The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods. In this paper, we propose MDNet to establish a direct multimodal mapping between medical images and diagnostic reports that can read images, generate diagnostic reports, retrieve images by symptom descriptions, and visualize attention, to provide justifications of the network diagnosis process. MDNet includes an image model and a language model. The image model is proposed to enhance multi-scale feature ensembles and utilization efficiency. The language model, integrated with our improved attention mechanism, aims to read and explore discriminative image feature descriptions from reports to learn a direct mapping from sentence words to image pixels. The overall network is trained end-to-end by using our developed optimization strategy. Based on a pathology bladder cancer images and its diagnostic reports (BCIDR) dataset, we conduct sufficient experiments to demonstrate that MDNet outperforms comparative baselines. The proposed image model obtains state-of-the-art performance on two CIFAR datasets as well.
Image-sentence alignment also encourages visual explanations for network inner workings @cite_14 . Hence, attention mechanisms become particularly necessary @cite_35 . We witness growing interests of its exploration to achieve the network interpretability @cite_37 @cite_11 . The full power of this field has vast potentials to renovate computer-aided medical diagnosis, but a dearth of related work exists. To date, @cite_32 and @cite_2 deal with the problem of generating disease keywords for radiology images.
@cite_35 @cite_37 @cite_14 @cite_32 @cite_2 @cite_11
2139054399 2735683533 2963409068 2592048188 2963075078 2963849887 2481240925 2048343491 1905882502 2951805548 2950012948 2044626341 2950616067 2963882743 2886327376 111468195 2950489286 2560476520 2883311563 125575914
Communication of follow-up recommendations when abnormalities are identified on imaging studies is prone to error. The absence of an automated system to identify and track radiology recommendations is an important barrier to ensuring timely follow-up of patients especially with non-acute incidental findings on imaging examinations. In this paper, we present a text processing pipeline to automatically identify clinically important recommendation sentences in radiology reports. Our extraction pipeline is based on natural language processing (NLP) and supervised text classification methods. To develop and test the pipeline, we created a corpus of 800 radiology reports double annotated for recommendation sentences by a radiologist and an internist. We ran several experiments to measure the impact of different feature types and the data imbalance between positive and negative recommendation sentences. Our fully statistical approach achieved the best f-score 0.758 in identifying the critical recommendation sentences in radiology reports. The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods. In this paper, we propose MDNet to establish a direct multimodal mapping between medical images and diagnostic reports that can read images, generate diagnostic reports, retrieve images by symptom descriptions, and visualize attention, to provide justifications of the network diagnosis process. MDNet includes an image model and a language model. The image model is proposed to enhance multi-scale feature ensembles and utilization efficiency. The language model, integrated with our improved attention mechanism, aims to read and explore discriminative image feature descriptions from reports to learn a direct mapping from sentence words to image pixels. The overall network is trained end-to-end by using our developed optimization strategy. Based on a pathology bladder cancer images and its diagnostic reports (BCIDR) dataset, we conduct sufficient experiments to demonstrate that MDNet outperforms comparative baselines. The proposed image model obtains state-of-the-art performance on two CIFAR datasets as well. The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods. In this paper, we propose MDNet to establish a direct multimodal mapping between medical images and diagnostic reports that can read images, generate diagnostic reports, retrieve images by symptom descriptions, and visualize attention, to provide justifications of the network diagnosis process. MDNet includes an image model and a language model. The image model is proposed to enhance multi-scale feature ensembles and utilization efficiency. The language model, integrated with our improved attention mechanism, aims to read and explore discriminative image feature descriptions from reports to learn a direct mapping from sentence words to image pixels. The overall network is trained end-to-end by using our developed optimization strategy. Based on a pathology bladder cancer images and its diagnostic reports (BCIDR) dataset, we conduct sufficient experiments to demonstrate that MDNet outperforms comparative baselines. The proposed image model obtains state-of-the-art performance on two CIFAR datasets as well. Increasing use of CT in modern medical practice has raised concerns over associated radiation dose. Reduction of radiation dose associated with CT can increase noise and artifacts, which can adversely affect diagnostic confidence. Denoising of low-dose CT images on the other hand can help improve diagnostic confidence, which however is a challenging problem due to its ill-posed nature, since one noisy image patch may correspond to many different output patches. In the past decade, machine learning based approaches have made quite impressive progress in this direction. However, most of those methods, including the recently popularized deep learning techniques, aim for minimizing mean-squared-error (MSE) between a denoised CT image and the ground truth, which results in losing important structural details due to over-smoothing, although the PSNR based performance measure looks great. In this work, we introduce a new perceptual similarity measure as the objective function for a deep convolutional neural network to facilitate CT image denoising. Instead of directly computing MSE for pixel-to-pixel intensity loss, we compare the perceptual features of a denoised output against those of the ground truth in a feature space. Therefore, our proposed method is capable of not only reducing the image noise levels, but also keeping the critical structural information at the same time. Promising results have been obtained in our experiments with a large number of CT images. In this paper, we introduce the semantic knowledge of medical images from their diagnostic reports to provide an inspirational network training and an interpretable prediction mechanism with our proposed novel multimodal neural network, namely TandemNet. Inside TandemNet, a language model is used to represent report text, which cooperates with the image model in a tandem scheme. We propose a novel dual-attention model that facilitates high-level interactions between visual and semantic information and effectively distills useful features for prediction. In the testing stage, TandemNet can make accurate image prediction with an optional report text input. It also interprets its prediction by producing attention on the image and text informative feature pieces, and further generating diagnostic report paragraphs. Based on a pathological bladder cancer images and their diagnostic reports (BCIDR) dataset, sufficient experiments demonstrate that our method effectively learns and integrates knowledge from multimodalities and obtains significantly improved performance than comparing baselines. Abstract With the novel and fast advances in the area of deep neural networks, several challenging image-based tasks have been recently approached by researchers in pattern recognition and computer vision. In this paper, we address one of these tasks, which is to match image content with natural language descriptions, sometimes referred as multimodal content retrieval. Such a task is particularly challenging considering that we must find a semantic correspondence between captions and the respective image, a challenge for both computer vision and natural language processing areas. For such, we propose a novel multimodal approach based solely on convolutional neural networks for aligning images with their captions by directly convolving raw characters. Our proposed character-based textual embeddings allow the replacement of both word-embeddings and recurrent neural networks for text understanding, saving processing time and requiring fewer learnable parameters. Our method is based on the idea of projecting both visual and textual information into a common embedding space. For training such embeddings we optimize a contrastive loss function that is computed to minimize order-violations between images and their respective descriptions. We achieve state-of-the-art performance in the most well-known image-text alignment datasets, namely Microsoft COCO, Flickr8k, and Flickr30k, with a method that is conceptually much simpler and that possesses considerably fewer parameters than current approaches. We present a model that generates natural language descriptions of images and their regions. Our approach leverages datasets of images and their sentence descriptions to learn about the inter-modal correspondences between language and visual data. Our alignment model is based on a novel combination of Convolutional Neural Networks over image regions, bidirectional Recurrent Neural Networks (RNN) over sentences, and a structured objective that aligns the two modalities through a multimodal embedding. We then describe a Multimodal Recurrent Neural Network architecture that uses the inferred alignments to learn to generate novel descriptions of image regions. We demonstrate that our alignment model produces state of the art results in retrieval experiments on Flickr8K, Flickr30K and MSCOCO datasets. We then show that the generated descriptions outperform retrieval baselines on both full images and on a new dataset of region-level annotations. Finally, we conduct large-scale analysis of our RNN language model on the Visual Genome dataset of 4.1 million captions and highlight the differences between image and region-level caption statistics. In this paper we exploit natural sentential descriptions of RGB-D scenes in order to improve 3D semantic parsing. Importantly, in doing so, we reason about which particular object each noun pronoun is referring to in the image. This allows us to utilize visual information in order to disambiguate the so-called coreference resolution problem that arises in text. Towards this goal, we propose a structure prediction model that exploits potentials computed from text and RGB-D imagery to reason about the class of the 3D objects, the scene type, as well as to align the nouns pronouns with the referred visual objects. We demonstrate the effectiveness of our approach on the challenging NYU-RGBD v2 dataset, which we enrich with natural lingual descriptions. We show that our approach significantly improves 3D detection and scene classification accuracy, and is able to reliably estimate the text-to-image alignment. Furthermore, by using textual and visual information, we are also able to successfully deal with coreference in text, improving upon the state-of-the-art Stanford coreference system [15]. We present a model that generates natural language descriptions of images and their regions. Our approach leverages datasets of images and their sentence descriptions to learn about the inter-modal correspondences between language and visual data. Our alignment model is based on a novel combination of Convolutional Neural Networks over image regions, bidirectional Recurrent Neural Networks over sentences, and a structured objective that aligns the two modalities through a multimodal embedding. We then describe a Multimodal Recurrent Neural Network architecture that uses the inferred alignments to learn to generate novel descriptions of image regions. We demonstrate that our alignment model produces state of the art results in retrieval experiments on Flickr8K, Flickr30K and MSCOCO datasets. We then show that the generated descriptions significantly outperform retrieval baselines on both full images and on a new dataset of region-level annotations. We present a model that generates natural language descriptions of images and their regions. Our approach leverages datasets of images and their sentence descriptions to learn about the inter-modal correspondences between language and visual data. Our alignment model is based on a novel combination of Convolutional Neural Networks over image regions, bidirectional Recurrent Neural Networks over sentences, and a structured objective that aligns the two modalities through a multimodal embedding. We then describe a Multimodal Recurrent Neural Network architecture that uses the inferred alignments to learn to generate novel descriptions of image regions. We demonstrate that our alignment model produces state of the art results in retrieval experiments on Flickr8K, Flickr30K and MSCOCO datasets. We then show that the generated descriptions significantly outperform retrieval baselines on both full images and on a new dataset of region-level annotations. In this paper, we propose multimodal convolutional neural networks (m-CNNs) for matching image and sentence. Our m-CNN provides an end-to-end framework with convolutional architectures to exploit image representation, word composition, and the matching relations between the two modalities. More specifically, it consists of one image CNN encoding the image content, and one matching CNN learning the joint representation of image and sentence. The matching CNN composes words to different semantic fragments and learns the inter-modal relations between image and the composed fragments at different levels, thus fully exploit the matching relations between image and sentence. Experimental results on benchmark databases of bidirectional image and sentence retrieval demonstrate that the proposed m-CNNs can effectively capture the information necessary for image and sentence matching. Specifically, our proposed m-CNNs for bidirectional image and sentence retrieval on Flickr30K and Microsoft COCO databases achieve the state-of-the-art performances. Building bilateral semantic associations between images and texts is among the fundamental problems in computer vision. In this paper, we study two complementary cross-modal prediction tasks: (i) predicting text(s) given an image (“Im2Text”), and (ii) predicting image(s) given a piece of text (“Text2Im”). We make no assumption on the specific form of text; i.e., it could be either a set of labels, phrases, or even captions. We pose both these tasks in a retrieval framework. For Im2Text, given a query image, our goal is to retrieve a ranked list of semantically relevant texts from an independent textcorpus (i.e., texts with no corresponding images). Similarly, for Text2Im, given a query text, we aim to retrieve a ranked list of semantically relevant images from a collection of unannotated images (i.e., images without any associated textual meta-data). We propose a novel Structural SVM based unified formulation for these two tasks. For both visual and textual data, two types of representations are investigated. These are based on: (1) unimodal probability distributions over topics learned using latent Dirichlet allocation, and (2) explicitly learned multi-modal correlations using canonical correlation analysis. Extensive experiments on three popular datasets (two medium and one web-scale) demonstrate that our framework gives promising results compared to existing models under various settings, thus confirming its efficacy for both the tasks. Image-language matching tasks have recently attracted a lot of attention in the computer vision field. These tasks include image-sentence matching, i.e., given an image query, retrieving relevant sentences and vice versa, and region-phrase matching or visual grounding, i.e., matching a phrase to relevant regions. This paper investigates two-branch neural networks for learning the similarity between these two data modalities. We propose two network structures that produce different output representations. The first one, referred to as an embedding network, learns an explicit shared latent embedding space with a maximum-margin ranking loss and novel neighborhood constraints. Compared to standard triplet sampling, we perform improved neighborhood sampling that takes neighborhood information into consideration while constructing mini-batches. The second network structure, referred to as a similarity network, fuses the two branches via element-wise product and is trained with regression loss to directly predict a similarity score. Extensive experiments show that our networks achieve high accuracies for phrase localization on the Flickr30K Entities dataset and for bi-directional image-sentence retrieval on Flickr30K and MSCOCO datasets. Textual-visual matching aims at measuring similarities between sentence descriptions and images. Most existing methods tackle this problem without effectively utilizing identity-level annotations. In this paper, we propose an identity-aware two-stage framework for the textual-visual matching problem. Our stage-1 CNN-LSTM network learns to embed cross-modal features with a novel Cross-Modal Cross-Entropy (CMCE) loss. The stage-1 network is able to efficiently screen easy incorrect matchings and also provide initial training point for the stage-2 training. The stage-2 CNN-LSTM network refines the matching results with a latent co-attention mechanism. The spatial attention relates each word with corresponding image regions while the latent semantic attention aligns different sentence structures to make the matching results more robust to sentence structure variations. Extensive experiments on three datasets with identity-level annotations show that our framework outperforms state-of-the-art approaches by large margins. In this work, we exploit the task of joint classification and weakly supervised localization of thoracic diseases from chest radiographs, with only image-level disease labels coupled with disease severity-level (DSL) information of a subset. A convolutional neural network (CNN) based attention-guided curriculum learning (AGCL) framework is presented, which leverages the severity-level attributes mined from radiology reports. Images in order of difficulty (grouped by different severity-levels) are fed to CNN to boost the learning gradually. In addition, highly confident samples (measured by classification probabilities) and their corresponding class-conditional heatmaps (generated by the CNN) are extracted and further fed into the AGCL framework to guide the learning of more distinctive convolutional features in the next iteration. A two-path network architecture is designed to regress the heatmaps from selected seed samples in addition to the original classification task. The joint learning scheme can improve the classification and localization performance along with more seed samples for the next iteration. We demonstrate the effectiveness of this iterative refinement framework via extensive experimental evaluations on the publicly available ChestXray14 dataset. AGCL achieves over 5.7 (averaged over 14 diseases) increase in classification AUC and 7 11 increases in Recall Precision for the localization task compared to the state of the art. Recent years have seen exciting advances in Computer Assisted Surgery (CAS). CAS systems are currently in use which provide data to the surgeon, provide passive feedback and motion constraint, and even automate parts of the surgery by manipulating cutters and endoscopic cameras. For most of these systems, accurate registration between the patient's anatomy and the CAS system is crucial: if the position of the surgical target is not known with sufficient accuracy, therapies cannot be applied precisely, and treatment efficacy falls. This thesis presents a system for recovering the position and orientation of the target anatomy in 3D space based on iterative comparison of 2D planar radiographs with preoperative CT data. More specifically, this system uses X-ray images acquired at the time of treatment, and iteratively compares them with synthetic images, known as Digitally Reconstructed Radiographs (DRRs), in order to estimate the position and orientation of the target anatomy. An intermediate data representation called a Transgraph is presented. The Transgraph is similar to the Lumigraph, or Light Field, and extends the computer graphics field called image-based rendering to transmission imaging. This representation speeds up computation of DRRs by over an order of magnitude compared to ray-casting techniques, without the use of special graphics hardware. A hardware based volume rendering technique is also presented. This approach is based on new texture mapping techniques which enable DRR generation using off the shelf consumer grade computer graphics hardware. These techniques permit computation of full resolution (512 x 512) DRRs based on 256 x 256 x 256 CT data in roughly 70 ms. The registration system is evaluated for application to frameless stereotactic radiosurgery, and phantom studies are presented demonstrating accuracy comparable to state of the art immobilization systems. Additional phantom studies are presented in which the registration system is used to measure implant orientation following total hip replacement surgery, improving on current practice by a factor of two. Despite the recent advances in automatically describing image contents, their applications have been mostly limited to image caption datasets containing natural images (e.g., Flickr 30k, MSCOCO). In this paper, we present a deep learning model to efficiently detect a disease from an image and annotate its contexts (e.g., location, severity and the affected organs). We employ a publicly available radiology dataset of chest x-rays and their reports, and use its image annotations to mine disease names to train convolutional neural networks (CNNs). In doing so, we adopt various regularization techniques to circumvent the large normal-vs-diseased cases bias. Recurrent neural networks (RNNs) are then trained to describe the contexts of a detected disease, based on the deep CNN features. Moreover, we introduce a novel approach to use the weights of the already trained pair of CNN RNN on the domain-specific image text dataset, to infer the joint image text contexts for composite image labeling. Significantly improved image annotation results are demonstrated using the recurrent neural cascade model by taking the joint image text contexts into account. Early diagnosis of interstitial lung diseases is crucial for their treatment, but even experienced physicians find it difficult, as their clinical manifestations are similar. In order to assist with the diagnosis, computer-aided diagnosis (CAD) systems have been developed. These commonly rely on a fixed scale classifier that scans CT images, recognizes textural lung patterns and generates a map of pathologies. In a previous study, we proposed a method for classifying lung tissue patterns using a deep convolutional neural network (CNN), with an architecture designed for the specific problem. In this study, we present an improved method for training the proposed network by transferring knowledge from the similar domain of general texture classification. Six publicly available texture databases are used to pretrain networks with the proposed architecture, which are then fine-tuned on the lung tissue data. The resulting CNNs are combined in an ensemble and their fused knowledge is compressed back to a network with the original architecture. The proposed approach resulted in an absolute increase of about 2 in the performance of the proposed CNN. The results demonstrate the potential of transfer learning in the field of medical image analysis, indicate the textural nature of the problem and show that the method used for training a network can be as important as designing its architecture. Matching images and sentences demands a fine understanding of both modalities. In this paper, we propose a new system to discriminatively embed the image and text to a shared visual-textual space. In this field, most existing works apply the ranking loss to pull the positive image text pairs close and push the negative pairs apart from each other. However, directly deploying the ranking loss is hard for network learning, since it starts from the two heterogeneous features to build inter-modal relationship. To address this problem, we propose the instance loss which explicitly considers the intra-modal data distribution. It is based on an unsupervised assumption that each image text group can be viewed as a class. So the network can learn the fine granularity from every image text group. The experiment shows that the instance loss offers better weight initialization for the ranking loss, so that more discriminative embeddings can be learned. Besides, existing works usually apply the off-the-shelf features, i.e., word2vec and fixed visual feature. So in a minor contribution, this paper constructs an end-to-end dual-path convolutional network to learn the image and text representations. End-to-end learning allows the system to directly learn from the data and fully utilize the supervision. On two generic retrieval datasets (Flickr30k and MSCOCO), experiments demonstrate that our method yields competitive accuracy compared to state-of-the-art methods. Moreover, in language based person retrieval, we improve the state of the art by a large margin. The code has been made publicly available. This paper addresses the task of aligning a database with a corresponding text. The goal is to link individual database entries with sentences that verbalize the same information. By providing explicit semantics-to-text links, these alignments can aid the training of natural language generation and information extraction systems. Beyond these pragmatic benefits, the alignment problem is appealing from a modeling perspective: the mappings between database entries and text sentences exhibit rich structural dependencies, unique to this task. Thus, the key challenge is to make use of as many global dependencies as possible without sacrificing tractability. To this end, we cast text-database alignment as a structured multilabel classification task where each sentence is labeled with a subset of matching database entries. In contrast to existing multilabel classifiers, our approach operates over arbitrary global features of inputs and proposed labels. We compare our model with a baseline classifier that makes locally optimal decisions. Our results show that the proposed model yields a 15 relative reduction in error, and compares favorably with human performance.