, domain adversarial training faces two critical limitations: 1) if the feature extraction function has high-capacity, then feature distribution matching is a weak constraint, 2) in non-conservative domain adaptation (where no single classifier can perform well in both the source and target domains), training the model to do well on the source domain hurts performance on the target domain. In this paper, we address these issues through the lens of the cluster assumption, i.e., decision boundaries should not cross high-density data regions. We propose two novel and related models: 1) the Virtual Adversarial Domain Adaptation (VADA) model, which combines domain adversarial training with a penalty term that punishes the violation the cluster assumption; 2) the Decision-boundary Iterative Refinement Training with a Teacher (DIRT-T) model, which takes the VADA model as initialization and employs natural gradient steps to further minimize the cluster assumption violation. Extensive empirical results demonstrate that the combination of these two models significantly improve the state-of-the-art performance on several visual domain adaptation benchmarks. In this paper, we propose a new unsupervised domain adaptation approach called Collaborative and Adversarial Network (CAN) through domain-collaborative and domain-adversarial training of neural networks. We add several domain classifiers on multiple CNN feature extraction blocks1, in which each domain classifier is connected to the hidden representations from one block and one loss function is defined based on the hidden presentation and the domain labels (e.g., source and target). We design a new loss function by integrating the losses from all blocks in order to learn domain informative representations from lower blocks through collaborative learning and learn domain uninformative representations from higher blocks through adversarial learning. We further extend our CAN method as Incremental CAN (iCAN), in which we iteratively select a set of pseudo-labelled target samples based on the image classifier and the last domain classifier from the previous training epoch and re-train our CAN model by using the enlarged training set. Comprehensive experiments on two benchmark datasets Office and ImageCLEF-DA clearly demonstrate the effectiveness of our newly proposed approaches CAN and iCAN for unsupervised domain adaptation. Convolutional networks (ConvNets) have achieved great successes in various challenging vision tasks. However, the performance of ConvNets would degrade when encountering the domain shift. The domain adaptation is more significant while challenging in the field of biomedical image analysis, where cross-modality data have largely different distributions. Given that annotating the medical data is especially expensive, the supervised transfer learning approaches are not quite optimal. In this paper, we propose an unsupervised domain adaptation framework with adversarial learning for cross-modality biomedical image segmentations. Specifically, our model is based on a dilated fully convolutional network for pixel-wise prediction. Moreover, we build a plug-and-play domain adaptation module (DAM) to map the target input to features which are aligned with source domain feature space. A domain critic module (DCM) is set up for discriminating the feature space of both domains. We optimize the DAM and DCM via an adversarial loss without using any target domain label. Our proposed method is validated by adapting a ConvNet trained with MRI images to unpaired CT data for cardiac structures segmentations, and achieved very promising results. In this work, we present a method for unsupervised domain adaptation. Many adversarial learning methods train domain classifier networks to distinguish the features as either a source or target and train a feature generator network to mimic the discriminator. Two problems exist with these methods. First, the domain classifier only tries to distinguish the features as a source or target and thus does not consider task-specific decision boundaries between classes. Therefore, a trained generator can generate ambiguous features near class boundaries. Second, these methods aim to completely match the feature distributions between different domains, which is difficult because of each domain's characteristics. To solve these problems, we introduce a new approach that attempts to align distributions of source and target by utilizing the task-specific decision boundaries. We propose to maximize the discrepancy between two classifiers' outputs to detect target samples that are far from the support of the source. A feature generator learns to generate target features near the support to minimize the discrepancy. Our method outperforms other methods on several datasets of image classification and semantic segmentation. The codes are available at https: github.com mil-tokyo MCD_DA In spite of the compelling achievements that deep neural networks (DNNs) have made in medical image computing, these deep models often suffer from degraded performance when being applied to new test datasets with domain shift. In this paper, we present a novel unsupervised domain adaptation approach for segmentation tasks by designing semantic-aware generative adversarial networks (GANs). Specifically, we transform the test image into the appearance of source domain, with the semantic structural information being well preserved, which is achieved by imposing a nested adversarial learning in semantic label space. In this way, the segmentation DNN learned from the source domain is able to be directly generalized to the transformed test image, eliminating the need of training a new model for every new target dataset. Our domain adaptation procedure is unsupervised, without using any target domain labels. The adversarial learning of our network is guided by a GAN loss for mapping data distributions, a cycle-consistency loss for retaining pixel-level content, and a semantic-aware loss for enhancing structural information. We validated our method on two different chest X-ray public datasets for left right lung segmentation. Experimental results show that the segmentation performance of our unsupervised approach is highly competitive with the upper bound of supervised transfer learning. In multimedia analysis, the task of domain adaptation is to adapt the feature representation learned in the source domain with rich label information to the target domain with less or even no label information. Significant research endeavors have been devoted to aligning the feature distributions between the source and the target domains in the top fully connected layers based on unsupervised DNN-based models. However, the domain adaptation has been arbitrarily constrained near the output ends of the DNN models, which thus brings about inadequate knowledge transfer in DNN-based domain adaptation process, especially near the input end. We develop an attention transfer process for convolutional domain adaptation. The domain discrepancy, measured in correlation alignment loss, is minimized on the second-order correlation statistics of the attention maps for both source and target domains. Then we propose Deep Unsupervised Convolutional Domain Adaptation DUCDA method, which jointly minimizes the supervised classification loss of labeled source data and the unsupervised correlation alignment loss measured on both convolutional layers and fully connected layers. The multi-layer domain adaptation process collaborately reinforces each individual domain adaptation component, and significantly enhances the generalization ability of the CNN models. Extensive cross-domain object classification experiments show DUCDA outperforms other state-of-the-art approaches, and validate the promising power of DUCDA towards large scale real world application. This paper proposes an importance weighted adversarial nets-based method for unsupervised domain adaptation, specific for partial domain adaptation where the target domain has less number of classes compared to the source domain. Previous domain adaptation methods generally assume the identical label spaces, such that reducing the distribution divergence leads to feasible knowledge transfer. However, such an assumption is no longer valid in a more realistic scenario that requires adaptation from a larger and more diverse source domain to a smaller target domain with less number of classes. This paper extends the adversarial nets-based domain adaptation and proposes a novel adversarial nets-based partial domain adaptation method to identify the source samples that are potentially from the outlier classes and, at the same time, reduce the shift of shared classes between domains. This paper proposes an importance weighted adversarial nets-based method for unsupervised domain adaptation, specific for partial domain adaptation where the target domain has less number of classes compared to the source domain. Previous domain adaptation methods generally assume the identical label spaces, such that reducing the distribution divergence leads to feasible knowledge transfer. However, such an assumption is no longer valid in a more realistic scenario that requires adaptation from a larger and more diverse source domain to a smaller target domain with less number of classes. This paper extends the adversarial nets-based domain adaptation and proposes a novel adversarial nets-based partial domain adaptation method to identify the source samples that are potentially from the outlier classes and, at the same time, reduce the shift of shared classes between domains. While domain adaptation has been actively researched in recent years, most theoretical results and algorithms focus on the single-source-single-target adaptation setting. Naive application of such algorithms on multiple source domain adaptation problem may lead to suboptimal solutions. We propose a new generalization bound for domain adaptation when there are multiple source domains with labeled instances and one target domain with unlabeled instances. Compared with existing bounds, the new bound does not require expert knowledge about the target distribution, nor the optimal combination rule for multisource domains. Interestingly, our theory also leads to an efficient learning strategy using adversarial neural networks: we show how to interpret it as learning feature representations that are invariant to the multiple domain shifts while still being discriminative for the learning task. To this end, we propose two models, both of which we call multisource domain adversarial networks (MDANs): the first model optimizes directly our bound, while the second model is a smoothed approximation of the first one, leading to a more data-efficient and task-adaptive model. The optimization tasks of both models are minimax saddle point problems that can be optimized by adversarial training. To demonstrate the effectiveness of MDANs, we conduct extensive experiments showing superior adaptation performance on three real-world datasets: sentiment analysis, digit classification, and vehicle counting. We present a method for transferring neural representations from label-rich source domains to unlabeled target domains. Recent adversarial methods proposed for this task learn to align features across domains by fooling a special domain critic network. However, a drawback of this approach is that the critic simply labels the generated features as in-domain or not, without considering the boundaries between classes. This can lead to ambiguous features being generated near class boundaries, reducing target classification accuracy. We propose a novel approach, Adversarial Dropout Regularization (ADR), to encourage the generator to output more discriminative features for the target domain. Our key idea is to replace the critic with one that detects non-discriminative features, using dropout on the classifier network. The generator then learns to avoid these areas of the feature space and thus creates better features. We apply our ADR approach to the problem of unsupervised domain adaptation for image classification and semantic segmentation tasks, and demonstrate significant improvement over the state of the art. We also show that our approach can be used to train Generative Adversarial Networks for semi-supervised learning. We present a method for transferring neural representations from label-rich source domains to unlabeled target domains. Recent adversarial methods proposed for this task learn to align features across domains by fooling a special domain critic network. However, a drawback of this approach is that the critic simply labels the generated features as in-domain or not, without considering the boundaries between classes. This can lead to ambiguous features being generated near class boundaries, reducing target classification accuracy. We propose a novel approach, Adversarial Dropout Regularization (ADR), to encourage the generator to output more discriminative features for the target domain. Our key idea is to replace the critic with one that detects non-discriminative features, using dropout on the classifier network. The generator then learns to avoid these areas of the feature space and thus creates better features. We apply our ADR approach to the problem of unsupervised domain adaptation for image classification and semantic segmentation tasks, and demonstrate significant improvement over the state of the art. We also show that our approach can be used to train Generative Adversarial Networks for semi-supervised learning. Adversarial learning methods are a promising approach to training robust deep networks, and can generate complex samples across diverse domains. They can also improve recognition despite the presence of domain shift or dataset bias: recent adversarial approaches to unsupervised domain adaptation reduce the difference between the training and test domain distributions and thus improve generalization performance. However, while generative adversarial networks (GANs) show compelling visualizations, they are not optimal on discriminative tasks and can be limited to smaller shifts. On the other hand, discriminative approaches can handle larger domain shifts, but impose tied weights on the model and do not exploit a GAN-based loss. In this work, we first outline a novel generalized framework for adversarial adaptation, which subsumes recent state-of-the-art approaches as special cases, and use this generalized view to better relate prior approaches. We then propose a previously unexplored instance of our general framework which combines discriminative modeling, untied weight sharing, and a GAN loss, which we call Adversarial Discriminative Domain Adaptation (ADDA). We show that ADDA is more effective yet considerably simpler than competing domain-adversarial methods, and demonstrate the promise of our approach by exceeding state-of-the-art unsupervised adaptation results on standard domain adaptation tasks as well as a difficult cross-modality object classification task. In domain adaptation, maximum mean discrepancy (MMD) has been widely adopted as a discrepancy metric between the distributions of source and target domains. However, existing MMD-based domain adaptation methods generally ignore the changes of class prior distributions, i.e., class weight bias across domains. This remains an open problem but ubiquitous for domain adaptation, which can be caused by changes in sample selection criteria and application scenarios. We show that MMD cannot account for class weight bias and results in degraded domain adaptation performance. To address this issue, a weighted MMD model is proposed in this paper. Specifically, we introduce class-specific auxiliary weights into the original MMD for exploiting the class prior probability on source and target domains, whose challenge lies in the fact that the class label in target domain is unavailable. To account for it, our proposed weighted MMD model is defined by introducing an auxiliary weight for each class in the source domain, and a classification EM algorithm is suggested by alternating between assigning the pseudo-labels, estimating auxiliary weights and updating model parameters. Extensive experiments demonstrate the superiority of our weighted MMD over conventional MMD for domain adaptation. In domain adaptation, maximum mean discrepancy (MMD) has been widely adopted as a discrepancy metric between the distributions of source and target domains. However, existing MMD-based domain adaptation methods generally ignore the changes of class prior distributions, i.e., class weight bias across domains. This remains an open problem but ubiquitous for domain adaptation, which can be caused by changes in sample selection criteria and application scenarios. We show that MMD cannot account for class weight bias and results in degraded domain adaptation performance. To address this issue, a weighted MMD model is proposed in this paper. Specifically, we introduce class-specific auxiliary weights into the original MMD for exploiting the class prior probability on source and target domains, whose challenge lies in the fact that the class label in target domain is unavailable. To account for it, our proposed weighted MMD model is defined by introducing an auxiliary weight for each class in the source domain, and a classification EM algorithm is suggested by alternating between assigning the pseudo-labels, estimating auxiliary weights and updating model parameters. Extensive experiments demonstrate the superiority of our weighted MMD over conventional MMD for domain adaptation. We present an adversarial domain adaptation based deep learning approach for automatic tumor segmentation from T2-weighted MRI. Our approach is composed of two steps: (i) a tumor-aware unsupervised cross-domain adaptation (CT to MRI), followed by (ii) semi-supervised tumor segmentation using Unet trained with synthesized and limited number of original MRIs. We introduced a novel target specific loss, called tumor-aware loss, for unsupervised cross-domain adaptation that helps to preserve tumors on synthesized MRIs produced from CT images. In comparison, state-of-the art adversarial networks trained without our tumor-aware loss produced MRIs with ill-preserved or missing tumors. All networks were trained using labeled CT images from 377 patients with non-small cell lung cancer obtained from the Cancer Imaging Archive and unlabeled T2w MRIs from a completely unrelated cohort of 6 patients with pre-treatment and 36 on-treatment scans. Next, we combined 6 labeled pre-treatment MRI scans with the synthesized MRIs to boost tumor segmentation accuracy through semi-supervised learning. Semi-supervised training of cycle-GAN produced a segmentation accuracy of 0.66 computed using Dice Score Coefficient (DSC). Our method trained with only synthesized MRIs produced an accuracy of 0.74 while the same method trained in semi-supervised setting produced the best accuracy of 0.80 on test. Our results show that tumor-aware adversarial domain adaptation helps to achieve reasonably accurate cancer segmentation from limited MRI data by leveraging large CT datasets. Unsupervised Domain Adaptation (UDA) aims to transfer domain knowledge from existing well-defined tasks to new ones where labels are unavailable. In the real-world applications, as the domain (task) discrepancies are usually uncontrollable, it is significantly motivated to match the feature distributions even if the domain discrepancies are disparate. Additionally, as no label is available in the target domain, how to successfully adapt the classifier from the source to the target domain still remains an open question. In this paper, we propose the Re-weighted Adversarial Adaptation Network (RAAN) to reduce the feature distribution divergence and adapt the classifier when domain discrepancies are disparate. Specifically, to alleviate the need of common supports in matching the feature distribution, we choose to minimize optimal transport (OT) based Earth-Mover (EM) distance and reformulate it to a minimax objective function. Utilizing this, RAAN can be trained in an end-to-end and adversarial manner. To further adapt the classifier, we propose to match the label distribution and embed it into the adversarial training. Finally, after extensive evaluation of our method using UDA datasets of varying difficulty, RAAN achieved the state-of-the-art results and outperformed other methods by a large margin when the domain shifts are disparate. Adversarial learning methods are a promising approach to training robust deep networks, and can generate complex samples across diverse domains. They also can improve recognition despite the presence of domain shift or dataset bias: several adversarial approaches to unsupervised domain adaptation have recently been introduced, which reduce the difference between the training and test domain distributions and thus improve generalization performance. Prior generative approaches show compelling visualizations, but are not optimal on discriminative tasks and can be limited to smaller shifts. Prior discriminative approaches could handle larger domain shifts, but imposed tied weights on the model and did not exploit a GAN-based loss. We first outline a novel generalized framework for adversarial adaptation, which subsumes recent state-of-the-art approaches as special cases, and we use this generalized view to better relate the prior approaches. We propose a previously unexplored instance of our general framework which combines discriminative modeling, untied weight sharing, and a GAN loss, which we call Adversarial Discriminative Domain Adaptation (ADDA). We show that ADDA is more effective yet considerably simpler than competing domain-adversarial methods, and demonstrate the promise of our approach by exceeding state-of-the-art unsupervised adaptation results on standard cross-domain digit classification tasks and a new more difficult cross-modality object classification task. Transferring the knowledge of pretrained networks to new domains by means of finetuning is a widely used practice for applications based on discriminative models. To the best of our knowledge this practice has not been studied within the context of generative deep networks. Therefore, we study domain adaptation applied to image generation with generative adversarial networks. We evaluate several aspects of domain adaptation, including the impact of target domain size, the relative distance between source and target domain, and the initialization of conditional GANs. Our results show that using knowledge from pretrained networks can shorten the convergence time and can significantly improve the quality of the generated images, especially when the target data is limited. We show that these conclusions can also be drawn for conditional GANs even when the pretrained model was trained without conditioning. Our results also suggest that density may be more important than diversity and a dataset with one or few densely sampled classes may be a better source model than more diverse datasets such as ImageNet or Places.